-- dump date 20250517_150143 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GeneID -- field 3 chrom_position -- field 4 chromosome -- field 5 codon_start -- field 6 contig -- field 7 description -- field 8 end_pos -- field 9 gene -- field 10 gene_id -- field 11 name -- field 12 organism -- field 13 product -- field 14 protein_id -- field 15 start_pos -- field 16 strand -- field 17 taxid -- field 18 type -- header -- id GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type KLLA0_A00110g 2896440 2788..3834 A 1 NC_006037.1 conserved hypothetical protein; uncharacterized protein 3834 2896440 KLLA0_A00110g Kluyveromyces lactis uncharacterized protein XP_451004.1 2788 D 28985 CDS KLLA0_A00132g 2896317 4628..6151 A 1 NC_006037.1 similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport; uncharacterized protein 6151 2896317 KLLA0_A00132g Kluyveromyces lactis uncharacterized protein XP_451005.1 4628 D 28985 CDS KLLA0_A00143g 9487514 complement(6838..7056) A 1 NC_006037.1 conserved hypothetical protein; uncharacterized protein 7056 9487514 KLLA0_A00143g Kluyveromyces lactis uncharacterized protein XP_002999344.1 6838 R 28985 CDS KLLA0_A00154g 2896494 8139..8579 A 1 NC_006037.1 conserved hypothetical protein; uncharacterized protein 8579 2896494 KLLA0_A00154g Kluyveromyces lactis uncharacterized protein XP_451006.2 8139 D 28985 CDS KLLA0_A00176g 2896752 complement(10102..11511) A 1 NC_006037.1 similar to uniprot|P24031 Saccharomyces cerevisiae YBR092C PHO3 Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin; uncharacterized protein 11511 2896752 KLLA0_A00176g Kluyveromyces lactis uncharacterized protein XP_451007.1 10102 R 28985 CDS KLLA0_A00198g 2896472 complement(14237..15211) A 1 NC_006037.1 highly similar to uniprot|P32318 Saccharomyces cerevisiae YGR144W THI4 Protein required for thiamine biosynthesis and for mitochondrial genome stability; thiamine thiazole synthase 15211 2896472 KLLA0_A00198g Kluyveromyces lactis thiamine thiazole synthase XP_451008.1 14237 R 28985 CDS KLLA0_A00220g 2896501 17582..18067 A 1 NC_006037.1 some similarities with uniprot|Q2S3S7 Salinibacter ruber SRU_1022 Mitochondrial benzodiazepine receptor/sensory transduction protein; uncharacterized protein 18067 2896501 KLLA0_A00220g Kluyveromyces lactis uncharacterized protein XP_451009.1 17582 D 28985 CDS KLLA0_A00242g 2896706 complement(18272..19105) A 1 NC_006037.1 similar to uniprot|P25613 Saccharomyces cerevisiae YCR010C ADY2 Accumulation of DYads member of the TC 9.B.33 YaaH family of putative transporters Protein involved in Accumulation of DYads or uniprot|P32907 Saccharomyces cerevisiae YNR002c; uncharacterized protein 19105 2896706 KLLA0_A00242g Kluyveromyces lactis uncharacterized protein XP_451010.1 18272 R 28985 CDS KLLA0_A00264g 2896599 20634..21338 A 1 NC_006037.1 highly similar to uniprot|P40582 Saccharomyces cerevisiae YIR038C GTT1 ER associated glutathione S-transferase capable of homodimerization expression induced during the diauxic shift and throughout stationary phase functional overlap with Gtt2p Grx1p and Grx2p; bifunctional glutathione transferase/peroxidase 21338 2896599 KLLA0_A00264g Kluyveromyces lactis bifunctional glutathione transferase/peroxidase XP_451011.1 20634 D 28985 CDS KLLA0_A00286g 2896597 complement(22024..25698) A 1 NC_006037.1 similar to uniprot|P47037 Saccharomyces cerevisiae YJL074C SMC3 Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; cohesin subunit SMC3 25698 2896597 KLLA0_A00286g Kluyveromyces lactis cohesin subunit SMC3 XP_451012.2 22024 R 28985 CDS KLLA0_A00352g 2896502 complement(26582..27238) A 1 NC_006037.1 similar to uniprot|P43544 Saccharomyces cerevisiae YFL060C SNO3 Protein of unknown function nearly identical to Sno2p expression is induced before the diauxic shift and also in the absence of thiamin and uniprot|P53823 Saccharomyces cerevisiae YNL334C SNO2 and uniprot|Q03144 Saccharomyces cerevisiae YMR095C SNO1; uncharacterized protein 27238 2896502 KLLA0_A00352g Kluyveromyces lactis uncharacterized protein XP_451013.1 26582 R 28985 CDS KLLA0_A00374g 2896469 28198..29091 A 1 NC_006037.1 highly similar to uniprot|P43545 Saccharomyces cerevisiae YFL059W SNZ3 Member of a stationary phase-induced gene family transcription of SNZ2 is induced prior to diauxic shift and also in the absence of thiamin in a Thi2p-dependent manner forms a coregulated gene pair with SNO3 and uniprot|P53824 Saccharomyces cerevisiae YNL333W SNZ2 and YMR096W uniprot|Q03148 Saccharomyces cerevisiae YMR096W SNZ1; uncharacterized protein 29091 2896469 KLLA0_A00374g Kluyveromyces lactis uncharacterized protein XP_451014.1 28198 D 28985 CDS KLLA0_A00396g 2896495 29717..32755 A 1 NC_006037.1 similar to uniprot|P40453 Saccharomyces cerevisiae YIL156W UBP7 Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; ubiquitin-specific protease UBP7 32755 2896495 KLLA0_A00396g Kluyveromyces lactis ubiquitin-specific protease UBP7 XP_451015.1 29717 D 28985 CDS KLLA0_A00418g 2896315 complement(33084..35012) A 1 NC_006037.1 similar to uniprot|P32191 Saccharomyces cerevisiae YIL155C GUT2 Mitochondrial glycerol-3-phosphate dehydrogenase expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p Rsf1p Hap2/3/4/5 complex dependent manner; glycerol-3-phosphate dehydrogenase 35012 2896315 KLLA0_A00418g Kluyveromyces lactis glycerol-3-phosphate dehydrogenase XP_451016.1 33084 R 28985 CDS KLLA0_A00440g 2896426 complement(37134..38201) A 1 NC_006037.1 similar to uniprot|Q753L8 Ashbya gossypii AFR294W AFR294Wp and weakly similar to YIL154C uniprot|P32351 Saccharomyces cerevisiae YIL154C IMP2' Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants contains a C-terminal leucine-rich repeat; uncharacterized protein 38201 2896426 KLLA0_A00440g Kluyveromyces lactis uncharacterized protein XP_451017.1 37134 R 28985 CDS KLLA0_A00462g 2896400 38766..39827 A 1 NC_006037.1 similar to uniprot|P40454 Saccharomyces cerevisiae YIL153W RRD1 Resistant to Rapamycin Deletion; peptidylprolyl isomerase RRD1 39827 2896400 KLLA0_A00462g Kluyveromyces lactis peptidylprolyl isomerase RRD1 XP_451018.1 38766 D 28985 CDS KLLA0_A00484g 2896341 complement(40330..41961) A 1 NC_006037.1 highly similar to uniprot|P10963 Saccharomyces cerevisiae YKR097W PCK1 Phosphoenolpyruvate carboxykinase key enzyme in gluconeogenesis catalyzes early reaction in carbohydrate biosynthesis glucose represses transcription and accelerates mRNA degradation regulated by Mcm1p and Cat8p located in the cytosol; phosphoenolpyruvate carboxykinase PCK1 41961 2896341 KLLA0_A00484g Kluyveromyces lactis phosphoenolpyruvate carboxykinase PCK1 XP_451019.1 40330 R 28985 CDS KLLA0_A00506g 2896473 43949..44488 A 1 NC_006037.1 no similarity; uncharacterized protein 44488 2896473 KLLA0_A00506g Kluyveromyces lactis uncharacterized protein XP_451020.1 43949 D 28985 CDS KLLA0_A00528g 2896526 complement(44587..48276) A 1 NC_006037.1 similar to uniprot|P36168 Saccharomyces cerevisiae YKR096W; uncharacterized protein 48276 2896526 KLLA0_A00528g Kluyveromyces lactis uncharacterized protein XP_451021.1 44587 R 28985 CDS KLLA0_A00539g 9487336 complement(join(49433..49661,49740..49774)) A 1 NC_006037.1 highly similar to uniprot|Q3E833 Saccharomyces cerevisiae YKR095W-A PCC1 Protein; chromatin DNA-binding EKC/KEOPS complex subunit PCC1 49774 9487336 KLLA0_A00539g Kluyveromyces lactis chromatin DNA-binding EKC/KEOPS complex subunit PCC1 XP_002999345.1 49433 R 28985 CDS KLLA0_A00550g 2896444 50099..51241 A 1 NC_006037.1 conserved hypothetical protein; uncharacterized protein 51241 2896444 KLLA0_A00550g Kluyveromyces lactis uncharacterized protein XP_451022.1 50099 D 28985 CDS KLLA0_A00572g 2896570 complement(join(51265..52910,52994..53081)) A 1 NC_006037.1 similar to uniprot|P32354 Saccharomyces cerevisiae YIL150C MCM10 Essential chromatin-associated protein involved in the initiation of DNA replication; uncharacterized protein 53081 2896570 KLLA0_A00572g Kluyveromyces lactis uncharacterized protein XP_451023.1 51265 R 28985 CDS KLLA0_A00594g 2896790 complement(53304..58550) A 1 NC_006037.1 similar to uniprot|Q02455 Saccharomyces cerevisiae YKR095W MLP1 Myosin-like protein associated with the nuclear envelope connects the nuclear pore complex with the nuclear interior involved in the Tel1p pathway that controls telomere length involved in the retention of unspliced mRNAs in the nucleus; uncharacterized protein 58550 2896790 KLLA0_A00594g Kluyveromyces lactis uncharacterized protein XP_451024.1 53304 R 28985 CDS KLLA0_A00616g 2896556 join(59180..59187,59727..60105) A 1 NC_006037.1 highly similar to uniprot|P04838 Saccharomyces cerevisiae YKR094C RPL40B Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; ubiquitin-60S ribosomal protein L40 fusion protein 60105 2896556 KLLA0_A00616g Kluyveromyces lactis ubiquitin-60S ribosomal protein L40 fusion protein XP_451025.2 59180 D 28985 CDS KLLA0_A00638g 2896600 complement(60378..63845) A 1 NC_006037.1 similar to uniprot|P39928 Saccharomyces cerevisiae YIL147C SLN1 Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators; histidine kinase 63845 2896600 KLLA0_A00638g Kluyveromyces lactis histidine kinase XP_451026.1 60378 R 28985 CDS KLLA0_A00660g 2896568 complement(64397..65971) A 1 NC_006037.1 weakly similar to uniprot|P40458 Saccharomyces cerevisiae YIL146C ECM37 Non-essential protein of unknown function; mitophagy protein ATG32 65971 2896568 KLLA0_A00660g Kluyveromyces lactis mitophagy protein ATG32 XP_451027.1 64397 R 28985 CDS KLLA0_A00682g 2896553 67685..69811 A 1 NC_006037.1 highly similar to uniprot|P46655 Saccharomyces cerevisiae YGL245W GUS1 Glutamyl-tRNA synthetase (GluRS) forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; glutamate--tRNA ligase GUS1 69811 2896553 KLLA0_A00682g Kluyveromyces lactis glutamate--tRNA ligase GUS1 XP_451028.1 67685 D 28985 CDS KLLA0_A00715g 2896602 complement(69861..71636) A 1 NC_006037.1 weakly similar to uniprot|P43620 Saccharomyces cerevisiae YFR048W RMD8 Cytosolic protein required for sporulation; uncharacterized protein 71636 2896602 KLLA0_A00715g Kluyveromyces lactis uncharacterized protein XP_451030.1 69861 R 28985 CDS KLLA0_A00737g 2896582 72233..73981 A 1 NC_006037.1 similar to uniprot|P53064 Saccharomyces cerevisiae YGL244W RTF1 Subunit of the RNA polymerase II-associated Paf1 complex directly or indirectly regulates DNA-binding properties of Spt15p (TATA box-binding protein) and relative activities of different TATA elements; uncharacterized protein 73981 2896582 KLLA0_A00737g Kluyveromyces lactis uncharacterized protein XP_451031.1 72233 D 28985 CDS KLLA0_A00759g 2896665 74187..75329 A 1 NC_006037.1 similar to uniprot|P53065 Saccharomyces cerevisiae YGL243W TAD1 tRNA-specific adenosine deaminase deaminates adenosine-37 to inosine in tRNA-Ala; tRNA-specific adenosine deaminase 75329 2896665 KLLA0_A00759g Kluyveromyces lactis tRNA-specific adenosine deaminase XP_451032.1 74187 D 28985 CDS KLLA0_A00781g 2896370 complement(75435..75950) A 1 NC_006037.1 similar to uniprot|P53066 Saccharomyces cerevisiae YGL242C Hypothetical ORF; uncharacterized protein 75950 2896370 KLLA0_A00781g Kluyveromyces lactis uncharacterized protein XP_451033.1 75435 R 28985 CDS KLLA0_A00803g 2896560 76350..79208 A 1 NC_006037.1 similar to uniprot|P53067 Saccharomyces cerevisiae YGL241W KAP114 Karyopherin, responsible for nuclear import of Spt15p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; uncharacterized protein 79208 2896560 KLLA0_A00803g Kluyveromyces lactis uncharacterized protein XP_451034.1 76350 D 28985 CDS KLLA0_A00825g 2896561 79588..80595 A 1 NC_006037.1 no similarity; uncharacterized protein 80595 2896561 KLLA0_A00825g Kluyveromyces lactis uncharacterized protein XP_451035.1 79588 D 28985 CDS KLLA0_A00847g 2896488 80886..81668 A 1 NC_006037.1 weakly similar to uniprot|P53068 Saccharomyces cerevisiae YGL240W DOC1 Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC) mediates the activity of the APC by contributing to substrate recognition involved in cyclin proteolysis; anaphase promoting complex subunit DOC1 81668 2896488 KLLA0_A00847g Kluyveromyces lactis anaphase promoting complex subunit DOC1 XP_451036.1 80886 D 28985 CDS KLLA0_A00869g 2896506 81975..84857 A 1 NC_006037.1 highly similar to uniprot|P33307 Saccharomyces cerevisiae YGL238W CSE1 Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p) homolog of metazoan CAS protein required for accurate chromosome segregation; importin-alpha export receptor 84857 2896506 KLLA0_A00869g Kluyveromyces lactis importin-alpha export receptor XP_451037.1 81975 D 28985 CDS KLLA0_A00891g 2896304 complement(85013..85915) A 1 NC_006037.1 uniprot|P53768 Kluyveromyces lactis KLLA0A00891g HAP2 Transcriptional activator HAP2; transcription activator HAP2 85915 2896304 KLLA0_A00891g Kluyveromyces lactis transcription activator HAP2 XP_451038.1 85013 R 28985 CDS KLLA0_A00913g 2896591 86295..87059 A 1 NC_006037.1 conserved hypothetical protein; uncharacterized protein 87059 2896591 KLLA0_A00913g Kluyveromyces lactis uncharacterized protein XP_451039.1 86295 D 28985 CDS KLLA0_A00935g 2896836 complement(87118..89178) A 1 NC_006037.1 similar to uniprot|P53070 Saccharomyces cerevisiae YGL236C MTO1 Mitochondrial protein required for respiration in paromomycin-resistant 15S rRNA mutants forms a heterodimer complex with Mss1p that plays a role in optimizing mitochondrial protein synthesis; tRNA modification protein MTO1 89178 2896836 KLLA0_A00935g Kluyveromyces lactis tRNA modification protein MTO1 XP_451040.1 87118 R 28985 CDS KLLA0_A00957g 2896609 89999..92377 A 1 NC_006037.1 uniprot|Q9HG45 Kluyveromyces lactis Purine biosynthetic pathway protein ADE5,7; bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase 92377 2896609 KLLA0_A00957g Kluyveromyces lactis bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase XP_451041.1 89999 D 28985 CDS KLLA0_A00979g 2896314 complement(92561..93592) A 1 NC_006037.1 some similarities with uniprot|P38152 Saccharomyces cerevisiae YBR291C CTP1 Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family; uncharacterized protein 93592 2896314 KLLA0_A00979g Kluyveromyces lactis uncharacterized protein XP_451042.1 92561 R 28985 CDS KLLA0_A01001g 2896515 94392..95993 A 1 NC_006037.1 highly similar to uniprot|P43616 Saccharomyces cerevisiae YFR044C; metallodipeptidase 95993 2896515 KLLA0_A01001g Kluyveromyces lactis metallodipeptidase XP_451043.1 94392 D 28985 CDS KLLA0_A01023g 2896305 96383..98968 A 1 NC_006037.1 similar to uniprot|P22224 Saccharomyces cerevisiae YGL233W SEC15 Essential 113kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) which mediates polarized targeting of vesicles to active sites of exocytosis Sec15p associates with Sec4p and vesicles; Rab GTPase-binding exocyst subunit SEC15 98968 2896305 KLLA0_A01023g Kluyveromyces lactis Rab GTPase-binding exocyst subunit SEC15 XP_451044.1 96383 D 28985 CDS KLLA0_A01045g 2896661 99292..100221 A 1 NC_006037.1 similar to uniprot|P53072 Saccharomyces cerevisiae YGL232W TAN1 Putative tRNA acetyltransferase RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; uncharacterized protein 100221 2896661 KLLA0_A01045g Kluyveromyces lactis uncharacterized protein XP_451045.1 99292 D 28985 CDS KLLA0_A01067g 2896413 complement(100259..100867) A 1 NC_006037.1 similar to uniprot|P53073 Saccharomyces cerevisiae YGL231C; chaperone EMC4 100867 2896413 KLLA0_A01067g Kluyveromyces lactis chaperone EMC4 XP_451046.1 100259 R 28985 CDS KLLA0_A01089g 2896605 102036..102737 A 1 NC_006037.1 weakly similar to uniprot|P43615 Saccharomyces cerevisiae YFR043C; uncharacterized protein 102737 2896605 KLLA0_A01089g Kluyveromyces lactis uncharacterized protein XP_451047.1 102036 D 28985 CDS KLLA0_A01111g 2896543 complement(102802..103431) A 1 NC_006037.1 similar to uniprot|P43614 Saccharomyces cerevisiae YFR042W Protein required for cell viability; uncharacterized protein 103431 2896543 KLLA0_A01111g Kluyveromyces lactis uncharacterized protein XP_451048.1 102802 R 28985 CDS KLLA0_A01133g 2896646 103746..104579 A 1 NC_006037.1 similar to uniprot|P43613 Saccharomyces cerevisiae YFR041C ERJ5 Endoplasmic reticulum protein that may function as a cochaperone as suggested by the presence of a DnaJ-like domain; uncharacterized protein 104579 2896646 KLLA0_A01133g Kluyveromyces lactis uncharacterized protein XP_451049.1 103746 D 28985 CDS KLLA0_A01155g 2896619 complement(104687..107668) A 1 NC_006037.1 similar to uniprot|P43612 Saccharomyces cerevisiae YFR040W; uncharacterized protein 107668 2896619 KLLA0_A01155g Kluyveromyces lactis uncharacterized protein XP_451050.1 104687 R 28985 CDS KLLA0_A01177g 2896462 108738..110648 A 1 NC_006037.1 weakly similar to uniprot|P53075 Saccharomyces cerevisiae YGL228W SHE10 Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function overexpression causes growth arrest; uncharacterized protein 110648 2896462 KLLA0_A01177g Kluyveromyces lactis uncharacterized protein XP_451051.1 108738 D 28985 CDS KLLA0_A01199g 2896612 111159..112508 A 1 NC_006037.1 highly similar to uniprot|P39954 Saccharomyces cerevisiae YER043C SAH1 S-adenosyl-L-homocysteine hydrolase catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor; adenosylhomocysteinase 112508 2896612 KLLA0_A01199g Kluyveromyces lactis adenosylhomocysteinase XP_451052.1 111159 D 28985 CDS KLLA0_A01221g 2896654 113308..115926 A 1 NC_006037.1 weakly similar to uniprot|P53076 Saccharomyces cerevisiae YGL227W; glucose-induced degradation complex subunit VID30 115926 2896654 KLLA0_A01221g Kluyveromyces lactis glucose-induced degradation complex subunit VID30 XP_451053.1 113308 D 28985 CDS KLLA0_A01287g 2896451 complement(join(115966..116235,116320..116340)) A 1 NC_006037.1 similar to uniprot|Q92316 Saccharomyces cerevisiae YGL226C-A OST5 Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; dolichyl-diphosphooligosaccharide--protein glycotransferase subunit 116340 2896451 KLLA0_A01287g Kluyveromyces lactis dolichyl-diphosphooligosaccharide--protein glycotransferase subunit XP_451054.2 115966 R 28985 CDS KLLA0_A01297g 2896603 116612..117037 A 1 NC_006037.1 similar to uniprot|P53077 Saccharomyces cerevisiae YGL226W; uncharacterized protein 117037 2896603 KLLA0_A01297g Kluyveromyces lactis uncharacterized protein XP_451055.1 116612 D 28985 CDS KLLA0_A01309g 2896795 complement(117215..117769) A 1 NC_006037.1 highly similar to uniprot|P40029 Saccharomyces cerevisiae YER042W MXR1 Peptide methionine sulfoxide reductase reverses the oxidation of methionine residues involved in oxidative damage repair providing resistance to oxidative stress and regulation of lifespan; peptide-methionine-S-sulfoxide reductase 117769 2896795 KLLA0_A01309g Kluyveromyces lactis peptide-methionine-S-sulfoxide reductase XP_451056.1 117215 R 28985 CDS KLLA0_A01320g 2896639 complement(118369..120123) A 1 NC_006037.1 weakly similar to uniprot|P40028 Saccharomyces cerevisiae YER041W YEN1 Protein of unknown function has similarity to endonuclease Rth1p potentially phosphorylated by Cdc28p; crossover junction endodeoxyribonuclease 120123 2896639 KLLA0_A01320g Kluyveromyces lactis crossover junction endodeoxyribonuclease XP_451057.1 118369 R 28985 CDS KLLA0_A01342g 2896630 complement(120385..122730) A 1 NC_006037.1 some similarities with uniprot|P18494 Saccharomyces cerevisiae YER040W GLN3 Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR) localization and activity regulated by quality of nitrogen source; nitrogen-responsive transcriptional regulator GLN3 122730 2896630 KLLA0_A01342g Kluyveromyces lactis nitrogen-responsive transcriptional regulator GLN3 XP_451058.1 120385 R 28985 CDS KLLA0_A01364g 2896624 124161..125153 A 1 NC_006037.1 similar to uniprot|P40107 Saccharomyces cerevisiae YGL225W VRG4 May regulate Golgi function and glycosylation in Golgi Golgi GDP-mannose transporter; GDP-mannose transporter 125153 2896624 KLLA0_A01364g Kluyveromyces lactis GDP-mannose transporter XP_451059.1 124161 D 28985 CDS KLLA0_A01386g 2896455 125585..126721 A 1 NC_006037.1 weakly similar to uniprot|P40026 Saccharomyces cerevisiae YER038C KRE29 Essential protein of unknown function heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance; Smc5-Smc6 complex subunit KRE29 126721 2896455 KLLA0_A01386g Kluyveromyces lactis Smc5-Smc6 complex subunit KRE29 XP_451060.1 125585 D 28985 CDS KLLA0_A01408g 2896637 complement(126900..127760) A 1 NC_006037.1 similar to uniprot|P53078 Saccharomyces cerevisiae YGL224C SDT1 Pyrimidine nucleotidase overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II as well as resistance to other pyrimidine derivatives and to uniprot|P40025 Saccharomyces cerevisiae YER037W PHM8; uncharacterized protein 127760 2896637 KLLA0_A01408g Kluyveromyces lactis uncharacterized protein XP_451061.1 126900 R 28985 CDS KLLA0_A01430g 2896622 complement(128139..129287) A 1 NC_006037.1 weakly similar to uniprot|P53079 Saccharomyces cerevisiae YGL223C COG1 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; uncharacterized protein 129287 2896622 KLLA0_A01430g Kluyveromyces lactis uncharacterized protein XP_451062.1 128139 R 28985 CDS KLLA0_A01452g 2896453 130078..131901 A 1 NC_006037.1 highly similar to uniprot|P40024 Saccharomyces cerevisiae YER036C; ATP-binding cassette family ATPase ARB1 131901 2896453 KLLA0_A01452g Kluyveromyces lactis ATP-binding cassette family ATPase ARB1 XP_451063.1 130078 D 28985 CDS KLLA0_A01474g 2896657 complement(132423..133565) A 1 NC_006037.1 some similarities with uniprot|P53080 Saccharomyces cerevisiae YGL222C EDC1 RNA-binding protein activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p; uncharacterized protein 133565 2896657 KLLA0_A01474g Kluyveromyces lactis uncharacterized protein XP_451064.1 132423 R 28985 CDS KLLA0_A01496g 2896652 complement(134214..134804) A 1 NC_006037.1 some similarities with uniprot|P40022 Saccharomyces cerevisiae YER034W; uncharacterized protein 134804 2896652 KLLA0_A01496g Kluyveromyces lactis uncharacterized protein XP_451065.1 134214 R 28985 CDS KLLA0_A01518g 2896503 complement(135063..135920) A 1 NC_006037.1 similar to uniprot|P53081 Saccharomyces cerevisiae YGL221C; uncharacterized protein 135920 2896503 KLLA0_A01518g Kluyveromyces lactis uncharacterized protein XP_451066.1 135063 R 28985 CDS KLLA0_A01551g 2896576 136238..136495 A 1 NC_006037.1 similar to uniprot|P53082 Saccharomyces cerevisiae YGL220W; uncharacterized protein 136495 2896576 KLLA0_A01551g Kluyveromyces lactis uncharacterized protein XP_451067.1 136238 D 28985 CDS KLLA0_A01573g 2896711 complement(136823..138445) A 1 NC_006037.1 similar to uniprot|P53083 Saccharomyces cerevisiae YGL219C MDM34 Mitochondrial outer membrane protein colocalizes with mtDNA nucleids required for mitochondria shape; ERMES complex subunit MDM34 138445 2896711 KLLA0_A01573g Kluyveromyces lactis ERMES complex subunit MDM34 XP_451068.1 136823 R 28985 CDS KLLA0_A01606g 2896695 139355..141664 A 1 NC_006037.1 similar to uniprot|P53086 Saccharomyces cerevisiae YGL216W KIP3 Kinesin-related motor protein involved in mitotic spindle positioning; tubulin-dependent ATPase KIP3 141664 2896695 KLLA0_A01606g Kluyveromyces lactis tubulin-dependent ATPase KIP3 XP_451070.1 139355 D 28985 CDS KLLA0_A01628g 2896587 143922..145160 A 1 NC_006037.1 weakly similar to uniprot|P35190 Saccharomyces cerevisiae YGL215W CLG1 cyclin-like protein that interacts with Pho85p in affinity chromatography cyclin-like protein that interacts with Pho85; uncharacterized protein 145160 2896587 KLLA0_A01628g Kluyveromyces lactis uncharacterized protein XP_451071.1 143922 D 28985 CDS KLLA0_A01650g 2896410 complement(146030..147235) A 1 NC_006037.1 similar to uniprot|Q02793 Saccharomyces cerevisiae YGL213C SKI8 essential for protection against viral cytopathology dispensable for mitotic but required for meiotic recombination and spore viability antiviral protein mRNA is induced early in meiosis; SKI complex subunit WD repeat protein SKI8 147235 2896410 KLLA0_A01650g Kluyveromyces lactis SKI complex subunit WD repeat protein SKI8 XP_451072.1 146030 R 28985 CDS KLLA0_A01672g 2896577 147876..148916 A 1 NC_006037.1 similar to uniprot|Q755T0 Ashbya gossypii AER438C AER438Cp and weakly similar to YGL212W uniprot|P32912 Saccharomyces cerevisiae YGL212W VAM7 Regulator of vacuolar morphogenesis hydrophilic protein heptad repeat motif; uncharacterized protein 148916 2896577 KLLA0_A01672g Kluyveromyces lactis uncharacterized protein XP_451073.1 147876 D 28985 CDS KLLA0_A01694g 2896653 complement(149587..151293) A 1 NC_006037.1 weakly similar to uniprot|P25346 YCR098C Saccharomyces cerevisiae GIT1 Plasma membrane permease, mediates uptake of the phosphatidylinositol metabolite glycerophosphoinositol; uncharacterized protein 151293 2896653 KLLA0_A01694g Kluyveromyces lactis uncharacterized protein XP_451074.1 149587 R 28985 CDS KLLA0_A01738g 2896594 complement(152383..153498) A 1 NC_006037.1 highly similar to uniprot|P25087 Saccharomyces cerevisiae YML008C ERG6 Delta(24)-sterol C-methyltransferase; sterol 24-C-methyltransferase 153498 2896594 KLLA0_A01738g Kluyveromyces lactis sterol 24-C-methyltransferase XP_451076.1 152383 R 28985 CDS KLLA0_A01760g 2896569 154859..156610 A 1 NC_006037.1 uniprot|P56095 Kluyveromyces lactis KLLA0A01760g YAP1 AP- 1-like transcription factor; uncharacterized protein 156610 2896569 KLLA0_A01760g Kluyveromyces lactis uncharacterized protein XP_451077.1 154859 D 28985 CDS KLLA0_A01782g 2896395 complement(157216..158802) A 1 NC_006037.1 some similarities with uniprot|Q04233 Saccharomyces cerevisiae YML006C GIS4 CAAX box containing protein of unknown function proposed to be involved in the RAS/cAMP signaling pathway; uncharacterized protein 158802 2896395 KLLA0_A01782g Kluyveromyces lactis uncharacterized protein XP_451078.1 157216 R 28985 CDS KLLA0_A01804g 2896589 complement(159689..162526) A 1 NC_006037.1 similar to uniprot|Q04052 Saccharomyces cerevisiae YDR421W ARO80 Zinc finger transcriptional activator of the Zn2Cys6 family activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids; uncharacterized protein 162526 2896589 KLLA0_A01804g Kluyveromyces lactis uncharacterized protein XP_451079.1 159689 R 28985 CDS KLLA0_A01826g 2896555 complement(163010..167404) A 1 NC_006037.1 some similarities with uniprot|P41809 Saccharomyces cerevisiae YDR420W HKR1 Serine/threonine rich cell surface protein that contains an EF hand motif involved in the regulation of cell wall beta-1 3 glucan synthesis and bud site selection overexpression confers resistance to Hansenula mrakii killer toxin HM-1; uncharacterized protein 167404 2896555 KLLA0_A01826g Kluyveromyces lactis uncharacterized protein XP_451080.1 163010 R 28985 CDS KLLA0_A01848g 2896756 complement(167886..169823) A 1 NC_006037.1 similar to uniprot|Q04049 YDR419W Saccharomyces cerevisiae RAD30 DNA polymerase eta involved in the predominantly error-free bypass replication of DNA lesions; DNA-directed DNA polymerase eta 169823 2896756 KLLA0_A01848g Kluyveromyces lactis DNA-directed DNA polymerase eta XP_451081.1 167886 R 28985 CDS KLLA0_A01870g 2896366 complement(170104..170985) A 1 NC_006037.1 conserved hypothetical protein; uncharacterized protein 170985 2896366 KLLA0_A01870g Kluyveromyces lactis uncharacterized protein XP_451082.1 170104 R 28985 CDS KLLA0_A01903g 2896418 complement(172232..172729) A 1 NC_006037.1 highly similar to uniprot|P17079 YEL054C Saccharomyces cerevisiae RPL12A or uniprot|P17079 Saccharomyces cerevisiae YDR418w RPL12A Protein component of the large (60S) ribosomal subunit; 60S ribosomal protein uL11 172729 2896418 KLLA0_A01903g Kluyveromyces lactis 60S ribosomal protein uL11 XP_451084.1 172232 R 28985 CDS KLLA0_A01925g 2896466 complement(173617..175977) A 1 NC_006037.1 similar to uniprot|Q02197 Saccharomyces cerevisiae YEL053C MAK10 Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; uncharacterized protein 175977 2896466 KLLA0_A01925g Kluyveromyces lactis uncharacterized protein XP_451085.1 173617 R 28985 CDS KLLA0_A01947g 2896478 176815..178338 A 1 NC_006037.1 similar to uniprot|P32317 YEL052W Saccharomyces cerevisiae AFG1 Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family localized to mitochondria; uncharacterized protein 178338 2896478 KLLA0_A01947g Kluyveromyces lactis uncharacterized protein XP_451086.1 176815 D 28985 CDS KLLA0_A01969g 2896491 complement(178458..180854) A 1 NC_006037.1 similar to uniprot|Q04048 Saccharomyces cerevisiae YDR416w SYF1 synthetic lethal with CDC40; mRNA splicing protein SYF1 180854 2896491 KLLA0_A01969g Kluyveromyces lactis mRNA splicing protein SYF1 XP_451087.1 178458 R 28985 CDS KLLA0_A01991g 2896714 181274..182104 A 1 NC_006037.1 highly similar to uniprot|P32610 YEL051W Saccharomyces cerevisiae VMA8 vacuolar ATPase V1 domain subunit D; H(+)-transporting V1 sector ATPase subunit D 182104 2896714 KLLA0_A01991g Kluyveromyces lactis H(+)-transporting V1 sector ATPase subunit D XP_451088.1 181274 D 28985 CDS KLLA0_A02013g 2896471 182326..183447 A 1 NC_006037.1 similar to uniprot|Q04033 Saccharomyces cerevisiae YDR415C; uncharacterized protein 183447 2896471 KLLA0_A02013g Kluyveromyces lactis uncharacterized protein XP_451089.1 182326 D 28985 CDS KLLA0_A02035g 2896496 complement(183620..184825) A 1 NC_006037.1 similar to uniprot|P32611 YEL050C Saccharomyces cerevisiae RML2 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein uL2m 184825 2896496 KLLA0_A02035g Kluyveromyces lactis mitochondrial 54S ribosomal protein uL2m XP_451090.1 183620 R 28985 CDS KLLA0_A02057g 2896854 186220..187374 A 1 NC_006037.1 uniprot|P41771 Kluyveromyces lactis KLLA0A02057g ERD1 Protein ERD1; uncharacterized protein 187374 2896854 KLLA0_A02057g Kluyveromyces lactis uncharacterized protein XP_451091.1 186220 D 28985 CDS KLLA0_A02079g 2896558 complement(187421..188152) A 1 NC_006037.1 similar to uniprot|Q04031 YDR412W Saccharomyces cerevisiae RRP17 Protein required for cell viability; uncharacterized protein 188152 2896558 KLLA0_A02079g Kluyveromyces lactis uncharacterized protein XP_451092.1 187421 R 28985 CDS KLLA0_A02101g 2896642 188671..189519 A 1 NC_006037.1 similar to uniprot|Q7LIJ5 Saccharomyces cerevisiae YDR411C DFM1; uncharacterized protein 189519 2896642 KLLA0_A02101g Kluyveromyces lactis uncharacterized protein XP_451093.1 188671 D 28985 CDS KLLA0_A02123g 2896578 190132..192165 A 1 NC_006037.1 similar to uniprot|P32796 YML042W Saccharomyces cerevisiae CAT2 Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes; carnitine O-acetyltransferase CAT2 192165 2896578 KLLA0_A02123g Kluyveromyces lactis carnitine O-acetyltransferase CAT2 XP_451094.1 190132 D 28985 CDS KLLA0_A02145g 2896620 192493..193242 A 1 NC_006037.1 similar to uniprot|Q03433 Saccharomyces cerevisiae YML041C VPS71 Protein of unknown function component of the Swr1p complex that incorporates Htz1p into chromatin required for vacuolar protein sorting; uncharacterized protein 193242 2896620 KLLA0_A02145g Kluyveromyces lactis uncharacterized protein XP_451095.1 192493 D 28985 CDS KLLA0_A02167g 2896574 193623..194369 A 1 NC_006037.1 similar to uniprot|P32584 Saccharomyces cerevisiae YDR410C STE14 Farnesyl cysteine-carboxyl methyltransferase mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum localizes to the ER membrane; protein-S-isoprenylcysteine carboxyl O-methyltransferase 194369 2896574 KLLA0_A02167g Kluyveromyces lactis protein-S-isoprenylcysteine carboxyl O-methyltransferase XP_451096.1 193623 D 28985 CDS KLLA0_A02189g 2896632 complement(194500..196848) A 1 NC_006037.1 some similarities with uniprot|Q04195 YDR409W Saccharomyces cerevisiae SIZ1 SUMO ligase that promotes the attachment of sumo (Smt3p small ubiquitin-related modifier) to proteins; uncharacterized protein 196848 2896632 KLLA0_A02189g Kluyveromyces lactis uncharacterized protein XP_451097.1 194500 R 28985 CDS KLLA0_A02211g 2896631 197863..198510 A 1 NC_006037.1 similar to uniprot|P04161 YDR408C Saccharomyces cerevisiae ADE8 Phosphoribosyl-glycinamide transformylase; phosphoribosylglycinamide formyltransferase 198510 2896631 KLLA0_A02211g Kluyveromyces lactis phosphoribosylglycinamide formyltransferase XP_451098.1 197863 D 28985 CDS KLLA0_A02233g 2896710 complement(198766..199554) A 1 NC_006037.1 highly similar to uniprot|P25043 YOR157C Saccharomyces cerevisiae PUP1 Endopeptidase with trypsin-like activity that cleaves after basic residues; proteasome core particle subunit beta 2 199554 2896710 KLLA0_A02233g Kluyveromyces lactis proteasome core particle subunit beta 2 XP_451099.1 198766 R 28985 CDS KLLA0_A02255g 2896610 199863..203495 A 1 NC_006037.1 similar to uniprot|Q04183 YDR407C Saccharomyces cerevisiae TRS120 Component of the targeting complex (TRAPP) involved in ER to Golgi membrane traffic; uncharacterized protein 203495 2896610 KLLA0_A02255g Kluyveromyces lactis uncharacterized protein XP_451100.1 199863 D 28985 CDS KLLA0_A02277g 2896687 203818..204732 A 1 NC_006037.1 similar to uniprot|P17558 Saccharomyces cerevisiae YOR158W PET123 Mitochondrial ribosomal protein of the small subunit PET123 exhibits genetic interactions with PET122 which encodes a COX3 mRNA-specific translational activator; mitochondrial 37S ribosomal protein PET123 204732 2896687 KLLA0_A02277g Kluyveromyces lactis mitochondrial 37S ribosomal protein PET123 XP_451101.1 203818 D 28985 CDS KLLA0_A02299g 2896689 complement(205013..205294) A 1 NC_006037.1 similar to uniprot|Q12330 YOR159C Saccharomyces cerevisiae SME1 Required for pre-mRNA splicing, cap modification and U1 U2 U4 and U5 snRNA stability; mRNA splicing protein SME1 205294 2896689 KLLA0_A02299g Kluyveromyces lactis mRNA splicing protein SME1 XP_451102.1 205013 R 28985 CDS KLLA0_A02321g 2896817 205567..208452 A 1 NC_006037.1 similar to uniprot|Q99189 Saccharomyces cerevisiae YOR160W MTR10 Nuclear import receptor mediates the nuclear localization of proteins involved in mRNA-nucleus export; uncharacterized protein 208452 2896817 KLLA0_A02321g Kluyveromyces lactis uncharacterized protein XP_451103.1 205567 D 28985 CDS KLLA0_A02343g 2896692 complement(208673..210334) A 1 NC_006037.1 similar to uniprot|Q12412 YOR161C Saccharomyces cerevisiae PNS1; uncharacterized protein 210334 2896692 KLLA0_A02343g Kluyveromyces lactis uncharacterized protein XP_451104.1 208673 R 28985 CDS KLLA0_A02365g 2896792 211300..212568 A 1 NC_006037.1 similar to uniprot|Q99312 YOR155C Saccharomyces cerevisiae ISN1 Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase; IMP 5'-nucleotidase 212568 2896792 KLLA0_A02365g Kluyveromyces lactis IMP 5'-nucleotidase XP_451105.1 211300 D 28985 CDS KLLA0_A02387g 2896789 213276..213779 A 1 NC_006037.1 no similarity; uncharacterized protein 213779 2896789 KLLA0_A02387g Kluyveromyces lactis uncharacterized protein XP_451106.1 213276 D 28985 CDS KLLA0_A02431g 2896794 complement(214580..215095) A 1 NC_006037.1 weakly similar to uniprot|Q2ZX20 Shewanella putrefaciens CN-32 Sputcn32DRAFT_3504 Hypothetical protein; uncharacterized protein 215095 2896794 KLLA0_A02431g Kluyveromyces lactis uncharacterized protein XP_451107.1 214580 R 28985 CDS KLLA0_A02453g 2896851 complement(215305..216177) A 1 NC_006037.1 similar to uniprot|P49954 Saccharomyces cerevisiae YLR351C; uncharacterized protein 216177 2896851 KLLA0_A02453g Kluyveromyces lactis uncharacterized protein XP_451108.1 215305 R 28985 CDS KLLA0_A02475g 2896688 complement(216566..217687) A 1 NC_006037.1 similar to uniprot|Q9HGY3 Candida boidinii DAO1 D-amino acid oxidase; uncharacterized protein 217687 2896688 KLLA0_A02475g Kluyveromyces lactis uncharacterized protein XP_451109.1 216566 R 28985 CDS KLLA0_A02497g 2896550 218592..219680 A 1 NC_006037.1 highly similar to uniprot|P14681 Saccharomyces cerevisiae YGR040W KSS1 Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; mitogen-activated serine/threonine-protein kinase KSS1 219680 2896550 KLLA0_A02497g Kluyveromyces lactis mitogen-activated serine/threonine-protein kinase KSS1 XP_451110.1 218592 D 28985 CDS KLLA0_A02519g 2896348 220146..222500 A 1 NC_006037.1 similar to uniprot|Q06479 Saccharomyces cerevisiae YLR352W; uncharacterized protein 222500 2896348 KLLA0_A02519g Kluyveromyces lactis uncharacterized protein XP_451111.1 220146 D 28985 CDS KLLA0_A02541g 2896539 223318..224913 A 1 NC_006037.1 some similarities with uniprot|P41698 Saccharomyces cerevisiae YLR353W BUD8 Protein involved in bud-site selection diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern and bud at the proximal pole; uncharacterized protein 224913 2896539 KLLA0_A02541g Kluyveromyces lactis uncharacterized protein XP_451112.1 223318 D 28985 CDS KLLA0_A02563g 2896608 225343..226095 A 1 NC_006037.1 similar to uniprot|Q75CW0 Ashbya gossypii ACL194C ACL194Cp and some similarites with YGR042W uniprot|P53227 Saccharomyces cerevisiae YGR042W; uncharacterized protein 226095 2896608 KLLA0_A02563g Kluyveromyces lactis uncharacterized protein XP_451113.1 225343 D 28985 CDS KLLA0_A02585g 2896358 complement(226562..227674) A 1 NC_006037.1 conserved hypothetical protein; uncharacterized protein 227674 2896358 KLLA0_A02585g Kluyveromyces lactis uncharacterized protein XP_451114.1 226562 R 28985 CDS KLLA0_A02607g 2896669 complement(231111..232115) A 1 NC_006037.1 highly similar to uniprot|P15019 Saccharomyces cerevisiae YLR354C TAL1 Transaldolase enzyme in the pentose phosphate pathway; uncharacterized protein 232115 2896669 KLLA0_A02607g Kluyveromyces lactis uncharacterized protein XP_451115.1 231111 R 28985 CDS KLLA0_A02629g 2896598 complement(233822..235501) A 1 NC_006037.1 some similarities with uniprot|P32338 Saccharomyces cerevisiae YGR044C RME1 mediates cell type control of sporulation negatively regulates IME1 and sporulation zinc finger protein negative regulator of meiosis directly repressed by a1-a2 regulator; uncharacterized protein 235501 2896598 KLLA0_A02629g Kluyveromyces lactis uncharacterized protein XP_451116.1 233822 R 28985 CDS KLLA0_A02651g 2896538 complement(238735..239409) A 1 NC_006037.1 similar to uniprot|P34227 Saccharomyces cerevisiae YBL064C PRX1 Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; uncharacterized protein 239409 2896538 KLLA0_A02651g Kluyveromyces lactis uncharacterized protein XP_451117.1 238735 R 28985 CDS KLLA0_A02673g 2896586 complement(240153..241346) A 1 NC_006037.1 highly similar to uniprot|P06168 Saccharomyces cerevisiae YLR355C ILV5 Acetohydroxyacid reductoisomerase mitochondrial protein involved in branched-chain amino acid biosynthesis also required for maintenance of wild- type mitochondrial DNA; ketol-acid reductoisomerase 241346 2896586 KLLA0_A02673g Kluyveromyces lactis ketol-acid reductoisomerase XP_451118.1 240153 R 28985 CDS KLLA0_A02695g 2896540 242521..243228 A 1 NC_006037.1 weakly similar to uniprot|Q06485 Saccharomyces cerevisiae YLR356W; uncharacterized protein 243228 2896540 KLLA0_A02695g Kluyveromyces lactis uncharacterized protein XP_451119.1 242521 D 28985 CDS KLLA0_A02717g 2896797 245082..246380 A 1 NC_006037.1 weakly similar to uniprot|P53233 Saccharomyces cerevisiae YGR052W FMP48 The authentic non-tagged protein was localized to the mitochondria; protein kinase FMP48 246380 2896797 KLLA0_A02717g Kluyveromyces lactis protein kinase FMP48 XP_451120.1 245082 D 28985 CDS KLLA0_A02739g 2896544 complement(246644..247255) A 1 NC_006037.1 some similarities with uniprot|Q45U33 Saccharomyces cerevisiae YGR053c; uncharacterized protein 247255 2896544 KLLA0_A02739g Kluyveromyces lactis uncharacterized protein XP_451121.1 246644 R 28985 CDS KLLA0_A02761g 2896306 247871..249628 A 1 NC_006037.1 similar to uniprot|P53235 Saccharomyces cerevisiae YGR054W yeast homolog of mammalian eIF2A; uncharacterized protein 249628 2896306 KLLA0_A02761g Kluyveromyces lactis uncharacterized protein XP_451122.1 247871 D 28985 CDS KLLA0_A02827g 2896542 250872..252191 A 1 NC_006037.1 highly similar to uniprot|P38755 Saccharomyces cerevisiae YHR001W OSH7 Member of an oxysterol-binding protein family with seven members in S. cerevisiae family members have overlapping redundant functions in sterol metabolism and collectively perform a function essential for viability; oxysterol-binding protein OSH6 252191 2896542 KLLA0_A02827g Kluyveromyces lactis oxysterol-binding protein OSH6 XP_451123.1 250872 D 28985 CDS KLLA0_A02849g 2896347 complement(252275..253204) A 1 NC_006037.1 weakly similar to uniprot|Q02202 Saccharomyces cerevisiae YKR004C ECM9 Non-essential protein of unknown function; uncharacterized protein 253204 2896347 KLLA0_A02849g Kluyveromyces lactis uncharacterized protein XP_451124.1 252275 R 28985 CDS KLLA0_A02871g 2896535 complement(253619..255511) A 1 NC_006037.1 conserved hypothetical protein; uncharacterized protein 255511 2896535 KLLA0_A02871g Kluyveromyces lactis uncharacterized protein XP_451125.1 253619 R 28985 CDS KLLA0_A02893g 2896343 256320..258233 A 1 NC_006037.1 conserved hypothetical protein; uncharacterized protein 258233 2896343 KLLA0_A02893g Kluyveromyces lactis uncharacterized protein XP_451126.1 256320 D 28985 CDS KLLA0_A02915g 2896349 complement(258504..259265) A 1 NC_006037.1 similar to uniprot|Q758P2 Ashbya gossypii AEL289W AEL289Wp and weakly similar to YKR006C uniprot|Q02204 Saccharomyces cerevisiae YKR006C MRPL13 Mitochondrial ribosomal protein of the large subunit not essential for mitochondrial translation; uncharacterized protein 259265 2896349 KLLA0_A02915g Kluyveromyces lactis uncharacterized protein XP_451127.1 258504 R 28985 CDS KLLA0_A02937g 2896530 259865..260296 A 1 NC_006037.1 some similarities with uniprot|Q02205 Saccharomyces cerevisiae YKR007W MEH1; uncharacterized protein 260296 2896530 KLLA0_A02937g Kluyveromyces lactis uncharacterized protein XP_451128.1 259865 D 28985 CDS KLLA0_A02959g 2896532 260627..262306 A 1 NC_006037.1 similar to uniprot|Q02206 Saccharomyces cerevisiae YKR008W RSC4 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex found in close proximity to nucleosomal DNA displaced from the surface of nucleosomal DNA after chromatin remodeling; uncharacterized protein 262306 2896532 KLLA0_A02959g Kluyveromyces lactis uncharacterized protein XP_451129.1 260627 D 28985 CDS KLLA0_A02981g 2896310 complement(262440..264356) A 1 NC_006037.1 weakly similar to uniprot|Q12188 Saccharomyces cerevisiae YPR007C REC8 Meiosis-specific component of sister chromatid cohesion complex maintains cohesion between sister chromatids during meiosis I maintains cohesion between centromeres of sister chromatids until meiosis II homolog of S. pombe Rec8p; uncharacterized protein 264356 2896310 KLLA0_A02981g Kluyveromyces lactis uncharacterized protein XP_451130.1 262440 R 28985 CDS KLLA0_A03003g 2896524 264785..265393 A 1 NC_006037.1 weakly similar to uniprot|P43592 Saccharomyces cerevisiae YFR008W FAR7 Protein involved in G1 cell cycle arrest in response to pheromone in a pathway different from the Far1p-dependent pathway interacts with Far3p Far8p Far9p Far10p and Far11p; uncharacterized protein 265393 2896524 KLLA0_A03003g Kluyveromyces lactis uncharacterized protein XP_451131.1 264785 D 28985 CDS KLLA0_A03025g 2896356 266917..268077 A 1 NC_006037.1 similar to uniprot|P40088 Saccharomyces cerevisiae YER145C FTR1 High affinity iron permease involved in the transport of iron across the plasma membrane forms complex with Fet3p expression is regulated by iron; high-affinity iron permease FTR1 268077 2896356 KLLA0_A03025g Kluyveromyces lactis high-affinity iron permease FTR1 XP_451132.1 266917 D 28985 CDS KLLA0_A03047g 2896819 269553..271256 A 1 NC_006037.1 similar to uniprot|Q758P8 Ashbya gossypii AEL295C AEL295Cp and some similarites with YPR008W uniprot|Q12753 Saccharomyces cerevisiae; uncharacterized protein 271256 2896819 KLLA0_A03047g Kluyveromyces lactis uncharacterized protein XP_451133.1 269553 D 28985 CDS KLLA0_A03069g 2896840 complement(271516..274203) A 1 NC_006037.1 highly similar to uniprot|P32863 Saccharomyces cerevisiae YGL163C RAD54 DNA-dependent ATPase stimulates strand exchange by modifying the topology of double-stranded DNA involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis member of the SWI/SNF family; DNA-dependent ATPase RAD54 274203 2896840 KLLA0_A03069g Kluyveromyces lactis DNA-dependent ATPase RAD54 XP_451134.1 271516 R 28985 CDS KLLA0_A03091g 2896583 276333..277484 A 1 NC_006037.1 some similarities with uniprot|Q12286 Saccharomyces cerevisiae YPR009W SUT2 Involved in sterol uptake homologous to SUT1; uncharacterized protein 277484 2896583 KLLA0_A03091g Kluyveromyces lactis uncharacterized protein XP_451135.1 276333 D 28985 CDS KLLA0_A03113g 2896353 complement(277880..278677) A 1 NC_006037.1 weakly similar to uniprot|P53108 Saccharomyces cerevisiae YGL161C YIP5 Protein that interacts with Rab GTPases computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport; uncharacterized protein 278677 2896353 KLLA0_A03113g Kluyveromyces lactis uncharacterized protein XP_451136.1 277880 R 28985 CDS KLLA0_A03135g 2896590 279951..281165 A 1 NC_006037.1 similar to uniprot|P32579 Saccharomyces cerevisiae YGL169W SUA5 Protein required for respiratory growth null mutation suppresses the Cyc1p translation defect caused by the presence of an aberrant ATG codon upstream of the correct start; threonylcarbamoyladenylate synthase 281165 2896590 KLLA0_A03135g Kluyveromyces lactis threonylcarbamoyladenylate synthase XP_451137.1 279951 D 28985 CDS KLLA0_A03157g 2896793 complement(281313..284129) A 1 NC_006037.1 uniprot|O74296 Kluyveromyces lactis KlPMR1 Ca++ ATPase; Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1 284129 2896793 KLLA0_A03157g Kluyveromyces lactis Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1 XP_451138.1 281313 R 28985 CDS KLLA0_A03179g 2896338 complement(285228..286244) A 1 NC_006037.1 weakly similar to uniprot|P36027 Saccharomyces cerevisiae YLR332W MID2 Protein required for mating; uncharacterized protein 286244 2896338 KLLA0_A03179g Kluyveromyces lactis uncharacterized protein XP_451139.1 285228 R 28985 CDS KLLA0_A03201g 2896829 complement(287031..288167) A 1 NC_006037.1 some similarities with uniprot|Q04951 Saccharomyces cerevisiae YMR305C; uncharacterized protein 288167 2896829 KLLA0_A03201g Kluyveromyces lactis uncharacterized protein XP_451140.1 287031 R 28985 CDS KLLA0_A03223g 2896463 290002..292035 A 1 NC_006037.1 similar to uniprot|P39932 Saccharomyces cerevisiae YDR536W STL1 Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock; uncharacterized protein 292035 2896463 KLLA0_A03223g Kluyveromyces lactis uncharacterized protein XP_451141.1 290002 D 28985 CDS KLLA0_A03245g 2896541 complement(292179..293015) A 1 NC_006037.1 highly similar to uniprot|Q12009 Saccharomyces cerevisiae YDL201W TRM8 Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA; tRNA (guanine46-N7)-methyltransferase 293015 2896541 KLLA0_A03245g Kluyveromyces lactis tRNA (guanine46-N7)-methyltransferase XP_451142.1 292179 R 28985 CDS KLLA0_A03267g 2896857 complement(293329..294066) A 1 NC_006037.1 similar to uniprot|P36521 Saccharomyces cerevisiae YDL202W MRPL11 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein uL10m 294066 2896857 KLLA0_A03267g Kluyveromyces lactis mitochondrial 54S ribosomal protein uL10m XP_451143.2 293329 R 28985 CDS KLLA0_A03289g 2896801 complement(294825..295898) A 1 NC_006037.1 weakly similar to uniprot|P47177 Saccharomyces cerevisiae YJR149W; uncharacterized protein 295898 2896801 KLLA0_A03289g Kluyveromyces lactis uncharacterized protein XP_451144.1 294825 R 28985 CDS KLLA0_A03311g 2896606 296290..297294 A 1 NC_006037.1 uniprot|O60012 Kluyveromyces lactis Putative sulfate transporter; uncharacterized protein 297294 2896606 KLLA0_A03311g Kluyveromyces lactis uncharacterized protein XP_451145.1 296290 D 28985 CDS KLLA0_A03333g 2896335 complement(297542..299665) A 1 NC_006037.1 highly similar to uniprot|Q01574 Saccharomyces cerevisiae YAL054C ACS1 Acetyl-coA synthetase isoform expressed during growth on nonfermentable carbon sources and under aerobic conditions; acetate--CoA ligase 1 299665 2896335 KLLA0_A03333g Kluyveromyces lactis acetate--CoA ligase 1 XP_451146.1 297542 R 28985 CDS KLLA0_A03355g 2896803 301465..303819 A 1 NC_006037.1 similar to uniprot|P39719 Saccharomyces cerevisiae YAL053W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; flavin adenine dinucleotide transporter FLC2 303819 2896803 KLLA0_A03355g Kluyveromyces lactis flavin adenine dinucleotide transporter FLC2 XP_451147.1 301465 D 28985 CDS KLLA0_A03377g 2896686 complement(304117..304863) A 1 NC_006037.1 similar to uniprot|P39721 Saccharomyces cerevisiae YAL049C; protein AIM2 304863 2896686 KLLA0_A03377g Kluyveromyces lactis protein AIM2 XP_451148.1 304117 R 28985 CDS KLLA0_A03399g 2896533 305616..308153 A 1 NC_006037.1 weakly similar to uniprot|P39720 Saccharomyces cerevisiae YAL051W OAF1 Oleate-activated transcription factor acts alone and as a heterodimer with Pip2p activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; uncharacterized protein 308153 2896533 KLLA0_A03399g Kluyveromyces lactis uncharacterized protein XP_451149.1 305616 D 28985 CDS KLLA0_A03421g 2896351 308414..311056 A 1 NC_006037.1 weakly similar to uniprot|P39720 Saccharomyces cerevisiae YAL051W OAF1 Oleate-activated transcription factor acts alone and as a heterodimer with Pip2p activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; uncharacterized protein 311056 2896351 KLLA0_A03421g Kluyveromyces lactis uncharacterized protein XP_451150.1 308414 D 28985 CDS KLLA0_A03443g 2896551 311628..314555 A 1 NC_006037.1 similar to uniprot|Q758X5 Ashbya gossypii ADR403C ADR403Cp and weakly similar to YAL051W uniprot|P39720 Saccharomyces cerevisiae YAL051W OAF1 Oleate-activated transcription factor acts alone and as a heterodimer with Pip2p activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; uncharacterized protein 314555 2896551 KLLA0_A03443g Kluyveromyces lactis uncharacterized protein XP_451151.1 311628 D 28985 CDS KLLA0_A03465g 2896350 complement(314573..316552) A 1 NC_006037.1 highly similar to uniprot|P39722 Saccharomyces cerevisiae YAL048C GEM1 Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology cells lacking Gem1p contain collapsed globular or grape-like mitochondria not required for pheromone-induced cell death; ERMES complex Ca(2+)-binding regulatory GTPase GEM1 316552 2896350 KLLA0_A03465g Kluyveromyces lactis ERMES complex Ca(2+)-binding regulatory GTPase GEM1 XP_451152.1 314573 R 28985 CDS KLLA0_A03487g 2896346 join(316951..316953,317116..317940) A 1 NC_006037.1 similar to uniprot|P21242 Saccharomyces cerevisiae YOR362C PRE10 20S proteasome alpha-type subunit; proteasome core particle subunit alpha 7 317940 2896346 KLLA0_A03487g Kluyveromyces lactis proteasome core particle subunit alpha 7 XP_451153.2 316951 D 28985 CDS KLLA0_A03509g 2896552 complement(318067..320397) A 1 NC_006037.1 weakly similar to uniprot|P39723 Saccharomyces cerevisiae YAL047C SPC72 Component of the cytoplasmic Tub4p (gamma-tubulin) complex binds spindle pole bodies and links them to microtubules has roles in astral microtubule formation and stabilization; gamma-tubulin complex subunit SPC72 320397 2896552 KLLA0_A03509g Kluyveromyces lactis gamma-tubulin complex subunit SPC72 XP_451154.1 318067 R 28985 CDS KLLA0_A03531g 2896595 320828..323026 A 1 NC_006037.1 similar to uniprot|P06103 Saccharomyces cerevisiae YOR361C PRT1 Subunit of the core complex of translation initiation factor 3(eIF3) essential for translation part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes; translation initiation factor eIF3 core subunit b 323026 2896595 KLLA0_A03531g Kluyveromyces lactis translation initiation factor eIF3 core subunit b XP_451155.1 320828 D 28985 CDS KLLA0_A03553g 2896572 complement(323382..323657) A 1 NC_006037.1 similar to uniprot|P39724 Saccharomyces cerevisiae YAL046C; uncharacterized protein 323657 2896572 KLLA0_A03553g Kluyveromyces lactis uncharacterized protein XP_451156.1 323382 R 28985 CDS KLLA0_A03575g 2896799 323999..324361 A 1 NC_006037.1 similar to uniprot|Q3E793 Saccharomyces cerevisiae YAL044W-A Similar to pombe uvi31 putative DNA repair protein; uncharacterized protein 324361 2896799 KLLA0_A03575g Kluyveromyces lactis uncharacterized protein XP_451157.1 323999 D 28985 CDS KLLA0_A03597g 2896641 complement(324491..325018) A 1 NC_006037.1 similar to uniprot|P39726 Saccharomyces cerevisiae YAL044C GCV3 H subunit of the mitochondrial glycine decarboxylase complex required for the catabolism of glycine to 5 10-methylene-THF expression is regulated by levels of levels of 5 10-methylene-THF in the cytoplasm; glycine decarboxylase subunit H 325018 2896641 KLLA0_A03597g Kluyveromyces lactis glycine decarboxylase subunit H XP_451158.1 324491 R 28985 CDS KLLA0_A03619g 2896545 326530..328080 A 1 NC_006037.1 similar to uniprot|P06776 Saccharomyces cerevisiae YOR360C PDE2 High-affinity cyclic AMP phosphodiesterase component of the cAMP-dependent protein kinase signaling system protects the cell from extracellular cAMP contains readthrough motif surrounding termination codon; 3',5'-cyclic-nucleotide phosphodiesterase PDE2 328080 2896545 KLLA0_A03619g Kluyveromyces lactis 3',5'-cyclic-nucleotide phosphodiesterase PDE2 XP_451159.1 326530 D 28985 CDS KLLA0_A03641g 2896691 complement(328807..330186) A 1 NC_006037.1 some similarities with uniprot|Q08831 Saccharomyces cerevisiae YOR359W VTS1; uncharacterized protein 330186 2896691 KLLA0_A03641g Kluyveromyces lactis uncharacterized protein XP_451160.1 328807 R 28985 CDS KLLA0_A03663g 2896615 complement(331039..333513) A 1 NC_006037.1 similar to uniprot|Q01329 Saccharomyces cerevisiae YAL043C PTA1 Subunit of holo-CPF a multiprotein complex and functional homolog of mammalian CPSF required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends involved in pre-tRNA processing binds to the phosphorylated CTD of RNAPII; RNA-processing protein PTA1 333513 2896615 KLLA0_A03663g Kluyveromyces lactis RNA-processing protein PTA1 XP_451161.1 331039 R 28985 CDS KLLA0_A03696g 2896679 complement(334065..334535) A 1 NC_006037.1 highly similar to uniprot|Q758Y6 Ashbya gossypii ADR391W ADR391Wp and some similarites with uniprot|Q02516 Saccharomyces cerevisiae YOR358W HAP5 Subunit of the heme-activated glucose-repressed Hap2/3/4/5 CCAAT-binding complex a transcriptional activator and global regulator of respiratory gene expression required for assembly and DNA binding activity of the complex; uncharacterized protein 334535 2896679 KLLA0_A03696g Kluyveromyces lactis uncharacterized protein XP_451163.1 334065 R 28985 CDS KLLA0_A03718g 2896685 334828..335322 A 1 NC_006037.1 similar to uniprot|Q08826 Saccharomyces cerevisiae YOR357C; uncharacterized protein 335322 2896685 KLLA0_A03718g Kluyveromyces lactis uncharacterized protein XP_451164.1 334828 D 28985 CDS KLLA0_A03740g 2896800 complement(335548..337287) A 1 NC_006037.1 similar to uniprot|P38925 Saccharomyces cerevisiae YOL122C SMF1 Divalent metal ion transporter; divalent metal ion transporter SMF1 337287 2896800 KLLA0_A03740g Kluyveromyces lactis divalent metal ion transporter SMF1 XP_451165.1 335548 R 28985 CDS KLLA0_A03806g 2896802 complement(338807..340615) A 1 NC_006037.1 highly similar to uniprot|P06782 Saccharomyces cerevisiae YDR477W SNF1 Protein serine/threonine kinase required for release from glucose repression invertase expression sporulation and for expression of catabolite-repressed genes when glucose is limiting regulates Adr1p-dependent transcription primarily at the level of chromatin binding; AMP-activated serine/threonine-protein kinase catalytic subunit SNF1 340615 2896802 KLLA0_A03806g Kluyveromyces lactis AMP-activated serine/threonine-protein kinase catalytic subunit SNF1 XP_451166.1 338807 R 28985 CDS KLLA0_A03883g 2896684 join(344642..344725,344850..345098) A 1 NC_006037.1 highly similar to uniprot|P33328 Saccharomyces cerevisiae YOR327C SNC2 mediate the targeting and transport of secretory proteins vesicle-associated membrane protein (synaptobrevin) homolog; uncharacterized protein 345098 2896684 KLLA0_A03883g Kluyveromyces lactis uncharacterized protein XP_451170.1 344642 D 28985 CDS KLLA0_A03905g 2896682 complement(345818..350470) A 1 NC_006037.1 similar to uniprot|P19524 Saccharomyces cerevisiae YOR326W MYO2 One of two type V myosins involved in polarized distribution of mitochondria required for mitochondrion and vacuole inheritance and nuclear spindle orientation moves multiple cargo; uncharacterized protein 350470 2896682 KLLA0_A03905g Kluyveromyces lactis uncharacterized protein XP_451171.1 345818 R 28985 CDS KLLA0_A03938g 2896812 351240..352502 A 1 NC_006037.1 some similarities with uniprot|P39734 Saccharomyces cerevisiae YAL028W FRT2 Tail-anchored endoplasmic reticulum membrane protein; uncharacterized protein 352502 2896812 KLLA0_A03938g Kluyveromyces lactis uncharacterized protein XP_451173.1 351240 D 28985 CDS KLLA0_A03960g 2896783 join(352856..352866,352938..353796) A 1 NC_006037.1 similar to uniprot|P39735 Saccharomyces cerevisiae YAL027W; DNA-binding protein SAW1 353796 2896783 KLLA0_A03960g Kluyveromyces lactis DNA-binding protein SAW1 XP_451174.2 352856 D 28985 CDS KLLA0_A03982g 2896796 354208..355551 A 1 NC_006037.1 highly similar to uniprot|P54885 Saccharomyces cerevisiae YOR323C PRO2 Gamma-glutamyl phosphate reductase catalyzes the second step in proline biosynthesis; glutamate-5-semialdehyde dehydrogenase 355551 2896796 KLLA0_A03982g Kluyveromyces lactis glutamate-5-semialdehyde dehydrogenase XP_451175.1 354208 D 28985 CDS KLLA0_A04015g 2896355 complement(355624..359655) A 1 NC_006037.1 highly similar to uniprot|P39524 Saccharomyces cerevisiae YAL026C DRS2 Integral membrane Ca(2)-ATPase potential aminophospholipid translocase required to form a specific class of secretory vesicles that accumulate upon actin cytoskeleton disruption mutation affects maturation of the 18S rRNA; aminophospholipid-translocating P4-type ATPase DRS2 359655 2896355 KLLA0_A04015g Kluyveromyces lactis aminophospholipid-translocating P4-type ATPase DRS2 XP_451177.1 355624 R 28985 CDS KLLA0_A04037g 2896788 complement(359981..360889) A 1 NC_006037.1 some similarities with uniprot|P10962 Saccharomyces cerevisiae YAL025C MAK16 Essential nuclear protein required for normal concentration of free 60S ribosomal subunits required for maintenance of M1 satellite double- stranded RNA of the L-A virus; ribosome biosynthesis protein MAK16 360889 2896788 KLLA0_A04037g Kluyveromyces lactis ribosome biosynthesis protein MAK16 XP_451178.1 359981 R 28985 CDS KLLA0_A04059g 2896846 complement(361328..365428) A 1 NC_006037.1 similar to uniprot|P07866 Saccharomyces cerevisiae YAL024C LTE1 Putative GDP/GTP exchange factor required for mitotic exit at low temperatures acts as a guanine nucleotide exchange factor (GEF) for Tem1p which is a key regulator of mitotic exit physically associates with Ras2p-GTP; mitotic regulator LTE1 365428 2896846 KLLA0_A04059g Kluyveromyces lactis mitotic regulator LTE1 XP_451179.1 361328 R 28985 CDS KLLA0_A04081g 2896537 366969..368552 A 1 NC_006037.1 conserved hypothetical protein; uncharacterized protein 368552 2896537 KLLA0_A04081g Kluyveromyces lactis uncharacterized protein XP_451180.1 366969 D 28985 CDS KLLA0_A04103g 2896534 369258..371615 A 1 NC_006037.1 similar to uniprot|Q12502 Saccharomyces cerevisiae YOR322C; uncharacterized protein 371615 2896534 KLLA0_A04103g Kluyveromyces lactis uncharacterized protein XP_451181.1 369258 D 28985 CDS KLLA0_A04125g 2896536 372826..374589 A 1 NC_006037.1 conserved hypothetical protein; uncharacterized protein 374589 2896536 KLLA0_A04125g Kluyveromyces lactis uncharacterized protein XP_451182.1 372826 D 28985 CDS KLLA0_A04147g 2896678 complement(374897..375985) A 1 NC_006037.1 similar to uniprot|Q7LIE3 Saccharomyces cerevisiae YDR214W AHA1 Activator of Heat Shock Protein 90 ATPase; uncharacterized protein 375985 2896678 KLLA0_A04147g Kluyveromyces lactis uncharacterized protein XP_451183.1 374897 R 28985 CDS KLLA0_A04169g 2896359 complement(376273..378600) A 1 NC_006037.1 similar to uniprot|Q05958 Saccharomyces cerevisiae YLR228C ECM22 Sterol regulatory element binding protein regulates transcription of the sterol biosynthetic genes ERG2 and ERG3 member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors homologous to Upc2p; uncharacterized protein 378600 2896359 KLLA0_A04169g Kluyveromyces lactis uncharacterized protein XP_451184.1 376273 R 28985 CDS KLLA0_A04191g 2896562 complement(379492..381171) A 1 NC_006037.1 highly similar to uniprot|P12612 Saccharomyces cerevisiae YDR212W TCP1 tailless complex polypeptide 1 chaperonin subunit alpha; chaperonin-containing T-complex alpha subunit TCP1 381171 2896562 KLLA0_A04191g Kluyveromyces lactis chaperonin-containing T-complex alpha subunit TCP1 XP_451185.1 379492 R 28985 CDS KLLA0_A04213g 2896618 complement(382243..382818) A 1 NC_006037.1 highly similar to uniprot|P19073 Saccharomyces cerevisiae YLR229C CDC42 Small rho-like GTPase essential for establishment and maintenance of cell polarity mutants have defects in the organization of actin and septin; Rho family GTPase CDC42 382818 2896618 KLLA0_A04213g Kluyveromyces lactis Rho family GTPase CDC42 XP_451186.1 382243 R 28985 CDS KLLA0_A04235g 2896625 complement(383275..385485) A 1 NC_006037.1 similar to uniprot|P32501 Saccharomyces cerevisiae YDR211W GCD6 Catalytic epsilon subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression; translation initiation factor eIF2B catalytic subunit epsilon 385485 2896625 KLLA0_A04235g Kluyveromyces lactis translation initiation factor eIF2B catalytic subunit epsilon XP_451187.1 383275 R 28985 CDS KLLA0_A04301g 2896841 complement(387006..389165) A 1 NC_006037.1 similar to uniprot|Q750P3 Ashbya gossypii AGL096W AGL096Wp and weakly similar to YDR208W uniprot|P38994 Saccharomyces cerevisiae YDR208W MSS4 Phosphatidylinositol-4-phosphate 5-kinase involved in actin cytoskeleton organization and cell morphogenesis multicopy suppressor of stt4 mutation; 1-phosphatidylinositol-4-phosphate 5-kinase 389165 2896841 KLLA0_A04301g Kluyveromyces lactis 1-phosphatidylinositol-4-phosphate 5-kinase XP_451188.1 387006 R 28985 CDS KLLA0_A04323g 2896354 391590..392201 A 1 NC_006037.1 some similarities with uniprot|Q04433 Saccharomyces cerevisiae YDR534C FIT1 Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore- iron in the cell wall; uncharacterized protein 392201 2896354 KLLA0_A04323g Kluyveromyces lactis uncharacterized protein XP_451189.1 391590 D 28985 CDS KLLA0_A04345g 2896791 394997..395902 A 1 NC_006037.1 some similarities with uniprot|Q04433 Saccharomyces cerevisiae YDR534C FIT1 Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore- iron in the cell wall; uncharacterized protein 395902 2896791 KLLA0_A04345g Kluyveromyces lactis uncharacterized protein XP_451190.1 394997 D 28985 CDS KLLA0_A04367g 2896357 complement(397648..398133) A 1 NC_006037.1 similar to uniprot|Q08906 Saccharomyces cerevisiae YOR382W FIT2 Mannoprotein; uncharacterized protein 398133 2896357 KLLA0_A04367g Kluyveromyces lactis uncharacterized protein XP_451191.1 397648 R 28985 CDS KLLA0_A04389g 2896352 400113..400775 A 1 NC_006037.1 weakly similar to uniprot|Q04734 Saccharomyces cerevisiae YMR063W; uncharacterized protein 400775 2896352 KLLA0_A04389g Kluyveromyces lactis uncharacterized protein XP_451192.1 400113 D 28985 CDS KLLA0_A04411g 2896674 complement(400945..401796) A 1 NC_006037.1 similar to uniprot|Q05892 Saccharomyces cerevisiae YLR290C; ubiquinone biosynthesis protein COQ11 401796 2896674 KLLA0_A04411g Kluyveromyces lactis ubiquinone biosynthesis protein COQ11 XP_451193.1 400945 R 28985 CDS KLLA0_A04433g 2896672 complement(402462..403532) A 1 NC_006037.1 highly similar to uniprot|Q74ZF9 Ashbya gossypii AGR292C AGR292Cp and similar to YLR291C uniprot|P32502 Saccharomyces cerevisiae YLR291C GCD7 Beta subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression; uncharacterized protein 403532 2896672 KLLA0_A04433g Kluyveromyces lactis uncharacterized protein XP_451194.1 402462 R 28985 CDS KLLA0_A04499g 2896681 complement(404732..405376) A 1 NC_006037.1 highly similar to uniprot|P32836 Saccharomyces cerevisiae YOR185C GSP2 GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization RNA processing and transport interacts with Kap121p Kap123p and Pdr6p (karyophilin betas) Gsp1p homolog that is not required for viability; uncharacterized protein 405376 2896681 KLLA0_A04499g Kluyveromyces lactis uncharacterized protein XP_451197.1 404732 R 28985 CDS KLLA0_A04521g 2896831 complement(405802..406581) A 1 NC_006037.1 conserved hypothetical protein; uncharacterized protein 406581 2896831 KLLA0_A04521g Kluyveromyces lactis uncharacterized protein XP_451198.1 405802 R 28985 CDS KLLA0_A04543g 2896554 complement(406920..407249) A 1 NC_006037.1 similar to uniprot|Q12349 Saccharomyces cerevisiae YLR295C ATP14 Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis; uncharacterized protein 407249 2896554 KLLA0_A04543g Kluyveromyces lactis uncharacterized protein XP_451199.1 406920 R 28985 CDS KLLA0_A04565g 2896634 complement(407581..408150) A 1 NC_006037.1 weakly similar to uniprot|Q05900 Saccharomyces cerevisiae YLR298C YHC1 U1 snRNP protein required for pre-mRNA splicing; uncharacterized protein 408150 2896634 KLLA0_A04565g Kluyveromyces lactis uncharacterized protein XP_451200.1 407581 R 28985 CDS KLLA0_A04587g 2896784 408699..409991 A 1 NC_006037.1 highly similar to uniprot|P02992 Saccharomyces cerevisiae YOR187W TUF1 Mitochondrial translation elongation factor Tu comprises both GTPase and guanine nucleotide exchange factor activities while these activities are found in separate proteins in S. pombe and humans; uncharacterized protein 409991 2896784 KLLA0_A04587g Kluyveromyces lactis uncharacterized protein XP_451201.1 408699 D 28985 CDS KLLA0_A04609g 2896675 complement(411494..412765) A 1 NC_006037.1 weakly similar to uniprot|Q6Q5F4 Saccharomyces cerevisiae YPR015C; uncharacterized protein 412765 2896675 KLLA0_A04609g Kluyveromyces lactis uncharacterized protein XP_451202.1 411494 R 28985 CDS KLLA0_A04620g 9487407 complement(413642..413914) A 1 NC_006037.1 no similarity; uncharacterized protein 413914 9487407 KLLA0_A04620g Kluyveromyces lactis uncharacterized protein XP_002999346.1 413642 R 28985 CDS KLLA0_A04631g 2896673 complement(415070..416809) A 1 NC_006037.1 weakly similar to uniprot|Q04602 Saccharomyces cerevisiae YDR119W Uncharacterized transporter; uncharacterized protein 416809 2896673 KLLA0_A04631g Kluyveromyces lactis uncharacterized protein XP_451203.1 415070 R 28985 CDS KLLA0_A04653g 2896785 complement(417313..419415) A 1 NC_006037.1 similar to uniprot|P48234 Saccharomyces cerevisiae YGR145W ENP2 Essential nucleolar protein of unknown function contains WD repeats interacts with Mpp10p and Bfr2p and has homology to Spb1p; ribosome biosynthesis protein ENP2 419415 2896785 KLLA0_A04653g Kluyveromyces lactis ribosome biosynthesis protein ENP2 XP_451204.1 417313 R 28985 CDS KLLA0_A04708g 2896571 complement(420317..421372) A 1 NC_006037.1 highly similar to uniprot|P53290 Saccharomyces cerevisiae YGR163W GTR2 Cytoplasmic GTP binding protein functions as a negative regulator of the Ran/Tc4 GTPase cycle downstream of its binding partner and homolog Gtr1p homolog of human RagC and RagD proteins; uncharacterized protein 421372 2896571 KLLA0_A04708g Kluyveromyces lactis uncharacterized protein XP_451206.1 420317 R 28985 CDS KLLA0_A04730g 2896573 complement(421863..424928) A 1 NC_006037.1 some similarities with uniprot|P39935 Saccharomyces cerevisiae YGR162W TIF4631 also called eIF4 (eIF-4) gamma mRNA cap-binding protein (eIF-4F) 150K subunit highly homologous to Tif4632p homologs of mammalian p220; uncharacterized protein 424928 2896573 KLLA0_A04730g Kluyveromyces lactis uncharacterized protein XP_451207.1 421863 R 28985 CDS KLLA0_A04752g 2896813 complement(425610..426824) A 1 NC_006037.1 highly similar to uniprot|Q01939 Saccharomyces cerevisiae YGL048C RPT6 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; proteasome regulatory particle base subunit RPT6 426824 2896813 KLLA0_A04752g Kluyveromyces lactis proteasome regulatory particle base subunit RPT6 XP_451208.1 425610 R 28985 CDS KLLA0_A04774g 2896531 427263..427856 A 1 NC_006037.1 similar to uniprot|P53178 Saccharomyces cerevisiae YGL047W; N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase catalytic subunit ALG13 427856 2896531 KLLA0_A04774g Kluyveromyces lactis N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase catalytic subunit ALG13 XP_451209.1 427263 D 28985 CDS KLLA0_A04796g 2896592 complement(427861..428502) A 1 NC_006037.1 similar to uniprot|Q754R6 Ashbya gossypii AFR006C AFR006Cp and weakly similar to YGL020C uniprot|P53192 Saccharomyces cerevisiae YGL020C MDM39 Protein involved in determination of mitochondrial structure; GET complex subunit GET1 428502 2896592 KLLA0_A04796g Kluyveromyces lactis GET complex subunit GET1 XP_451210.1 427861 R 28985 CDS KLLA0_A04818g 2896549 429275..430108 A 1 NC_006037.1 similar to uniprot|P43639 Saccharomyces cerevisiae YGL019W CKB1 beta (38kDa) subunit of protein kinase CK2; casein kinase 2 regulatory subunit CKB1 430108 2896549 KLLA0_A04818g Kluyveromyces lactis casein kinase 2 regulatory subunit CKB1 XP_451211.1 429275 D 28985 CDS KLLA0_A04840g 2896446 complement(430541..431113) A 1 NC_006037.1 similar to uniprot|P53193 Saccharomyces cerevisiae YGL018C JAC1 Molecular chaperone involved with partner Ssq1p in assembly of Fe/S clusters and in mitochondrial iron metabolism contains a J domain typical to J-type chaperones localizes to the mitochondrial matrix; J-type chaperone JAC1 431113 2896446 KLLA0_A04840g Kluyveromyces lactis J-type chaperone JAC1 XP_451212.2 430541 R 28985 CDS KLLA0_A04862g 2896777 431710..433221 A 1 NC_006037.1 similar to uniprot|P16639 Saccharomyces cerevisiae YGL017W ATE1 Arginyl-tRNA-protein transferase catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway; arginyltransferase 433221 2896777 KLLA0_A04862g Kluyveromyces lactis arginyltransferase XP_451213.1 431710 D 28985 CDS KLLA0_A04884g 2896815 433581..436760 A 1 NC_006037.1 similar to uniprot|P32767 Saccharomyces cerevisiae YGL016W KAP122 Karyopherin beta responsible for import of the Toa1p-Toa2p complex into the nucleus binds to nucleoporins Nup1p and Nup2p may play a role in regulation of pleiotropic drug resistance; uncharacterized protein 436760 2896815 KLLA0_A04884g Kluyveromyces lactis uncharacterized protein XP_451214.1 433581 D 28985 CDS KLLA0_A04906g 2896839 437523..438965 A 1 NC_006037.1 similar to uniprot|P53090 Saccharomyces cerevisiae YGL202W ARO8 Aromatic aminotransferase expression is regulated by general control of amino acid biosynthesis; uncharacterized protein 438965 2896839 KLLA0_A04906g Kluyveromyces lactis uncharacterized protein XP_451215.1 437523 D 28985 CDS KLLA0_A04928g 2896848 439349..441934 A 1 NC_006037.1 similar to uniprot|P32479 Saccharomyces cerevisiae YBL008W HIR1 Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A H2B H3 and H4 genes contributes to nucleosome formation heterochromatic gene silencing and formation of functional kinetochores; uncharacterized protein 441934 2896848 KLLA0_A04928g Kluyveromyces lactis uncharacterized protein XP_451216.1 439349 D 28985 CDS KLLA0_A04961g 2896339 442461..444818 A 1 NC_006037.1 highly similar to uniprot|P07264 Saccharomyces cerevisiae YGL009C LEU1 Isopropylmalate isomerase catalyzes the second step in the leucine biosynthesis pathway; 3-isopropylmalate dehydratase LEU1 444818 2896339 KLLA0_A04961g Kluyveromyces lactis 3-isopropylmalate dehydratase LEU1 XP_451218.1 442461 D 28985 CDS KLLA0_A04983g 2896806 complement(445032..448787) A 1 NC_006037.1 similar to uniprot|P32790 Saccharomyces cerevisiae YBL007C SLA1 Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton contains 3 SH3 domains interacts with proteins regulating actin dynamics and with proteins required for endocytosis; cytoskeletal protein-binding protein SLA1 448787 2896806 KLLA0_A04983g Kluyveromyces lactis cytoskeletal protein-binding protein SLA1 XP_451219.1 445032 R 28985 CDS KLLA0_A05005g 2896804 complement(449590..450111) A 1 NC_006037.1 similar to uniprot|P25338 Saccharomyces cerevisiae YGL010W; uncharacterized protein 450111 2896804 KLLA0_A05005g Kluyveromyces lactis uncharacterized protein XP_451220.1 449590 R 28985 CDS KLLA0_A05027g 2896519 450398..451138 A 1 NC_006037.1 highly similar to uniprot|P21243 Saccharomyces cerevisiae YGL011C SCL1 Proteasome subunit YC7alpha/Y8 (protease yscE subunit 7); proteasome core particle subunit alpha 1 451138 2896519 KLLA0_A05027g Kluyveromyces lactis proteasome core particle subunit alpha 1 XP_451221.1 450398 D 28985 CDS KLLA0_A05049g 2896825 complement(451480..451926) A 1 NC_006037.1 weakly similar to uniprot|P38210 Saccharomyces cerevisiae YBL006C LDB7 Protein of unknown function null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface; uncharacterized protein 451926 2896825 KLLA0_A05049g Kluyveromyces lactis uncharacterized protein XP_451222.1 451480 R 28985 CDS KLLA0_A05071g 2896703 complement(452333..453730) A 1 NC_006037.1 similar to uniprot|P25340 Saccharomyces cerevisiae YGL012W ERG4 C-24(28) sterol reductase catalyzes the final step in ergosterol biosynthesis mutants are viable but lack ergosterol; delta(24(24(1)))-sterol reductase 453730 2896703 KLLA0_A05071g Kluyveromyces lactis delta(24(24(1)))-sterol reductase XP_451223.1 452333 R 28985 CDS KLLA0_A05093g 2896822 454423..455211 A 1 NC_006037.1 highly similar to uniprot|P32379 Saccharomyces cerevisiae YGR253C PUP2 Alpha subunit of the 20S proteasome involved in ubiquitin-dependent catabolism human homolog is subunit zeta; proteasome core particle subunit alpha 5 455211 2896822 KLLA0_A05093g Kluyveromyces lactis proteasome core particle subunit alpha 5 XP_451224.1 454423 D 28985 CDS KLLA0_A05115g 2896739 complement(455456..457006) A 1 NC_006037.1 highly similar to uniprot|Q03330 Saccharomyces cerevisiae YGR252W GCN5 Histone acetyltransferase acetylates lysine 14 on histone H3 catalytic subunit of the ADA and SAGA histone acetyltransferase complexes founding member of the Gcn5p-related N-acetyltransferase superfamily; histone acetyltransferase GCN5 457006 2896739 KLLA0_A05115g Kluyveromyces lactis histone acetyltransferase GCN5 XP_451225.1 455456 R 28985 CDS KLLA0_A05137g 2896361 complement(457440..459251) A 1 NC_006037.1 similar to uniprot|P38862 Saccharomyces cerevisiae YHR171W ATG7 Autophagy-related protein that is a member of the E1 family of ubiquitin-activating enzymes mediates the conjugation of Atg12p with Atg5p a required step in the formation of autophagosomes; uncharacterized protein 459251 2896361 KLLA0_A05137g Kluyveromyces lactis uncharacterized protein XP_451226.1 457440 R 28985 CDS KLLA0_A05159g 2896504 complement(459573..461117) A 1 NC_006037.1 similar to uniprot|P38861 Saccharomyces cerevisiae YHR170W NMD3 Protein involved in nuclear export of the large ribosomal subunit acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex; ribosome-binding protein NMD3 461117 2896504 KLLA0_A05159g Kluyveromyces lactis ribosome-binding protein NMD3 XP_451227.1 459573 R 28985 CDS KLLA0_A05181g 2896741 complement(461373..461966) A 1 NC_006037.1 similar to uniprot|P53317 Saccharomyces cerevisiae YGR251W Protein required for cell viability; uncharacterized protein 461966 2896741 KLLA0_A05181g Kluyveromyces lactis uncharacterized protein XP_451228.1 461373 R 28985 CDS KLLA0_A05203g 2896757 complement(462167..463474) A 1 NC_006037.1 highly similar to uniprot|P38719 Saccharomyces cerevisiae YHR169W DBP8 Putative ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 40S ribosomal subunit; ATP-dependent RNA helicase DBP8 463474 2896757 KLLA0_A05203g Kluyveromyces lactis ATP-dependent RNA helicase DBP8 XP_451229.1 462167 R 28985 CDS KLLA0_A05225g 2896768 complement(463760..465448) A 1 NC_006037.1 similar to uniprot|P38860 Saccharomyces cerevisiae YHR168W MTG2 Putative GTPase member of the Obg family peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit required for mitochondrial translation possibly via a role in ribosome assembly; uncharacterized protein 465448 2896768 KLLA0_A05225g Kluyveromyces lactis uncharacterized protein XP_451230.1 463760 R 28985 CDS KLLA0_A05247g 2896700 complement(465702..466481) A 1 NC_006037.1 some similarities with uniprot|O13539 Saccharomyces cerevisiae YHR167W THP2 affects transcription elongation; uncharacterized protein 466481 2896700 KLLA0_A05247g Kluyveromyces lactis uncharacterized protein XP_451231.2 465702 R 28985 CDS KLLA0_A05258g 2896720 466776..468674 A 1 NC_006037.1 similar to uniprot|P16522 Saccharomyces cerevisiae YHR166C CDC23 Subunit of the anaphase-promoting complex/cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition; anaphase promoting complex subunit CDC23 468674 2896720 KLLA0_A05258g Kluyveromyces lactis anaphase promoting complex subunit CDC23 XP_451232.1 466776 D 28985 CDS KLLA0_A05280g 2896628 469130..476365 A 1 NC_006037.1 highly similar to uniprot|P33334 Saccharomyces cerevisiae YHR165C PRP8 Component of the U4/U6-U5 snRNP complex involved in the second catalytic step of splicing; U4/U6-U5 snRNP complex subunit PRP8 476365 2896628 KLLA0_A05280g Kluyveromyces lactis U4/U6-U5 snRNP complex subunit PRP8 XP_451233.1 469130 D 28985 CDS KLLA0_A05302g 2896808 476757..477878 A 1 NC_006037.1 no similarity; uncharacterized protein 477878 2896808 KLLA0_A05302g Kluyveromyces lactis uncharacterized protein XP_451234.1 476757 D 28985 CDS KLLA0_A05324g 2896765 478337..482674 A 1 NC_006037.1 weakly similar to uniprot|P38859 Saccharomyces cerevisiae YHR164C DNA2 Essential tripartite DNA replication factor with single-stranded DNA-dependent ATPase ATP-dependent nuclease and helicase activities required for Okazaki fragment processing involved in DNA repair pathways potential Cdc28p substrate; bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2 482674 2896765 KLLA0_A05324g Kluyveromyces lactis bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2 XP_451235.1 478337 D 28985 CDS KLLA0_A05346g 2896810 485886..488510 A 1 NC_006037.1 some similarities with uniprot|P53316 Saccharomyces cerevisiae YGR250C; uncharacterized protein 488510 2896810 KLLA0_A05346g Kluyveromyces lactis uncharacterized protein XP_451236.1 485886 D 28985 CDS KLLA0_A05368g 2896774 complement(490032..491270) A 1 NC_006037.1 weakly similar to uniprot|P53050 Saccharomyces cerevisiae YGR249W; uncharacterized protein 491270 2896774 KLLA0_A05368g Kluyveromyces lactis uncharacterized protein XP_451237.1 490032 R 28985 CDS KLLA0_A05390g 2896320 complement(495847..496617) A 1 NC_006037.1 similar to uniprot|P38858 Saccharomyces cerevisiae YHR163W SOL3 Glucose-6-phosphate dehydrogenase weak multicopy suppressor of los1-1 mutation homologous to Sol2p and Sol1p; uncharacterized protein 496617 2896320 KLLA0_A05390g Kluyveromyces lactis uncharacterized protein XP_451238.1 495847 R 28985 CDS KLLA0_A05412g 2896761 complement(496866..497507) A 1 NC_006037.1 similar to uniprot|P53314 Saccharomyces cerevisiae YGR247W CPD1 Cyclic nucleotide phosphodiesterase hydrolyzes ADP-ribose 1'' 2''-cyclic phosphate to ADP- ribose 1''-phosphate no detectable phenotype is conferred by null mutation or by overexpression; 2',3'-cyclic-nucleotide 3'-phosphodiesterase 497507 2896761 KLLA0_A05412g Kluyveromyces lactis 2',3'-cyclic-nucleotide 3'-phosphodiesterase XP_451239.1 496866 R 28985 CDS KLLA0_A05434g 2896820 497874..499544 A 1 NC_006037.1 similar to uniprot|P29056 Saccharomyces cerevisiae YGR246C BRF1 TFIIIB B-related factor one of three subunits of RNA polymerase III transcription initiation factor TFIIIB binds TFIIIC and TBP and recruits RNA pol III to promoters amino-terminal half is homologous to TFIIB; transcription factor TFIIIB subunit BRF1 499544 2896820 KLLA0_A05434g Kluyveromyces lactis transcription factor TFIIIB subunit BRF1 XP_451240.1 497874 D 28985 CDS KLLA0_A05456g 2896334 500097..502376 A 1 NC_006037.1 highly similar to gnl|GLV|CAGL0F08129g Candida glabrata CAGL0F08129g and similar to YGR245C uniprot|P53313 Saccharomyces cerevisiae YGR245C SDA1 Severe Depolymerization of Actin; uncharacterized protein 502376 2896334 KLLA0_A05456g Kluyveromyces lactis uncharacterized protein XP_451241.1 500097 D 28985 CDS KLLA0_A05478g 2896758 503729..504997 A 1 NC_006037.1 highly similar to uniprot|P53312 Saccharomyces cerevisiae YGR244C LSC2 Beta subunit of succinyl-CoA ligase which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; succinate--CoA ligase (GDP-forming) subunit beta 504997 2896758 KLLA0_A05478g Kluyveromyces lactis succinate--CoA ligase (GDP-forming) subunit beta XP_451242.1 503729 D 28985 CDS KLLA0_A05500g 2896738 complement(505579..505989) A 1 NC_006037.1 similar to uniprot|P53311 Saccharomyces cerevisiae YGR243W FMP43; mitochondrial pyruvate carrier 505989 2896738 KLLA0_A05500g Kluyveromyces lactis mitochondrial pyruvate carrier XP_451243.1 505579 R 28985 CDS KLLA0_A05511g 9487488 506882..507130 A 1 NC_006037.1 no similarity; uncharacterized protein 507130 9487488 KLLA0_A05511g Kluyveromyces lactis uncharacterized protein XP_002999347.1 506882 D 28985 CDS KLLA0_A05522g 2896725 507778..509481 A 1 NC_006037.1 similar to uniprot|P53309 Saccharomyces cerevisiae YGR241C YAP1802 Yeast Assembly Polypeptide, member of AP180 protein family, binds Pan1p and clathrin; member of clathrin assembly polypeptide AP180 family; uncharacterized protein 509481 2896725 KLLA0_A05522g Kluyveromyces lactis uncharacterized protein XP_451244.1 507778 D 28985 CDS KLLA0_A05544g 2896656 510371..513349 A 1 NC_006037.1 highly similar to uniprot|P16861 Saccharomyces cerevisiae YGR240C PFK1 Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis indispensable for anaerobic growth activated by fructose-2 6-bisphosphate and AMP mutation inhibits glucose induction of cell cycle-related genes; 6-phosphofructokinase subunit alpha 513349 2896656 KLLA0_A05544g Kluyveromyces lactis 6-phosphofructokinase subunit alpha XP_451245.1 510371 D 28985 CDS KLLA0_A05566g 2896805 514368..514619 A 1 NC_006037.1 weakly similar to uniprot|Q3E7A3 Saccharomyces cerevisiae YJL133C-A; uncharacterized protein 514619 2896805 KLLA0_A05566g Kluyveromyces lactis uncharacterized protein XP_451246.1 514368 D 28985 CDS KLLA0_A05621g 2896465 complement(516514..528711) A 1 NC_006037.1 similar to uniprot|P36022 Saccharomyces cerevisiae YKR054C DYN1 Cytoplasmic heavy chain dynein microtubule motor protein required for anaphase spindle elongation involved in spindle assembly chromosome movement and spindle orientation during cell division targeted to microtubule tips by Pac1p; dynein heavy chain 528711 2896465 KLLA0_A05621g Kluyveromyces lactis dynein heavy chain XP_451249.1 516514 R 28985 CDS KLLA0_A05643g 2896319 528976..529632 A 1 NC_006037.1 similar to uniprot|Q00246 Saccharomyces cerevisiae YKR055W RHO4 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins likely to be involved in the establishment of cell polarity; Rho family GTPase RHO4 529632 2896319 KLLA0_A05643g Kluyveromyces lactis Rho family GTPase RHO4 XP_451250.1 528976 D 28985 CDS KLLA0_A05665g 2896581 529964..531700 A 1 NC_006037.1 similar to uniprot|P33753 Saccharomyces cerevisiae YKR056W TRM2 tRNA methyltransferase 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation previously thought to be an endo-exonuclease; tRNA (uracil(54)-C(5))-methyltransferase 531700 2896581 KLLA0_A05665g Kluyveromyces lactis tRNA (uracil(54)-C(5))-methyltransferase XP_451251.1 529964 D 28985 CDS KLLA0_A05687g 2896727 complement(531875..532354) A 1 NC_006037.1 no similarity; uncharacterized protein 532354 2896727 KLLA0_A05687g Kluyveromyces lactis uncharacterized protein XP_451252.1 531875 R 28985 CDS KLLA0_A05700g 2896593 join(532965..532988,533517..533756) A 1 NC_006037.1 highly similar to uniprot|P0C0V8 Saccharomyces cerevisiae YKR057W; 40S ribosomal protein eS21 533756 2896593 KLLA0_A05700g Kluyveromyces lactis 40S ribosomal protein eS21 XP_451253.1 532965 D 28985 CDS KLLA0_A05709g 2896575 534438..535670 A 1 NC_006037.1 weakly similar to uniprot|P47011 Saccharomyces cerevisiae YJL137C; uncharacterized protein 535670 2896575 KLLA0_A05709g Kluyveromyces lactis uncharacterized protein XP_451254.1 534438 D 28985 CDS KLLA0_A05731g 2896809 536243..537433 A 1 NC_006037.1 highly similar to uniprot|P10081 Saccharomyces cerevisiae YKR059W TIF1 translation initiation factor eIF4A; uncharacterized protein 537433 2896809 KLLA0_A05731g Kluyveromyces lactis uncharacterized protein XP_451255.1 536243 D 28985 CDS KLLA0_A05753g 2896826 537889..538701 A 1 NC_006037.1 similar to uniprot|P36144 Saccharomyces cerevisiae YKR060W UTP30 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA based on computational analysis of large-scale protein-protein interaction data; uncharacterized protein 538701 2896826 KLLA0_A05753g Kluyveromyces lactis uncharacterized protein XP_451256.1 537889 D 28985 CDS KLLA0_A05775g 2896827 538934..540268 A 1 NC_006037.1 similar to uniprot|P33550 Saccharomyces cerevisiae YKR061W KTR2 Mannosyltransferase involved in N-linked protein glycosylation member of the KRE2/MNT1 mannosyltransferase family; uncharacterized protein 540268 2896827 KLLA0_A05775g Kluyveromyces lactis uncharacterized protein XP_451257.1 538934 D 28985 CDS KLLA0_A05797g 2896584 complement(540318..540920) A 1 NC_006037.1 highly similar to uniprot|Q75BM1 Ashbya gossypii ACR250W ACR250Wp and similar to YJL140W uniprot|P20433 Saccharomyces cerevisiae YJL140W RPB4 RNA polymerase II subunit B32 forms two subunit dissociable complex with Rpb7p dispensable under some environmental conditions involved in export of mRNA to cytoplasm under stress conditions; DNA-directed RNA polymerase II subunit RPB4 540920 2896584 KLLA0_A05797g Kluyveromyces lactis DNA-directed RNA polymerase II subunit RPB4 XP_451258.1 540318 R 28985 CDS KLLA0_A05819g 2896588 541545..543659 A 1 NC_006037.1 similar to uniprot|P14680 Saccharomyces cerevisiae YJL141C YAK1 Serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signal; serine/threonine protein kinase YAK1 543659 2896588 KLLA0_A05819g Kluyveromyces lactis serine/threonine protein kinase YAK1 XP_451259.1 541545 D 28985 CDS KLLA0_A05841g 2896585 complement(543975..544439) A 1 NC_006037.1 highly similar to uniprot|P39515 Saccharomyces cerevisiae YJL143W TIM17 Mitochondrial inner membrane protein involved in protein import 16.5 kDa inner membrane protein required for import of mitochondrial precursor proteins; protein transporter TIM17 544439 2896585 KLLA0_A05841g Kluyveromyces lactis protein transporter TIM17 XP_451260.1 543975 R 28985 CDS KLLA0_A05852g 9487470 complement(544850..545104) A 1 NC_006037.1 no similarity; uncharacterized protein 545104 9487470 KLLA0_A05852g Kluyveromyces lactis uncharacterized protein XP_002999348.1 544850 R 28985 CDS KLLA0_A05863g 2896459 545949..547088 A 1 NC_006037.1 highly similar to uniprot|P32451 Saccharomyces cerevisiae YGR286C BIO2 Biotin synthase catalyzes the conversion of dethiobiotin to biotin which is the last step of the biotin biosynthesis pathway complements E. coli bioB mutant; biotin synthase 547088 2896459 KLLA0_A05863g Kluyveromyces lactis biotin synthase XP_451261.1 545949 D 28985 CDS KLLA0_A05885g 2896330 complement(547338..548231) A 1 NC_006037.1 similar to uniprot|P47008 Saccharomyces cerevisiae YJL145W SFH5 putative phosphatidylinositol transfer protein; uncharacterized protein 548231 2896330 KLLA0_A05885g Kluyveromyces lactis uncharacterized protein XP_451262.1 547338 R 28985 CDS KLLA0_A05907g 2896763 complement(548720..549763) A 1 NC_006037.1 weakly similar to uniprot|P46958 Saccharomyces cerevisiae YJL146W IDS2 Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation; uncharacterized protein 549763 2896763 KLLA0_A05907g Kluyveromyces lactis uncharacterized protein XP_451263.1 548720 R 28985 CDS KLLA0_A05929g 2896458 550666..551748 A 1 NC_006037.1 weakly similar to uniprot|P47007 Saccharomyces cerevisiae YJL147C; uncharacterized protein 551748 2896458 KLLA0_A05929g Kluyveromyces lactis uncharacterized protein XP_451264.1 550666 D 28985 CDS KLLA0_A05951g 2896497 552438..553298 A 1 NC_006037.1 highly similar to uniprot|Q75BM7 Ashbya gossypii ACR244C ACR244Cp and similar to YKR062W uniprot|P36145 Saccharomyces cerevisiae YKR062W TFA2 TFIIE small subunit involved in RNA polymerase II transcription initiation; transcription factor TFIIE subunit TFA2 553298 2896497 KLLA0_A05951g Kluyveromyces lactis transcription factor TFIIE subunit TFA2 XP_451265.1 552438 D 28985 CDS KLLA0_A05973g 2896329 complement(553403..553987) A 1 NC_006037.1 weakly similar to uniprot|P47006 Saccharomyces cerevisiae YJL148W RPA34 RNA polymerase I subunit A34.5; DNA-directed RNA polymerase I subunit RPA34 553987 2896329 KLLA0_A05973g Kluyveromyces lactis DNA-directed RNA polymerase I subunit RPA34 XP_451266.1 553403 R 28985 CDS KLLA0_A06017g 2896493 complement(555280..556650) A 1 NC_006037.1 similar to uniprot|Q75BM9 Ashbya gossypii ACR242W ACR242Wp and weakly similar to YKR063C uniprot|P36146 Saccharomyces cerevisiae YKR063C LAS1 Essential nuclear protein possibly involved in bud formation and morphogenesis mutants require the SSD1-v allele for viability; rRNA-processing protein LAS1 556650 2896493 KLLA0_A06017g Kluyveromyces lactis rRNA-processing protein LAS1 XP_451268.1 555280 R 28985 CDS KLLA0_A06039g 2896452 557368..559341 A 1 NC_006037.1 weakly similar to uniprot|P36023 Saccharomyces cerevisiae YKR064W; uncharacterized protein 559341 2896452 KLLA0_A06039g Kluyveromyces lactis uncharacterized protein XP_451269.1 557368 D 28985 CDS KLLA0_A06061g 2896492 complement(559396..560994) A 1 NC_006037.1 similar to uniprot|P47005 Saccharomyces cerevisiae YJL149W; SCF ubiquitin ligase complex subunit DAS1 560994 2896492 KLLA0_A06061g Kluyveromyces lactis SCF ubiquitin ligase complex subunit DAS1 XP_451270.1 559396 R 28985 CDS KLLA0_A06083g 2896450 complement(562140..562730) A 1 NC_006037.1 similar to uniprot|P36147 Saccharomyces cerevisiae YKR065C FMP18 The authentic non-tagged protein was localized to the mitochondria; uncharacterized protein 562730 2896450 KLLA0_A06083g Kluyveromyces lactis uncharacterized protein XP_451271.1 562140 R 28985 CDS KLLA0_A06105g 2896776 563147..564067 A 1 NC_006037.1 some similarities with uniprot|P25623 Saccharomyces cerevisiae YCR030C SYP1 Protein; uncharacterized protein 564067 2896776 KLLA0_A06105g Kluyveromyces lactis uncharacterized protein XP_451272.1 563147 D 28985 CDS KLLA0_A06127g 2896693 complement(564088..564597) A 1 NC_006037.1 no similarity; uncharacterized protein 564597 2896693 KLLA0_A06127g Kluyveromyces lactis uncharacterized protein XP_451273.1 564088 R 28985 CDS KLLA0_A06149g 2896701 565427..565819 A 1 NC_006037.1 similar to uniprot|P32445 Saccharomyces cerevisiae YCR028C-A RIM1 Single-stranded DNA-binding protein that is essential for mitochondrial genome maintenance Single-stranded zinc finger DNA-binding protein; uncharacterized protein 565819 2896701 KLLA0_A06149g Kluyveromyces lactis uncharacterized protein XP_451274.1 565427 D 28985 CDS KLLA0_A06171g 2896326 566176..566535 A 1 NC_006037.1 similar to uniprot|P46984 Saccharomyces cerevisiae YJL184W GON7 Protein of unknown function proposed to be involved in the transfer of mannosylphosphate groups onto N-linked oligosaccharides also proposed to be involved in responding to osmotic stress; chromatin DNA-binding EKC/KEOPS complex subunit GON7 566535 2896326 KLLA0_A06171g Kluyveromyces lactis chromatin DNA-binding EKC/KEOPS complex subunit GON7 XP_451275.1 566176 D 28985 CDS KLLA0_A06193g 2896750 566780..568096 A 1 NC_006037.1 similar to uniprot|P25621 Saccharomyces cerevisiae YCR028C FEN2 Plasma membrane H -pantothenate symporter confers sensitivity to the antifungal agent fenpropimorph; uncharacterized protein 568096 2896750 KLLA0_A06193g Kluyveromyces lactis uncharacterized protein XP_451276.1 566780 D 28985 CDS KLLA0_A06215g 2896447 568689..569927 A 1 NC_006037.1 similar to uniprot|P46985 Saccharomyces cerevisiae YJL183W MNN11 Subunit of a Golgi mannosyltransferase complex that also contains Anp1p Mnn9p Mnn10p and Hoc1p and mediates elongation of the polysaccharide mannan backbone has homology to Mnn10p; alpha-1,6-mannosyltransferase 569927 2896447 KLLA0_A06215g Kluyveromyces lactis alpha-1,6-mannosyltransferase XP_451277.1 568689 D 28985 CDS KLLA0_A06237g 2896744 570630..573071 A 1 NC_006037.1 weakly similar to uniprot|P47101 Saccharomyces cerevisiae YJR030C; uncharacterized protein 573071 2896744 KLLA0_A06237g Kluyveromyces lactis uncharacterized protein XP_451278.1 570630 D 28985 CDS KLLA0_A06259g 2896740 complement(573195..574178) A 1 NC_006037.1 similar to uniprot|P22135 Saccharomyces cerevisiae YJL180C ATP12 Molecular chaperone required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; ATP synthase complex assembly protein ATP12 574178 2896740 KLLA0_A06259g Kluyveromyces lactis ATP synthase complex assembly protein ATP12 XP_451279.1 573195 R 28985 CDS KLLA0_A06281g 2896454 574472..574813 A 1 NC_006037.1 similar to uniprot|P46988 Saccharomyces cerevisiae YJL179W PFD1 Subunit of heterohexameric prefoldin which binds cytosolic chaperonin and transfers target proteins to it involved in the biogenesis of actin and of alpha- and gamma-tubulin; prefolding complex chaperone subunit 574813 2896454 KLLA0_A06281g Kluyveromyces lactis prefolding complex chaperone subunit XP_451280.1 574472 D 28985 CDS KLLA0_A06303g 2896518 complement(575020..575877) A 1 NC_006037.1 similar to uniprot|P46989 Saccharomyces cerevisiae YJL178C ATG27 Type II membrane protein that binds phosphatidylinositol 3-phosphate required for the cytoplasm-to-vacuole targeting (Cvt) pathway; uncharacterized protein 575877 2896518 KLLA0_A06303g Kluyveromyces lactis uncharacterized protein XP_451281.1 575020 R 28985 CDS KLLA0_A06336g 2896509 join(576887..577195,577605..577850) A 1 NC_006037.1 similar to uniprot|P46990 Saccharomyces cerevisiae RPL17B Protein or YKL180W uniprot|P05740 Saccharomyces cerevisiae YKL180W RPL17A Protein component of the large (60S) ribosomal subunit; 60S ribosomal protein uL22 577850 2896509 KLLA0_A06336g Kluyveromyces lactis 60S ribosomal protein uL22 XP_451283.1 576887 D 28985 CDS KLLA0_A06402g 2896448 complement(578090..580057) A 1 NC_006037.1 similar to uniprot|P34237 Saccharomyces cerevisiae YKL179C; uncharacterized protein 580057 2896448 KLLA0_A06402g Kluyveromyces lactis uncharacterized protein XP_451285.1 578090 R 28985 CDS KLLA0_A06424g 2896729 complement(580397..583288) A 1 NC_006037.1 weakly similar to uniprot|P32591 Saccharomyces cerevisiae YJL176C SWI3 transcription factor; uncharacterized protein 583288 2896729 KLLA0_A06424g Kluyveromyces lactis uncharacterized protein XP_451286.1 580397 R 28985 CDS KLLA0_A06446g 2896344 583793..584659 A 1 NC_006037.1 no similarity; uncharacterized protein 584659 2896344 KLLA0_A06446g Kluyveromyces lactis uncharacterized protein XP_451287.1 583793 D 28985 CDS KLLA0_A06468g 2896567 586957..587778 A 1 NC_006037.1 similar to uniprot|P39005 Saccharomyces cerevisiae YJL174W KRE9 Glycoprotein involved in cell wall beta-glucan assembly null mutation leads to severe growth defects aberrant multibudded morphology and mating defects; uncharacterized protein 587778 2896567 KLLA0_A06468g Kluyveromyces lactis uncharacterized protein XP_451288.1 586957 D 28985 CDS KLLA0_A06490g 2896764 complement(588024..588374) A 1 NC_006037.1 similar to uniprot|P26755 Saccharomyces cerevisiae YJL173C RFA3 Subunit of heterotrimeric Replication Factor A (RF-A) which is a highly conserved single-stranded DNA binding protein involved in DNA replication repair and recombination; uncharacterized protein 588374 2896764 KLLA0_A06490g Kluyveromyces lactis uncharacterized protein XP_451289.2 588024 R 28985 CDS KLLA0_A06512g 2896847 589213..591012 A 1 NC_006037.1 similar to uniprot|P27614 Saccharomyces cerevisiae YJL172W CPS1 Vacuolar carboxypeptidase yscS expression is induced under low-nitrogen conditions; Gly-Xaa carboxypeptidase 591012 2896847 KLLA0_A06512g Kluyveromyces lactis Gly-Xaa carboxypeptidase XP_451290.1 589213 D 28985 CDS KLLA0_A06534g 2896754 complement(591225..592532) A 1 NC_006037.1 similar to uniprot|P06783 Saccharomyces cerevisiae YKL178C STE3 Cell surface a factor receptor transcribed in alpha cells and required for mating by alpha cells couples to MAP kinase cascade to mediate pheromone response ligand bound receptors undergo endocytosis and recycling to the plasma membrane; uncharacterized protein 592532 2896754 KLLA0_A06534g Kluyveromyces lactis uncharacterized protein XP_451291.1 591225 R 28985 CDS KLLA0_A06556g 2896514 complement(593187..594386) A 1 NC_006037.1 similar to uniprot|P46992 Saccharomyces cerevisiae YJL171C; uncharacterized protein 594386 2896514 KLLA0_A06556g Kluyveromyces lactis uncharacterized protein XP_451292.1 593187 R 28985 CDS KLLA0_A06578g 2896856 complement(594872..595564) A 1 NC_006037.1 similar to uniprot|P46993 Saccharomyces cerevisiae YJL170C ASG7 Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell specific to a-cells and induced by alpha-factor; uncharacterized protein 595564 2896856 KLLA0_A06578g Kluyveromyces lactis uncharacterized protein XP_451293.1 594872 R 28985 CDS KLLA0_A06600g 2896759 complement(596010..598118) A 1 NC_006037.1 similar to uniprot|P46995 Saccharomyces cerevisiae YJL168C SET2 Histone methyltransferase with a role in transcriptional elongation methylates a lysine residue of histone H3 associates with the C-terminal domain of Rpo21p histone methylation activity is regulated by phosphorylation status of Rpo21p; histone methyltransferase SET2 598118 2896759 KLLA0_A06600g Kluyveromyces lactis histone methyltransferase SET2 XP_451294.1 596010 R 28985 CDS KLLA0_A06622g 2896770 complement(598561..600705) A 1 NC_006037.1 similar to uniprot|Q757Y7 Ashbya gossypii AEL127C AEL127Cp and weakly similar to YKL176C uniprot|P34239 Saccharomyces cerevisiae YKL176C LST4 Protein possibly involved in a post-Golgi secretory pathway required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface; uncharacterized protein 600705 2896770 KLLA0_A06622g Kluyveromyces lactis uncharacterized protein XP_451295.1 598561 R 28985 CDS KLLA0_A06644g 2896712 601527..602948 A 1 NC_006037.1 similar to uniprot|P34240 Saccharomyces cerevisiae YKL175W ZRT3 Vacuolar membrane zinc transporter transports zinc from storage in the vacuole to the cytoplasm when needed transcription is induced under conditions of zinc deficiency; Zn(2+) transporter ZRT3 602948 2896712 KLLA0_A06644g Kluyveromyces lactis Zn(2+) transporter ZRT3 XP_451296.1 601527 D 28985 CDS KLLA0_A06666g 2896747 complement(603169..604851) A 1 NC_006037.1 similar to uniprot|P36029 Saccharomyces cerevisiae YKL174C TPO5 Protein involved in excretion of putrescine and spermidine putative polyamine transporter in the Golgi or post-Golgi vesicles; uncharacterized protein 604851 2896747 KLLA0_A06666g Kluyveromyces lactis uncharacterized protein XP_451297.1 603169 R 28985 CDS KLLA0_A06688g 2896722 605011..607812 A 1 NC_006037.1 similar to uniprot|P36048 Saccharomyces cerevisiae YKL173W SNU114 involved in splicing U5 snRNP-specific protein related to EF-2; U5 snRNP GTPase SNU114 607812 2896722 KLLA0_A06688g Kluyveromyces lactis U5 snRNP GTPase SNU114 XP_451298.1 605011 D 28985 CDS KLLA0_A06710g 2896697 608103..609374 A 1 NC_006037.1 similar to uniprot|P36049 Saccharomyces cerevisiae YKL172W EBP2 Essential protein required for the maturation of 25S rRNA and 60S ribosomal subunit assembly localizes to the nucleolus; uncharacterized protein 609374 2896697 KLLA0_A06710g Kluyveromyces lactis uncharacterized protein XP_451299.1 608103 D 28985 CDS KLLA0_A06732g 2896751 609710..610759 A 1 NC_006037.1 highly similar to uniprot|P08524 Saccharomyces cerevisiae YJL167w ERG20 farnesyl-pyrophosphate synthetase; bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase 610759 2896751 KLLA0_A06732g Kluyveromyces lactis bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase XP_451300.1 609710 D 28985 CDS KLLA0_A06754g 2896709 611055..611339 A 1 NC_006037.1 highly similar to uniprot|P08525 Saccharomyces cerevisiae YJL166W QCR8 Ubiquinol cytochrome-c reductase subunit 8; ubiquinol--cytochrome-c reductase subunit 8 611339 2896709 KLLA0_A06754g Kluyveromyces lactis ubiquinol--cytochrome-c reductase subunit 8 XP_451301.1 611055 D 28985 CDS KLLA0_A06776g 2896748 612115..614517 A 1 NC_006037.1 similar to uniprot|Q757Y0 Ashbya gossypii AEL120W AEL120Wp and some similarites with YKL171W uniprot|P36003 Saccharomyces cerevisiae YKL171W; protein kinase NNK1 614517 2896748 KLLA0_A06776g Kluyveromyces lactis protein kinase NNK1 XP_451302.1 612115 D 28985 CDS KLLA0_A06798g 2896511 614979..615395 A 1 NC_006037.1 highly similar to uniprot|P35996 Saccharomyces cerevisiae YKL170W MRPL38 Mitochondrial ribosomal protein of the large subunit appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; mitochondrial 54S ribosomal protein uL14m 615395 2896511 KLLA0_A06798g Kluyveromyces lactis mitochondrial 54S ribosomal protein uL14m XP_451303.1 614979 D 28985 CDS KLLA0_A06820g 2896336 complement(615686..618004) A 1 NC_006037.1 weakly similar to uniprot|P38970 Saccharomyces cerevisiae YJL165C HAL5 Putative protein kinase overexpression increases sodium and lithium tolerance whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake suggesting a role in regulation of Trk1p and/or Trk2p transporters; uncharacterized protein 618004 2896336 KLLA0_A06820g Kluyveromyces lactis uncharacterized protein XP_451304.1 615686 R 28985 CDS KLLA0_A06842g 2896482 complement(618848..620818) A 1 NC_006037.1 conserved hypothetical protein; uncharacterized protein 620818 2896482 KLLA0_A06842g Kluyveromyces lactis uncharacterized protein XP_451305.1 618848 R 28985 CDS KLLA0_A06886g 2896520 complement(621646..623409) A 1 NC_006037.1 similar to uniprot|P19145 Saccharomyces cerevisiae YKR039W GAP1 General amino acid permease localization to the plasma membrane is regulated by nitrogen source; uncharacterized protein 623409 2896520 KLLA0_A06886g Kluyveromyces lactis uncharacterized protein XP_451306.1 621646 R 28985 CDS KLLA0_A06930g 2896475 complement(625498..627261) A 1 NC_006037.1 similar to uniprot|P19145 Saccharomyces cerevisiae YKR039W GAP1 General amino acid permease localization to the plasma membrane is regulated by nitrogen source; uncharacterized protein 627261 2896475 KLLA0_A06930g Kluyveromyces lactis uncharacterized protein XP_451307.1 625498 R 28985 CDS KLLA0_A06952g 2896470 complement(628173..630323) A 1 NC_006037.1 similar to uniprot|Q05497 Saccharomyces cerevisiae YDR338C; uncharacterized protein 630323 2896470 KLLA0_A06952g Kluyveromyces lactis uncharacterized protein XP_451308.1 628173 R 28985 CDS KLLA0_A06974g 2896517 complement(630572..631459) A 1 NC_006037.1 similar to uniprot|Q757W2 Ashbya gossypii AEL100W YNG2 Chromatin modification-related protein YNG2 and some similarities with YHR090C uniprot|P38806 Saccharomyces cerevisiae YHR090C YNG2 Yeast homolog of mammalian Ing1 NuA4 histone acetyltransferase complex component; histone acetyltransferase YNG2 631459 2896517 KLLA0_A06974g Kluyveromyces lactis histone acetyltransferase YNG2 XP_451309.1 630572 R 28985 CDS KLLA0_A06996g 2896525 631799..632410 A 1 NC_006037.1 similar to uniprot|Q06170 Saccharomyces cerevisiae YLR326W; uncharacterized protein 632410 2896525 KLLA0_A06996g Kluyveromyces lactis uncharacterized protein XP_451310.1 631799 D 28985 CDS KLLA0_A07018g 2896486 complement(632523..633092) A 1 NC_006037.1 highly similar to uniprot|Q05498 Saccharomyces cerevisiae YDR339C Protein required for cell viability; rRNA-processing protein FCF1 633092 2896486 KLLA0_A07018g Kluyveromyces lactis rRNA-processing protein FCF1 XP_451311.1 632523 R 28985 CDS KLLA0_A07040g 2896527 complement(633503..635452) A 1 NC_006037.1 highly similar to uniprot|Q05506 Saccharomyces cerevisiae YDR341C Cytoplasmic arginyl-tRNA synthetase; arginine--tRNA ligase 635452 2896527 KLLA0_A07040g Kluyveromyces lactis arginine--tRNA ligase XP_451312.1 633503 R 28985 CDS KLLA0_A07051g 9487366 complement(join(635924..636086,636166..636275)) A 1 NC_006037.1 no similarity; uncharacterized protein 636275 9487366 KLLA0_A07051g Kluyveromyces lactis uncharacterized protein XP_002999349.1 635924 R 28985 CDS KLLA0_A07062g 2896749 complement(636546..638291) A 1 NC_006037.1 highly similar to uniprot|P15705 Saccharomyces cerevisiae YOR027W STI1 Heat shock protein also induced by canavanine and entry into stationary phase; Hsp90 cochaperone STI1 638291 2896749 KLLA0_A07062g Kluyveromyces lactis Hsp90 cochaperone STI1 XP_451313.1 636546 R 28985 CDS KLLA0_A07084g 2896814 638900..640483 A 1 NC_006037.1 similar to uniprot|Q07015 Saccharomyces cerevisiae YDR257C SET7 Nuclear protein that contains a SET-domain which have been shown to mediate methyltransferase activity in other proteins; ribosomal lysine N-methyltransferase 640483 2896814 KLLA0_A07084g Kluyveromyces lactis ribosomal lysine N-methyltransferase XP_451314.1 638900 D 28985 CDS KLLA0_A07106g 2896730 complement(640536..641468) A 1 NC_006037.1 similar to uniprot|P26449 Saccharomyces cerevisiae YOR026W BUB3 Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase delays anaphase in the presence of unattached kinetochores forms complexes with Mad1p-Bub1p and with Cdc20p binds Mad2p and Mad3p; uncharacterized protein 641468 2896730 KLLA0_A07106g Kluyveromyces lactis uncharacterized protein XP_451315.1 640536 R 28985 CDS KLLA0_A07128g 2896734 641974..643551 A 1 NC_006037.1 similar to uniprot|Q03370 Saccharomyces cerevisiae YDR479C PEX29 Peroxisomal integral membrane protein involved in regulation of peroxisome size and number genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p Pex31p and Pex32p; uncharacterized protein 643551 2896734 KLLA0_A07128g Kluyveromyces lactis uncharacterized protein XP_451316.1 641974 D 28985 CDS KLLA0_A07150g 2896468 complement(643679..644251) A 1 NC_006037.1 weakly similar to uniprot|P40993 Saccharomyces cerevisiae YDR478W SNM1 Subunit of RNase MRP which cleaves pre-rRNA not shared between Rnase MRP and nuclear Rnase P in contrast to all other Rnase MRP protein subunits binds to the NME1 RNA subunit of Rnase MRP; uncharacterized protein 644251 2896468 KLLA0_A07150g Kluyveromyces lactis uncharacterized protein XP_451317.1 643679 R 28985 CDS KLLA0_A07172g 2896529 complement(644634..646013) A 1 NC_006037.1 similar to uniprot|P53687 Saccharomyces cerevisiae YOR025W HST3 Member of the Sir2 family of NAD()-dependent protein deacetylases involved along with Hst4p in telomeric silencing cell cycle progression radiation resistance genomic stability and short-chain fatty acid metabolism; NAD-dependent histone deacetylase HST3 646013 2896529 KLLA0_A07172g Kluyveromyces lactis NAD-dependent histone deacetylase HST3 XP_451318.1 644634 R 28985 CDS KLLA0_A07194g 2896327 complement(join(646573..646987,647529..647548)) A 1 NC_006037.1 highly similar to uniprot|P07280 Saccharomyces cerevisiae YOL121C RPS19A Protein component of the small (40S) ribosomal subunit or YNL302C uniprot|P07281 Saccharomyces cerevisiae YNL302C RPS19B Protein component of the small (40S) ribosomal subunit; 40S ribosomal protein eS19 647548 2896327 KLLA0_A07194g Kluyveromyces lactis 40S ribosomal protein eS19 XP_451319.1 646573 R 28985 CDS KLLA0_A07227g 2896337 complement(join(648431..648879,649377..649488)) A 1 NC_006037.1 highly similar to uniprot|P07279 Saccharomyces cerevisiae YOL120C RPL18A Protein component of the large (60S) ribosomal subunit, identical to Rpl18Bp and has similarity to rat L18 ribosomal protein; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; 60S ribosomal protein eL18 649488 2896337 KLLA0_A07227g Kluyveromyces lactis 60S ribosomal protein eL18 XP_451321.1 648431 R 28985 CDS KLLA0_A07249g 2896332 complement(649905..651431) A 1 NC_006037.1 similar to uniprot|Q08268 Saccharomyces cerevisiae YOL119C MCH4 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport; uncharacterized protein 651431 2896332 KLLA0_A07249g Kluyveromyces lactis uncharacterized protein XP_451322.1 649905 R 28985 CDS KLLA0_A07271g 2896391 complement(651863..652408) A 1 NC_006037.1 highly similar to uniprot|Q75AS4 Ashbya gossypii ADL154C ADL154Cp and some similarities with uniprot|P38013 Saccharomyces cerevisiae YLR109w AHP1 Alkyl hydroperoxide reductase; uncharacterized protein 652408 2896391 KLLA0_A07271g Kluyveromyces lactis uncharacterized protein XP_451323.1 651863 R 28985 CDS KLLA0_A07293g 2896316 652702..654453 A 1 NC_006037.1 weakly similar to uniprot|Q12348 Saccharomyces cerevisiae YOL117W RRI2 subunit of COP9 Signalosome (CSN) like protein complex that cleaves the ubiquitin-like protein Rub1 from Cdc53 COP9 signalosome (CSN) subunit; uncharacterized protein 654453 2896316 KLLA0_A07293g Kluyveromyces lactis uncharacterized protein XP_451324.1 652702 D 28985 CDS KLLA0_A07315g 2896439 655210..655533 A 1 NC_006037.1 similar to uniprot|P48560 Saccharomyces cerevisiae YNL300W; uncharacterized protein 655533 2896439 KLLA0_A07315g Kluyveromyces lactis uncharacterized protein XP_451325.1 655210 D 28985 CDS KLLA0_A07337g 2896719 656187..657368 A 1 NC_006037.1 similar to uniprot|P22148 Saccharomyces cerevisiae YOL116W MSN1 Transcriptional activator involved in regulation of invertase and glucoamylase expression invasive growth and pseudohyphal differentiation iron uptake chromium accumulation and response to osmotic stress localizes to the nucleus; uncharacterized protein 657368 2896719 KLLA0_A07337g Kluyveromyces lactis uncharacterized protein XP_451326.1 656187 D 28985 CDS KLLA0_A07359g 2896745 657936..659990 A 1 NC_006037.1 similar to uniprot|P53632 Saccharomyces cerevisiae YOL115W TRF4 DNA polymerase sigma involved in mitotic chromsome condensation; uncharacterized protein 659990 2896745 KLLA0_A07359g Kluyveromyces lactis uncharacterized protein XP_451327.1 657936 D 28985 CDS KLLA0_A07381g 2896523 complement(660082..660579) A 1 NC_006037.1 similar to gnl|GLV|CAGL0E02123g Candida glabrata CAGL0E02123g and weakly similar to YOL114C uniprot|Q12322 Saccharomyces cerevisiae YOL114C; uncharacterized protein 660579 2896523 KLLA0_A07381g Kluyveromyces lactis uncharacterized protein XP_451328.1 660082 R 28985 CDS KLLA0_A07403g 2896420 661261..663900 A 1 NC_006037.1 similar to uniprot|P48562 Saccharomyces cerevisiae YNL298W CLA4 Involved in localizing cell growth with respect to the septin ring protein kinase homologous to Ste20p interacts with CDC42; uncharacterized protein 663900 2896420 KLLA0_A07403g Kluyveromyces lactis uncharacterized protein XP_451329.1 661261 D 28985 CDS KLLA0_A07425g 2896441 complement(663956..668764) A 1 NC_006037.1 similar to uniprot|P48563 Saccharomyces cerevisiae YNL297C MON2 Peripheral membrane protein with a role in endocytosis and vacuole integrity interacts with Arl1p and localizes to the endosome member of the Sec7p family of proteins; uncharacterized protein 668764 2896441 KLLA0_A07425g Kluyveromyces lactis uncharacterized protein XP_451330.1 663956 R 28985 CDS KLLA0_A07447g 2896425 669272..670732 A 1 NC_006037.1 similar to uniprot|P48564 Saccharomyces cerevisiae YNL295W; uncharacterized protein 670732 2896425 KLLA0_A07447g Kluyveromyces lactis uncharacterized protein XP_451331.1 669272 D 28985 CDS KLLA0_A07469g 2896424 complement(670942..672501) A 1 NC_006037.1 similar to uniprot|Q758G4 Ashbya gossypii AEL202C RIM21 pH-response regulator protein palH/RIM21 and weakly similar to YNL294C uniprot|P48565 Saccharomyces cerevisiae YNL294C RIM21 Protein proposed to be involved in the response to alkaline pH; has similarity to A. nidulans PalH; uncharacterized protein 672501 2896424 KLLA0_A07469g Kluyveromyces lactis uncharacterized protein XP_451332.1 670942 R 28985 CDS KLLA0_A07491g 2896434 673198..675057 A 1 NC_006037.1 similar to uniprot|P48566 Saccharomyces cerevisiae YNL293W; Rab GTPase-activating protein MSB3 675057 2896434 KLLA0_A07491g Kluyveromyces lactis Rab GTPase-activating protein MSB3 XP_451333.1 673198 D 28985 CDS KLLA0_A07513g 2896563 complement(675169..675804) A 1 NC_006037.1 similar to uniprot|Q12285 Saccharomyces cerevisiae YOL111C; uncharacterized protein 675804 2896563 KLLA0_A07513g Kluyveromyces lactis uncharacterized protein XP_451334.1 675169 R 28985 CDS KLLA0_A07535g 2896443 676032..676808 A 1 NC_006037.1 similar to uniprot|P41912 Saccharomyces cerevisiae YOL110W SHR5 Subunit of a palmitoyltransferase composed of Shr5p and Erf2p that adds a palmitoyl lipid moiety to Ras2p through a thioester linkage palmitoylation is required for Ras2p localization to the plasma membrane; uncharacterized protein 676808 2896443 KLLA0_A07535g Kluyveromyces lactis uncharacterized protein XP_451335.1 676032 D 28985 CDS KLLA0_A07557g 2896373 677067..679394 A 1 NC_006037.1 some similarities with uniprot|P36165 YKR089C Saccharomyces cerevisiae STC1 Protein of unknown function found in lipid particles potential Cdc28p substrate; triacylglycerol lipase 679394 2896373 KLLA0_A07557g Kluyveromyces lactis triacylglycerol lipase XP_451336.1 677067 D 28985 CDS KLLA0_A07579g 2896323 complement(679469..681631) A 1 NC_006037.1 weakly similar to uniprot|Q7LGN4 Saccharomyces cerevisiae YOR080W DIA2 Protein of unknown function involved in invasive and pseudohyphal growth; DNA-binding SCF ubiquitin ligase subunit DIA2 681631 2896323 KLLA0_A07579g Kluyveromyces lactis DNA-binding SCF ubiquitin ligase subunit DIA2 XP_451337.1 679469 R 28985 CDS KLLA0_A07601g 2896432 682057..683001 A 1 NC_006037.1 weakly similar to uniprot|Q12067 Saccharomyces cerevisiae YOR079C ATX2 Golgi membrane protein involved in manganese homeostasis overproduction suppresses the sod1 (copper zinc superoxide dismutase) null mutation; Mn(2+) transporter ATX2 683001 2896432 KLLA0_A07601g Kluyveromyces lactis Mn(2+) transporter ATX2 XP_451338.1 682057 D 28985 CDS KLLA0_A07623g 2896405 complement(683112..683864) A 1 NC_006037.1 some similarities with uniprot|O00033 Saccharomyces cerevisiae YOR078W BUD21 Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA originally isolated as bud-site selection mutant that displays a random budding pattern; uncharacterized protein 683864 2896405 KLLA0_A07623g Kluyveromyces lactis uncharacterized protein XP_451339.1 683112 R 28985 CDS KLLA0_A07645g 2896367 complement(684223..685041) A 1 NC_006037.1 conserved hypothetical protein; uncharacterized protein 685041 2896367 KLLA0_A07645g Kluyveromyces lactis uncharacterized protein XP_451340.1 684223 R 28985 CDS KLLA0_A07667g 2896436 685696..686613 A 1 NC_006037.1 similar to uniprot|P36164 Saccharomyces cerevisiae YKR088C TVP38 Integral membrane protein localized to vesicles along with the v-SNARE Tlg2p green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; uncharacterized protein 686613 2896436 KLLA0_A07667g Kluyveromyces lactis uncharacterized protein XP_451341.1 685696 D 28985 CDS KLLA0_A07689g 2896369 complement(686738..687457) A 1 NC_006037.1 similar to uniprot|P40962 Saccharomyces cerevisiae YOR077W YORO77W; uncharacterized protein 687457 2896369 KLLA0_A07689g Kluyveromyces lactis uncharacterized protein XP_451342.1 686738 R 28985 CDS KLLA0_A07711g 2896364 687735..688772 A 1 NC_006037.1 highly similar to uniprot|P36163 Saccharomyces cerevisiae YKR087C OMA1 Metalloendopeptidase of the mitochondrial inner membrane involved in turnover of membrane-embedded proteins member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes; metalloendopeptidase 688772 2896364 KLLA0_A07711g Kluyveromyces lactis metalloendopeptidase XP_451343.1 687735 D 28985 CDS KLLA0_A07733g 2896699 complement(688856..692050) A 1 NC_006037.1 similar to uniprot|P15938 Saccharomyces cerevisiae YKR086W PRP16 RNA helicase in the DEAH-box family involved in the second catalytic step of splicing exhibits ATP-dependent RNA unwinding activity; DEAH-box RNA helicase PRP16 692050 2896699 KLLA0_A07733g Kluyveromyces lactis DEAH-box RNA helicase PRP16 XP_451344.1 688856 R 28985 CDS KLLA0_A07755g 2896698 692606..693199 A 1 NC_006037.1 similar to uniprot|P22354 Saccharomyces cerevisiae YKR085C MRPL20 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein mL58 693199 2896698 KLLA0_A07755g Kluyveromyces lactis mitochondrial 54S ribosomal protein mL58 XP_451345.1 692606 D 28985 CDS KLLA0_A07777g 2896430 complement(693423..693911) A 1 NC_006037.1 conserved hypothetical protein; uncharacterized protein 693911 2896430 KLLA0_A07777g Kluyveromyces lactis uncharacterized protein XP_451346.1 693423 R 28985 CDS KLLA0_A07799g 2896427 join(694308..694563,694879..697112) A 1 NC_006037.1 similar to uniprot|P32769 Saccharomyces cerevisiae YKR084C; ribosome dissociation factor GTPase HBS1 697112 2896427 KLLA0_A07799g Kluyveromyces lactis ribosome dissociation factor GTPase HBS1 XP_451347.2 694308 D 28985 CDS KLLA0_A07821g 2896767 complement(697189..698178) A 1 NC_006037.1 similar to uniprot|P41834 Saccharomyces cerevisiae YOR075W UFE1 t-SNARE that resides on the endoplasmic reticulum and mediates retrograde traffic from the Golgi complex potential Cdc28p substrate endoplasmic reticulum t-SNARE coprecipitates with Sec20p Tip1p. and Sec22p; uncharacterized protein 698178 2896767 KLLA0_A07821g Kluyveromyces lactis uncharacterized protein XP_451348.1 697189 R 28985 CDS KLLA0_A07843g 2896417 698626..699564 A 1 NC_006037.1 highly similar to uniprot|P06785 Saccharomyces cerevisiae YOR074C CDC21 Thymidylate synthase required for de novo biosynthesis of pyrimidine deoxyribonucleotides expression is induced at G1/S; thymidylate synthase 699564 2896417 KLLA0_A07843g Kluyveromyces lactis thymidylate synthase XP_451349.1 698626 D 28985 CDS KLLA0_A07865g 2896704 complement(699725..701509) A 1 NC_006037.1 weakly similar to uniprot|O00031 Saccharomyces cerevisiae YOR073W SGO1 Component of the spindle checkpoint involved in sensing lack of tension on mitotic chromosomes protects centromeric Rec8p at meiosis I required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability; uncharacterized protein 701509 2896704 KLLA0_A07865g Kluyveromyces lactis uncharacterized protein XP_451350.1 699725 R 28985 CDS KLLA0_A07887g 2896437 702046..702444 A 1 NC_006037.1 similar to uniprot|Q759Q6 Ashbya gossypii ADR217C DAD2 DASH complex subunit DAD2 and weakly similar to YKR083C uniprot|P36162 Saccharomyces cerevisiae YKR083C DAD2 Essential protein component of the DASH complex involved in spindle integrity and kinetochore function interacts with Duo1p and Dam1p localizes to intranuclear spindles and kinetochore; uncharacterized protein 702444 2896437 KLLA0_A07887g Kluyveromyces lactis uncharacterized protein XP_451351.1 702046 D 28985 CDS KLLA0_A07909g 2896760 complement(702533..705853) A 1 NC_006037.1 similar to uniprot|P36161 Saccharomyces cerevisiae YKR082W NUP133 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) localizes to both sides of the NPC required to establish a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; uncharacterized protein 705853 2896760 KLLA0_A07909g Kluyveromyces lactis uncharacterized protein XP_451352.1 702533 R 28985 CDS KLLA0_A07931g 2896311 706289..707323 A 1 NC_006037.1 highly similar to uniprot|P36160 Saccharomyces cerevisiae YKR081C RPF2; rRNA-binding ribosome biosynthesis protein RPF2 707323 2896311 KLLA0_A07931g Kluyveromyces lactis rRNA-binding ribosome biosynthesis protein RPF2 XP_451353.1 706289 D 28985 CDS KLLA0_A07953g 2896481 complement(707461..708441) A 1 NC_006037.1 highly similar to uniprot|Q02046 Saccharomyces cerevisiae YKR080W MTD1 NAD-dependent 5 10-methylenetetrahydrafolate dehydrogenase plays a catalytic role in oxidation of cytoplasmic one-carbon units expression is regulated by Bas1p and Bas2p repressed by adenine and may be induced by inositol and choline; methylenetetrahydrofolate dehydrogenase (NAD(+)) 708441 2896481 KLLA0_A07953g Kluyveromyces lactis methylenetetrahydrofolate dehydrogenase (NAD(+)) XP_451354.1 707461 R 28985 CDS KLLA0_A07975g 2896307 709271..710911 A 1 NC_006037.1 similar to uniprot|Q08484 Saccharomyces cerevisiae YOR070C GYP1 Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p Sec4p Ypt7p and Ypt51p (in vitro) involved in vesicle docking and fusion; GTPase-activating protein GYP1 710911 2896307 KLLA0_A07975g Kluyveromyces lactis GTPase-activating protein GYP1 XP_451355.1 709271 D 28985 CDS KLLA0_A07997g 2896780 711231..712958 A 1 NC_006037.1 similar to uniprot|P06779 Saccharomyces cerevisiae YJR052W RAD7 Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair subunit of Nucleotide Excision Repair Factor 4 (NEF4); UV-damaged DNA-binding protein RAD7 712958 2896780 KLLA0_A07997g Kluyveromyces lactis UV-damaged DNA-binding protein RAD7 XP_451356.1 711231 D 28985 CDS KLLA0_A08019g 2896694 complement(713019..714866) A 1 NC_006037.1 similar to uniprot|P39682 Saccharomyces cerevisiae YML046W PRP39 U1 snRNP protein involved in splicing contains multiple tetriatricopeptide repeats; uncharacterized protein 714866 2896694 KLLA0_A08019g Kluyveromyces lactis uncharacterized protein XP_451357.1 713019 R 28985 CDS KLLA0_A08041g 2896773 715347..717176 A 1 NC_006037.1 some similarities with uniprot|P47113 Saccharomyces cerevisiae YJR053W BFA1 Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis; uncharacterized protein 717176 2896773 KLLA0_A08041g Kluyveromyces lactis uncharacterized protein XP_451358.1 715347 D 28985 CDS KLLA0_A08063g 2896363 717703..719253 A 1 NC_006037.1 some similarities with uniprot|P47114 Saccharomyces cerevisiae YJR054W Vacuolar protein of unknown function potential Cdc28p substrate; pheromone-regulated K(+) transporter PRM6 719253 2896363 KLLA0_A08063g Kluyveromyces lactis pheromone-regulated K(+) transporter PRM6 XP_451359.1 717703 D 28985 CDS KLLA0_A08107g 2896378 complement(719825..720982) A 1 NC_006037.1 similar to uniprot|Q04697 Saccharomyces cerevisiae YML048W GSF2 ER localized integral membrane protein that may promote secretion of certain hexose transporters including Gal2p involved in glucose-dependent repression; uncharacterized protein 720982 2896378 KLLA0_A08107g Kluyveromyces lactis uncharacterized protein XP_451360.1 719825 R 28985 CDS KLLA0_A08129g 2896375 722217..726026 A 1 NC_006037.1 similar to uniprot|Q04693 Saccharomyces cerevisiae YML049C RSE1 RNA splicing and ER to Golgi transport involved in secretion and RNA splicing; U2 snRNP complex subunit RSE1 726026 2896375 KLLA0_A08129g Kluyveromyces lactis U2 snRNP complex subunit RSE1 XP_451361.1 722217 D 28985 CDS KLLA0_A08140g 2896388 complement(726017..726985) A 1 NC_006037.1 similar to uniprot|Q04689 Saccharomyces cerevisiae YML050W; uncharacterized protein 726985 2896388 KLLA0_A08140g Kluyveromyces lactis uncharacterized protein XP_451362.1 726017 R 28985 CDS KLLA0_A08162g 2896324 complement(727416..728789) A 1 NC_006037.1 uniprot|Q06433 Kluyveromyces lactis KLLA0A08162g GAL80 Galactose/lactose metabolism regulatory protein GAL80; transcription regulator GAL80 728789 2896324 KLLA0_A08162g Kluyveromyces lactis transcription regulator GAL80 XP_451363.1 727416 R 28985 CDS KLLA0_A08184g 2896401 complement(729440..730312) A 1 NC_006037.1 similar to uniprot|P54003 Saccharomyces cerevisiae YML052W SUR7 Multicopy suppressor of rvs167 mutation putative integral membrane protein; uncharacterized protein 730312 2896401 KLLA0_A08184g Kluyveromyces lactis uncharacterized protein XP_451364.1 729440 R 28985 CDS KLLA0_A08206g 2896411 730940..731632 A 1 NC_006037.1 some similarities with uniprot|P53907 Saccharomyces cerevisiae YNL144C; uncharacterized protein 731632 2896411 KLLA0_A08206g Kluyveromyces lactis uncharacterized protein XP_451365.1 730940 D 28985 CDS KLLA0_A08316g 2896736 733200..735302 A 1 NC_006037.1 similar to uniprot|P32340 Saccharomyces cerevisiae YML120C NDI1 NADH:ubiquinone oxidoreductase transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons in contrast to the higher eukaryotic multisubunit respiratory complex I which is absent in S. cerevisiae; uncharacterized protein 735302 2896736 KLLA0_A08316g Kluyveromyces lactis uncharacterized protein XP_451367.1 733200 D 28985 CDS KLLA0_A08338g 2896782 736461..738761 A 1 NC_006037.1 similar to uniprot|P39684 Saccharomyces cerevisiae or to YHR015W uniprot|P38760 Saccharomyces cerevisiae; uncharacterized protein 738761 2896782 KLLA0_A08338g Kluyveromyces lactis uncharacterized protein XP_451368.1 736461 D 28985 CDS KLLA0_A08360g 2896733 complement(join(739092..740316,740718..740764)) A 1 NC_006037.1 similar to Saccharomyces cerevisiae YFR024C-A LSB3 or to YHR016C uniprot|P32793 Saccharomyces cerevisiae YHR016C YSC84; uncharacterized protein 740764 2896733 KLLA0_A08360g Kluyveromyces lactis uncharacterized protein XP_451369.1 739092 R 28985 CDS KLLA0_A08382g 2896718 741712..742857 A 1 NC_006037.1 similar to uniprot|Q757L8 Ashbya gossypii AEL018C AEL018Cp and similar to uniprot|P32792 Saccharomyces cerevisiae YHR017W; uncharacterized protein 742857 2896718 KLLA0_A08382g Kluyveromyces lactis uncharacterized protein XP_451370.1 741712 D 28985 CDS KLLA0_A08404g 2896396 complement(743192..744577) A 1 NC_006037.1 highly similar to uniprot|P04076 Saccharomyces cerevisiae YHR018C ARG4 Argininosuccinate lyase catalyzes the final step in the arginine biosynthesis pathway; argininosuccinate lyase ARG4 744577 2896396 KLLA0_A08404g Kluyveromyces lactis argininosuccinate lyase ARG4 XP_451371.1 743192 R 28985 CDS KLLA0_A08426g 2896402 complement(745048..746712) A 1 NC_006037.1 highly similar to uniprot|P38707 Saccharomyces cerevisiae YHR019C DED81 Cytosolic asparaginyl-tRNA synthetase required for protein synthesis catalyzes the specific attachment of asparagine to its cognate tRNA; asparagine--tRNA ligase DED81 746712 2896402 KLLA0_A08426g Kluyveromyces lactis asparagine--tRNA ligase DED81 XP_451372.1 745048 R 28985 CDS KLLA0_A08448g 2896380 747134..749152 A 1 NC_006037.1 highly similar to uniprot|P38708 Saccharomyces cerevisiae YHR020W Protein required for cell viability; proline--tRNA ligase 749152 2896380 KLLA0_A08448g Kluyveromyces lactis proline--tRNA ligase XP_451373.1 747134 D 28985 CDS KLLA0_A08470g 2896845 complement(749442..750446) A 1 NC_006037.1 similar to uniprot|P38635 Saccharomyces cerevisiae YFR025C HIS2 Histidinolphosphatase catalyzes the eighth step in histidine biosynthesis mutations cause histidine auxotrophy and sensitivity to Cu Co and Ni salts transcription is regulated by general amino acid control; histidinol-phosphatase 750446 2896845 KLLA0_A08470g Kluyveromyces lactis histidinol-phosphatase XP_451374.1 749442 R 28985 CDS KLLA0_A08492g 2896313 751047..752168 A 1 NC_006037.1 conserved hypothetical protein; uncharacterized protein 752168 2896313 KLLA0_A08492g Kluyveromyces lactis uncharacterized protein XP_451375.1 751047 D 28985 CDS KLLA0_A08536g 2896716 753262..754161 A 1 NC_006037.1 some similarities with uniprot|P25587 Saccharomyces cerevisiae YCL005W; uncharacterized protein 754161 2896716 KLLA0_A08536g Kluyveromyces lactis uncharacterized protein XP_451376.1 753262 D 28985 CDS KLLA0_A08580g 2896309 754857..756479 A 1 NC_006037.1 uniprot|Q874C6 Kluyveromyces lactis PGS1 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 756479 2896309 KLLA0_A08580g Kluyveromyces lactis CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase XP_451377.1 754857 D 28985 CDS KLLA0_A08602g 2896755 complement(join(756584..757326,757472..757493)) A 1 NC_006037.1 similar to uniprot|P25565 Saccharomyces cerevisiae YCL002C; uncharacterized protein 757493 2896755 KLLA0_A08602g Kluyveromyces lactis uncharacterized protein XP_451378.2 756584 R 28985 CDS KLLA0_A08624g 2896414 758042..758590 A 1 NC_006037.1 highly similar to uniprot|Q75ET0 Ashbya gossypii AAL002W AAL002Wp and similar to YCL001W uniprot|P25560 Saccharomyces cerevisiae YCL001W RER1 Protein involved in retention of membrane proteins including Sec12p in the ER localized to Golgi functions as a retrieval receptor in returning membrane proteins to the ER; protein retrieval receptor 758590 2896414 KLLA0_A08624g Kluyveromyces lactis protein retrieval receptor XP_451379.1 758042 D 28985 CDS KLLA0_A08646g 2896423 758933..760099 A 1 NC_006037.1 highly similar to uniprot|Q75ES9 Ashbya gossypii AAL001W AAL001Wp and similar to YNL001W uniprot|P33309 Saccharomyces cerevisiae YNL001W DOM34 Probable RNA-binding protein functions in protein translation to promote G1 progression and differentiation required for meiotic cell division; uncharacterized protein 760099 2896423 KLLA0_A08646g Kluyveromyces lactis uncharacterized protein XP_451380.1 758933 D 28985 CDS KLLA0_A08690g 2896731 complement(761149..762084) A 1 NC_006037.1 no similarity; uncharacterized protein 762084 2896731 KLLA0_A08690g Kluyveromyces lactis uncharacterized protein XP_451381.1 761149 R 28985 CDS KLLA0_A08712g 2896811 complement(762700..763440) A 1 NC_006037.1 highly similar to uniprot|P53200 Saccharomyces cerevisiae YGR001C Protein with similarity to methyltransferase family members; required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; protein-lysine N-methyltransferase 763440 2896811 KLLA0_A08712g Kluyveromyces lactis protein-lysine N-methyltransferase XP_451382.1 762700 R 28985 CDS KLLA0_A08734g 2896340 763946..767434 A 1 NC_006037.1 similar to uniprot|P34111 Saccharomyces cerevisiae YAL001C TFC3 Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding; transcription factor TFIIIC subunit TFC3 767434 2896340 KLLA0_A08734g Kluyveromyces lactis transcription factor TFIIIC subunit TFC3 XP_451383.1 763946 D 28985 CDS KLLA0_A08756g 2896407 join(767756..767845,768005..769534) A 1 NC_006037.1 similar to uniprot|P39705 Saccharomyces cerevisiae YAR002W NUP60 Subunit of the nuclear pore complex (NPC) functions to anchor Nup2p to the NPC in a dynamic process that is controlled by the nucleoplasmic concentration of Gsp1p-GTP potential Cdc28p substrate; FG-nucleoporin NUP60 769534 2896407 KLLA0_A08756g Kluyveromyces lactis FG-nucleoporin NUP60 XP_451384.2 767756 D 28985 CDS KLLA0_A08778g 2896737 complement(769697..770350) A 1 NC_006037.1 similar to uniprot|Q05359 Saccharomyces cerevisiae YAR002C-A ERP1 Protein that forms a heterotrimeric complex with Erp2p Emp24p and Erv25p member along with Emp24p and Erv25p of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles; uncharacterized protein 770350 2896737 KLLA0_A08778g Kluyveromyces lactis uncharacterized protein XP_451385.1 769697 R 28985 CDS KLLA0_A08800g 2896487 770989..772308 A 1 NC_006037.1 similar to uniprot|P39706 Saccharomyces cerevisiae YAR003W SWD1 Subunit of the COMPASS complex which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; COMPASS subunit protein SWD1 772308 2896487 KLLA0_A08800g Kluyveromyces lactis COMPASS subunit protein SWD1 XP_451386.1 770989 D 28985 CDS KLLA0_A08822g 2896500 772565..774313 A 1 NC_006037.1 similar to uniprot|P53197 Saccharomyces cerevisiae YGL003C CDH1 CDC20 homolog 1 protein required for Clb2 and Ase1 degradation; uncharacterized protein 774313 2896500 KLLA0_A08822g Kluyveromyces lactis uncharacterized protein XP_451387.1 772565 D 28985 CDS KLLA0_A08844g 2896480 complement(774642..776507) A 1 NC_006037.1 similar to uniprot|P22336 Saccharomyces cerevisiae YAR007C RFA1 Subunit of heterotrimeric Replication Factor A (RF-A) which is a highly conserved single-stranded DNA binding protein involved in DNA replication repair and recombination; replication factor A subunit protein RFA1 776507 2896480 KLLA0_A08844g Kluyveromyces lactis replication factor A subunit protein RFA1 XP_451388.1 774642 R 28985 CDS KLLA0_A08866g 2896499 776960..778231 A 1 NC_006037.1 similar to uniprot|P53196 Saccharomyces cerevisiae YGL004C RPN14 Putative non-ATPase subunit of the 19S regulatory particle of the 26S proteasome localized to the cytoplasm; uncharacterized protein 778231 2896499 KLLA0_A08866g Kluyveromyces lactis uncharacterized protein XP_451389.1 776960 D 28985 CDS KLLA0_A08888g 2896498 778534..779286 A 1 NC_006037.1 similar to uniprot|P53195 Saccharomyces cerevisiae YGL005C COG7 Component of the conserved oligomeric Golgi complex; Golgi transport complex subunit COG7 779286 2896498 KLLA0_A08888g Kluyveromyces lactis Golgi transport complex subunit COG7 XP_451390.1 778534 D 28985 CDS KLLA0_A08910g 2896403 complement(779526..783368) A 1 NC_006037.1 similar to uniprot|P38929 Saccharomyces cerevisiae YGL006W PMC1 May be involved in depleting cytosol of Ca2 ions putative vacuolar Ca2 ATPase; calcium-transporting ATPase PMC1 783368 2896403 KLLA0_A08910g Kluyveromyces lactis calcium-transporting ATPase PMC1 XP_451391.1 779526 R 28985 CDS KLLA0_A08932g 2896707 784599..785492 A 1 NC_006037.1 similar to uniprot|P39707 Saccharomyces cerevisiae YAR008W; tRNA splicing endonuclease subunit SEN34 785492 2896707 KLLA0_A08932g Kluyveromyces lactis tRNA splicing endonuclease subunit SEN34 XP_451392.1 784599 D 28985 CDS KLLA0_A09031g 2896449 787768..790467 A 1 NC_006037.1 highly similar to uniprot|P05030 Saccharomyces cerevisiae YGL008C PMA1 Plasma membrane H -ATPase pumps protons out of the cell major regulator of cytoplasmic pH part of the P2 subgroup of cation-transporting ATPases; H(+)-exporting P2-type ATPase PMA1 790467 2896449 KLLA0_A09031g Kluyveromyces lactis H(+)-exporting P2-type ATPase PMA1 XP_451395.1 787768 D 28985 CDS KLLA0_A09075g 2896828 complement(792171..793367) A 1 NC_006037.1 uniprot|P40952 Kluyveromyces lactis KLLA0A09075g KYE1 NADPH dehydrogenase 1; NADPH dehydrogenase 793367 2896828 KLLA0_A09075g Kluyveromyces lactis NADPH dehydrogenase XP_451397.1 792171 R 28985 CDS KLLA0_A09097g 2896735 794827..797244 A 1 NC_006037.1 similar to uniprot|Q750N6 Ashbya gossypii AGL086C AGL086Cp and some similarites with YGL014W uniprot|P25339 Saccharomyces cerevisiae YGL014W PUF4 member of the PUF protein family YGL014W; uncharacterized protein 797244 2896735 KLLA0_A09097g Kluyveromyces lactis uncharacterized protein XP_451398.1 794827 D 28985 CDS KLLA0_A09119g 2896723 complement(797533..800781) A 1 NC_006037.1 weakly similar to uniprot|P12383 Saccharomyces cerevisiae YGL013C PDR1 Zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; drug-responsive transcription factor PDR1 800781 2896723 KLLA0_A09119g Kluyveromyces lactis drug-responsive transcription factor PDR1 XP_451399.1 797533 R 28985 CDS KLLA0_A09141g 2896513 801373..803655 A 1 NC_006037.1 weakly similar to uniprot|P38863 YHR172W Saccharomyces cerevisiae SPC97 Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; uncharacterized protein 803655 2896513 KLLA0_A09141g Kluyveromyces lactis uncharacterized protein XP_451400.1 801373 D 28985 CDS KLLA0_A09185g 2896838 804448..805761 A 1 NC_006037.1 highly similar to uniprot|P00924 Saccharomyces cerevisiae YGR254W ENO1 Enolase I and to uniprot|P00925 Saccharomyces cerevisiae YHR174W ENO2 Enolase II; uncharacterized protein 805761 2896838 KLLA0_A09185g Kluyveromyces lactis uncharacterized protein XP_451402.1 804448 D 28985 CDS KLLA0_A09207g 2896664 806124..806531 A 1 NC_006037.1 some similarities with uniprot|P38865 Saccharomyces cerevisiae YHR175W CTR2; low-affinity Cu transporter 806531 2896664 KLLA0_A09207g Kluyveromyces lactis low-affinity Cu transporter XP_451403.1 806124 D 28985 CDS KLLA0_A09229g 2896516 806734..808005 A 1 NC_006037.1 similar to uniprot|P38866 Saccharomyces cerevisiae YHR176W FMO1 Flavin-containing monooxygenase localized to the cytoplasmic face of the ER membrane catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins; N,N-dimethylaniline monooxygenase 808005 2896516 KLLA0_A09229g Kluyveromyces lactis N,N-dimethylaniline monooxygenase XP_451404.1 806734 D 28985 CDS KLLA0_A09251g 2896510 808253..810319 A 1 NC_006037.1 similar to uniprot|P38699 Saccharomyces cerevisiae YHR178W STB5 binds Sin3p in two-hybrid assay Zinc finger (6-Cys); uncharacterized protein 810319 2896510 KLLA0_A09251g Kluyveromyces lactis uncharacterized protein XP_451405.1 808253 D 28985 CDS KLLA0_A09295g 2896505 810967..811647 A 1 NC_006037.1 similar to uniprot|P38869 Saccharomyces cerevisiae YHR181W SVP26 Component of Sed5p vesicles; uncharacterized protein 811647 2896505 KLLA0_A09295g Kluyveromyces lactis uncharacterized protein XP_451406.1 810967 D 28985 CDS KLLA0_A09317g 2896461 811860..813809 A 1 NC_006037.1 weakly similar to uniprot|P38870 Saccharomyces cerevisiae YHR182W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; uncharacterized protein 813809 2896461 KLLA0_A09317g Kluyveromyces lactis uncharacterized protein XP_451407.1 811860 D 28985 CDS KLLA0_A09339g 2896460 814960..816438 A 1 NC_006037.1 highly similar to uniprot|P53319 Saccharomyces cerevisiae YGR256W GND2 and to uniprot|P38720 Saccharomyces cerevisiae YHR183W GND1 6-phosphogluconate dehydrogenase(decarboxylating); phosphogluconate dehydrogenase (decarboxylating) GND1 816438 2896460 KLLA0_A09339g Kluyveromyces lactis phosphogluconate dehydrogenase (decarboxylating) GND1 XP_451408.1 814960 D 28985 CDS KLLA0_A09361g 2896457 816911..818611 A 1 NC_006037.1 weakly similar to uniprot|P38871 Saccharomyces cerevisiae YHR184W SSP1 Protein involved in the control of meiotic nuclear division and spore formation; uncharacterized protein 818611 2896457 KLLA0_A09361g Kluyveromyces lactis uncharacterized protein XP_451409.1 816911 D 28985 CDS KLLA0_A09383g 2896456 complement(818752..819852) A 1 NC_006037.1 similar to uniprot|P53320 Saccharomyces cerevisiae YGR257C MTM1 Mitochondrial protein of the mitochondrial carrier family involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor; uncharacterized protein 819852 2896456 KLLA0_A09383g Kluyveromyces lactis uncharacterized protein XP_451410.1 818752 R 28985 CDS KLLA0_A09405g 2896479 complement(820161..820970) A 1 NC_006037.1 some similarities with uniprot|P38872 Saccharomyces cerevisiae YHR185C PFS1 Sporulation protein; uncharacterized protein 820970 2896479 KLLA0_A09405g Kluyveromyces lactis uncharacterized protein XP_451411.1 820161 R 28985 CDS KLLA0_A09427g 2896490 complement(821244..824279) A 1 NC_006037.1 similar to uniprot|P07276 Saccharomyces cerevisiae YGR258C RAD2 Single-stranded DNA endonuclease cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA subunit of Nucleotide Excision Repair Factor 3 (NEF3) homolog of human XPG protein; ssDNA endodeoxyribonuclease RAD2 824279 2896490 KLLA0_A09427g Kluyveromyces lactis ssDNA endodeoxyribonuclease RAD2 XP_451412.1 821244 R 28985 CDS KLLA0_A09449g 2896477 825574..827106 A 1 NC_006037.1 similar to uniprot|P53322 Saccharomyces cerevisiae YGR260W TNA1 High affinity nicotinic acid plasma membrane permease; uncharacterized protein 827106 2896477 KLLA0_A09449g Kluyveromyces lactis uncharacterized protein XP_451413.1 825574 D 28985 CDS KLLA0_A09471g 2896485 complement(827264..831784) A 1 NC_006037.1 some similarities with uniprot|P38873 Saccharomyces cerevisiae YHR186C KOG1 Subunit of TORC1 a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p Lst8p and Tco89p contains four HEAT repeats and seven WD-40 repeats may act as a scaffold protein to couple TOR and its effectors; ubiquitin-binding TORC1 subunit KOG1 831784 2896485 KLLA0_A09471g Kluyveromyces lactis ubiquitin-binding TORC1 subunit KOG1 XP_451414.1 827264 R 28985 CDS KLLA0_A09493g 2896331 832430..833317 A 1 NC_006037.1 similar to uniprot|P38874 Saccharomyces cerevisiae YHR187W IKI1 Subunit of the Elp4p-Iki1p-Elp6p-subcomplex of RNA polymerase II elongator complex which is a histone acetyltransferase iki1 mutations confer resistance to the K. lactis toxin zymocin; Elongator subunit IKI1 833317 2896331 KLLA0_A09493g Kluyveromyces lactis Elongator subunit IKI1 XP_451415.1 832430 D 28985 CDS KLLA0_A09515g 2896850 complement(833455..835386) A 1 NC_006037.1 similar to uniprot|P38875 Saccharomyces cerevisiae YHR188C GPI16 Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins human PIG-Tp homolog; GPI-anchor transamidase subunit GPI16 835386 2896850 KLLA0_A09515g Kluyveromyces lactis GPI-anchor transamidase subunit GPI16 XP_451416.1 833455 R 28985 CDS KLLA0_A09537g 2896398 835653..838517 A 1 NC_006037.1 similar to uniprot|P49955 Saccharomyces cerevisiae YMR288W HSH155 U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155; U2 snRNP complex subunit HSH155 838517 2896398 KLLA0_A09537g Kluyveromyces lactis U2 snRNP complex subunit HSH155 XP_451417.1 835653 D 28985 CDS KLLA0_A09559g 2896855 complement(838592..840970) A 1 NC_006037.1 similar to uniprot|P46682 Saccharomyces cerevisiae YGR261C APL6 beta3-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway suppressor of loss of casein kinase 1 function putative beta adaptin component of the membrane-associate clathrin assembly complex; uncharacterized protein 840970 2896855 KLLA0_A09559g Kluyveromyces lactis uncharacterized protein XP_451418.1 838592 R 28985 CDS KLLA0_A09603g 2896321 841883..843100 A 1 NC_006037.1 similar to uniprot|Q03266 Saccharomyces cerevisiae YMR289W ABZ2 4-amino-4-deoxychorismate lyase catalyzes the third step in para-aminobenzoic acid biosynthesis; aminodeoxychorismate lyase ABZ2 843100 2896321 KLLA0_A09603g Kluyveromyces lactis aminodeoxychorismate lyase ABZ2 XP_451419.1 841883 D 28985 CDS KLLA0_A09625g 2896318 complement(843147..843938) A 1 NC_006037.1 highly similar to uniprot|P53323 Saccharomyces cerevisiae YGR262C BUD32 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; serine/threonine protein kinase BUD32 843938 2896318 KLLA0_A09625g Kluyveromyces lactis serine/threonine protein kinase BUD32 XP_451420.1 843147 R 28985 CDS KLLA0_A09647g 2896823 complement(844245..846578) A 1 NC_006037.1 highly similar to uniprot|P00958 Saccharomyces cerevisiae YGR264C MES1 Methionyl-tRNA synthetase forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p which increases the catalytic efficiency of both tRNA synthetases also has a role in nuclear export of tRNAs; methionine--tRNA ligase MES1 846578 2896823 KLLA0_A09647g Kluyveromyces lactis methionine--tRNA ligase MES1 XP_451421.1 844245 R 28985 CDS KLLA0_A09669g 2896371 complement(847036..848529) A 1 NC_006037.1 highly similar to uniprot|Q03532 Saccharomyces cerevisiae YMR290C HAS1 ATP-dependent RNA helicase localizes to both the nuclear periphery and nucleolus highly enriched in nuclear pore complex fractions; ATP-dependent RNA helicase HAS1 848529 2896371 KLLA0_A09669g Kluyveromyces lactis ATP-dependent RNA helicase HAS1 XP_451422.1 847036 R 28985 CDS KLLA0_A09691g 2896333 849221..851305 A 1 NC_006037.1 similar to uniprot|P53326 YGR266W Saccharomyces cerevisiae probably contains a single transmembrane span; uncharacterized protein 851305 2896333 KLLA0_A09691g Kluyveromyces lactis uncharacterized protein XP_451423.1 849221 D 28985 CDS KLLA0_A09713g 2896833 851952..853625 A 1 NC_006037.1 similar to uniprot|Q03533 Saccharomyces cerevisiae YMR291W; protein kinase TDA1 853625 2896833 KLLA0_A09713g Kluyveromyces lactis protein kinase TDA1 XP_451424.1 851952 D 28985 CDS KLLA0_A09735g 2896322 complement(854163..854900) A 1 NC_006037.1 highly similar to uniprot|P51601 YGR267C Saccharomyces cerevisiae FOL2 GTP-cyclohydrolase I; GTP cyclohydrolase I 854900 2896322 KLLA0_A09735g Kluyveromyces lactis GTP cyclohydrolase I XP_451425.1 854163 R 28985 CDS KLLA0_A09757g 2896843 complement(855406..855999) A 1 NC_006037.1 some similarities with uniprot|P40325 YGR268C Saccharomyces cerevisiae HUA1 uncharacterized ORF; uncharacterized protein 855999 2896843 KLLA0_A09757g Kluyveromyces lactis uncharacterized protein XP_451426.1 855406 R 28985 CDS KLLA0_A09779g 2896853 complement(856553..857008) A 1 NC_006037.1 some similarities with uniprot|P40325 Saccharomyces cerevisiae YGR268C; uncharacterized protein 857008 2896853 KLLA0_A09779g Kluyveromyces lactis uncharacterized protein XP_451427.1 856553 R 28985 CDS KLLA0_A09801g 2896377 join(857479..857506,857695..858089) A 1 NC_006037.1 similar to uniprot|Q03554 Saccharomyces cerevisiae YMR292w GOT1 evolutionarily conserved non-essential protein present in early Golgi cisternae that may be involved in ER-Golgi transport at a step after vesicle tethering to Golgi membranes; uncharacterized protein 858089 2896377 KLLA0_A09801g Kluyveromyces lactis uncharacterized protein XP_451428.1 857479 D 28985 CDS KLLA0_A09823g 2896382 858458..862417 A 1 NC_006037.1 similar to uniprot|P40340 Saccharomyces cerevisiae YGR270W YTA7 Protein of unknown function member of CDC48/PAS1/SEC18 family of ATPases potentially phosphorylated by Cdc28p; uncharacterized protein 862417 2896382 KLLA0_A09823g Kluyveromyces lactis uncharacterized protein XP_451429.1 858458 D 28985 CDS KLLA0_A09845g 2896507 complement(862467..863876) A 1 NC_006037.1 similar to uniprot|Q03557 Saccharomyces cerevisiae YMR293C Uncharacterized ORF; glutamyl-tRNA(Gln) amidotransferase subunit HER2 863876 2896507 KLLA0_A09845g Kluyveromyces lactis glutamyl-tRNA(Gln) amidotransferase subunit HER2 XP_451430.1 862467 R 28985 CDS KLLA0_A09867g 2896421 864111..865193 A 1 NC_006037.1 similar to uniprot|Q75D83 Ashbya gossypii ABR141W ABR141Wp and some similarites with YMR294W uniprot|P36224 Saccharomyces cerevisiae YMR294W JNM1 Component of the yeast dynactin complex consisting of Nip100p Jnm1p and Arp1p required for proper nuclear migration and spindle partitioning during mitotic anaphase B; uncharacterized protein 865193 2896421 KLLA0_A09867g Kluyveromyces lactis uncharacterized protein XP_451431.1 864111 D 28985 CDS KLLA0_A09889g 2896409 865422..871304 A 1 NC_006037.1 highly similar to uniprot|P53327 Saccharomyces cerevisiae YGR271W SLH1 SKI2-like helicase; uncharacterized protein 871304 2896409 KLLA0_A09889g Kluyveromyces lactis uncharacterized protein XP_451432.1 865422 D 28985 CDS KLLA0_A09911g 2896384 complement(871390..872076) A 1 NC_006037.1 similar to uniprot|P53328 Saccharomyces cerevisiae YGR272C; uncharacterized protein 872076 2896384 KLLA0_A09911g Kluyveromyces lactis uncharacterized protein XP_451433.1 871390 R 28985 CDS KLLA0_A09933g 2896835 complement(872665..873258) A 1 NC_006037.1 similar to uniprot|Q03559 Saccharomyces cerevisiae YMR295C Protein of unknown function; uncharacterized protein 873258 2896835 KLLA0_A09933g Kluyveromyces lactis uncharacterized protein XP_451434.1 872665 R 28985 CDS KLLA0_A09955g 2896379 complement(873688..875355) A 1 NC_006037.1 similar to uniprot|P25045 Saccharomyces cerevisiae YMR296C LCB1 Component of serine palmitoyltransferase responsible along with Lcb2p for the first committed step in sphingolipid synthesis; serine C-palmitoyltransferase LCB1 875355 2896379 KLLA0_A09955g Kluyveromyces lactis serine C-palmitoyltransferase LCB1 XP_451435.1 873688 R 28985 CDS KLLA0_A09977g 2896412 876594..878201 A 1 NC_006037.1 similar to uniprot|P00729 Saccharomyces cerevisiae YMR297W PRC1 Vacuolar carboxypeptidase Y (proteinase C) involved in protein degradation in the vacuole and required for full protein degradation during sporulation; carboxypeptidase C PRC1 878201 2896412 KLLA0_A09977g Kluyveromyces lactis carboxypeptidase C PRC1 XP_451436.1 876594 D 28985 CDS KLLA0_A09999g 2896365 878563..879006 A 1 NC_006037.1 similar to uniprot|Q03579 Saccharomyces cerevisiae YMR298W Protein required for cell viability; sphingosine N-acyltransferase subunit LIP1 879006 2896365 KLLA0_A09999g Kluyveromyces lactis sphingosine N-acyltransferase subunit LIP1 XP_451437.1 878563 D 28985 CDS KLLA0_A10021g 2896394 complement(879152..882253) A 1 NC_006037.1 similar to uniprot|P46677 YGR274C Saccharomyces cerevisiae TAF1 TFIID subunit (145 kDa) involved in RNA polymerase II transcription initiation; histone acetyltransferase 882253 2896394 KLLA0_A10021g Kluyveromyces lactis histone acetyltransferase XP_451438.1 879152 R 28985 CDS KLLA0_A10043g 2896389 882810..883271 A 1 NC_006037.1 weakly similar to uniprot|P53330 Saccharomyces cerevisiae YGR275W RTT102 Regulator of Ty1 Transposition; regulator of Ty1 transposition; uncharacterized protein 883271 2896389 KLLA0_A10043g Kluyveromyces lactis uncharacterized protein XP_451439.1 882810 D 28985 CDS KLLA0_A10065g 2896387 complement(883467..885515) A 1 NC_006037.1 similar to uniprot|P53331 Saccharomyces cerevisiae YGR276C RNH70 3'exoribonuclease required for 5S and tRNA-Arg3 maturation; uncharacterized protein 885515 2896387 KLLA0_A10065g Kluyveromyces lactis uncharacterized protein XP_451440.1 883467 R 28985 CDS KLLA0_A10087g 2896557 complement(885994..887106) A 1 NC_006037.1 weakly similar to uniprot|Q04949 Saccharomyces cerevisiae YMR299C DYN3 Dynein light intermediate chain (LIC) localizes with dynein null mutant is defective in nuclear migration; dynein light intermediate chain 887106 2896557 KLLA0_A10087g Kluyveromyces lactis dynein light intermediate chain XP_451441.1 885994 R 28985 CDS KLLA0_A10109g 2896821 complement(887498..889027) A 1 NC_006037.1 highly similar to uniprot|P04046 YMR300C Saccharomyces cerevisiae ADE4 Phosphoribosylpyrophosphate amidotransferase; amidophosphoribosyltransferase 889027 2896821 KLLA0_A10109g Kluyveromyces lactis amidophosphoribosyltransferase XP_451442.1 887498 R 28985 CDS KLLA0_A10131g 2896392 complement(889688..891850) A 1 NC_006037.1 similar to uniprot|P40416 Saccharomyces cerevisiae YMR301C ATM1 Mitochondrial inner membrane transporter exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol member of the ATP-binding cassette (ABC) transporter family; ATP-binding cassette Fe/S cluster precursor transporter ATM1 891850 2896392 KLLA0_A10131g Kluyveromyces lactis ATP-binding cassette Fe/S cluster precursor transporter ATM1 XP_451443.1 889688 R 28985 CDS KLLA0_A10153g 2896404 complement(892398..893099) A 1 NC_006037.1 highly similar to uniprot|P40302 Saccharomyces cerevisiae YMR314W PRE5 20S proteasome alpha-type subunit; proteasome core particle subunit alpha 6 893099 2896404 KLLA0_A10153g Kluyveromyces lactis proteasome core particle subunit alpha 6 XP_451444.1 892398 R 28985 CDS KLLA0_A10175g 2896406 893626..895401 A 1 NC_006037.1 similar to uniprot|P40308 Saccharomyces cerevisiae YMR313C TGL3 Triacylglycerol lipase of the lipid particle; bifunctional triglyceride lipase/lysophosphatidylethanolamine acyltransferase 895401 2896406 KLLA0_A10175g Kluyveromyces lactis bifunctional triglyceride lipase/lysophosphatidylethanolamine acyltransferase XP_451445.1 893626 D 28985 CDS KLLA0_A10197g 2896559 complement(895418..896227) A 1 NC_006037.1 similar to uniprot|Q04868 Saccharomyces cerevisiae YMR312W ELP6 Elongator protein part of the HAP subcomplex of Elongator which is a six-subunit component of the RNA polymerase II holoenzyme required for Elongator structural integrity and histone acetyltransferase activity; Elongator subunit ELP6 896227 2896559 KLLA0_A10197g Kluyveromyces lactis Elongator subunit ELP6 XP_451446.1 895418 R 28985 CDS KLLA0_A10219g 2896484 896931..898358 A 1 NC_006037.1 similar to uniprot|Q75BF2 Ashbya gossypii ADL388W ADL388Wp and some similarites with YHR206W uniprot|P38889 Saccharomyces cerevisiae; kinase-regulated stress-responsive transcription factor SKN7 898358 2896484 KLLA0_A10219g Kluyveromyces lactis kinase-regulated stress-responsive transcription factor SKN7 XP_451447.1 896931 D 28985 CDS KLLA0_A10241g 2896390 complement(898752..900230) A 1 NC_006037.1 similar to uniprot|P38890 Saccharomyces cerevisiae YHR207C SET5; S-adenosylmethionine-dependent methyltransferase 900230 2896390 KLLA0_A10241g Kluyveromyces lactis S-adenosylmethionine-dependent methyltransferase XP_451448.1 898752 R 28985 CDS KLLA0_A10263g 2896474 900517..901284 A 1 NC_006037.1 similar to uniprot|P40098 Saccharomyces cerevisiae YER182W FMP10 The authentic non-tagged protein was localized to the mitochondria; uncharacterized protein 901284 2896474 KLLA0_A10263g Kluyveromyces lactis uncharacterized protein XP_451449.1 900517 D 28985 CDS KLLA0_A10285g 2896818 complement(901341..902216) A 1 NC_006037.1 similar to uniprot|P40099 Saccharomyces cerevisiae YER183C FAU1 5 10-methenyltetrahydrofolate synthetase involved in folic acid biosynthesis; 5-formyltetrahydrofolate cyclo-ligase 902216 2896818 KLLA0_A10285g Kluyveromyces lactis 5-formyltetrahydrofolate cyclo-ligase XP_451450.1 901341 R 28985 CDS KLLA0_A10307g 2896849 902374..903597 A 1 NC_006037.1 highly similar to uniprot|P38891 Saccharomyces cerevisiae YHR208W BAT1 Mitochondrial branched-chain amino acid aminotransferase homolog of murine ECA39 highly expressed during logarithmic phase and repressed during stationary phase; branched-chain-amino-acid transaminase BAT1 903597 2896849 KLLA0_A10307g Kluyveromyces lactis branched-chain-amino-acid transaminase BAT1 XP_451451.1 902374 D 28985 CDS KLLA0_A10329g 2896842 903873..905792 A 1 NC_006037.1 conserved hypothetical protein; uncharacterized protein 905792 2896842 KLLA0_A10329g Kluyveromyces lactis uncharacterized protein XP_451452.1 903873 D 28985 CDS KLLA0_A10351g 2896548 complement(906401..907087) A 1 NC_006037.1 weakly similar to uniprot|Q9A7D3 Caulobacter crescentus CC1790 Hypothetical protein CC1790; uncharacterized protein 907087 2896548 KLLA0_A10351g Kluyveromyces lactis uncharacterized protein XP_451453.1 906401 R 28985 CDS KLLA0_A10373g 2896325 complement(907244..907864) A 1 NC_006037.1 some similarities with uniprot|P32805 Saccharomyces cerevisiae YGL254W FZF1 Transcription factor involved in sulfite metabolism sole identified regulatory target is SSU1 overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1 contains five zinc fingers; uncharacterized protein 907864 2896325 KLLA0_A10373g Kluyveromyces lactis uncharacterized protein XP_451454.1 907244 R 28985 CDS KLLA0_A10395g 2896702 complement(908097..908981) A 1 NC_006037.1 similar to uniprot|P53750 Saccharomyces cerevisiae YNR064C; epoxide hydrolase 908981 2896702 KLLA0_A10395g Kluyveromyces lactis epoxide hydrolase XP_451455.1 908097 R 28985 CDS KLLA0_A10417g 2896726 complement(910347..912176) A 1 NC_006037.1 uniprot|Q9Y746 Kluyveromyces lactis KLLA0A10417g INV1 Invertase precursor; beta-fructofuranosidase SUC2 912176 2896726 KLLA0_A10417g Kluyveromyces lactis beta-fructofuranosidase SUC2 XP_451456.1 910347 R 28985 CDS KLLA0_A10439g 2896429 complement(913342..915246) A 1 NC_006037.1 similar to uniprot|P38731 Saccharomyces cerevisiae YHL040C ARN1 Transporter member of the ARN family of transporters that specifically recognize siderophore-iron chelates responsible for uptake of iron bound to ferrirubin ferrirhodin and related siderophores; uncharacterized protein 915246 2896429 KLLA0_A10439g Kluyveromyces lactis uncharacterized protein XP_451457.1 913342 R 28985 CDS KLLA0_A10461g 2896724 916547..917332 A 1 NC_006037.1 similar to uniprot|P36087 Saccharomyces cerevisiae YKL070W; uncharacterized protein 917332 2896724 KLLA0_A10461g Kluyveromyces lactis uncharacterized protein XP_451458.1 916547 D 28985 CDS KLLA0_A10483g 2896781 complement(join(917868..918293,918576..918620)) A 1 NC_006037.1 highly similar to uniprot|P26781 Saccharomyces cerevisiae YDR025w RPS18A or uniprot|P26781 Saccharomyces cerevisiae YBR048w RPS18B ribosomal protein; 40S ribosomal protein uS17 918620 2896781 KLLA0_A10483g Kluyveromyces lactis 40S ribosomal protein uS17 XP_451459.1 917868 R 28985 CDS KLLA0_A10505g 2896671 918705..919115 A 1 NC_006037.1 no similarity; uncharacterized protein 919115 2896671 KLLA0_A10505g Kluyveromyces lactis uncharacterized protein XP_451460.1 918705 D 28985 CDS KLLA0_A10527g 2896416 complement(919456..920004) A 1 NC_006037.1 similar to uniprot|P38231 Saccharomyces cerevisiae YBR047W FMP23 The authentic non-tagged protein was localized to the mitochondria; uncharacterized protein 920004 2896416 KLLA0_A10527g Kluyveromyces lactis uncharacterized protein XP_451461.1 919456 R 28985 CDS KLLA0_A10549g 2896670 921022..922083 A 1 NC_006037.1 highly similar to uniprot|P38230 Saccharomyces cerevisiae YBR046C; NADPH:quinone reductase 922083 2896670 KLLA0_A10549g Kluyveromyces lactis NADPH:quinone reductase XP_451462.1 921022 D 28985 CDS KLLA0_A10571g 2896667 922516..924201 A 1 NC_006037.1 weakly similar to uniprot|P38229 Saccharomyces cerevisiae YBR045C GIP1 Meiosis-specific protein proposed to be a regulatory subunit of the protein phosphatase Glc7p, required for spore wall formation and proper septin organization; protein phosphatase regulator GIP1 924201 2896667 KLLA0_A10571g Kluyveromyces lactis protein phosphatase regulator GIP1 XP_451463.1 922516 D 28985 CDS KLLA0_A10593g 2896393 complement(924496..925875) A 1 NC_006037.1 highly similar to uniprot|P07284 Saccharomyces cerevisiae YDR023W SES1 seryl-tRNA synthetase; serine--tRNA ligase SES1 925875 2896393 KLLA0_A10593g Kluyveromyces lactis serine--tRNA ligase SES1 XP_451464.1 924496 R 28985 CDS KLLA0_A10637g 2896658 926574..927005 A 1 NC_006037.1 weakly similar to uniprot|Q03939 Saccharomyces cerevisiae YDR022C CIS1 Protein involved in microtubule assembly; uncharacterized protein 927005 2896658 KLLA0_A10637g Kluyveromyces lactis uncharacterized protein XP_451465.1 926574 D 28985 CDS KLLA0_A10659g 2896649 complement(927059..928255) A 1 NC_006037.1 highly similar to uniprot|Q12099 Saccharomyces cerevisiae YDR021W FAL1 Nucleolar protein required for maturation of 18S rRNA member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases; ATP-dependent RNA helicase FAL1 928255 2896649 KLLA0_A10659g Kluyveromyces lactis ATP-dependent RNA helicase FAL1 XP_451466.1 927059 R 28985 CDS KLLA0_A10681g 2896660 928563..929657 A 1 NC_006037.1 similar to uniprot|Q08144 Saccharomyces cerevisiae YOL018C TLG2 member of the syntaxin family of t-SNAREs; uncharacterized protein 929657 2896660 KLLA0_A10681g Kluyveromyces lactis uncharacterized protein XP_451467.1 928563 D 28985 CDS KLLA0_A10703g 2896651 complement(929877..931715) A 1 NC_006037.1 some similarities with uniprot|Q08157 Saccharomyces cerevisiae YOL019W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; uncharacterized protein 931715 2896651 KLLA0_A10703g Kluyveromyces lactis uncharacterized protein XP_451468.1 929877 R 28985 CDS KLLA0_A10769g 2896636 933157..933618 A 1 NC_006037.1 similar to uniprot|P43594 Saccharomyces cerevisiae YFR011C; uncharacterized protein 933618 2896636 KLLA0_A10769g Kluyveromyces lactis uncharacterized protein XP_451469.1 933157 D 28985 CDS KLLA0_A10791g 2896629 complement(join(934135..935573,935718..935733)) A 1 NC_006037.1 similar to uniprot|P43593 Saccharomyces cerevisiae YFR010W UBP6 Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome releases free ubiquitin from branched polyubiquitin chains deletion causes hypersensitivity to cycloheximide and other toxic compounds; ubiquitin-specific protease UBP6 935733 2896629 KLLA0_A10791g Kluyveromyces lactis ubiquitin-specific protease UBP6 XP_451470.1 934135 R 28985 CDS KLLA0_A10813g 2896623 complement(936126..937880) A 1 NC_006037.1 similar to uniprot|P38967 Saccharomyces cerevisiae YOL020W TAT2 Tryptophan permease high affinity; aromatic amino acid transmembrane transporter TAT2 937880 2896623 KLLA0_A10813g Kluyveromyces lactis aromatic amino acid transmembrane transporter TAT2 XP_451471.1 936126 R 28985 CDS KLLA0_A10835g 2896617 938712..941738 A 1 NC_006037.1 highly similar to uniprot|Q08162 Saccharomyces cerevisiae YOL021C DIS3 Nucleolar exosome component involved in rRNA processing and RNA degradation binds Gsp1p/Ran and enhances the GEF activity of Srm1p implicated in mitotic control homologous to the E. coli RNase R of the RNase II family; exosome catalytic subunit DIS3 941738 2896617 KLLA0_A10835g Kluyveromyces lactis exosome catalytic subunit DIS3 XP_451472.1 938712 D 28985 CDS KLLA0_A10857g 2896717 complement(941784..944042) A 1 NC_006037.1 highly similar to uniprot|P43535 Saccharomyces cerevisiae YFR009W GCN20 Positive regulator of the Gcn2p kinase activity forms a complex with Gcn1p proposed to stimulate Gcn2p activation by an uncharged tRNA; uncharacterized protein 944042 2896717 KLLA0_A10857g Kluyveromyces lactis uncharacterized protein XP_451473.1 941784 R 28985 CDS KLLA0_A10901g 2896442 945121..946407 A 1 NC_006037.1 similar to uniprot|P25040 Saccharomyces cerevisiae YOL022C Protein required for cell viability; uncharacterized protein 946407 2896442 KLLA0_A10901g Kluyveromyces lactis uncharacterized protein XP_451474.1 945121 D 28985 CDS KLLA0_A10923g 2896601 complement(946489..948501) A 1 NC_006037.1 similar to uniprot|P25038 Saccharomyces cerevisiae YOL023W IFM1 Mitochondrial translation initiation factor 2; translation initiation factor 2 948501 2896601 KLLA0_A10923g Kluyveromyces lactis translation initiation factor 2 XP_451475.1 946489 R 28985 CDS KLLA0_A10945g 2896435 complement(948881..950086) A 1 NC_006037.1 weakly similar to uniprot|P23180 Saccharomyces cerevisiae YHL021C FMP12; uncharacterized protein 950086 2896435 KLLA0_A10945g Kluyveromyces lactis uncharacterized protein XP_451476.1 948881 R 28985 CDS KLLA0_A10967g 2896604 complement(950412..950942) A 1 NC_006037.1 no similarity; uncharacterized protein 950942 2896604 KLLA0_A10967g Kluyveromyces lactis uncharacterized protein XP_451477.1 950412 R 28985 CDS KLLA0_A10989g 2896621 complement(951316..952923) A 1 NC_006037.1 conserved hypothetical protein; uncharacterized protein 952923 2896621 KLLA0_A10989g Kluyveromyces lactis uncharacterized protein XP_451478.1 951316 R 28985 CDS KLLA0_A11011g 2896489 953797..955047 A 1 NC_006037.1 highly similar to uniprot|P00560 Saccharomyces cerevisiae YCR012W PGK1 3-phosphoglycerate kinase catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1 3-bisphosphoglycerate to ADP to produce ATP key enzyme in glycolysis and gluconeogenesis; phosphoglycerate kinase 955047 2896489 KLLA0_A11011g Kluyveromyces lactis phosphoglycerate kinase XP_451479.1 953797 D 28985 CDS KLLA0_A11033g 2896422 complement(955278..956798) A 1 NC_006037.1 weakly similar to uniprot|P25615 Saccharomyces cerevisiae YCR014C POL4 Probable homolog of mammalian DNA polymerase beta may function in double-stranded DNA break repair DNA polymerase IV; DNA-directed DNA polymerase IV 956798 2896422 KLLA0_A11033g Kluyveromyces lactis DNA-directed DNA polymerase IV XP_451480.1 955278 R 28985 CDS KLLA0_A11044g 2896627 complement(956792..957493) A 1 NC_006037.1 some similarities with uniprot|P25616 Saccharomyces cerevisiae YCR015C; uncharacterized protein 957493 2896627 KLLA0_A11044g Kluyveromyces lactis uncharacterized protein XP_451481.1 956792 R 28985 CDS KLLA0_A11066g 2896844 958239..959087 A 1 NC_006037.1 similar to uniprot|P25617 Saccharomyces cerevisiae YCR016W; RNA-binding ribosome assembly factor RBP95 959087 2896844 KLLA0_A11066g Kluyveromyces lactis RNA-binding ribosome assembly factor RBP95 XP_451482.1 958239 D 28985 CDS KLLA0_A11088g 2896397 959342..962446 A 1 NC_006037.1 conserved hypothetical protein; uncharacterized protein 962446 2896397 KLLA0_A11088g Kluyveromyces lactis uncharacterized protein XP_451483.1 959342 D 28985 CDS KLLA0_A11110g 2896650 964084..965739 A 1 NC_006037.1 uniprot|P49374 Kluyveromyces lactis KLLA0A11110g HGT1 High-affinity glucose transporter; uncharacterized protein 965739 2896650 KLLA0_A11110g Kluyveromyces lactis uncharacterized protein XP_451484.1 964084 D 28985 CDS KLLA0_A11132g 2896647 complement(967049..969982) A 1 NC_006037.1 similar to uniprot|P25618 Saccharomyces cerevisiae YCR017C CWH43 Putative sensor/transporter protein involved in cell wall biogenesis contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites null mutation is synthetically lethal with pkc1 deletion; uncharacterized protein 969982 2896647 KLLA0_A11132g Kluyveromyces lactis uncharacterized protein XP_451485.1 967049 R 28985 CDS KLLA0_A11176g 2896528 complement(970974..973133) A 1 NC_006037.1 highly similar to uniprot|P32775 Saccharomyces cerevisiae YEL011W GLC3 Glycogen branching enzyme involved in glycogen accumulation green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; 1,4-alpha-glucan branching enzyme 973133 2896528 KLLA0_A11176g Kluyveromyces lactis 1,4-alpha-glucan branching enzyme XP_451486.1 970974 R 28985 CDS KLLA0_A11198g 2896399 complement(join(973755..974358,974525..974529)) A 1 NC_006037.1 similar to uniprot|P28263 Saccharomyces cerevisiae YEL012W UBC8 Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro; E2 ubiquitin-conjugating protein UBC8 974529 2896399 KLLA0_A11198g Kluyveromyces lactis E2 ubiquitin-conjugating protein UBC8 XP_451487.1 973755 R 28985 CDS KLLA0_A11209g 9487437 complement(974831..975076) A 1 NC_006037.1 similar to uniprot|Q9URQ5 Saccharomyces cerevisiae YCR020W-B HTL1 Subunit of the RSC chromatin remodeling complex, a multisubunit complex that functions in transcriptional regulation,chromosome stability and establishing sister chromatid cohesion; uncharacterized protein 975076 9487437 KLLA0_A11209g Kluyveromyces lactis uncharacterized protein XP_002999350.1 974831 R 28985 CDS KLLA0_A11220g 2896611 975454..975729 A 1 NC_006037.1 similar to uniprot|P23059 Saccharomyces cerevisiae YCR020C-A MAK31 Non-catalytic subunit of N-terminal acetyltransferase of the NatC type required for replication of dsRNA virus member of the Sm protein family; uncharacterized protein 975729 2896611 KLLA0_A11220g Kluyveromyces lactis uncharacterized protein XP_451488.1 975454 D 28985 CDS KLLA0_A11242g 2896640 complement(975786..976844) A 1 NC_006037.1 similar to uniprot|P23060 Saccharomyces cerevisiae YCR019W MAK32 Protein necessary for structural stability of L-A double-stranded RNA-containing particles; uncharacterized protein 976844 2896640 KLLA0_A11242g Kluyveromyces lactis uncharacterized protein XP_451489.1 975786 R 28985 CDS KLLA0_A11286g 2896638 complement(978095..979834) A 1 NC_006037.1 highly similar to uniprot|P39968 Saccharomyces cerevisiae YEL013W VAC8 Phosphorylated vacuolar membrane protein that interacts with Atg13p required for the cytoplasm-to-vacuole targeting (Cvt) pathway interacts with Nvj1p to form nucleus-vacuole junctions; protein anchor VAC8 979834 2896638 KLLA0_A11286g Kluyveromyces lactis protein anchor VAC8 XP_451490.1 978095 R 28985 CDS KLLA0_A11308g 2896643 complement(980616..982022) A 1 NC_006037.1 weakly similar to uniprot|P39998 Saccharomyces cerevisiae YEL015W EDC3 Non-essential conserved protein of unknown function plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p localizes to cytoplasmic mRNA processing bodies; uncharacterized protein 982022 2896643 KLLA0_A11308g Kluyveromyces lactis uncharacterized protein XP_451491.1 980616 R 28985 CDS KLLA0_A11330g 2896668 982552..983124 A 1 NC_006037.1 similar to uniprot|P25378 Saccharomyces cerevisiae YCR027C RHB1 Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins; uncharacterized protein 983124 2896668 KLLA0_A11330g Kluyveromyces lactis uncharacterized protein XP_451492.1 982552 D 28985 CDS KLLA0_A11352g 2896386 complement(983428..984372) A 1 NC_006037.1 some similarities with uniprot|P32573 Saccharomyces cerevisiae YNL202W SPS19 late sporulation specific gene; uncharacterized protein 984372 2896386 KLLA0_A11352g Kluyveromyces lactis uncharacterized protein XP_451493.1 983428 R 28985 CDS KLLA0_A11374g 2896596 complement(985471..987336) A 1 NC_006037.1 some similarities with uniprot|P25353 Saccharomyces cerevisiae YCR026C NPP1; nucleotide diphosphatase/phosphodiesterase NPP2 987336 2896596 KLLA0_A11374g Kluyveromyces lactis nucleotide diphosphatase/phosphodiesterase NPP2 XP_451494.1 985471 R 28985 CDS KLLA0_A11396g 2896696 complement(987998..988912) A 1 NC_006037.1 weakly similar to uniprot|P39996 Saccharomyces cerevisiae YEL017W GTT3 Protein of unknown function with a possible role in glutathione metabolism as suggested by computational analysis of large-scale protein-protein interaction data GFP-fusion protein localizes to the nuclear periphery; uncharacterized protein 988912 2896696 KLLA0_A11396g Kluyveromyces lactis uncharacterized protein XP_451495.1 987998 R 28985 CDS KLLA0_A11440g 2896743 complement(990779..991606) A 1 NC_006037.1 weakly similar to uniprot|P39995 Saccharomyces cerevisiae YEL018W EAF5 Esa1p-associated factor, subunit of the NuA4 acetyltransferase complex; uncharacterized protein 991606 2896743 KLLA0_A11440g Kluyveromyces lactis uncharacterized protein XP_451497.1 990779 R 28985 CDS KLLA0_A11462g 2896721 991845..992615 A 1 NC_006037.1 similar to uniprot|P38632 Saccharomyces cerevisiae YEL019C MMS21 Protein involved in DNA repair mutants are sensitive to the alkylating agent methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination; SUMO ligase MMS21 992615 2896721 KLLA0_A11462g Kluyveromyces lactis SUMO ligase MMS21 XP_451498.1 991845 D 28985 CDS KLLA0_A11484g 2896374 992734..994158 A 1 NC_006037.1 similar to uniprot|P25345 Saccharomyces cerevisiae YCR024C SLM5 Mitochondrial asparaginyl-tRNA synthetase; asparagine--tRNA ligase SLM5 994158 2896374 KLLA0_A11484g Kluyveromyces lactis asparagine--tRNA ligase SLM5 XP_451499.1 992734 D 28985 CDS KLLA0_A11506g 2896376 994478..994870 A 1 NC_006037.1 similar to uniprot|P53903 Saccharomyces cerevisiae YNL149C Protein required for cell viability; uncharacterized protein 994870 2896376 KLLA0_A11506g Kluyveromyces lactis uncharacterized protein XP_451500.1 994478 D 28985 CDS KLLA0_A11528g 2896705 995143..995889 A 1 NC_006037.1 similar to uniprot|P17890 Saccharomyces cerevisiae YNL151C RPC31 RNA polymerase III subunit C31 contains HMG-like C-terminal domain; DNA-directed RNA polymerase III subunit C31 995889 2896705 KLLA0_A11528g Kluyveromyces lactis DNA-directed RNA polymerase III subunit C31 XP_451501.1 995143 D 28985 CDS KLLA0_A11550g 2896655 complement(996087..997151) A 1 NC_006037.1 conserved hypothetical protein; uncharacterized protein 997151 2896655 KLLA0_A11550g Kluyveromyces lactis uncharacterized protein XP_451502.1 996087 R 28985 CDS KLLA0_A11572g 2896771 complement(997457..998623) A 1 NC_006037.1 similar to uniprot|P53901 Saccharomyces cerevisiae YNL152W Protein required for cell viability; uncharacterized protein 998623 2896771 KLLA0_A11572g Kluyveromyces lactis uncharacterized protein XP_451503.1 997457 R 28985 CDS KLLA0_A11594g 2896772 complement(998888..1003480) A 1 NC_006037.1 similar to uniprot|P53552 Saccharomyces cerevisiae YNL139C RLR1 Required for LacZ RNA expression from certain plasmids suppressor of the Transcriptional (T) defect of Hpr1 (H) by Overexpression (O) plays a role in transcription elongation by RNA polymerase II Involved in transcription; uncharacterized protein 1003480 2896772 KLLA0_A11594g Kluyveromyces lactis uncharacterized protein XP_451504.1 998888 R 28985 CDS KLLA0_A11605g 9487484 join(1003776..1003778,1003855..1004115) A 1 NC_006037.1 similar to uniprot|P0C074 Saccharomyces cerevisiae YNL138W-A RCP10 Component of the U2 snRNP, associated with the SF3b complex; conserved in Ashbya gossypii; U2 snRNP complex subunit YSF3 1004115 9487484 KLLA0_A11605g Kluyveromyces lactis U2 snRNP complex subunit YSF3 XP_002999351.1 1003776 D 28985 CDS KLLA0_A11616g 2896372 complement(1004255..1004896) A 1 NC_006037.1 some similarities with uniprot|P38833 Saccharomyces cerevisiae YHR127W (H)igh copy (S)uppressor of (N)34 dominant negative allele of SEC4. Suppression is very specific to this allele. It has no affect on the analogous YPT1 allele. No homology or known function; uncharacterized protein 1004896 2896372 KLLA0_A11616g Kluyveromyces lactis uncharacterized protein XP_451505.1 1004255 R 28985 CDS KLLA0_A11638g 2896762 1005270..1006913 A 1 NC_006037.1 similar to uniprot|P17555 Saccharomyces cerevisiae YNL138W SRV2 Adenylyl cyclase-associated protein N-terminal domain appears to be involved in cellular responsiveness to RAS; adenylate cyclase-binding protein 1006913 2896762 KLLA0_A11638g Kluyveromyces lactis adenylate cyclase-binding protein XP_451506.1 1005270 D 28985 CDS KLLA0_A11660g 2896766 complement(1007120..1008568) A 1 NC_006037.1 similar to uniprot|P27929 Saccharomyces cerevisiae YNL137C NAM9 Mitochondrial ribosomal component of the small subunit; mitochondrial 37S ribosomal protein uS4m 1008568 2896766 KLLA0_A11660g Kluyveromyces lactis mitochondrial 37S ribosomal protein uS4m XP_451507.1 1007120 R 28985 CDS KLLA0_A11682g 2896753 1008960..1010168 A 1 NC_006037.1 some similarities with uniprot|P53911 Saccharomyces cerevisiae YNL136W EAF7 Subunit of the NuA4 histone acetyltransferase complex which acetylates the N-terminal tails of histones H4 and H2A; uncharacterized protein 1010168 2896753 KLLA0_A11682g Kluyveromyces lactis uncharacterized protein XP_451508.1 1008960 D 28985 CDS KLLA0_A11704g 2896522 complement(1010467..1010811) A 1 NC_006037.1 highly similar to uniprot|P20081 Saccharomyces cerevisiae YNL135C FPR1 Peptidyl-prolyl cis-trans isomerase (PPIase) binds to the drugs FK506 and rapamycin also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function; peptidylprolyl isomerase FPR1 1010811 2896522 KLLA0_A11704g Kluyveromyces lactis peptidylprolyl isomerase FPR1 XP_451509.1 1010467 R 28985 CDS KLLA0_A11748g 2896614 1012732..1013991 A 1 NC_006037.1 conserved hypothetical protein; uncharacterized protein 1013991 2896614 KLLA0_A11748g Kluyveromyces lactis uncharacterized protein XP_451511.1 1012732 D 28985 CDS KLLA0_A11770g 2896715 1014918..1016663 A 1 NC_006037.1 similar to uniprot|P06775 Saccharomyces cerevisiae YGR191W HIP1 High-affinity histidine permease also involved in the transport of manganese ions; histidine permease 1016663 2896715 KLLA0_A11770g Kluyveromyces lactis histidine permease XP_451512.1 1014918 D 28985 CDS KLLA0_A11792g 2896708 1017064..1021095 A 1 NC_006037.1 conserved hypothetical protein; uncharacterized protein 1021095 2896708 KLLA0_A11792g Kluyveromyces lactis uncharacterized protein XP_451513.1 1017064 D 28985 CDS KLLA0_A11814g 2896433 1021526..1022434 A 1 NC_006037.1 highly similar to uniprot|P20459 Saccharomyces cerevisiae YJR007W SUI2 Alpha subunit of the translation initiation factor eIF2 involved in the identification of the start codon phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; translation initiation factor eIF2 subunit alpha 1022434 2896433 KLLA0_A11814g Kluyveromyces lactis translation initiation factor eIF2 subunit alpha XP_451514.1 1021526 D 28985 CDS KLLA0_A11836g 2896431 1023063..1024028 A 1 NC_006037.1 similar to uniprot|P47085 Saccharomyces cerevisiae YJR008W; uncharacterized protein 1024028 2896431 KLLA0_A11836g Kluyveromyces lactis uncharacterized protein XP_451515.1 1023063 D 28985 CDS KLLA0_A11858g 2896666 complement(1024297..1025292) A 1 NC_006037.1 highly similar to uniprot|P00358 TDH2, to YGR192C uniprot|P00359 TDH3 and to YJL052W uniprot|P00360 TDH1 Saccharomyces cerevisiae glyceraldehyde 3-phosphate dehydrogenases; uncharacterized protein 1025292 2896666 KLLA0_A11858g Kluyveromyces lactis uncharacterized protein XP_451516.1 1024297 R 28985 CDS KLLA0_A11913g 2896616 1029032..1029448 A 1 NC_006037.1 no similarity; uncharacterized protein 1029448 2896616 KLLA0_A11913g Kluyveromyces lactis uncharacterized protein XP_451519.1 1029032 D 28985 CDS KLLA0_A11935g 2896645 1031062..1034418 A 1 NC_006037.1 some similarities with uniprot|P32768 Saccharomyces cerevisiae YAR050W; uncharacterized protein 1034418 2896645 KLLA0_A11935g Kluyveromyces lactis uncharacterized protein XP_451520.1 1031062 D 28985 CDS KLLA0_A11957g 2896769 1041208..1041834 A 1 NC_006037.1 conserved hypothetical protein; uncharacterized protein 1041834 2896769 KLLA0_A11957g Kluyveromyces lactis uncharacterized protein XP_451521.1 1041208 D 28985 CDS KLLA0_A11979g 2896626 complement(1041901..1043079) A 1 NC_006037.1 some similarities with uniprot|Q87020 Killer virus of S KIL K2 killer toxin precursor; uncharacterized protein 1043079 2896626 KLLA0_A11979g Kluyveromyces lactis uncharacterized protein XP_451522.1 1041901 R 28985 CDS KLLA0_A12001g 2896342 1044941..1045321 A 1 NC_006037.1 no similarity; uncharacterized protein 1045321 2896342 KLLA0_A12001g Kluyveromyces lactis uncharacterized protein XP_451523.2 1044941 D 28985 CDS KLLA0_A12045g 2896779 complement(1048618..1049781) A 1 NC_006037.1 some similarities with uniprot|P53054 Saccharomyces cerevisiae YGL262W; uncharacterized protein 1049781 2896779 KLLA0_A12045g Kluyveromyces lactis uncharacterized protein XP_451524.1 1048618 R 28985 CDS KLLA0_A12067g 2896419 complement(1050804..1051145) A 1 NC_006037.1 conserved hypothetical protein; uncharacterized protein 1051145 2896419 KLLA0_A12067g Kluyveromyces lactis uncharacterized protein XP_451525.1 1050804 R 28985 CDS KLLA0_A12089g 2896824 1052066..1052611 A 1 NC_006037.1 similar to uniprot|Q5WCY3 Bacillus clausii ABC3243 paiA Septation and degradation transcriptional repressor of sporulation; uncharacterized protein 1052611 2896824 KLLA0_A12089g Kluyveromyces lactis uncharacterized protein XP_451526.1 1052066 D 28985 CDS KLLA0_B00143g 2897191 4365..5888 B 1 NC_006038.1 similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport; uncharacterized protein 5888 2897191 KLLA0_B00143g Kluyveromyces lactis uncharacterized protein XP_451535.2 4365 D 28985 CDS KLLA0_B00166g 9487419 complement(6575..6793) B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 6793 9487419 KLLA0_B00166g Kluyveromyces lactis uncharacterized protein XP_002999352.1 6575 R 28985 CDS KLLA0_B00187g 2897212 7994..8317 B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 8317 2897212 KLLA0_B00187g Kluyveromyces lactis uncharacterized protein XP_451537.1 7994 D 28985 CDS KLLA0_B00220g 2897227 complement(8804..9181) B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 9181 2897227 KLLA0_B00220g Kluyveromyces lactis uncharacterized protein XP_451539.1 8804 R 28985 CDS KLLA0_B00242g 2897216 complement(9894..11666) B 1 NC_006038.1 similar to uniprot|Q08295 Saccharomyces cerevisiae YOL157C; uncharacterized protein 11666 2897216 KLLA0_B00242g Kluyveromyces lactis uncharacterized protein XP_451540.1 9894 R 28985 CDS KLLA0_B00264g 2897246 12844..14574 B 1 NC_006038.1 uniprot|Q9Y845 Kluyveromyces lactis mal21 Maltose permease; uncharacterized protein 14574 2897246 KLLA0_B00264g Kluyveromyces lactis uncharacterized protein XP_451541.1 12844 D 28985 CDS KLLA0_B00286g 2896996 complement(15257..16666) B 1 NC_006038.1 similar to uniprot|P24031 Saccharomyces cerevisiae YBR092C PHO3 Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin; uncharacterized protein 16666 2896996 KLLA0_B00286g Kluyveromyces lactis uncharacterized protein XP_451542.1 15257 R 28985 CDS KLLA0_B00308g 2897239 complement(18349..19698) B 1 NC_006038.1 some similarities with uniprot|P32768 Saccharomyces cerevisiae YAR050W; uncharacterized protein 19698 2897239 KLLA0_B00308g Kluyveromyces lactis uncharacterized protein XP_451543.1 18349 R 28985 CDS KLLA0_B00352g 2897272 22476..23972 B 1 NC_006038.1 highly similar to uniprot|Q08902 Saccharomyces cerevisiae YOR378W; uncharacterized protein 23972 2897272 KLLA0_B00352g Kluyveromyces lactis uncharacterized protein XP_451545.1 22476 D 28985 CDS KLLA0_B00385g 2897287 complement(25847..27541) B 1 NC_006038.1 similar to uniprot|P53744 Saccharomyces cerevisiae YNR056C BIO5 Putative transmembrane protein involved in the biotin biosynthesis pathway responsible for uptake of 7-keto 8-aminopelargonic acid BIO5 is in a cluster of 3 genes (BIO3 BIO4 and BIO5) that mediate biotin synthesis; uncharacterized protein 27541 2897287 KLLA0_B00385g Kluyveromyces lactis uncharacterized protein XP_451547.1 25847 R 28985 CDS KLLA0_B00407g 2897303 complement(27872..28558) B 1 NC_006038.1 similar to uniprot|P53630 Saccharomyces cerevisiae YNR057C BIO4 Dethiobiotin synthetase catalyzes the third step in the biotin biosynthesis pathway BIO4 is in a cluster of 3 genes (BIO3 BIO4 and BIO5) that mediate biotin synthesis expression appears to be repressed at low iron levels; dethiobiotin synthase 28558 2897303 KLLA0_B00407g Kluyveromyces lactis dethiobiotin synthase XP_451548.1 27872 R 28985 CDS KLLA0_B00429g 2897419 29147..30598 B 1 NC_006038.1 similar to uniprot|P50277 Saccharomyces cerevisiae YNR058W BIO3 7 8-diamino-pelargonic acid aminotransferase (DAPA) catalyzes the second step in the biotin biosynthesis pathway BIO3 is in a cluster of 3 genes (BIO3 BIO4 and BIO5) that mediate biotin synthesis; adenosylmethionine-8-amino-7-oxononanoate transaminase 30598 2897419 KLLA0_B00429g Kluyveromyces lactis adenosylmethionine-8-amino-7-oxononanoate transaminase XP_451549.1 29147 D 28985 CDS KLLA0_B00451g 2896875 complement(31822..32982) B 1 NC_006038.1 weakly similar to uniprot|P35497 Saccharomyces cerevisiae YJR159W SOR1 Sorbitol dehydrogenase; uncharacterized protein 32982 2896875 KLLA0_B00451g Kluyveromyces lactis uncharacterized protein XP_451550.1 31822 R 28985 CDS KLLA0_B00473g 2897506 complement(35614..36861) B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 36861 2897506 KLLA0_B00473g Kluyveromyces lactis uncharacterized protein XP_451551.1 35614 R 28985 CDS KLLA0_B00495g 2897528 complement(37797..38663) B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 38663 2897528 KLLA0_B00495g Kluyveromyces lactis uncharacterized protein XP_451552.1 37797 R 28985 CDS KLLA0_B00517g 2897211 39267..39893 B 1 NC_006038.1 some similarities with uniprot|Q12034 Saccharomyces cerevisiae YDR515W SLF1 Associates with translating ribosomes; uncharacterized protein 39893 2897211 KLLA0_B00517g Kluyveromyces lactis uncharacterized protein XP_451553.1 39267 D 28985 CDS KLLA0_B00539g 2897197 complement(40064..41737) B 1 NC_006038.1 similar to uniprot|P27697 Saccharomyces cerevisiae YGL119W ABC1 Protein required for ubiquinone (coenzyme Q) biosynthesis which in turn is required for respiratory growth; protein kinase COQ8 41737 2897197 KLLA0_B00539g Kluyveromyces lactis protein kinase COQ8 XP_451554.1 40064 R 28985 CDS KLLA0_B00561g 2897217 42284..44587 B 1 NC_006038.1 highly similar to uniprot|P53131 Saccharomyces cerevisiae YGL120C PRP43 RNA helicase in the DEAH-box family involved in release of the lariat-intron from the spliceosome; DEAH-box ATP-dependent RNA helicase PRP43 44587 2897217 KLLA0_B00561g Kluyveromyces lactis DEAH-box ATP-dependent RNA helicase PRP43 XP_451555.1 42284 D 28985 CDS KLLA0_B00583g 2897233 complement(44819..46279) B 1 NC_006038.1 uniprot|Q00995 Kluyveromyces lactis FOG1 protein; uncharacterized protein 46279 2897233 KLLA0_B00583g Kluyveromyces lactis uncharacterized protein XP_451556.1 44819 R 28985 CDS KLLA0_B00627g 2897295 complement(48523..49098) B 1 NC_006038.1 similar to uniprot|P40018 Saccharomyces cerevisiae YER029C SMB1 associated with U1 U2 U4 and U5 snRNPs as part of the Sm-core that is common to all spliceosomal snRNPs U1 snRNP protein; mRNA splicing protein SMB1 49098 2897295 KLLA0_B00627g Kluyveromyces lactis mRNA splicing protein SMB1 XP_451558.1 48523 R 28985 CDS KLLA0_B00649g 2897385 49535..50053 B 1 NC_006038.1 similar to uniprot|P40019 Saccharomyces cerevisiae YER030W; uncharacterized protein 50053 2897385 KLLA0_B00649g Kluyveromyces lactis uncharacterized protein XP_451559.1 49535 D 28985 CDS KLLA0_B00671g 2897416 complement(join(50393..51006,51417..51462)) B 1 NC_006038.1 highly similar to uniprot|P51996 Saccharomyces cerevisiae YGL210W YPT32 probably involved in intra-Golgi transport or in the formation of transport vesicles at the most distal Golgi compartment; ras-like GTPase, highly homologous to YPT31; Rab family GTPase YPT31 51462 2897416 KLLA0_B00671g Kluyveromyces lactis Rab family GTPase YPT31 XP_451560.2 50393 R 28985 CDS KLLA0_B00693g 2896963 52711..55278 B 1 NC_006038.1 similar to uniprot|P40020 Saccharomyces cerevisiae YER032W FIR1 Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate; uncharacterized protein 55278 2896963 KLLA0_B00693g Kluyveromyces lactis uncharacterized protein XP_451561.1 52711 D 28985 CDS KLLA0_B00715g 2896899 complement(55372..57834) B 1 NC_006038.1 some similarities with uniprot|P40021 Saccharomyces cerevisiae YER033C ZRG8 Cytoplasmic protein of unknown function transcription is induced under conditions of zinc deficiency; uncharacterized protein 57834 2896899 KLLA0_B00715g Kluyveromyces lactis uncharacterized protein XP_451562.1 55372 R 28985 CDS KLLA0_B00737g 2897489 complement(58094..59209) B 1 NC_006038.1 some similarities with uniprot|P53088 Saccharomyces cerevisiae YGL211W NCS6 Protein with a role in urmylation and in invasive and pseudohyphal growth; uncharacterized protein 59209 2897489 KLLA0_B00737g Kluyveromyces lactis uncharacterized protein XP_451563.1 58094 R 28985 CDS KLLA0_B00759g 2896990 59965..61335 B 1 NC_006038.1 some similarities with uniprot|P28742 Saccharomyces cerevisiae YBL063W KIP1 Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation; functionally redundant with Cin8p; uncharacterized protein 61335 2896990 KLLA0_B00759g Kluyveromyces lactis uncharacterized protein XP_451564.1 59965 D 28985 CDS KLLA0_B00781g 2897493 complement(join(61451..61681,61768..61790,61930..61939)) B 1 NC_006038.1 similar to uniprot|Q02647 Saccharomyces cerevisiae YDR424C DYN2 Cytoplasmic light chain dynein microtubule motor protein; dynein light chain 61939 2897493 KLLA0_B00781g Kluyveromyces lactis dynein light chain XP_451565.1 61451 R 28985 CDS KLLA0_B00803g 2897029 62255..63982 B 1 NC_006038.1 weakly similar to uniprot|Q04053 Saccharomyces cerevisiae YDR425W SNX41 Sorting nexin that mediates retrieval from endosomes; uncharacterized protein 63982 2897029 KLLA0_B00803g Kluyveromyces lactis uncharacterized protein XP_451566.1 62255 D 28985 CDS KLLA0_B00825g 2897512 64284..65468 B 1 NC_006038.1 similar to uniprot|Q04062 Saccharomyces cerevisiae YDR427W; proteasome regulatory particle lid subunit RPN9 65468 2897512 KLLA0_B00825g Kluyveromyces lactis proteasome regulatory particle lid subunit RPN9 XP_451567.1 64284 D 28985 CDS KLLA0_B00847g 2897230 complement(65983..66792) B 1 NC_006038.1 similar to uniprot|Q04067 YDR429C Saccharomyces cerevisiae TIF35 Subunit of the core complex of translation initiation factor 3(eIF3); translation initiation factor eIF3 core subunit g 66792 2897230 KLLA0_B00847g Kluyveromyces lactis translation initiation factor eIF3 core subunit g XP_451568.1 65983 R 28985 CDS KLLA0_B00869g 2897266 67723..67938 B 1 NC_006038.1 similar to uniprot|P36533 Saccharomyces cerevisiae YML009C MRPL39 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein bL33m 67938 2897266 KLLA0_B00869g Kluyveromyces lactis mitochondrial 54S ribosomal protein bL33m XP_451569.1 67723 D 28985 CDS KLLA0_B00891g 2897291 complement(68242..71352) B 1 NC_006038.1 similar to uniprot|P27692 YML010W Saccharomyces cerevisiae SPT5 Protein that forms a complex with Spt4p and mediates both activation and inhibition of transcription elongation; transcription elongation factor SPT5 71352 2897291 KLLA0_B00891g Kluyveromyces lactis transcription elongation factor SPT5 XP_451570.1 68242 R 28985 CDS KLLA0_B00913g 2897156 71670..72200 B 1 NC_006038.1 similar to uniprot|Q04231 Saccharomyces cerevisiae YML011C; uncharacterized protein 72200 2897156 KLLA0_B00913g Kluyveromyces lactis uncharacterized protein XP_451571.1 71670 D 28985 CDS KLLA0_B00935g 2897322 complement(72528..73166) B 1 NC_006038.1 similar to uniprot|P54837 Saccharomyces cerevisiae YML012W ERV25 Protein that forms a heterotrimeric complex with Erp1 Erp2p and Emp24 member of the p24 family involved in endoplasmic reticulum to Golgi transport; uncharacterized protein 73166 2897322 KLLA0_B00935g Kluyveromyces lactis uncharacterized protein XP_451572.1 72528 R 28985 CDS KLLA0_B00957g 2897482 complement(73661..76609) B 1 NC_006038.1 similar to uniprot|P32898 YDR430C Saccharomyces cerevisiae CYM1 Cytosolic metalloprotease; pitrilysin family metalloprotease 76609 2897482 KLLA0_B00957g Kluyveromyces lactis pitrilysin family metalloprotease XP_451573.1 73661 R 28985 CDS KLLA0_B00979g 2897501 77439..78467 B 1 NC_006038.1 weakly similar to uniprot|Q01560 YDR432W Saccharomyces cerevisiae NPL3 RNA-binding protein that carries poly(A) mRNA from the nucleus into the cytoplasm; mRNA-binding protein NPL3 78467 2897501 KLLA0_B00979g Kluyveromyces lactis mRNA-binding protein NPL3 XP_451574.1 77439 D 28985 CDS KLLA0_B01001g 2897037 complement(79432..81294) B 1 NC_006038.1 uniprot|Q7ZA19 Kluyveromyces lactis sel1 Secretion lowering protein; uncharacterized protein 81294 2897037 KLLA0_B01001g Kluyveromyces lactis uncharacterized protein XP_451575.1 79432 R 28985 CDS KLLA0_B01023g 2897523 complement(81664..82509) B 1 NC_006038.1 similar to uniprot|P49957 YML014W Saccharomyces cerevisiae TRM9 tRNA methyltransferase; tRNA (carboxymethyluridine(34)-5-O)-methyltransferase 82509 2897523 KLLA0_B01023g Kluyveromyces lactis tRNA (carboxymethyluridine(34)-5-O)-methyltransferase XP_451576.1 81664 R 28985 CDS KLLA0_B01045g 2897128 82972..84522 B 1 NC_006038.1 similar to uniprot|Q04080 YDR434W Saccharomyces cerevisiae GPI17 Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; GPI-anchor transamidase GPI17 84522 2897128 KLLA0_B01045g Kluyveromyces lactis GPI-anchor transamidase GPI17 XP_451577.1 82972 D 28985 CDS KLLA0_B01067g 2897194 84876..85928 B 1 NC_006038.1 similar to uniprot|Q04226 YML015C Saccharomyces cerevisiae TAF11 TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation; TATA-binding protein-associated factor TAF11 85928 2897194 KLLA0_B01067g Kluyveromyces lactis TATA-binding protein-associated factor TAF11 XP_451578.1 84876 D 28985 CDS KLLA0_B01089g 2897248 complement(85996..86997) B 1 NC_006038.1 similar to uniprot|Q04081 YDR435C Saccharomyces cerevisiae PPM1 Carboxyl methyl transferase; leucine carboxy methyltransferase 86997 2897248 KLLA0_B01089g Kluyveromyces lactis leucine carboxy methyltransferase XP_451579.1 85996 R 28985 CDS KLLA0_B01111g 2897337 88088..90067 B 1 NC_006038.1 some similarities with uniprot|P26570 Saccharomyces cerevisiae YML016C PPZ1 Serine/threonine protein phosphatase Z isoform of Ppz2p involved in regulation of potassium transport; salt homeostasis regulator 90067 2897337 KLLA0_B01111g Kluyveromyces lactis salt homeostasis regulator XP_451580.1 88088 D 28985 CDS KLLA0_B01133g 2897404 90746..91141 B 1 NC_006038.1 similar to uniprot|Q04082 Saccharomyces cerevisiae YDR437W Protein required for cell viability; phosphatidylinositol N-acetylglucosaminyltransferase GPI19 91141 2897404 KLLA0_B01133g Kluyveromyces lactis phosphatidylinositol N-acetylglucosaminyltransferase GPI19 XP_451581.1 90746 D 28985 CDS KLLA0_B01155g 2897434 complement(91522..93204) B 1 NC_006038.1 weakly similar to uniprot|P50109 Saccharomyces cerevisiae YML017W PSP2 Asn rich cytoplasmic protein that contains RGG motifs high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha) possible role in mitochondrial mRNA splicing; uncharacterized protein 93204 2897434 KLLA0_B01155g Kluyveromyces lactis uncharacterized protein XP_451582.1 91522 R 28985 CDS KLLA0_B01177g 2897026 94268..95512 B 1 NC_006038.1 similar to uniprot|Q03730 YML018C Saccharomyces cerevisiae; uncharacterized protein 95512 2897026 KLLA0_B01177g Kluyveromyces lactis uncharacterized protein XP_451583.1 94268 D 28985 CDS KLLA0_B01199g 2897445 complement(95848..96846) B 1 NC_006038.1 similar to uniprot|Q03723 Saccharomyces cerevisiae YML019W; dolichyl-diphosphooligosaccharide--protein glycotransferase 96846 2897445 KLLA0_B01199g Kluyveromyces lactis dolichyl-diphosphooligosaccharide--protein glycotransferase XP_451584.1 95848 R 28985 CDS KLLA0_B01221g 2897492 97172..97843 B 1 NC_006038.1 some similarities with uniprot|Q04087 Saccharomyces cerevisiae YDR439W; uncharacterized protein 97843 2897492 KLLA0_B01221g Kluyveromyces lactis uncharacterized protein XP_451585.1 97172 D 28985 CDS KLLA0_B01243g 2897008 complement(97985..99868) B 1 NC_006038.1 similar to uniprot|Q03722 YML020W Saccharomyces cerevisiae; uncharacterized protein 99868 2897008 KLLA0_B01243g Kluyveromyces lactis uncharacterized protein XP_451586.1 97985 R 28985 CDS KLLA0_B01265g 2897204 100414..101430 B 1 NC_006038.1 similar to uniprot|P12887 YML021C Saccharomyces cerevisiae UNG1 uracil DNA glycosylase; uracil-DNA glycosylase 101430 2897204 KLLA0_B01265g Kluyveromyces lactis uracil-DNA glycosylase XP_451587.1 100414 D 28985 CDS KLLA0_B01287g 2896923 101771..103489 B 1 NC_006038.1 similar to uniprot|Q04089 YDR440W Saccharomyces cerevisiae DOT1 Nucleosomal histone H3-Lys79 methylase; histone methyltransferase DOT1 103489 2896923 KLLA0_B01287g Kluyveromyces lactis histone methyltransferase DOT1 XP_451588.1 101771 D 28985 CDS KLLA0_B01309g 2897115 complement(103734..104297) B 1 NC_006038.1 similar to uniprot|P49435 YML022W Saccharomyces cerevisiae APT1 Adenine phosphoribosyltransferase; adenine phosphoribosyltransferase APT2 104297 2897115 KLLA0_B01309g Kluyveromyces lactis adenine phosphoribosyltransferase APT2 XP_451589.1 103734 R 28985 CDS KLLA0_B01331g 2896903 104649..106199 B 1 NC_006038.1 weakly similar to uniprot|Q03718 Saccharomyces cerevisiae YML023C NSE5 Protein required for cell viability; Smc5-Smc6 complex subunit NSE5 106199 2896903 KLLA0_B01331g Kluyveromyces lactis Smc5-Smc6 complex subunit NSE5 XP_451590.1 104649 D 28985 CDS KLLA0_B01353g 2896865 complement(106220..110383) B 1 NC_006038.1 similar to uniprot|P38931 YDR443C Saccharomyces cerevisiae SSN2 Required for stable association of Srb10p-Srb11p kinase with RNA polymerase holoenzyme; uncharacterized protein 110383 2896865 KLLA0_B01353g Kluyveromyces lactis uncharacterized protein XP_451591.1 106220 R 28985 CDS KLLA0_B01375g 2896874 110709..112631 B 1 NC_006038.1 similar to uniprot|Q04093 Saccharomyces cerevisiae YDR444W; uncharacterized protein 112631 2896874 KLLA0_B01375g Kluyveromyces lactis uncharacterized protein XP_451592.1 110709 D 28985 CDS KLLA0_B01397g 2896925 complement(112771..114489) B 1 NC_006038.1 similar to uniprot|P32891 Saccharomyces cerevisiae YDL174C DLD1 D-lactate dehydrogenase oxidizes D-lactate to pyruvate transcription is heme-dependent repressed by glucose and derepressed in ethanol or lactate located in the mitochondrial inner membrane; uncharacterized protein 114489 2896925 KLLA0_B01397g Kluyveromyces lactis uncharacterized protein XP_451593.1 112771 R 28985 CDS KLLA0_B01452g 2896938 115562..116410 B 1 NC_006038.1 weakly similar to uniprot|Q04110 Saccharomyces cerevisiae YDR446W ECM11 Non-essential protein of unknown function GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis may be involved in maintaining chromatin structure; uncharacterized protein 116410 2896938 KLLA0_B01452g Kluyveromyces lactis uncharacterized protein XP_451595.1 115562 D 28985 CDS KLLA0_B01474g 2897012 complement(join(116705..117112,117769..117771)) B 1 NC_006038.1 highly similar to uniprot|P02407 Saccharomyces cerevisiae YML024W RPS17A and to uniprot|P14127 Saccharomyces cerevisiae YDR447C RPS17B Ribosomal proteins 51 (rp51) of the small (40s) subunit; 40S ribosomal protein eS17 117771 2897012 KLLA0_B01474g Kluyveromyces lactis 40S ribosomal protein eS17 XP_451596.2 116705 R 28985 CDS KLLA0_B01496g 2897004 118526..119833 B 1 NC_006038.1 highly similar to uniprot|Q02336 Saccharomyces cerevisiae YDR448W ADA2 Transcription coactivator component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes; chromatin-binding transcription regulator ADA2 119833 2897004 KLLA0_B01496g Kluyveromyces lactis chromatin-binding transcription regulator ADA2 XP_451597.1 118526 D 28985 CDS KLLA0_B01518g 2897055 complement(119927..121291) B 1 NC_006038.1 similar to uniprot|Q02354 Saccharomyces cerevisiae YDR449C UTP6 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; snoRNA-binding rRNA-processing protein UTP6 121291 2897055 KLLA0_B01518g Kluyveromyces lactis snoRNA-binding rRNA-processing protein UTP6 XP_451598.1 119927 R 28985 CDS KLLA0_B01540g 2897092 join(121864..121902,122071..122820) B 1 NC_006038.1 similar to uniprot|P51998 Saccharomyces cerevisiae YML025C YML6 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein uL4m 122820 2897092 KLLA0_B01540g Kluyveromyces lactis mitochondrial 54S ribosomal protein uL4m XP_451599.1 121864 D 28985 CDS KLLA0_B01562g 2897028 join(123623..123669,124200..124593) B 1 NC_006038.1 highly similar to uniprot|P35271 Saccharomyces cerevisiae YML026C RPS18B and to uniprot|P35271 Saccharomyces cerevisiae YDR450W RPS18A proteins component of the small (40S) ribosomal subunit; 40S ribosomal protein uS13 124593 2897028 KLLA0_B01562g Kluyveromyces lactis 40S ribosomal protein uS13 XP_451600.1 123623 D 28985 CDS KLLA0_B01584g 2897180 complement(125027..126421) B 1 NC_006038.1 weakly similar to uniprot|P34161 Saccharomyces cerevisiae YML027W YOX1 Homeodomain-containing transcriptional repressor binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase expression is cell cycle-regulated potential Cdc28p substrate; uncharacterized protein 126421 2897180 KLLA0_B01584g Kluyveromyces lactis uncharacterized protein XP_451601.1 125027 R 28985 CDS KLLA0_B01606g 2897267 127978..130023 B 1 NC_006038.1 similar to uniprot|Q04119 Saccharomyces cerevisiae YDR452W PPN1 Vacuolar endopolyphosphatase with a role in phosphate metabolism functions as a homodimer; endopolyphosphatase 130023 2897267 KLLA0_B01606g Kluyveromyces lactis endopolyphosphatase XP_451602.1 127978 D 28985 CDS KLLA0_B01628g 2897244 complement(130395..130988) B 1 NC_006038.1 highly similar to uniprot|P34760 Saccharomyces cerevisiae YML028W TSA1 and to uniprot|Q04120 Saccharomyces cerevisiae YDR453C TSA2 Thioredoxin- peroxidase; thioredoxin peroxidase TSA2 130988 2897244 KLLA0_B01628g Kluyveromyces lactis thioredoxin peroxidase TSA2 XP_451603.1 130395 R 28985 CDS KLLA0_B01650g 2897344 complement(131822..134395) B 1 NC_006038.1 some similarities with uniprot|Q03714 Saccharomyces cerevisiae YML029W USA1 Protein that interacts in the two-hybrid system with the U1 snRNP-specific protein Snp1p may have a role in pre-mRNA splicing; uncharacterized protein 134395 2897344 KLLA0_B01650g Kluyveromyces lactis uncharacterized protein XP_451604.1 131822 R 28985 CDS KLLA0_B01672g 2897415 complement(134909..135385) B 1 NC_006038.1 similar to uniprot|Q03713 Saccharomyces cerevisiae YML030W; uncharacterized protein 135385 2897415 KLLA0_B01672g Kluyveromyces lactis uncharacterized protein XP_451605.1 134909 R 28985 CDS KLLA0_B01694g 2897427 complement(135778..136356) B 1 NC_006038.1 similar to uniprot|P15454 Saccharomyces cerevisiae YDR454C GUK1 Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins; guanylate kinase 136356 2897427 KLLA0_B01694g Kluyveromyces lactis guanylate kinase XP_451606.2 135778 R 28985 CDS KLLA0_B01738g 2897474 137171..139015 B 1 NC_006038.1 similar to uniprot|Q04121 Saccharomyces cerevisiae YDR456W NHX1 Endosomal Na+/H+ exchanger; bifunctional K:H/Na:H antiporter NHX1 139015 2897474 KLLA0_B01738g Kluyveromyces lactis bifunctional K:H/Na:H antiporter NHX1 XP_451608.1 137171 D 28985 CDS KLLA0_B01760g 2896926 complement(139684..141504) B 1 NC_006038.1 similar to uniprot|P32500 Saccharomyces cerevisiae YML031W NDC1 Nuclear envelope protein with multiple putative transmembrane domains; uncharacterized protein 141504 2896926 KLLA0_B01760g Kluyveromyces lactis uncharacterized protein XP_451609.1 139684 R 28985 CDS KLLA0_B01782g 2896980 142413..143723 B 1 NC_006038.1 uniprot|P41768 Kluyveromyces lactis KLLA0B01782g RAD52 DNA repair and recombination protein RAD52; recombinase RAD52 143723 2896980 KLLA0_B01782g Kluyveromyces lactis recombinase RAD52 XP_451610.1 142413 D 28985 CDS KLLA0_B01804g 2896898 144223..153951 B 1 NC_006038.1 similar to uniprot|Q7LIK7 Saccharomyces cerevisiae YDR457W TOM1 Temperature dependent Organization in Mitotic nucleus; E3 ubiquitin-protein ligase TOM1 153951 2896898 KLLA0_B01804g Kluyveromyces lactis E3 ubiquitin-protein ligase TOM1 XP_451611.1 144223 D 28985 CDS KLLA0_B01826g 2896983 complement(join(155830..156444,156659..158455)) B 1 NC_006038.1 similar to uniprot|Q03707 Saccharomyces cerevisiae YML034W SRC1; uncharacterized protein 158455 2896983 KLLA0_B01826g Kluyveromyces lactis uncharacterized protein XP_451612.1 155830 R 28985 CDS KLLA0_B01848g 2897053 159037..161046 B 1 NC_006038.1 similar to uniprot|Q08968 Saccharomyces cerevisiae YPL222W FMP40 The authentic non-tagged protein was localized to the mitochondria; uncharacterized protein 161046 2897053 KLLA0_B01848g Kluyveromyces lactis uncharacterized protein XP_451613.1 159037 D 28985 CDS KLLA0_B01870g 2897141 161382..162401 B 1 NC_006038.1 no similarity; uncharacterized protein 162401 2897141 KLLA0_B01870g Kluyveromyces lactis uncharacterized protein XP_451614.1 161382 D 28985 CDS KLLA0_B01892g 2897516 162844..165855 B 1 NC_006038.1 weakly similar to uniprot|P36775 Saccharomyces cerevisiae YBL022C PIM1 Mitochondrial ATP-dependent protease involved in intramitochondrial proteolysis involved in degradation of misfolded proteins in mitochondria required for bigenesis and maintenance of mitochondria; uncharacterized protein 165855 2897516 KLLA0_B01892g Kluyveromyces lactis uncharacterized protein XP_451615.1 162844 D 28985 CDS KLLA0_B01914g 2897208 166552..168921 B 1 NC_006038.1 similar to uniprot|Q08967 Saccharomyces cerevisiae YPL221W BOP1 Protein of unknown function overproduction suppresses a pam1 slv3 double null mutation; uncharacterized protein 168921 2897208 KLLA0_B01914g Kluyveromyces lactis uncharacterized protein XP_451616.1 166552 D 28985 CDS KLLA0_B01936g 2897435 complement(169003..170217) B 1 NC_006038.1 weakly similar to uniprot|P53122 Saccharomyces cerevisiae YGL138C; uncharacterized protein 170217 2897435 KLLA0_B01936g Kluyveromyces lactis uncharacterized protein XP_451617.1 169003 R 28985 CDS KLLA0_B01958g 2897447 join(170646..170663,170896..173550) B 1 NC_006038.1 highly similar to uniprot|P41811 Saccharomyces cerevisiae YGL137W SEC27 Involved in beta'-subunit of yeast coatomer; coatomer subunit beta' 173550 2897447 KLLA0_B01958g Kluyveromyces lactis coatomer subunit beta' XP_451618.1 170646 D 28985 CDS KLLA0_B01980g 2896935 complement(173710..174579) B 1 NC_006038.1 similar to uniprot|P53123 Saccharomyces cerevisiae YGL136C MRM2 Mitochondrial 21S rRNA methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ; 21S rRNA (uridine2791-2'-O) methyltransferase 174579 2896935 KLLA0_B01980g Kluyveromyces lactis 21S rRNA (uridine2791-2'-O) methyltransferase XP_451619.1 173710 R 28985 CDS KLLA0_B02002g 2897107 175242..175895 B 1 NC_006038.1 highly similar to uniprot|P53030 Saccharomyces cerevisiae YPL220W RPL1A and to uniprot|P53030 Saccharomyces cerevisiae YPL220W RPL1B N-terminally acetylated protein component of the large (60S) ribosomal subunit; 60S ribosomal protein uL1 175895 2897107 KLLA0_B02002g Kluyveromyces lactis 60S ribosomal protein uL1 XP_451620.1 175242 D 28985 CDS KLLA0_B02024g 2897186 176585..178168 B 1 NC_006038.1 some similarities with uniprot|P53124 Saccharomyces cerevisiae YGL134W PCL10 Pho85p cyclin recruits activates and targets Pho85p cyclin-dependent protein kinase to its substrate; uncharacterized protein 178168 2897186 KLLA0_B02024g Kluyveromyces lactis uncharacterized protein XP_451621.1 176585 D 28985 CDS KLLA0_B02046g 2897293 178646..179218 B 1 NC_006038.1 highly similar to uniprot|P20606 Saccharomyces cerevisiae YPL218W SAR1 GTPase GTP-binding protein of the ARF family component of COPII coat of vesicles required for transport vesicle formation during ER to Golgi protein transport; Arf family GTPase SAR1 179218 2897293 KLLA0_B02046g Kluyveromyces lactis Arf family GTPase SAR1 XP_451622.1 178646 D 28985 CDS KLLA0_B02068g 2897373 complement(179493..182996) B 1 NC_006038.1 similar to uniprot|Q08965 Saccharomyces cerevisiae YPL217C BMS1 Essential conserved nucleolar GTP-binding protein required for synthesis of 40S ribosomal subunits and for processing of the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, has similarity to Tsr1p; GTPase BMS1 182996 2897373 KLLA0_B02068g Kluyveromyces lactis GTPase BMS1 XP_451623.1 179493 R 28985 CDS KLLA0_B02090g 2897334 183718..187077 B 1 NC_006038.1 some similarities with uniprot|P53125 Saccharomyces cerevisiae YGL133W ITC1 Component of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex required for repression of a-specific genes repression of early meiotic genes during mitotic growth and repression of INO1; uncharacterized protein 187077 2897334 KLLA0_B02090g Kluyveromyces lactis uncharacterized protein XP_451624.1 183718 D 28985 CDS KLLA0_B02112g 2897350 187461..188444 B 1 NC_006038.1 similar to uniprot|P21560 Saccharomyces cerevisiae YPL215W CBP3 protein required for assembly of ubiquinol cytochrome-c reductase complex; uncharacterized protein 188444 2897350 KLLA0_B02112g Kluyveromyces lactis uncharacterized protein XP_451625.1 187461 D 28985 CDS KLLA0_B02134g 2897424 complement(188671..190221) B 1 NC_006038.1 similar to uniprot|P41835 Saccharomyces cerevisiae YPL214C THI6 bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities; bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase 190221 2897424 KLLA0_B02134g Kluyveromyces lactis bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase XP_451626.1 188671 R 28985 CDS KLLA0_B02156g 2896945 190619..191347 B 1 NC_006038.1 weakly similar to uniprot|Q08963 Saccharomyces cerevisiae YPL213W LEA1 Component of U2 snRNP disruption causes reduced U2 snRNP levels physically interacts with Msl1p putative homolog of human U2A' snRNP protein; U2 snRNP complex subunit LEA1 191347 2896945 KLLA0_B02156g Kluyveromyces lactis U2 snRNP complex subunit LEA1 XP_451627.1 190619 D 28985 CDS KLLA0_B02178g 2896994 complement(191448..195965) B 1 NC_006038.1 similar to uniprot|P53127 Saccharomyces cerevisiae YGL131C SNT2 22% sequence identity with S. pombe Snt2; DNA-binding E3 ubiquitin-protein ligase SNT2 195965 2896994 KLLA0_B02178g Kluyveromyces lactis DNA-binding E3 ubiquitin-protein ligase SNT2 XP_451628.1 191448 R 28985 CDS KLLA0_B02200g 2897021 196341..197741 B 1 NC_006038.1 highly similar to uniprot|Q01159 Saccharomyces cerevisiae YGL130W CEG1 mRNA guanylyltransferase (mRNA capping enzyme), alpha subunit; mRNA guanylyltransferase 197741 2897021 KLLA0_B02200g Kluyveromyces lactis mRNA guanylyltransferase XP_451629.1 196341 D 28985 CDS KLLA0_B02222g 2897515 complement(197850..199157) B 1 NC_006038.1 similar to uniprot|Q01163 Saccharomyces cerevisiae YGL129C RSM23 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein mS29 199157 2897515 KLLA0_B02222g Kluyveromyces lactis mitochondrial 37S ribosomal protein mS29 XP_451630.1 197850 R 28985 CDS KLLA0_B02244g 2897526 complement(199514..201175) B 1 NC_006038.1 similar to uniprot|Q12211 Saccharomyces cerevisiae YPL212C PUS1 Involved in tRNA biogenesis intranuclear protein which exhibits a nucleotide-specific intron-dependent tRNA pseudouridine synthase activity; uncharacterized protein 201175 2897526 KLLA0_B02244g Kluyveromyces lactis uncharacterized protein XP_451631.1 199514 R 28985 CDS KLLA0_B02266g 2897307 201752..202297 B 1 NC_006038.1 highly similar to uniprot|Q08962 Saccharomyces cerevisiae YPL211W NIP7 Nucleolar protein required for 60S ribosome subunit biogenesis; ribosome biosynthesis protein NIP7 202297 2897307 KLLA0_B02266g Kluyveromyces lactis ribosome biosynthesis protein NIP7 XP_451632.1 201752 D 28985 CDS KLLA0_B02288g 2897370 complement(202601..204517) B 1 NC_006038.1 weakly similar to uniprot|P38688 Saccharomyces cerevisiae YPL210C SRP72 Component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane; signal recognition particle subunit SRP72 204517 2897370 KLLA0_B02288g Kluyveromyces lactis signal recognition particle subunit SRP72 XP_451633.1 202601 R 28985 CDS KLLA0_B02310g 2897400 205046..206800 B 1 NC_006038.1 similar to uniprot|P53166 Saccharomyces cerevisiae YGL064C MRH4 Mitochondrial RNA helicase plays an essential role in mitochondrial function; ATP-dependent RNA helicase 206800 2897400 KLLA0_B02310g Kluyveromyces lactis ATP-dependent RNA helicase XP_451634.1 205046 D 28985 CDS KLLA0_B02332g 2897422 complement(206863..207948) B 1 NC_006038.1 similar to uniprot|P38991 Saccharomyces cerevisiae YPL209C IPL1 Aurora kinase involved in regulating kinetochore-microtubule attachments associates with Sli5p which stimulates Ipl1p kinase activity and promotes its association with the mitotic spindle potential Cdc28p substrate; aurora kinase 207948 2897422 KLLA0_B02332g Kluyveromyces lactis aurora kinase XP_451635.1 206863 R 28985 CDS KLLA0_B02354g 2896958 208684..210468 B 1 NC_006038.1 similar to uniprot|Q08961 Saccharomyces cerevisiae YPL208W; protein-lysine N-methyltransferase 210468 2896958 KLLA0_B02354g Kluyveromyces lactis protein-lysine N-methyltransferase XP_451636.1 208684 D 28985 CDS KLLA0_B02376g 2896911 210877..211275 B 1 NC_006038.1 no similarity; uncharacterized protein 211275 2896911 KLLA0_B02376g Kluyveromyces lactis uncharacterized protein XP_451637.1 210877 D 28985 CDS KLLA0_B02398g 2896860 complement(211618..212844) B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 212844 2896860 KLLA0_B02398g Kluyveromyces lactis uncharacterized protein XP_451638.1 211618 R 28985 CDS KLLA0_B02420g 2896861 213115..214626 B 1 NC_006038.1 similar to uniprot|P43636 Saccharomyces cerevisiae YGL065C ALG2 Mannosyltransferase mannosylates Man2GlcNAc2-PP-Dol to form Man3GlcNAc2-PP-Dol which is a precursor required for asparagine-linked protein glycosylation; GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase 214626 2896861 KLLA0_B02420g Kluyveromyces lactis GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase XP_451639.1 213115 D 28985 CDS KLLA0_B02442g 2897502 complement(214743..216218) B 1 NC_006038.1 some similarities with uniprot|P53165 Saccharomyces cerevisiae YGL066W SGF73 SaGa associated Factor 73kDa Probable 73KkDa Subunit of SAGA histone acetyltransferase complex; deubiquitination module subunit SGF73 216218 2897502 KLLA0_B02442g Kluyveromyces lactis deubiquitination module subunit SGF73 XP_451640.1 214743 R 28985 CDS KLLA0_B02464g 2897059 complement(216794..217747) B 1 NC_006038.1 similar to uniprot|Q08959 Saccharomyces cerevisiae YPL206C Endoplasmic reticulum protein of unknown function; phosphatidylglycerol phospholipase 217747 2897059 KLLA0_B02464g Kluyveromyces lactis phosphatidylglycerol phospholipase XP_451641.2 216794 R 28985 CDS KLLA0_B02519g 2897364 219931..221025 B 1 NC_006038.1 similar to uniprot|P32464 Saccharomyces cerevisiae YKL189W HYM1 Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis interacts with Kic1p and Sog2p localizes to sites of polarized growth during budding and during the mating response; uncharacterized protein 221025 2897364 KLLA0_B02519g Kluyveromyces lactis uncharacterized protein XP_451644.1 219931 D 28985 CDS KLLA0_B02541g 2897375 complement(221104..222636) B 1 NC_006038.1 similar to uniprot|Q06696 Saccharomyces cerevisiae YLR417W VPS36 Component of the ESCRT-II complex which is involved in ubiquitin-dependent sorting of proteins into the endosome; ESCRT-II subunit protein VPS36 222636 2897375 KLLA0_B02541g Kluyveromyces lactis ESCRT-II subunit protein VPS36 XP_451645.1 221104 R 28985 CDS KLLA0_B02563g 2897401 complement(222951..225377) B 1 NC_006038.1 similar to uniprot|P34230 Saccharomyces cerevisiae YKL188C PXA2 Homolog of the human adrenoleukodystrophy transporter forms a heterodimer with Pxa1p of two half ATP-binding cassette transporters in the peroxisome membrane peroxisomal ABC transporter 2; ATP-binding cassette long-chain fatty acid transporter PXA2 225377 2897401 KLLA0_B02563g Kluyveromyces lactis ATP-binding cassette long-chain fatty acid transporter PXA2 XP_451646.1 222951 R 28985 CDS KLLA0_B02585g 2896916 226764..227561 B 1 NC_006038.1 similar to uniprot|Q6B322 Saccharomyces cerevisiae YLR414C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm and bud; uncharacterized protein 227561 2896916 KLLA0_B02585g Kluyveromyces lactis uncharacterized protein XP_451647.1 226764 D 28985 CDS KLLA0_B02607g 2897483 complement(228049..230112) B 1 NC_006038.1 weakly similar to uniprot|P34231 Saccharomyces cerevisiae YKL187C and weakly similar to uniprot|Q06689 Saccharomyces cerevisiae YLR413W; uncharacterized protein 230112 2897483 KLLA0_B02607g Kluyveromyces lactis uncharacterized protein XP_451648.1 228049 R 28985 CDS KLLA0_B02629g 2896871 complement(231874..232410) B 1 NC_006038.1 similar to uniprot|P34232 Saccharomyces cerevisiae YKL186C MTR2 mRNA transport regulator essential nuclear protein Mex67p and Mtr2p form a mRNA export complex which binds to RNA; uncharacterized protein 232410 2896871 KLLA0_B02629g Kluyveromyces lactis uncharacterized protein XP_451649.1 231874 R 28985 CDS KLLA0_B02651g 2897016 233553..234935 B 1 NC_006038.1 weakly similar to uniprot|P34233 Saccharomyces cerevisiae YKL185W ASH1 Zinc-finger inhibitor of HO transcription mRNA is localized and translated in the distal tip of anaphase cells resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression potential Cdc28p substrate; DNA-binding transcription repressor ASH1 234935 2897016 KLLA0_B02651g Kluyveromyces lactis DNA-binding transcription repressor ASH1 XP_451650.1 233553 D 28985 CDS KLLA0_B02673g 2897080 235478..236803 B 1 NC_006038.1 similar to uniprot|P08432 Saccharomyces cerevisiae YKL184W SPE1 Rate limiting step of polyamine biosynthesis pathway Ornithine decarboxylase; ornithine decarboxylase SPE1 236803 2897080 KLLA0_B02673g Kluyveromyces lactis ornithine decarboxylase SPE1 XP_451651.1 235478 D 28985 CDS KLLA0_B02695g 2897043 237221..238120 B 1 NC_006038.1 similar to uniprot|P34234 Saccharomyces cerevisiae YKL183W LOT5 Protein of unknown function gene expression increases in cultures shifted to a lower temperature; uncharacterized protein 238120 2897043 KLLA0_B02695g Kluyveromyces lactis uncharacterized protein XP_451652.1 237221 D 28985 CDS KLLA0_B02717g 2897129 240125..246268 B 1 NC_006038.1 highly similar to uniprot|P07149 Saccharomyces cerevisiae YKL182W FAS1 Beta subunit of fatty acid synthetase which catalyzes the synthesis of long-chain saturated fatty acids contains acetyltransacylase dehydratase enoyl reductase malonyl transacylase and palmitoyl transacylase activities; tetrafunctional fatty acid synthase subunit FAS1 246268 2897129 KLLA0_B02717g Kluyveromyces lactis tetrafunctional fatty acid synthase subunit FAS1 XP_451653.1 240125 D 28985 CDS KLLA0_B02739g 2897149 complement(246730..247590) B 1 NC_006038.1 similar to uniprot|Q06688 Saccharomyces cerevisiae YLR412W; uncharacterized protein 247590 2897149 KLLA0_B02739g Kluyveromyces lactis uncharacterized protein XP_451654.1 246730 R 28985 CDS KLLA0_B02783g 2897345 248299..249552 B 1 NC_006038.1 highly similar to uniprot|P32895 Saccharomyces cerevisiae YKL181W PRS1 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase involved in nucleotide histidine and tryptophan biosynthesis one of five related enzymes which are active as heteromultimeric complexes; ribose phosphate diphosphokinase subunit PRS1 249552 2897345 KLLA0_B02783g Kluyveromyces lactis ribose phosphate diphosphokinase subunit PRS1 XP_451656.1 248299 D 28985 CDS KLLA0_B02805g 2897318 complement(250482..253904) B 1 NC_006038.1 similar to uniprot|Q06685 Saccharomyces cerevisiae YLR410W VIP1 Homologous to S. pombe asp1; inositol polyphosphate kinase VIP1 253904 2897318 KLLA0_B02805g Kluyveromyces lactis inositol polyphosphate kinase VIP1 XP_451657.1 250482 R 28985 CDS KLLA0_B02827g 2897420 254447..257275 B 1 NC_006038.1 highly similar to uniprot|Q06078 Saccharomyces cerevisiae YLR409C UTP21 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA based on computational analysis of large-scale protein-protein interaction data; rRNA-processing protein UTP21 257275 2897420 KLLA0_B02827g Kluyveromyces lactis rRNA-processing protein UTP21 XP_451658.1 254447 D 28985 CDS KLLA0_B02849g 2897548 complement(257299..260280) B 1 NC_006038.1 similar to uniprot|Q07468 Saccharomyces cerevisiae YDL077C VAM6 Protein involved in vacuolar morphogenesis; uncharacterized protein 260280 2897548 KLLA0_B02849g Kluyveromyces lactis uncharacterized protein XP_451659.1 257299 R 28985 CDS KLLA0_B02871g 2896912 260566..260880 B 1 NC_006038.1 similar to YLR408c; uncharacterized protein 260880 2896912 KLLA0_B02871g Kluyveromyces lactis uncharacterized protein XP_451660.1 260566 D 28985 CDS KLLA0_B02893g 2896910 complement(261089..261781) B 1 NC_006038.1 similar to uniprot|Q06070 Saccharomyces cerevisiae YLR407W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; uncharacterized protein 261781 2896910 KLLA0_B02893g Kluyveromyces lactis uncharacterized protein XP_451661.1 261089 R 28985 CDS KLLA0_B02915g 2896887 complement(262455..263420) B 1 NC_006038.1 similar to uniprot|Q07458 Saccharomyces cerevisiae YDL076C RXT3; uncharacterized protein 263420 2896887 KLLA0_B02915g Kluyveromyces lactis uncharacterized protein XP_451662.1 262455 R 28985 CDS KLLA0_B02937g 2896929 join(264277..264333,264903..265190) B 1 NC_006038.1 highly similar to uniprot|P04649 Saccharomyces cerevisiae YDL075W RPL31A and to YLR406C uniprot|P04649 Saccharomyces cerevisiae YLR406C RPL31B, Protein component of the large (60S) ribosomal subunit; 60S ribosomal protein eL31 265190 2896929 KLLA0_B02937g Kluyveromyces lactis 60S ribosomal protein eL31 XP_451663.1 264277 D 28985 CDS KLLA0_B02959g 2896974 complement(266267..267322) B 1 NC_006038.1 highly similar to uniprot|Q757D8 Ashbya gossypii AER075W AER075Wp and similar to YLR405W uniprot|Q06063 Saccharomyces cerevisiae YLR405W DUS4 Dihydrouridine synthase member of a widespread family of conserved proteins including Smm1p Dus1p and Dus3p; tRNA dihydrouridine synthase 267322 2896974 KLLA0_B02959g Kluyveromyces lactis tRNA dihydrouridine synthase XP_451664.1 266267 R 28985 CDS KLLA0_B02981g 2897020 complement(267798..269789) B 1 NC_006038.1 similar to uniprot|Q07457 Saccharomyces cerevisiae YDL074C BRE1 E3 ubiquitin ligase for Rad6p required for the ubiquitination of histone H2B recruitment of Rad6p to promoter chromatin and subsequent methylation of histone H3 (on L4 and L79) contains RING finger domain; E3 ubiquitin-protein ligase BRE1 269789 2897020 KLLA0_B02981g Kluyveromyces lactis E3 ubiquitin-protein ligase BRE1 XP_451665.1 267798 R 28985 CDS KLLA0_B03003g 2897076 270824..273865 B 1 NC_006038.1 weakly similar to uniprot|Q07454 Saccharomyces cerevisiae YDL073W; uncharacterized protein 273865 2897076 KLLA0_B03003g Kluyveromyces lactis uncharacterized protein XP_451666.1 270824 D 28985 CDS KLLA0_B03025g 2897084 complement(274064..274762) B 1 NC_006038.1 weakly similar to uniprot|Q06058 Saccharomyces cerevisiae YLR404W; seipin 274762 2897084 KLLA0_B03025g Kluyveromyces lactis seipin XP_451667.1 274064 R 28985 CDS KLLA0_B03047g 2897121 complement(275298..277343) B 1 NC_006038.1 similar to uniprot|P32432 Saccharomyces cerevisiae YLR403W SFP1 Transcription factor that integrates information from nutrient- and stress-responsive signaling pathways to help control ribosomal protein gene expression inhibits nuclear protein localization when present in multiple copies; zinc-coordinating transcription factor SFP1 277343 2897121 KLLA0_B03047g Kluyveromyces lactis zinc-coordinating transcription factor SFP1 XP_451668.1 275298 R 28985 CDS KLLA0_B03069g 2897347 278510..280507 B 1 NC_006038.1 similar to uniprot|Q06053 Saccharomyces cerevisiae YLR401C DUS3 Dihydrouridine synthase member of a widespread family of conserved proteins including Smm1p Dus1p and Dus4p contains a consensus oleate response element (ORE) in its promoter region; tRNA dihydrouridine synthase DUS3 280507 2897347 KLLA0_B03069g Kluyveromyces lactis tRNA dihydrouridine synthase DUS3 XP_451669.1 278510 D 28985 CDS KLLA0_B03091g 2897421 complement(280664..281398) B 1 NC_006038.1 similar to uniprot|Q7LGS8 Saccharomyces cerevisiae YDL072C YET3 Endoplasmic reticulum transmembrane protein homolog of human BAP31 protein; uncharacterized protein 281398 2897421 KLLA0_B03091g Kluyveromyces lactis uncharacterized protein XP_451670.1 280664 R 28985 CDS KLLA0_B03113g 2897470 282503..284488 B 1 NC_006038.1 similar to uniprot|P35817 Saccharomyces cerevisiae YLR399C BDF1 Protein involved in transcription initiation at TATA-containing promoters associates with the basal transcription factor TFIID contains two bromodomains corresponds to the C-terminal region of mammalian TAF1 redundant with Bdf2p; chromatin-binding protein BDF1 284488 2897470 KLLA0_B03113g Kluyveromyces lactis chromatin-binding protein BDF1 XP_451671.1 282503 D 28985 CDS KLLA0_B03135g 2896915 285346..286728 B 1 NC_006038.1 uniprot|Q9Y761 Kluyveromyces lactis KLLA0B03135g GNT1 Glucose N-acetyltransferase 1-A; uncharacterized protein 286728 2896915 KLLA0_B03135g Kluyveromyces lactis uncharacterized protein XP_451672.1 285346 D 28985 CDS KLLA0_B03157g 2897052 287677..288663 B 1 NC_006038.1 uniprot|Q00974 Kluyveromyces lactis KLLA0B03157g YEA4 UDP-N-acetylglucosamine transporter YEA4; uncharacterized protein 288663 2897052 KLLA0_B03157g Kluyveromyces lactis uncharacterized protein XP_451673.1 287677 D 28985 CDS KLLA0_B03179g 2896946 289199..292204 B 1 NC_006038.1 similar to uniprot|P35207 Saccharomyces cerevisiae YLR398C SKI2 blocks translation of non-poly(A) mRNAs antiviral protein putative helicase; SKI complex RNA helicase subunit SKI2 292204 2896946 KLLA0_B03179g Kluyveromyces lactis SKI complex RNA helicase subunit SKI2 XP_451674.1 289199 D 28985 CDS KLLA0_B03212g 2897134 complement(293080..293682) B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 293682 2897134 KLLA0_B03212g Kluyveromyces lactis uncharacterized protein XP_451676.1 293080 R 28985 CDS KLLA0_B03234g 2897140 293919..296333 B 1 NC_006038.1 similar to uniprot|P32794 Saccharomyces cerevisiae YLR397C AFG2 ATPase of the CDC48/PAS1/SEC18 (AAA) family forms a hexameric complex may be involved in degradation of aberrant mRNAs; AAA family ATPase AFG2 296333 2897140 KLLA0_B03234g Kluyveromyces lactis AAA family ATPase AFG2 XP_451677.1 293919 D 28985 CDS KLLA0_B03267g 2897389 296600..298519 B 1 NC_006038.1 weakly similar to uniprot|P20795 Saccharomyces cerevisiae YLR396C VPS33 vacuolar sorting protein essential for vacuolar morphogenesis and function involved in vacuolar protein targeting; tethering complex ATP-binding subunit VPS33 298519 2897389 KLLA0_B03267g Kluyveromyces lactis tethering complex ATP-binding subunit VPS33 XP_451679.1 296600 D 28985 CDS KLLA0_B03289g 2897436 complement(299377..299559) B 1 NC_006038.1 highly similar to uniprot|P07255 Saccharomyces cerevisiae YDL067C COX9 Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; cytochrome c oxidase subunit VIIa 299559 2897436 KLLA0_B03289g Kluyveromyces lactis cytochrome c oxidase subunit VIIa XP_451680.1 299377 R 28985 CDS KLLA0_B03311g 2897403 300590..300811 B 1 NC_006038.1 highly similar to uniprot|Q757F1 Ashbya gossypii AER062C AER062Cp and similar to YLR395C uniprot|P04039 Saccharomyces cerevisiae YLR395C COX8 Subunit VIII of cytochrome c oxidase which is the terminal member of the mitochondrial inner membrane electron transport chain; cytochrome c oxidase subunit VIII 300811 2897403 KLLA0_B03311g Kluyveromyces lactis cytochrome c oxidase subunit VIII XP_451681.1 300590 D 28985 CDS KLLA0_B03333g 2897488 complement(301536..302480) B 1 NC_006038.1 some similarities with uniprot|Q06032 Saccharomyces cerevisiae YLR394W CST9 Protein required for synaptonemal complex formation may have a role in meiotic recombination localizes to synapsis initiation sites on meiotic chromosomes potential Cdc28p substrate; SUMO ligase CST9 302480 2897488 KLLA0_B03333g Kluyveromyces lactis SUMO ligase CST9 XP_451682.1 301536 R 28985 CDS KLLA0_B03355g 2896905 303444..304733 B 1 NC_006038.1 highly similar to uniprot|P21954 Saccharomyces cerevisiae YDL066W IDP1 Mitochondrial NADP-specific isocitrate dehydrogenase catalyzes the oxidation of isocitrate to alpha-ketoglutarate not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes; isocitrate dehydrogenase (NADP(+)) IDP1 304733 2896905 KLLA0_B03355g Kluyveromyces lactis isocitrate dehydrogenase (NADP(+)) IDP1 XP_451683.1 303444 D 28985 CDS KLLA0_B03377g 2897477 305323..306120 B 1 NC_006038.1 highly similar to uniprot|P14020 Saccharomyces cerevisiae YPR183W DPM1 Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man required for glycosyl phosphatidylinositol membrane anchoring O mannosylation and protein glycosylation; dolichyl-phosphate beta-D-mannosyltransferase 306120 2897477 KLLA0_B03377g Kluyveromyces lactis dolichyl-phosphate beta-D-mannosyltransferase XP_451684.1 305323 D 28985 CDS KLLA0_B03432g 2896881 311810..313864 B 1 NC_006038.1 some similarities with uniprot|Q06628 Saccharomyces cerevisiae YPR185W ATG13 Phosphorylated protein that interacts with Vac8p required for the cytoplasm-to-vacuole targeting (Cvt) pathway and autophagy; serine/threonine protein kinase regulatory subunit ATG13 313864 2896881 KLLA0_B03432g Kluyveromyces lactis serine/threonine protein kinase regulatory subunit ATG13 XP_451687.1 311810 D 28985 CDS KLLA0_B03454g 2896922 complement(314015..315433) B 1 NC_006038.1 similar to uniprot|P39933 Saccharomyces cerevisiae YPR186C PZF1 Transcription factor IIIA (TFIIIA) with putative Zn-fingers; uncharacterized protein 315433 2896922 KLLA0_B03454g Kluyveromyces lactis uncharacterized protein XP_451688.1 314015 R 28985 CDS KLLA0_B03476g 2896933 join(315833..315852,315984..316440) B 1 NC_006038.1 highly similar to uniprot|P20435 Saccharomyces cerevisiae YPR187W RPO26 RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit; DNA-directed RNA polymerase core subunit RPO26 316440 2896933 KLLA0_B03476g Kluyveromyces lactis DNA-directed RNA polymerase core subunit RPO26 XP_451689.1 315833 D 28985 CDS KLLA0_B03498g 2896940 complement(316552..317016) B 1 NC_006038.1 similar to uniprot|Q06580 Saccharomyces cerevisiae YPR188C MLC2 Regulatory light chain for the type II myosin Myo1p binds to an IQ motif of Myo1p localization to the bud neck depends on Myo1p involved in the disassembly of the Myo1p ring; uncharacterized protein 317016 2896940 KLLA0_B03498g Kluyveromyces lactis uncharacterized protein XP_451690.1 316552 R 28985 CDS KLLA0_B03520g 2897002 317409..321614 B 1 NC_006038.1 similar to uniprot|P17883 Saccharomyces cerevisiae YPR189W SKI3 dsRNA virus protection family member contains 8 copies of the tetratricopeptide (TPR) domain; SKI complex subunit tetratricopeptide repeat protein SKI3 321614 2897002 KLLA0_B03520g Kluyveromyces lactis SKI complex subunit tetratricopeptide repeat protein SKI3 XP_451691.1 317409 D 28985 CDS KLLA0_B03542g 2896978 complement(321676..323649) B 1 NC_006038.1 similar to uniprot|P32349 Saccharomyces cerevisiae YPR190C RPC82 RNA polymerase III subunit C82; DNA-directed RNA polymerase III subunit C82 323649 2896978 KLLA0_B03542g Kluyveromyces lactis DNA-directed RNA polymerase III subunit C82 XP_451692.1 321676 R 28985 CDS KLLA0_B03564g 2897081 324536..325618 B 1 NC_006038.1 similar to uniprot|P07257 Saccharomyces cerevisiae YPR191W QCR2 40 kDa ubiquinol cytochrome-c reductase core protein 2; ubiquinol--cytochrome-c reductase subunit 2 325618 2897081 KLLA0_B03564g Kluyveromyces lactis ubiquinol--cytochrome-c reductase subunit 2 XP_451693.1 324536 D 28985 CDS KLLA0_B03586g 2897504 complement(326871..329075) B 1 NC_006038.1 similar to uniprot|P11792 Saccharomyces cerevisiae YHR205W SCH9 protein kinase involved in growth control may be redundant with cAMP pathway cAMP-dependent protein kinase homolog suppressor of cdc25ts; serine/threonine protein kinase SCH9 329075 2897504 KLLA0_B03586g Kluyveromyces lactis serine/threonine protein kinase SCH9 XP_451694.1 326871 R 28985 CDS KLLA0_B03608g 2897054 complement(329891..332185) B 1 NC_006038.1 similar to uniprot|P38888 Saccharomyces cerevisiae YHR204W MNL1 Alpha mannosidase-like protein of the endoplasmic reticulum required for degradation of glycoproteins but not for processing of N-linked oligosaccharides; alpha-1,2-mannosidase MNL1 332185 2897054 KLLA0_B03608g Kluyveromyces lactis alpha-1,2-mannosidase MNL1 XP_451695.1 329891 R 28985 CDS KLLA0_B03652g 2897114 join(332993..333006,333444..334215) B 1 NC_006038.1 highly similar to uniprot|P05753 Saccharomyces cerevisiae YJR145C RPS4A or to YHR203C uniprot|P05753 Saccharomyces cerevisiae YHR203C RPS4B; 40S ribosomal protein eS4 334215 2897114 KLLA0_B03652g Kluyveromyces lactis 40S ribosomal protein eS4 XP_451697.1 332993 D 28985 CDS KLLA0_B03674g 2897130 complement(334364..336277) B 1 NC_006038.1 similar to uniprot|P38887 Saccharomyces cerevisiae YHR202W; uncharacterized protein 336277 2897130 KLLA0_B03674g Kluyveromyces lactis uncharacterized protein XP_451698.1 334364 R 28985 CDS KLLA0_B03718g 2897514 336976..337842 B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 337842 2897514 KLLA0_B03718g Kluyveromyces lactis uncharacterized protein XP_451699.1 336976 D 28985 CDS KLLA0_B03740g 2897086 complement(337996..338784) B 1 NC_006038.1 uniprot|Q00970 Kluyveromyces lactis KLLA0B03740g MGM101 Mitochondrial genome maintenance protein MGM101 mitochondrial precursor; uncharacterized protein 338784 2897086 KLLA0_B03740g Kluyveromyces lactis uncharacterized protein XP_451700.1 337996 R 28985 CDS KLLA0_B03762g 2897519 339424..341742 B 1 NC_006038.1 similar to uniprot|P46971 Saccharomyces cerevisiae YJR143C PMT4 Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase; dolichyl-phosphate-mannose-protein mannosyltransferase 341742 2897519 KLLA0_B03762g Kluyveromyces lactis dolichyl-phosphate-mannose-protein mannosyltransferase XP_451701.1 339424 D 28985 CDS KLLA0_B03784g 2897524 complement(341886..342914) B 1 NC_006038.1 similar to uniprot|P47173 Saccharomyces cerevisiae YJR142W; uncharacterized protein 342914 2897524 KLLA0_B03784g Kluyveromyces lactis uncharacterized protein XP_451702.1 341886 R 28985 CDS KLLA0_B03806g 2897525 343108..344259 B 1 NC_006038.1 similar to uniprot|P38698 Saccharomyces cerevisiae YHR201C PPX1 Exopolyphosphatase hydrolyzes inorganic polyphosphate (poly P) into Pi residues located in the cytosol plasma membrane and mitochondrial matrix; exopolyphosphatase 344259 2897525 KLLA0_B03806g Kluyveromyces lactis exopolyphosphatase XP_451703.1 343108 D 28985 CDS KLLA0_B03828g 2897529 complement(344307..345371) B 1 NC_006038.1 weakly similar to uniprot|P47172 Saccharomyces cerevisiae YJR141W essential protein; uncharacterized protein 345371 2897529 KLLA0_B03828g Kluyveromyces lactis uncharacterized protein XP_451704.1 344307 R 28985 CDS KLLA0_B03850g 2897527 345635..350590 B 1 NC_006038.1 similar to uniprot|P47171 Saccharomyces cerevisiae YJR140C HIR3 Transcriptional corepressor; uncharacterized protein 350590 2897527 KLLA0_B03850g Kluyveromyces lactis uncharacterized protein XP_451705.1 345635 D 28985 CDS KLLA0_B03872g 2897531 join(350966..350999,351127..352175) B 1 NC_006038.1 similar to uniprot|P31116 Saccharomyces cerevisiae YJR139C HOM6 Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions; homoserine dehydrogenase 352175 2897531 KLLA0_B03872g Kluyveromyces lactis homoserine dehydrogenase XP_451706.2 350966 D 28985 CDS KLLA0_B03894g 2897535 complement(352195..356871) B 1 NC_006038.1 similar to uniprot|P47170 Saccharomyces cerevisiae YJR138W IML1; GTPase-activating protein IML1 356871 2897535 KLLA0_B03894g Kluyveromyces lactis GTPase-activating protein IML1 XP_451707.1 352195 R 28985 CDS KLLA0_B03916g 2897522 complement(357312..358055) B 1 NC_006038.1 similar to uniprot|P38886 Saccharomyces cerevisiae YHR200W RPN10 Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; proteasome regulatory particle base subunit RPN10 358055 2897522 KLLA0_B03916g Kluyveromyces lactis proteasome regulatory particle base subunit RPN10 XP_451708.1 357312 R 28985 CDS KLLA0_B03927g 9487357 358538..358786 B 1 NC_006038.1 no similarity; uncharacterized protein 358786 9487357 KLLA0_B03927g Kluyveromyces lactis uncharacterized protein XP_002999353.1 358538 D 28985 CDS KLLA0_B03938g 2897189 359757..363440 B 1 NC_006038.1 similar to sp|P47169 Saccharomyces cerevisiae YJR137c ECM17 Sulfite reductase [NADPH] beta subunit involved in amino acid biosynthesis transcription repressed by methionine; sulfite reductase (NADPH) subunit beta 363440 2897189 KLLA0_B03938g Kluyveromyces lactis sulfite reductase (NADPH) subunit beta XP_451709.1 359757 D 28985 CDS KLLA0_B03982g 2897270 364575..365522 B 1 NC_006038.1 similar to uniprot|P38884 Saccharomyces cerevisiae YHR198C FMP22 The authentic non-tagged protein was localized to the mitochondria; uncharacterized protein 365522 2897270 KLLA0_B03982g Kluyveromyces lactis uncharacterized protein XP_451711.1 364575 D 28985 CDS KLLA0_B04004g 2897313 complement(365687..367903) B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 367903 2897313 KLLA0_B04004g Kluyveromyces lactis uncharacterized protein XP_451712.1 365687 R 28985 CDS KLLA0_B04026g 2897541 368180..369463 B 1 NC_006038.1 similar to uniprot|P47168 Saccharomyces cerevisiae YJR136C; uncharacterized protein 369463 2897541 KLLA0_B04026g Kluyveromyces lactis uncharacterized protein XP_451713.1 368180 D 28985 CDS KLLA0_B04048g 2897544 complement(369643..369906) B 1 NC_006038.1 highly similar to uniprot|P57744 Saccharomyces cerevisiae YJR135W-A TIM8 Mitochondrial intermembrane space import protein; protein transporter TIM8 369906 2897544 KLLA0_B04048g Kluyveromyces lactis protein transporter TIM8 XP_451714.1 369643 R 28985 CDS KLLA0_B04070g 2897539 370262..370951 B 1 NC_006038.1 weakly similar to uniprot|P47167 Saccharomyces cerevisiae YJR135C MCM22 Protein involved in minichromosome maintenance; uncharacterized protein 370951 2897539 KLLA0_B04070g Kluyveromyces lactis uncharacterized protein XP_451715.1 370262 D 28985 CDS KLLA0_B04092g 2897546 complement(370977..373307) B 1 NC_006038.1 similar to uniprot|P38883 Saccharomyces cerevisiae YHR197W RIX1 RIbosome eXport essential protein; uncharacterized protein 373307 2897546 KLLA0_B04092g Kluyveromyces lactis uncharacterized protein XP_451716.1 370977 R 28985 CDS KLLA0_B04136g 2897330 373969..375975 B 1 NC_006038.1 similar to uniprot|P47166 Saccharomyces cerevisiae YJR134C SGM1 Protein of unknown function required for wild-type growth rate on galactose and mannose localizes to COPI coated vesicles and the Golgi apparatus; uncharacterized protein 375975 2897330 KLLA0_B04136g Kluyveromyces lactis uncharacterized protein XP_451717.1 373969 D 28985 CDS KLLA0_B04158g 2897399 complement(376098..376745) B 1 NC_006038.1 highly similar to uniprot|P47165 Saccharomyces cerevisiae YJR133W XPT1 Xanthine Phosphoribosyl Transferase; xanthine phosphoribosyltransferase 376745 2897399 KLLA0_B04158g Kluyveromyces lactis xanthine phosphoribosyltransferase XP_451718.1 376098 R 28985 CDS KLLA0_B04180g 2897549 complement(377179..378798) B 1 NC_006038.1 similar to uniprot|P38882 Saccharomyces cerevisiae YHR196W UTP9 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; uncharacterized protein 378798 2897549 KLLA0_B04180g Kluyveromyces lactis uncharacterized protein XP_451719.1 377179 R 28985 CDS KLLA0_B04202g 2897550 complement(379105..382263) B 1 NC_006038.1 similar to uniprot|P46970 Saccharomyces cerevisiae YJR132W NMD5 Karyopherin a carrier protein involved in nuclear import of proteins importin beta homolog; uncharacterized protein 382263 2897550 KLLA0_B04202g Kluyveromyces lactis uncharacterized protein XP_451720.1 379105 R 28985 CDS KLLA0_B04224g 2897423 complement(382676..383515) B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 383515 2897423 KLLA0_B04224g Kluyveromyces lactis uncharacterized protein XP_451721.1 382676 R 28985 CDS KLLA0_B04246g 2897426 complement(383847..385640) B 1 NC_006038.1 similar to uniprot|P38880 Saccharomyces cerevisiae YHR194W MDM31 Mitochondrial Distribution and Morphology; uncharacterized protein 385640 2897426 KLLA0_B04246g Kluyveromyces lactis uncharacterized protein XP_451722.1 383847 R 28985 CDS KLLA0_B04290g 2896918 386351..386881 B 1 NC_006038.1 similar to uniprot|P38879 Saccharomyces cerevisiae YHR193C EGD2 Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation associated with cytoplasmic ribosomes; uncharacterized protein 386881 2896918 KLLA0_B04290g Kluyveromyces lactis uncharacterized protein XP_451723.1 386351 D 28985 CDS KLLA0_B04312g 2897465 complement(386963..387796) B 1 NC_006038.1 similar to uniprot|P38878 Saccharomyces cerevisiae YHR192W; uncharacterized protein 387796 2897465 KLLA0_B04312g Kluyveromyces lactis uncharacterized protein XP_451724.1 386963 R 28985 CDS KLLA0_B04334g 2897431 388079..388480 B 1 NC_006038.1 similar to uniprot|P38877 Saccharomyces cerevisiae YHR191C CTF8 Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; uncharacterized protein 388480 2897431 KLLA0_B04334g Kluyveromyces lactis uncharacterized protein XP_451725.1 388079 D 28985 CDS KLLA0_B04356g 2897260 complement(388545..390200) B 1 NC_006038.1 similar to uniprot|P32906 Saccharomyces cerevisiae YJR131W MNS1 Alpha-1 2-mannosidase involved in N-linked oligosaccharide biosynthesis catalyzes the removal of one mannose residue from Man9GlcNAc to produce a single isomer of Man8GlcNAc integral to the ER membrane; mannosyl-oligosaccharide 1,2-alpha-mannosidase 390200 2897260 KLLA0_B04356g Kluyveromyces lactis mannosyl-oligosaccharide 1,2-alpha-mannosidase XP_451726.1 388545 R 28985 CDS KLLA0_B04378g 2897308 390701..392767 B 1 NC_006038.1 similar to uniprot|P47164 Saccharomyces cerevisiae YJR130C STR2 Cystathionine gamma-synthase converts cysteine into cystathionine; cystathionine gamma-synthase 392767 2897308 KLLA0_B04378g Kluyveromyces lactis cystathionine gamma-synthase XP_451727.1 390701 D 28985 CDS KLLA0_B04400g 2897292 complement(393246..393422) B 1 NC_006038.1 similar to uniprot|P81450 Saccharomyces cerevisiae YML081C-A ATP18 Subunit of the mitochondrial F1F0 ATP synthase; F1F0 ATP synthase subunit i 393422 2897292 KLLA0_B04400g Kluyveromyces lactis F1F0 ATP synthase subunit i XP_451728.1 393246 R 28985 CDS KLLA0_B04422g 2897236 394524..395585 B 1 NC_006038.1 similar to uniprot|P25335 Saccharomyces cerevisiae YIR029W DAL2 Allantoicase; allantoicase 395585 2897236 KLLA0_B04422g Kluyveromyces lactis allantoicase XP_451729.1 394524 D 28985 CDS KLLA0_B04444g 2897366 395811..396737 B 1 NC_006038.1 similar to uniprot|P47163 Saccharomyces cerevisiae YJR129C Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; protein-lysine N-methyltransferase 396737 2897366 KLLA0_B04444g Kluyveromyces lactis protein-lysine N-methyltransferase XP_451730.1 395811 D 28985 CDS KLLA0_B04455g 2897388 396805..397698 B 1 NC_006038.1 no similarity; uncharacterized protein 397698 2897388 KLLA0_B04455g Kluyveromyces lactis uncharacterized protein XP_451731.1 396805 D 28985 CDS KLLA0_B04466g 9487275 398179..398415 B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 398415 9487275 KLLA0_B04466g Kluyveromyces lactis uncharacterized protein XP_002999354.1 398179 D 28985 CDS KLLA0_B04477g 2896893 400019..404017 B 1 NC_006038.1 similar to uniprot|Q04545 Saccharomyces cerevisiae YML081W; uncharacterized protein 404017 2896893 KLLA0_B04477g Kluyveromyces lactis uncharacterized protein XP_451732.1 400019 D 28985 CDS KLLA0_B04499g 2896904 404546..405823 B 1 NC_006038.1 similar to uniprot|P53759 Saccharomyces cerevisiae YML080W DUS1 Dihydrouridine synthase member of a widespread family of conserved proteins including Smm1p Dus3p and Dus4p modifies pre-tRNA(Phe) at U17; tRNA dihydrouridine synthase 405823 2896904 KLLA0_B04499g Kluyveromyces lactis tRNA dihydrouridine synthase XP_451733.1 404546 D 28985 CDS KLLA0_B04521g 2896957 406174..406806 B 1 NC_006038.1 similar to uniprot|Q03629 Saccharomyces cerevisiae YML079W Uncharacterized protein with structural resemblance to plant storage and ligand binding proteins (canavalin glycinin auxin binding protein) and also to some plant and bacterial enzymes (epimerase germin); uncharacterized protein 406806 2896957 KLLA0_B04521g Kluyveromyces lactis uncharacterized protein XP_451734.1 406174 D 28985 CDS KLLA0_B04543g 2896932 407088..409415 B 1 NC_006038.1 similar to uniprot|P47161 Saccharomyces cerevisiae YJR126C VPS70; uncharacterized protein 409415 2896932 KLLA0_B04543g Kluyveromyces lactis uncharacterized protein XP_451735.1 407088 D 28985 CDS KLLA0_B04565g 2896995 409720..410298 B 1 NC_006038.1 highly similar to uniprot|P25719 Saccharomyces cerevisiae YML078W CPR3 Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues involved in protein refolding after import into mitochondria; peptidylprolyl isomerase CPR3 410298 2896995 KLLA0_B04565g Kluyveromyces lactis peptidylprolyl isomerase CPR3 XP_451736.1 409720 D 28985 CDS KLLA0_B04587g 2896962 411097..412299 B 1 NC_006038.1 similar to uniprot|P47160 Saccharomyces cerevisiae YJR125C ENT3 Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes associates with the clathrin adaptor Gga2p; uncharacterized protein 412299 2896962 KLLA0_B04587g Kluyveromyces lactis uncharacterized protein XP_451737.1 411097 D 28985 CDS KLLA0_B04609g 2897164 join(412600..412633,412731..413134) B 1 NC_006038.1 similar to uniprot|Q03630 Saccharomyces cerevisiae YML077w BET5 involved in targeting and fusion of ER to golgi transport vesicles singleton; TRAPP subunit BET5 413134 2897164 KLLA0_B04609g Kluyveromyces lactis TRAPP subunit BET5 XP_451738.2 412600 D 28985 CDS KLLA0_B04620g 2897122 complement(413129..415888) B 1 NC_006038.1 similar to uniprot|Q03631 Saccharomyces cerevisiae YML076C WAR1 zinc finger transcription factor; uncharacterized protein 415888 2897122 KLLA0_B04620g Kluyveromyces lactis uncharacterized protein XP_451739.1 413129 R 28985 CDS KLLA0_B04642g 2897193 complement(417088..420306) B 1 NC_006038.1 similar to uniprot|P12683 Saccharomyces cerevisiae YML075C HMG1 One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate which is a rate-limiting step in sterol biosynthesis localizes to the nuclear envelope overproduction induces the formation of karmellae; hydroxymethylglutaryl-CoA reductase (NADPH) HMG1 420306 2897193 KLLA0_B04642g Kluyveromyces lactis hydroxymethylglutaryl-CoA reductase (NADPH) HMG1 XP_451740.1 417088 R 28985 CDS KLLA0_B04664g 2897200 complement(421574..422830) B 1 NC_006038.1 highly similar to uniprot|Q06205 Saccharomyces cerevisiae and to YML074c uniprot|P38911 Saccharomyces cerevisiae; peptidylprolyl isomerase FPR3 422830 2897200 KLLA0_B04664g Kluyveromyces lactis peptidylprolyl isomerase FPR3 XP_451741.1 421574 R 28985 CDS KLLA0_B04686g 2897480 complement(join(423406..423924,424612..424620)) B 1 NC_006038.1 highly similar to uniprot|P05739 Saccharomyces cerevisiae YLR448W; 60S ribosomal protein eL6 424620 2897480 KLLA0_B04686g Kluyveromyces lactis 60S ribosomal protein eL6 XP_451742.1 423406 R 28985 CDS KLLA0_B04708g 2896913 complement(425404..429876) B 1 NC_006038.1 similar to uniprot|Q03640 Saccharomyces cerevisiae YML072C TCB3 Contains three calcium and lipid binding domains localized to the bud green fluorescent protein (GFP)-fusion protein localizes to the cell periphery mRNA is targeted to the bud via the mRNA transport system involving She2p C-terminal portion of Tcb1p Tcb2p and Tcb3p interact; uncharacterized protein 429876 2896913 KLLA0_B04708g Kluyveromyces lactis uncharacterized protein XP_451743.1 425404 R 28985 CDS KLLA0_B04730g 2896878 complement(430341..431597) B 1 NC_006038.1 similar to uniprot|Q04632 Saccharomyces cerevisiae YML071C COG8 Component of the conserved oligomeric Golgi complex; Golgi transport complex subunit COG8 431597 2896878 KLLA0_B04730g Kluyveromyces lactis Golgi transport complex subunit COG8 XP_451744.1 430341 R 28985 CDS KLLA0_B04752g 2897101 432210..433253 B 1 NC_006038.1 highly similar to uniprot|P32366 Saccharomyces cerevisiae YLR447C VMA6 vacuolar ATPase V0 domain subunit d; H(+)-transporting V0 sector ATPase subunit d 433253 2897101 KLLA0_B04752g Kluyveromyces lactis H(+)-transporting V0 sector ATPase subunit d XP_451745.1 432210 D 28985 CDS KLLA0_B04774g 2897058 complement(433472..436759) B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 436759 2897058 KLLA0_B04774g Kluyveromyces lactis uncharacterized protein XP_451746.1 433472 R 28985 CDS KLLA0_B04796g 2897139 438316..438900 B 1 NC_006038.1 some similarities with uniprot|Q12091 Saccharomyces cerevisiae YPL170W DAP1 Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p damage response protein related to mammalian membrane progesterone receptors mutations lead to defects in telomeres mitochondria and sterol synthesis; uncharacterized protein 438900 2897139 KLLA0_B04796g Kluyveromyces lactis uncharacterized protein XP_451747.1 438316 D 28985 CDS KLLA0_B04818g 2897117 complement(438908..439402) B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 439402 2897117 KLLA0_B04818g Kluyveromyces lactis uncharacterized protein XP_451748.1 438908 R 28985 CDS KLLA0_B04840g 2897181 439864..442179 B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 442179 2897181 KLLA0_B04840g Kluyveromyces lactis uncharacterized protein XP_451749.1 439864 D 28985 CDS KLLA0_B04862g 2897190 442398..443591 B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 443591 2897190 KLLA0_B04862g Kluyveromyces lactis uncharacterized protein XP_451750.1 442398 D 28985 CDS KLLA0_B04884g 2897201 443932..445689 B 1 NC_006038.1 highly similar to uniprot|P54838 Saccharomyces cerevisiae YML070W DAK1 Dihydroxyacetone kinase required for detoxification of dihydroxyacetone (DHA) involved in stress adaptation; dihydroxyacetone kinase 445689 2897201 KLLA0_B04884g Kluyveromyces lactis dihydroxyacetone kinase XP_451751.1 443932 D 28985 CDS KLLA0_B04906g 2897209 446132..447799 B 1 NC_006038.1 highly similar to uniprot|Q04636 Saccharomyces cerevisiae YML069W POB3 facilitates RNA Polymerase II transcription elongation; FACT complex subunit POB3 447799 2897209 KLLA0_B04906g Kluyveromyces lactis FACT complex subunit POB3 XP_451752.1 446132 D 28985 CDS KLLA0_B04928g 2897220 complement(449470..450006) B 1 NC_006038.1 some similarities with uniprot|Q06201 Saccharomyces cerevisiae YLR445W Hypothetical ORF; uncharacterized protein 450006 2897220 KLLA0_B04928g Kluyveromyces lactis uncharacterized protein XP_451753.1 449470 R 28985 CDS KLLA0_B04950g 2897238 complement(join(450251..451245,451367..451397)) B 1 NC_006038.1 similar to uniprot|Q04651 Saccharomyces cerevisiae YML067C ERV41 Protein in COPII-coated vesicles; uncharacterized protein 451397 2897238 KLLA0_B04950g Kluyveromyces lactis uncharacterized protein XP_451754.1 450251 R 28985 CDS KLLA0_B04972g 2897240 complement(451695..452831) B 1 NC_006038.1 weakly similar to uniprot|Q04658 Saccharomyces cerevisiae YML066C SMA2 Spore Membrane Assembly; uncharacterized protein 452831 2897240 KLLA0_B04972g Kluyveromyces lactis uncharacterized protein XP_451755.1 451695 R 28985 CDS KLLA0_B04994g 2897254 complement(453048..454244) B 1 NC_006038.1 similar to uniprot|Q2VQX1 Saccharomyces cerevisiae YLR443W ECM7; uncharacterized protein 454244 2897254 KLLA0_B04994g Kluyveromyces lactis uncharacterized protein XP_451756.1 453048 R 28985 CDS KLLA0_B05016g 2897110 454717..457377 B 1 NC_006038.1 uniprot|P54788 Kluyveromyces lactis KLLA0B05016g ORC1 Origin recognition complex subunit 1; origin recognition complex subunit 1 457377 2897110 KLLA0_B05016g Kluyveromyces lactis origin recognition complex subunit 1 XP_451757.1 454717 D 28985 CDS KLLA0_B05038g 2897262 complement(457608..458279) B 1 NC_006038.1 similar to uniprot|P38987 Saccharomyces cerevisiae YML064C TEM1 Gtp-binding protein of the ras superfamily involved in termination of M-phase GTP-binding protein RAS superfamily; Ras family GTPase TEM1 458279 2897262 KLLA0_B05038g Kluyveromyces lactis Ras family GTPase TEM1 XP_451758.1 457608 R 28985 CDS KLLA0_B05060g 2897271 459171..459938 B 1 NC_006038.1 highly similar to uniprot|P23248 Saccharomyces cerevisiae RPS1B and uniprot|P33442 Saccharomyces cerevisiae YLR441C RPS1A Ribosomal protein 10 (rp10) of the small (40S) subunit; 40S ribosomal protein eS1 459938 2897271 KLLA0_B05060g Kluyveromyces lactis 40S ribosomal protein eS1 XP_451759.1 459171 D 28985 CDS KLLA0_B05082g 2897273 complement(460262..461326) B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 461326 2897273 KLLA0_B05082g Kluyveromyces lactis uncharacterized protein XP_451760.1 460262 R 28985 CDS KLLA0_B05115g 2897289 461624..463642 B 1 NC_006038.1 similar to uniprot|Q7LHI0 Saccharomyces cerevisiae YLR440C SEC39 Protein of unknown function proposed to be involved in protein secretion; uncharacterized protein 463642 2897289 KLLA0_B05115g Kluyveromyces lactis uncharacterized protein XP_451762.1 461624 D 28985 CDS KLLA0_B05137g 2897298 complement(463716..466334) B 1 NC_006038.1 similar to uniprot|P07271 Saccharomyces cerevisiae YML061C PIF1 DNA helicase involved in telomere formation and elongation acts as a catalytic inhibitor of telomerase also plays a role in repair and recombination of mitochondrial DNA; DNA helicase PIF1 466334 2897298 KLLA0_B05137g Kluyveromyces lactis DNA helicase PIF1 XP_451763.1 463716 R 28985 CDS KLLA0_B05159g 2897310 466882..468075 B 1 NC_006038.1 similar to uniprot|P53397 Saccharomyces cerevisiae YML060W OGG1 Mitochondrial glycosylase/lyase that specifically excises 7 8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA repairs oxidative damage to mitochondrial DNA; 8-oxoguanine glycosylase OGG1 468075 2897310 KLLA0_B05159g Kluyveromyces lactis 8-oxoguanine glycosylase OGG1 XP_451764.1 466882 D 28985 CDS KLLA0_B05181g 2897425 complement(468267..469265) B 1 NC_006038.1 similar to uniprot|P36517 Saccharomyces cerevisiae YLR439W MRPL4 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein uL29m 469265 2897425 KLLA0_B05181g Kluyveromyces lactis mitochondrial 54S ribosomal protein uL29m XP_451765.1 468267 R 28985 CDS KLLA0_B05203g 2897484 469929..470180 B 1 NC_006038.1 similar to uniprot|P57743 Saccharomyces cerevisiae YLR438C-A LSM3 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay; U4/U6-U5 snRNP complex subunit LSM3 470180 2897484 KLLA0_B05203g Kluyveromyces lactis U4/U6-U5 snRNP complex subunit LSM3 XP_451766.1 469929 D 28985 CDS KLLA0_B05225g 2896879 complement(470465..474790) B 1 NC_006038.1 similar to uniprot|Q04958 Saccharomyces cerevisiae YML059C NTE1 Serine esterase that deacylates exogenous lysophospholipids homolog of human neuropathy target esterase (NTE) mammalian NTE1 deacylates phosphatidylcholine to glycerophosphocholine; lysophospholipase 474790 2896879 KLLA0_B05225g Kluyveromyces lactis lysophospholipase XP_451767.1 470465 R 28985 CDS KLLA0_B05247g 2896939 complement(475265..476578) B 1 NC_006038.1 highly similar to uniprot|P07991 Saccharomyces cerevisiae YLR438W CAR2 L-ornithine transaminase (OTAse) catalyzes the second step of arginine degradation expression is dually-regulated by allophanate induction and a specific arginine induction process not nitrogen catabolite repression sensitive; ornithine-oxo-acid transaminase 476578 2896939 KLLA0_B05247g Kluyveromyces lactis ornithine-oxo-acid transaminase XP_451768.1 475265 R 28985 CDS KLLA0_B05269g 2896997 477175..477609 B 1 NC_006038.1 similar to uniprot|Q6HIN8 Bacillus thuringiensis subsp BT9727_2262 Hypothetical protein; uncharacterized protein 477609 2896997 KLLA0_B05269g Kluyveromyces lactis uncharacterized protein XP_451769.1 477175 D 28985 CDS KLLA0_B05379g 2897226 482011..482346 B 1 NC_006038.1 no similarity; uncharacterized protein 482346 2897226 KLLA0_B05379g Kluyveromyces lactis uncharacterized protein XP_451775.1 482011 D 28985 CDS KLLA0_B05423g 2897253 483167..483643 B 1 NC_006038.1 weakly similar to uniprot|O13577 Saccharomyces cerevisiae YLR437C; uncharacterized protein 483643 2897253 KLLA0_B05423g Kluyveromyces lactis uncharacterized protein XP_451777.1 483167 D 28985 CDS KLLA0_B05445g 2897285 484297..487248 B 1 NC_006038.1 some similarities with uniprot|Q06673 Saccharomyces cerevisiae YLR436C ECM30 Non-essential protein of unknown function; uncharacterized protein 487248 2897285 KLLA0_B05445g Kluyveromyces lactis uncharacterized protein XP_451778.1 484297 D 28985 CDS KLLA0_B05467g 2897306 complement(487353..487982) B 1 NC_006038.1 similar to uniprot|Q06672 Saccharomyces cerevisiae YLR435W TSR2 Protein with a potential role in pre-rRNA processing; uncharacterized protein 487982 2897306 KLLA0_B05467g Kluyveromyces lactis uncharacterized protein XP_451779.1 487353 R 28985 CDS KLLA0_B05489g 2897312 488386..490023 B 1 NC_006038.1 similar to uniprot|P14747 Saccharomyces cerevisiae YML057W CMP2 calmodulin binding protein and to YLR433C uniprot|P23287 Saccharomyces cerevisiae YLR433C CNA1 calmodulin binding protein; calcineurin catalytic subunit A 490023 2897312 KLLA0_B05489g Kluyveromyces lactis calcineurin catalytic subunit A XP_451780.1 488386 D 28985 CDS KLLA0_B05511g 2897372 complement(join(490221..491335,491701..492157)) B 1 NC_006038.1 highly similar to uniprot|P50094 Saccharomyces cerevisiae IMD4 or to YLR432W uniprot|P50095 Saccharomyces cerevisiae IMD3 or to YHR216W uniprot|P38697 Saccharomyces cerevisiae IMD2, Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation; IMP dehydrogenase IMD3 492157 2897372 KLLA0_B05511g Kluyveromyces lactis IMP dehydrogenase IMD3 XP_451781.1 490221 R 28985 CDS KLLA0_B05533g 2897432 493517..494797 B 1 NC_006038.1 weakly similar to uniprot|Q06671 Saccharomyces cerevisiae YLR431C ATG23 Peripheral membrane protein required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway; uncharacterized protein 494797 2897432 KLLA0_B05533g Kluyveromyces lactis uncharacterized protein XP_451782.1 493517 D 28985 CDS KLLA0_B05555g 2897487 complement(494997..500990) B 1 NC_006038.1 similar to uniprot|Q00416 Saccharomyces cerevisiae YLR430W SEN1 Nuclear protein putative helicase required for processing of tRNAs rRNAs and small nuclear RNAs potential Cdc28p substrate; DNA/RNA helicase SEN1 500990 2897487 KLLA0_B05555g Kluyveromyces lactis DNA/RNA helicase SEN1 XP_451783.1 494997 R 28985 CDS KLLA0_B05577g 2896961 complement(501690..505355) B 1 NC_006038.1 highly similar to uniprot|P08518 Saccharomyces cerevisiae YOR151C; DNA-directed RNA polymerase II subunit RPB2 505355 2896961 KLLA0_B05577g Kluyveromyces lactis DNA-directed RNA polymerase II subunit RPB2 XP_451784.1 501690 R 28985 CDS KLLA0_B05599g 2897498 506136..506861 B 1 NC_006038.1 similar to uniprot|P32387 Saccharomyces cerevisiae YDR405W MRP20 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein uL23m 506861 2897498 KLLA0_B05599g Kluyveromyces lactis mitochondrial 54S ribosomal protein uL23m XP_451785.1 506136 D 28985 CDS KLLA0_B05621g 2897072 complement(507613..508227) B 1 NC_006038.1 similar to uniprot|P53224 Saccharomyces cerevisiae YGR038W; sphingolipid homeostasis protein ORM2 508227 2897072 KLLA0_B05621g Kluyveromyces lactis sphingolipid homeostasis protein ORM2 XP_451786.1 507613 R 28985 CDS KLLA0_B05643g 2897064 join(509019..509045,509123..509359) B 1 NC_006038.1 highly similar to uniprot|P31787 Saccharomyces cerevisiae YGR037C ACB1 Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; long-chain fatty acid transporter ACB1 509359 2897064 KLLA0_B05643g Kluyveromyces lactis long-chain fatty acid transporter ACB1 XP_451787.2 509019 D 28985 CDS KLLA0_B05665g 2897126 510167..512752 B 1 NC_006038.1 highly similar to uniprot|Q06142 Saccharomyces cerevisiae YLR347C KAP95 Karyopherin beta forms a dimeric complex with Srp1p (Kap60p) that mediates nuclear import of cargo proteins via a nuclear localization signal (NLS) interacts with nucleoporins to guide transport across the nuclear pore complex; karyopherin beta 512752 2897126 KLLA0_B05665g Kluyveromyces lactis karyopherin beta XP_451788.1 510167 D 28985 CDS KLLA0_B05687g 2897205 513579..514274 B 1 NC_006038.1 similar to uniprot|P53223 Saccharomyces cerevisiae YGR036C CAX4 Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER cleaves the anhydride linkage in Dol-P-P required for Dol-P-P- linked oligosaccharide intermediate synthesis and protein N-glycosylation; dolichyldiphosphatase 514274 2897205 KLLA0_B05687g Kluyveromyces lactis dolichyldiphosphatase XP_451789.1 513579 D 28985 CDS KLLA0_B05709g 2897218 complement(514421..516064) B 1 NC_006038.1 similar to uniprot|Q06137 Saccharomyces cerevisiae YLR345W; bifunctional fructose-2,6-bisphosphate 2-phosphatase/6-phosphofructo-2-kinase 516064 2897218 KLLA0_B05709g Kluyveromyces lactis bifunctional fructose-2,6-bisphosphate 2-phosphatase/6-phosphofructo-2-kinase XP_451790.1 514421 R 28985 CDS KLLA0_B05742g 2897261 complement(join(516562..516926,517542..517560)) B 1 NC_006038.1 highly similar to uniprot|P05743 Saccharomyces cerevisiae YLR344W; 60S ribosomal protein uL24 517560 2897261 KLLA0_B05742g Kluyveromyces lactis 60S ribosomal protein uL24 XP_451792.1 516562 R 28985 CDS KLLA0_B05786g 2897309 519156..519860 B 1 NC_006038.1 similar to uniprot|P53220 Saccharomyces cerevisiae YGR033C FMP17 The authentic non-tagged protein was localized to the mitochondria; uncharacterized protein 519860 2897309 KLLA0_B05786g Kluyveromyces lactis uncharacterized protein XP_451793.1 519156 D 28985 CDS KLLA0_B05808g 2897360 complement(520133..521713) B 1 NC_006038.1 similar to uniprot|Q06135 Saccharomyces cerevisiae YLR343W GAS2 Putative 1,3-beta-glucanosyltransferase has similarity to Gas1p; 1,3-beta-glucanosyltransferase 521713 2897360 KLLA0_B05808g Kluyveromyces lactis 1,3-beta-glucanosyltransferase XP_451794.1 520133 R 28985 CDS KLLA0_B05841g 2897430 complement(522241..527877) B 1 NC_006038.1 highly similar to uniprot|P38631 Saccharomyces cerevisiae YLR342W FKS1 Catalytic subunit of 1 3-beta-D-glucan synthase functionally redundant with alternate catalytic subunit Gsc2p binds to regulatory subunit Rho1p involved in cell wall synthesis and maintenance localizes to sites of cell wall remodeling or uniprot|P40989 Saccharomyces cerevisiae YGR032W GSC2; 1,3-beta-D-glucan synthase 527877 2897430 KLLA0_B05841g Kluyveromyces lactis 1,3-beta-D-glucan synthase XP_451796.1 522241 R 28985 CDS KLLA0_B05863g 2897458 complement(529188..530222) B 1 NC_006038.1 similar to uniprot|P53219 Saccharomyces cerevisiae YGR031W; uncharacterized protein 530222 2897458 KLLA0_B05863g Kluyveromyces lactis uncharacterized protein XP_451797.1 529188 R 28985 CDS KLLA0_B05885g 2897471 complement(530762..532738) B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 532738 2897471 KLLA0_B05885g Kluyveromyces lactis uncharacterized protein XP_451798.1 530762 R 28985 CDS KLLA0_B05918g 2897010 complement(533071..534006) B 1 NC_006038.1 highly similar to uniprot|P05317 Saccharomyces cerevisiae YLR340W RPP0 Conserved ribosomal protein P0 similar to rat P0, human P0, and E. coli L10e; shown to be phosphorylated on serine 302; 60S ribosomal protein uL10 534006 2897010 KLLA0_B05918g Kluyveromyces lactis 60S ribosomal protein uL10 XP_451800.1 533071 R 28985 CDS KLLA0_B05973g 2897119 534679..535140 B 1 NC_006038.1 similar to uniprot|P53218 Saccharomyces cerevisiae YGR030C POP6 Subunit of both RNase MRP which cleaves pre-rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends; ribonuclease P/MRP protein subunit POP6 535140 2897119 KLLA0_B05973g Kluyveromyces lactis ribonuclease P/MRP protein subunit POP6 XP_451803.1 534679 D 28985 CDS KLLA0_B05995g 2897182 535752..537224 B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 537224 2897182 KLLA0_B05995g Kluyveromyces lactis uncharacterized protein XP_451804.1 535752 D 28985 CDS KLLA0_B06039g 2897245 538539..540308 B 1 NC_006038.1 some similarities with YLR337C uniprot|Q06133 Saccharomyces cerevisiae YLR337C VRP1 Involved in cytoskeletal organization and cellular growth Proline-rich protein verprolin; uncharacterized protein 540308 2897245 KLLA0_B06039g Kluyveromyces lactis uncharacterized protein XP_451805.1 538539 D 28985 CDS KLLA0_B06061g 2897268 complement(join(540386..540917,541004..541086)) B 1 NC_006038.1 similar to uniprot|P27882 Saccharomyces cerevisiae YGR029W ERV1 Flavin-linked sulfhydryl oxidase localized to the mitochondrial intermembrane space has a role in the maturation of cytosolic iron-sulfur proteins ortholog of human hepatopoietin (ALR); flavin-linked sulfhydryl oxidase 541086 2897268 KLLA0_B06061g Kluyveromyces lactis flavin-linked sulfhydryl oxidase XP_451806.2 540386 R 28985 CDS KLLA0_B06094g 2897359 complement(541408..542490) B 1 NC_006038.1 highly similar to uniprot|P28737 Saccharomyces cerevisiae YGR028W MSP1 Mitochondrial protein involved in sorting of proteins in the mitochondria putative membrane-spanning ATPase; uncharacterized protein 542490 2897359 KLLA0_B06094g Kluyveromyces lactis uncharacterized protein XP_451808.1 541408 R 28985 CDS KLLA0_B06116g 2897333 543019..546174 B 1 NC_006038.1 some similarities with uniprot|Q06132 Saccharomyces cerevisiae YLR336C SGD1 Suppressor of Glycerol Defect may be involved in high osmolarity signaling pathway; uncharacterized protein 546174 2897333 KLLA0_B06116g Kluyveromyces lactis uncharacterized protein XP_451809.1 543019 D 28985 CDS KLLA0_B06138g 2897551 complement(546274..548259) B 1 NC_006038.1 weakly similar to uniprot|P32499 Saccharomyces cerevisiae YLR335W NUP2 Protein involved in nucleocytoplasmic transport binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels also has a role in chromatin organization; nucleoporin NUP2 548259 2897551 KLLA0_B06138g Kluyveromyces lactis nucleoporin NUP2 XP_451810.1 546274 R 28985 CDS KLLA0_B06182g 2897005 549795..550121 B 1 NC_006038.1 similar to uniprot|Q3E792 Saccharomyces cerevisiae YGR027C; 40S ribosomal protein eS25 550121 2897005 KLLA0_B06182g Kluyveromyces lactis 40S ribosomal protein eS25 XP_451812.1 549795 D 28985 CDS KLLA0_B06215g 2897104 complement(551524..552330) B 1 NC_006038.1 similar to uniprot|P53217 Saccharomyces cerevisiae YGR026W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; uncharacterized protein 552330 2897104 KLLA0_B06215g Kluyveromyces lactis uncharacterized protein XP_451813.1 551524 R 28985 CDS KLLA0_B06237g 2897311 552909..553622 B 1 NC_006038.1 highly similar to uniprot|P53215 Saccharomyces cerevisiae YGR024C THG1 tRNAHis guanylyltransferase adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage essential enzyme conserved among eukaryotes; tRNA guanylyltransferase 553622 2897311 KLLA0_B06237g Kluyveromyces lactis tRNA guanylyltransferase XP_451814.1 552909 D 28985 CDS KLLA0_B06259g 2897331 complement(553658..554782) B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 554782 2897331 KLLA0_B06259g Kluyveromyces lactis uncharacterized protein XP_451815.1 553658 R 28985 CDS KLLA0_B06303g 2897446 complement(555780..559391) B 1 NC_006038.1 highly similar to uniprot|P22138 Saccharomyces cerevisiae YPR010C RPA135 RNA polymerase I subunit A135; DNA-directed RNA polymerase I core subunit RPA135 559391 2897446 KLLA0_B06303g Kluyveromyces lactis DNA-directed RNA polymerase I core subunit RPA135 XP_451816.1 555780 R 28985 CDS KLLA0_B06347g 2896919 561565..562311 B 1 NC_006038.1 some similarities with uniprot|P28319 Saccharomyces cerevisiae YKL096W CWP1 Cell wall mannoprotein linked to a beta-1 3- and beta-1 6-glucan heteropolymer through a phosphodiester bond involved in cell wall organization; uncharacterized protein 562311 2896919 KLLA0_B06347g Kluyveromyces lactis uncharacterized protein XP_451817.1 561565 D 28985 CDS KLLA0_B06369g 2896896 562846..563661 B 1 NC_006038.1 similar to uniprot|P28320 Saccharomyces cerevisiae YKL095W YJU2 Essential nuclear protein putative spliceosomal component involved in mRNA splicing based on computational analysis of large-scale protein-protein interaction data; mRNA splicing protein YJU2 563661 2896896 KLLA0_B06369g Kluyveromyces lactis mRNA splicing protein YJU2 XP_451818.1 562846 D 28985 CDS KLLA0_B06391g 2897011 563851..564816 B 1 NC_006038.1 similar to uniprot|P28321 Saccharomyces cerevisiae YKL094W YJU3 Protein of unknown function localizes to lipid particles; acylglycerol lipase 564816 2897011 KLLA0_B06391g Kluyveromyces lactis acylglycerol lipase XP_451819.1 563851 D 28985 CDS KLLA0_B06413g 2896948 566429..567424 B 1 NC_006038.1 weakly similar to uniprot|P23493 Saccharomyces cerevisiae YKL093W MBR1 Protein involved in mitochondrial functions and stress response; uncharacterized protein 567424 2896948 KLLA0_B06413g Kluyveromyces lactis uncharacterized protein XP_451820.1 566429 D 28985 CDS KLLA0_B06435g 2897490 567908..570817 B 1 NC_006038.1 similar to uniprot|P30771 Saccharomyces cerevisiae YMR080C NAM7 ATP-dependent RNA helicase of the SFI superfamily required for nonsense mediated mRNA decay and for efficient translation termination at nonsense codons; ATP-dependent RNA helicase NAM7 570817 2897490 KLLA0_B06435g Kluyveromyces lactis ATP-dependent RNA helicase NAM7 XP_451821.1 567908 D 28985 CDS KLLA0_B06457g 2897033 complement(570933..574073) B 1 NC_006038.1 similar to uniprot|P33314 Saccharomyces cerevisiae YKL092C BUD2 GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns mutants exhibit random budding in all cell types; GTPase-activating protein BUD2 574073 2897033 KLLA0_B06457g Kluyveromyces lactis GTPase-activating protein BUD2 XP_451822.1 570933 R 28985 CDS KLLA0_B06479g 2896969 complement(575030..575935) B 1 NC_006038.1 uniprot|P24859 Kluyveromyces lactis KLLA0B06479g SEC14 SEC14 cytosolic factor; phosphatidylinositol/phosphatidylcholine-binding protein 575935 2896969 KLLA0_B06479g Kluyveromyces lactis phosphatidylinositol/phosphatidylcholine-binding protein XP_451823.1 575030 R 28985 CDS KLLA0_B06501g 2897116 complement(576636..579089) B 1 NC_006038.1 similar to uniprot|P47116 Saccharomyces cerevisiae YJR059W PTK2 Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane enhances spermine uptake; protein kinase PTK2 579089 2897116 KLLA0_B06501g Kluyveromyces lactis protein kinase PTK2 XP_451824.1 576636 R 28985 CDS KLLA0_B06523g 2897135 complement(579869..582862) B 1 NC_006038.1 similar to uniprot|P24004 Saccharomyces cerevisiae YKL197C PEX1 AAA-family ATPase peroxin required for peroxisome biogenesis contains two 230 amino acid ATP-binding AAA cassettes upregulated in anaerobiosis Pex1p and Pex6p interact via their N-terminal AAA-cassettes; AAA family ATPase peroxin 1 582862 2897135 KLLA0_B06523g Kluyveromyces lactis AAA family ATPase peroxin 1 XP_451825.1 579869 R 28985 CDS KLLA0_B06545g 2897232 583095..583541 B 1 NC_006038.1 highly similar to uniprot|Q00381 Saccharomyces cerevisiae YJR058C APS2 Small subunit of the clathrin-associated adaptor complex AP-2 which is involved in protein sorting at the plasma membrane related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex; uncharacterized protein 583541 2897232 KLLA0_B06545g Kluyveromyces lactis uncharacterized protein XP_451826.1 583095 D 28985 CDS KLLA0_B06556g 2897274 complement(583538..584164) B 1 NC_006038.1 similar to uniprot|P00572 Saccharomyces cerevisiae YJR057W CDC8 Thymidylate and uridylate kinase functions in de novo biosynthesis of pyrimidine deoxyribonucleotides converts dTMP to dTDP and dUMP to dUTP essential for mitotic and meiotic DNA replication homologous to S. pombe Tmp1p; bifunctional thymidylate/uridylate kinase 584164 2897274 KLLA0_B06556g Kluyveromyces lactis bifunctional thymidylate/uridylate kinase XP_451827.1 583538 R 28985 CDS KLLA0_B06622g 2896864 584889..586415 B 1 NC_006038.1 uniprot|Q7Z8M5 Kluyveromyces lactis CDC14; phosphoprotein phosphatase CDC14 586415 2896864 KLLA0_B06622g Kluyveromyces lactis phosphoprotein phosphatase CDC14 XP_451828.1 584889 D 28985 CDS KLLA0_B06644g 2896862 complement(586591..587406) B 1 NC_006038.1 similar to uniprot|P43605 Saccharomyces cerevisiae YFR027W ECO1 Acetyltransferase required for the establishment of sister chromatid cohesion during DNA replication but not for its maintenance during G2 and M phases also required for postreplicative double-strand break repair interacts with Chl1p; uncharacterized protein 587406 2896862 KLLA0_B06644g Kluyveromyces lactis uncharacterized protein XP_451829.1 586591 R 28985 CDS KLLA0_B06710g 2896869 588821..589450 B 1 NC_006038.1 similar to uniprot|Q12084 Saccharomyces cerevisiae YDR020C; uncharacterized protein 589450 2896869 KLLA0_B06710g Kluyveromyces lactis uncharacterized protein XP_451831.1 588821 D 28985 CDS KLLA0_B06732g 2896880 589699..591504 B 1 NC_006038.1 similar to uniprot|P38228 Saccharomyces cerevisiae YBR044C TCM62 mitochondrial protein (putative) chaperone; uncharacterized protein 591504 2896880 KLLA0_B06732g Kluyveromyces lactis uncharacterized protein XP_451832.1 589699 D 28985 CDS KLLA0_B06754g 2896877 592003..593184 B 1 NC_006038.1 similar to YDR019C, uniprot|P48015 Saccharomyces cerevisiae YDR019C (GCV1); glycine decarboxylase subunit T 593184 2896877 KLLA0_B06754g Kluyveromyces lactis glycine decarboxylase subunit T XP_451833.1 592003 D 28985 CDS KLLA0_B06776g 2896885 594172..595938 B 1 NC_006038.1 similar to uniprot|Q7LGU1 Saccharomyces cerevisiae YPL274W SAM3 High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p; bifunctional polyamine/amino acid permease SAM3 595938 2896885 KLLA0_B06776g Kluyveromyces lactis bifunctional polyamine/amino acid permease SAM3 XP_451834.1 594172 D 28985 CDS KLLA0_B06798g 2896955 596500..598491 B 1 NC_006038.1 similar to uniprot|P38227 Saccharomyces cerevisiae YBR043C QDR3 Multidrug transporter required for resistance to quinidine barban cisplatin and bleomycin member of the major facilitator superfamily of transporters conferring multiple drug resistance (MFS-MDR); uncharacterized protein 598491 2896955 KLLA0_B06798g Kluyveromyces lactis uncharacterized protein XP_451835.1 596500 D 28985 CDS KLLA0_B06820g 2896924 598869..600083 B 1 NC_006038.1 similar to uniprot|P38226 Saccharomyces cerevisiae YBR042C; uncharacterized protein 600083 2896924 KLLA0_B06820g Kluyveromyces lactis uncharacterized protein XP_451836.1 598869 D 28985 CDS KLLA0_B06842g 2896934 complement(600154..602181) B 1 NC_006038.1 similar to uniprot|P38225 Saccharomyces cerevisiae YBR041W FAT1 Fatty acid transporter and very long-chain fatty acyl-CoA synthetase may form a complex with Faa1p or Faa4p that imports and activates exogenous fatty acids; long-chain fatty acid transporter FAT1 602181 2896934 KLLA0_B06842g Kluyveromyces lactis long-chain fatty acid transporter FAT1 XP_451837.1 600154 R 28985 CDS KLLA0_B06864g 2896928 complement(602511..603404) B 1 NC_006038.1 similar to uniprot|P38224 Saccharomyces cerevisiae YBR040W FIG1 Integral membrane protein required for efficient mating may participate in or regulate the low affinity Ca2 influx system which affects intracellular signaling and cell-cell fusion during mating; uncharacterized protein 603404 2896928 KLLA0_B06864g Kluyveromyces lactis uncharacterized protein XP_451838.1 602511 R 28985 CDS KLLA0_B06886g 2897171 complement(604332..605201) B 1 NC_006038.1 uniprot|P49377 Kluyveromyces lactis KLLA0B06886g ATP3 ATP synthase gamma chain mitochondrial precursor; F1F0 ATP synthase subunit gamma 605201 2897171 KLLA0_B06886g Kluyveromyces lactis F1F0 ATP synthase subunit gamma XP_451839.1 604332 R 28985 CDS KLLA0_B06952g 2896942 606694..609378 B 1 NC_006038.1 some similarities with uniprot|Q7LGR2 Saccharomyces cerevisiae YDR017C KCS1 Inositol hexaphosphate kinase phosphorylates inositol hexakisphosphate (InsP6) to diphosphoinositol polyphosphates required for proper vacuole morphology and involved in salt stress response contains two leucine heptad repeats; inositol polyphosphate kinase KCS1 609378 2896942 KLLA0_B06952g Kluyveromyces lactis inositol polyphosphate kinase KCS1 XP_451840.1 606694 D 28985 CDS KLLA0_B06974g 2896954 610375..610662 B 1 NC_006038.1 similar to uniprot|Q12248 Saccharomyces cerevisiae YDR016C DAD1 Essential protein component of the DASH complex involved in spindle integrity and kinetochore function interacts with Duo1p and Dam1p localizes to intranuclear spindles and kinetochore; uncharacterized protein 610662 2896954 KLLA0_B06974g Kluyveromyces lactis uncharacterized protein XP_451841.1 610375 D 28985 CDS KLLA0_B07040g 2897503 613103..614116 B 1 NC_006038.1 similar to uniprot|Q08913 Saccharomyces cerevisiae YPL279C and similar to YOR390w; uncharacterized protein 614116 2897503 KLLA0_B07040g Kluyveromyces lactis uncharacterized protein XP_451843.1 613103 D 28985 CDS KLLA0_B07062g 2896971 614589..615266 B 1 NC_006038.1 highly similar to uniprot|P38075 Saccharomyces cerevisiae YBR035C PDX3 Pyridoxine (pyridoxamine) phosphate oxidase has homologs in E. coli and Myxococcus xanthus transcription is under the general control of nitrogen metabolism; pyridoxamine-phosphate oxidase PDX3 615266 2896971 KLLA0_B07062g Kluyveromyces lactis pyridoxamine-phosphate oxidase PDX3 XP_451844.1 614589 D 28985 CDS KLLA0_B07084g 2897099 complement(615326..617071) B 1 NC_006038.1 weakly similar to uniprot|Q99359 Saccharomyces cerevisiae YDR014W RAD61 Protein of unknown function mutation confers radiation sensitivity; uncharacterized protein 617071 2897099 KLLA0_B07084g Kluyveromyces lactis uncharacterized protein XP_451845.1 615326 R 28985 CDS KLLA0_B07095g 2897097 617330..617965 B 1 NC_006038.1 highly similar to uniprot|Q12488 Saccharomyces cerevisiae YDR013W PSF1 Subunit of the GINS complex (Sld5p Psf1p Psf2p Psf3p) which binds to DNA replication origins and facilitates assembly of the DNA replication machinery; DNA replication protein PSF1 617965 2897097 KLLA0_B07095g Kluyveromyces lactis DNA replication protein PSF1 XP_451846.2 617330 D 28985 CDS KLLA0_B07117g 2897067 618368..619414 B 1 NC_006038.1 highly similar to uniprot|P38074 Saccharomyces cerevisiae YBR034C HMT1 Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs including Npl3p and Hrp1p thus facilitating nuclear export of these proteins required for viability of npl3 mutants; protein-arginine omega-N methyltransferase HMT1 619414 2897067 KLLA0_B07117g Kluyveromyces lactis protein-arginine omega-N methyltransferase HMT1 XP_451847.1 618368 D 28985 CDS KLLA0_B07139g 2897143 complement(620003..621094) B 1 NC_006038.1 highly similar to uniprot|P49626 Saccharomyces cerevisiae YDR012W RPL4B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Ap; 60S ribosomal protein uL4 621094 2897143 KLLA0_B07139g Kluyveromyces lactis 60S ribosomal protein uL4 XP_451848.1 620003 R 28985 CDS KLLA0_B07161g 2897142 complement(621391..623052) B 1 NC_006038.1 weakly similar to uniprot|P38222 Saccharomyces cerevisiae YBR030W; protein-lysine N-methyltransferase 623052 2897142 KLLA0_B07161g Kluyveromyces lactis protein-lysine N-methyltransferase XP_451849.1 621391 R 28985 CDS KLLA0_B07183g 2897047 complement(623544..623936) B 1 NC_006038.1 similar to uniprot|P32388 Saccharomyces cerevisiae YKL167C MRP49 Mitochondrial ribosomal protein of the large subunit not essential for mitochondrial translation; mitochondrial 54S ribosomal protein mL61 623936 2897047 KLLA0_B07183g Kluyveromyces lactis mitochondrial 54S ribosomal protein mL61 XP_451850.1 623544 R 28985 CDS KLLA0_B07205g 2897077 complement(624606..625973) B 1 NC_006038.1 similar to uniprot|P05986 Saccharomyces cerevisiae YKL166C TPK3 Involved in nutrient control of cell growth and division cAMP-dependent protein kinase catalytic subunit and to YJL164C uniprot|P06244 Saccharomyces cerevisiae YJL164C TPK1 putative catalytic subunit of cAMP-dependent protein kinase; uncharacterized protein 625973 2897077 KLLA0_B07205g Kluyveromyces lactis uncharacterized protein XP_451851.1 624606 R 28985 CDS KLLA0_B07227g 2897044 complement(627833..629695) B 1 NC_006038.1 similar to uniprot|P46996 Saccharomyces cerevisiae YJL163C; uncharacterized protein 629695 2897044 KLLA0_B07227g Kluyveromyces lactis uncharacterized protein XP_451852.1 627833 R 28985 CDS KLLA0_B07249g 2897133 complement(630336..633095) B 1 NC_006038.1 highly similar to uniprot|P36051 Saccharomyces cerevisiae YKL165C MCD4 Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis multimembrane-spanning protein that localizes to the endoplasmic reticulum highly conserved among eukaryotes; mannose-ethanolamine phosphotransferase MCD4 633095 2897133 KLLA0_B07249g Kluyveromyces lactis mannose-ethanolamine phosphotransferase MCD4 XP_451853.1 630336 R 28985 CDS KLLA0_B07271g 2897123 complement(633724..635685) B 1 NC_006038.1 some similarities with uniprot|P46997 Saccharomyces cerevisiae YJL162C JJJ2 Protein that may function as a cochaperone as suggested by the presence of a DnaJ-like domain; uncharacterized protein 635685 2897123 KLLA0_B07271g Kluyveromyces lactis uncharacterized protein XP_451854.1 633724 R 28985 CDS KLLA0_B07337g 2897255 637267..637788 B 1 NC_006038.1 weakly similar to uniprot|P46998 Saccharomyces cerevisiae YJL161w; uncharacterized protein 637788 2897255 KLLA0_B07337g Kluyveromyces lactis uncharacterized protein XP_451855.1 637267 D 28985 CDS KLLA0_B07370g 2897377 complement(638135..639031) B 1 NC_006038.1 similar to uniprot|Q03178 Saccharomyces cerevisiae YKL164C PIR1 Protein containing tandem internal repeats; uncharacterized protein 639031 2897377 KLLA0_B07370g Kluyveromyces lactis uncharacterized protein XP_451857.1 638135 R 28985 CDS KLLA0_B07392g 2897317 641481..642569 B 1 NC_006038.1 similar to uniprot|Q03178 Saccharomyces cerevisiae YKL164C PIR1 Protein containing tandem internal repeats; uncharacterized protein 642569 2897317 KLLA0_B07392g Kluyveromyces lactis uncharacterized protein XP_451858.1 641481 D 28985 CDS KLLA0_B07447g 2896894 complement(643757..644584) B 1 NC_006038.1 similar to uniprot|P47001 Saccharomyces cerevisiae YJL158C CIS3 cik1 suppressor Protein with homology to Hsp150p and Pir1p Pir2p and Pir3p; uncharacterized protein 644584 2896894 KLLA0_B07447g Kluyveromyces lactis uncharacterized protein XP_451860.1 643757 R 28985 CDS KLLA0_B07469g 2896882 complement(645646..648282) B 1 NC_006038.1 some similarities with uniprot|P21268 Saccharomyces cerevisiae YJL157C FAR1 Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone also forms a complex with Cdc24p Ste4p and Ste18p that may specify the direction of polarized growth during mating potential Cdc28p substrate; cyclin-dependent protein serine/threonine kinase inhibiting protein FAR1 648282 2896882 KLLA0_B07469g Kluyveromyces lactis cyclin-dependent protein serine/threonine kinase inhibiting protein FAR1 XP_451861.1 645646 R 28985 CDS KLLA0_B07491g 2897229 complement(649247..651346) B 1 NC_006038.1 similar to uniprot|P47002 Saccharomyces cerevisiae YJL156C SSY5 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; uncharacterized protein 651346 2897229 KLLA0_B07491g Kluyveromyces lactis uncharacterized protein XP_451862.1 649247 R 28985 CDS KLLA0_B07513g 2897393 complement(652357..653727) B 1 NC_006038.1 highly similar to uniprot|P32604 Saccharomyces cerevisiae YJL155C FBP26 Fructose-2 6-bisphosphatase required for glucose metabolism; fructose-2,6-bisphosphatase 653727 2897393 KLLA0_B07513g Kluyveromyces lactis fructose-2,6-bisphosphatase XP_451863.1 652357 R 28985 CDS KLLA0_B07535g 2897024 complement(654189..656828) B 1 NC_006038.1 similar to uniprot|P34110 Saccharomyces cerevisiae YJL154C VPS35 Protein involved in vacuolar sorting retromer complex component; retromer subunit VPS35 656828 2897024 KLLA0_B07535g Kluyveromyces lactis retromer subunit VPS35 XP_451864.1 654189 R 28985 CDS KLLA0_B07557g 2896897 657789..658829 B 1 NC_006038.1 similar to uniprot|P00431 Saccharomyces cerevisiae YKR066C CCP1 Mitochondrial cytochrome-c peroxidase degrades reactive oxygen species in mitochondria involved in the response to oxidative stress; cytochrome-c peroxidase 658829 2896897 KLLA0_B07557g Kluyveromyces lactis cytochrome-c peroxidase XP_451865.1 657789 D 28985 CDS KLLA0_B07579g 2896914 659591..661759 B 1 NC_006038.1 similar to uniprot|P32944 Saccharomyces cerevisiae YJL187C SWE1 Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity localizes to the nucleus and to the daughter side of the mother-bud neck homolog of S. pombe Wee1p potential Cdc28p substrate; tyrosine protein kinase SWE1 661759 2896914 KLLA0_B07579g Kluyveromyces lactis tyrosine protein kinase SWE1 XP_451866.1 659591 D 28985 CDS KLLA0_B07601g 2896891 664026..664418 B 1 NC_006038.1 highly similar to uniprot|P04648 Saccharomyces cerevisiae YLR367W RPS22B and to uniprot|P04648 Saccharomyces cerevisiae YJL190C RPS22A Proteins component of the small (40S) ribosomal subunit; 40S ribosomal protein uS8 664418 2896891 KLLA0_B07601g Kluyveromyces lactis 40S ribosomal protein uS8 XP_451868.1 664026 D 28985 CDS KLLA0_B07623g 2897042 complement(join(664788..665191,665949..665958)) B 1 NC_006038.1 uniprot|P27069 Kluyveromyces lactis KLLA0B07623g RPS14 40S ribosomal protein S14; 40S ribosomal protein uS11 665958 2897042 KLLA0_B07623g Kluyveromyces lactis 40S ribosomal protein uS11 XP_451869.1 664788 R 28985 CDS KLLA0_B07645g 2897048 666889..667593 B 1 NC_006038.1 similar to uniprot|P39543 Saccharomyces cerevisiae YJL192C SOP4 suppressor of pma1-7; uncharacterized protein 667593 2897048 KLLA0_B07645g Kluyveromyces lactis uncharacterized protein XP_451870.1 666889 D 28985 CDS KLLA0_B07667g 2897057 667863..673862 B 1 NC_006038.1 some similarities with uniprot|P25356 Saccharomyces cerevisiae YCR032W BPH1; uncharacterized protein 673862 2897057 KLLA0_B07667g Kluyveromyces lactis uncharacterized protein XP_451871.1 667863 D 28985 CDS KLLA0_B07689g 2897137 complement(673884..675017) B 1 NC_006038.1 similar to uniprot|P39542 Saccharomyces cerevisiae YJL193W; uncharacterized protein 675017 2897137 KLLA0_B07689g Kluyveromyces lactis uncharacterized protein XP_451872.1 673884 R 28985 CDS KLLA0_B07711g 2897027 complement(675600..677111) B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 677111 2897027 KLLA0_B07711g Kluyveromyces lactis uncharacterized protein XP_451873.1 675600 R 28985 CDS KLLA0_B07733g 2897163 677879..679177 B 1 NC_006038.1 highly similar to uniprot|Q12109 Saccharomyces cerevisiae YOL097C WRS1 Cytoplasmic tryptophanyl-tRNA synthetase aminoacylates tryptophanyl-tRNA; tryptophan--tRNA ligase WRS1 679177 2897163 KLLA0_B07733g Kluyveromyces lactis tryptophan--tRNA ligase WRS1 XP_451874.1 677879 D 28985 CDS KLLA0_B07755g 2897089 complement(679506..680135) B 1 NC_006038.1 similar to uniprot|Q99258 Saccharomyces cerevisiae YDR487C RIB3 3 4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase) required for riboflavin biosynthesis from ribulose-5-phosphate also has an unrelated function in mitochondrial respiration; 3,4-dihydroxy-2-butanone-4-phosphate synthase RIB3 680135 2897089 KLLA0_B07755g Kluyveromyces lactis 3,4-dihydroxy-2-butanone-4-phosphate synthase RIB3 XP_451875.1 679506 R 28985 CDS KLLA0_B07777g 2897192 complement(681163..682191) B 1 NC_006038.1 similar to uniprot|P40319 Saccharomyces cerevisiae YLR372W SUR4 Elongase III synthesizes 20-26-carbon fatty acids from C18-CoA primers involved in fatty acid biosynthesis; fatty acid elongase ELO3 682191 2897192 KLLA0_B07777g Kluyveromyces lactis fatty acid elongase ELO3 XP_451876.1 681163 R 28985 CDS KLLA0_B07799g 2897147 complement(682960..686643) B 1 NC_006038.1 similar to uniprot|P51862 Saccharomyces cerevisiae YLR371W ROM2 GDP/GTP exchange protein (GEP) for Rho1p and Rho2p mutations are synthetically lethal with mutations in rom1 which also encodes a GEP; uncharacterized protein 686643 2897147 KLLA0_B07799g Kluyveromyces lactis uncharacterized protein XP_451877.1 682960 R 28985 CDS KLLA0_B07821g 2897259 687701..688231 B 1 NC_006038.1 highly similar to uniprot|Q05933 Saccharomyces cerevisiae YLR370C ARC18 Subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches; uncharacterized protein 688231 2897259 KLLA0_B07821g Kluyveromyces lactis uncharacterized protein XP_451878.1 687701 D 28985 CDS KLLA0_B07843g 2897165 complement(688371..690308) B 1 NC_006038.1 similar to uniprot|Q05931 Saccharomyces cerevisiae YLR369W SSQ1 Mitochondrial hsp70-type molecular chaperone involved in the synthesis and assembly of iron/sulfur clusters into proteins; Hsp70 family ATPase SSQ1 690308 2897165 KLLA0_B07843g Kluyveromyces lactis Hsp70 family ATPase SSQ1 XP_451879.1 688371 R 28985 CDS KLLA0_B07865g 2897202 complement(690559..692301) B 1 NC_006038.1 some similarities with YLR368W MDM30 F-box protein; uncharacterized protein 692301 2897202 KLLA0_B07865g Kluyveromyces lactis uncharacterized protein XP_451880.1 690559 R 28985 CDS KLLA0_B07887g 2897358 693510..695624 B 1 NC_006038.1 similar to uniprot|P53244 Saccharomyces cerevisiae YGR068C; uncharacterized protein 695624 2897358 KLLA0_B07887g Kluyveromyces lactis uncharacterized protein XP_451881.1 693510 D 28985 CDS KLLA0_B07909g 2897278 697885..700653 B 1 NC_006038.1 some similarities with uniprot|P53243 Saccharomyces cerevisiae YGR067C; uncharacterized protein 700653 2897278 KLLA0_B07909g Kluyveromyces lactis uncharacterized protein XP_451882.1 697885 D 28985 CDS KLLA0_B07931g 2897329 complement(join(701123..701382,701973..702104,702652)) B 1 NC_006038.1 highly similar to uniprot|P04648 Saccharomyces cerevisiae YLR367W RPS22B and to uniprot|P04648 Saccharomyces cerevisiae YJL190C RPS22A Proteins component of the small (40S) ribosomal subunit; 40S ribosomal protein uS8 702652 2897329 KLLA0_B07931g Kluyveromyces lactis 40S ribosomal protein uS8 XP_451883.2 701123 R 28985 CDS KLLA0_B07953g 2897384 703782..705578 B 1 NC_006038.1 highly similar to uniprot|P53241 Saccharomyces cerevisiae YGR065C VHT1 vitamin H transporter H -biotin symporter; uncharacterized protein 705578 2897384 KLLA0_B07953g Kluyveromyces lactis uncharacterized protein XP_451884.1 703782 D 28985 CDS KLLA0_B07975g 2897387 complement(705661..705996) B 1 NC_006038.1 similar to uniprot|Q05926 Saccharomyces cerevisiae YLR364W; glutathione-disulfide reductase GRX8 705996 2897387 KLLA0_B07975g Kluyveromyces lactis glutathione-disulfide reductase GRX8 XP_451885.1 705661 R 28985 CDS KLLA0_B07997g 2896970 706556..706864 B 1 NC_006038.1 uniprot|P81205 Kluyveromyces lactis KLLA0B07997g SPT4 Transcription elongation factor SPT4; transcription elongation factor SPT4 706864 2896970 KLLA0_B07997g Kluyveromyces lactis transcription elongation factor SPT4 XP_451886.1 706556 D 28985 CDS KLLA0_B08019g 2897124 707312..708253 B 1 NC_006038.1 uniprot|P78990 Kluyveromyces lactis KLLA0B08019g COX18 Inner membrane protein COX18 mitochondrial precursor; membrane insertase COX18 708253 2897124 KLLA0_B08019g Kluyveromyces lactis membrane insertase COX18 XP_451887.1 707312 D 28985 CDS KLLA0_B08041g 2897335 complement(708380..708649) B 1 NC_006038.1 similar to uniprot|Q3E747 Saccharomyces cerevisiae YLR363W-A; uncharacterized protein 708649 2897335 KLLA0_B08041g Kluyveromyces lactis uncharacterized protein XP_451888.1 708380 R 28985 CDS KLLA0_B08063g 2897462 709756..713805 B 1 NC_006038.1 highly similar to uniprot|P38972 Saccharomyces cerevisiae YGR061C ADE6 Formylglycinamidine-ribonucleotide (FGAM)-synthetase catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; phosphoribosylformylglycinamidine synthase 713805 2897462 KLLA0_B08063g Kluyveromyces lactis phosphoribosylformylglycinamidine synthase XP_451889.1 709756 D 28985 CDS KLLA0_B08085g 2897433 complement(714158..715108) B 1 NC_006038.1 highly similar to uniprot|P53045 Saccharomyces cerevisiae YGR060W ERG25 C-4 methyl sterol oxidase catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis mutants accumulate the sterol intermediate 4 4-dimethylzymosterol; methylsterol monooxygenase 715108 2897433 KLLA0_B08085g Kluyveromyces lactis methylsterol monooxygenase XP_451890.1 714158 R 28985 CDS KLLA0_B08107g 2896883 716305..717039 B 1 NC_006038.1 similar to uniprot|Q12129 Saccharomyces cerevisiae YLR363C NMD4 Protein interacting with Nam7p may be involved in the nonsense-mediated mRNA decay pathway; uncharacterized protein 717039 2896883 KLLA0_B08107g Kluyveromyces lactis uncharacterized protein XP_451891.1 716305 D 28985 CDS KLLA0_B08129g 2897475 complement(718086..719732) B 1 NC_006038.1 similar to uniprot|P41901 Saccharomyces cerevisiae YGR059W SPR3 a sporulation-specific homologue of the yeast CDC3/10/11/12 family of bud neck microfilament genes regulated by ABFI septin protein involved in sporulation; septin SPR3 719732 2897475 KLLA0_B08129g Kluyveromyces lactis septin SPR3 XP_451892.1 718086 R 28985 CDS KLLA0_B08151g 2896985 complement(720152..721240) B 1 NC_006038.1 similar to uniprot|P53238 Saccharomyces cerevisiae YGR058W; uncharacterized protein 721240 2896985 KLLA0_B08151g Kluyveromyces lactis uncharacterized protein XP_451893.1 720152 R 28985 CDS KLLA0_B08173g 2896964 complement(722254..722574) B 1 NC_006038.1 highly similar to uniprot|P46784 Saccharomyces cerevisiae YMR230W RPS10B and to uniprot|Q08745 Saccharomyces cerevisiae YOR293W RPS10A Proteins component of the small (40S) ribosomal subunit; 40S ribosomal protein eS10 722574 2896964 KLLA0_B08173g Kluyveromyces lactis 40S ribosomal protein eS10 XP_451894.1 722254 R 28985 CDS KLLA0_B08195g 2897041 723299..724291 B 1 NC_006038.1 similar to uniprot|Q08743 Saccharomyces cerevisiae YOR292C; uncharacterized protein 724291 2897041 KLLA0_B08195g Kluyveromyces lactis uncharacterized protein XP_451895.1 723299 D 28985 CDS KLLA0_B08217g 2897065 complement(724364..728683) B 1 NC_006038.1 similar to uniprot|Q12697 Saccharomyces cerevisiae YOR291W; uncharacterized protein 728683 2897065 KLLA0_B08217g Kluyveromyces lactis uncharacterized protein XP_451896.1 724364 R 28985 CDS KLLA0_B08239g 2897157 729850..735039 B 1 NC_006038.1 similar to uniprot|Q05022 Saccharomyces cerevisiae YMR229C RRP5 Part of small ribosomal subunit (SSU) processosome containing U3 snoRNA) required for the synthesis of both 18S and 5.8S rRNAs; uncharacterized protein 735039 2897157 KLLA0_B08239g Kluyveromyces lactis uncharacterized protein XP_451897.1 729850 D 28985 CDS KLLA0_B08261g 2897001 735279..736346 B 1 NC_006038.1 some similarities with uniprot|Q752K9 Ashbya gossypii AFR565C AFR565Cp; uncharacterized protein 736346 2897001 KLLA0_B08261g Kluyveromyces lactis uncharacterized protein XP_451898.1 735279 D 28985 CDS KLLA0_B08283g 2897078 complement(736483..737490) B 1 NC_006038.1 uniprot|P87250 Kluyveromyces lactis KLLA0B08283g MTF1 Mitochondrial replication protein MTF1; RNA polymerase specificity factor 737490 2897078 KLLA0_B08283g Kluyveromyces lactis RNA polymerase specificity factor XP_451899.1 736483 R 28985 CDS KLLA0_B08305g 2897402 737967..740174 B 1 NC_006038.1 some similarities with uniprot|Q05021 Saccharomyces cerevisiae YMR227C TAF7 TFIID subunit (67 kDa) involved in RNA polymerase II transcription initiation; TATA-binding protein-associated factor TAF7 740174 2897402 KLLA0_B08305g Kluyveromyces lactis TATA-binding protein-associated factor TAF7 XP_451900.1 737967 D 28985 CDS KLLA0_B08327g 2897166 742205..746809 B 1 NC_006038.1 similar to uniprot|P22082 Saccharomyces cerevisiae YOR290C SNF2 involved in the coordinate regulation of phospholipid synthesis transcriptional regulator; SWI/SNF catalytic subunit SNF2 746809 2897166 KLLA0_B08327g Kluyveromyces lactis SWI/SNF catalytic subunit SNF2 XP_451901.1 742205 D 28985 CDS KLLA0_B08371g 2897207 complement(747517..748323) B 1 NC_006038.1 highly similar to uniprot|Q05016 Saccharomyces cerevisiae YMR226C NADP()-dependent dehydrogenase acts on serine L-allo-threonine and other 3-hydroxy acids; oxidoreductase 748323 2897207 KLLA0_B08371g Kluyveromyces lactis oxidoreductase XP_451902.1 747517 R 28985 CDS KLLA0_B08415g 2897547 749520..749885 B 1 NC_006038.1 similar to uniprot|Q12160 Saccharomyces cerevisiae YPR063C; uncharacterized protein 749885 2897547 KLLA0_B08415g Kluyveromyces lactis uncharacterized protein XP_451903.1 749520 D 28985 CDS KLLA0_B08437g 2897540 complement(750194..750652) B 1 NC_006038.1 highly similar to uniprot|Q12178 Saccharomyces cerevisiae YPR062W FCY1 Cytosine deaminase involved in salvage pathways of pyrimidine metabolism; cytosine deaminase 750652 2897540 KLLA0_B08437g Kluyveromyces lactis cytosine deaminase XP_451904.1 750194 R 28985 CDS KLLA0_B08459g 2897343 751178..752065 B 1 NC_006038.1 similar to uniprot|Q12350 Saccharomyces cerevisiae YPR061C JID1 Probable Hsp40p co-chaperone has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain inhibits replication of Brome mosaic virus in S. cerevisiae; uncharacterized protein 752065 2897343 KLLA0_B08459g Kluyveromyces lactis uncharacterized protein XP_451905.1 751178 D 28985 CDS KLLA0_B08481g 2897365 752482..753264 B 1 NC_006038.1 highly similar to uniprot|P32178 Saccharomyces cerevisiae YPR060C ARO7 Chorismate mutase catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis; chorismate mutase ARO7 753264 2897365 KLLA0_B08481g Kluyveromyces lactis chorismate mutase ARO7 XP_451906.1 752482 D 28985 CDS KLLA0_B08503g 2897382 complement(753498..754409) B 1 NC_006038.1 similar to uniprot|P32331 Saccharomyces cerevisiae YPR058W YMC1 Putative mitochondrial inner membrane transporter member of the mitochondrial carrier (MCF) family; organic acid transporter 754409 2897382 KLLA0_B08503g Kluyveromyces lactis organic acid transporter XP_451907.1 753498 R 28985 CDS KLLA0_B08525g 2897328 complement(754935..755915) B 1 NC_006038.1 weakly similar to uniprot|Q99177 Saccharomyces cerevisiae YPR057W BRR1 snRNP protein component of spliceosomal snRNPs required for pre-mRNA splicing and snRNP biogenesis in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed; uncharacterized protein 755915 2897328 KLLA0_B08525g Kluyveromyces lactis uncharacterized protein XP_451908.1 754935 R 28985 CDS KLLA0_B08547g 2897398 756147..756512 B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 756512 2897398 KLLA0_B08547g Kluyveromyces lactis uncharacterized protein XP_451909.1 756147 D 28985 CDS KLLA0_B08569g 2897346 complement(756558..757571) B 1 NC_006038.1 similar to uniprot|Q12004 Saccharomyces cerevisiae YPR056W; TFIIH/NER complex subunit TFB4 757571 2897346 KLLA0_B08569g Kluyveromyces lactis TFIIH/NER complex subunit TFB4 XP_451910.1 756558 R 28985 CDS KLLA0_B08591g 2897390 758017..762252 B 1 NC_006038.1 similar to uniprot|Q03496 Saccharomyces cerevisiae YMR259C; tRNA methylation protein TRM732 762252 2897390 KLLA0_B08591g Kluyveromyces lactis tRNA methylation protein TRM732 XP_451911.1 758017 D 28985 CDS KLLA0_B08635g 2897460 762767..764416 B 1 NC_006038.1 similar to uniprot|Q04847 Saccharomyces cerevisiae YMR258C; uncharacterized protein 764416 2897460 KLLA0_B08635g Kluyveromyces lactis uncharacterized protein XP_451912.1 762767 D 28985 CDS KLLA0_B08657g 2897455 764962..767337 B 1 NC_006038.1 uniprot|Q9Y787 Kluyveromyces lactis KLLA0B08657g PET111 COX2 mRNA-specific translational activator Pet111; uncharacterized protein 767337 2897455 KLLA0_B08657g Kluyveromyces lactis uncharacterized protein XP_451913.1 764962 D 28985 CDS KLLA0_B08679g 2897463 767808..768899 B 1 NC_006038.1 weakly similar to uniprot|Q12161 Saccharomyces cerevisiae YOL054W PSH1 Nuclear protein putative RNA polymerase II elongation factor isolated as Pob3p/Spt16p-binding protein; ubiquitin-protein ligase PSH1 768899 2897463 KLLA0_B08679g Kluyveromyces lactis ubiquitin-protein ligase PSH1 XP_451914.1 767808 D 28985 CDS KLLA0_B08712g 2896888 769252..769440 B 1 NC_006038.1 highly similar to uniprot|P10174 Saccharomyces cerevisiae YMR256C COX7 Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; cytochrome c oxidase subunit VII 769440 2896888 KLLA0_B08712g Kluyveromyces lactis cytochrome c oxidase subunit VII XP_451916.2 769252 D 28985 CDS KLLA0_B08734g 2897348 770125..771147 B 1 NC_006038.1 similar to uniprot|Q05667 Saccharomyces cerevisiae YOL053W; uncharacterized protein 771147 2897348 KLLA0_B08734g Kluyveromyces lactis uncharacterized protein XP_451917.1 770125 D 28985 CDS KLLA0_B08756g 2897481 complement(771322..771966) B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 771966 2897481 KLLA0_B08756g Kluyveromyces lactis uncharacterized protein XP_451918.1 771322 R 28985 CDS KLLA0_B08778g 2896884 772247..772606 B 1 NC_006038.1 similar to uniprot|Q04814 Saccharomyces cerevisiae YMR252C; uncharacterized protein 772606 2896884 KLLA0_B08778g Kluyveromyces lactis uncharacterized protein XP_451919.1 772247 D 28985 CDS KLLA0_B08800g 2897476 complement(772732..774444) B 1 NC_006038.1 similar to uniprot|P22580 Saccharomyces cerevisiae YDR242W AMD2 Putative amidase; uncharacterized protein 774444 2897476 KLLA0_B08800g Kluyveromyces lactis uncharacterized protein XP_451920.1 772732 R 28985 CDS KLLA0_B08822g 2896906 775550..777016 B 1 NC_006038.1 highly similar to uniprot|Q00764 Saccharomyces cerevisiae YBR126C TPS1 Probable regulator of glucose influx into the cell & into glycolytic pathway indirectly regulating glucose-induced signalling (activation & inactivation) & initial step(s) of glucose metabolism. Homologue of E. coli otsA protein 56 kD synthase subunit of trehalose-6-phosphate synthase/phosphatase complex; alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1 777016 2896906 KLLA0_B08822g Kluyveromyces lactis alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1 XP_451921.1 775550 D 28985 CDS KLLA0_B08844g 2896987 777472..778674 B 1 NC_006038.1 similar to uniprot|P38089 Saccharomyces cerevisiae YBR125C PTC4 Cytoplasmic type 2C protein phosphatase identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity; type 2C protein phosphatase PTC4 778674 2896987 KLLA0_B08844g Kluyveromyces lactis type 2C protein phosphatase PTC4 XP_451922.1 777472 D 28985 CDS KLLA0_B08866g 2896895 779130..780962 B 1 NC_006038.1 similar to uniprot|P32367 Saccharomyces cerevisiae YBR123C subunit of the RNA polymerase III transcription initiation factor complex (TFIIIC); transcription factor TFIIIC subunit TFC1 780962 2896895 KLLA0_B08866g Kluyveromyces lactis transcription factor TFIIIC subunit TFC1 XP_451923.1 779130 D 28985 CDS KLLA0_B08888g 2897088 781251..781766 B 1 NC_006038.1 similar to uniprot|P36531 Saccharomyces cerevisiae YBR122C MRPL36 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein bL31m 781766 2897088 KLLA0_B08888g Kluyveromyces lactis mitochondrial 54S ribosomal protein bL31m XP_451924.1 781251 D 28985 CDS KLLA0_B08910g 2896952 782025..782456 B 1 NC_006038.1 highly similar to uniprot|Q06819 Saccharomyces cerevisiae YPR082C DIB1 component of the U4/U6aU5 tri-snRNP; U4/U6-U5 snRNP complex subunit DIB1 782456 2896952 KLLA0_B08910g Kluyveromyces lactis U4/U6-U5 snRNP complex subunit DIB1 XP_451925.1 782025 D 28985 CDS KLLA0_B08932g 2897118 783004..784995 B 1 NC_006038.1 highly similar to uniprot|P38088 Saccharomyces cerevisiae YBR121C GRS1 glycyl-tRNA synthase; glycine--tRNA ligase 784995 2897118 KLLA0_B08932g Kluyveromyces lactis glycine--tRNA ligase XP_451926.1 783004 D 28985 CDS KLLA0_B08954g 2897491 785408..785878 B 1 NC_006038.1 similar to uniprot|P07253 Saccharomyces cerevisiae YBR120C CBP6 Translational activator of COB mRNA; uncharacterized protein 785878 2897491 KLLA0_B08954g Kluyveromyces lactis uncharacterized protein XP_451927.1 785408 D 28985 CDS KLLA0_B08976g 2897511 complement(786122..787039) B 1 NC_006038.1 similar to uniprot|P32605 Saccharomyces cerevisiae YBR119W MUD1 U1 snRNP A protein homolog of human U1-A involved in nuclear mRNA splicing; uncharacterized protein 787039 2897511 KLLA0_B08976g Kluyveromyces lactis uncharacterized protein XP_451928.1 786122 R 28985 CDS KLLA0_B08998g 2897093 complement(787497..788873) B 1 NC_006038.1 highly similar to uniprot|P02994 Saccharomyces cerevisiae YPR080W TEF1 functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes translational elongation factor EF-1 alpha; translation elongation factor EF-1 alpha 788873 2897093 KLLA0_B08998g Kluyveromyces lactis translation elongation factor EF-1 alpha XP_451929.1 787497 R 28985 CDS KLLA0_B09020g 2897536 complement(790295..791305) B 1 NC_006038.1 similar to uniprot|Q06815 Saccharomyces cerevisiae YPR079W MRL1 Membrane protein; uncharacterized protein 791305 2897536 KLLA0_B09020g Kluyveromyces lactis uncharacterized protein XP_451930.1 790295 R 28985 CDS KLLA0_B09042g 2897113 791864..792355 B 1 NC_006038.1 no similarity; uncharacterized protein 792355 2897113 KLLA0_B09042g Kluyveromyces lactis uncharacterized protein XP_451931.1 791864 D 28985 CDS KLLA0_B09064g 2897174 complement(792849..793973) B 1 NC_006038.1 uniprot|P49384 Kluyveromyces lactis KLLA0B09064g ADH3 Alcohol dehydrogenase III mitochondrial precursor; uncharacterized protein 793973 2897174 KLLA0_B09064g Kluyveromyces lactis uncharacterized protein XP_451932.1 792849 R 28985 CDS KLLA0_B09108g 2897374 complement(795534..796331) B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 796331 2897374 KLLA0_B09108g Kluyveromyces lactis uncharacterized protein XP_451934.1 795534 R 28985 CDS KLLA0_B09130g 2897532 797768..799009 B 1 NC_006038.1 some similarities with sgd|S0006279 uniprot|Q6B149 Saccharomyces cerevisiae YPR075c OPY2 pheromone resistant yeast 2; uncharacterized protein 799009 2897532 KLLA0_B09130g Kluyveromyces lactis uncharacterized protein XP_451935.1 797768 D 28985 CDS KLLA0_B09152g 2896867 800238..802277 B 1 NC_006038.1 uniprot|Q12630 Kluyveromyces lactis KLLA0B09152g TKL1 Transketolase; uncharacterized protein 802277 2896867 KLLA0_B09152g Kluyveromyces lactis uncharacterized protein XP_451936.1 800238 D 28985 CDS KLLA0_B09174g 2897338 802641..803114 B 1 NC_006038.1 similar to uniprot|P40347 Saccharomyces cerevisiae YPR073C LTP1 phosphatase; tyrosine protein phosphatase LTP1 803114 2897338 KLLA0_B09174g Kluyveromyces lactis tyrosine protein phosphatase LTP1 XP_451937.1 802641 D 28985 CDS KLLA0_B09196g 2897361 complement(803259..805031) B 1 NC_006038.1 similar to uniprot|Q12514 Saccharomyces cerevisiae YPR072W NOT5 Subunit of global transcriptional regulator; CCR4-NOT core subunit NOT5 805031 2897361 KLLA0_B09196g Kluyveromyces lactis CCR4-NOT core subunit NOT5 XP_451938.1 803259 R 28985 CDS KLLA0_B09218g 2897319 805915..810072 B 1 NC_006038.1 uniprot|Q8NJ21 Kluyveromyces lactis lys2 Alpha-aminoadipate reductase; L-aminoadipate-semialdehyde dehydrogenase 810072 2897319 KLLA0_B09218g Kluyveromyces lactis L-aminoadipate-semialdehyde dehydrogenase XP_451939.1 805915 D 28985 CDS KLLA0_B09240g 2897376 complement(810178..812574) B 1 NC_006038.1 highly similar to uniprot|P31244 Saccharomyces cerevisiae YBR114W RAD16 Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair subunit of Nucleotide Excision Repair Factor 4 (NEF4) member of the SWI/SNF family; DNA repair protein RAD16 812574 2897376 KLLA0_B09240g Kluyveromyces lactis DNA repair protein RAD16 XP_451940.2 810178 R 28985 CDS KLLA0_B09262g 2897320 814303..817128 B 1 NC_006038.1 highly similar to uniprot|P14922 Saccharomyces cerevisiae YBR112C CYC8 General transcriptional co-repressor acts together with Tup1p also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; transcription regulator CYC8 817128 2897320 KLLA0_B09262g Kluyveromyces lactis transcription regulator CYC8 XP_451941.1 814303 D 28985 CDS KLLA0_B09284g 2897327 complement(817377..817667) B 1 NC_006038.1 similar to uniprot|Q6WNK7 Saccharomyces cerevisiae YBR111W-A SUS1 Protein involved in mRNA export coupled transcription activation component of the SAGA histone acetylase complex; uncharacterized protein 817667 2897327 KLLA0_B09284g Kluyveromyces lactis uncharacterized protein XP_451942.1 817377 R 28985 CDS KLLA0_B09306g 2897449 818061..818732 B 1 NC_006038.1 similar to uniprot|Q01976 Saccharomyces cerevisiae YBR111C; ADP-ribose diphosphatase 818732 2897449 KLLA0_B09306g Kluyveromyces lactis ADP-ribose diphosphatase XP_451943.1 818061 D 28985 CDS KLLA0_B09350g 2896927 complement(819170..820450) B 1 NC_006038.1 similar to uniprot|Q12321 Saccharomyces cerevisiae YPR070W MED1 transcriptional regulator; uncharacterized protein 820450 2896927 KLLA0_B09350g Kluyveromyces lactis uncharacterized protein XP_451944.1 819170 R 28985 CDS KLLA0_B09372g 2897494 821388..822269 B 1 NC_006038.1 highly similar to uniprot|Q12074 Saccharomyces cerevisiae YPR069C SPE3 biosynthesis of spermidine putrescine aminopropyltransferase (spermidine synthase); spermidine synthase 822269 2897494 KLLA0_B09372g Kluyveromyces lactis spermidine synthase XP_451945.1 821388 D 28985 CDS KLLA0_B09394g 2896951 822629..823954 B 1 NC_006038.1 similar to uniprot|Q12214 Saccharomyces cerevisiae YPR068C HOS1 Putative class I histone deacetylase (HDAC) with sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; deletion results in increased histone acetylation at rDNA repeats; interacts with the Tup1p-Ssn6p complex; histone deacetylase 823954 2896951 KLLA0_B09394g Kluyveromyces lactis histone deacetylase XP_451946.1 822629 D 28985 CDS KLLA0_B09405g 2896930 complement(823945..825288) B 1 NC_006038.1 similar to uniprot|P16661 Saccharomyces cerevisiae YBR110W ALG1 Mannosyltransferase in the endoplasmic reticulum; chitobiosyldiphosphodolichol beta-1,4 mannosyltransferase 825288 2896930 KLLA0_B09405g Kluyveromyces lactis chitobiosyldiphosphodolichol beta-1,4 mannosyltransferase XP_451947.1 823945 R 28985 CDS KLLA0_B09427g 2897167 825951..826394 B 1 NC_006038.1 uniprot|O60041 Kluyveromyces lactis KLLA0B09427g CMD1 Calmodulin; calmodulin 826394 2897167 KLLA0_B09427g Kluyveromyces lactis calmodulin XP_451949.1 825951 D 28985 CDS KLLA0_B09460g 2897066 complement(826867..829446) B 1 NC_006038.1 similar to uniprot|P38266 Saccharomyces cerevisiae YBR108W Protein interacting with Rsv167p; uncharacterized protein 829446 2897066 KLLA0_B09460g Kluyveromyces lactis uncharacterized protein XP_451950.1 826867 R 28985 CDS KLLA0_B09482g 2897013 829842..830426 B 1 NC_006038.1 no similarity; uncharacterized protein 830426 2897013 KLLA0_B09482g Kluyveromyces lactis uncharacterized protein XP_451951.1 829842 D 28985 CDS KLLA0_B09504g 2897146 complement(830548..831120) B 1 NC_006038.1 similar to uniprot|Q12425 Saccharomyces cerevisiae YPR067W ISA2; uncharacterized protein 831120 2897146 KLLA0_B09504g Kluyveromyces lactis uncharacterized protein XP_451952.1 830548 R 28985 CDS KLLA0_B09526g 2897277 complement(831336..832277) B 1 NC_006038.1 similar to uniprot|Q99344 Saccharomyces cerevisiae YPR066W UBA3 Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation) which may play a role in protein degradation GFP-fusion protein localizes to the cytoplasm in a punctate pattern; NEDD8-activating protein UBA3 832277 2897277 KLLA0_B09526g Kluyveromyces lactis NEDD8-activating protein UBA3 XP_451953.1 831336 R 28985 CDS KLLA0_B09548g 2897050 complement(832583..833155) B 1 NC_006038.1 highly similar to uniprot|P38264 Saccharomyces cerevisiae YBR106W PHO88 Probable membrane protein involved in phosphate transport; uncharacterized protein 833155 2897050 KLLA0_B09548g Kluyveromyces lactis uncharacterized protein XP_451954.1 832583 R 28985 CDS KLLA0_B09592g 2897169 834414..835415 B 1 NC_006038.1 similar to uniprot|P38263 Saccharomyces cerevisiae YBR105C VID24 also involved in vacuolar protein targeting peripheral vesicle membrane protein; glucose-induced degradation complex subunit VID24 835415 2897169 KLLA0_B09592g Kluyveromyces lactis glucose-induced degradation complex subunit VID24 XP_451956.1 834414 D 28985 CDS KLLA0_B09636g 2897284 836265..836693 B 1 NC_006038.1 similar to uniprot|Q02784 Saccharomyces cerevisiae YPL059W GRX5 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers monothiol glutaredoxin subfamily member along with Grx3p and Grx4p; monothiol glutaredoxin GRX5 836693 2897284 KLLA0_B09636g Kluyveromyces lactis monothiol glutaredoxin GRX5 XP_451957.1 836265 D 28985 CDS KLLA0_B09658g 2897464 complement(837873..838901) B 1 NC_006038.1 similar to uniprot|Q06494 Saccharomyces cerevisiae YPR127W; pyridoxine 4-dehydrogenase 838901 2897464 KLLA0_B09658g Kluyveromyces lactis pyridoxine 4-dehydrogenase XP_451958.1 837873 R 28985 CDS KLLA0_B09680g 2897391 complement(840160..841818) B 1 NC_006038.1 similar to uniprot|P38289 Saccharomyces cerevisiae YBR163W; uncharacterized protein 841818 2897391 KLLA0_B09680g Kluyveromyces lactis uncharacterized protein XP_451959.1 840160 R 28985 CDS KLLA0_B09702g 2897457 complement(842245..846801) B 1 NC_006038.1 highly similar to uniprot|Q02785 Saccharomyces cerevisiae YPL058C PDR12 Plasma membrane weak-acid-inducible ATP-binding cassette (ABC) transporter required for weak organic acid resistance strongly induced by sorbate and benzoate regulated by War1p mutants exhibit sorbate hypersensitivity; ATP-binding cassette multidrug transporter PDR12 846801 2897457 KLLA0_B09702g Kluyveromyces lactis ATP-binding cassette multidrug transporter PDR12 XP_451960.1 842245 R 28985 CDS KLLA0_B09724g 2896858 complement(848785..848979) B 1 NC_006038.1 similar to uniprot|P38374 Saccharomyces cerevisiae YBR162W-A YSY6 Protein that participates in secretory pathway; uncharacterized protein 848979 2896858 KLLA0_B09724g Kluyveromyces lactis uncharacterized protein XP_451961.1 848785 R 28985 CDS KLLA0_B09746g 2897505 850402..851775 B 1 NC_006038.1 similar to uniprot|P38288 Saccharomyces cerevisiae YBR162C TOS1 Target of SBF; uncharacterized protein 851775 2897505 KLLA0_B09746g Kluyveromyces lactis uncharacterized protein XP_451962.1 850402 D 28985 CDS KLLA0_B09768g 2897082 complement(852589..853665) B 1 NC_006038.1 similar to uniprot|P33300 Saccharomyces cerevisiae YPL057C SUR1 and similar to uniprot|P38287 Saccharomyces cerevisiae YBR161w CSH1 Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase forms a complex with probable regulatory subunit Csg2p; mannosylinositol phosphorylceramide synthase catalytic subunit CSH1 853665 2897082 KLLA0_B09768g Kluyveromyces lactis mannosylinositol phosphorylceramide synthase catalytic subunit CSH1 XP_451963.1 852589 R 28985 CDS KLLA0_B09790g 2896999 complement(855327..856214) B 1 NC_006038.1 highly similar to uniprot|P00546 Saccharomyces cerevisiae YBR160W CDC28 Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK) alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates; cyclin-dependent serine/threonine-protein kinase CDC28 856214 2896999 KLLA0_B09790g Kluyveromyces lactis cyclin-dependent serine/threonine-protein kinase CDC28 XP_451964.1 855327 R 28985 CDS KLLA0_B09812g 2897485 complement(856799..857839) B 1 NC_006038.1 similar to uniprot|P38286 Saccharomyces cerevisiae YBR159W microsomal beta-keto-reductase; ketoreductase 857839 2897485 KLLA0_B09812g Kluyveromyces lactis ketoreductase XP_451965.1 856799 R 28985 CDS KLLA0_B09834g 2897486 complement(858130..858822) B 1 NC_006038.1 some similarities with uniprot|Q6Q5I8 Saccharomyces cerevisiae YPL055C LGE1 Protein of unknown function null mutant forms abnormally large cells; uncharacterized protein 858822 2897486 KLLA0_B09834g Kluyveromyces lactis uncharacterized protein XP_451966.1 858130 R 28985 CDS KLLA0_B09856g 2897177 complement(859162..860436) B 1 NC_006038.1 weakly similar to uniprot|P38285 Saccharomyces cerevisiae YBR158W AMN1 Involved in daughter cell separation and Chromosome STability Chromosome STability; uncharacterized protein 860436 2897177 KLLA0_B09856g Kluyveromyces lactis uncharacterized protein XP_451967.1 859162 R 28985 CDS KLLA0_B09878g 2897395 862234..863529 B 1 NC_006038.1 some similarities with uniprot|Q06701 Saccharomyces cerevisiae YPL054W LEE1 Protein of unknown function; uncharacterized protein 863529 2897395 KLLA0_B09878g Kluyveromyces lactis uncharacterized protein XP_451968.1 862234 D 28985 CDS KLLA0_B09900g 2896886 866210..867571 B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 867571 2896886 KLLA0_B09900g Kluyveromyces lactis uncharacterized protein XP_451969.1 866210 D 28985 CDS KLLA0_B09922g 2897478 complement(867748..870141) B 1 NC_006038.1 weakly similar to uniprot|Q03770 Saccharomyces cerevisiae YDR160W SSY1 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; uncharacterized protein 870141 2897478 KLLA0_B09922g Kluyveromyces lactis uncharacterized protein XP_451970.1 867748 R 28985 CDS KLLA0_B09944g 2896872 870678..872702 B 1 NC_006038.1 weakly similar to uniprot|P38283 Saccharomyces cerevisiae YBR156C SLI15 Mitotic spindle protein involved in chromosome segregation.; uncharacterized protein 872702 2896872 KLLA0_B09944g Kluyveromyces lactis uncharacterized protein XP_451971.1 870678 D 28985 CDS KLLA0_B09966g 2896870 complement(872760..873872) B 1 NC_006038.1 similar to uniprot|P33313 Saccharomyces cerevisiae YBR155W CNS1 cyclophilin seven suppressor component of Hsp90p chaperone machinery; HSP70/90 family co-chaperone CNS1 873872 2896870 KLLA0_B09966g Kluyveromyces lactis HSP70/90 family co-chaperone CNS1 XP_451972.1 872760 R 28985 CDS KLLA0_B09988g 2896992 complement(874338..875621) B 1 NC_006038.1 similar to uniprot|P27809 Saccharomyces cerevisiae YDR483W KRE2 Alpha1 2-mannosyltransferase of the Golgi involved in protein mannosylation; uncharacterized protein 875621 2896992 KLLA0_B09988g Kluyveromyces lactis uncharacterized protein XP_451973.1 874338 R 28985 CDS KLLA0_B10010g 2896960 complement(join(876684..877423,877459..877540)) B 1 NC_006038.1 similar to uniprot|P53386 Saccharomyces cerevisiae YPR192W AQY1 Water channel that mediates the transport of water across cell membranes and may be involved in freeze tolerance; uncharacterized protein 877540 2896960 KLLA0_B10010g Kluyveromyces lactis uncharacterized protein XP_451974.2 876684 R 28985 CDS KLLA0_B10032g 2897003 879469..880047 B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 880047 2897003 KLLA0_B10032g Kluyveromyces lactis uncharacterized protein XP_451975.1 879469 D 28985 CDS KLLA0_B10054g 2897000 880175..880630 B 1 NC_006038.1 similar to uniprot|Q03375 Saccharomyces cerevisiae YDR482C; U2-type spliceosomal complex subunit CWC21 880630 2897000 KLLA0_B10054g Kluyveromyces lactis U2-type spliceosomal complex subunit CWC21 XP_451976.1 880175 D 28985 CDS KLLA0_B10076g 2897500 complement(881077..882549) B 1 NC_006038.1 some similarities with uniprot|Q751G8 Ashbya gossypii AGL262C AGL262Cp; uncharacterized protein 882549 2897500 KLLA0_B10076g Kluyveromyces lactis uncharacterized protein XP_451977.1 881077 R 28985 CDS KLLA0_B10098g 2897496 884810..885301 B 1 NC_006038.1 no similarity; uncharacterized protein 885301 2897496 KLLA0_B10098g Kluyveromyces lactis uncharacterized protein XP_451978.1 884810 D 28985 CDS KLLA0_B10120g 2897068 886187..887233 B 1 NC_006038.1 some similarities with uniprot|Q06674 Saccharomyces cerevisiae YDR317W; uncharacterized protein 887233 2897068 KLLA0_B10120g Kluyveromyces lactis uncharacterized protein XP_451979.1 886187 D 28985 CDS KLLA0_B10142g 2897499 join(887476..887527,887649..888478) B 1 NC_006038.1 similar to uniprot|Q06675 Saccharomyces cerevisiae YDR318W MCM21 Protein involved in minichromosome maintenance component of the COMA complex that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules; uncharacterized protein 888478 2897499 KLLA0_B10142g Kluyveromyces lactis uncharacterized protein XP_451980.2 887476 D 28985 CDS KLLA0_B10153g 2897508 complement(888468..889271) B 1 NC_006038.1 similar to uniprot|Q06676 Saccharomyces cerevisiae YDR319C; uncharacterized protein 889271 2897508 KLLA0_B10153g Kluyveromyces lactis uncharacterized protein XP_451981.1 888468 R 28985 CDS KLLA0_B10175g 2897060 889538..891733 B 1 NC_006038.1 highly similar to uniprot|P38604 Saccharomyces cerevisiae YHR072W ERG7 Lanosterol synthase an essential enzyme that catalyzes the cyclization of squalene 2 3-epoxide a step in ergosterol biosynthesis; lanosterol synthase ERG7 891733 2897060 KLLA0_B10175g Kluyveromyces lactis lanosterol synthase ERG7 XP_451982.1 889538 D 28985 CDS KLLA0_B10197g 2897075 complement(891842..893707) B 1 NC_006038.1 similar to uniprot|Q06677 Saccharomyces cerevisiae YDR320C SWA2 auxilin-like protein; uncharacterized protein 893707 2897075 KLLA0_B10197g Kluyveromyces lactis uncharacterized protein XP_451983.1 891842 R 28985 CDS KLLA0_B10219g 2897132 complement(893941..894480) B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 894480 2897132 KLLA0_B10219g Kluyveromyces lactis uncharacterized protein XP_451984.1 893941 R 28985 CDS KLLA0_B10241g 2897288 895841..896230 B 1 NC_006038.1 weakly similar to uniprot|Q12048 Saccharomyces cerevisiae YPL250C ICY2 Protein that interacts with the cytoskeleton and is involved in chromatin organization and nuclear transport; uncharacterized protein 896230 2897288 KLLA0_B10241g Kluyveromyces lactis uncharacterized protein XP_451985.1 895841 D 28985 CDS KLLA0_B10263g 2897176 896677..899916 B 1 NC_006038.1 similar to uniprot|Q04336 Saccharomyces cerevisiae YMR196W; uncharacterized protein 899916 2897176 KLLA0_B10263g Kluyveromyces lactis uncharacterized protein XP_451986.1 896677 D 28985 CDS KLLA0_B10285g 2897351 complement(900197..900862) B 1 NC_006038.1 similar to uniprot|Q04338 Saccharomyces cerevisiae YMR197C VTI1 Involved in cis-Golgi membrane traffic Vti1p is a v-SNARE that interacts with two t-SNARES Sed5p and Pep12p; v-SNARE protein VTI1 900862 2897351 KLLA0_B10285g Kluyveromyces lactis v-SNARE protein VTI1 XP_451987.1 900197 R 28985 CDS KLLA0_B10307g 2897187 901566..902066 B 1 NC_006038.1 similar to uniprot|Q12184 Saccharomyces cerevisiae YPL252C YAH1 Iron-sulfur protein of the mitochondrial matrix homologous to human adrenodoxin involved in heme a biosynthesis; adrenodoxin 902066 2897187 KLLA0_B10307g Kluyveromyces lactis adrenodoxin XP_451988.1 901566 D 28985 CDS KLLA0_B10329g 2897349 902691..904532 B 1 NC_006038.1 weakly similar to uniprot|Q01649 Saccharomyces cerevisiae YMR198W CIK1 is important for proper organiziation of microtubule arrays and establishment of a spindle is essential for karyogamy and expression is regulated by KAR4 and mating spindle pole body associated protein and to uniprot|Q12045 YPL253C VIK1 Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; uncharacterized protein 904532 2897349 KLLA0_B10329g Kluyveromyces lactis uncharacterized protein XP_451989.1 902691 D 28985 CDS KLLA0_B10351g 2897305 complement(904656..905954) B 1 NC_006038.1 similar to uniprot|Q12060 Saccharomyces cerevisiae YPL254W HFI1 Adaptor protein required for structural integrity of the SAGA complex a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions; uncharacterized protein 905954 2897305 KLLA0_B10351g Kluyveromyces lactis uncharacterized protein XP_451990.1 904656 R 28985 CDS KLLA0_B10373g 2897552 complement(906659..908362) B 1 NC_006038.1 some similarities with uniprot|P33757 Saccharomyces cerevisiae YBR250W; uncharacterized protein 908362 2897552 KLLA0_B10373g Kluyveromyces lactis uncharacterized protein XP_451991.1 906659 R 28985 CDS KLLA0_B10395g 2897406 complement(909517..910695) B 1 NC_006038.1 some similarities with uniprot|P33757 Saccharomyces cerevisiae YBR250W; uncharacterized protein 910695 2897406 KLLA0_B10395g Kluyveromyces lactis uncharacterized protein XP_451992.1 909517 R 28985 CDS KLLA0_B10406g 2897407 complement(910676..911113) B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 911113 2897407 KLLA0_B10406g Kluyveromyces lactis uncharacterized protein XP_451993.1 910676 R 28985 CDS KLLA0_B10428g 2896892 complement(911707..912192) B 1 NC_006038.1 no similarity; uncharacterized protein 912192 2896892 KLLA0_B10428g Kluyveromyces lactis uncharacterized protein XP_451994.1 911707 R 28985 CDS KLLA0_B10450g 2897479 912877..914046 B 1 NC_006038.1 some similarities with uniprot|P41817 Saccharomyces cerevisiae YPL177C CUP9 Homeodomain-containing transcriptional repressor of PTR2 which encodes a major peptide transporter imported peptides activate ubiquitin-dependent proteolysis resulting in degradation of Cup9p and de-repression of PTR2 transcription; uncharacterized protein 914046 2897479 KLLA0_B10450g Kluyveromyces lactis uncharacterized protein XP_451995.1 912877 D 28985 CDS KLLA0_B10472g 2896947 complement(914512..915108) B 1 NC_006038.1 highly similar to uniprot|Q08920 Saccharomyces cerevisiae YPL178W CBC2 Small subunit of the heterodimeric cap binding complex that also contains Sto1p component of the spliceosomal commitment complex interacts with Npl3p possibly to package mRNA for export from the nucleus contains an RNA-binding motif; nuclear cap-binding protein subunit CBC2 915108 2896947 KLLA0_B10472g Kluyveromyces lactis nuclear cap-binding protein subunit CBC2 XP_451996.1 914512 R 28985 CDS KLLA0_B10538g 2897006 919185..921380 B 1 NC_006038.1 similar to uniprot|P32784 Saccharomyces cerevisiae YBL011W SCT1 High copy suppressor of choline-transport mutants; bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1 921380 2897006 KLLA0_B10538g Kluyveromyces lactis bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1 XP_451998.1 919185 D 28985 CDS KLLA0_B10560g 2896943 complement(921743..923125) B 1 NC_006038.1 similar to uniprot|P34167 Saccharomyces cerevisiae YPR163C TIF3 Suppressor of translation mutants Translation initiation factor eIF-4B; uncharacterized protein 923125 2896943 KLLA0_B10560g Kluyveromyces lactis uncharacterized protein XP_451999.1 921743 R 28985 CDS KLLA0_B10582g 2897017 924069..931958 B 1 NC_006038.1 similar to uniprot|Q06179 Saccharomyces cerevisiae YLR454W FMP27 The authentic non-tagged protein was localized to the mitochondria; uncharacterized protein 931958 2897017 KLLA0_B10582g Kluyveromyces lactis uncharacterized protein XP_452000.1 924069 D 28985 CDS KLLA0_B10604g 2896968 932289..935693 B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 935693 2896968 KLLA0_B10604g Kluyveromyces lactis uncharacterized protein XP_452001.1 932289 D 28985 CDS KLLA0_B10626g 2897062 936497..937123 B 1 NC_006038.1 uniprot|Q8J212 Kluyveromyces lactis RHO1_KLULA Protein Rho1; Rho family GTPase RHO1 937123 2897062 KLLA0_B10626g Kluyveromyces lactis Rho family GTPase RHO1 XP_452002.1 936497 D 28985 CDS KLLA0_B10648g 2897015 complement(937752..938099) B 1 NC_006038.1 highly similar to uniprot|P10663 Saccharomyces cerevisiae YPR166C MRP2 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein uS14m 938099 2897015 KLLA0_B10648g Kluyveromyces lactis mitochondrial 37S ribosomal protein uS14m XP_452003.1 937752 R 28985 CDS KLLA0_B10670g 2897269 complement(938387..939217) B 1 NC_006038.1 weakly similar to uniprot|P32460 YIR030c Saccharomyces cerevisiae YIR030c DCG1 involved in nitrogen-catabolite metabolism; uncharacterized protein 939217 2897269 KLLA0_B10670g Kluyveromyces lactis uncharacterized protein XP_452004.1 938387 R 28985 CDS KLLA0_B10692g 2897394 complement(939675..940469) B 1 NC_006038.1 highly similar to uniprot|P18408 Saccharomyces cerevisiae YPR167C MET16 3'-phosphoadenylsulfate reductase reduces 3'-phosphoadenylyl sulfate to adenosine-3' 5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate involved in sulfate assimilation and methionine metabolism; phosphoadenylyl-sulfate reductase (thioredoxin) 940469 2897394 KLLA0_B10692g Kluyveromyces lactis phosphoadenylyl-sulfate reductase (thioredoxin) XP_452005.1 939675 R 28985 CDS KLLA0_B10714g 2897456 941126..941611 B 1 NC_006038.1 similar to uniprot|Q06213 Saccharomyces cerevisiae YPR168W NUT2 Component of the RNA polymerase II mediator complex which is required for transcriptional activation and also has a role in basal transcription; mediator complex subunit NUT2 941611 2897456 KLLA0_B10714g Kluyveromyces lactis mediator complex subunit NUT2 XP_452006.1 941126 D 28985 CDS KLLA0_B10736g 2897437 941796..943373 B 1 NC_006038.1 similar to uniprot|Q06214 Saccharomyces cerevisiae YPR169W JIP5 Nucleolar protein of unknown function exhibits a physical interaction with Bre1p; uncharacterized protein 943373 2897437 KLLA0_B10736g Kluyveromyces lactis uncharacterized protein XP_452007.1 941796 D 28985 CDS KLLA0_B10769g 9487376 join(943832..943849,943936..944066,944213..944321) B 1 NC_006038.1 highly similar to uniprot|P0C5R9 Saccharomyces cerevisiae YPR170W-B; uncharacterized protein 944321 9487376 KLLA0_B10769g Kluyveromyces lactis uncharacterized protein XP_002999355.1 943832 D 28985 CDS KLLA0_B10780g 2897109 944758..946434 B 1 NC_006038.1 some similarities with uniprot|Q06604 Saccharomyces cerevisiae YPR171W BSP1 Adapter that links synaptojanins Inp2p and Inp53p to the cortical actin cytoskeleton; uncharacterized protein 946434 2897109 KLLA0_B10780g Kluyveromyces lactis uncharacterized protein XP_452008.1 944758 D 28985 CDS KLLA0_B10802g 2897095 947115..948128 B 1 NC_006038.1 similar to uniprot|Q06188 Saccharomyces cerevisiae YLR455W; uncharacterized protein 948128 2897095 KLLA0_B10802g Kluyveromyces lactis uncharacterized protein XP_452009.1 947115 D 28985 CDS KLLA0_B10824g 2897032 948593..949180 B 1 NC_006038.1 similar to uniprot|Q06608 Saccharomyces cerevisiae YPR172W Protein of unknown function transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; pyridoxal 5'-phosphate synthase 949180 2897032 KLLA0_B10824g Kluyveromyces lactis pyridoxal 5'-phosphate synthase XP_452010.1 948593 D 28985 CDS KLLA0_B10846g 2897125 complement(949338..950630) B 1 NC_006038.1 highly similar to uniprot|P52917 Saccharomyces cerevisiae YPR173C VPS4 Defective in vacuolar protein sorting homologous to mouse SKD1 and to human hVPS4 AAA-type ATPase; AAA family ATPase VPS4 950630 2897125 KLLA0_B10846g Kluyveromyces lactis AAA family ATPase VPS4 XP_452011.1 949338 R 28985 CDS KLLA0_B10868g 2897051 complement(951111..952835) B 1 NC_006038.1 highly similar to uniprot|P49089 Saccharomyces cerevisiae YPR145W ASN1 Asparagine synthetase isozyme of Asn2p catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; asparagine synthase (glutamine-hydrolyzing) 1 952835 2897051 KLLA0_B10868g Kluyveromyces lactis asparagine synthase (glutamine-hydrolyzing) 1 XP_452012.1 951111 R 28985 CDS KLLA0_B10890g 2897315 954119..955684 B 1 NC_006038.1 similar to uniprot|Q06512 Saccharomyces cerevisiae YPR144C NOC4 Nucleolar protein forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits; ribosome biosynthesis protein NOC4 955684 2897315 KLLA0_B10890g Kluyveromyces lactis ribosome biosynthesis protein NOC4 XP_452013.1 954119 D 28985 CDS KLLA0_B10912g 2897136 955948..957486 B 1 NC_006038.1 similar to uniprot|P53043 Saccharomyces cerevisiae YGR123C; protein serine/threonine phosphatase 957486 2897136 KLLA0_B10912g Kluyveromyces lactis protein serine/threonine phosphatase XP_452014.1 955948 D 28985 CDS KLLA0_B10934g 2897175 complement(957643..958404) B 1 NC_006038.1 some similarities with gnl|GLV|CAGL0D05016g Candida glabrata CAGL0D05016g and some similarities with YPR143W uniprot|Q06511 Saccharomyces cerevisiae YPR143W RRP15 Essential protein involved in pre-rRNA processing; uncharacterized protein 958404 2897175 KLLA0_B10934g Kluyveromyces lactis uncharacterized protein XP_452015.1 957643 R 28985 CDS KLLA0_B10956g 2897518 958985..961057 B 1 NC_006038.1 similar to uniprot|P17119 Saccharomyces cerevisiae YPR141C KAR3 Minus-end-directed microtubule motor that functions in mitosis and meiosis localizes to the spindle pole body and localization is dependent on functional Cik1p required for nuclear fusion during mating potential Cdc28p substrate; uncharacterized protein 961057 2897518 KLLA0_B10956g Kluyveromyces lactis uncharacterized protein XP_452016.1 958985 D 28985 CDS KLLA0_B10978g 2897223 complement(961330..962553) B 1 NC_006038.1 similar to uniprot|Q6B2J1 Saccharomyces cerevisiae YPR140W; lysophosphatidylcholine acyltransferase 962553 2897223 KLLA0_B10978g Kluyveromyces lactis lysophosphatidylcholine acyltransferase XP_452017.1 961330 R 28985 CDS KLLA0_B11000g 2897316 962820..963674 B 1 NC_006038.1 similar to uniprot|Q06508 Saccharomyces cerevisiae YPR139C VPS66; lysophosphatidic acid acyltransferase LOA1 963674 2897316 KLLA0_B11000g Kluyveromyces lactis lysophosphatidic acid acyltransferase LOA1 XP_452018.1 962820 D 28985 CDS KLLA0_B11011g 2897241 complement(963671..964834) B 1 NC_006038.1 weakly similar to uniprot|P53272 Saccharomyces cerevisiae YGR122W; uncharacterized protein 964834 2897241 KLLA0_B11011g Kluyveromyces lactis uncharacterized protein XP_452019.1 963671 R 28985 CDS KLLA0_B11033g 2897222 966275..967636 B 1 NC_006038.1 similar to uniprot|P53390 Saccharomyces cerevisiae YPR138C MEP3 Ammonium permease of high capacity and low affinity belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+) expression is under the nitrogen catabolite repression regulation ammonia permease or uniprot|P40260 Saccharomyces cerevisiae YGR121C MEP1; ammonium permease MEP3 967636 2897222 KLLA0_B11033g Kluyveromyces lactis ammonium permease MEP3 XP_452020.1 966275 D 28985 CDS KLLA0_B11055g 2897352 969484..970302 B 1 NC_006038.1 some similarities with uniprot|Q12218 Saccharomyces cerevisiae YOR009W YOROO9W TIR4 protein; uncharacterized protein 970302 2897352 KLLA0_B11055g Kluyveromyces lactis uncharacterized protein XP_452021.1 969484 D 28985 CDS KLLA0_B11077g 2897237 complement(970761..972464) B 1 NC_006038.1 similar to uniprot|Q06506 Saccharomyces cerevisiae YPR137W RRP9 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); uncharacterized protein 972464 2897237 KLLA0_B11077g Kluyveromyces lactis uncharacterized protein XP_452022.1 970761 R 28985 CDS KLLA0_B11099g 2897342 complement(972830..975658) B 1 NC_006038.1 similar to uniprot|Q01454 Saccharomyces cerevisiae YPR135W CTF4 Chromatin-associated protein required for sister chromatid cohesion interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion; chromatin-binding protein CTF4 975658 2897342 KLLA0_B11099g Kluyveromyces lactis chromatin-binding protein CTF4 XP_452023.1 972830 R 28985 CDS KLLA0_B11121g 2897325 976252..976965 B 1 NC_006038.1 weakly similar to uniprot|P53271 Saccharomyces cerevisiae YGR120C COG2 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; Golgi transport complex subunit COG2 976965 2897325 KLLA0_B11121g Kluyveromyces lactis Golgi transport complex subunit COG2 XP_452024.1 976252 D 28985 CDS KLLA0_B11143g 2897368 977257..978972 B 1 NC_006038.1 some similarities with uniprot|P48837 Saccharomyces cerevisiae YGR119C NUP57 Essential subunit of the nuclear pore complex (NPC); FG-nucleoporin NUP57 978972 2897368 KLLA0_B11143g Kluyveromyces lactis FG-nucleoporin NUP57 XP_452025.1 977257 D 28985 CDS KLLA0_B11165g 2896986 complement(979154..979909) B 1 NC_006038.1 weakly similar to uniprot|P08593 YPR134W Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions; uncharacterized protein 979909 2896986 KLLA0_B11165g Kluyveromyces lactis uncharacterized protein XP_452026.1 979154 R 28985 CDS KLLA0_B11187g 2897083 complement(980285..980434) B 1 NC_006038.1 similar to uniprot|P80967 Saccharomyces cerevisiae YPR133W-A TOM5 Small mitochondrial outer membrane protein crucial to a binding relay for the import of proteins into mitochondria; subunit on the outer mouth of the TOM channel that accepts precursors from the receptors Tom20p and Tom22p; uncharacterized protein 980434 2897083 KLLA0_B11187g Kluyveromyces lactis uncharacterized protein XP_452027.1 980285 R 28985 CDS KLLA0_B11209g 2897071 980881..981969 B 1 NC_006038.1 similar to uniprot|Q06505 Saccharomyces cerevisiae YPR133C IWS1 Protein that interacts with Spt6p and copurifies with Spt5p and RNA polymerase II probable transcriptional elongation factor metazoan homologs contain an acidic N terminus mutations in the gene confer an Spt-phenotype; uncharacterized protein 981969 2897071 KLLA0_B11209g Kluyveromyces lactis uncharacterized protein XP_452028.1 980881 D 28985 CDS KLLA0_B11231g 2897150 complement(join(982256..982628,983249..983313)) B 1 NC_006038.1 uniprot|Q875M3 Kluyveromyces lactis KLLA0B11231g RPS23; 40S ribosomal protein uS12 983313 2897150 KLLA0_B11231g Kluyveromyces lactis 40S ribosomal protein uS12 XP_452029.1 982256 R 28985 CDS KLLA0_B11253g 2896937 984132..985544 B 1 NC_006038.1 similar to uniprot|P53270 Saccharomyces cerevisiae YGR117C; uncharacterized protein 985544 2896937 KLLA0_B11253g Kluyveromyces lactis uncharacterized protein XP_452030.1 984132 D 28985 CDS KLLA0_B11275g 2897392 985951..986544 B 1 NC_006038.1 similar to uniprot|Q06504 Saccharomyces cerevisiae YPR131C NAT3 Catalytic subunit of the NatB N-terminal acetyltransferase which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met; peptide alpha-N-acetyltransferase complex B subunit NAT3 986544 2897392 KLLA0_B11275g Kluyveromyces lactis peptide alpha-N-acetyltransferase complex B subunit NAT3 XP_452031.1 985951 D 28985 CDS KLLA0_B11297g 2896967 complement(986720..987610) B 1 NC_006038.1 some similarities with uniprot|P45978 Saccharomyces cerevisiae YPR129W SCD6 Protein containing an Lsm domain may bind RNA and have a role in RNA processing overproduction suppresses a null mutation in CHC1 which encodes the heavy chain of clathrin; uncharacterized protein 987610 2896967 KLLA0_B11297g Kluyveromyces lactis uncharacterized protein XP_452032.1 986720 R 28985 CDS KLLA0_B11319g 2897294 988293..989360 B 1 NC_006038.1 similar to uniprot|Q06497 Saccharomyces cerevisiae YPR128C ANT1 Peroxisomal adenine nucleotide transporter involved in beta-oxidation of medium-chain fatty acid required for peroxisome proliferation; uncharacterized protein 989360 2897294 KLLA0_B11319g Kluyveromyces lactis uncharacterized protein XP_452033.1 988293 D 28985 CDS KLLA0_B11341g 2897413 complement(989629..991008) B 1 NC_006038.1 similar to uniprot|P89103 Saccharomyces cerevisiae YPR125W; uncharacterized protein 991008 2897413 KLLA0_B11341g Kluyveromyces lactis uncharacterized protein XP_452034.1 989629 R 28985 CDS KLLA0_B11363g 2897225 complement(991730..992548) B 1 NC_006038.1 some similarities with uniprot|P40433 Saccharomyces cerevisiae YIL107C PFK26 6-phosphofructo-2-kinase; uncharacterized protein 992548 2897225 KLLA0_B11363g Kluyveromyces lactis uncharacterized protein XP_452035.1 991730 R 28985 CDS KLLA0_B11385g 2897509 complement(993418..997800) B 1 NC_006038.1 similar to uniprot|P23615 Saccharomyces cerevisiae YGR116W SPT6 Essential protein that interacts with histones and is involved in nucleosome disassembly and reassembly during transcription elongation; chromatin-remodeling histone chaperone SPT6 997800 2897509 KLLA0_B11385g Kluyveromyces lactis chromatin-remodeling histone chaperone SPT6 XP_452036.1 993418 R 28985 CDS KLLA0_B11407g 2897019 complement(998343..999251) B 1 NC_006038.1 similar to uniprot|Q75EP9 Ashbya gossypii AAR030W AAR030Wp and some similarites with YPR124W uniprot|P49573 Saccharomyces cerevisiae YPR124W CTR1 High-affinity copper transporter of the plasma membrane mediates nearly all copper uptake under low copper conditions transcriptionally induced at low copper levels and degraded at high copper levels; high-affinity Cu transporter CTR1 999251 2897019 KLLA0_B11407g Kluyveromyces lactis high-affinity Cu transporter CTR1 XP_452037.1 998343 R 28985 CDS KLLA0_B11429g 2896917 complement(999890..1000831) B 1 NC_006038.1 some similarities with uniprot|P53267 Saccharomyces cerevisiae YGR113W DAM1 Component of the DASH complex localized to intranuclear spindles and spindle pole bodies interacts with Duo1p and Mps1p key Ipl1p target for regulating kinetochore-microtubule attachments; uncharacterized protein 1000831 2896917 KLLA0_B11429g Kluyveromyces lactis uncharacterized protein XP_452038.1 999890 R 28985 CDS KLLA0_B11451g 2897111 complement(1001315..1002427) B 1 NC_006038.1 similar to uniprot|P53266 Saccharomyces cerevisiae YGR112W; uncharacterized protein 1002427 2897111 KLLA0_B11451g Kluyveromyces lactis uncharacterized protein XP_452039.1 1001315 R 28985 CDS KLLA0_B11473g 2897112 complement(1002808..1003692) B 1 NC_006038.1 similar to uniprot|P33759 Saccharomyces cerevisiae YBR251W MRPS5 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein uS5m 1003692 2897112 KLLA0_B11473g Kluyveromyces lactis mitochondrial 37S ribosomal protein uS5m XP_452040.1 1002808 R 28985 CDS KLLA0_B11495g 2897098 complement(1006306..1007487) B 1 NC_006038.1 similar to uniprot|P25042 Saccharomyces cerevisiae YPR065W ROX1 Heme-dependent repressor of hypoxic genes contains an HMG domain that is responsible for DNA bending activity; uncharacterized protein 1007487 2897098 KLLA0_B11495g Kluyveromyces lactis uncharacterized protein XP_452041.1 1006306 R 28985 CDS KLLA0_B11550g 2897417 complement(1013848..1014678) B 1 NC_006038.1 similar to gnl|GLV|CAGL0H09438g Candida glabrata CAGL0H09438g and weakly similar to YER016W uniprot|P40013 Saccharomyces cerevisiae YER016W BIM1 Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally; microtubule-binding protein BIM1 1014678 2897417 KLLA0_B11550g Kluyveromyces lactis microtubule-binding protein BIM1 XP_452044.1 1013848 R 28985 CDS KLLA0_B11572g 2897418 complement(1015091..1017328) B 1 NC_006038.1 similar to uniprot|P39518 Saccharomyces cerevisiae YER015W FAA2 Long chain fatty acyl-CoA synthetase accepts a wider range of acyl chain lengths than Faa1p preferring C9:0-C13:0 involved in the activation of endogenous pools of fatty acids; medium-chain fatty acid-CoA ligase FAA2 1017328 2897418 KLLA0_B11572g Kluyveromyces lactis medium-chain fatty acid-CoA ligase FAA2 XP_452045.1 1015091 R 28985 CDS KLLA0_B11594g 2896953 complement(1018044..1018388) B 1 NC_006038.1 similar to uniprot|P40567 Saccharomyces cerevisiae YIR009W MSL1 U2B component of U2 snRNP involved in splicing binds the U2 snRNA stem-loop IV in vitro does not contain the conserved C-terminal RNA binding domain found in other family members; U2 snRNP complex subunit MSL1 1018388 2896953 KLLA0_B11594g Kluyveromyces lactis U2 snRNP complex subunit MSL1 XP_452046.1 1018044 R 28985 CDS KLLA0_B11616g 2896901 complement(1018695..1020305) B 1 NC_006038.1 similar to uniprot|P40012 Saccharomyces cerevisiae YER014W HEM14 Protoporphyrinogen oxidase a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway converting protoporphyrinogen IX to protoporphyrin IX; oxygen-dependent protoporphyrinogen oxidase 1020305 2896901 KLLA0_B11616g Kluyveromyces lactis oxygen-dependent protoporphyrinogen oxidase XP_452047.1 1018695 R 28985 CDS KLLA0_B11638g 2897061 complement(1020591..1023926) B 1 NC_006038.1 similar to uniprot|P24384 Saccharomyces cerevisiae YER013W PRP22 RNA-dependent ATPase/ATP-dependent RNA helicase in the DEAH-box family associates with the lariat intermediate before the second catalytic step of splicing; DEAH-box ATP-dependent RNA helicase PRP22 1023926 2897061 KLLA0_B11638g Kluyveromyces lactis DEAH-box ATP-dependent RNA helicase PRP22 XP_452048.1 1020591 R 28985 CDS KLLA0_B11660g 2897371 complement(1024265..1024852) B 1 NC_006038.1 highly similar to uniprot|P22141 Saccharomyces cerevisiae YER012W PRE1 20S proteasome beta-type subunit localizes to the nucleus throughout the cell cycle; proteasome core particle subunit beta 4 1024852 2897371 KLLA0_B11660g Kluyveromyces lactis proteasome core particle subunit beta 4 XP_452049.1 1024265 R 28985 CDS KLLA0_B11682g 2897336 complement(1025244..1026554) B 1 NC_006038.1 highly similar to uniprot|P10363 Saccharomyces cerevisiae YIR008C PRI1 Subunit of DNA primase which is required for DNA synthesis and double-strand break repair; DNA primase subunit PRI1 1026554 2897336 KLLA0_B11682g Kluyveromyces lactis DNA primase subunit PRI1 XP_452050.1 1025244 R 28985 CDS KLLA0_B11704g 2897290 complement(1026886..1029105) B 1 NC_006038.1 similar to uniprot|P40566 Saccharomyces cerevisiae YIR007W; hydrolase 1029105 2897290 KLLA0_B11704g Kluyveromyces lactis hydrolase XP_452051.1 1026886 R 28985 CDS KLLA0_B11748g 2897469 complement(1030050..1031855) B 1 NC_006038.1 similar to uniprot|Q08179 Saccharomyces cerevisiae YOL027C MDM38 Mitochondrial Distribution and Morphology; ribosome-binding protein MDM38 1031855 2897469 KLLA0_B11748g Kluyveromyces lactis ribosome-binding protein MDM38 XP_452052.1 1030050 R 28985 CDS KLLA0_B11770g 2897153 1032369..1032998 B 1 NC_006038.1 weakly similar to uniprot|P40570 Saccharomyces cerevisiae YIR014W; uncharacterized protein 1032998 2897153 KLLA0_B11770g Kluyveromyces lactis uncharacterized protein XP_452053.1 1032369 D 28985 CDS KLLA0_B11792g 2897408 1033135..1033698 B 1 NC_006038.1 similar to uniprot|P40571 Saccharomyces cerevisiae YIR015W RPR2 Subunit of nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends not shared between Rnase MRP and Rnase P in contrast to all other Rnase P protein subunits; ribonuclease P protein subunit RPR2 1033698 2897408 KLLA0_B11792g Kluyveromyces lactis ribonuclease P protein subunit RPR2 XP_452054.1 1033135 D 28985 CDS KLLA0_B11814g 2896920 complement(1033801..1034298) B 1 NC_006038.1 some similarities with uniprot|Q08176 Saccharomyces cerevisiae YOL026C MIM1 Mitochondrial outer membrane protein that mediates assembly of mitochondrial beta-barrel proteins also proposed to be involved in mitochondrial import; uncharacterized protein 1034298 2896920 KLLA0_B11814g Kluyveromyces lactis uncharacterized protein XP_452055.1 1033801 R 28985 CDS KLLA0_B11836g 2896890 1034800..1035564 B 1 NC_006038.1 highly similar to uniprot|P40303 Saccharomyces cerevisiae YOL038W PRE6 20S proteasome alpha-type subunit; proteasome core particle subunit alpha 4 1035564 2896890 KLLA0_B11836g Kluyveromyces lactis proteasome core particle subunit alpha 4 XP_452056.1 1034800 D 28985 CDS KLLA0_B11858g 2896908 1036159..1038522 B 1 NC_006038.1 weakly similar to uniprot|Q08206 Saccharomyces cerevisiae YOL036W Protein of unknown function potential Cdc28p substrate; uncharacterized protein 1038522 2896908 KLLA0_B11858g Kluyveromyces lactis uncharacterized protein XP_452057.1 1036159 D 28985 CDS KLLA0_B11880g 2896909 complement(1039145..1040059) B 1 NC_006038.1 weakly similar to uniprot|P40573 Saccharomyces cerevisiae YIR017C MET28 Transcriptional activator in the Cbf1p-Met4p-Met28p complex participates in the regulation of sulfur metabolism; uncharacterized protein 1040059 2896909 KLLA0_B11880g Kluyveromyces lactis uncharacterized protein XP_452058.1 1039145 R 28985 CDS KLLA0_B11902g 2897357 1041657..1043144 B 1 NC_006038.1 uniprot|Q9P8P0 Kluyveromyces lactis MPK1 MAP kinase; mitogen-activated serine/threonine-protein kinase SLT2 1043144 2897357 KLLA0_B11902g Kluyveromyces lactis mitogen-activated serine/threonine-protein kinase SLT2 XP_452059.1 1041657 D 28985 CDS KLLA0_B11924g 2897070 complement(1043344..1047582) B 1 NC_006038.1 similar to uniprot|P22219 Saccharomyces cerevisiae YBR097W VPS15 Myristoylated Serine/threonine protein kinase involved in vacuolar protein sorting; ubiquitin-binding serine/threonine protein kinase VPS15 1047582 2897070 KLLA0_B11924g Kluyveromyces lactis ubiquitin-binding serine/threonine protein kinase VPS15 XP_452060.1 1043344 R 28985 CDS KLLA0_B11946g 2896977 complement(1048033..1049352) B 1 NC_006038.1 similar to uniprot|P41808 Saccharomyces cerevisiae YPR054W SMK1 Mitogen-activated protein kinase required for spore morphogenesis that is expressed as a middle sporulation-specific gene; mitogen-activated protein kinase SMK1 1049352 2896977 KLLA0_B11946g Kluyveromyces lactis mitogen-activated protein kinase SMK1 XP_452061.1 1048033 R 28985 CDS KLLA0_B11968g 2897341 complement(1049643..1050335) B 1 NC_006038.1 similar to uniprot|P38256 Saccharomyces cerevisiae YBR096W; uncharacterized protein 1050335 2897341 KLLA0_B11968g Kluyveromyces lactis uncharacterized protein XP_452062.1 1049643 R 28985 CDS KLLA0_B11990g 2897039 1050943..1052043 B 1 NC_006038.1 similar to uniprot|P38255 Saccharomyces cerevisiae YBR095C RXT2; uncharacterized protein 1052043 2897039 KLLA0_B11990g Kluyveromyces lactis uncharacterized protein XP_452063.1 1050943 D 28985 CDS KLLA0_B12012g 2897040 complement(1052188..1054341) B 1 NC_006038.1 similar to uniprot|P38254 Saccharomyces cerevisiae YBR094W; uncharacterized protein 1054341 2897040 KLLA0_B12012g Kluyveromyces lactis uncharacterized protein XP_452064.1 1052188 R 28985 CDS KLLA0_B12034g 2897159 1054622..1054981 B 1 NC_006038.1 similar to uniprot|P32830 Saccharomyces cerevisiae YBR091C MRS5 Essential protein of the inner mitochondrial membrane peripherally localized component of the TIM22 complex which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins; uncharacterized protein 1054981 2897159 KLLA0_B12034g Kluyveromyces lactis uncharacterized protein XP_452065.1 1054622 D 28985 CDS KLLA0_B12056g 2897282 1056188..1056469 B 1 NC_006038.1 highly similar to uniprot|P11632 Saccharomyces cerevisiae YPR052C NHP6A High-mobility group non-histone chromatin protein functionally redundant with Nhp6Bp homologous to mammalian high mobility group proteins 1 and 2 acts to recruit transcription factor Rcs1p to certain promoters; high-mobility group nucleosome-binding protein 1056469 2897282 KLLA0_B12056g Kluyveromyces lactis high-mobility group nucleosome-binding protein XP_452066.1 1056188 D 28985 CDS KLLA0_B12078g 2896921 1056994..1057770 B 1 NC_006038.1 highly similar to uniprot|P15873 Saccharomyces cerevisiae YBR088C POL30 Proliferating cell nuclear antigen (PCNA) functions as the sliding clamp for DNA polymerase delta may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair; proliferating cell nuclear antigen 1057770 2896921 KLLA0_B12078g Kluyveromyces lactis proliferating cell nuclear antigen XP_452067.1 1056994 D 28985 CDS KLLA0_B12100g 2897363 complement(1057857..1058393) B 1 NC_006038.1 highly similar to uniprot|Q75B80 Ashbya gossypii ADL308C ADL308Cp and similar to uniprot|Q03503 Saccharomyces cerevisiae YPR051W MAK3 Catalytic subunit of N-terminal acetyltransferase of the NatC type required for replication of dsRNA virus; peptide alpha-N-acetyltransferase MAK3 1058393 2897363 KLLA0_B12100g Kluyveromyces lactis peptide alpha-N-acetyltransferase MAK3 XP_452068.1 1057857 R 28985 CDS KLLA0_B12133g 2897251 1058858..1061998 B 1 NC_006038.1 similar to uniprot|Q12527 Saccharomyces cerevisiae YPR049C ATG11 Peripheral membrane protein required for delivery of aminopeptidase I (Lap4p) to the vacuole in the cytoplasm- to-vacuole targeting pathway also required for peroxisomal degradation (pexophagy); autophagy protein ATG11 1061998 2897251 KLLA0_B12133g Kluyveromyces lactis autophagy protein ATG11 XP_452070.1 1058858 D 28985 CDS KLLA0_B12155g 2897252 complement(1062000..1063874) B 1 NC_006038.1 similar to uniprot|Q12181 Saccharomyces cerevisiae YPR048W TAH18 Protein with a potential role in DNA replication displays synthetic lethal genetic interaction with the pol3-13 allele of POL3 which encodes DNA polymerase delta; NAPDH-dependent diflavin reductase 1063874 2897252 KLLA0_B12155g Kluyveromyces lactis NAPDH-dependent diflavin reductase XP_452071.1 1062000 R 28985 CDS KLLA0_B12177g 2897087 complement(1064233..1065621) B 1 NC_006038.1 similar to uniprot|P08425 Saccharomyces cerevisiae YPR047W; phenylalanine--tRNA ligase 1065621 2897087 KLLA0_B12177g Kluyveromyces lactis phenylalanine--tRNA ligase XP_452072.1 1064233 R 28985 CDS KLLA0_B12199g 2897301 1065991..1066656 B 1 NC_006038.1 highly similar to uniprot|P38064 Saccharomyces cerevisiae YBL038W MRPL16 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein uL16m 1066656 2897301 KLLA0_B12199g Kluyveromyces lactis mitochondrial 54S ribosomal protein uL16m XP_452073.1 1065991 D 28985 CDS KLLA0_B12221g 2897168 complement(1066808..1067875) B 1 NC_006038.1 highly similar to uniprot|P38251 Saccharomyces cerevisiae YBR087W RFC5 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; replication factor C subunit 5 1067875 2897168 KLLA0_B12221g Kluyveromyces lactis replication factor C subunit 5 XP_452074.1 1066808 R 28985 CDS KLLA0_B12243g 2896902 1068225..1071083 B 1 NC_006038.1 similar to uniprot|P38065 Saccharomyces cerevisiae YBL037W APL3 clathrin Associated Protein complex Large subunit Large subunit of clathrin associated protein complex; uncharacterized protein 1071083 2896902 KLLA0_B12243g Kluyveromyces lactis uncharacterized protein XP_452075.1 1068225 D 28985 CDS KLLA0_B12265g 2896981 complement(1071265..1072041) B 1 NC_006038.1 highly similar to uniprot|P38197 Saccharomyces cerevisiae YBL036C Single-domain racemase possibly non-specific due to the lack of the second domain which presumably determines specificity; uncharacterized protein 1072041 2896981 KLLA0_B12265g Kluyveromyces lactis uncharacterized protein XP_452076.1 1071265 R 28985 CDS KLLA0_B12287g 2897453 1072379..1074952 B 1 NC_006038.1 weakly similar to uniprot|P38250 Saccharomyces cerevisiae YBR086C IST2; uncharacterized protein 1074952 2897453 KLLA0_B12287g Kluyveromyces lactis uncharacterized protein XP_452077.1 1072379 D 28985 CDS KLLA0_B12309g 2897454 complement(1075035..1076984) B 1 NC_006038.1 similar to uniprot|P38121 Saccharomyces cerevisiae YBL035C POL12 Subunit of the DNA polymerase alpha-primase complex required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis; DNA-directed DNA polymerase alpha subunit POL12 1076984 2897454 KLLA0_B12309g Kluyveromyces lactis DNA-directed DNA polymerase alpha subunit POL12 XP_452078.1 1075035 R 28985 CDS KLLA0_B12331g 2897534 complement(1077179..1081255) B 1 NC_006038.1 weakly similar to uniprot|P38198 Saccharomyces cerevisiae YBL034C STU1 Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p) required for interpolar microtubules to provide an outward force on the spindle poles; uncharacterized protein 1081255 2897534 KLLA0_B12331g Kluyveromyces lactis uncharacterized protein XP_452079.1 1077179 R 28985 CDS KLLA0_B12353g 2897079 1082023..1082277 B 1 NC_006038.1 similar to uniprot|O43137 Saccharomyces cerevisiae YBR085C-A; uncharacterized protein 1082277 2897079 KLLA0_B12353g Kluyveromyces lactis uncharacterized protein XP_452080.1 1082023 D 28985 CDS KLLA0_B12375g 2896868 complement(1082452..1083366) B 1 NC_006038.1 similar to uniprot|P38066 Saccharomyces cerevisiae YBL033C RIB1 GTP cyclohydrolase II catalyzes the first step of the riboflavin biosynthesis pathway; GTP cyclohydrolase II 1083366 2896868 KLLA0_B12375g Kluyveromyces lactis GTP cyclohydrolase II XP_452081.1 1082452 R 28985 CDS KLLA0_B12397g 2897324 complement(1084129..1086468) B 1 NC_006038.1 similar to uniprot|P35999 Saccharomyces cerevisiae YKL134C OCT1 Mitochondrial intermediate peptidase cleaves N-terminal residues of a subset of proteins upon import after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p) may contribute to mitochondrial iron homeostasis; metalloendopeptidase 1086468 2897324 KLLA0_B12397g Kluyveromyces lactis metalloendopeptidase XP_452082.1 1084129 R 28985 CDS KLLA0_B12419g 2897172 complement(1086792..1088291) B 1 NC_006038.1 similar to uniprot|Q04472 Saccharomyces cerevisiae YMR115W FMP24 The authentic non-tagged protein was localized to the mitochondria; uncharacterized protein 1088291 2897172 KLLA0_B12419g Kluyveromyces lactis uncharacterized protein XP_452083.1 1086792 R 28985 CDS KLLA0_B12441g 2897184 1088719..1089669 B 1 NC_006038.1 weakly similar to uniprot|Q04471 Saccharomyces cerevisiae YMR114C; uncharacterized protein 1089669 2897184 KLLA0_B12441g Kluyveromyces lactis uncharacterized protein XP_452084.1 1088719 D 28985 CDS KLLA0_B12463g 2897185 complement(1089742..1091010) B 1 NC_006038.1 similar to uniprot|Q12676 Saccharomyces cerevisiae YMR113W FOL3 Dihydrofolate synthetase involved in folic acid biosynthesis catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis; dihydrofolate synthase 1091010 2897185 KLLA0_B12463g Kluyveromyces lactis dihydrofolate synthase XP_452085.1 1089742 R 28985 CDS KLLA0_B12496g 2897096 1091875..1093158 B 1 NC_006038.1 weakly similar to uniprot|Q04461 Saccharomyces cerevisiae YMR111C; uncharacterized protein 1093158 2897096 KLLA0_B12496g Kluyveromyces lactis uncharacterized protein XP_452087.1 1091875 D 28985 CDS KLLA0_B12518g 2897466 complement(1093257..1093982) B 1 NC_006038.1 similar to uniprot|P36068 Saccharomyces cerevisiae YKL130C SHE2 RNA-binding protein that binds specific mRNAs and interacts with She3p part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; uncharacterized protein 1093982 2897466 KLLA0_B12518g Kluyveromyces lactis uncharacterized protein XP_452088.1 1093257 R 28985 CDS KLLA0_B12540g 2897304 1094239..1095804 B 1 NC_006038.1 similar to uniprot|Q04458 Saccharomyces cerevisiae YMR110C; hexadecenal dehydrogenase 1095804 2897304 KLLA0_B12540g Kluyveromyces lactis hexadecenal dehydrogenase XP_452089.1 1094239 D 28985 CDS KLLA0_B12562g 2897213 complement(1095953..1099735) B 1 NC_006038.1 similar to uniprot|Q04439 Saccharomyces cerevisiae YMR109W MYO5 One of two type I myosins contains proline-rich tail homology 2 (TH2) and SH3 domains MYO5 deletion has little effect on growth but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization and to uniprot|P36006 Saccharomyces cerevisiae YKL129C MYO3; uncharacterized protein 1099735 2897213 KLLA0_B12562g Kluyveromyces lactis uncharacterized protein XP_452090.1 1095953 R 28985 CDS KLLA0_B12584g 2897214 complement(1100489..1102564) B 1 NC_006038.1 highly similar to uniprot|P07342 Saccharomyces cerevisiae YMR108W ILV2 Acetolactate synthase catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors localizes to the mitochondria expression of the gene is under general amino acid control; acetolactate synthase catalytic subunit 1102564 2897214 KLLA0_B12584g Kluyveromyces lactis acetolactate synthase catalytic subunit XP_452091.1 1100489 R 28985 CDS KLLA0_B12606g 2897353 complement(1102700..1103167) B 1 NC_006038.1 no similarity; uncharacterized protein 1103167 2897353 KLLA0_B12606g Kluyveromyces lactis uncharacterized protein XP_452092.1 1102700 R 28985 CDS KLLA0_B12628g 2897100 complement(1103388..1104254) B 1 NC_006038.1 similar to uniprot|P36069 Saccharomyces cerevisiae YKL128C PMU1 Phospho MUtase homolog. Small region homologous to active site of phospho-mutases these move phosphates via a phospho-histidine intermediate. Homologs include: Sc GPM1 bact. Pgm Hs Bpgm & rat fructose-2 6-bisphosphatase Phospo-mutase homolog; uncharacterized protein 1104254 2897100 KLLA0_B12628g Kluyveromyces lactis uncharacterized protein XP_452093.1 1103388 R 28985 CDS KLLA0_B12650g 2896984 complement(1104366..1104749) B 1 NC_006038.1 similar to uniprot|Q04438 Saccharomyces cerevisiae YMR107W SPG4 Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; uncharacterized protein 1104749 2896984 KLLA0_B12650g Kluyveromyces lactis uncharacterized protein XP_452094.1 1104366 R 28985 CDS KLLA0_B12672g 2897009 1105330..1107159 B 1 NC_006038.1 uniprot|Q6XCY9 Kluyveromyces lactis KU80 Ku80p; ATP-dependent DNA helicase YKU80 1107159 2897009 KLLA0_B12672g Kluyveromyces lactis ATP-dependent DNA helicase YKU80 XP_452095.1 1105330 D 28985 CDS KLLA0_B12694g 2897242 1107696..1109402 B 1 NC_006038.1 highly similar to uniprot|P37012 Saccharomyces cerevisiae YMR105C PGM2 Phosphoglucomutase catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate which is a key step in hexose metabolism functions as the acceptor for a Glc-phosphotransferase and to YKL127W uniprot|P33401 Saccharomyces cerevisiae YKL127W PGM1 Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6- phosphate, which is a key step in hexose metabolism; uncharacterized protein 1109402 2897242 KLLA0_B12694g Kluyveromyces lactis uncharacterized protein XP_452096.1 1107696 D 28985 CDS KLLA0_B12716g 2897243 1109939..1112089 B 1 NC_006038.1 similar to uniprot|P12688 Saccharomyces cerevisiae YKL126W YPK1 and similar to uniprot|P18961 Saccharomyces cerevisiae YMR104C YPK2 serine/threonine protein kinase; serine/threonine protein kinase YPK1 1112089 2897243 KLLA0_B12716g Kluyveromyces lactis serine/threonine protein kinase YPK1 XP_452097.1 1109939 D 28985 CDS KLLA0_B12738g 2897280 1112500..1114476 B 1 NC_006038.1 some similarities with uniprot|P36070 Saccharomyces cerevisiae YKL125W RRN3 Required for transcription of rDNA by RNA Polymerase I DNA-independent RNA Polymerase I transcription factor; rDNA-binding RNA polymerase I transcriptional factor 1114476 2897280 KLLA0_B12738g Kluyveromyces lactis rDNA-binding RNA polymerase I transcriptional factor XP_452098.1 1112500 D 28985 CDS KLLA0_B12760g 2896944 1114942..1116570 B 1 NC_006038.1 similar to uniprot|P32343 Saccharomyces cerevisiae YKL124W SSH4 Suppressor of SHR3 confers leflunomide resistance when overexpressed (putative) involved in ER functions; uncharacterized protein 1116570 2896944 KLLA0_B12760g Kluyveromyces lactis uncharacterized protein XP_452099.1 1114942 D 28985 CDS KLLA0_B12782g 2897467 complement(1116729..1117160) B 1 NC_006038.1 similar to uniprot|P32342 Saccharomyces cerevisiae YKL122C SRP21 Component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane; signal recognition particle subunit SRP21 1117160 2897467 KLLA0_B12782g Kluyveromyces lactis signal recognition particle subunit SRP21 XP_452100.1 1116729 R 28985 CDS KLLA0_B12804g 2896993 1117475..1120033 B 1 NC_006038.1 similar to uniprot|Q03177 Saccharomyces cerevisiae YMR102C Protein of unknown function transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; uncharacterized protein 1120033 2896993 KLLA0_B12804g Kluyveromyces lactis uncharacterized protein XP_452101.1 1117475 D 28985 CDS KLLA0_B12826g 2897440 1121106..1122065 B 1 NC_006038.1 similar to uniprot|P32332 Saccharomyces cerevisiae YKL120W OAC1 Mitochondrial inner membrane transporter transports oxaloacetate sulfate and thiosulfate member of the mitochondrial carrier family; uncharacterized protein 1122065 2897440 KLLA0_B12826g Kluyveromyces lactis uncharacterized protein XP_452102.1 1121106 D 28985 CDS KLLA0_B12848g 2897441 1122397..1123482 B 1 NC_006038.1 similar to uniprot|Q03175 Saccharomyces cerevisiae YMR101C SRT1 Cis-prenyltransferase involved in dolichol synthesis and weakly similar to YBR002C uniprot|P35196 Saccharomyces cerevisiae YBR002C RER2 Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting; ditrans,polycis-polyprenyl diphosphate synthase 1123482 2897441 KLLA0_B12848g Kluyveromyces lactis ditrans,polycis-polyprenyl diphosphate synthase XP_452103.1 1122397 D 28985 CDS KLLA0_B12870g 2896982 complement(1123581..1124198) B 1 NC_006038.1 weakly similar to uniprot|P32341 Saccharomyces cerevisiae YKL119C VPH2 Protein involved in vacuolar H - ATPase assembly or function required for the biogenesis of a functional vacuolar ATPase (V-ATPase) but not part of the final enzyme complex; uncharacterized protein 1124198 2896982 KLLA0_B12870g Kluyveromyces lactis uncharacterized protein XP_452104.1 1123581 R 28985 CDS KLLA0_B12892g 2897090 1124666..1126543 B 1 NC_006038.1 similar to uniprot|Q03162 Saccharomyces cerevisiae YMR100W; uncharacterized protein 1126543 2897090 KLLA0_B12892g Kluyveromyces lactis uncharacterized protein XP_452105.1 1124666 D 28985 CDS KLLA0_B12914g 2897074 1126975..1128255 B 1 NC_006038.1 similar to uniprot|P53264 Saccharomyces cerevisiae YGR110W; carboxylic ester hydrolase 1128255 2897074 KLLA0_B12914g Kluyveromyces lactis carboxylic ester hydrolase XP_452106.1 1126975 D 28985 CDS KLLA0_B12936g 2897105 complement(1128687..1130792) B 1 NC_006038.1 similar to uniprot|P30624 Saccharomyces cerevisiae YOR317W FAA1 Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids involved in the activation of imported fatty acids not required for growth on nonfermentable carbon sources essential for stationary phase and similar to YMR246W uniprot|P47912 Saccharomyces cerevisiae YMR246W FAA4 Long chain fatty acyl-CoA synthetase and similar to YIL009W uniprot|P39002 Saccharomyces cerevisiae YIL009W FAA3 Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; long-chain fatty acid-CoA ligase FAA1 1130792 2897105 KLLA0_B12936g Kluyveromyces lactis long-chain fatty acid-CoA ligase FAA1 XP_452107.1 1128687 R 28985 CDS KLLA0_B12958g 2897106 complement(1131377..1132489) B 1 NC_006038.1 weakly similar to uniprot|Q04740 Saccharomyces cerevisiae YMR234W RNH1 Ribonuclease H1 removes RNA primers during Okazaki fragment synthesis degrades RNA attached to the 5'-end of a DNA strand; RNA-DNA hybrid ribonuclease 1132489 2897106 KLLA0_B12958g Kluyveromyces lactis RNA-DNA hybrid ribonuclease XP_452108.1 1131377 R 28985 CDS KLLA0_B12980g 2897231 complement(1132843..1133715) B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 1133715 2897231 KLLA0_B12980g Kluyveromyces lactis uncharacterized protein XP_452109.1 1132843 R 28985 CDS KLLA0_B13002g 2896991 complement(1134173..1138306) B 1 NC_006038.1 weakly similar to uniprot|Q08748 Saccharomyces cerevisiae YOR296W; uncharacterized protein 1138306 2896991 KLLA0_B13002g Kluyveromyces lactis uncharacterized protein XP_452110.1 1134173 R 28985 CDS KLLA0_B13024g 2897520 complement(1138572..1138946) B 1 NC_006038.1 similar to uniprot|Q05024 Saccharomyces cerevisiae YMR233W Interacts with Top1p in 2-hybrid assay; uncharacterized protein 1138946 2897520 KLLA0_B13024g Kluyveromyces lactis uncharacterized protein XP_452111.1 1138572 R 28985 CDS KLLA0_B13046g 2897265 complement(1139556..1140170) B 1 NC_006038.1 similar to uniprot|Q08746 Saccharomyces cerevisiae YOR294W RRS1 Essential protein that binds ribosomal protein L11 and is required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis mouse homolog shows altered expression in Huntington's disease model mice; uncharacterized protein 1140170 2897265 KLLA0_B13046g Kluyveromyces lactis uncharacterized protein XP_452112.1 1139556 R 28985 CDS KLLA0_B13068g 2897438 complement(1140423..1142438) B 1 NC_006038.1 some similarities with uniprot|Q05670 Saccharomyces cerevisiae YMR232W FUS2 Cytoplasmic protein localized to the shmoo tip required for the alignment of parental nuclei before nuclear fusion during mating; uncharacterized protein 1142438 2897438 KLLA0_B13068g Kluyveromyces lactis uncharacterized protein XP_452113.1 1140423 R 28985 CDS KLLA0_B13090g 2897439 complement(1142698..1145763) B 1 NC_006038.1 similar to uniprot|P12868 Saccharomyces cerevisiae YMR231W PEP5 Peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis forms complex with Pep3p that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins also interacts with Pep7p; tethering complex subunit PEP5 1145763 2897439 KLLA0_B13090g Kluyveromyces lactis tethering complex subunit PEP5 XP_452114.1 1142698 R 28985 CDS KLLA0_B13112g 2897091 complement(1146006..1148198) B 1 NC_006038.1 similar to uniprot|P23561 Saccharomyces cerevisiae YLR362W STE11 Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p and the high osmolarity response pathway via phosphorylation of Pbs2p regulated by Ste20p and Ste50p; mitogen-activated protein kinase kinase kinase STE11 1148198 2897091 KLLA0_B13112g Kluyveromyces lactis mitogen-activated protein kinase kinase kinase STE11 XP_452115.1 1146006 R 28985 CDS KLLA0_B13123g 9487507 1148510..1148791 B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 1148791 9487507 KLLA0_B13123g Kluyveromyces lactis uncharacterized protein XP_002999356.1 1148510 D 28985 CDS KLLA0_B13134g 2897542 1149114..1150811 B 1 NC_006038.1 similar to uniprot|Q05924 Saccharomyces cerevisiae YLR361C DCR2 Protein involved in cell cycle regulation; phosphoprotein phosphatase 1150811 2897542 KLLA0_B13134g Kluyveromyces lactis phosphoprotein phosphatase XP_452116.1 1149114 D 28985 CDS KLLA0_B13145g 2897014 complement(1150783..1151790) B 1 NC_006038.1 weakly similar to uniprot|Q6B1J7 Saccharomyces cerevisiae YLR360W VPS38 involved in vacuolar protein targeting; uncharacterized protein 1151790 2897014 KLLA0_B13145g Kluyveromyces lactis uncharacterized protein XP_452117.1 1150783 R 28985 CDS KLLA0_B13167g 2897030 1152802..1153566 B 1 NC_006038.1 similar to uniprot|P53237 Saccharomyces cerevisiae YGR057C LST7 Protein possibly involved in a post-Golgi secretory pathway required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface; uncharacterized protein 1153566 2897030 KLLA0_B13167g Kluyveromyces lactis uncharacterized protein XP_452118.1 1152802 D 28985 CDS KLLA0_B13189g 2897031 complement(1153780..1155228) B 1 NC_006038.1 highly similar to uniprot|Q05911 Saccharomyces cerevisiae YLR359W ADE13 Adenylosuccinate lyase catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; adenylosuccinase ADE13 1155228 2897031 KLLA0_B13189g Kluyveromyces lactis adenylosuccinase ADE13 XP_452119.1 1153780 R 28985 CDS KLLA0_B13211g 2897045 complement(1155757..1158504) B 1 NC_006038.1 similar to uniprot|Q06488 Saccharomyces cerevisiae YLR357W RSC2 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex required for expression of mid-late sporulation-specific genes contains two essential bromodomains a bromo-adjacent homology (BAH) domain and an AT hook; uncharacterized protein 1158504 2897045 KLLA0_B13211g Kluyveromyces lactis uncharacterized protein XP_452120.1 1155757 R 28985 CDS KLLA0_B13233g 2897160 complement(1159097..1160833) B 1 NC_006038.1 highly similar to uniprot|P50276 Saccharomyces cerevisiae YGR055W MUP1 High affinity methionine permease integral membrane protein with 13 putative membrane-spanning regions also involved in cysteine uptake; uncharacterized protein 1160833 2897160 KLLA0_B13233g Kluyveromyces lactis uncharacterized protein XP_452121.1 1159097 R 28985 CDS KLLA0_B13255g 2897355 complement(1162142..1163938) B 1 NC_006038.1 highly similar to uniprot|P29468 Saccharomyces cerevisiae YKR002W PAP1 Poly(A) polymerase one of three factors required for mRNA 3'-end polyadenylation forms multiprotein complex with polyadenylation factor I (PF I) also required for mRNA nuclear export may also polyadenylate rRNAs; polynucleotide adenylyltransferase PAP1 1163938 2897355 KLLA0_B13255g Kluyveromyces lactis polynucleotide adenylyltransferase PAP1 XP_452122.1 1162142 R 28985 CDS KLLA0_B13277g 2896988 1165743..1167797 B 1 NC_006038.1 highly similar to uniprot|P21576 Saccharomyces cerevisiae YKR001C VPS1 GTPase required for vacuolar protein sorting, functions in actin cytoskeleton organization via its interaction with Sla1p; dynamin-like GTPase VPS1 1167797 2896988 KLLA0_B13277g Kluyveromyces lactis dynamin-like GTPase VPS1 XP_452123.1 1165743 D 28985 CDS KLLA0_B13321g 2897073 1169757..1170353 B 1 NC_006038.1 highly similar to uniprot|Q02196 Saccharomyces cerevisiae YKL001C MET14 Adenylylsulfate kinase required for sulfate assimilation and involved in methionine metabolism; adenylyl-sulfate kinase 1170353 2897073 KLLA0_B13321g Kluyveromyces lactis adenylyl-sulfate kinase XP_452124.1 1169757 D 28985 CDS KLLA0_B13343g 2897162 complement(join(1170477..1171127,1171345..1171404)) B 1 NC_006038.1 similar to uniprot|P36108 Saccharomyces cerevisiae YKL002W DID4 Class E Vps protein of the ESCRT-III complex required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies and for delivery of newly synthesized vacuolar enzymes to the vacuole involved in endocytosis; ESCRT-III subunit protein DID4 1171404 2897162 KLLA0_B13343g Kluyveromyces lactis ESCRT-III subunit protein DID4 XP_452125.1 1170477 R 28985 CDS KLLA0_B13365g 2897210 1171833..1172222 B 1 NC_006038.1 similar to uniprot|P28778 Saccharomyces cerevisiae YKL003C MRP17 Mitochondrial ribosomal protein of the small subunit MRP17 exhibits genetic interactions with PET122 encoding a COX3-specific translational activator; mitochondrial 37S ribosomal protein bS6m 1172222 2897210 KLLA0_B13365g Kluyveromyces lactis mitochondrial 37S ribosomal protein bS6m XP_452126.1 1171833 D 28985 CDS KLLA0_B13387g 2897263 complement(1172683..1173948) B 1 NC_006038.1 similar to uniprot|P36107 Saccharomyces cerevisiae YKL004W AUR1 Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase) required for sphingolipid synthesis can mutate to confer aureobasidin A resistance; inositol phosphorylceramide synthase 1173948 2897263 KLLA0_B13387g Kluyveromyces lactis inositol phosphorylceramide synthase XP_452127.1 1172683 R 28985 CDS KLLA0_B13409g 2897264 complement(join(1174802..1175089,1175553..1175681)) B 1 NC_006038.1 highly similar to uniprot|P36105 Saccharomyces cerevisiae YKL006W RPL14A and to uniprot|P38754 Saccharomyces cerevisiae YHL001W RPL14B Protein component of the large (60S) ribosomal subunit; 60S ribosomal protein eL14 1175681 2897264 KLLA0_B13409g Kluyveromyces lactis 60S ribosomal protein eL14 XP_452128.1 1174802 R 28985 CDS KLLA0_B13431g 2897314 join(1177099..1177134,1177272..1177529) B 1 NC_006038.1 highly similar to uniprot|P43682 Saccharomyces cerevisiae YKL006C-A SFT1 Intra-Golgi v-SNARE required for transport of proteins between an early and a later Golgi compartment; uncharacterized protein 1177529 2897314 KLLA0_B13431g Kluyveromyces lactis uncharacterized protein XP_452129.1 1177099 D 28985 CDS KLLA0_B13453g 2897530 complement(1177655..1178443) B 1 NC_006038.1 uniprot|O74232 Kluyveromyces lactis CAP1 CAPZA F-actin capping protein alpha subunit; uncharacterized protein 1178443 2897530 KLLA0_B13453g Kluyveromyces lactis uncharacterized protein XP_452130.1 1177655 R 28985 CDS KLLA0_B13475g 2897411 complement(1178856..1180382) B 1 NC_006038.1 similar to uniprot|P38753 Saccharomyces cerevisiae YHL002W HSE1 Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes; ESCRT-0 subunit protein HSE1 1180382 2897411 KLLA0_B13475g Kluyveromyces lactis ESCRT-0 subunit protein HSE1 XP_452131.1 1178856 R 28985 CDS KLLA0_B13497g 2897412 1181036..1182262 B 1 NC_006038.1 similar to uniprot|P28496 Saccharomyces cerevisiae YKL008C LAC1 Ceramide synthase component involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine functionally equivalent to Lag1p and similar to YHL003C uniprot|P38703 Saccharomyces cerevisiae YHL003C LAG1 Ceramide synthase component involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine functionally equivalent to Lac1p; uncharacterized protein 1182262 2897412 KLLA0_B13497g Kluyveromyces lactis uncharacterized protein XP_452132.1 1181036 D 28985 CDS KLLA0_B13519g 2897367 complement(1182602..1183822) B 1 NC_006038.1 similar to uniprot|P32902 Saccharomyces cerevisiae YHL004W MRP4 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein uS2m 1183822 2897367 KLLA0_B13519g Kluyveromyces lactis mitochondrial 37S ribosomal protein uS2m XP_452133.1 1182602 R 28985 CDS KLLA0_B13541g 2896959 1184200..1184715 B 1 NC_006038.1 similar to uniprot|P38751 Saccharomyces cerevisiae YHL006C SHU1 Protein involved in recombination; uncharacterized protein 1184715 2896959 KLLA0_B13541g Kluyveromyces lactis uncharacterized protein XP_452134.1 1184200 D 28985 CDS KLLA0_B13563g 2896972 complement(1184809..1185525) B 1 NC_006038.1 highly similar to uniprot|P33201 Saccharomyces cerevisiae YKL009W MRT4 Protein involved in mRNA turnover and ribosome assembly localizes to the nucleolus; mRNA turnover protein MRT4 1185525 2896972 KLLA0_B13563g Kluyveromyces lactis mRNA turnover protein MRT4 XP_452135.1 1184809 R 28985 CDS KLLA0_B13585g 2896973 1186427..1190830 B 1 NC_006038.1 similar to uniprot|P33202 Saccharomyces cerevisiae YKL010C UFD4 Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p two subunits of the 19S particle of the 26S proteasome cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; uncharacterized protein 1190830 2896973 KLLA0_B13585g Kluyveromyces lactis uncharacterized protein XP_452136.1 1186427 D 28985 CDS KLLA0_B13607g 2897018 1191592..1194561 B 1 NC_006038.1 similar to uniprot|Q03497 Saccharomyces cerevisiae YHL007C STE20 Signal transducing kinase of the PAK (p21-activated kinase) family involved in pheromone response and pseudohyphal/invasive growth pathways activated by Cdc42p binds Ste4p at a GBB motif present in noncatalytic domains of PAK kinases; mitogen-activated protein kinase kinase kinase kinase STE20 1194561 2897018 KLLA0_B13607g Kluyveromyces lactis mitogen-activated protein kinase kinase kinase kinase STE20 XP_452137.1 1191592 D 28985 CDS KLLA0_B13629g 2897049 complement(1194646..1196397) B 1 NC_006038.1 similar to uniprot|P35201 Saccharomyces cerevisiae YKL089W MIF2 Kinetochore protein with homology to human CENP-C required for structural integrity of the spindle during anaphase spindle elongation interacts with histones H2A H2B and H4 phosphorylated by Ipl1p; uncharacterized protein 1196397 2897049 KLLA0_B13629g Kluyveromyces lactis uncharacterized protein XP_452138.1 1194646 R 28985 CDS KLLA0_B13651g 2897513 complement(1196688..1198082) B 1 NC_006038.1 similar to uniprot|P36075 Saccharomyces cerevisiae YKL090W CUE2 Protein of unknown function has two CUE domains that bind ubiquitin which may facilitate intramolecular monoubiquitination; uncharacterized protein 1198082 2897513 KLLA0_B13651g Kluyveromyces lactis uncharacterized protein XP_452139.1 1196688 R 28985 CDS KLLA0_B13673g 2897195 complement(1198278..1198961) B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 1198961 2897195 KLLA0_B13673g Kluyveromyces lactis uncharacterized protein XP_452140.1 1198278 R 28985 CDS KLLA0_B13695g 2897196 complement(1199239..1200366) B 1 NC_006038.1 some similarities with uniprot|P38749 Saccharomyces cerevisiae YHL009C YAP3 bZIP transcription factor; uncharacterized protein 1200366 2897196 KLLA0_B13695g Kluyveromyces lactis uncharacterized protein XP_452141.1 1199239 R 28985 CDS KLLA0_B13739g 2897409 complement(1201317..1203608) B 1 NC_006038.1 similar to uniprot|P49956 Saccharomyces cerevisiae YMR078C CTF18 Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion may have overlapping functions with Rad24p in the DNA damage replication checkpoint; uncharacterized protein 1203608 2897409 KLLA0_B13739g Kluyveromyces lactis uncharacterized protein XP_452142.1 1201317 R 28985 CDS KLLA0_B13761g 2897533 1204147..1205226 B 1 NC_006038.1 uniprot|P49379 Kluyveromyces lactis KLLA0B13761g CBF1 Centromere-binding protein 1; uncharacterized protein 1205226 2897533 KLLA0_B13761g Kluyveromyces lactis uncharacterized protein XP_452143.1 1204147 D 28985 CDS KLLA0_B13794g 2897383 1206318..1209128 B 1 NC_006038.1 similar to uniprot|P40355 Saccharomyces cerevisiae YJR061W; uncharacterized protein 1209128 2897383 KLLA0_B13794g Kluyveromyces lactis uncharacterized protein XP_452145.1 1206318 D 28985 CDS KLLA0_B13816g 2897396 complement(1209339..1210580) B 1 NC_006038.1 similar to uniprot|P40354 Saccharomyces cerevisiae YJR062C NTA1 Amidase removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation; amidase 1210580 2897396 KLLA0_B13816g Kluyveromyces lactis amidase XP_452146.1 1209339 R 28985 CDS KLLA0_B13838g 2897429 complement(1211451..1213913) B 1 NC_006038.1 weakly similar to uniprot|P40355 Saccharomyces cerevisiae YJR061W; uncharacterized protein 1213913 2897429 KLLA0_B13838g Kluyveromyces lactis uncharacterized protein XP_452147.1 1211451 R 28985 CDS KLLA0_B13860g 2897537 1215461..1215943 B 1 NC_006038.1 highly similar to uniprot|P32529 Saccharomyces cerevisiae YJR063W RPA12 RNA polymerase I subunit A12.2 contains two zinc binding domains and the N terminal domain is responsible for anchoring to the RNA pol I complex; DNA-directed RNA polymerase I core subunit RPA12 1215943 2897537 KLLA0_B13860g Kluyveromyces lactis DNA-directed RNA polymerase I core subunit RPA12 XP_452148.1 1215461 D 28985 CDS KLLA0_B13882g 2897538 1216203..1217858 B 1 NC_006038.1 highly similar to uniprot|P40413 Saccharomyces cerevisiae YJR064W CCT5 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo; chaperonin-containing T-complex subunit CCT5 1217858 2897538 KLLA0_B13882g Kluyveromyces lactis chaperonin-containing T-complex subunit CCT5 XP_452149.1 1216203 D 28985 CDS KLLA0_B13904g 2897025 complement(1218228..1219598) B 1 NC_006038.1 highly similar to uniprot|P47117 Saccharomyces cerevisiae YJR065C ARP3 Essential component of the Arp2/3 complex which is a highly conserved actin nucleation center required for the motility and integrity of actin patches involved in endocytosis and membrane growth and polarity; actin-related protein 3 1219598 2897025 KLLA0_B13904g Kluyveromyces lactis actin-related protein 3 XP_452150.1 1218228 R 28985 CDS KLLA0_B13926g 2897321 1220237..1221856 B 1 NC_006038.1 similar to uniprot|Q08975 Saccharomyces cerevisiae YPL258C THI21 Hydroxymethylpyrimidine phosphate kinase involved in the last steps in thiamine biosynthesis member of a gene family with THI20 and THI22 functionally redundant with Thi20p; uncharacterized protein 1221856 2897321 KLLA0_B13926g Kluyveromyces lactis uncharacterized protein XP_452151.1 1220237 D 28985 CDS KLLA0_B13948g 2897414 1222276..1229628 B 1 NC_006038.1 highly similar to uniprot|P32600 Saccharomyces cerevisiae YKL203C TOR2 putative protein/phosphatidylinositol kinase involved in signaling activation of translation initiation distribution of the actin cytoskeleton and meiosis phosphatidylinositol kinase homolg; phosphatidylinositol kinase-related protein kinase TOR1 1229628 2897414 KLLA0_B13948g Kluyveromyces lactis phosphatidylinositol kinase-related protein kinase TOR1 XP_452152.1 1222276 D 28985 CDS KLLA0_B13970g 2896975 complement(1229757..1230185) B 1 NC_006038.1 similar to uniprot|P47118 Saccharomyces cerevisiae YJR067C YAE1 Essential protein of unknown function; uncharacterized protein 1230185 2896975 KLLA0_B13970g Kluyveromyces lactis uncharacterized protein XP_452153.1 1229757 R 28985 CDS KLLA0_B13992g 2896976 1230397..1231455 B 1 NC_006038.1 similar to uniprot|P40348 Saccharomyces cerevisiae YJR068W RFC2 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; replication factor C subunit 2 1231455 2896976 KLLA0_B13992g Kluyveromyces lactis replication factor C subunit 2 XP_452154.1 1230397 D 28985 CDS KLLA0_B14014g 2896979 complement(1231530..1233434) B 1 NC_006038.1 weakly similar to uniprot|P36041 Saccharomyces cerevisiae YKL204W EAP1 eIF4E-associated protein; uncharacterized protein 1233434 2896979 KLLA0_B14014g Kluyveromyces lactis uncharacterized protein XP_452155.1 1231530 R 28985 CDS KLLA0_B14036g 2897069 complement(1234021..1237212) B 1 NC_006038.1 similar to uniprot|P33418 Saccharomyces cerevisiae YKL205W LOS1 Nuclear pore protein involved in nuclear export of pre-tRNA; Ran GTPase-binding protein LOS1 1237212 2897069 KLLA0_B14036g Kluyveromyces lactis Ran GTPase-binding protein LOS1 XP_452156.1 1234021 R 28985 CDS KLLA0_B14058g 2897035 complement(1237669..1238253) B 1 NC_006038.1 similar to uniprot|P47119 Saccharomyces cerevisiae YJR069C HAM1 Protein of unknown function that is involved in DNA repair mutant is sensitive to the base analog 6-N-hydroxylaminopurine while gene disruption does not increase the rate of spontaneous mutagenesis; nucleoside triphosphate pyrophosphohydrolase HAM1 1238253 2897035 KLLA0_B14058g Kluyveromyces lactis nucleoside triphosphate pyrophosphohydrolase HAM1 XP_452157.1 1237669 R 28985 CDS KLLA0_B14080g 2897036 complement(1238559..1239527) B 1 NC_006038.1 highly similar to uniprot|P47120 Saccharomyces cerevisiae YJR070C LIA1 Protein that binds to the C-terminal domain of Hyp2p (eIF5A) has four to five HEAT-like repeats; deoxyhypusine monooxygenase 1239527 2897036 KLLA0_B14080g Kluyveromyces lactis deoxyhypusine monooxygenase XP_452158.1 1238559 R 28985 CDS KLLA0_B14102g 2897038 1240181..1240996 B 1 NC_006038.1 similar to uniprot|P36040 Saccharomyces cerevisiae YKL206C; uncharacterized protein 1240996 2897038 KLLA0_B14102g Kluyveromyces lactis uncharacterized protein XP_452159.1 1240181 D 28985 CDS KLLA0_B14124g 2897145 complement(1241070..1242383) B 1 NC_006038.1 highly similar to uniprot|P47122 Saccharomyces cerevisiae YJR072C NPA3 Cytoplasmic protein required for cell viability identified by association with pre-ribosomal particles; GTPase NPA3 1242383 2897145 KLLA0_B14124g Kluyveromyces lactis GTPase NPA3 XP_452160.1 1241070 R 28985 CDS KLLA0_B14146g 2897152 complement(1242562..1243374) B 1 NC_006038.1 similar to uniprot|P36039 Saccharomyces cerevisiae YKL207W; uncharacterized protein 1243374 2897152 KLLA0_B14146g Kluyveromyces lactis uncharacterized protein XP_452161.1 1242562 R 28985 CDS KLLA0_B14168g 2897154 complement(1243715..1245538) B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 1245538 2897154 KLLA0_B14168g Kluyveromyces lactis uncharacterized protein XP_452162.1 1243715 R 28985 CDS KLLA0_B14190g 2897155 complement(1245746..1246495) B 1 NC_006038.1 no similarity; uncharacterized protein 1246495 2897155 KLLA0_B14190g Kluyveromyces lactis uncharacterized protein XP_452163.1 1245746 R 28985 CDS KLLA0_B14234g 2897198 complement(1247175..1247831) B 1 NC_006038.1 similar to uniprot|P05375 Saccharomyces cerevisiae YJR073C OPI3 Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase) catalyzes the last two steps in phosphatidylcholine biosynthesis; bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase 1247831 2897198 KLLA0_B14234g Kluyveromyces lactis bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase XP_452164.1 1247175 R 28985 CDS KLLA0_B14256g 2897199 1248654..1252469 B 1 NC_006038.1 similar to uniprot|P12866 Saccharomyces cerevisiae YKL209C STE6 ATP-binding cassette (ABC) transporter required for the export of a-factor catalyzes ATP hydrolysis coupled to a-factor transport contains 12 transmembrane domains and two ATP binding domains expressed only in MATa cells; ATP-binding cassette a-factor transporter STE6 1252469 2897199 KLLA0_B14256g Kluyveromyces lactis ATP-binding cassette a-factor transporter STE6 XP_452165.1 1248654 D 28985 CDS KLLA0_B14278g 2897356 complement(1252596..1255655) B 1 NC_006038.1 highly similar to uniprot|P22515 Saccharomyces cerevisiae YKL210W UBA1 Ubiquitin activating enzyme involved in ubiquitin-mediated protein degradation and essential for viability; E1 ubiquitin-activating protein UBA1 1255655 2897356 KLLA0_B14278g Kluyveromyces lactis E1 ubiquitin-activating protein UBA1 XP_452166.1 1252596 R 28985 CDS KLLA0_B14300g 2897369 1256190..1256783 B 1 NC_006038.1 similar to uniprot|P47123 Saccharomyces cerevisiae YJR074W MOG1 Conserved nuclear protein that interacts with GTP-Gsp1p which is a Ran homolog of the Ras GTPase family and stimulates nucleotide release involved in nuclear protein import nucleotide release is inhibited by Yrb1p; Ran GTPase-binding protein MOG1 1256783 2897369 KLLA0_B14300g Kluyveromyces lactis Ran GTPase-binding protein MOG1 XP_452167.1 1256190 D 28985 CDS KLLA0_B14322g 2897339 1256993..1258189 B 1 NC_006038.1 similar to uniprot|P47124 Saccharomyces cerevisiae YJR075W HOC1 Alpha-1 6-mannosyltransferase involved in cell wall mannan biosynthesis subunit of a Golgi-localized complex that also contains Anp1p Mnn9p Mnn11p and Mnn10p identified as a suppressor of a cell lysis sensitive pkc1-371 allele; alpha-1,6-mannosyltransferase 1258189 2897339 KLLA0_B14322g Kluyveromyces lactis alpha-1,6-mannosyltransferase XP_452168.1 1256993 D 28985 CDS KLLA0_B14344g 2897340 complement(1258807..1260069) B 1 NC_006038.1 similar to uniprot|P32458 Saccharomyces cerevisiae YJR076C CDC11 Component of the septin ring of the mother-bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM; septin CDC11 1260069 2897340 KLLA0_B14344g Kluyveromyces lactis septin CDC11 XP_452169.1 1258807 R 28985 CDS KLLA0_B14366g 2897007 1260726..1262198 B 1 NC_006038.1 highly similar to uniprot|P00937 Saccharomyces cerevisiae YKL211C TRP3 anthranilate synthase Component II and indole-3-phosphate (multifunctional enzyme); bifunctional anthranilate synthase/indole-3-glycerol-phosphate synthase 1262198 2897007 KLLA0_B14366g Kluyveromyces lactis bifunctional anthranilate synthase/indole-3-glycerol-phosphate synthase XP_452170.1 1260726 D 28985 CDS KLLA0_B14388g 2896966 complement(1262423..1264300) B 1 NC_006038.1 similar to uniprot|P32368 Saccharomyces cerevisiae YKL212W SAC1 Lipid phosphoinositide phosphatase of the ER and Golgi involved in protein trafficking and secretion; phosphatidylinositol-3-phosphatase SAC1 1264300 2896966 KLLA0_B14388g Kluyveromyces lactis phosphatidylinositol-3-phosphatase SAC1 XP_452171.1 1262423 R 28985 CDS KLLA0_B14410g 2896889 1264616..1266736 B 1 NC_006038.1 similar to uniprot|P36037 Saccharomyces cerevisiae YKL213C DOA1 WD repeat protein required for ubiquitin-mediated protein degradation forms complex with Cdc48p plays a role in controlling cellular ubiquitin concentration also promotes efficient NHEJ in postdiauxic/stationary phase; uncharacterized protein 1266736 2896889 KLLA0_B14410g Kluyveromyces lactis uncharacterized protein XP_452172.1 1264616 D 28985 CDS KLLA0_B14432g 2897022 join(1267069..1267110,1267269..1267877) B 1 NC_006038.1 weakly similar to uniprot|P36036 Saccharomyces cerevisiae YKL214C YRA2 Member of the REF (RNA and export factor binding proteins) family when overexpressed can substitute for the function of Yra1p in export of poly(A) mRNA from the nucleus; uncharacterized protein 1267877 2897022 KLLA0_B14432g Kluyveromyces lactis uncharacterized protein XP_452173.2 1267069 D 28985 CDS KLLA0_B14454g 2897023 complement(1268709..1269626) B 1 NC_006038.1 highly similar to uniprot|P23641 Saccharomyces cerevisiae YJR077C MIR1 Mitochondrial phosphate carrier imports inorganic phosphate into mitochondria functionally redundant with Pic2p but more abundant than Pic2 under normal conditions; uncharacterized protein 1269626 2897023 KLLA0_B14454g Kluyveromyces lactis uncharacterized protein XP_452174.1 1268709 R 28985 CDS KLLA0_B14476g 2896907 1271319..1272506 B 1 NC_006038.1 similar to uniprot|P39676 Saccharomyces cerevisiae YGR234W YHB1 Flavohemoglobin may play a role in the oxidative stress response; flavohemoglobin 1272506 2896907 KLLA0_B14476g Kluyveromyces lactis flavohemoglobin XP_452175.1 1271319 D 28985 CDS KLLA0_B14498g 2897507 1275022..1277322 B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 1277322 2897507 KLLA0_B14498g Kluyveromyces lactis uncharacterized protein XP_452176.1 1275022 D 28985 CDS KLLA0_B14531g 2897452 1278225..1278557 B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 1278557 2897452 KLLA0_B14531g Kluyveromyces lactis uncharacterized protein XP_452178.1 1278225 D 28985 CDS KLLA0_B14553g 2897450 complement(1278622..1279308) B 1 NC_006038.1 uniprot|Q9HG12 Kluyveromyces lactis KLLA0B14553g HMRA1 Mating-type protein A1; uncharacterized protein 1279308 2897450 KLLA0_B14553g Kluyveromyces lactis uncharacterized protein XP_452179.1 1278622 R 28985 CDS KLLA0_B14575g 2897386 1280163..1280936 B 1 NC_006038.1 uniprot|Q9HG13 Kluyveromyces lactis KLLA0B14575g HMRA2 Mating-type protein A2; uncharacterized protein 1280936 2897386 KLLA0_B14575g Kluyveromyces lactis uncharacterized protein XP_452180.1 1280163 D 28985 CDS KLLA0_B14597g 2897323 complement(1281354..1281677) B 1 NC_006038.1 no similarity; uncharacterized protein 1281677 2897323 KLLA0_B14597g Kluyveromyces lactis uncharacterized protein XP_452181.1 1281354 R 28985 CDS KLLA0_B14619g 2897380 complement(1284933..1286528) B 1 NC_006038.1 some similarities with uniprot|P38866 Saccharomyces cerevisiae YHR176W FMO1 Flavin-containing monooxygenase localized to the cytoplasmic face of the ER membrane catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide- bonded proteins; uncharacterized protein 1286528 2897380 KLLA0_B14619g Kluyveromyces lactis uncharacterized protein XP_452182.1 1284933 R 28985 CDS KLLA0_B14685g 2897543 complement(1289025..1290740) B 1 NC_006038.1 weakly similar to uniprot|P15380 Saccharomyces cerevisiae YOR348C PUT4 proline-specific permease (also capable of transporting alanine and glycine) putative proline-specific permease; uncharacterized protein 1290740 2897543 KLLA0_B14685g Kluyveromyces lactis uncharacterized protein XP_452185.1 1289025 R 28985 CDS KLLA0_B14707g 2897299 complement(1291951..1292883) B 1 NC_006038.1 similar to uniprot|Q12458 Saccharomyces cerevisiae YDR368W YPR1 2-methylbutyraldehyde reductase may be involved in isoleucine catabolism; uncharacterized protein 1292883 2897299 KLLA0_B14707g Kluyveromyces lactis uncharacterized protein XP_452186.1 1291951 R 28985 CDS KLLA0_B14729g 2897300 complement(1293568..1294983) B 1 NC_006038.1 weakly similar to uniprot|P18544 Saccharomyces cerevisiae YOL140W ARG8 Acetylornithine aminotransferase catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine; uncharacterized protein 1294983 2897300 KLLA0_B14729g Kluyveromyces lactis uncharacterized protein XP_452187.1 1293568 R 28985 CDS KLLA0_B14751g 2897296 complement(1296263..1298125) B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 1298125 2897296 KLLA0_B14751g Kluyveromyces lactis uncharacterized protein XP_452188.1 1296263 R 28985 CDS KLLA0_B14773g 2897281 complement(1298671..1299051) B 1 NC_006038.1 no similarity; uncharacterized protein 1299051 2897281 KLLA0_B14773g Kluyveromyces lactis uncharacterized protein XP_452189.1 1298671 R 28985 CDS KLLA0_B14795g 2897257 1299429..1301099 B 1 NC_006038.1 similar to uniprot|P00175 Saccharomyces cerevisiae YML054C CYB2 Cytochrome b2 (L-lactate cytochrome-c oxidoreductase) component of the mitochondrial intermembrane space required for lactate utilization expression is repressed by glucose and anaerobic conditions; uncharacterized protein 1301099 2897257 KLLA0_B14795g Kluyveromyces lactis uncharacterized protein XP_452190.1 1299429 D 28985 CDS KLLA0_B14817g 2897249 1301705..1302100 B 1 NC_006038.1 weakly similar to uniprot|P40185 Saccharomyces cerevisiae YIL051C MMF1 Mitochondrial protein involved in maintenance of the mitochondrial genome and weakly similar to YER057C uniprot|P40037 Saccharomyces cerevisiae YER057C HMF1 Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro; uncharacterized protein 1302100 2897249 KLLA0_B14817g Kluyveromyces lactis uncharacterized protein XP_452191.1 1301705 D 28985 CDS KLLA0_B14839g 2897102 complement(1304089..1305354) B 1 NC_006038.1 conserved hypothetical protein; uncharacterized protein 1305354 2897102 KLLA0_B14839g Kluyveromyces lactis uncharacterized protein XP_452192.1 1304089 R 28985 CDS KLLA0_B14861g 2897085 complement(1305927..1307690) B 1 NC_006038.1 uniprot|P07921 Kluyveromyces lactis KLLA0B14861g LAC12 Lactose permease; uncharacterized protein 1307690 2897085 KLLA0_B14861g Kluyveromyces lactis uncharacterized protein XP_452193.1 1305927 R 28985 CDS KLLA0_B14883g 2897170 1310501..1313578 B 1 NC_006038.1 uniprot|P00723 Kluyveromyces lactis KLLA0B14883g LAC4 Beta-galactosidase; uncharacterized protein 1313578 2897170 KLLA0_B14883g Kluyveromyces lactis uncharacterized protein XP_452194.1 1310501 D 28985 CDS KLLA0_B14916g 2897228 1315518..1317170 B 1 NC_006038.1 some similarities with uniprot|P38894 Saccharomyces cerevisiae YHR211W FLO5 Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p; uncharacterized protein 1317170 2897228 KLLA0_B14916g Kluyveromyces lactis uncharacterized protein XP_452196.1 1315518 D 28985 CDS KLLA0_B14927g 2897183 1317448..1318428 B 1 NC_006038.1 no similarity; uncharacterized protein 1318428 2897183 KLLA0_B14927g Kluyveromyces lactis uncharacterized protein XP_452197.1 1317448 D 28985 CDS KLLA0_B14949g 2897173 complement(1319529..1320071) B 1 NC_006038.1 no similarity; uncharacterized protein 1320071 2897173 KLLA0_B14949g Kluyveromyces lactis uncharacterized protein XP_452198.1 1319529 R 28985 CDS KLLA0_C00110g 2892341 2600..3646 C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 3646 2892341 KLLA0_C00110g Kluyveromyces lactis uncharacterized protein XP_452199.2 2600 D 28985 CDS KLLA0_C00132g 2892652 4440..5963 C 1 NC_006039.1 similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport; uncharacterized protein 5963 2892652 KLLA0_C00132g Kluyveromyces lactis uncharacterized protein XP_452200.1 4440 D 28985 CDS KLLA0_C00154g 2892086 complement(6401..6868) C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 6868 2892086 KLLA0_C00154g Kluyveromyces lactis uncharacterized protein XP_452201.1 6401 R 28985 CDS KLLA0_C00176g 2891884 7953..8393 C 1 NC_006039.1 no similarity; uncharacterized protein 8393 2891884 KLLA0_C00176g Kluyveromyces lactis uncharacterized protein XP_452202.1 7953 D 28985 CDS KLLA0_C00190g 9487496 10530..10829 C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 10829 9487496 KLLA0_C00190g Kluyveromyces lactis uncharacterized protein XP_002999357.1 10530 D 28985 CDS KLLA0_C00198g 2892319 12387..12674 C 1 NC_006039.1 no similarity; uncharacterized protein 12674 2892319 KLLA0_C00198g Kluyveromyces lactis uncharacterized protein XP_452203.2 12387 D 28985 CDS KLLA0_C00220g 2892172 13632..15506 C 1 NC_006039.1 similar to uniprot|P38724 Saccharomyces cerevisiae YHL047C ARN2 Transporter member of the ARN family of transporters that specifically recognize siderophore-iron chelates responsible for uptake of iron bound to the siderophore triacetylfusarinine C; glutathione exchanger 15506 2892172 KLLA0_C00220g Kluyveromyces lactis glutathione exchanger XP_452204.1 13632 D 28985 CDS KLLA0_C00242g 2892321 15961..16272 C 1 NC_006039.1 no similarity; uncharacterized protein 16272 2892321 KLLA0_C00242g Kluyveromyces lactis uncharacterized protein XP_452205.1 15961 D 28985 CDS KLLA0_C00264g 2891988 complement(17326..18102) C 1 NC_006039.1 similar to uniprot|Q12512 Saccharomyces cerevisiae YOL154W ZPS1 Putative GPI-anchored protein transcription is induced under low-zinc conditions as mediated by the Zap1p transcription factor and at alkaline pH; uncharacterized protein 18102 2891988 KLLA0_C00264g Kluyveromyces lactis uncharacterized protein XP_452206.1 17326 R 28985 CDS KLLA0_C00286g 2892313 19668..21206 C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 21206 2892313 KLLA0_C00286g Kluyveromyces lactis uncharacterized protein XP_452207.1 19668 D 28985 CDS KLLA0_C00330g 2892351 23718..24050 C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 24050 2892351 KLLA0_C00330g Kluyveromyces lactis uncharacterized protein XP_452209.2 23718 D 28985 CDS KLLA0_C00352g 2892594 complement(24124..24909) C 1 NC_006039.1 uniprot|Q08398 Kluyveromyces lactis HMLAPLHA1 Mating- type protein ALPHA1; transcriptional co-activator mating type protein alpha 24909 2892594 KLLA0_C00352g Kluyveromyces lactis transcriptional co-activator mating type protein alpha XP_452210.1 24124 R 28985 CDS KLLA0_C00374g 2892167 25132..25803 C 1 NC_006039.1 uniprot|Q9HDS5 Kluyveromyces lactis HMLALPHA2 Mating- type protein ALPHA2; homeodomain mating type protein alpha2 25803 2892167 KLLA0_C00374g Kluyveromyces lactis homeodomain mating type protein alpha2 XP_452211.1 25132 D 28985 CDS KLLA0_C00396g 2892032 complement(26146..28839) C 1 NC_006039.1 uniprot|Q9HDS6 Kluyveromyces lactis HMLALPHA3 Mating- type protein ALPHA3; uncharacterized protein 28839 2892032 KLLA0_C00396g Kluyveromyces lactis uncharacterized protein XP_452212.1 26146 R 28985 CDS KLLA0_C00440g 2892345 complement(32008..33141) C 1 NC_006039.1 similar to uniprot|P25379 Saccharomyces cerevisiae YCL064C CHA1 catabolism of hydroxy amino acids catabolic serine (threonine) dehydratase; L-serine/L-threonine ammonia-lyase CHA1 33141 2892345 KLLA0_C00440g Kluyveromyces lactis L-serine/L-threonine ammonia-lyase CHA1 XP_452213.1 32008 R 28985 CDS KLLA0_C00462g 2892347 33948..35330 C 1 NC_006039.1 weakly similar to uniprot|P25591 Saccharomyces cerevisiae YCL063W VAC17 vacuole inheritance; uncharacterized protein 35330 2892347 KLLA0_C00462g Kluyveromyces lactis uncharacterized protein XP_452214.1 33948 D 28985 CDS KLLA0_C00484g 2892334 complement(35397..38174) C 1 NC_006039.1 weakly similar to uniprot|P25588 Saccharomyces cerevisiae YCL061C MRC1 S-phase checkpoint protein found at replication forks required for DNA replication also required for Rad53p activation during DNA replication stress where it forms a replication-pausing complex with Tof1p and is phosphorylated by Mec1p protein involved in replication checkpoint; chromatin-modulating protein MRC1 38174 2892334 KLLA0_C00484g Kluyveromyces lactis chromatin-modulating protein MRC1 XP_452215.1 35397 R 28985 CDS KLLA0_C00506g 2892323 complement(38584..39576) C 1 NC_006039.1 highly similar to uniprot|P25586 Saccharomyces cerevisiae YCL059C KRR1 Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit; ribosome biosynthesis protein KRR1 39576 2892323 KLLA0_C00506g Kluyveromyces lactis ribosome biosynthesis protein KRR1 XP_452216.1 38584 R 28985 CDS KLLA0_C00528g 2892400 40060..40410 C 1 NC_006039.1 no similarity; uncharacterized protein 40410 2892400 KLLA0_C00528g Kluyveromyces lactis uncharacterized protein XP_452217.1 40060 D 28985 CDS KLLA0_C00550g 2892394 complement(40901..41149) C 1 NC_006039.1 similar to uniprot|Q96VH5 Saccharomyces cerevisiae YCL057C-A; uncharacterized protein 41149 2892394 KLLA0_C00550g Kluyveromyces lactis uncharacterized protein XP_452218.1 40901 R 28985 CDS KLLA0_C00572g 2892384 42069..44207 C 1 NC_006039.1 similar to uniprot|P25375 Saccharomyces cerevisiae YCL057W PRD1 Zinc metalloendopeptidase found in the cytoplasm and intermembrane space of mitochondria; metalloendopeptidase 44207 2892384 KLLA0_C00572g Kluyveromyces lactis metalloendopeptidase XP_452219.1 42069 D 28985 CDS KLLA0_C00594g 2892392 complement(44220..44804) C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 44804 2892392 KLLA0_C00594g Kluyveromyces lactis uncharacterized protein XP_452220.1 44220 R 28985 CDS KLLA0_C00616g 2892317 45284..45739 C 1 NC_006039.1 no similarity; uncharacterized protein 45739 2892317 KLLA0_C00616g Kluyveromyces lactis uncharacterized protein XP_452221.1 45284 D 28985 CDS KLLA0_C00649g 2892079 46562..47566 C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 47566 2892079 KLLA0_C00649g Kluyveromyces lactis uncharacterized protein XP_452223.1 46562 D 28985 CDS KLLA0_C00671g 2892179 complement(47903..49039) C 1 NC_006039.1 no similarity; uncharacterized protein 49039 2892179 KLLA0_C00671g Kluyveromyces lactis uncharacterized protein XP_452224.1 47903 R 28985 CDS KLLA0_C00693g 2892371 49512..50483 C 1 NC_006039.1 similar to uniprot|P25583 Saccharomyces cerevisiae YCL055W; uncharacterized protein 50483 2892371 KLLA0_C00693g Kluyveromyces lactis uncharacterized protein XP_452225.1 49512 D 28985 CDS KLLA0_C00715g 2892470 complement(50670..52187) C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 52187 2892470 KLLA0_C00715g Kluyveromyces lactis uncharacterized protein XP_452226.1 50670 R 28985 CDS KLLA0_C00737g 2892065 53188..55689 C 1 NC_006039.1 similar to uniprot|P25582 Saccharomyces cerevisiae YCL054W SPB1 AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation methylates G2922 in the putative tRNA docking site of the large subunit rRNA and in the absence of snR52 U2921 suppressor of PAB1 mutants; 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase 55689 2892065 KLLA0_C00737g Kluyveromyces lactis 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase XP_452227.1 53188 D 28985 CDS KLLA0_C00759g 2892115 complement(55778..57022) C 1 NC_006039.1 similar to uniprot|P25580 Saccharomyces cerevisiae YCL052C PBN1 Essential component of glycosylphosphatidylinositol-mannosyltransferase I required for the autocatalytic post-translational processing of the protease B precursor Prb1p localizes to ER in lumenal orientation homolog of mammalian PIG-X; uncharacterized protein 57022 2892115 KLLA0_C00759g Kluyveromyces lactis uncharacterized protein XP_452228.1 55778 R 28985 CDS KLLA0_C00803g 2892364 59258..60580 C 1 NC_006039.1 some similarities with uniprot|P25579 Saccharomyces cerevisiae YCL051W LRE1 Protein involved in control of cell wall structure and stress response inhibits Cbk1p protein kinase activity overproduction confers resistance to cell-wall degrading enzymes; uncharacterized protein 60580 2892364 KLLA0_C00803g Kluyveromyces lactis uncharacterized protein XP_452230.1 59258 D 28985 CDS KLLA0_C00825g 2892603 complement(61186..61569) C 1 NC_006039.1 highly similar to uniprot|P00128 Saccharomyces cerevisiae YDR529C; ubiquinol--cytochrome-c reductase subunit 7 61569 2892603 KLLA0_C00825g Kluyveromyces lactis ubiquinol--cytochrome-c reductase subunit 7 XP_452231.1 61186 R 28985 CDS KLLA0_C00847g 2892615 complement(62156..63151) C 1 NC_006039.1 similar to uniprot|P22108 Saccharomyces cerevisiae YDR530c APA2 Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II; uncharacterized protein 63151 2892615 KLLA0_C00847g Kluyveromyces lactis uncharacterized protein XP_452232.1 62156 R 28985 CDS KLLA0_C00869g 2892157 64120..65241 C 1 NC_006039.1 similar to uniprot|Q04430 Saccharomyces cerevisiae YDR531W Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase EC 2.7.1.33) catalyzes the first committed step in the universal biosynthetic pathway leading to CoA.; pantothenate kinase 65241 2892157 KLLA0_C00869g Kluyveromyces lactis pantothenate kinase XP_452233.1 64120 D 28985 CDS KLLA0_C00891g 2892376 complement(65443..66498) C 1 NC_006039.1 weakly similar to uniprot|Q04431 Saccharomyces cerevisiae YDR532C KRE28; uncharacterized protein 66498 2892376 KLLA0_C00891g Kluyveromyces lactis uncharacterized protein XP_452234.1 65443 R 28985 CDS KLLA0_C00913g 2892136 complement(67336..68760) C 1 NC_006039.1 similar to uniprot|Q04418 Saccharomyces cerevisiae YDR527W; uncharacterized protein 68760 2892136 KLLA0_C00913g Kluyveromyces lactis uncharacterized protein XP_452235.1 67336 R 28985 CDS KLLA0_C00935g 2892111 complement(69125..69352) C 1 NC_006039.1 similar to uniprot|P56508 Saccharomyces cerevisiae YDR525W-A; uncharacterized protein 69352 2892111 KLLA0_C00935g Kluyveromyces lactis uncharacterized protein XP_452236.1 69125 R 28985 CDS KLLA0_C00957g 2892134 71640..71855 C 1 NC_006039.1 no similarity; uncharacterized protein 71855 2892134 KLLA0_C00957g Kluyveromyces lactis uncharacterized protein XP_452237.1 71640 D 28985 CDS KLLA0_C00979g 2892365 73295..74746 C 1 NC_006039.1 similar to uniprot|P08458 Saccharomyces cerevisiae YDR523C SPS1 dispensable for mitosis involved in middle/late stage of meiosis required for spore wall formation serine/threonine kinase homologous to Ste20p expressed in middle/late meiosis; uncharacterized protein 74746 2892365 KLLA0_C00979g Kluyveromyces lactis uncharacterized protein XP_452238.1 73295 D 28985 CDS KLLA0_C01001g 2892566 75286..76575 C 1 NC_006039.1 similar to uniprot|P25380 Saccharomyces cerevisiae YCL048W SPS22 Protein of unknown function redundant with Sps2p for the organization of the beta-glucan layer of the spore wall; uncharacterized protein 76575 2892566 KLLA0_C01001g Kluyveromyces lactis uncharacterized protein XP_452239.1 75286 D 28985 CDS KLLA0_C01023g 2892390 76863..78773 C 1 NC_006039.1 similar to uniprot|Q04411 Saccharomyces cerevisiae YDR520C Hypothetical ORF; uncharacterized protein 78773 2892390 KLLA0_C01023g Kluyveromyces lactis uncharacterized protein XP_452240.1 76863 D 28985 CDS KLLA0_C01045g 2892052 complement(78938..79360) C 1 NC_006039.1 similar to uniprot|P32472 Saccharomyces cerevisiae YDR519W FPR2 Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase) binds to the drugs FK506 and rapamycin expression pattern suggests possible involvement in ER protein trafficking; peptidylprolyl isomerase family protein FPR2 79360 2892052 KLLA0_C01045g Kluyveromyces lactis peptidylprolyl isomerase family protein FPR2 XP_452241.1 78938 R 28985 CDS KLLA0_C01067g 2892657 complement(79651..81825) C 1 NC_006039.1 similar to uniprot|P25574 Saccharomyces cerevisiae YCL045C; uncharacterized protein 81825 2892657 KLLA0_C01067g Kluyveromyces lactis uncharacterized protein XP_452242.1 79651 R 28985 CDS KLLA0_C01089g 2892372 complement(82159..83307) C 1 NC_006039.1 similar to uniprot|P25573 Saccharomyces cerevisiae YCL044C; uncharacterized protein 83307 2892372 KLLA0_C01089g Kluyveromyces lactis uncharacterized protein XP_452243.1 82159 R 28985 CDS KLLA0_C01111g 2892548 complement(83710..85293) C 1 NC_006039.1 similar to uniprot|P17967 Saccharomyces cerevisiae YCL043C PDI and similar to uniprot|P32474 Saccharomyces cerevisiae YDR518W EUG1 Protein disulfide isomerases; protein disulfide isomerase PDI1 85293 2892548 KLLA0_C01111g Kluyveromyces lactis protein disulfide isomerase PDI1 XP_452244.1 83710 R 28985 CDS KLLA0_C01133g 2892402 complement(85863..87029) C 1 NC_006039.1 similar to uniprot|Q04410 Saccharomyces cerevisiae YDR517W GRH1 Golgi localized protein component of the spindle assembly checkpoint homolog of human GRASP65 which functions in postmitotic reassembly of Golgi stacks; uncharacterized protein 87029 2892402 KLLA0_C01133g Kluyveromyces lactis uncharacterized protein XP_452245.1 85863 R 28985 CDS KLLA0_C01155g 2892353 88084..89529 C 1 NC_006039.1 similar to uniprot|P17709 Saccharomyces cerevisiae YCL040W GLK1 Glucokinase catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism one of three glucose phosphorylating enzymes expression regulated by non-fermentable carbon sources; uncharacterized protein 89529 2892353 KLLA0_C01155g Kluyveromyces lactis uncharacterized protein XP_452246.1 88084 D 28985 CDS KLLA0_C01177g 2892380 89978..92131 C 1 NC_006039.1 similar to uniprot|P25569 Saccharomyces cerevisiae YCL039W; glucose-induced degradation complex subunit GID7 92131 2892380 KLLA0_C01177g Kluyveromyces lactis glucose-induced degradation complex subunit GID7 XP_452247.1 89978 D 28985 CDS KLLA0_C01188g 2892359 complement(92124..93602) C 1 NC_006039.1 similar to uniprot|P25568 Saccharomyces cerevisiae YCL038C ATG22 Protein required for the breakdown of autophagic vesicles in the vacuole during autophagy putative integral membrane protein that localizes to vacuolar membranes and punctate structures attached to the vacuole; uncharacterized protein 93602 2892359 KLLA0_C01188g Kluyveromyces lactis uncharacterized protein XP_452248.1 92124 R 28985 CDS KLLA0_C01210g 2892368 complement(93918..95408) C 1 NC_006039.1 weakly similar to uniprot|P25567 Saccharomyces cerevisiae YCL037C SRO9 Associates with translating ribosomes may function in the cytoplasm to modulate mRNA translation may be involved in organization of actin filaments RNA binding protein with La motif; uncharacterized protein 95408 2892368 KLLA0_C01210g Kluyveromyces lactis uncharacterized protein XP_452249.1 93918 R 28985 CDS KLLA0_C01232g 2892311 96317..97417 C 1 NC_006039.1 some similarities with uniprot|Q04408 Saccharomyces cerevisiae YDR514C Hypothetical ORF; uncharacterized protein 97417 2892311 KLLA0_C01232g Kluyveromyces lactis uncharacterized protein XP_452250.1 96317 D 28985 CDS KLLA0_C01254g 2892426 97735..98940 C 1 NC_006039.1 some similarities with uniprot|Q04408 Saccharomyces cerevisiae YDR514C Hypothetical ORF; uncharacterized protein 98940 2892426 KLLA0_C01254g Kluyveromyces lactis uncharacterized protein XP_452251.1 97735 D 28985 CDS KLLA0_C01276g 2892481 100213..101334 C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 101334 2892481 KLLA0_C01276g Kluyveromyces lactis uncharacterized protein XP_452252.1 100213 D 28985 CDS KLLA0_C01298g 2892377 complement(101676..101999) C 1 NC_006039.1 weakly similar to uniprot|P25567 Saccharomyces cerevisiae YCL037C SRO9 Associates with translating ribosomes and weakly similar to uniprot|Q12034 Saccharomyces cerevisiae YDR515W SLF1 RNA binding protein that associates with polysomes; dithiol glutaredoxin GRX1 101999 2892377 KLLA0_C01298g Kluyveromyces lactis dithiol glutaredoxin GRX1 XP_452253.1 101676 R 28985 CDS KLLA0_C01320g 2892425 103218..104225 C 1 NC_006039.1 similar to uniprot|P25369 Saccharomyces cerevisiae YCL034W LSB5 Protein of unknown function binds Las17p which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; uncharacterized protein 104225 2892425 KLLA0_C01320g Kluyveromyces lactis uncharacterized protein XP_452254.1 103218 D 28985 CDS KLLA0_C01342g 2892540 complement(104355..104954) C 1 NC_006039.1 similar to uniprot|P25566 Saccharomyces cerevisiae YCL033C Hypothetical ORF; peptide-methionine (R)-S-oxide reductase 104954 2892540 KLLA0_C01342g Kluyveromyces lactis peptide-methionine (R)-S-oxide reductase XP_452255.1 104355 R 28985 CDS KLLA0_C01364g 2892307 105157..105417 C 1 NC_006039.1 some similarities with uniprot|Q04406 Saccharomyces cerevisiae YDR512C; uncharacterized protein 105417 2892307 KLLA0_C01364g Kluyveromyces lactis uncharacterized protein XP_452256.1 105157 D 28985 CDS KLLA0_C01386g 2892108 105812..106699 C 1 NC_006039.1 similar to uniprot|P25344 Saccharomyces cerevisiae YCL032W STE50 Protein involved in mating response invasive/filamentous growth and osmotolerance acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction; uncharacterized protein 106699 2892108 KLLA0_C01386g Kluyveromyces lactis uncharacterized protein XP_452257.1 105812 D 28985 CDS KLLA0_C01408g 2892437 complement(106905..107885) C 1 NC_006039.1 similar to uniprot|P25368 Saccharomyces cerevisiae YCL031C RRP7 involved in rRNA processing; uncharacterized protein 107885 2892437 KLLA0_C01408g Kluyveromyces lactis uncharacterized protein XP_452258.1 106905 R 28985 CDS KLLA0_C01430g 2892688 complement(108092..108481) C 1 NC_006039.1 some similarities with uniprot|Q02562 Saccharomyces cerevisiae YDR511W ACN9 Protein of the mitochondrial intermembrane space required for acetate utilization and gluconeogenesis has orthologs in higher eukaryotes; uncharacterized protein 108481 2892688 KLLA0_C01430g Kluyveromyces lactis uncharacterized protein XP_452259.1 108092 R 28985 CDS KLLA0_C01452g 2892606 complement(108796..111183) C 1 NC_006039.1 highly similar to uniprot|P00815 Saccharomyces cerevisiae YCL030C; trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase 111183 2892606 KLLA0_C01452g Kluyveromyces lactis trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase XP_452260.1 108796 R 28985 CDS KLLA0_C01474g 2892096 complement(111545..112765) C 1 NC_006039.1 similar to uniprot|P11709 Saccharomyces cerevisiae YCL029C BIK1 Microtubule-associated protein component of the interface between microtubules and kinetochore involved in sister chromatid separation essential in polyploid cells but not in haploid or diploid cells ortholog of mammalian CLIP-170; uncharacterized protein 112765 2892096 KLLA0_C01474g Kluyveromyces lactis uncharacterized protein XP_452261.1 111545 R 28985 CDS KLLA0_C01496g 2892436 complement(113533..114903) C 1 NC_006039.1 some similarities with uniprot|P47032 Saccharomyces cerevisiae YJL079C PRY1 Protein of unknown function, has similarity to Pry2p and Pry3p and to the plant PR-1 class of pathogen related proteins; uncharacterized protein 114903 2892436 KLLA0_C01496g Kluyveromyces lactis uncharacterized protein XP_452262.1 113533 R 28985 CDS KLLA0_C01518g 2891970 116685..117131 C 1 NC_006039.1 no similarity; uncharacterized protein 117131 2891970 KLLA0_C01518g Kluyveromyces lactis uncharacterized protein XP_452263.1 116685 D 28985 CDS KLLA0_C01540g 2892541 118950..120482 C 1 NC_006039.1 uniprot|Q8NJT3 Kluyveromyces lactis Fus1 protein (Similarity).; uncharacterized protein 120482 2892541 KLLA0_C01540g Kluyveromyces lactis uncharacterized protein XP_452264.1 118950 D 28985 CDS KLLA0_C01562g 2892396 complement(120691..121281) C 1 NC_006039.1 highly similar to uniprot|Q8NIM8 Saccharomyces cerevisiae YCL026C- B Hypothetical ORF and similar to YCL026c-A; uncharacterized protein 121281 2892396 KLLA0_C01562g Kluyveromyces lactis uncharacterized protein XP_452265.1 120691 R 28985 CDS KLLA0_C01584g 2892438 122103..123098 C 1 NC_006039.1 no similarity; uncharacterized protein 123098 2892438 KLLA0_C01584g Kluyveromyces lactis uncharacterized protein XP_452266.1 122103 D 28985 CDS KLLA0_C01606g 2892234 complement(123485..125347) C 1 NC_006039.1 similar to uniprot|P48813 Saccharomyces cerevisiae YDR508C GNP1 High-affinity glutamine permease also transports Leu Ser Thr Cys Met and Asn expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; amino acid transporter AGP1 125347 2892234 KLLA0_C01606g Kluyveromyces lactis amino acid transporter AGP1 XP_452267.1 123485 R 28985 CDS KLLA0_C01628g 2892007 126942..127223 C 1 NC_006039.1 highly similar to uniprot|Q12306 Saccharomyces cerevisiae YDR510W; SUMO family protein SMT3 127223 2892007 KLLA0_C01628g Kluyveromyces lactis SUMO family protein SMT3 XP_452268.1 126942 D 28985 CDS KLLA0_C01650g 2892358 128119..131457 C 1 NC_006039.1 similar to uniprot|Q12263 Saccharomyces cerevisiae YDR507C; uncharacterized protein 131457 2892358 KLLA0_C01650g Kluyveromyces lactis uncharacterized protein XP_452269.1 128119 D 28985 CDS KLLA0_C01672g 2891935 complement(131543..132772) C 1 NC_006039.1 weakly similar to uniprot|P41816 Saccharomyces cerevisiae YPL171C OYE3 Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); uncharacterized protein 132772 2891935 KLLA0_C01672g Kluyveromyces lactis uncharacterized protein XP_452270.1 131543 R 28985 CDS KLLA0_C01694g 2892187 133089..134927 C 1 NC_006039.1 similar to uniprot|Q04399 Saccharomyces cerevisiae YDR506C Hypothetical ORF; uncharacterized protein 134927 2892187 KLLA0_C01694g Kluyveromyces lactis uncharacterized protein XP_452271.1 133089 D 28985 CDS KLLA0_C01716g 2892545 135681..138188 C 1 NC_006039.1 weakly similar to Saccharomyces cerevisiae YLR177W Hypothetical ORF and to YDR505C uniprot|P50896 Saccharomyces cerevisiae YDR505C PSP1 Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; uncharacterized protein 138188 2892545 KLLA0_C01716g Kluyveromyces lactis uncharacterized protein XP_452272.1 135681 D 28985 CDS KLLA0_C01738g 2892252 complement(138679..139272) C 1 NC_006039.1 similar to uniprot|P14306 Saccharomyces cerevisiae YLR178C TFS1 Carboxypeptidase Y inhibitor (putative) lipid binding protein supressor of a cdc25 mutation; uncharacterized protein 139272 2892252 KLLA0_C01738g Kluyveromyces lactis uncharacterized protein XP_452273.1 138679 R 28985 CDS KLLA0_C01760g 2892250 139887..140798 C 1 NC_006039.1 similar to uniprot|Q04396 Saccharomyces cerevisiae YDR503C LPP1 Lipid phosphate phosphatase catalyzes Mg(2)-independent dephosphorylation of phosphatidic acid (PA) lysophosphatidic acid and diacylglycerol pyrophosphate involved in control of the cellular levels of phosphatidylinositol and PA; phosphatidate phosphatase LPP1 140798 2892250 KLLA0_C01760g Kluyveromyces lactis phosphatidate phosphatase LPP1 XP_452274.1 139887 D 28985 CDS KLLA0_C01782g 2892009 141519..142673 C 1 NC_006039.1 highly similar to uniprot|P10659 Saccharomyces cerevisiae YLR180W and to uniprot|P19358 Saccharomyces cerevisiae YDR502C SAM1 S-adenosylmethionine synthetase catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine one of two differentially regulated isozymes (Sam1p and Sam2p); uncharacterized protein 142673 2892009 KLLA0_C01782g Kluyveromyces lactis uncharacterized protein XP_452275.1 141519 D 28985 CDS KLLA0_C01804g 2892367 complement(143120..144034) C 1 NC_006039.1 similar to uniprot|Q07057 Saccharomyces cerevisiae YLR181C VTA1 Protein involved in endosomal protein sorting binds to Vps20 and Vps4 and may regulate Vps4function has coiled- coil domains mutants show class E vacuolar-protein sorting defects; uncharacterized protein 144034 2892367 KLLA0_C01804g Kluyveromyces lactis uncharacterized protein XP_452276.1 143120 R 28985 CDS KLLA0_C01826g 2892682 144307..146532 C 1 NC_006039.1 uniprot|P40418 Kluyveromyces lactis Regulatory protein SWI6 (Cell-cycle box factor, chain SWI6) (Trans-acting activator of HO endonuclease gene) (MBF subunit P90); transcriptional regulator SWI6 146532 2892682 KLLA0_C01826g Kluyveromyces lactis transcriptional regulator SWI6 XP_452277.1 144307 D 28985 CDS KLLA0_C01848g 2891917 complement(146739..148310) C 1 NC_006039.1 similar to uniprot|Q04383 Saccharomyces cerevisiae YDR501W PLM2 Plasmid Maintenance and to uniprot|Q06266 YLR183C Saccharomyces cerevisiae TOS4 Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF; uncharacterized protein 148310 2891917 KLLA0_C01848g Kluyveromyces lactis uncharacterized protein XP_452278.1 146739 R 28985 CDS KLLA0_C01870g 2892544 join(148935..148941,149449..149708) C 1 NC_006039.1 highly similar to uniprot|P49166 Saccharomyces cerevisiae YLR185W RPL37A protein and to uniprot|P51402 Saccharomyces cerevisiae YDR500C RPL37B protein, components of the large (60S) ribosomal subunit; 60S ribosomal protein eL37 149708 2892544 KLLA0_C01870g Kluyveromyces lactis 60S ribosomal protein eL37 XP_452279.1 148935 D 28985 CDS KLLA0_C01892g 2892543 complement(149917..151911) C 1 NC_006039.1 weakly similar to uniprot|Q04377 Saccharomyces cerevisiae YDR499W LCD1 Essential protein required for the DNA integrity checkpoint pathways interacts physically with Mec1p putative homolog of S. pombe Rad26 and human ATRIP; uncharacterized protein 151911 2892543 KLLA0_C01892g Kluyveromyces lactis uncharacterized protein XP_452280.1 149917 R 28985 CDS KLLA0_C01914g 2891832 152834..153592 C 1 NC_006039.1 highly similar to uniprot|Q06287 Saccharomyces cerevisiae YLR186W EMG1 Protein required for the maturation of the 18S rRNA and for 40S ribosome production associated with spindle/microtubules nuclear localization depends on physical interaction with Nop14p may bind snoRNAs; uncharacterized protein 153592 2891832 KLLA0_C01914g Kluyveromyces lactis uncharacterized protein XP_452281.1 152834 D 28985 CDS KLLA0_C01936g 2892642 153971..155902 C 1 NC_006039.1 similar to uniprot|P53835 Saccharomyces cerevisiae YNL279W PRM1 Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating predicted to have 5 transmembrane segments and a coiled coil domain localizes to the shmoo tip regulated by Ste12p; pheromone-regulated protein PRM1 155902 2892642 KLLA0_C01936g Kluyveromyces lactis pheromone-regulated protein PRM1 XP_452282.1 153971 D 28985 CDS KLLA0_C01969g 2891946 157410..160460 C 1 NC_006039.1 similar to Saccharomyces cerevisiae YLR187W SKG3 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate and to YNL278W uniprot|P53836 Saccharomyces cerevisiae YNL278W CAF120 Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation; uncharacterized protein 160460 2891946 KLLA0_C01969g Kluyveromyces lactis uncharacterized protein XP_452284.1 157410 D 28985 CDS KLLA0_C01991g 2891811 160778..162898 C 1 NC_006039.1 similar to uniprot|P33310 Saccharomyces cerevisiae YLR188W MDL1 Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane mediates export of peptides generated upon proteolysis of mitochondrial proteins plays a role in the regulation of cellular resistance to oxidative stress; ATP-binding cassette permease MDL1 162898 2891811 KLLA0_C01991g Kluyveromyces lactis ATP-binding cassette permease MDL1 XP_452285.1 160778 D 28985 CDS KLLA0_C02013g 2891828 163538..165001 C 1 NC_006039.1 similar to uniprot|P08465 Saccharomyces cerevisiae YNL277W MET2 L-homoserine-O-acetyltransferase catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway; homoserine O-acetyltransferase 165001 2891828 KLLA0_C02013g Kluyveromyces lactis homoserine O-acetyltransferase XP_452286.1 163538 D 28985 CDS KLLA0_C02035g 2891856 complement(165312..168941) C 1 NC_006039.1 similar to uniprot|Q06321 Saccharomyces cerevisiae YLR189C ATG26 UDP-glucose:sterol glucosyltransferase conserved enzyme involved in synthesis of sterol glucoside membrane lipids involved in autophagy; sterol 3-beta-glucosyltransferase 168941 2891856 KLLA0_C02035g Kluyveromyces lactis sterol 3-beta-glucosyltransferase XP_452287.1 165312 R 28985 CDS KLLA0_C02057g 2892356 complement(169406..170758) C 1 NC_006039.1 similar to uniprot|P40015 Saccharomyces cerevisiae YER019W ISC1 Inositol phosphosphingolipid phospholipase C hydrolyzes inositolphosphosphingolipids activated by phosphatidylserine cardiolipin and phosphatidylglycerol mediates Na and Li halotolerance contains a P loop-like domain; inositol phosphosphingolipid phospholipase 170758 2892356 KLLA0_C02057g Kluyveromyces lactis inositol phosphosphingolipid phospholipase XP_452288.1 169406 R 28985 CDS KLLA0_C02079g 2892694 join(171259..171463,171564..172042) C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 172042 2892694 KLLA0_C02079g Kluyveromyces lactis uncharacterized protein XP_452289.1 171259 D 28985 CDS KLLA0_C02101g 2892370 172317..173351 C 1 NC_006039.1 similar to uniprot|P25625 Saccharomyces cerevisiae YCR044C PER1 Vacuolar membrane protein that seems to be involved in Mn2 homeostasis mutant is dependent on activation of the unfolded protein response pathway for viability; uncharacterized protein 173351 2892370 KLLA0_C02101g Kluyveromyces lactis uncharacterized protein XP_452290.1 172317 D 28985 CDS KLLA0_C02123g 2892350 173935..175614 C 1 NC_006039.1 similar to uniprot|P53838 Saccharomyces cerevisiae YNL275W; uncharacterized protein 175614 2892350 KLLA0_C02123g Kluyveromyces lactis uncharacterized protein XP_452291.1 173935 D 28985 CDS KLLA0_C02145g 2892435 175962..176348 C 1 NC_006039.1 some similarities with uniprot|P25361 Saccharomyces cerevisiae YCR043C Hypothetical ORF; uncharacterized protein 176348 2892435 KLLA0_C02145g Kluyveromyces lactis uncharacterized protein XP_452292.1 175962 D 28985 CDS KLLA0_C02167g 2892538 complement(176570..177619) C 1 NC_006039.1 similar to uniprot|P53839 Saccharomyces cerevisiae YNL274C Putative hydroxyisocaproate dehydrogenase; glyoxylate reductase 177619 2892538 KLLA0_C02167g Kluyveromyces lactis glyoxylate reductase XP_452293.1 176570 R 28985 CDS KLLA0_C02189g 2892248 178544..182686 C 1 NC_006039.1 similar to uniprot|P23255 Saccharomyces cerevisiae YCR042C TAF2 TFIID subunit (150 kDa) involved in RNA polymerase II transcription initiation; uncharacterized protein 182686 2892248 KLLA0_C02189g Kluyveromyces lactis uncharacterized protein XP_452294.1 178544 D 28985 CDS KLLA0_C02211g 2892530 182975..184675 C 1 NC_006039.1 similar to uniprot|Q12232 Saccharomyces cerevisiae YOR154W Hypothetical ORF; uncharacterized protein 184675 2892530 KLLA0_C02211g Kluyveromyces lactis uncharacterized protein XP_452295.1 182975 D 28985 CDS KLLA0_C02233g 2892433 complement(184908..186374) C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 186374 2892433 KLLA0_C02233g Kluyveromyces lactis uncharacterized protein XP_452296.1 184908 R 28985 CDS KLLA0_C02255g 2892434 189083..192571 C 1 NC_006039.1 similar to uniprot|P53840 Saccharomyces cerevisiae YNL273W TOF1 Protein that interacts with topoisomerase I; uncharacterized protein 192571 2892434 KLLA0_C02255g Kluyveromyces lactis uncharacterized protein XP_452297.1 189083 D 28985 CDS KLLA0_C02277g 2892529 complement(192607..194004) C 1 NC_006039.1 similar to uniprot|P39981 Saccharomyces cerevisiae YEL064C AVT2 Putative transporter member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; uncharacterized protein 194004 2892529 KLLA0_C02277g Kluyveromyces lactis uncharacterized protein XP_452298.1 192607 R 28985 CDS KLLA0_C02299g 2892539 complement(194267..196243) C 1 NC_006039.1 similar to uniprot|P17065 Saccharomyces cerevisiae YNL272C SEC2 Guanyl-nucleotide exchange factor for the small G-protein Sec4p located on cytoplasmic vesicles essential for post-Golgi vesicle transport; guanine nucleotide exchange factor SEC2 196243 2892539 KLLA0_C02299g Kluyveromyces lactis guanine nucleotide exchange factor SEC2 XP_452299.1 194267 R 28985 CDS KLLA0_C02321g 2892528 complement(196533..202061) C 1 NC_006039.1 similar to uniprot|P41832 Saccharomyces cerevisiae YNL271C BNI1 Formin nucleates the formation of linear actin filaments involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables functionally redundant with BNR1; formin BNI1 202061 2892528 KLLA0_C02321g Kluyveromyces lactis formin BNI1 XP_452300.1 196533 R 28985 CDS KLLA0_C02343g 2892430 complement(203552..205297) C 1 NC_006039.1 similar to uniprot|P04817 Saccharomyces cerevisiae YEL063C CAN1 Plasma membrane arginine permease requires phosphatidyl ethanolamine (PE) for localization exclusively associated with lipid rafts mutation confers canavanine resistance; uncharacterized protein 205297 2892430 KLLA0_C02343g Kluyveromyces lactis uncharacterized protein XP_452301.1 203552 R 28985 CDS KLLA0_C02365g 2892531 208462..210201 C 1 NC_006039.1 similar to uniprot|P32487 Saccharomyces cerevisiae YNL268W LYP1 Lysine permease one of three amino acid permeases (Alp1p Can1p Lyp1p) responsible for uptake of cationic amino acids; lysine permease 210201 2892531 KLLA0_C02365g Kluyveromyces lactis lysine permease XP_452302.1 208462 D 28985 CDS KLLA0_C02387g 2892536 211012..213882 C 1 NC_006039.1 similar to uniprot|P39104 Saccharomyces cerevisiae YNL267W PIK1 Phosphatidylinositol 4-kinase catalyzes first step in the biosynthesis of phosphatidylinositol-4 5-biphosphate may control cytokineses through the actin cytoskeleton; 1-phosphatidylinositol 4-kinase 213882 2892536 KLLA0_C02387g Kluyveromyces lactis 1-phosphatidylinositol 4-kinase XP_452303.1 211012 D 28985 CDS KLLA0_C02409g 2892537 214337..215518 C 1 NC_006039.1 similar to uniprot|P53230 Saccharomyces cerevisiae YGR046W Essential protein of unknown function mRNA is targeted to the bud via the mRNA transport system involving She2p; uncharacterized protein 215518 2892537 KLLA0_C02409g Kluyveromyces lactis uncharacterized protein XP_452304.1 214337 D 28985 CDS KLLA0_C02431g 2892387 complement(215644..216465) C 1 NC_006039.1 similar to uniprot|P53843 Saccharomyces cerevisiae YNL265C IST1 Putative translation initiation factor as suggested by computational analysis of large-scale protein-protein interaction data; uncharacterized protein 216465 2892387 KLLA0_C02431g Kluyveromyces lactis uncharacterized protein XP_452305.2 215644 R 28985 CDS KLLA0_C02453g 2892432 complement(216740..219826) C 1 NC_006039.1 similar to uniprot|P33339 Saccharomyces cerevisiae YGR047C; transcription factor TFIIIC subunit TFC4 219826 2892432 KLLA0_C02453g Kluyveromyces lactis transcription factor TFIIIC subunit TFC4 XP_452306.1 216740 R 28985 CDS KLLA0_C02475g 2892535 220395..221432 C 1 NC_006039.1 highly similar to uniprot|P53044 Saccharomyces cerevisiae YGR048W UFD1 Protein that interacts with Cdc48p and Npl4p involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation involved in transporting proteins from the ER to the cytosol; polyubiquitin-binding protein UFD1 221432 2892535 KLLA0_C02475g Kluyveromyces lactis polyubiquitin-binding protein UFD1 XP_452307.1 220395 D 28985 CDS KLLA0_C02497g 2892431 complement(221470..225054) C 1 NC_006039.1 similar to uniprot|P53120 Saccharomyces cerevisiae YGL140C Hypothetical ORF; uncharacterized protein 225054 2892431 KLLA0_C02497g Kluyveromyces lactis uncharacterized protein XP_452308.1 221470 R 28985 CDS KLLA0_C02519g 2892534 complement(225470..226489) C 1 NC_006039.1 similar to uniprot|P53844 Saccharomyces cerevisiae YNL264C PDR17 Phosphatidylinositol transfer protein (PITP) downregulates Plb1p-mediated turnover of phosphatidylcholine found in the cytosol and microsomes homologous to Pdr16p deletion affects phospholipid composition; phosphatidylinositol transporter 226489 2892534 KLLA0_C02519g Kluyveromyces lactis phosphatidylinositol transporter XP_452309.1 225470 R 28985 CDS KLLA0_C02541g 2892427 complement(226721..227533) C 1 NC_006039.1 weakly similar to uniprot|P52868 Saccharomyces cerevisiae YGL128C; U2-type spliceosomal complex subunit CWC23 227533 2892427 KLLA0_C02541g Kluyveromyces lactis U2-type spliceosomal complex subunit CWC23 XP_452310.1 226721 R 28985 CDS KLLA0_C02563g 2892533 complement(227814..228731) C 1 NC_006039.1 similar to uniprot|P53845 Saccharomyces cerevisiae YNL263C; protein transporter YIF1 228731 2892533 KLLA0_C02563g Kluyveromyces lactis protein transporter YIF1 XP_452311.1 227814 R 28985 CDS KLLA0_C02585g 2892428 229274..235831 C 1 NC_006039.1 similar to uniprot|P21951 Saccharomyces cerevisiae YNL262W POL2 Catalytic subunit of DNA polymerase epsilon one of the major chromosomal DNA replication polymerases characterized by processivity and proofreading exonuclease activity also involved in DNA synthesis during DNA repair; DNA polymerase epsilon catalytic subunit 235831 2892428 KLLA0_C02585g Kluyveromyces lactis DNA polymerase epsilon catalytic subunit XP_452312.1 229274 D 28985 CDS KLLA0_C02607g 2892429 236042..237463 C 1 NC_006039.1 similar to uniprot|P50874 Saccharomyces cerevisiae YNL261W ORC5 Subunit of the origin recognition complex which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; origin recognition complex subunit 5 237463 2892429 KLLA0_C02607g Kluyveromyces lactis origin recognition complex subunit 5 XP_452313.1 236042 D 28985 CDS KLLA0_C02629g 2892532 237655..238632 C 1 NC_006039.1 some similarities with uniprot|P38852 Saccharomyces cerevisiae YHR156C LIN1 Nuclear protein that physically interacts with Irr1p a component of the cohesin complex may link together proteins involved in chromosome segregation mRNA splicing and DNA replication; U5 snRNP complex subunit LIN1 238632 2892532 KLLA0_C02629g Kluyveromyces lactis U5 snRNP complex subunit LIN1 XP_452314.1 237655 D 28985 CDS KLLA0_C02651g 2891818 complement(238695..239189) C 1 NC_006039.1 weakly similar to uniprot|P53846 Saccharomyces cerevisiae YNL260C Protein required for cell viability; ribosome biosynthesis protein LTO1 239189 2891818 KLLA0_C02651g Kluyveromyces lactis ribosome biosynthesis protein LTO1 XP_452315.1 238695 R 28985 CDS KLLA0_C02673g 2892489 complement(239589..239813) C 1 NC_006039.1 highly similar to uniprot|P38636 Saccharomyces cerevisiae YNL259C ATX1 Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake; copper metallochaperone ATX1 239813 2892489 KLLA0_C02673g Kluyveromyces lactis copper metallochaperone ATX1 XP_452316.1 239589 R 28985 CDS KLLA0_C02695g 2891911 complement(240212..242272) C 1 NC_006039.1 weakly similar to uniprot|P53847 Saccharomyces cerevisiae YNL258C DSL1 Endoplasmic reticulum (ER)-localized peripheral membrane protein required for Golgi-to-ER retrograde traffic component of the ER target site that interacts with coatomer the major component of the COPI vesicle protein coat; uncharacterized protein 242272 2891911 KLLA0_C02695g Kluyveromyces lactis uncharacterized protein XP_452317.1 240212 R 28985 CDS KLLA0_C02717g 2892546 complement(242948..246508) C 1 NC_006039.1 similar to uniprot|P38717 Saccharomyces cerevisiae YNL257C SIP3 Protein that activates transcription through interaction with DNA-bound Snf1p C-terminal region has a putative leucine zipper motif potential Cdc28p substrate and to uniprot|P38851 Saccharomyces cerevisiae YHR155W YSP1 Hypothetical ORF; uncharacterized protein 246508 2892546 KLLA0_C02717g Kluyveromyces lactis uncharacterized protein XP_452318.1 242948 R 28985 CDS KLLA0_C02739g 2891814 complement(246771..247952) C 1 NC_006039.1 similar to uniprot|P54857 Saccharomyces cerevisiae YDR058C TGL2 Triglyceride Lipase; triglyceride lipase 247952 2891814 KLLA0_C02739g Kluyveromyces lactis triglyceride lipase XP_452319.1 246771 R 28985 CDS KLLA0_C02761g 2892542 complement(248365..249783) C 1 NC_006039.1 similar to uniprot|P53318 Saccharomyces cerevisiae YGR255C COQ6 Putative flavin-dependent monooxygenase involved in ubiquinone (Coenzyme Q) biosynthesis located on the matrix side of the mitochondrial inner membrane; uncharacterized protein 249783 2892542 KLLA0_C02761g Kluyveromyces lactis uncharacterized protein XP_452320.1 248365 R 28985 CDS KLLA0_C02783g 2892221 250633..253029 C 1 NC_006039.1 similar to uniprot|P53848 Saccharomyces cerevisiae YNL256W FOL1 Multifunctional enzyme of the folic acid biosynthesis pathway has dihydropteroate synthetase dihydro-6-hydroxymethylpterin pyrophosphokinase and dihydroneopterin aldolase activities; trifunctional dihydropteroate synthetase/dihydrohydroxymethylpterin pyrophosphokinase/dihydroneopterin aldolase FOL1 253029 2892221 KLLA0_C02783g Kluyveromyces lactis trifunctional dihydropteroate synthetase/dihydrohydroxymethylpterin pyrophosphokinase/dihydroneopterin aldolase FOL1 XP_452321.1 250633 D 28985 CDS KLLA0_C02805g 2892292 complement(253320..253790) C 1 NC_006039.1 highly similar to uniprot|P53849 Saccharomyces cerevisiae YNL255C; mRNA-binding translational activator GIS2 253790 2892292 KLLA0_C02805g Kluyveromyces lactis mRNA-binding translational activator GIS2 XP_452322.1 253320 R 28985 CDS KLLA0_C02827g 2891851 complement(254087..255217) C 1 NC_006039.1 some similarities with uniprot|P53850 Saccharomyces cerevisiae YNL254C Hypothetical ORF; uncharacterized protein 255217 2891851 KLLA0_C02827g Kluyveromyces lactis uncharacterized protein XP_452323.1 254087 R 28985 CDS KLLA0_C02849g 2892385 255963..257285 C 1 NC_006039.1 some similarities with uniprot|P53851 Saccharomyces cerevisiae YNL253W TEX1 transcription export complex component; uncharacterized protein 257285 2892385 KLLA0_C02849g Kluyveromyces lactis uncharacterized protein XP_452324.1 255963 D 28985 CDS KLLA0_C02871g 2892389 complement(257493..258284) C 1 NC_006039.1 similar to uniprot|P36528 Saccharomyces cerevisiae YNL252C MRPL17 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein mL46 258284 2892389 KLLA0_C02871g Kluyveromyces lactis mitochondrial 54S ribosomal protein mL46 XP_452325.1 257493 R 28985 CDS KLLA0_C02893g 2892294 complement(258602..260473) C 1 NC_006039.1 similar to uniprot|P53617 Saccharomyces cerevisiae YNL251C NRD1 RNA-binding protein that interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p) required for transcription termination and 3' end maturation of nonpolyadenylated RNAs; Nrd1 complex RNA-binding subunit 260473 2892294 KLLA0_C02893g Kluyveromyces lactis Nrd1 complex RNA-binding subunit XP_452326.1 258602 R 28985 CDS KLLA0_C02915g 2892233 261280..265170 C 1 NC_006039.1 similar to uniprot|P12753 Saccharomyces cerevisiae YNL250W RAD50 Subunit of MRX complex with Mre11p and Xrs2p involved in processing double-strand DNA breaks in vegetative cells initiation of meiotic DSBs telomere maintenance and nonhomologous end joining; MRX complex DNA-binding subunit 265170 2892233 KLLA0_C02915g Kluyveromyces lactis MRX complex DNA-binding subunit XP_452327.1 261280 D 28985 CDS KLLA0_C02937g 2892660 complement(265205..266755) C 1 NC_006039.1 similar to uniprot|P53583 Saccharomyces cerevisiae YNL249C MPA43 Mitochondrial protein of unknown function and similar to uniprot|Q04585 Saccharomyces cerevisiae YDR109C Hypothetical ORF; uncharacterized protein 266755 2892660 KLLA0_C02937g Kluyveromyces lactis uncharacterized protein XP_452328.1 265205 R 28985 CDS KLLA0_C02959g 2892293 complement(266971..268209) C 1 NC_006039.1 similar to uniprot|Q01080 Saccharomyces cerevisiae YNL248C RPA49 RNA polymerase I subunit A49; DNA-directed RNA polymerase I subunit RPA49 268209 2892293 KLLA0_C02959g Kluyveromyces lactis DNA-directed RNA polymerase I subunit RPA49 XP_452329.1 266971 R 28985 CDS KLLA0_C02981g 2892229 268669..269157 C 1 NC_006039.1 similar to uniprot|P47138 Saccharomyces cerevisiae YJR097W JJJ3 Protein required along with Dph1p Dph2p Kti11p and Dph5p for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) contains a DnaJ-like domain; uncharacterized protein 269157 2892229 KLLA0_C02981g Kluyveromyces lactis uncharacterized protein XP_452330.1 268669 D 28985 CDS KLLA0_C03003g 2892262 complement(269315..271279) C 1 NC_006039.1 similar to uniprot|P47139 Saccharomyces cerevisiae YJR098C Hypothetical ORF; uncharacterized protein 271279 2892262 KLLA0_C03003g Kluyveromyces lactis uncharacterized protein XP_452331.1 269315 R 28985 CDS KLLA0_C03025g 2892083 271793..274093 C 1 NC_006039.1 similar to uniprot|P53852 Saccharomyces cerevisiae YNL247W Protein required for cell viability; cysteine--tRNA ligase 274093 2892083 KLLA0_C03025g Kluyveromyces lactis cysteine--tRNA ligase XP_452332.1 271793 D 28985 CDS KLLA0_C03047g 2892226 join(274325..274347,274440..275247) C 1 NC_006039.1 similar to uniprot|P53853 Saccharomyces cerevisiae YNL246W VPS75; uncharacterized protein 275247 2892226 KLLA0_C03047g Kluyveromyces lactis uncharacterized protein XP_452333.1 274325 D 28985 CDS KLLA0_C03069g 2892264 complement(275322..275942) C 1 NC_006039.1 weakly similar to uniprot|P53854 Saccharomyces cerevisiae YNL245C; U2-type spliceosomal complex subunit CWC25 275942 2892264 KLLA0_C03069g Kluyveromyces lactis U2-type spliceosomal complex subunit CWC25 XP_452334.1 275322 R 28985 CDS KLLA0_C03091g 2892223 complement(276491..276817) C 1 NC_006039.1 highly similar to uniprot|P32911 Saccharomyces cerevisiae YNL244C SUI1 translation initiation factor eIF1; translation initiation factor eIF1 276817 2892223 KLLA0_C03091g Kluyveromyces lactis translation initiation factor eIF1 XP_452335.1 276491 R 28985 CDS KLLA0_C03113g 2892170 277789..279804 C 1 NC_006039.1 uniprot|Q707Z3 Kluyveromyces lactis KLLA0C03113g Sla2 protein; uncharacterized protein 279804 2892170 KLLA0_C03113g Kluyveromyces lactis uncharacterized protein XP_452336.1 277789 D 28985 CDS KLLA0_C03135g 2892130 complement(279869..280555) C 1 NC_006039.1 highly similar to uniprot|Q9HG12 Kluyveromyces lactis KLLA0B14553g HMRA1 Mating-type protein A1; uncharacterized protein 280555 2892130 KLLA0_C03135g Kluyveromyces lactis uncharacterized protein XP_452337.1 279869 R 28985 CDS KLLA0_C03157g 2892068 281410..282183 C 1 NC_006039.1 highly similar to uniprot|Q9HG13 Kluyveromyces lactis KLLA0B14575g HMRA2 Mating-type protein A2; uncharacterized protein 282183 2892068 KLLA0_C03157g Kluyveromyces lactis uncharacterized protein XP_452338.1 281410 D 28985 CDS KLLA0_C03179g 2892005 complement(282251..286687) C 1 NC_006039.1 weakly similar to uniprot|P39526 Saccharomyces cerevisiae YJL207C Hypothetical ORF; uncharacterized protein 286687 2892005 KLLA0_C03179g Kluyveromyces lactis uncharacterized protein XP_452339.1 282251 R 28985 CDS KLLA0_C03201g 2892374 complement(286973..288925) C 1 NC_006039.1 similar to uniprot|P39529 Saccharomyces cerevisiae YJL206C and some similarities with YIL130W uniprot|P40467 Saccharomyces cerevisiae YIL130W ASG1 Proposed transcriptional activator member of the Gal4p family of zinc cluster proteins; uncharacterized protein 288925 2892374 KLLA0_C03201g Kluyveromyces lactis uncharacterized protein XP_452340.1 286973 R 28985 CDS KLLA0_C03256g 2891803 295057..295449 C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 295449 2891803 KLLA0_C03256g Kluyveromyces lactis uncharacterized protein XP_452343.1 295057 D 28985 CDS KLLA0_C03278g 2892197 295796..296806 C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 296806 2892197 KLLA0_C03278g Kluyveromyces lactis uncharacterized protein XP_452344.1 295796 D 28985 CDS KLLA0_C03300g 2892587 complement(296848..299328) C 1 NC_006039.1 similar to uniprot|P39531 Saccharomyces cerevisiae YJL204C RCY1 ReCYcling 1; uncharacterized protein 299328 2892587 KLLA0_C03300g Kluyveromyces lactis uncharacterized protein XP_452345.1 296848 R 28985 CDS KLLA0_C03322g 2891870 299405..300562 C 1 NC_006039.1 similar to uniprot|P32524 Saccharomyces cerevisiae YJL203W PRP21 Subunit of the SF3a splicing factor complex required for spliceosome assembly; uncharacterized protein 300562 2891870 KLLA0_C03322g Kluyveromyces lactis uncharacterized protein XP_452346.1 299405 D 28985 CDS KLLA0_C03388g 2891872 301679..303421 C 1 NC_006039.1 similar to uniprot|P32525 Saccharomyces cerevisiae YJL201W ECM25 Non-essential protein of unknown function promoter contains a consensus binding sequence for factor Abf1p; uncharacterized protein 303421 2891872 KLLA0_C03388g Kluyveromyces lactis uncharacterized protein XP_452347.1 301679 D 28985 CDS KLLA0_C03410g 2891855 303739..307821 C 1 NC_006039.1 some similarities with uniprot|P25300 Saccharomyces cerevisiae YCR038C BUD5 GTP/GDP exchange factor for Rsr1p (Bud1p) required for both axial and bipolar budding patterns; Ras family guanine nucleotide exchange factor BUD5 307821 2891855 KLLA0_C03410g Kluyveromyces lactis Ras family guanine nucleotide exchange factor BUD5 XP_452348.1 303739 D 28985 CDS KLLA0_C03432g 2892663 complement(308036..310423) C 1 NC_006039.1 highly similar to uniprot|P39533 Saccharomyces cerevisiae YJL200C Hypothetical ORF; aconitate hydratase ACO2 310423 2892663 KLLA0_C03432g Kluyveromyces lactis aconitate hydratase ACO2 XP_452349.1 308036 R 28985 CDS KLLA0_C03454g 2892352 311611..314313 C 1 NC_006039.1 similar to uniprot|P25360 Saccharomyces cerevisiae YCR037C PHO87 Low-affinity inorganic phosphate (Pi) transporter involved in activation of PHO pathway expression is independent of Pi concentration and Pho4p activity contains 12 membrane-spanning segments and to uniprot|P39535 Saccharomyces cerevisiae YJL198W PHO90; SPX domain-containing inorganic phosphate transporter 314313 2892352 KLLA0_C03454g Kluyveromyces lactis SPX domain-containing inorganic phosphate transporter XP_452350.1 311611 D 28985 CDS KLLA0_C03476g 2892382 314815..318573 C 1 NC_006039.1 similar to uniprot|P39538 Saccharomyces cerevisiae YJL197W UBP12 Ubiquitin-specific protease present in the nucleus and cytoplasm that cleaves ubiquitin from ubiquitinated proteins; uncharacterized protein 318573 2892382 KLLA0_C03476g Kluyveromyces lactis uncharacterized protein XP_452351.1 314815 D 28985 CDS KLLA0_C03498g 2891971 complement(318733..319734) C 1 NC_006039.1 similar to uniprot|P25332 Saccharomyces cerevisiae YCR036W RBK1 Putative ribokinase; uncharacterized protein 319734 2891971 KLLA0_C03498g Kluyveromyces lactis uncharacterized protein XP_452352.1 318733 R 28985 CDS KLLA0_C03520g 2892140 320298..321437 C 1 NC_006039.1 similar to uniprot|P25359 Saccharomyces cerevisiae YCR035C RRP43 Ribosomal RNA Processing; exosome non-catalytic core subunit RRP43 321437 2892140 KLLA0_C03520g Kluyveromyces lactis exosome non-catalytic core subunit RRP43 XP_452353.1 320298 D 28985 CDS KLLA0_C03542g 2892081 complement(321724..322785) C 1 NC_006039.1 similar to uniprot|P25358 Saccharomyces cerevisiae YCR034W FEN1 Fatty acid elongase involved in sphingolipid biosynthesis acts on fatty acids of up to 24 carbons in length mutations have regulatory effects on 1 3-beta-glucan synthase vacuolar ATPase and the secretory pathway; uncharacterized protein 322785 2892081 KLLA0_C03542g Kluyveromyces lactis uncharacterized protein XP_452354.1 321724 R 28985 CDS KLLA0_C03564g 2891820 complement(323354..327553) C 1 NC_006039.1 some similarities with uniprot|P25357 Saccharomyces cerevisiae YCR033W SNT1; uncharacterized protein 327553 2891820 KLLA0_C03564g Kluyveromyces lactis uncharacterized protein XP_452355.1 323354 R 28985 CDS KLLA0_C03586g 2891808 328910..330481 C 1 NC_006039.1 similar to uniprot|P09119 Saccharomyces cerevisiae YJL194W CDC6 Essential ATP-binding protein required for DNA replication component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association homologous to S. pombe Cdc18p; AAA family ATPase CDC6 330481 2891808 KLLA0_C03586g Kluyveromyces lactis AAA family ATPase CDC6 XP_452356.1 328910 D 28985 CDS KLLA0_C03608g 2891890 330900..331577 C 1 NC_006039.1 similar to uniprot|Q03390 Saccharomyces cerevisiae YDR486C VPS60 vacuolar protein sorting (putative); uncharacterized protein 331577 2891890 KLLA0_C03608g Kluyveromyces lactis uncharacterized protein XP_452357.1 330900 D 28985 CDS KLLA0_C03630g 2891824 complement(331750..332733) C 1 NC_006039.1 similar to uniprot|P27680 Saccharomyces cerevisiae YOL096C; hexaprenyldihydroxybenzoate methyltransferase 332733 2891824 KLLA0_C03630g Kluyveromyces lactis hexaprenyldihydroxybenzoate methyltransferase XP_452358.1 331750 R 28985 CDS KLLA0_C03652g 2892405 333038..335155 C 1 NC_006039.1 some similarities with uniprot|Q03388 Saccharomyces cerevisiae YDR485C VPS72 Protein of unknown function component of the Swr1p complex that incorporates Htz1p into chromatin required for vacuolar protein sorting; uncharacterized protein 335155 2892405 KLLA0_C03652g Kluyveromyces lactis uncharacterized protein XP_452359.1 333038 D 28985 CDS KLLA0_C03674g 2892288 complement(335163..337289) C 1 NC_006039.1 similar to uniprot|Q05379 Saccharomyces cerevisiae YOL095C HMI1 Mitochondrial inner membrane localized ATP-dependent DNA helicase required for the maintenance of the mitochondrial genome not required for mitochondrial transcription; ATP-dependent 3'-5' DNA helicase 337289 2892288 KLLA0_C03674g Kluyveromyces lactis ATP-dependent 3'-5' DNA helicase XP_452360.1 335163 R 28985 CDS KLLA0_C03696g 2892413 complement(337551..339335) C 1 NC_006039.1 similar to uniprot|P39904 Saccharomyces cerevisiae YDR484W; uncharacterized protein 339335 2892413 KLLA0_C03696g Kluyveromyces lactis uncharacterized protein XP_452361.1 337551 R 28985 CDS KLLA0_C03718g 2892422 complement(339645..340607) C 1 NC_006039.1 highly similar to uniprot|P40339 Saccharomyces cerevisiae YOL094C RFC4 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; replication factor C subunit 4 340607 2892422 KLLA0_C03718g Kluyveromyces lactis replication factor C subunit 4 XP_452362.1 339645 R 28985 CDS KLLA0_C03740g 2892404 341104..342000 C 1 NC_006039.1 similar to uniprot|Q12400 Saccharomyces cerevisiae YOL093W; tRNA (guanine(9)-N(1))-methyltransferase 342000 2892404 KLLA0_C03740g Kluyveromyces lactis tRNA (guanine(9)-N(1))-methyltransferase XP_452363.1 341104 D 28985 CDS KLLA0_C03762g 2892409 342637..343557 C 1 NC_006039.1 similar to uniprot|Q12010 YOL092W Saccharomyces cerevisiae Hypothetical ORF; cationic amino acid transporter 343557 2892409 KLLA0_C03762g Kluyveromyces lactis cationic amino acid transporter XP_452364.1 342637 D 28985 CDS KLLA0_C03784g 2892275 344101..345969 C 1 NC_006039.1 weakly similar to uniprot|Q06704 Saccharomyces cerevisiae YLR309C IMH1 Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi; uncharacterized protein 345969 2892275 KLLA0_C03784g Kluyveromyces lactis uncharacterized protein XP_452365.1 344101 D 28985 CDS KLLA0_C03806g 2892661 346318..348768 C 1 NC_006039.1 weakly similar to uniprot|Q7LGP7 Saccharomyces cerevisiae YOL063C HUS1; uncharacterized protein 348768 2892661 KLLA0_C03806g Kluyveromyces lactis uncharacterized protein XP_452366.1 346318 D 28985 CDS KLLA0_C03828g 2892668 349187..351568 C 1 NC_006039.1 similar to uniprot|P54199 Saccharomyces cerevisiae YDL028C MPS1 Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function substrates include SPB proteins Spc42p Spc110p and Spc98p mitotic exit network protein Mob1p and checkpoint protein Mad1p; serine/threonine/tyrosine protein kinase MPS1 351568 2892668 KLLA0_C03828g Kluyveromyces lactis serine/threonine/tyrosine protein kinase MPS1 XP_452367.1 349187 D 28985 CDS KLLA0_C03850g 2892200 complement(351772..352947) C 1 NC_006039.1 highly similar to uniprot|P32381 Saccharomyces cerevisiae YDL029W ARP2 Essential component of the Arp2/3 complex which is a highly conserved actin nucleation center required for the motility and integrity of actin patches involved in endocytosis and membrane growth and polarity; actin-related protein 2 352947 2892200 KLLA0_C03850g Kluyveromyces lactis actin-related protein 2 XP_452368.1 351772 R 28985 CDS KLLA0_C03872g 2892411 complement(353385..354515) C 1 NC_006039.1 some similarities with uniprot|Q7LHC7 Saccharomyces cerevisiae YDL027C Hypothetical ORF; uncharacterized protein 354515 2892411 KLLA0_C03872g Kluyveromyces lactis uncharacterized protein XP_452369.1 353385 R 28985 CDS KLLA0_C03894g 2892403 complement(354889..356316) C 1 NC_006039.1 similar to uniprot|Q99186 Saccharomyces cerevisiae YOL062C APM4 Clathrin associated protein medium subunit; uncharacterized protein 356316 2892403 KLLA0_C03894g Kluyveromyces lactis uncharacterized protein XP_452370.1 354889 R 28985 CDS KLLA0_C03916g 2892212 357026..358432 C 1 NC_006039.1 similar to uniprot|Q12265 Saccharomyces cerevisiae YOL061W PRS5 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase involved in nucleotide histidine and tryptophan biosynthesis one of a five related enzymes which are active as heteromultimeric complexes; ribose phosphate diphosphokinase subunit PRS5 358432 2892212 KLLA0_C03916g Kluyveromyces lactis ribose phosphate diphosphokinase subunit PRS5 XP_452371.1 357026 D 28985 CDS KLLA0_C03938g 2892407 complement(358851..360632) C 1 NC_006039.1 some similarities with uniprot|Q12100 Saccharomyces cerevisiae YDL025C Protein of unknown function potentially phosphorylated by Cdc28p; uncharacterized protein 360632 2892407 KLLA0_C03938g Kluyveromyces lactis uncharacterized protein XP_452372.1 358851 R 28985 CDS KLLA0_C03960g 2892077 complement(361124..363154) C 1 NC_006039.1 similar to uniprot|Q12296 Saccharomyces cerevisiae YOL060C; uncharacterized protein 363154 2892077 KLLA0_C03960g Kluyveromyces lactis uncharacterized protein XP_452373.1 361124 R 28985 CDS KLLA0_C04004g 2892022 364969..366288 C 1 NC_006039.1 highly similar to uniprot|Q00055 Saccharomyces cerevisiae YDL022W GPD1 NAD-dependent glycerol-3-phosphate dehydrogenase key enzyme of glycerol synthesis essential for growth under osmotic stress expression regulated by high-osmolarity glycerol response pathway homolog of Gpd2p; uncharacterized protein 366288 2892022 KLLA0_C04004g Kluyveromyces lactis uncharacterized protein XP_452375.1 364969 D 28985 CDS KLLA0_C04037g 2892045 367627..368889 C 1 NC_006039.1 highly similar to uniprot|P22768 Saccharomyces cerevisiae YOL058W ARG1 Arginosuccinate synthetase catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway potential Cdc28p substrate; argininosuccinate synthase 368889 2892045 KLLA0_C04037g Kluyveromyces lactis argininosuccinate synthase XP_452377.1 367627 D 28985 CDS KLLA0_C04059g 2892314 369331..371340 C 1 NC_006039.1 similar to uniprot|Q08225 Saccharomyces cerevisiae YOL057W Hypothetical ORF; dipeptidyl-peptidase III 371340 2892314 KLLA0_C04059g Kluyveromyces lactis dipeptidyl-peptidase III XP_452378.1 369331 D 28985 CDS KLLA0_C04081g 2891825 371620..372480 C 1 NC_006039.1 similar to uniprot|Q12326 Saccharomyces cerevisiae YOL056W GPM3 and to YDL021W uniprot|Q12008 Saccharomyces cerevisiae YDL021W GPM2, Homologs of Gpm1p phosphoglycerate mutase which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; phosphoglycerate mutase family protein GPM3 372480 2891825 KLLA0_C04081g Kluyveromyces lactis phosphoglycerate mutase family protein GPM3 XP_452379.1 371620 D 28985 CDS KLLA0_C04103g 2892309 complement(372753..374447) C 1 NC_006039.1 weakly similar to uniprot|Q03465 Saccharomyces cerevisiae YDL020C RPN4 Transcription factor that stimulates expression of proteasome genes Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism RPN4 is transcriptionally regulated by various stress responses; stress-regulated transcription factor RPN4 374447 2892309 KLLA0_C04103g Kluyveromyces lactis stress-regulated transcription factor RPN4 XP_452380.1 372753 R 28985 CDS KLLA0_C04125g 2892306 375708..376982 C 1 NC_006039.1 weakly similar to uniprot|P47124 Saccharomyces cerevisiae YJR075W HOC1 Alpha-1 6-mannosyltransferase involved in cell wall mannan biosynthesis subunit of a Golgi-localized complex that also contains Anp1p Mnn9p Mnn11p and Mnn10p identified as a suppressor of a cell lysis sensitive pkc1-371 allele; uncharacterized protein 376982 2892306 KLLA0_C04125g Kluyveromyces lactis uncharacterized protein XP_452381.1 375708 D 28985 CDS KLLA0_C04147g 2891951 complement(377185..380907) C 1 NC_006039.1 similar to uniprot|Q12451 Saccharomyces cerevisiae YDL019C OSH2 Member of an oxysterol-binding protein family with seven members in S. cerevisiae family members have overlapping redundant functions in sterol metabolism and collectively perform a function essential for viability; uncharacterized protein 380907 2891951 KLLA0_C04147g Kluyveromyces lactis uncharacterized protein XP_452382.1 377185 R 28985 CDS KLLA0_C04169g 2892029 complement(381543..383621) C 1 NC_006039.1 similar to uniprot|P80235 YAR035W Saccharomyces cerevisiae YAT1 Outer carnitine acetyltransferase mitochondrial; carnitine O-acetyltransferase YAT1 383621 2892029 KLLA0_C04169g Kluyveromyces lactis carnitine O-acetyltransferase YAT1 XP_452383.1 381543 R 28985 CDS KLLA0_C04191g 2892038 384198..386591 C 1 NC_006039.1 weakly similar to uniprot|P27636 Saccharomyces cerevisiae YAR019C CDC15 Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase promotes mitotic exit by directly switching on the kinase activity of Dbf2p; serine/threonine protein kinase CDC15 386591 2892038 KLLA0_C04191g Kluyveromyces lactis serine/threonine protein kinase CDC15 XP_452384.1 384198 D 28985 CDS KLLA0_C04213g 2892166 386815..387999 C 1 NC_006039.1 similar to uniprot|P22209 Saccharomyces cerevisiae YAR018C KIN3 Nonessential protein kinase with unknown cellular role; serine/threonine protein kinase KIN3 387999 2892166 KLLA0_C04213g Kluyveromyces lactis serine/threonine protein kinase KIN3 XP_452385.1 386815 D 28985 CDS KLLA0_C04235g 2892265 complement(388102..389031) C 1 NC_006039.1 highly similar to uniprot|P27616 Saccharomyces cerevisiae YAR015W ADE1 N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase required for 'de novo' purine nucleotide biosynthesis red pigment accumulates in mutant cells deprived of adenin; phosphoribosylaminoimidazolesuccinocarboxamide synthase 389031 2892265 KLLA0_C04235g Kluyveromyces lactis phosphoribosylaminoimidazolesuccinocarboxamide synthase XP_452386.1 388102 R 28985 CDS KLLA0_C04257g 2892171 389812..391875 C 1 NC_006039.1 weakly similar to uniprot|P27637 Saccharomyces cerevisiae YAR014C BUD14 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; protein phosphatase regulator BUD14 391875 2892171 KLLA0_C04257g Kluyveromyces lactis protein phosphatase regulator BUD14 XP_452387.1 389812 D 28985 CDS KLLA0_C04279g 2892192 392168..394822 C 1 NC_006039.1 similar to uniprot|P38217 Saccharomyces cerevisiae YBR017C KAP104 Transportin cytosolic karyopherin beta 2 involved in delivery of heterogeneous nuclear ribonucleoproteins to the nucleoplasm binds rg-nuclear localization signals on Nab2p and Hrp1p plays a role in cell-cycle progression; uncharacterized protein 394822 2892192 KLLA0_C04279g Kluyveromyces lactis uncharacterized protein XP_452388.1 392168 D 28985 CDS KLLA0_C04301g 2892271 395294..396892 C 1 NC_006039.1 similar to uniprot|P32375 Saccharomyces cerevisiae YIR027C DAL1 Allantoinase converts allantoin to allantoate in the first step of allantoin degradation expression sensitive to nitrogen catabolite repression; allantoinase 396892 2892271 KLLA0_C04301g Kluyveromyces lactis allantoinase XP_452389.1 395294 D 28985 CDS KLLA0_C04323g 2891899 complement(396979..397698) C 1 NC_006039.1 similar to uniprot|Q12403 Saccharomyces cerevisiae YDL018C; uncharacterized protein 397698 2891899 KLLA0_C04323g Kluyveromyces lactis uncharacterized protein XP_452390.1 396979 R 28985 CDS KLLA0_C04345g 2892051 397899..399326 C 1 NC_006039.1 similar to uniprot|P06243 Saccharomyces cerevisiae YDL017W CDC7 DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p kinase activity correlates with cyclical DBF4 expression; serine/threonine protein kinase CDC7 399326 2892051 KLLA0_C04345g Kluyveromyces lactis serine/threonine protein kinase CDC7 XP_452391.1 397899 D 28985 CDS KLLA0_C04367g 2892268 complement(399631..400590) C 1 NC_006039.1 similar to uniprot|Q99190 Saccharomyces cerevisiae YDL015C TSC13 ER protein involved in very long chain fatty acid synthesis; trans-2-enoyl-CoA reductase (NADPH) TSC13 400590 2892268 KLLA0_C04367g Kluyveromyces lactis trans-2-enoyl-CoA reductase (NADPH) TSC13 XP_452392.1 399631 R 28985 CDS KLLA0_C04389g 2892085 401421..402428 C 1 NC_006039.1 similar to uniprot|P15646 Saccharomyces cerevisiae YDL014W; rRNA methyltransferase NOP1 402428 2892085 KLLA0_C04389g Kluyveromyces lactis rRNA methyltransferase NOP1 XP_452393.1 401421 D 28985 CDS KLLA0_C04411g 2891908 403257..405080 C 1 NC_006039.1 similar to uniprot|P32828 Saccharomyces cerevisiae YDL013W HEX3 Ring finger protein involved in the DNA damage response with possible recombination role genetically identified by synthetic lethality with SGS1 (DNA helicase) and TOP3 (DNA topoisomerase) sporulation role interacts with Slx8p and Lin1p; SUMO-targeted ubiquitin ligase complex subunit SLX5 405080 2891908 KLLA0_C04411g Kluyveromyces lactis SUMO-targeted ubiquitin ligase complex subunit SLX5 XP_452394.1 403257 D 28985 CDS KLLA0_C04433g 2892082 405523..406626 C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 406626 2892082 KLLA0_C04433g Kluyveromyces lactis uncharacterized protein XP_452395.1 405523 D 28985 CDS KLLA0_C04455g 2891853 408090..409448 C 1 NC_006039.1 weakly similar to uniprot|P38277 Saccharomyces cerevisiae YBR138C Cytoplasmic protein of unknown function potentially phosphorylated by Cdc28p; uncharacterized protein 409448 2891853 KLLA0_C04455g Kluyveromyces lactis uncharacterized protein XP_452397.1 408090 D 28985 CDS KLLA0_C04477g 2892176 complement(409543..413304) C 1 NC_006039.1 similar to uniprot|Q08234 Saccharomyces cerevisiae YOL075C Hypothetical ORF; uncharacterized protein 413304 2892176 KLLA0_C04477g Kluyveromyces lactis uncharacterized protein XP_452398.1 409543 R 28985 CDS KLLA0_C04510g 2892189 413587..414180 C 1 NC_006039.1 similar to uniprot|P48363 Saccharomyces cerevisiae YGR078C PAC10 Part of the heteromeric co-chaperone GimC/prefoldin complex which promotes efficient protein folding; tubulin-binding prefolding complex subunit PAC10 414180 2892189 KLLA0_C04510g Kluyveromyces lactis tubulin-binding prefolding complex subunit PAC10 XP_452400.1 413587 D 28985 CDS KLLA0_C04532g 2892322 complement(414275..415111) C 1 NC_006039.1 weakly similar to uniprot|Q08232 Saccharomyces cerevisiae YOL073C Hypothetical ORF; uncharacterized protein 415111 2892322 KLLA0_C04532g Kluyveromyces lactis uncharacterized protein XP_452401.1 414275 R 28985 CDS KLLA0_C04554g 2892331 415462..417156 C 1 NC_006039.1 similar to uniprot|Q756P6 Ashbya gossypii AER208C AER208Cp and weakly similar to YGR077C uniprot|P53248 Saccharomyces cerevisiae YGR077C PEX8 Required for peroxisome assembly peroxisome associated protein containing a PTS1 signal; uncharacterized protein 417156 2892331 KLLA0_C04554g Kluyveromyces lactis uncharacterized protein XP_452402.1 415462 D 28985 CDS KLLA0_C04576g 2892335 complement(417217..419001) C 1 NC_006039.1 highly similar to uniprot|Q06218 Saccharomyces cerevisiae YLR276C DBP9 ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit; ATP-dependent DNA/RNA helicase 419001 2892335 KLLA0_C04576g Kluyveromyces lactis ATP-dependent DNA/RNA helicase XP_452403.1 417217 R 28985 CDS KLLA0_C04598g 2892326 complement(419591..421885) C 1 NC_006039.1 highly similar to uniprot|Q06224 Saccharomyces cerevisiae YLR277C YSH1 subunit of Polyadenylation factor I (PF I); cleavage polyadenylation factor subunit YSH1 421885 2892326 KLLA0_C04598g Kluyveromyces lactis cleavage polyadenylation factor subunit YSH1 XP_452404.1 419591 R 28985 CDS KLLA0_C04620g 2892337 complement(422705..426514) C 1 NC_006039.1 similar to uniprot|Q74ZB9 Ashbya gossypii AGR280C AGR280Cp and some similarites with YLR278C uniprot|Q05854 Saccharomyces cerevisiae YLR278C Protein of unknown function localizes to the nucleus potential Cdc28p substrate; uncharacterized protein 426514 2892337 KLLA0_C04620g Kluyveromyces lactis uncharacterized protein XP_452405.1 422705 R 28985 CDS KLLA0_C04642g 2892330 complement(427221..427727) C 1 NC_006039.1 similar to uniprot|Q05863 Saccharomyces cerevisiae YLR281C Hypothetical ORF; uncharacterized protein 427727 2892330 KLLA0_C04642g Kluyveromyces lactis uncharacterized protein XP_452406.1 427221 R 28985 CDS KLLA0_C04664g 2892316 427841..428791 C 1 NC_006039.1 similar to uniprot|Q05867 Saccharomyces cerevisiae YLR283W Hypothetical ORF; uncharacterized protein 428791 2892316 KLLA0_C04664g Kluyveromyces lactis uncharacterized protein XP_452407.1 427841 D 28985 CDS KLLA0_C04686g 2891907 complement(428962..429795) C 1 NC_006039.1 similar to uniprot|Q05871 Saccharomyces cerevisiae YLR284C ECI1 Peroxisomal delta3 delta2-enoyl-CoA isomerase hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl- CoA essential for the beta-oxidation of unsaturated fatty acids oleate-induced; dodecenoyl-CoA isomerase 429795 2891907 KLLA0_C04686g Kluyveromyces lactis dodecenoyl-CoA isomerase XP_452408.1 428962 R 28985 CDS KLLA0_C04708g 2892340 430441..431253 C 1 NC_006039.1 similar to uniprot|Q05874 Saccharomyces cerevisiae YLR285W NNT1 Putative nicotinamide N-methyltransferase has a role in rDNA silencing and in lifespan determination; S-adenosylmethionine-dependent methyltransferase 431253 2892340 KLLA0_C04708g Kluyveromyces lactis S-adenosylmethionine-dependent methyltransferase XP_452409.1 430441 D 28985 CDS KLLA0_C04730g 2891846 complement(431651..433306) C 1 NC_006039.1 similar to uniprot|P29029 Saccharomyces cerevisiae YLR286C CTS1 Endochitinase required for cell separation after mitosis transcriptional activation during late G and early M cell cycle phases is mediated by transcription factor Ace2p; chitinase 433306 2891846 KLLA0_C04730g Kluyveromyces lactis chitinase XP_452410.1 431651 R 28985 CDS KLLA0_C04752g 2891937 433528..433932 C 1 NC_006039.1 no similarity; uncharacterized protein 433932 2891937 KLLA0_C04752g Kluyveromyces lactis uncharacterized protein XP_452411.1 433528 D 28985 CDS KLLA0_C04774g 2892592 434720..436681 C 1 NC_006039.1 similar to uniprot|Q12446 Saccharomyces cerevisiae YOR181W LAS17 Actin assembly factor activates the Arp2/3 protein complex that nucleates branched actin filaments localizes with the Arp2/3 complex to actin patches homolog of the human Wiskott-Aldrich syndrome protein (WASP); actin-binding protein LAS17 436681 2892592 KLLA0_C04774g Kluyveromyces lactis actin-binding protein LAS17 XP_452412.1 434720 D 28985 CDS KLLA0_C04796g 2892338 complement(436807..437865) C 1 NC_006039.1 some similarities with uniprot|Q05881 Saccharomyces cerevisiae YLR287C Hypothetical ORF; uncharacterized protein 437865 2892338 KLLA0_C04796g Kluyveromyces lactis uncharacterized protein XP_452413.1 436807 R 28985 CDS KLLA0_C04809g 2892328 complement(join(438318..438506,439036..439038)) C 1 NC_006039.1 similar to uniprot|Q12087 Saccharomyces cerevisiae YOR182C RPS30B and similar to uniprot|Q12087 Saccharomyces cerevisiae YLR287C-A RPS30A; 40S ribosomal protein eS30 439038 2892328 KLLA0_C04809g Kluyveromyces lactis 40S ribosomal protein eS30 XP_452414.1 438318 R 28985 CDS KLLA0_C04818g 2892343 439585..440763 C 1 NC_006039.1 highly similar to uniprot|P33330 Saccharomyces cerevisiae YOR184W SER1 phosphoserine transaminase; O-phospho-L-serine:2-oxoglutarate transaminase 440763 2892343 KLLA0_C04818g Kluyveromyces lactis O-phospho-L-serine:2-oxoglutarate transaminase XP_452415.1 439585 D 28985 CDS KLLA0_C04840g 2892201 complement(440770..441930) C 1 NC_006039.1 similar to uniprot|Q02574 Saccharomyces cerevisiae YLR288C MEC3 Involved in checkpoint control and DNA repair forms a clamp with Rad17p and Ddc1p that is loaded onto partial duplex DNA DNA damage checkpoint protein; uncharacterized protein 441930 2892201 KLLA0_C04840g Kluyveromyces lactis uncharacterized protein XP_452416.1 440770 R 28985 CDS KLLA0_C04862g 2892318 442167..444062 C 1 NC_006039.1 highly similar to uniprot|P46943 Saccharomyces cerevisiae YLR289W GUF1 Mitochondrial GTPase of unknown function; GTPase GUF1 444062 2892318 KLLA0_C04862g Kluyveromyces lactis GTPase GUF1 XP_452417.1 442167 D 28985 CDS KLLA0_C04884g 2892333 444289..444951 C 1 NC_006039.1 similar to uniprot|P25362 Saccharomyces cerevisiae YCR020C PET18 Protein required for respiratory growth and stability of the mitochondrial genome; uncharacterized protein 444951 2892333 KLLA0_C04884g Kluyveromyces lactis uncharacterized protein XP_452418.1 444289 D 28985 CDS KLLA0_C04906g 2891817 complement(445437..447611) C 1 NC_006039.1 similar to uniprot|Q08908 Saccharomyces cerevisiae YOR384W; uncharacterized protein 447611 2891817 KLLA0_C04906g Kluyveromyces lactis uncharacterized protein XP_452419.1 445437 R 28985 CDS KLLA0_C04928g 2891985 449820..450344 C 1 NC_006039.1 some similarities with uniprot|Q08907 Saccharomyces cerevisiae YOR383C; uncharacterized protein 450344 2891985 KLLA0_C04928g Kluyveromyces lactis uncharacterized protein XP_452420.1 449820 D 28985 CDS KLLA0_C04950g 2891989 452463..452774 C 1 NC_006039.1 no similarity; uncharacterized protein 452774 2891989 KLLA0_C04950g Kluyveromyces lactis uncharacterized protein XP_452421.2 452463 D 28985 CDS KLLA0_C04994g 2891961 453438..455264 C 1 NC_006039.1 weakly similar to uniprot|Q04433 Saccharomyces cerevisiae YDR534c Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall; uncharacterized protein 455264 2891961 KLLA0_C04994g Kluyveromyces lactis uncharacterized protein XP_452423.1 453438 D 28985 CDS KLLA0_C05016g 2892213 complement(456048..456527) C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 456527 2892213 KLLA0_C05016g Kluyveromyces lactis uncharacterized protein XP_452424.1 456048 R 28985 CDS KLLA0_C05060g 2892488 458924..459601 C 1 NC_006039.1 weakly similar to uniprot|Q04734 Saccharomyces cerevisiae YMR063W; uncharacterized protein 459601 2892488 KLLA0_C05060g Kluyveromyces lactis uncharacterized protein XP_452426.1 458924 D 28985 CDS KLLA0_C05082g 2891981 complement(461375..462445) C 1 NC_006039.1 similar to uniprot|P32502 Saccharomyces cerevisiae YLR291C GCD7 Beta subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression; uncharacterized protein 462445 2891981 KLLA0_C05082g Kluyveromyces lactis uncharacterized protein XP_452427.1 461375 R 28985 CDS KLLA0_C05104g 2892369 complement(462684..463316) C 1 NC_006039.1 similar to uniprot|P39742 Saccharomyces cerevisiae YLR292C SEC72 Non-essential subunit of Sec63 complex (Sec63p Sec62p Sec66p and Sec72p) with Sec61 complex Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; Sec63 complex subunit SEC72 463316 2892369 KLLA0_C05104g Kluyveromyces lactis Sec63 complex subunit SEC72 XP_452428.1 462684 R 28985 CDS KLLA0_C05126g 2892303 complement(463657..464301) C 1 NC_006039.1 highly similar to uniprot|P32836 Saccharomyces cerevisiae YOR185C GSP2 GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization RNA processing and transport interacts with Kap121p Kap123p and Pdr6p (karyophilin betas) Gsp1p homolog that is not required for viability; uncharacterized protein 464301 2892303 KLLA0_C05126g Kluyveromyces lactis uncharacterized protein XP_452429.1 463657 R 28985 CDS KLLA0_C05148g 2892363 complement(464727..465506) C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 465506 2892363 KLLA0_C05148g Kluyveromyces lactis uncharacterized protein XP_452430.1 464727 R 28985 CDS KLLA0_C05170g 2892443 complement(465845..466174) C 1 NC_006039.1 similar to uniprot|Q12349 Saccharomyces cerevisiae YLR295C ATP14 Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis; uncharacterized protein 466174 2892443 KLLA0_C05170g Kluyveromyces lactis uncharacterized protein XP_452431.1 465845 R 28985 CDS KLLA0_C05192g 2892461 complement(466506..467075) C 1 NC_006039.1 weakly similar to uniprot|Q05900 Saccharomyces cerevisiae YLR298C YHC1 U1 snRNP protein required for pre-mRNA splicing; uncharacterized protein 467075 2892461 KLLA0_C05192g Kluyveromyces lactis uncharacterized protein XP_452432.1 466506 R 28985 CDS KLLA0_C05214g 2892357 467624..468916 C 1 NC_006039.1 highly similar to uniprot|P02992 Saccharomyces cerevisiae YOR187W TUF1 Mitochondrial translation elongation factor Tu comprises both GTPase and guanine nucleotide exchange factor activities while these activities are found in separate proteins in S. pombe and humans; translation elongation factor Tu 468916 2892357 KLLA0_C05214g Kluyveromyces lactis translation elongation factor Tu XP_452433.1 467624 D 28985 CDS KLLA0_C05236g 2892388 469306..471111 C 1 NC_006039.1 similar to uniprot|Q05902 Saccharomyces cerevisiae YLR299W ECM38 Gamma-glutamyltranspeptidase major glutathione-degrading enzyme expression induced mainly by nitrogen starvation; gamma-glutamyltransferase 471111 2892388 KLLA0_C05236g Kluyveromyces lactis gamma-glutamyltransferase XP_452434.1 469306 D 28985 CDS KLLA0_C05258g 2892455 471500..475567 C 1 NC_006039.1 some similarities with uniprot|P21339 Saccharomyces cerevisiae YOR188W MSB1 Protein involved in positive regulation of both 1 3-beta-glucan synthesis and the Pkc1p-MAPK pathway potential Cdc28p substrate multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42 and of mutations in BEM4; uncharacterized protein 475567 2892455 KLLA0_C05258g Kluyveromyces lactis uncharacterized protein XP_452435.1 471500 D 28985 CDS KLLA0_C05302g 2892510 476377..476808 C 1 NC_006039.1 no similarity; uncharacterized protein 476808 2892510 KLLA0_C05302g Kluyveromyces lactis uncharacterized protein XP_452436.1 476377 D 28985 CDS KLLA0_C05324g 2892517 478376..479665 C 1 NC_006039.1 uniprot|Q12628 Kluyveromyces lactis KLLA0C05324g Glucan 1 3-beta-glucosidase precursor; glucan 1,3-beta-glucosidase 479665 2892517 KLLA0_C05324g Kluyveromyces lactis glucan 1,3-beta-glucosidase XP_452437.1 478376 D 28985 CDS KLLA0_C05346g 2892379 480364..481104 C 1 NC_006039.1 weakly similar to uniprot|P43582 Saccharomyces cerevisiae YFL010C WWM1 WW domain containing protein interacting with Metacaspase (MCA1); uncharacterized protein 481104 2892379 KLLA0_C05346g Kluyveromyces lactis uncharacterized protein XP_452438.1 480364 D 28985 CDS KLLA0_C05368g 2892355 481598..486415 C 1 NC_006039.1 some similarities with uniprot|Q08562 Saccharomyces cerevisiae YOR191W RIS1 Member of the SWI/SNF family of DNA-dependent ATPases plays a role in antagonizing silencing during mating-type switching contains an N-terminal domain that interacts with Sir4p and a C-terminal SNF2 domain; translocase ULS1 486415 2892355 KLLA0_C05368g Kluyveromyces lactis translocase ULS1 XP_452439.1 481598 D 28985 CDS KLLA0_C05390g 2892451 486863..487588 C 1 NC_006039.1 similar to uniprot|Q05905 Saccharomyces cerevisiae YLR301W Hypothetical ORF; uncharacterized protein 487588 2892451 KLLA0_C05390g Kluyveromyces lactis uncharacterized protein XP_452440.1 486863 D 28985 CDS KLLA0_C05412g 2892505 487927..488601 C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 488601 2892505 KLLA0_C05412g Kluyveromyces lactis uncharacterized protein XP_452441.1 487927 D 28985 CDS KLLA0_C05456g 2892502 complement(489363..490034) C 1 NC_006039.1 no similarity; uncharacterized protein 490034 2892502 KLLA0_C05456g Kluyveromyces lactis uncharacterized protein XP_452442.1 489363 R 28985 CDS KLLA0_C05478g 2892499 490633..491040 C 1 NC_006039.1 highly similar to uniprot|P53173 Saccharomyces cerevisiae YGL054C ERV14 Protein localized to COPII-coated vesicles involved in vesicle formation and incorporation of specific secretory cargo required for the delivery of bud-site selection protein Axl2p to cell surface related to Drosophila cornichon; uncharacterized protein 491040 2892499 KLLA0_C05478g Kluyveromyces lactis uncharacterized protein XP_452443.1 490633 D 28985 CDS KLLA0_C05500g 2892623 complement(491305..492183) C 1 NC_006039.1 some similarities with uniprot|P38313 Saccharomyces cerevisiae YBR211C AME1 associated with microtubules and essential regulator of microtubule stability; uncharacterized protein 492183 2892623 KLLA0_C05500g Kluyveromyces lactis uncharacterized protein XP_452444.1 491305 R 28985 CDS KLLA0_C05522g 2892300 494240..495862 C 1 NC_006039.1 some similarities with uniprot|P32831 Saccharomyces cerevisiae YBR212W NGR1 negative growth regulatory protein; uncharacterized protein 495862 2892300 KLLA0_C05522g Kluyveromyces lactis uncharacterized protein XP_452445.1 494240 D 28985 CDS KLLA0_C05544g 2892146 496583..497374 C 1 NC_006039.1 similar to uniprot|P15807 Saccharomyces cerevisiae YBR213W MET8 Bifunctional dehydrogenase and ferrochelatase involved in the biosynthesis of siroheme also involved in the expression of PAPS reductase and sulfite reductase; bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8 497374 2892146 KLLA0_C05544g Kluyveromyces lactis bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8 XP_452446.1 496583 D 28985 CDS KLLA0_C05566g 2892035 complement(497877..499310) C 1 NC_006039.1 similar to uniprot|P21147 Saccharomyces cerevisiae YGL055W OLE1 Fatty acid desaturase required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria; stearoyl-CoA 9-desaturase 499310 2892035 KLLA0_C05566g Kluyveromyces lactis stearoyl-CoA 9-desaturase XP_452447.1 497877 R 28985 CDS KLLA0_C05588g 2892397 500622..502178 C 1 NC_006039.1 similar to uniprot|P53172 Saccharomyces cerevisiae YGL056C SDS23 Spindle pole body protein and similar to YBR214W uniprot|P38314 Saccharomyces cerevisiae YBR214W SDS24 Nuclear protein with similarity to S. pombe Sds23, suppresses dis2 mutations; uncharacterized protein 502178 2892397 KLLA0_C05588g Kluyveromyces lactis uncharacterized protein XP_452448.1 500622 D 28985 CDS KLLA0_C05610g 2892601 502744..503295 C 1 NC_006039.1 some similarities with uniprot|P53171 Saccharomyces cerevisiae YGL057C; uncharacterized protein 503295 2892601 KLLA0_C05610g Kluyveromyces lactis uncharacterized protein XP_452449.1 502744 D 28985 CDS KLLA0_C05632g 2892656 complement(503484..503978) C 1 NC_006039.1 highly similar to uniprot|P06104 Saccharomyces cerevisiae YGL058W RAD6 Ubiquitin-conjugating enzyme (E2) involved in postreplication repair (with Rad18p) sporulation telomere silencing and ubiquitin-mediated N-end rule protein degradation (with Ubr1p); E2 ubiquitin-conjugating protein RAD6 503978 2892656 KLLA0_C05632g Kluyveromyces lactis E2 ubiquitin-conjugating protein RAD6 XP_452450.1 503484 R 28985 CDS KLLA0_C05654g 2892383 complement(504568..505989) C 1 NC_006039.1 similar to uniprot|P53170 Saccharomyces cerevisiae YGL059W Hypothetical ORF; protein kinase PKP2 505989 2892383 KLLA0_C05654g Kluyveromyces lactis protein kinase PKP2 XP_452451.1 504568 R 28985 CDS KLLA0_C05676g 2892324 506539..508074 C 1 NC_006039.1 weakly similar to uniprot|Q01448 Saccharomyces cerevisiae YBR215W HPC2 Highly charged basic protein required for normal cell-cycle regulation of histone gene transcription mutants display strong synthetic defects with subunits of FACT a complex that allows RNA Pol II to elongate through nucleosomes; uncharacterized protein 508074 2892324 KLLA0_C05676g Kluyveromyces lactis uncharacterized protein XP_452452.1 506539 D 28985 CDS KLLA0_C05698g 2892447 complement(508204..510312) C 1 NC_006039.1 similar to uniprot|P38315 Saccharomyces cerevisiae YBR216C YBP1 and to uniprot|P53169 Saccharomyces cerevisiae YGL060W YBP2; uncharacterized protein 510312 2892447 KLLA0_C05698g Kluyveromyces lactis uncharacterized protein XP_452453.1 508204 R 28985 CDS KLLA0_C05720g 2892360 510735..511304 C 1 NC_006039.1 similar to uniprot|P38316 Saccharomyces cerevisiae YBR217W ATG12 Protein that becomes conjugated to Atg5p by the E1 enzyme Atg7p a step that is essential for autophagy; uncharacterized protein 511304 2892360 KLLA0_C05720g Kluyveromyces lactis uncharacterized protein XP_452454.1 510735 D 28985 CDS KLLA0_C05742g 2891887 511607..512233 C 1 NC_006039.1 similar to uniprot|Q75ED7 Ashbya gossypii AAR161W DUO1 DASH complex subunit DUO1 and weakly similar to YGL061C uniprot|P53168 Saccharomyces cerevisiae YGL061C DUO1 Essential mitotic spindle protein required to maintain spindle integrity and kinetochore function part of the multisubunit DASH complex which binds microtubules and is transferred to the kinetochore prior to mitosis; uncharacterized protein 512233 2891887 KLLA0_C05742g Kluyveromyces lactis uncharacterized protein XP_452455.1 511607 D 28985 CDS KLLA0_C05764g 2892373 complement(512470..515991) C 1 NC_006039.1 highly similar to uniprot|P11154 Saccharomyces cerevisiae YGL062W PYC1 and to YBR218C uniprot|P32327 Saccharomyces cerevisiae YBR218C PYC2 converts pyruvate to oxaloacetate pyruvate carboxylase; uncharacterized protein 515991 2892373 KLLA0_C05764g Kluyveromyces lactis uncharacterized protein XP_452456.1 512470 R 28985 CDS KLLA0_C05786g 2892467 complement(517346..517720) C 1 NC_006039.1 similar to uniprot|P38633 Saccharomyces cerevisiae YGL127C SOH1 Protein with sequence similarity to RNA polymerases; interacts with a DNA repair protein, Rad5p, in the two-hybrid system; may provide a link between recombination in direct repeats and transcription; mediator complex subunit SOH1 517720 2892467 KLLA0_C05786g Kluyveromyces lactis mediator complex subunit SOH1 XP_452457.1 517346 R 28985 CDS KLLA0_C05852g 2892512 518508..519956 C 1 NC_006039.1 weakly similar to uniprot|Q04712 Saccharomyces cerevisiae YML043C RRN11 rDNA transcription factor CF component which also contains Rrn6p and Rrn7p which is required for rDNA transcription by RNA polymerase I component of rDNA transcription factor; uncharacterized protein 519956 2892512 KLLA0_C05852g Kluyveromyces lactis uncharacterized protein XP_452458.1 518508 D 28985 CDS KLLA0_C05874g 2891865 complement(520079..521740) C 1 NC_006039.1 weakly similar to uniprot|Q08109 Saccharomyces cerevisiae YOL013C HRD1 Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins genetically linked to the unfolded protein response (UPR) regulated through association with Hrd3p contains an H2 ring finger; E3 ubiquitin-protein ligase HRD1 521740 2891865 KLLA0_C05874g Kluyveromyces lactis E3 ubiquitin-protein ligase HRD1 XP_452459.1 520079 R 28985 CDS KLLA0_C05896g 2892391 522074..522550 C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 522550 2892391 KLLA0_C05896g Kluyveromyces lactis uncharacterized protein XP_452460.1 522074 D 28985 CDS KLLA0_C05918g 2891943 complement(522995..523393) C 1 NC_006039.1 similar to uniprot|Q12692 Saccharomyces cerevisiae YOL012C HTZ1 Histone variant H2AZ exchanged for histone H2A in nucleosomes by the SWR1 complex involved in transcriptional regulation through prevention of the spread of silent heterochromatin; histone H2AZ 523393 2891943 KLLA0_C05918g Kluyveromyces lactis histone H2AZ XP_452461.1 522995 R 28985 CDS KLLA0_C05940g 2892361 524768..526690 C 1 NC_006039.1 uniprot|O59863 Kluyveromyces lactis KLLA0C05940g PLB Lysophospholipase precursor; lysophospholipase 526690 2892361 KLLA0_C05940g Kluyveromyces lactis lysophospholipase XP_452462.1 524768 D 28985 CDS KLLA0_C05962g 2892444 complement(527216..528316) C 1 NC_006039.1 similar to uniprot|P50105 Saccharomyces cerevisiae YMR005W TAF4 TFIID subunit (48 kDa) involved in RNA polymerase II transcription initiation potential Cdc28p substrate; uncharacterized protein 528316 2892444 KLLA0_C05962g Kluyveromyces lactis uncharacterized protein XP_452463.1 527216 R 28985 CDS KLLA0_C05984g 2892494 528906..530000 C 1 NC_006039.1 highly similar to uniprot|Q08096 Saccharomyces cerevisiae YOL010W RCL1 RNA terminal phosphate cyclase-like protein involved in rRNA processing at sites A0 A1 and A2 does not possess detectable RNA cyclase activity; rRNA-processing endoribonuclease 530000 2892494 KLLA0_C05984g Kluyveromyces lactis rRNA-processing endoribonuclease XP_452464.1 528906 D 28985 CDS KLLA0_C06006g 2892476 complement(530169..531707) C 1 NC_006039.1 similar to uniprot|P40959 Saccharomyces cerevisiae YMR004W MVP1 Protein required for sorting proteins to the vacuole overproduction of Mvp1p suppresses several dominant VPS1 mutations Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; uncharacterized protein 531707 2892476 KLLA0_C06006g Kluyveromyces lactis uncharacterized protein XP_452465.1 530169 R 28985 CDS KLLA0_C06028g 2892491 complement(532044..532961) C 1 NC_006039.1 similar to uniprot|Q92328 Saccharomyces cerevisiae YOL009C MDM12 Required for normal mitochondrial morphology and distribution Mdm12p is a mitochondrial outer membrane protein. An Mdm12p homolog exists in S. Pombe which confers a dominant negative phenotype when expressed in S. cerevisiae; ERMES complex subunit MDM12 532961 2892491 KLLA0_C06028g Kluyveromyces lactis ERMES complex subunit MDM12 XP_452466.1 532044 R 28985 CDS KLLA0_C06050g 2891948 533200..533817 C 1 NC_006039.1 similar to uniprot|Q08058 Saccharomyces cerevisiae YOL008W Hypothetical ORF; ubiquinone-binding protein COQ10 533817 2891948 KLLA0_C06050g Kluyveromyces lactis ubiquinone-binding protein COQ10 XP_452467.1 533200 D 28985 CDS KLLA0_C06072g 2892261 complement(534152..534913) C 1 NC_006039.1 similar to uniprot|Q03673 Saccharomyces cerevisiae YMR003W; uncharacterized protein 534913 2892261 KLLA0_C06072g Kluyveromyces lactis uncharacterized protein XP_452468.1 534152 R 28985 CDS KLLA0_C06094g 2891885 complement(535470..535919) C 1 NC_006039.1 similar to uniprot|Q03667 Saccharomyces cerevisiae YMR002W Hypothetical ORF; uncharacterized protein 535919 2891885 KLLA0_C06094g Kluyveromyces lactis uncharacterized protein XP_452469.1 535470 R 28985 CDS KLLA0_C06116g 2892647 complement(536524..538881) C 1 NC_006039.1 similar to uniprot|P04786 Saccharomyces cerevisiae YOL006C TOP1 topoisomerase I; DNA topoisomerase 1 538881 2892647 KLLA0_C06116g Kluyveromyces lactis DNA topoisomerase 1 XP_452470.1 536524 R 28985 CDS KLLA0_C06138g 2891996 540409..542535 C 1 NC_006039.1 similar to uniprot|P32562 Saccharomyces cerevisiae YMR001C; polo kinase CDC5 542535 2891996 KLLA0_C06138g Kluyveromyces lactis polo kinase CDC5 XP_452471.1 540409 D 28985 CDS KLLA0_C06160g 2892295 complement(543239..543604) C 1 NC_006039.1 highly similar to uniprot|P38902 Saccharomyces cerevisiae YOL005C; DNA-directed RNA polymerase II core subunit RPB11 543604 2892295 KLLA0_C06160g Kluyveromyces lactis DNA-directed RNA polymerase II core subunit RPB11 XP_452472.1 543239 R 28985 CDS KLLA0_C06182g 2892627 544281..548840 C 1 NC_006039.1 similar to uniprot|Q75CF0 Ashbya gossypii ACL004W ACL004Wp and weakly similar to YOL004W uniprot|P22579 Saccharomyces cerevisiae YOL004W SIN3 DNA binding protein involved in transcriptional regulation; transcriptional regulator SIN3 548840 2892627 KLLA0_C06182g Kluyveromyces lactis transcriptional regulator SIN3 XP_452473.1 544281 D 28985 CDS KLLA0_C06204g 2892046 complement(548912..550045) C 1 NC_006039.1 similar to uniprot|Q12006 Saccharomyces cerevisiae YOL003C DHHC- CRD protein; palmitoyltransferase PFA4 550045 2892046 KLLA0_C06204g Kluyveromyces lactis palmitoyltransferase PFA4 XP_452474.1 548912 R 28985 CDS KLLA0_C06226g 2892291 550683..552461 C 1 NC_006039.1 similar to uniprot|P32807 Saccharomyces cerevisiae YMR284W YKU70 Forms heterodimer with Yku80p known as Ku binds chromosome ends and is involved in maintaining normal telomere length and structure in addition to participating in the formation of silent chromatin at telomere-proximal genes; ATP-dependent DNA helicase YKU70 552461 2892291 KLLA0_C06226g Kluyveromyces lactis ATP-dependent DNA helicase YKU70 XP_452475.1 550683 D 28985 CDS KLLA0_C06248g 2892569 complement(552493..554043) C 1 NC_006039.1 similar to uniprot|Q03264 Saccharomyces cerevisiae YMR285C; RNA exonuclease 554043 2892569 KLLA0_C06248g Kluyveromyces lactis RNA exonuclease XP_452476.1 552493 R 28985 CDS KLLA0_C06270g 2892204 554658..554912 C 1 NC_006039.1 highly similar to uniprot|P20084 Saccharomyces cerevisiae YMR286W MRPL33 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein uL30m 554912 2892204 KLLA0_C06270g Kluyveromyces lactis mitochondrial 54S ribosomal protein uL30m XP_452477.1 554658 D 28985 CDS KLLA0_C06292g 2892305 complement(555112..555882) C 1 NC_006039.1 some similarities with uniprot|Q03208 Saccharomyces cerevisiae YML119W; uncharacterized protein 555882 2892305 KLLA0_C06292g Kluyveromyces lactis uncharacterized protein XP_452478.1 555112 R 28985 CDS KLLA0_C06314g 2892673 complement(556468..559419) C 1 NC_006039.1 similar to uniprot|P39112 Saccharomyces cerevisiae YMR287C MSU1 RNase component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs; exoribonuclease II 559419 2892673 KLLA0_C06314g Kluyveromyces lactis exoribonuclease II XP_452479.1 556468 R 28985 CDS KLLA0_C06336g 2892105 561371..562930 C 1 NC_006039.1 highly similar to uniprot|P32340 Saccharomyces cerevisiae YML120C NDI1 NADH:ubiquinone oxidoreductase transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons in contrast to the higher eukaryotic multisubunit respiratory complex I which is absent in S. cerevisiae; NADH-ubiquinone reductase (H(+)-translocating) NDI1 562930 2892105 KLLA0_C06336g Kluyveromyces lactis NADH-ubiquinone reductase (H(+)-translocating) NDI1 XP_452480.1 561371 D 28985 CDS KLLA0_C06358g 2891977 complement(563583..564482) C 1 NC_006039.1 highly similar to uniprot|Q00582 Saccharomyces cerevisiae YML121W GTR1 Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle through its homolog and binding partner Gtr2p involved in phosphate transport and invasive growth human RagA and RagB proteins are functional homologs; Rag GTPase GTR1 564482 2891977 KLLA0_C06358g Kluyveromyces lactis Rag GTPase GTR1 XP_452481.1 563583 R 28985 CDS KLLA0_C06380g 2891837 564762..565322 C 1 NC_006039.1 similar to uniprot|P38876 Saccharomyces cerevisiae YHR189W PTH1 One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases dispensable for cell growth and for mitochondrial respiration; aminoacyl-tRNA hydrolase 565322 2891837 KLLA0_C06380g Kluyveromyces lactis aminoacyl-tRNA hydrolase XP_452482.1 564762 D 28985 CDS KLLA0_C06446g 2892624 complement(566371..567195) C 1 NC_006039.1 highly similar to uniprot|Q7LHP7 Saccharomyces cerevisiae YOR145C PNO1 Partner of Nob1 Protein required for cell viability; uncharacterized protein 567195 2892624 KLLA0_C06446g Kluyveromyces lactis uncharacterized protein XP_452484.1 566371 R 28985 CDS KLLA0_C06468g 2892562 567817..569568 C 1 NC_006039.1 similar to uniprot|Q12171 Saccharomyces cerevisiae YOR147W MDM32 Mitochondrial Distribution and Morphology; uncharacterized protein 569568 2892562 KLLA0_C06468g Kluyveromyces lactis uncharacterized protein XP_452485.1 567817 D 28985 CDS KLLA0_C06490g 2892634 complement(569789..570358) C 1 NC_006039.1 similar to uniprot|Q02521 Saccharomyces cerevisiae YOR148C SPP2 Required for final stages of splicesome maturation; promotes step 1 of splicing; spliceosome-associated protein; uncharacterized protein 570358 2892634 KLLA0_C06490g Kluyveromyces lactis uncharacterized protein XP_452486.1 569789 R 28985 CDS KLLA0_C06512g 2891905 570575..571810 C 1 NC_006039.1 similar to uniprot|Q04172 YDR393W Saccharomyces cerevisiae SHE9 Mitochondrial inner membrane protein required for normal mitochondrial morphology; uncharacterized protein 571810 2891905 KLLA0_C06512g Kluyveromyces lactis uncharacterized protein XP_452487.1 570575 D 28985 CDS KLLA0_C06534g 2892644 572219..573505 C 1 NC_006039.1 highly similar to uniprot|P33298 Saccharomyces cerevisiae YDR394W RPT3 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; proteasome regulatory particle base subunit RPT3 573505 2892644 KLLA0_C06534g Kluyveromyces lactis proteasome regulatory particle base subunit RPT3 XP_452488.1 572219 D 28985 CDS KLLA0_C06567g 2892567 complement(573595..575187) C 1 NC_006039.1 similar to uniprot|Q04174 Saccharomyces cerevisiae YOR149C SMP3 Protein involved in glycosyl phosphatidyl inositol synthesis most likely an alpha 1 2 mannosyltransferase utilized for addition of the fourth side-branching mannose onto the GPI core structure; glycosylphosphatidylinositol-alpha 1,2 mannosyltransferase 575187 2892567 KLLA0_C06567g Kluyveromyces lactis glycosylphosphatidylinositol-alpha 1,2 mannosyltransferase XP_452490.1 573595 R 28985 CDS KLLA0_C06589g 2892274 575605..578454 C 1 NC_006039.1 similar to uniprot|Q04175 Saccharomyces cerevisiae YDR395W SXM1 Nuclear protein; has similarity to Cse1p homologs including Nmd5p, Cse1p,Lph2p, and the human cellular apoptosis susceptibility protein, CAS1; also has similarity to the karyopherin Kap95p; uncharacterized protein 578454 2892274 KLLA0_C06589g Kluyveromyces lactis uncharacterized protein XP_452491.1 575605 D 28985 CDS KLLA0_C06611g 2892687 complement(578756..579217) C 1 NC_006039.1 similar to uniprot|Q04176 Saccharomyces cerevisiae YDR397C NCB2 Beta subunit of the NC2 dimeric histone-fold complex represses RNA polymerase II transcription through binding to TBP and inhibition of TFIIA and TFIIB homologous to the Dr1 subunit of the mammalian NC2 (negative cofactor2); negative cofactor 2 transcription regulator complex subunit NCB2 579217 2892687 KLLA0_C06611g Kluyveromyces lactis negative cofactor 2 transcription regulator complex subunit NCB2 XP_452492.1 578756 R 28985 CDS KLLA0_C06633g 2891882 580349..582244 C 1 NC_006039.1 similar to uniprot|Q04177 Saccharomyces cerevisiae YDR398W UTP5 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; uncharacterized protein 582244 2891882 KLLA0_C06633g Kluyveromyces lactis uncharacterized protein XP_452493.1 580349 D 28985 CDS KLLA0_C06655g 2891881 582949..583596 C 1 NC_006039.1 highly similar to uniprot|Q04178 Saccharomyces cerevisiae YDR399W HPT1 Dimeric hypoxanthine-guanine phosphoribosyltransferase catalyzes the formation of both inosine monophosphate and guanosine monophosphate mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome; hypoxanthine phosphoribosyltransferase 583596 2891881 KLLA0_C06655g Kluyveromyces lactis hypoxanthine phosphoribosyltransferase XP_452494.1 582949 D 28985 CDS KLLA0_C06677g 2892658 complement(583672..585093) C 1 NC_006039.1 similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport; uncharacterized protein 585093 2892658 KLLA0_C06677g Kluyveromyces lactis uncharacterized protein XP_452495.1 583672 R 28985 CDS KLLA0_C06699g 2892651 complement(586603..587634) C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 587634 2892651 KLLA0_C06699g Kluyveromyces lactis uncharacterized protein XP_452496.1 586603 R 28985 CDS KLLA0_C06721g 2892094 589402..590418 C 1 NC_006039.1 similar to uniprot|Q04179 YDR400W Saccharomyces cerevisiae URH1 uridine nucleosidase (uridine ribohydrolase); trifunctional uridine nucleosidase/nicotinamide riboside hydrolase/nicotinic acid riboside hydrolase 590418 2892094 KLLA0_C06721g Kluyveromyces lactis trifunctional uridine nucleosidase/nicotinamide riboside hydrolase/nicotinic acid riboside hydrolase XP_452497.1 589402 D 28985 CDS KLLA0_C06743g 2892641 complement(590585..592126) C 1 NC_006039.1 similar to uniprot|P21595 Saccharomyces cerevisiae YDR402C DIT2 Sporulation-specific enzyme required for spore wall maturation involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall homologous to cytochrome P-450s; uncharacterized protein 592126 2892641 KLLA0_C06743g Kluyveromyces lactis uncharacterized protein XP_452498.1 590585 R 28985 CDS KLLA0_C06765g 2892448 592993..594582 C 1 NC_006039.1 similar to uniprot|P21623 YDR403W Saccharomyces cerevisiae DIT1 Sporulation-specific enzyme required for spore wall maturation involved in the production of a soluble LL-dityrosine-containing precursor; uncharacterized protein 594582 2892448 KLLA0_C06765g Kluyveromyces lactis uncharacterized protein XP_452499.1 592993 D 28985 CDS KLLA0_C06787g 2891921 complement(595180..595695) C 1 NC_006039.1 highly similar to uniprot|P34087 Saccharomyces cerevisiae YDR404C RPB7 RNA polymerase II subunit B16 forms two subunit dissociable complex with Rpb4p; DNA-directed RNA polymerase II subunit RPB7 595695 2891921 KLLA0_C06787g Kluyveromyces lactis DNA-directed RNA polymerase II subunit RPB7 XP_452500.1 595180 R 28985 CDS KLLA0_C06809g 2891941 join(596252..596309,596442..596680) C 1 NC_006039.1 similar to uniprot|P19956 Saccharomyces cerevisiae YMR225C MRPL44 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein mL53 596680 2891941 KLLA0_C06809g Kluyveromyces lactis mitochondrial 54S ribosomal protein mL53 XP_452501.1 596252 D 28985 CDS KLLA0_C06842g 2891877 597029..598027 C 1 NC_006039.1 similar to uniprot|Q12481 Saccharomyces cerevisiae YOR287C Protein required for cell viability; rRNA-processing protein RRP36 598027 2891877 KLLA0_C06842g Kluyveromyces lactis rRNA-processing protein RRP36 XP_452503.1 597029 D 28985 CDS KLLA0_C06864g 2892066 complement(598412..598834) C 1 NC_006039.1 similar to uniprot|Q12305 Saccharomyces cerevisiae YOR285W Hypothetical ORF; uncharacterized protein 598834 2892066 KLLA0_C06864g Kluyveromyces lactis uncharacterized protein XP_452504.1 598412 R 28985 CDS KLLA0_C06886g 2892047 complement(599236..599709) C 1 NC_006039.1 similar to uniprot|Q12305 Saccharomyces cerevisiae YOR285W Hypothetical ORF; uncharacterized protein 599709 2892047 KLLA0_C06886g Kluyveromyces lactis uncharacterized protein XP_452505.1 599236 R 28985 CDS KLLA0_C06908g 2892028 complement(599885..600571) C 1 NC_006039.1 similar to uniprot|Q12040 Saccharomyces cerevisiae YOR283W Hypothetical ORF; phosphoglycerate mutase 600571 2892028 KLLA0_C06908g Kluyveromyces lactis phosphoglycerate mutase XP_452506.1 599885 R 28985 CDS KLLA0_C06930g 2892523 600876..602960 C 1 NC_006039.1 similar to uniprot|P32829 Saccharomyces cerevisiae YMR224C MRE11 Subunit of a complex with Rad50p and Xrs2p (RMX complex) that functions in repair of DNA double-strand breaks and in telomere stability exhibits nuclease activity that appears to be required for RMX function widely conserved; MRX complex nuclease subunit 602960 2892523 KLLA0_C06930g Kluyveromyces lactis MRX complex nuclease subunit XP_452507.1 600876 D 28985 CDS KLLA0_C06952g 2892282 603325..604182 C 1 NC_006039.1 similar to uniprot|Q12017 Saccharomyces cerevisiae YOR281C; uncharacterized protein 604182 2892282 KLLA0_C06952g Kluyveromyces lactis uncharacterized protein XP_452508.1 603325 D 28985 CDS KLLA0_C06974g 2891924 complement(604344..605684) C 1 NC_006039.1 similar to uniprot|P50102 Saccharomyces cerevisiae YMR223W UBP8 Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex required for SAGA-mediated deubiquitination of histone H2B; ubiquitin-specific protease UBP8 605684 2891924 KLLA0_C06974g Kluyveromyces lactis ubiquitin-specific protease UBP8 XP_452509.1 604344 R 28985 CDS KLLA0_C06996g 2892635 606430..607086 C 1 NC_006039.1 similar to uniprot|Q05015 Saccharomyces cerevisiae YMR222C FSH2 and similar to uniprot|Q99369 Saccharomyces cerevisiae YOR280C FSH3 Serine hydrolases; uncharacterized protein 607086 2892635 KLLA0_C06996g Kluyveromyces lactis uncharacterized protein XP_452510.1 606430 D 28985 CDS KLLA0_C07018g 2892604 607384..608169 C 1 NC_006039.1 similar to Saccharomyces cerevisiae and to YMR222C uniprot|Q05015 Saccharomyces cerevisiae FSH2 Serine hydrolase; uncharacterized protein 608169 2892604 KLLA0_C07018g Kluyveromyces lactis uncharacterized protein XP_452511.1 607384 D 28985 CDS KLLA0_C07040g 2892565 608643..610190 C 1 NC_006039.1 similar to uniprot|Q04991 Saccharomyces cerevisiae YMR221C FMP42 The authentic non-tagged protein was localized to the mitochondria; uncharacterized protein 610190 2892565 KLLA0_C07040g Kluyveromyces lactis uncharacterized protein XP_452512.1 608643 D 28985 CDS KLLA0_C07062g 2892576 610600..611568 C 1 NC_006039.1 weakly similar to uniprot|Q12192 Saccharomyces cerevisiae YOR279C RFM1 DNA-binding protein required for repression of middle sporulation genes specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; uncharacterized protein 611568 2892576 KLLA0_C07062g Kluyveromyces lactis uncharacterized protein XP_452513.1 610600 D 28985 CDS KLLA0_C07084g 2892044 complement(611642..612979) C 1 NC_006039.1 similar to uniprot|P24521 Saccharomyces cerevisiae YMR220W ERG8 Phosphomevalonate kinase an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols including ergosterol from mevalonate; phosphomevalonate kinase 612979 2892044 KLLA0_C07084g Kluyveromyces lactis phosphomevalonate kinase XP_452514.1 611642 R 28985 CDS KLLA0_C07106g 2892279 complement(613222..617508) C 1 NC_006039.1 weakly similar to uniprot|Q03661 Saccharomyces cerevisiae YMR219W ESC1 Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p; uncharacterized protein 617508 2892279 KLLA0_C07106g Kluyveromyces lactis uncharacterized protein XP_452515.1 613222 R 28985 CDS KLLA0_C07128g 2891975 617725..620925 C 1 NC_006039.1 similar to uniprot|Q756B5 Ashbya gossypii AER352C AER352Cp and weakly similar to YMR218C uniprot|Q03660 Saccharomyces cerevisiae YMR218C TRS130 Component of the targeting complex (TRAPP) involved in ER to Golgi membrane traffic; transport protein particle complex II subunit TRS130 620925 2891975 KLLA0_C07128g Kluyveromyces lactis transport protein particle complex II subunit TRS130 XP_452516.1 617725 D 28985 CDS KLLA0_C07150g 2892123 complement(620958..621740) C 1 NC_006039.1 similar to uniprot|P06174 Saccharomyces cerevisiae YOR278W HEM4 Uroporphyrinogen III synthase catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III the fourth step in the heme biosynthetic pathway; uroporphyrinogen-III synthase HEM4 621740 2892123 KLLA0_C07150g Kluyveromyces lactis uroporphyrinogen-III synthase HEM4 XP_452517.1 620958 R 28985 CDS KLLA0_C07172g 2892690 complement(622165..623739) C 1 NC_006039.1 highly similar to uniprot|P38625 Saccharomyces cerevisiae YMR217W GUA1 GMP synthase an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP) transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation; GMP synthase (glutamine-hydrolyzing) 623739 2892690 KLLA0_C07172g Kluyveromyces lactis GMP synthase (glutamine-hydrolyzing) XP_452518.1 622165 R 28985 CDS KLLA0_C07194g 2892553 624694..625587 C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 625587 2892553 KLLA0_C07194g Kluyveromyces lactis uncharacterized protein XP_452519.1 624694 D 28985 CDS KLLA0_C07216g 2891939 626227..628278 C 1 NC_006039.1 similar to uniprot|Q03656 Saccharomyces cerevisiae YMR216C; serine/threonine protein kinase SKY1 628278 2891939 KLLA0_C07216g Kluyveromyces lactis serine/threonine protein kinase SKY1 XP_452520.1 626227 D 28985 CDS KLLA0_C07238g 2891804 complement(630279..631778) C 1 NC_006039.1 similar to uniprot|Q03655 Saccharomyces cerevisiae YMR215W GAS3 Putative 1,3-beta-glucanosyltransferase has similarity to Gas1p localizes to the cell wall; uncharacterized protein 631778 2891804 KLLA0_C07238g Kluyveromyces lactis uncharacterized protein XP_452521.1 630279 R 28985 CDS KLLA0_C07260g 2892549 complement(632987..634093) C 1 NC_006039.1 similar to uniprot|P25303 Saccharomyces cerevisiae YMR214W SCJ1 dnaJ homolog; uncharacterized protein 634093 2892549 KLLA0_C07260g Kluyveromyces lactis uncharacterized protein XP_452522.1 632987 R 28985 CDS KLLA0_C07282g 2892209 complement(634695..635138) C 1 NC_006039.1 similar to uniprot|P12962 Saccharomyces cerevisiae YOR276W CAF20 Phosphoprotein of the mRNA cap-binding complex involved in translational control repressor of cap-dependent translation initiation competes with eIF4G for binding to eIF4E; uncharacterized protein 635138 2892209 KLLA0_C07282g Kluyveromyces lactis uncharacterized protein XP_452523.1 634695 R 28985 CDS KLLA0_C07304g 2892559 complement(635351..636982) C 1 NC_006039.1 similar to uniprot|Q03654 Saccharomyces cerevisiae YMR213W CEF1 Essential splicing factor associated with Prp19p and the spliceosome contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association evolutionarily conserved and homologous to S. pombe Cdc5p; uncharacterized protein 636982 2892559 KLLA0_C07304g Kluyveromyces lactis uncharacterized protein XP_452524.1 635351 R 28985 CDS KLLA0_C07326g 2892486 637629..639821 C 1 NC_006039.1 similar to uniprot|Q03653 Saccharomyces cerevisiae YMR212C EFR3 Non-essential protein of unknown function exhibits synthetic lethal genetic interactions with PHO85 green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; uncharacterized protein 639821 2892486 KLLA0_C07326g Kluyveromyces lactis uncharacterized protein XP_452525.1 637629 D 28985 CDS KLLA0_C07348g 2892561 639956..641914 C 1 NC_006039.1 similar to uniprot|Q12033 Saccharomyces cerevisiae YOR275C RIM20 Protein involved in proteolytic activation of Rim101p in response to alkaline pH member of the PalA/AIP1/Alix family interacts with the ESCRT-III subunits Snf7p suggesting a relationship between the response to pH and multivesicular body formation; uncharacterized protein 641914 2892561 KLLA0_C07348g Kluyveromyces lactis uncharacterized protein XP_452526.1 639956 D 28985 CDS KLLA0_C07359g 2892048 complement(641901..643196) C 1 NC_006039.1 similar to uniprot|P07884 Saccharomyces cerevisiae YOR274W MOD5 Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs gene is nuclear and encodes two isozymic forms; tRNA dimethylallyltransferase 643196 2892048 KLLA0_C07359g Kluyveromyces lactis tRNA dimethylallyltransferase XP_452527.1 641901 R 28985 CDS KLLA0_C07381g 2891914 complement(643441..644847) C 1 NC_006039.1 similar to uniprot|Q03652 Saccharomyces cerevisiae YMR211W; uncharacterized protein 644847 2891914 KLLA0_C07381g Kluyveromyces lactis uncharacterized protein XP_452528.1 643441 R 28985 CDS KLLA0_C07403g 2891833 646269..647555 C 1 NC_006039.1 similar to uniprot|Q03648 Saccharomyces cerevisiae YMR209C Hypothetical ORF; uncharacterized protein 647555 2891833 KLLA0_C07403g Kluyveromyces lactis uncharacterized protein XP_452529.1 646269 D 28985 CDS KLLA0_C07425g 2891805 complement(647673..649007) C 1 NC_006039.1 highly similar to uniprot|Q12024 Saccharomyces cerevisiae YOR272W YTM1 microtubule-associated protein; uncharacterized protein 649007 2891805 KLLA0_C07425g Kluyveromyces lactis uncharacterized protein XP_452530.1 647673 R 28985 CDS KLLA0_C07447g 2892412 650118..651101 C 1 NC_006039.1 highly similar to uniprot|Q12029 Saccharomyces cerevisiae YOR271C Hypothetical ORF; uncharacterized protein 651101 2892412 KLLA0_C07447g Kluyveromyces lactis uncharacterized protein XP_452531.1 650118 D 28985 CDS KLLA0_C07469g 2892302 complement(651446..652705) C 1 NC_006039.1 similar to uniprot|P07277 Saccharomyces cerevisiae YMR208W ERG12 Mevalonate kinase acts in the biosynthesis of isoprenoids and sterols including ergosterol from mevalonate; mevalonate kinase 652705 2892302 KLLA0_C07469g Kluyveromyces lactis mevalonate kinase XP_452532.1 651446 R 28985 CDS KLLA0_C07491g 2892421 653352..655841 C 1 NC_006039.1 similar to uniprot|P32563 Saccharomyces cerevisiae YOR270C VPH1 Subunit of vacuolar-ATPase V0 domain one of two isoforms (Vph1p and Stv1p) Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes; H(+)-transporting V0 sector ATPase subunit a 655841 2892421 KLLA0_C07491g Kluyveromyces lactis H(+)-transporting V0 sector ATPase subunit a XP_452533.1 653352 D 28985 CDS KLLA0_C07513g 2892206 complement(656060..657379) C 1 NC_006039.1 similar to uniprot|P39946 Saccharomyces cerevisiae YOR269W PAC1 Protein involved in nuclear migration part of the dynein/dynactin pathway targets dynein to microtubule tips which is necessary for sliding of microtubules along bud cortex synthetic lethal with bni1 homolog of human LIS1; uncharacterized protein 657379 2892206 KLLA0_C07513g Kluyveromyces lactis uncharacterized protein XP_452534.1 656060 R 28985 CDS KLLA0_C07535g 2892584 658746..660620 C 1 NC_006039.1 some similarities with uniprot|Q07224 Saccharomyces cerevisiae YOR267C HRK1 Protein kinase implicated in activation of the plasma membrane H()-ATPase Pma1p in response to glucose metabolism plays a role in ion homeostasis; uncharacterized protein 660620 2892584 KLLA0_C07535g Kluyveromyces lactis uncharacterized protein XP_452535.1 658746 D 28985 CDS KLLA0_C07557g 2891854 complement(661000..662187) C 1 NC_006039.1 similar to uniprot|P38969 Saccharomyces cerevisiae YOR266W PNT1 Involved in targeting of proteins to the mitochondrial inner membrane Pentamidine resistance protein involved in pentamidine resistance protein; uncharacterized protein 662187 2891854 KLLA0_C07557g Kluyveromyces lactis uncharacterized protein XP_452536.1 661000 R 28985 CDS KLLA0_C07579g 2892418 complement(662466..664325) C 1 NC_006039.1 similar to uniprot|P40053 Saccharomyces cerevisiae YER080W FMP29 The authentic non-tagged protein was localized to the mitochondria; uncharacterized protein 664325 2892418 KLLA0_C07579g Kluyveromyces lactis uncharacterized protein XP_452537.1 662466 R 28985 CDS KLLA0_C07601g 2892128 complement(665141..665833) C 1 NC_006039.1 weakly similar to uniprot|P40052 Saccharomyces cerevisiae YER079W Hypothetical ORF; uncharacterized protein 665833 2892128 KLLA0_C07601g Kluyveromyces lactis uncharacterized protein XP_452538.1 665141 R 28985 CDS KLLA0_C07623g 2892198 666694..668439 C 1 NC_006039.1 similar to uniprot|P20050 Saccharomyces cerevisiae YIL072W HOP1 Meiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex required for homologous chromosome synapsis and chiasma formation; uncharacterized protein 668439 2892198 KLLA0_C07623g Kluyveromyces lactis uncharacterized protein XP_452539.1 666694 D 28985 CDS KLLA0_C07645g 2892296 668726..670249 C 1 NC_006039.1 similar to uniprot|P40051 Saccharomyces cerevisiae YER078C Hypothetical ORF; aminopeptidase 670249 2892296 KLLA0_C07645g Kluyveromyces lactis aminopeptidase XP_452540.1 668726 D 28985 CDS KLLA0_C07667g 2892139 complement(670325..671494) C 1 NC_006039.1 some similarities with uniprot|P40512 Saccharomyces cerevisiae YIL071C PCI8 Possible shared subunit of Cop9 signalosome (CSN) and eIF3 binds eIF3b subunit Prt1p has possible dual functions in transcriptional and translational control contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain; uncharacterized protein 671494 2892139 KLLA0_C07667g Kluyveromyces lactis uncharacterized protein XP_452541.1 670325 R 28985 CDS KLLA0_C07689g 2891945 671623..673776 C 1 NC_006039.1 weakly similar to uniprot|P40050 Saccharomyces cerevisiae YER077C Hypothetical ORF; uncharacterized protein 673776 2891945 KLLA0_C07689g Kluyveromyces lactis uncharacterized protein XP_452542.1 671623 D 28985 CDS KLLA0_C07711g 2891906 complement(674146..674925) C 1 NC_006039.1 similar to uniprot|P40513 Saccharomyces cerevisiae YIL070C MAM33 Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation related to the human complement receptor gC1q-R; uncharacterized protein 674925 2891906 KLLA0_C07711g Kluyveromyces lactis uncharacterized protein XP_452543.1 674146 R 28985 CDS KLLA0_C07733g 2891831 676715..679666 C 1 NC_006039.1 similar to uniprot|P40048 Saccharomyces cerevisiae YER075C PTP3 Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing dephosporylates Hog1p MAPK and regulates its localization localized to the cytoplasm; tyrosine protein phosphatase PTP3 679666 2891831 KLLA0_C07733g Kluyveromyces lactis tyrosine protein phosphatase PTP3 XP_452544.1 676715 D 28985 CDS KLLA0_C07744g 9487422 complement(join(679857..679984,680200..680331,680413..680503)) C 1 NC_006039.1 highly similar to uniprot|Q3E834 Saccharomyces cerevisiae YER074W-A YOS1 Integral membrane protein required for ER to Golgi transport; uncharacterized protein 680503 9487422 KLLA0_C07744g Kluyveromyces lactis uncharacterized protein XP_002999358.1 679857 R 28985 CDS KLLA0_C07755g 2892298 complement(join(680963..681367,681941..681943)) C 1 NC_006039.1 highly similar to uniprot|P26782 Saccharomyces cerevisiae YIL069C RPS24B and highly similar to uniprot|P26782 Saccharomyces cerevisiae YER074W RPS24A proteins component of the small (40S) ribosomal subunit; 40S ribosomal protein eS24 681943 2892298 KLLA0_C07755g Kluyveromyces lactis 40S ribosomal protein eS24 XP_452545.1 680963 R 28985 CDS KLLA0_C07777g 2891931 complement(682962..684506) C 1 NC_006039.1 highly similar to uniprot|P40047 Saccharomyces cerevisiae YER073W ALD5 Mitochondrial aldehyde dehydrogenase that is activated by K and utilizes NADP as the preferred coenzyme; aldehyde dehydrogenase (NAD(P)(+)) ALD5 684506 2891931 KLLA0_C07777g Kluyveromyces lactis aldehyde dehydrogenase (NAD(P)(+)) ALD5 XP_452546.1 682962 R 28985 CDS KLLA0_C07799g 2892014 complement(686756..687145) C 1 NC_006039.1 highly similar to uniprot|P40046 Saccharomyces cerevisiae YER072W VTC1 Protein involved in vacuolar maintenance; uncharacterized protein 687145 2892014 KLLA0_C07799g Kluyveromyces lactis uncharacterized protein XP_452547.1 686756 R 28985 CDS KLLA0_C07821g 2892492 687809..688165 C 1 NC_006039.1 weakly similar to uniprot|P40045 Saccharomyces cerevisiae YER071C; uncharacterized protein 688165 2892492 KLLA0_C07821g Kluyveromyces lactis uncharacterized protein XP_452548.1 687809 D 28985 CDS KLLA0_C07843g 2891880 complement(688312..690696) C 1 NC_006039.1 similar to uniprot|P32844 Saccharomyces cerevisiae YIL068C SEC6 Essential 88kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis; SNARE-binding exocyst subunit SEC6 690696 2891880 KLLA0_C07843g Kluyveromyces lactis SNARE-binding exocyst subunit SEC6 XP_452549.1 688312 R 28985 CDS KLLA0_C07865g 2892395 complement(690987..692966) C 1 NC_006039.1 similar to uniprot|P40514 Saccharomyces cerevisiae YIL067C Hypothetical ORF; uncharacterized protein 692966 2892395 KLLA0_C07865g Kluyveromyces lactis uncharacterized protein XP_452550.1 690987 R 28985 CDS KLLA0_C07887g 2892088 complement(693437..696064) C 1 NC_006039.1 highly similar to uniprot|P21524 Saccharomyces cerevisiae YER070W RNR1 Ribonucleotide-diphosphate reductase (RNR) and to YIL066C uniprot|P21672 Saccharomyces cerevisiae YIL066C RNR3 Ribonucleotide- diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; ribonucleotide-diphosphate reductase subunit RNR3 696064 2892088 KLLA0_C07887g Kluyveromyces lactis ribonucleotide-diphosphate reductase subunit RNR3 XP_452551.1 693437 R 28985 CDS KLLA0_C07909g 2892080 complement(697288..697755) C 1 NC_006039.1 similar to uniprot|P40515 Saccharomyces cerevisiae YIL065C FIS1 Mitochondrial outer membrane protein involved in membrane fission required for localization of Dnm1p and Mdv1p during mitochondrial division; uncharacterized protein 697755 2892080 KLLA0_C07909g Kluyveromyces lactis uncharacterized protein XP_452552.1 697288 R 28985 CDS KLLA0_C07931g 2892054 698086..698784 C 1 NC_006039.1 similar to uniprot|P40516 Saccharomyces cerevisiae YIL064W Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; uncharacterized protein 698784 2892054 KLLA0_C07931g Kluyveromyces lactis uncharacterized protein XP_452553.1 698086 D 28985 CDS KLLA0_C07953g 2892003 complement(698867..699907) C 1 NC_006039.1 some similarities with uniprot|P40517 Saccharomyces cerevisiae YIL063C YRB2 Ran-GTPase-binding protein involved in nuclear export nuclear protein interacts with Gsp1p and Crm1p; uncharacterized protein 699907 2892003 KLLA0_C07953g Kluyveromyces lactis uncharacterized protein XP_452554.1 698867 R 28985 CDS KLLA0_C07975g 2892161 complement(700213..700674) C 1 NC_006039.1 similar to uniprot|P40518 Saccharomyces cerevisiae YIL062C ARC15 Subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches; uncharacterized protein 700674 2892161 KLLA0_C07975g Kluyveromyces lactis uncharacterized protein XP_452555.1 700213 R 28985 CDS KLLA0_C07997g 2892056 complement(701021..703591) C 1 NC_006039.1 highly similar to uniprot|Q01217 Saccharomyces cerevisiae YER069W ARG5 6 Bifunctional enzyme with acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase activities catalyzes the second and third steps in the biosynthesis of the arginine precursor ornithine forms a complex with Arg2p; bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase 703591 2892056 KLLA0_C07997g Kluyveromyces lactis bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase XP_452556.1 701021 R 28985 CDS KLLA0_C08019g 2892112 complement(704199..705104) C 1 NC_006039.1 weakly similar to uniprot|Q00916 Saccharomyces cerevisiae YIL061C SNP1 U1snRNP 70K protein homolog; U1 snRNP complex subunit SNP1 705104 2892112 KLLA0_C08019g Kluyveromyces lactis U1 snRNP complex subunit SNP1 XP_452557.1 704199 R 28985 CDS KLLA0_C08041g 2892194 complement(705516..707240) C 1 NC_006039.1 similar to uniprot|P34909 Saccharomyces cerevisiae YER068W MOT2 Component of the CCR4-NOT transcription regulatory complex which represses transcription at least in part by inhibiting functional TBP-DNA interactions and also aids in transcription elongation interacts with C-terminal region of Not1p; CCR4-NOT core ubiquitin-protein ligase subunit MOT2 707240 2892194 KLLA0_C08041g Kluyveromyces lactis CCR4-NOT core ubiquitin-protein ligase subunit MOT2 XP_452558.1 705516 R 28985 CDS KLLA0_C08063g 2892131 complement(707966..708457) C 1 NC_006039.1 highly similar to uniprot|P40188 Saccharomyces cerevisiae YIL057C Hypothetical ORF; uncharacterized protein 708457 2892131 KLLA0_C08063g Kluyveromyces lactis uncharacterized protein XP_452559.1 707966 R 28985 CDS KLLA0_C08107g 2892560 710617..712245 C 1 NC_006039.1 highly similar to uniprot|P28240 Saccharomyces cerevisiae YER065C ICL1 Isocitrate lyase catalyzes the formation of succinate and glyoxylate from isocitrate a key reaction of the glyoxylate cycle expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose; isocitrate lyase 1 712245 2892560 KLLA0_C08107g Kluyveromyces lactis isocitrate lyase 1 XP_452560.1 710617 D 28985 CDS KLLA0_C08151g 2892174 714910..716832 C 1 NC_006039.1 weakly similar to uniprot|P40522 Saccharomyces cerevisiae YIL056W Hypothetical ORF and to uniprot|P40041 Saccharomyces cerevisiae YER064C Non-essential nuclear protein; null mutation has global effects on transcription; uncharacterized protein 716832 2892174 KLLA0_C08151g Kluyveromyces lactis uncharacterized protein XP_452562.1 714910 D 28985 CDS KLLA0_C08173g 2892464 complement(717235..718728) C 1 NC_006039.1 some similarities with uniprot|P40523 Saccharomyces cerevisiae YIL055C Hypothetical ORF; uncharacterized protein 718728 2892464 KLLA0_C08173g Kluyveromyces lactis uncharacterized protein XP_452563.1 717235 R 28985 CDS KLLA0_C08195g 2891903 complement(719857..720588) C 1 NC_006039.1 weakly similar to uniprot|P40040 Saccharomyces cerevisiae YER063W THO1 Suppressor of the Transcriptional (T) defect of Hpr1 (H) by Overexpression (O) (putative) involved in transcription; uncharacterized protein 720588 2891903 KLLA0_C08195g Kluyveromyces lactis uncharacterized protein XP_452564.1 719857 R 28985 CDS KLLA0_C08217g 2892181 721753..722523 C 1 NC_006039.1 highly similar to uniprot|P41277 Saccharomyces cerevisiae RHR2 and to YER062C uniprot|P40106 Saccharomyces cerevisiae HOR2, two redundant DL-glycerol-3-phosphatases; uncharacterized protein 722523 2892181 KLLA0_C08217g Kluyveromyces lactis uncharacterized protein XP_452565.1 721753 D 28985 CDS KLLA0_C08239g 2892681 723077..724366 C 1 NC_006039.1 similar to uniprot|P39525 Saccharomyces cerevisiae YER061C CEM1 homology with beta-keto-acyl synthases Protein homologous to beta-keto-acyl synthase; fatty acid synthase CEM1 724366 2892681 KLLA0_C08239g Kluyveromyces lactis fatty acid synthase CEM1 XP_452566.1 723077 D 28985 CDS KLLA0_C08261g 2892001 complement(724399..725100) C 1 NC_006039.1 similar to uniprot|P40526 Saccharomyces cerevisiae YIL049W DFG10 Protein of unknown function involved in filamentous growth; uncharacterized protein 725100 2892001 KLLA0_C08261g Kluyveromyces lactis uncharacterized protein XP_452567.1 724399 R 28985 CDS KLLA0_C08283g 2891962 complement(725563..727122) C 1 NC_006039.1 similar to uniprot|P17064 Saccharomyces cerevisiae YER056C FCY2 and similar to uniprot|P40039 Saccharomyces cerevisiae YER060W FCY21 and similar to uniprot|Q12119 Saccharomyces cerevisiae YER060W-A FCY22, Purine-cytosine permeases; uncharacterized protein 727122 2891962 KLLA0_C08283g Kluyveromyces lactis uncharacterized protein XP_452568.1 725563 R 28985 CDS KLLA0_C08305g 2892571 complement(728996..730225) C 1 NC_006039.1 similar to uniprot|P40186 Saccharomyces cerevisiae YIL050W PCL7 Pho85p cyclin of the Pho80p subfamily forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p involved in glycogen metabolism expression is cell-cycle regulated and weakly similar to YER059W uniprot|P40038 Saccharomyces cerevisiae YER059W PCL6 Pho85p cyclin of the Pho80p subfamily forms the major Glc8p kinase together with Pcl7p and Pho85p involved in the control of glycogen storage by Pho85p stabilized by Elongin C binding; uncharacterized protein 730225 2892571 KLLA0_C08305g Kluyveromyces lactis uncharacterized protein XP_452569.1 728996 R 28985 CDS KLLA0_C08327g 2892049 complement(730884..731195) C 1 NC_006039.1 similar to uniprot|Q02771 Saccharomyces cerevisiae YER058W PET117 Protein required for assembly of cytochrome c oxidase; uncharacterized protein 731195 2892049 KLLA0_C08327g Kluyveromyces lactis uncharacterized protein XP_452570.1 730884 R 28985 CDS KLLA0_C08349g 2892186 731629..732051 C 1 NC_006039.1 similar to uniprot|P40185 Saccharomyces cerevisiae YIL051C MMF1 Mitochondrial protein involved in maintenance of the mitochondrial genome and similar to YER057C uniprot|P40037 Saccharomyces cerevisiae YER057C HMF1 Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high- dosage growth inhibitor; forms a homotrimer in vitro; uncharacterized protein 732051 2892186 KLLA0_C08349g Kluyveromyces lactis uncharacterized protein XP_452571.1 731629 D 28985 CDS KLLA0_C08371g 2892551 join(732878..732914,733482..733822) C 1 NC_006039.1 highly similar to uniprot|P40525 Saccharomyces cerevisiae YIL052C RPL34B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein; 60S ribosomal protein eL34 733822 2892551 KLLA0_C08371g Kluyveromyces lactis 60S ribosomal protein eL34 XP_452572.1 732878 D 28985 CDS KLLA0_C08393g 2892145 734655..738101 C 1 NC_006039.1 highly similar to uniprot|P40527 Saccharomyces cerevisiae YIL048W NEO1 Protein involved in the retrograde transport from the Golgi complex to the ER and the endosomal membrane traffic putative aminophospholipid translocase member of the highly conserved Drs2 family of P-type ATPases; uncharacterized protein 738101 2892145 KLLA0_C08393g Kluyveromyces lactis uncharacterized protein XP_452573.1 734655 D 28985 CDS KLLA0_C08415g 2891843 complement(738306..739271) C 1 NC_006039.1 highly similar to uniprot|P50278 Saccharomyces cerevisiae YNR034W; uncharacterized protein 739271 2891843 KLLA0_C08415g Kluyveromyces lactis uncharacterized protein XP_452574.1 738306 R 28985 CDS KLLA0_C08437g 2892017 739541..739984 C 1 NC_006039.1 no similarity; uncharacterized protein 739984 2892017 KLLA0_C08437g Kluyveromyces lactis uncharacterized protein XP_452575.1 739541 D 28985 CDS KLLA0_C08448g 2891819 complement(739952..742228) C 1 NC_006039.1 similar to uniprot|P37254 Saccharomyces cerevisiae YNR033W; 4-amino-4-deoxychorismate synthase 742228 2891819 KLLA0_C08448g Kluyveromyces lactis 4-amino-4-deoxychorismate synthase XP_452576.1 739952 R 28985 CDS KLLA0_C08470g 2892667 742530..742754 C 1 NC_006039.1 highly similar to uniprot|Q6Q546 Saccharomyces cerevisiae YNR032C-A HUB1 Ubiquitin-like protein modifier; ubiquitin-like protein HUB1 742754 2892667 KLLA0_C08470g Kluyveromyces lactis ubiquitin-like protein HUB1 XP_452578.1 742530 D 28985 CDS KLLA0_C08503g 2892664 complement(742889..743923) C 1 NC_006039.1 similar to uniprot|P32838 Saccharomyces cerevisiae YNR032W PPG1 Putative serine/threonine protein phosphatase required for glycogen accumulation interacts with Tap42p which binds to and regulates other protein phosphatases; uncharacterized protein 743923 2892664 KLLA0_C08503g Kluyveromyces lactis uncharacterized protein XP_452579.1 742889 R 28985 CDS KLLA0_C08525g 2892671 744554..749209 C 1 NC_006039.1 similar to uniprot|P53599 Saccharomyces cerevisiae YNR031C SSK2 Suppressor of Sensor Kinase (SLN1) A MAP kinase kinase kinase activator of Pbs2p; mitogen-activated protein kinase kinase kinase SSK2 749209 2892671 KLLA0_C08525g Kluyveromyces lactis mitogen-activated protein kinase kinase kinase SSK2 XP_452580.1 744554 D 28985 CDS KLLA0_C08547g 2892662 749737..751284 C 1 NC_006039.1 highly similar to uniprot|P25382 Saccharomyces cerevisiae YCR072C Protein required for cell viability; uncharacterized protein 751284 2892662 KLLA0_C08547g Kluyveromyces lactis uncharacterized protein XP_452581.1 749737 D 28985 CDS KLLA0_C08569g 2892297 751571..752104 C 1 NC_006039.1 similar to uniprot|P25642 Saccharomyces cerevisiae YCR071C IMG2 Mitochondrial ribosomal protein of the small subunit; mitochondrial 54S ribosomal protein mL49 752104 2892297 KLLA0_C08569g Kluyveromyces lactis mitochondrial 54S ribosomal protein mL49 XP_452582.1 751571 D 28985 CDS KLLA0_C08591g 2892071 complement(752256..753881) C 1 NC_006039.1 similar to uniprot|P53730 Saccharomyces cerevisiae YNR030W ECM39 Alpha-1 6-mannosyltransferase localized to the ER responsible for the addition of the alpha-1 6 mannose to dolichol-linked Man7GlcNAc2 acts in the dolichol pathway for N-glycosylation; dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase 753881 2892071 KLLA0_C08591g Kluyveromyces lactis dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase XP_452583.1 752256 R 28985 CDS KLLA0_C08613g 2892149 754098..755366 C 1 NC_006039.1 similar to uniprot|P53729 Saccharomyces cerevisiae YNR029C Hypothetical ORF; GTP-dependent zinc transferase 755366 2892149 KLLA0_C08613g Kluyveromyces lactis GTP-dependent zinc transferase XP_452584.1 754098 D 28985 CDS KLLA0_C08635g 2891859 complement(755556..756476) C 1 NC_006039.1 similar to gnl|GLV|DEHA0G11220g Debaryomyces hansenii DEHA0G11220g and weakly similar to YCR069W uniprot|P25334 Saccharomyces cerevisiae YCR069W CPR4 Peptidyl- prolyl cis-trans isomerase (cyclophilin) catalyzes the cis- trans isomerization of peptide bonds N-terminal to proline residues has a potential role in the secretory pathway; uncharacterized protein 756476 2891859 KLLA0_C08635g Kluyveromyces lactis uncharacterized protein XP_452585.1 755556 R 28985 CDS KLLA0_C08657g 2892236 757100..759268 C 1 NC_006039.1 some similarities with YDR520c; uncharacterized protein 759268 2892236 KLLA0_C08657g Kluyveromyces lactis uncharacterized protein XP_452586.1 757100 D 28985 CDS KLLA0_C08679g 2892241 complement(759288..760883) C 1 NC_006039.1 similar to uniprot|P25641 Saccharomyces cerevisiae YCR068W ATG15 Lipase required for intravacuolar lysis of autophagic bodies located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway; triglyceride lipase ATG15 760883 2892241 KLLA0_C08679g Kluyveromyces lactis triglyceride lipase ATG15 XP_452587.1 759288 R 28985 CDS KLLA0_C08701g 2892235 complement(761257..762171) C 1 NC_006039.1 similar to uniprot|P53727 Saccharomyces cerevisiae YNR027W BUD17 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; uncharacterized protein 762171 2892235 KLLA0_C08701g Kluyveromyces lactis uncharacterized protein XP_452588.1 761257 R 28985 CDS KLLA0_C08723g 2892239 762625..765501 C 1 NC_006039.1 similar to uniprot|P11655 Saccharomyces cerevisiae YNR026C SEC12 Guanine nucleotide exchange factor (GEF) glycosylated integral membrane protein of the endoplasmic reticulum important for the initiation of transport vesicle budding from the endoplasmic reticulum through activation of the GTPase Sar1p; GTPase-activating protein SED4 765501 2892239 KLLA0_C08723g Kluyveromyces lactis GTPase-activating protein SED4 XP_452589.1 762625 D 28985 CDS KLLA0_C08756g 2891860 complement(765847..767130) C 1 NC_006039.1 similar to uniprot|Q75EN0 Ashbya gossypii AAR049C RAD18 Postreplication repair ubiquitin-protein ligase E3 RAD18 and weakly similar to YCR066W uniprot|P10862 Saccharomyces cerevisiae YCR066W RAD18 Protein involved in postreplication repair binds single-stranded DNA and has single-stranded DNA dependent ATPase activity forms heterodimer with Rad6p contains RING-finger motif; E3 ubiquitin-protein ligase RAD18 767130 2891860 KLLA0_C08756g Kluyveromyces lactis E3 ubiquitin-protein ligase RAD18 XP_452591.1 765847 R 28985 CDS KLLA0_C08778g 2892572 complement(767642..769303) C 1 NC_006039.1 weakly similar to uniprot|P25364 Saccharomyces cerevisiae YCR065W HCM1 Forkhead transcription factor involved in cell cycle specific transcription of SPC110 encoding a spindle pole body (SPB) calmodulin binding protein dosage-dependent suppressor of calmodulin mutants with specific defects in SPB assembly; uncharacterized protein 769303 2892572 KLLA0_C08778g Kluyveromyces lactis uncharacterized protein XP_452592.1 767642 R 28985 CDS KLLA0_C08800g 2892457 complement(770303..770776) C 1 NC_006039.1 highly similar to uniprot|P25337 Saccharomyces cerevisiae YCR063W BUD31 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; U2 snRNP complex subunit BUD31 770776 2892457 KLLA0_C08800g Kluyveromyces lactis U2 snRNP complex subunit BUD31 XP_452593.1 770303 R 28985 CDS KLLA0_C08866g 2891810 complement(771719..773653) C 1 NC_006039.1 similar to uniprot|P25639 Saccharomyces cerevisiae YCR061W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; uncharacterized protein 773653 2891810 KLLA0_C08866g Kluyveromyces lactis uncharacterized protein XP_452594.1 771719 R 28985 CDS KLLA0_C08888g 2892501 776287..781614 C 1 NC_006039.1 similar to uniprot|P40989 Saccharomyces cerevisiae YGR032W GSC2 or uniprot|P38631 Saccharomyces cerevisiae YLR342W FKS1 or uniprot|Q04952 Saccharomyces cerevisiae YMR306W FKS3; uncharacterized protein 781614 2892501 KLLA0_C08888g Kluyveromyces lactis uncharacterized protein XP_452595.1 776287 D 28985 CDS KLLA0_C08910g 2892495 complement(781726..782073) C 1 NC_006039.1 similar to uniprot|P25638 Saccharomyces cerevisiae YCR060W TAH1 HSP90 cofactor interacts with Hsp82p Pih1p Rvb1 and Rvb2 contains a single TPR domain with at least two TPR motifs; uncharacterized protein 782073 2892495 KLLA0_C08910g Kluyveromyces lactis uncharacterized protein XP_452596.1 781726 R 28985 CDS KLLA0_C08932g 2892686 782424..783239 C 1 NC_006039.1 similar to uniprot|P25637 Saccharomyces cerevisiae YCR059C YIH1 piecemeal microautophagy of the nucleus (PMN); uncharacterized protein 783239 2892686 KLLA0_C08932g Kluyveromyces lactis uncharacterized protein XP_452597.1 782424 D 28985 CDS KLLA0_C08954g 2892675 complement(783356..783883) C 1 NC_006039.1 similar to uniprot|Q75EM3 Ashbya gossypii AAR056C AAR056Cp and weakly similar to YNR024w; uncharacterized protein 783883 2892675 KLLA0_C08954g Kluyveromyces lactis uncharacterized protein XP_452598.1 783356 R 28985 CDS KLLA0_C08976g 2892246 784536..787271 C 1 NC_006039.1 highly similar to uniprot|P25636 Saccharomyces cerevisiae YCR057C PWP2 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) Eight WD-repeats with homology with G protein beta subunits flanked by nonhomologous N-terminal and C-terminal extensions regulatory protein; snoRNA-binding rRNA-processing protein PWP2 787271 2892246 KLLA0_C08976g Kluyveromyces lactis snoRNA-binding rRNA-processing protein PWP2 XP_452599.1 784536 D 28985 CDS KLLA0_C08998g 2892320 787601..789214 C 1 NC_006039.1 weakly similar to uniprot|P25355 Saccharomyces cerevisiae YCR054C CTR86 Essential protein of unknown function; uncharacterized protein 789214 2892320 KLLA0_C08998g Kluyveromyces lactis uncharacterized protein XP_452600.1 787601 D 28985 CDS KLLA0_C09020g 2892244 complement(789284..790816) C 1 NC_006039.1 highly similar to uniprot|P16120 Saccharomyces cerevisiae YCR053W THR4 threonine synthase; threonine synthase THR4 790816 2892244 KLLA0_C09020g Kluyveromyces lactis threonine synthase THR4 XP_452601.1 789284 R 28985 CDS KLLA0_C09042g 2892208 complement(791144..792529) C 1 NC_006039.1 similar to uniprot|P53628 Saccharomyces cerevisiae YNR023W SNF12 73 kDa subunit of the SWI/SNF transcription activation complex homolog of Rsc6p subunit of the RSC chromatin remodeling complex; uncharacterized protein 792529 2892208 KLLA0_C09042g Kluyveromyces lactis uncharacterized protein XP_452602.1 791144 R 28985 CDS KLLA0_C09064g 2891864 793079..793483 C 1 NC_006039.1 similar to uniprot|P53724 Saccharomyces cerevisiae YNR022C MRPL50 Mitochondrial ribosomal protein of the large subunit not essential for mitochondrial translation; uncharacterized protein 793483 2891864 KLLA0_C09064g Kluyveromyces lactis uncharacterized protein XP_452603.1 793079 D 28985 CDS KLLA0_C09086g 2892256 complement(793869..795095) C 1 NC_006039.1 similar to uniprot|P53723 Saccharomyces cerevisiae YNR021W Hypothetical ORF; uncharacterized protein 795095 2892256 KLLA0_C09086g Kluyveromyces lactis uncharacterized protein XP_452604.1 793869 R 28985 CDS KLLA0_C09108g 2891822 complement(795433..796059) C 1 NC_006039.1 similar to uniprot|P25631 Saccharomyces cerevisiae YCR051W Hypothetical ORF; uncharacterized protein 796059 2891822 KLLA0_C09108g Kluyveromyces lactis uncharacterized protein XP_452605.1 795433 R 28985 CDS KLLA0_C09130g 2892006 796544..797287 C 1 NC_006039.1 similar to uniprot|P53722 Saccharomyces cerevisiae YNR020C Hypothetical ORF; uncharacterized protein 797287 2892006 KLLA0_C09130g Kluyveromyces lactis uncharacterized protein XP_452606.1 796544 D 28985 CDS KLLA0_C09152g 2892270 complement(797422..799209) C 1 NC_006039.1 similar to uniprot|P53629 Saccharomyces cerevisiae YNR019W ARE2 Acyl-CoA:sterol acyltransferase isozyme of Are1p endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; sterol acyltransferase 799209 2892270 KLLA0_C09152g Kluyveromyces lactis sterol acyltransferase XP_452607.1 797422 R 28985 CDS KLLA0_C09174g 2891816 799820..800701 C 1 NC_006039.1 similar to uniprot|P40509 Saccharomyces cerevisiae YIL076W SEC28 Part of a heptameric protein complex that regulates retrograde Golgi-to-ER protein traffic in eukaryotic cells coatomer forms the COP I vesicle coat whose functions are essential epsilon-COP coatomer subunit Sec28p; coatomer subunit epsilon 800701 2891816 KLLA0_C09174g Kluyveromyces lactis coatomer subunit epsilon XP_452608.1 799820 D 28985 CDS KLLA0_C09196g 2892018 801012..801962 C 1 NC_006039.1 similar to uniprot|P40056 Saccharomyces cerevisiae YER083C RMD7 Required for Meiotic nuclear Division functions in DNA replication and damage response Protein involved in cell wall function; GET complex subunit GET2 801962 2892018 KLLA0_C09196g Kluyveromyces lactis GET complex subunit GET2 XP_452609.1 801012 D 28985 CDS KLLA0_C09218g 2891869 complement(802178..802699) C 1 NC_006039.1 similar to uniprot|Q8PPU9 Xanthomonas axonopodis pv XAC0586 Hypothetical protein XAC0586; uncharacterized protein 802699 2891869 KLLA0_C09218g Kluyveromyces lactis uncharacterized protein XP_452610.1 802178 R 28985 CDS KLLA0_C09240g 2891871 complement(803446..804783) C 1 NC_006039.1 some similarities with uniprot|P28272 Saccharomyces cerevisiae YKL216W URA1 The enzyme catalyzes the conversion of dihydroorotic acid to orotic acid; dihydroorotate dehydrogenase; uncharacterized protein 804783 2891871 KLLA0_C09240g Kluyveromyces lactis uncharacterized protein XP_452611.1 803446 R 28985 CDS KLLA0_C09262g 2892674 805512..807188 C 1 NC_006039.1 highly similar to uniprot|P40055 Saccharomyces cerevisiae YER082C; uncharacterized protein 807188 2892674 KLLA0_C09262g Kluyveromyces lactis uncharacterized protein XP_452612.1 805512 D 28985 CDS KLLA0_C09284g 2892008 complement(807377..810178) C 1 NC_006039.1 similar to uniprot|P32565 Saccharomyces cerevisiae YIL075C RPN2 Subunit of the 26S proteasome substrate of the N-acetyltransferase Nat1p; proteasome regulatory particle base subunit RPN2 810178 2892008 KLLA0_C09284g Kluyveromyces lactis proteasome regulatory particle base subunit RPN2 XP_452613.1 807377 R 28985 CDS KLLA0_C09306g 2892263 complement(810584..811996) C 1 NC_006039.1 highly similar to uniprot|P40510 Saccharomyces cerevisiae YIL074C and to uniprot|P40054 Saccharomyces cerevisiae YER081W SER3 3-phosphoglycerate dehydrogenase, catalyze the first step in serine and glycine biosynthesis; isozyme of Ser33p; uncharacterized protein 811996 2892263 KLLA0_C09306g Kluyveromyces lactis uncharacterized protein XP_452614.1 810584 R 28985 CDS KLLA0_C09328g 2891964 complement(join(812817..815638,815744..815795)) C 1 NC_006039.1 similar to uniprot|P40511 Saccharomyces cerevisiae YIL073C SPO22; uncharacterized protein 815795 2891964 KLLA0_C09328g Kluyveromyces lactis uncharacterized protein XP_452615.2 812817 R 28985 CDS KLLA0_C09372g 2892257 816494..817378 C 1 NC_006039.1 similar to uniprot|Q75FB1 Ashbya gossypii AAL180C AAL180Cp and weakly similar to YKR011C uniprot|Q02209 Saccharomyces cerevisiae YKR011C Hypothetical ORF; chromatin-associated RNAPIII regulator FPT1 817378 2892257 KLLA0_C09372g Kluyveromyces lactis chromatin-associated RNAPIII regulator FPT1 XP_452616.1 816494 D 28985 CDS KLLA0_C09394g 2892238 817925..821479 C 1 NC_006039.1 weakly similar to uniprot|P47035 Saccharomyces cerevisiae YJL076W NET1 Core subunit of the RENT complex which is a complex involved in nucleolar silencing and telophase exit stimulates transcription by RNA polymerase I and regulates nucleolar structure; uncharacterized protein 821479 2892238 KLLA0_C09394g Kluyveromyces lactis uncharacterized protein XP_452617.1 817925 D 28985 CDS KLLA0_C09416g 2892254 complement(821606..822820) C 1 NC_006039.1 similar to uniprot|P38355 Saccharomyces cerevisiae YBR287W ZSP1; uncharacterized protein 822820 2892254 KLLA0_C09416g Kluyveromyces lactis uncharacterized protein XP_452618.1 821606 R 28985 CDS KLLA0_C09460g 2892249 complement(823980..824297) C 1 NC_006039.1 highly similar to uniprot|P48606 Saccharomyces cerevisiae YOR265W RBL2 Protein involved in microtubule morphogenesis required for protection from excess free beta-tubulin proposed to be involved the folding of beta-tubulin; uncharacterized protein 824297 2892249 KLLA0_C09460g Kluyveromyces lactis uncharacterized protein XP_452619.1 823980 R 28985 CDS KLLA0_C09482g 2892247 complement(824667..825980) C 1 NC_006039.1 weakly similar to uniprot|Q08729 Saccharomyces cerevisiae YOR264W DSE3 Daughter cell-specific protein may help establish daughter fate; uncharacterized protein 825980 2892247 KLLA0_C09482g Kluyveromyces lactis uncharacterized protein XP_452620.1 824667 R 28985 CDS KLLA0_C09504g 2892245 complement(826607..827650) C 1 NC_006039.1 highly similar to uniprot|Q08726 Saccharomyces cerevisiae YOR262W Protein required for cell viability; uncharacterized protein 827650 2892245 KLLA0_C09504g Kluyveromyces lactis uncharacterized protein XP_452621.1 826607 R 28985 CDS KLLA0_C09526g 2891966 828109..829110 C 1 NC_006039.1 highly similar to uniprot|Q6Q5I7 Saccharomyces cerevisiae YOR261C; proteasome regulatory particle lid subunit RPN8 829110 2891966 KLLA0_C09526g Kluyveromyces lactis proteasome regulatory particle lid subunit RPN8 XP_452622.1 828109 D 28985 CDS KLLA0_C09548g 2892678 829526..830884 C 1 NC_006039.1 similar to uniprot|P21592 Saccharomyces cerevisiae YPL172C COX10 Heme A:farnesyltransferase catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity human ortholog is associated with mitochondrial disorders; protoheme IX farnesyltransferase 830884 2892678 KLLA0_C09548g Kluyveromyces lactis protoheme IX farnesyltransferase XP_452623.1 829526 D 28985 CDS KLLA0_C09570g 2892473 complement(831137..832621) C 1 NC_006039.1 similar to uniprot|P09032 Saccharomyces cerevisiae YOR260W GCD1 Gamma subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression; translation initiation factor eIF2B subunit gamma 832621 2892473 KLLA0_C09570g Kluyveromyces lactis translation initiation factor eIF2B subunit gamma XP_452624.1 831137 R 28985 CDS KLLA0_C09592g 2892259 833061..834365 C 1 NC_006039.1 highly similar to uniprot|P53549 Saccharomyces cerevisiae YOR259C RPT4 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates required for spindle pole body duplication localized mainly to the nucleus throughout the cell cycle; proteasome regulatory particle base subunit RPT4 834365 2892259 KLLA0_C09592g Kluyveromyces lactis proteasome regulatory particle base subunit RPT4 XP_452625.1 833061 D 28985 CDS KLLA0_C09625g 2892498 complement(834462..835433) C 1 NC_006039.1 similar to uniprot|Q08702 Saccharomyces cerevisiae YOR258W HNT3 Member of the third branch of the histidine triad (HIT) superfamily of nucleotide-binding proteins similar to Aprataxin a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; DNA 5'-adenosine monophosphate hydrolase 835433 2892498 KLLA0_C09625g Kluyveromyces lactis DNA 5'-adenosine monophosphate hydrolase XP_452627.1 834462 R 28985 CDS KLLA0_C09647g 2891873 complement(835665..836555) C 1 NC_006039.1 similar to uniprot|P36534 Saccharomyces cerevisiae YPL173W MRPL40 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein uL24m 836555 2891873 KLLA0_C09647g Kluyveromyces lactis mitochondrial 54S ribosomal protein uL24m XP_452628.1 835665 R 28985 CDS KLLA0_C09669g 2892242 complement(836857..837360) C 1 NC_006039.1 similar to uniprot|P06704 Saccharomyces cerevisiae YOR257W CDC31 Component of the spindle pole body (SPB) half-bridge required for SPB duplication in mitosis and meiosis II homolog of mammalian centrin interacts with Kar1p; centrin 837360 2892242 KLLA0_C09669g Kluyveromyces lactis centrin XP_452629.1 836857 R 28985 CDS KLLA0_C09691g 2891813 837629..840094 C 1 NC_006039.1 weakly similar to uniprot|P33420 Saccharomyces cerevisiae YPL174C NIP100 Large subunit of the dynactin complex which is involved in partitioning the mitotic spindle between mother and daughter cells putative ortholog of mammalian p150(glued); uncharacterized protein 840094 2891813 KLLA0_C09691g Kluyveromyces lactis uncharacterized protein XP_452630.1 837629 D 28985 CDS KLLA0_C09713g 2891867 complement(840112..841452) C 1 NC_006039.1 similar to uniprot|P32363 Saccharomyces cerevisiae YPL175W SPT14 UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis mutations cause defects in transcription and in biogenesis of cell wall proteins; phosphatidylinositol N-acetylglucosaminyltransferase SPT14 841452 2891867 KLLA0_C09713g Kluyveromyces lactis phosphatidylinositol N-acetylglucosaminyltransferase SPT14 XP_452631.1 840112 R 28985 CDS KLLA0_C09735g 2891815 841867..844221 C 1 NC_006039.1 similar to uniprot|Q08693 Saccharomyces cerevisiae YOR256C Protein required for cell viability; uncharacterized protein 844221 2891815 KLLA0_C09735g Kluyveromyces lactis uncharacterized protein XP_452632.1 841867 D 28985 CDS KLLA0_C09757g 2891823 844760..845218 C 1 NC_006039.1 highly similar to uniprot|Q12091 Saccharomyces cerevisiae YPL170W DAP1 Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p damage response protein related to mammalian membrane progesterone receptors mutations lead to defects in telomeres mitochondria and sterol synthesis; uncharacterized protein 845218 2891823 KLLA0_C09757g Kluyveromyces lactis uncharacterized protein XP_452633.1 844760 D 28985 CDS KLLA0_C09779g 2891933 complement(845329..845979) C 1 NC_006039.1 weakly similar to uniprot|Q08692 Saccharomyces cerevisiae YOR255W OSW1 Protein of unknown function required for the construction of the outer spore wall layers; uncharacterized protein 845979 2891933 KLLA0_C09779g Kluyveromyces lactis uncharacterized protein XP_452634.1 845329 R 28985 CDS KLLA0_C09801g 2891834 complement(846302..848068) C 1 NC_006039.1 similar to uniprot|Q99257 Saccharomyces cerevisiae YPL169C MEX67 Poly(A)RNA binding protein involved in nuclear mRNA export component of the nuclear pore ortholog of human TAP; uncharacterized protein 848068 2891834 KLLA0_C09801g Kluyveromyces lactis uncharacterized protein XP_452635.1 846302 R 28985 CDS KLLA0_C09823g 2892218 848641..850650 C 1 NC_006039.1 similar to uniprot|P14906 Saccharomyces cerevisiae YOR254C SEC63 Essential subunit of Sec63 complex (Sec63p Sec62p Sec66p and Sec72p) with Sec61 complex Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; protein-transporting protein SEC63 850650 2892218 KLLA0_C09823g Kluyveromyces lactis protein-transporting protein SEC63 XP_452636.1 848641 D 28985 CDS KLLA0_C09845g 2892220 complement(850737..851228) C 1 NC_006039.1 similar to uniprot|Q08689 Saccharomyces cerevisiae YOR253W NAT5 Subunit of the N-terminal acetyltransferase NatA (Nat1p Ard1p Nat5p) N-terminally acetylates many proteins which influences multiple processes such as the cell cycle heat- shock resistance mating sporulation and telomeric silencing; peptide alpha-N-acetyltransferase subunit NAT5 851228 2892220 KLLA0_C09845g Kluyveromyces lactis peptide alpha-N-acetyltransferase subunit NAT5 XP_452637.1 850737 R 28985 CDS KLLA0_C09867g 2892228 851501..852649 C 1 NC_006039.1 some similarities with uniprot|Q12467 Saccharomyces cerevisiae YPL168W; uncharacterized protein 852649 2892228 KLLA0_C09867g Kluyveromyces lactis uncharacterized protein XP_452638.1 851501 D 28985 CDS KLLA0_C09889g 2891836 complement(852807..853379) C 1 NC_006039.1 similar to uniprot|Q08687 Saccharomyces cerevisiae YOR252W RBF17 Hypothetical ORF; uncharacterized protein 853379 2891836 KLLA0_C09889g Kluyveromyces lactis uncharacterized protein XP_452639.1 852807 R 28985 CDS KLLA0_C09911g 2891858 complement(853608..857963) C 1 NC_006039.1 similar to uniprot|P14284 Saccharomyces cerevisiae YPL167C REV3 Subunit of DNA polymerase zeta which is involved in DNA repair required for mutagenesis induced by DNA damage; DNA-directed DNA polymerase 857963 2891858 KLLA0_C09911g Kluyveromyces lactis DNA-directed DNA polymerase XP_452640.1 853608 R 28985 CDS KLLA0_C09933g 2891821 858405..858869 C 1 NC_006039.1 weakly similar to uniprot|Q12092 Saccharomyces cerevisiae YPL166W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; uncharacterized protein 858869 2891821 KLLA0_C09933g Kluyveromyces lactis uncharacterized protein XP_452641.1 858405 D 28985 CDS KLLA0_C09944g 2892091 complement(858858..859961) C 1 NC_006039.1 similar to uniprot|Q12529 Saccharomyces cerevisiae YPL165C SET6; uncharacterized protein 859961 2892091 KLLA0_C09944g Kluyveromyces lactis uncharacterized protein XP_452642.1 858858 R 28985 CDS KLLA0_C09966g 2892099 860413..861312 C 1 NC_006039.1 similar to uniprot|Q08686 Saccharomyces cerevisiae YOR251C catalyzes transfer of the sulfane atom of thiosulfate to cyanide to form sulfite and thiocyanate; thiosulfate sulfurtransferase 861312 2892099 KLLA0_C09966g Kluyveromyces lactis thiosulfate sulfurtransferase XP_452643.1 860413 D 28985 CDS KLLA0_C09988g 2892097 861625..862938 C 1 NC_006039.1 similar to uniprot|Q08685 Saccharomyces cerevisiae YOR250C CLP1 cleavage/polyadenylation factor IA subunit interacts with Pcf11p in the 2-hybrid system cleavage/polyadenylation factor IA subunit; cleavage polyadenylation factor subunit CLP1 862938 2892097 KLLA0_C09988g Kluyveromyces lactis cleavage polyadenylation factor subunit CLP1 XP_452644.1 861625 D 28985 CDS KLLA0_C10010g 2892227 863101..864906 C 1 NC_006039.1 weakly similar to uniprot|Q08683 Saccharomyces cerevisiae YOR249C APC5 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition; anaphase promoting complex subunit 5 864906 2892227 KLLA0_C10010g Kluyveromyces lactis anaphase promoting complex subunit 5 XP_452645.1 863101 D 28985 CDS KLLA0_C10032g 2892630 complement(864922..867036) C 1 NC_006039.1 similar to uniprot|Q12083 Saccharomyces cerevisiae YPL164C MLH3 Protein involved in DNA mismatch repair forms a complex with Mlh1p to promote meiotic crossing-over mammalian homolog is implicated mammalian microsatellite instability; mismatch repair protein MLH3 867036 2892630 KLLA0_C10032g Kluyveromyces lactis mismatch repair protein MLH3 XP_452646.1 864922 R 28985 CDS KLLA0_C10054g 2891866 complement(867386..868093) C 1 NC_006039.1 no similarity; uncharacterized protein 868093 2891866 KLLA0_C10054g Kluyveromyces lactis uncharacterized protein XP_452647.1 867386 R 28985 CDS KLLA0_C10076g 2892219 complement(869088..869918) C 1 NC_006039.1 similar to uniprot|Q12042 Saccharomyces cerevisiae YPL162C Hypothetical ORF; uncharacterized protein 869918 2892219 KLLA0_C10076g Kluyveromyces lactis uncharacterized protein XP_452648.1 869088 R 28985 CDS KLLA0_C10098g 2892224 complement(870147..871973) C 1 NC_006039.1 similar to uniprot|P39011 Saccharomyces cerevisiae YPL161C BEM4 Protein involved in establishment of cell polarity and bud emergence interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; uncharacterized protein 871973 2892224 KLLA0_C10098g Kluyveromyces lactis uncharacterized protein XP_452649.1 870147 R 28985 CDS KLLA0_C10120g 2891868 872435..873715 C 1 NC_006039.1 similar to uniprot|Q06640 Saccharomyces cerevisiae YDR306C Hypothetical ORF; uncharacterized protein 873715 2891868 KLLA0_C10120g Kluyveromyces lactis uncharacterized protein XP_452650.1 872435 D 28985 CDS KLLA0_C10142g 2892626 join(873948..874004,874115..874630) C 1 NC_006039.1 similar to uniprot|P49775 Saccharomyces cerevisiae YDR305C HNT2 Dinucleoside triphosphate hydrolase; bis(5'-adenosyl)-triphosphatase 874630 2892626 KLLA0_C10142g Kluyveromyces lactis bis(5'-adenosyl)-triphosphatase XP_452651.1 873948 D 28985 CDS KLLA0_C10164g 2892010 complement(874796..875173) C 1 NC_006039.1 similar to uniprot|Q75EY2 Ashbya gossypii AAL054W AAL054Wp and some similarites with YHR059W uniprot|P38783 Saccharomyces cerevisiae YHR059W FYV4 Protein of unknown function required for survival upon exposure to K1 killer toxin; mitochondrial 37S ribosomal protein mS41 875173 2892010 KLLA0_C10164g Kluyveromyces lactis mitochondrial 37S ribosomal protein mS41 XP_452652.1 874796 R 28985 CDS KLLA0_C10186g 2892222 875492..876298 C 1 NC_006039.1 similar to uniprot|P38782 Saccharomyces cerevisiae YHR058C MED6 RNA polymerase II transcriptional regulation mediator RNA polymerase II mediator subunit; mediator complex subunit MED6 876298 2892222 KLLA0_C10186g Kluyveromyces lactis mediator complex subunit MED6 XP_452653.1 875492 D 28985 CDS KLLA0_C10208g 2892230 876495..877100 C 1 NC_006039.1 similar to uniprot|P35176 Saccharomyces cerevisiae YDR304C CPR5 Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues transcriptionally induced in response to unfolded proteins in the ER; peptidylprolyl isomerase family protein CPR5 877100 2892230 KLLA0_C10208g Kluyveromyces lactis peptidylprolyl isomerase family protein CPR5 XP_452654.1 876495 D 28985 CDS KLLA0_C10230g 2891852 877485..878324 C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 878324 2891852 KLLA0_C10230g Kluyveromyces lactis uncharacterized protein XP_452655.1 877485 D 28985 CDS KLLA0_C10252g 2892225 complement(878425..879078) C 1 NC_006039.1 similar to uniprot|Q06636 Saccharomyces cerevisiae YDR302W GPI11 ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate human PIG-Fp is a functional homolog; GPI11 ER membrane protein; mannose-ethanolamine phosphotransferase GPI11 879078 2892225 KLLA0_C10252g Kluyveromyces lactis mannose-ethanolamine phosphotransferase GPI11 XP_452656.1 878425 R 28985 CDS KLLA0_C10274g 2892237 complement(879403..883305) C 1 NC_006039.1 similar to uniprot|Q06632 Saccharomyces cerevisiae YDR301W CFT1 Functions in cleavage of 3'-ends of pre-mRNAs prior to polyadenylation 23.5% identical to the 160-kDa subunit of mammalian cleavage and polyadenylation specificity factor (CPSF-160) Component of pre-mRNA cleavage factor II (CFII) 150-kDa protein associated with polyadenylation factor 1 (PF I); cleavage/polyadenylation factor CFT1 883305 2892237 KLLA0_C10274g Kluyveromyces lactis cleavage/polyadenylation factor CFT1 XP_452657.1 879403 R 28985 CDS KLLA0_C10296g 2891953 883644..884900 C 1 NC_006039.1 highly similar to uniprot|P32264 Saccharomyces cerevisiae YDR300C PRO1 Gamma-glutamyl kinase catalyzes the first step in proline biosynthesis and to YHR033W uniprot|P38690 Saccharomyces cerevisiae YHR033W Hypothetical ORF; glutamate 5-kinase 884900 2891953 KLLA0_C10296g Kluyveromyces lactis glutamate 5-kinase XP_452658.1 883644 D 28985 CDS KLLA0_C10318g 2891957 complement(885031..886032) C 1 NC_006039.1 similar to uniprot|P38768 Saccharomyces cerevisiae YHR034C PIH1 Protein of unresolved function may function in protein folding and/or rRNA processing interacts with a chaperone (Hsp82p) two chromatin remodeling factors (Rvb1p Rvb2p) and two rRNA processing factors (Rrp43p Nop58p); uncharacterized protein 886032 2891957 KLLA0_C10318g Kluyveromyces lactis uncharacterized protein XP_452659.1 885031 R 28985 CDS KLLA0_C10340g 2891830 886390..888015 C 1 NC_006039.1 similar to uniprot|Q05497 Saccharomyces cerevisiae YDR338C; uncharacterized protein 888015 2891830 KLLA0_C10340g Kluyveromyces lactis uncharacterized protein XP_452660.1 886390 D 28985 CDS KLLA0_C10362g 2892016 complement(888123..889703) C 1 NC_006039.1 similar to uniprot|Q66RD8 Saccharomyces cerevisiae YDR299W BFR2 Essential protein possibly involved in secretion multicopy suppressor of sensitivity to Brefeldin A; rRNA-processing protein BFR2 889703 2892016 KLLA0_C10362g Kluyveromyces lactis rRNA-processing protein BFR2 XP_452661.1 888123 R 28985 CDS KLLA0_C10384g 2891844 890604..891224 C 1 NC_006039.1 uniprot|O74190 Kluyveromyces lactis KLLA0C10384g ATP5 ATP synthase subunit 5, mitochondrial precursor; F1F0 ATP synthase subunit 5 891224 2891844 KLLA0_C10384g Kluyveromyces lactis F1F0 ATP synthase subunit 5 XP_452662.1 890604 D 28985 CDS KLLA0_C10406g 2891958 complement(892040..893059) C 1 NC_006039.1 similar to uniprot|P38992 Saccharomyces cerevisiae YDR297W SUR2 Sphingosine hydroxylase has a role in sphingolipid metabolism catalyses the conversion of sphinganine to phytosphingosine; sphingosine hydroxylase 893059 2891958 KLLA0_C10406g Kluyveromyces lactis sphingosine hydroxylase XP_452663.1 892040 R 28985 CDS KLLA0_C10439g 2891994 complement(893936..894595) C 1 NC_006039.1 similar to uniprot|Q06630 Saccharomyces cerevisiae YDR296W MHR1 Protein involved in homologous recombination in mitochondria and in transcription regulation in nucleus binds to activation domains of acidic activators required for recombination-dependent mtDNA partitioning; mitochondrial 54S ribosomal protein mL67 894595 2891994 KLLA0_C10439g Kluyveromyces lactis mitochondrial 54S ribosomal protein mL67 XP_452665.1 893936 R 28985 CDS KLLA0_C10461g 2891807 895022..897010 C 1 NC_006039.1 weakly similar to uniprot|P38769 Saccharomyces cerevisiae YHR035W Hypothetical ORF; GTPase-activating protein NEL1 897010 2891807 KLLA0_C10461g Kluyveromyces lactis GTPase-activating protein NEL1 XP_452666.1 895022 D 28985 CDS KLLA0_C10483g 2891955 897356..899260 C 1 NC_006039.1 similar to uniprot|Q06629 YDR295C Saccharomyces cerevisiae YDR295C HDA2 Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda3p; Ploidy-related; uncharacterized protein 899260 2891955 KLLA0_C10483g Kluyveromyces lactis uncharacterized protein XP_452667.1 897356 D 28985 CDS KLLA0_C10505g 2891993 899784..901532 C 1 NC_006039.1 similar to uniprot|Q05567 Saccharomyces cerevisiae YDR294C DPL1 Dihydrosphingosine phosphate lyase regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs) degrades phosphorylated long chain bases prefers C16 dihydrosphingosine-l-phosphate as a substrate; sphinganine-1-phosphate aldolase DPL1 901532 2891993 KLLA0_C10505g Kluyveromyces lactis sphinganine-1-phosphate aldolase DPL1 XP_452668.1 899784 D 28985 CDS KLLA0_C10527g 2892258 901896..903242 C 1 NC_006039.1 similar to uniprot|P38770 Saccharomyces cerevisiae YHR036W Protein required for cell viability; uncharacterized protein 903242 2892258 KLLA0_C10527g Kluyveromyces lactis uncharacterized protein XP_452669.1 901896 D 28985 CDS KLLA0_C10549g 2892659 903888..905618 C 1 NC_006039.1 highly similar to uniprot|P07275 Saccharomyces cerevisiae YHR037W PUT2 delta-1-pyrroline-5-carboxylate dehydrogenase; 1-pyrroline-5-carboxylate dehydrogenase 905618 2892659 KLLA0_C10549g Kluyveromyces lactis 1-pyrroline-5-carboxylate dehydrogenase XP_452670.1 903888 D 28985 CDS KLLA0_C10571g 2892622 906848..910381 C 1 NC_006039.1 similar to uniprot|P24276 Saccharomyces cerevisiae YDR293C SSD1 Protein with a role in maintenance of cellular integrity interacts with components of the TOR pathway ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence; mRNA-binding translational repressor SSD1 910381 2892622 KLLA0_C10571g Kluyveromyces lactis mRNA-binding translational repressor SSD1 XP_452671.1 906848 D 28985 CDS KLLA0_C10593g 2892251 911134..911859 C 1 NC_006039.1 similar to uniprot|P38771 Saccharomyces cerevisiae YHR038W RRF1 Ribosomal Recycling Factor 1 originally characterized as FIL1 a Factor for Isocitrate Lyase expression mitochondrial ribosome recycling factor; uncharacterized protein 911859 2892251 KLLA0_C10593g Kluyveromyces lactis uncharacterized protein XP_452672.1 911134 D 28985 CDS KLLA0_C10615g 2892255 complement(912077..913999) C 1 NC_006039.1 similar to uniprot|P38694 Saccharomyces cerevisiae YHR039C MSC7 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum msc7 mutants are defective in directing meiotic recombination events to homologous chromatids; meiotic recombination directing protein 913999 2892255 KLLA0_C10615g Kluyveromyces lactis meiotic recombination directing protein XP_452673.1 912077 R 28985 CDS KLLA0_C10670g 2892232 complement(join(914466..914804,914891..914893)) C 1 NC_006039.1 similar to uniprot|P48836 Saccharomyces cerevisiae YHR039C-A VMA10 Vacuolar H+ ATPase subunit G of the catalytic (V1) sector; H(+)-transporting V1 sector ATPase subunit G 914893 2892232 KLLA0_C10670g Kluyveromyces lactis H(+)-transporting V1 sector ATPase subunit G XP_452674.2 914466 R 28985 CDS KLLA0_C10681g 2891809 915315..916583 C 1 NC_006039.1 similar to uniprot|P38772 Saccharomyces cerevisiae YHR040W BCD1 Essential protein required for the accumulation of box C/D snoRNA; uncharacterized protein 916583 2891809 KLLA0_C10681g Kluyveromyces lactis uncharacterized protein XP_452675.1 915315 D 28985 CDS KLLA0_C10692g 2892253 complement(916718..918280) C 1 NC_006039.1 weakly similar to uniprot|P21147 Saccharomyces cerevisiae YGL055W OLE1 Fatty acid desaturase required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria; uncharacterized protein 918280 2892253 KLLA0_C10692g Kluyveromyces lactis uncharacterized protein XP_452676.1 916718 R 28985 CDS KLLA0_C10714g 2892040 919128..920930 C 1 NC_006039.1 similar to uniprot|P32916 Saccharomyces cerevisiae YDR292C SRP101 Signal recognition particle (SRP) receptor - alpha subunit contain GTPase domains involved in SRP-dependent protein targeting interacts with SRP102p; Signal recognition particle receptor subunit alpha 920930 2892040 KLLA0_C10714g Kluyveromyces lactis Signal recognition particle receptor subunit alpha XP_452677.1 919128 D 28985 CDS KLLA0_C10736g 2891848 complement(921019..924258) C 1 NC_006039.1 similar to uniprot|Q05549 Saccharomyces cerevisiae YDR291W Hypothetical ORF; ATP-dependent 3'-5' DNA helicase 924258 2891848 KLLA0_C10736g Kluyveromyces lactis ATP-dependent 3'-5' DNA helicase XP_452678.1 921019 R 28985 CDS KLLA0_C10758g 2892199 924736..925824 C 1 NC_006039.1 similar to uniprot|Q05543 Saccharomyces cerevisiae YDR289C RTT103 Regulator of Ty1 Transposition regulator of Ty1 Transposition; uncharacterized protein 925824 2892199 KLLA0_C10758g Kluyveromyces lactis uncharacterized protein XP_452679.1 924736 D 28985 CDS KLLA0_C10780g 2891888 complement(join(925855..926476,926561..926574)) C 1 NC_006039.1 similar to uniprot|P34162 Saccharomyces cerevisiae YHR041C SRB2 RNA polymerase II holoenzyme/mediator subunit; uncharacterized protein 926574 2891888 KLLA0_C10780g Kluyveromyces lactis uncharacterized protein XP_452680.1 925855 R 28985 CDS KLLA0_C10802g 2891894 complement(926916..931934) C 1 NC_006039.1 similar to uniprot|P15442 Saccharomyces cerevisiae YDR283C GCN2 Protein kinase phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; serine/threonine-protein kinase GCN2 931934 2891894 KLLA0_C10802g Kluyveromyces lactis serine/threonine-protein kinase GCN2 XP_452681.1 926916 R 28985 CDS KLLA0_C10835g 2892645 complement(932418..933311) C 1 NC_006039.1 similar to uniprot|Q05521 Saccharomyces cerevisiae YDR284C DPP1 Diacylglycerol pyrophosphate (DGPP) phosphatase zinc- regulated vacuolar membrane-associated lipid phosphatase dephosphorylates DGPP to phosphatidate (PA) and Pi then PA to diacylglycerol involved in lipid signaling and cell metabolism; bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase 933311 2892645 KLLA0_C10835g Kluyveromyces lactis bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase XP_452683.1 932418 R 28985 CDS KLLA0_C10857g 2892465 934234..935595 C 1 NC_006039.1 similar to uniprot|P28625 Saccharomyces cerevisiae YMR152W; uncharacterized protein 935595 2892465 KLLA0_C10857g Kluyveromyces lactis uncharacterized protein XP_452684.1 934234 D 28985 CDS KLLA0_C10879g 2892692 936212..938479 C 1 NC_006039.1 weakly similar to uniprot|P31111 Saccharomyces cerevisiae YDR285W ZIP1 Synaptonemal complex (SC) protein that connects homologous chromosomes partially during zygotene and entirely during pachytene potential Cdc28p substrate synaptonemal complex protein; uncharacterized protein 938479 2892692 KLLA0_C10879g Kluyveromyces lactis uncharacterized protein XP_452685.1 936212 D 28985 CDS KLLA0_C10901g 2892655 complement(938502..938837) C 1 NC_006039.1 similar to uniprot|Q05530 Saccharomyces cerevisiae YDR286C Hypothetical ORF; uncharacterized protein 938837 2892655 KLLA0_C10901g Kluyveromyces lactis uncharacterized protein XP_452686.1 938502 R 28985 CDS KLLA0_C10923g 2892636 complement(939148..941475) C 1 NC_006039.1 weakly similar to uniprot|P07272 Saccharomyces cerevisiae YLR014C PPR1 Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain positively regulates transcription of genes involved in uracil biosynthesis activity may be modulated by interaction with Tup1p; uncharacterized protein 941475 2892636 KLLA0_C10923g Kluyveromyces lactis uncharacterized protein XP_452687.1 939148 R 28985 CDS KLLA0_C10945g 2892484 941764..942981 C 1 NC_006039.1 similar to YLR015W, uniprot|P43132 Saccharomyces cerevisiae YLR015W (BRE2); uncharacterized protein 942981 2892484 KLLA0_C10945g Kluyveromyces lactis uncharacterized protein XP_452688.1 941764 D 28985 CDS KLLA0_C10967g 2892039 943312..944514 C 1 NC_006039.1 similar to uniprot|P47057 Saccharomyces cerevisiae YJL036W SNX4 Sorting NeXin; uncharacterized protein 944514 2892039 KLLA0_C10967g Kluyveromyces lactis uncharacterized protein XP_452689.1 943312 D 28985 CDS KLLA0_C10989g 2892025 complement(944739..945455) C 1 NC_006039.1 similar to uniprot|P47058 Saccharomyces cerevisiae YJL035C TAD2 tRNA-specific adenosine-34 deaminase subunit Tad2p; tRNA(adenine34) deaminase 945455 2892025 KLLA0_C10989g Kluyveromyces lactis tRNA(adenine34) deaminase XP_452690.1 944739 R 28985 CDS KLLA0_C11011g 2892037 complement(945689..946417) C 1 NC_006039.1 highly similar to uniprot|P38777 Saccharomyces cerevisiae YHR049W; uncharacterized protein 946417 2892037 KLLA0_C11011g Kluyveromyces lactis uncharacterized protein XP_452691.1 945689 R 28985 CDS KLLA0_C11033g 2891889 947926..950505 C 1 NC_006039.1 highly similar to uniprot|P32454 Saccharomyces cerevisiae YKL157W APE2 Zinc-dependent metallopeptidase yscII and to uniprot|P37898 Saccharomyces cerevisiae YHR047C AAP1' Arginine/alanine aminopeptidase; uncharacterized protein 950505 2891889 KLLA0_C11033g Kluyveromyces lactis uncharacterized protein XP_452692.2 947926 D 28985 CDS KLLA0_C11055g 2892019 complement(950647..952293) C 1 NC_006039.1 similar to uniprot|P38775 Saccharomyces cerevisiae YHR045W Hypothetical ORF; uncharacterized protein 952293 2892019 KLLA0_C11055g Kluyveromyces lactis uncharacterized protein XP_452693.1 950647 R 28985 CDS KLLA0_C11077g 2891857 952702..953715 C 1 NC_006039.1 weakly similar to uniprot|Q6Q5R1 Saccharomyces cerevisiae YDR279W RNH202 Ribonuclease H2 subunit required for RNase H2 activity; uncharacterized protein 953715 2891857 KLLA0_C11077g Kluyveromyces lactis uncharacterized protein XP_452694.1 952702 D 28985 CDS KLLA0_C11099g 2892669 954057..954974 C 1 NC_006039.1 highly similar to uniprot|Q05636 Saccharomyces cerevisiae YDR280W RRP45 Ribosomal RNA Processing Putative 3'->5' exoribonuclease component of exosome complex of 3'->5' exonucleases; exosome non-catalytic core subunit RRP45 954974 2892669 KLLA0_C11099g Kluyveromyces lactis exosome non-catalytic core subunit RRP45 XP_452695.1 954057 D 28985 CDS KLLA0_C11121g 2892285 complement(955199..955576) C 1 NC_006039.1 no similarity; uncharacterized protein 955576 2892285 KLLA0_C11121g Kluyveromyces lactis uncharacterized protein XP_452696.1 955199 R 28985 CDS KLLA0_C11143g 2892506 956474..957280 C 1 NC_006039.1 similar to uniprot|P38773 Saccharomyces cerevisiae and to YHR044C uniprot|P38774 Saccharomyces cerevisiae DOG1 2- deoxyglucose-6-phosphate phosphatase; uncharacterized protein 957280 2892506 KLLA0_C11143g Kluyveromyces lactis uncharacterized protein XP_452697.1 956474 D 28985 CDS KLLA0_C11165g 2892266 complement(957421..958491) C 1 NC_006039.1 similar to uniprot|Q05648 Saccharomyces cerevisiae YDR282C Hypothetical ORF; uncharacterized protein 958491 2892266 KLLA0_C11165g Kluyveromyces lactis uncharacterized protein XP_452698.1 957421 R 28985 CDS KLLA0_C11187g 2891942 959457..962360 C 1 NC_006039.1 similar to uniprot|Q12252 Saccharomyces cerevisiae YOL084W PHM7 Protein of unknown function expression is regulated by phosphate levels green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; uncharacterized protein 962360 2891942 KLLA0_C11187g Kluyveromyces lactis uncharacterized protein XP_452699.1 959457 D 28985 CDS KLLA0_C11209g 2892287 962988..964871 C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 964871 2892287 KLLA0_C11209g Kluyveromyces lactis uncharacterized protein XP_452700.1 962988 D 28985 CDS KLLA0_C11231g 2891963 965524..966840 C 1 NC_006039.1 highly similar to uniprot|P12385 Saccharomyces cerevisiae YBR143C SUP45 Translation release factor involved in translation termination mutant form acts as a recessive omnipotent suppressor; translation termination factor eRF1 966840 2891963 KLLA0_C11231g Kluyveromyces lactis translation termination factor eRF1 XP_452701.1 965524 D 28985 CDS KLLA0_C11253g 2891940 complement(967067..969457) C 1 NC_006039.1 similar to uniprot|P38112 Saccharomyces cerevisiae YBR142W MAK5 Essential nucleolar protein putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus involved in biogenesis of large (60S) ribosomal subunits; uncharacterized protein 969457 2891940 KLLA0_C11253g Kluyveromyces lactis uncharacterized protein XP_452702.1 967067 R 28985 CDS KLLA0_C11275g 2892137 969789..970853 C 1 NC_006039.1 similar to uniprot|P38278 Saccharomyces cerevisiae YBR141C Hypothetical ORF; 25S rRNA (adenine2142-N1)-methyltransferase 970853 2892137 KLLA0_C11275g Kluyveromyces lactis 25S rRNA (adenine2142-N1)-methyltransferase XP_452703.1 969789 D 28985 CDS KLLA0_C11297g 2891875 971068..971481 C 1 NC_006039.1 similar to uniprot|P53937 Saccharomyces cerevisiae YNL081C SWS2; mitochondrial 37S ribosomal protein uS13m 971481 2891875 KLLA0_C11297g Kluyveromyces lactis mitochondrial 37S ribosomal protein uS13m XP_452704.1 971068 D 28985 CDS KLLA0_C11319g 2891896 complement(971620..974391) C 1 NC_006039.1 similar to uniprot|P14242 Saccharomyces cerevisiae, YNL082W; ATP-binding mismatch repair protein 974391 2891896 KLLA0_C11319g Kluyveromyces lactis ATP-binding mismatch repair protein XP_452705.1 971620 R 28985 CDS KLLA0_C11341g 2891895 974626..975321 C 1 NC_006039.1 similar to uniprot|P38927 Saccharomyces cerevisiae YIL139C REV7 Subunit of DNA polymerase zeta which is involved in DNA repair required for mutagenesis induced by DNA damage; uncharacterized protein 975321 2891895 KLLA0_C11341g Kluyveromyces lactis uncharacterized protein XP_452706.1 974626 D 28985 CDS KLLA0_C11363g 2892519 complement(975442..976995) C 1 NC_006039.1 similar to uniprot|P48233 Saccharomyces cerevisiae YNL083W SAL1 Probable transporter member of the Ca2 - binding subfamily of the mitochondrial carrier family with two EF-hand motifs Pet9p and Sal1p have an overlapping function critical for viability polymorphic in different S. cerevisiae strains; Ca(2+)-binding ATP:ADP antiporter SAL1 976995 2892519 KLLA0_C11363g Kluyveromyces lactis Ca(2+)-binding ATP:ADP antiporter SAL1 XP_452707.1 975442 R 28985 CDS KLLA0_C11385g 2891976 978786..980387 C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 980387 2891976 KLLA0_C11385g Kluyveromyces lactis uncharacterized protein XP_452708.1 978786 D 28985 CDS KLLA0_C11407g 2891968 complement(980649..983006) C 1 NC_006039.1 some similarities with uniprot|P38928 Saccharomyces cerevisiae YIL140W AXL2 Integral plasma membrane protein required for axial budding in haploid cells localizes to the incipient bud site and bud neck glycosylated by Pmt4p potential Cdc28p substrate; uncharacterized protein 983006 2891968 KLLA0_C11407g Kluyveromyces lactis uncharacterized protein XP_452709.1 980649 R 28985 CDS KLLA0_C11429g 2892454 984117..985259 C 1 NC_006039.1 similar to uniprot|P39013 Saccharomyces cerevisiae YNL084C END3 EH domain-containing protein involved in endocytosis actin cytoskeletal organization and cell wall morphogenesis forms a complex with Sla1p and Pan1p; uncharacterized protein 985259 2892454 KLLA0_C11429g Kluyveromyces lactis uncharacterized protein XP_452710.1 984117 D 28985 CDS KLLA0_C11451g 2891861 complement(985410..986999) C 1 NC_006039.1 highly similar to uniprot|P39076 Saccharomyces cerevisiae YIL142W CCT2 Subunit beta of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo; chaperonin-containing T-complex subunit CCT2 986999 2891861 KLLA0_C11451g Kluyveromyces lactis chaperonin-containing T-complex subunit CCT2 XP_452711.1 985410 R 28985 CDS KLLA0_C11473g 2891841 complement(987546..989264) C 1 NC_006039.1 similar to uniprot|P53180 Saccharomyces cerevisiae YGL045W RIM8; uncharacterized protein 989264 2891841 KLLA0_C11473g Kluyveromyces lactis uncharacterized protein XP_452712.1 987546 R 28985 CDS KLLA0_C11495g 2891960 complement(990832..992169) C 1 NC_006039.1 some similarities with uniprot|P27476 Saccharomyces cerevisiae YGR159C NSR1 Nucleolar protein that binds nuclear localization sequences required for pre-rRNA processing and ribosome biogenesis; uncharacterized protein 992169 2891960 KLLA0_C11495g Kluyveromyces lactis uncharacterized protein XP_452713.1 990832 R 28985 CDS KLLA0_C11517g 2891947 complement(993074..994636) C 1 NC_006039.1 no similarity; uncharacterized protein 994636 2891947 KLLA0_C11517g Kluyveromyces lactis uncharacterized protein XP_452714.1 993074 R 28985 CDS KLLA0_C11539g 2892004 complement(995618..996529) C 1 NC_006039.1 some similarities with YGR161c, uniprot|Q7ZA12 Saccharomyces cerevisiae Hypothetical ORF, RTS3 SGDID:S0003393; uncharacterized protein 996529 2892004 KLLA0_C11539g Kluyveromyces lactis uncharacterized protein XP_452715.1 995618 R 28985 CDS KLLA0_C11561g 2891915 complement(997866..998933) C 1 NC_006039.1 no similarity; uncharacterized protein 998933 2891915 KLLA0_C11561g Kluyveromyces lactis uncharacterized protein XP_452716.1 997866 R 28985 CDS KLLA0_C11583g 2891863 complement(999466..1001553) C 1 NC_006039.1 similar to uniprot|Q752T1 Ashbya gossypii AFR492W AFR492Wp and weakly similar to YGL021W uniprot|P43633 Saccharomyces cerevisiae YGL021W ALK1 leucine zipper (putative) membrane protein (putative) and YBL009W uniprot|P32789 Saccharomyces cerevisiae YBL009W haspin; protein kinase ALK1 1001553 2891863 KLLA0_C11583g Kluyveromyces lactis protein kinase ALK1 XP_452717.1 999466 R 28985 CDS KLLA0_C11605g 2892600 1002022..1002807 C 1 NC_006039.1 weakly similar to uniprot|P32788 Saccharomyces cerevisiae YBL010C; uncharacterized protein 1002807 2892600 KLLA0_C11605g Kluyveromyces lactis uncharacterized protein XP_452718.1 1002022 D 28985 CDS KLLA0_C11627g 2892030 complement(1002978..1005254) C 1 NC_006039.1 similar to uniprot|P39007 Saccharomyces cerevisiae YGL022W STT3 Subunit of the oligosaccharyltransferase complex of the ER lumen; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3 1005254 2892030 KLLA0_C11627g Kluyveromyces lactis dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3 XP_452719.1 1002978 R 28985 CDS KLLA0_C11649g 2891979 complement(1005591..1006307) C 1 NC_006039.1 similar to uniprot|P32656 Saccharomyces cerevisiae YER163C Hypothetical ORF; gamma-glutamylcyclotransferase 1006307 2891979 KLLA0_C11649g Kluyveromyces lactis gamma-glutamylcyclotransferase XP_452720.1 1005591 R 28985 CDS KLLA0_C11671g 2892507 complement(1006574..1007575) C 1 NC_006039.1 highly similar to uniprot|P40093 Saccharomyces cerevisiae YER156C Hypothetical ORF; uncharacterized protein 1007575 2892507 KLLA0_C11671g Kluyveromyces lactis uncharacterized protein XP_452721.1 1006574 R 28985 CDS KLLA0_C11693g 2891883 1008096..1008494 C 1 NC_006039.1 similar to uniprot|P38958 Saccharomyces cerevisiae YDR079W PET100 Chaperone that specifically facilitates the assembly of cytochrome c oxidase located in the mitochondrial inner membrane; uncharacterized protein 1008494 2891883 KLLA0_C11693g Kluyveromyces lactis uncharacterized protein XP_452722.1 1008096 D 28985 CDS KLLA0_C11715g 2892552 1008738..1010867 C 1 NC_006039.1 similar to uniprot|P40094 Saccharomyces cerevisiae YER157W COG3 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; Golgi transport complex subunit COG3 1010867 2892552 KLLA0_C11715g Kluyveromyces lactis Golgi transport complex subunit COG3 XP_452723.1 1008738 D 28985 CDS KLLA0_C11737g 2892593 complement(1010903..1011121) C 1 NC_006039.1 highly similar to uniprot|Q3E7C1 Saccharomyces cerevisiae YDR079C-A TFB5 Component of the RNA polymerase II general transcription and DNA repair factor TFIIH involved in transcription initiation homolog of the Chlamydomonas reinhardtii REX1-S protein which is involved in DNA repair; TFIIH complex subunit TFB5 1011121 2892593 KLLA0_C11737g Kluyveromyces lactis TFIIH complex subunit TFB5 XP_452724.2 1010903 R 28985 CDS KLLA0_C11759g 2892460 1011298..1013889 C 1 NC_006039.1 similar to uniprot|P38959 Saccharomyces cerevisiae YDR080W VPS41 vacuolar protein sorting component of vacuolar membrane protein complex; uncharacterized protein 1013889 2892460 KLLA0_C11759g Kluyveromyces lactis uncharacterized protein XP_452725.1 1011298 D 28985 CDS KLLA0_C11781g 2892577 complement(1014012..1016309) C 1 NC_006039.1 uniprot|Q01072 Kluyveromyces lactis KLLA0C11781g RAG3 RAG3 protein; uncharacterized protein 1016309 2892577 KLLA0_C11781g Kluyveromyces lactis uncharacterized protein XP_452726.1 1014012 R 28985 CDS KLLA0_C11803g 2892522 complement(1016775..1017212) C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 1017212 2892522 KLLA0_C11803g Kluyveromyces lactis uncharacterized protein XP_452727.1 1016775 R 28985 CDS KLLA0_C11825g 2892521 1017514..1018821 C 1 NC_006039.1 weakly similar to uniprot|P38960 Saccharomyces cerevisiae YDR082W STN1 Protein involved in telomere length regulation functions in telomere metabolism during late S phase; uncharacterized protein 1018821 2892521 KLLA0_C11825g Kluyveromyces lactis uncharacterized protein XP_452728.1 1017514 D 28985 CDS KLLA0_C11847g 2892513 1019168..1020301 C 1 NC_006039.1 similar to uniprot|P38961 Saccharomyces cerevisiae YDR083W RRP8; 25S rRNA (adenine645-N1)-methyltransferase 1020301 2892513 KLLA0_C11847g Kluyveromyces lactis 25S rRNA (adenine645-N1)-methyltransferase XP_452729.1 1019168 D 28985 CDS KLLA0_C11869g 2892511 complement(1020415..1021002) C 1 NC_006039.1 similar to uniprot|P38962 Saccharomyces cerevisiae YDR084C TVP23 Integral membrane protein localized to vesicles along with the v-SNARE Tlg2p green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; uncharacterized protein 1021002 2892511 KLLA0_C11869g Kluyveromyces lactis uncharacterized protein XP_452730.1 1020415 R 28985 CDS KLLA0_C11891g 2892515 complement(1021360..1023213) C 1 NC_006039.1 some similarities with uniprot|P40095 Saccharomyces cerevisiae YER158C; uncharacterized protein 1023213 2892515 KLLA0_C11891g Kluyveromyces lactis uncharacterized protein XP_452731.1 1021360 R 28985 CDS KLLA0_C11913g 2892439 complement(1024233..1025822) C 1 NC_006039.1 similar to gnl|GLV|DEHA0E23727g Debaryomyces hansenii DEHA0E23727g and weakly similar to YHL016C uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane urea transporter expression is highly sensitive to nitrogen catabolite repression and induced by allophanate the last intermediate of the allantoin degradative pathway; uncharacterized protein 1025822 2892439 KLLA0_C11913g Kluyveromyces lactis uncharacterized protein XP_452732.1 1024233 R 28985 CDS KLLA0_C11935g 2892509 complement(1026490..1026942) C 1 NC_006039.1 some similarities with uniprot|P40096 Saccharomyces cerevisiae YER159C BUR6 Protein that forms a heterodimeric histone-fold NC2 general transcription regulator complex with Ydr1p that binds to TBP and represses RNA pol II transcription during assembly of the preinitiation complex homologous to human NC2alpha; negative cofactor 2 transcription regulator complex subunit BUR6 1026942 2892509 KLLA0_C11935g Kluyveromyces lactis negative cofactor 2 transcription regulator complex subunit BUR6 XP_452733.1 1026490 R 28985 CDS KLLA0_C11957g 2892449 complement(1027449..1027661) C 1 NC_006039.1 similar to uniprot|P35179 Saccharomyces cerevisiae YDR086C SSS1 Subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p) involved in transfer of secretory precursors through the endoplasmic reticulum membrane endoplasmic reticulum protein that is part of the Sec61 trimeric complex and the Ssh1 trimeric complex; translocon subunit SSS1 1027661 2892449 KLLA0_C11957g Kluyveromyces lactis translocon subunit SSS1 XP_452734.1 1027449 R 28985 CDS KLLA0_C11979g 2892441 complement(1027919..1028704) C 1 NC_006039.1 similar to uniprot|P35178 Saccharomyces cerevisiae YDR087C RRP1 involved in processing rRNA precursor species to mature rRNAs involved in rRNA processing; uncharacterized protein 1028704 2892441 KLLA0_C11979g Kluyveromyces lactis uncharacterized protein XP_452735.1 1027919 R 28985 CDS KLLA0_C12001g 2892442 complement(1029092..1029871) C 1 NC_006039.1 similar to uniprot|P13856 Saccharomyces cerevisiae YGR152C RSR1 GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases; Ras family GTPase RSR1 1029871 2892442 KLLA0_C12001g Kluyveromyces lactis Ras family GTPase RSR1 XP_452736.1 1029092 R 28985 CDS KLLA0_C12023g 2892466 1030677..1031300 C 1 NC_006039.1 similar to uniprot|Q754A8 Ashbya gossypii AFR164W AFR164Wp and some similarites with YGL105W uniprot|P46672 Saccharomyces cerevisiae YGL105W ARC1 Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p) delivering tRNA to them stimulating catalysis and ensuring their localization to the cytoplasm also binds quadruplex nucleic acids; uncharacterized protein 1031300 2892466 KLLA0_C12023g Kluyveromyces lactis uncharacterized protein XP_452737.1 1030677 D 28985 CDS KLLA0_C12034g 9487432 complement(1031339..1031578) C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 1031578 9487432 KLLA0_C12034g Kluyveromyces lactis uncharacterized protein XP_002999359.1 1031339 R 28985 CDS KLLA0_C12111g 2891944 1032731..1033771 C 1 NC_006039.1 similar to uniprot|Q12239 Saccharomyces cerevisiae YOL107W Hypothetical ORF; uncharacterized protein 1033771 2891944 KLLA0_C12111g Kluyveromyces lactis uncharacterized protein XP_452738.1 1032731 D 28985 CDS KLLA0_C12133g 2891980 complement(1033945..1034874) C 1 NC_006039.1 similar to uniprot|P36520 Saccharomyces cerevisiae YNL284C MRPL10 Mitochondrial ribosomal protein of the large subunit appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels; mitochondrial 54S ribosomal protein uL15m 1034874 2891980 KLLA0_C12133g Kluyveromyces lactis mitochondrial 54S ribosomal protein uL15m XP_452739.1 1033945 R 28985 CDS KLLA0_C12177g 2892475 complement(1035757..1037028) C 1 NC_006039.1 some similarities with uniprot|Q12215 Saccharomyces cerevisiae YOL105C WSC3 cell wall integrity and stress response component 3 Putative integral membrane protein containing novel cysteine motif; uncharacterized protein 1037028 2892475 KLLA0_C12177g Kluyveromyces lactis uncharacterized protein XP_452740.1 1035757 R 28985 CDS KLLA0_C12199g 2892490 1037929..1038525 C 1 NC_006039.1 similar to uniprot|P53833 Saccharomyces cerevisiae YNL282W POP3 Subunit of both RNase MRP which cleaves pre-rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends; uncharacterized protein 1038525 2892490 KLLA0_C12199g Kluyveromyces lactis uncharacterized protein XP_452741.1 1037929 D 28985 CDS KLLA0_C12221g 2892446 1038876..1039304 C 1 NC_006039.1 similar to uniprot|P53834 Saccharomyces cerevisiae YNL281W HCH1 Heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation GFP-fusion protein localizes to the cytoplasm and nucleus; uncharacterized protein 1039304 2892446 KLLA0_C12221g Kluyveromyces lactis uncharacterized protein XP_452742.1 1038876 D 28985 CDS KLLA0_C12243g 2892493 1039717..1041024 C 1 NC_006039.1 weakly similar to uniprot|P53304 Saccharomyces cerevisiae YGR212W SLI1 N-acetyltransferase confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by inactivating it co-operates with Ypk1p in mediating resistance to myriocin converts myriocin into N-acetyl-myriocin; N-acetyltransferase 1041024 2892493 KLLA0_C12243g Kluyveromyces lactis N-acetyltransferase XP_452743.1 1039717 D 28985 CDS KLLA0_C12265g 2892474 complement(1041161..1042486) C 1 NC_006039.1 similar to uniprot|P32462 Saccharomyces cerevisiae YNL280C ERG24 C-14 sterol reductase acts in ergosterol biosynthesis mutants accumulate the abnormal sterol ignosterol (ergosta-8 14 dienol) and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions; delta(14)-sterol reductase 1042486 2892474 KLLA0_C12265g Kluyveromyces lactis delta(14)-sterol reductase XP_452744.1 1041161 R 28985 CDS KLLA0_C12287g 2892497 complement(1042861..1043847) C 1 NC_006039.1 weakly similar to uniprot|Q12366 Saccharomyces cerevisiae YOL104C NDJ1 Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution (interference), sister chromatid cohesion at meiotic telomeres, and segregation of small chromosomes; uncharacterized protein 1043847 2892497 KLLA0_C12287g Kluyveromyces lactis uncharacterized protein XP_452745.1 1042861 R 28985 CDS KLLA0_C12300g 2892462 1044346..1045434 C 1 NC_006039.1 weakly similar to uniprot|P28791 Saccharomyces cerevisiae YDR498C SEC20 Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER required for N- and O-glycosylation in the Golgi but not in the ER forms a complex with the cytosolic Tip20p; uncharacterized protein 1045434 2892462 KLLA0_C12300g Kluyveromyces lactis uncharacterized protein XP_452746.2 1044346 D 28985 CDS KLLA0_C12309g 2892487 1046848..1048557 C 1 NC_006039.1 highly similar to uniprot|P30606 Saccharomyces cerevisiae YOL103W ITR2 Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively; myo-inositol transporter ITR1 1048557 2892487 KLLA0_C12309g Kluyveromyces lactis myo-inositol transporter ITR1 XP_452747.1 1046848 D 28985 CDS KLLA0_C12331g 2892666 1049113..1051101 C 1 NC_006039.1 similar to uniprot|Q04373 YDR496C Saccharomyces cerevisiae PUF6 Pumilio-homology domain protein that binds ASH1 mRNA at PUF consensus sequences; pumilio-family RNA binding domain-containing protein 1051101 2892666 KLLA0_C12331g Kluyveromyces lactis pumilio-family RNA binding domain-containing protein XP_452748.1 1049113 D 28985 CDS KLLA0_C12353g 2892573 1051312..1053930 C 1 NC_006039.1 weakly similar to uniprot|P23643 Saccharomyces cerevisiae YDR495C VPS3 Vacuolar sorting protein; CORVET complex subunit VPS3 1053930 2892573 KLLA0_C12353g Kluyveromyces lactis CORVET complex subunit VPS3 XP_452749.1 1051312 D 28985 CDS KLLA0_C12375g 2892557 complement(1054019..1055032) C 1 NC_006039.1 weakly similar to uniprot|Q8X185 Saccharomyces cerevisiae YDR494W RSM28 Mitochondrial ribosomal protein of the small subunit genetic interactions suggest a possible role in promoting translation initiation; uncharacterized protein 1055032 2892557 KLLA0_C12375g Kluyveromyces lactis uncharacterized protein XP_452750.1 1054019 R 28985 CDS KLLA0_C12397g 2892554 complement(1055443..1056153) C 1 NC_006039.1 similar to uniprot|Q12272 YOL102C Saccharomyces cerevisiae TPT1 tRNA 2'-phosphotransferase; tRNA 2'-phosphotransferase 1056153 2892554 KLLA0_C12397g Kluyveromyces lactis tRNA 2'-phosphotransferase XP_452751.1 1055443 R 28985 CDS KLLA0_C12419g 2892416 complement(1056703..1057050) C 1 NC_006039.1 similar to uniprot|Q03429 YDR493W Saccharomyces cerevisiae YDR493W FMP36; uncharacterized protein 1057050 2892416 KLLA0_C12419g Kluyveromyces lactis uncharacterized protein XP_452752.1 1056703 R 28985 CDS KLLA0_C12441g 2892419 complement(1057427..1058374) C 1 NC_006039.1 similar to uniprot|Q6Q557 Saccharomyces cerevisiae YDR492W IZH1 Membrane protein involved in zinc metabolism member of the four-protein IZH family transcription is regulated directly by Zap1p expression induced by zinc deficiency and fatty acids deletion increases sensitivity to elevated zinc; PAQR-type receptor 1058374 2892419 KLLA0_C12441g Kluyveromyces lactis PAQR-type receptor XP_452753.1 1057427 R 28985 CDS KLLA0_C12463g 2892408 complement(1058741..1059361) C 1 NC_006039.1 no similarity; uncharacterized protein 1059361 2892408 KLLA0_C12463g Kluyveromyces lactis uncharacterized protein XP_452754.1 1058741 R 28985 CDS KLLA0_C12485g 2892423 1060167..1062944 C 1 NC_006039.1 similar to uniprot|Q12236 YOL100W Saccharomyces cerevisiae YOL100W PKH2 Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; serine/threonine protein kinase PKH1 1062944 2892423 KLLA0_C12485g Kluyveromyces lactis serine/threonine protein kinase PKH1 XP_452755.1 1060167 D 28985 CDS KLLA0_C12507g 2892122 complement(join(1063093..1064427,1064541..1064570)) C 1 NC_006039.1 similar to uniprot|Q05123 Saccharomyces cerevisiae YMR033W ARP9 Actin-related protein involved in transcriptional regulation; subunit of the chromatin remodeling Snf/Swi complex; uncharacterized protein 1064570 2892122 KLLA0_C12507g Kluyveromyces lactis uncharacterized protein XP_452756.1 1063093 R 28985 CDS KLLA0_C12529g 2891972 1064844..1065398 C 1 NC_006039.1 highly similar to uniprot|P36012 Saccharomyces cerevisiae YKL049C CSE4 Centromere protein that resembles histones required for proper kinetochore function homolog of human CENP-A; centromeric DNA-binding histone H3-like protein CSE4 1065398 2891972 KLLA0_C12529g Kluyveromyces lactis centromeric DNA-binding histone H3-like protein CSE4 XP_452757.1 1064844 D 28985 CDS KLLA0_C12551g 2892632 complement(1065593..1067416) C 1 NC_006039.1 weakly similar to uniprot|Q05080 Saccharomyces cerevisiae YMR032W HOF1 Bud neck-localized SH3 domain-containing protein required for cytokinesis; formin-binding protein HOF1 1067416 2892632 KLLA0_C12551g Kluyveromyces lactis formin-binding protein HOF1 XP_452758.1 1065593 R 28985 CDS KLLA0_C12573g 2892410 1068765..1071257 C 1 NC_006039.1 similar to uniprot|Q05050 Saccharomyces cerevisiae YMR031C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; uncharacterized protein 1071257 2892410 KLLA0_C12573g Kluyveromyces lactis uncharacterized protein XP_452759.1 1068765 D 28985 CDS KLLA0_C12595g 2892588 complement(1071642..1072568) C 1 NC_006039.1 similar to uniprot|P35735 Saccharomyces cerevisiae YKL051W; uncharacterized protein 1072568 2892588 KLLA0_C12595g Kluyveromyces lactis uncharacterized protein XP_452760.1 1071642 R 28985 CDS KLLA0_C12617g 2892639 1073463..1074119 C 1 NC_006039.1 some similarities with uniprot|P35734 Saccharomyces cerevisiae YKL052C ASK1 Component of the DASH complex that binds to microtubules and kinetochores and is essential for chromosome segregation phosphorylated during the cell cycle by cyclin-dependent kinases; uncharacterized protein 1074119 2892639 KLLA0_C12617g Kluyveromyces lactis uncharacterized protein XP_452761.1 1073463 D 28985 CDS KLLA0_C12639g 2892612 1074370..1074624 C 1 NC_006039.1 highly similar to uniprot|O60200 Saccharomyces cerevisiae YKL053C-A MDM35 Mitochondrial Distribution and Morphology; uncharacterized protein 1074624 2892612 KLLA0_C12639g Kluyveromyces lactis uncharacterized protein XP_452763.1 1074370 D 28985 CDS KLLA0_C12672g 2892415 1075548..1077485 C 1 NC_006039.1 some similarities with uniprot|P35732 Saccharomyces cerevisiae YKL054C DEF1 RNAPII degradation factor forms a complex with Rad26p in chromatin enables ubiquitination and proteolysis of RNAPII; DNA damage-responsive RNA polymerase-degradation factor DEF1 1077485 2892415 KLLA0_C12672g Kluyveromyces lactis DNA damage-responsive RNA polymerase-degradation factor DEF1 XP_452764.1 1075548 D 28985 CDS KLLA0_C12694g 2892469 1077786..1078565 C 1 NC_006039.1 similar to uniprot|P35731 Saccharomyces cerevisiae YKL055C OAR1 Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase may comprise a type II mitochondrial fatty acid synthase along with Mct1p; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) 1078565 2892469 KLLA0_C12694g Kluyveromyces lactis 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) XP_452765.1 1077786 D 28985 CDS KLLA0_C12716g 2892417 1079048..1079551 C 1 NC_006039.1 highly similar to uniprot|P35691 Saccharomyces cerevisiae YKL056C RBF18 Hypothetical ORF; uncharacterized protein 1079551 2892417 KLLA0_C12716g Kluyveromyces lactis uncharacterized protein XP_452766.1 1079048 D 28985 CDS KLLA0_C12749g 2892414 1079939..1081603 C 1 NC_006039.1 similar to uniprot|Q05040 Saccharomyces cerevisiae YMR029C FAR8 Protein involved in G1 cell cycle arrest in response to pheromone in a pathway different from the Far1p-dependent pathway interacts with Far3p Far7p Far9p Far10p and Far11p; uncharacterized protein 1081603 2892414 KLLA0_C12749g Kluyveromyces lactis uncharacterized protein XP_452768.1 1079939 D 28985 CDS KLLA0_C12771g 2891916 1081988..1085017 C 1 NC_006039.1 similar to uniprot|P35729 Saccharomyces cerevisiae YKL057C NUP120 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) required for even distribution of NPCs around the nuclear envelope involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; uncharacterized protein 1085017 2891916 KLLA0_C12771g Kluyveromyces lactis uncharacterized protein XP_452769.1 1081988 D 28985 CDS KLLA0_C12793g 2892013 complement(1085044..1086129) C 1 NC_006039.1 similar to uniprot|Q04372 Saccharomyces cerevisiae YMR028W TAP42 Protein that physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits; uncharacterized protein 1086129 2892013 KLLA0_C12793g Kluyveromyces lactis uncharacterized protein XP_452770.1 1085044 R 28985 CDS KLLA0_C12815g 2892597 complement(1086418..1086759) C 1 NC_006039.1 similar to uniprot|P32774 Saccharomyces cerevisiae YKL058W TOA2 Transcription factor IIA small chain; transcription initiation factor IIA subunit gamma 1086759 2892597 KLLA0_C12815g Kluyveromyces lactis transcription initiation factor IIA subunit gamma XP_452771.1 1086418 R 28985 CDS KLLA0_C12837g 2892406 1087043..1088317 C 1 NC_006039.1 similar to uniprot|P35728 Saccharomyces cerevisiae YKL059C MPE1 Essential conserved subunit of CPF (cleavage and polyadenylation factor) plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA contains a putative RNA-binding zinc knuckle motif; cleavage polyadenylation factor subunit MPE1 1088317 2892406 KLLA0_C12837g Kluyveromyces lactis cleavage polyadenylation factor subunit MPE1 XP_452772.1 1087043 D 28985 CDS KLLA0_C12859g 2892503 complement(1088553..1089890) C 1 NC_006039.1 similar to uniprot|Q04371 Saccharomyces cerevisiae YMR027W High level expression reduced Ty3 Transposition; uncharacterized protein 1089890 2892503 KLLA0_C12859g Kluyveromyces lactis uncharacterized protein XP_452773.1 1088553 R 28985 CDS KLLA0_C12881g 2892424 1090895..1092016 C 1 NC_006039.1 similar to uniprot|P48559 Saccharomyces cerevisiae YNL304W YPT11 Rab-type small GTPase that interacts with the C-terminal tail domain of Myo2p to mediate distribution of mitochondria to daughter cells; Rab family GTPase YPT11 1092016 2892424 KLLA0_C12881g Kluyveromyces lactis Rab family GTPase YPT11 XP_452774.1 1090895 D 28985 CDS KLLA0_C12903g 2892672 complement(1092251..1093564) C 1 NC_006039.1 similar to uniprot|Q12463 Saccharomyces cerevisiae YOL124C Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; tRNA (guanine-N2-)-methyltransferase 1093564 2892672 KLLA0_C12903g Kluyveromyces lactis tRNA (guanine-N2-)-methyltransferase XP_452775.1 1092251 R 28985 CDS KLLA0_C12925g 2892458 1094574..1096286 C 1 NC_006039.1 weakly similar to uniprot|Q99383 Saccharomyces cerevisiae YOL123W HRP1 Subunit of cleavage factor I a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences; uncharacterized protein 1096286 2892458 KLLA0_C12925g Kluyveromyces lactis uncharacterized protein XP_452776.1 1094574 D 28985 CDS KLLA0_C12947g 2892110 1096922..1098139 C 1 NC_006039.1 similar to uniprot|P39727 Saccharomyces cerevisiae YAL042W ERV46 Protein localized to COPII-coated vesicles forms a complex with Erv41p involved in the membrane fusion stage of transport; uncharacterized protein 1098139 2892110 KLLA0_C12947g Kluyveromyces lactis uncharacterized protein XP_452777.1 1096922 D 28985 CDS KLLA0_C12969g 2892202 1098631..1100904 C 1 NC_006039.1 similar to uniprot|P11433 Saccharomyces cerevisiae YAL041W CDC24 Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p required for polarity establishment and maintenance and mutants have morphological defects in bud formation and shmooing; Rho family guanine nucleotide exchange factor CDC24 1100904 2892202 KLLA0_C12969g Kluyveromyces lactis Rho family guanine nucleotide exchange factor CDC24 XP_452778.1 1098631 D 28985 CDS KLLA0_C12991g 2891949 complement(1101129..1103114) C 1 NC_006039.1 similar to uniprot|Q08822 Saccharomyces cerevisiae YOR356W Hypothetical ORF; uncharacterized protein 1103114 2891949 KLLA0_C12991g Kluyveromyces lactis uncharacterized protein XP_452779.1 1101129 R 28985 CDS KLLA0_C13013g 2891974 complement(1103930..1105315) C 1 NC_006039.1 similar to uniprot|P41913 Saccharomyces cerevisiae YOR355W GDS1 Protein of unknown function required for growth on glycerol as a carbon source; uncharacterized protein 1105315 2891974 KLLA0_C13013g Kluyveromyces lactis uncharacterized protein XP_452780.1 1103930 R 28985 CDS KLLA0_C13035g 2891930 complement(1106439..1108007) C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 1108007 2891930 KLLA0_C13035g Kluyveromyces lactis uncharacterized protein XP_452781.1 1106439 R 28985 CDS KLLA0_C13057g 2891919 complement(1109343..1110593) C 1 NC_006039.1 some similarities with uniprot|P13365 Saccharomyces cerevisiae YAL040C CLN3 role in cell cycle START involved in G(sub)1 size control G(sub)1 cyclin; cyclin CLN3 1110593 2891919 KLLA0_C13057g Kluyveromyces lactis cyclin CLN3 XP_452782.1 1109343 R 28985 CDS KLLA0_C13079g 2892611 complement(1113707..1114108) C 1 NC_006039.1 no similarity; uncharacterized protein 1114108 2892611 KLLA0_C13079g Kluyveromyces lactis uncharacterized protein XP_452783.1 1113707 R 28985 CDS KLLA0_C13101g 2891838 1115573..1117699 C 1 NC_006039.1 weakly similar to uniprot|Q08818 Saccharomyces cerevisiae YOR354C MSC6 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to mitochondria msc6 mutants are defective in directing meiotic recombination events to homologous chromatids; uncharacterized protein 1117699 2891838 KLLA0_C13101g Kluyveromyces lactis uncharacterized protein XP_452784.1 1115573 D 28985 CDS KLLA0_C13123g 2892479 complement(1118007..1118969) C 1 NC_006039.1 similar to uniprot|P06182 Saccharomyces cerevisiae YAL039C CYC3 Cytochrome c heme lyase (holocytochrome c synthase) attaches heme to apo-Cyc1p in the mitochondrial intermembrane space human ortholog may have a role in microphthalmia with linear skin defects (MLS); holocytochrome c synthase CYC3 1118969 2892479 KLLA0_C13123g Kluyveromyces lactis holocytochrome c synthase CYC3 XP_452785.1 1118007 R 28985 CDS KLLA0_C13145g 2892190 1119411..1121789 C 1 NC_006039.1 similar to uniprot|Q08817 Saccharomyces cerevisiae YOR353C SOG2 Protein required for cell viability; uncharacterized protein 1121789 2892190 KLLA0_C13145g Kluyveromyces lactis uncharacterized protein XP_452786.1 1119411 D 28985 CDS KLLA0_C13167g 2892582 complement(1121827..1122846) C 1 NC_006039.1 weakly similar to uniprot|Q08816 Saccharomyces cerevisiae YOR352W Hypothetical ORF; TFIIH complex subunit TFB6 1122846 2892582 KLLA0_C13167g Kluyveromyces lactis TFIIH complex subunit TFB6 XP_452787.1 1121827 R 28985 CDS KLLA0_C13189g 2892589 complement(1123917..1124930) C 1 NC_006039.1 some similarities with uniprot|Q99188 Saccharomyces cerevisiae YOR107W RGS2 Negative regulator of glucose-induced cAMP signaling directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p; uncharacterized protein 1124930 2892589 KLLA0_C13189g Kluyveromyces lactis uncharacterized protein XP_452788.1 1123917 R 28985 CDS KLLA0_C13211g 2892482 1126739..1128868 C 1 NC_006039.1 weakly similar to uniprot|P32389 Saccharomyces cerevisiae YNL103W MET4 Lecine-zipper transcriptional activator responsible for the regulation of the sulfur amino acid pathway requires different combinations of the auxiliary factors Cbf1p Met28p Met31p and Met32p; uncharacterized protein 1128868 2892482 KLLA0_C13211g Kluyveromyces lactis uncharacterized protein XP_452789.1 1126739 D 28985 CDS KLLA0_C13233g 2891892 complement(1129020..1129808) C 1 NC_006039.1 similar to uniprot|Q12241 Saccharomyces cerevisiae YOR106W VAM3 Syntaxin-related protein required for vacuolar assembly PEP12 homolog; SNAP receptor VAM3 1129808 2891892 KLLA0_C13233g Kluyveromyces lactis SNAP receptor VAM3 XP_452790.1 1129020 R 28985 CDS KLLA0_C13255g 2892012 1130329..1134621 C 1 NC_006039.1 similar to uniprot|P13382 Saccharomyces cerevisiae YNL102W POL1 Catalytic subunit of the DNA polymerase alpha-primase complex required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis; DNA-directed DNA polymerase alpha catalytic subunit POL1 1134621 2892012 KLLA0_C13255g Kluyveromyces lactis DNA-directed DNA polymerase alpha catalytic subunit POL1 XP_452791.1 1130329 D 28985 CDS KLLA0_C13277g 2892614 1135255..1137420 C 1 NC_006039.1 similar to uniprot|P50944 Saccharomyces cerevisiae YNL101W AVT4 Vacuolar transporter exports large neutral amino acids from the vacuole member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; uncharacterized protein 1137420 2892614 KLLA0_C13277g Kluyveromyces lactis uncharacterized protein XP_452792.1 1135255 D 28985 CDS KLLA0_C13299g 2891998 1137783..1138505 C 1 NC_006039.1 similar to uniprot|P50945 Saccharomyces cerevisiae YNL100W Hypothetical ORF; uncharacterized protein 1138505 2891998 KLLA0_C13299g Kluyveromyces lactis uncharacterized protein XP_452793.1 1137783 D 28985 CDS KLLA0_C13321g 2891934 complement(1138666..1139406) C 1 NC_006039.1 weakly similar to uniprot|Q12057 Saccharomyces cerevisiae YOR104W PIN2 Protein that induces appearance of [PIN ] prion when overproduced; uncharacterized protein 1139406 2891934 KLLA0_C13321g Kluyveromyces lactis uncharacterized protein XP_452794.1 1138666 R 28985 CDS KLLA0_C13343g 2891920 complement(1139922..1140554) C 1 NC_006039.1 highly similar to uniprot|P50946 Saccharomyces cerevisiae YNL099C OCA1 Putative protein tyrosine phosphatase required for cell cycle arrest in response to oxidative damage of DNA; uncharacterized protein 1140554 2891920 KLLA0_C13343g Kluyveromyces lactis uncharacterized protein XP_452795.1 1139922 R 28985 CDS KLLA0_C13365g 2892002 1140975..1141355 C 1 NC_006039.1 similar to uniprot|P46964 Saccharomyces cerevisiae YOR103C OST2 Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen which catalyzes asparagine-linked glycosylation of newly synthesized proteins; dolichyl-diphosphooligosaccharide-protein glycotransferase 1141355 2892002 KLLA0_C13365g Kluyveromyces lactis dolichyl-diphosphooligosaccharide-protein glycotransferase XP_452796.1 1140975 D 28985 CDS KLLA0_C13387g 2891922 complement(join(1142002..1142841,1143162..1143176)) C 1 NC_006039.1 similar to uniprot|P01120 Saccharomyces cerevisiae YNL098C RAS2 GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes; Ras family GTPase RAS1 1143176 2891922 KLLA0_C13387g Kluyveromyces lactis Ras family GTPase RAS1 XP_452797.2 1142002 R 28985 CDS KLLA0_C13409g 2892440 complement(1143660..1144835) C 1 NC_006039.1 some similarities with uniprot|P50947 Saccharomyces cerevisiae YNL097C; uncharacterized protein 1144835 2892440 KLLA0_C13409g Kluyveromyces lactis uncharacterized protein XP_452798.1 1143660 R 28985 CDS KLLA0_C13431g 2892598 1145919..1146905 C 1 NC_006039.1 similar to uniprot|Q12289 Saccharomyces cerevisiae YOR100C CRC1 Mitochondrial inner membrane carnitine transporter required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta- oxidation; carnitine:acyl carnitine antiporter 1146905 2892598 KLLA0_C13431g Kluyveromyces lactis carnitine:acyl carnitine antiporter XP_452799.1 1145919 D 28985 CDS KLLA0_C13453g 2891950 complement(1147145..1148365) C 1 NC_006039.1 similar to uniprot|P27810 Saccharomyces cerevisiae YOR099W KTR1 Alpha-1 2-mannosyltransferase involved in O-and N-linked protein glycosylation member of the KRE2/MNT1 mannosyltransferase family; alpha-1,2-mannosyltransferase KTR1 1148365 2891950 KLLA0_C13453g Kluyveromyces lactis alpha-1,2-mannosyltransferase KTR1 XP_452800.1 1147145 R 28985 CDS KLLA0_C13475g 2892393 1149711..1152434 C 1 NC_006039.1 weakly similar to uniprot|P20676 Saccharomyces cerevisiae YOR098C NUP1 Nuclear pore complex (NPC) subunit involved in protein import/export and in export of RNAs possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC potential Cdc28p substrate; FG-nucleoporin NUP1 1152434 2892393 KLLA0_C13475g Kluyveromyces lactis FG-nucleoporin NUP1 XP_452801.1 1149711 D 28985 CDS KLLA0_C13497g 2892183 1152917..1153396 C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 1153396 2892183 KLLA0_C13497g Kluyveromyces lactis uncharacterized protein XP_452802.1 1152917 D 28985 CDS KLLA0_C13519g 2892362 complement(join(1153725..1154153,1154665..1154808)) C 1 NC_006039.1 highly similar to uniprot|P26786 Saccharomyces cerevisiae YOR096W; 40S ribosomal protein eS7 1154808 2892362 KLLA0_C13519g Kluyveromyces lactis 40S ribosomal protein eS7 XP_452803.1 1153725 R 28985 CDS KLLA0_C13541g 2892283 1155897..1156721 C 1 NC_006039.1 similar to uniprot|Q12189 Saccharomyces cerevisiae YOR095C RKI1 Ribose-5-phosphate ketol-isomerase; ribose-5-phosphate isomerase RKI1 1156721 2892283 KLLA0_C13541g Kluyveromyces lactis ribose-5-phosphate isomerase RKI1 XP_452804.1 1155897 D 28985 CDS KLLA0_C13563g 2892378 complement(1157278..1157826) C 1 NC_006039.1 highly similar to uniprot|P40994 Saccharomyces cerevisiae YOR094W ARF3 Glucose-repressible ADP-ribosylation factor GTPase of the Ras superfamily involved in development of polarity; Arf family GTPase ARF3 1157826 2892378 KLLA0_C13563g Kluyveromyces lactis Arf family GTPase ARF3 XP_452805.1 1157278 R 28985 CDS KLLA0_C13585g 2892591 1159397..1164289 C 1 NC_006039.1 similar to uniprot|Q12275 Saccharomyces cerevisiae YOR093C Hypothetical ORF; uncharacterized protein 1164289 2892591 KLLA0_C13585g Kluyveromyces lactis uncharacterized protein XP_452806.1 1159397 D 28985 CDS KLLA0_C13607g 2892445 complement(1164479..1166092) C 1 NC_006039.1 similar to gnl|GLV|CAGL0G06468g Candida glabrata CAGL0G06468g and some similarites with YOR092W uniprot|Q99252 Saccharomyces cerevisiae YOR092W ECM3 Non-essential protein of unknown function; uncharacterized protein 1166092 2892445 KLLA0_C13607g Kluyveromyces lactis uncharacterized protein XP_452807.1 1164479 R 28985 CDS KLLA0_C13651g 2892504 1167624..1169333 C 1 NC_006039.1 similar to uniprot|Q75CK0 Ashbya gossypii ACL081C ACL081Cp and weakly similar to YNL094W uniprot|P53933 Saccharomyces cerevisiae YNL094W APP1 Protein of unknown function interacts with Rvs161p and Rvs167p computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization; phosphatidate phosphatase APP1 1169333 2892504 KLLA0_C13651g Kluyveromyces lactis phosphatidate phosphatase APP1 XP_452809.1 1167624 D 28985 CDS KLLA0_C13673g 2892033 complement(1169503..1170546) C 1 NC_006039.1 similar to uniprot|Q12000 Saccharomyces cerevisiae YOR091W RBF46 Hypothetical ORF; uncharacterized protein 1170546 2892033 KLLA0_C13673g Kluyveromyces lactis uncharacterized protein XP_452810.1 1169503 R 28985 CDS KLLA0_C13706g 2891835 1171272..1172918 C 1 NC_006039.1 similar to uniprot|Q12511 Saccharomyces cerevisiae YOR090C PTC5 Mitochondrially localized type 2C protein phosphatase contains Mg2 /Mn2 -dependent casein phosphatase activity in vitro but in vivo substrates are unknown; type 2C protein phosphatase PTC5 1172918 2891835 KLLA0_C13706g Kluyveromyces lactis type 2C protein phosphatase PTC5 XP_452812.1 1171272 D 28985 CDS KLLA0_C13728g 2892401 1173329..1173955 C 1 NC_006039.1 highly similar to uniprot|P36017 Saccharomyces cerevisiae YOR089C VPS21 Rab5-like GTPase involved in vacuolar protein sorting and endocytosis post vesicle internalization geranylgeranylated geranylgeranylation required for membrane association; Rab family GTPase VPS21 1173955 2892401 KLLA0_C13728g Kluyveromyces lactis Rab family GTPase VPS21 XP_452813.1 1173329 D 28985 CDS KLLA0_C13750g 2892315 1174325..1175512 C 1 NC_006039.1 similar to uniprot|P53934 Saccharomyces cerevisiae YNL092W Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; S-adenosylmethionine-dependent methyltransferase 1175512 2892315 KLLA0_C13750g Kluyveromyces lactis S-adenosylmethionine-dependent methyltransferase XP_452814.1 1174325 D 28985 CDS KLLA0_C13772g 2892628 complement(1175544..1177574) C 1 NC_006039.1 similar to uniprot|Q12324 Saccharomyces cerevisiae YOR088W/YOR087W YVC1 Vacuolar cation channel; uncharacterized protein 1177574 2892628 KLLA0_C13772g Kluyveromyces lactis uncharacterized protein XP_452815.1 1175544 R 28985 CDS KLLA0_C13794g 2892329 1178848..1182747 C 1 NC_006039.1 some similarities with uniprot|P53935 Saccharomyces cerevisiae YNL091W NST1 Protein of unknown function mediates sensitivity to salt stress interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1; uncharacterized protein 1182747 2892329 KLLA0_C13794g Kluyveromyces lactis uncharacterized protein XP_452816.1 1178848 D 28985 CDS KLLA0_C13816g 2892685 1183412..1183975 C 1 NC_006039.1 highly similar to uniprot|P06781 Saccharomyces cerevisiae YNL090W RHO2 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity and in microtubule assembly; Rho family GTPase RHO2 1183975 2892685 KLLA0_C13816g Kluyveromyces lactis Rho family GTPase RHO2 XP_452817.1 1183412 D 28985 CDS KLLA0_C13838g 2892516 1184534..1188841 C 1 NC_006039.1 similar to uniprot|P06786 Saccharomyces cerevisiae YNL088W TOP2 Essential type II topoisomerase catalyzes topology changes in DNA via transient breakage and rejoining of phosphodiester bonds in the DNA backbone localizes to axial cores in meiosis; DNA topoisomerase 2 1188841 2892516 KLLA0_C13838g Kluyveromyces lactis DNA topoisomerase 2 XP_452818.1 1184534 D 28985 CDS KLLA0_C13860g 2892514 1189822..1193343 C 1 NC_006039.1 similar to uniprot|Q12466 Saccharomyces cerevisiae YOR086C TCB1 Contains three calcium and lipid binding domains green fluorescent protein (GFP)-fusion protein localizes to the cell periphery C-terminal portion of Tcb1p Tcb2p and Tcb3p interact; tricalbin 1193343 2892514 KLLA0_C13860g Kluyveromyces lactis tricalbin XP_452819.1 1189822 D 28985 CDS KLLA0_C13882g 2892453 1193639..1193938 C 1 NC_006039.1 similar to uniprot|P48232 Saccharomyces cerevisiae YNL086W Hypothetical ORF; uncharacterized protein 1193938 2892453 KLLA0_C13882g Kluyveromyces lactis uncharacterized protein XP_452820.1 1193639 D 28985 CDS KLLA0_C13904g 2892398 complement(1194035..1195072) C 1 NC_006039.1 similar to uniprot|P48439 Saccharomyces cerevisiae YOR085W OST3 Gamma subunit of the oligosaccharyltransferase complex of the ER lumen which catalyzes asparagine-linked glycosylation of newly synthesized proteins Ost3p is important for N- glycosylation of a subset of proteins; dolichyl-diphosphooligosaccharide--protein glycotransferase OST3 1195072 2892398 KLLA0_C13904g Kluyveromyces lactis dolichyl-diphosphooligosaccharide--protein glycotransferase OST3 XP_452821.1 1194035 R 28985 CDS KLLA0_C13926g 2892520 1195709..1198063 C 1 NC_006039.1 similar to uniprot|P40850 Saccharomyces cerevisiae YNL085W MKT1 Protein involved in propagation of M2 dsRNA satellite of L-A virus forms a complex with Pbp1p that is involved in posttranscriptional regulation of HO endonuclease; uncharacterized protein 1198063 2892520 KLLA0_C13926g Kluyveromyces lactis uncharacterized protein XP_452822.1 1195709 D 28985 CDS KLLA0_C13948g 2892450 complement(1198406..1200832) C 1 NC_006039.1 similar to uniprot|P32843 Saccharomyces cerevisiae YMR302C PRP12 Integral inner mitochondrial membrane protein with similarity to exonucleases; uncharacterized protein 1200832 2892450 KLLA0_C13948g Kluyveromyces lactis uncharacterized protein XP_452823.1 1198406 R 28985 CDS KLLA0_C14003g 2892602 complement(1204999..1205868) C 1 NC_006039.1 similar to uniprot|P53332 Saccharomyces cerevisiae YGR277C Homolog to human PPAT; uncharacterized protein 1205868 2892602 KLLA0_C14003g Kluyveromyces lactis uncharacterized protein XP_452826.1 1204999 R 28985 CDS KLLA0_C14025g 2892596 1206080..1207669 C 1 NC_006039.1 weakly similar to uniprot|P53333 Saccharomyces cerevisiae YGR278W CWC22 Essential protein component of a complex containing Cef1p has similarity to S. pombe Cwf22p putative spliceosomal component based on computational analysis of large-scale protein-protein interaction data; U2-type spliceosomal complex subunit CWC22 1207669 2892596 KLLA0_C14025g Kluyveromyces lactis U2-type spliceosomal complex subunit CWC22 XP_452827.1 1206080 D 28985 CDS KLLA0_C14047g 2891902 complement(1208373..1209509) C 1 NC_006039.1 similar to uniprot|P53334 Saccharomyces cerevisiae YGR279C; uncharacterized protein 1209509 2891902 KLLA0_C14047g Kluyveromyces lactis uncharacterized protein XP_452828.1 1208373 R 28985 CDS KLLA0_C14069g 2892023 1211025..1216310 C 1 NC_006039.1 similar to uniprot|P40989 Saccharomyces cerevisiae YGR032W GSC2 or uniprot|P38631 Saccharomyces cerevisiae YLR342W FKS1 or uniprot|Q04952 Saccharomyces cerevisiae YMR306W FKS3; uncharacterized protein 1216310 2892023 KLLA0_C14069g Kluyveromyces lactis uncharacterized protein XP_452829.1 1211025 D 28985 CDS KLLA0_C14091g 2892386 1217374..1219041 C 1 NC_006039.1 similar to uniprot|P22146 Saccharomyces cerevisiae YMR307W GAS1 Beta-1.3-glucanosyltransferase required for cell wall assembly localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; 1,3-beta-glucanosyltransferase GAS1 1219041 2892386 KLLA0_C14091g Kluyveromyces lactis 1,3-beta-glucanosyltransferase GAS1 XP_452830.1 1217374 D 28985 CDS KLLA0_C14113g 2892599 1220244..1221869 C 1 NC_006039.1 similar to uniprot|P22146 Saccharomyces cerevisiae YMR307W GAS1 Beta-1.3-glucanosyltransferase required for cell wall assembly localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; uncharacterized protein 1221869 2892599 KLLA0_C14113g Kluyveromyces lactis uncharacterized protein XP_452831.1 1220244 D 28985 CDS KLLA0_C14135g 2892366 complement(1221902..1222717) C 1 NC_006039.1 similar to uniprot|P53335 Saccharomyces cerevisiae YGR280C PXR1 Protein with a role in maturation of rRNAs and small nucleolar RNAs required for cell viability; telomerase inhibitor 1222717 2892366 KLLA0_C14135g Kluyveromyces lactis telomerase inhibitor XP_452832.1 1221902 R 28985 CDS KLLA0_C14157g 2892375 complement(1223130..1226402) C 1 NC_006039.1 similar to uniprot|P32337 Saccharomyces cerevisiae YMR308C PSE1 Karyopherin/importin that interacts with the nuclear pore complex acts as the nuclear import receptor for specific proteins including Pdr1p Yap1p Ste12p and Aft1p; uncharacterized protein 1226402 2892375 KLLA0_C14157g Kluyveromyces lactis uncharacterized protein XP_452833.1 1223130 R 28985 CDS KLLA0_C14190g 2892354 complement(1227049..1228836) C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 1228836 2892354 KLLA0_C14190g Kluyveromyces lactis uncharacterized protein XP_452835.1 1227049 R 28985 CDS KLLA0_C14212g 2892339 complement(1229219..1232341) C 1 NC_006039.1 weakly similar to uniprot|P25611 Saccharomyces cerevisiae YCR106W RDS1 Regulator of drug sensitivity transcriptional regulator; uncharacterized protein 1232341 2892339 KLLA0_C14212g Kluyveromyces lactis uncharacterized protein XP_452836.1 1229219 R 28985 CDS KLLA0_C14234g 2892342 1234598..1238962 C 1 NC_006039.1 similar to uniprot|P53049 Saccharomyces cerevisiae YGR281W YOR1 Plasma membrane transporter of the ATP-binding cassette (ABC) family mediates export of many different organic anions including oligomycin; ATP-binding cassette transporter YOR1 1238962 2892342 KLLA0_C14234g Kluyveromyces lactis ATP-binding cassette transporter YOR1 XP_452837.1 1234598 D 28985 CDS KLLA0_C14256g 2892312 1239373..1240479 C 1 NC_006039.1 similar to uniprot|P22936 Saccharomyces cerevisiae YKL114C APN1 Major apurinic/apyrimidinic endonuclease 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents controls spontaneous mutations; DNA-(apurinic or apyrimidinic site) lyase APN1 1240479 2892312 KLLA0_C14256g Kluyveromyces lactis DNA-(apurinic or apyrimidinic site) lyase APN1 XP_452838.1 1239373 D 28985 CDS KLLA0_C14278g 2892348 1240990..1242615 C 1 NC_006039.1 similar to uniprot|P28708 Saccharomyces cerevisiae YKL116C PRR1 Protein kinase with a possible role in MAP kinase signaling in the pheromone response pathway; serine/threonine protein kinase PRR1 1242615 2892348 KLLA0_C14278g Kluyveromyces lactis serine/threonine protein kinase PRR1 XP_452839.1 1240990 D 28985 CDS KLLA0_C14300g 2892381 1242952..1243842 C 1 NC_006039.1 highly similar to uniprot|Q03161 Saccharomyces cerevisiae YMR099C Hypothetical ORF; glucose-6-phosphate 1-epimerase 1243842 2892381 KLLA0_C14300g Kluyveromyces lactis glucose-6-phosphate 1-epimerase XP_452840.1 1242952 D 28985 CDS KLLA0_C14322g 2892310 complement(1243993..1244547) C 1 NC_006039.1 similar to uniprot|P28707 Saccharomyces cerevisiae YKL117W; Hsp90 cochaperone SBA1 1244547 2892310 KLLA0_C14322g Kluyveromyces lactis Hsp90 cochaperone SBA1 XP_452841.1 1243993 R 28985 CDS KLLA0_C14344g 2892116 1245226..1249782 C 1 NC_006039.1 similar to uniprot|Q04781 Saccharomyces cerevisiae YMR247C Hypothetical ORF; ubiquitin-protein ligase RKR1 1249782 2892116 KLLA0_C14344g Kluyveromyces lactis ubiquitin-protein ligase RKR1 XP_452842.1 1245226 D 28985 CDS KLLA0_C14366g 2892336 1250171..1251532 C 1 NC_006039.1 similar to uniprot|Q12096 Saccharomyces cerevisiae YOR320C GNT1 N- acetylglucosaminyltransferase capable of modification of N- linked glycans in the Golgi apparatus; glucose N-acetyltransferase 1251532 2892336 KLLA0_C14366g Kluyveromyces lactis glucose N-acetyltransferase XP_452843.1 1250171 D 28985 CDS KLLA0_C14388g 2892073 complement(1251548..1252159) C 1 NC_006039.1 similar to uniprot|Q99181 Saccharomyces cerevisiae YOR319W; U2 snRNP complex subunit HSH49 1252159 2892073 KLLA0_C14388g Kluyveromyces lactis U2 snRNP complex subunit HSH49 XP_452844.1 1251548 R 28985 CDS KLLA0_C14410g 2891918 1254045..1255148 C 1 NC_006039.1 similar to uniprot|P21182 Saccharomyces cerevisiae YOL052C SPE2 S-adenosylmethionine decarboxylase; adenosylmethionine decarboxylase SPE2 1255148 2891918 KLLA0_C14410g Kluyveromyces lactis adenosylmethionine decarboxylase SPE2 XP_452845.1 1254045 D 28985 CDS KLLA0_C14432g 2892276 1256193..1257896 C 1 NC_006039.1 similar to uniprot|Q04792 Saccharomyces cerevisiae YMR250W GAD1 Glutamate decarboxylase converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism involved in response to oxidative stress; glutamate decarboxylase GAD1 1257896 2892276 KLLA0_C14432g Kluyveromyces lactis glutamate decarboxylase GAD1 XP_452846.1 1256193 D 28985 CDS KLLA0_C14454g 2891984 join(1262487..1262544,1263204..1264399) C 1 NC_006039.1 similar to uniprot|P38248 Saccharomyces cerevisiae YBR078w and to uniprot|Q12355 Saccharomyces cerevisiae YDR055w; uncharacterized protein 1264399 2891984 KLLA0_C14454g Kluyveromyces lactis uncharacterized protein XP_452847.1 1262487 D 28985 CDS KLLA0_C14476g 2892625 complement(1265344..1265934) C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 1265934 2892625 KLLA0_C14476g Kluyveromyces lactis uncharacterized protein XP_452848.1 1265344 R 28985 CDS KLLA0_C14498g 2892152 complement(1266410..1269187) C 1 NC_006039.1 similar to uniprot|P38249 Saccharomyces cerevisiae YBR079C RPG1 Subunit of the core complex of translation initiation factor 3(eIF3) essential for translation part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes; translation initiation factor eIF3 core subunit a 1269187 2892152 KLLA0_C14498g Kluyveromyces lactis translation initiation factor eIF3 core subunit a XP_452849.1 1266410 R 28985 CDS KLLA0_C14520g 2892684 complement(1269505..1271799) C 1 NC_006039.1 highly similar to uniprot|P18759 Saccharomyces cerevisiae YBR080C SEC18 ATPase required for the release of Sec17p during the 'priming' step in homotypic vacuole fusion and for ER to Golgi transport homolog of the mammalian NSF; AAA family ATPase SEC18 1271799 2892684 KLLA0_C14520g Kluyveromyces lactis AAA family ATPase SEC18 XP_452850.1 1269505 R 28985 CDS KLLA0_C14542g 2891982 1272215..1273195 C 1 NC_006039.1 similar to uniprot|Q6Q5S5 Saccharomyces cerevisiae YDR313C PIB1 RING-type ubiquitin ligase of the endosomal and vacuolar membranes binds phosphatidylinositol(3)-phosphate contains a FYVE finger domain; phosphatidylinositol-3-phosphate-binding ubiquitin-protein ligase 1273195 2891982 KLLA0_C14542g Kluyveromyces lactis phosphatidylinositol-3-phosphate-binding ubiquitin-protein ligase XP_452851.1 1272215 D 28985 CDS KLLA0_C14564g 2891891 1273731..1274228 C 1 NC_006039.1 similar to uniprot|P46973 Saccharomyces cerevisiae YJR055W HIT1 Protein of unknown function required for growth at high temperature; uncharacterized protein 1274228 2891891 KLLA0_C14564g Kluyveromyces lactis uncharacterized protein XP_452852.1 1273731 D 28985 CDS KLLA0_C14586g 2892607 complement(1274520..1275944) C 1 NC_006039.1 similar to uniprot|Q12153 Saccharomyces cerevisiae YDR312W SSF2 high copy suppressor of G beta subunit temperature sensitive mutation possibly involved in mating; uncharacterized protein 1275944 2892607 KLLA0_C14586g Kluyveromyces lactis uncharacterized protein XP_452853.1 1274520 R 28985 CDS KLLA0_C14608g 2891839 1276354..1277817 C 1 NC_006039.1 highly similar to uniprot|P38712 Saccharomyces cerevisiae YHR065C RRP3 Required for maturation of the 35S primary transcript of pre-rRNA and is required for cleavages leading to mature 18S RNA RRP3 is a DEAD box gene homologous to eIF-4a which encodes an RNA-dependent ATPase possessing helicase activity which is not specific for RNA; RNA-dependent ATPase RRP3 1277817 2891839 KLLA0_C14608g Kluyveromyces lactis RNA-dependent ATPase RRP3 XP_452854.1 1276354 D 28985 CDS KLLA0_C14630g 2891995 complement(1277914..1279776) C 1 NC_006039.1 similar to uniprot|P32776 Saccharomyces cerevisiae YDR311W TFB1 Subunit of TFIIH and nucleotide excision repair factor 3 complexes required for nucleotide excision repair target for transcriptional activators; TFIIH/NER complex subunit TFB1 1279776 2891995 KLLA0_C14630g Kluyveromyces lactis TFIIH/NER complex subunit TFB1 XP_452855.1 1277914 R 28985 CDS KLLA0_C14652g 2892207 1280333..1281970 C 1 NC_006039.1 similar to uniprot|P38788 Saccharomyces cerevisiae YHR064C SSZ1 DnaK homolog interacts with Zuo1p (DnaJ homolog) to form a ribosome-associated complex (RAC) that is bound to the ribosome via the Zuo1p subunit Hsp70 Protein; uncharacterized protein 1281970 2892207 KLLA0_C14652g Kluyveromyces lactis uncharacterized protein XP_452856.1 1280333 D 28985 CDS KLLA0_C14674g 2891952 1282309..1283418 C 1 NC_006039.1 similar to uniprot|P38787 Saccharomyces cerevisiae YHR063C PAN5 2-dehydropantoate 2-reductase part of the pantothenic acid pathway structurally homologous to E. coli panE; 2-dehydropantoate 2-reductase PAN5 1283418 2891952 KLLA0_C14674g Kluyveromyces lactis 2-dehydropantoate 2-reductase PAN5 XP_452857.1 1282309 D 28985 CDS KLLA0_C14696g 2892500 1284151..1287006 C 1 NC_006039.1 some similarities with uniprot|P46676 Saccharomyces cerevisiae YDR310C SUM1 Suppressor of mar1-1 (sir2) mutation nuclear protein involved in silencing; uncharacterized protein 1287006 2892500 KLLA0_C14696g Kluyveromyces lactis uncharacterized protein XP_452858.1 1284151 D 28985 CDS KLLA0_C14718g 2892203 1287448..1288305 C 1 NC_006039.1 similar to uniprot|P38786 Saccharomyces cerevisiae YHR062C RPP1 Subunit of both RNase MRP which cleaves pre-rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends; RNA-binding RNA processing protein RPP1 1288305 2892203 KLLA0_C14718g Kluyveromyces lactis RNA-binding RNA processing protein RPP1 XP_452859.1 1287448 D 28985 CDS KLLA0_C14740g 2892011 1288826..1289386 C 1 NC_006039.1 no similarity; uncharacterized protein 1289386 2892011 KLLA0_C14740g Kluyveromyces lactis uncharacterized protein XP_452860.1 1288826 D 28985 CDS KLLA0_C14762g 2892679 1289858..1290964 C 1 NC_006039.1 weakly similar to uniprot|Q06648 Saccharomyces cerevisiae YDR309C GIC2 Protein of unknown function involved in initiation of budding and cellular polarization interacts with Cdc42p via the Cdc42/Rac- interactive binding (CRIB) domain; uncharacterized protein 1290964 2892679 KLLA0_C14762g Kluyveromyces lactis uncharacterized protein XP_452861.1 1289858 D 28985 CDS KLLA0_C14784g 2892143 complement(1291284..1291796) C 1 NC_006039.1 weakly similar to uniprot|P38784 Saccharomyces cerevisiae YHR060W VMA22 Protein involved in vacuolar H - ATPase assembly or function required for the biogenesis of a functional vacuolar ATPase (V-ATPase) but not part of the final enzyme complex; uncharacterized protein 1291796 2892143 KLLA0_C14784g Kluyveromyces lactis uncharacterized protein XP_452862.1 1291284 R 28985 CDS KLLA0_C14806g 2892325 1292017..1292448 C 1 NC_006039.1 similar to uniprot|P47822 Saccharomyces cerevisiae YDR308C SRB7 RNA polymerase II holoenzyme component; uncharacterized protein 1292448 2892325 KLLA0_C14806g Kluyveromyces lactis uncharacterized protein XP_452863.2 1292017 D 28985 CDS KLLA0_C14828g 2891876 complement(1292713..1294602) C 1 NC_006039.1 weakly similar to uniprot|Q06644 Saccharomyces cerevisiae YDR307W Hypothetical ORF; uncharacterized protein 1294602 2891876 KLLA0_C14828g Kluyveromyces lactis uncharacterized protein XP_452864.1 1292713 R 28985 CDS KLLA0_C14850g 2891897 1295153..1297036 C 1 NC_006039.1 no similarity; uncharacterized protein 1297036 2891897 KLLA0_C14850g Kluyveromyces lactis uncharacterized protein XP_452865.1 1295153 D 28985 CDS KLLA0_C14872g 2891973 1297342..1298298 C 1 NC_006039.1 highly similar to uniprot|P89104 Saccharomyces cerevisiae YDR460W; TFIIH/NER complex subunit TFB3 1298298 2891973 KLLA0_C14872g Kluyveromyces lactis TFIIH/NER complex subunit TFB3 XP_452866.1 1297342 D 28985 CDS KLLA0_C14894g 2892689 complement(1298490..1298963) C 1 NC_006039.1 similar to uniprot|Q03705 Saccharomyces cerevisiae YML036W Hypothetical ORF; uncharacterized protein 1298963 2892689 KLLA0_C14894g Kluyveromyces lactis uncharacterized protein XP_452867.1 1298490 R 28985 CDS KLLA0_C14905g 2892125 1299212..1300276 C 1 NC_006039.1 similar to uniprot|Q03703 Saccharomyces cerevisiae YML037C Hypothetical ORF; uncharacterized protein 1300276 2892125 KLLA0_C14905g Kluyveromyces lactis uncharacterized protein XP_452868.1 1299212 D 28985 CDS KLLA0_C14916g 9487341 complement(1300320..1300580) C 1 NC_006039.1 some similarities with uniprot|Q2V2P7 Saccharomyces cerevisiae YDR461C-A; uncharacterized protein 1300580 9487341 KLLA0_C14916g Kluyveromyces lactis uncharacterized protein XP_002999360.1 1300320 R 28985 CDS KLLA0_C14927g 2891990 1301197..1301640 C 1 NC_006039.1 similar to uniprot|P36527 Saccharomyces cerevisiae YDR462W MRPL28 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein mL40 1301640 2891990 KLLA0_C14927g Kluyveromyces lactis mitochondrial 54S ribosomal protein mL40 XP_452869.1 1301197 D 28985 CDS KLLA0_C14949g 2892633 complement(1302087..1303895) C 1 NC_006039.1 weakly similar to uniprot|Q6B229 Saccharomyces cerevisiae YOL137W; uncharacterized protein 1303895 2892633 KLLA0_C14949g Kluyveromyces lactis uncharacterized protein XP_452870.1 1302087 R 28985 CDS KLLA0_C14971g 2891878 1305101..1306438 C 1 NC_006039.1 some similarities with uniprot|Q04934 Saccharomyces cerevisiae YDR229W IVY1 Phospholipid-binding protein that interacts with both Ypt7p and Vps33p may partially counteract the action of Vps33p and vice versa localizes to the rim of the vacuole as cells approach stationary phase; uncharacterized protein 1306438 2891878 KLLA0_C14971g Kluyveromyces lactis uncharacterized protein XP_452871.1 1305101 D 28985 CDS KLLA0_C14993g 2892124 complement(1306550..1307509) C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 1307509 2892124 KLLA0_C14993g Kluyveromyces lactis uncharacterized protein XP_452872.1 1306550 R 28985 CDS KLLA0_C15015g 2891842 complement(1308053..1308610) C 1 NC_006039.1 similar to uniprot|Q04935 Saccharomyces cerevisiae YDR231C COX20 Mitochondrial inner membrane protein required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase; uncharacterized protein 1308610 2891842 KLLA0_C15015g Kluyveromyces lactis uncharacterized protein XP_452873.1 1308053 R 28985 CDS KLLA0_C15037g 2891826 1309296..1310810 C 1 NC_006039.1 weakly similar to uniprot|Q07622 Saccharomyces cerevisiae YDL203C Hypothetical ORF; uncharacterized protein 1310810 2891826 KLLA0_C15037g Kluyveromyces lactis uncharacterized protein XP_452874.1 1309296 D 28985 CDS KLLA0_C15059g 2892616 1311550..1313262 C 1 NC_006039.1 uniprot|P78698 Kluyveromyces lactis KLLA0C15059g HEM1 5- aminolevulinate synthase mitochondrial precursor; 5-aminolevulinate synthase 1313262 2892616 KLLA0_C15059g Kluyveromyces lactis 5-aminolevulinate synthase XP_452875.1 1311550 D 28985 CDS KLLA0_C15081g 2892620 complement(1314304..1315161) C 1 NC_006039.1 similar to uniprot|Q04947 Saccharomyces cerevisiae YDR233C RTN1 reticulon gene member of the RTNLA (reticulon-like A) subfamily; uncharacterized protein 1315161 2892620 KLLA0_C15081g Kluyveromyces lactis uncharacterized protein XP_452876.1 1314304 R 28985 CDS KLLA0_C15125g 2891978 1316235..1318316 C 1 NC_006039.1 highly similar to uniprot|P49367 Saccharomyces cerevisiae YDR234W LYS4 Homoaconitase catalyzes the conversion of homocitrate to homoisocitrate which is a step in the lysine biosynthesis pathway; homoaconitate hydratase LYS4 1318316 2891978 KLLA0_C15125g Kluyveromyces lactis homoaconitate hydratase LYS4 XP_452878.1 1316235 D 28985 CDS KLLA0_C15147g 2892205 1319226..1320209 C 1 NC_006039.1 similar to uniprot|P28789 Saccharomyces cerevisiae YDL205C HEM3 Phorphobilinogen deaminase catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane the third step in the heme biosynthetic pathway localizes to both the cytoplasm and nucleus expression is regulated by Hap2p-Hap3p; hydroxymethylbilane synthase 1320209 2892205 KLLA0_C15147g Kluyveromyces lactis hydroxymethylbilane synthase XP_452879.1 1319226 D 28985 CDS KLLA0_C15169g 2892680 1320694..1322343 C 1 NC_006039.1 similar to uniprot|Q03776 Saccharomyces cerevisiae YDR235W PRP42 U1 snRNP protein involved in splicing required for U1 snRNP biogenesis contains multiple tetriatricopeptide repeats; mRNA splicing protein PRP42 1322343 2892680 KLLA0_C15169g Kluyveromyces lactis mRNA splicing protein PRP42 XP_452880.1 1320694 D 28985 CDS KLLA0_C15191g 2892585 complement(1322363..1324417) C 1 NC_006039.1 weakly similar to uniprot|P47144 Saccharomyces cerevisiae YJR106W ECM27 Non-essential protein of unknown function; uncharacterized protein 1324417 2892585 KLLA0_C15191g Kluyveromyces lactis uncharacterized protein XP_452881.1 1322363 R 28985 CDS KLLA0_C15213g 2891986 complement(1324914..1325471) C 1 NC_006039.1 similar to uniprot|Q03778 Saccharomyces cerevisiae YDR236C FMN1 Riboflavin kinase phosphorylates riboflavin to form riboflavin monophosphate (FMN) which is a necessary cofactor for many enzymes localizes to microsomes and to the mitochondrial inner membrane; riboflavin kinase 1325471 2891986 KLLA0_C15213g Kluyveromyces lactis riboflavin kinase XP_452882.1 1324914 R 28985 CDS KLLA0_C15235g 2891927 complement(1325851..1327485) C 1 NC_006039.1 similar to uniprot|Q12315 Saccharomyces cerevisiae YDL207W GLE1 Cytoplasmic nucleoporin required for polyadenylated RNA export but not for protein import component of Nup82p nuclear pore subcomplex contains a nuclear export signal; nucleoporin GLE1 1327485 2891927 KLLA0_C15235g Kluyveromyces lactis nucleoporin GLE1 XP_452883.1 1325851 R 28985 CDS KLLA0_C15257g 2891923 1327926..1328795 C 1 NC_006039.1 highly similar to uniprot|P36519 Saccharomyces cerevisiae YDR237W MRPL7 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein uL5m 1328795 2891923 KLLA0_C15257g Kluyveromyces lactis mitochondrial 54S ribosomal protein uL5m XP_452884.1 1327926 D 28985 CDS KLLA0_C15279g 2892463 complement(1329012..1331927) C 1 NC_006039.1 highly similar to uniprot|P41810 Saccharomyces cerevisiae YDR238C SEC26 Involved in endoplasmic-to-Golgi protein trafficking encodes a subunit of yeast coatomer; coatomer subunit beta 1331927 2892463 KLLA0_C15279g Kluyveromyces lactis coatomer subunit beta XP_452885.1 1329012 R 28985 CDS KLLA0_C15301g 2892618 complement(1332183..1334285) C 1 NC_006039.1 weakly similar to uniprot|Q03780 Saccharomyces cerevisiae YDR239C Hypothetical ORF; uncharacterized protein 1334285 2892618 KLLA0_C15301g Kluyveromyces lactis uncharacterized protein XP_452886.1 1332183 R 28985 CDS KLLA0_C15323g 2891910 complement(1334700..1336088) C 1 NC_006039.1 weakly similar to uniprot|Q03782 Saccharomyces cerevisiae YDR240C SNU56 U1 snRNP protein serine-rich has no counterpart in mammalian U1 snRNP; uncharacterized protein 1336088 2891910 KLLA0_C15323g Kluyveromyces lactis uncharacterized protein XP_452887.1 1334700 R 28985 CDS KLLA0_C15345g 2892459 complement(1336577..1337026) C 1 NC_006039.1 similar to uniprot|P32495 Saccharomyces cerevisiae YDL208W NHP2 Nuclear protein related to mammalian high mobility group (HMG) proteins essential for function of H/ACA-type snoRNPs which are involved in 18S rRNA processing; snoRNA-binding protein NHP2 1337026 2892459 KLLA0_C15345g Kluyveromyces lactis snoRNA-binding protein NHP2 XP_452888.1 1336577 R 28985 CDS KLLA0_C15411g 2892477 1337984..1338997 C 1 NC_006039.1 similar to uniprot|Q12046 Saccharomyces cerevisiae YDL209C; uncharacterized protein 1338997 2892477 KLLA0_C15411g Kluyveromyces lactis uncharacterized protein XP_452889.1 1337984 D 28985 CDS KLLA0_C15433g 2892649 complement(1339439..1341058) C 1 NC_006039.1 similar to uniprot|P23394 Saccharomyces cerevisiae YDR243C PRP28 RNA helicase in the DEAD-box family involved in RNA isomerization at the 5' splice site; mRNA splicing protein PRP28 1341058 2892649 KLLA0_C15433g Kluyveromyces lactis mRNA splicing protein PRP28 XP_452890.1 1339439 R 28985 CDS KLLA0_C15455g 2892605 1341570..1343270 C 1 NC_006039.1 similar to uniprot|P35056 Saccharomyces cerevisiae YDR244W PEX5 Essential for import of proteins with SKL-like import signal into peroxisomal matrix 69-kDa protein containing tetratricopeptide repeat (TPR); uncharacterized protein 1343270 2892605 KLLA0_C15455g Kluyveromyces lactis uncharacterized protein XP_452891.1 1341570 D 28985 CDS KLLA0_C15477g 2892480 1343847..1344842 C 1 NC_006039.1 uniprot|Q70KX5 Kluyveromyces lactis mnn10 Golgi mannosyltransferase complex subunit; alpha-1,6-mannosyltransferase 1344842 2892480 KLLA0_C15477g Kluyveromyces lactis alpha-1,6-mannosyltransferase XP_452892.1 1343847 D 28985 CDS KLLA0_C15499g 2892034 complement(1345201..1346715) C 1 NC_006039.1 similar to uniprot|P20447 Saccharomyces cerevisiae YGL078C DBP3 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; RNA-dependent ATPase DBP3 1346715 2892034 KLLA0_C15499g Kluyveromyces lactis RNA-dependent ATPase DBP3 XP_452893.1 1345201 R 28985 CDS KLLA0_C15521g 2892060 complement(1347098..1348741) C 1 NC_006039.1 similar to uniprot|P19807 Saccharomyces cerevisiae YGL077C HNM1 Choline transporter (permease) that also controls the uptake of nitrogen mustard expression is co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol; uncharacterized protein 1348741 2892060 KLLA0_C15521g Kluyveromyces lactis uncharacterized protein XP_452894.1 1347098 R 28985 CDS KLLA0_C15543g 2892570 1349181..1352129 C 1 NC_006039.1 similar to uniprot|Q06839 Saccharomyces cerevisiae YPR097W mitochondrial protein; uncharacterized protein 1352129 2892570 KLLA0_C15543g Kluyveromyces lactis uncharacterized protein XP_452895.1 1349181 D 28985 CDS KLLA0_C15565g 2891926 complement(1352197..1352793) C 1 NC_006039.1 similar to uniprot|P53251 Saccharomyces cerevisiae YGR081C; uncharacterized protein 1352793 2891926 KLLA0_C15565g Kluyveromyces lactis uncharacterized protein XP_452896.1 1352197 R 28985 CDS KLLA0_C15587g 2891997 1353557..1354111 C 1 NC_006039.1 highly similar to uniprot|P35180 Saccharomyces cerevisiae YGR082W TOM20 Translocase of Outer Mitochondrial membrane; uncharacterized protein 1354111 2891997 KLLA0_C15587g Kluyveromyces lactis uncharacterized protein XP_452897.1 1353557 D 28985 CDS KLLA0_C15609g 2892121 complement(1354736..1355074) C 1 NC_006039.1 highly similar to uniprot|Q06089 Saccharomyces cerevisiae YPR098C Hypothetical ORF; uncharacterized protein 1355074 2892121 KLLA0_C15609g Kluyveromyces lactis uncharacterized protein XP_452898.1 1354736 R 28985 CDS KLLA0_C15653g 2892031 1356426..1359467 C 1 NC_006039.1 some similarities with uniprot|Q06836 Saccharomyces cerevisiae YPR095C SYT1 Suppressor of Ypt3; Arf family guanine nucleotide exchange factor SYT1 1359467 2892031 KLLA0_C15653g Kluyveromyces lactis Arf family guanine nucleotide exchange factor SYT1 XP_452899.1 1356426 D 28985 CDS KLLA0_C15675g 2892695 complement(1359680..1360015) C 1 NC_006039.1 similar to uniprot|Q06835 Saccharomyces cerevisiae YPR094W RDS3 essential zinc finger protein; U2 snRNP complex subunit RDS3 1360015 2892695 KLLA0_C15675g Kluyveromyces lactis U2 snRNP complex subunit RDS3 XP_452900.1 1359680 R 28985 CDS KLLA0_C15697g 2892676 1360289..1361203 C 1 NC_006039.1 similar to uniprot|Q06834 Saccharomyces cerevisiae YPR093C ASR1 Protein involved in a putative alcohol-responsive signaling pathway accumulates in the nucleus under alcohol stress contains a Ring/PHD finger domain; ubiquitin-protein ligase ASR1 1361203 2892676 KLLA0_C15697g Kluyveromyces lactis ubiquitin-protein ligase ASR1 XP_452901.1 1360289 D 28985 CDS KLLA0_C15719g 2891912 complement(1361328..1362275) C 1 NC_006039.1 similar to uniprot|Q75DC1 Ashbya gossypii ABR105C ABR105Cp and weakly similar to YGR080W uniprot|P53250 Saccharomyces cerevisiae YGR080W TWF1 Twinfilin A member of a conserved family of actin monomer sequestering proteins comprised almost entirely of two tandem repeats each having sequence homology with cofilin (Cof1p); uncharacterized protein 1362275 2891912 KLLA0_C15719g Kluyveromyces lactis uncharacterized protein XP_452902.1 1361328 R 28985 CDS KLLA0_C15741g 2892637 complement(1362669..1363586) C 1 NC_006039.1 some similarities with uniprot|P53249 Saccharomyces cerevisiae YGR079W; uncharacterized protein 1363586 2892637 KLLA0_C15741g Kluyveromyces lactis uncharacterized protein XP_452903.1 1362669 R 28985 CDS KLLA0_C15763g 2892290 1365488..1367839 C 1 NC_006039.1 similar to uniprot|Q06833 Saccharomyces cerevisiae YPR091C Hypothetical ORF; uncharacterized protein 1367839 2892290 KLLA0_C15763g Kluyveromyces lactis uncharacterized protein XP_452904.1 1365488 D 28985 CDS KLLA0_C15785g 2892483 complement(1367880..1374743) C 1 NC_006039.1 similar to uniprot|P38111 Saccharomyces cerevisiae YBR136W MEC1 Central regulator of the Mec1p/Tel1p signaling network; required for mitotic growth, DNA repair and mitotic recombination, regulates phosphorylation of Rad53p, required for dmc1 arrest and meiotic recombination; similar to phosphatidylinositol (PI)3- kinases required for DNA damage induced checkpoint responses in G1, S/M, intra S, and G2/M in mitosis; protein kinase MEC1 1374743 2892483 KLLA0_C15785g Kluyveromyces lactis protein kinase MEC1 XP_452905.1 1367880 R 28985 CDS KLLA0_C15807g 2892550 complement(1375152..1375550) C 1 NC_006039.1 highly similar to uniprot|P20486 Saccharomyces cerevisiae YBR135W CKS1 Subunit of the Cdc28 protein kinase required for mitotic proteolysis may also be involved in the proteolysis of the G1 cyclins; cyclin-dependent protein kinase regulatory subunit CKS1 1375550 2892550 KLLA0_C15807g Kluyveromyces lactis cyclin-dependent protein kinase regulatory subunit CKS1 XP_452906.1 1375152 R 28985 CDS KLLA0_C15829g 2892269 1375908..1378244 C 1 NC_006039.1 similar to uniprot|P38274 Saccharomyces cerevisiae YBR133C HSL7 Protein arginine N-methyltransferase, bud neck localization; protein arginine N-methyltransferase 1378244 2892269 KLLA0_C15829g Kluyveromyces lactis protein arginine N-methyltransferase XP_452907.1 1375908 D 28985 CDS KLLA0_C15851g 2892581 complement(1378324..1380579) C 1 NC_006039.1 similar to uniprot|O13585 Saccharomyces cerevisiae YPR089W Hypothetical ORF; uncharacterized protein 1380579 2892581 KLLA0_C15851g Kluyveromyces lactis uncharacterized protein XP_452908.1 1378324 R 28985 CDS KLLA0_C15873g 2892026 1381699..1383405 C 1 NC_006039.1 similar to uniprot|P38090 Saccharomyces cerevisiae YBR132C AGP2 Plasma membrane carnitine transporter expression is down-regulated by osmotic stress also functions as a low-affinity amino acid permease; uncharacterized protein 1383405 2892026 KLLA0_C15873g Kluyveromyces lactis uncharacterized protein XP_452909.1 1381699 D 28985 CDS KLLA0_C15895g 2891812 1383929..1385332 C 1 NC_006039.1 highly similar to uniprot|Q12464 Saccharomyces cerevisiae YPL235W RVB2 RUVB-like protein TIP49b Homologue; RuvB family ATP-dependent DNA helicase reptin 1385332 2891812 KLLA0_C15895g Kluyveromyces lactis RuvB family ATP-dependent DNA helicase reptin XP_452910.1 1383929 D 28985 CDS KLLA0_C15917g 2892063 complement(1385605..1386102) C 1 NC_006039.1 highly similar to uniprot|P32842 Saccharomyces cerevisiae YPL234C TFP3 vacuolar ATPase V0 domain subunit c'; H(+)-transporting V0 sector ATPase subunit c' 1386102 2892063 KLLA0_C15917g Kluyveromyces lactis H(+)-transporting V0 sector ATPase subunit c' XP_452911.1 1385605 R 28985 CDS KLLA0_C15939g 2892471 1386474..1387124 C 1 NC_006039.1 weakly similar to uniprot|Q6B152 Saccharomyces cerevisiae YPL233W NSL1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation; MIND complex subunit NSL1 1387124 2892471 KLLA0_C15939g Kluyveromyces lactis MIND complex subunit NSL1 XP_452912.1 1386474 D 28985 CDS KLLA0_C15961g 2892061 1387763..1388623 C 1 NC_006039.1 similar to uniprot|P39926 Saccharomyces cerevisiae YMR183C SSO2 encode syntaxin homolog act in late stages of secretion post-Golgi t-SNARE; syntaxin 1388623 2892061 KLLA0_C15961g Kluyveromyces lactis syntaxin XP_452913.1 1387763 D 28985 CDS KLLA0_C15983g 2892173 1389936..1395617 C 1 NC_006039.1 similar to uniprot|P19097 Saccharomyces cerevisiae YPL231W FAS2 Alpha subunit of fatty acid synthetase which catalyzes the synthesis of long-chain saturated fatty acids contains beta-ketoacyl reductase and beta-ketoacyl synthase activities; trifunctional fatty acid synthase subunit FAS2 1395617 2892173 KLLA0_C15983g Kluyveromyces lactis trifunctional fatty acid synthase subunit FAS2 XP_452914.1 1389936 D 28985 CDS KLLA0_C16005g 2892260 1397274..1398269 C 1 NC_006039.1 some similarities with uniprot|Q12132 Saccharomyces cerevisiae YPL230W USV1 Up in StarVation; uncharacterized protein 1398269 2892260 KLLA0_C16005g Kluyveromyces lactis uncharacterized protein XP_452915.1 1397274 D 28985 CDS KLLA0_C16027g 2891862 1398915..1399481 C 1 NC_006039.1 weakly similar to uniprot|Q99395 Saccharomyces cerevisiae YPL229W Hypothetical ORF; uncharacterized protein 1399481 2891862 KLLA0_C16027g Kluyveromyces lactis uncharacterized protein XP_452916.1 1398915 D 28985 CDS KLLA0_C16049g 2892078 1399865..1401535 C 1 NC_006039.1 similar to uniprot|O13297 Saccharomyces cerevisiae YPL228W CET1 Interacts with Ceg1p the mRNA capping enzyme alpha subunit removes gamma-phosphate from triphosphate-terminated RNA mRNA capping enzyme beta subunit RNA 5'-triphosphatase; polynucleotide 5'-phosphatase 1401535 2892078 KLLA0_C16049g Kluyveromyces lactis polynucleotide 5'-phosphatase XP_452917.1 1399865 D 28985 CDS KLLA0_C16071g 2892613 complement(1401692..1402654) C 1 NC_006039.1 similar to uniprot|P40350 Saccharomyces cerevisiae YPL227C ALG5 UDP-glucose:dolichyl-phosphate glucosyltransferase involved in asparagine-linked glycosylation in the endoplasmic reticulum; dolichyl-phosphate beta-glucosyltransferase 1402654 2892613 KLLA0_C16071g Kluyveromyces lactis dolichyl-phosphate beta-glucosyltransferase XP_452918.1 1401692 R 28985 CDS KLLA0_C16093g 2892693 complement(1403085..1404977) C 1 NC_006039.1 weakly similar to uniprot|P35209 Saccharomyces cerevisiae YMR179W SPT21 Protein required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2 but not required at the other histone loci functionally related to Spt10p; uncharacterized protein 1404977 2892693 KLLA0_C16093g Kluyveromyces lactis uncharacterized protein XP_452919.1 1403085 R 28985 CDS KLLA0_C16115g 2892191 1405766..1409317 C 1 NC_006039.1 similar to uniprot|Q7LHP2 Saccharomyces cerevisiae YPL226W NEW1 This gene encodes a protein with an Q/N-rich amino terminal domain that acts as a prion termed [NU]; uncharacterized protein 1409317 2892191 KLLA0_C16115g Kluyveromyces lactis uncharacterized protein XP_452920.1 1405766 D 28985 CDS KLLA0_C16137g 2892184 complement(1409593..1410417) C 1 NC_006039.1 similar to uniprot|Q03219 Saccharomyces cerevisiae YMR178W Hypothetical ORF; uncharacterized protein 1410417 2892184 KLLA0_C16137g Kluyveromyces lactis uncharacterized protein XP_452921.1 1409593 R 28985 CDS KLLA0_C16159g 2892631 1410778..1411215 C 1 NC_006039.1 highly similar to uniprot|Q08971 Saccharomyces cerevisiae YPL225W Hypothetical ORF; ribosome-associated Tef1p biogenesis chaperone CHP1 1411215 2892631 KLLA0_C16159g Kluyveromyces lactis ribosome-associated Tef1p biogenesis chaperone CHP1 XP_452922.1 1410778 D 28985 CDS KLLA0_C16181g 2892050 complement(1411619..1413160) C 1 NC_006039.1 similar to uniprot|Q03218 Saccharomyces cerevisiae YMR177W MMT1 Putative metal transporter involved in mitochondrial iron accumulation closely related to Mmt2p; uncharacterized protein 1413160 2892050 KLLA0_C16181g Kluyveromyces lactis uncharacterized protein XP_452923.1 1411619 R 28985 CDS KLLA0_C16203g 2892169 complement(1414169..1418533) C 1 NC_006039.1 similar to uniprot|Q03214 Saccharomyces cerevisiae YMR176W ECM5 Non-essential protein of unknown function contains ATP/GTP-binding site motif A null mutant exhibits cellular volume up to four times greater than wild-type also large drooping buds with elongated necks; uncharacterized protein 1418533 2892169 KLLA0_C16203g Kluyveromyces lactis uncharacterized protein XP_452924.1 1414169 R 28985 CDS KLLA0_C16225g 2892524 complement(1419986..1420543) C 1 NC_006039.1 weakly similar to uniprot|Q08969 Saccharomyces cerevisiae YPL223C Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; uncharacterized protein 1420543 2892524 KLLA0_C16225g Kluyveromyces lactis uncharacterized protein XP_452925.1 1419986 R 28985 CDS KLLA0_C16247g 2892452 1421680..1423089 C 1 NC_006039.1 similar to uniprot|P53378 Saccharomyces cerevisiae YLR212C TUB4 Gamma-tubulin involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; gamma-tubulin 1423089 2892452 KLLA0_C16247g Kluyveromyces lactis gamma-tubulin XP_452926.1 1421680 D 28985 CDS KLLA0_C16269g 2892042 complement(1423302..1424756) C 1 NC_006039.1 similar to uniprot|Q12342 Saccharomyces cerevisiae YDL146W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm bud and bud neck; uncharacterized protein 1424756 2892042 KLLA0_C16269g Kluyveromyces lactis uncharacterized protein XP_452927.1 1423302 R 28985 CDS KLLA0_C16291g 2892196 join(1425052..1425072,1425156..1425749) C 1 NC_006039.1 similar to uniprot|Q05789 Saccharomyces cerevisiae YLR211C Hypothetical ORF; uncharacterized protein 1425749 2892196 KLLA0_C16291g Kluyveromyces lactis uncharacterized protein XP_452928.1 1425052 D 28985 CDS KLLA0_C16313g 2892084 complement(1425869..1427194) C 1 NC_006039.1 highly similar to uniprot|Q12250 Saccharomyces cerevisiae YDL147W RPN5 Essential, non-ATPase regulatory subunit of the 26S proteasome lid; proteasome regulatory particle lid subunit RPN5 1427194 2892084 KLLA0_C16313g Kluyveromyces lactis proteasome regulatory particle lid subunit RPN5 XP_452929.1 1425869 R 28985 CDS KLLA0_C16335g 2891936 1427751..1430264 C 1 NC_006039.1 similar to uniprot|Q99207 Saccharomyces cerevisiae YDL148C NOP14 Nucleolar protein forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits also present in the small subunit processome complex which is required for processing of pre-18S rRNA; snoRNA-binding rRNA-processing protein NOP14 1430264 2891936 KLLA0_C16335g Kluyveromyces lactis snoRNA-binding rRNA-processing protein NOP14 XP_452930.1 1427751 D 28985 CDS KLLA0_C16357g 2892175 complement(1430306..1433032) C 1 NC_006039.1 similar to uniprot|Q12142 Saccharomyces cerevisiae YDL149W ATG9 Transmembrane protein involved in formation of Cvt and autophagic vesicles cycles between the pre-autophagosomal structure and other cytosolic punctate structures not found in autophagosomes; autophagy protein ATG9 1433032 2892175 KLLA0_C16357g Kluyveromyces lactis autophagy protein ATG9 XP_452931.1 1430306 R 28985 CDS KLLA0_C16379g 2892090 complement(1433447..1434661) C 1 NC_006039.1 similar to uniprot|P25441 Saccharomyces cerevisiae YDL150W RPC53 RNA polymerase III subunit C53; DNA-directed RNA polymerase III subunit C53 1434661 2892090 KLLA0_C16379g Kluyveromyces lactis DNA-directed RNA polymerase III subunit C53 XP_452932.1 1433447 R 28985 CDS KLLA0_C16401g 2891806 1435065..1436903 C 1 NC_006039.1 similar to uniprot|Q05842 Saccharomyces cerevisiae YDL153C SAS10 Component of the small (ribosomal) subunit (SSU) processosome required for pre-18S rRNa processing essential nucleolar protein that when overproduced disrupts silencing; rRNA-processing protein SAS10 1436903 2891806 KLLA0_C16401g Kluyveromyces lactis rRNA-processing protein SAS10 XP_452933.1 1435065 D 28985 CDS KLLA0_C16423g 2892478 complement(1437001..1439805) C 1 NC_006039.1 similar to uniprot|Q12175 Saccharomyces cerevisiae YDL154W MSH5 Protein of the MutS family forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis msh5-Y823H mutation confers tolerance to DNA alkylating agents homologs present in C. elegans and humans; MutS family protein MSH5 1439805 2892478 KLLA0_C16423g Kluyveromyces lactis MutS family protein MSH5 XP_452934.1 1437001 R 28985 CDS KLLA0_C16445g 2892178 complement(1439975..1441309) C 1 NC_006039.1 similar to uniprot|P24871 Saccharomyces cerevisiae YLR210W CLB4 Involved in mitotic induction G(sub)2-specific B-type cyclin and uniprot|P24870 Saccharomyces cerevisiae YDL155W CLB3; uncharacterized protein 1441309 2892178 KLLA0_C16445g Kluyveromyces lactis uncharacterized protein XP_452935.1 1439975 R 28985 CDS KLLA0_C16467g 2892150 1442002..1443825 C 1 NC_006039.1 similar to uniprot|P46982 Saccharomyces cerevisiae YJL186W MNN5 Alpha-1 2-mannosyltransferase responsible for addition of the second alpha-1 2-linked mannose of the branches on the mannan backbone of oligosaccharides localizes to an early Golgi compartment; uncharacterized protein 1443825 2892150 KLLA0_C16467g Kluyveromyces lactis uncharacterized protein XP_452936.1 1442002 D 28985 CDS KLLA0_C16489g 2892558 1444456..1446642 C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 1446642 2892558 KLLA0_C16489g Kluyveromyces lactis uncharacterized protein XP_452937.1 1444456 D 28985 CDS KLLA0_C16511g 2891969 1447602..1448327 C 1 NC_006039.1 similar to uniprot|Q04170 Saccharomyces cerevisiae YDR391C Hypothetical ORF; uncharacterized protein 1448327 2891969 KLLA0_C16511g Kluyveromyces lactis uncharacterized protein XP_452938.1 1447602 D 28985 CDS KLLA0_C16533g 2892075 complement(1448866..1450404) C 1 NC_006039.1 similar to uniprot|Q12510 Saccharomyces cerevisiae YDL156W Hypothetical ORF; uncharacterized protein 1450404 2892075 KLLA0_C16533g Kluyveromyces lactis uncharacterized protein XP_452939.1 1448866 R 28985 CDS KLLA0_C16555g 2892058 1450673..1450996 C 1 NC_006039.1 similar to uniprot|Q12082 Saccharomyces cerevisiae YDL157C Hypothetical ORF; uncharacterized protein 1450996 2892058 KLLA0_C16555g Kluyveromyces lactis uncharacterized protein XP_452940.1 1450673 D 28985 CDS KLLA0_C16577g 2892563 complement(1451181..1452695) C 1 NC_006039.1 similar to uniprot|P06784 Saccharomyces cerevisiae YDL159W STE7 Signal transducing MAP kinase kinase involved in pheromone response where it phosphorylates Fus3p and in the pseudohyphal/invasive growth pathway through phosphorylation of Kss1p phosphorylated by Ste11p degraded by ubiquitin pathway; mitogen-activated protein kinase kinase STE7 1452695 2892563 KLLA0_C16577g Kluyveromyces lactis mitogen-activated protein kinase kinase STE7 XP_452941.1 1451181 R 28985 CDS KLLA0_C16599g 2892299 1453655..1455199 C 1 NC_006039.1 similar to uniprot|P39517 Saccharomyces cerevisiae YDL160C DHH1 Cytoplasmic DExD/H-box helicase stimulates mRNA decapping coordinates distinct steps in mRNA function and decay interacts with both the decapping and deadenylase complexes may have a role in mRNA export and translation; DExD/H-box ATP-dependent RNA helicase DHH1 1455199 2892299 KLLA0_C16599g Kluyveromyces lactis DExD/H-box ATP-dependent RNA helicase DHH1 XP_452942.1 1453655 D 28985 CDS KLLA0_C16621g 2891987 1456403..1457323 C 1 NC_006039.1 similar to uniprot|Q05788 Saccharomyces cerevisiae YLR209C PNP1 purine nucleoside phosphorylase specifically metabolizes inosine and guanosine nucleosides; purine-nucleoside phosphorylase 1457323 2891987 KLLA0_C16621g Kluyveromyces lactis purine-nucleoside phosphorylase XP_452943.1 1456403 D 28985 CDS KLLA0_C16643g 2892133 complement(1457590..1458498) C 1 NC_006039.1 highly similar to uniprot|Q04491 Saccharomyces cerevisiae YLR208W SEC13 Component of both the Nup84 nuclear pore sub-complex and of the COPII complex (Sar1p Sec13p Sec16p Sec23p Sec24p Sec31p Sfb2p and Sfb3p) which is important for the formation of ER to Golgi transport vesicles; GTPase-activating protein SEC13 1458498 2892133 KLLA0_C16643g Kluyveromyces lactis GTPase-activating protein SEC13 XP_452944.1 1457590 R 28985 CDS KLLA0_C16665g 2892485 complement(1458916..1461339) C 1 NC_006039.1 similar to uniprot|Q05787 Saccharomyces cerevisiae YLR207W HRD3 Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD) forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events; ubiquitin ligase complex subunit HRD3 1461339 2892485 KLLA0_C16665g Kluyveromyces lactis ubiquitin ligase complex subunit HRD3 XP_452945.1 1458916 R 28985 CDS KLLA0_C16687g 2892286 1461624..1462820 C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 1462820 2892286 KLLA0_C16687g Kluyveromyces lactis uncharacterized protein XP_452946.1 1461624 D 28985 CDS KLLA0_C16709g 2892126 1463056..1463295 C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 1463295 2892126 KLLA0_C16709g Kluyveromyces lactis uncharacterized protein XP_452947.1 1463056 D 28985 CDS KLLA0_C16731g 2892106 complement(1463616..1465052) C 1 NC_006039.1 some similarities with uniprot|Q12518 Saccharomyces cerevisiae YDL161W ENT1; epsin 1465052 2892106 KLLA0_C16731g Kluyveromyces lactis epsin XP_452948.1 1463616 R 28985 CDS KLLA0_C16753g 2892120 1465814..1465987 C 1 NC_006039.1 highly similar to uniprot|Q6Q547 Saccharomyces cerevisiae YHR072W-A NOP10 Constituent of small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs which are required for pseudouridylation and processing of pre-18S rRNA; snoRNP complex protein NOP10 1465987 2892120 KLLA0_C16753g Kluyveromyces lactis snoRNP complex protein NOP10 XP_452949.1 1465814 D 28985 CDS KLLA0_C16775g 2892496 complement(1466209..1466427) C 1 NC_006039.1 highly similar to uniprot|P69851 Saccharomyces cerevisiae YDR320C-A DAD4 Essential protein component of the DASH complex involved in spindle integrity and kinetochore function interacts with Duo1p and Dam1p localizes to intranuclear spindles and kinetochore; uncharacterized protein 1466427 2892496 KLLA0_C16775g Kluyveromyces lactis uncharacterized protein XP_452950.1 1466209 R 28985 CDS KLLA0_C16797g 2892456 1466983..1469925 C 1 NC_006039.1 some similarities with uniprot|P38713 Saccharomyces cerevisiae YHR073W OSH3 Member of an oxysterol-binding protein family with seven members in S. cerevisiae family members have overlapping redundant functions in sterol metabolism and collectively perform a function essential for viability; oxysterol-binding protein related protein OSH3 1469925 2892456 KLLA0_C16797g Kluyveromyces lactis oxysterol-binding protein related protein OSH3 XP_452951.1 1466983 D 28985 CDS KLLA0_C16819g 2892578 1470350..1470667 C 1 NC_006039.1 no similarity; uncharacterized protein 1470667 2892578 KLLA0_C16819g Kluyveromyces lactis uncharacterized protein XP_452952.1 1470350 D 28985 CDS KLLA0_C16874g 2892113 join(1473776..1473800,1474263..1475578) C 1 NC_006039.1 highly similar to uniprot|P09733 Saccharomyces cerevisiae YML085C TUB1 Alpha-tubulin associates with beta-tubulin (Tub2p) to form tubulin dimer which polymerizes to form microtubules; alpha-tubulin TUB1 1475578 2892113 KLLA0_C16874g Kluyveromyces lactis alpha-tubulin TUB1 XP_452955.1 1473776 D 28985 CDS KLLA0_C16896g 2892284 1476535..1478112 C 1 NC_006039.1 highly similar to uniprot|P54783 Saccharomyces cerevisiae YML086C ALO1 D-Arabinono-1 4-lactone oxidase catalyzes the final step in biosynthesis of D-erythroascorbic acid which is protective against oxidative stress; D-arabinono-1,4-lactone oxidase 1478112 2892284 KLLA0_C16896g Kluyveromyces lactis D-arabinono-1,4-lactone oxidase XP_452956.1 1476535 D 28985 CDS KLLA0_C16918g 2892579 1478540..1479472 C 1 NC_006039.1 similar to uniprot|Q12746 Saccharomyces cerevisiae YML125C Protein required for cell viability; uncharacterized protein 1479472 2892579 KLLA0_C16918g Kluyveromyces lactis uncharacterized protein XP_452957.1 1478540 D 28985 CDS KLLA0_C16940g 2891983 complement(1479541..1481469) C 1 NC_006039.1 similar to uniprot|Q04511 Saccharomyces cerevisiae YML088W UFO1 F-box receptor protein subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex binds to phosphorylated Ho endonuclease allowing its ubiquitylation by SCF and subsequent degradation; SCF ubiquitin ligase complex subunit UFO1 1481469 2891983 KLLA0_C16940g Kluyveromyces lactis SCF ubiquitin ligase complex subunit UFO1 XP_452958.1 1479541 R 28985 CDS KLLA0_C16984g 2892583 complement(1482004..1483650) C 1 NC_006039.1 similar to uniprot|P54791 Saccharomyces cerevisiae YPR162C ORC4 Subunit of the origin recognition complex which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; origin recognition complex subunit 4 1483650 2892583 KLLA0_C16984g Kluyveromyces lactis origin recognition complex subunit 4 XP_452959.1 1482004 R 28985 CDS KLLA0_C17006g 2892568 complement(1484995..1486968) C 1 NC_006039.1 weakly similar to uniprot|P53191 Saccharomyces cerevisiae YGL023C; uncharacterized protein 1486968 2892568 KLLA0_C17006g Kluyveromyces lactis uncharacterized protein XP_452960.1 1484995 R 28985 CDS KLLA0_C17028g 2892349 complement(1487806..1489188) C 1 NC_006039.1 similar to uniprot|P53101 Saccharomyces cerevisiae YGL184C STR3 Cystathionine beta-lyase converts cystathionine into homocysteine; cystathionine beta-lyase STR3 1489188 2892349 KLLA0_C17028g Kluyveromyces lactis cystathionine beta-lyase STR3 XP_452961.1 1487806 R 28985 CDS KLLA0_C17050g 2892574 1490472..1493339 C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 1493339 2892574 KLLA0_C17050g Kluyveromyces lactis uncharacterized protein XP_452962.1 1490472 D 28985 CDS KLLA0_C17072g 2891999 1494101..1495525 C 1 NC_006039.1 weakly similar to uniprot|P39959 Saccharomyces cerevisiae YER130C Hypothetical ORF; uncharacterized protein 1495525 2891999 KLLA0_C17072g Kluyveromyces lactis uncharacterized protein XP_452963.1 1494101 D 28985 CDS KLLA0_C17094g 2892154 complement(1495879..1496556) C 1 NC_006039.1 similar to uniprot|P53102 Saccharomyces cerevisiae YGL183C MND1 Protein required for recombination and meiotic nuclear division forms a complex with Hop2p which is involved in chromosome pairing and repair of meiotic double-strand breaks; uncharacterized protein 1496556 2892154 KLLA0_C17094g Kluyveromyces lactis uncharacterized protein XP_452964.1 1495879 R 28985 CDS KLLA0_C17138g 2892156 1497245..1498396 C 1 NC_006039.1 some similarities with uniprot|P40956 Saccharomyces cerevisiae YGL181W GTS1 Contains a zinc-finger in the N-terminus and a long Gln-rich region in the C-terminus regulates ultradian rhythm cell size cell cycle lifespan sporulation heat tolerance and multidrug transport; uncharacterized protein 1498396 2892156 KLLA0_C17138g Kluyveromyces lactis uncharacterized protein XP_452966.1 1497245 D 28985 CDS KLLA0_C17160g 2892164 1498959..1501454 C 1 NC_006039.1 similar to uniprot|P53104 Saccharomyces cerevisiae YGL180W ATG1 Protein serine/threonine kinase required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway; serine/threonine protein kinase ATG1 1501454 2892164 KLLA0_C17160g Kluyveromyces lactis serine/threonine protein kinase ATG1 XP_452967.1 1498959 D 28985 CDS KLLA0_C17182g 2892093 complement(1501733..1503865) C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 1503865 2892093 KLLA0_C17182g Kluyveromyces lactis uncharacterized protein XP_452968.1 1501733 R 28985 CDS KLLA0_C17204g 2892163 1504341..1506647 C 1 NC_006039.1 some similarities with uniprot|Q06704 Saccharomyces cerevisiae YLR309C IMH1 Protein involved in vesicular transport mediates transport between an endosomal compartment and the Golgi contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi; uncharacterized protein 1506647 2892163 KLLA0_C17204g Kluyveromyces lactis uncharacterized protein XP_452969.1 1504341 D 28985 CDS KLLA0_C17226g 2892653 complement(1506737..1507705) C 1 NC_006039.1 similar to uniprot|Q06703 Saccharomyces cerevisiae YLR308W CDA2 Chitin deacetylase together with Cda1p involved in the biosynthesis ascospore wall component chitosan required for proper rigidity of the ascospore wall; uncharacterized protein 1507705 2892653 KLLA0_C17226g Kluyveromyces lactis uncharacterized protein XP_452970.1 1506737 R 28985 CDS KLLA0_C17237g 9487525 1509151..1509396 C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 1509396 9487525 KLLA0_C17237g Kluyveromyces lactis uncharacterized protein XP_002999361.1 1509151 D 28985 CDS KLLA0_C17248g 2892100 complement(1509885..1510439) C 1 NC_006039.1 similar to uniprot|P52491 Saccharomyces cerevisiae YLR306W UBC12 Enzyme that mediates the conjugation of Rub1p a ubiquitin-like protein to other proteins related to E2 ubiquitin-conjugating enzymes; NEDD8-conjugating protein UBC12 1510439 2892100 KLLA0_C17248g Kluyveromyces lactis NEDD8-conjugating protein UBC12 XP_452971.1 1509885 R 28985 CDS KLLA0_C17270g 2892072 1510929..1512215 C 1 NC_006039.1 no similarity; uncharacterized protein 1512215 2892072 KLLA0_C17270g Kluyveromyces lactis uncharacterized protein XP_452972.1 1510929 D 28985 CDS KLLA0_C17292g 2892468 1512447..1518143 C 1 NC_006039.1 similar to uniprot|P37297 Saccharomyces cerevisiae YLR305C STT4 Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway required for normal vacuole morphology cell wall integrity and actin cytoskeleton organization; 1-phosphatidylinositol 4-kinase STT4 1518143 2892468 KLLA0_C17292g Kluyveromyces lactis 1-phosphatidylinositol 4-kinase STT4 XP_452973.1 1512447 D 28985 CDS KLLA0_C17314g 2891900 1519028..1521394 C 1 NC_006039.1 highly similar to uniprot|P19414 Saccharomyces cerevisiae YLR304C ACO1 Mitochondrial aconitase required for the tricarboxylic acid (TCA) cycle mutation leads to glutamate auxotrophy; aconitate hydratase ACO1 1521394 2891900 KLLA0_C17314g Kluyveromyces lactis aconitate hydratase ACO1 XP_452974.1 1519028 D 28985 CDS KLLA0_C17336g 2892580 1522475..1523923 C 1 NC_006039.1 similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport; uncharacterized protein 1523923 2892580 KLLA0_C17336g Kluyveromyces lactis uncharacterized protein XP_452975.1 1522475 D 28985 CDS KLLA0_C17380g 2892595 1524716..1528075 C 1 NC_006039.1 weakly similar to uniprot|P23201 Saccharomyces cerevisiae YLL021W SPA2 Component of the polarisome which functions in actin cytoskeletal organization during polarized growth acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components potential Cdc28p substrate; uncharacterized protein 1528075 2892595 KLLA0_C17380g Kluyveromyces lactis uncharacterized protein XP_452976.1 1524716 D 28985 CDS KLLA0_C17402g 2892280 complement(1528570..1529295) C 1 NC_006039.1 similar to uniprot|P36523 Saccharomyces cerevisiae YLR312W-A MRPL15 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein mL57 1529295 2892280 KLLA0_C17402g Kluyveromyces lactis mitochondrial 54S ribosomal protein mL57 XP_452977.1 1528570 R 28985 CDS KLLA0_C17424g 2892148 1529941..1531680 C 1 NC_006039.1 similar to uniprot|P45818 Saccharomyces cerevisiae YGL171W ROK1 ATP-dependent RNA helicase of the DEAD box family required for 18S rRNA synthesis; RNA-dependent ATPase ROK1 1531680 2892148 KLLA0_C17424g Kluyveromyces lactis RNA-dependent ATPase ROK1 XP_452978.1 1529941 D 28985 CDS KLLA0_C17446g 2892278 complement(1531978..1532337) C 1 NC_006039.1 similar to uniprot|Q12233 Saccharomyces cerevisiae YPR020W ATP20 Subunit g of the mitochondrial F1F0 ATP synthase which is a large enzyme complex required for ATP synthesis associated only with the dimeric form of ATP synthase; F1F0 ATP synthase subunit g 1532337 2892278 KLLA0_C17446g Kluyveromyces lactis F1F0 ATP synthase subunit g XP_452979.1 1531978 R 28985 CDS KLLA0_C17468g 2892021 complement(1532768..1534939) C 1 NC_006039.1 similar to uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane urea transporter expression is highly sensitive to nitrogen catabolite repression and induced by allophanate the last intermediate of the allantoin degradative pathway; uncharacterized protein 1534939 2892021 KLLA0_C17468g Kluyveromyces lactis uncharacterized protein XP_452980.1 1532768 R 28985 CDS KLLA0_C17490g 2892547 1536197..1537555 C 1 NC_006039.1 uniprot|Q70SJ1 Kluyveromyces lactis pcl1 Putative carboxypeptidase-related protein; uncharacterized protein 1537555 2892547 KLLA0_C17490g Kluyveromyces lactis uncharacterized protein XP_452981.1 1536197 D 28985 CDS KLLA0_C17512g 2891932 complement(1537707..1540385) C 1 NC_006039.1 highly similar to uniprot|P30665 Saccharomyces cerevisiae YPR019W CDC54 Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt the DNA prior to replication accumulates in the nucleus in G1 homolog of S. pombe Cdc21p; MCM DNA helicase complex subunit MCM4 1540385 2891932 KLLA0_C17512g Kluyveromyces lactis MCM DNA helicase complex subunit MCM4 XP_452982.1 1537707 R 28985 CDS KLLA0_C17534g 2892041 1540967..1543984 C 1 NC_006039.1 similar to uniprot|Q07830 Saccharomyces cerevisiae YLL031C; mannose-ethanolamine phosphotransferase GPI13 1543984 2892041 KLLA0_C17534g Kluyveromyces lactis mannose-ethanolamine phosphotransferase GPI13 XP_452983.1 1540967 D 28985 CDS KLLA0_C17556g 2891913 complement(1544404..1546227) C 1 NC_006039.1 highly similar to uniprot|Q03195 Saccharomyces cerevisiae YDR091C RLI1 Predicted ABC family ATPase required for translation initiation facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit may have a role in large ribosomal subunit biogenesis; Fe-S cluster-binding ribosome biosynthesis protein 1546227 2891913 KLLA0_C17556g Kluyveromyces lactis Fe-S cluster-binding ribosome biosynthesis protein XP_452984.1 1544404 R 28985 CDS KLLA0_C17578g 2892053 1547890..1552467 C 1 NC_006039.1 similar to uniprot|P32657 Saccharomyces cerevisiae YER164W CHD1 Sole S. cerevisiae member of CHD gene family containing Chromodomain Helicase domain and DNA-binding domain transcriptional regulator; chromatin-remodeling ATPase CHD1 1552467 2892053 KLLA0_C17578g Kluyveromyces lactis chromatin-remodeling ATPase CHD1 XP_452985.1 1547890 D 28985 CDS KLLA0_C17600g 2892135 1553322..1555100 C 1 NC_006039.1 similar to uniprot|P04147 Saccharomyces cerevisiae YER165W PAB1 Poly(A) binding protein part of the 3'-end RNA-processing complex mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail involved in control of poly(A) tail length interacts with translation factor eIF-4G; polyadenylate-binding protein 1555100 2892135 KLLA0_C17600g Kluyveromyces lactis polyadenylate-binding protein XP_452986.1 1553322 D 28985 CDS KLLA0_C17622g 2892070 join(1555873..1555902,1556004..1556453) C 1 NC_006039.1 highly similar to uniprot|P52490 Saccharomyces cerevisiae YDR092W UBC13 Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue DNA damage triggers redistribution from the cytoplasm to the nucleus; E2 ubiquitin-conjugating protein UBC13 1556453 2892070 KLLA0_C17622g Kluyveromyces lactis E2 ubiquitin-conjugating protein UBC13 XP_452987.1 1555873 D 28985 CDS KLLA0_C17644g 2892067 1557138..1561868 C 1 NC_006039.1 similar to uniprot|P32660 Saccharomyces cerevisiae YER166W DNF1 Non-essential P-type ATPase that is a potential aminophospholipid translocase localizes to the plasma membrane and late exocytic or early endocytic membranes likely involved in protein transport; aminophospholipid-translocating P4-type ATPase DNF1 1561868 2892067 KLLA0_C17644g Kluyveromyces lactis aminophospholipid-translocating P4-type ATPase DNF1 XP_452988.1 1557138 D 28985 CDS KLLA0_C17666g 2892103 1562996..1565368 C 1 NC_006039.1 some similarities with uniprot|P33306 Saccharomyces cerevisiae YER167W BCK2 Protein rich in serine and threonine residues involved in protein kinase C signaling pathway which controls cell integrity overproduction suppresses pkc1 mutations; uncharacterized protein 1565368 2892103 KLLA0_C17666g Kluyveromyces lactis uncharacterized protein XP_452989.1 1562996 D 28985 CDS KLLA0_C17688g 2892127 complement(1565906..1567375) C 1 NC_006039.1 uniprot|Q9HGK5 Kluyveromyces lactis CCA1 TRNA nucleotidyltransferase; tRNA adenylyltransferase 1567375 2892127 KLLA0_C17688g Kluyveromyces lactis tRNA adenylyltransferase XP_452990.1 1565906 R 28985 CDS KLLA0_C17710g 2892159 1569331..1571796 C 1 NC_006039.1 similar to uniprot|Q74ZT1 Ashbya gossypii AGR117C AGR117Cp and some similarites with YER169W uniprot|P39956 Saccharomyces cerevisiae YER169W RPH1 Transcriptional repressor of PHR1 which is a photolyase induced by DNA damage binds to AG(4) (C(4)T) sequence upstream of PHR1 Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; uncharacterized protein 1571796 2892159 KLLA0_C17710g Kluyveromyces lactis uncharacterized protein XP_452991.1 1569331 D 28985 CDS KLLA0_C17732g 2892098 complement(1572115..1575699) C 1 NC_006039.1 similar to uniprot|Q03834 Saccharomyces cerevisiae YDR097C MSH6 Protein required for mismatch repair in mitosis and meiosis forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs potentially phosphorylated by Cdc28p; mismatch repair ATPase MSH6 1575699 2892098 KLLA0_C17732g Kluyveromyces lactis mismatch repair ATPase MSH6 XP_452992.1 1572115 R 28985 CDS KLLA0_C17754g 2892158 1576357..1577040 C 1 NC_006039.1 similar to uniprot|P26364 Saccharomyces cerevisiae YER170W ADK2 Mitochondrial adenylate kinase catalyzes the reversible synthesis of GTP and AMP from GDP and ADP may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions 3' sequence of ADK2 varies with strain background; adenylate kinase ADK2 1577040 2892158 KLLA0_C17754g Kluyveromyces lactis adenylate kinase ADK2 XP_452993.1 1576357 D 28985 CDS KLLA0_C17776g 2892527 1577323..1579659 C 1 NC_006039.1 highly similar to uniprot|P06839 Saccharomyces cerevisiae YER171W RAD3 5' to 3' DNA helicase involved in nucleotide excision repair and transcription subunit of RNA polymerase II transcription initiation factor TFIIH subunit of Nucleotide Excision Repair Factor 3 (NEF3) homolog of human XPD protein; TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3 1579659 2892527 KLLA0_C17776g Kluyveromyces lactis TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3 XP_452994.1 1577323 D 28985 CDS KLLA0_C17798g 2892165 complement(1579752..1586201) C 1 NC_006039.1 similar to uniprot|P32639 Saccharomyces cerevisiae YER172C BRR2 RNA-dependent ATPase RNA helicase involved in the facilitation and disruption of snRNA interactions required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; ATP-dependent RNA helicase BRR2 1586201 2892165 KLLA0_C17798g Kluyveromyces lactis ATP-dependent RNA helicase BRR2 XP_452995.1 1579752 R 28985 CDS KLLA0_C17820g 2892074 1586564..1588510 C 1 NC_006039.1 similar to uniprot|P32641 Saccharomyces cerevisiae YER173W RAD24 Checkpoint protein involved in the activation of the DNA damage and meiotic pachytene checkpoints subunit of a clamp loader that loads Rad17p- Mec3p-Ddc1p onto DNA homolog of human and S. pombe Rad17 protein; uncharacterized protein 1588510 2892074 KLLA0_C17820g Kluyveromyces lactis uncharacterized protein XP_452996.1 1586564 D 28985 CDS KLLA0_C17842g 2892162 complement(1588951..1589745) C 1 NC_006039.1 similar to uniprot|Q03835 Saccharomyces cerevisiae YDR098C GRX3 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase monothiol glutaredoxin subfamily member along with Grx4p and Grx5p protects cells from oxidative damage; monothiol glutaredoxin GRX4 1589745 2892162 KLLA0_C17842g Kluyveromyces lactis monothiol glutaredoxin GRX4 XP_452997.1 1588951 R 28985 CDS KLLA0_C17864g 2892107 complement(1590736..1591629) C 1 NC_006039.1 similar to uniprot|P32643 Saccharomyces cerevisiae YER175C TMT1 Trans-aconitate methyltransferase; trans-aconitate 3-methyltransferase 1591629 2892107 KLLA0_C17864g Kluyveromyces lactis trans-aconitate 3-methyltransferase XP_452998.1 1590736 R 28985 CDS KLLA0_C17930g 2892217 join(1592949..1593089,1593200..1593823) C 1 NC_006039.1 weakly similar to uniprot|Q02721 Saccharomyces cerevisiae YLR329W; uncharacterized protein 1593823 2892217 KLLA0_C17930g Kluyveromyces lactis uncharacterized protein XP_452999.2 1592949 D 28985 CDS KLLA0_C17941g 2892020 complement(1593820..1594413) C 1 NC_006039.1 similar to uniprot|P53209 Saccharomyces cerevisiae YGR016W Hypothetical ORF; uncharacterized protein 1594413 2892020 KLLA0_C17941g Kluyveromyces lactis uncharacterized protein XP_453000.1 1593820 R 28985 CDS KLLA0_C17963g 2892036 1594915..1595838 C 1 NC_006039.1 similar to uniprot|P53208 Saccharomyces cerevisiae YGR015C Hypothetical ORF; uncharacterized protein 1595838 2892036 KLLA0_C17963g Kluyveromyces lactis uncharacterized protein XP_453001.1 1594915 D 28985 CDS KLLA0_C17985g 2891929 complement(1596320..1599046) C 1 NC_006039.1 some similarities with uniprot|P32334 Saccharomyces cerevisiae YGR014W MSB2 Mucin family member at the head of the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway also functions as an osmosensor in parallel to the Sho1p-mediated pathway potential Cdc28p substrate; uncharacterized protein 1599046 2891929 KLLA0_C17985g Kluyveromyces lactis uncharacterized protein XP_453002.1 1596320 R 28985 CDS KLLA0_C18007g 2892608 complement(1599968..1601674) C 1 NC_006039.1 weakly similar to uniprot|P53207 Saccharomyces cerevisiae YGR013W SNU71 associated with U1 snRNP (no counterpart in mammalian U1 snRNP contains few SR- RE- and RD-dipeptides U1 snRNP protein; uncharacterized protein 1601674 2892608 KLLA0_C18007g Kluyveromyces lactis uncharacterized protein XP_453003.1 1599968 R 28985 CDS KLLA0_C18029g 2891904 complement(1601829..1602983) C 1 NC_006039.1 similar to uniprot|P53206 Saccharomyces cerevisiae YGR012W Hypothetical ORF; uncharacterized protein 1602983 2891904 KLLA0_C18029g Kluyveromyces lactis uncharacterized protein XP_453004.1 1601829 R 28985 CDS KLLA0_C18051g 2892141 complement(1603208..1604557) C 1 NC_006039.1 highly similar to uniprot|Q06178 Saccharomyces cerevisiae YLR328W NMA1 Nicotinic acid mononucleotide adenylyltransferase involved in NAD() salvage pathway; nicotinamide-nucleotide adenylyltransferase NMA2 1604557 2892141 KLLA0_C18051g Kluyveromyces lactis nicotinamide-nucleotide adenylyltransferase NMA2 XP_453005.1 1603208 R 28985 CDS KLLA0_C18117g 2892117 1605788..1606012 C 1 NC_006039.1 similar to uniprot|Q06177 Saccharomyces cerevisiae YLR327C RBF9 Hypothetical ORF; uncharacterized protein 1606012 2892117 KLLA0_C18117g Kluyveromyces lactis uncharacterized protein XP_453006.1 1605788 D 28985 CDS KLLA0_C18139g 2891850 complement(1606193..1607119) C 1 NC_006039.1 similar to uniprot|P33412 YGR007W Saccharomyces cerevisiae MUQ1 Choline phosphate cytidylyltransferase; ethanolamine-phosphate cytidylyltransferase 1607119 2891850 KLLA0_C18139g Kluyveromyces lactis ethanolamine-phosphate cytidylyltransferase XP_453007.1 1606193 R 28985 CDS KLLA0_C18161g 2892575 complement(1607267..1607968) C 1 NC_006039.1 similar to uniprot|Q06170 Saccharomyces cerevisiae YLR326W Hypothetical ORF; uncharacterized protein 1607968 2892575 KLLA0_C18161g Kluyveromyces lactis uncharacterized protein XP_453008.2 1607267 R 28985 CDS KLLA0_C18172g 2892216 complement(1608010..1608468) C 1 NC_006039.1 some similarities with uniprot|P33411 Saccharomyces cerevisiae YGR006W PRP18 Splicing factor involved in the positioning of the 3' splice site during the second catalytic step of splicing recruited to the spliceosome by Slu7p; mRNA splicing protein PRP18 1608468 2892216 KLLA0_C18172g Kluyveromyces lactis mRNA splicing protein PRP18 XP_453009.1 1608010 R 28985 CDS KLLA0_C18194g 2891991 1608722..1609888 C 1 NC_006039.1 similar to uniprot|P41896 Saccharomyces cerevisiae YGR005C TFG2 transcription initiation factor TFIIF middle subunit; transcription factor IIF subunit TFG2 1609888 2891991 KLLA0_C18194g Kluyveromyces lactis transcription factor IIF subunit TFG2 XP_453010.1 1608722 D 28985 CDS KLLA0_C18216g 2892095 1610542..1610778 C 1 NC_006039.1 highly similar to uniprot|P49167 Saccharomyces cerevisiae YLR325C RPL38 Protein component of the large (60S) ribosomal subunit; 60S ribosomal protein eL38 1610778 2892095 KLLA0_C18216g Kluyveromyces lactis 60S ribosomal protein eL38 XP_453011.1 1610542 D 28985 CDS KLLA0_C18238g 2892526 complement(1611376..1612956) C 1 NC_006039.1 similar to uniprot|Q06169 Saccharomyces cerevisiae YLR324W PEX30 Peroxisomal integral membrane protein involved in negative regulation of peroxisome number partially functionally redundant with Pex31p genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p; uncharacterized protein 1612956 2892526 KLLA0_C18238g Kluyveromyces lactis uncharacterized protein XP_453012.1 1611376 R 28985 CDS KLLA0_C18260g 2891847 1613311..1614000 C 1 NC_006039.1 similar to uniprot|Q752S4 Ashbya gossypii AFR499C CWC24 Pre-mRNA-splicing factor CWC24 and some similarites with YLR323C uniprot|P53769 Saccharomyces cerevisiae; U2-type spliceosomal complex subunit CWC24 1614000 2891847 KLLA0_C18260g Kluyveromyces lactis U2-type spliceosomal complex subunit CWC24 XP_453013.1 1613311 D 28985 CDS KLLA0_C18282g 2892168 complement(1614045..1616252) C 1 NC_006039.1 similar to uniprot|P53202 Saccharomyces cerevisiae YGR003W; cullin CUL3 1616252 2892168 KLLA0_C18282g Kluyveromyces lactis cullin CUL3 XP_453014.1 1614045 R 28985 CDS KLLA0_C18315g 2892076 1616549..1618042 C 1 NC_006039.1 similar to uniprot|Q752S6 Ashbya gossypii AFR497C SWC4 SWR1-complex protein 4 and weakly similar to YGR002C uniprot|P53201 Saccharomyces cerevisiae YGR002C SWC4 Protein of unknown function component of the Swr1p complex that incorporates Htz1p into chromatin component of the NuA4 histone acetyltransferase complex; uncharacterized protein 1618042 2892076 KLLA0_C18315g Kluyveromyces lactis uncharacterized protein XP_453016.1 1616549 D 28985 CDS KLLA0_C18337g 2892057 complement(1618091..1622449) C 1 NC_006039.1 weakly similar to uniprot|Q06164 Saccharomyces cerevisiae YLR320W MMS22 Protein involved in resistance to ionizing radiation acts with Mms1p in a repair pathway that may be involved in resolving replication intermediates or preventing the damage caused by blocked replication forks; uncharacterized protein 1622449 2892057 KLLA0_C18337g Kluyveromyces lactis uncharacterized protein XP_453017.1 1618091 R 28985 CDS KLLA0_C18359g 2892064 1622747..1624840 C 1 NC_006039.1 similar to uniprot|P41697 Saccharomyces cerevisiae YLR319C BUD6 Actin- and formin-interacting protein involved in actin cable nucleation and polarized cell growth isolated as bipolar budding mutant potential Cdc28p substrate; uncharacterized protein 1624840 2892064 KLLA0_C18359g Kluyveromyces lactis uncharacterized protein XP_453018.1 1622747 D 28985 CDS KLLA0_C18381g 2892195 complement(1624865..1627450) C 1 NC_006039.1 similar to uniprot|Q06163 Saccharomyces cerevisiae YLR318W EST2 Reverse transcriptase subunit of the telomerase holoenzyme essential for telomerase core catalytic activity involved in other aspects of telomerase assembly and function; telomerase reverse transcriptase 1627450 2892195 KLLA0_C18381g Kluyveromyces lactis telomerase reverse transcriptase XP_453019.1 1624865 R 28985 CDS KLLA0_C18403g 2892142 1627733..1628719 C 1 NC_006039.1 similar to uniprot|Q9URQ3 Saccharomyces cerevisiae YLR316C TAD3 tRNA-specific adenosine-34 deaminase subunit Tad3p; uncharacterized protein 1628719 2892142 KLLA0_C18403g Kluyveromyces lactis uncharacterized protein XP_453020.1 1627733 D 28985 CDS KLLA0_C18425g 2892138 complement(1628725..1629180) C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 1629180 2892138 KLLA0_C18425g Kluyveromyces lactis uncharacterized protein XP_453021.1 1628725 R 28985 CDS KLLA0_C18447g 2892289 complement(1629477..1630805) C 1 NC_006039.1 similar to uniprot|Q06168 Saccharomyces cerevisiae YLR321C SFH1 Involved in chromatin modeling cell cycle progression homolog of Snf5p member of the chromatin remodeling complex RSC; uncharacterized protein 1630805 2892289 KLLA0_C18447g Kluyveromyces lactis uncharacterized protein XP_453022.1 1629477 R 28985 CDS KLLA0_C18469g 2892272 join(1631528..1631607,1631898..1632441) C 1 NC_006039.1 highly similar to uniprot|P32471 Saccharomyces cerevisiae YAL003W EFB1 Translation elongation factor 1 beta; translation elongation factor 1 subunit beta 1632441 2892272 KLLA0_C18469g Kluyveromyces lactis translation elongation factor 1 subunit beta XP_453023.1 1631528 D 28985 CDS KLLA0_C18491g 2892104 1632791..1636387 C 1 NC_006039.1 similar to uniprot|P39702 Saccharomyces cerevisiae YAL002W VPS8 involved in vacuolar protein sorting required for localization and trafficking of the CPY sorting receptor Vps8p is a membrane-associated hydrophilic protein which contains a C-terminal cysteine-rich region that conforms to the H2 variant of the RING finger Zn2 binding motif.; CORVET complex membrane-binding subunit VPS8 1636387 2892104 KLLA0_C18491g Kluyveromyces lactis CORVET complex membrane-binding subunit VPS8 XP_453024.1 1632791 D 28985 CDS KLLA0_C18513g 2892102 complement(1636434..1637489) C 1 NC_006039.1 highly similar to uniprot|P53199 Saccharomyces cerevisiae YGL001C ERG26 C-3 sterol dehydrogenase catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) 1637489 2892102 KLLA0_C18513g Kluyveromyces lactis sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) XP_453025.1 1636434 R 28985 CDS KLLA0_C18546g 2891967 1638916..1639314 C 1 NC_006039.1 highly similar to uniprot|P53738 YNR046W Saccharomyces cerevisiae TRM112 Protein required for cell viability; RNA methylation protein TRM112 1639314 2891967 KLLA0_C18546g Kluyveromyces lactis RNA methylation protein TRM112 XP_453026.1 1638916 D 28985 CDS KLLA0_C18568g 2892629 1639958..1642282 C 1 NC_006039.1 similar to uniprot|P53739 Saccharomyces cerevisiae YNR047W Putative protein kinase that when overexpressed interferes with pheromone-induced growth arrest localizes to the cytoplasm potential Cdc28p substrate and to YCR091W uniprot|P25341 Saccharomyces cerevisiae YCR091W KIN82 Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily; uncharacterized protein 1642282 2892629 KLLA0_C18568g Kluyveromyces lactis uncharacterized protein XP_453027.1 1639958 D 28985 CDS KLLA0_C18590g 2892153 complement(1642291..1645380) C 1 NC_006039.1 similar to uniprot|P25336 Saccharomyces cerevisiae YCR092C MSH3 Mismatch repair protein forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends contains a PCNA (Pol30p) binding motif required for genome stability; mismatch repair protein MSH3 1645380 2892153 KLLA0_C18590g Kluyveromyces lactis mismatch repair protein MSH3 XP_453028.1 1642291 R 28985 CDS KLLA0_C18612g 2892144 1646511..1652933 C 1 NC_006039.1 similar to uniprot|P25655 YCR093W Saccharomyces cerevisiae CDC39 Component of the CCR4-NOT complex regulating mRNA levels; CCR4-NOT core subunit CDC39 1652933 2892144 KLLA0_C18612g Kluyveromyces lactis CCR4-NOT core subunit CDC39 XP_453029.1 1646511 D 28985 CDS KLLA0_C18634g 2892147 1653295..1654455 C 1 NC_006039.1 similar to uniprot|P25656 Saccharomyces cerevisiae YCR094W CDC50 Endosomal protein that regulates cell polarity; uncharacterized protein 1654455 2892147 KLLA0_C18634g Kluyveromyces lactis uncharacterized protein XP_453030.1 1653295 D 28985 CDS KLLA0_C18656g 2892155 1654787..1655473 C 1 NC_006039.1 highly similar to uniprot|P21734 Saccharomyces cerevisiae YDR177W UBC1 Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD) component of the cellular stress response; E2 ubiquitin-conjugating protein UBC1 1655473 2892155 KLLA0_C18656g Kluyveromyces lactis E2 ubiquitin-conjugating protein UBC1 XP_453031.1 1654787 D 28985 CDS KLLA0_C18678g 2892564 complement(1655735..1657387) C 1 NC_006039.1 similar to uniprot|Q12235 Saccharomyces cerevisiae YLL055W Hypothetical ORF; uncharacterized protein 1657387 2892564 KLLA0_C18678g Kluyveromyces lactis uncharacterized protein XP_453032.1 1655735 R 28985 CDS KLLA0_C18700g 2892472 complement(1658267..1662133) C 1 NC_006039.1 similar to uniprot|P28273 YKL215C Saccharomyces cerevisiae Hypothetical ORF; uncharacterized protein 1662133 2892472 KLLA0_C18700g Kluyveromyces lactis uncharacterized protein XP_453033.1 1658267 R 28985 CDS KLLA0_C18711g 9487465 1662320..1662484 C 1 NC_006039.1 no similarity; uncharacterized protein 1662484 9487465 KLLA0_C18711g Kluyveromyces lactis uncharacterized protein XP_002999362.1 1662320 D 28985 CDS KLLA0_C18722g 2892525 complement(1662508..1663107) C 1 NC_006039.1 similar to uniprot|Q9UVP9 Saccharomyces kluyveri Hypothetical protein and some similarites with YNR049C uniprot|P53604 Saccharomyces cerevisiae YNR049C MSO1 Probable component of the secretory vesicle docking complex acts at a late step in secretion shows genetic and physical interactions with Sec1p and is enriched in microsomal membrane fractions required for sporulation; uncharacterized protein 1663107 2892525 KLLA0_C18722g Kluyveromyces lactis uncharacterized protein XP_453034.1 1662508 R 28985 CDS KLLA0_C18744g 2892518 complement(1663510..1664847) C 1 NC_006039.1 highly similar to uniprot|P38999 YNR050C Saccharomyces cerevisiae LYS9 Saccharopine dehydrogenase (NADP L- glutamate-forming); saccharopine dehydrogenase (NADP+, L-glutamate-forming) 1664847 2892518 KLLA0_C18744g Kluyveromyces lactis saccharopine dehydrogenase (NADP+, L-glutamate-forming) XP_453035.1 1663510 R 28985 CDS KLLA0_C18755g 2892304 1664912..1665268 C 1 NC_006039.1 no similarity; uncharacterized protein 1665268 2892304 KLLA0_C18755g Kluyveromyces lactis uncharacterized protein XP_453036.1 1664912 D 28985 CDS KLLA0_C18777g 2892109 complement(1665876..1666901) C 1 NC_006039.1 similar to uniprot|P25366 Saccharomyces cerevisiae YCR095C Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; uncharacterized protein 1666901 2892109 KLLA0_C18777g Kluyveromyces lactis uncharacterized protein XP_453037.1 1665876 R 28985 CDS KLLA0_C18799g 2892556 complement(1667314..1668795) C 1 NC_006039.1 some similarities with uniprot|P53741 YNR051C Saccharomyces cerevisiae BRE5 Ubiquitin protease cofactor; uncharacterized protein 1668795 2892556 KLLA0_C18799g Kluyveromyces lactis uncharacterized protein XP_453038.1 1667314 R 28985 CDS KLLA0_C18821g 2892654 complement(1669647..1670990) C 1 NC_006039.1 similar to uniprot|P39008 YNR052C Saccharomyces cerevisiae POP2 RNase of the DEDD superfamily subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation; CCR4-NOT core DEDD family RNase subunit POP2 1670990 2892654 KLLA0_C18821g Kluyveromyces lactis CCR4-NOT core DEDD family RNase subunit POP2 XP_453039.1 1669647 R 28985 CDS KLLA0_C18843g 2892114 complement(join(1671445..1672179,1672660..1673466)) C 1 NC_006039.1 highly similar to uniprot|P53742 Saccharomyces cerevisiae YNR053C NOG2 Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation; uncharacterized protein 1673466 2892114 KLLA0_C18843g Kluyveromyces lactis uncharacterized protein XP_453040.1 1671445 R 28985 CDS KLLA0_C18865g 2892281 complement(1673836..1674717) C 1 NC_006039.1 some similarities with uniprot|P53743 YNR054C Saccharomyces cerevisiae ESF2 Essential nucleolar protein involved in pre-18S rRNA processing; RNA-binding ATPase activator ESF2 1674717 2892281 KLLA0_C18865g Kluyveromyces lactis RNA-binding ATPase activator ESF2 XP_453041.1 1673836 R 28985 CDS KLLA0_C18887g 2891849 1675383..1676435 C 1 NC_006039.1 similar to uniprot|Q04869 Saccharomyces cerevisiae YMR315W Hypothetical ORF; uncharacterized protein 1676435 2891849 KLLA0_C18887g Kluyveromyces lactis uncharacterized protein XP_453042.1 1675383 D 28985 CDS KLLA0_C18909g 2892132 complement(1676552..1678630) C 1 NC_006039.1 similar to uniprot|Q59UP3 Candida albicans DUR34 Potential urea active transport protein and weakly similar to YHL016C uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane urea transporter expression is highly sensitive to nitrogen catabolite repression and induced by allophanate the last intermediate of the allantoin degradative pathway; uncharacterized protein 1678630 2892132 KLLA0_C18909g Kluyveromyces lactis uncharacterized protein XP_453043.1 1676552 R 28985 CDS KLLA0_C18931g 2892277 1680133..1681794 C 1 NC_006039.1 uniprot|Q874B4 Kluyveromyces lactis KLLA0C18931g Drug efflux permease KNQ1; uncharacterized protein 1681794 2892277 KLLA0_C18931g Kluyveromyces lactis uncharacterized protein XP_453044.1 1680133 D 28985 CDS KLLA0_C18953g 2892177 1682246..1684357 C 1 NC_006039.1 some similarities with uniprot|P25502 Saccharomyces cerevisiae YKL015W PUT3 Positive regulator of PUT (proline utilization) genes zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; uncharacterized protein 1684357 2892177 KLLA0_C18953g Kluyveromyces lactis uncharacterized protein XP_453045.1 1682246 D 28985 CDS KLLA0_C18975g 2892188 complement(1684573..1688433) C 1 NC_006039.1 highly similar to uniprot|P28273 YKL215C Saccharomyces cerevisiae Hypothetical ORF; 5-oxoprolinase 1688433 2892188 KLLA0_C18975g Kluyveromyces lactis 5-oxoprolinase XP_453046.1 1684573 R 28985 CDS KLLA0_C18997g 2892193 complement(1688974..1689318) C 1 NC_006039.1 no similarity; uncharacterized protein 1689318 2892193 KLLA0_C18997g Kluyveromyces lactis uncharacterized protein XP_453047.1 1688974 R 28985 CDS KLLA0_C19019g 2892182 1689555..1691090 C 1 NC_006039.1 similar to uniprot|P53322 Saccharomyces cerevisiae YGR260W TNA1 High affinity nicotinic acid plasma membrane permease; uncharacterized protein 1691090 2892182 KLLA0_C19019g Kluyveromyces lactis uncharacterized protein XP_453048.1 1689555 D 28985 CDS KLLA0_C19041g 2892089 complement(1691258..1692091) C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 1692091 2892089 KLLA0_C19041g Kluyveromyces lactis uncharacterized protein XP_453049.1 1691258 R 28985 CDS KLLA0_C19063g 2892055 complement(1692492..1693121) C 1 NC_006039.1 conserved hypothetical protein; uncharacterized protein 1693121 2892055 KLLA0_C19063g Kluyveromyces lactis uncharacterized protein XP_453050.1 1692492 R 28985 CDS KLLA0_C19085g 2892087 complement(1694739..1695761) C 1 NC_006039.1 highly similar to uniprot|Q07748 Saccharomyces cerevisiae YDL244W THI13 Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP) member of a subtelomeric gene family including THI5 THI11 THI12 and THI13; uncharacterized protein 1695761 2892087 KLLA0_C19085g Kluyveromyces lactis uncharacterized protein XP_453051.1 1694739 R 28985 CDS KLLA0_C19107g 2892062 complement(1696925..1698556) C 1 NC_006039.1 weakly similar to uniprot|P32375 Saccharomyces cerevisiae YIR027C DAL1 Allantoinase converts allantoin to allantoate in the first step of allantoin degradation expression sensitive to nitrogen catabolite repression; uncharacterized protein 1698556 2892062 KLLA0_C19107g Kluyveromyces lactis uncharacterized protein XP_453052.1 1696925 R 28985 CDS KLLA0_C19132g 9487449 1699729..1699998 C 1 NC_006039.1 no similarity; uncharacterized protein 1699998 9487449 KLLA0_C19132g Kluyveromyces lactis uncharacterized protein XP_002999363.1 1699729 D 28985 CDS KLLA0_C19184g 2892648 1709494..1710936 C 1 NC_006039.1 no similarity; uncharacterized protein 1710936 2892648 KLLA0_C19184g Kluyveromyces lactis uncharacterized protein XP_453056.1 1709494 D 28985 CDS KLLA0_C19206g 2892619 1711813..1713348 C 1 NC_006039.1 similar to uniprot|Q5MBU0 Aspergillus fumigatus gliC GliC; uncharacterized protein 1713348 2892619 KLLA0_C19206g Kluyveromyces lactis uncharacterized protein XP_453057.1 1711813 D 28985 CDS KLLA0_C19228g 2892646 1713787..1715562 C 1 NC_006039.1 similar to uniprot|P53749 Saccharomyces cerevisiae YNR063W Hypothetical ORF; uncharacterized protein 1715562 2892646 KLLA0_C19228g Kluyveromyces lactis uncharacterized protein XP_453058.1 1713787 D 28985 CDS KLLA0_C19250g 2892210 1716088..1717470 C 1 NC_006039.1 similar to uniprot|P53748 Saccharomyces cerevisiae YNR062C Hypothetical ORF; uncharacterized protein 1717470 2892210 KLLA0_C19250g Kluyveromyces lactis uncharacterized protein XP_453059.1 1716088 D 28985 CDS KLLA0_C19272g 2892638 complement(1717903..1719774) C 1 NC_006039.1 similar to uniprot|P38724 Saccharomyces cerevisiae YHL047C ARN2 Transporter or YHL040C uniprot|P38731 Saccharomyces cerevisiae YHL040C ARN1 Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates responsible for uptake of iron bound to the siderophore triacetylfusarinine C; uncharacterized protein 1719774 2892638 KLLA0_C19272g Kluyveromyces lactis uncharacterized protein XP_453060.1 1717903 R 28985 CDS KLLA0_C19316g 2892214 1722987..1725086 C 1 NC_006039.1 some similarities with uniprot|P39712 Saccharomyces cerevisiae YAL063C; uncharacterized protein 1725086 2892214 KLLA0_C19316g Kluyveromyces lactis uncharacterized protein XP_453062.1 1722987 D 28985 CDS KLLA0_C19327g 9487426 complement(join(1727158..1727508,1727595..1727597)) C 1 NC_006039.1 some similarities with uniprot|P53054 Saccharomyces cerevisiae YGL262W Hypothetical ORF; uncharacterized protein 1727597 9487426 KLLA0_C19327g Kluyveromyces lactis uncharacterized protein XP_002999364.1 1727158 R 28985 CDS KLLA0_C19338g 2891938 1729569..1730978 C 1 NC_006039.1 similar to uniprot|P24031 Saccharomyces cerevisiae YBR092C PHO3 Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin; uncharacterized protein 1730978 2891938 KLLA0_C19338g Kluyveromyces lactis uncharacterized protein XP_453063.1 1729569 D 28985 CDS KLLA0_C19360g 2891827 complement(1731276..1732223) C 1 NC_006039.1 highly similar to uniprot|P28272 Saccharomyces cerevisiae YKL216W URA1 The enzyme catalyzes the conversion of dihydroorotic acid to orotic acid dihydroorotate dehydrogenase; dihydroorotate dehydrogenase 1732223 2891827 KLLA0_C19360g Kluyveromyces lactis dihydroorotate dehydrogenase XP_453064.1 1731276 R 28985 CDS KLLA0_C19382g 2892301 complement(1733084..1734340) C 1 NC_006039.1 similar to uniprot|P10127 Saccharomyces cerevisiae YGL256W; alcohol dehydrogenase ADH4 1734340 2892301 KLLA0_C19382g Kluyveromyces lactis alcohol dehydrogenase ADH4 XP_453065.1 1733084 R 28985 CDS KLLA0_C19437g 2892677 1740718..1743105 C 1 NC_006039.1 some similarities with uniprot|P08640 Saccharomyces cerevisiae YIR019C MUC1 GPI-anchored cell surface glycoprotein required for diploid pseudohyphal formation and haploid invasive growth transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p); uncharacterized protein 1743105 2892677 KLLA0_C19437g Kluyveromyces lactis uncharacterized protein XP_453068.1 1740718 D 28985 CDS KLLA0_C19547g 2892609 1750548..1751549 C 1 NC_006039.1 weakly similar to uniprot|Q55924 Synechocystis sp slr0317 Slr0317 protein; uncharacterized protein 1751549 2892609 KLLA0_C19547g Kluyveromyces lactis uncharacterized protein XP_453073.1 1750548 D 28985 CDS KLLA0_D00143g 2893391 4326..5849 D 1 NC_006040.1 similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport; uncharacterized protein 5849 2893391 KLLA0_D00143g Kluyveromyces lactis uncharacterized protein XP_453077.1 4326 D 28985 CDS KLLA0_D00157g 9487371 complement(6536..6754) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 6754 9487371 KLLA0_D00157g Kluyveromyces lactis uncharacterized protein XP_002999365.1 6536 R 28985 CDS KLLA0_D00187g 2893130 7837..8277 D 1 NC_006040.1 no similarity; uncharacterized protein 8277 2893130 KLLA0_D00187g Kluyveromyces lactis uncharacterized protein XP_453079.2 7837 D 28985 CDS KLLA0_D00209g 2892849 complement(8764..9141) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 9141 2892849 KLLA0_D00209g Kluyveromyces lactis uncharacterized protein XP_453080.2 8764 R 28985 CDS KLLA0_D00231g 2893072 complement(9854..11626) D 1 NC_006040.1 uniprot|Q9Y844 Kluyveromyces lactis mal22 Maltase; uncharacterized protein 11626 2893072 KLLA0_D00231g Kluyveromyces lactis uncharacterized protein XP_453081.2 9854 R 28985 CDS KLLA0_D00253g 2892879 12804..14534 D 1 NC_006040.1 highly similar to uniprot|Q9Y845 Kluyveromyces lactis mal21 Maltose permease; uncharacterized protein 14534 2892879 KLLA0_D00253g Kluyveromyces lactis uncharacterized protein XP_453082.2 12804 D 28985 CDS KLLA0_D00258g 9487511 complement(15217..16671) D 1 NC_006040.1 similar to uniprot|P24031 Saccharomyces cerevisiae YBR092C PHO3 Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin; uncharacterized protein 16671 9487511 KLLA0_D00258g Kluyveromyces lactis uncharacterized protein XP_002999366.1 15217 R 28985 CDS KLLA0_D00264g 9487307 complement(18273..21287) D 1 NC_006040.1 some similarities with uniprot|P39712 Saccharomyces cerevisiae YAL063C; uncharacterized protein 21287 9487307 KLLA0_D00264g Kluyveromyces lactis uncharacterized protein XP_002999367.1 18273 R 28985 CDS KLLA0_D00269g 9487434 complement(22009..22491) D 1 NC_006040.1 no similarity; uncharacterized protein 22491 9487434 KLLA0_D00269g Kluyveromyces lactis uncharacterized protein XP_002999368.1 22009 R 28985 CDS KLLA0_D00275g 2893125 complement(24448..25623) D 1 NC_006040.1 some similarities with uniprot|P39712 Saccharomyces cerevisiae YAL063C; uncharacterized protein 25623 2893125 KLLA0_D00275g Kluyveromyces lactis uncharacterized protein XP_453083.1 24448 R 28985 CDS KLLA0_D00330g 2892773 complement(26976..29273) D 1 NC_006040.1 similar to uniprot|P07337 Kluyveromyces marxianus Beta- glucosidase precursor; uncharacterized protein 29273 2892773 KLLA0_D00330g Kluyveromyces lactis uncharacterized protein XP_453086.1 26976 R 28985 CDS KLLA0_D00352g 2892854 complement(29820..30341) D 1 NC_006040.1 no similarity; uncharacterized protein 30341 2892854 KLLA0_D00352g Kluyveromyces lactis uncharacterized protein XP_453087.1 29820 R 28985 CDS KLLA0_D00374g 2892800 30962..32632 D 1 NC_006040.1 similar to gnl|GLV|DEHA0G07139g Debaryomyces hansenii DEHA0G07139g and weakly similar to uniprot|P32466 Saccharomyces cerevisiae YDR345C HXT3 Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions; uncharacterized protein 32632 2892800 KLLA0_D00374g Kluyveromyces lactis uncharacterized protein XP_453088.1 30962 D 28985 CDS KLLA0_D00396g 2892888 complement(36277..37362) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 37362 2892888 KLLA0_D00396g Kluyveromyces lactis uncharacterized protein XP_453089.1 36277 R 28985 CDS KLLA0_D00418g 2893288 38504..39238 D 1 NC_006040.1 some similarities with uniprot|P32800 Saccharomyces cerevisiae YJL210W PEX2 RING-finger peroxin, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms putative translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import; ubiquitin-protein ligase peroxin 2 39238 2893288 KLLA0_D00418g Kluyveromyces lactis ubiquitin-protein ligase peroxin 2 XP_453090.1 38504 D 28985 CDS KLLA0_D00440g 2893438 complement(39291..40289) D 1 NC_006040.1 similar to uniprot|P08466 Saccharomyces cerevisiae YJL208C NUC1 Major mitochondrial nuclease has RNAse and DNA endo- and exonucleolytic activities has a role in mitochondrial recombination; ribonuclease 40289 2893438 KLLA0_D00440g Kluyveromyces lactis ribonuclease XP_453091.1 39291 R 28985 CDS KLLA0_D00462g 2893203 41415..43202 D 1 NC_006040.1 similar to uniprot|P05066 Saccharomyces cerevisiae YOR386W PHR1 DNA photolyase involved in photoreactivation repairs pyrimidine dimers in the presence of visible light induced by DNA damage regulated by transcriptional repressor Rph1p; deoxyribodipyrimidine photo-lyase PHR1 43202 2893203 KLLA0_D00462g Kluyveromyces lactis deoxyribodipyrimidine photo-lyase PHR1 XP_453092.1 41415 D 28985 CDS KLLA0_D00484g 2893578 44879..47893 D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 47893 2893578 KLLA0_D00484g Kluyveromyces lactis uncharacterized protein XP_453093.1 44879 D 28985 CDS KLLA0_D00506g 2892779 complement(48092..49318) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 49318 2892779 KLLA0_D00506g Kluyveromyces lactis uncharacterized protein XP_453094.1 48092 R 28985 CDS KLLA0_D00528g 2893313 51518..54526 D 1 NC_006040.1 similar to uniprot|Q75C89 Ashbya gossypii ACR027C ACR027Cp and some similarities with uniprot|P28273 YKL215C Saccharomyces cerevisiae Hypothetical ORF; uncharacterized protein 54526 2893313 KLLA0_D00528g Kluyveromyces lactis uncharacterized protein XP_453095.1 51518 D 28985 CDS KLLA0_D00550g 2893316 complement(55088..56827) D 1 NC_006040.1 weakly similar to uniprot|Q08579 YOR192C Saccharomyces cerevisiae Hypothetical ORF; uncharacterized protein 56827 2893316 KLLA0_D00550g Kluyveromyces lactis uncharacterized protein XP_453096.1 55088 R 28985 CDS KLLA0_D00572g 2892883 complement(57285..57704) D 1 NC_006040.1 some similarities with uniprot|Q12090 Saccharomyces cerevisiae YLR107W REX3 RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases; uncharacterized protein 57704 2892883 KLLA0_D00572g Kluyveromyces lactis uncharacterized protein XP_453097.1 57285 R 28985 CDS KLLA0_D00594g 2893296 complement(57894..58856) D 1 NC_006040.1 highly similar to uniprot|P41819 Saccharomyces cerevisiae YPL266W DIM1 Essential 18S rRNA dimethylase responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18 S rRNA part of 90S and 40S pre-particles in nucleolus involved in pre-ribosomal RNA processing; uncharacterized protein 58856 2893296 KLLA0_D00594g Kluyveromyces lactis uncharacterized protein XP_453098.1 57894 R 28985 CDS KLLA0_D00616g 2892987 complement(59155..59844) D 1 NC_006040.1 similar to uniprot|Q08981 Saccharomyces cerevisiae YPL267W ACM1 Protein of unknown function potential Cdc28p substrate; uncharacterized protein 59844 2892987 KLLA0_D00616g Kluyveromyces lactis uncharacterized protein XP_453099.1 59155 R 28985 CDS KLLA0_D00638g 2892722 complement(60190..63120) D 1 NC_006040.1 similar to uniprot|Q75C92 Ashbya gossypii ACR024W ACR024Wp and weakly similar to YPL268W uniprot|P32383 Saccharomyces cerevisiae YPL268W PLC1 Phosphoinositide-specific phospholipase C hydrolyzes phosphatidylinositol 4 5-biphosphate (PIP2) to generate inositol 1 4 5-triphosphate (IP3) and 1 2-diacylglycerol (DAG) involved in kinetochore function and pseudohyphal differentiation; phosphatidylinositol phospholipase C 63120 2892722 KLLA0_D00638g Kluyveromyces lactis phosphatidylinositol phospholipase C XP_453100.1 60190 R 28985 CDS KLLA0_D00660g 2893524 63920..64846 D 1 NC_006040.1 no similarity; uncharacterized protein 64846 2893524 KLLA0_D00660g Kluyveromyces lactis uncharacterized protein XP_453101.1 63920 D 28985 CDS KLLA0_D00682g 2893413 65058..65771 D 1 NC_006040.1 highly similar to uniprot|Q04432 Saccharomyces cerevisiae YDR533C; uncharacterized protein 65771 2893413 KLLA0_D00682g Kluyveromyces lactis uncharacterized protein XP_453102.1 65058 D 28985 CDS KLLA0_D00704g 2893218 66841..67554 D 1 NC_006040.1 highly similar to uniprot|Q04432 Saccharomyces cerevisiae YDR533C; uncharacterized protein 67554 2893218 KLLA0_D00704g Kluyveromyces lactis uncharacterized protein XP_453103.1 66841 D 28985 CDS KLLA0_D00726g 2893321 complement(67744..69450) D 1 NC_006040.1 weakly similar to uniprot|P32526 Saccharomyces cerevisiae YPL269W KAR9 Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase; uncharacterized protein 69450 2893321 KLLA0_D00726g Kluyveromyces lactis uncharacterized protein XP_453104.1 67744 R 28985 CDS KLLA0_D00748g 2893314 complement(69839..72208) D 1 NC_006040.1 similar to uniprot|P33311 Saccharomyces cerevisiae YPL270W MDL2 Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane; ATP-binding cassette permease MDL2 72208 2893314 KLLA0_D00748g Kluyveromyces lactis ATP-binding cassette permease MDL2 XP_453105.1 69839 R 28985 CDS KLLA0_D00792g 2893063 73422..76484 D 1 NC_006040.1 similar to uniprot|P39985 Saccharomyces cerevisiae YEL055C; DNA-directed DNA polymerase 76484 2893063 KLLA0_D00792g Kluyveromyces lactis DNA-directed DNA polymerase XP_453107.1 73422 D 28985 CDS KLLA0_D00814g 2892824 complement(76687..77913) D 1 NC_006040.1 similar to uniprot|P39984 Saccharomyces cerevisiae YEL056W; uncharacterized protein 77913 2892824 KLLA0_D00814g Kluyveromyces lactis uncharacterized protein XP_453108.1 76687 R 28985 CDS KLLA0_D00836g 2893255 complement(78202..80124) D 1 NC_006040.1 similar to uniprot|Q08979 Saccharomyces cerevisiae YPL263C KEL3 Cytoplasmic protein of unknown function; uncharacterized protein 80124 2893255 KLLA0_D00836g Kluyveromyces lactis uncharacterized protein XP_453109.1 78202 R 28985 CDS KLLA0_D00858g 2893051 complement(80327..81952) D 1 NC_006040.1 similar to uniprot|P38628 Saccharomyces cerevisiae YEL058W PCM1 Essential N-acetylglucosamine-phosphate mutase a hexosephosphate mutase involved in the biosynthesis of chitin; phosphoacetylglucosamine mutase PCM1 81952 2893051 KLLA0_D00858g Kluyveromyces lactis phosphoacetylglucosamine mutase PCM1 XP_453110.1 80327 R 28985 CDS KLLA0_D00880g 2892775 82211..82426 D 1 NC_006040.1 uniprot|P78699 Kluyveromyces lactis KLLA0D00880g SOM1 Protein SOM1 mitochondrial precursor; uncharacterized protein 82426 2892775 KLLA0_D00880g Kluyveromyces lactis uncharacterized protein XP_453111.1 82211 D 28985 CDS KLLA0_D00902g 2893546 83648..85126 D 1 NC_006040.1 highly similar to uniprot|P08417 Saccharomyces cerevisiae YPL262W FUM1 Fumarase converts fumaric acid to L-malic acid in the TCA cycle cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; fumarase FUM1 85126 2893546 KLLA0_D00902g Kluyveromyces lactis fumarase FUM1 XP_453112.1 83648 D 28985 CDS KLLA0_D00979g 2892752 86703..88388 D 1 NC_006040.1 similar to uniprot|P09232 Saccharomyces cerevisiae YEL060C PRB1 Vacuolar proteinase B (yscB) a serine protease of the subtilisin family involved in protein degradation in the vacuole and required for full protein degradation during sporulation; proteinase B 88388 2892752 KLLA0_D00979g Kluyveromyces lactis proteinase B XP_453114.1 86703 D 28985 CDS KLLA0_D01001g 2893100 88911..89600 D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 89600 2893100 KLLA0_D01001g Kluyveromyces lactis uncharacterized protein XP_453115.1 88911 D 28985 CDS KLLA0_D01023g 2892910 89887..90693 D 1 NC_006040.1 similar to uniprot|Q12339 Saccharomyces cerevisiae YOR004W Protein required for cell viability; rRNA-binding ribosome biosynthesis protein UTP23 90693 2892910 KLLA0_D01023g Kluyveromyces lactis rRNA-binding ribosome biosynthesis protein UTP23 XP_453116.1 89887 D 28985 CDS KLLA0_D01045g 2893511 91110..94007 D 1 NC_006040.1 similar to uniprot|Q8J1G7 Ashbya gossypii ACR010C CIN8 Kinesin-like protein CIN8 and some similarites with YEL061C uniprot|P27895 Saccharomyces cerevisiae YEL061C CIN8 Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation; kinesin motor protein CIN8 94007 2893511 KLLA0_D01045g Kluyveromyces lactis kinesin motor protein CIN8 XP_453117.1 91110 D 28985 CDS KLLA0_D01067g 2892697 complement(94114..96096) D 1 NC_006040.1 similar to uniprot|P39923 Saccharomyces cerevisiae YEL062W NPR2 Regulator of nitrogen permeases transcription is induced in response to proline and urea contains two PEST sequences; nitrogen permease regulating protein NPR2 96096 2892697 KLLA0_D01067g Kluyveromyces lactis nitrogen permease regulating protein NPR2 XP_453118.1 94114 R 28985 CDS KLLA0_D01089g 2892937 complement(97438..100161) D 1 NC_006040.1 similar to uniprot|Q08387 Saccharomyces cerevisiae YOR005C DNL4 DNA ligase required for nonhomologous end-joining (NHEJ) forms stable heterodimer with required cofactor Lif1p catalyzes DNA ligation as part of a complex with Lif1p and Nej1p involved in meiosis not essential for vegetative growth; DNA ligase (ATP) DNL4 100161 2892937 KLLA0_D01089g Kluyveromyces lactis DNA ligase (ATP) DNL4 XP_453119.1 97438 R 28985 CDS KLLA0_D01111g 2892859 complement(100315..101259) D 1 NC_006040.1 similar to uniprot|Q12094 Saccharomyces cerevisiae YOR006C Hypothetical ORF; ribosome biogenesis protein TSR3 101259 2892859 KLLA0_D01111g Kluyveromyces lactis ribosome biogenesis protein TSR3 XP_453120.1 100315 R 28985 CDS KLLA0_D01133g 2893170 101580..104783 D 1 NC_006040.1 some similarities with uniprot|Q04257 Saccharomyces cerevisiae YML002W and some similarities with uniprot|Q04257 Saccharomyces cerevisiae YML003W Hypothetical ORF; uncharacterized protein 104783 2893170 KLLA0_D01133g Kluyveromyces lactis uncharacterized protein XP_453121.1 101580 D 28985 CDS KLLA0_D01155g 2893412 complement(104847..105854) D 1 NC_006040.1 similar to uniprot|Q12118 Saccharomyces cerevisiae YOR007C SGT2 Glutamine-rich cytoplasmic protein of unknown function contains tetratricopeptide (TPR) repeats which often mediate protein-protein interactions conserved in human and C. elegans; uncharacterized protein 105854 2893412 KLLA0_D01155g Kluyveromyces lactis uncharacterized protein XP_453122.1 104847 R 28985 CDS KLLA0_D01221g 2893345 complement(106736..108436) D 1 NC_006040.1 similar to uniprot|Q12001 Saccharomyces cerevisiae YOR002W ALG6 Glucosyltransferase involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation mutations in human ortholog are associated with disease; dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase 108436 2893345 KLLA0_D01221g Kluyveromyces lactis dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase XP_453123.1 106736 R 28985 CDS KLLA0_D01243g 2893016 complement(108848..109783) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 109783 2893016 KLLA0_D01243g Kluyveromyces lactis uncharacterized protein XP_453124.1 108848 R 28985 CDS KLLA0_D01265g 2893025 110784..111407 D 1 NC_006040.1 highly similar to uniprot|P32939 Saccharomyces cerevisiae YML001W YPT7 Gtp-binding protein of the rab family required for homotypic fusion event in vacuole inheritance for endosome-endosome fusion and for fusion of endosomes to vacuoles when expressed from high copy plasmid GTP-binding protein rab family; Rab family GTPase YPT7 111407 2893025 KLLA0_D01265g Kluyveromyces lactis Rab family GTPase YPT7 XP_453125.1 110784 D 28985 CDS KLLA0_D01287g 2893353 112866..113903 D 1 NC_006040.1 similar to uniprot|P20052 Saccharomyces cerevisiae YOL001W PHO80 Cyclin negatively regulates phosphate metabolism Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p deletion of PHO80 leads to aminoglycoside supersensitivity truncated form of PHO80 affects vacuole inheritance; uncharacterized protein 113903 2893353 KLLA0_D01287g Kluyveromyces lactis uncharacterized protein XP_453126.1 112866 D 28985 CDS KLLA0_D01309g 2893367 114713..116947 D 1 NC_006040.1 similar to uniprot|Q12149 Saccharomyces cerevisiae YOR001W RRP6 Exonuclease component of the nuclear exosome contributes to the quality-control system that retains and degrades aberrant mRNAs in the nucleus; exosome nuclease subunit RRP6 116947 2893367 KLLA0_D01309g Kluyveromyces lactis exosome nuclease subunit RRP6 XP_453127.1 114713 D 28985 CDS KLLA0_D01331g 2893007 117469..118395 D 1 NC_006040.1 similar to uniprot|Q12442 Saccharomyces cerevisiae YOL002C IZH2 Membrane protein involved in zinc metabolism member of the four-protein IZH family direct target of the Zap1p transcription factor expression induced by zinc deficiency and fatty acids deletion increases sensitivity to elevated zinc; PAQR-type receptor 118395 2893007 KLLA0_D01331g Kluyveromyces lactis PAQR-type receptor XP_453128.1 117469 D 28985 CDS KLLA0_D01386g 2893355 118965..120434 D 1 NC_006040.1 similar to uniprot|P23796 Saccharomyces cerevisiae YMR283C RIT1 Modifies initiator methionine tRNA to distinguish it from elongator methionine tRNA Initiator methionine tRNA 2'-O-ribosyl phosphate transferase; tRNA A64-2'-O-ribosylphosphate transferase 120434 2893355 KLLA0_D01386g Kluyveromyces lactis tRNA A64-2'-O-ribosylphosphate transferase XP_453130.1 118965 D 28985 CDS KLLA0_D01408g 2893015 120712..122268 D 1 NC_006040.1 weakly similar to uniprot|P22136 Saccharomyces cerevisiae YMR282C AEP2 Mitochondrial protein likely involved in translation of the mitochondrial OLI1 mRNA exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader; uncharacterized protein 122268 2893015 KLLA0_D01408g Kluyveromyces lactis uncharacterized protein XP_453131.1 120712 D 28985 CDS KLLA0_D01430g 2893020 complement(122369..123160) D 1 NC_006040.1 similar to uniprot|Q75DZ3 Ashbya gossypii ABL120W ABL120Wp and weakly similar to YMR281W uniprot|P23797 Saccharomyces cerevisiae YMR281W GPI12 ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly the de- N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate functional homolog of human PIG-Lp; N-acetylglucosaminylphosphatidylinositol deacetylase 123160 2893020 KLLA0_D01430g Kluyveromyces lactis N-acetylglucosaminylphosphatidylinositol deacetylase XP_453132.1 122369 R 28985 CDS KLLA0_D01452g 2893022 124018..128355 D 1 NC_006040.1 similar to uniprot|Q75DZ4 Ashbya gossypii ABL121C ABL121Cp and similar to YMR280C uniprot|P39113 Saccharomyces cerevisiae YMR280C CAT8 Zinc cluster transcriptional activator; DNA-binding transcription factor CAT8 128355 2893022 KLLA0_D01452g Kluyveromyces lactis DNA-binding transcription factor CAT8 XP_453133.1 124018 D 28985 CDS KLLA0_D01485g 2893032 129351..132806 D 1 NC_006040.1 similar to uniprot|Q03735 Saccharomyces cerevisiae YML117W NAB6 Putative RNA-binding protein based on computational analysis of large-scale protein-protein interaction data; uncharacterized protein 132806 2893032 KLLA0_D01485g Kluyveromyces lactis uncharacterized protein XP_453135.1 129351 D 28985 CDS KLLA0_D01507g 2893011 133636..135183 D 1 NC_006040.1 weakly similar to uniprot|Q12303 Saccharomyces cerevisiae YLR121C YPS3 Aspartic protease; uncharacterized protein 135183 2893011 KLLA0_D01507g Kluyveromyces lactis uncharacterized protein XP_453136.1 133636 D 28985 CDS KLLA0_D01529g 2893024 complement(135998..137503) D 1 NC_006040.1 similar to uniprot|P23642 Saccharomyces cerevisiae YML115C VAN1 Mannosyltransferase with a role in protein N-glycosylation; uncharacterized protein 137503 2893024 KLLA0_D01529g Kluyveromyces lactis uncharacterized protein XP_453137.1 135998 R 28985 CDS KLLA0_D01551g 2893019 complement(137965..138960) D 1 NC_006040.1 highly similar to uniprot|Q08985 Saccharomyces cerevisiae YPL273W SAM4 S-adenosylmethionine-homocysteine methyltransferase; S-adenosylmethionine-homocysteine S-methyltransferase SAM4 138960 2893019 KLLA0_D01551g Kluyveromyces lactis S-adenosylmethionine-homocysteine S-methyltransferase SAM4 XP_453138.1 137965 R 28985 CDS KLLA0_D01573g 2893362 complement(139183..141006) D 1 NC_006040.1 similar to uniprot|Q03262 Saccharomyces cerevisiae YMR278W Hypothetical ORF; phosphoribomutase PRM15 141006 2893362 KLLA0_D01573g Kluyveromyces lactis phosphoribomutase PRM15 XP_453139.1 139183 R 28985 CDS KLLA0_D01595g 2893018 complement(141459..143618) D 1 NC_006040.1 similar to uniprot|Q03254 Saccharomyces cerevisiae YMR277W FCP1 Carboxy-terminal domain (CTD) phosphatase; protein serine/threonine phosphatase 143618 2893018 KLLA0_D01595g Kluyveromyces lactis protein serine/threonine phosphatase XP_453140.1 141459 R 28985 CDS KLLA0_D01617g 2893034 complement(143940..145628) D 1 NC_006040.1 weakly similar to uniprot|Q03750 Saccharomyces cerevisiae YML114C TAF8 TFIID subunit (65 kDa) involved in RNA polymerase II transcription initiation; uncharacterized protein 145628 2893034 KLLA0_D01617g Kluyveromyces lactis uncharacterized protein XP_453141.1 143940 R 28985 CDS KLLA0_D01639g 2893029 complement(146344..147489) D 1 NC_006040.1 similar to uniprot|Q03529 Saccharomyces cerevisiae YMR272C SCS7 Required for the hydroxylation of the very long chain fatty acid (VLCFA) located in the endoplasmic reticulum desaturase/hydroxylase enzyme; fatty acid alpha-hydroxylase 147489 2893029 KLLA0_D01639g Kluyveromyces lactis fatty acid alpha-hydroxylase XP_453142.1 146344 R 28985 CDS KLLA0_D01661g 2893351 complement(148193..148531) D 1 NC_006040.1 similar to uniprot|Q03759 Saccharomyces cerevisiae YML108W defines a new subfamily of the split beta-alpha-beta sandwiches.; uncharacterized protein 148531 2893351 KLLA0_D01661g Kluyveromyces lactis uncharacterized protein XP_453143.1 148193 R 28985 CDS KLLA0_D01683g 2893037 complement(148855..151689) D 1 NC_006040.1 some similarities with uniprot|P54786 Saccharomyces cerevisiae YML109W ZDS2 Protein that interacts with silencing proteins at the telomere involved in transcriptional silencing paralog of Zds1p and with YMR273C uniprot|P50111 Saccharomyces cerevisiae YMR273C ZDS1 Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; also has a role in localization of Bcy1p, which is a regulatory subunit of protein kinase A; paralog of Zds2p; uncharacterized protein 151689 2893037 KLLA0_D01683g Kluyveromyces lactis uncharacterized protein XP_453144.1 148855 R 28985 CDS KLLA0_D01705g 2893008 complement(152307..153272) D 1 NC_006040.1 similar to uniprot|Q03530 Saccharomyces cerevisiae YMR274C RCE1 Type II CAAX prenyl protease; CAAX prenyl protease 153272 2893008 KLLA0_D01705g Kluyveromyces lactis CAAX prenyl protease XP_453145.1 152307 R 28985 CDS KLLA0_D01771g 2893349 154445..155359 D 1 NC_006040.1 highly similar to uniprot|P49017 Saccharomyces cerevisiae YML110C COQ5 2-hexaprenyl-6-methoxy-1 4-benzoquinone methyltransferase involved in ubiquinone (Coenzyme Q) biosynthesis located in mitochondria; 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase 155359 2893349 KLLA0_D01771g Kluyveromyces lactis 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase XP_453146.1 154445 D 28985 CDS KLLA0_D01793g 2893366 complement(155616..158402) D 1 NC_006040.1 similar to uniprot|Q03758 Saccharomyces cerevisiae YML111W BUL2 Component of the Rsp5p E3-ubiquitin ligase complex involved in intracellular amino acid permease sorting functions in heat shock element mediated gene expression essential for growth in stress conditions functional homolog of BUL1; uncharacterized protein 158402 2893366 KLLA0_D01793g Kluyveromyces lactis uncharacterized protein XP_453147.1 155616 R 28985 CDS KLLA0_D01815g 2892996 complement(158846..159916) D 1 NC_006040.1 similar to uniprot|P46963 Saccharomyces cerevisiae YML112W CTK3 Gamma subunit of C-terminal domain kinase I (CTDK-I) which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing; uncharacterized protein 159916 2892996 KLLA0_D01815g Kluyveromyces lactis uncharacterized protein XP_453148.1 158846 R 28985 CDS KLLA0_D01837g 2893324 complement(160236..161006) D 1 NC_006040.1 similar to uniprot|P13483 Saccharomyces cerevisiae YML113W DAT1 DNA binding protein that recognizes oligo(dA). oligo(dT) tracts; Arg side chain in its N- terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability; uncharacterized protein 161006 2893324 KLLA0_D01837g Kluyveromyces lactis uncharacterized protein XP_453149.1 160236 R 28985 CDS KLLA0_D01859g 2893342 161628..162743 D 1 NC_006040.1 similar to uniprot|P48510 Saccharomyces cerevisiae YMR276W DSK2 Nuclear-enriched ubiquitin-like polyubiquitin-binding protein required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle involved in proteolysis interacts with the proteasome; ubiquitin domain-containing protein DSK2 162743 2893342 KLLA0_D01859g Kluyveromyces lactis ubiquitin domain-containing protein DSK2 XP_453150.1 161628 D 28985 CDS KLLA0_D01881g 2893028 complement(162870..163847) D 1 NC_006040.1 weakly similar to uniprot|Q03760 Saccharomyces cerevisiae YML107C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; uncharacterized protein 163847 2893028 KLLA0_D01881g Kluyveromyces lactis uncharacterized protein XP_453151.1 162870 R 28985 CDS KLLA0_D01903g 2893005 164524..165204 D 1 NC_006040.1 highly similar to uniprot|P13298 Saccharomyces cerevisiae YML106W URA5 Fifth step in pyrimidine biosynthesis pathway Orotate phosphoribosyltransferase 1; orotate phosphoribosyltransferase URA5 165204 2893005 KLLA0_D01903g Kluyveromyces lactis orotate phosphoribosyltransferase URA5 XP_453152.1 164524 D 28985 CDS KLLA0_D01925g 2892774 complement(165317..166129) D 1 NC_006040.1 similar to uniprot|P29478 Saccharomyces cerevisiae YML105C SEC65 signal recognition particle subunit homologue of mammalian SRP19; RNA-binding signal recognition particle subunit SEC65 166129 2892774 KLLA0_D01925g Kluyveromyces lactis RNA-binding signal recognition particle subunit SEC65 XP_453153.1 165317 R 28985 CDS KLLA0_D01947g 2893333 166415..167653 D 1 NC_006040.1 similar to uniprot|Q756W7 Ashbya gossypii AER288C AER288Cp and weakly similar to YMR270C uniprot|P53437 Saccharomyces cerevisiae YMR270C RRN9 Upstream activation factor subunit; uncharacterized protein 167653 2893333 KLLA0_D01947g Kluyveromyces lactis uncharacterized protein XP_453154.1 166415 D 28985 CDS KLLA0_D01958g 2893009 complement(167629..171015) D 1 NC_006040.1 similar to uniprot|Q01846 Saccharomyces cerevisiae YML104C MDM1 Intermediate filament protein required for nuclear and mitochondrial transmission to daughter buds; uncharacterized protein 171015 2893009 KLLA0_D01958g Kluyveromyces lactis uncharacterized protein XP_453155.1 167629 R 28985 CDS KLLA0_D01980g 2893026 complement(171236..171784) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 171784 2893026 KLLA0_D01980g Kluyveromyces lactis uncharacterized protein XP_453156.1 171236 R 28985 CDS KLLA0_D02002g 2893328 173117..173563 D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 173563 2893328 KLLA0_D02002g Kluyveromyces lactis uncharacterized protein XP_453157.1 173117 D 28985 CDS KLLA0_D02024g 2893033 complement(173877..175547) D 1 NC_006040.1 similar to uniprot|P40357 Saccharomyces cerevisiae YGR009C SEC9 t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; uncharacterized protein 175547 2893033 KLLA0_D02024g Kluyveromyces lactis uncharacterized protein XP_453158.1 173877 R 28985 CDS KLLA0_D02046g 2893010 complement(175907..176644) D 1 NC_006040.1 highly similar to uniprot|Q12522 Saccharomyces cerevisiae YPR016c TIF6 translation initiation factor 6 (eIF6) singleton; translation initiation factor 6 176644 2893010 KLLA0_D02046g Kluyveromyces lactis translation initiation factor 6 XP_453159.1 175907 R 28985 CDS KLLA0_D02068g 2893369 177264..178481 D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 178481 2893369 KLLA0_D02068g Kluyveromyces lactis uncharacterized protein XP_453160.1 177264 D 28985 CDS KLLA0_D02090g 2893365 178880..180688 D 1 NC_006040.1 some similarities with uniprot|Q12495 Saccharomyces cerevisiae YPR018W RLF2 Chromatin Assembly Complex subunit 1: largest (p90) subunit of three-subunit protein complex (yeast CAF-I) involved in DNA-replication-linked nucleosome assembly. Homol. to p150 subunit human Chromatin Assembly Factor-I (CAF-I) p90 subunit of yeast Chromatin Assembly Factor-I (CAF-I); uncharacterized protein 180688 2893365 KLLA0_D02090g Kluyveromyces lactis uncharacterized protein XP_453161.1 178880 D 28985 CDS KLLA0_D02112g 2893027 181482..182015 D 1 NC_006040.1 some similarities with uniprot|P31379 Saccharomyces cerevisiae YAL018C Hypothetical ORF; uncharacterized protein 182015 2893027 KLLA0_D02112g Kluyveromyces lactis uncharacterized protein XP_453162.2 181482 D 28985 CDS KLLA0_D02134g 2892894 complement(182345..184033) D 1 NC_006040.1 highly similar to uniprot|P40970 Saccharomyces cerevisiae YDR062W LCB2 Component of serine palmitoyltransferase responsible along with Lcb1p for the first committed step in sphingolipid synthesis which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine; serine C-palmitoyltransferase LCB2 184033 2892894 KLLA0_D02134g Kluyveromyces lactis serine C-palmitoyltransferase LCB2 XP_453163.1 182345 R 28985 CDS KLLA0_D02156g 2893334 complement(184520..186085) D 1 NC_006040.1 similar to uniprot|Q12298 Saccharomyces cerevisiae YDR061W Mitochondrial protein member of the ATP-binding cassette (ABC) transporter family transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; uncharacterized protein 186085 2893334 KLLA0_D02156g Kluyveromyces lactis uncharacterized protein XP_453164.1 184520 R 28985 CDS KLLA0_D02178g 2893030 186452..187303 D 1 NC_006040.1 similar to uniprot|Q03193 Saccharomyces cerevisiae YDR090C Hypothetical ORF; uncharacterized protein 187303 2893030 KLLA0_D02178g Kluyveromyces lactis uncharacterized protein XP_453165.1 186452 D 28985 CDS KLLA0_D02200g 2893014 complement(187364..187912) D 1 NC_006040.1 similar to uniprot|P36116 Saccharomyces cerevisiae YKR020W (VPS51); uncharacterized protein 187912 2893014 KLLA0_D02200g Kluyveromyces lactis uncharacterized protein XP_453166.1 187364 R 28985 CDS KLLA0_D02222g 2893346 188350..190266 D 1 NC_006040.1 weakly similar to uniprot|P47030 Saccharomyces cerevisiae YJL083W TAX4 and to uniprot|P36115 Saccharomyces cerevisiae YKR019C IRS4; uncharacterized protein 190266 2893346 KLLA0_D02222g Kluyveromyces lactis uncharacterized protein XP_453167.1 188350 D 28985 CDS KLLA0_D02244g 2893339 190557..192734 D 1 NC_006040.1 similar to uniprot|P36114 Saccharomyces cerevisiae YKR018C Hypothetical ORF; uncharacterized protein 192734 2893339 KLLA0_D02244g Kluyveromyces lactis uncharacterized protein XP_453168.1 190557 D 28985 CDS KLLA0_D02266g 2893031 193082..194587 D 1 NC_006040.1 similar to uniprot|P36113 Saccharomyces cerevisiae YKR017C Hypothetical ORF; E3 ubiquitin-protein ligase HEL1 194587 2893031 KLLA0_D02266g Kluyveromyces lactis E3 ubiquitin-protein ligase HEL1 XP_453169.1 193082 D 28985 CDS KLLA0_D02288g 2892798 complement(194724..196286) D 1 NC_006040.1 similar to uniprot|P80428 Saccharomyces cerevisiae YJL081C ARP4 Nuclear actin-related protein involved in chromatin remodeling component of chromatin-remodeling enzyme complexes; uncharacterized protein 196286 2892798 KLLA0_D02288g Kluyveromyces lactis uncharacterized protein XP_453170.1 194724 R 28985 CDS KLLA0_D02310g 2893040 complement(196687..198294) D 1 NC_006040.1 similar to uniprot|P36112 Saccharomyces cerevisiae YKR016W FMP13 The authentic non-tagged protein was localized to the mitochondria; uncharacterized protein 198294 2893040 KLLA0_D02310g Kluyveromyces lactis uncharacterized protein XP_453171.1 196687 R 28985 CDS KLLA0_D02332g 2893035 198735..199220 D 1 NC_006040.1 no similarity; uncharacterized protein 199220 2893035 KLLA0_D02332g Kluyveromyces lactis uncharacterized protein XP_453172.1 198735 D 28985 CDS KLLA0_D02354g 2893327 199795..201057 D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 201057 2893327 KLLA0_D02354g Kluyveromyces lactis uncharacterized protein XP_453173.1 199795 D 28985 CDS KLLA0_D02376g 2893350 201512..202135 D 1 NC_006040.1 similar to uniprot|P36018 Saccharomyces cerevisiae YKR014C YPT52 rab5-like GTPase involved in vacuolar protein sorting and endocytosis probable purine nucleotide- binding protein; Rab family GTPase YPT52 202135 2893350 KLLA0_D02376g Kluyveromyces lactis Rab family GTPase YPT52 XP_453174.1 201512 D 28985 CDS KLLA0_D02398g 2892828 complement(202446..206063) D 1 NC_006040.1 similar to uniprot|P06105 Saccharomyces cerevisiae YJL080C SCP160 May be required during cell division for faithful partitioning of the ER-nuclear envelope membranes involved in control of mitotic chromsome transmission; uncharacterized protein 206063 2892828 KLLA0_D02398g Kluyveromyces lactis uncharacterized protein XP_453175.1 202446 R 28985 CDS KLLA0_D02420g 2893536 complement(206544..207182) D 1 NC_006040.1 some similarities with uniprot|P36110 Saccharomyces cerevisiae YKR013W PRY2 Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins; uncharacterized protein 207182 2893536 KLLA0_D02420g Kluyveromyces lactis uncharacterized protein XP_453176.1 206544 R 28985 CDS KLLA0_D02442g 2893323 complement(207613..208719) D 1 NC_006040.1 some similarities with uniprot|P47032 Saccharomyces cerevisiae YJL079C PRY1 Protein of unknown function, has similarity to Pry2p and Pry3p and to the plant PR-1 class of pathogen related proteins; uncharacterized protein 208719 2893323 KLLA0_D02442g Kluyveromyces lactis uncharacterized protein XP_453177.1 207613 R 28985 CDS KLLA0_D02464g 2893361 complement(209705..210388) D 1 NC_006040.1 similar to uniprot|Q12012 Saccharomyces cerevisiae YOR289W Hypothetical ORF; uncharacterized protein 210388 2893361 KLLA0_D02464g Kluyveromyces lactis uncharacterized protein XP_453178.1 209705 R 28985 CDS KLLA0_D02486g 2892965 210629..211615 D 1 NC_006040.1 similar to uniprot|Q12404 Saccharomyces cerevisiae YOR288C MPD1 Member of the protein disulfide isomerase (PDI) family; protein disulfide isomerase MPD1 211615 2892965 KLLA0_D02486g Kluyveromyces lactis protein disulfide isomerase MPD1 XP_453179.1 210629 D 28985 CDS KLLA0_D02508g 2893457 211891..212358 D 1 NC_006040.1 highly similar to uniprot|Q12487 Saccharomyces cerevisiae YOR150W MRPL23 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein uL13m 212358 2893457 KLLA0_D02508g Kluyveromyces lactis mitochondrial 54S ribosomal protein uL13m XP_453180.1 211891 D 28985 CDS KLLA0_D02530g 2893039 complement(212703..214826) D 1 NC_006040.1 similar to uniprot|Q06440 Saccharomyces cerevisiae YLR429W CRN1 Coronin cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; uncharacterized protein 214826 2893039 KLLA0_D02530g Kluyveromyces lactis uncharacterized protein XP_453181.1 212703 R 28985 CDS KLLA0_D02552g 2893036 complement(215290..217149) D 1 NC_006040.1 similar to uniprot|Q06436 Saccharomyces cerevisiae YLR427W MAG2 DNA-3-methyladenine glycosidase II that catalyzes of the hydrolysis of alkylated DNA; uncharacterized protein 217149 2893036 KLLA0_D02552g Kluyveromyces lactis uncharacterized protein XP_453182.1 215290 R 28985 CDS KLLA0_D02574g 2893347 217940..218449 D 1 NC_006040.1 similar to uniprot|Q04969 Saccharomyces cerevisiae YML055W SPC2 Subunit of signal peptidase complex (Spc1p Spc2p Spc3p Sec11p) which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway homologous to mammalian SPC25; signal peptidase complex subunit SPC2 218449 2893347 KLLA0_D02574g Kluyveromyces lactis signal peptidase complex subunit SPC2 XP_453183.1 217940 D 28985 CDS KLLA0_D02596g 2893017 complement(join(218659..219586,219682..219782)) D 1 NC_006040.1 similar to uniprot|Q06417 Saccharomyces cerevisiae YLR426W Hypothetical ORF; uncharacterized protein 219782 2893017 KLLA0_D02596g Kluyveromyces lactis uncharacterized protein XP_453184.2 218659 R 28985 CDS KLLA0_D02618g 2893021 complement(220267..224253) D 1 NC_006040.1 similar to uniprot|Q06412 Saccharomyces cerevisiae YLR425W TUS1 Guanine nucleotide exchange factor (GEF) that functions to modulate Rhop1 activity as part of the cell integrity signaling pathway multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation potential Cdc28p substrate; Rho family guanine nucleotide exchange factor TUS1 224253 2893021 KLLA0_D02618g Kluyveromyces lactis Rho family guanine nucleotide exchange factor TUS1 XP_453185.1 220267 R 28985 CDS KLLA0_D02640g 2893359 complement(225482..227251) D 1 NC_006040.1 similar to uniprot|P00175 Saccharomyces cerevisiae YML054C CYB2 Cytochrome b2 (L-lactate cytochrome-c oxidoreductase) component of the mitochondrial intermembrane space required for lactate utilization expression is repressed by glucose and anaerobic conditions; L-lactate dehydrogenase (cytochrome) 227251 2893359 KLLA0_D02640g Kluyveromyces lactis L-lactate dehydrogenase (cytochrome) XP_453186.1 225482 R 28985 CDS KLLA0_D02684g 2893012 complement(228564..229166) D 1 NC_006040.1 highly similar to uniprot|P36015 Saccharomyces cerevisiae YKL196C YKT6 v-SNARE (synaptobrevin) essential for endoplasmic reticulum-Golgi transport; palmitoyltransferase YKT6 229166 2893012 KLLA0_D02684g Kluyveromyces lactis palmitoyltransferase YKT6 XP_453187.1 228564 R 28985 CDS KLLA0_D02706g 2893354 229566..230786 D 1 NC_006040.1 some similarities with uniprot|P36046 Saccharomyces cerevisiae YKL195W MIA40 Essential protein of the mitochondrial intermembrane space involved in import and assembly of intermembrane space proteins; uncharacterized protein 230786 2893354 KLLA0_D02706g Kluyveromyces lactis uncharacterized protein XP_453188.1 229566 D 28985 CDS KLLA0_D02728g 2893335 complement(231163..233166) D 1 NC_006040.1 weakly similar to uniprot|Q06411 Saccharomyces cerevisiae YLR424W SPP382 Essential protein present in native splicing complexes identified as a suppressor of prp38-1 a spliceosomal maturation mutation cold sensitive alleles accumulate pre-mRNA; mRNA splicing protein SPP382 233166 2893335 KLLA0_D02728g Kluyveromyces lactis mRNA splicing protein SPP382 XP_453189.1 231163 R 28985 CDS KLLA0_D02750g 2893326 233381..234652 D 1 NC_006040.1 similar to uniprot|Q06410 Saccharomyces cerevisiae YLR423C ATG17 Protein that interacts with and is required for activation of Apg1p protein kinase involved in autophagy but not in the Cvt (cytoplasm to vacuole targeting) pathway; protein kinase regulatory subunit ATG17 234652 2893326 KLLA0_D02750g Kluyveromyces lactis protein kinase regulatory subunit ATG17 XP_453190.1 233381 D 28985 CDS KLLA0_D02772g 2893341 complement(234761..236146) D 1 NC_006040.1 similar to uniprot|P07236 Saccharomyces cerevisiae YKL194C MST1 Mitochondrial threonyl-tRNA synthetase; threonine--tRNA ligase MST1 236146 2893341 KLLA0_D02772g Kluyveromyces lactis threonine--tRNA ligase MST1 XP_453191.1 234761 R 28985 CDS KLLA0_D02794g 2893329 complement(236488..237846) D 1 NC_006040.1 similar to uniprot|P53960 Saccharomyces cerevisiae YNL040W Hypothetical ORF; uncharacterized protein 237846 2893329 KLLA0_D02794g Kluyveromyces lactis uncharacterized protein XP_453192.1 236488 R 28985 CDS KLLA0_D02816g 2893330 complement(238050..239138) D 1 NC_006040.1 similar to uniprot|P36047 Saccharomyces cerevisiae YKL193C SDS22 Regulatory subunit of Glc7p type1 protein phosphatase; type 1 protein phosphatase-activating protein SDS22 239138 2893330 KLLA0_D02816g Kluyveromyces lactis type 1 protein phosphatase-activating protein SDS22 XP_453193.1 238050 R 28985 CDS KLLA0_D02838g 2893357 complement(239515..239880) D 1 NC_006040.1 similar to uniprot|P32463 Saccharomyces cerevisiae YKL192C ACP1 Mitochondrial matrix acyl carrier protein involved in biosynthesis of octanoate which is a precursor to lipoic acid activated by phosphopantetheinylation catalyzed by Ppt2p; acyl carrier protein 239880 2893357 KLLA0_D02838g Kluyveromyces lactis acyl carrier protein XP_453194.1 239515 R 28985 CDS KLLA0_D02860g 2893363 complement(240197..246019) D 1 NC_006040.1 similar to uniprot|Q06409 Saccharomyces cerevisiae YLR422W Hypothetical ORF; uncharacterized protein 246019 2893363 KLLA0_D02860g Kluyveromyces lactis uncharacterized protein XP_453195.1 240197 R 28985 CDS KLLA0_D02882g 2893368 246326..246946 D 1 NC_006040.1 similar to uniprot|O13563 Saccharomyces cerevisiae YLR421C RPN13 Subunit of the 19S regulatory particle of the 26S proteasome lid; proteasome regulatory particle lid subunit RPN13 246946 2893368 KLLA0_D02882g Kluyveromyces lactis proteasome regulatory particle lid subunit RPN13 XP_453196.1 246326 D 28985 CDS KLLA0_D02904g 2893352 247177..247479 D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 247479 2893352 KLLA0_D02904g Kluyveromyces lactis uncharacterized protein XP_453197.1 247177 D 28985 CDS KLLA0_D02926g 2893023 complement(247616..248710) D 1 NC_006040.1 highly similar to uniprot|P20051 Saccharomyces cerevisiae YLR420W URA4 Third step in pyrimidine biosynthesis pathway dihydrooratase; dihydroorotase 248710 2893023 KLLA0_D02926g Kluyveromyces lactis dihydroorotase XP_453198.1 247616 R 28985 CDS KLLA0_D02948g 2893038 249292..251055 D 1 NC_006040.1 similar to uniprot|P32461 Saccharomyces cerevisiae YKL191W DPH2 Protein required along with Dph1p Kti11p Jjj3p and Dph5p for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) may act in a complex with Dph1p and Kti11p; 2-(3-amino-3-carboxypropyl)histidine synthase 251055 2893038 KLLA0_D02948g Kluyveromyces lactis 2-(3-amino-3-carboxypropyl)histidine synthase XP_453199.1 249292 D 28985 CDS KLLA0_D02970g 2893337 252052..253704 D 1 NC_006040.1 similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoin permease ureidosuccinate permease expression is constitutive but sensitive to nitrogen catabolite repression; allantoate permease 253704 2893337 KLLA0_D02970g Kluyveromyces lactis allantoate permease XP_453200.1 252052 D 28985 CDS KLLA0_D02992g 2892802 complement(253918..254445) D 1 NC_006040.1 highly similar to uniprot|P25296 Saccharomyces cerevisiae YKL190W CNB1 Type 2B protein phosphatase regulatory B subunit of calcineurin; calcineurin regulatory subunit B 254445 2892802 KLLA0_D02992g Kluyveromyces lactis calcineurin regulatory subunit B XP_453201.1 253918 R 28985 CDS KLLA0_D03014g 2893344 complement(254897..255658) D 1 NC_006040.1 some similarities with uniprot|P32338 Saccharomyces cerevisiae YGR044C RME1 mediates cell type control of sporulation negatively regulates IME1 and sporulation zinc finger protein negative regulator of meiosis directly repressed by a1-a2 regulator; uncharacterized protein 255658 2893344 KLLA0_D03014g Kluyveromyces lactis uncharacterized protein XP_453202.1 254897 R 28985 CDS KLLA0_D03036g 2893343 complement(255868..256974) D 1 NC_006040.1 similar to uniprot|Q06697 Saccharomyces cerevisiae YLR418C CDC73 Substituent of the Paf1 complex together with RNA polymerase II Paf1p Hpr1p Ctr9 Leo1 Rtf1 and Ccr4p distinct from Srb-containing Pol II complexes required for the expression of certain genes and modification of some histones; uncharacterized protein 256974 2893343 KLLA0_D03036g Kluyveromyces lactis uncharacterized protein XP_453203.1 255868 R 28985 CDS KLLA0_D03058g 2892727 257433..261638 D 1 NC_006040.1 similar to uniprot|Q06698 Saccharomyces cerevisiae YLR419W Hypothetical ORF; uncharacterized protein 261638 2892727 KLLA0_D03058g Kluyveromyces lactis uncharacterized protein XP_453204.1 257433 D 28985 CDS KLLA0_D03146g 2893197 complement(263816..264970) D 1 NC_006040.1 similar to uniprot|P53164 Saccharomyces cerevisiae YGL067W NPY1 NADH diphosphatase (pyrophosphatase) hydrolyzes the pyrophosphate linkage in NADH and related nucleotides localizes to peroxisomes; NAD(+) diphosphatase 264970 2893197 KLLA0_D03146g Kluyveromyces lactis NAD(+) diphosphatase XP_453205.1 263816 R 28985 CDS KLLA0_D03168g 2892961 265761..267278 D 1 NC_006040.1 similar to uniprot|P29295 Saccharomyces cerevisiae YPL204W HRR25 Protein kinase involved in regulating diverse events including vesicular trafficking gene expression DNA repair and chromosome segregation binds the CTD of RNA pol II homolog of mammalian casein kinase 1delta (CK1delta); serine/threonine protein kinase HRR25 267278 2892961 KLLA0_D03168g Kluyveromyces lactis serine/threonine protein kinase HRR25 XP_453206.1 265761 D 28985 CDS KLLA0_D03190g 2893190 267933..269051 D 1 NC_006040.1 highly similar to uniprot|P06245 Saccharomyces cerevisiae YPL203W TPK2 Involved in nutrient control of cell growth and division cAMP-dependent protein kinase catalytic subunit; cAMP-dependent protein kinase catalytic subunit TPK2 269051 2893190 KLLA0_D03190g Kluyveromyces lactis cAMP-dependent protein kinase catalytic subunit TPK2 XP_453207.1 267933 D 28985 CDS KLLA0_D03212g 2892822 complement(269287..269799) D 1 NC_006040.1 similar to uniprot|P53163 Saccharomyces cerevisiae YGL068W MNP1 Protein associated with the mitochondrial nucleoid; mitochondrial 54S ribosomal protein bL12m 269799 2892822 KLLA0_D03212g Kluyveromyces lactis mitochondrial 54S ribosomal protein bL12m XP_453209.1 269287 R 28985 CDS KLLA0_D03234g 2893336 270311..270679 D 1 NC_006040.1 highly similar to uniprot|P27999 Saccharomyces cerevisiae YGL070C RPB9 RNA polymerase II subunit B12.6 contacts DNA mutations affect transcription start site; DNA-directed RNA polymerase II core subunit RPB9 270679 2893336 KLLA0_D03234g Kluyveromyces lactis DNA-directed RNA polymerase II core subunit RPB9 XP_453210.1 270311 D 28985 CDS KLLA0_D03256g 2892710 complement(271036..273507) D 1 NC_006040.1 similar to uniprot|P22149 Saccharomyces cerevisiae YGL071W RCS1 Transcription factor involved in iron utilization and homeostasis binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability; uncharacterized protein 273507 2892710 KLLA0_D03256g Kluyveromyces lactis uncharacterized protein XP_453211.1 271036 R 28985 CDS KLLA0_D03278g 2892991 complement(274580..275734) D 1 NC_006040.1 weakly similar to uniprot|Q08956 Saccharomyces cerevisiae YPL201C; uncharacterized protein 275734 2892991 KLLA0_D03278g Kluyveromyces lactis uncharacterized protein XP_453212.1 274580 R 28985 CDS KLLA0_D03322g 2893291 complement(276591..278624) D 1 NC_006040.1 similar to uniprot|P10961 Saccharomyces cerevisiae YGL073W HSF1 Trimeric heat shock transcription factor activates multiple genes in response to hyperthermia recognizes variable heat shock elements; stress-responsive transcription factor HSF1 278624 2893291 KLLA0_D03322g Kluyveromyces lactis stress-responsive transcription factor HSF1 XP_453214.1 276591 R 28985 CDS KLLA0_D03333g 9487273 279426..279578 D 1 NC_006040.1 no similarity; uncharacterized protein 279578 9487273 KLLA0_D03333g Kluyveromyces lactis uncharacterized protein XP_002999369.1 279426 D 28985 CDS KLLA0_D03344g 2893340 279652..281364 D 1 NC_006040.1 similar to uniprot|P32891 Saccharomyces cerevisiae YDL174C DLD1 D-lactate dehydrogenase oxidizes D-lactate to pyruvate transcription is heme-dependent repressed by glucose and derepressed in ethanol or lactate located in the mitochondrial inner membrane; uncharacterized protein 281364 2893340 KLLA0_D03344g Kluyveromyces lactis uncharacterized protein XP_453215.1 279652 D 28985 CDS KLLA0_D03366g 2893076 281588..282556 D 1 NC_006040.1 weakly similar to uniprot|P53159 Saccharomyces cerevisiae YGL075C MPS2 Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB) required for insertion of the newly duplicated SPB into the nuclear envelope potentially phosphorylated by Cdc28p; uncharacterized protein 282556 2893076 KLLA0_D03366g Kluyveromyces lactis uncharacterized protein XP_453216.1 281588 D 28985 CDS KLLA0_D03388g 2892767 complement(282705..283448) D 1 NC_006040.1 similar to uniprot|Q08954 Saccharomyces cerevisiae YPL199C Hypothetical ORF; uncharacterized protein 283448 2892767 KLLA0_D03388g Kluyveromyces lactis uncharacterized protein XP_453217.1 282705 R 28985 CDS KLLA0_D03410g 2892731 join(284516..284526,285104..285197,285725..286345) D 1 NC_006040.1 highly similar to uniprot|P05737 Saccharomyces cerevisiae YGL076C RPL7A and to uniprot|Q12213 Saccharomyces cerevisiae YPL198W RPL7B Proteins component of the large (60S) ribosomal subunit; 60S ribosomal protein uL30 286345 2892731 KLLA0_D03410g Kluyveromyces lactis 60S ribosomal protein uL30 XP_453218.2 284516 D 28985 CDS KLLA0_D03432g 2892730 287805..292256 D 1 NC_006040.1 similar to uniprot|P32568 Saccharomyces cerevisiae YDR011W SNQ2 ABC transporter; ATP-binding cassette transporter SNQ2 292256 2892730 KLLA0_D03432g Kluyveromyces lactis ATP-binding cassette transporter SNQ2 XP_453219.1 287805 D 28985 CDS KLLA0_D03454g 2892897 293313..295226 D 1 NC_006040.1 similar to uniprot|P05316 YBR021W Saccharomyces cerevisiae FUR4 Uracil permease localized to the plasma membrane; uracil permease 295226 2892897 KLLA0_D03454g Kluyveromyces lactis uracil permease XP_453220.1 293313 D 28985 CDS KLLA0_D03476g 2893356 296287..300969 D 1 NC_006040.1 similar to uniprot|P33302 Saccharomyces cerevisiae YOR153W PDR5 Short-lived membrane ABC (ATP-binding cassette) transporter; uncharacterized protein 300969 2893356 KLLA0_D03476g Kluyveromyces lactis uncharacterized protein XP_453221.1 296287 D 28985 CDS KLLA0_D03498g 2893230 complement(301249..304776) D 1 NC_006040.1 similar to uniprot|P29465 Saccharomyces cerevisiae YBR023C CHS3 Chitin synthase III catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin required for synthesis of the majority of cell wall chitin the chitin ring during bud emergence and spore wall chitosan; chitin synthase CHS3 304776 2893230 KLLA0_D03498g Kluyveromyces lactis chitin synthase CHS3 XP_453222.1 301249 R 28985 CDS KLLA0_D03520g 2892976 305905..307278 D 1 NC_006040.1 highly similar to uniprot|Q96W94 Saccharomyces kluyveri PYD3 Beta-alanine synthase; uncharacterized protein 307278 2892976 KLLA0_D03520g Kluyveromyces lactis uncharacterized protein XP_453223.1 305905 D 28985 CDS KLLA0_D03542g 2892921 complement(307437..310193) D 1 NC_006040.1 similar to uniprot|P14180 Saccharomyces cerevisiae YBR038W CHS2 Chitin synthase II requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin required for the synthesis of chitin in the primary septum during cytokinesis; chitin synthase CHS2 310193 2892921 KLLA0_D03542g Kluyveromyces lactis chitin synthase CHS2 XP_453224.1 307437 R 28985 CDS KLLA0_D03608g 2893246 311190..312371 D 1 NC_006040.1 highly similar to uniprot|P38219 Saccharomyces cerevisiae YBR025C Hypothetical ORF; Obg-like ATPase 312371 2893246 KLLA0_D03608g Kluyveromyces lactis Obg-like ATPase XP_453225.1 311190 D 28985 CDS KLLA0_D03630g 2893043 complement(312661..313599) D 1 NC_006040.1 similar to uniprot|P23833 Saccharomyces cerevisiae YBR037C; uncharacterized protein 313599 2893043 KLLA0_D03630g Kluyveromyces lactis uncharacterized protein XP_453226.1 312661 R 28985 CDS KLLA0_D03652g 2893059 complement(314243..315172) D 1 NC_006040.1 highly similar to uniprot|P20604 Saccharomyces cerevisiae YDL047W SIT4 Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization; type 2A-related serine/threonine-protein phosphatase SIT4 315172 2893059 KLLA0_D03652g Kluyveromyces lactis type 2A-related serine/threonine-protein phosphatase SIT4 XP_453227.1 314243 R 28985 CDS KLLA0_D03674g 2893003 complement(315846..317207) D 1 NC_006040.1 similar to uniprot|Q08231 Saccharomyces cerevisiae YOL072W THP1 Nuclear pore-associated protein forms a complex with Sac3p that is involved in transcription and in mRNA export from the nucleus contains a PAM domain implicated in protein- protein binding; uncharacterized protein 317207 2893003 KLLA0_D03674g Kluyveromyces lactis uncharacterized protein XP_453228.1 315846 R 28985 CDS KLLA0_D03696g 2892803 317854..318312 D 1 NC_006040.1 highly similar to uniprot|P36010 Saccharomyces cerevisiae YKL067W YNK1 Nucleoside diphosphate kinase catalyzes the phosphorylation of nucleoside diphosphates into the corresponding triphosphates for nucleic acid biosynthesis; nucleoside diphosphate kinase 318312 2892803 KLLA0_D03696g Kluyveromyces lactis nucleoside diphosphate kinase XP_453229.1 317854 D 28985 CDS KLLA0_D03718g 2892856 318725..319957 D 1 NC_006040.1 weakly similar to uniprot|P48412 Saccharomyces cerevisiae YGR072W UPF3 Component of the nonsense-mediated mRNA decay (NMD) pathway along with Nam7p and Nmd2p involved in decay of mRNA containing nonsense codons; uncharacterized protein 319957 2892856 KLLA0_D03718g Kluyveromyces lactis uncharacterized protein XP_453230.1 318725 D 28985 CDS KLLA0_D03740g 2892869 320199..320531 D 1 NC_006040.1 no similarity; uncharacterized protein 320531 2892869 KLLA0_D03740g Kluyveromyces lactis uncharacterized protein XP_453231.1 320199 D 28985 CDS KLLA0_D03751g 2892821 complement(320521..321084) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 321084 2892821 KLLA0_D03751g Kluyveromyces lactis uncharacterized protein XP_453232.1 320521 R 28985 CDS KLLA0_D03773g 2892978 321716..322141 D 1 NC_006040.1 similar to uniprot|Q02260 Saccharomyces cerevisiae YGR074W SMD1 Homolog of human core snRNP protein D1 involved in snRNA maturation U6 snRNP protein; mRNA splicing protein SMD1 322141 2892978 KLLA0_D03773g Kluyveromyces lactis mRNA splicing protein SMD1 XP_453233.1 321716 D 28985 CDS KLLA0_D03795g 2892843 complement(322289..322993) D 1 NC_006040.1 similar to uniprot|Q00723 Saccharomyces cerevisiae YGR075C PRP38 Unique component of the U4/U6.U5 tri-snRNP particle dispensable for spliceosome assembly but required for conformational changes which lead to catalytic activation of the spliceosome; U4/U6-U5 snRNP complex subunit PRP38 322993 2892843 KLLA0_D03795g Kluyveromyces lactis U4/U6-U5 snRNP complex subunit PRP38 XP_453234.1 322289 R 28985 CDS KLLA0_D03817g 2893263 complement(323294..323767) D 1 NC_006040.1 similar to uniprot|P23369 Saccharomyces cerevisiae YGR076C MRPL25 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein mL59 323767 2893263 KLLA0_D03817g Kluyveromyces lactis mitochondrial 54S ribosomal protein mL59 XP_453235.1 323294 R 28985 CDS KLLA0_D03839g 2892781 324274..325941 D 1 NC_006040.1 highly similar to uniprot|P04802 Saccharomyces cerevisiae YLL018C DPS1 Cytoplasmic aspartyl-tRNA synthetase homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp) class II aminoacyl tRNA synthetase binding to its own mRNA may confer autoregulation; aspartate--tRNA ligase DPS1 325941 2892781 KLLA0_D03839g Kluyveromyces lactis aspartate--tRNA ligase DPS1 XP_453236.1 324274 D 28985 CDS KLLA0_D03861g 2892864 326381..327973 D 1 NC_006040.1 similar to uniprot|P38738 Saccharomyces cerevisiae YHL029C Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; uncharacterized protein 327973 2892864 KLLA0_D03861g Kluyveromyces lactis uncharacterized protein XP_453237.1 326381 D 28985 CDS KLLA0_D03883g 2892743 328358..329833 D 1 NC_006040.1 weakly similar to uniprot|P32523 Saccharomyces cerevisiae YLL036C PRP19 Splicing factor associated with the spliceosome contains a U-box a motif found in a class of ubiquitin ligases; E3 ubiquitin-protein ligase PRP19 329833 2892743 KLLA0_D03883g Kluyveromyces lactis E3 ubiquitin-protein ligase PRP19 XP_453238.1 328358 D 28985 CDS KLLA0_D03905g 2892713 complement(330128..330634) D 1 NC_006040.1 similar to uniprot|P38143 Saccharomyces cerevisiae YBR244W GPX2 Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; uncharacterized protein 330634 2892713 KLLA0_D03905g Kluyveromyces lactis uncharacterized protein XP_453239.1 330128 R 28985 CDS KLLA0_D03927g 2892763 331864..332472 D 1 NC_006040.1 no similarity; uncharacterized protein 332472 2892763 KLLA0_D03927g Kluyveromyces lactis uncharacterized protein XP_453240.1 331864 D 28985 CDS KLLA0_D03949g 2893555 333566..334243 D 1 NC_006040.1 similar to uniprot|Q07872 Saccharomyces cerevisiae YLL038C ENT4 Protein of unknown function contains an N-terminal epsin- like domain; uncharacterized protein 334243 2893555 KLLA0_D03949g Kluyveromyces lactis uncharacterized protein XP_453241.1 333566 D 28985 CDS KLLA0_D03971g 2892810 334691..334990 D 1 NC_006040.1 similar to uniprot|Q3E731 Saccharomyces cerevisiae YLL018C-A COX19 Cytochrome c oxidase assembly protein; uncharacterized protein 334990 2892810 KLLA0_D03971g Kluyveromyces lactis uncharacterized protein XP_453242.1 334691 D 28985 CDS KLLA0_D04037g 2892931 336499..337833 D 1 NC_006040.1 highly similar to uniprot|P06106 Saccharomyces cerevisiae YLR303W MET17 O-acetyl homoserine-O-acetyl serine sulfhydrylase required for sulfur amino acid synthesis; bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17 337833 2892931 KLLA0_D04037g Kluyveromyces lactis bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17 XP_453243.1 336499 D 28985 CDS KLLA0_D04059g 2892750 complement(338422..343128) D 1 NC_006040.1 similar to uniprot|P14772 Saccharomyces cerevisiae YLL015W BPT1 ABC type transmembrane transporter of MRP/CFTR family found in vacuolar membrane involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates along with Ycf1p; ATP-binding cassette bilirubin transporter BPT1 343128 2892750 KLLA0_D04059g Kluyveromyces lactis ATP-binding cassette bilirubin transporter BPT1 XP_453244.1 338422 R 28985 CDS KLLA0_D04092g 2893154 complement(344666..348124) D 1 NC_006040.1 similar to uniprot|P38995 Saccharomyces cerevisiae YDR270W CCC2 copper-transporting P-type ATPase with similarity to human Menkes and Wilsons genes; Cu(2+)-transporting ATPase; uncharacterized protein 348124 2893154 KLLA0_D04092g Kluyveromyces lactis uncharacterized protein XP_453246.1 344666 R 28985 CDS KLLA0_D04114g 2893126 complement(348791..350278) D 1 NC_006040.1 similar to uniprot|P32457 Saccharomyces cerevisiae YLR314C CDC3 Component of the septin ring of the mother-bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM; septin CDC3 350278 2893126 KLLA0_D04114g Kluyveromyces lactis septin CDC3 XP_453247.1 348791 R 28985 CDS KLLA0_D04136g 2893462 350976..352124 D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 352124 2893462 KLLA0_D04136g Kluyveromyces lactis uncharacterized protein XP_453248.1 350976 D 28985 CDS KLLA0_D04158g 2893398 complement(353145..354698) D 1 NC_006040.1 some similarities with uniprot|Q03654 Saccharomyces cerevisiae YMR213W CEF1 Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association; uncharacterized protein 354698 2893398 KLLA0_D04158g Kluyveromyces lactis uncharacterized protein XP_453249.1 353145 R 28985 CDS KLLA0_D04181g 9487522 357299..357532 D 1 NC_006040.1 no similarity; uncharacterized protein 357532 9487522 KLLA0_D04181g Kluyveromyces lactis uncharacterized protein XP_002999370.1 357299 D 28985 CDS KLLA0_D04202g 2893543 362270..363061 D 1 NC_006040.1 weakly similar to uniprot|Q12164 Saccharomyces cerevisiae YLL023C Hypothetical ORF; nucleoporin POM33 363061 2893543 KLLA0_D04202g Kluyveromyces lactis nucleoporin POM33 XP_453251.1 362270 D 28985 CDS KLLA0_D04224g 2893121 363732..365654 D 1 NC_006040.1 highly similar to uniprot|P10592 Saccharomyces cerevisiae YLL024C SSA2 member of 70 kDa heat shock protein family; Hsp70 family chaperone SSA2 365654 2893121 KLLA0_D04224g Kluyveromyces lactis Hsp70 family chaperone SSA2 XP_453252.1 363732 D 28985 CDS KLLA0_D04334g 2893575 368361..368579 D 1 NC_006040.1 similar to gnl|GLV|CAGL0J01699g Candida glabrata CAGL0J01699g; uncharacterized protein 368579 2893575 KLLA0_D04334g Kluyveromyces lactis uncharacterized protein XP_453255.1 368361 D 28985 CDS KLLA0_D04356g 2893389 complement(369403..371277) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 371277 2893389 KLLA0_D04356g Kluyveromyces lactis uncharacterized protein XP_453256.1 369403 R 28985 CDS KLLA0_D04378g 2893544 complement(372640..373542) D 1 NC_006040.1 similar to uniprot|P53212 Saccharomyces cerevisiae YGR021W Hypothetical ORF; uncharacterized protein 373542 2893544 KLLA0_D04378g Kluyveromyces lactis uncharacterized protein XP_453257.1 372640 R 28985 CDS KLLA0_D04400g 2893509 374127..374483 D 1 NC_006040.1 highly similar to uniprot|P39111 Saccharomyces cerevisiae YGR020C VMA7 Vacuolar H ATPase subunit F of the catalytic (V1) sector; H(+)-transporting V1 sector ATPase subunit F 374483 2893509 KLLA0_D04400g Kluyveromyces lactis H(+)-transporting V1 sector ATPase subunit F XP_453258.1 374127 D 28985 CDS KLLA0_D04422g 2893348 complement(374631..376199) D 1 NC_006040.1 some similarities with uniprot|Q12114 Saccharomyces cerevisiae YLR330W CHS5 Protein of unknown function involved in chitin biosynthesis by regulating Chs3p localization also involved in cell fusion during mating; uncharacterized protein 376199 2893348 KLLA0_D04422g Kluyveromyces lactis uncharacterized protein XP_453259.1 374631 R 28985 CDS KLLA0_D04444g 2892714 377424..379379 D 1 NC_006040.1 highly similar to uniprot|Q00711 Saccharomyces cerevisiae YKL148C SDH1 Flavoprotein subunit of succinate dehydrogenase (Sdh1p Sdh2p Sdh3p Sdh4p) which couples the oxidation of succinate to the transfer of electrons to ubiquinone; succinate dehydrogenase flavoprotein subunit SDH1 379379 2892714 KLLA0_D04444g Kluyveromyces lactis succinate dehydrogenase flavoprotein subunit SDH1 XP_453260.1 377424 D 28985 CDS KLLA0_D04466g 2893325 380305..381462 D 1 NC_006040.1 similar to uniprot|P24309 Saccharomyces cerevisiae YKL149C DBR1 RNA lariat debranching enzyme involved in intron turnover required for efficient Ty1 transposition; RNA lariat debranching enzyme 381462 2893325 KLLA0_D04466g Kluyveromyces lactis RNA lariat debranching enzyme XP_453261.1 380305 D 28985 CDS KLLA0_D04488g 2893331 complement(381861..382751) D 1 NC_006040.1 similar to uniprot|P36060 Saccharomyces cerevisiae YKL150W MCR1 Mitochondrial NADH-cytochrome b5 reductase involved in ergosterol biosynthesis; cytochrome-b5 reductase 382751 2893331 KLLA0_D04488g Kluyveromyces lactis cytochrome-b5 reductase XP_453262.1 381861 R 28985 CDS KLLA0_D04510g 2893066 383229..384221 D 1 NC_006040.1 similar to uniprot|P36059 Saccharomyces cerevisiae YKL151C Hypothetical ORF; NADHX dehydratase 384221 2893066 KLLA0_D04510g Kluyveromyces lactis NADHX dehydratase XP_453263.1 383229 D 28985 CDS KLLA0_D04532g 2893364 complement(384354..385445) D 1 NC_006040.1 similar to uniprot|P32910 Saccharomyces cerevisiae YNR003C RPC34 RNA polymerase III subunit C34 interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex; DNA-directed RNA polymerase III subunit C34 385445 2893364 KLLA0_D04532g Kluyveromyces lactis DNA-directed RNA polymerase III subunit C34 XP_453264.1 384354 R 28985 CDS KLLA0_D04554g 2892892 complement(385733..388801) D 1 NC_006040.1 similar to uniprot|P25371 Saccharomyces cerevisiae YCR011C ADP1 Shows homology to ATP-dependent permeases Active transport ATPase; uncharacterized protein 388801 2892892 KLLA0_D04554g Kluyveromyces lactis uncharacterized protein XP_453265.1 385733 R 28985 CDS KLLA0_D04576g 2893498 complement(389302..390309) D 1 NC_006040.1 similar to uniprot|P43599 Saccharomyces cerevisiae YFR018C Hypothetical ORF; uncharacterized protein 390309 2893498 KLLA0_D04576g Kluyveromyces lactis uncharacterized protein XP_453266.1 389302 R 28985 CDS KLLA0_D04598g 2893499 390602..396766 D 1 NC_006040.1 similar to uniprot|P34756 Saccharomyces cerevisiae YFR019W FAB1 1-phosphatidylinositol-3-phosphate 5-kinase vacuolar membrane kinase that generates phosphatidylinositol (3 5)P2 which is involved in vacuolar sorting and homeostasis; 1-phosphatidylinositol-3-phosphate 5-kinase 396766 2893499 KLLA0_D04598g Kluyveromyces lactis 1-phosphatidylinositol-3-phosphate 5-kinase XP_453267.1 390602 D 28985 CDS KLLA0_D04664g 2892881 397818..399320 D 1 NC_006040.1 similar to uniprot|P43601 Saccharomyces cerevisiae YFR021W ATG18 Phosphatidylinositol 3 5-bisphosphate-binding protein of the vacuolar membrane predicted to fold as a seven-bladed beta-propeller required for recycling of Atg9p through the pre-autophagosomal structure; phosphoinositide binding protein ATG18 399320 2892881 KLLA0_D04664g Kluyveromyces lactis phosphoinositide binding protein ATG18 XP_453268.1 397818 D 28985 CDS KLLA0_D04686g 2893318 complement(399588..399950) D 1 NC_006040.1 no similarity; uncharacterized protein 399950 2893318 KLLA0_D04686g Kluyveromyces lactis uncharacterized protein XP_453269.1 399588 R 28985 CDS KLLA0_D04708g 2893338 400541..402895 D 1 NC_006040.1 similar to uniprot|Q759V0 Ashbya gossypii ADR172C ADR172Cp and weakly similar to YOR018W uniprot|Q02805 Saccharomyces cerevisiae YOR018W ROD1 Membrane protein overexpression confers resistance to the GST substrate o-dinitrobenzene as well as to zinc and calcium contains a PY-motif which is required for Rod1p interaction with Rsp5p a hect-type ubiquitin ligase; uncharacterized protein 402895 2893338 KLLA0_D04708g Kluyveromyces lactis uncharacterized protein XP_453270.1 400541 D 28985 CDS KLLA0_D04752g 2893287 join(404281..404340,404457..405737) D 1 NC_006040.1 similar to uniprot|P25604 Saccharomyces cerevisiae YCL008C STP22 Component of the ESCRT-I complex which is involved in ubiquitin-dependent sorting of proteins into the endosome homologous to the mouse and human Tsg101 tumor susceptibility gene mutants exhibit a Class E Vps phenotype; ubiquitin-binding ESCRT-I subunit protein STP22 405737 2893287 KLLA0_D04752g Kluyveromyces lactis ubiquitin-binding ESCRT-I subunit protein STP22 XP_453271.2 404281 D 28985 CDS KLLA0_D04774g 2893293 406024..408846 D 1 NC_006040.1 some similarities with uniprot|P25386 Saccharomyces cerevisiae YDL058W USO1 involved intracellular protein transport coiled-coil protein necessary for protein transport from ER to Golgi Integrin analogue gene; uncharacterized protein 408846 2893293 KLLA0_D04774g Kluyveromyces lactis uncharacterized protein XP_453272.1 406024 D 28985 CDS KLLA0_D04796g 2893295 409305..410729 D 1 NC_006040.1 uniprot|O13473 Kluyveromyces lactis CBF5 Centromere/microtubule-binding protein CBF5; uncharacterized protein 410729 2893295 KLLA0_D04796g Kluyveromyces lactis uncharacterized protein XP_453273.1 409305 D 28985 CDS KLLA0_D04818g 2893163 complement(411615..412679) D 1 NC_006040.1 similar to gnl|GLV|CAGL0H03707g Candida glabrata CAGL0H03707g and some similarites with YNL007C uniprot|P25294 Saccharomyces cerevisiae YNL007C SIS1 HSP40 family chaperone sit4 suppressor dnaJ homolog; type II HSP40 co-chaperone SIS1 412679 2893163 KLLA0_D04818g Kluyveromyces lactis type II HSP40 co-chaperone SIS1 XP_453274.1 411615 R 28985 CDS KLLA0_D04840g 2893311 413362..414273 D 1 NC_006040.1 highly similar to uniprot|P41318 Saccharomyces cerevisiae YNL006W LST8 Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface component of the TOR signaling pathway associates with both Tor1p and Tor2p contains a WD-repeat; TOR complex subunit LST8 414273 2893311 KLLA0_D04840g Kluyveromyces lactis TOR complex subunit LST8 XP_453275.1 413362 D 28985 CDS KLLA0_D04862g 2893149 complement(414872..417331) D 1 NC_006040.1 some similarities with uniprot|P48743 Saccharomyces cerevisiae YLR176C; uncharacterized protein 417331 2893149 KLLA0_D04862g Kluyveromyces lactis uncharacterized protein XP_453276.1 414872 R 28985 CDS KLLA0_D04884g 2892740 419435..420391 D 1 NC_006040.1 similar to uniprot|P40693 Saccharomyces cerevisiae YNL002C; uncharacterized protein 420391 2892740 KLLA0_D04884g Kluyveromyces lactis uncharacterized protein XP_453277.1 419435 D 28985 CDS KLLA0_D04906g 2892896 420903..421991 D 1 NC_006040.1 highly similar to uniprot|P04173 Saccharomyces cerevisiae YCL018W LEU2 Beta-isopropylmalate dehydrogenase catalyzes the third step in the leucine biosynthesis pathway; 3-isopropylmalate dehydrogenase 421991 2892896 KLLA0_D04906g Kluyveromyces lactis 3-isopropylmalate dehydrogenase XP_453278.1 420903 D 28985 CDS KLLA0_D04928g 2892720 complement(422549..424042) D 1 NC_006040.1 highly similar to uniprot|P25374 Saccharomyces cerevisiae YCL017C NFS1 Cysteine desulfurase involved in iron-sulfur cluster (Fe/S)biogenesis required for the post-transcriptional thio-modification of mitochondrial and cytoplasmic tRNAs essential protein located predominantly in mitochondria; cysteine desulfurase 424042 2892720 KLLA0_D04928g Kluyveromyces lactis cysteine desulfurase XP_453279.1 422549 R 28985 CDS KLLA0_D04950g 2893435 424550..425374 D 1 NC_006040.1 similar to uniprot|P38921 Saccharomyces cerevisiae YNL003C PET8 S-adenosylmethionine transporter of the mitochondrial inner membrane member of the mitochondrial carrier family required for biotin biosynthesis and respiratory growth; uncharacterized protein 425374 2893435 KLLA0_D04950g Kluyveromyces lactis uncharacterized protein XP_453280.1 424550 D 28985 CDS KLLA0_D04972g 2892771 complement(425543..426661) D 1 NC_006040.1 similar to uniprot|P25559 Saccharomyces cerevisiae YCL016C DCC1 Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C required for sister chromatid cohesion; uncharacterized protein 426661 2892771 KLLA0_D04972g Kluyveromyces lactis uncharacterized protein XP_453281.1 425543 R 28985 CDS KLLA0_D04994g 2892711 427195..431481 D 1 NC_006040.1 similar to uniprot|Q9HF61 Ashbya gossypii AAL016C BUD3 Bud site selection protein BUD3 and weakly similar to YCL014W uniprot|P25558 Saccharomyces cerevisiae YCL014W BUD3 Protein involved in bud-site selection and required for axial budding pattern localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding; uncharacterized protein 431481 2892711 KLLA0_D04994g Kluyveromyces lactis uncharacterized protein XP_453282.1 427195 D 28985 CDS KLLA0_D05016g 2892889 complement(join(431592..432911,433342..433353)) D 1 NC_006040.1 similar to uniprot|P38922 Saccharomyces cerevisiae YNL004W; uncharacterized protein 433353 2892889 KLLA0_D05016g Kluyveromyces lactis uncharacterized protein XP_453283.2 431592 R 28985 CDS KLLA0_D05038g 2892726 433653..435674 D 1 NC_006040.1 similar to uniprot|Q754A1 Ashbya gossypii AFR171W AFR171Wp and weakly similar to YDR034C uniprot|P40971 Saccharomyces cerevisiae YDR034C LYS14 Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway requires 2-aminoadipate semialdehyde as co-inducer; uncharacterized protein 435674 2892726 KLLA0_D05038g Kluyveromyces lactis uncharacterized protein XP_453284.1 433653 D 28985 CDS KLLA0_D05060g 2892751 436335..437906 D 1 NC_006040.1 similar to uniprot|P53099 Saccharomyces cerevisiae YGL186C TPN1 Pyridoxine transporter; uncharacterized protein 437906 2892751 KLLA0_D05060g Kluyveromyces lactis uncharacterized protein XP_453285.1 436335 D 28985 CDS KLLA0_D05082g 2893409 438653..439117 D 1 NC_006040.1 highly similar to uniprot|P04037 Saccharomyces cerevisiae YGL187C COX4 Subunit IV of cytochrome c oxidase which is the terminal member of the mitochondrial inner membrane electron transport chain N-terminal 25 residues of precursor are cleaved during mitochondrial import; cytochrome c oxidase subunit IV 439117 2893409 KLLA0_D05082g Kluyveromyces lactis cytochrome c oxidase subunit IV XP_453286.1 438653 D 28985 CDS KLLA0_D05115g 2892799 440882..441241 D 1 NC_006040.1 highly similar to uniprot|P39938 Saccharomyces cerevisiae YGL189C; 40S ribosomal protein eS26 441241 2892799 KLLA0_D05115g Kluyveromyces lactis 40S ribosomal protein eS26 XP_453288.1 440882 D 28985 CDS KLLA0_D05137g 2892842 441827..443614 D 1 NC_006040.1 highly similar to uniprot|P15624 Saccharomyces cerevisiae YLR060W FRS1 Beta subunit of cytoplasmic phenylalanyl- tRNA synthetase, forms a tetramer with Frs2p to generate the active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence,but substrate binding is similar and similar to gnl|GLV|YALI0E22979g; phenylalanine--tRNA ligase subunit beta 443614 2892842 KLLA0_D05137g Kluyveromyces lactis phenylalanine--tRNA ligase subunit beta XP_453289.1 441827 D 28985 CDS KLLA0_D05159g 2893529 complement(443727..446465) D 1 NC_006040.1 similar to uniprot|Q75BQ1 Ashbya gossypii ACR220C ACR220Cp and weakly similar to YFL034W uniprot|P43564 Saccharomyces cerevisiae YFL034W Possible integral membrane protein that interacts with Rpp0p which is a component of the ribosomal stalk; uncharacterized protein 446465 2893529 KLLA0_D05159g Kluyveromyces lactis uncharacterized protein XP_453290.1 443727 R 28985 CDS KLLA0_D05181g 2892759 join(446903..446914,447399..447755) D 1 NC_006040.1 similar to uniprot|P05749 Saccharomyces cerevisiae YLR061W RPL22A Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Bp and to rat L22 ribosomal protein; 60S ribosomal protein eL22 447755 2892759 KLLA0_D05181g Kluyveromyces lactis 60S ribosomal protein eL22 XP_453291.1 446903 D 28985 CDS KLLA0_D05203g 2892825 448206..449249 D 1 NC_006040.1 similar to uniprot|Q12291 Saccharomyces cerevisiae YLR063W Hypothetical ORF; 25S rRNA (uracil2843-N3)-methyltransferase 449249 2892825 KLLA0_D05203g Kluyveromyces lactis 25S rRNA (uracil2843-N3)-methyltransferase XP_453292.1 448206 D 28985 CDS KLLA0_D05225g 2893526 join(449550..449572,449678..450470) D 1 NC_006040.1 similar to uniprot|P43563 Saccharomyces cerevisiae YFL034C-B MOB2 Component of the RAM signaling network localizes and activates the Ace2p in the daughter cell nucleus to direct daughter cell-specific transcription of several genes involved in cell separation Mob1p-like protein; uncharacterized protein 450470 2893526 KLLA0_D05225g Kluyveromyces lactis uncharacterized protein XP_453293.1 449550 D 28985 CDS KLLA0_D05247g 2893050 complement(450769..454560) D 1 NC_006040.1 similar to uniprot|P13433 Saccharomyces cerevisiae YFL036W; DNA-directed RNA polymerase 454560 2893050 KLLA0_D05247g Kluyveromyces lactis DNA-directed RNA polymerase XP_453294.1 450769 R 28985 CDS KLLA0_D05269g 2892769 complement(455261..456610) D 1 NC_006040.1 highly similar to uniprot|P02557 Saccharomyces cerevisiae YFL037W TUB2 Beta-tubulin associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer which polymerizes to form microtubules; beta-tubulin 456610 2892769 KLLA0_D05269g Kluyveromyces lactis beta-tubulin XP_453295.1 455261 R 28985 CDS KLLA0_D05291g 2892819 457872..458738 D 1 NC_006040.1 similar to uniprot|Q12144 Saccharomyces cerevisiae YLR064W Hypothetical ORF; uncharacterized protein 458738 2892819 KLLA0_D05291g Kluyveromyces lactis uncharacterized protein XP_453296.1 457872 D 28985 CDS KLLA0_D05313g 2892728 459496..460110 D 1 NC_006040.1 highly similar to uniprot|P01123 Saccharomyces cerevisiae YFL038C YPT1 Ras-like small GTPase involved in the ER-to-Golgi step of the secretory pathway complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); Rab family GTPase YPT1 460110 2892728 KLLA0_D05313g Kluyveromyces lactis Rab family GTPase YPT1 XP_453297.1 459496 D 28985 CDS KLLA0_D05335g 2893101 complement(460426..460971) D 1 NC_006040.1 similar to uniprot|Q6Q5C1 Saccharomyces cerevisiae YLR065C Hypothetical ORF; uncharacterized protein 460971 2893101 KLLA0_D05335g Kluyveromyces lactis uncharacterized protein XP_453298.1 460426 R 28985 CDS KLLA0_D05357g 2893427 join(461726..461735,462516..463633) D 1 NC_006040.1 highly similar to uniprot|P60010 Saccharomyces cerevisiae YFL039C ACT1 Actin structural protein involved in cell polarization endocytosis and other cytoskeletal functions; actin 463633 2893427 KLLA0_D05357g Kluyveromyces lactis actin XP_453299.1 461726 D 28985 CDS KLLA0_D05379g 2892748 complement(464200..465690) D 1 NC_006040.1 weakly similar to uniprot|P43562 Saccharomyces cerevisiae YFL040W; uncharacterized protein 465690 2892748 KLLA0_D05379g Kluyveromyces lactis uncharacterized protein XP_453300.1 464200 R 28985 CDS KLLA0_D05401g 2892699 466109..466678 D 1 NC_006040.1 similar to uniprot|Q12133 Saccharomyces cerevisiae YLR066W SPC3 Subunit of signal peptidase complex (Spc1p Spc2p Spc3p Sec11p) which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway homologous to mammalian SPC22/23; signal peptidase complex subunit SPC3 466678 2892699 KLLA0_D05401g Kluyveromyces lactis signal peptidase complex subunit SPC3 XP_453301.1 466109 D 28985 CDS KLLA0_D05423g 2892995 complement(466943..469792) D 1 NC_006040.1 similar to uniprot|P32522 Saccharomyces cerevisiae YLR067C PET309 Specific translational activator for the COX1 mRNA also influences stability of intron-containing COX1 primary transcripts located in the mitochondrial inner membrane; uncharacterized protein 469792 2892995 KLLA0_D05423g Kluyveromyces lactis uncharacterized protein XP_453302.1 466943 R 28985 CDS KLLA0_D05445g 2892858 470419..470853 D 1 NC_006040.1 similar to uniprot|Q12247 Saccharomyces cerevisiae YLR068W FYV7 Protein of unknown function required for survival upon exposure to K1 killer toxin involved in processing the 35S rRNA primary transcript to generate the 20S and 27SA2 pre- rRNA transcripts; uncharacterized protein 470853 2892858 KLLA0_D05445g Kluyveromyces lactis uncharacterized protein XP_453303.1 470419 D 28985 CDS KLLA0_D05467g 2893410 complement(471053..473320) D 1 NC_006040.1 highly similar to uniprot|P25039 Saccharomyces cerevisiae YLR069C MEF1 mitochondrial elongation factor G-like protein; uncharacterized protein 473320 2893410 KLLA0_D05467g Kluyveromyces lactis uncharacterized protein XP_453304.1 471053 R 28985 CDS KLLA0_D05489g 2892756 complement(473992..475845) D 1 NC_006040.1 similar to uniprot|P43561 Saccharomyces cerevisiae YFL041W; ferroxidase FET5 475845 2892756 KLLA0_D05489g Kluyveromyces lactis ferroxidase FET5 XP_453305.1 473992 R 28985 CDS KLLA0_D05511g 2893070 complement(476363..477427) D 1 NC_006040.1 similar to uniprot|P35497 Saccharomyces cerevisiae YJR159W SOR1 Sorbitol dehydrogenase expression is induced in the presence of sorbitol; D-xylulose reductase XYL2 477427 2893070 KLLA0_D05511g Kluyveromyces lactis D-xylulose reductase XYL2 XP_453306.1 476363 R 28985 CDS KLLA0_D05533g 2893173 complement(478454..481450) D 1 NC_006040.1 similar to uniprot|P19263 Saccharomyces cerevisiae YLR071C RGR1 Component of RNA polymerase II holoenzyme/mediator complex affects chromatin structure and transcriptional regulation of diverse genes required for glucose repression HO repression RME1 repression and sporulation; uncharacterized protein 481450 2893173 KLLA0_D05533g Kluyveromyces lactis uncharacterized protein XP_453307.1 478454 R 28985 CDS KLLA0_D05555g 2893176 482279..484453 D 1 NC_006040.1 weakly similar to uniprot|P43560 Saccharomyces cerevisiae YFL042C Due to a sequence change (deletion of G at 46151) YFL043C is now part of YFL042C; uncharacterized protein 484453 2893176 KLLA0_D05555g Kluyveromyces lactis uncharacterized protein XP_453308.1 482279 D 28985 CDS KLLA0_D05577g 2893240 complement(484697..485266) D 1 NC_006040.1 similar to uniprot|Q08003 Saccharomyces cerevisiae YLR073C Hypothetical ORF; uncharacterized protein 485266 2893240 KLLA0_D05577g Kluyveromyces lactis uncharacterized protein XP_453309.1 484697 R 28985 CDS KLLA0_D05599g 2893607 485753..486712 D 1 NC_006040.1 similar to uniprot|P43558 Saccharomyces cerevisiae YFL044C YOD1 Yeast OTU Deubiquitinating enzyme 1; ubiquitin-specific protease OTU1 486712 2893607 KLLA0_D05599g Kluyveromyces lactis ubiquitin-specific protease OTU1 XP_453310.1 485753 D 28985 CDS KLLA0_D05621g 2893451 complement(486879..487382) D 1 NC_006040.1 similar to uniprot|Q08004 Saccharomyces cerevisiae YLR074C BUD20 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; uncharacterized protein 487382 2893451 KLLA0_D05621g Kluyveromyces lactis uncharacterized protein XP_453311.1 486879 R 28985 CDS KLLA0_D05643g 2893562 488021..488683 D 1 NC_006040.1 highly similar to uniprot|P41805 Saccharomyces cerevisiae YLR075W; 60S ribosomal protein uL16 488683 2893562 KLLA0_D05643g Kluyveromyces lactis 60S ribosomal protein uL16 XP_453312.1 488021 D 28985 CDS KLLA0_D05709g 2892812 492707..493471 D 1 NC_006040.1 highly similar to uniprot|P07283 Saccharomyces cerevisiae YFL045C SEC53 involved in synthesis of GDP-mannose and dolichol-phosphate-mannose required for protein assembly in endoplasmic reticulum phosphomannomutase; phosphomannomutase SEC53 493471 2892812 KLLA0_D05709g Kluyveromyces lactis phosphomannomutase SEC53 XP_453316.1 492707 D 28985 CDS KLLA0_D05731g 2892900 complement(493687..494325) D 1 NC_006040.1 highly similar to uniprot|P43557 Saccharomyces cerevisiae YFL046W FMP32 The authentic non-tagged protein was localized to the mitochondria; uncharacterized protein 494325 2892900 KLLA0_D05731g Kluyveromyces lactis uncharacterized protein XP_453317.1 493687 R 28985 CDS KLLA0_D05753g 2892912 494751..496592 D 1 NC_006040.1 similar to uniprot|Q7LI62 Saccharomyces cerevisiae YLR077W FMP25 The authentic non-tagged protein was localized to the mitochondria; uncharacterized protein 496592 2892912 KLLA0_D05753g Kluyveromyces lactis uncharacterized protein XP_453318.1 494751 D 28985 CDS KLLA0_D05775g 2893055 complement(join(496779..497522,497638..497640)) D 1 NC_006040.1 similar to uniprot|P25385 Saccharomyces cerevisiae YLR078C BOS1 v-SNARE (vesicle specific SNAP receptor) localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi; uncharacterized protein 497640 2893055 KLLA0_D05775g Kluyveromyces lactis uncharacterized protein XP_453319.1 496779 R 28985 CDS KLLA0_D05797g 2893579 498347..499150 D 1 NC_006040.1 similar to uniprot|Q75CY2 Ashbya gossypii ABR240W ABR240Wp and weakly similar to YLR079W uniprot|P38634 Saccharomyces cerevisiae YLR079W SIC1 P40 inhibitor of Cdc28p-Clb5p protein kinase complex; cyclin-dependent protein serine/threonine kinase inhibiting protein SIC1 499150 2893579 KLLA0_D05797g Kluyveromyces lactis cyclin-dependent protein serine/threonine kinase inhibiting protein SIC1 XP_453320.1 498347 D 28985 CDS KLLA0_D05819g 2893131 complement(499409..501472) D 1 NC_006040.1 similar to uniprot|P43556 Saccharomyces cerevisiae YFL047W RGD2 GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; GTPase-activating protein RGD2 501472 2893131 KLLA0_D05819g Kluyveromyces lactis GTPase-activating protein RGD2 XP_453321.1 499409 R 28985 CDS KLLA0_D05841g 2893169 501740..502138 D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 502138 2893169 KLLA0_D05841g Kluyveromyces lactis uncharacterized protein XP_453322.1 501740 D 28985 CDS KLLA0_D05863g 2893224 502506..503819 D 1 NC_006040.1 similar to uniprot|P43555 Saccharomyces cerevisiae YFL048C EMP47 Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles which function in ER to Golgi transport; uncharacterized protein 503819 2893224 KLLA0_D05863g Kluyveromyces lactis uncharacterized protein XP_453323.1 502506 D 28985 CDS KLLA0_D05885g 2893590 complement(503910..505442) D 1 NC_006040.1 similar to uniprot|Q75CX8 Ashbya gossypii ABR244C ABR244Cp and weakly similar to YFL049W uniprot|P43554 Saccharomyces cerevisiae YFL049W Hypothetical ORF; uncharacterized protein 505442 2893590 KLLA0_D05885g Kluyveromyces lactis uncharacterized protein XP_453324.1 503910 R 28985 CDS KLLA0_D05907g 2893463 complement(505826..506707) D 1 NC_006040.1 similar to uniprot|P34251 Saccharomyces cerevisiae YKL107W Hypothetical ORF; uncharacterized protein 506707 2893463 KLLA0_D05907g Kluyveromyces lactis uncharacterized protein XP_453325.1 505826 R 28985 CDS KLLA0_D05929g 2893423 507555..508784 D 1 NC_006040.1 highly similar to uniprot|P07267 Saccharomyces cerevisiae YPL154C PEP4 Vacuolar aspartyl protease (proteinase A) required for the posttranslational precursor maturation of vacuolar proteinases synthesized as a zymogen self-activates; proteinase A 508784 2893423 KLLA0_D05929g Kluyveromyces lactis proteinase A XP_453326.1 507555 D 28985 CDS KLLA0_D05951g 2893394 509713..511719 D 1 NC_006040.1 similar to uniprot|P28743 Saccharomyces cerevisiae YPL155C KIP2 Kinesin-related motor protein involved in mitotic spindle positioning; uncharacterized protein 511719 2893394 KLLA0_D05951g Kluyveromyces lactis uncharacterized protein XP_453327.1 509713 D 28985 CDS KLLA0_D05973g 2893516 512611..513456 D 1 NC_006040.1 some similarities with uniprot|Q12498 Saccharomyces cerevisiae YPL156C PRM4 Pheromone-regulated protein predicted to have 1 transmembrane segment transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift; pheromone-regulated protein PRM4 513456 2893516 KLLA0_D05973g Kluyveromyces lactis pheromone-regulated protein PRM4 XP_453328.1 512611 D 28985 CDS KLLA0_D05995g 2893610 complement(513734..514645) D 1 NC_006040.1 similar to uniprot|Q12052 Saccharomyces cerevisiae YPL157W TGS1 TrimethylGuanosine Synthase; RNA methyltransferase 514645 2893610 KLLA0_D05995g Kluyveromyces lactis RNA methyltransferase XP_453329.1 513734 R 28985 CDS KLLA0_D06017g 2893533 516038..517816 D 1 NC_006040.1 weakly similar to uniprot|Q99299 Saccharomyces cerevisiae YPL158C Hypothetical ORF; uncharacterized protein 517816 2893533 KLLA0_D06017g Kluyveromyces lactis uncharacterized protein XP_453330.1 516038 D 28985 CDS KLLA0_D06039g 2893234 complement(518035..519357) D 1 NC_006040.1 similar to uniprot|Q03649 Saccharomyces cerevisiae YMR210W Hypothetical ORF; uncharacterized protein 519357 2893234 KLLA0_D06039g Kluyveromyces lactis uncharacterized protein XP_453331.1 518035 R 28985 CDS KLLA0_D06061g 2892758 520082..520831 D 1 NC_006040.1 weakly similar to uniprot|Q99373 Saccharomyces cerevisiae YPL159C PET20 Protein required for respiratory growth and stability of the mitochondrial genome; uncharacterized protein 520831 2892758 KLLA0_D06061g Kluyveromyces lactis uncharacterized protein XP_453332.1 520082 D 28985 CDS KLLA0_D06083g 2892707 complement(521215..521565) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 521565 2892707 KLLA0_D06083g Kluyveromyces lactis uncharacterized protein XP_453333.1 521215 R 28985 CDS KLLA0_D06105g 2892696 complement(522480..525767) D 1 NC_006040.1 highly similar to uniprot|P26637 Saccharomyces cerevisiae YPL160W CDC60 Cytosolic leucyl tRNA synthetase ligates leucine to the appropriate tRNA; leucine--tRNA ligase CDC60 525767 2892696 KLLA0_D06105g Kluyveromyces lactis leucine--tRNA ligase CDC60 XP_453334.1 522480 R 28985 CDS KLLA0_D06127g 2892715 complement(526164..527156) D 1 NC_006040.1 similar to uniprot|Q08651 Saccharomyces cerevisiae YOR246C Protein with similarity to oxidoreductases; uncharacterized protein 527156 2892715 KLLA0_D06127g Kluyveromyces lactis uncharacterized protein XP_453335.1 526164 R 28985 CDS KLLA0_D06149g 2892851 527705..528754 D 1 NC_006040.1 similar to uniprot|Q03289 Saccharomyces cerevisiae YDR459C likely functions in pathway(s) outside Ras; palmitoyltransferase PFA5 528754 2892851 KLLA0_D06149g Kluyveromyces lactis palmitoyltransferase PFA5 XP_453336.1 527705 D 28985 CDS KLLA0_D06171g 2892744 complement(528904..531318) D 1 NC_006040.1 similar to uniprot|P15274 Saccharomyces cerevisiae YML035C AMD1 AMP deaminase tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia may be involved in regulation of intracellular adenine nucleotide pools; uncharacterized protein 531318 2892744 KLLA0_D06171g Kluyveromyces lactis uncharacterized protein XP_453337.1 528904 R 28985 CDS KLLA0_D06193g 2892718 complement(531646..532026) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 532026 2892718 KLLA0_D06193g Kluyveromyces lactis uncharacterized protein XP_453338.1 531646 R 28985 CDS KLLA0_D06215g 2892886 532434..533144 D 1 NC_006040.1 similar to uniprot|P40586 Saccharomyces cerevisiae YIR042C Hypothetical ORF; uncharacterized protein 533144 2892886 KLLA0_D06215g Kluyveromyces lactis uncharacterized protein XP_453339.1 532434 D 28985 CDS KLLA0_D06237g 2892840 complement(533640..535472) D 1 NC_006040.1 similar to uniprot|P32864 Saccharomyces cerevisiae YOR370C MRS6 Rab escort protein forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); GTPase-activating protein MRS6 535472 2892840 KLLA0_D06237g Kluyveromyces lactis GTPase-activating protein MRS6 XP_453340.1 533640 R 28985 CDS KLLA0_D06259g 2892837 complement(536532..538877) D 1 NC_006040.1 similar to uniprot|P40309 Saccharomyces cerevisiae YJL094C KHA1 Putative K /H antiporter; uncharacterized protein 538877 2892837 KLLA0_D06259g Kluyveromyces lactis uncharacterized protein XP_453341.1 536532 R 28985 CDS KLLA0_D06281g 2892868 540031..542289 D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 542289 2892868 KLLA0_D06281g Kluyveromyces lactis uncharacterized protein XP_453342.1 540031 D 28985 CDS KLLA0_D06303g 2892782 542884..543486 D 1 NC_006040.1 similar to uniprot|Q08873 Saccharomyces cerevisiae YOR367W; uncharacterized protein 543486 2892782 KLLA0_D06303g Kluyveromyces lactis uncharacterized protein XP_453343.1 542884 D 28985 CDS KLLA0_D06380g 2892973 complement(544437..545738) D 1 NC_006040.1 similar to uniprot|P38355 Saccharomyces cerevisiae YBR287W ZSP1; uncharacterized protein 545738 2892973 KLLA0_D06380g Kluyveromyces lactis uncharacterized protein XP_453345.1 544437 R 28985 CDS KLLA0_D06402g 2893046 547385..549280 D 1 NC_006040.1 weakly similar to uniprot|P40358 Saccharomyces cerevisiae YJL073W JEM1 DnaJ-like chaperone required for nuclear membrane fusion during mating localizes to the ER membrane exhibits genetic interactions with KAR2; uncharacterized protein 549280 2893046 KLLA0_D06402g Kluyveromyces lactis uncharacterized protein XP_453346.1 547385 D 28985 CDS KLLA0_D06424g 2893078 complement(549532..551109) D 1 NC_006040.1 similar to uniprot|P37302 Saccharomyces cerevisiae YBR286W APE3 Vacuolar aminopeptidase Y processed to mature form by Prb1p; aminopeptidase Y 551109 2893078 KLLA0_D06424g Kluyveromyces lactis aminopeptidase Y XP_453347.1 549532 R 28985 CDS KLLA0_D06446g 2893079 complement(551644..555915) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 555915 2893079 KLLA0_D06446g Kluyveromyces lactis uncharacterized protein XP_453348.1 551644 R 28985 CDS KLLA0_D06479g 2893081 complement(556926..557447) D 1 NC_006040.1 no similarity; uncharacterized protein 557447 2893081 KLLA0_D06479g Kluyveromyces lactis uncharacterized protein XP_453350.1 556926 R 28985 CDS KLLA0_D06501g 2893202 complement(558598..559203) D 1 NC_006040.1 similar to uniprot|P40359 Saccharomyces cerevisiae YJL072C PSF2 Subunit of the GINS complex (Sld5p Psf1p Psf2p Psf3p) which binds to DNA replication origins and facilitates assembly of the DNA replication machinery; DNA replication protein PSF2 559203 2893202 KLLA0_D06501g Kluyveromyces lactis DNA replication protein PSF2 XP_453351.1 558598 R 28985 CDS KLLA0_D06523g 2893520 559526..561184 D 1 NC_006040.1 similar to uniprot|P40360 Saccharomyces cerevisiae YJL071W ARG2 Acetylglutamate synthase (glutamate N-acetyltransferase) mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine forms a complex with Arg5 6p; acetyl-CoA:L-glutamate N-acetyltransferase 561184 2893520 KLLA0_D06523g Kluyveromyces lactis acetyl-CoA:L-glutamate N-acetyltransferase XP_453352.1 559526 D 28985 CDS KLLA0_D06567g 2893049 562063..563340 D 1 NC_006040.1 similar to uniprot|Q02933 Saccharomyces cerevisiae YPL123C RNY1 RNAse member of the T(2) family of endoribonucleases; ribonuclease T2 563340 2893049 KLLA0_D06567g Kluyveromyces lactis ribonuclease T2 XP_453353.1 562063 D 28985 CDS KLLA0_D06589g 2893158 complement(563451..564272) D 1 NC_006040.1 some similarities with uniprot|P33419 Saccharomyces cerevisiae YPL124W SPC29 Inner plaque spindle pole body (SPB) component; uncharacterized protein 564272 2893158 KLLA0_D06589g Kluyveromyces lactis uncharacterized protein XP_453354.1 563451 R 28985 CDS KLLA0_D06611g 2893267 565742..568453 D 1 NC_006040.1 similar to uniprot|P29461 Saccharomyces cerevisiae YOR208W PTP2 Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing dephosporylates Hog1p MAPK and regulates its localization localized to the nucleus; tyrosine protein phosphatase PTP2 568453 2893267 KLLA0_D06611g Kluyveromyces lactis tyrosine protein phosphatase PTP2 XP_453355.1 565742 D 28985 CDS KLLA0_D06633g 2893523 complement(568539..571610) D 1 NC_006040.1 similar to uniprot|Q02932 Saccharomyces cerevisiae YPL125W KAP120 Karyopherin with a role in the assembly or export of 60S ribosomal subunits; uncharacterized protein 571610 2893523 KLLA0_D06633g Kluyveromyces lactis uncharacterized protein XP_453356.1 568539 R 28985 CDS KLLA0_D06655g 2893586 complement(572219..573502) D 1 NC_006040.1 highly similar to uniprot|P39683 Saccharomyces cerevisiae YOR209C NPT1 Nicotinate phosphoribosyltransferase; nicotinate phosphoribosyltransferase 573502 2893586 KLLA0_D06655g Kluyveromyces lactis nicotinate phosphoribosyltransferase XP_453357.1 572219 R 28985 CDS KLLA0_D06677g 2892764 complement(574289..576844) D 1 NC_006040.1 similar to uniprot|Q02931 YPL126W Saccharomyces cerevisiae NAN1 U3 snoRNP protein component of the small (ribosomal) subunit (SSU) processosome containing U3; uncharacterized protein 576844 2892764 KLLA0_D06677g Kluyveromyces lactis uncharacterized protein XP_453358.1 574289 R 28985 CDS KLLA0_D06699g 2892808 577334..577546 D 1 NC_006040.1 highly similar to uniprot|P22139 Saccharomyces cerevisiae YOR210W RPB10 RNA polymerase subunit ABC10-beta common to RNA polymerases I II and III; DNA-directed RNA polymerase core subunit RPB10 577546 2892808 KLLA0_D06699g Kluyveromyces lactis DNA-directed RNA polymerase core subunit RPB10 XP_453359.1 577334 D 28985 CDS KLLA0_D06721g 2892882 complement(578072..580723) D 1 NC_006040.1 similar to uniprot|P32266 YOR211C Saccharomyces cerevisiae MGM1 Mitochondrial GTPase related to dynamin present in a complex containing Ugo1p and Fzo1p; dynamin-related GTPase MGM1 580723 2892882 KLLA0_D06721g Kluyveromyces lactis dynamin-related GTPase MGM1 XP_453360.1 578072 R 28985 CDS KLLA0_D06765g 2892959 583615..585036 D 1 NC_006040.1 weakly similar to uniprot|Q02457 YPL128C Saccharomyces cerevisiae TBF1 TTAGGG repeat binding factor; uncharacterized protein 585036 2892959 KLLA0_D06765g Kluyveromyces lactis uncharacterized protein XP_453362.1 583615 D 28985 CDS KLLA0_D06787g 2892893 586289..587599 D 1 NC_006040.1 similar to uniprot|P18851 YOR212W Saccharomyces cerevisiae STE4 G protein beta subunit; G protein subunit beta 587599 2892893 KLLA0_D06787g Kluyveromyces lactis G protein subunit beta XP_453363.1 586289 D 28985 CDS KLLA0_D06809g 2893062 complement(587709..588275) D 1 NC_006040.1 similar to uniprot|Q75C19 Ashbya gossypii ACR098C ACR098Cp and some similarites with YPL129W uniprot|P35189 Saccharomyces cerevisiae YPL129W TAF14 Subunit (30 kDa) of TFIID TFIIF and SWI/SNF complexes involved in RNA polymerase II transcription initiation and in chromatin modification contains a YEATS domain; uncharacterized protein 588275 2893062 KLLA0_D06809g Kluyveromyces lactis uncharacterized protein XP_453364.1 587709 R 28985 CDS KLLA0_D06831g 2893065 complement(join(588834..589595,589704..589712)) D 1 NC_006040.1 similar to uniprot|P35189 Saccharomyces cerevisiae YPL129W TAF14 Subunit(30 kDa) of TFIID, TFIIF, and SWI/SNF complexes,involved in RNA polymerase II transcription initiation and in chromatin modification, contains a YEATS domain; uncharacterized protein 589712 2893065 KLLA0_D06831g Kluyveromyces lactis uncharacterized protein XP_453365.1 588834 R 28985 CDS KLLA0_D06853g 2893217 complement(590221..590778) D 1 NC_006040.1 similar to uniprot|Q12032 YOR215C Saccharomyces cerevisiae Hypothetical ORF; uncharacterized protein 590778 2893217 KLLA0_D06853g Kluyveromyces lactis uncharacterized protein XP_453366.1 590221 R 28985 CDS KLLA0_D06875g 2893243 complement(591141..592529) D 1 NC_006040.1 similar to uniprot|Q12234 YOR216C Saccharomyces cerevisiae RUD3 Golgi matrix protein that is involved in the structural organization of the cis-Golgi; uncharacterized protein 592529 2893243 KLLA0_D06875g Kluyveromyces lactis uncharacterized protein XP_453367.1 591141 R 28985 CDS KLLA0_D06897g 2893249 592913..595420 D 1 NC_006040.1 similar to uniprot|P38630 Saccharomyces cerevisiae YOR217W RFC1 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; replication factor C subunit 1 595420 2893249 KLLA0_D06897g Kluyveromyces lactis replication factor C subunit 1 XP_453368.1 592913 D 28985 CDS KLLA0_D06919g 2893254 complement(595450..598068) D 1 NC_006040.1 similar to uniprot|P33894 Saccharomyces cerevisiae YOR219C STE13 Dipeptidyl aminopeptidase Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences required for maturation of alpha factor transcription is induced by a-factor; uncharacterized protein 598068 2893254 KLLA0_D06919g Kluyveromyces lactis uncharacterized protein XP_453369.1 595450 R 28985 CDS KLLA0_D06941g 2893411 complement(598560..599453) D 1 NC_006040.1 highly similar to uniprot|P26321 Saccharomyces cerevisiae YPL131W RPL5 component of the large (60S) ribosomal subunit; 60S ribosomal protein uL18 599453 2893411 KLLA0_D06941g Kluyveromyces lactis 60S ribosomal protein uL18 XP_453370.1 598560 R 28985 CDS KLLA0_D06963g 2893448 599738..600223 D 1 NC_006040.1 no similarity; uncharacterized protein 600223 2893448 KLLA0_D06963g Kluyveromyces lactis uncharacterized protein XP_453371.1 599738 D 28985 CDS KLLA0_D06985g 2892830 600527..601303 D 1 NC_006040.1 similar to gnl|GLV|CAGL0J04158g Candida glabrata CAGL0J04158g and weakly similar to YOR220W uniprot|Q12044 Saccharomyces cerevisiae YOR220W Hypothetical ORF; uncharacterized protein 601303 2892830 KLLA0_D06985g Kluyveromyces lactis uncharacterized protein XP_453372.1 600527 D 28985 CDS KLLA0_D07007g 2892876 complement(601656..602441) D 1 NC_006040.1 similar to uniprot|P19516 YPL132W Saccharomyces cerevisiae COX11 Mitochondrial membrane protein required for assembly of active cytochrome c oxidase; uncharacterized protein 602441 2892876 KLLA0_D07007g Kluyveromyces lactis uncharacterized protein XP_453373.1 601656 R 28985 CDS KLLA0_D07029g 2892736 602763..604367 D 1 NC_006040.1 similar to uniprot|P19541 Saccharomyces cerevisiae YPL133C RDS2 Regulator of drug sensitivity Transcriptional regulator; gluconeogenesis transcription factor RDS2 604367 2892736 KLLA0_D07029g Kluyveromyces lactis gluconeogenesis transcription factor RDS2 XP_453374.1 602763 D 28985 CDS KLLA0_D07051g 2892801 complement(604505..605476) D 1 NC_006040.1 similar to uniprot|Q12283 Saccharomyces cerevisiae YOR221C MCT1 Predicted malonyl-CoA:ACP transferase putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling; [acyl-carrier-protein] S-malonyltransferase 605476 2892801 KLLA0_D07051g Kluyveromyces lactis [acyl-carrier-protein] S-malonyltransferase XP_453375.1 604505 R 28985 CDS KLLA0_D07073g 2892787 606857..607750 D 1 NC_006040.1 similar to uniprot|Q03028 Saccharomyces cerevisiae YPL134C ODC1 Mitochondrial inner membrane transporter exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism; uncharacterized protein 607750 2892787 KLLA0_D07073g Kluyveromyces lactis uncharacterized protein XP_453376.1 606857 D 28985 CDS KLLA0_D07095g 2892875 608975..609715 D 1 NC_006040.1 similar to uniprot|Q12015 Saccharomyces cerevisiae YOR223W Hypothetical ORF; uncharacterized protein 609715 2892875 KLLA0_D07095g Kluyveromyces lactis uncharacterized protein XP_453377.1 608975 D 28985 CDS KLLA0_D07117g 2893001 complement(609913..610569) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 610569 2893001 KLLA0_D07117g Kluyveromyces lactis uncharacterized protein XP_453378.1 609913 R 28985 CDS KLLA0_D07139g 2892934 complement(611102..611539) D 1 NC_006040.1 highly similar to uniprot|P20436 Saccharomyces cerevisiae YOR224C RPB8 RNA polymerase subunit ABC14.5 common to RNA polymerases I II and III; DNA-directed RNA polymerase core subunit RPB8 611539 2892934 KLLA0_D07139g Kluyveromyces lactis DNA-directed RNA polymerase core subunit RPB8 XP_453379.1 611102 R 28985 CDS KLLA0_D07161g 2893074 complement(612348..612890) D 1 NC_006040.1 similar to uniprot|Q03020 Saccharomyces cerevisiae YPL135W ISU1 Conserved protein of the mitochondrial matrix; uncharacterized protein 612890 2893074 KLLA0_D07161g Kluyveromyces lactis uncharacterized protein XP_453380.1 612348 R 28985 CDS KLLA0_D07216g 2893071 614450..618286 D 1 NC_006040.1 similar to uniprot|Q12276 Saccharomyces cerevisiae YOR227W Hypothetical ORF; uncharacterized protein 618286 2893071 KLLA0_D07216g Kluyveromyces lactis uncharacterized protein XP_453383.1 614450 D 28985 CDS KLLA0_D07238g 2893153 complement(618435..619286) D 1 NC_006040.1 similar to uniprot|Q12106 Saccharomyces cerevisiae Hypothetical ORF; uncharacterized protein 619286 2893153 KLLA0_D07238g Kluyveromyces lactis uncharacterized protein XP_453384.1 618435 R 28985 CDS KLLA0_D07260g 2893174 619630..620658 D 1 NC_006040.1 similar to uniprot|Q03012 Saccharomyces cerevisiae YPL138C SPP1 Subunit of the COMPASS complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; uncharacterized protein 620658 2893174 KLLA0_D07260g Kluyveromyces lactis uncharacterized protein XP_453385.1 619630 D 28985 CDS KLLA0_D07282g 2893268 621115..622467 D 1 NC_006040.1 similar to gnl|GLV|CAGL0M02563g Candida glabrata CAGL0M02563g and weakly similar to uniprot|Q12206 YOR229W Saccharomyces cerevisiae WTM2 WD repeat containing transcriptional modulator 2; uncharacterized protein 622467 2893268 KLLA0_D07282g Kluyveromyces lactis uncharacterized protein XP_453386.1 621115 D 28985 CDS KLLA0_D07304g 2893278 623352..624749 D 1 NC_006040.1 some similarities with uniprot|P32490 Saccharomyces cerevisiae YOR231W MKK1 Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity upon activation by Bck1p phosphorylates downstream target Slt2p functionally redundant with Mkk2p; mitogen-activated protein kinase kinase MKK1 624749 2893278 KLLA0_D07304g Kluyveromyces lactis mitogen-activated protein kinase kinase MKK1 XP_453387.1 623352 D 28985 CDS KLLA0_D07326g 2893518 625107..625838 D 1 NC_006040.1 similar to uniprot|P38523 YOR232W Saccharomyces cerevisiae MGE1 Protein of the mitochondrial matrix involved in protein import into mitochondria; uncharacterized protein 625838 2893518 KLLA0_D07326g Kluyveromyces lactis uncharacterized protein XP_453388.1 625107 D 28985 CDS KLLA0_D07348g 2893535 626999..629728 D 1 NC_006040.1 similar to uniprot|Q03002 Saccharomyces cerevisiae YPL141C Hypothetical ORF; uncharacterized protein 629728 2893535 KLLA0_D07348g Kluyveromyces lactis uncharacterized protein XP_453389.1 626999 D 28985 CDS KLLA0_D07370g 2893548 complement(630095..631894) D 1 NC_006040.1 similar to uniprot|P40445 Saccharomyces cerevisiae YIL166C Hypothetical ORF; uncharacterized protein 631894 2893548 KLLA0_D07370g Kluyveromyces lactis uncharacterized protein XP_453390.1 630095 R 28985 CDS KLLA0_D07405g 2892749 complement(join(633063..633367,634009..634027)) D 1 NC_006040.1 highly similar to uniprot|P05744 Saccharomyces cerevisiae YPL143W RPL33A Ribosomal Protein of the Large subunit; 60S ribosomal protein eL33 634027 2892749 KLLA0_D07405g Kluyveromyces lactis 60S ribosomal protein eL33 XP_453392.1 633063 R 28985 CDS KLLA0_D07414g 2892742 complement(635851..637941) D 1 NC_006040.1 similar to uniprot|Q75BZ7 Ashbya gossypii ACR122C ACR122Cp and some similarities with YHR176W uniprot|P38866 Saccharomyces cerevisiae YHR176W FMO1 Flavin-containing monooxygenase localized to the cytoplasmic face of the ER membrane catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins; uncharacterized protein 637941 2892742 KLLA0_D07414g Kluyveromyces lactis uncharacterized protein XP_453393.1 635851 R 28985 CDS KLLA0_D07436g 2892938 complement(639179..639625) D 1 NC_006040.1 weakly similar to uniprot|Q6Q5F7 Saccharomyces cerevisiae YPL144W Hypothetical ORF; uncharacterized protein 639625 2892938 KLLA0_D07436g Kluyveromyces lactis uncharacterized protein XP_453394.1 639179 R 28985 CDS KLLA0_D07458g 2892927 639883..640581 D 1 NC_006040.1 similar to uniprot|P07807 Saccharomyces cerevisiae YOR236W DFR1 Dihydrofolate reductase part of the dTTP biosynthetic pathway involved in folate metabolism possibly required for mitochondrial function; dihydrofolate reductase 640581 2892927 KLLA0_D07458g Kluyveromyces lactis dihydrofolate reductase XP_453395.1 639883 D 28985 CDS KLLA0_D07480g 2892926 641278..642525 D 1 NC_006040.1 similar to uniprot|P35844 YPL145C Saccharomyces cerevisiae KES1 Member of the oxysterol binding protein family which includes seven yeast homologs involved in negative regulation of Sec14p-dependent Golgi complex secretory functions; oxysterol-binding protein related protein HES1 642525 2892926 KLLA0_D07480g Kluyveromyces lactis oxysterol-binding protein related protein HES1 XP_453396.1 641278 D 28985 CDS KLLA0_D07502g 2892899 complement(642751..646482) D 1 NC_006040.1 similar to uniprot|P32908 Saccharomyces cerevisiae YFL008W SMC1 Subunit of the multiprotein cohesin complex essential protein involved in chromosome segregation and in double-strand DNA break repair SMC chromosomal ATPase family member binds DNA with a preference for DNA with secondary structure; cohesin subunit SMC1 646482 2892899 KLLA0_D07502g Kluyveromyces lactis cohesin subunit SMC1 XP_453397.1 642751 R 28985 CDS KLLA0_D07524g 2892915 complement(647018..647425) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 647425 2892915 KLLA0_D07524g Kluyveromyces lactis uncharacterized protein XP_453398.1 647018 R 28985 CDS KLLA0_D07546g 2893122 complement(647984..649927) D 1 NC_006040.1 similar to uniprot|P07834 Saccharomyces cerevisiae YFL009W CDC4 F-box protein required for G1/S and G2/M transition associates with Skp1p and Cdc53p to form a complex SCFCdc4 which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p; SCF ubiquitin ligase complex subunit CDC4 649927 2893122 KLLA0_D07546g Kluyveromyces lactis SCF ubiquitin ligase complex subunit CDC4 XP_453399.1 647984 R 28985 CDS KLLA0_D07568g 2893156 650626..651738 D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 651738 2893156 KLLA0_D07568g Kluyveromyces lactis uncharacterized protein XP_453400.1 650626 D 28985 CDS KLLA0_D07579g 9487344 651918..652211 D 1 NC_006040.1 highly similar to uniprot|Q6D0Z1 Erwinia carotovora subsp ECA3657 Putative exported protein; uncharacterized protein 652211 9487344 KLLA0_D07579g Kluyveromyces lactis uncharacterized protein XP_002999371.1 651918 D 28985 CDS KLLA0_D07590g 2893220 652790..654859 D 1 NC_006040.1 similar to uniprot|Q750H9 Ashbya gossypii AGL028C AGL028Cp and weakly similar to YFL013C uniprot|P43579 Saccharomyces cerevisiae YFL013C IES1 Subunit of the INO80 chromatin remodeling complex; uncharacterized protein 654859 2893220 KLLA0_D07590g Kluyveromyces lactis uncharacterized protein XP_453401.1 652790 D 28985 CDS KLLA0_D07612g 2893227 complement(654909..655721) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 655721 2893227 KLLA0_D07612g Kluyveromyces lactis uncharacterized protein XP_453402.1 654909 R 28985 CDS KLLA0_D07634g 2893432 complement(656256..656576) D 1 NC_006040.1 similar to uniprot|P22943 Saccharomyces cerevisiae YFL014W HSP12 Plasma membrane localized protein that protects membranes from desiccation induced by heat shock oxidative stress osmostress stationary phase entry glucose depletion oleate and alcohol regulated by the HOG and Ras-Pka pathways; lipid-binding protein HSP12 656576 2893432 KLLA0_D07634g Kluyveromyces lactis lipid-binding protein HSP12 XP_453403.1 656256 R 28985 CDS KLLA0_D07656g 2893611 658179..659594 D 1 NC_006040.1 similar to uniprot|P35191 Saccharomyces cerevisiae YFL016C MDJ1 Protein involved in folding of mitochondrially synthesized proteins in the mitochondrial matrix localizes to the mitochondrial inner membrane member of the DnaJ family of molecular chaperones; uncharacterized protein 659594 2893611 KLLA0_D07656g Kluyveromyces lactis uncharacterized protein XP_453404.1 658179 D 28985 CDS KLLA0_D07678g 2893500 join(660137..660160,660239..660436) D 1 NC_006040.1 highly similar to uniprot|P40204 Saccharomyces cerevisiae YFL017W-A SMX2; mRNA splicing protein SMX2 660436 2893500 KLLA0_D07678g Kluyveromyces lactis mRNA splicing protein SMX2 XP_453405.2 660137 D 28985 CDS KLLA0_D07700g 2893532 complement(660561..661127) D 1 NC_006040.1 similar to uniprot|P43577 Saccharomyces cerevisiae YFL017C GNA1 Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START DNA synthesis and mitosis involved in UDP-N-acetylglucosamine synthesis forms GlcNAc6P from AcCoA; glucosamine 6-phosphate N-acetyltransferase 661127 2893532 KLLA0_D07700g Kluyveromyces lactis glucosamine 6-phosphate N-acetyltransferase XP_453406.1 660561 R 28985 CDS KLLA0_D07722g 2892884 complement(661143..661655) D 1 NC_006040.1 weakly similar to uniprot|Q12155 Saccharomyces cerevisiae YLR050C Hypothetical ORF; uncharacterized protein 661655 2892884 KLLA0_D07722g Kluyveromyces lactis uncharacterized protein XP_453407.1 661143 R 28985 CDS KLLA0_D07744g 2892721 complement(662166..663647) D 1 NC_006040.1 similar to uniprot|P41948 Saccharomyces cerevisiae YNL142W MEP2 Ammonium permease involved in regulation of pseudohyphal growth belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4) expression is under the nitrogen catabolite repression regulation; uncharacterized protein 663647 2892721 KLLA0_D07744g Kluyveromyces lactis uncharacterized protein XP_453408.1 662166 R 28985 CDS KLLA0_D07766g 2892835 complement(664947..666416) D 1 NC_006040.1 similar to uniprot|P41948 Saccharomyces cerevisiae YNL142W MEP2 Ammonium permease involved in regulation of pseudohyphal growth belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4) expression is under the nitrogen catabolite repression regulation; uncharacterized protein 666416 2892835 KLLA0_D07766g Kluyveromyces lactis uncharacterized protein XP_453409.1 664947 R 28985 CDS KLLA0_D07788g 2892785 667841..668506 D 1 NC_006040.1 similar to uniprot|P38842 Saccharomyces cerevisiae YHR140W Hypothetical ORF; uncharacterized protein 668506 2892785 KLLA0_D07788g Kluyveromyces lactis uncharacterized protein XP_453410.1 667841 D 28985 CDS KLLA0_D07810g 2893513 complement(669095..671251) D 1 NC_006040.1 some similarities with uniprot|P53894 Saccharomyces cerevisiae YNL161W CBK1 Protein kinase involved in cell wall biosynthesis required for efficient apical growth proper mating projection morphology bipolar bud site selection in diploid cells and cell separation; serine/threonine protein kinase CBK1 671251 2893513 KLLA0_D07810g Kluyveromyces lactis serine/threonine protein kinase CBK1 XP_453411.1 669095 R 28985 CDS KLLA0_D07832g 2892940 complement(join(671772..672088,672679..672682)) D 1 NC_006040.1 highly similar to uniprot|P02405 Saccharomyces cerevisiae YHR141C RPL42B Proteins component of the large (60S) ribosomal subunit; 60S ribosomal protein eL42 672682 2892940 KLLA0_D07832g Kluyveromyces lactis 60S ribosomal protein eL42 XP_453412.1 671772 R 28985 CDS KLLA0_D07854g 2892936 673829..674782 D 1 NC_006040.1 similar to uniprot|P38843 Saccharomyces cerevisiae YHR142W CHS7; uncharacterized protein 674782 2892936 KLLA0_D07854g Kluyveromyces lactis uncharacterized protein XP_453413.1 673829 D 28985 CDS KLLA0_D07876g 2893187 complement(674961..675176) D 1 NC_006040.1 similar to uniprot|Q3E7A8 Saccharomyces cerevisiae YNL162W-A; uncharacterized protein 675176 2893187 KLLA0_D07876g Kluyveromyces lactis uncharacterized protein XP_453414.1 674961 R 28985 CDS KLLA0_D07898g 2893525 675451..678831 D 1 NC_006040.1 similar to uniprot|P53893 Saccharomyces cerevisiae YNL163C RIA1 Cytoplasmic GTPase involved in biogenesis of the 60S ribosome; has similarity to translation elongation factor 2 (Eft1p and Eft2p); GTPase RIA1 678831 2893525 KLLA0_D07898g Kluyveromyces lactis GTPase RIA1 XP_453415.1 675451 D 28985 CDS KLLA0_D07920g 2893181 679160..680167 D 1 NC_006040.1 weakly similar to uniprot|P53892 Saccharomyces cerevisiae YNL164C IBD2 Component of the BUB2-dependent spindle checkpoint pathway interacts with Bfa1p and functions upstream of Bub2p and Bfa1p; uncharacterized protein 680167 2893181 KLLA0_D07920g Kluyveromyces lactis uncharacterized protein XP_453416.1 679160 D 28985 CDS KLLA0_D07942g 2893450 681139..681933 D 1 NC_006040.1 some similarities with uniprot|P38844 Sacharromyces cerevisiae YHR143W; uncharacterized protein 681933 2893450 KLLA0_D07942g Kluyveromyces lactis uncharacterized protein XP_453417.1 681139 D 28985 CDS KLLA0_D07964g 2892725 complement(682226..683278) D 1 NC_006040.1 weakly similar to uniprot|P53891 Saccharomyces cerevisiae YNL165W Hypothetical ORF; uncharacterized protein 683278 2892725 KLLA0_D07964g Kluyveromyces lactis uncharacterized protein XP_453418.1 682226 R 28985 CDS KLLA0_D07986g 2892826 683732..684730 D 1 NC_006040.1 similar to uniprot|P53890 Saccharomyces cerevisiae YNL166C BNI5 Protein involved in organization of septins at the mother-bud neck may interact directly with the Cdc11p septin localizes to bud neck in a septin-dependent manner; uncharacterized protein 684730 2892826 KLLA0_D07986g Kluyveromyces lactis uncharacterized protein XP_453419.1 683732 D 28985 CDS KLLA0_D08008g 2892762 684998..685210 D 1 NC_006040.1 highly similar to uniprot|P40422 Saccharomyces cerevisiae YHR143W-A RPC10 RNA polymerase subunit ABC10-alpha common to RNA polymerases I II and III; DNA-directed RNA polymerase core subunit RPC10 685210 2892762 KLLA0_D08008g Kluyveromyces lactis DNA-directed RNA polymerase core subunit RPC10 XP_453420.1 684998 D 28985 CDS KLLA0_D08030g 2893553 685876..687540 D 1 NC_006040.1 weakly similar to uniprot|Q02100 Saccharomyces cerevisiae YNL167C SKO1; uncharacterized protein 687540 2893553 KLLA0_D08030g Kluyveromyces lactis uncharacterized protein XP_453421.1 685876 D 28985 CDS KLLA0_D08052g 2892757 687922..688707 D 1 NC_006040.1 highly similar to uniprot|P53889 Saccharomyces cerevisiae YNL168C FMP41 The authentic non-tagged protein was localized to mitochondria; uncharacterized protein 688707 2892757 KLLA0_D08052g Kluyveromyces lactis uncharacterized protein XP_453422.1 687922 D 28985 CDS KLLA0_D08074g 2892789 complement(688785..689807) D 1 NC_006040.1 similar to uniprot|P06773 Saccharomyces cerevisiae YHR144C DCD1 Deaminase required for dCTP and dTTP synthesis expression is cell cycle regulated; deoxycytidine monophosphate deaminase 689807 2892789 KLLA0_D08074g Kluyveromyces lactis deoxycytidine monophosphate deaminase XP_453423.1 688785 R 28985 CDS KLLA0_D08096g 2893570 690272..691750 D 1 NC_006040.1 similar to uniprot|P39006 Saccharomyces cerevisiae YNL169C PSD1 Phosphatidylserine decarboxylase of the mitochondrial inner membrane converts phosphatidylserine to phosphatidylethanolamine; phosphatidylserine decarboxylase 1 691750 2893570 KLLA0_D08096g Kluyveromyces lactis phosphatidylserine decarboxylase 1 XP_453424.1 690272 D 28985 CDS KLLA0_D08118g 2892923 complement(691907..696760) D 1 NC_006040.1 similar to uniprot|Q754Q1 Ashbya gossypii AFR021W AFR021Wp and weakly similar to YNL172W uniprot|P53886 Saccharomyces cerevisiae YNL172W APC1 Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition; anaphase promoting complex subunit 1 696760 2892923 KLLA0_D08118g Kluyveromyces lactis anaphase promoting complex subunit 1 XP_453425.1 691907 R 28985 CDS KLLA0_D08184g 2892943 698125..699495 D 1 NC_006040.1 weakly similar to uniprot|P38845 Saccharomyces cerevisiae YHR146W CRP1 Protein that binds to cruciform DNA structures; uncharacterized protein 699495 2892943 KLLA0_D08184g Kluyveromyces lactis uncharacterized protein XP_453426.1 698125 D 28985 CDS KLLA0_D08206g 2892916 700152..701327 D 1 NC_006040.1 similar to uniprot|P53883 Saccharomyces cerevisiae YNL175C NOP13 Protein of unknown function, localizes to the nucleolus and nucleoplasm; contains an RNA recognition motif (RRM) and has similarity to Nop12p, which is required for processing of pre-18S rRNA; uncharacterized protein 701327 2892916 KLLA0_D08206g Kluyveromyces lactis uncharacterized protein XP_453427.1 700152 D 28985 CDS KLLA0_D08239g 2893160 701887..703053 D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 703053 2893160 KLLA0_D08239g Kluyveromyces lactis uncharacterized protein XP_453429.1 701887 D 28985 CDS KLLA0_D08261g 2893185 703455..704354 D 1 NC_006040.1 similar to uniprot|P53881 Saccharomyces cerevisiae YNL177C MRPL22 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein uL22m 704354 2893185 KLLA0_D08261g Kluyveromyces lactis mitochondrial 54S ribosomal protein uL22m XP_453430.1 703455 D 28985 CDS KLLA0_D08283g 2893191 complement(704597..705205) D 1 NC_006040.1 similar to uniprot|Q02774 Saccharomyces cerevisiae YDL212W SHR3 Endoplasmic reticulum packaging chaperone required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface; uncharacterized protein 705205 2893191 KLLA0_D08283g Kluyveromyces lactis uncharacterized protein XP_453431.1 704597 R 28985 CDS KLLA0_D08305g 2893244 complement(705625..706338) D 1 NC_006040.1 highly similar to uniprot|P05750 Saccharomyces cerevisiae YNL178W RPS3 Protein component of the small (40S) ribosomal subunit; 40S ribosomal protein uS3 706338 2893244 KLLA0_D08305g Kluyveromyces lactis 40S ribosomal protein uS3 XP_453432.1 705625 R 28985 CDS KLLA0_D08327g 2893221 708240..709004 D 1 NC_006040.1 similar to gnl|GLV|DEHA0F04004g Debaryomyces hansenii DEHA0F04004g and weakly similar to YNL180C uniprot|P53879 Saccharomyces cerevisiae YNL180C RHO5 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity; Rho family GTPase RHO5 709004 2893221 KLLA0_D08327g Kluyveromyces lactis Rho family GTPase RHO5 XP_453433.1 708240 D 28985 CDS KLLA0_D08349g 2893262 complement(709391..710608) D 1 NC_006040.1 similar to uniprot|P53878 Saccharomyces cerevisiae YNL181W Protein required for cell viability; uncharacterized protein 710608 2893262 KLLA0_D08349g Kluyveromyces lactis uncharacterized protein XP_453434.1 709391 R 28985 CDS KLLA0_D08371g 2893425 710885..712411 D 1 NC_006040.1 similar to uniprot|P53877 Saccharomyces cerevisiae YNL182C IPI3 Protein required for cell viability computational analysis of large-scale protein-protein interaction data suggests a possible role in assembly of the ribosomal large subunit; chromatin-binding/pre-rRNA-processing protein IPI3 712411 2893425 KLLA0_D08371g Kluyveromyces lactis chromatin-binding/pre-rRNA-processing protein IPI3 XP_453435.1 710885 D 28985 CDS KLLA0_D08393g 2893598 712747..713409 D 1 NC_006040.1 some similarities with uniprot|Q07623 Saccharomyces cerevisiae YDL213C; uncharacterized protein 713409 2893598 KLLA0_D08393g Kluyveromyces lactis uncharacterized protein XP_453436.1 712747 D 28985 CDS KLLA0_D08415g 2893401 714473..716797 D 1 NC_006040.1 similar to uniprot|P22211 Saccharomyces cerevisiae YNL183C NPR1 Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; serine/threonine protein kinase NPR1 716797 2893401 KLLA0_D08415g Kluyveromyces lactis serine/threonine protein kinase NPR1 XP_453437.1 714473 D 28985 CDS KLLA0_D08437g 2893006 717270..717719 D 1 NC_006040.1 similar to uniprot|P53875 Saccharomyces cerevisiae YNL185C MRPL19 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein uL11m 717719 2893006 KLLA0_D08437g Kluyveromyces lactis mitochondrial 54S ribosomal protein uL11m XP_453438.1 717270 D 28985 CDS KLLA0_D08459g 2893253 complement(718046..720298) D 1 NC_006040.1 some similarities with uniprot|P53874 Saccharomyces cerevisiae YNL186W UBP10 Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties may regulate silencing by acting on Sir4p involved in posttranscriptionally regulating Gap1p and possibly other transporters primarily located in the nucleus; ubiquitin-specific protease UBP10 720298 2893253 KLLA0_D08459g Kluyveromyces lactis ubiquitin-specific protease UBP10 XP_453439.1 718046 R 28985 CDS KLLA0_D08481g 2893422 722139..725237 D 1 NC_006040.1 similar to uniprot|P33327 Saccharomyces cerevisiae YDL215C GDH2 NAD()-dependent glutamate dehydrogenase degrades glutamate to ammonia and alpha-ketoglutarate expression sensitive to nitrogen catabolite repression and intracellular ammonia levels; glutamate dehydrogenase (NAD(+)) 725237 2893422 KLLA0_D08481g Kluyveromyces lactis glutamate dehydrogenase (NAD(+)) XP_453440.1 722139 D 28985 CDS KLLA0_D08503g 2892990 725605..726726 D 1 NC_006040.1 some similarities with uniprot|Q12468 Saccharomyces cerevisiae YDL216C RRI1 subunit of COP9 signalosome (CSN) COP9 signalosome; COP9 signalosome catalytic subunit RRI1 726726 2892990 KLLA0_D08503g Kluyveromyces lactis COP9 signalosome catalytic subunit RRI1 XP_453441.1 725605 D 28985 CDS KLLA0_D08514g 2892901 complement(726710..727945) D 1 NC_006040.1 similar to uniprot|P53873 Saccharomyces cerevisiae YNL187W Non-essential protein with putative leucine-rich nuclear export signal (NES) sequence that fits the consensus sequence recognized by Crm1p; uncharacterized protein 727945 2892901 KLLA0_D08514g Kluyveromyces lactis uncharacterized protein XP_453442.1 726710 R 28985 CDS KLLA0_D08536g 2892887 728219..728809 D 1 NC_006040.1 highly similar to uniprot|Q12328 Saccharomyces cerevisiae YDL217C TIM22 Mitochondrial inner membrane protein involved in import of proteins of the ADP/ATP carrier (AAC) family; translocation channel protein TIM22 728809 2892887 KLLA0_D08536g Kluyveromyces lactis translocation channel protein TIM22 XP_453443.1 728219 D 28985 CDS KLLA0_D08558g 2892807 complement(728936..729700) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 729700 2892807 KLLA0_D08558g Kluyveromyces lactis uncharacterized protein XP_453444.1 728936 R 28985 CDS KLLA0_D08580g 2892712 complement(730189..731805) D 1 NC_006040.1 highly similar to uniprot|Q02821 Saccharomyces cerevisiae YNL189W SRP1 karyopherin alpha homolog of 60 kDa; karyopherin alpha 731805 2892712 KLLA0_D08580g Kluyveromyces lactis karyopherin alpha XP_453445.1 730189 R 28985 CDS KLLA0_D08624g 2892950 complement(733382..733897) D 1 NC_006040.1 some similarities with uniprot|P53872 Saccharomyces cerevisiae YNL190W Hypothetical ORF; uncharacterized protein 733897 2892950 KLLA0_D08624g Kluyveromyces lactis uncharacterized protein XP_453447.1 733382 R 28985 CDS KLLA0_D08646g 2892909 complement(734915..735775) D 1 NC_006040.1 weakly similar to uniprot|Q7LGR3 Saccharomyces cerevisiae YDL218W; uncharacterized protein 735775 2892909 KLLA0_D08646g Kluyveromyces lactis uncharacterized protein XP_453448.1 734915 R 28985 CDS KLLA0_D08668g 2892975 complement(737071..738165) D 1 NC_006040.1 similar to uniprot|P53871 Saccharomyces cerevisiae YNL191W Hypothetical ORF; glutamine amidotransferase subunit DUG3 738165 2892975 KLLA0_D08668g Kluyveromyces lactis glutamine amidotransferase subunit DUG3 XP_453449.1 737071 R 28985 CDS KLLA0_D08690g 2893082 complement(738466..738918) D 1 NC_006040.1 highly similar to uniprot|Q07648 Saccharomyces cerevisiae YDL219W DTD1 D-Tyr-tRNA(Tyr) deacylase functions in protein translation may affect nonsense suppression via alteration of the protein synthesis machinery ubiquitous among eukaryotes; D-tyrosyl-tRNA(Tyr) deacylase 738918 2893082 KLLA0_D08690g Kluyveromyces lactis D-tyrosyl-tRNA(Tyr) deacylase XP_453450.1 738466 R 28985 CDS KLLA0_D08712g 2893137 complement(739348..741447) D 1 NC_006040.1 similar to uniprot|P16603 Saccharomyces cerevisiae YHR042W NCP1 NADP-cytochrome P450 reductase involved in ergosterol biosynthesis associated and coordinately regulated with Erg11p; NADPH--hemoprotein reductase 741447 2893137 KLLA0_D08712g Kluyveromyces lactis NADPH--hemoprotein reductase XP_453451.1 739348 R 28985 CDS KLLA0_D08734g 2893129 complement(742009..742932) D 1 NC_006040.1 similar to uniprot|Q05541 Saccharomyces cerevisiae YDR288W NSE3 Essential protein of unknown function; Smc5-Smc6 complex subunit NSE3 742932 2893129 KLLA0_D08734g Kluyveromyces lactis Smc5-Smc6 complex subunit NSE3 XP_453452.1 742009 R 28985 CDS KLLA0_D08789g 2893225 complement(743690..744019) D 1 NC_006040.1 no similarity; uncharacterized protein 744019 2893225 KLLA0_D08789g Kluyveromyces lactis uncharacterized protein XP_453454.1 743690 R 28985 CDS KLLA0_D08811g 2893257 complement(744046..744615) D 1 NC_006040.1 similar to uniprot|P40892 Saccharomyces cerevisiae YJL218W Hypothetical ORF; acetyltransferase 744615 2893257 KLLA0_D08811g Kluyveromyces lactis acetyltransferase XP_453455.1 744046 R 28985 CDS KLLA0_D08833g 2893245 complement(745179..745304) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 745304 2893245 KLLA0_D08833g Kluyveromyces lactis uncharacterized protein XP_453456.2 745179 R 28985 CDS KLLA0_D08866g 2893390 745975..747300 D 1 NC_006040.1 similar to uniprot|P29704 Saccharomyces cerevisiae YHR190W ERG9 Farnesyl-diphosphate farnesyl transferase (squalene synthase) joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway; bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase 747300 2893390 KLLA0_D08866g Kluyveromyces lactis bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase XP_453457.1 745975 D 28985 CDS KLLA0_D08888g 2893542 complement(747666..750551) D 1 NC_006040.1 similar to uniprot|Q12751 Saccharomyces cerevisiae YMR185W Protein required for cell viability; uncharacterized protein 750551 2893542 KLLA0_D08888g Kluyveromyces lactis uncharacterized protein XP_453458.1 747666 R 28985 CDS KLLA0_D08910g 2892797 750828..751448 D 1 NC_006040.1 similar to uniprot|P46683 Saccharomyces cerevisiae YPL239W YAR1; uncharacterized protein 751448 2892797 KLLA0_D08910g Kluyveromyces lactis uncharacterized protein XP_453459.1 750828 D 28985 CDS KLLA0_D08932g 2892948 751943..752779 D 1 NC_006040.1 similar to uniprot|P09064 Saccharomyces cerevisiae YPL237W SUI3 Beta subunit of the translation initiation factor eIF2 involved in the identification of the start codon; translation initiation factor eIF2 subunit beta 752779 2892948 KLLA0_D08932g Kluyveromyces lactis translation initiation factor eIF2 subunit beta XP_453460.1 751943 D 28985 CDS KLLA0_D08954g 2892919 complement(753196..753723) D 1 NC_006040.1 similar to uniprot|Q755G7 Ashbya gossypii AFL144C AFL144Cp and weakly similar to YMR184W uniprot|Q03233 Saccharomyces cerevisiae YMR184W Hypothetical ORF; uncharacterized protein 753723 2892919 KLLA0_D08954g Kluyveromyces lactis uncharacterized protein XP_453461.1 753196 R 28985 CDS KLLA0_D08976g 2892966 755870..756586 D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 756586 2892966 KLLA0_D08976g Kluyveromyces lactis uncharacterized protein XP_453462.1 755870 D 28985 CDS KLLA0_D08998g 2893556 complement(756649..758505) D 1 NC_006040.1 weakly similar to uniprot|P38273 Saccharomyces cerevisiae YBR131W CCZ1 Protein involved in vacuolar assembly; uncharacterized protein 758505 2893556 KLLA0_D08998g Kluyveromyces lactis uncharacterized protein XP_453463.1 756649 R 28985 CDS KLLA0_D09020g 2892804 758818..760410 D 1 NC_006040.1 similar to uniprot|P20424 Saccharomyces cerevisiae YPR088C SRP54 Signal recognition particle (SRP) subunit (homolog of mammalian SRP54) contains the signal sequence-binding activity of SRP interacts with the SRP RNA and mediates binding of SRP to signal receptor contains GTPase domain; RNA-binding signal recognition particle subunit SRP54 760410 2892804 KLLA0_D09020g Kluyveromyces lactis RNA-binding signal recognition particle subunit SRP54 XP_453464.1 758818 D 28985 CDS KLLA0_D09042g 2892922 760795..761832 D 1 NC_006040.1 some similarities with uniprot|P38272 Saccharomyces cerevisiae YBR130C SHE3 Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud also required for cortical ER inheritance; uncharacterized protein 761832 2892922 KLLA0_D09042g Kluyveromyces lactis uncharacterized protein XP_453465.1 760795 D 28985 CDS KLLA0_D09064g 2892716 762314..763231 D 1 NC_006040.1 similar to uniprot|P38271 Saccharomyces cerevisiae YBR129C OPY1 Protein of unknown function overproduction blocks cell cycle arrest in the presence of mating pheromone; uncharacterized protein 763231 2892716 KLLA0_D09064g Kluyveromyces lactis uncharacterized protein XP_453466.1 762314 D 28985 CDS KLLA0_D09086g 2892955 763408..764607 D 1 NC_006040.1 weakly similar to uniprot|Q06822 Saccharomyces cerevisiae YPR085C Protein required for cell viability; uncharacterized protein 764607 2892955 KLLA0_D09086g Kluyveromyces lactis uncharacterized protein XP_453467.1 763408 D 28985 CDS KLLA0_D09108g 2893132 complement(764634..765998) D 1 NC_006040.1 similar to uniprot|Q06821 Saccharomyces cerevisiae YPR084W Hypothetical ORF; uncharacterized protein 765998 2893132 KLLA0_D09108g Kluyveromyces lactis uncharacterized protein XP_453468.1 764634 R 28985 CDS KLLA0_D09130g 2893581 766400..767323 D 1 NC_006040.1 some similarities with uniprot|P38270 Saccharomyces cerevisiae YBR128C ATG14 Subunit of an autophagy-specific phosphatidylinositol 3-kinase complex (with Vps34p Vps15p and Vps30p) required for organization of a pre-autophagosomal structure ATG14 transcription is activated by Gln3p during nitrogen starvation; uncharacterized protein 767323 2893581 KLLA0_D09130g Kluyveromyces lactis uncharacterized protein XP_453469.1 766400 D 28985 CDS KLLA0_D09152g 2893138 767715..769268 D 1 NC_006040.1 highly similar to uniprot|P16140 Saccharomyces cerevisiae YBR127C VMA2 Vacuolar H ATPase regulatory subunit; H(+)-transporting V1 sector ATPase subunit B 769268 2893138 KLLA0_D09152g Kluyveromyces lactis H(+)-transporting V1 sector ATPase subunit B XP_453470.1 767715 D 28985 CDS KLLA0_D09174g 2893194 complement(769519..771084) D 1 NC_006040.1 similar to uniprot|Q06820 Saccharomyces cerevisiae YPR083W MDM36 Mitochondrial Distribution and Morphology; uncharacterized protein 771084 2893194 KLLA0_D09174g Kluyveromyces lactis uncharacterized protein XP_453471.1 769519 R 28985 CDS KLLA0_D09196g 2893237 772795..773673 D 1 NC_006040.1 similar to uniprot|P14682 Saccharomyces cerevisiae YDR054C CDC34 Ubiquitin-conjugating enzyme or E2 together with Skp1p Rbx1p Cdc53p and an F-box protein forms a ubiquitin-protein ligase called the SCF complex which regulates cell cycle progression by targeting key substrates for degradation; SCF E2 ubiquitin-protein ligase catalytic subunit CDC34 773673 2893237 KLLA0_D09196g Kluyveromyces lactis SCF E2 ubiquitin-protein ligase catalytic subunit CDC34 XP_453472.1 772795 D 28985 CDS KLLA0_D09218g 2893455 complement(774788..775198) D 1 NC_006040.1 no similarity; uncharacterized protein 775198 2893455 KLLA0_D09218g Kluyveromyces lactis uncharacterized protein XP_453473.1 774788 R 28985 CDS KLLA0_D09240g 2893600 complement(775848..778094) D 1 NC_006040.1 weakly similar to uniprot|P28006 Saccharomyces cerevisiae YOR178C GAC1 Regulatory subunit for Glc7p (protein phosphatase I) for glycogen synthesis regulatory role also predicted for glucose repression and ion homeostasis potential Cdc28p substrate; uncharacterized protein 778094 2893600 KLLA0_D09240g Kluyveromyces lactis uncharacterized protein XP_453474.1 775848 R 28985 CDS KLLA0_D09262g 2893501 780273..782513 D 1 NC_006040.1 similar to uniprot|P29496 Saccharomyces cerevisiae YLR274W CDC46 Component of the hexameric MCM complex which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase; MCM DNA helicase complex subunit MCM5 782513 2893501 KLLA0_D09262g Kluyveromyces lactis MCM DNA helicase complex subunit MCM5 XP_453475.1 780273 D 28985 CDS KLLA0_D09284g 2893060 782856..783188 D 1 NC_006040.1 highly similar to uniprot|Q06217 Saccharomyces cerevisiae YLR275W SMD2 U1 snRNP protein of the Sm class; mRNA splicing protein SMD2 783188 2893060 KLLA0_D09284g Kluyveromyces lactis mRNA splicing protein SMD2 XP_453476.1 782856 D 28985 CDS KLLA0_D09306g 2893061 783852..788465 D 1 NC_006040.1 similar to uniprot|P04821 Saccharomyces cerevisiae YLR310C CDC25 Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor) indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP required for progression through G1; Ras family guanine nucleotide exchange factor CDC25 788465 2893061 KLLA0_D09306g Kluyveromyces lactis Ras family guanine nucleotide exchange factor CDC25 XP_453477.1 783852 D 28985 CDS KLLA0_D09328g 2893056 complement(788565..791705) D 1 NC_006040.1 similar to uniprot|P38990 Saccharomyces cerevisiae YER129W PAK1 Upstream kinase for the SNF1 complex partially redundant function with Elm1p and Tos3p members of this family of kinases have functional orthology with LKB1 a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome; uncharacterized protein 791705 2893056 KLLA0_D09328g Kluyveromyces lactis uncharacterized protein XP_453478.1 788565 R 28985 CDS KLLA0_D09350g 2892992 complement(792405..794096) D 1 NC_006040.1 highly similar to uniprot|P47079 Saccharomyces cerevisiae YJL008C CCT8 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo; chaperonin-containing T-complex subunit CCT8 794096 2892992 KLLA0_D09350g Kluyveromyces lactis chaperonin-containing T-complex subunit CCT8 XP_453479.1 792405 R 28985 CDS KLLA0_D09394g 2892780 795025..797436 D 1 NC_006040.1 similar to uniprot|P47061 Saccharomyces cerevisiae YJL029C VPS53 Required for Vacuolar Protein Sorting Vps53p is a hydrophilic protein that is peripherally associated with the late Golgi and forms a stable complex with Vps52p and Vps54p.; uncharacterized protein 797436 2892780 KLLA0_D09394g Kluyveromyces lactis uncharacterized protein XP_453480.1 795025 D 28985 CDS KLLA0_D09416g 2892777 797743..798336 D 1 NC_006040.1 no similarity; uncharacterized protein 798336 2892777 KLLA0_D09416g Kluyveromyces lactis uncharacterized protein XP_453481.1 797743 D 28985 CDS KLLA0_D09438g 2892732 complement(798454..799044) D 1 NC_006040.1 highly similar to uniprot|P40958 Saccharomyces cerevisiae YJL030W MAD2 Component of the spindle-assembly checkpoint complex which delays the onset of anaphase in cells with defects in mitotic spindle assembly forms a complex with Mad1p; spindle checkpoint protein MAD2 799044 2892732 KLLA0_D09438g Kluyveromyces lactis spindle checkpoint protein MAD2 XP_453482.1 798454 R 28985 CDS KLLA0_D09460g 2892878 join(799233..799235,799325..800305) D 1 NC_006040.1 highly similar to uniprot|Q00618 Saccharomyces cerevisiae YJL031C BET4 Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p; Rab geranylgeranyltransferase BET4 800305 2892878 KLLA0_D09460g Kluyveromyces lactis Rab geranylgeranyltransferase BET4 XP_453483.2 799233 D 28985 CDS KLLA0_D09482g 2892735 complement(800338..801309) D 1 NC_006040.1 similar to uniprot|P46962 Saccharomyces cerevisiae YJL006C; uncharacterized protein 801309 2892735 KLLA0_D09482g Kluyveromyces lactis uncharacterized protein XP_453484.1 800338 R 28985 CDS KLLA0_D09504g 2892880 complement(801783..804095) D 1 NC_006040.1 highly similar to uniprot|P20448 Saccharomyces cerevisiae YJL033W HCA4 Putative nucleolar DEAD box RNA helicase high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis; RNA-dependent ATPase HCA4 804095 2892880 KLLA0_D09504g Kluyveromyces lactis RNA-dependent ATPase HCA4 XP_453485.1 801783 R 28985 CDS KLLA0_D09526g 2892848 804422..805075 D 1 NC_006040.1 similar to uniprot|Q07930 Saccharomyces cerevisiae YLR016C Hypothetical ORF; uncharacterized protein 805075 2892848 KLLA0_D09526g Kluyveromyces lactis uncharacterized protein XP_453486.1 804422 D 28985 CDS KLLA0_D09559g 2892944 complement(805863..807614) D 1 NC_006040.1 similar to uniprot|P16474 Saccharomyces cerevisiae YJL034W KAR2 ATPase involved in protein import into the ER also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins regulates the unfolded protein response via interaction with Ire1p; Hsp70 family ATPase KAR2 807614 2892944 KLLA0_D09559g Kluyveromyces lactis Hsp70 family ATPase KAR2 XP_453488.1 805863 R 28985 CDS KLLA0_D09581g 2892953 809203..810870 D 1 NC_006040.1 similar to uniprot|P38778 Saccharomyces cerevisiae YHR050W SMF2 Divalent metal ion transporter; divalent metal ion transporter SMF2 810870 2892953 KLLA0_D09581g Kluyveromyces lactis divalent metal ion transporter SMF2 XP_453489.1 809203 D 28985 CDS KLLA0_D09603g 2892908 811234..813696 D 1 NC_006040.1 weakly similar to uniprot|P46949 Saccharomyces cerevisiae YGR196C FYV8 Protein of unknown function required for survival upon exposure to K1 killer toxin; uncharacterized protein 813696 2892908 KLLA0_D09603g Kluyveromyces lactis uncharacterized protein XP_453490.1 811234 D 28985 CDS KLLA0_D09625g 2892925 complement(813773..814510) D 1 NC_006040.1 highly similar to uniprot|P46948 Saccharomyces cerevisiae YGR195W SKI6 superkiller ExtraCellular Mutant Ribosomal RNA Processing homolog of RNAse PH; exosome non-catalytic core subunit SKI6 814510 2892925 KLLA0_D09625g Kluyveromyces lactis exosome non-catalytic core subunit SKI6 XP_453491.1 813773 R 28985 CDS KLLA0_D09647g 2892962 complement(814829..816037) D 1 NC_006040.1 similar to uniprot|P47088 Saccharomyces cerevisiae YJR013W GPI14 Glycosylphosphatidylinositol-alpha 1 4 mannosyltransferase I involved in GPI anchor biosynthesis requires Pbn1p for function homolog of mammalian PIG-M; glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I 816037 2892962 KLLA0_D09647g Kluyveromyces lactis glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I XP_453492.1 814829 R 28985 CDS KLLA0_D09669g 2893075 816343..816750 D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 816750 2893075 KLLA0_D09669g Kluyveromyces lactis uncharacterized protein XP_453493.1 816343 D 28985 CDS KLLA0_D09691g 2893128 817452..818999 D 1 NC_006040.1 weakly similar to uniprot|P47084 Saccharomyces cerevisiae YJR003C Hypothetical ORF; uncharacterized protein 818999 2893128 KLLA0_D09691g Kluyveromyces lactis uncharacterized protein XP_453494.1 817452 D 28985 CDS KLLA0_D09713g 2893090 complement(819182..819817) D 1 NC_006040.1 no similarity; uncharacterized protein 819817 2893090 KLLA0_D09713g Kluyveromyces lactis uncharacterized protein XP_453495.1 819182 R 28985 CDS KLLA0_D09735g 2893141 820211..822199 D 1 NC_006040.1 similar to uniprot|Q92280 Saccharomyces cerevisiae YLR002C NOC3 Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport also binds to chromatin to promote the association of DNA replication factors and replication initiation; uncharacterized protein 822199 2893141 KLLA0_D09735g Kluyveromyces lactis uncharacterized protein XP_453496.1 820211 D 28985 CDS KLLA0_D09757g 2893250 complement(822299..824125) D 1 NC_006040.1 similar to uniprot|P47083 Saccharomyces cerevisiae YJR002W MPP10 Component of the SSU processome, which is required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p; rRNA-processing protein MPP10 824125 2893250 KLLA0_D09757g Kluyveromyces lactis rRNA-processing protein MPP10 XP_453497.1 822299 R 28985 CDS KLLA0_D09779g 2893175 complement(824518..826404) D 1 NC_006040.1 similar to uniprot|P47082 Saccharomyces cerevisiae YJR001W AVT1 Vacuolar transporter imports large neutral amino acids into the vacuole member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; uncharacterized protein 826404 2893175 KLLA0_D09779g Kluyveromyces lactis uncharacterized protein XP_453498.1 824518 R 28985 CDS KLLA0_D09801g 2893273 827563..830193 D 1 NC_006040.1 similar to uniprot|Q07895 Saccharomyces cerevisiae YLR001C Hypothetical ORF; uncharacterized protein 830193 2893273 KLLA0_D09801g Kluyveromyces lactis uncharacterized protein XP_453499.1 827563 D 28985 CDS KLLA0_D09867g 2893408 complement(831834..834218) D 1 NC_006040.1 similar to uniprot|P32567 Saccharomyces cerevisiae YMR165C SMP2 Protein involved in respiration and plasmid maintenance; phosphatidate phosphatase PAH1 834218 2893408 KLLA0_D09867g Kluyveromyces lactis phosphatidate phosphatase PAH1 XP_453500.1 831834 R 28985 CDS KLLA0_D09889g 2893319 complement(834904..835998) D 1 NC_006040.1 similar to uniprot|Q03829 Saccharomyces cerevisiae YMR166C Hypothetical ORF; uncharacterized protein 835998 2893319 KLLA0_D09889g Kluyveromyces lactis uncharacterized protein XP_453501.1 834904 R 28985 CDS KLLA0_D09911g 2893178 836851..838023 D 1 NC_006040.1 similar to uniprot|P43122 Saccharomyces cerevisiae YDL104C; uncharacterized protein 838023 2893178 KLLA0_D09911g Kluyveromyces lactis uncharacterized protein XP_453502.1 836851 D 28985 CDS KLLA0_D09933g 2892724 complement(838199..839356) D 1 NC_006040.1 similar to uniprot|P43124 Saccharomyces cerevisiae YDL105W NSE4 Nuclear protein that plays a role in the function of the Smc5p-Rhc18p complex; Smc5-Smc6 complex subunit NSE4 839356 2892724 KLLA0_D09933g Kluyveromyces lactis Smc5-Smc6 complex subunit NSE4 XP_453503.1 838199 R 28985 CDS KLLA0_D09955g 2892977 839640..841814 D 1 NC_006040.1 similar to uniprot|Q2I041 Saccharomyces cerevisiae YMR167W MLH1 Protein required for mismatch repair in mitosis and meiosis postmeiotic segregation and spore viability forms a complex with Pms1p and Msh2p to repair mismatched DNA human homolog is associated with hereditary non-polyposis colon cancer; mismatch repair ATPase MLH1 841814 2892977 KLLA0_D09955g Kluyveromyces lactis mismatch repair ATPase MLH1 XP_453504.1 839640 D 28985 CDS KLLA0_D09977g 2892846 complement(841852..843756) D 1 NC_006040.1 similar to uniprot|P40969 Saccharomyces cerevisiae YMR168C CEP3 Essential kinetochore protein component of the CBF3 complex that binds the CDEIII region of the centromere contains an N-terminal Zn2Cys6 type zinc finger domain a C-terminal acidic domain and a putative coiled coil dimerization domain; uncharacterized protein 843756 2892846 KLLA0_D09977g Kluyveromyces lactis uncharacterized protein XP_453505.1 841852 R 28985 CDS KLLA0_D09999g 2893159 complement(844368..845873) D 1 NC_006040.1 highly similar to uniprot|P47771 Saccharomyces cerevisiae YMR170C ALD2 Cytosolic aldehyde dehydrogenase that uses NAD as the preferred coenzyme expression is induced in response to high osmotic stress; uncharacterized protein 845873 2893159 KLLA0_D09999g Kluyveromyces lactis uncharacterized protein XP_453506.1 844368 R 28985 CDS KLLA0_D10021g 2893235 847239..848750 D 1 NC_006040.1 similar to uniprot|P47771 Saccharomyces cerevisiae YMR170c ALD5 and to uniprot|P54114 Saccharomyces cerevisiae YMR169c ALD4; uncharacterized protein 848750 2893235 KLLA0_D10021g Kluyveromyces lactis uncharacterized protein XP_453507.1 847239 D 28985 CDS KLLA0_D10043g 2893557 849549..851015 D 1 NC_006040.1 similar to uniprot|Q755L6 Ashbya gossypii AFL202C AFL202Cp and weakly similar to YDL106C uniprot|P07269 Saccharomyces cerevisiae YDL106C PHO2 Homeobox transcription factor regulatory targets include genes involved in phosphate metabolism binds cooperatively with Pho4p to the PHO5 promoter phosphorylation of Pho2p facilitates interaction with Pho4p; uncharacterized protein 851015 2893557 KLLA0_D10043g Kluyveromyces lactis uncharacterized protein XP_453508.1 849549 D 28985 CDS KLLA0_D10065g 2892717 complement(851283..852683) D 1 NC_006040.1 similar to uniprot|Q03212 Saccharomyces cerevisiae YMR171C Endosomal protein of unknown function mRNA is targeted to the bud via the mRNA transport system involving She2p; uncharacterized protein 852683 2892717 KLLA0_D10065g Kluyveromyces lactis uncharacterized protein XP_453509.1 851283 R 28985 CDS KLLA0_D10109g 2892741 854495..855424 D 1 NC_006040.1 similar to uniprot|P14065 Saccharomyces cerevisiae YOR120W GCY1 Putative NADP() coupled glycerol dehydrogenase proposed to be involved in an alternative pathway for glycerol catabolism; uncharacterized protein 855424 2892741 KLLA0_D10109g Kluyveromyces lactis uncharacterized protein XP_453511.1 854495 D 28985 CDS KLLA0_D10131g 2892920 complement(855951..857342) D 1 NC_006040.1 similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport; uncharacterized protein 857342 2892920 KLLA0_D10131g Kluyveromyces lactis uncharacterized protein XP_453512.1 855951 R 28985 CDS KLLA0_D10153g 2892981 858016..859983 D 1 NC_006040.1 some similarities with uniprot|P35995 Saccharomyces cerevisiae YKL222C Hypothetical ORF; uncharacterized protein 859983 2892981 KLLA0_D10153g Kluyveromyces lactis uncharacterized protein XP_453513.1 858016 D 28985 CDS KLLA0_D10175g 2893069 861073..861525 D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 861525 2893069 KLLA0_D10175g Kluyveromyces lactis uncharacterized protein XP_453514.1 861073 D 28985 CDS KLLA0_D10197g 2893577 complement(861726..864296) D 1 NC_006040.1 similar to uniprot|P05085 Saccharomyces cerevisiae YML099C ARG81 Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type involved in the regulation of arginine-responsive genes acts with Arg80p and Arg82p; uncharacterized protein 864296 2893577 KLLA0_D10197g Kluyveromyces lactis uncharacterized protein XP_453515.1 861726 R 28985 CDS KLLA0_D10219g 2893091 864863..865342 D 1 NC_006040.1 similar to uniprot|P11747 Saccharomyces cerevisiae YML098W; uncharacterized protein 865342 2893091 KLLA0_D10219g Kluyveromyces lactis uncharacterized protein XP_453516.1 864863 D 28985 CDS KLLA0_D10241g 2893596 complement(865680..867365) D 1 NC_006040.1 similar to uniprot|Q03103 Saccharomyces cerevisiae YML130C ERO1 Glycoprotein required for oxidative protein folding in the endoplasmic reticulum; ER oxidoreductin 867365 2893596 KLLA0_D10241g Kluyveromyces lactis ER oxidoreductin XP_453517.1 865680 R 28985 CDS KLLA0_D10263g 2893580 complement(868131..869444) D 1 NC_006040.1 similar to uniprot|P54787 Saccharomyces cerevisiae YML097C; guanine nucleotide exchange factor VPS9 869444 2893580 KLLA0_D10263g Kluyveromyces lactis guanine nucleotide exchange factor VPS9 XP_453518.1 868131 R 28985 CDS KLLA0_D10285g 2893161 869754..871301 D 1 NC_006040.1 similar to uniprot|Q04489 Saccharomyces cerevisiae YML096W Hypothetical ORF; uncharacterized protein 871301 2893161 KLLA0_D10285g Kluyveromyces lactis uncharacterized protein XP_453519.1 869754 D 28985 CDS KLLA0_D10307g 2893124 complement(871349..872050) D 1 NC_006040.1 similar to uniprot|P06838 Saccharomyces cerevisiae YML095C RAD10 Single-stranded DNA endonuclease (with Rad1p) cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair subunit of Nucleotide Excision Repair Factor 1 (NEF1) homolog of human XPF protein; DNA repair protein RAD10 872050 2893124 KLLA0_D10307g Kluyveromyces lactis DNA repair protein RAD10 XP_453520.1 871349 R 28985 CDS KLLA0_D10329g 2893233 join(872320..872335,872448..872896) D 1 NC_006040.1 highly similar to uniprot|Q04493 Saccharomyces cerevisiae YML094W GIM5 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it; uncharacterized protein 872896 2893233 KLLA0_D10329g Kluyveromyces lactis uncharacterized protein XP_453521.1 872320 D 28985 CDS KLLA0_D10351g 2893248 873366..875945 D 1 NC_006040.1 similar to uniprot|Q04500 Saccharomyces cerevisiae YML093W UTP14 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; uncharacterized protein 875945 2893248 KLLA0_D10351g Kluyveromyces lactis uncharacterized protein XP_453522.1 873366 D 28985 CDS KLLA0_D10373g 2893404 complement(876175..876927) D 1 NC_006040.1 highly similar to uniprot|P23639 Saccharomyces cerevisiae YML092C PRE8 20S proteasome beta-type subunit; proteasome core particle subunit alpha 2 876927 2893404 KLLA0_D10373g Kluyveromyces lactis proteasome core particle subunit alpha 2 XP_453523.1 876175 R 28985 CDS KLLA0_D10395g 2893458 join(877463..877468,877605..878282) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 878282 2893458 KLLA0_D10395g Kluyveromyces lactis uncharacterized protein XP_453524.2 877463 D 28985 CDS KLLA0_D10417g 2893587 complement(878575..878769) D 1 NC_006040.1 similar to uniprot|P39103 Saccharomyces cerevisiae YML129C COX14 Mitochondrial membrane protein, required for assembly of cytochrome c oxidase; uncharacterized protein 878769 2893587 KLLA0_D10417g Kluyveromyces lactis uncharacterized protein XP_453525.1 878575 R 28985 CDS KLLA0_D10439g 2892982 complement(879449..880906) D 1 NC_006040.1 similar to uniprot|Q03104 Saccharomyces cerevisiae YML128C MSC1 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum msc1 mutants are defective in directing meiotic recombination events to homologous chromatids; uncharacterized protein 880906 2892982 KLLA0_D10439g Kluyveromyces lactis uncharacterized protein XP_453526.1 879449 R 28985 CDS KLLA0_D10461g 2893052 882149..883843 D 1 NC_006040.1 similar to uniprot|Q03124 Saccharomyces cerevisiae YML127W RSC9 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway; uncharacterized protein 883843 2893052 KLLA0_D10461g Kluyveromyces lactis uncharacterized protein XP_453527.1 882149 D 28985 CDS KLLA0_D10483g 2892768 complement(884177..887839) D 1 NC_006040.1 similar to uniprot|Q02773 Saccharomyces cerevisiae YML091C RPM2 Protein component of mitochondrial RNase P along with the mitochondrially-encoded RNA subunit RPM1 Rnase P removes 5' extensions from tRNA precursors Rpm2p is also involved in maturation of RPM1 and in translation of mitochondrial mRNAs; ribonuclease P 887839 2892768 KLLA0_D10483g Kluyveromyces lactis ribonuclease P XP_453528.1 884177 R 28985 CDS KLLA0_D10505g 2893559 complement(join(889601..890893,891414..891515)) D 1 NC_006040.1 highly similar to uniprot|P54839 Saccharomyces cerevisiae YML126C ERG13 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis; hydroxymethylglutaryl-CoA synthase 891515 2893559 KLLA0_D10505g Kluyveromyces lactis hydroxymethylglutaryl-CoA synthase XP_453529.2 889601 R 28985 CDS KLLA0_D10527g 2893554 892955..894892 D 1 NC_006040.1 similar to uniprot|P23293 Saccharomyces cerevisiae YPR161C SGV1 CDC28/cdc2 related protein kinase; cyclin-dependent serine/threonine protein kinase SGV1 894892 2893554 KLLA0_D10527g Kluyveromyces lactis cyclin-dependent serine/threonine protein kinase SGV1 XP_453530.1 892955 D 28985 CDS KLLA0_D10549g 2893549 896011..898158 D 1 NC_006040.1 similar to uniprot|P11972 Saccharomyces cerevisiae YLR452C SST2 Protein involved in desensitization to alpha-factor pheromone member of the RGS (regulator of G-protein signalling) family GTPase-activating protein; GTPase-activating protein SST2 898158 2893549 KLLA0_D10549g Kluyveromyces lactis GTPase-activating protein SST2 XP_453531.1 896011 D 28985 CDS KLLA0_D10571g 2892809 complement(898296..899858) D 1 NC_006040.1 highly similar to uniprot|P32481 Saccharomyces cerevisiae YER025W GCD11 Gamma subunit of the translation initiation factor eIF2 involved in the identification of the start codon binds GTP when forming the ternary complex with GTP and tRNAi-Met; translation initiation factor eIF2 subunit gamma 899858 2892809 KLLA0_D10571g Kluyveromyces lactis translation initiation factor eIF2 subunit gamma XP_453532.1 898296 R 28985 CDS KLLA0_D10593g 2892795 complement(900326..903103) D 1 NC_006040.1 similar to uniprot|P08638 Saccharomyces cerevisiae YLR451W LEU3 Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation positively regulated by alpha-isopropylmalate an intermediate in leucine biosynthesis; leucine-responsive transcriptional regulator LEU3 903103 2892795 KLLA0_D10593g Kluyveromyces lactis leucine-responsive transcriptional regulator LEU3 XP_453533.1 900326 R 28985 CDS KLLA0_D10615g 2892729 903967..905322 D 1 NC_006040.1 similar to uniprot|P47159 Saccharomyces cerevisiae YJR124C Hypothetical ORF; uncharacterized protein 905322 2892729 KLLA0_D10615g Kluyveromyces lactis uncharacterized protein XP_453534.1 903967 D 28985 CDS KLLA0_D10637g 2893564 complement(905660..908257) D 1 NC_006040.1 similar to uniprot|P40017 YER024W Saccharomyces cerevisiae YAT2 Carnitine acetyltransferase; carnitine O-acetyltransferase YAT2 908257 2893564 KLLA0_D10637g Kluyveromyces lactis carnitine O-acetyltransferase YAT2 XP_453535.1 905660 R 28985 CDS KLLA0_D10659g 2892700 complement(909562..910245) D 1 NC_006040.1 highly similar to uniprot|P26783 Saccharomyces cerevisiae YJR123W; 40S ribosomal protein uS7 910245 2892700 KLLA0_D10659g Kluyveromyces lactis 40S ribosomal protein uS7 XP_453536.1 909562 R 28985 CDS KLLA0_D10681g 2892929 complement(911076..912464) D 1 NC_006040.1 similar to uniprot|P47158 Saccharomyces cerevisiae YJR122W CAF17 Mitochondrial protein that interacts with Ccr4p in the two-hybrid system 3'-untranslated region contains a putative mRNA localization element common to genes encoding mitochondrial proteins; uncharacterized protein 912464 2892929 KLLA0_D10681g Kluyveromyces lactis uncharacterized protein XP_453537.1 911076 R 28985 CDS KLLA0_D10703g 2893294 complement(913356..914873) D 1 NC_006040.1 highly similar to uniprot|P00830 Saccharomyces cerevisiae YJR121W ATP2 Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis; F1F0 ATP synthase subunit beta 914873 2893294 KLLA0_D10703g Kluyveromyces lactis F1F0 ATP synthase subunit beta XP_453538.1 913356 R 28985 CDS KLLA0_D10736g 2892904 complement(915650..916507) D 1 NC_006040.1 highly similar to uniprot|P32263 Saccharomyces cerevisiae YER023W PRO3 Delta 1-pyrroline-5-carboxylate reductase catalyzes the last step in proline biosynthesis; pyrroline-5-carboxylate reductase 916507 2892904 KLLA0_D10736g Kluyveromyces lactis pyrroline-5-carboxylate reductase XP_453540.1 915650 R 28985 CDS KLLA0_D10758g 2892974 917125..919677 D 1 NC_006040.1 similar to uniprot|P47156 Saccharomyces cerevisiae YJR119C Hypothetical ORF; histone demethylase 919677 2892974 KLLA0_D10758g Kluyveromyces lactis histone demethylase XP_453541.1 917125 D 28985 CDS KLLA0_D10780g 2892984 920068..920595 D 1 NC_006040.1 similar to uniprot|P47155 Saccharomyces cerevisiae YJR118C ILM1 Protein of unknown function; uncharacterized protein 920595 2892984 KLLA0_D10780g Kluyveromyces lactis uncharacterized protein XP_453542.1 920068 D 28985 CDS KLLA0_D10802g 2893583 complement(920627..922642) D 1 NC_006040.1 similar to uniprot|P32569 Saccharomyces cerevisiae YER022W SRB4 subunit of RNA polymerase II holoenzyme/mediator complex; uncharacterized protein 922642 2893583 KLLA0_D10802g Kluyveromyces lactis uncharacterized protein XP_453543.1 920627 R 28985 CDS KLLA0_D10824g 2893067 complement(922978..924498) D 1 NC_006040.1 similar to uniprot|P40016 Saccharomyces cerevisiae YER021W; proteasome regulatory particle lid subunit RPN3 924498 2893067 KLLA0_D10824g Kluyveromyces lactis proteasome regulatory particle lid subunit RPN3 XP_453544.1 922978 R 28985 CDS KLLA0_D10846g 2893119 complement(925012..926382) D 1 NC_006040.1 highly similar to uniprot|P47154 Saccharomyces cerevisiae YJR117W STE24 Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing contains multiple transmembrane spans; zinc metalloprotease 926382 2893119 KLLA0_D10846g Kluyveromyces lactis zinc metalloprotease XP_453545.1 925012 R 28985 CDS KLLA0_D10868g 2893171 complement(926978..927829) D 1 NC_006040.1 similar to uniprot|P47153 Saccharomyces cerevisiae YJR116W Hypothetical ORF; uncharacterized protein 927829 2893171 KLLA0_D10868g Kluyveromyces lactis uncharacterized protein XP_453546.1 926978 R 28985 CDS KLLA0_D10890g 2893214 928435..929733 D 1 NC_006040.1 similar to uniprot|P47143 Saccharomyces cerevisiae YJR105W ADO1 adenosine kinase; adenosine kinase 929733 2893214 KLLA0_D10890g Kluyveromyces lactis adenosine kinase XP_453547.1 928435 D 28985 CDS KLLA0_D10912g 2893461 930173..932089 D 1 NC_006040.1 similar to uniprot|Q75D63 Ashbya gossypii ABR160C ABR160Cp and weakly similar to YJR106W uniprot|P47144 Saccharomyces cerevisiae YJR106W ECM27 Non-essential protein of unknown function; uncharacterized protein 932089 2893461 KLLA0_D10912g Kluyveromyces lactis uncharacterized protein XP_453548.1 930173 D 28985 CDS KLLA0_D10934g 2893393 932344..933474 D 1 NC_006040.1 similar to uniprot|P47145 Saccharomyces cerevisiae YJR107W Hypothetical ORF; uncharacterized protein 933474 2893393 KLLA0_D10934g Kluyveromyces lactis uncharacterized protein XP_453549.1 932344 D 28985 CDS KLLA0_D10956g 2893290 complement(934074..935738) D 1 NC_006040.1 uniprot|P54111 Kluyveromyces lactis GPA2 Guanine nucleotide-binding protein alpha-2 subunit; guanine nucleotide-binding protein subunit alpha 935738 2893290 KLLA0_D10956g Kluyveromyces lactis guanine nucleotide-binding protein subunit alpha XP_453550.1 934074 R 28985 CDS KLLA0_D10978g 2893047 936863..937675 D 1 NC_006040.1 similar to uniprot|P53899 Saccharomyces cerevisiae YNL155W Hypothetical ORF; uncharacterized protein 937675 2893047 KLLA0_D10978g Kluyveromyces lactis uncharacterized protein XP_453551.1 936863 D 28985 CDS KLLA0_D11000g 2892949 938541..939620 D 1 NC_006040.1 similar to uniprot|P53183 Saccharomyces cerevisiae YGL039W and similar to uniprot|P53111 Saccharomyces cerevisiae YGL157W and similar to uniprot|Q12068 Saccharomyces cerevisiae YOL151W and similar to uniprot|Q03049 Saccharomyces cerevisiae YDR541C NADPH-dependent Oxidoreductases; uncharacterized protein 939620 2892949 KLLA0_D11000g Kluyveromyces lactis uncharacterized protein XP_453552.1 938541 D 28985 CDS KLLA0_D11022g 2893315 940600..941679 D 1 NC_006040.1 similar to uniprot|P53183 Saccharomyces cerevisiae YGL039W and similar to uniprot|P53111 Saccharomyces cerevisiae YGL157W and similar to uniprot|Q12068 Saccharomyces cerevisiae YOL151W and similar to uniprot|Q03049 Saccharomyces cerevisiae YDR541C NADPH-dependent Oxidoreductases; uncharacterized protein 941679 2893315 KLLA0_D11022g Kluyveromyces lactis uncharacterized protein XP_453553.1 940600 D 28985 CDS KLLA0_D11044g 2892738 complement(942458..944068) D 1 NC_006040.1 some similarities with uniprot|P23292 Saccharomyces cerevisiae YNL154C YCK2 membrane-bound casein kinase I homolog; uncharacterized protein 944068 2892738 KLLA0_D11044g Kluyveromyces lactis uncharacterized protein XP_453554.1 942458 R 28985 CDS KLLA0_D11066g 2892903 complement(945075..945875) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 945875 2892903 KLLA0_D11066g Kluyveromyces lactis uncharacterized protein XP_453555.1 945075 R 28985 CDS KLLA0_D11088g 2892898 947523..947894 D 1 NC_006040.1 no similarity; uncharacterized protein 947894 2892898 KLLA0_D11088g Kluyveromyces lactis uncharacterized protein XP_453556.1 947523 D 28985 CDS KLLA0_D11110g 2892967 948248..949840 D 1 NC_006040.1 similar to uniprot|P38840 Saccharomyces cerevisiae YHR137W ARO9 Aromatic aminotransferase catalyzes the first step of tryptophan phenylalanine and tyrosine catabolism; aromatic-amino-acid:2-oxoglutarate transaminase 949840 2892967 KLLA0_D11110g Kluyveromyces lactis aromatic-amino-acid:2-oxoglutarate transaminase XP_453557.1 948248 D 28985 CDS KLLA0_D11132g 2893099 950190..950579 D 1 NC_006040.1 highly similar to uniprot|P53900 Saccharomyces cerevisiae YNL153C GIM3 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it; tubulin-binding prefolding complex subunit GIM3 950579 2893099 KLLA0_D11132g Kluyveromyces lactis tubulin-binding prefolding complex subunit GIM3 XP_453558.1 950190 D 28985 CDS KLLA0_D11143g 9487521 complement(join(950719..950963,951052..951097)) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 951097 9487521 KLLA0_D11143g Kluyveromyces lactis uncharacterized protein XP_002999372.1 950719 R 28985 CDS KLLA0_D11154g 2893576 952049..953530 D 1 NC_006040.1 highly similar to uniprot|P09624 Saccharomyces cerevisiae YFL018C LPD1 Dihydrolipoamide dehydrogenase the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes; dihydrolipoyl dehydrogenase 953530 2893576 KLLA0_D11154g Kluyveromyces lactis dihydrolipoyl dehydrogenase XP_453559.1 952049 D 28985 CDS KLLA0_D11198g 2893152 complement(954239..955786) D 1 NC_006040.1 similar to uniprot|Q75DH5 Ashbya gossypii ABR051C ABR051Cp and weakly similar to YMR013C uniprot|P20048 Saccharomyces cerevisiae YMR013C SEC59 Membrane protein that catalyzes the CTP-mediated phosphorylation of dolichol the terminal step in dolichyl monophosphate (Dol- P) biosynthesis required for viability normal rates of lipid intermediate synthesis and protein N-glycosylation; dolichol kinase 955786 2893152 KLLA0_D11198g Kluyveromyces lactis dolichol kinase XP_453560.1 954239 R 28985 CDS KLLA0_D11220g 2893134 958249..959682 D 1 NC_006040.1 similar to gnl|GLV|CAGL0M07678g Candida glabrata CAGL0M07678g and weakly similar to YMR014W uniprot|Q04347 Saccharomyces cerevisiae YMR014W BUD22 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; uncharacterized protein 959682 2893134 KLLA0_D11220g Kluyveromyces lactis uncharacterized protein XP_453561.1 958249 D 28985 CDS KLLA0_D11242g 2893180 complement(959973..961577) D 1 NC_006040.1 highly similar to uniprot|P54781 Saccharomyces cerevisiae YMR015C ERG5 C-22 sterol desaturase a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis may be a target of azole antifungal drugs; C-22 sterol desaturase 961577 2893180 KLLA0_D11242g Kluyveromyces lactis C-22 sterol desaturase XP_453562.1 959973 R 28985 CDS KLLA0_D11264g 2893219 complement(962069..964108) D 1 NC_006040.1 some similarities with uniprot|Q03213 Saccharomyces cerevisiae YMR172W; uncharacterized protein 964108 2893219 KLLA0_D11264g Kluyveromyces lactis uncharacterized protein XP_453563.1 962069 R 28985 CDS KLLA0_D11286g 2893228 complement(964642..966678) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 966678 2893228 KLLA0_D11286g Kluyveromyces lactis uncharacterized protein XP_453564.1 964642 R 28985 CDS KLLA0_D11308g 2893265 complement(967169..968806) D 1 NC_006040.1 similar to uniprot|O94493 Schizosaccharomyces pombe SPCC417 SPCC417.12 protein; uncharacterized protein 968806 2893265 KLLA0_D11308g Kluyveromyces lactis uncharacterized protein XP_453565.1 967169 R 28985 CDS KLLA0_D11330g 2893231 970243..971808 D 1 NC_006040.1 similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoin permease ureidosuccinate permease expression is constitutive but sensitive to nitrogen catabolite repression; uncharacterized protein 971808 2893231 KLLA0_D11330g Kluyveromyces lactis uncharacterized protein XP_453566.1 970243 D 28985 CDS KLLA0_D11352g 2893280 973371..974828 D 1 NC_006040.1 highly similar to uniprot|P04807 Saccharomyces cerevisiae YGL253W HXK2 Hexokinase isoenzyme 2 catalyzes phosphorylation of glucose in the cytosol predominate hexokinase during growth on glucose functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; uncharacterized protein 974828 2893280 KLLA0_D11352g Kluyveromyces lactis uncharacterized protein XP_453567.1 973371 D 28985 CDS KLLA0_D11374g 2893275 complement(975206..976003) D 1 NC_006040.1 similar to uniprot|P32496 Saccharomyces cerevisiae YFR052W RPN12 Subunit of the 19S regulatory particle of the 26S proteasome lid synthetically lethal with RPT1 which is an ATPase component of the 19S regulatory particle physically interacts with Nob1p and Rpn3p; proteasome regulatory particle lid subunit RPN12 976003 2893275 KLLA0_D11374g Kluyveromyces lactis proteasome regulatory particle lid subunit RPN12 XP_453568.1 975206 R 28985 CDS KLLA0_D11396g 2893503 complement(976408..978018) D 1 NC_006040.1 similar to uniprot|P43621 Saccharomyces cerevisiae YFR051C RET2 Delta subunit of the coatomer complex (COPI) which coats Golgi-derived transport vesicles involved in retrograde transport between Golgi and ER; coatomer subunit delta 978018 2893503 KLLA0_D11396g Kluyveromyces lactis coatomer subunit delta XP_453569.1 976408 R 28985 CDS KLLA0_D11418g 2893561 complement(978322..980349) D 1 NC_006040.1 weakly similar to uniprot|P53061 Saccharomyces cerevisiae YGL249W ZIP2 Required for 'ZIPpering' up meiotic chromosomes during chromosome synapsis involved in meiotic recombination and disjunction; uncharacterized protein 980349 2893561 KLLA0_D11418g Kluyveromyces lactis uncharacterized protein XP_453570.1 978322 R 28985 CDS KLLA0_D11440g 2892850 complement(980535..981428) D 1 NC_006040.1 similar to uniprot|P53060 Saccharomyces cerevisiae YGL250W Hypothetical ORF; uncharacterized protein 981428 2892850 KLLA0_D11440g Kluyveromyces lactis uncharacterized protein XP_453571.1 980535 R 28985 CDS KLLA0_D11462g 2893420 982040..985303 D 1 NC_006040.1 similar to uniprot|P51979 Saccharomyces cerevisiae YGL251C HFM1 Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control catalyzes the unwinding of Holliday junctions has ssDNA and dsDNA stimulated ATPase activity; DNA helicase 985303 2893420 KLLA0_D11462g Kluyveromyces lactis DNA helicase XP_453572.1 982040 D 28985 CDS KLLA0_D11484g 2893456 985655..987418 D 1 NC_006040.1 highly similar to uniprot|P32608 Saccharomyces cerevisiae YGL252C RTG2 Sensor of mitochondrial dysfunction regulates the subcellular location of Rtg1p and Rtg3p transcriptional activators of the retrograde (RTG) and TOR pathways Rtg2p is inhibited by the phosphorylated form of Mks1p; uncharacterized protein 987418 2893456 KLLA0_D11484g Kluyveromyces lactis uncharacterized protein XP_453573.1 985655 D 28985 CDS KLLA0_D11506g 2892765 987844..988641 D 1 NC_006040.1 highly similar to uniprot|P30657 Saccharomyces cerevisiae YFR050C PRE4 20S proteasome beta-type subunit; proteasome core particle subunit beta 7 988641 2892765 KLLA0_D11506g Kluyveromyces lactis proteasome core particle subunit beta 7 XP_453574.1 987844 D 28985 CDS KLLA0_D11528g 2893547 989252..990358 D 1 NC_006040.1 similar to uniprot|P22434 Saccharomyces cerevisiae YGL248W PDE1 Low-affinity cyclic AMP phosphodiesterase controls glucose and intracellular acidification-induced cAMP signaling target of the cAMP-protein kinase A (PKA) pathway glucose induces transcription and inhibits translation; 3',5'-cyclic-nucleotide phosphodiesterase PDE1 990358 2893547 KLLA0_D11528g Kluyveromyces lactis 3',5'-cyclic-nucleotide phosphodiesterase PDE1 XP_453575.1 989252 D 28985 CDS KLLA0_D11550g 2892877 complement(990698..991099) D 1 NC_006040.1 similar to uniprot|P19955 Saccharomyces cerevisiae YFR049W YMR31 Mitochondrial ribosomal protein of the small subunit; alpha-ketoglutarate dehydrogenase subunit KGD4 991099 2892877 KLLA0_D11550g Kluyveromyces lactis alpha-ketoglutarate dehydrogenase subunit KGD4 XP_453576.1 990698 R 28985 CDS KLLA0_D11572g 2893236 complement(991747..992865) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 992865 2893236 KLLA0_D11572g Kluyveromyces lactis uncharacterized protein XP_453577.1 991747 R 28985 CDS KLLA0_D11594g 2893534 993485..994144 D 1 NC_006040.1 similar to uniprot|P29547 Saccharomyces cerevisiae YPL048W CAM1 Translational cofactor elongation factor-1 gamma participates in the regulation of GTP-binding protein EF-1 alpha may play a redundant role in the regulation of protein synthesis or another GTP-dependent process; translation elongation factor EF1B gamma 994144 2893534 KLLA0_D11594g Kluyveromyces lactis translation elongation factor EF1B gamma XP_453578.1 993485 D 28985 CDS KLLA0_D11638g 2892778 995087..996262 D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 996262 2892778 KLLA0_D11638g Kluyveromyces lactis uncharacterized protein XP_453580.1 995087 D 28985 CDS KLLA0_D11660g 2893117 996785..998320 D 1 NC_006040.1 highly similar to uniprot|P15202 Saccharomyces cerevisiae YDR256C CTA1 Catalase A breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation; catalase A 998320 2893117 KLLA0_D11660g Kluyveromyces lactis catalase A XP_453581.1 996785 D 28985 CDS KLLA0_D11682g 2893004 998670..998963 D 1 NC_006040.1 similar to uniprot|Q03067 Saccharomyces cerevisiae YPL047W SGF11 11kDa subunit of the SAGA histone acetyltransferase complex involved in regulation of transcription of a subset of SAGA-regulated genes; SAGA histone acetyltransferase complex subunit SGF11 998963 2893004 KLLA0_D11682g Kluyveromyces lactis SAGA histone acetyltransferase complex subunit SGF11 XP_453582.1 998670 D 28985 CDS KLLA0_D11704g 2893589 999198..1000388 D 1 NC_006040.1 similar to uniprot|Q12508 Saccharomyces cerevisiae YDR255C RMD5 Cytosolic protein required for sporulation also required for the ubiquitination of the gluconeogenetic enzyme fructose-1 6-bisphosphatase which is degraded rapidly after the switch from gluconeogenesis to glycolysis; ubiquitin-protein ligase RMD5 1000388 2893589 KLLA0_D11704g Kluyveromyces lactis ubiquitin-protein ligase RMD5 XP_453583.1 999198 D 28985 CDS KLLA0_D11726g 2893279 complement(1000442..1000732) D 1 NC_006040.1 similar to uniprot|O13292 Saccharomyces cerevisiae YPL046C ELC1 Elongin C forms heterodimer with Ela1p that participates in transcription elongation expression dramatically upregulated during sporulation widely conserved among eukaryotes; elongin C 1000732 2893279 KLLA0_D11726g Kluyveromyces lactis elongin C XP_453584.1 1000442 R 28985 CDS KLLA0_D11748g 2893232 1000988..1003369 D 1 NC_006040.1 similar to uniprot|Q03308 Saccharomyces cerevisiae YPL045W VPS16 Vacuolar sorting protein; tethering complex subunit VPS16 1003369 2893232 KLLA0_D11748g Kluyveromyces lactis tethering complex subunit VPS16 XP_453585.1 1000988 D 28985 CDS KLLA0_D11770g 2892980 complement(1003388..1004617) D 1 NC_006040.1 weakly similar to uniprot|P38907 Saccharomyces cerevisiae YDR254W CHL4 Outer kinetochore protein; uncharacterized protein 1004617 2892980 KLLA0_D11770g Kluyveromyces lactis uncharacterized protein XP_453586.1 1003388 R 28985 CDS KLLA0_D11792g 2893068 1005079..1007136 D 1 NC_006040.1 similar to uniprot|P37838 Saccharomyces cerevisiae YPL043W NOP4 Nucleolar protein essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis contains four RNA recognition motifs (RRMs); mRNA-binding ribosome biosynthesis protein NOP4 1007136 2893068 KLLA0_D11792g Kluyveromyces lactis mRNA-binding ribosome biosynthesis protein NOP4 XP_453587.1 1005079 D 28985 CDS KLLA0_D11814g 2892704 complement(1007240..1009021) D 1 NC_006040.1 uniprot|Q70W23 Kluyveromyces lactis srb10 Cyclin-dependent protein kinase; cyclin-dependent serine/threonine protein kinase SSN3 1009021 2892704 KLLA0_D11814g Kluyveromyces lactis cyclin-dependent serine/threonine protein kinase SSN3 XP_453588.1 1007240 R 28985 CDS KLLA0_D11836g 2892928 complement(1009428..1010030) D 1 NC_006040.1 some similarities with uniprot|Q6LE92 Saccharomyces cerevisiae YPL041C Hypothetical ORF; uncharacterized protein 1010030 2892928 KLLA0_D11836g Kluyveromyces lactis uncharacterized protein XP_453589.1 1009428 R 28985 CDS KLLA0_D11858g 2892914 complement(1010259..1013231) D 1 NC_006040.1 similar to uniprot|P48526 Saccharomyces cerevisiae YPL040C ISM1 Mitochondrial isoleucyl-tRNA synthetase null mutant is deficient in respiratory growth; isoleucine--tRNA ligase ISM1 1013231 2892914 KLLA0_D11858g Kluyveromyces lactis isoleucine--tRNA ligase ISM1 XP_453590.1 1010259 R 28985 CDS KLLA0_D11880g 2892941 1013755..1014711 D 1 NC_006040.1 some similarities with uniprot|Q03080 Saccharomyces cerevisiae YPL039W Hypothetical ORF; uncharacterized protein 1014711 2892941 KLLA0_D11880g Kluyveromyces lactis uncharacterized protein XP_453591.1 1013755 D 28985 CDS KLLA0_D11902g 2892770 1015273..1016142 D 1 NC_006040.1 some similarities with uniprot|Q12041 Saccharomyces cerevisiae YDR253C MET32 and some similarities with uniprot|Q03081 Saccharomyces cerevisiae YPL038W MET31 Zinc-finger DNA-binding proteins; uncharacterized protein 1016142 2892770 KLLA0_D11902g Kluyveromyces lactis uncharacterized protein XP_453592.1 1015273 D 28985 CDS KLLA0_D11924g 2893166 complement(1016451..1016927) D 1 NC_006040.1 similar to uniprot|Q02642 Saccharomyces cerevisiae YPL037C EGD1 Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting associated with cytoplasmic ribosomes enhances DNA binding of the Gal4p activator homolog of human BTF3b; uncharacterized protein 1016927 2893166 KLLA0_D11924g Kluyveromyces lactis uncharacterized protein XP_453593.1 1016451 R 28985 CDS KLLA0_D11946g 2893147 complement(1017503..1020235) D 1 NC_006040.1 some similarities with Saccharomyces cerevisiae YPL032C SVL3 Protein of unknown function mutant phenotype suggests a potential role in vacuolar function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm bud and bud neck and with YDR251W uniprot|P37304 Saccharomyces cerevisiae YDR251W PAM1 Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype; uncharacterized protein 1020235 2893147 KLLA0_D11946g Kluyveromyces lactis uncharacterized protein XP_453594.1 1017503 R 28985 CDS KLLA0_D11968g 2893162 1021670..1022782 D 1 NC_006040.1 weakly similar to uniprot|Q03787 Saccharomyces cerevisiae YDR249C Hypothetical ORF; uncharacterized protein 1022782 2893162 KLLA0_D11968g Kluyveromyces lactis uncharacterized protein XP_453595.1 1021670 D 28985 CDS KLLA0_D11990g 2893430 complement(join(1022895..1023792,1023928..1023944)) D 1 NC_006040.1 highly similar to uniprot|P17157 Saccharomyces cerevisiae YPL031C PHO85 Cyclin-dependent kinase with ten cyclin partners involved in environmental stress response in phosphate-rich conditions Pho85p-Pho80p complex phosphorylates Pho4p which in turn represses PHO5; cyclin-dependent serine/threonine-protein kinase PHO85 1023944 2893430 KLLA0_D11990g Kluyveromyces lactis cyclin-dependent serine/threonine-protein kinase PHO85 XP_453596.1 1022895 R 28985 CDS KLLA0_D12012g 2893502 1024590..1026203 D 1 NC_006040.1 similar to uniprot|Q2XN15 Saccharomyces cerevisiae YPL030W Hypothetical ORF; tRNA (uracil) methyltransferase 1026203 2893502 KLLA0_D12012g Kluyveromyces lactis tRNA (uracil) methyltransferase XP_453597.1 1024590 D 28985 CDS KLLA0_D12034g 2893528 1026586..1028841 D 1 NC_006040.1 similar to uniprot|P32580 Saccharomyces cerevisiae YPL029W SUV3 ATP-dependent RNA helicase component of the mitochondrial degradosome; ATP-dependent RNA helicase SUV3 1028841 2893528 KLLA0_D12034g Kluyveromyces lactis ATP-dependent RNA helicase SUV3 XP_453598.1 1026586 D 28985 CDS KLLA0_D12056g 2893283 1029222..1030418 D 1 NC_006040.1 highly similar to uniprot|P41338 Saccharomyces cerevisiae YPL028W ERG10 Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another forming acetoacetyl-CoA involved in the first step in mevalonate biosynthesis; acetyl-CoA C-acetyltransferase 1030418 2893283 KLLA0_D12056g Kluyveromyces lactis acetyl-CoA C-acetyltransferase XP_453599.1 1029222 D 28985 CDS KLLA0_D12078g 2893284 1030847..1031392 D 1 NC_006040.1 similar to uniprot|Q03786 Saccharomyces cerevisiae YDR248C Hypothetical ORF; gluconokinase 1031392 2893284 KLLA0_D12078g Kluyveromyces lactis gluconokinase XP_453600.1 1030847 D 28985 CDS KLLA0_D12100g 2893508 complement(1031728..1033161) D 1 NC_006040.1 similar to uniprot|Q12505 Saccharomyces cerevisiae YPL026C SKS1 multicopy suppressor of snf3 and grr1 mutants serine/threonine protein kinase homologous to Ran1p; uncharacterized protein 1033161 2893508 KLLA0_D12100g Kluyveromyces lactis uncharacterized protein XP_453601.1 1031728 R 28985 CDS KLLA0_D12122g 2893285 complement(1033231..1033581) D 1 NC_006040.1 no similarity; uncharacterized protein 1033581 2893285 KLLA0_D12122g Kluyveromyces lactis uncharacterized protein XP_453602.1 1033231 R 28985 CDS KLLA0_D12144g 2893182 complement(1034038..1034610) D 1 NC_006040.1 similar to uniprot|Q03784 Saccharomyces cerevisiae YDR246W TRS23 Component of the targeting complex (TRAPP) involved in ER to Golgi membrane traffic; TRAPP subunit TRS23 1034610 2893182 KLLA0_D12144g Kluyveromyces lactis TRAPP subunit TRS23 XP_453603.1 1034038 R 28985 CDS KLLA0_D12166g 2893184 1034883..1035578 D 1 NC_006040.1 similar to uniprot|Q02685 Saccharomyces cerevisiae YPL024W RMI1 Protein of unknown function GFP tagged protein localizes to the cytoplasm and nucleus; uncharacterized protein 1035578 2893184 KLLA0_D12166g Kluyveromyces lactis uncharacterized protein XP_453604.1 1034883 D 28985 CDS KLLA0_D12188g 2892994 complement(1035588..1037537) D 1 NC_006040.1 similar to uniprot|P46151 Saccharomyces cerevisiae YPL023C MET12 Isozyme of methylenetetrahydrofolate reductase catalyzes the reduction of 5 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway; methylenetetrahydrofolate reductase (NAD(P)H) MET12 1037537 2892994 KLLA0_D12188g Kluyveromyces lactis methylenetetrahydrofolate reductase (NAD(P)H) MET12 XP_453605.1 1035588 R 28985 CDS KLLA0_D12210g 2892986 1037870..1041040 D 1 NC_006040.1 similar to uniprot|P06777 Saccharomyces cerevisiae YPL022W RAD1 Single-stranded DNA endonuclease; ssDNA endodeoxyribonuclease RAD1 1041040 2892986 KLLA0_D12210g Kluyveromyces lactis ssDNA endodeoxyribonuclease RAD1 XP_453606.1 1037870 D 28985 CDS KLLA0_D12232g 2893195 complement(1041135..1044527) D 1 NC_006040.1 some similarities with uniprot|P09547 Saccharomyces cerevisiae YPL016W SWI1 Global transcription activator that acts in complex with Snf2p Snf5p Snf6p and Swi3p to assist gene-specific activators involved in the regulation of expression of many genes including ADH1 ADH2 GAL1 HO INO1 and SUC2 Zinc-finger transcription factor; uncharacterized protein 1044527 2893195 KLLA0_D12232g Kluyveromyces lactis uncharacterized protein XP_453607.1 1041135 R 28985 CDS KLLA0_D12254g 2893196 1045077..1046618 D 1 NC_006040.1 highly similar to uniprot|Q12460 Saccharomyces cerevisiae YLR197W SIK1 Component of the small (ribosomal) subunit (SSU) processosome that contains U3 snoRNA; snoRNP complex protein NOP56 1046618 2893196 KLLA0_D12254g Kluyveromyces lactis snoRNP complex protein NOP56 XP_453608.1 1045077 D 28985 CDS KLLA0_D12276g 2893309 complement(join(1046970..1047737,1047816..1047824)) D 1 NC_006040.1 similar to uniprot|Q05778 Saccharomyces cerevisiae YLR199C Hypothetical ORF; uncharacterized protein 1047824 2893309 KLLA0_D12276g Kluyveromyces lactis uncharacterized protein XP_453609.2 1046970 R 28985 CDS KLLA0_D12298g 2893310 1048089..1048436 D 1 NC_006040.1 similar to uniprot|P52553 Saccharomyces cerevisiae YLR200W YKE2 Yeast nuclear gene; tubulin-binding prefolding complex subunit YKE2 1048436 2893310 KLLA0_D12298g Kluyveromyces lactis tubulin-binding prefolding complex subunit YKE2 XP_453610.1 1048089 D 28985 CDS KLLA0_D12320g 2893155 complement(1048556..1049308) D 1 NC_006040.1 similar to uniprot|Q05779 Saccharomyces cerevisiae YLR201C FMP53; ubiquinone biosynthesis protein COQ9 1049308 2893155 KLLA0_D12320g Kluyveromyces lactis ubiquinone biosynthesis protein COQ9 XP_453611.1 1048556 R 28985 CDS KLLA0_D12342g 2892855 1050181..1051335 D 1 NC_006040.1 highly similar to uniprot|P32771 Saccharomyces cerevisiae YDL168W SFA1 Long-chain alcohol dehydrogenase (glutathione-dependent formaldehyde dehydrogenase); bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase 1051335 2892855 KLLA0_D12342g Kluyveromyces lactis bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase XP_453612.1 1050181 D 28985 CDS KLLA0_D12364g 2893545 complement(1051765..1053660) D 1 NC_006040.1 some similarities with uniprot|P32770 Saccharomyces cerevisiae YDL167C NRP1; uncharacterized protein 1053660 2893545 KLLA0_D12364g Kluyveromyces lactis uncharacterized protein XP_453613.1 1051765 R 28985 CDS KLLA0_D12386g 2892761 complement(1054141..1054776) D 1 NC_006040.1 similar to uniprot|Q12055 Saccharomyces cerevisiae YDL166C FAP7 Essential nuclear protein involved in the oxidative stress response; nucleoside-triphosphatase 1054776 2892761 KLLA0_D12386g Kluyveromyces lactis nucleoside-triphosphatase XP_453614.1 1054141 R 28985 CDS KLLA0_D12408g 2892847 1055117..1055671 D 1 NC_006040.1 similar to uniprot|P06100 Saccharomyces cerevisiae YDL165W CDC36 Component of the CCR4-NOT complex which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation basal transcription factor; CCR4-NOT core subunit CDC36 1055671 2892847 KLLA0_D12408g Kluyveromyces lactis CCR4-NOT core subunit CDC36 XP_453615.1 1055117 D 28985 CDS KLLA0_D12430g 2892885 complement(1055878..1057134) D 1 NC_006040.1 similar to uniprot|P32335 Saccharomyces cerevisiae YLR203C MSS51 Protein required for the maturation and translation of COX1 mRNA involved in maturation of COX1 and COB mRNA; uncharacterized protein 1057134 2892885 KLLA0_D12430g Kluyveromyces lactis uncharacterized protein XP_453616.1 1055878 R 28985 CDS KLLA0_D12452g 2892845 1057600..1057944 D 1 NC_006040.1 some similarities with uniprot|P32344 Saccharomyces cerevisiae YLR204W QRI5; uncharacterized protein 1057944 2892845 KLLA0_D12452g Kluyveromyces lactis uncharacterized protein XP_453617.1 1057600 D 28985 CDS KLLA0_D12474g 2892838 complement(1058158..1059096) D 1 NC_006040.1 similar to uniprot|P32339 Saccharomyces cerevisiae YLR205C HMX1 ER localized, heme-binding peroxidase involved in the degradation of heme; uncharacterized protein 1059096 2892838 KLLA0_D12474g Kluyveromyces lactis uncharacterized protein XP_453618.1 1058158 R 28985 CDS KLLA0_D12496g 2892839 complement(1059684..1061786) D 1 NC_006040.1 similar to uniprot|P04819 Saccharomyces cerevisiae YDL164C CDC9 DNA ligase found in the nucleus and mitochondria an essential enzyme that joins Okazaki fragments during DNA replication also acts in nucleotide excision repair base excision repair and recombination; DNA ligase (ATP) CDC9 1061786 2892839 KLLA0_D12496g Kluyveromyces lactis DNA ligase (ATP) CDC9 XP_453619.1 1059684 R 28985 CDS KLLA0_D12518g 2893568 complement(1062521..1063192) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 1063192 2893568 KLLA0_D12518g Kluyveromyces lactis uncharacterized protein XP_453620.1 1062521 R 28985 CDS KLLA0_D12540g 2893002 complement(join(1063576..1063862,1064278..1064293)) D 1 NC_006040.1 highly similar to uniprot|P05745 Saccharomyces cerevisiae YMR194W RPL36A and to uniprot|O14455 Saccharomyces cerevisiae YPL249C-A RPL36B Proteins component of the large (60S) ribosomal subunit; 60S ribosomal protein eL36 1064293 2893002 KLLA0_D12540g Kluyveromyces lactis 60S ribosomal protein eL36 XP_453621.1 1063576 R 28985 CDS KLLA0_D12562g 2892947 complement(1064961..1065728) D 1 NC_006040.1 highly similar to uniprot|P36525 Saccharomyces cerevisiae YMR193W MRPL24 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein bL28m 1065728 2892947 KLLA0_D12562g Kluyveromyces lactis mitochondrial 54S ribosomal protein bL28m XP_453622.1 1064961 R 28985 CDS KLLA0_D12584g 2892951 complement(1066032..1068155) D 1 NC_006040.1 some similarities with uniprot|Q12344 Saccharomyces cerevisiae YPL249C GYP5 GTPase-activating protein (GAP) for yeast Rab family members Ypt1p is the preferred in vitro substrate but also acts on Sec4p involved in ER to Golgi trafficking interacts with the yeast amphiphysins Rvs161p and Rvs167p; uncharacterized protein 1068155 2892951 KLLA0_D12584g Kluyveromyces lactis uncharacterized protein XP_453623.1 1066032 R 28985 CDS KLLA0_D12606g 2892932 complement(1068516..1070297) D 1 NC_006040.1 weakly similar to uniprot|P53389 Saccharomyces cerevisiae YNR055C HOL1 Putative ion transporter similar to the major facilitator superfamily of transporters; mutations in membrane-spanning domains permit nonselective cation uptake; uncharacterized protein 1070297 2892932 KLLA0_D12606g Kluyveromyces lactis uncharacterized protein XP_453624.1 1068516 R 28985 CDS KLLA0_D12628g 2893371 1071637..1073373 D 1 NC_006040.1 weakly similar to uniprot|P22580 Saccharomyces cerevisiae YDR242W AMD2 Putative amidase; uncharacterized protein 1073373 2893371 KLLA0_D12628g Kluyveromyces lactis uncharacterized protein XP_453625.1 1071637 D 28985 CDS KLLA0_D12650g 2893370 complement(1073580..1075535) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 1075535 2893370 KLLA0_D12650g Kluyveromyces lactis uncharacterized protein XP_453626.1 1073580 R 28985 CDS KLLA0_D12672g 2893282 complement(1076011..1078608) D 1 NC_006040.1 uniprot|P08657 Kluyveromyces lactis LAC9 Lactose regulatory protein LAC9; galactose-responsive transcription factor GAL4 1078608 2893282 KLLA0_D12672g Kluyveromyces lactis galactose-responsive transcription factor GAL4 XP_453627.1 1076011 R 28985 CDS KLLA0_D12694g 2893372 1079740..1083843 D 1 NC_006040.1 similar to uniprot|P35187 Saccharomyces cerevisiae YMR190C SGS1 Nucleolar DNA helicase of the RecQ family, involved in maintenance of genome integrity; ATP-dependent DNA helicase SGS1 1083843 2893372 KLLA0_D12694g Kluyveromyces lactis ATP-dependent DNA helicase SGS1 XP_453628.1 1079740 D 28985 CDS KLLA0_D12716g 2893373 complement(1084062..1085849) D 1 NC_006040.1 similar to uniprot|P39709 Saccharomyces cerevisiae YAL067C SEO1 Putative permease member of the allantoate transporter subfamily of the major facilitator superfamily mutation confers resistance to ethionine sulfoxide; uncharacterized protein 1085849 2893373 KLLA0_D12716g Kluyveromyces lactis uncharacterized protein XP_453629.1 1084062 R 28985 CDS KLLA0_D12738g 2893374 complement(1086914..1090000) D 1 NC_006040.1 highly similar to uniprot|P49095 Saccharomyces cerevisiae YMR189W GCV2 P subunit of the mitochondrial glycine decarboxylase complex required for the catabolism of glycine to 5 10-methylene-THF expression is regulated by levels of levels of 5 10-methylene-THF in the cytoplasm; glycine decarboxylase subunit P 1090000 2893374 KLLA0_D12738g Kluyveromyces lactis glycine decarboxylase subunit P XP_453630.1 1086914 R 28985 CDS KLLA0_D12760g 2893375 complement(1090428..1091909) D 1 NC_006040.1 weakly similar to uniprot|Q12523 Saccharomyces cerevisiae YPL247C Hypothetical ORF; uncharacterized protein 1091909 2893375 KLLA0_D12760g Kluyveromyces lactis uncharacterized protein XP_453631.1 1090428 R 28985 CDS KLLA0_D12782g 2893376 1092471..1093169 D 1 NC_006040.1 similar to uniprot|Q03246 Saccharomyces cerevisiae YMR188C MRPS17 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein uS17m 1093169 2893376 KLLA0_D12782g Kluyveromyces lactis mitochondrial 37S ribosomal protein uS17m XP_453632.1 1092471 D 28985 CDS KLLA0_D12804g 2893382 complement(1093369..1094184) D 1 NC_006040.1 similar to uniprot|Q12270 Saccharomyces cerevisiae YPL246C RBD2 Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p; uncharacterized protein 1094184 2893382 KLLA0_D12804g Kluyveromyces lactis uncharacterized protein XP_453633.1 1093369 R 28985 CDS KLLA0_D12826g 2893383 1094918..1096234 D 1 NC_006040.1 similar to uniprot|Q12179 Saccharomyces cerevisiae YPL245W Hypothetical ORF; uncharacterized protein 1096234 2893383 KLLA0_D12826g Kluyveromyces lactis uncharacterized protein XP_453634.1 1094918 D 28985 CDS KLLA0_D12848g 2893385 complement(1096275..1097294) D 1 NC_006040.1 similar to uniprot|Q12520 Saccharomyces cerevisiae YPL244C HUT1 Protein with a role in UDP-galactose transport to the Golgi lumen; UDP-galactose transporter HUT1 1097294 2893385 KLLA0_D12848g Kluyveromyces lactis UDP-galactose transporter HUT1 XP_453635.1 1096275 R 28985 CDS KLLA0_D12870g 2893386 1097784..1099538 D 1 NC_006040.1 similar to uniprot|P38687 Saccharomyces cerevisiae YPL243W SRP68 Component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane; signal recognition particle subunit SRP68 1099538 2893386 KLLA0_D12870g Kluyveromyces lactis signal recognition particle subunit SRP68 XP_453636.1 1097784 D 28985 CDS KLLA0_D12892g 2893266 1099951..1101315 D 1 NC_006040.1 weakly similar to uniprot|Q03236 Saccharomyces cerevisiae YMR187C Hypothetical ORF; uncharacterized protein 1101315 2893266 KLLA0_D12892g Kluyveromyces lactis uncharacterized protein XP_453637.1 1099951 D 28985 CDS KLLA0_D12914g 2893272 complement(1101471..1105955) D 1 NC_006040.1 similar to uniprot|Q12280 Saccharomyces cerevisiae YPL242C IQG1 Essential protein required for determination of budding pattern promotes localization of axial markers Bud4p and Cdc12p; uncharacterized protein 1105955 2893272 KLLA0_D12914g Kluyveromyces lactis uncharacterized protein XP_453638.1 1101471 R 28985 CDS KLLA0_D12936g 2893057 complement(join(1106301..1107070,1107164..1107245)) D 1 NC_006040.1 weakly similar to uniprot|P46670 Saccharomyces cerevisiae YPL241C CIN2 Tubulin folding factor C (putative) involved in beta-tubulin (Tub2p) folding isolated as mutant with increased chromosome loss and sensitivity to benomyl; uncharacterized protein 1107245 2893057 KLLA0_D12936g Kluyveromyces lactis uncharacterized protein XP_453639.1 1106301 R 28985 CDS KLLA0_D12958g 2893084 complement(1107587..1109728) D 1 NC_006040.1 highly similar to uniprot|P15108 Saccharomyces cerevisiae YMR186W HSC82 Cytoplasmic chaperone of the Hsp90 family; Hsp90 family chaperone HSP82 1109728 2893084 KLLA0_D12958g Kluyveromyces lactis Hsp90 family chaperone HSP82 XP_453640.1 1107587 R 28985 CDS KLLA0_D12980g 2893085 1110164..1111357 D 1 NC_006040.1 highly similar to uniprot|P38986 Saccharomyces cerevisiae YDR321W ASP1 Cytosolic L-asparaginase involved in asparagine catabolism; asparaginase ASP1 1111357 2893085 KLLA0_D12980g Kluyveromyces lactis asparaginase ASP1 XP_453641.1 1110164 D 28985 CDS KLLA0_D13002g 2893089 1111951..1112985 D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 1112985 2893089 KLLA0_D13002g Kluyveromyces lactis uncharacterized protein XP_453642.1 1111951 D 28985 CDS KLLA0_D13024g 2893312 1113372..1115516 D 1 NC_006040.1 highly similar to uniprot|P38795 Saccharomyces cerevisiae YHR074W QNS1 Glutamine-dependent NAD() synthetase essential for the formation of NAD() from nicotinic acid adenine dinucleotide; glutamine-dependent NAD(+) synthetase 1115516 2893312 KLLA0_D13024g Kluyveromyces lactis glutamine-dependent NAD(+) synthetase XP_453643.1 1113372 D 28985 CDS KLLA0_D13046g 2893320 complement(1115641..1116828) D 1 NC_006040.1 similar to uniprot|P38796 Saccharomyces cerevisiae YHR075C PPE1 Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit also identified as a small subunit mitochondrial ribosomal protein; phosphoprotein phosphatase methylesterase 1 1116828 2893320 KLLA0_D13046g Kluyveromyces lactis phosphoprotein phosphatase methylesterase 1 XP_453644.1 1115641 R 28985 CDS KLLA0_D13068g 2893094 complement(1117229..1119862) D 1 NC_006040.1 weakly similar to uniprot|P32454 Saccharomyces cerevisiae YKL157W APE2 Zinc-dependent metallopeptidase yscII and to YHR047C uniprot|P37898 Saccharomyces cerevisiae YHR047C AAP1' Arginine/alanine aminopeptidase; uncharacterized protein 1119862 2893094 KLLA0_D13068g Kluyveromyces lactis uncharacterized protein XP_453645.1 1117229 R 28985 CDS KLLA0_D13079g 9487530 complement(1120154..1120420) D 1 NC_006040.1 no similarity; uncharacterized protein 1120420 9487530 KLLA0_D13079g Kluyveromyces lactis uncharacterized protein XP_002999373.1 1120154 R 28985 CDS KLLA0_D13090g 2893148 1120945..1122036 D 1 NC_006040.1 similar to uniprot|Q06678 Saccharomyces cerevisiae YDR322W MRPL35 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein mL38 1122036 2893148 KLLA0_D13090g Kluyveromyces lactis mitochondrial 54S ribosomal protein mL38 XP_453646.1 1120945 D 28985 CDS KLLA0_D13112g 2893157 complement(1122669..1122959) D 1 NC_006040.1 similar to uniprot|P81449 Saccharomyces cerevisiae YDR322C-A TIM11 Subunit e of mitochondrial F1F0-ATPase which is a large evolutionarily conserved enzyme complex required for ATP synthesis essential for the dimeric state of ATP synthase; F1F0 ATP synthase subunit e 1122959 2893157 KLLA0_D13112g Kluyveromyces lactis F1F0 ATP synthase subunit e XP_453647.1 1122669 R 28985 CDS KLLA0_D13134g 2893199 1123794..1124843 D 1 NC_006040.1 similar to uniprot|P38797 Saccharomyces cerevisiae YHR076W PTC7 Mitochondrially localized type 2C protein phosphatase expression induced by growth on ethanol and by sustained osmotic stress possible role in carbon source utilization in low oxygen environments; type 2C protein phosphatase PTC7 1124843 2893199 KLLA0_D13134g Kluyveromyces lactis type 2C protein phosphatase PTC7 XP_453648.1 1123794 D 28985 CDS KLLA0_D13156g 2893192 complement(join(1124902..1128183,1128267..1128272)) D 1 NC_006040.1 similar to uniprot|P38798 Saccharomyces cerevisiae YHR077C NMD2 Protein involved in the nonsense-mediated mRNA decay (NMD) pathway interacts with Nam7p and Upf3p; uncharacterized protein 1128272 2893192 KLLA0_D13156g Kluyveromyces lactis uncharacterized protein XP_453649.1 1124902 R 28985 CDS KLLA0_D13178g 2893200 complement(1128555..1130129) D 1 NC_006040.1 similar to uniprot|P32609 Saccharomyces cerevisiae YDR323C PEP7 Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion which are essential for targeting of vesicles to the endosome required for vacuole inheritance; phosphatidylinositol-3-phosphate binding protein 1130129 2893200 KLLA0_D13178g Kluyveromyces lactis phosphatidylinositol-3-phosphate binding protein XP_453650.1 1128555 R 28985 CDS KLLA0_D13200g 2893201 1130332..1131984 D 1 NC_006040.1 similar to uniprot|P38799 Saccharomyces cerevisiae YHR078W Hypothetical ORF; uncharacterized protein 1131984 2893201 KLLA0_D13200g Kluyveromyces lactis uncharacterized protein XP_453651.1 1130332 D 28985 CDS KLLA0_D13222g 2893269 complement(1132067..1134277) D 1 NC_006040.1 similar to uniprot|Q06679 Saccharomyces cerevisiae YDR324C UTP4 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; uncharacterized protein 1134277 2893269 KLLA0_D13222g Kluyveromyces lactis uncharacterized protein XP_453652.1 1132067 R 28985 CDS KLLA0_D13244g 2893276 1134517..1137693 D 1 NC_006040.1 similar to uniprot|Q06680 Saccharomyces cerevisiae YDR325W YCG1 Yeast Condensin G; condensin subunit YCG1 1137693 2893276 KLLA0_D13244g Kluyveromyces lactis condensin subunit YCG1 XP_453653.1 1134517 D 28985 CDS KLLA0_D13266g 2893599 complement(1137750..1141208) D 1 NC_006040.1 similar to uniprot|P32361 Saccharomyces cerevisiae YHR079C IRE1 Serine-threonine kinase and endoribonuclease transmembrane protein that initiates the unfolded protein response signal by regulating synthesis of Hac1p through HAC1 mRNA splicing; bifunctional endoribonuclease/protein kinase IRE1 1141208 2893599 KLLA0_D13266g Kluyveromyces lactis bifunctional endoribonuclease/protein kinase IRE1 XP_453654.1 1137750 R 28985 CDS KLLA0_D13288g 2893606 1141866..1142561 D 1 NC_006040.1 no similarity; uncharacterized protein 1142561 2893606 KLLA0_D13288g Kluyveromyces lactis uncharacterized protein XP_453655.1 1141866 D 28985 CDS KLLA0_D13310g 2892737 complement(1143027..1144730) D 1 NC_006040.1 uniprot|P18631 Kluyveromyces lactis RAG1 Low-affinity glucose transporter; uncharacterized protein 1144730 2892737 KLLA0_D13310g Kluyveromyces lactis uncharacterized protein XP_453656.1 1143027 R 28985 CDS KLLA0_D13332g 2893433 complement(1146434..1147645) D 1 NC_006040.1 similar to uniprot|Q05515 Saccharomyces cerevisiae YDR346C SVF1 Protein with a potential role in cell survival pathways required for the diauxic growth shift expression in mammalian cells increases survival under conditions inducing apoptosis; uncharacterized protein 1147645 2893433 KLLA0_D13332g Kluyveromyces lactis uncharacterized protein XP_453657.1 1146434 R 28985 CDS KLLA0_D13354g 2893397 1148444..1150567 D 1 NC_006040.1 weakly similar to uniprot|P38766 Saccharomyces cerevisiae YHR031C RRM3 DNA helicase involved in rDNA replication and Ty1 transposition structurally and functionally related to Pif1p; DNA helicase 1150567 2893397 KLLA0_D13354g Kluyveromyces lactis DNA helicase XP_453658.1 1148444 D 28985 CDS KLLA0_D13376g 2893440 1150858..1152849 D 1 NC_006040.1 similar to uniprot|P40549 Saccharomyces cerevisiae YIL014W MNT3 Alpha-1 3-mannosyltransferase adds the fourth and fifth alpha-1 3-linked mannose residues to O-linked glycans during protein O-glycosylation; uncharacterized protein 1152849 2893440 KLLA0_D13376g Kluyveromyces lactis uncharacterized protein XP_453659.1 1150858 D 28985 CDS KLLA0_D13398g 2893445 1153371..1157345 D 1 NC_006040.1 some similarities with uniprot|P32521 YIR006C Saccharomyces cerevisiae PAN1 Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p; uncharacterized protein 1157345 2893445 KLLA0_D13398g Kluyveromyces lactis uncharacterized protein XP_453660.1 1153371 D 28985 CDS KLLA0_D13420g 2893454 complement(1157491..1157991) D 1 NC_006040.1 similar to uniprot|P40565 YIR005W Saccharomyces cerevisiae IST3 Component of the U2 snRNP required for the first catalytic step of splicing and for spliceosomal assembly; U2 snRNP complex subunit IST3 1157991 2893454 KLLA0_D13420g Kluyveromyces lactis U2 snRNP complex subunit IST3 XP_453661.1 1157491 R 28985 CDS KLLA0_D13442g 2893609 1158327..1159034 D 1 NC_006040.1 similar to uniprot|P40011 Saccharomyces cerevisiae YER010C Hypothetical ORF; bifunctional 4-hydroxy-4-methyl-2-oxoglutarate aldolase/oxaloacetate decarboxylase 1159034 2893609 KLLA0_D13442g Kluyveromyces lactis bifunctional 4-hydroxy-4-methyl-2-oxoglutarate aldolase/oxaloacetate decarboxylase XP_453662.1 1158327 D 28985 CDS KLLA0_D13464g 2893109 complement(1159251..1160552) D 1 NC_006040.1 similar to uniprot|P40564 YIR004W Saccharomyces cerevisiae DJP1 Cytosolic J-domain-containing protein, required for peroxisomal protein import; uncharacterized protein 1160552 2893109 KLLA0_D13464g Kluyveromyces lactis uncharacterized protein XP_453663.1 1159251 R 28985 CDS KLLA0_D13486g 2893000 complement(1160938..1162749) D 1 NC_006040.1 some similarities with uniprot|P40563 Saccharomyces cerevisiae YIR003W Hypothetical ORF; uncharacterized protein 1162749 2893000 KLLA0_D13486g Kluyveromyces lactis uncharacterized protein XP_453664.1 1160938 R 28985 CDS KLLA0_D13508g 2893416 complement(1162973..1163350) D 1 NC_006040.1 highly similar to uniprot|P33331 Saccharomyces cerevisiae YER009W NTF2 Nuclear envelope protein interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport; Ran GTPase-binding protein NTF2 1163350 2893416 KLLA0_D13508g Kluyveromyces lactis Ran GTPase-binding protein NTF2 XP_453665.1 1162973 R 28985 CDS KLLA0_D13530g 2893417 1163768..1167478 D 1 NC_006040.1 some similarities with uniprot|P33332 YER008C Saccharomyces cerevisiae SEC3 Non-essential subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p Exo84p); GTP-Rho binding exocyst subunit SEC3 1167478 2893417 KLLA0_D13530g Kluyveromyces lactis GTP-Rho binding exocyst subunit SEC3 XP_453666.1 1163768 D 28985 CDS KLLA0_D13552g 2893426 1167629..1170655 D 1 NC_006040.1 similar to uniprot|P40562 YIR002C Saccharomyces cerevisiae MPH1 Member of the DEAH family of helicases; 3'-5' DNA helicase 1170655 2893426 KLLA0_D13552g Kluyveromyces lactis 3'-5' DNA helicase XP_453667.2 1167629 D 28985 CDS KLLA0_D13574g 2893446 join(1171410..1171420,1171536..1172070) D 1 NC_006040.1 similar to uniprot|P89886 YER007C-A Saccharomyces cerevisiae TMA20 Protein of unknown function that associates with ribosomes; translation machinery-associated protein 20 1172070 2893446 KLLA0_D13574g Kluyveromyces lactis translation machinery-associated protein 20 XP_453668.2 1171410 D 28985 CDS KLLA0_D13596g 2893521 complement(1172223..1173701) D 1 NC_006040.1 similar to uniprot|P39937 Saccharomyces cerevisiae YER007W PAC2 Microtubule effector required for tubulin heterodimer formation binds alpha-tubulin required for normal microtubule function null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl; uncharacterized protein 1173701 2893521 KLLA0_D13596g Kluyveromyces lactis uncharacterized protein XP_453669.1 1172223 R 28985 CDS KLLA0_D13618g 2893563 complement(1174077..1175669) D 1 NC_006040.1 similar to uniprot|P40010 Saccharomyces cerevisiae YER006W NUG1 GTPase that associates with nuclear 60S pre-ribosomes required for export of 60S ribosomal subunits from the nucleus; RNA-binding GTPase NUG1 1175669 2893563 KLLA0_D13618g Kluyveromyces lactis RNA-binding GTPase NUG1 XP_453670.1 1174077 R 28985 CDS KLLA0_D13640g 2893512 1176601..1177674 D 1 NC_006040.1 uniprot|Q05959 Kluyveromyces lactis KLLA0D13640g SUA7 Transcription initiation factor IIB; transcription factor TFIIB 1177674 2893512 KLLA0_D13640g Kluyveromyces lactis transcription factor TFIIB XP_453671.1 1176601 D 28985 CDS KLLA0_D13662g 2892954 complement(1178179..1180143) D 1 NC_006040.1 similar to uniprot|P40009 YER005W Saccharomyces cerevisiae YND1 Yeast Nucleoside Diphosphatase; apyrase 1180143 2892954 KLLA0_D13662g Kluyveromyces lactis apyrase XP_453672.1 1178179 R 28985 CDS KLLA0_D13684g 2892911 complement(1180483..1181157) D 1 NC_006040.1 similar to uniprot|P40008 Saccharomyces cerevisiae YER004W FMP52 The authentic non-tagged protein was localized to the mitochondria; uncharacterized protein 1181157 2892911 KLLA0_D13684g Kluyveromyces lactis uncharacterized protein XP_453673.1 1180483 R 28985 CDS KLLA0_D13706g 2893380 complement(1181451..1182107) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 1182107 2893380 KLLA0_D13706g Kluyveromyces lactis uncharacterized protein XP_453674.1 1181451 R 28985 CDS KLLA0_D13728g 2893381 1182559..1183845 D 1 NC_006040.1 highly similar to uniprot|P29952 YER003C Saccharomyces cerevisiae PMI40 mannose-6-phosphate isomerase; mannose-6-phosphate isomerase PMI40 1183845 2893381 KLLA0_D13728g Kluyveromyces lactis mannose-6-phosphate isomerase PMI40 XP_453675.1 1182559 D 28985 CDS KLLA0_D13750g 2893384 complement(1184048..1184767) D 1 NC_006040.1 similar to uniprot|P40007 YER002W Saccharomyces cerevisiae NOP16 Constituent of 66S pre-ribosomal particles involved in 60S ribosomal subunit biogenesis; uncharacterized protein 1184767 2893384 KLLA0_D13750g Kluyveromyces lactis uncharacterized protein XP_453676.1 1184048 R 28985 CDS KLLA0_D13772g 2892946 1185663..1186700 D 1 NC_006040.1 some similarities with uniprot|P40561 Saccharomyces cerevisiae YIR001C SGN1 Cytoplasmic RNA-binding protein contains an RNA recognition motif (RRM) may have a role in mRNA translation as suggested by genetic interactions with genes encoding proteins involved in translational initiation; uncharacterized protein 1186700 2892946 KLLA0_D13772g Kluyveromyces lactis uncharacterized protein XP_453677.1 1185663 D 28985 CDS KLLA0_D13816g 2892972 1188279..1188995 D 1 NC_006040.1 similar to uniprot|P40006 Saccharomyces cerevisiae YEL001C Hypothetical ORF; uncharacterized protein 1188995 2892972 KLLA0_D13816g Kluyveromyces lactis uncharacterized protein XP_453678.1 1188279 D 28985 CDS KLLA0_D13838g 2892719 complement(1189057..1190595) D 1 NC_006040.1 similar to uniprot|P40560 YIL001W Saccharomyces cerevisiae Hypothetical ORF; uncharacterized protein 1190595 2892719 KLLA0_D13838g Kluyveromyces lactis uncharacterized protein XP_453679.1 1189057 R 28985 CDS KLLA0_D13860g 2892766 1190927..1193752 D 1 NC_006040.1 similar to uniprot|P40559 YIL002C Saccharomyces cerevisiae INP51 Phosphatidylinositol 4 5-bisphosphate 5-phosphatase; phosphoinositide 5-phosphatase INP51 1193752 2892766 KLLA0_D13860g Kluyveromyces lactis phosphoinositide 5-phosphatase INP51 XP_453680.1 1190927 D 28985 CDS KLLA0_D13871g 9487516 complement(1193813..1194040) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 1194040 9487516 KLLA0_D13871g Kluyveromyces lactis uncharacterized protein XP_002999374.1 1193813 R 28985 CDS KLLA0_D13882g 2892820 1194407..1195705 D 1 NC_006040.1 similar to uniprot|P33767 YEL002C Saccharomyces cerevisiae WBP1 wheat germ agglutinin-binding protein oligosaccharyl transferase glycoprotein complex beta subunit; dolichyl-diphosphooligosaccharide-protein glycotransferase 1195705 2892820 KLLA0_D13882g Kluyveromyces lactis dolichyl-diphosphooligosaccharide-protein glycotransferase XP_453681.1 1194407 D 28985 CDS KLLA0_D13904g 2892999 complement(join(1195920..1196236,1196332..1196350)) D 1 NC_006040.1 similar to uniprot|P40005 YEL003w Saccharomyces cerevisiae GIM4 subunit of the heterohexameric cochaperone prefoldin complex; tubulin-binding prefolding complex subunit GIM4 1196350 2892999 KLLA0_D13904g Kluyveromyces lactis tubulin-binding prefolding complex subunit GIM4 XP_453682.2 1195920 R 28985 CDS KLLA0_D13926g 2892939 complement(1196673..1197686) D 1 NC_006040.1 similar to uniprot|P40004 Saccharomyces cerevisiae YEL004W; uncharacterized protein 1197686 2892939 KLLA0_D13926g Kluyveromyces lactis uncharacterized protein XP_453683.1 1196673 R 28985 CDS KLLA0_D13948g 2892968 1198201..1199046 D 1 NC_006040.1 weakly similar to uniprot|P40003 Saccharomyces cerevisiae YEL005C VAB2 Protein with a potential role in vacuolar function; uncharacterized protein 1199046 2892968 KLLA0_D13948g Kluyveromyces lactis uncharacterized protein XP_453684.1 1198201 D 28985 CDS KLLA0_D13970g 2892969 complement(1199071..1199922) D 1 NC_006040.1 similar to uniprot|P40558 Saccharomyces cerevisiae YIL003W CFD1 Highly conserved putative P-loop ATPase localized in the cytoplasm has a potential role in assembly of iron-sulfur clusters in proteins; iron-sulfur cluster assembly protein CFD1 1199922 2892969 KLLA0_D13970g Kluyveromyces lactis iron-sulfur cluster assembly protein CFD1 XP_453685.1 1199071 R 28985 CDS KLLA0_D13992g 2892979 1200329..1200772 D 1 NC_006040.1 similar to uniprot|P22804 Saccharomyces cerevisiae YIL004C; uncharacterized protein 1200772 2892979 KLLA0_D13992g Kluyveromyces lactis uncharacterized protein XP_453686.1 1200329 D 28985 CDS KLLA0_D14014g 2893086 complement(1200970..1203090) D 1 NC_006040.1 similar to uniprot|P40557 YIL005W Saccharomyces cerevisiae EPS1 protein disulfide isomerase related protein involved in endoplasmic reticulum retention of resident ER proteins; protein disulfide isomerase EPS1 1203090 2893086 KLLA0_D14014g Kluyveromyces lactis protein disulfide isomerase EPS1 XP_453687.1 1200970 R 28985 CDS KLLA0_D14036g 2893083 complement(1203522..1204817) D 1 NC_006040.1 similar to uniprot|P40556 Saccharomyces cerevisiae YIL006W Pvruvate transporter of the mitochondrial inner membrane member of the mitochondrial carrier family has putative mouse and human orthologs; NAD+ transporter 1204817 2893083 KLLA0_D14036g Kluyveromyces lactis NAD+ transporter XP_453688.1 1203522 R 28985 CDS KLLA0_D14058g 2893150 complement(1205424..1206932) D 1 NC_006040.1 some similarities with uniprot|P40002 Saccharomyces cerevisiae YEL007W Hypothetical ORF and some similarities with YHR177W uniprot|P38867 Saccharomyces cerevisiae YHR177W; uncharacterized protein 1206932 2893150 KLLA0_D14058g Kluyveromyces lactis uncharacterized protein XP_453689.1 1205424 R 28985 CDS KLLA0_D14113g 2893223 1209913..1210914 D 1 NC_006040.1 similar to uniprot|P03069 Saccharomyces cerevisiae YEL009C GCN4 Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation expression is tightly regulated at both the transcriptional and translational levels; amino acid starvation-responsive transcription factor GCN4 1210914 2893223 KLLA0_D14113g Kluyveromyces lactis amino acid starvation-responsive transcription factor GCN4 XP_453692.1 1209913 D 28985 CDS KLLA0_D14135g 2893277 1211322..1212077 D 1 NC_006040.1 weakly similar to uniprot|P40555 Saccharomyces cerevisiae YIL007C NAS2 Protein with similarity to the p27 subunit of mammalian proteasome modulator not essential interacts with Rpn4p; uncharacterized protein 1212077 2893277 KLLA0_D14135g Kluyveromyces lactis uncharacterized protein XP_453693.1 1211322 D 28985 CDS KLLA0_D14157g 2893519 complement(1212133..1212438) D 1 NC_006040.1 highly similar to uniprot|P40554 YIL008W Saccharomyces cerevisiae URM1 Ubiquitin-like protein with only weak sequence similarity to ubiquitin; ubiquitin-related modifier URM1 1212438 2893519 KLLA0_D14157g Kluyveromyces lactis ubiquitin-related modifier URM1 XP_453695.1 1212133 R 28985 CDS KLLA0_D14201g 2893585 1213327..1215078 D 1 NC_006040.1 similar to uniprot|P06208 Saccharomyces cerevisiae YNL104C LEU4 Alpha-isopropylmalate synthase (2-isopropylmalate synthase) the main isozyme responsible for the first step in the leucine biosynthesis pathway; uncharacterized protein 1215078 2893585 KLLA0_D14201g Kluyveromyces lactis uncharacterized protein XP_453696.1 1213327 D 28985 CDS KLLA0_D14289g 2893054 1215729..1216283 D 1 NC_006040.1 similar to uniprot|Q03096 Saccharomyces cerevisiae YIL009C-A EST3 Component of the telomerase holoenzyme involved in telomere replication; telomerase subunit EST3 1216283 2893054 KLLA0_D14289g Kluyveromyces lactis telomerase subunit EST3 XP_453697.1 1215729 D 28985 CDS KLLA0_D14311g 2892829 1216574..1217905 D 1 NC_006040.1 similar to uniprot|Q00776 Saccharomyces cerevisiae YPL259C APM1 medium subunit of the clathrin-associated protein complex; uncharacterized protein 1217905 2892829 KLLA0_D14311g Kluyveromyces lactis uncharacterized protein XP_453698.1 1216574 D 28985 CDS KLLA0_D14333g 2892709 complement(1218148..1218765) D 1 NC_006040.1 similar to uniprot|P40553 Saccharomyces cerevisiae YIL010W DOT5 Nuclear thiol peroxidase; thioredoxin peroxidase DOT5 1218765 2892709 KLLA0_D14333g Kluyveromyces lactis thioredoxin peroxidase DOT5 XP_453699.1 1218148 R 28985 CDS KLLA0_D14355g 2892772 complement(1219658..1221424) D 1 NC_006040.1 similar to uniprot|Q08977 YPL260W Saccharomyces cerevisiae Hypothetical ORF; uncharacterized protein 1221424 2892772 KLLA0_D14355g Kluyveromyces lactis uncharacterized protein XP_453700.1 1219658 R 28985 CDS KLLA0_D14377g 2892874 complement(1221875..1223158) D 1 NC_006040.1 some similarities with uniprot|P54867 Saccharomyces cerevisiae YOR008C SLG1 Protein involved in cell wall integrity and stress response; uncharacterized protein 1223158 2892874 KLLA0_D14377g Kluyveromyces lactis uncharacterized protein XP_453701.1 1221875 R 28985 CDS KLLA0_D14399g 2892753 1224490..1226067 D 1 NC_006040.1 some similarities with uniprot|P40574 Saccharomyces cerevisiae YIR018W YAP5 bZIP transcription factor; uncharacterized protein 1226067 2892753 KLLA0_D14399g Kluyveromyces lactis uncharacterized protein XP_453702.1 1224490 D 28985 CDS KLLA0_D14421g 2892754 complement(1226243..1227655) D 1 NC_006040.1 similar to uniprot|Q08193 Saccharomyces cerevisiae YOL030W GAS5 Putative 1,3-beta-glucanosyltransferase has similarity to Gas1p localizes to the cell wall; 1,3-beta-glucanosyltransferase 1227655 2892754 KLLA0_D14421g Kluyveromyces lactis 1,3-beta-glucanosyltransferase XP_453703.1 1226243 R 28985 CDS KLLA0_D14487g 2893566 1229115..1229645 D 1 NC_006040.1 similar to uniprot|Q03677 Saccharomyces cerevisiae YMR009W ADI1 Predicted acireductone dioxygenease of the methionine salvage pathway; acireductone dioxygenase (Ni2+-requiring) 1229645 2893566 KLLA0_D14487g Kluyveromyces lactis acireductone dioxygenase (Ni2+-requiring) XP_453704.1 1229115 D 28985 CDS KLLA0_D14509g 2892913 1230053..1231135 D 1 NC_006040.1 similar to uniprot|Q03687 YMR010W Saccharomyces cerevisiae Protein of unknown function; uncharacterized protein 1231135 2892913 KLLA0_D14509g Kluyveromyces lactis uncharacterized protein XP_453705.1 1230053 D 28985 CDS KLLA0_D14531g 2893595 complement(1231373..1233487) D 1 NC_006040.1 similar to uniprot|P32606 YOR017W Saccharomyces cerevisiae PET127 Protein with a role in mitochondrial RNA stability and/or processing; uncharacterized protein 1233487 2893595 KLLA0_D14531g Kluyveromyces lactis uncharacterized protein XP_453706.1 1231373 R 28985 CDS KLLA0_D14553g 2893077 1234322..1235584 D 1 NC_006040.1 similar to uniprot|P23180 Saccharomyces cerevisiae YHL021C FMP12 The authentic non-tagged protein was localized to the mitochondria; uncharacterized protein 1235584 2893077 KLLA0_D14553g Kluyveromyces lactis uncharacterized protein XP_453707.1 1234322 D 28985 CDS KLLA0_D14575g 2893143 1235601..1236806 D 1 NC_006040.1 weakly similar to uniprot|P23179 Saccharomyces cerevisiae YHL022C SPO11 Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction required for homologous chromosome pairing and synaptonemal complex formation; DNA topoisomerase (ATP-hydrolyzing) 1236806 2893143 KLLA0_D14575g Kluyveromyces lactis DNA topoisomerase (ATP-hydrolyzing) XP_453708.1 1235601 D 28985 CDS KLLA0_D14641g 2893165 1237252..1237878 D 1 NC_006040.1 similar to uniprot|P39704 Saccharomyces cerevisiae YAL007C ERP2 Protein that forms a heterotrimeric complex with Erp1p Emp24p and Erv25p member along with Emp24p and Erv25p of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles; uncharacterized protein 1237878 2893165 KLLA0_D14641g Kluyveromyces lactis uncharacterized protein XP_453709.1 1237252 D 28985 CDS KLLA0_D14663g 2893213 1238190..1239416 D 1 NC_006040.1 similar to uniprot|Q06103 Saccharomyces cerevisiae YPR108W; proteasome regulatory particle lid subunit RPN7 1239416 2893213 KLLA0_D14663g Kluyveromyces lactis proteasome regulatory particle lid subunit RPN7 XP_453710.1 1238190 D 28985 CDS KLLA0_D14685g 2893608 1240247..1241899 D 1 NC_006040.1 similar to uniprot|P06115 Saccharomyces cerevisiae YGR088W CTT1 Cytosolic catalase T has a role in protection from oxidative damage by hydrogen peroxide; catalase T 1241899 2893608 KLLA0_D14685g Kluyveromyces lactis catalase T XP_453711.1 1240247 D 28985 CDS KLLA0_D14707g 2893405 1242483..1245125 D 1 NC_006040.1 similar to uniprot|P53253 Saccharomyces cerevisiae YGR089W NNF2 Protein that exhibits physical and genetic interactions with Rpb8p which is a subunit of RNA polymerases I II and III computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation; uncharacterized protein 1245125 2893405 KLLA0_D14707g Kluyveromyces lactis uncharacterized protein XP_453712.1 1242483 D 28985 CDS KLLA0_D14762g 2893392 complement(1246745..1247149) D 1 NC_006040.1 no similarity; uncharacterized protein 1247149 2893392 KLLA0_D14762g Kluyveromyces lactis uncharacterized protein XP_453715.1 1246745 R 28985 CDS KLLA0_D14806g 2893378 1247991..1251629 D 1 NC_006040.1 similar to uniprot|P53254 Saccharomyces cerevisiae YGR090W UTP22 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA based on computational analysis of large-scale protein-protein interaction data; rRNA-processing protein UTP22 1251629 2893378 KLLA0_D14806g Kluyveromyces lactis rRNA-processing protein UTP22 XP_453716.1 1247991 D 28985 CDS KLLA0_D14828g 2893379 1251991..1252524 D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 1252524 2893379 KLLA0_D14828g Kluyveromyces lactis uncharacterized protein XP_453717.1 1251991 D 28985 CDS KLLA0_D14861g 2892806 complement(1253023..1254027) D 1 NC_006040.1 highly similar to uniprot|P07703 Saccharomyces cerevisiae YPR110C RPC40 RNA polymerase subunit common to RNA polymerase I and III; DNA-directed RNA polymerase core subunit RPC40 1254027 2892806 KLLA0_D14861g Kluyveromyces lactis DNA-directed RNA polymerase core subunit RPC40 XP_453719.1 1253023 R 28985 CDS KLLA0_D14883g 2892805 1254381..1255784 D 1 NC_006040.1 weakly similar to uniprot|P49704 Saccharomyces cerevisiae YGR091W PRP31 Splicing factor component of the U4/U6-U5 snRNP complex; U4/U6-U5 snRNP complex subunit PRP31 1255784 2892805 KLLA0_D14883g Kluyveromyces lactis U4/U6-U5 snRNP complex subunit PRP31 XP_453720.1 1254381 D 28985 CDS KLLA0_D14905g 2893087 1256065..1257768 D 1 NC_006040.1 similar to uniprot|P22204 Saccharomyces cerevisiae YGR092W DBF2 Ser/Thr kinase involved in transcription and stress response functions as part of a network of genes in exit from mitosis localization is cell cycle regulated activated by Cdc15p during the exit from mitosis; uncharacterized protein 1257768 2893087 KLLA0_D14905g Kluyveromyces lactis uncharacterized protein XP_453721.1 1256065 D 28985 CDS KLLA0_D14927g 2893088 1258177..1259700 D 1 NC_006040.1 similar to uniprot|P53255 Saccharomyces cerevisiae YGR093W Hypothetical ORF; uncharacterized protein 1259700 2893088 KLLA0_D14927g Kluyveromyces lactis uncharacterized protein XP_453722.1 1258177 D 28985 CDS KLLA0_D14949g 2893292 complement(1259860..1262496) D 1 NC_006040.1 similar to uniprot|Q06106 Saccharomyces cerevisiae YPR112C MRD1 Essential conserved protein that associates with 35S precursor rRNA and is required for its initial processing at the A(0)-A(2) cleavage sites shows partial nucleolar localization contains five consensus RNA-binding domains; RNA-binding ribosome biosynthesis protein MRD1 1262496 2893292 KLLA0_D14949g Kluyveromyces lactis RNA-binding ribosome biosynthesis protein MRD1 XP_453723.1 1259860 R 28985 CDS KLLA0_D14971g 2893133 1263323..1266598 D 1 NC_006040.1 highly similar to uniprot|P07806 Saccharomyces cerevisiae YGR094W VAS1 mitochondrial and cytoplasmic valyl-tRNA synthetase; valine--tRNA ligase 1266598 2893133 KLLA0_D14971g Kluyveromyces lactis valine--tRNA ligase XP_453724.1 1263323 D 28985 CDS KLLA0_D14993g 2893140 complement(1266752..1267429) D 1 NC_006040.1 similar to uniprot|P53256 Saccharomyces cerevisiae YGR095C RRP46 Ribosomal RNA Processing Putative 3'->5' exoribonuclease component of exosome complex of 3'->5' exonucleases; exosome non-catalytic core subunit RRP46 1267429 2893140 KLLA0_D14993g Kluyveromyces lactis exosome non-catalytic core subunit RRP46 XP_453725.1 1266752 R 28985 CDS KLLA0_D15015g 2893179 1267803..1268756 D 1 NC_006040.1 similar to uniprot|P53257 Saccharomyces cerevisiae YGR096W TPC1 Tpc1p is a transporter that catalyzes the uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria it is located in the mitochondrial membrane and its expression appears to be regulated by carbon source; thiamine transporter TPC1 1268756 2893179 KLLA0_D15015g Kluyveromyces lactis thiamine transporter TPC1 XP_453726.1 1267803 D 28985 CDS KLLA0_D15037g 2893215 1269125..1269802 D 1 NC_006040.1 similar to uniprot|P06197 Saccharomyces cerevisiae YPR113W PIS1 Phosphatidylinositol synthase required for biosynthesis of phosphatidylinositol which is a precursor for polyphosphoinositides sphingolipids and glycolipid anchors for some of the plasma membrane proteins; CDP-diacylglycerol--inositol 3-phosphatidyltransferase 1269802 2893215 KLLA0_D15037g Kluyveromyces lactis CDP-diacylglycerol--inositol 3-phosphatidyltransferase XP_453727.1 1269125 D 28985 CDS KLLA0_D15059g 2893216 1270160..1271146 D 1 NC_006040.1 similar to uniprot|Q06107 Saccharomyces cerevisiae YPR114W Hypothetical ORF; uncharacterized protein 1271146 2893216 KLLA0_D15059g Kluyveromyces lactis uncharacterized protein XP_453728.1 1270160 D 28985 CDS KLLA0_D15081g 2893241 1271696..1274728 D 1 NC_006040.1 some similarities with Saccharomyces cerevisiae YPR115W Hypothetical ORF and to YGR097W uniprot|P48361 Saccharomyces cerevisiae YGR097W ASK10 Component of the RNA polymerase II holoenzyme phosphorylated in response to oxidative stress has a role in destruction of Ssn8p which relieves repression of stress-response genes; uncharacterized protein 1274728 2893241 KLLA0_D15081g Kluyveromyces lactis uncharacterized protein XP_453729.1 1271696 D 28985 CDS KLLA0_D15103g 2893271 complement(1275080..1275745) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 1275745 2893271 KLLA0_D15103g Kluyveromyces lactis uncharacterized protein XP_453730.1 1275080 R 28985 CDS KLLA0_D15125g 2893395 1275978..1276826 D 1 NC_006040.1 weakly similar to uniprot|Q06109 Saccharomyces cerevisiae YPR116W Hypothetical ORF; uncharacterized protein 1276826 2893395 KLLA0_D15125g Kluyveromyces lactis uncharacterized protein XP_453731.1 1275978 D 28985 CDS KLLA0_D15136g 2893387 complement(1276819..1281594) D 1 NC_006040.1 similar to uniprot|Q03018 Saccharomyces cerevisiae YGR098C ESP1 Separase with cysteine protease activity (related to caspases) that promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin inhibited by Pds1p; separase 1281594 2893387 KLLA0_D15136g Kluyveromyces lactis separase XP_453732.1 1276819 R 28985 CDS KLLA0_D15158g 2893388 1281895..1283895 D 1 NC_006040.1 similar to uniprot|P53038 Saccharomyces cerevisiae YGR099W TEL2 Essential DNA-binding protein specific to single-stranded yeast telomeric DNA repeats required for telomere length regulation and telomere position effect; uncharacterized protein 1283895 2893388 KLLA0_D15158g Kluyveromyces lactis uncharacterized protein XP_453733.1 1281895 D 28985 CDS KLLA0_D15180g 2893539 1284273..1291412 D 1 NC_006040.1 weakly similar to uniprot|Q06116 Saccharomyces cerevisiae YPR117W Hypothetical ORF; uncharacterized protein 1291412 2893539 KLLA0_D15180g Kluyveromyces lactis uncharacterized protein XP_453734.1 1284273 D 28985 CDS KLLA0_D15202g 2893118 1291872..1294706 D 1 NC_006040.1 similar to uniprot|P53258 Saccharomyces cerevisiae YGR100W MDR1 Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p Ypt31p and Sec4p involved in recycling of internalized proteins and regulation of Golgi secretory function; GTPase-activating protein MDR1 1294706 2893118 KLLA0_D15202g Kluyveromyces lactis GTPase-activating protein MDR1 XP_453735.1 1291872 D 28985 CDS KLLA0_D15224g 2893510 1294983..1296014 D 1 NC_006040.1 similar to uniprot|P53259 Saccharomyces cerevisiae YGR101W PCP1 Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology belongs to the rhomboid-GlpG superfamily of intramembrane peptidases; rhomboid protease PCP1 1296014 2893510 KLLA0_D15224g Kluyveromyces lactis rhomboid protease PCP1 XP_453736.1 1294983 D 28985 CDS KLLA0_D15246g 2893527 complement(1296105..1296629) D 1 NC_006040.1 similar to uniprot|P53260 Saccharomyces cerevisiae YGR102C Hypothetical ORF; glutamyl-tRNA(Gln) amidotransferase subunit F 1296629 2893527 KLLA0_D15246g Kluyveromyces lactis glutamyl-tRNA(Gln) amidotransferase subunit F XP_453737.1 1296105 R 28985 CDS KLLA0_D15268g 2892745 1297155..1298972 D 1 NC_006040.1 similar to uniprot|P53261 Saccharomyces cerevisiae YGR103W NOP7 Nucleolar protein involved in rRNA processing and 60S ribosomal subunit biogenesis constituent of several different pre-ribosomal particles; mRNA-binding ribosome synthesis protein NOP7 1298972 2892745 KLLA0_D15268g Kluyveromyces lactis mRNA-binding ribosome synthesis protein NOP7 XP_453738.1 1297155 D 28985 CDS KLLA0_D15290g 2892746 complement(1299227..1299994) D 1 NC_006040.1 similar to uniprot|P32585 Saccharomyces cerevisiae YGR104C SRB5 subunit of RNA polymerase II holoenzyme/mediator complex; uncharacterized protein 1299994 2892746 KLLA0_D15290g Kluyveromyces lactis uncharacterized protein XP_453739.1 1299227 R 28985 CDS KLLA0_D15312g 2892788 join(1300224..1300243,1300334..1300547) D 1 NC_006040.1 similar to uniprot|P41806 Saccharomyces cerevisiae YGR105W VMA21 Protein involved in vacuolar H -ATPase assembly or function required for the biogenesis of a functional vacuolar ATPase (V-ATPase) but not part of the final enzyme complex; uncharacterized protein 1300547 2892788 KLLA0_D15312g Kluyveromyces lactis uncharacterized protein XP_453740.2 1300224 D 28985 CDS KLLA0_D15334g 2893123 complement(1300663..1301466) D 1 NC_006040.1 weakly similar to uniprot|P53262 Saccharomyces cerevisiae YGR106C Hypothetical ORF; uncharacterized protein 1301466 2893123 KLLA0_D15334g Kluyveromyces lactis uncharacterized protein XP_453741.1 1300663 R 28985 CDS KLLA0_D15356g 2892917 1301848..1303722 D 1 NC_006040.1 some similarities with uniprot|P21657 Saccharomyces cerevisiae YIR023W DAL81 Positive regulator of genes in multiple nitrogen degradation pathways; uncharacterized protein 1303722 2892917 KLLA0_D15356g Kluyveromyces lactis uncharacterized protein XP_453742.1 1301848 D 28985 CDS KLLA0_D15378g 2893135 complement(1303787..1306396) D 1 NC_006040.1 similar to uniprot|Q06593 Saccharomyces cerevisiae YPR194C OPT2 Oligopeptide transporter member of the OPT family with potential orthologs in S. pombe and C. albicans; uncharacterized protein 1306396 2893135 KLLA0_D15378g Kluyveromyces lactis uncharacterized protein XP_453743.1 1303787 R 28985 CDS KLLA0_D15400g 2893136 1307549..1308832 D 1 NC_006040.1 weakly similar to uniprot|Q0CQA0 Aspergillus terreus NIH2624 ATEG_04134 Predicted protein; uncharacterized protein 1308832 2893136 KLLA0_D15400g Kluyveromyces lactis uncharacterized protein XP_453744.1 1307549 D 28985 CDS KLLA0_D15455g 2893603 1309647..1310870 D 1 NC_006040.1 similar to uniprot|Q06489 Saccharomyces cerevisiae YPR118W Methylthioribose-1-phosphate isomerase catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway; S-methyl-5-thioribose-1-phosphate isomerase MRI1 1310870 2893603 KLLA0_D15455g Kluyveromyces lactis S-methyl-5-thioribose-1-phosphate isomerase MRI1 XP_453746.1 1309647 D 28985 CDS KLLA0_D15521g 2893531 1311601..1312371 D 1 NC_006040.1 similar to uniprot|P32573 Saccharomyces cerevisiae YNL202W SPS19 late sporulation specific gene which may function during spore wall formation; peroxisomal 2,4-dienoyl-CoA reductase; uncharacterized protein 1312371 2893531 KLLA0_D15521g Kluyveromyces lactis uncharacterized protein XP_453747.1 1311601 D 28985 CDS KLLA0_D15543g 2893517 1313760..1315379 D 1 NC_006040.1 similar to uniprot|P24869 Saccharomyces cerevisiae YPR119W CLB2 Involved in mitotic induction G(sub)2-specific B-type cyclin and uniprot|P24868 Saccharomyces cerevisiae YGR108W CLB1; uncharacterized protein 1315379 2893517 KLLA0_D15543g Kluyveromyces lactis uncharacterized protein XP_453748.1 1313760 D 28985 CDS KLLA0_D15565g 2893537 complement(1316125..1317351) D 1 NC_006040.1 similar to uniprot|P30283 Saccharomyces cerevisiae YPR120C CLB5 B-type cyclin with a role in DNA replication during S phase has an additional functional role in formation of mitotic spindles along with Clb3p and Clb4p and uniprot|P32943 Saccharomyces cerevisiae YGR109C CLB6; uncharacterized protein 1317351 2893537 KLLA0_D15565g Kluyveromyces lactis uncharacterized protein XP_453749.1 1316125 R 28985 CDS KLLA0_D15576g 9487277 1318387..1318641 D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 1318641 9487277 KLLA0_D15576g Kluyveromyces lactis uncharacterized protein XP_002999375.1 1318387 D 28985 CDS KLLA0_D15631g 2893402 1319185..1322697 D 1 NC_006040.1 similar to uniprot|P40851 Saccharomyces cerevisiae YPR122W AXL1 Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone required for axial budding pattern of haploid cells; uncharacterized protein 1322697 2893402 KLLA0_D15631g Kluyveromyces lactis uncharacterized protein XP_453750.1 1319185 D 28985 CDS KLLA0_D15653g 2892733 1323360..1324583 D 1 NC_006040.1 similar to uniprot|P53265 Saccharomyces cerevisiae YGR111W Hypothetical ORF; uncharacterized protein 1324583 2892733 KLLA0_D15653g Kluyveromyces lactis uncharacterized protein XP_453751.1 1323360 D 28985 CDS KLLA0_D15697g 2893442 1325624..1326070 D 1 NC_006040.1 highly similar to YBR252W, uniprot|P33317 Saccharomyces cerevisiae YBR252W (DUT1); bifunctional dITP/dUTP diphosphatase 1326070 2893442 KLLA0_D15697g Kluyveromyces lactis bifunctional dITP/dUTP diphosphatase XP_453752.1 1325624 D 28985 CDS KLLA0_D15719g 2893569 1326369..1326734 D 1 NC_006040.1 similar to uniprot|P32570 Saccharomyces cerevisiae YBR253W SRB6 Protein involved in transcription as part of the Srb/Mediator complex; uncharacterized protein 1326734 2893569 KLLA0_D15719g Kluyveromyces lactis uncharacterized protein XP_453753.1 1326369 D 28985 CDS KLLA0_D15741g 2893591 1327061..1328536 D 1 NC_006040.1 weakly similar to uniprot|P40568 Saccharomyces cerevisiae YIR010W DSN1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules important for chromosome segregation; MIND complex subunit DSN1 1328536 2893591 KLLA0_D15741g Kluyveromyces lactis MIND complex subunit DSN1 XP_453754.1 1327061 D 28985 CDS KLLA0_D15763g 2893592 complement(1328758..1329234) D 1 NC_006040.1 similar to uniprot|P38334 Saccharomyces cerevisiae YBR254C TRS20 Trapp subunit of 20 kDa probable membrane protein mutations in the human homolog cause spondyloepiphyseal dysplasia tarda (SEDL) a genetically heterogeneous disorder characterized by short stature and early-onset osteoarthritis; TRAPP subunit TRS20 1329234 2893592 KLLA0_D15763g Kluyveromyces lactis TRAPP subunit TRS20 XP_453755.1 1328758 R 28985 CDS KLLA0_D15807g 2892755 1330010..1331644 D 1 NC_006040.1 some similarities with uniprot|P38335 Saccharomyces cerevisiae YBR255W Protein of unknown function required for normal growth rate at 15 degrees C green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; uncharacterized protein 1331644 2892755 KLLA0_D15807g Kluyveromyces lactis uncharacterized protein XP_453756.1 1330010 D 28985 CDS KLLA0_D15829g 2892783 complement(1331795..1332157) D 1 NC_006040.1 similar to uniprot|Q3E776 Saccharomyces cerevisiae YBR255C-A Hypothetical ORF identified by homology; uncharacterized protein 1332157 2892783 KLLA0_D15829g Kluyveromyces lactis uncharacterized protein XP_453757.1 1331795 R 28985 CDS KLLA0_D15851g 2892784 complement(1332568..1333569) D 1 NC_006040.1 some similarities with uniprot|P38637 Saccharomyces cerevisiae YIR011C STS1 Protein that interacts with the karyopherin Srp1p; uncharacterized protein 1333569 2892784 KLLA0_D15851g Kluyveromyces lactis uncharacterized protein XP_453758.1 1332568 R 28985 CDS KLLA0_D15873g 2892786 1334131..1335426 D 1 NC_006040.1 similar to uniprot|P35184 Saccharomyces cerevisiae YIR012W SQT1 Protein involved in a late step of 60S ribosomal subunit assembly or modification contains multiple WD repeats interacts with Qsr1p in the two-hybrid system; uncharacterized protein 1335426 2892786 KLLA0_D15873g Kluyveromyces lactis uncharacterized protein XP_453759.1 1334131 D 28985 CDS KLLA0_D15895g 2893572 complement(1335523..1336230) D 1 NC_006040.1 highly similar to uniprot|P38145 Saccharomyces cerevisiae YBR256C RIB5 Riboflavin synthase catalyzes the last step of the riboflavin biosynthesis pathway; riboflavin synthase 1336230 2893572 KLLA0_D15895g Kluyveromyces lactis riboflavin synthase XP_453760.1 1335523 R 28985 CDS KLLA0_D15917g 2892957 complement(1336727..1338262) D 1 NC_006040.1 some similarities with uniprot|P12630 Saccharomyces cerevisiae YIL015W BAR1 Aspartyl protease secreted into the periplasmic space of mating type a cells, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest and to YLR121C uniprot|Q12303 Saccharomyces cerevisiae YLR121C YPS3 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YLR120C uniprot|P32329 Saccharomyces cerevisiae YLR120C YPS1 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YDR144C uniprot|P53379 Saccharomyces cerevisiae YDR144C MKC7 GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p and to YIR039C uniprot|P40583 Saccharomyces cerevisiae YIR039C YPS6 Putative GPI-anchored aspartic protease; aspartyl protease BAR1 1338262 2892957 KLLA0_D15917g Kluyveromyces lactis aspartyl protease BAR1 XP_453761.1 1336727 R 28985 CDS KLLA0_D15939g 2892963 complement(1339006..1339632) D 1 NC_006040.1 weakly similar to YIL016w; uncharacterized protein 1339632 2892963 KLLA0_D15939g Kluyveromyces lactis uncharacterized protein XP_453762.1 1339006 R 28985 CDS KLLA0_D15961g 2892964 1340141..1342984 D 1 NC_006040.1 weakly similar to uniprot|P40547 Saccharomyces cerevisiae YIL017C VID28 Vacuole import and degradation; glucose-induced degradation complex subunit VID28 1342984 2892964 KLLA0_D15961g Kluyveromyces lactis glucose-induced degradation complex subunit VID28 XP_453763.1 1340141 D 28985 CDS KLLA0_D15983g 2893064 1343315..1346422 D 1 NC_006040.1 similar to uniprot|P39692 Saccharomyces cerevisiae YFR030W MET10 Subunit alpha of assimilatory sulfite reductase which is responsible for the conversion of sulfite into sulfide; sulfite reductase subunit alpha 1346422 2893064 KLLA0_D15983g Kluyveromyces lactis sulfite reductase subunit alpha XP_453764.1 1343315 D 28985 CDS KLLA0_D16005g 2893058 complement(1346492..1350004) D 1 NC_006040.1 similar to uniprot|P38989 Saccharomyces cerevisiae YFR031C SMC2 Component of the condensin complex essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase Smc2p/Smc4p complex binds DNA possibly in the cleft formed by the coiled-coil of the folded dimer; condensin subunit SMC2 1350004 2893058 KLLA0_D16005g Kluyveromyces lactis condensin subunit SMC2 XP_453765.1 1346492 R 28985 CDS KLLA0_D16027g 2893593 complement(join(1350451..1351211,1351689..1351692)) D 1 NC_006040.1 highly similar to uniprot|P05736 Saccharomyces cerevisiae YIL018W RPL2B and highly similar to uniprot|P05736 Saccharomyces cerevisiae YFR031C-A RPL2A, Protein component of the large (60S) ribosomal subunit; 60S ribosomal protein uL2 1351692 2893593 KLLA0_D16027g Kluyveromyces lactis 60S ribosomal protein uL2 XP_453766.1 1350451 R 28985 CDS KLLA0_D16049g 2893300 complement(1352380..1353657) D 1 NC_006040.1 some similarities with uniprot|P43607 Saccharomyces cerevisiae YFR032C Hypothetical ORF; uncharacterized protein 1353657 2893300 KLLA0_D16049g Kluyveromyces lactis uncharacterized protein XP_453767.1 1352380 R 28985 CDS KLLA0_D16071g 2893145 complement(1354249..1354437) D 1 NC_006040.1 highly similar to uniprot|P05747 Saccharomyces cerevisiae YFR032C-A RPL29 Protein component of the large (60S) ribosomal subunit; 60S ribosomal protein eL29 1354437 2893145 KLLA0_D16071g Kluyveromyces lactis 60S ribosomal protein eL29 XP_453768.1 1354249 R 28985 CDS KLLA0_D16093g 2893146 complement(1356056..1356424) D 1 NC_006040.1 weakly similar to uniprot|P00127 Saccharomyces cerevisiae YFR033C QCR6 ubiquinol-cytochrome c oxidoreductase subunit 6 (17 kDa); ubiquinol--cytochrome-c reductase subunit 6 1356424 2893146 KLLA0_D16093g Kluyveromyces lactis ubiquinol--cytochrome-c reductase subunit 6 XP_453769.1 1356056 R 28985 CDS KLLA0_D16115g 2893239 complement(1357504..1359573) D 1 NC_006040.1 conserved hypothetical protein; phosphate-sensing transcription factor PHO4 1359573 2893239 KLLA0_D16115g Kluyveromyces lactis phosphate-sensing transcription factor PHO4 XP_453770.1 1357504 R 28985 CDS KLLA0_D16137g 2893274 complement(1360619..1361644) D 1 NC_006040.1 similar to uniprot|P40546 Saccharomyces cerevisiae YIL019W FAF1 Protein required for pre-rRNA processing and 40S ribosomal subunit assembly; uncharacterized protein 1361644 2893274 KLLA0_D16137g Kluyveromyces lactis uncharacterized protein XP_453771.1 1360619 R 28985 CDS KLLA0_D16148g 2893434 1361758..1362561 D 1 NC_006040.1 highly similar to uniprot|P40545 Saccharomyces cerevisiae YIL020C HIS6 Phosphoribosyl-5-amino-1-phosphoribosyl-4- imidazolecarboxiamide isomerase catalyzes the fourth step in histidine biosynthesis mutations cause histidine auxotrophy and sensitivity to Cu Co and Ni salts; 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4- carboxamide isomerase HIS6 1362561 2893434 KLLA0_D16148g Kluyveromyces lactis 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4- carboxamide isomerase HIS6 XP_453772.1 1361758 D 28985 CDS KLLA0_D16170g 2893540 complement(1362809..1363732) D 1 NC_006040.1 highly similar to uniprot|P16370 Saccharomyces cerevisiae YIL021W; DNA-directed RNA polymerase II core subunit RPB3 1363732 2893540 KLLA0_D16170g Kluyveromyces lactis DNA-directed RNA polymerase II core subunit RPB3 XP_453773.1 1362809 R 28985 CDS KLLA0_D16192g 2893541 1364216..1364581 D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 1364581 2893541 KLLA0_D16192g Kluyveromyces lactis uncharacterized protein XP_453774.1 1364216 D 28985 CDS KLLA0_D16214g 2893588 complement(1364989..1366245) D 1 NC_006040.1 highly similar to uniprot|Q01852 Saccharomyces cerevisiae YIL022W TIM44 48.8 kDa protein involved in mitochondrial protein import; protein translocase subunit TIM44 1366245 2893588 KLLA0_D16214g Kluyveromyces lactis protein translocase subunit TIM44 XP_453775.1 1364989 R 28985 CDS KLLA0_D16236g 2892811 complement(1366718..1369333) D 1 NC_006040.1 weakly similar to uniprot|P53278 Saccharomyces cerevisiae YGR130C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; uncharacterized protein 1369333 2892811 KLLA0_D16236g Kluyveromyces lactis uncharacterized protein XP_453776.1 1366718 R 28985 CDS KLLA0_D16280g 2893207 1370792..1371301 D 1 NC_006040.1 similar to uniprot|Q12207 Saccharomyces cerevisiae YPR149W NCE102 and to uniprot|P53279 Saccharomyces cerevisiae YGR131W; uncharacterized protein 1371301 2893207 KLLA0_D16280g Kluyveromyces lactis uncharacterized protein XP_453778.1 1370792 D 28985 CDS KLLA0_D16302g 2893208 complement(1372447..1373127) D 1 NC_006040.1 similar to uniprot|P40961 Saccharomyces cerevisiae YGR132C; prohibitin subunit PHB1 1373127 2893208 KLLA0_D16302g Kluyveromyces lactis prohibitin subunit PHB1 XP_453779.1 1372447 R 28985 CDS KLLA0_D16324g 2892793 complement(1373445..1375538) D 1 NC_006040.1 weakly similar to uniprot|Q7LGV7 Saccharomyces cerevisiae YLR127C; anaphase promoting complex subunit 2 1375538 2892793 KLLA0_D16324g Kluyveromyces lactis anaphase promoting complex subunit 2 XP_453780.1 1373445 R 28985 CDS KLLA0_D16346g 2893229 join(1375653..1375790,1375880..1376647) D 1 NC_006040.1 similar to uniprot|Q12395 Saccharomyces cerevisiae YLR128W DCN1 Hypothetical ORF; NEDD8 ligase DCN1 1376647 2893229 KLLA0_D16346g Kluyveromyces lactis NEDD8 ligase DCN1 XP_453781.1 1375653 D 28985 CDS KLLA0_D16368g 2893453 1376929..1378464 D 1 NC_006040.1 similar to uniprot|Q03761 Saccharomyces cerevisiae YDR145W; uncharacterized protein 1378464 2893453 KLLA0_D16368g Kluyveromyces lactis uncharacterized protein XP_453782.1 1376929 D 28985 CDS KLLA0_D16390g 2892760 1378884..1381694 D 1 NC_006040.1 similar to uniprot|Q12220 Saccharomyces cerevisiae YLR129W DIP2 Nucleolar protein specifically associated with the U3 snoRNA part of the large ribonucleoprotein complex known as the small subunit (SSU) processome required for 18S rRNA biogenesis part of the active pre- rRNA processing complex; snoRNA-binding rRNA-processing protein DIP2 1381694 2892760 KLLA0_D16390g Kluyveromyces lactis snoRNA-binding rRNA-processing protein DIP2 XP_453783.1 1378884 D 28985 CDS KLLA0_D16412g 2892791 complement(1382063..1383652) D 1 NC_006040.1 highly similar to uniprot|P11986 Saccharomyces cerevisiae YJL153C INO1 Inositol 1-phosphate synthase involved in synthesis of inositol phosphates and inositol-containing phospholipids transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p which bind the UASINO DNA element; inositol-3-phosphate synthase INO1 1383652 2892791 KLLA0_D16412g Kluyveromyces lactis inositol-3-phosphate synthase INO1 XP_453784.1 1382063 R 28985 CDS KLLA0_D16434g 2892792 complement(1384826..1386070) D 1 NC_006040.1 similar to uniprot|Q12436 Saccharomyces cerevisiae YLR130C ZRT2 Low-affinity zinc transporter of the plasma membrane transcription is induced under low-zinc conditions by the Zap1p transcription factor; low-affinity Zn(2+) transporter ZRT2 1386070 2892792 KLLA0_D16434g Kluyveromyces lactis low-affinity Zn(2+) transporter ZRT2 XP_453785.1 1384826 R 28985 CDS KLLA0_D16456g 2892945 complement(1387846..1390410) D 1 NC_006040.1 weakly similar to uniprot|P21192 Saccharomyces cerevisiae YLR131C ACE2 Transcription factor that activates expression of early G1-specific genes localizes to daughter cell nuclei after cytokinesis and delays G1 progression in daughters localization is regulated by phosphorylation potential Cdc28p substrate; uncharacterized protein 1390410 2892945 KLLA0_D16456g Kluyveromyces lactis uncharacterized protein XP_453786.1 1387846 R 28985 CDS KLLA0_D16478g 2892902 complement(1391173..1392027) D 1 NC_006040.1 weakly similar to uniprot|Q12208 Saccharomyces cerevisiae YLR132C Protein required for cell viability; phosphoric diester hydrolase 1392027 2892902 KLLA0_D16478g Kluyveromyces lactis phosphoric diester hydrolase XP_453787.1 1391173 R 28985 CDS KLLA0_D16500g 2893120 1392680..1394293 D 1 NC_006040.1 similar to uniprot|P20485 Saccharomyces cerevisiae YLR133W CKI1 choline kinase; uncharacterized protein 1394293 2893120 KLLA0_D16500g Kluyveromyces lactis uncharacterized protein XP_453788.1 1392680 D 28985 CDS KLLA0_D16522g 2893167 complement(1394850..1396256) D 1 NC_006040.1 some similarities with uniprot|P19262 Saccharomyces cerevisiae YDR148C KGD2 Dihydrolipoyl transsuccinylase a component of the mitochondrial alpha-ketoglutarate dehydrogenase complex which catalyzes a step in the tricarboxylic acid (TCA) cycle the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA; dihydrolipoyl transsuccinylase 1396256 2893167 KLLA0_D16522g Kluyveromyces lactis dihydrolipoyl transsuccinylase XP_453789.1 1394850 R 28985 CDS KLLA0_D16544g 2893168 1397378..1399456 D 1 NC_006040.1 weakly similar to uniprot|Q12098 Saccharomyces cerevisiae YLR135W SLX4 Subunit of a complex with Slx1p that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks function overlaps with that of Sgs1p-Top3p; uncharacterized protein 1399456 2893168 KLLA0_D16544g Kluyveromyces lactis uncharacterized protein XP_453790.1 1397378 D 28985 CDS KLLA0_D16566g 2893238 1399913..1407328 D 1 NC_006040.1 weakly similar to uniprot|Q00402 Saccharomyces cerevisiae YDR150W NUM1 Protein required for nuclear migration localizes to the mother cell cortex and the bud tip may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex; uncharacterized protein 1407328 2893238 KLLA0_D16566g Kluyveromyces lactis uncharacterized protein XP_453791.1 1399913 D 28985 CDS KLLA0_D16588g 2893258 1407821..1410103 D 1 NC_006040.1 similar to uniprot|P47161 Saccharomyces cerevisiae YJR126C; uncharacterized protein 1410103 2893258 KLLA0_D16588g Kluyveromyces lactis uncharacterized protein XP_453792.1 1407821 D 28985 CDS KLLA0_D16610g 2893419 complement(1410447..1411379) D 1 NC_006040.1 similar to uniprot|P47976 Saccharomyces cerevisiae YDR151C; uncharacterized protein 1411379 2893419 KLLA0_D16610g Kluyveromyces lactis uncharacterized protein XP_453793.1 1410447 R 28985 CDS KLLA0_D16632g 2893514 1412390..1413193 D 1 NC_006040.1 similar to uniprot|Q03768 Saccharomyces cerevisiae YDR152W GIR2 RWD domain containing protein of unknown function; uncharacterized protein 1413193 2893514 KLLA0_D16632g Kluyveromyces lactis uncharacterized protein XP_453794.1 1412390 D 28985 CDS KLLA0_D16654g 2893515 complement(1413507..1414706) D 1 NC_006040.1 similar to uniprot|Q6Q5U2 Saccharomyces cerevisiae YDR153C ENT5 Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes associates with the clathrin adaptor Gga2p clathrin adaptor complex AP-1 and clathrin; uncharacterized protein 1414706 2893515 KLLA0_D16654g Kluyveromyces lactis uncharacterized protein XP_453795.1 1413507 R 28985 CDS KLLA0_D16676g 2893403 complement(1415185..1415673) D 1 NC_006040.1 highly similar to uniprot|P14832 Saccharomyces cerevisiae YDR155C CPR1 Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues binds the drug cyclosporin A; peptidylprolyl isomerase CPR1 1415673 2893403 KLLA0_D16676g Kluyveromyces lactis peptidylprolyl isomerase CPR1 XP_453796.1 1415185 R 28985 CDS KLLA0_D16709g 2893301 1416147..1416626 D 1 NC_006040.1 similar to uniprot|P50106 Saccharomyces cerevisiae YDR156W RPA14 RNA polymerase I subunit A14; DNA-directed RNA polymerase I subunit RPA14 1416626 2893301 KLLA0_D16709g Kluyveromyces lactis DNA-directed RNA polymerase I subunit RPA14 XP_453798.1 1416147 D 28985 CDS KLLA0_D16731g 2893436 1417095..1418189 D 1 NC_006040.1 highly similar to uniprot|P13663 Saccharomyces cerevisiae YDR158W HOM2 Aspartic beta semi-aldehyde dehydrogenase catalyzes the second step in the common pathway for methionine and threonine biosynthesis expression regulated by Gcn4p and the general control of amino acid synthesis; aspartate-semialdehyde dehydrogenase 1418189 2893436 KLLA0_D16731g Kluyveromyces lactis aspartate-semialdehyde dehydrogenase XP_453799.1 1417095 D 28985 CDS KLLA0_D16753g 2893437 1418383..1419351 D 1 NC_006040.1 similar to uniprot|Q12367 Saccharomyces cerevisiae YLR137W Hypothetical ORF; S-adenosylmethionine-dependent methyltransferase 1419351 2893437 KLLA0_D16753g Kluyveromyces lactis S-adenosylmethionine-dependent methyltransferase XP_453800.1 1418383 D 28985 CDS KLLA0_D16775g 2893464 1419548..1423459 D 1 NC_006040.1 similar to uniprot|P46674 Saccharomyces cerevisiae YDR159W SAC3 Nuclear pore-associated protein forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus; uncharacterized protein 1423459 2893464 KLLA0_D16775g Kluyveromyces lactis uncharacterized protein XP_453801.1 1419548 D 28985 CDS KLLA0_D16797g 2892776 1423833..1426538 D 1 NC_006040.1 similar to uniprot|Q99271 Saccharomyces cerevisiae YLR138W; uncharacterized protein 1426538 2892776 KLLA0_D16797g Kluyveromyces lactis uncharacterized protein XP_453802.1 1423833 D 28985 CDS KLLA0_D16830g 2893188 1426856..1429354 D 1 NC_006040.1 similar to uniprot|Q03770 Saccharomyces cerevisiae YDR160W SSY1 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; uncharacterized protein 1429354 2893188 KLLA0_D16830g Kluyveromyces lactis uncharacterized protein XP_453804.1 1426856 D 28985 CDS KLLA0_D16852g 2893189 1429676..1430800 D 1 NC_006040.1 similar to uniprot|Q03771 Saccharomyces cerevisiae YDR161W interacts with PP2C; uncharacterized protein 1430800 2893189 KLLA0_D16852g Kluyveromyces lactis uncharacterized protein XP_453805.1 1429676 D 28985 CDS KLLA0_D16874g 2892873 complement(1430953..1431636) D 1 NC_006040.1 similar to uniprot|Q12163 Saccharomyces cerevisiae YDR162C NBP2 Protein involved in the HOG (high osmolarity glycerol) pathway negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex found in the nucleus and cytoplasm contains an SH3 domain that binds Pbs2p; uncharacterized protein 1431636 2892873 KLLA0_D16874g Kluyveromyces lactis uncharacterized protein XP_453806.1 1430953 R 28985 CDS KLLA0_D16896g 2892823 1432077..1432640 D 1 NC_006040.1 similar to uniprot|Q03772 Saccharomyces cerevisiae YDR163W CWC15 Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p; U2-type spliceosomal complex subunit CWC15 1432640 2892823 KLLA0_D16896g Kluyveromyces lactis U2-type spliceosomal complex subunit CWC15 XP_453807.1 1432077 D 28985 CDS KLLA0_D16918g 2892794 complement(1432797..1434845) D 1 NC_006040.1 weakly similar to uniprot|P42900 Saccharomyces cerevisiae YLR139C SLS1 Mitochondrial membrane protein required for assembly of respiratory-chain enzyme complexes III and IV coordinates expression of mitochondrially-encoded genes may facilitate delivery of mRNA to membrane-bound translation machinery; uncharacterized protein 1434845 2892794 KLLA0_D16918g Kluyveromyces lactis uncharacterized protein XP_453808.1 1432797 R 28985 CDS KLLA0_D16940g 2892705 1435379..1437001 D 1 NC_006040.1 weakly similar to uniprot|Q02983 Saccharomyces cerevisiae YLR141W RRN5 Transcription factor member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p involved in transcription of rDNA by RNA polymerase I; uncharacterized protein 1437001 2892705 KLLA0_D16940g Kluyveromyces lactis uncharacterized protein XP_453809.1 1435379 D 28985 CDS KLLA0_D16962g 2892706 1437692..1439095 D 1 NC_006040.1 similar to uniprot|P09368 Saccharomyces cerevisiae YLR142W PUT1 proline oxidase; proline dehydrogenase 1439095 2892706 KLLA0_D16962g Kluyveromyces lactis proline dehydrogenase XP_453810.1 1437692 D 28985 CDS KLLA0_D16984g 2892988 1439669..1441759 D 1 NC_006040.1 similar to uniprot|Q07261 Saccharomyces cerevisiae YLR143W Hypothetical ORF; diphthine--ammonia ligase 1441759 2892988 KLLA0_D16984g Kluyveromyces lactis diphthine--ammonia ligase XP_453811.1 1439669 D 28985 CDS KLLA0_D17006g 2892983 1442082..1443092 D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 1443092 2892983 KLLA0_D17006g Kluyveromyces lactis uncharacterized protein XP_453812.1 1442082 D 28985 CDS KLLA0_D17028g 2893142 complement(1443150..1445255) D 1 NC_006040.1 similar to uniprot|P30619 Saccharomyces cerevisiae YDR164C SEC1 Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function; uncharacterized protein 1445255 2893142 KLLA0_D17028g Kluyveromyces lactis uncharacterized protein XP_453813.1 1443150 R 28985 CDS KLLA0_D17050g 2893251 complement(1445796..1448216) D 1 NC_006040.1 similar to uniprot|Q07268 Saccharomyces cerevisiae YLR144C ACF2 Intracellular beta-1 3-endoglucanase expression is induced during sporulation may have a role in cortical actin cytoskeleton assembly; endo-1,3(4)-beta-glucanase 1448216 2893251 KLLA0_D17050g Kluyveromyces lactis endo-1,3(4)-beta-glucanase XP_453814.1 1445796 R 28985 CDS KLLA0_D17072g 2893252 1448823..1449473 D 1 NC_006040.1 weakly similar to uniprot|Q12530 Saccharomyces cerevisiae YLR145W RMP1 Protein required for cell viability component of RNase MRP which is involved in RNA processing in mitochondria; uncharacterized protein 1449473 2893252 KLLA0_D17072g Kluyveromyces lactis uncharacterized protein XP_453815.1 1448823 D 28985 CDS KLLA0_D17094g 2893567 complement(1449542..1450432) D 1 NC_006040.1 similar to uniprot|Q12455 Saccharomyces cerevisiae YLR146C SPE4 Spermine Synthase; spermine synthase 1450432 2893567 KLLA0_D17094g Kluyveromyces lactis spermine synthase XP_453816.1 1449542 R 28985 CDS KLLA0_D17116g 2893560 1451064..1452395 D 1 NC_006040.1 similar to uniprot|Q03774 Saccharomyces cerevisiae YDR165W TRM82 Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA; uncharacterized protein 1452395 2893560 KLLA0_D17116g Kluyveromyces lactis uncharacterized protein XP_453817.1 1451064 D 28985 CDS KLLA0_D17127g 9487305 1452651..1452881 D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 1452881 9487305 KLLA0_D17127g Kluyveromyces lactis uncharacterized protein XP_002999376.1 1452651 D 28985 CDS KLLA0_D17138g 2893552 complement(1452972..1455731) D 1 NC_006040.1 similar to uniprot|P89102 Saccharomyces cerevisiae YDR166C SEC5 Essential 107kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis; exocyst subunit SEC5 1455731 2893552 KLLA0_D17138g Kluyveromyces lactis exocyst subunit SEC5 XP_453818.1 1452972 R 28985 CDS KLLA0_D17160g 2892890 complement(1456067..1456369) D 1 NC_006040.1 similar to uniprot|P43321 Saccharomyces cerevisiae YLR147C SMD3 involved in snRNP biogenesis and pre-mRNA splicing encodes a core snRNP protein; mRNA splicing protein SMD3 1456369 2892890 KLLA0_D17160g Kluyveromyces lactis mRNA splicing protein SMD3 XP_453819.1 1456067 R 28985 CDS KLLA0_D17182g 2892891 1456620..1459394 D 1 NC_006040.1 similar to uniprot|P27801 Saccharomyces cerevisiae YLR148W PEP3 Vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins required for vacuolar biogenesis forms complex with Pep5p that mediates protein transport to the vacuole; tethering complex subunit PEP3 1459394 2892891 KLLA0_D17182g Kluyveromyces lactis tethering complex subunit PEP3 XP_453820.1 1456620 D 28985 CDS KLLA0_D17204g 2892734 1459696..1460274 D 1 NC_006040.1 similar to uniprot|Q12030 Saccharomyces cerevisiae YDR167W TAF10 Subunit (145 kDa) of TFIID and SAGA complexes involved in RNA polymerase II transcription initiation and in chromatin modification; uncharacterized protein 1460274 2892734 KLLA0_D17204g Kluyveromyces lactis uncharacterized protein XP_453821.1 1459696 D 28985 CDS KLLA0_D17226g 2892747 1460573..1462060 D 1 NC_006040.1 similar to uniprot|P06101 Saccharomyces cerevisiae YDR168W CDC37 Essential Hsp90p co-chaperone necessary for passage through the START phase of the cell cycle; uncharacterized protein 1462060 2892747 KLLA0_D17226g Kluyveromyces lactis uncharacterized protein XP_453822.1 1460573 D 28985 CDS KLLA0_D17248g 2892844 complement(1462235..1464274) D 1 NC_006040.1 similar to uniprot|Q99296 Saccharomyces cerevisiae YLR149C Hypothetical ORF; uncharacterized protein 1464274 2892844 KLLA0_D17248g Kluyveromyces lactis uncharacterized protein XP_453823.1 1462235 R 28985 CDS KLLA0_D17270g 2893573 complement(1464854..1466383) D 1 NC_006040.1 weakly similar to uniprot|Q12427 Saccharomyces cerevisiae YDR169C STB3 Protein that binds Sin3p in a two-hybrid assay; uncharacterized protein 1466383 2893573 KLLA0_D17270g Kluyveromyces lactis uncharacterized protein XP_453824.1 1464854 R 28985 CDS KLLA0_D17292g 2893574 complement(1469265..1470254) D 1 NC_006040.1 similar to uniprot|Q12524 Saccharomyces cerevisiae YLR151C PCD1 Peroxisomal nudix pyrophosphatase with specificity for coenzyme A and CoA derivatives may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; 8-oxo-dGTP diphosphatase 1470254 2893574 KLLA0_D17292g Kluyveromyces lactis 8-oxo-dGTP diphosphatase XP_453825.1 1469265 R 28985 CDS KLLA0_D17314g 2893571 complement(1471344..1473182) D 1 NC_006040.1 similar to uniprot|P54072 Saccharomyces cerevisiae YLR152C Hypothetical ORF; uncharacterized protein 1473182 2893571 KLLA0_D17314g Kluyveromyces lactis uncharacterized protein XP_453826.1 1471344 R 28985 CDS KLLA0_D17336g 2893299 complement(1474026..1476080) D 1 NC_006040.1 uniprot|Q9Y7B5 Kluyveromyces lactis KLLA0D17336g ACS2 Acetyl-coenzyme A synthetase 2; acetate--CoA ligase ACS2 1476080 2893299 KLLA0_D17336g Kluyveromyces lactis acetate--CoA ligase ACS2 XP_453827.1 1474026 R 28985 CDS KLLA0_D17358g 2892918 complement(1477523..1483069) D 1 NC_006040.1 similar to uniprot|P11075 Saccharomyces cerevisiae YDR170C SEC7 Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi intra-Golgi transport and ER-to-Golgi transport found in the cytoplasm and on Golgi-associated coated vesicles; Arf family guanine nucleotide exchange factor SEC7 1483069 2892918 KLLA0_D17358g Kluyveromyces lactis Arf family guanine nucleotide exchange factor SEC7 XP_453828.1 1477523 R 28985 CDS KLLA0_D17380g 2892952 1484192..1485490 D 1 NC_006040.1 highly similar to uniprot|Q6YFE5 Saccharomyces kluyveri GTP cyclohydrolase; uncharacterized protein 1485490 2892952 KLLA0_D17380g Kluyveromyces lactis uncharacterized protein XP_453829.1 1484192 D 28985 CDS KLLA0_D17402g 2893044 1485875..1486903 D 1 NC_006040.1 similar to uniprot|P07250 Saccharomyces cerevisiae YDR173C ARG82 Protein involved in regulation of arginine-responsive and Mcm1p-dependent genes has a dual-specificity inositol polyphosphate kinase activity required for regulation of phosphate- and nitrogen- responsive genes; inositol polyphosphate multikinase 1486903 2893044 KLLA0_D17402g Kluyveromyces lactis inositol polyphosphate multikinase XP_453830.1 1485875 D 28985 CDS KLLA0_D17424g 2893045 complement(1486955..1489057) D 1 NC_006040.1 uniprot|Q9HGI8 Kluyveromyces lactis KLLA0D17424g SUP35 Eukaryotic peptide chain release factor GTP-binding subunit; translation termination factor GTPase eRF3 1489057 2893045 KLLA0_D17424g Kluyveromyces lactis translation termination factor GTPase eRF3 XP_453831.1 1486955 R 28985 CDS KLLA0_D17446g 2893127 complement(1489480..1490667) D 1 NC_006040.1 similar to uniprot|Q12329 Saccharomyces cerevisiae YDR171W HSP42 Small cytosolic stress-induced chaperone that forms barrel-shaped oligomers and suppresses the aggregation of non-native proteins oligomer dissociation is not required for function involved in cytoskeleton reorganization after heat shock; heat shock protein HSP42 1490667 2893127 KLLA0_D17446g Kluyveromyces lactis heat shock protein HSP42 XP_453832.1 1489480 R 28985 CDS KLLA0_D17600g 2893415 1495942..1496271 D 1 NC_006040.1 some similarities with uniprot|Q8TGM6 Saccharomyces cerevisiae YLR154W-C TAR1, Mitochondrial protein of unknown function, encoded within the 25S rRNA gene on the opposite strand; uncharacterized protein 1496271 2893415 KLLA0_D17600g Kluyveromyces lactis uncharacterized protein XP_453838.2 1495942 D 28985 CDS KLLA0_D17732g 2893594 1504661..1504990 D 1 NC_006040.1 some similarities with uniprot|Q8TGM6 Saccharomyces cerevisiae YLR154W-C TAR1, Mitochondrial protein of unknown function, encoded within the 25S rRNA gene on the opposite strand; uncharacterized protein 1504990 2893594 KLLA0_D17732g Kluyveromyces lactis uncharacterized protein XP_453844.2 1504661 D 28985 CDS KLLA0_D17864g 2893490 1513372..1513701 D 1 NC_006040.1 some similarities with uniprot|Q8TGM6 Saccharomyces cerevisiae YLR154W-C TAR1, Mitochondrial protein of unknown function, encoded within the 25S rRNA gene on the opposite strand; uncharacterized protein 1513701 2893490 KLLA0_D17864g Kluyveromyces lactis uncharacterized protein XP_453850.1 1513372 D 28985 CDS KLLA0_D17952g 2893492 complement(1516386..1516715) D 1 NC_006040.1 no similarity; uncharacterized protein 1516715 2893492 KLLA0_D17952g Kluyveromyces lactis uncharacterized protein XP_453854.1 1516386 R 28985 CDS KLLA0_D18029g 2893497 join(1521909..1521950,1522143..1522835) D 1 NC_006040.1 similar to uniprot|Q03973 Saccharomyces cerevisiae YDR174W HMO1 Chromatin associated high mobility group (HMG) family member involved in genome maintenance rDNA- binding component of the Pol I transcription system associates with a 5'-3' DNA helicase and Fpr1p a prolyl isomerase; uncharacterized protein 1522835 2893497 KLLA0_D18029g Kluyveromyces lactis uncharacterized protein XP_453858.1 1521909 D 28985 CDS KLLA0_D18051g 2893495 complement(1523490..1524401) D 1 NC_006040.1 similar to uniprot|Q03976 Saccharomyces cerevisiae YDR175C RSM24 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein mS35 1524401 2893495 KLLA0_D18051g Kluyveromyces lactis mitochondrial 37S ribosomal protein mS35 XP_453859.1 1523490 R 28985 CDS KLLA0_D18073g 2893494 1524750..1526666 D 1 NC_006040.1 similar to uniprot|P32494 Saccharomyces cerevisiae YDR176W NGG1 Transcriptional regulator involved in glucose repression of Gal4p-regulated genes component of transcriptional adaptor and histone acetyltransferase complexes the ADA complex the SAGA complex and the SLIK complex; histone acetyltransferase NGG1 1526666 2893494 KLLA0_D18073g Kluyveromyces lactis histone acetyltransferase NGG1 XP_453860.1 1524750 D 28985 CDS KLLA0_D18095g 2893317 complement(1526808..1528217) D 1 NC_006040.1 highly similar to uniprot|P10507 Saccharomyces cerevisiae YLR163C MAS1 Smaller subunit of the mitochondrial processing protease essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins; mitochondrial processing peptidase 1528217 2893317 KLLA0_D18095g Kluyveromyces lactis mitochondrial processing peptidase XP_453861.1 1526808 R 28985 CDS KLLA0_D18117g 2893041 1529251..1529745 D 1 NC_006040.1 similar to uniprot|P37298 Saccharomyces cerevisiae YDR178W SDH4 Membrane anchor subunit of succinate dehydrogenase (Sdh1p Sdh2p Sdh3p Sdh4p) which couples the oxidation of succinate to the transfer of electrons to ubiquinone; uncharacterized protein 1529745 2893041 KLLA0_D18117g Kluyveromyces lactis uncharacterized protein XP_453862.1 1529251 D 28985 CDS KLLA0_D18139g 2893042 complement(1530325..1530801) D 1 NC_006040.1 similar to uniprot|Q03981 Saccharomyces cerevisiae YDR179C CSN9 Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; uncharacterized protein 1530801 2893042 KLLA0_D18139g Kluyveromyces lactis uncharacterized protein XP_453863.1 1530325 R 28985 CDS KLLA0_D18161g 2892841 1531094..1532401 D 1 NC_006040.1 some similarities with uniprot|Q03984 Saccharomyces cerevisiae YDR179W-A Hypothetical ORF; uncharacterized protein 1532401 2892841 KLLA0_D18161g Kluyveromyces lactis uncharacterized protein XP_453864.1 1531094 D 28985 CDS KLLA0_D18172g 2893481 complement(1532328..1533227) D 1 NC_006040.1 similar to uniprot|Q06244 Saccharomyces cerevisiae YLR165C PUS5; uncharacterized protein 1533227 2893481 KLLA0_D18172g Kluyveromyces lactis uncharacterized protein XP_453865.1 1532328 R 28985 CDS KLLA0_D18194g 2893482 1533582..1538024 D 1 NC_006040.1 similar to uniprot|Q04002 Saccharomyces cerevisiae YDR180W SCC2 Sister chromatid cohesion protein; cohesin-loading factor complex subunit SCC2 1538024 2893482 KLLA0_D18194g Kluyveromyces lactis cohesin-loading factor complex subunit SCC2 XP_453866.1 1533582 D 28985 CDS KLLA0_D18216g 2893483 complement(1538132..1539148) D 1 NC_006040.1 weakly similar to uniprot|Q04003 Saccharomyces cerevisiae YDR181c SAS4 involved in silencing at telomere; uncharacterized protein 1539148 2893483 KLLA0_D18216g Kluyveromyces lactis uncharacterized protein XP_453867.1 1538132 R 28985 CDS KLLA0_D18238g 2893478 1539699..1541135 D 1 NC_006040.1 similar to uniprot|P40986 Saccharomyces cerevisiae YDR182W CDC1 Putative membrane protein of unknown function involved in Mn2 homeostasis mutants display actin and general growth defects heterogeneous cell cycle arrests and pleiotropic defects in cell cycle progression and organelle distribution; uncharacterized protein 1541135 2893478 KLLA0_D18238g Kluyveromyces lactis uncharacterized protein XP_453868.1 1539699 D 28985 CDS KLLA0_D18260g 2893479 complement(1541154..1543607) D 1 NC_006040.1 similar to uniprot|Q06245 Saccharomyces cerevisiae YLR166C SEC10 Essential 100kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis; exocyst subunit SEC10 1543607 2893479 KLLA0_D18260g Kluyveromyces lactis exocyst subunit SEC10 XP_453869.1 1541154 R 28985 CDS KLLA0_D18282g 2893480 1544098..1544763 D 1 NC_006040.1 weakly similar to uniprot|Q04004 Saccharomyces cerevisiae YDR183W; uncharacterized protein 1544763 2893480 KLLA0_D18282g Kluyveromyces lactis uncharacterized protein XP_453870.1 1544098 D 28985 CDS KLLA0_D18304g 2893475 1545371..1545823 D 1 NC_006040.1 similar to uniprot|P04838 Saccharomyces cerevisiae YLR167W RPS31 Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; ubiquitin-40S ribosomal protein S31 fusion protein 1545823 2893475 KLLA0_D18304g Kluyveromyces lactis ubiquitin-40S ribosomal protein S31 fusion protein XP_453871.1 1545371 D 28985 CDS KLLA0_D18326g 2893476 complement(1546370..1547221) D 1 NC_006040.1 uniprot|Q6CQB7 Kluyveromyces lactis KLLA0D18326g ATC1 Protein ATC1/LIC4; uncharacterized protein 1547221 2893476 KLLA0_D18326g Kluyveromyces lactis uncharacterized protein XP_453872.1 1546370 R 28985 CDS KLLA0_D18348g 2893477 complement(1548080..1548787) D 1 NC_006040.1 similar to uniprot|P35200 Saccharomyces cerevisiae YLR168C possibly involved in intramitochondrial sorting; uncharacterized protein 1548787 2893477 KLLA0_D18348g Kluyveromyces lactis uncharacterized protein XP_453873.1 1548080 R 28985 CDS KLLA0_D18370g 2893471 complement(1549382..1550449) D 1 NC_006040.1 similar to uniprot|Q6B217 Saccharomyces cerevisiae YLR246W ERF2 Subunit of a palmitoyltransferase composed of Erf2p and Shr5p that adds a palmitoyl lipid moiety to Ras2p through a thioester linkage mutants partially mislocalize Ras2p to the vacuole; palmitoyltransferase ERF2 1550449 2893471 KLLA0_D18370g Kluyveromyces lactis palmitoyltransferase ERF2 XP_453874.1 1549382 R 28985 CDS KLLA0_D18392g 2893472 complement(1550900..1553032) D 1 NC_006040.1 weakly similar to uniprot|Q04007 Saccharomyces cerevisiae YDR186C Hypothetical ORF; uncharacterized protein 1553032 2893472 KLLA0_D18392g Kluyveromyces lactis uncharacterized protein XP_453875.1 1550900 R 28985 CDS KLLA0_D18414g 2893473 1553985..1554428 D 1 NC_006040.1 similar to uniprot|Q06549 Saccharomyces cerevisiae YLR245C CDD1 Cytidine deaminase catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified localizes to both the nucleus and cytoplasm; cytidine deaminase 1554428 2893473 KLLA0_D18414g Kluyveromyces lactis cytidine deaminase XP_453876.1 1553985 D 28985 CDS KLLA0_D18436g 2893474 1554955..1556082 D 1 NC_006040.1 highly similar to uniprot|Q01662 Saccharomyces cerevisiae YLR244C MAP1 Methionine aminopeptidase catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides function is partially redundant with that of Map2p; methionine aminopeptidase MAP1 1556082 2893474 KLLA0_D18436g Kluyveromyces lactis methionine aminopeptidase MAP1 XP_453877.1 1554955 D 28985 CDS KLLA0_D18458g 2893469 1556738..1558372 D 1 NC_006040.1 highly similar to uniprot|P39079 Saccharomyces cerevisiae YDR188W CCT6 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p essential protein that is required for the assembly of actin and tubulins in vivo contains an ATP-binding motif; chaperonin-containing T-complex subunit CCT6 1558372 2893469 KLLA0_D18458g Kluyveromyces lactis chaperonin-containing T-complex subunit CCT6 XP_453878.1 1556738 D 28985 CDS KLLA0_D18480g 2893470 1558735..1560663 D 1 NC_006040.1 similar to uniprot|P22213 Saccharomyces cerevisiae YDR189W SLY1 Hydrophilic protein involved in vesicle trafficking between the ER and Golgi SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex; syntaxin-binding protein 1560663 2893470 KLLA0_D18480g Kluyveromyces lactis syntaxin-binding protein XP_453879.1 1558735 D 28985 CDS KLLA0_D18502g 2893465 complement(1560764..1562137) D 1 NC_006040.1 highly similar to uniprot|Q03940 Saccharomyces cerevisiae YDR190C RVB1 RUVB-like protein TIP49a Homologue; RuvB family ATP-dependent DNA helicase pontin 1562137 2893465 KLLA0_D18502g Kluyveromyces lactis RuvB family ATP-dependent DNA helicase pontin XP_453880.1 1560764 R 28985 CDS KLLA0_D18535g 2893467 1562984..1564183 D 1 NC_006040.1 similar to uniprot|P53688 Saccharomyces cerevisiae YDR191W HST4 Member of the Sir2 family of NAD()-dependent protein deacetylases involved along with Hst3p in silencing at telomeres cell cycle progression radiation resistance genomic stability and short-chain fatty acid metabolism; NAD-dependent histone deacetylase HST4 1564183 2893467 KLLA0_D18535g Kluyveromyces lactis NAD-dependent histone deacetylase HST4 XP_453882.1 1562984 D 28985 CDS KLLA0_D18557g 2893468 complement(1564372..1565277) D 1 NC_006040.1 highly similar to uniprot|Q06543 Saccharomyces cerevisiae YLR243W Protein required for cell viability; uncharacterized protein 1565277 2893468 KLLA0_D18557g Kluyveromyces lactis uncharacterized protein XP_453883.1 1564372 R 28985 CDS KLLA0_D18601g 2893260 1567554..1568462 D 1 NC_006040.1 similar to uniprot|Q2VQX3 Saccharomyces cerevisiae YLR242C; sterol homeostasis protein ARV1 1568462 2893260 KLLA0_D18601g Kluyveromyces lactis sterol homeostasis protein ARV1 XP_453885.1 1567554 D 28985 CDS KLLA0_D18623g 2893261 complement(1568498..1570837) D 1 NC_006040.1 similar to uniprot|Q06538 Saccharomyces cerevisiae YLR241W Hypothetical ORF; uncharacterized protein 1570837 2893261 KLLA0_D18623g Kluyveromyces lactis uncharacterized protein XP_453886.1 1568498 R 28985 CDS KLLA0_D18645g 2893198 complement(1571106..1573694) D 1 NC_006040.1 similar to uniprot|P22543 Saccharomyces cerevisiae YLR240W VPS34 Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; similar to p110 subunit of mammalian PI 3-kinase; phosphatidylinositol 3-kinase VPS34 1573694 2893198 KLLA0_D18645g Kluyveromyces lactis phosphatidylinositol 3-kinase VPS34 XP_453887.1 1571106 R 28985 CDS KLLA0_D18667g 2893113 complement(1574160..1576217) D 1 NC_006040.1 similar to uniprot|P15424 Saccharomyces cerevisiae YDR194C MSS116 DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns presumed RNA helicase due to DEAD-box motif; ATP-dependent RNA helicase 1576217 2893113 KLLA0_D18667g Kluyveromyces lactis ATP-dependent RNA helicase XP_453888.1 1574160 R 28985 CDS KLLA0_D18689g 2893114 1577545..1578942 D 1 NC_006040.1 similar to uniprot|P42073 Saccharomyces cerevisiae YDR195W REF2 RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation also involved in snoRNA maturation; RNA-processing protein REF2 1578942 2893114 KLLA0_D18689g Kluyveromyces lactis RNA-processing protein REF2 XP_453889.1 1577545 D 28985 CDS KLLA0_D18711g 2893115 complement(1579086..1579946) D 1 NC_006040.1 similar to uniprot|Q03941 Saccharomyces cerevisiae YDR196C predicted to catalyze the final step in synthesis of Coenzyme A; uncharacterized protein 1579946 2893115 KLLA0_D18711g Kluyveromyces lactis uncharacterized protein XP_453890.1 1579086 R 28985 CDS KLLA0_D18733g 2893116 1580743..1581855 D 1 NC_006040.1 similar to uniprot|P14905 Saccharomyces cerevisiae YDR197W CBS2 Translational activator of COB mRNA soluble protein cytochrome b translational activator; uncharacterized protein 1581855 2893116 KLLA0_D18733g Kluyveromyces lactis uncharacterized protein XP_453891.1 1580743 D 28985 CDS KLLA0_D18755g 2893106 complement(1581943..1583328) D 1 NC_006040.1 similar to uniprot|Q03942 Saccharomyces cerevisiae YDR198C Hypothetical ORF; protein-lysine N-methyltransferase 1583328 2893106 KLLA0_D18755g Kluyveromyces lactis protein-lysine N-methyltransferase XP_453892.1 1581943 R 28985 CDS KLLA0_D18777g 2892930 1583574..1584572 D 1 NC_006040.1 uniprot|O13476 Kluyveromyces lactis KLLA0D18777g LIPB Lipoate-protein ligase, mitochondrial precursor; lipoyl(octanoyl) transferase LIP2 1584572 2892930 KLLA0_D18777g Kluyveromyces lactis lipoyl(octanoyl) transferase LIP2 XP_453893.1 1583574 D 28985 CDS KLLA0_D18799g 2893107 complement(1584644..1586047) D 1 NC_006040.1 similar to uniprot|Q03944 Saccharomyces cerevisiae YDR200C VPS64; uncharacterized protein 1586047 2893107 KLLA0_D18799g Kluyveromyces lactis uncharacterized protein XP_453894.1 1584644 R 28985 CDS KLLA0_D18821g 2893108 1586393..1586854 D 1 NC_006040.1 similar to uniprot|Q03954 Saccharomyces cerevisiae YDR201W SPC19 Component of Dam1p complex important for spindle and kinetochore integrity localized to nuclear side of spindle pole body and along mitotic spindle; uncharacterized protein 1586854 2893108 KLLA0_D18821g Kluyveromyces lactis uncharacterized protein XP_453895.1 1586393 D 28985 CDS KLLA0_D18843g 2893103 complement(1586889..1587956) D 1 NC_006040.1 similar to uniprot|Q03956 Saccharomyces cerevisiae YDR202C RAV2 Subunit of RAVE (Rav1p Rav2p Skp1p) a complex that associates with the V1 domain of the vacuolar membrane (H)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme; uncharacterized protein 1587956 2893103 KLLA0_D18843g Kluyveromyces lactis uncharacterized protein XP_453896.1 1586889 R 28985 CDS KLLA0_D18865g 2893104 1588334..1589332 D 1 NC_006040.1 similar to uniprot|O13525 Saccharomyces cerevisiae YDR204W COQ4 Protein with a role in ubiquinone (Coenzyme Q) biosynthesis possibly functioning in stabilization of Coq7p located on the matrix face of the mitochondrial inner membrane; ubiquinone biosynthesis protein COQ4 1589332 2893104 KLLA0_D18865g Kluyveromyces lactis ubiquinone biosynthesis protein COQ4 XP_453897.1 1588334 D 28985 CDS KLLA0_D18887g 2893105 1590084..1592333 D 1 NC_006040.1 similar to uniprot|P40164 Saccharomyces cerevisiae YNL201C PSY2 Nuclear protein of unknown function deletion results in sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C deletion is synthetically lethal with a chitin synthase (CHS1) null mutant; uncharacterized protein 1592333 2893105 KLLA0_D18887g Kluyveromyces lactis uncharacterized protein XP_453898.1 1590084 D 28985 CDS KLLA0_D18909g 2892905 complement(1592628..1593500) D 1 NC_006040.1 similar to uniprot|P32573 Saccharomyces cerevisiae YNL202W SPS19 late sporulation specific gene which may function during spore wall formation peroxisomal 2 4-dienoyl-CoA reductase; 2,4-dienoyl-CoA reductase (NADPH) 1593500 2892905 KLLA0_D18909g Kluyveromyces lactis 2,4-dienoyl-CoA reductase (NADPH) XP_453899.1 1592628 R 28985 CDS KLLA0_D18942g 2892907 1594560..1595633 D 1 NC_006040.1 similar to uniprot|P35197 Saccharomyces cerevisiae YDL226C GCS1 ADP-ribosylation factor GTPase activating protein; uncharacterized protein 1595633 2892907 KLLA0_D18942g Kluyveromyces lactis uncharacterized protein XP_453901.1 1594560 D 28985 CDS KLLA0_D18964g 2892813 complement(1595893..1596930) D 1 NC_006040.1 weakly similar to uniprot|Q05521 Saccharomyces cerevisiae YDR284C DPP1 diacylglycerol pyrophosphate phosphatase; uncharacterized protein 1596930 2892813 KLLA0_D18964g Kluyveromyces lactis uncharacterized protein XP_453902.1 1595893 R 28985 CDS KLLA0_D18986g 2892814 1597391..1598770 D 1 NC_006040.1 similar to uniprot|P40161 Saccharomyces cerevisiae YNL206C RTT106 Regulator of Ty1 Transposition - same phenotype as RTT101 - RTT105 disruption causes increase in Ty1 transposition. Isolated from the same screen as the other named RTT genes.; uncharacterized protein 1598770 2892814 KLLA0_D18986g Kluyveromyces lactis uncharacterized protein XP_453903.1 1597391 D 28985 CDS KLLA0_D19008g 2892815 complement(1598807..1600075) D 1 NC_006040.1 highly similar to uniprot|P40160 YNL207W Saccharomyces cerevisiae RIO2 Protein required for cell viability; protein kinase RIO2 1600075 2892815 KLLA0_D19008g Kluyveromyces lactis protein kinase RIO2 XP_453904.1 1598807 R 28985 CDS KLLA0_D19041g 2892865 complement(1600915..1602756) D 1 NC_006040.1 highly similar to uniprot|P40150 Saccharomyces cerevisiae YNL209W SSB2 Ribosome-associated molecular chaperone heat shock protein of HSP70 family proposed to be involved in the folding of newly synthesized polypeptide chains homolog of SSB1; Hsp70 family ATPase SSB2 1602756 2892865 KLLA0_D19041g Kluyveromyces lactis Hsp70 family ATPase SSB2 XP_453906.1 1600915 R 28985 CDS KLLA0_D19063g 2892866 complement(1603523..1604338) D 1 NC_006040.1 weakly similar to uniprot|P16523 Saccharomyces cerevisiae YNL210W MER1 Protein with RNA-binding motifs required for meiosis- specific mRNA splicing; required for chromosome pairing and meiotic recombination; uncharacterized protein 1604338 2892866 KLLA0_D19063g Kluyveromyces lactis uncharacterized protein XP_453907.1 1603523 R 28985 CDS KLLA0_D19118g 2892862 1606789..1609926 D 1 NC_006040.1 similar to uniprot|Q07660 Saccharomyces cerevisiae YDL231C BRE4 Zinc finger protein containing five transmembrane domains null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A a drug which is known to affect intracellular transport; uncharacterized protein 1609926 2892862 KLLA0_D19118g Kluyveromyces lactis uncharacterized protein XP_453910.1 1606789 D 28985 CDS KLLA0_D19129g 9487473 complement(1610176..1610295) D 1 NC_006040.1 highly similar to uniprot|Q99380 Saccharomyces cerevisiae YDL232W OST4 Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; type I membrane protein of 36 residues that binds Stt3p and Ost3p together in a subcomplex; olichyl-diphosphooligosaccharide--protein glycotransferase OST4 1610295 9487473 KLLA0_D19129g Kluyveromyces lactis olichyl-diphosphooligosaccharide--protein glycotransferase OST4 XP_002999377.1 1610176 R 28985 CDS KLLA0_D19140g 2892863 1610589..1610849 D 1 NC_006040.1 similar to uniprot|P53869 Saccharomyces cerevisiae YNL211C Hypothetical ORF; uncharacterized protein 1610849 2892863 KLLA0_D19140g Kluyveromyces lactis uncharacterized protein XP_453911.1 1610589 D 28985 CDS KLLA0_D19162g 2892701 complement(1611324..1612193) D 1 NC_006040.1 some similarities with uniprot|P40157 Saccharomyces cerevisiae YNL212W VID27 Vacuole import and degradation; uncharacterized protein 1612193 2892701 KLLA0_D19162g Kluyveromyces lactis uncharacterized protein XP_453912.1 1611324 R 28985 CDS KLLA0_D19184g 2892702 1613134..1613862 D 1 NC_006040.1 similar to uniprot|P40156 Saccharomyces cerevisiae YNL213C Hypothetical ORF; uncharacterized protein 1613862 2892702 KLLA0_D19184g Kluyveromyces lactis uncharacterized protein XP_453913.1 1613134 D 28985 CDS KLLA0_D19206g 2892703 complement(1614045..1614632) D 1 NC_006040.1 similar to uniprot|P40155 Saccharomyces cerevisiae YNL214W PEX17 Peroxisomal membrane protein component of the peroxisomal translocation machinery required for peroxisome biogenesis binds Pex14p; uncharacterized protein 1614632 2892703 KLLA0_D19206g Kluyveromyces lactis uncharacterized protein XP_453914.1 1614045 R 28985 CDS KLLA0_D19228g 2892831 complement(1615062..1617185) D 1 NC_006040.1 weakly similar to uniprot|Q07684 Saccharomyces cerevisiae YDL233W Hypothetical ORF; uncharacterized protein 1617185 2892831 KLLA0_D19228g Kluyveromyces lactis uncharacterized protein XP_453915.1 1615062 R 28985 CDS KLLA0_D19250g 2892833 complement(1617539..1618561) D 1 NC_006040.1 weakly similar to uniprot|P40154 Saccharomyces cerevisiae YNL215W IES2 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; uncharacterized protein 1618561 2892833 KLLA0_D19250g Kluyveromyces lactis uncharacterized protein XP_453916.1 1617539 R 28985 CDS KLLA0_D19272g 2892834 1618994..1621222 D 1 NC_006040.1 similar to uniprot|P48365 Saccharomyces cerevisiae YDL234C GYP7 GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective) Ypt1p Ypt31p and Ypt32p (in vitro) involved in vesicle mediated protein trafficking; GTPase-activating protein GYP7 1621222 2892834 KLLA0_D19272g Kluyveromyces lactis GTPase-activating protein GYP7 XP_453917.1 1618994 D 28985 CDS KLLA0_D19294g 2892870 complement(1621376..1623376) D 1 NC_006040.1 uniprot|Q01073 Kluyveromyces lactis KLLA0D19294g RAP1 DNA-binding protein; DNA-binding transcription factor RAP1 1623376 2892870 KLLA0_D19294g Kluyveromyces lactis DNA-binding transcription factor RAP1 XP_453918.1 1621376 R 28985 CDS KLLA0_D19316g 2892871 complement(1623976..1624908) D 1 NC_006040.1 similar to uniprot|P40152 Saccharomyces cerevisiae YNL217W Hypothetical ORF; uncharacterized protein 1624908 2892871 KLLA0_D19316g Kluyveromyces lactis uncharacterized protein XP_453919.1 1623976 R 28985 CDS KLLA0_D19338g 2892872 1628572..1628979 D 1 NC_006040.1 similar to uniprot|Q07688 Saccharomyces cerevisiae YDL235C YPD1 Phosphorelay intermediate protein phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus; uncharacterized protein 1628979 2892872 KLLA0_D19338g Kluyveromyces lactis uncharacterized protein XP_453920.1 1628572 D 28985 CDS KLLA0_D19360g 2893504 complement(1629360..1631039) D 1 NC_006040.1 similar to uniprot|P40151 Saccharomyces cerevisiae YNL218W MGS1 Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome interacts functionally with DNA polymerase delta homolog of human Werner helicase interacting protein (WHIP); ssDNA-dependent ATPase MGS1 1631039 2893504 KLLA0_D19360g Kluyveromyces lactis ssDNA-dependent ATPase MGS1 XP_453921.1 1629360 R 28985 CDS KLLA0_D19382g 2893505 complement(1631334..1632263) D 1 NC_006040.1 similar to uniprot|P19881 Saccharomyces cerevisiae YDL236W PHO13 Alkaline phosphatase specific for p-nitrophenyl phosphate involved in dephosphorylation of histone II-A and casein; 4-nitrophenylphosphatase 1632263 2893505 KLLA0_D19382g Kluyveromyces lactis 4-nitrophenylphosphatase XP_453922.1 1631334 R 28985 CDS KLLA0_D19404g 2893506 1632929..1634590 D 1 NC_006040.1 similar to uniprot|P53868 Saccharomyces cerevisiae YNL219C ALG9 catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides mannosyltransferase; dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase 1634590 2893506 KLLA0_D19404g Kluyveromyces lactis dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase XP_453923.1 1632929 D 28985 CDS KLLA0_D19426g 2893507 complement(1634755..1636053) D 1 NC_006040.1 highly similar to uniprot|P80210 Saccharomyces cerevisiae YNL220W ADE12 Adenylosuccinate synthase catalyzes the first committed step in the 'de novo' biosynthesis of adenosine; adenylosuccinate synthase 1636053 2893507 KLLA0_D19426g Kluyveromyces lactis adenylosuccinate synthase XP_453924.1 1634755 R 28985 CDS KLLA0_D19448g 2893443 1637541..1639994 D 1 NC_006040.1 similar to uniprot|P41812 Saccharomyces cerevisiae YNL221C POP1 Subunit of both RNase MRP which cleaves pre-rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends binds to the RPR1 RNA subunit in Rnase P; ribonuclease P/MRP protein subunit POP1 1639994 2893443 KLLA0_D19448g Kluyveromyces lactis ribonuclease P/MRP protein subunit POP1 XP_453925.1 1637541 D 28985 CDS KLLA0_D19470g 2893444 complement(1641182..1642441) D 1 NC_006040.1 weakly similar to uniprot|Q6B312 Saccharomyces cerevisiae YDL237W Hypothetical ORF; uncharacterized protein 1642441 2893444 KLLA0_D19470g Kluyveromyces lactis uncharacterized protein XP_453926.1 1641182 R 28985 CDS KLLA0_D19492g 2893421 1643703..1645193 D 1 NC_006040.1 similar to uniprot|Q07729 Saccharomyces cerevisiae YDL238C GUD1 Guanine deaminase a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures; guanine deaminase 1645193 2893421 KLLA0_D19492g Kluyveromyces lactis guanine deaminase XP_453927.1 1643703 D 28985 CDS KLLA0_D19514g 2893209 complement(1645274..1645897) D 1 NC_006040.1 similar to uniprot|P53538 Saccharomyces cerevisiae YNL222W SSU72 Transcription/RNA-processing factor that associates with TFIIB and cleavage/polyadenylation factor Pta1p exhibits intrinsic phosphatase activity affects start site selection in vivo Nuclear zinc-finger motif containing protein.; RNA polymerase II subunit A C-terminal domain phosphatase 1645897 2893209 KLLA0_D19514g Kluyveromyces lactis RNA polymerase II subunit A C-terminal domain phosphatase XP_453928.1 1645274 R 28985 CDS KLLA0_D19536g 2893210 complement(1646330..1647682) D 1 NC_006040.1 similar to uniprot|P53867 Saccharomyces cerevisiae YNL223W ATG4 Cysteine protease required for autophagy cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation mediates attachment of autophagosomes to microtubules through interactions with Tub1p and Tub2p; cysteine protease ATG4 1647682 2893210 KLLA0_D19536g Kluyveromyces lactis cysteine protease ATG4 XP_453929.1 1646330 R 28985 CDS KLLA0_D19558g 2893211 1647949..1650171 D 1 NC_006040.1 similar to uniprot|P53866 Saccharomyces cerevisiae YNL224C Hypothetical ORF; uncharacterized protein 1650171 2893211 KLLA0_D19558g Kluyveromyces lactis uncharacterized protein XP_453930.1 1647949 D 28985 CDS KLLA0_D19580g 2893212 1650584..1652848 D 1 NC_006040.1 weakly similar to uniprot|Q07732 Saccharomyces cerevisiae YDL239C ADY3 Protein required for spore wall formation thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components potentially phosphorylated by Cdc28p; uncharacterized protein 1652848 2893212 KLLA0_D19580g Kluyveromyces lactis uncharacterized protein XP_453931.1 1650584 D 28985 CDS KLLA0_D19602g 2893110 1653096..1654958 D 1 NC_006040.1 similar to uniprot|P53863 Saccharomyces cerevisiae YNL227C JJJ1 Protein that may function as a cochaperone as suggested by the presence of a DnaJ-like domain; uncharacterized protein 1654958 2893110 KLLA0_D19602g Kluyveromyces lactis uncharacterized protein XP_453932.1 1653096 D 28985 CDS KLLA0_D19624g 2893111 1655546..1656715 D 1 NC_006040.1 uniprot|Q96X43 Kluyveromyces lactis Ure2p; glutathione peroxidase 1656715 2893111 KLLA0_D19624g Kluyveromyces lactis glutathione peroxidase XP_453933.1 1655546 D 28985 CDS KLLA0_D19646g 2893112 1657122..1658066 D 1 NC_006040.1 weakly similar to uniprot|P53861 Saccharomyces cerevisiae YNL230C ELA1 Elongin A F-box protein that forms a heterodimer with Elc1p and participates in transcription elongation; elongin A 1658066 2893112 KLLA0_D19646g Kluyveromyces lactis elongin A XP_453934.1 1657122 D 28985 CDS KLLA0_D19701g 2893097 complement(1660119..1661012) D 1 NC_006040.1 similar to uniprot|P53859 Saccharomyces cerevisiae YNL232W CSL4 Subunit of the exosome which is an essential complex present in both nucleus and cytoplasm that mediates RNA processing and degradation; exosome non-catalytic core subunit CSL4 1661012 2893097 KLLA0_D19701g Kluyveromyces lactis exosome non-catalytic core subunit CSL4 XP_453937.1 1660119 R 28985 CDS KLLA0_D19723g 2893098 complement(1661329..1663800) D 1 NC_006040.1 similar to uniprot|P53858 Saccharomyces cerevisiae YNL233W BNI4 Targeting subunit for Glc7p protein phosphatase localized to the bud neck required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p; uncharacterized protein 1663800 2893098 KLLA0_D19723g Kluyveromyces lactis uncharacterized protein XP_453938.1 1661329 R 28985 CDS KLLA0_D19745g 2893092 complement(1664368..1665660) D 1 NC_006040.1 similar to uniprot|Q75E71 Ashbya gossypii ABL201W ABL201Wp and some similarites with YNL234W uniprot|P53857 Saccharomyces cerevisiae YNL234W Similar to globins and has a functional heme-binding domain involved in glucose signaling or metabolism regulated by Rgt1p; uncharacterized protein 1665660 2893092 KLLA0_D19745g Kluyveromyces lactis uncharacterized protein XP_453939.1 1664368 R 28985 CDS KLLA0_D19767g 2893093 complement(1667231..1670101) D 1 NC_006040.1 similar to uniprot|P32259 YNL236W Saccharomyces cerevisiae SIN4 involved in positive and negative regulation of transcription; uncharacterized protein 1670101 2893093 KLLA0_D19767g Kluyveromyces lactis uncharacterized protein XP_453940.1 1667231 R 28985 CDS KLLA0_D19789g 2893305 complement(1670586..1671872) D 1 NC_006040.1 similar to uniprot|P53584 Saccharomyces cerevisiae YNL237W; uncharacterized protein 1671872 2893305 KLLA0_D19789g Kluyveromyces lactis uncharacterized protein XP_453941.1 1670586 R 28985 CDS KLLA0_D19811g 2893281 complement(1672338..1674608) D 1 NC_006040.1 uniprot|P09231 Kluyveromyces lactis KLLA0D19811g KEX1 protease precursor; kexin KEX2 1674608 2893281 KLLA0_D19811g Kluyveromyces lactis kexin KEX2 XP_453942.1 1672338 R 28985 CDS KLLA0_D19833g 2892895 1675407..1676816 D 1 NC_006040.1 uniprot|P53998 Kluyveromyces lactis LET1 PROTEIN; iron-sulfur cluster assembly protein NAR1 1676816 2892895 KLLA0_D19833g Kluyveromyces lactis iron-sulfur cluster assembly protein NAR1 XP_453943.1 1675407 D 28985 CDS KLLA0_D19855g 2893289 1678342..1679835 D 1 NC_006040.1 uniprot|P48828 Kluyveromyces lactis G6PD ZWF Glucose-6- phosphate 1-dehydrogenase; glucose-6-phosphate dehydrogenase 1679835 2893289 KLLA0_D19855g Kluyveromyces lactis glucose-6-phosphate dehydrogenase XP_453944.1 1678342 D 28985 CDS KLLA0_D19877g 2893306 complement(1680043..1683015) D 1 NC_006040.1 similar to uniprot|P35688 Saccharomyces cerevisiae YDL240W LRG1 Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity appears to specifically regulate 1 3-beta-glucan synthesis; GTPase-activating protein LRG1 1683015 2893306 KLLA0_D19877g Kluyveromyces lactis GTPase-activating protein LRG1 XP_453945.1 1680043 R 28985 CDS KLLA0_D19899g 2893307 complement(1683427..1687935) D 1 NC_006040.1 similar to uniprot|P53855 YNL242W Saccharomyces cerevisiae ATG2 Peripheral membrane protein required for the formation of cytosolic sequestering vesicles involved in vacuolar import through both the Cvt pathway and autophagy; uncharacterized protein 1687935 2893307 KLLA0_D19899g Kluyveromyces lactis uncharacterized protein XP_453946.1 1683427 R 28985 CDS KLLA0_D19921g 2893308 1690012..1690863 D 1 NC_006040.1 similar to uniprot|Q12512 Saccharomyces cerevisiae YOL154W ZPS1 Putative GPI-anchored protein transcription is induced under low-zinc conditions as mediated by the Zap1p transcription factor and at alkaline pH; uncharacterized protein 1690863 2893308 KLLA0_D19921g Kluyveromyces lactis uncharacterized protein XP_453947.1 1690012 D 28985 CDS KLLA0_D19929g 9487304 1694826..1695986 D 1 NC_006040.1 weakly similar to uniprot|P35497 Saccharomyces cerevisiae YJR159W SOR1 Sorbitol dehydrogenase; uncharacterized protein 1695986 9487304 KLLA0_D19929g Kluyveromyces lactis uncharacterized protein XP_002999378.1 1694826 D 28985 CDS KLLA0_D19933g 9487393 complement(1696360..1697166) D 1 NC_006040.1 weakly similar to uniprot|Q05016 Saccharomyces cerevisiae YMR226C NADP(+)-dependent dehydrogenase; uncharacterized protein 1697166 9487393 KLLA0_D19933g Kluyveromyces lactis uncharacterized protein XP_002999379.1 1696360 R 28985 CDS KLLA0_D19941g 9487317 complement(1698889..1700724) D 1 NC_006040.1 similar to uniprot|P36172 Saccharomyces cerevisiae YKR105C Hypothetical ORF; uncharacterized protein 1700724 9487317 KLLA0_D19941g Kluyveromyces lactis uncharacterized protein XP_002999380.1 1698889 R 28985 CDS KLLA0_D19945g 9487398 1701681..1703615 D 1 NC_006040.1 similar to uniprot|P36173 Saccharomyces cerevisiae YKR106W; uncharacterized protein 1703615 9487398 KLLA0_D19945g Kluyveromyces lactis uncharacterized protein XP_002999381.1 1701681 D 28985 CDS KLLA0_D19949g 9487494 complement(1703696..1704247) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 1704247 9487494 KLLA0_D19949g Kluyveromyces lactis uncharacterized protein XP_002999382.1 1703696 R 28985 CDS KLLA0_D19953g 9487329 complement(1704481..1705842) D 1 NC_006040.1 similar to uniprot|P53048 Saccharomyces cerevisiae YGR289C MAL11 Maltose permease inducible high-affinity maltose transporter (alpha-glucoside transporter) encoded in the MAL1 complex locus member of the 12 transmembrane domain superfamily of sugar transporters; uncharacterized protein 1705842 9487329 KLLA0_D19953g Kluyveromyces lactis uncharacterized protein XP_002999383.1 1704481 R 28985 CDS KLLA0_D19957g 9487411 1705967..1706491 D 1 NC_006040.1 some similarities with uniprot|Q08295 Saccharomyces cerevisiae YOL157C Hypothetical ORF; uncharacterized protein 1706491 9487411 KLLA0_D19957g Kluyveromyces lactis uncharacterized protein XP_002999384.1 1705967 D 28985 CDS KLLA0_D19965g 2893303 complement(1706982..1707422) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 1707422 2893303 KLLA0_D19965g Kluyveromyces lactis uncharacterized protein XP_453949.2 1706982 R 28985 CDS KLLA0_D19987g 2893304 1708507..1708974 D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 1708974 2893304 KLLA0_D19987g Kluyveromyces lactis uncharacterized protein XP_453950.2 1708507 D 28985 CDS KLLA0_D20009g 2893297 complement(1709412..1710935) D 1 NC_006040.1 similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport; uncharacterized protein 1710935 2893297 KLLA0_D20009g Kluyveromyces lactis uncharacterized protein XP_453951.1 1709412 R 28985 CDS KLLA0_D20031g 2893298 complement(1711728..1712774) D 1 NC_006040.1 conserved hypothetical protein; uncharacterized protein 1712774 2893298 KLLA0_D20031g Kluyveromyces lactis uncharacterized protein XP_453952.2 1711728 R 28985 CDS KLLA0_E00111g 2894259 2681..3727 E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 3727 2894259 KLLA0_E00111g Kluyveromyces lactis uncharacterized protein XP_453953.1 2681 D 28985 CDS KLLA0_E00133g 2894148 4528..6051 E 1 NC_006041.1 similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport; uncharacterized protein 6051 2894148 KLLA0_E00133g Kluyveromyces lactis uncharacterized protein XP_453954.1 4528 D 28985 CDS KLLA0_E00155g 9487526 complement(6738..6956) E 1 NC_006041.1 no similarity; uncharacterized protein 6956 9487526 KLLA0_E00155g Kluyveromyces lactis uncharacterized protein XP_002999385.1 6738 R 28985 CDS KLLA0_E00177g 2894039 8041..8481 E 1 NC_006041.1 no similarity; uncharacterized protein 8481 2894039 KLLA0_E00177g Kluyveromyces lactis uncharacterized protein XP_453955.1 8041 D 28985 CDS KLLA0_E00221g 2893994 9200..10468 E 1 NC_006041.1 similar to uniprot|Q06598 Saccharomyces cerevisiae YPR201W ARR3 Arsenite transporter of the plasma membrane required for resistance to arsenic compounds transcription is activated by Arr1p in the presence of arsenite; uncharacterized protein 10468 2893994 KLLA0_E00221g Kluyveromyces lactis uncharacterized protein XP_453956.1 9200 D 28985 CDS KLLA0_E00243g 2893758 11467..11862 E 1 NC_006041.1 similar to uniprot|Q06597 YPR200C Saccharomyces cerevisiae ARR2 Arsenate reductase required for arsenate resistance; uncharacterized protein 11862 2893758 KLLA0_E00243g Kluyveromyces lactis uncharacterized protein XP_453957.1 11467 D 28985 CDS KLLA0_E00265g 2894732 12033..12899 E 1 NC_006041.1 weakly similar to uniprot|Q06596 Saccharomyces cerevisiae YPR199C ARR1 Transcriptional activator of the bZIP family required for transcription of genes involved in resistance to arsenic compounds; uncharacterized protein 12899 2894732 KLLA0_E00265g Kluyveromyces lactis uncharacterized protein XP_453958.1 12033 D 28985 CDS KLLA0_E00287g 2894260 15302..16837 E 1 NC_006041.1 weakly similar to uniprot|P23585 Saccharomyces cerevisiae YMR011W HXT2 High-affinity glucose transporter of the major facilitator superfamily; uncharacterized protein 16837 2894260 KLLA0_E00287g Kluyveromyces lactis uncharacterized protein XP_453960.1 15302 D 28985 CDS KLLA0_E00309g 2894062 17100..18608 E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 18608 2894062 KLLA0_E00309g Kluyveromyces lactis uncharacterized protein XP_453961.1 17100 D 28985 CDS KLLA0_E00397g 2894061 23256..25637 E 1 NC_006041.1 highly similar to uniprot|P40897 Saccharomyces cerevisiae YJL212C OPT1 Plasma membrane transporter that transports tetra- and pentapeptides and glutathione member of the OPT family; oligopeptide transporter OPT1 25637 2894061 KLLA0_E00397g Kluyveromyces lactis oligopeptide transporter OPT1 XP_453962.1 23256 D 28985 CDS KLLA0_E00419g 2893724 28957..31341 E 1 NC_006041.1 similar to uniprot|P40897 Saccharomyces cerevisiae YJL212C OPT1 Plasma membrane transporter that transports tetra- and pentapeptides and glutathione member of the OPT family; uncharacterized protein 31341 2893724 KLLA0_E00419g Kluyveromyces lactis uncharacterized protein XP_453963.1 28957 D 28985 CDS KLLA0_E00441g 2894596 32524..34200 E 1 NC_006041.1 similar to uniprot|P38732 Saccharomyces cerevisiae YHL039W Hypothetical ORF; protein-lysine N-methyltransferase 34200 2894596 KLLA0_E00441g Kluyveromyces lactis protein-lysine N-methyltransferase XP_453965.1 32524 D 28985 CDS KLLA0_E00463g 2894462 complement(join(34713..35130,35651..35664)) E 1 NC_006041.1 highly similar to uniprot|Q03048 Saccharomyces cerevisiae YLL050C COF1 yeast cortical cytoskeleton component mammalian cofilin homolog Cofilin actin binding and severing protein; cofilin 35664 2894462 KLLA0_E00463g Kluyveromyces lactis cofilin XP_453967.1 34713 R 28985 CDS KLLA0_E00485g 2894057 36083..36628 E 1 NC_006041.1 no similarity; uncharacterized protein 36628 2894057 KLLA0_E00485g Kluyveromyces lactis uncharacterized protein XP_453968.1 36083 D 28985 CDS KLLA0_E00507g 2894463 37469..39076 E 1 NC_006041.1 similar to uniprot|P38734 Saccharomyces cerevisiae YHL036W MUP3 Low affinity methionine permease, similar to Mup1p; uncharacterized protein 39076 2894463 KLLA0_E00507g Kluyveromyces lactis uncharacterized protein XP_453969.1 37469 D 28985 CDS KLLA0_E00529g 2894005 complement(39173..44125) E 1 NC_006041.1 similar to uniprot|P32386 Saccharomyces cerevisiae YLL048C; uncharacterized protein 44125 2894005 KLLA0_E00529g Kluyveromyces lactis uncharacterized protein XP_453970.1 39173 R 28985 CDS KLLA0_E00551g 2893905 complement(45755..46483) E 1 NC_006041.1 similar to uniprot|P10080 Saccharomyces cerevisiae YHL034C SBP1 Single-strand nucleic acid binding protein; uncharacterized protein 46483 2893905 KLLA0_E00551g Kluyveromyces lactis uncharacterized protein XP_453971.1 45755 R 28985 CDS KLLA0_E00573g 9487429 complement(47961..48728) E 1 NC_006041.1 highly similar to uniprot|P29453 Saccharomyces cerevisiae RPL8B and to YHL033C uniprot|P17076 Saccharomyces cerevisiae RPL8A Ribosomal protein L4 of the large (60S) ribosomal subunit; 60S ribosomal protein eL8 48728 9487429 KLLA0_E00573g Kluyveromyces lactis 60S ribosomal protein eL8 XP_002999386.1 47961 R 28985 CDS KLLA0_E00595g 2893659 complement(49243..51228) E 1 NC_006041.1 similar to uniprot|P32190 Saccharomyces cerevisiae YHL032C GUT1 Glycerol kinase converts glycerol to glycerol-3-phosphate glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p; glycerol kinase 51228 2893659 KLLA0_E00595g Kluyveromyces lactis glycerol kinase XP_453973.1 49243 R 28985 CDS KLLA0_E00617g 2894219 53103..54794 E 1 NC_006041.1 weakly similar to uniprot|P23900 Saccharomyces cerevisiae YLL043W FPS1 Plasma membrane glycerol channel member of the major intrinsic protein (MIP) family of channel proteins involved in efflux of glycerol and in uptake of the trivalent metalloids arsenite and antimonite; uncharacterized protein 54794 2894219 KLLA0_E00617g Kluyveromyces lactis uncharacterized protein XP_453974.1 53103 D 28985 CDS KLLA0_E00639g 2894015 complement(54895..55542) E 1 NC_006041.1 similar to uniprot|P38736 Saccharomyces cerevisiae YHL031C GOS1 v-SNARE protein involved in Golgi transport homolog of the mammalian protein GOS-28/GS28; uncharacterized protein 55542 2894015 KLLA0_E00639g Kluyveromyces lactis uncharacterized protein XP_453975.1 54895 R 28985 CDS KLLA0_E00661g 2894715 complement(55858..56325) E 1 NC_006041.1 weakly similar to uniprot|Q07879 Saccharomyces cerevisiae YLL042C ATG10 Enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy; uncharacterized protein 56325 2894715 KLLA0_E00661g Kluyveromyces lactis uncharacterized protein XP_453976.1 55858 R 28985 CDS KLLA0_E00683g 2893808 complement(57323..58087) E 1 NC_006041.1 highly similar to uniprot|P21801 Saccharomyces cerevisiae YLL041C SDH2 Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p Sdh2p Sdh3p Sdh4p) which couples the oxidation of succinate to the transfer of electrons to ubiquinone; succinate dehydrogenase iron-sulfur protein subunit SDH2 58087 2893808 KLLA0_E00683g Kluyveromyces lactis succinate dehydrogenase iron-sulfur protein subunit SDH2 XP_453977.1 57323 R 28985 CDS KLLA0_E00705g 2893787 complement(59404..68778) E 1 NC_006041.1 similar to uniprot|Q07878 Saccharomyces cerevisiae YLL040C VPS13 homologous to human COH1 component of peripheral vacuolar membrane protein complex; membrane morphogenesis protein VPS13 68778 2893787 KLLA0_E00705g Kluyveromyces lactis membrane morphogenesis protein VPS13 XP_453978.1 59404 R 28985 CDS KLLA0_E00727g 2893881 69141..74684 E 1 NC_006041.1 similar to uniprot|P38737 Saccharomyces cerevisiae YHL030W ECM29 Major component of the proteasome tethers the proteasome core particle to the regulatory particle and enhances the stability of the proteasome; uncharacterized protein 74684 2893881 KLLA0_E00727g Kluyveromyces lactis uncharacterized protein XP_453979.1 69141 D 28985 CDS KLLA0_E00749g 2893864 complement(74948..76093) E 1 NC_006041.1 highly similar to uniprot|P04838 Saccharomyces cerevisiae YLL039c UBI4 ubiquitin; ubiquitin 76093 2893864 KLLA0_E00749g Kluyveromyces lactis ubiquitin XP_453980.1 74948 R 28985 CDS KLLA0_E00771g 2894762 78021..79361 E 1 NC_006041.1 some similarities with uniprot|P38739 Saccharomyces cerevisiae YHL028W WSC4 cell wall integrity and stress response component 4 Putative integral membrane protein containing novel cysteine motif. Similarity to SLG1 (WSC1) WSC2 and WSC3; uncharacterized protein 79361 2894762 KLLA0_E00771g Kluyveromyces lactis uncharacterized protein XP_453981.1 78021 D 28985 CDS KLLA0_E00793g 2894720 80516..82069 E 1 NC_006041.1 weakly similar to uniprot|P33400 Saccharomyces cerevisiae YHL027W; alkaline-responsive transcriptional regulator RIM101 82069 2894720 KLLA0_E00793g Kluyveromyces lactis alkaline-responsive transcriptional regulator RIM101 XP_453982.1 80516 D 28985 CDS KLLA0_E00815g 2894158 82495..84390 E 1 NC_006041.1 similar to uniprot|Q9P4W6 Saccharomyces cerevisiae YLL035W GRC3 Protein of unknown function required for cell growth and possibly involved in rRNA processing mRNA is cell cycle regulated; polynucleotide 5'-hydroxyl-kinase 84390 2894158 KLLA0_E00815g Kluyveromyces lactis polynucleotide 5'-hydroxyl-kinase XP_453983.1 82495 D 28985 CDS KLLA0_E00837g 2894721 complement(84426..86870) E 1 NC_006041.1 highly similar to uniprot|Q07844 Saccharomyces cerevisiae YLL034C RIX7 Putative ATPase of the AAA family required for export of pre-ribosomal large subunits from the nucleus distributed between the nucleolus nucleoplasm and nuclear periphery depending on growth conditions; uncharacterized protein 86870 2894721 KLLA0_E00837g Kluyveromyces lactis uncharacterized protein XP_453984.1 84426 R 28985 CDS KLLA0_E00859g 2894001 87256..87822 E 1 NC_006041.1 weakly similar to uniprot|Q07843 Saccharomyces cerevisiae YLL033W; uncharacterized protein 87822 2894001 KLLA0_E00859g Kluyveromyces lactis uncharacterized protein XP_453987.1 87256 D 28985 CDS KLLA0_E00881g 2893990 complement(87991..90132) E 1 NC_006041.1 weakly similar to uniprot|Q07834 Saccharomyces cerevisiae YLL032C Hypothetical ORF; uncharacterized protein 90132 2893990 KLLA0_E00881g Kluyveromyces lactis uncharacterized protein XP_453988.1 87991 R 28985 CDS KLLA0_E00903g 2894690 92292..98297 E 1 NC_006041.1 similar to uniprot|P39960 Saccharomyces cerevisiae YER155C BEM2 Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis required for bud emergence; GTPase-activating protein BEM2 98297 2894690 KLLA0_E00903g Kluyveromyces lactis GTPase-activating protein BEM2 XP_453989.1 92292 D 28985 CDS KLLA0_E00925g 2894207 complement(98423..99586) E 1 NC_006041.1 similar to uniprot|P39952 Saccharomyces cerevisiae YER154W OXA1 Translocase of the mitochondrial inner membrane mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane interacts with mitochondrial ribosomes null is respiratory deficient; membrane insertase OXA1 99586 2894207 KLLA0_E00925g Kluyveromyces lactis membrane insertase OXA1 XP_453990.1 98423 R 28985 CDS KLLA0_E00947g 2894180 100123..100968 E 1 NC_006041.1 similar to uniprot|P10355 Saccharomyces cerevisiae YER153C translational activator of cytochrome C oxidase subunit III; uncharacterized protein 100968 2894180 KLLA0_E00947g Kluyveromyces lactis uncharacterized protein XP_453991.1 100123 D 28985 CDS KLLA0_E00969g 2894538 101430..102767 E 1 NC_006041.1 similar to uniprot|P10356 Saccharomyces cerevisiae YER152C Hypothetical ORF; 2-aminoadipate transaminase 102767 2894538 KLLA0_E00969g Kluyveromyces lactis 2-aminoadipate transaminase XP_453992.1 101430 D 28985 CDS KLLA0_E00991g 9487321 103562..104317 E 1 NC_006041.1 similar to uniprot|P38957 Saccharomyces cerevisiae YDR078C SHU2 Suppressor of hydroxy-urea sensitivity; uncharacterized protein 104317 9487321 KLLA0_E00991g Kluyveromyces lactis uncharacterized protein XP_002999387.1 103562 D 28985 CDS KLLA0_E01013g 2894763 104991..107315 E 1 NC_006041.1 some similarities with uniprot|Q01477 Saccharomyces cerevisiae YER151C UBP3 Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments inhibitor of gene silencing cleaves ubiquitin fusions but not polyubiquitin; mRNA-binding ubiquitin-specific protease UBP3 107315 2894763 KLLA0_E01013g Kluyveromyces lactis mRNA-binding ubiquitin-specific protease UBP3 XP_453994.1 104991 D 28985 CDS KLLA0_E01035g 2894208 109821..115457 E 1 NC_006041.1 some similarities with uniprot|P08640 Saccharomyces cerevisiae YIR019C MUC1 GPI-anchored cell surface glycoprotein required for diploid pseudohyphal formation and haploid invasive growth transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p); uncharacterized protein 115457 2894208 KLLA0_E01035g Kluyveromyces lactis uncharacterized protein XP_453995.1 109821 D 28985 CDS KLLA0_E01057g 2893936 complement(116315..116800) E 1 NC_006041.1 some similarities with uniprot|Q01589 Saccharomyces cerevisiae YDR077w SED1 abundant cell surface glycoprotein; uncharacterized protein 116800 2893936 KLLA0_E01057g Kluyveromyces lactis uncharacterized protein XP_453996.1 116315 R 28985 CDS KLLA0_E01079g 2893655 complement(117963..119204) E 1 NC_006041.1 some similarities with uniprot|P38953 Saccharomyces cerevisiae YDR076W RAD55 Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis forms heterodimer with Rad57p; uncharacterized protein 119204 2893655 KLLA0_E01079g Kluyveromyces lactis uncharacterized protein XP_453997.1 117963 R 28985 CDS KLLA0_E01101g 2893756 119812..120573 E 1 NC_006041.1 similar to uniprot|P47141 Saccharomyces cerevisiae YJR101W RSM26 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein mS42 120573 2893756 KLLA0_E01101g Kluyveromyces lactis mitochondrial 37S ribosomal protein mS42 XP_453998.1 119812 D 28985 CDS KLLA0_E01145g 2894202 complement(121191..122633) E 1 NC_006041.1 highly similar to uniprot|P32915 Saccharomyces cerevisiae YLR378C SEC61 Essential subunit of Sec61 complex (Sec61p Sbh1p and Sss1p) forms a channel for SRP- dependent protein import and retrograde transport of misfolded proteins out of the ER with Sec63 complex allows SRP-independent protein import into ER; translocon subunit SEC61 122633 2894202 KLLA0_E01145g Kluyveromyces lactis translocon subunit SEC61 XP_454000.1 121191 R 28985 CDS KLLA0_E01167g 2894187 complement(123073..124512) E 1 NC_006041.1 similar to uniprot|Q07376 Saccharomyces cerevisiae YDL054C; uncharacterized protein 124512 2894187 KLLA0_E01167g Kluyveromyces lactis uncharacterized protein XP_454001.1 123073 R 28985 CDS KLLA0_E01189g 2894027 complement(124802..125227) E 1 NC_006041.1 some similarities with uniprot|Q07362 Saccharomyces cerevisiae YDL053C PBP4 Pbp1p binding protein, interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; uncharacterized protein 125227 2894027 KLLA0_E01189g Kluyveromyces lactis uncharacterized protein XP_454002.1 124802 R 28985 CDS KLLA0_E01211g 2894286 126280..127347 E 1 NC_006041.1 highly similar to uniprot|P09201 Saccharomyces cerevisiae YLR377C FBP1 Fructose-1 6-bisphosphatase key regulatory enzyme in the gluconeogenesis pathway required for glucose metabolism; fructose 1,6-bisphosphate 1-phosphatase 127347 2894286 KLLA0_E01211g Kluyveromyces lactis fructose 1,6-bisphosphate 1-phosphatase XP_454003.1 126280 D 28985 CDS KLLA0_E01233g 2894496 complement(127544..128491) E 1 NC_006041.1 similar to uniprot|P33333 Saccharomyces cerevisiae YDL052C SLC1 fatty acyltransferase; 1-acylglycerol-3-phosphate O-acyltransferase SLC1 128491 2894496 KLLA0_E01233g Kluyveromyces lactis 1-acylglycerol-3-phosphate O-acyltransferase SLC1 XP_454004.1 127544 R 28985 CDS KLLA0_E01255g 2894731 128932..129558 E 1 NC_006041.1 weakly similar to uniprot|Q12318 Saccharomyces cerevisiae YLR376C; uncharacterized protein 129558 2894731 KLLA0_E01255g Kluyveromyces lactis uncharacterized protein XP_454005.1 128932 D 28985 CDS KLLA0_E01277g 2894520 129929..130729 E 1 NC_006041.1 similar to uniprot|P33399 Saccharomyces cerevisiae YDL051W LHP1 RNA binding protein; uncharacterized protein 130729 2894520 KLLA0_E01277g Kluyveromyces lactis uncharacterized protein XP_454006.1 129929 D 28985 CDS KLLA0_E01299g 2894461 complement(130994..131779) E 1 NC_006041.1 similar to uniprot|P39005 Saccharomyces cerevisiae YJL174W KRE9 Glycoprotein involved in cell wall beta-glucan assembly null mutation leads to severe growth defects aberrant multibudded morphology and mating defects; uncharacterized protein 131779 2894461 KLLA0_E01299g Kluyveromyces lactis uncharacterized protein XP_454007.1 130994 R 28985 CDS KLLA0_E01321g 2893766 132673..134538 E 1 NC_006041.1 some similarities with uniprot|Q03795 Saccharomyces cerevisiae YMR155W Hypothetical ORF; uncharacterized protein 134538 2893766 KLLA0_E01321g Kluyveromyces lactis uncharacterized protein XP_454008.1 132673 D 28985 CDS KLLA0_E01343g 2893863 complement(134691..137207) E 1 NC_006041.1 similar to uniprot|P33775 Saccharomyces cerevisiae YDL095W PMT1 Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway acts in complex with Pmt2p dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase; dolichyl-phosphate-mannose-protein mannosyltransferase PMT1 137207 2893863 KLLA0_E01343g Kluyveromyces lactis dolichyl-phosphate-mannose-protein mannosyltransferase PMT1 XP_454009.1 134691 R 28985 CDS KLLA0_E01365g 2893803 138197..139474 E 1 NC_006041.1 highly similar to uniprot|Q12377 Saccharomyces cerevisiae YDL097C RPN6 Essential non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome the human homolog (S9 protein) partially rescues Rpn6p depletion; proteasome regulatory particle lid subunit RPN6 139474 2893803 KLLA0_E01365g Kluyveromyces lactis proteasome regulatory particle lid subunit RPN6 XP_454010.1 138197 D 28985 CDS KLLA0_E01387g 2893693 complement(139568..140275) E 1 NC_006041.1 similar to uniprot|Q03796 Saccharomyces cerevisiae YMR156C TPP1 DNA 3'-phosphatase that functions in the repair of endogenous DNA damage; functionally redundant with Apn1p and Apn2p; polynucleotide 3'-phosphatase 140275 2893693 KLLA0_E01387g Kluyveromyces lactis polynucleotide 3'-phosphatase XP_454011.1 139568 R 28985 CDS KLLA0_E01409g 2894221 140505..141065 E 1 NC_006041.1 similar to uniprot|Q12368 Saccharomyces cerevisiae YDL098C SNU23 23 kD U4/U6.U5 snRNP associated protein Putative RNA binding zinc finger protein; U4/U6-U5 snRNP complex subunit SNU23 141065 2894221 KLLA0_E01409g Kluyveromyces lactis U4/U6-U5 snRNP complex subunit SNU23 XP_454012.1 140505 D 28985 CDS KLLA0_E01431g 2894223 complement(141256..141909) E 1 NC_006041.1 similar to uniprot|Q03798 Saccharomyces cerevisiae YMR157C FMP39 The authentic non-tagged protein was localized to the mitochondria; uncharacterized protein 141909 2894223 KLLA0_E01431g Kluyveromyces lactis uncharacterized protein XP_454013.1 141256 R 28985 CDS KLLA0_E01453g 2894531 142457..142924 E 1 NC_006041.1 highly similar to uniprot|Q03799 Saccharomyces cerevisiae YMR158W MRPS8 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein uS8m 142924 2894531 KLLA0_E01453g Kluyveromyces lactis mitochondrial 37S ribosomal protein uS8m XP_454014.1 142457 D 28985 CDS KLLA0_E01475g 2894513 complement(143257..144213) E 1 NC_006041.1 weakly similar to uniprot|Q12191 Saccharomyces cerevisiae YDL099W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; uncharacterized protein 144213 2894513 KLLA0_E01475g Kluyveromyces lactis uncharacterized protein XP_454015.1 143257 R 28985 CDS KLLA0_E01497g 2894749 144767..145816 E 1 NC_006041.1 highly similar to uniprot|Q12154 Saccharomyces cerevisiae YDL100C ARR4 ATPase involved in resistance to heat and metal stress active as a dimer normally localized to the cytosol but appears to localize to late endosomes under stress conditions; guanine nucleotide exchange factor GET3 145816 2894749 KLLA0_E01497g Kluyveromyces lactis guanine nucleotide exchange factor GET3 XP_454016.1 144767 D 28985 CDS KLLA0_E01541g 2894240 complement(146269..146649) E 1 NC_006041.1 some similarities with uniprot|Q03818 Saccharomyces cerevisiae YMR159C ATG16 Protein that interacts with the Atg12p-Atg5p conjugate during formation of the pre-autophagosomal structure essential for autophagy; uncharacterized protein 146649 2894240 KLLA0_E01541g Kluyveromyces lactis uncharacterized protein XP_454017.1 146269 R 28985 CDS KLLA0_E01563g 2894231 146955..149105 E 1 NC_006041.1 similar to uniprot|Q03823 Saccharomyces cerevisiae YMR160W Hypothetical ORF; uncharacterized protein 149105 2894231 KLLA0_E01563g Kluyveromyces lactis uncharacterized protein XP_454018.1 146955 D 28985 CDS KLLA0_E01585g 9487424 join(149305..149370,149488..150960) E 1 NC_006041.1 similar to uniprot|P39009 Saccharomyces cerevisiae YDL101C DUN1 Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes phosphorylation of Rad55p and Sml1p and transient G2/M arrest after DNA damage also regulates postreplicative DNA repair; serine/threonine protein kinase DUN1 150960 9487424 KLLA0_E01585g Kluyveromyces lactis serine/threonine protein kinase DUN1 XP_002999388.1 149305 D 28985 CDS KLLA0_E01607g 2894580 complement(151015..154320) E 1 NC_006041.1 highly similar to uniprot|P15436 Saccharomyces cerevisiae YDL102W CDC2 Catalytic subunit of DNA polymerase delta required for chromosomal DNA replication during mitosis and meiosis intragenic recombination repair of double strand DNA breaks and DNA replication during nucleotide excision repair (NER); DNA-directed DNA polymerase delta POL3 154320 2894580 KLLA0_E01607g Kluyveromyces lactis DNA-directed DNA polymerase delta POL3 XP_454020.1 151015 R 28985 CDS KLLA0_E01629g 2894497 155088..155783 E 1 NC_006041.1 similar to uniprot|P48353 Saccharomyces cerevisiae YMR161W; type I HSP40 co-chaperone HLJ1 155783 2894497 KLLA0_E01629g Kluyveromyces lactis type I HSP40 co-chaperone HLJ1 XP_454021.1 155088 D 28985 CDS KLLA0_E01651g 2894443 complement(155975..160627) E 1 NC_006041.1 similar to uniprot|Q12674 Saccharomyces cerevisiae YMR162C DNF3 Non-essential P-type ATPase that is a potential aminophospholipid translocase localizes to the trans-Golgi likely involved in protein transport; aminophospholipid-translocating P4-type ATPase DNF3 160627 2894443 KLLA0_E01651g Kluyveromyces lactis aminophospholipid-translocating P4-type ATPase DNF3 XP_454022.1 155975 R 28985 CDS KLLA0_E01673g 2893723 161221..162633 E 1 NC_006041.1 similar to uniprot|P43123 Saccharomyces cerevisiae YDL103C QRI1 UDP-N-acetylglucosamine pyrophosphorylase catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc) which is important in cell wall biosynthesis protein N-glycosylation and GPI anchor biosynthesis; UDP-N-acetylglucosamine diphosphorylase 162633 2893723 KLLA0_E01673g Kluyveromyces lactis UDP-N-acetylglucosamine diphosphorylase XP_454023.1 161221 D 28985 CDS KLLA0_E01695g 2893907 complement(162748..164748) E 1 NC_006041.1 weakly similar to uniprot|Q03824 Saccharomyces cerevisiae YMR163C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; uncharacterized protein 164748 2893907 KLLA0_E01695g Kluyveromyces lactis uncharacterized protein XP_454024.1 162748 R 28985 CDS KLLA0_E01717g 2893689 complement(165223..166842) E 1 NC_006041.1 some similarities with uniprot|Q03825 Saccharomyces cerevisiae YMR164C MSS11 Transcription factor involved in regulation of invasive growth and starch degradation controls the activation of MUC1 and STA2 in response to nutritional signals; uncharacterized protein 166842 2893689 KLLA0_E01717g Kluyveromyces lactis uncharacterized protein XP_454025.1 165223 R 28985 CDS KLLA0_E01739g 2893886 complement(167644..168996) E 1 NC_006041.1 weakly similar to uniprot|P07390 Saccharomyces cerevisiae YNR045W PET494 Specific translational activator for the COX3 mRNA that acts together with Pet54p and Pet122p located in the mitochondrial inner membrane; uncharacterized protein 168996 2893886 KLLA0_E01739g Kluyveromyces lactis uncharacterized protein XP_454026.1 167644 R 28985 CDS KLLA0_E01761g 2893902 169765..170334 E 1 NC_006041.1 weakly similar to uniprot|P26188 Saccharomyces cerevisiae YDL200c, DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage; methylated-DNA--protein-cysteine methyltransferase 170334 2893902 KLLA0_E01761g Kluyveromyces lactis methylated-DNA--protein-cysteine methyltransferase XP_454027.1 169765 D 28985 CDS KLLA0_E01783g 2894019 171319..173037 E 1 NC_006041.1 similar to uniprot|Q12300 Saccharomyces cerevisiae YDL138w, glucose receptor; uncharacterized protein 173037 2894019 KLLA0_E01783g Kluyveromyces lactis uncharacterized protein XP_454028.1 171319 D 28985 CDS KLLA0_E01805g 2894157 complement(173125..174093) E 1 NC_006041.1 similar to uniprot|P25379 Saccharomyces cerevisiae YCL064C CHA1 catabolism of hydroxy amino acids catabolic serine (threonine) dehydratase; uncharacterized protein 174093 2894157 KLLA0_E01805g Kluyveromyces lactis uncharacterized protein XP_454029.1 173125 R 28985 CDS KLLA0_E01827g 2894256 174481..175047 E 1 NC_006041.1 similar to uniprot|Q12517 Saccharomyces cerevisiae YOL149W DCP1 Decapping enzyme essential phosphoprotein component of mRNA decapping complex plays key role in mRNA decay by cleaving off the 5' cap to leave the end susceptible to exonucleolytic degradation regulated by DEAD box protein Dhh1p; uncharacterized protein 175047 2894256 KLLA0_E01827g Kluyveromyces lactis uncharacterized protein XP_454030.1 174481 D 28985 CDS KLLA0_E01849g 2894229 complement(175162..176991) E 1 NC_006041.1 weakly similar to uniprot|P50875 Saccharomyces cerevisiae YOL148C SPT20 Subunit of the SAGA transcriptional regulatory complex involved in maintaining the integrity of the complex; uncharacterized protein 176991 2894229 KLLA0_E01849g Kluyveromyces lactis uncharacterized protein XP_454031.1 175162 R 28985 CDS KLLA0_E01871g 2894204 complement(177514..178218) E 1 NC_006041.1 similar to uniprot|Q12462 Saccharomyces cerevisiae YOL147C PEX11 Peroxisomal membrane protein required for peroxisome proliferation and medium-chain fatty acid oxidation most abundant protein in the peroxisomal membrane regulated by Adr1p and Pip2p-Oaf1p promoter contains ORE and UAS1-like elements; uncharacterized protein 178218 2894204 KLLA0_E01871g Kluyveromyces lactis uncharacterized protein XP_454032.1 177514 R 28985 CDS KLLA0_E01893g 2894483 179231..179797 E 1 NC_006041.1 similar to uniprot|Q12146 Saccharomyces cerevisiae YOL146W PSF3 Subunit of the GINS complex (Sld5p Psf1p Psf2p Psf3p) which binds to DNA replication origins and facilitates assembly of the DNA replication machinery; DNA replication protein PSF3 179797 2894483 KLLA0_E01893g Kluyveromyces lactis DNA replication protein PSF3 XP_454033.1 179231 D 28985 CDS KLLA0_E01915g 2893707 complement(180022..183243) E 1 NC_006041.1 similar to uniprot|P89105 Saccharomyces cerevisiae YOL145C CTR9 Component of the Paf1p complex which is a large complex that binds to and modulates the activity of RNA polymerase II and is required for expression of a subset of genes including cyclin genes contains TPR repeats; uncharacterized protein 183243 2893707 KLLA0_E01915g Kluyveromyces lactis uncharacterized protein XP_454034.1 180022 R 28985 CDS KLLA0_E01937g 2893644 183638..185092 E 1 NC_006041.1 similar to uniprot|Q08287 Saccharomyces cerevisiae YOL144W NOP8 Nucleolar protein required for 60S ribosomal subunit biogenesis; uncharacterized protein 185092 2893644 KLLA0_E01937g Kluyveromyces lactis uncharacterized protein XP_454035.1 183638 D 28985 CDS KLLA0_E01959g 2894130 complement(185188..185691) E 1 NC_006041.1 highly similar to uniprot|P50861 Saccharomyces cerevisiae YOL143C RIB4 Lumazine synthase (6 7-dimethyl-8-ribityllumazine synthase also known as DMRL synthase) catalyzes synthesis of immediate precursor to riboflavin; lumazine synthase RIB4 185691 2894130 KLLA0_E01959g Kluyveromyces lactis lumazine synthase RIB4 XP_454036.1 185188 R 28985 CDS KLLA0_E01981g 2894684 complement(186177..187475) E 1 NC_006041.1 highly similar to uniprot|P32561 Saccharomyces cerevisiae YNL330C RPD3 Histone deacetylase regulates transcription and silencing; histone deacetylase RPD3 187475 2894684 KLLA0_E01981g Kluyveromyces lactis histone deacetylase RPD3 XP_454037.1 186177 R 28985 CDS KLLA0_E02003g 2893978 complement(187814..190816) E 1 NC_006041.1 similar to uniprot|P33760 Saccharomyces cerevisiae YNL329C PEX6 Required for peroxisome assembly Member of the AAA-protein family that includes NSFp and PEX1p; AAA family ATPase peroxin 6 190816 2893978 KLLA0_E02003g Kluyveromyces lactis AAA family ATPase peroxin 6 XP_454038.1 187814 R 28985 CDS KLLA0_E02025g 2894013 complement(191062..191502) E 1 NC_006041.1 similar to uniprot|P42834 Saccharomyces cerevisiae YNL328C MDJ2 Protein of the mitochondrial inner membrane function partially overlaps that of Mdj1p which is a chaperone involved in folding of mitochondrially synthesized proteins in the mitochondrial matrix member of the DnaJ family; uncharacterized protein 191502 2894013 KLLA0_E02025g Kluyveromyces lactis uncharacterized protein XP_454039.1 191062 R 28985 CDS KLLA0_E02047g 2894131 192747..194939 E 1 NC_006041.1 weakly similar to uniprot|P42835 Saccharomyces cerevisiae YNL327W EGT2 Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner; uncharacterized protein 194939 2894131 KLLA0_E02047g Kluyveromyces lactis uncharacterized protein XP_454040.1 192747 D 28985 CDS KLLA0_E02069g 2894120 complement(195185..196162) E 1 NC_006041.1 weakly similar to uniprot|P42836 Saccharomyces cerevisiae YNL326C PFA3 Palmitoyltransferase for Vac8p one of three yeast DHHC-cysteine rich domain proteins (Pfa3p Erf2p Akr1p) with palmitoyltransferase activity required for vacuolar integrity under stress conditions; palmitoyltransferase PFA3 196162 2894120 KLLA0_E02069g Kluyveromyces lactis palmitoyltransferase PFA3 XP_454041.1 195185 R 28985 CDS KLLA0_E02091g 2894663 196450..197172 E 1 NC_006041.1 similar to uniprot|Q08285 Saccharomyces cerevisiae YOL142W RRP40 Ribosomal RNA Processing Rrp40p; exosome non-catalytic core subunit RRP40 197172 2894663 KLLA0_E02091g Kluyveromyces lactis exosome non-catalytic core subunit RRP40 XP_454042.1 196450 D 28985 CDS KLLA0_E02113g 2894446 complement(197197..199797) E 1 NC_006041.1 similar to uniprot|P42837 Saccharomyces cerevisiae YNL325C FIG4 Protein required for efficient mating member of a family of eukaryotic proteins that contain a domain homologous to Sac1p; phosphatidylinositol-3,5-bisphosphate 5-phosphatase 199797 2894446 KLLA0_E02113g Kluyveromyces lactis phosphatidylinositol-3,5-bisphosphate 5-phosphatase XP_454043.1 197197 R 28985 CDS KLLA0_E02135g 2893682 complement(200436..202055) E 1 NC_006041.1 similar to uniprot|P46950 Saccharomyces cerevisiae YGR197C SNG1 Protein involved in nitrosoguanidine resistance and weakly similar to YJR015W uniprot|P47090 Saccharomyces cerevisiae YJR015W Hypothetical ORF; uncharacterized protein 202055 2893682 KLLA0_E02135g Kluyveromyces lactis uncharacterized protein XP_454044.1 200436 R 28985 CDS KLLA0_E02157g 2893709 complement(202891..203262) E 1 NC_006041.1 no similarity; uncharacterized protein 203262 2893709 KLLA0_E02157g Kluyveromyces lactis uncharacterized protein XP_454045.1 202891 R 28985 CDS KLLA0_E02179g 2894053 203854..205143 E 1 NC_006041.1 similar to uniprot|P42838 YNL323W Saccharomyces cerevisiae YNL323W LEM3 Membrane protein of the plasma membrane and ER; uncharacterized protein 205143 2894053 KLLA0_E02179g Kluyveromyces lactis uncharacterized protein XP_454046.1 203854 D 28985 CDS KLLA0_E02201g 2893993 complement(205466..207973) E 1 NC_006041.1 weakly similar to uniprot|P33301 Saccharomyces cerevisiae YDR369C XRS2 classified as an early recombination function required for DNA repair but dispensable for mitotic recombination (xrs2 is hyper-Rec during vegatative growth) required for double strand breaks meiotic recombination and spore viability DNA repair protein; uncharacterized protein 207973 2893993 KLLA0_E02201g Kluyveromyces lactis uncharacterized protein XP_454047.1 205466 R 28985 CDS KLLA0_E02223g 2893988 complement(208267..209709) E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 209709 2893988 KLLA0_E02223g Kluyveromyces lactis uncharacterized protein XP_454048.1 208267 R 28985 CDS KLLA0_E02245g 2894233 complement(210001..211212) E 1 NC_006041.1 weakly similar to uniprot|Q06349 Saccharomyces cerevisiae YDR370C Hypothetical ORF; uncharacterized protein 211212 2894233 KLLA0_E02245g Kluyveromyces lactis uncharacterized protein XP_454049.1 210001 R 28985 CDS KLLA0_E02267g 2894212 212406..212717 E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 212717 2894212 KLLA0_E02267g Kluyveromyces lactis uncharacterized protein XP_454050.1 212406 D 28985 CDS KLLA0_E02289g 2894534 complement(join(212983..213350,213571..213583)) E 1 NC_006041.1 highly similar to uniprot|P07274 Saccharomyces cerevisiae YOR122C PFY1 Profilin actin- and phosphatidylinositol 4 5-bisphosphate-binding protein plays a role in cytoskeleton organization required for normal timing of actin polymerization in response to thermal stress localizes to plasma membrane and cytosol; profilin 213583 2894534 KLLA0_E02289g Kluyveromyces lactis profilin XP_454051.1 212983 R 28985 CDS KLLA0_E02311g 2894218 complement(214032..215285) E 1 NC_006041.1 similar to uniprot|P38439 Saccharomyces cerevisiae YOR123C LEO1 Component of the Paf1 complex which associates with RNA polymerase II and is involved in histone methylation; uncharacterized protein 215285 2894218 KLLA0_E02311g Kluyveromyces lactis uncharacterized protein XP_454052.1 214032 R 28985 CDS KLLA0_E02333g 2893883 215594..217036 E 1 NC_006041.1 similar to uniprot|Q06350 Saccharomyces cerevisiae YDR371W CTS2 Sporulation-specific chitinase; uncharacterized protein 217036 2893883 KLLA0_E02333g Kluyveromyces lactis uncharacterized protein XP_454053.1 215594 D 28985 CDS KLLA0_E02355g 2893901 complement(217222..218196) E 1 NC_006041.1 highly similar to uniprot|Q06385 Saccharomyces cerevisiae YDR372C VPS74; uncharacterized protein 218196 2893901 KLLA0_E02355g Kluyveromyces lactis uncharacterized protein XP_454054.1 217222 R 28985 CDS KLLA0_E02377g 2894270 complement(218647..222309) E 1 NC_006041.1 uniprot|O42726 Kluyveromyces lactis UBP2 Ubiquitin carboxyl-terminal hydrolase 2; ubiquitin-specific protease UBP2 222309 2894270 KLLA0_E02377g Kluyveromyces lactis ubiquitin-specific protease UBP2 XP_454055.1 218647 R 28985 CDS KLLA0_E02399g 2893663 223247..223819 E 1 NC_006041.1 highly similar to uniprot|Q06389 Saccharomyces cerevisiae YDR373W FRQ1 N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p member of the recoverin/frequenin branch of the EF-hand superfamily; frequenin 223819 2893663 KLLA0_E02399g Kluyveromyces lactis frequenin XP_454056.1 223247 D 28985 CDS KLLA0_E02421g 2893919 complement(224180..224890) E 1 NC_006041.1 highly similar to uniprot|P41735 Saccharomyces cerevisiae YOR125C CAT5 Mitochondrial inner membrane protein directly involved in ubiquinone biosynthesis essential for several other metabolic pathways including respiration and gluconeogenic gene activation; uncharacterized protein 224890 2893919 KLLA0_E02421g Kluyveromyces lactis uncharacterized protein XP_454057.1 224180 R 28985 CDS KLLA0_E02443g 2894262 complement(225413..226207) E 1 NC_006041.1 some similarities with uniprot|Q06390 Saccharomyces cerevisiae YDR374C Hypothetical ORF; mRNA-binding phosphate metabolism regulator 226207 2894262 KLLA0_E02443g Kluyveromyces lactis mRNA-binding phosphate metabolism regulator XP_454058.1 225413 R 28985 CDS KLLA0_E02465g 9487433 226664..226921 E 1 NC_006041.1 similar to uniprot|Q2V2P8 Saccharomyces cerevisiae YDR374W-A; uncharacterized protein 226921 9487433 KLLA0_E02465g Kluyveromyces lactis uncharacterized protein XP_002999389.1 226664 D 28985 CDS KLLA0_E02487g 2894265 complement(227048..228388) E 1 NC_006041.1 highly similar to uniprot|P32839 Saccharomyces cerevisiae YDR375C BCS1 Protein of the mitochondrial inner membrane that functions as an ATP-dependent chaperone required for the assembly of the cytochrome bc(1) complex from the Rip1p and Qcr10p proteins member of the CDC48/PAS1/SEC18 ATPase family; bifunctional AAA family ATPase chaperone/translocase BCS1 228388 2894265 KLLA0_E02487g Kluyveromyces lactis bifunctional AAA family ATPase chaperone/translocase BCS1 XP_454059.1 227048 R 28985 CDS KLLA0_E02509g 2894266 complement(228652..229377) E 1 NC_006041.1 similar to uniprot|P41734 Saccharomyces cerevisiae YOR126C IAH1 Isoamyl acetate-hydrolyzing esterase required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate which is particularly important in sake brewing; isoamyl acetate-hydrolyzing esterase 229377 2894266 KLLA0_E02509g Kluyveromyces lactis isoamyl acetate-hydrolyzing esterase XP_454060.1 228652 R 28985 CDS KLLA0_E02531g 2894268 229894..231330 E 1 NC_006041.1 similar to uniprot|P48360 Saccharomyces cerevisiae YDR376W ARH1 Oxidoreductase of the mitochondrial inner membrane involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes one of the few mitochondrial proteins essential for viability; NADPH-adrenodoxin reductase 231330 2894268 KLLA0_E02531g Kluyveromyces lactis NADPH-adrenodoxin reductase XP_454061.1 229894 D 28985 CDS KLLA0_E02553g 9487531 join(231758..231814,232222..232467) E 1 NC_006041.1 highly similar to uniprot|Q06405 Saccharomyces cerevisae YDR377w, ATP synthase subunit f, ATP17; F1F0 ATP synthase subunit f 232467 9487531 KLLA0_E02553g Kluyveromyces lactis F1F0 ATP synthase subunit f XP_002999390.1 231758 D 28985 CDS KLLA0_E02575g 2894269 complement(233160..233402) E 1 NC_006041.1 similar to uniprot|Q06406 Saccharomyces cerevisiae YDR378C LSM6 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay; U4/U6-U5 snRNP complex subunit LSM6 233402 2894269 KLLA0_E02575g Kluyveromyces lactis U4/U6-U5 snRNP complex subunit LSM6 XP_454062.1 233160 R 28985 CDS KLLA0_E02597g 2894297 234517..237654 E 1 NC_006041.1 weakly similar to uniprot|P39083 Saccharomyces cerevisiae YOR127W RGA1 GTPase-activating protein for the polarity-establishment protein Cdc42p implicated in control of septin organization pheromone response and haploid invasive growth; GTPase-activating protein RGA2 237654 2894297 KLLA0_E02597g Kluyveromyces lactis GTPase-activating protein RGA2 XP_454063.1 234517 D 28985 CDS KLLA0_E02619g 2894401 complement(237959..238198) E 1 NC_006041.1 similar to uniprot|Q3E785 Saccharomyces cerevisiae YDR379C-A Hypothetical ORF; uncharacterized protein 238198 2894401 KLLA0_E02619g Kluyveromyces lactis uncharacterized protein XP_454064.1 237959 R 28985 CDS KLLA0_E02641g 2893774 239180..240838 E 1 NC_006041.1 uniprot|Q8TGC8 Kluyveromyces lactis Putative ceramide glucosyltransferase; uncharacterized protein 240838 2893774 KLLA0_E02641g Kluyveromyces lactis uncharacterized protein XP_454065.1 239180 D 28985 CDS KLLA0_E02663g 2894756 244696..248025 E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 248025 2894756 KLLA0_E02663g Kluyveromyces lactis uncharacterized protein XP_454066.1 244696 D 28985 CDS KLLA0_E02685g 2894665 complement(248162..249871) E 1 NC_006041.1 similar to uniprot|P21264 Saccharomyces cerevisiae YOR128C ADE2 Phosphoribosylaminoimidazole carboxylase catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway red pigment accumulates in mutant cells deprived of adenine; phosphoribosylaminoimidazole carboxylase ADE2 249871 2894665 KLLA0_E02685g Kluyveromyces lactis phosphoribosylaminoimidazole carboxylase ADE2 XP_454067.1 248162 R 28985 CDS KLLA0_E02707g 2893706 251220..253115 E 1 NC_006041.1 similar to uniprot|Q06408 Saccharomyces cerevisiae YDR380W ARO10 Phenylpyruvate decarboxylase catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde which is the first specific step in the Ehrlich pathway; phenylpyruvate decarboxylase ARO10 253115 2893706 KLLA0_E02707g Kluyveromyces lactis phenylpyruvate decarboxylase ARO10 XP_454068.1 251220 D 28985 CDS KLLA0_E02729g 2894041 complement(253382..256117) E 1 NC_006041.1 weakly similar to uniprot|Q92274 Saccharomyces cerevisiae YOR129C Putative component of the outer plaque of the spindle pole body may be involved in cation homeostasis or multidrug resistance; uncharacterized protein 256117 2894041 KLLA0_E02729g Kluyveromyces lactis uncharacterized protein XP_454069.1 253382 R 28985 CDS KLLA0_E02751g 2894049 join(256959..257213,258450..258863) E 1 NC_006041.1 similar to uniprot|Q12159 Saccharomyces cerevisiae YDR381W YRA1 Nuclear protein that binds to RNA and to Mex67p required for export of poly(A) mRNA from the nucleus member of the REF (RNA and export factor binding proteins) family another family member Yra2p can substitute for Yra1p function; RNA-binding protein YRA1 258863 2894049 KLLA0_E02751g Kluyveromyces lactis RNA-binding protein YRA1 XP_454070.1 256959 D 28985 CDS KLLA0_E02773g 2894603 complement(259296..259619) E 1 NC_006041.1 similar to uniprot|Q3E6R5 Saccharomyces cerevisiae YDR381C-A Hypothetical ORF identified by homology; uncharacterized protein 259619 2894603 KLLA0_E02773g Kluyveromyces lactis uncharacterized protein XP_454071.1 259296 R 28985 CDS KLLA0_E02795g 9487493 260349..260516 E 1 NC_006041.1 no similarity; uncharacterized protein 260516 9487493 KLLA0_E02795g Kluyveromyces lactis uncharacterized protein XP_002999391.1 260349 D 28985 CDS KLLA0_E02817g 2893942 260854..261768 E 1 NC_006041.1 weakly similar to uniprot|P39953 Saccharomyces cerevisiae YEL006W Hypothetical ORF9; uncharacterized protein 261768 2893942 KLLA0_E02817g Kluyveromyces lactis uncharacterized protein XP_454072.1 260854 D 28985 CDS KLLA0_E02839g 2893943 complement(261895..262749) E 1 NC_006041.1 similar to uniprot|Q12375 Saccharomyces cerevisiae YOR130C ORT1 Ornithine transporter of the mitochondrial inner membrane exports ornithine from mitochondria as part of arginine biosynthesis human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome; uncharacterized protein 262749 2893943 KLLA0_E02839g Kluyveromyces lactis uncharacterized protein XP_454073.1 261895 R 28985 CDS KLLA0_E02861g 2894018 263645..263974 E 1 NC_006041.1 similar to uniprot|P02400 Saccharomyces cerevisiae YDR382W RPP2B Ribosomal protein P2 beta a component of the ribosomal stalk which is involved in the interaction between translational elongation factors and the ribosome regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm; ribosomal protein P2 263974 2894018 KLLA0_E02861g Kluyveromyces lactis ribosomal protein P2 XP_454074.1 263645 D 28985 CDS KLLA0_E02883g 2894038 complement(264203..264835) E 1 NC_006041.1 similar to uniprot|Q12493 Saccharomyces cerevisiae YDR383C; uncharacterized protein 264835 2894038 KLLA0_E02883g Kluyveromyces lactis uncharacterized protein XP_454075.1 264203 R 28985 CDS KLLA0_E02905g 2893780 complement(265432..266232) E 1 NC_006041.1 similar to uniprot|Q12359 Saccharomyces cerevisiae YDR384C ATO3 Plasma membrane protein regulation pattern suggests a possible role in export of ammonia from the cell member of the TC 9.B.33 YaaH family of putative transporters; uncharacterized protein 266232 2893780 KLLA0_E02905g Kluyveromyces lactis uncharacterized protein XP_454076.1 265432 R 28985 CDS KLLA0_E02927g 2894235 complement(267778..268788) E 1 NC_006041.1 some similarities with uniprot|Q12359 Saccharomyces cerevisiae YDR384C ATO3 Plasma membrane protein regulation pattern suggests a possible role in export of ammonia from the cell member of the TC 9.B.33 YaaH family of putative transporters; uncharacterized protein 268788 2894235 KLLA0_E02927g Kluyveromyces lactis uncharacterized protein XP_454077.1 267778 R 28985 CDS KLLA0_E02949g 9487322 complement(join(270871..271412,271513..271603)) E 1 NC_006041.1 similar to uniprot|Q12486 Saccharomyces cerevisiae YOR131C Hypothetical ORF; uncharacterized protein 271603 9487322 KLLA0_E02949g Kluyveromyces lactis uncharacterized protein XP_002999392.1 270871 R 28985 CDS KLLA0_E02971g 2893786 271880..273535 E 1 NC_006041.1 similar to uniprot|P32913 Saccharomyces cerevisiae YOR132W VPS17 Peripheral membrane protein required for vacuolar protein sorting; retromer subunit VPS17 273535 2893786 KLLA0_E02971g Kluyveromyces lactis retromer subunit VPS17 XP_454079.1 271880 D 28985 CDS KLLA0_E02993g 2893753 274095..276623 E 1 NC_006041.1 highly similar to uniprot|P32324 Saccharomyces cerevisiae YOR133W EFT1 and to uniprot|P32324 Saccharomyces cerevisiae YDR385W EFT2 Elongation factors; elongation factor 2 276623 2893753 KLLA0_E02993g Kluyveromyces lactis elongation factor 2 XP_454080.1 274095 D 28985 CDS KLLA0_E03015g 2893880 277093..278937 E 1 NC_006041.1 similar to uniprot|Q04149 Saccharomyces cerevisiae YDR386W MUS81 Helix-hairpin-helix protein involved in DNA repair and replication fork stability functions as an endonuclease in complex with Mms4p interacts with Rad54p; uncharacterized protein 278937 2893880 KLLA0_E03015g Kluyveromyces lactis uncharacterized protein XP_454081.1 277093 D 28985 CDS KLLA0_E03037g 2894003 complement(278965..280587) E 1 NC_006041.1 similar to uniprot|Q04162 Saccharomyces cerevisiae YDR387C Hypothetical ORF; uncharacterized protein 280587 2894003 KLLA0_E03037g Kluyveromyces lactis uncharacterized protein XP_454082.1 278965 R 28985 CDS KLLA0_E03059g 2893690 281543..282829 E 1 NC_006041.1 similar to uniprot|P39743 Saccharomyces cerevisiae YDR388W RVS167 BAR adaptor protein subunit of a complex (Rvs161p-Rvs167p) that regulates actin endocytosis and viability following starvation or osmotic stress; amphiphysin 282829 2893690 KLLA0_E03059g Kluyveromyces lactis amphiphysin XP_454083.1 281543 D 28985 CDS KLLA0_E03081g 2893691 284154..285815 E 1 NC_006041.1 similar to uniprot|P17121 Saccharomyces cerevisiae YDR389W SAC7 and similar to uniprot|Q12128 Saccharomyces cerevisiae YOR134W BAG7 GTPase activating proteins; uncharacterized protein 285815 2893691 KLLA0_E03081g Kluyveromyces lactis uncharacterized protein XP_454084.1 284154 D 28985 CDS KLLA0_E03103g 2894209 complement(286113..287987) E 1 NC_006041.1 similar to uniprot|P52488 Saccharomyces cerevisiae YDR390C UBA2 Nuclear protein that acts as a heterodimer with Aos1p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation) which may play a role in protein targeting essential for viability; E1 ubiquitin-activating protein UBA2 287987 2894209 KLLA0_E03103g Kluyveromyces lactis E1 ubiquitin-activating protein UBA2 XP_454085.1 286113 R 28985 CDS KLLA0_E03125g 2894289 288825..289931 E 1 NC_006041.1 highly similar to uniprot|P28241 Saccharomyces cerevisiae YOR136W IDH2 Subunit of mitochondrial NAD()-dependent isocitrate dehydrogenase which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; isocitrate dehydrogenase (NAD(+)) IDH2 289931 2894289 KLLA0_E03125g Kluyveromyces lactis isocitrate dehydrogenase (NAD(+)) IDH2 XP_454086.1 288825 D 28985 CDS KLLA0_E03147g 2893910 complement(290622..292358) E 1 NC_006041.1 weakly similar to uniprot|Q12212 Saccharomyces cerevisiae YOR137C SIA1 Suppressor of eIF5A High-copy suppressor of temperature-sensitive tif51A-1; uncharacterized protein 292358 2893910 KLLA0_E03147g Kluyveromyces lactis uncharacterized protein XP_454087.1 290622 R 28985 CDS KLLA0_E03169g 2894535 complement(292918..294552) E 1 NC_006041.1 weakly similar to uniprot|Q12242 Saccharomyces cerevisiae YOR138C RUP1; uncharacterized protein 294552 2894535 KLLA0_E03169g Kluyveromyces lactis uncharacterized protein XP_454088.1 292918 R 28985 CDS KLLA0_E03191g 2894741 296592..298904 E 1 NC_006041.1 some similarities with uniprot|P20134 Saccharomyces cerevisiae YOR140W SFL1 Transcription factor with domains homologous to Hsf1p and to myc oncoprotein required for normal cell surface assembly and flocculence; uncharacterized protein 298904 2894741 KLLA0_E03191g Kluyveromyces lactis uncharacterized protein XP_454089.1 296592 D 28985 CDS KLLA0_E03213g 2894174 complement(299014..301380) E 1 NC_006041.1 similar to uniprot|Q12386 Saccharomyces cerevisiae YOR141C ARP8 Nuclear actin-related protein involved in chromatin remodeling component of chromatin-remodeling enzyme complexes; uncharacterized protein 301380 2894174 KLLA0_E03213g Kluyveromyces lactis uncharacterized protein XP_454090.1 299014 R 28985 CDS KLLA0_E03235g 2894006 302753..303709 E 1 NC_006041.1 similar to uniprot|P53598 Saccharomyces cerevisiae YOR142W LSC1 Alpha subunit of succinyl-CoA ligase which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; succinate--CoA ligase (GDP-forming) subunit alpha 303709 2894006 KLLA0_E03235g Kluyveromyces lactis succinate--CoA ligase (GDP-forming) subunit alpha XP_454091.1 302753 D 28985 CDS KLLA0_E03257g 2894658 complement(304025..304939) E 1 NC_006041.1 similar to uniprot|P35202 YOR143C Saccharomyces cerevisiae THI80 Thiamine pyrophosphokinase; thiamine diphosphokinase 304939 2894658 KLLA0_E03257g Kluyveromyces lactis thiamine diphosphokinase XP_454092.1 304025 R 28985 CDS KLLA0_E03279g 2894275 305245..306231 E 1 NC_006041.1 uniprot|O13472 Kluyveromyces lactis KLLA0E03212g SPT3 Protein; transcriptional regulator SPT3 306231 2894275 KLLA0_E03279g Kluyveromyces lactis transcriptional regulator SPT3 XP_454093.1 305245 D 28985 CDS KLLA0_E03301g 2894716 complement(306319..308568) E 1 NC_006041.1 weakly similar to uniprot|Q12050 Saccharomyces cerevisiae YOR144C ELG1 Protein required for S phase progression and telomere homeostasis; uncharacterized protein 308568 2894716 KLLA0_E03301g Kluyveromyces lactis uncharacterized protein XP_454094.1 306319 R 28985 CDS KLLA0_E03323g 2894717 complement(309039..309716) E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 309716 2894717 KLLA0_E03323g Kluyveromyces lactis uncharacterized protein XP_454095.1 309039 R 28985 CDS KLLA0_E03345g 2893834 complement(309713..310453) E 1 NC_006041.1 similar to uniprot|Q03337 Saccharomyces cerevisiae YDR472W TRS31 Component of the targeting complex (TRAPP) involved in ER to Golgi membrane traffic; TRAPP subunit TRS31 310453 2893834 KLLA0_E03345g Kluyveromyces lactis TRAPP subunit TRS31 XP_454096.1 309713 R 28985 CDS KLLA0_E03367g 2893909 310765..311457 E 1 NC_006041.1 highly similar to uniprot|P07347 Saccharomyces cerevisiae YHR013C ARD1 Subunit of the N-terminal acetyltransferase NatA (Nat1p Ard1p Nat5p) N-terminally acetylates many proteins which influences multiple processes such as the cell cycle heat-shock resistance mating sporulation and telomeric silencing; peptide alpha-N-acetyltransferase complex A subunit ARD1 311457 2893909 KLLA0_E03367g Kluyveromyces lactis peptide alpha-N-acetyltransferase complex A subunit ARD1 XP_454097.1 310765 D 28985 CDS KLLA0_E03411g 2894227 complement(join(312058..312849,312943..312990)) E 1 NC_006041.1 similar to uniprot|P38759 Saccharomyces cerevisiae YHR012W VPS29 Protein involved in vacuolar protein sorting; retromer subunit VPS29 312990 2894227 KLLA0_E03411g Kluyveromyces lactis retromer subunit VPS29 XP_454098.1 312058 R 28985 CDS KLLA0_E03433g 2894059 complement(313281..314615) E 1 NC_006041.1 similar to uniprot|P38705 Saccharomyces cerevisiae YHR011W DIA4 Probable mitochondrial seryl-tRNA synthetase; uncharacterized protein 314615 2894059 KLLA0_E03433g Kluyveromyces lactis uncharacterized protein XP_454099.1 313281 R 28985 CDS KLLA0_E03455g 2893895 complement(join(314899..315278,315870..315900)) E 1 NC_006041.1 highly similar to uniprot|P38706 Saccharomyces cerevisiae YHR010W RPL27A and to uniprot|P38706 Saccharomyces cerevisiae YDR471W RPL27B proteins component of the large (60S) ribosomal subunit; 60S ribosomal protein eL27 315900 2893895 KLLA0_E03455g Kluyveromyces lactis 60S ribosomal protein eL27 XP_454100.1 314899 R 28985 CDS KLLA0_E03477g 2894140 316716..317579 E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 317579 2894140 KLLA0_E03477g Kluyveromyces lactis uncharacterized protein XP_454101.1 316716 D 28985 CDS KLLA0_E03499g 2894141 317949..319391 E 1 NC_006041.1 similar to uniprot|Q03327 Saccharomyces cerevisiae YDR470C UGO1; uncharacterized protein 319391 2894141 KLLA0_E03499g Kluyveromyces lactis uncharacterized protein XP_454102.1 317949 D 28985 CDS KLLA0_E03521g 2894657 complement(319500..319904) E 1 NC_006041.1 some similarities with uniprot|Q03323 Saccharomyces cerevisiae YDR469W SDC1 Subunit of the COMPASS complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; uncharacterized protein 319904 2894657 KLLA0_E03521g Kluyveromyces lactis uncharacterized protein XP_454103.1 319500 R 28985 CDS KLLA0_E03543g 2893702 320167..320862 E 1 NC_006041.1 similar to uniprot|Q03322 Saccharomyces cerevisiae YDR468C TLG1 member of the syntaxin family of t-SNAREs tSNARE that affects a Late Golgi compartment; uncharacterized protein 320862 2893702 KLLA0_E03543g Kluyveromyces lactis uncharacterized protein XP_454104.1 320167 D 28985 CDS KLLA0_E03565g 2894056 321977..323488 E 1 NC_006041.1 similar to uniprot|P38758 Saccharomyces cerevisiae YHR009C Hypothetical ORF; uncharacterized protein 323488 2894056 KLLA0_E03565g Kluyveromyces lactis uncharacterized protein XP_454105.1 321977 D 28985 CDS KLLA0_E03587g 2894190 complement(323764..325707) E 1 NC_006041.1 weakly similar to uniprot|Q03306 YDR466W Saccharomyces cerevisiae YDR466W Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant; protein kinase PKH3 325707 2894190 KLLA0_E03587g Kluyveromyces lactis protein kinase PKH3 XP_454106.1 323764 R 28985 CDS KLLA0_E03609g 2894718 326893..327573 E 1 NC_006041.1 highly similar to uniprot|P00447 Saccharomyces cerevisiae YHR008C SOD2 Manganese-containing superoxide dismutase; superoxide dismutase SOD2 327573 2894718 KLLA0_E03609g Kluyveromyces lactis superoxide dismutase SOD2 XP_454107.1 326893 D 28985 CDS KLLA0_E03631g 2894719 327965..329188 E 1 NC_006041.1 similar to uniprot|Q03305 Saccharomyces cerevisiae YDR465C RMT2 Arginine methyltransferase ribosomal protein L12 is a substrate; protein-arginine N5-methyltransferase 329188 2894719 KLLA0_E03631g Kluyveromyces lactis protein-arginine N5-methyltransferase XP_454108.1 327965 D 28985 CDS KLLA0_E03653g 2893694 329904..331487 E 1 NC_006041.1 highly similar to uniprot|P10614 Saccharomyces cerevisiae YHR007C ERG11 Lanosterol 14-alpha-demethylase catalyzes the C-14 demethylation of lanosterol to form 4 4''-dimethyl cholesta-8 14 24-triene-3-beta-ol in the ergosterol biosynthesis pathway member of the cytochrome P450 family; sterol 14-demethylase 331487 2893694 KLLA0_E03653g Kluyveromyces lactis sterol 14-demethylase XP_454109.1 329904 D 28985 CDS KLLA0_E03675g 2893785 complement(331890..335921) E 1 NC_006041.1 some similarities with uniprot|P38904 Saccharomyces cerevisiae YDR464W SPP41 appears to control expression of spliceosome components PRP4 and PRP3 negative regulator of prp genes; uncharacterized protein 335921 2893785 KLLA0_E03675g Kluyveromyces lactis uncharacterized protein XP_454110.1 331890 R 28985 CDS KLLA0_E03697g 2894245 complement(336505..338727) E 1 NC_006041.1 similar to uniprot|P32486 Saccharomyces cerevisiae YPR159W KRE6 Protein required for beta-1 6 glucan biosynthesis putative beta-glucan synthase appears functionally redundant with Skn1p; uncharacterized protein 338727 2894245 KLLA0_E03697g Kluyveromyces lactis uncharacterized protein XP_454111.1 336505 R 28985 CDS KLLA0_E03719g 2893917 complement(340439..341320) E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 341320 2893917 KLLA0_E03719g Kluyveromyces lactis uncharacterized protein XP_454112.1 340439 R 28985 CDS KLLA0_E03763g 2893617 complement(342937..343965) E 1 NC_006041.1 some similarities with uniprot|P53286 Saccharomyces cerevisiae YGR142W BTN2 Cytosolic coiled-coil protein that modulates arginine uptake interacts with Rhb1p possible role in mediating pH homeostasis between the vacuole and plasma membrane H()-ATPase may have a role in intracellular protein trafficking; uncharacterized protein 343965 2893617 KLLA0_E03763g Kluyveromyces lactis uncharacterized protein XP_454113.1 342937 R 28985 CDS KLLA0_E03785g 2893619 complement(344351..345637) E 1 NC_006041.1 similar to uniprot|P53285 Saccharomyces cerevisiae YGR141W VPS62 and similar to uniprot|Q06466 Saccharomyces cerevisiae YPR157W; uncharacterized protein 345637 2893619 KLLA0_E03785g Kluyveromyces lactis uncharacterized protein XP_454114.1 344351 R 28985 CDS KLLA0_E03807g 2893666 complement(345816..348026) E 1 NC_006041.1 similar to uniprot|Q753I9 Ashbya gossypii AFR323W AFR323Wp and weakly similar to YGR140W uniprot|P32504 Saccharomyces cerevisiae YGR140W CBF2 Essential kinetochore protein component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere Cbf2p also binds to the CDEII region possibly forming a different multimeric complex ubiquitinated in vivo; uncharacterized protein 348026 2893666 KLLA0_E03807g Kluyveromyces lactis uncharacterized protein XP_454115.1 345816 R 28985 CDS KLLA0_E03829g 2893668 349784..351613 E 1 NC_006041.1 highly similar to uniprot|Q06451 Saccharomyces cerevisiae YPR156C TPO3 Polyamine transport protein; uncharacterized protein 351613 2893668 KLLA0_E03829g Kluyveromyces lactis uncharacterized protein XP_454116.1 349784 D 28985 CDS KLLA0_E03851g 2893872 352621..354423 E 1 NC_006041.1 some similarities with uniprot|Q12374 Saccharomyces cerevisiae YPR155C NCA2 Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase functions with Nca3p; uncharacterized protein 354423 2893872 KLLA0_E03851g Kluyveromyces lactis uncharacterized protein XP_454117.1 352621 D 28985 CDS KLLA0_E03873g 2893877 complement(354700..355362) E 1 NC_006041.1 similar to uniprot|Q06449 Saccharomyces cerevisiae YPR154W PIN3 Protein that induces appearance of [PIN ] prion when overproduced; uncharacterized protein 355362 2893877 KLLA0_E03873g Kluyveromyces lactis uncharacterized protein XP_454118.1 354700 R 28985 CDS KLLA0_E03895g 9487517 complement(join(355734..356151,356230..356234)) E 1 NC_006041.1 similar to uniprot|Q06HN0 Saccharomyces cerevisiae YPR153W Hypothetical ORF; uncharacterized protein 356234 9487517 KLLA0_E03895g Kluyveromyces lactis uncharacterized protein XP_002999393.1 355734 R 28985 CDS KLLA0_E03917g 2893875 complement(356540..357289) E 1 NC_006041.1 highly similar to uniprot|P23638 Saccharomyces cerevisiae YGR135W PRE9 20S proteasome beta-type subunit the only nonessential 20S subunit; proteasome core particle subunit alpha 3 357289 2893875 KLLA0_E03917g Kluyveromyces lactis proteasome core particle subunit alpha 3 XP_454120.1 356540 R 28985 CDS KLLA0_E03939g 2893670 357695..359002 E 1 NC_006041.1 similar to uniprot|Q06525 Saccharomyces cerevisiae YPR152C Hypothetical ORF; uncharacterized protein 359002 2893670 KLLA0_E03939g Kluyveromyces lactis uncharacterized protein XP_454121.1 357695 D 28985 CDS KLLA0_E03961g 2893673 complement(358995..362393) E 1 NC_006041.1 weakly similar to uniprot|P53280 Saccharomyces cerevisiae YGR134W CAF130 Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation elongation and degradation; CCR4-NOT core subunit CAF130 362393 2893673 KLLA0_E03961g Kluyveromyces lactis CCR4-NOT core subunit CAF130 XP_454122.1 358995 R 28985 CDS KLLA0_E03983g 2893675 363400..363975 E 1 NC_006041.1 similar to gnl|GLV|CAGL0L08426g Candida glabrata CAGL0L08426g and weakly similar to YPR151C uniprot|Q06524 Saccharomyces cerevisiae YPR151C SUE1 Mitochondrial protein required for degradation of unstable forms of cytochrome c; uncharacterized protein 363975 2893675 KLLA0_E03983g Kluyveromyces lactis uncharacterized protein XP_454123.1 363400 D 28985 CDS KLLA0_E04005g 2893677 complement(364475..364888) E 1 NC_006041.1 weakly similar to uniprot|P40185 Saccharomyces cerevisiae YIL051C MMF1 Mitochondrial protein involved in maintenance of the mitochondrial genome and weakly similar to YER057C uniprot|P40037 Saccharomyces cerevisiae YER057C HMF1 Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro; uncharacterized protein 364888 2893677 KLLA0_E04005g Kluyveromyces lactis uncharacterized protein XP_454124.1 364475 R 28985 CDS KLLA0_E04027g 2893849 complement(365119..365595) E 1 NC_006041.1 similar to uniprot|P29340 Saccharomyces cerevisiae YGR133W PEX4 Involved in peroxisome biogenesis Member of ubiquitin-conjugating protein family; E2 ubiquitin-protein ligase peroxin 4 365595 2893849 KLLA0_E04027g Kluyveromyces lactis E2 ubiquitin-protein ligase peroxin 4 XP_454125.1 365119 R 28985 CDS KLLA0_E04049g 2893850 366535..368304 E 1 NC_006041.1 similar to uniprot|P12630 Saccharomyces cerevisiae YIL015W BAR1 Aspartyl protease secreted into the periplasmic space of mating type a cells, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest and to YLR121C uniprot|Q12303 Saccharomyces cerevisiae YLR121C YPS3 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YLR120C uniprot|P32329 Saccharomyces cerevisiae YLR120C YPS1 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YDR144C uniprot|P53379 Saccharomyces cerevisiae YDR144C MKC7 GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p and to YIR039C uniprot|P40583 Saccharomyces cerevisiae YIR039C YPS6 Putative GPI-anchored aspartic protease, member on vGLC.1466.; uncharacterized protein 368304 2893850 KLLA0_E04049g Kluyveromyces lactis uncharacterized protein XP_454126.1 366535 D 28985 CDS KLLA0_E04071g 2893846 369201..371315 E 1 NC_006041.1 some similarities with uniprot|P22470 Saccharomyces cerevisiae YDR143C SAN1 Ubiquitin-protein ligase controls turnover of a specific class of unstable nuclear proteins including Sir4p but not Sir2p or Sir3p san1 mutations suppress sir4 spt16 and cdc68 mutations suggesting a role in chromatin silencing; ubiquitin-protein ligase SAN1 371315 2893846 KLLA0_E04071g Kluyveromyces lactis ubiquitin-protein ligase SAN1 XP_454127.1 369201 D 28985 CDS KLLA0_E04093g 2893852 371642..372760 E 1 NC_006041.1 similar to uniprot|P39108 Saccharomyces cerevisiae YDR142C PEX7 May serve as intraperoxisomal receptor for type 2 peroxisomal proteins (such as thiolase) Member of beta-transducin-related (WD-40) protein family; uncharacterized protein 372760 2893852 KLLA0_E04093g Kluyveromyces lactis uncharacterized protein XP_454128.1 371642 D 28985 CDS KLLA0_E04115g 2893911 complement(372858..373421) E 1 NC_006041.1 weakly similar to uniprot|Q99176 Saccharomyces cerevisiae YLR119W SRN2 Component of the ESCRT-I complex which is involved in ubiquitin-dependent sorting of proteins into the endosome suppressor of rna1-1 mutation may be involved in RNA export from nucleus; ESCRT-I subunit protein SRN2 373421 2893911 KLLA0_E04115g Kluyveromyces lactis ESCRT-I subunit protein SRN2 XP_454129.1 372858 R 28985 CDS KLLA0_E04137g 2893913 complement(373677..375335) E 1 NC_006041.1 similar to uniprot|P43609 Saccharomyces cerevisiae YFR037C RSC8 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex essential for viability and mitotic growth homolog of SWI/SNF subunit Swi3p but unlike Swi3p does not activate transcription of reporters; uncharacterized protein 375335 2893913 KLLA0_E04137g Kluyveromyces lactis uncharacterized protein XP_454130.1 373677 R 28985 CDS KLLA0_E04159g 2893915 375999..378479 E 1 NC_006041.1 similar to uniprot|P43610 Saccharomyces cerevisiae YFR038W Hypothetical ORF; uncharacterized protein 378479 2893915 KLLA0_E04159g Kluyveromyces lactis uncharacterized protein XP_454131.1 375999 D 28985 CDS KLLA0_E04181g 2893813 378888..380288 E 1 NC_006041.1 similar to uniprot|P07278 YIL033C Saccharomyces cerevisiae BCY1 Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA); cAMP-dependent protein kinase regulatory subunit BCY1 380288 2893813 KLLA0_E04181g Kluyveromyces lactis cAMP-dependent protein kinase regulatory subunit BCY1 XP_454132.1 378888 D 28985 CDS KLLA0_E04203g 2893814 complement(380555..381004) E 1 NC_006041.1 highly similar to uniprot|P40030 Saccharomyces cerevisiae YER044C ERG28 Endoplasmic reticulum membrane protein may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3- ketoreductase and/or tether these enzymes to the ER also interacts with Erg6p; uncharacterized protein 381004 2893814 KLLA0_E04203g Kluyveromyces lactis uncharacterized protein XP_454133.1 380555 R 28985 CDS KLLA0_E04225g 2893811 381615..382454 E 1 NC_006041.1 similar to uniprot|P13517 Saccharomyces cerevisiae YIL034C CAP2 Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization localized predominantly to cortical actin patches; F-actin-capping protein subunit beta 382454 2893811 KLLA0_E04225g Kluyveromyces lactis F-actin-capping protein subunit beta XP_454134.1 381615 D 28985 CDS KLLA0_E04247g 2893816 382874..383995 E 1 NC_006041.1 similar to uniprot|P15790 Saccharomyces cerevisiae YIL035C CKA1 alpha subunit of protein kinase CK2; casein kinase 2 catalytic subunit CKA1 383995 2893816 KLLA0_E04247g Kluyveromyces lactis casein kinase 2 catalytic subunit CKA1 XP_454135.1 382874 D 28985 CDS KLLA0_E04269g 2893823 complement(386095..387441) E 1 NC_006041.1 weakly similar to uniprot|P40535 Saccharomyces cerevisiae YIL036W CST6 Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family activates transcription of genes involved in utilization of non-optimal carbon sources; uncharacterized protein 387441 2893823 KLLA0_E04269g Kluyveromyces lactis uncharacterized protein XP_454137.1 386095 R 28985 CDS KLLA0_E04291g 2893821 388682..389479 E 1 NC_006041.1 some similarities with uniprot|P40031 Saccharomyces cerevisiae YER046W SPO73 Meiosis-specific protein of unknown function required for spore wall formation during sporulation dispensible for both nuclear divisions during meiosis; uncharacterized protein 389479 2893821 KLLA0_E04291g Kluyveromyces lactis uncharacterized protein XP_454138.1 388682 D 28985 CDS KLLA0_E04313g 2893825 389694..391448 E 1 NC_006041.1 weakly similar to uniprot|P40534 Saccharomyces cerevisiae YIL037C Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p, PRM2; uncharacterized protein 391448 2893825 KLLA0_E04313g Kluyveromyces lactis uncharacterized protein XP_454139.1 389694 D 28985 CDS KLLA0_E04335g 2893826 391816..394092 E 1 NC_006041.1 similar to uniprot|Q75AN0 Ashbya gossypii ADL108C ADL108Cp and some similarites with YIL038C uniprot|P06102 Saccharomyces cerevisiae YIL038C NOT3 Subunit of the CCR4-NOT complex which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation; CCR4-NOT core subunit NOT3 394092 2893826 KLLA0_E04335g Kluyveromyces lactis CCR4-NOT core subunit NOT3 XP_454140.1 391816 D 28985 CDS KLLA0_E04357g 2893837 complement(394269..395390) E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 395390 2893837 KLLA0_E04357g Kluyveromyces lactis uncharacterized protein XP_454141.1 394269 R 28985 CDS KLLA0_E04379g 2893635 complement(396027..398216) E 1 NC_006041.1 similar to uniprot|P39955 Saccharomyces cerevisiae YER047C SAP1 Putative ATPase of the AAA family interacts with the Sin1p transcriptional repressor in the two-hybrid system; uncharacterized protein 398216 2893635 KLLA0_E04379g Kluyveromyces lactis uncharacterized protein XP_454142.1 396027 R 28985 CDS KLLA0_E04401g 2893625 complement(398654..400030) E 1 NC_006041.1 similar to uniprot|P40533 Saccharomyces cerevisiae YIL039W Hypothetical ORF; uncharacterized protein 400030 2893625 KLLA0_E04401g Kluyveromyces lactis uncharacterized protein XP_454144.1 398654 R 28985 CDS KLLA0_E04423g 2894063 complement(400495..401781) E 1 NC_006041.1 similar to uniprot|P39101 YER048C Saccharomyces cerevisiae CAJ1 Nuclear type II J heat shock protein of the E. coli dnaJ family; uncharacterized protein 401781 2894063 KLLA0_E04423g Kluyveromyces lactis uncharacterized protein XP_454145.1 400495 R 28985 CDS KLLA0_E04445g 2894066 complement(402193..402642) E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 402642 2894066 KLLA0_E04445g Kluyveromyces lactis uncharacterized protein XP_454146.1 402193 R 28985 CDS KLLA0_E04467g 2894067 403312..403587 E 1 NC_006041.1 similar to uniprot|Q6Q560 Saccharomyces cerevisiae YER048W-A; uncharacterized protein 403587 2894067 KLLA0_E04467g Kluyveromyces lactis uncharacterized protein XP_454147.1 403312 D 28985 CDS KLLA0_E04489g 2894068 404611..406413 E 1 NC_006041.1 similar to uniprot|P40032 Saccharomyces cerevisiae YER049W Hypothetical ORF; oxidative DNA demethylase 406413 2894068 KLLA0_E04489g Kluyveromyces lactis oxidative DNA demethylase XP_454148.1 404611 D 28985 CDS KLLA0_E04511g 2894072 complement(406764..407672) E 1 NC_006041.1 similar to uniprot|P40531 Saccharomyces cerevisiae YIL041W GVP36 Golgi-vesicle protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; uncharacterized protein 407672 2894072 KLLA0_E04511g Kluyveromyces lactis uncharacterized protein XP_454149.1 406764 R 28985 CDS KLLA0_E04533g 2894070 408415..409680 E 1 NC_006041.1 similar to uniprot|P40530 Saccharomyces cerevisiae YIL042C Hypothetical ORF; protein kinase PKP1 409680 2894070 KLLA0_E04533g Kluyveromyces lactis protein kinase PKP1 XP_454150.1 408415 D 28985 CDS KLLA0_E04555g 2894074 complement(409814..410281) E 1 NC_006041.1 some similarities with uniprot|P40033 Saccharomyces cerevisiae YER050C; mitochondrial 37S ribosomal protein bS18m 410281 2894074 KLLA0_E04555g Kluyveromyces lactis mitochondrial 37S ribosomal protein bS18m XP_454151.1 409814 R 28985 CDS KLLA0_E04577g 2894076 complement(410511..410897) E 1 NC_006041.1 no similarity; uncharacterized protein 410897 2894076 KLLA0_E04577g Kluyveromyces lactis uncharacterized protein XP_454152.1 410511 R 28985 CDS KLLA0_E04599g 2894078 complement(411182..411559) E 1 NC_006041.1 no similarity; uncharacterized protein 411559 2894078 KLLA0_E04599g Kluyveromyces lactis uncharacterized protein XP_454153.1 411182 R 28985 CDS KLLA0_E04621g 2894079 412009..413178 E 1 NC_006041.1 some similarites with uniprot|Q06523 Saccharomyces cerevisiae YPR148C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; uncharacterized protein 413178 2894079 KLLA0_E04621g Kluyveromyces lactis uncharacterized protein XP_454154.1 412009 D 28985 CDS KLLA0_E04643g 2894082 complement(413277..413942) E 1 NC_006041.1 similar to uniprot|P53277 Saccharomyces cerevisiae YGR129W SYF2 SYnthetic lethal with cdcForty (putative) involved in pre-mRNA splicing; uncharacterized protein 413942 2894082 KLLA0_E04643g Kluyveromyces lactis uncharacterized protein XP_454155.1 413277 R 28985 CDS KLLA0_E04665g 2894087 414183..416126 E 1 NC_006041.1 similar to uniprot|P53276 Saccharomyces cerevisiae YGR128C UTP8 Nucleolar protein required for export of tRNAs from the nucleus also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; uncharacterized protein 416126 2894087 KLLA0_E04665g Kluyveromyces lactis uncharacterized protein XP_454156.1 414183 D 28985 CDS KLLA0_E04687g 2894088 complement(416178..417098) E 1 NC_006041.1 similar to uniprot|P53275 Saccharomyces cerevisiae YGR127W Hypothetical ORF; uncharacterized protein 417098 2894088 KLLA0_E04687g Kluyveromyces lactis uncharacterized protein XP_454157.1 416178 R 28985 CDS KLLA0_E04709g 2894090 complement(417351..417851) E 1 NC_006041.1 weakly similar to uniprot|P53274 Saccharomyces cerevisiae YGR126W Hypothetical ORF; uncharacterized protein 417851 2894090 KLLA0_E04709g Kluyveromyces lactis uncharacterized protein XP_454158.1 417351 R 28985 CDS KLLA0_E04731g 2894110 complement(418094..421276) E 1 NC_006041.1 similar to uniprot|P53273 Saccharomyces cerevisiae YGR125W Hypothetical ORF; uncharacterized protein 421276 2894110 KLLA0_E04731g Kluyveromyces lactis uncharacterized protein XP_454159.1 418094 R 28985 CDS KLLA0_E04753g 2893903 complement(423256..424248) E 1 NC_006041.1 similar to uniprot|P52919 Saccharomyces cerevisiae YLR457C NBP1 Component of the mitotic apparatus containing a coiled-coil domain essential for the G2/M transition; uncharacterized protein 424248 2893903 KLLA0_E04753g Kluyveromyces lactis uncharacterized protein XP_454160.1 423256 R 28985 CDS KLLA0_E04775g 2893904 424886..427018 E 1 NC_006041.1 similar to uniprot|P24482 Saccharomyces cerevisiae YPR175W DPB2 Second largest subunit of DNA polymerase II (DNA polymerase epsilon) required for normal yeast chromosomal replication expression peaks at the G1/S phase boundary potential Cdc28p substrate; DNA polymerase epsilon noncatalytic subunit 427018 2893904 KLLA0_E04775g Kluyveromyces lactis DNA polymerase epsilon noncatalytic subunit XP_454161.1 424886 D 28985 CDS KLLA0_E04797g 2894571 complement(427096..428070) E 1 NC_006041.1 highly similar to uniprot|P20133 Saccharomyces cerevisiae YPR176C BET2 Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p; Rab geranylgeranyltransferase BET2 428070 2894571 KLLA0_E04797g Kluyveromyces lactis Rab geranylgeranyltransferase BET2 XP_454162.1 427096 R 28985 CDS KLLA0_E04819g 2894503 428278..429657 E 1 NC_006041.1 similar to uniprot|P20053 Saccharomyces cerevisiae YPR178W PRP4 Splicing factor component of the U4/U6-U5 snRNP complex; U4/U6-U5 snRNP complex subunit PRP4 429657 2894503 KLLA0_E04819g Kluyveromyces lactis U4/U6-U5 snRNP complex subunit PRP4 XP_454163.1 428278 D 28985 CDS KLLA0_E04841g 2893633 complement(429714..431624) E 1 NC_006041.1 similar to uniprot|Q06623 Saccharomyces cerevisiae YPR179C, Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; uncharacterized protein 431624 2893633 KLLA0_E04841g Kluyveromyces lactis uncharacterized protein XP_454164.1 429714 R 28985 CDS KLLA0_E04863g 9487340 join(432000..432027,432140..433140) E 1 NC_006041.1 similar to uniprot|Q06624 Saccharomyces cerevisiae YPR180W, RHC31 nuclear protein that acts as a heterodimer with Uba2p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability; E1 ubiquitin-activating protein AOS1 433140 9487340 KLLA0_E04863g Kluyveromyces lactis E1 ubiquitin-activating protein AOS1 XP_002999394.1 432000 D 28985 CDS KLLA0_E04885g 2893755 complement(433298..435580) E 1 NC_006041.1 highly similar to uniprot|P15303 Saccharomyces cerevisiae YPR181C SEC23 cytoplasmic GTPase-activating protein; GTPase-activating protein SEC23 435580 2893755 KLLA0_E04885g Kluyveromyces lactis GTPase-activating protein SEC23 XP_454166.1 433298 R 28985 CDS KLLA0_E04907g 2893783 436221..437399 E 1 NC_006041.1 similar to uniprot|P41733 Saccharomyces cerevisiae YLR459W GAB1 GPI transamidase subunit involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins may have a role in recognition of the attachment signal or of the lipid portion of GPI; GPI-anchor transamidase subunit GAB1 437399 2893783 KLLA0_E04907g Kluyveromyces lactis GPI-anchor transamidase subunit GAB1 XP_454167.1 436221 D 28985 CDS KLLA0_E04929g 2893784 join(437719..437721,437833..438168) E 1 NC_006041.1 similar to uniprot|P54999 Saccharomyces cerevisiae YPR182W SMX3 Sm or Sm-like snRNP protein; mRNA splicing protein SMX3 438168 2893784 KLLA0_E04929g Kluyveromyces lactis mRNA splicing protein SMX3 XP_454168.1 437719 D 28985 CDS KLLA0_E04973g 2894085 complement(439551..440402) E 1 NC_006041.1 similar to uniprot|P18496 Saccharomyces cerevisiae YLR393W ATP10 Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase interacts genetically with ATP6; uncharacterized protein 440402 2894085 KLLA0_E04973g Kluyveromyces lactis uncharacterized protein XP_454169.1 439551 R 28985 CDS KLLA0_E04995g 2893944 complement(440889..441635) E 1 NC_006041.1 some similarities with uniprot|O13547 Saccharomyces cerevisiae YLR390W-A CCW14 Secretory Stress Response protein; uncharacterized protein 441635 2893944 KLLA0_E04995g Kluyveromyces lactis uncharacterized protein XP_454170.1 440889 R 28985 CDS KLLA0_E05017g 2893685 complement(442199..443101) E 1 NC_006041.1 similar to uniprot|Q07418 Saccharomyces cerevisiae YDL065C PEX19 Chaperone and import receptor for newly-synthesized class I peroxisomal membrane proteins; uncharacterized protein 443101 2893685 KLLA0_E05017g Kluyveromyces lactis uncharacterized protein XP_454171.1 442199 R 28985 CDS KLLA0_E05039g 2894145 443446..443919 E 1 NC_006041.1 highly similar to uniprot|P50623 Saccharomyces cerevisiae YDL064W UBC9 SUMO-conjugating enzyme involved in the Smt3p conjugation pathway nuclear protein required for S- and M-phase cyclin degradation and mitotic control involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC); E2 SUMO-conjugating protein UBC9 443919 2894145 KLLA0_E05039g Kluyveromyces lactis E2 SUMO-conjugating protein UBC9 XP_454172.1 443446 D 28985 CDS KLLA0_E05061g 2894031 complement(444262..446112) E 1 NC_006041.1 similar to uniprot|Q7LGT0 Saccharomyces cerevisiae YDL063C; uncharacterized protein 446112 2894031 KLLA0_E05061g Kluyveromyces lactis uncharacterized protein XP_454173.1 444262 R 28985 CDS KLLA0_E05083g 2894032 complement(446469..446741) E 1 NC_006041.1 some similarities with uniprot|Q06011 Saccharomyces cerevisiae YLR390W ECM19 Non-essential protein of unknown function; uncharacterized protein 446741 2894032 KLLA0_E05083g Kluyveromyces lactis uncharacterized protein XP_454174.1 446469 R 28985 CDS KLLA0_E05105g 2893763 447645..450659 E 1 NC_006041.1 similar to uniprot|Q06010 Saccharomyces cerevisiae YLR389C STE23 Metalloprotease involved with homolog Axl1p in N-terminal processing of pro-a-factor to the mature form member of the insulin-degrading enzyme family; metalloendopeptidase 450659 2893763 KLLA0_E05105g Kluyveromyces lactis metalloendopeptidase XP_454175.1 447645 D 28985 CDS KLLA0_E05127g 2894091 complement(451432..451602) E 1 NC_006041.1 highly similar to uniprot|P41058 Saccharomyces cerevisiae YDL061C RPS29B Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Ap and has similarity to rat S29 and E. coli S14 ribosomal proteins; 40S ribosomal protein uS14 451602 2894091 KLLA0_E05127g Kluyveromyces lactis 40S ribosomal protein uS14 XP_454176.1 451432 R 28985 CDS KLLA0_E05149g 2894093 452736..455099 E 1 NC_006041.1 similar to uniprot|Q03128 Saccharomyces cerevisiae YDL060W TSR1 Protein required for processing of 20S pre-rRNA in the cytoplasm associates with pre-40S ribosomal particles; uncharacterized protein 455099 2894093 KLLA0_E05149g Kluyveromyces lactis uncharacterized protein XP_454177.1 452736 D 28985 CDS KLLA0_E05171g 2894103 455399..456664 E 1 NC_006041.1 similar to uniprot|Q06709 Saccharomyces cerevisiae YLR387C CREH1 Protein of unknown function, similar to Rei1p but not involved in bud growth; uncharacterized protein 456664 2894103 KLLA0_E05171g Kluyveromyces lactis uncharacterized protein XP_454178.1 455399 D 28985 CDS KLLA0_E05193g 9487404 complement(join(456708..459331,459433..459436)) E 1 NC_006041.1 similar to uniprot|Q06708 Saccharomyces cerevisiae YLR386W VAC14 Activator of Fab1p; uncharacterized protein 459436 9487404 KLLA0_E05193g Kluyveromyces lactis uncharacterized protein XP_002999395.1 456708 R 28985 CDS KLLA0_E05215g 2894099 459726..460103 E 1 NC_006041.1 weakly similar to uniprot|Q06707 Saccharomyces cerevisiae YLR385C SWC7; uncharacterized protein 460103 2894099 KLLA0_E05215g Kluyveromyces lactis uncharacterized protein XP_454180.1 459726 D 28985 CDS KLLA0_E05237g 2894105 460483..464460 E 1 NC_006041.1 highly similar to uniprot|Q06706 Saccharomyces cerevisiae YLR384C IKI3 Subunit of RNA polymerase II elongator complex which is a histone acetyltransferase involved in maintaining structural integrity of the complex iki3 mutations confer resistance to the K. lactis toxin zymocin; Elongator subunit IKI3 464460 2894105 KLLA0_E05237g Kluyveromyces lactis Elongator subunit IKI3 XP_454181.1 460483 D 28985 CDS KLLA0_E05259g 2894107 complement(464593..465222) E 1 NC_006041.1 similar to uniprot|Q12223 Saccharomyces cerevisiae YDL059C RAD59 Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing anneals complementary single-stranded DNA; uncharacterized protein 465222 2894107 KLLA0_E05259g Kluyveromyces lactis uncharacterized protein XP_454182.1 464593 R 28985 CDS KLLA0_E05281g 2894109 467253..472520 E 1 NC_006041.1 similar to uniprot|P25386 Saccharomyces cerevisiae YDL058W USO1 involved intracellular protein transport coiled-coil protein necessary for protein transport from ER to Golgi Integrin analogue gene; uncharacterized protein 472520 2894109 KLLA0_E05281g Kluyveromyces lactis uncharacterized protein XP_454183.1 467253 D 28985 CDS KLLA0_E05303g 2894033 complement(472583..475879) E 1 NC_006041.1 similar to uniprot|Q12749 Saccharomyces cerevisiae YLR383W RHC18 Protein involved in structural maintenance of chromosomes required for interchromosomal and sister chromatid recombination; DNA repair protein SMC6 475879 2894033 KLLA0_E05303g Kluyveromyces lactis DNA repair protein SMC6 XP_454184.1 472583 R 28985 CDS KLLA0_E05325g 2894486 476546..479173 E 1 NC_006041.1 similar to uniprot|P11325 Saccharomyces cerevisiae YLR382C NAM2 Mitochondrial leucyl-tRNA synthetase also has a direct role in splicing of several mitochondrial group I introns indirectly required for mitochondrial genome maintenance; leucine--tRNA ligase NAM2 479173 2894486 KLLA0_E05325g Kluyveromyces lactis leucine--tRNA ligase NAM2 XP_454185.1 476546 D 28985 CDS KLLA0_E05347g 2894487 complement(479196..481070) E 1 NC_006041.1 similar to uniprot|Q7LHY6 Saccharomyces cerevisiae YLR381W CTF3 Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p may bind the kinetochore to spindle microtubules; uncharacterized protein 481070 2894487 KLLA0_E05347g Kluyveromyces lactis uncharacterized protein XP_454186.1 479196 R 28985 CDS KLLA0_E05369g 2894488 complement(481399..482733) E 1 NC_006041.1 similar to uniprot|Q6B265 Saccharomyces cerevisiae YLR380W CSR1 Phosphatidylinositol transfer protein with a potential role in lipid turnover interacts specifically with thioredoxin peroxidase (Tsa2p) and may have a role in oxidative stress resistance; uncharacterized protein 482733 2894488 KLLA0_E05369g Kluyveromyces lactis uncharacterized protein XP_454187.1 481399 R 28985 CDS KLLA0_E05391g 2894687 483509..485374 E 1 NC_006041.1 similar to uniprot|Q07379 Saccharomyces cerevisiae YDL057W Hypothetical ORF; uncharacterized protein 485374 2894687 KLLA0_E05391g Kluyveromyces lactis uncharacterized protein XP_454188.1 483509 D 28985 CDS KLLA0_E05413g 2894280 485919..488183 E 1 NC_006041.1 uniprot|P39679 Kluyveromyces lactis MBP1 Transcription factor MBP1; transcription factor MBP1 488183 2894280 KLLA0_E05413g Kluyveromyces lactis transcription factor MBP1 XP_454189.1 485919 D 28985 CDS KLLA0_E05435g 2894004 complement(488881..489966) E 1 NC_006041.1 highly similar to uniprot|P41940 Saccharomyces cerevisiae YDL055C PSA1 GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase) synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis required for normal cell wall structure; mannose-1-phosphate guanylyltransferase 489966 2894004 KLLA0_E05435g Kluyveromyces lactis mannose-1-phosphate guanylyltransferase XP_454190.1 488881 R 28985 CDS KLLA0_E05457g 2894729 complement(490709..491107) E 1 NC_006041.1 no similarity; uncharacterized protein 491107 2894729 KLLA0_E05457g Kluyveromyces lactis uncharacterized protein XP_454192.1 490709 R 28985 CDS KLLA0_E05479g 2894730 complement(491391..493229) E 1 NC_006041.1 similar to uniprot|P38196 YBL042C Saccharomyces cerevisiae FUI1 High affinity uridine permease localized to the plasma membrane not involved in uracil transport; uridine permease 493229 2894730 KLLA0_E05479g Kluyveromyces lactis uridine permease XP_454193.1 491391 R 28985 CDS KLLA0_E05501g 9487387 complement(494499..495056) E 1 NC_006041.1 similar to uniprot|P47142 Saccharomyces cerevisiae YJR102C VPS25 Component of the ESCRT-II complex which is involved in ubiquitin-dependent sorting of proteins into the endosome; ESCRT-II subunit protein VPS25 495056 9487387 KLLA0_E05501g Kluyveromyces lactis ESCRT-II subunit protein VPS25 XP_002999396.1 494499 R 28985 CDS KLLA0_E05523g 2893703 495340..495831 E 1 NC_006041.1 similar to uniprot|Q12262 Saccharomyces cerevisiae YPR046W MCM16 Protein involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; uncharacterized protein 495831 2893703 KLLA0_E05523g Kluyveromyces lactis uncharacterized protein XP_454195.1 495340 D 28985 CDS KLLA0_E05545g 2893842 496271..498007 E 1 NC_006041.1 highly similar to uniprot|P28274 Saccharomyces cerevisiae YBL039C; uncharacterized protein 498007 2893842 KLLA0_E05545g Kluyveromyces lactis uncharacterized protein XP_454196.1 496271 D 28985 CDS KLLA0_E05567g 2893843 complement(498639..499106) E 1 NC_006041.1 highly similar to uniprot|P00445 Saccharomyces cerevisiae YJR104C SOD1 Cu Zn superoxide dismutase some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; superoxide dismutase SOD1 499106 2893843 KLLA0_E05567g Kluyveromyces lactis superoxide dismutase SOD1 XP_454197.1 498639 R 28985 CDS KLLA0_E05589g 2893844 500522..501631 E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 501631 2893844 KLLA0_E05589g Kluyveromyces lactis uncharacterized protein XP_454198.1 500522 D 28985 CDS KLLA0_E05611g 2894129 join(501887..501911,502069..502703) E 1 NC_006041.1 similar to uniprot|P18414 Saccharomyces cerevisiae YBL040C ERD2 Integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum has a role in maintenance of normal levels of ER-resident proteins; uncharacterized protein 502703 2894129 KLLA0_E05611g Kluyveromyces lactis uncharacterized protein XP_454199.1 501887 D 28985 CDS KLLA0_E05633g 2893612 complement(502868..503590) E 1 NC_006041.1 highly similar to uniprot|P23724 Saccharomyces cerevisiae YBL041W PRE7 20S proteasome beta-type subunit; proteasome core particle subunit beta 6 503590 2893612 KLLA0_E05633g Kluyveromyces lactis proteasome core particle subunit beta 6 XP_454200.1 502868 R 28985 CDS KLLA0_E05655g 2893741 complement(503859..505592) E 1 NC_006041.1 similar to uniprot|P27614 Saccharomyces cerevisiae YJL172W CPS1 Vacuolar carboxypeptidase yscS expression is induced under low-nitrogen conditions; uncharacterized protein 505592 2893741 KLLA0_E05655g Kluyveromyces lactis uncharacterized protein XP_454201.1 503859 R 28985 CDS KLLA0_E05677g 2894733 complement(506394..507089) E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 507089 2894733 KLLA0_E05677g Kluyveromyces lactis uncharacterized protein XP_454202.1 506394 R 28985 CDS KLLA0_E05699g 2893765 509158..510495 E 1 NC_006041.1 similar to uniprot|P07256 Saccharomyces cerevisiae YBL045C COR1 Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex) which is a component of the mitochondrial inner membrane electron transport chain; ubiquinol--cytochrome-c reductase subunit COR1 510495 2893765 KLLA0_E05699g Kluyveromyces lactis ubiquinol--cytochrome-c reductase subunit COR1 XP_454203.1 509158 D 28985 CDS KLLA0_E05721g 2893683 complement(511336..512544) E 1 NC_006041.1 some similarities with uniprot|P38193 Saccharomyces cerevisiae YBL046W Hypothetical ORF; uncharacterized protein 512544 2893683 KLLA0_E05721g Kluyveromyces lactis uncharacterized protein XP_454204.1 511336 R 28985 CDS KLLA0_E05743g 2893684 513485..514279 E 1 NC_006041.1 similar to uniprot|P47150 Saccharomyces cerevisiae YJR113C RSM7 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein uS7m 514279 2893684 KLLA0_E05743g Kluyveromyces lactis mitochondrial 37S ribosomal protein uS7m XP_454205.1 513485 D 28985 CDS KLLA0_E05765g 2894048 complement(514352..514798) E 1 NC_006041.1 similar to uniprot|Q3E743 Saccharomyces cerevisiae YJR112W-A; uncharacterized protein 514798 2894048 KLLA0_E05765g Kluyveromyces lactis uncharacterized protein XP_454206.1 514352 R 28985 CDS KLLA0_E05787g 2894664 515081..518767 E 1 NC_006041.1 weakly similar to uniprot|P34216 Saccharomyces cerevisiae YBL047C EDE1 Key endocytic protein involved in a network of interactions with other endocytic proteins binds membranes in a ubiquitin-dependent manner may also bind ubiquitinated membrane-associated proteins; uncharacterized protein 518767 2894664 KLLA0_E05787g Kluyveromyces lactis uncharacterized protein XP_454207.1 515081 D 28985 CDS KLLA0_E05809g 2893701 complement(518890..519507) E 1 NC_006041.1 similar to uniprot|P47149 Saccharomyces cerevisiae YJR112W NNF1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules required for accurate chromosome segregation; MIND complex subunit NNF1 519507 2893701 KLLA0_E05809g Kluyveromyces lactis MIND complex subunit NNF1 XP_454208.1 518890 R 28985 CDS KLLA0_E05831g 9487463 519783..520610 E 1 NC_006041.1 similar to uniprot|P47148 Saccharomyces cerevisiae YJR111C Hypothetical ORF; uncharacterized protein 520610 9487463 KLLA0_E05831g Kluyveromyces lactis uncharacterized protein XP_002999397.1 519783 D 28985 CDS KLLA0_E05853g 2894017 complement(520702..522591) E 1 NC_006041.1 similar to uniprot|P47147 Saccharomyces cerevisiae YJR110W YMR1 Phosphatidylinositol 3-phosphate; phosphatidylinositol-3-phosphatase YMR1 522591 2894017 KLLA0_E05853g Kluyveromyces lactis phosphatidylinositol-3-phosphatase YMR1 XP_454210.1 520702 R 28985 CDS KLLA0_E05875g 2894211 complement(523476..523850) E 1 NC_006041.1 similar to uniprot|P38191 Saccharomyces cerevisiae YBL049W MOH1; uncharacterized protein 523850 2894211 KLLA0_E05875g Kluyveromyces lactis uncharacterized protein XP_454211.1 523476 R 28985 CDS KLLA0_E05897g 2893804 complement(525092..527233) E 1 NC_006041.1 weakly similar to uniprot|Q08905 Saccharomyces cerevisiae YOR381W FRE3 Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; uncharacterized protein 527233 2893804 KLLA0_E05897g Kluyveromyces lactis uncharacterized protein XP_454212.1 525092 R 28985 CDS KLLA0_E05919g 2894509 complement(join(530194..531042,531265..531294)) E 1 NC_006041.1 highly similar to uniprot|P32602 Saccharomyces cerevisiae YBL050W SEC17; uncharacterized protein 531294 2894509 KLLA0_E05919g Kluyveromyces lactis uncharacterized protein XP_454213.1 530194 R 28985 CDS KLLA0_E05941g 2894154 complement(join(531676..531952,532447..532448)) E 1 NC_006041.1 highly similar to uniprot|P49631 Saccharomyces cerevisiae YJR094W-A RPL43B Protein component of the large (60S) ribosomal subunit and highly similar to uniprot|P49631 Saccharomyces cerevisiae YPR043W RPL43A Protein component of the large (60S) ribosomal subunit; 60S ribosomal protein eL43 532448 2894154 KLLA0_E05941g Kluyveromyces lactis 60S ribosomal protein eL43 XP_454214.1 531676 R 28985 CDS KLLA0_E05963g 2894453 534222..534857 E 1 NC_006041.1 similar to uniprot|P21190 Saccharomyces cerevisiae YJR094C IME1 Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p; transcription factor IME1 534857 2894453 KLLA0_E05963g Kluyveromyces lactis transcription factor IME1 XP_454215.1 534222 D 28985 CDS KLLA0_E05985g 2894528 535755..536642 E 1 NC_006041.1 some similarities with uniprot|P45976 Saccharomyces cerevisiae YJR093C FIP1 Subunit of cleavage polyadenylation factor; cleavage polyadenylation factor subunit FIP1 536642 2894528 KLLA0_E05985g Kluyveromyces lactis cleavage polyadenylation factor subunit FIP1 XP_454216.1 535755 D 28985 CDS KLLA0_E06007g 2894529 complement(536856..540509) E 1 NC_006041.1 weakly similar to uniprot|P47136 Saccharomyces cerevisiae YJR092W BUD4 Protein involved in bud-site selection and required for axial budding pattern localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding potential Cdc28p substrate; uncharacterized protein 540509 2894529 KLLA0_E06007g Kluyveromyces lactis uncharacterized protein XP_454217.1 536856 R 28985 CDS KLLA0_E06029g 2894475 541992..545276 E 1 NC_006041.1 similar to uniprot|P47135 Saccharomyces cerevisiae YJR091C JSN1 Member of the Puf family of RNA-binding proteins and to uniprot|Q12221 Saccharomyces cerevisiae YPR042C PUF2 mRNA binding protein; uncharacterized protein 545276 2894475 KLLA0_E06029g Kluyveromyces lactis uncharacterized protein XP_454218.1 541992 D 28985 CDS KLLA0_E06051g 2894750 545879..549598 E 1 NC_006041.1 similar to uniprot|P24814 Saccharomyces cerevisiae YJR090C GRR1 F-box protein component of the SCF ubiquitin-ligase complex required for Cln1p and Cln2p degradation involved in carbon catabolite repression glucose-dependent divalent cation transport high-affinity glucose transport and morphogenesis; SCF ubiquitin ligase complex subunit GRR1 549598 2894750 KLLA0_E06051g Kluyveromyces lactis SCF ubiquitin ligase complex subunit GRR1 XP_454219.1 545879 D 28985 CDS KLLA0_E06073g 2894521 complement(549775..552111) E 1 NC_006041.1 some similarities with uniprot|P47134 Saccharomyces cerevisiae YJR089W BIR1 Protein involved in cell cycle regulation and chromosome segregation contains BIR (Baculovirus Inhibitor of apoptosis Repeat) domain; survivin 552111 2894521 KLLA0_E06073g Kluyveromyces lactis survivin XP_454220.1 549775 R 28985 CDS KLLA0_E06095g 2894146 complement(552686..553882) E 1 NC_006041.1 similar to uniprot|P38431 Saccharomyces cerevisiae YPR041W TIF5 eIF5 mediates hydrolysis of eIF2-GTP (SUI2 SUI3 GCD11) at start codons Translation initiation factor eIF-5; translation initiation factor eIF5 553882 2894146 KLLA0_E06095g Kluyveromyces lactis translation initiation factor eIF5 XP_454221.1 552686 R 28985 CDS KLLA0_E06117g 2894147 554413..555273 E 1 NC_006041.1 similar to uniprot|P47133 Saccharomyces cerevisiae YJR088C Hypothetical ORF; uncharacterized protein 555273 2894147 KLLA0_E06117g Kluyveromyces lactis uncharacterized protein XP_454222.1 554413 D 28985 CDS KLLA0_E06139g 2894561 complement(555427..556638) E 1 NC_006041.1 similar to uniprot|Q12199 Saccharomyces cerevisiae YPR040W TIP41 Protein involved in regulation of the TOR pathway; uncharacterized protein 556638 2894561 KLLA0_E06139g Kluyveromyces lactis uncharacterized protein XP_454223.1 555427 R 28985 CDS KLLA0_E06161g 2894092 557120..557731 E 1 NC_006041.1 similar to uniprot|Q12284 Saccharomyces cerevisiae YPR037C ERV2 Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen involved in disulfide bond formation within the ER; flavin-linked sulfhydryl oxidase 557731 2894092 KLLA0_E06161g Kluyveromyces lactis flavin-linked sulfhydryl oxidase XP_454224.1 557120 D 28985 CDS KLLA0_E06183g 2894097 complement(557869..558141) E 1 NC_006041.1 similar to uniprot|P18852 Saccharomyces cerevisiae YJR086W STE18 G protein gamma subunit forms a dimer with Ste4p to activate the mating signaling pathway forms a heterotrimer with Gpa1p and Ste4p to dampen signaling C-terminus is palmitoylated and farnesylated which are required for normal signaling; uncharacterized protein 558141 2894097 KLLA0_E06183g Kluyveromyces lactis uncharacterized protein XP_454225.1 557869 R 28985 CDS KLLA0_E06205g 2894102 558694..559011 E 1 NC_006041.1 similar to uniprot|P47131 Saccharomyces cerevisiae YJR085C Hypothetical ORF; uncharacterized protein 559011 2894102 KLLA0_E06205g Kluyveromyces lactis uncharacterized protein XP_454227.1 558694 D 28985 CDS KLLA0_E06227g 2894104 complement(560535..561809) E 1 NC_006041.1 weakly similar to uniprot|P47130 Saccharomyces cerevisiae YJR084W CSN12 Subunit of the Cop9 signalosome which is required for deneddylation or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin) involved in adaptation to pheromone signaling; uncharacterized protein 561809 2894104 KLLA0_E06227g Kluyveromyces lactis uncharacterized protein XP_454228.1 560535 R 28985 CDS KLLA0_E06249g 2894106 562140..562781 E 1 NC_006041.1 some similarities with uniprot|P47129 Saccharomyces cerevisiae YJR083C ACF4 Protein of unknown function computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization potential Cdc28p substrate; uncharacterized protein 562781 2894106 KLLA0_E06249g Kluyveromyces lactis uncharacterized protein XP_454229.1 562140 D 28985 CDS KLLA0_E06271g 2894108 complement(562886..564268) E 1 NC_006041.1 similar to uniprot|P41807 Saccharomyces cerevisiae YPR036W VMA13 vacuolar ATPase V1 domain subunit H (54 kDa); H(+)-transporting V1 sector ATPase subunit H 564268 2894108 KLLA0_E06271g Kluyveromyces lactis H(+)-transporting V1 sector ATPase subunit H XP_454230.1 562886 R 28985 CDS KLLA0_E06293g 2894685 complement(564871..565989) E 1 NC_006041.1 highly similar to uniprot|P32288 Saccharomyces cerevisiae YPR035W GLN1 Glutamine synthetase (GS) synthesizes glutamine from glutamate and ammonia with Glt1p forms the secondary pathway for glutamate biosynthesis from ammonia expression regulated by nitrogen source and by amino acid limitation; glutamate--ammonia ligase 565989 2894685 KLLA0_E06293g Kluyveromyces lactis glutamate--ammonia ligase XP_454231.1 564871 R 28985 CDS KLLA0_E06315g 2894686 complement(567309..568625) E 1 NC_006041.1 similar to uniprot|Q75BT7 Ashbya gossypii ACR184C ACR184Cp and weakly similar to uniprot|Q12406 Saccharomyces cerevisiae YPR034W ARP7 Actin-related protein involved in transcriptional regulation subunit of the chromatin remodeling Snf/Swi complex; uncharacterized protein 568625 2894686 KLLA0_E06315g Kluyveromyces lactis uncharacterized protein XP_454232.1 567309 R 28985 CDS KLLA0_E06337g 2894485 569076..569423 E 1 NC_006041.1 some similarities with uniprot|P47128 Saccharomyces cerevisiae YJR082C EAF6 Esa1p-associated factor subunit of the NuA4 acetyltransferase complex; uncharacterized protein 569423 2894485 KLLA0_E06337g Kluyveromyces lactis uncharacterized protein XP_454233.1 569076 D 28985 CDS KLLA0_E06359g 2893754 570159..571193 E 1 NC_006041.1 weakly similar to uniprot|P47127 Saccharomyces cerevisiae YJR080C FMP26 The authentic non-tagged protein was localized to the mitochondria; uncharacterized protein 571193 2893754 KLLA0_E06359g Kluyveromyces lactis uncharacterized protein XP_454234.1 570159 D 28985 CDS KLLA0_E06381g 2893788 571704..573293 E 1 NC_006041.1 highly similar to uniprot|P07263 Saccharomyces cerevisiae YPR033C HTS1 Cytoplasmic and mitochondrial histidine tRNA synthetase encoded by a single nuclear gene that specifies two messages efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; histidine--tRNA ligase 573293 2893788 KLLA0_E06381g Kluyveromyces lactis histidine--tRNA ligase XP_454235.1 571704 D 28985 CDS KLLA0_E06403g 2893781 complement(573381..573974) E 1 NC_006041.1 similar to uniprot|P38162 Saccharomyces cerevisiae YBL107C Hypothetical ORF; uncharacterized protein 573974 2893781 KLLA0_E06403g Kluyveromyces lactis uncharacterized protein XP_454236.1 573381 R 28985 CDS KLLA0_E06425g 2893782 complement(574273..577239) E 1 NC_006041.1 similar to uniprot|Q12038 Saccharomyces cerevisiae YPR032W SRO7 Suppressor of rho3 yeast homolog of the Drosphila tumor suppressor lethal giant larvae or similar to YBL106C uniprot|P38163 Saccharomyces cerevisiae YBL106C SRO77 Suppressor of defect in the small GTPase Rho3p yeast homolog of the Drosphila tumor suppressor lethal giant larvae; Rab GTPase-binding protein SRO7 577239 2893782 KLLA0_E06425g Kluyveromyces lactis Rab GTPase-binding protein SRO7 XP_454237.1 574273 R 28985 CDS KLLA0_E06447g 2894083 complement(577669..581154) E 1 NC_006041.1 uniprot|Q8J213 Kluyveromyces lactis KLLA0E06413g PKC1 Protein kinase C; protein kinase C 581154 2894083 KLLA0_E06447g Kluyveromyces lactis protein kinase C XP_454238.1 577669 R 28985 CDS KLLA0_E06469g 2893916 complement(581935..584832) E 1 NC_006041.1 similar to uniprot|P38164 Saccharomyces cerevisiae YBL104C Hypothetical ORF; uncharacterized protein 584832 2893916 KLLA0_E06469g Kluyveromyces lactis uncharacterized protein XP_454239.1 581935 R 28985 CDS KLLA0_E06491g 2893665 complement(585024..587207) E 1 NC_006041.1 similar to uniprot|Q12311 Saccharomyces cerevisiae YPR031W NTO1 Component of the histone acetyltransferase complex; uncharacterized protein 587207 2893665 KLLA0_E06491g Kluyveromyces lactis uncharacterized protein XP_454240.1 585024 R 28985 CDS KLLA0_E06513g 2893614 complement(587745..589223) E 1 NC_006041.1 weakly similar to uniprot|P38165 Saccharomyces cerevisiae YBL103C RTG3 Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein Rtg1p to activate the retrograde (RTG) and TOR pathways; uncharacterized protein 589223 2893614 KLLA0_E06513g Kluyveromyces lactis uncharacterized protein XP_454241.1 587745 R 28985 CDS KLLA0_E06535g 2893615 589706..590347 E 1 NC_006041.1 highly similar to uniprot|P38166 Saccharomyces cerevisiae YBL102W; uncharacterized protein 590347 2893615 KLLA0_E06535g Kluyveromyces lactis uncharacterized protein XP_454242.1 589706 D 28985 CDS KLLA0_E06557g 2893667 complement(590423..593785) E 1 NC_006041.1 some similarities with uniprot|P38167 Saccharomyces cerevisiae YBL101C ECM21 Non-essential protein of unknown function promoter contains several Gcn4p binding elements; uncharacterized protein 593785 2893667 KLLA0_E06557g Kluyveromyces lactis uncharacterized protein XP_454244.1 590423 R 28985 CDS KLLA0_E06579g 2893871 594361..596763 E 1 NC_006041.1 similar to uniprot|Q12028 Saccharomyces cerevisiae YPR029C APL4 Gamma-adaptin large subunit of the clathrin-associated protein (AP) complex; uncharacterized protein 596763 2893871 KLLA0_E06579g Kluyveromyces lactis uncharacterized protein XP_454245.1 594361 D 28985 CDS KLLA0_E06601g 2893873 complement(join(596942..597433,597536..597586)) E 1 NC_006041.1 similar to uniprot|Q12402 Saccharomyces cerevisiae YPR028W YOP1 Protein that regulates vesicular traffic in stressed cells either to facilitate membrane turnover or to decrease unnecessary secretion; uncharacterized protein 597586 2893873 KLLA0_E06601g Kluyveromyces lactis uncharacterized protein XP_454246.1 596942 R 28985 CDS KLLA0_E06645g 2893876 complement(598212..601655) E 1 NC_006041.1 similar to uniprot|P48016 Saccharomyces cerevisiae YPR026W ATH1 Vacuolar acid trehalase required for trehalose utilization; alpha,alpha-trehalase ATH1 601655 2893876 KLLA0_E06645g Kluyveromyces lactis alpha,alpha-trehalase ATH1 XP_454247.1 598212 R 28985 CDS KLLA0_E06667g 2894293 603277..604923 E 1 NC_006041.1 highly similar to uniprot|P07251 Saccharomyces cerevisiae YBL099W ATP1 Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis; F1F0 ATP synthase subunit alpha 604923 2894293 KLLA0_E06667g Kluyveromyces lactis F1F0 ATP synthase subunit alpha XP_454248.1 603277 D 28985 CDS KLLA0_E06689g 2893669 605566..606762 E 1 NC_006041.1 similar to uniprot|P37366 Saccharomyces cerevisiae YPR025C CCL1 Cyclin associated with protein kinase Kin28p which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters; TFIIH complex kinase subunit CCL1 606762 2893669 KLLA0_E06689g Kluyveromyces lactis TFIIH complex kinase subunit CCL1 XP_454249.1 605566 D 28985 CDS KLLA0_E06711g 2893671 complement(607187..609496) E 1 NC_006041.1 highly similar to uniprot|P32795 Saccharomyces cerevisiae YPR024W YME1 Mitochondrial inner membrane protease of the AAA family responsible for degradation of unfolded or misfolded mitochondrial gene products mutation causes an elevated rate of mitochondrial turnover; i-AAA protease YME1 609496 2893671 KLLA0_E06711g Kluyveromyces lactis i-AAA protease YME1 XP_454250.1 607187 R 28985 CDS KLLA0_E06733g 2893674 complement(609924..612242) E 1 NC_006041.1 similar to uniprot|P38170 Saccharomyces cerevisiae YBL097W BRN1 Essential protein required for chromosome condensation likely to function as an intrinsic component of the condensation machinery may influence multiple aspects of chromosome transmission and dynamics; condensin subunit BRN1 612242 2893674 KLLA0_E06733g Kluyveromyces lactis condensin subunit BRN1 XP_454252.1 609924 R 28985 CDS KLLA0_E06755g 2893676 complement(612941..614944) E 1 NC_006041.1 weakly similar to uniprot|P30606 Saccharomyces cerevisiae YOL103W ITR2 Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively; uncharacterized protein 614944 2893676 KLLA0_E06755g Kluyveromyces lactis uncharacterized protein XP_454253.1 612941 R 28985 CDS KLLA0_E06777g 2893845 616703..617452 E 1 NC_006041.1 similar to uniprot|P38172 Saccharomyces cerevisiae YBL095W Hypothetical ORF; uncharacterized protein 617452 2893845 KLLA0_E06777g Kluyveromyces lactis uncharacterized protein XP_454254.1 616703 D 28985 CDS KLLA0_E06799g 2893847 618131..619678 E 1 NC_006041.1 similar to uniprot|P38682 Saccharomyces cerevisiae YER122C; ADP-ribosylation factor GTPase-activating protein 619678 2893847 KLLA0_E06799g Kluyveromyces lactis ADP-ribosylation factor GTPase-activating protein XP_454255.1 618131 D 28985 CDS KLLA0_E06821g 2893848 complement(620417..621037) E 1 NC_006041.1 similar to uniprot|P25046 Saccharomyces cerevisiae YBL093C ROX3 RNA polymerase II holoenzyme component; uncharacterized protein 621037 2893848 KLLA0_E06821g Kluyveromyces lactis uncharacterized protein XP_454256.1 620417 R 28985 CDS KLLA0_E06843g 2893851 622701..623093 E 1 NC_006041.1 highly similar to uniprot|P38061 Saccharomyces cerevisiae YBL092W RPL32 Protein component of the large (60S) ribosomal subunit has similarity to rat L32 ribosomal protein; 60S ribosomal protein eL32 623093 2893851 KLLA0_E06843g Kluyveromyces lactis 60S ribosomal protein eL32 XP_454257.1 622701 D 28985 CDS KLLA0_E06865g 2893613 complement(624007..624831) E 1 NC_006041.1 similar to uniprot|P40075 Saccharomyces cerevisiae YER120W SCS2 Protein likely to be involved in regulating INO1 expression suppressor of a dominant nuclear mutation that is inositol-dependent in the presence of choline involved in inositol metabolism regulator of INO1 expression; phospholipid metabolism-regulating protein SCS22 624831 2893613 KLLA0_E06865g Kluyveromyces lactis phospholipid metabolism-regulating protein SCS22 XP_454258.1 624007 R 28985 CDS KLLA0_E06887g 2893912 complement(625608..626864) E 1 NC_006041.1 similar to uniprot|P38174 Saccharomyces cerevisiae YBL091C MAP2 Methionine aminopeptidase catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides function is partially redundant with that of Map1p; methionine aminopeptidase 626864 2893912 KLLA0_E06887g Kluyveromyces lactis methionine aminopeptidase XP_454259.1 625608 R 28985 CDS KLLA0_E06909g 2893809 627257..627721 E 1 NC_006041.1 similar to gnl|GLV|CAGL0H04565g Candida glabrata CAGL0H04565g and some similarites with YBL090W uniprot|P38175 Saccharomyces cerevisiae YBL090W MRP21 Mitochondrial ribosomal protein of the large subunit MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences; mitochondrial 37S ribosomal protein bS21m 627721 2893809 KLLA0_E06909g Kluyveromyces lactis mitochondrial 37S ribosomal protein bS21m XP_454260.1 627257 D 28985 CDS KLLA0_E06931g 2893810 628083..629453 E 1 NC_006041.1 similar to uniprot|P40074 Saccharomyces cerevisiae YER119C AVT6 Vacuolar transporter exports aspartate and glutamate from the vacuole and to YBL089W uniprot|P38176 Saccharomyces cerevisiae YBL089W AVT5 Putative transporter, members of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; amino acid transporter 629453 2893810 KLLA0_E06931g Kluyveromyces lactis amino acid transporter XP_454261.1 628083 D 28985 CDS KLLA0_E06953g 2893914 629777..630850 E 1 NC_006041.1 uniprot|Q9P863 Kluyveromyces lactis sho1 Putative membrane protein; osmosensor SHO1 630850 2893914 KLLA0_E06953g Kluyveromyces lactis osmosensor SHO1 XP_454262.1 629777 D 28985 CDS KLLA0_E06975g 2893812 complement(631154..639439) E 1 NC_006041.1 similar to uniprot|P38110 Saccharomyces cerevisiae YBL088C TEL1 Protein kinase primarily involved in telomere length regulation contributes to cell cycle checkpoint control in response to DNA damage functionally redundant with Mec1p homolog of human ataxia telangiectasia (ATM) gene; DNA-binding protein kinase TEL1 639439 2893812 KLLA0_E06975g Kluyveromyces lactis DNA-binding protein kinase TEL1 XP_454263.1 631154 R 28985 CDS KLLA0_E06997g 2893815 complement(join(639749..640120,640630..640671)) E 1 NC_006041.1 highly similar to uniprot|P04451 Saccharomyces cerevisiae YER117W RPL23B Protein and highly similar to uniprot|P04451 Saccharomyces cerevisiae YBL087C RPL23A Protein, components of the large (60S) ribosomal subunit; 60S ribosomal protein uL14 640671 2893815 KLLA0_E06997g Kluyveromyces lactis 60S ribosomal protein uL14 XP_454264.1 639749 R 28985 CDS KLLA0_E07019g 2893817 641391..642230 E 1 NC_006041.1 some similarities with uniprot|P40072 Saccharomyces cerevisiae YER116C SLX8 Protein containing a RING finger domain that forms a complex with Hex3p mutant phenotypes and genetic interactions suggest a possible role in resolving recombination intermediates during DNA replication or repair; SUMO-targeted ubiquitin ligase complex subunit SLX8 642230 2893817 KLLA0_E07019g Kluyveromyces lactis SUMO-targeted ubiquitin ligase complex subunit SLX8 XP_454265.1 641391 D 28985 CDS KLLA0_E07041g 2893818 642499..643074 E 1 NC_006041.1 some similarities with YER115c; uncharacterized protein 643074 2893818 KLLA0_E07041g Kluyveromyces lactis uncharacterized protein XP_454266.1 642499 D 28985 CDS KLLA0_E07063g 2893822 643888..645369 E 1 NC_006041.1 similar to uniprot|Q6B229 Saccharomyces cerevisiae YOL137W BSC6 Protein of unknown function containing 8 putative transmembrane seqments ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; uncharacterized protein 645369 2893822 KLLA0_E07063g Kluyveromyces lactis uncharacterized protein XP_454267.1 643888 D 28985 CDS KLLA0_E07085g 2893820 645766..647124 E 1 NC_006041.1 similar to uniprot|P42841 Saccharomyces cerevisiae YNL317W PFS2 Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex; cleavage polyadenylation factor subunit PFS2 647124 2893820 KLLA0_E07085g Kluyveromyces lactis cleavage polyadenylation factor subunit PFS2 XP_454268.1 645766 D 28985 CDS KLLA0_E07107g 2893824 complement(647517..648884) E 1 NC_006041.1 similar to uniprot|Q75AV3 Ashbya gossypii ADL183C ADL183Cp and weakly similar to YOL136C uniprot|Q12471 Saccharomyces cerevisiae YOL136C PFK27 6-phosphofructo-2-kinase has negligible fructose-2 6-bisphosphatase activity inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate expression induced by glucose and sucrose transcriptional regulation involves protein kinase A; 6-phosphofructo-2-kinase 648884 2893824 KLLA0_E07107g Kluyveromyces lactis 6-phosphofructo-2-kinase XP_454269.1 647517 R 28985 CDS KLLA0_E07129g 2893835 complement(650256..650897) E 1 NC_006041.1 similar to uniprot|Q08278 Saccharomyces cerevisiae YOL135C; mediator complex subunit MED7 650897 2893835 KLLA0_E07129g Kluyveromyces lactis mediator complex subunit MED7 XP_454270.1 650256 R 28985 CDS KLLA0_E07151g 2893836 651474..651806 E 1 NC_006041.1 similar to uniprot|Q08273 Saccharomyces cerevisiae YOL133W HRT1 RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF) required for Gic2p Far1p Sic1p and Cln2p degradation may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF; SCF ubiquitin ligase complex subunit HRT1 651806 2893836 KLLA0_E07151g Kluyveromyces lactis SCF ubiquitin ligase complex subunit HRT1 XP_454271.1 651474 D 28985 CDS KLLA0_E07173g 2893838 complement(652155..653090) E 1 NC_006041.1 similar to uniprot|P32452 Saccharomyces cerevisiae YNL316C PHA2 Prephenate dehydratase catalyzes the conversion of prephanate to phenylpyruvate which is a step in the phenylalanine biosynthesis pathway; prephenate dehydratase PHA2 653090 2893838 KLLA0_E07173g Kluyveromyces lactis prephenate dehydratase PHA2 XP_454272.1 652155 R 28985 CDS KLLA0_E07195g 2893634 complement(653477..654433) E 1 NC_006041.1 similar to uniprot|P32453 Saccharomyces cerevisiae YNL315C ATP11 Molecular chaperone required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; uncharacterized protein 654433 2893634 KLLA0_E07195g Kluyveromyces lactis uncharacterized protein XP_454273.1 653477 R 28985 CDS KLLA0_E07217g 2893700 654790..655617 E 1 NC_006041.1 some similarities with uniprot|P21705 Saccharomyces cerevisiae YNL314W DAL82 Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain; uncharacterized protein 655617 2893700 KLLA0_E07217g Kluyveromyces lactis uncharacterized protein XP_454274.1 654790 D 28985 CDS KLLA0_E07239g 2893621 complement(655635..658325) E 1 NC_006041.1 similar to uniprot|P42842 Saccharomyces cerevisiae YNL313C Protein required for cell viability; tetratricopeptide repeat-containing protein EMW1 658325 2893621 KLLA0_E07239g Kluyveromyces lactis tetratricopeptide repeat-containing protein EMW1 XP_454275.1 655635 R 28985 CDS KLLA0_E07261g 2893622 complement(658638..660974) E 1 NC_006041.1 similar to uniprot|Q08269 Saccharomyces cerevisiae YOL130W ALR1 Plasma membrane Mg(2+) transporter expression and turnover are regulated by Mg(2+) concentration overexpression confers increased tolerance to Al(3+) and Ga(3+) ions and similar to YFL050C uniprot|P43553 Saccharomyces cerevisiae YFL050C ALR2 Probable Mg(2+)transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; Mg(2+) transporter ALR1 660974 2893622 KLLA0_E07261g Kluyveromyces lactis Mg(2+) transporter ALR1 XP_454276.1 658638 R 28985 CDS KLLA0_E07283g 2893626 complement(661677..662738) E 1 NC_006041.1 weakly similar to uniprot|P42845 Saccharomyces cerevisiae YNL309W STB1 Protein with a role in regulation of MBF-specific transcription at Start phosphorylated by Cln-Cdc28p kinases in vitro unphosphorylated form binds Swi6p and binding is required for Stb1p function expression is cell-cycle regulated; uncharacterized protein 662738 2893626 KLLA0_E07283g Kluyveromyces lactis uncharacterized protein XP_454277.1 661677 R 28985 CDS KLLA0_E07305g 2893624 663162..663737 E 1 NC_006041.1 similar to uniprot|P42844 Saccharomyces cerevisiae YNL310C ZIM17 Essential component of the mitochondrial import system zinc finger protein that may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix; uncharacterized protein 663737 2893624 KLLA0_E07305g Kluyveromyces lactis uncharacterized protein XP_454278.1 663162 D 28985 CDS KLLA0_E07327g 2894069 664145..666142 E 1 NC_006041.1 similar to uniprot|P42843 Saccharomyces cerevisiae YNL311C F-box protein; uncharacterized protein 666142 2894069 KLLA0_E07327g Kluyveromyces lactis uncharacterized protein XP_454279.1 664145 D 28985 CDS KLLA0_E07349g 2894064 complement(666129..667541) E 1 NC_006041.1 similar to uniprot|Q08271 Saccharomyces cerevisiae YOL132W GAS4 Putative 1,3-beta-glucanosyltransferase has similarity to Gas1p localizes to the cell wall; 1,3-beta-glucanosyltransferase 667541 2894064 KLLA0_E07349g Kluyveromyces lactis 1,3-beta-glucanosyltransferase XP_454280.1 666129 R 28985 CDS KLLA0_E07371g 9487284 complement(667907..668590) E 1 NC_006041.1 similar to uniprot|P26754 Saccharomyces cerevisiae YNL312W RFA2 Subunit of heterotrimeric Replication Factor A (RF-A) which is a highly conserved single-stranded DNA binding protein involved in DNA replication repair and recombination; uncharacterized protein 668590 9487284 KLLA0_E07371g Kluyveromyces lactis uncharacterized protein XP_002999398.1 667907 R 28985 CDS KLLA0_E07393g 2894071 complement(669201..670967) E 1 NC_006041.1 similar to uniprot|P42846 Saccharomyces cerevisiae YNL308C KRI1 Essential nucleolar protein required for 40S ribosome biogenesis physically and functionally interacts with Krr1p; uncharacterized protein 670967 2894071 KLLA0_E07393g Kluyveromyces lactis uncharacterized protein XP_454282.1 669201 R 28985 CDS KLLA0_E07415g 2894073 671600..672130 E 1 NC_006041.1 similar to uniprot|Q12016 Saccharomyces cerevisiae YOL129W VPS68; uncharacterized protein 672130 2894073 KLLA0_E07415g Kluyveromyces lactis uncharacterized protein XP_454283.1 671600 D 28985 CDS KLLA0_E07437g 2894075 complement(672690..673787) E 1 NC_006041.1 highly similar to uniprot|P21965 Saccharomyces cerevisiae YNL307C MCK1 Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis related to mammalian glycogen synthase kinases of the GSK-3 family; serine/threonine/tyrosine protein kinase MCK1 673787 2894075 KLLA0_E07437g Kluyveromyces lactis serine/threonine/tyrosine protein kinase MCK1 XP_454284.1 672690 R 28985 CDS KLLA0_E07459g 2894077 675010..675627 E 1 NC_006041.1 similar to uniprot|P42847 Saccharomyces cerevisiae YNL306W MRPS18 Mitochondrial ribosomal protein of the small subunit essential for viability unlike most other mitoribosomal proteins; mitochondrial 37S ribosomal protein YmS18 675627 2894077 KLLA0_E07459g Kluyveromyces lactis mitochondrial 37S ribosomal protein YmS18 XP_454285.1 675010 D 28985 CDS KLLA0_E07481g 2894080 join(676406..676418,677034..677449) E 1 NC_006041.1 highly similar to uniprot|P04456 Saccharomyces cerevisiae YOL127W Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit; 60S ribosomal protein uL23 677449 2894080 KLLA0_E07481g Kluyveromyces lactis 60S ribosomal protein uL23 XP_454286.1 676406 D 28985 CDS KLLA0_E07503g 2894081 complement(677690..678442) E 1 NC_006041.1 similar to uniprot|P48558 Saccharomyces cerevisiae YNL305C Hypothetical ORF; uncharacterized protein 678442 2894081 KLLA0_E07503g Kluyveromyces lactis uncharacterized protein XP_454287.1 677690 R 28985 CDS KLLA0_E07525g 2894086 complement(678882..680096) E 1 NC_006041.1 similar to uniprot|P22133 Saccharomyces cerevisiae YOL126C MDH2 Cytoplasmic malate dehydrogenase catalyzes interconversion of malate and oxaloacetate involved in gluconeogenesis and glyoxylate cycle; malate dehydrogenase MDH2 680096 2894086 KLLA0_E07525g Kluyveromyces lactis malate dehydrogenase MDH2 XP_454288.1 678882 R 28985 CDS KLLA0_E07547g 2894089 681586..682890 E 1 NC_006041.1 similar to uniprot|Q12383 Saccharomyces cerevisiae YOL125W Hypothetical ORF; tRNA:m4X modification enzyme 682890 2894089 KLLA0_E07547g Kluyveromyces lactis tRNA:m4X modification enzyme XP_454289.1 681586 D 28985 CDS KLLA0_E07569g 2894094 684098..685183 E 1 NC_006041.1 highly similar to uniprot|P14540 Saccharomyces cerevisiae YKL060C FBA1 Fructose 1 6-bisphosphate aldolase required for glycolysis and gluconeogenesis; fructose-bisphosphate aldolase FBA1 685183 2894094 KLLA0_E07569g Kluyveromyces lactis fructose-bisphosphate aldolase FBA1 XP_454290.1 684098 D 28985 CDS KLLA0_E07591g 2894095 685564..686559 E 1 NC_006041.1 similar to uniprot|Q75DF9 Ashbya gossypii ABR067C ABR067Cp and weakly similar to YMR026C uniprot|Q04370 Saccharomyces cerevisiae YMR026C PEX12 RING-finger peroxisomal membrane peroxin that plays an essential role in peroxisome biogenesis and peroxisomal matrix protein import forms translocation subcomplex with Pex2p and Pex10p; ubiquitin-protein ligase peroxin 12 686559 2894095 KLLA0_E07591g Kluyveromyces lactis ubiquitin-protein ligase peroxin 12 XP_454291.1 685564 D 28985 CDS KLLA0_E07613g 2894096 complement(686610..687218) E 1 NC_006041.1 no similarity; uncharacterized protein 687218 2894096 KLLA0_E07613g Kluyveromyces lactis uncharacterized protein XP_454292.1 686610 R 28985 CDS KLLA0_E07635g 2894100 complement(687442..688389) E 1 NC_006041.1 similar to uniprot|P36516 Saccharomyces cerevisiae YMR024W MRPL3 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein mL44 688389 2894100 KLLA0_E07635g Kluyveromyces lactis mitochondrial 54S ribosomal protein mL44 XP_454293.1 687442 R 28985 CDS KLLA0_E07657g 2894111 688734..690239 E 1 NC_006041.1 similar to uniprot|P32559 Saccharomyces cerevisiae YMR023C; uncharacterized protein 690239 2894111 KLLA0_E07657g Kluyveromyces lactis uncharacterized protein XP_454294.1 688734 D 28985 CDS KLLA0_E07679g 2893833 complement(690201..690515) E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 690515 2893833 KLLA0_E07679g Kluyveromyces lactis uncharacterized protein XP_454295.1 690201 R 28985 CDS KLLA0_E07701g 2894054 690760..691908 E 1 NC_006041.1 weakly similar to uniprot|P36090 Saccharomyces cerevisiae YKL047W Hypothetical ORF; uncharacterized protein 691908 2894054 KLLA0_E07701g Kluyveromyces lactis uncharacterized protein XP_454296.1 690760 D 28985 CDS KLLA0_E07723g 2894055 complement(691980..693332) E 1 NC_006041.1 similar to uniprot|P36091 Saccharomyces cerevisiae YKL046C DCW1 Mannosidase GPI-anchored membrane protein required for cell wall biosynthesis homologous to Dfg5p; uncharacterized protein 693332 2894055 KLLA0_E07723g Kluyveromyces lactis uncharacterized protein XP_454297.1 691980 R 28985 CDS KLLA0_E07745g 2893908 complement(693694..694191) E 1 NC_006041.1 highly similar to uniprot|Q02159 Saccharomyces cerevisiae YMR022W QRI8 Ubiquitin conjugating enzyme involved in the ER-associated protein degradation pathway requires Cue1p for recruitment to the ER membrane proposed to be involved in chromatin assembly; E2 ubiquitin-conjugating protein UBC7 694191 2893908 KLLA0_E07745g Kluyveromyces lactis E2 ubiquitin-conjugating protein UBC7 XP_454298.1 693694 R 28985 CDS KLLA0_E07767g 2894189 694992..696401 E 1 NC_006041.1 similar to uniprot|P35192 Saccharomyces cerevisiae YMR021C MAC1 Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport; uncharacterized protein 696401 2894189 KLLA0_E07767g Kluyveromyces lactis uncharacterized protein XP_454299.1 694992 D 28985 CDS KLLA0_E07789g 9487447 complement(696382..697887) E 1 NC_006041.1 similar to uniprot|P50264 Saccharomyces cerevisiae YMR020W FMS1 Polyamine oxidase converts spermine to spermidine which is required for the essential hypusination modification of translation factor eIF-5A also involved in pantothenic acid biosynthesis; polyamine oxidase 697887 9487447 KLLA0_E07789g Kluyveromyces lactis polyamine oxidase XP_002999399.1 696382 R 28985 CDS KLLA0_E07811g 2894225 699154..700626 E 1 NC_006041.1 some similarities with uniprot|P40463 Saccharomyces cerevisiae YIL135C VHS2 Gene whose overexpression suppresses the synthetic lethality of the hal3 sit4 double mutation; uncharacterized protein 700626 2894225 KLLA0_E07811g Kluyveromyces lactis uncharacterized protein XP_454301.1 699154 D 28985 CDS KLLA0_E07833g 2894226 complement(701193..702044) E 1 NC_006041.1 highly similar to uniprot|P53941 Saccharomyces cerevisiae YNL075W IMP4 Component of the SSU processome which is required for pre-18S rRNA processing interacts with Mpp10p member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs; snoRNA-binding rRNA-processing protein IMP4 702044 2894226 KLLA0_E07833g Kluyveromyces lactis snoRNA-binding rRNA-processing protein IMP4 XP_454302.1 701193 R 28985 CDS KLLA0_E07855g 2894142 complement(702486..704480) E 1 NC_006041.1 weakly similar to uniprot|P34072 Saccharomyces cerevisiae YNL076W MKS1 Pleiotropic regulatory factor involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation involved in retrograde (RTG) mitochondria-to-nucleus signaling; uncharacterized protein 704480 2894142 KLLA0_E07855g Kluyveromyces lactis uncharacterized protein XP_454303.1 702486 R 28985 CDS KLLA0_E07877g 2893991 complement(705849..707534) E 1 NC_006041.1 weakly similar to uniprot|P16547 Saccharomyces cerevisiae YIL136W OM45 Protein of unknown function major constituent of the mitochondrial outer membrane located on the outer (cytosolic) face of the outer membrane; uncharacterized protein 707534 2893991 KLLA0_E07877g Kluyveromyces lactis uncharacterized protein XP_454305.1 705849 R 28985 CDS KLLA0_E07899g 2894036 complement(709306..710793) E 1 NC_006041.1 similar to gnl|GLV|CAGL0J10296g Candida glabrata CAGL0J10296g and weakly similar to YNL077W uniprot|P53940 Saccharomyces cerevisiae YNL077W APJ1 Putative chaperone of the HSP40 (DNAJ) family overexpression interferes with propagation of the [Psi ] prion; uncharacterized protein 710793 2894036 KLLA0_E07899g Kluyveromyces lactis uncharacterized protein XP_454306.1 709306 R 28985 CDS KLLA0_E07921g 2894037 712370..715057 E 1 NC_006041.1 similar to uniprot|P40462 Saccharomyces cerevisiae YIL137C RBF108 Hypothetical ORF; uncharacterized protein 715057 2894037 KLLA0_E07921g Kluyveromyces lactis uncharacterized protein XP_454307.1 712370 D 28985 CDS KLLA0_E07943g 2894234 complement(715185..716660) E 1 NC_006041.1 weakly similar to uniprot|P53939 Saccharomyces cerevisiae YNL078W NIS1 Protein localized in the bud neck at G2/M phase physically interacts with septins possibly involved in a mitotic signaling network; uncharacterized protein 716660 2894234 KLLA0_E07943g Kluyveromyces lactis uncharacterized protein XP_454308.1 715185 R 28985 CDS KLLA0_E07965g 2893679 717476..718648 E 1 NC_006041.1 similar to uniprot|P20484 Saccharomyces cerevisiae YKL021C MAK11 Protein essential for cell growth and replication of M dsRNA virus contains four beta-transducin repeats; uncharacterized protein 718648 2893679 KLLA0_E07965g Kluyveromyces lactis uncharacterized protein XP_454309.1 717476 D 28985 CDS KLLA0_E07987g 2893882 complement(718820..719938) E 1 NC_006041.1 similar to uniprot|P38998 Saccharomyces cerevisiae YIR034C LYS1 Saccharopine dehydrogenase (NAD L-lysine-forming) catalyzes the conversion of saccharopine to L-lysine which is the final step in the lysine biosynthesis pathway; saccharopine dehydrogenase (NAD+, L-lysine-forming) 719938 2893882 KLLA0_E07987g Kluyveromyces lactis saccharopine dehydrogenase (NAD+, L-lysine-forming) XP_454310.1 718820 R 28985 CDS KLLA0_E08009g 2893899 720700..722865 E 1 NC_006041.1 similar to uniprot|P09798 Saccharomyces cerevisiae YKL022C CDC16 Subunit of the anaphase-promoting complex/cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition required for sporulation; anaphase promoting complex subunit CDC16 722865 2893899 KLLA0_E08009g Kluyveromyces lactis anaphase promoting complex subunit CDC16 XP_454311.1 720700 D 28985 CDS KLLA0_E08031g 2893900 complement(722953..724179) E 1 NC_006041.1 no similarity; uncharacterized protein 724179 2893900 KLLA0_E08031g Kluyveromyces lactis uncharacterized protein XP_454312.1 722953 R 28985 CDS KLLA0_E08053g 2893662 complement(724562..725470) E 1 NC_006041.1 highly similar to uniprot|P15700 Saccharomyces cerevisiae YKL024C URA6; bifunctional uridylate/adenylate kinase 725470 2893662 KLLA0_E08053g Kluyveromyces lactis bifunctional uridylate/adenylate kinase XP_454313.1 724562 R 28985 CDS KLLA0_E08075g 9487345 complement(join(725895..726251,726361..726792)) E 1 NC_006041.1 similar to uniprot|P40580 Saccharomyces cerevisiae YIR036C IRC24 and to uniprot|P40579 Saccharomyces cerevisiae YIR035C; uncharacterized protein 726792 9487345 KLLA0_E08075g Kluyveromyces lactis uncharacterized protein XP_002999400.1 725895 R 28985 CDS KLLA0_E08097g 2894263 727056..729026 E 1 NC_006041.1 similar to uniprot|P36102 Saccharomyces cerevisiae YKL025C PAN3 Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes; uncharacterized protein 729026 2894263 KLLA0_E08097g Kluyveromyces lactis uncharacterized protein XP_454316.1 727056 D 28985 CDS KLLA0_E08119g 2894264 730334..735823 E 1 NC_006041.1 highly similar to uniprot|P32528 Saccharomyces cerevisiae YBR208C DUR1 2 Urea amidolyase contains both urea carboxylase and allophanate hydrolase activities degrades urea to CO2 and NH3 expression sensitive to nitrogen catabolite repression and induced by allophanate an intermediate in allantoin degradation; bifunctional urea carboxylase/allophanate hydrolase 735823 2894264 KLLA0_E08119g Kluyveromyces lactis bifunctional urea carboxylase/allophanate hydrolase XP_454317.1 730334 D 28985 CDS KLLA0_E08141g 2894267 complement(736008..737117) E 1 NC_006041.1 weakly similar to uniprot|P28496 Saccharomyces cerevisiae YKL008C LAC1 Ceramide synthase component involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine functionally equivalent to Lag1p and similar to YHL003C uniprot|P38703 Saccharomyces cerevisiae YHL003C LAG1 Ceramide synthase component involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine functionally equivalent to Lac1p; uncharacterized protein 737117 2894267 KLLA0_E08141g Kluyveromyces lactis uncharacterized protein XP_454318.1 736008 R 28985 CDS KLLA0_E08163g 2894296 complement(737811..738725) E 1 NC_006041.1 similar to uniprot|P47821 Saccharomyces cerevisiae YNL025C SSN8 Component of RNA polymerase II holoenzyme involved in RNA pol II carboxy-terminal domain phosphorylation; cyclin-dependent protein serine/threonine kinase regulator SSN8 738725 2894296 KLLA0_E08163g Kluyveromyces lactis cyclin-dependent protein serine/threonine kinase regulator SSN8 XP_454319.1 737811 R 28985 CDS KLLA0_E08207g 2894728 complement(740213..741673) E 1 NC_006041.1 similar to uniprot|P40499 Saccharomyces cerevisiae YIL090W ICE2 Integral ER membrane protein with type-III transmembrane domains mutations cause defects in cortical ER morphology in both the mother and daughter cells; uncharacterized protein 741673 2894728 KLLA0_E08207g Kluyveromyces lactis uncharacterized protein XP_454320.1 740213 R 28985 CDS KLLA0_E08229g 2894532 742066..744180 E 1 NC_006041.1 similar to uniprot|P40498 Saccharomyces cerevisiae YIL091C Protein required for cell viability; rRNA-binding ribosome biosynthesis protein UTP25 744180 2894532 KLLA0_E08229g Kluyveromyces lactis rRNA-binding ribosome biosynthesis protein UTP25 XP_454321.1 742066 D 28985 CDS KLLA0_E08251g 2894533 complement(744523..744741) E 1 NC_006041.1 highly similar to uniprot|Q8TGJ3 Saccharomyces cerevisiae YNL024C-A Identified by gene-trapping microarray-based expression analysis and genome-wide homology searching; uncharacterized protein 744741 2894533 KLLA0_E08251g Kluyveromyces lactis uncharacterized protein XP_454322.1 744523 R 28985 CDS KLLA0_E08273g 2893987 745145..745930 E 1 NC_006041.1 similar to uniprot|P40496 Saccharomyces cerevisiae YIL093C RSM25 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein mS23 745930 2893987 KLLA0_E08273g Kluyveromyces lactis mitochondrial 37S ribosomal protein mS23 XP_454323.1 745145 D 28985 CDS KLLA0_E08295g 2894119 complement(746166..746966) E 1 NC_006041.1 similar to uniprot|P53970 Saccharomyces cerevisiae YNL024C Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; uncharacterized protein 746966 2894119 KLLA0_E08295g Kluyveromyces lactis uncharacterized protein XP_454324.1 746166 R 28985 CDS KLLA0_E08317g 2893958 complement(747272..750037) E 1 NC_006041.1 similar to uniprot|P53971 Saccharomyces cerevisiae YNL023C; uncharacterized protein 750037 2893958 KLLA0_E08317g Kluyveromyces lactis uncharacterized protein XP_454325.1 747272 R 28985 CDS KLLA0_E08339g 2894444 750670..751779 E 1 NC_006041.1 highly similar to uniprot|P40495 Saccharomyces cerevisiae YIL094C LYS12 Homo-isocitrate dehydrogenase an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate; homoisocitrate dehydrogenase 751779 2894444 KLLA0_E08339g Kluyveromyces lactis homoisocitrate dehydrogenase XP_454326.1 750670 D 28985 CDS KLLA0_E08361g 2894445 complement(751889..753364) E 1 NC_006041.1 similar to uniprot|P53972 Saccharomyces cerevisiae YNL022C; rRNA (cytosine-C5-)-methyltransferase RCM1 753364 2894445 KLLA0_E08361g Kluyveromyces lactis rRNA (cytosine-C5-)-methyltransferase RCM1 XP_454327.1 751889 R 28985 CDS KLLA0_E08383g 2893681 754048..756162 E 1 NC_006041.1 highly similar to uniprot|P53973 Saccharomyces cerevisiae YNL021W HDA1 Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer deletion increases histone H2B H3 and H4 acetylation; histone deacetylase HDA1 756162 2893681 KLLA0_E08383g Kluyveromyces lactis histone deacetylase HDA1 XP_454328.1 754048 D 28985 CDS KLLA0_E08405g 2893708 complement(756205..758538) E 1 NC_006041.1 similar to uniprot|P40494 Saccharomyces cerevisiae YIL095W PRK1 Protein serine/threonine kinase regulates the organization and function of the actin cytoskeleton through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; uncharacterized protein 758538 2893708 KLLA0_E08405g Kluyveromyces lactis uncharacterized protein XP_454329.1 756205 R 28985 CDS KLLA0_E08449g 2894052 759718..760986 E 1 NC_006041.1 similar to uniprot|P53962 Saccharomyces cerevisiae YNL035C Hypothetical ORF; uncharacterized protein 760986 2894052 KLLA0_E08449g Kluyveromyces lactis uncharacterized protein XP_454330.1 759718 D 28985 CDS KLLA0_E08471g 2893992 761242..762957 E 1 NC_006041.1 similar to uniprot|P46678 Saccharomyces cerevisiae YNL039W BDP1 Essential subunit of RNA polymerase III transcription factor (TFIIIB) which is involved in transcription of genes encoding tRNAs 5S rRNA U6 snRNA and other small RNAs; transcription factor TFIIIB subunit BDP1 762957 2893992 KLLA0_E08471g Kluyveromyces lactis transcription factor TFIIIB subunit BDP1 XP_454331.1 761242 D 28985 CDS KLLA0_E08493g 2894171 763184..763639 E 1 NC_006041.1 weakly similar to uniprot|P53961 Saccharomyces cerevisiae YNL038W GPI15 Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors homologous to the human PIG-H protein; phosphatidylinositol N-acetylglucosaminyltransferase GPI15 763639 2894171 KLLA0_E08493g Kluyveromyces lactis phosphatidylinositol N-acetylglucosaminyltransferase GPI15 XP_454332.1 763184 D 28985 CDS KLLA0_E08515g 2893636 764002..764973 E 1 NC_006041.1 similar to uniprot|P40493 Saccharomyces cerevisiae YIL096C Hypothetical ORF; 25S rRNA (uracil2634-N3)-methyltransferase 764973 2893636 KLLA0_E08515g Kluyveromyces lactis 25S rRNA (uracil2634-N3)-methyltransferase XP_454333.1 764002 D 28985 CDS KLLA0_E08537g 2893637 complement(764998..766404) E 1 NC_006041.1 similar to uniprot|P40492 Saccharomyces cerevisiae YIL097W FYV10 Protein of unknown function required for survival upon exposure to K1 killer toxin involved in proteasome-dependent catabolite inactivation of fructose-1 6-bisphosphatase contains CTLH domain; glucose-induced degradation complex subunit FYV10 766404 2893637 KLLA0_E08537g Kluyveromyces lactis glucose-induced degradation complex subunit FYV10 XP_454334.1 764998 R 28985 CDS KLLA0_E08559g 2893906 complement(766878..768260) E 1 NC_006041.1 similar to uniprot|P40501 Saccharomyces cerevisiae YIL088C AVT7 Putative transporter member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; uncharacterized protein 768260 2893906 KLLA0_E08559g Kluyveromyces lactis uncharacterized protein XP_454335.1 766878 R 28985 CDS KLLA0_E08581g 2893722 768795..769619 E 1 NC_006041.1 similar to uniprot|P53965 Saccharomyces cerevisiae YNL032W SIW14 Tyrosine phosphatase that plays a role in actin filament organization and endocytosis localized to the cytoplasm; uncharacterized protein 769619 2893722 KLLA0_E08581g Kluyveromyces lactis uncharacterized protein XP_454336.1 768795 D 28985 CDS KLLA0_E08603g 2893688 complement(769789..770283) E 1 NC_006041.1 similar to uniprot|P40502 Saccharomyces cerevisiae YIL087C Hypothetical ORF; uncharacterized protein 770283 2893688 KLLA0_E08603g Kluyveromyces lactis uncharacterized protein XP_454337.1 769789 R 28985 CDS KLLA0_E08625g 2893884 complement(770773..771303) E 1 NC_006041.1 highly similar to uniprot|P02303 Saccharomyces cerevisiae YNL031C HHT2 and highly similar to uniprot|P02303 Saccharomyces cerevisiae YBR010W HHT1 histone H3 proteins; histone H3 771303 2893884 KLLA0_E08625g Kluyveromyces lactis histone H3 XP_454338.1 770773 R 28985 CDS KLLA0_E08647g 2894115 772323..772634 E 1 NC_006041.1 highly similar to uniprot|P02309 YBR009C and to uniprot|P02309 YNL030W Saccharomyces cerevisiae, HHF1 and HHF2, two identical histone H4 proteins; core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity; histone H4 772634 2894115 KLLA0_E08647g Kluyveromyces lactis histone H4 XP_454743.1 772323 D 28985 CDS KLLA0_E08669g 2893638 complement(773082..774650) E 1 NC_006041.1 similar to uniprot|P53966 Saccharomyces cerevisiae YNL029C KTR5 Putative mannosyltransferase involved in protein glycosylation member of the KRE2/MNT1 mannosyltransferase family; uncharacterized protein 774650 2893638 KLLA0_E08669g Kluyveromyces lactis uncharacterized protein XP_454340.1 773082 R 28985 CDS KLLA0_E08691g 2894058 complement(775085..776044) E 1 NC_006041.1 similar to uniprot|P40505 Saccharomyces cerevisiae YIL084C; uncharacterized protein 776044 2894058 KLLA0_E08691g Kluyveromyces lactis uncharacterized protein XP_454341.1 775085 R 28985 CDS KLLA0_E08713g 2894688 777005..778795 E 1 NC_006041.1 some similarities with uniprot|P53968 Saccharomyces cerevisiae YNL027W CRZ1 Transcription factor that activates transcription of genes involved in stress response nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; DNA-binding transcription factor CRZ1 778795 2894688 KLLA0_E08713g Kluyveromyces lactis DNA-binding transcription factor CRZ1 XP_454342.1 777005 D 28985 CDS KLLA0_E08735g 2894155 779165..780643 E 1 NC_006041.1 similar to uniprot|P53969 Saccharomyces cerevisiae YNL026W SAM50 Essential component of the Sorting and Assembly Machinery (SAM complex) of the mitochondrial outer membrane the authentic non-tagged protein was localized to the mitochondria; SAM complex subunit SAM50 780643 2894155 KLLA0_E08735g Kluyveromyces lactis SAM complex subunit SAM50 XP_454343.1 779165 D 28985 CDS KLLA0_E08757g 2894156 complement(780776..781831) E 1 NC_006041.1 highly similar to uniprot|P40506 Saccharomyces cerevisiae YIL083C Homolog to human PPCS; phosphopantothenate--cysteine ligase CAB2 781831 2894156 KLLA0_E08757g Kluyveromyces lactis phosphopantothenate--cysteine ligase CAB2 XP_454344.1 780776 R 28985 CDS KLLA0_E08779g 2894255 782800..784227 E 1 NC_006041.1 similar to uniprot|P32588 Saccharomyces cerevisiae YNL016W PUB1 Poly(A) RNA-binding protein abundant mRNP-component protein hypothesized to bind a pool of non-translatable mRNAs not reported to associate with polyribosomes; uncharacterized protein 784227 2894255 KLLA0_E08779g Kluyveromyces lactis uncharacterized protein XP_454345.1 782800 D 28985 CDS KLLA0_E08801g 2894228 784991..787306 E 1 NC_006041.1 similar to uniprot|P25037 Saccharomyces cerevisiae YDL122W UBP1 Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins cleaves at the C terminus of ubiquitin fusions irrespective of their size capable of cleaving polyubiquitin chains; ubiquitin-specific protease UBP1 787306 2894228 KLLA0_E08801g Kluyveromyces lactis ubiquitin-specific protease UBP1 XP_454346.1 784991 D 28985 CDS KLLA0_E08823g 2894203 complement(787451..787882) E 1 NC_006041.1 similar to uniprot|Q07541 Saccharomyces cerevisiae YDL121C Hypothetical ORF; uncharacterized protein 787882 2894203 KLLA0_E08823g Kluyveromyces lactis uncharacterized protein XP_454347.1 787451 R 28985 CDS KLLA0_E08845g 2894481 788296..788868 E 1 NC_006041.1 similar to uniprot|Q07540 Saccharomyces cerevisiae YDL120W YFH1 Yeast Frataxin Homologue mitochondrial protein that regulates mitochondrial iron accumulation; ferroxidase 788868 2894481 KLLA0_E08845g Kluyveromyces lactis ferroxidase XP_454348.1 788296 D 28985 CDS KLLA0_E08867g 2894482 789275..789505 E 1 NC_006041.1 similar to uniprot|P01095 Saccharomyces cerevisiae YNL015W PBI2 Cytosolic inhibitor of vacuolar proteinase B required for efficient vacuole inheritance with thioredoxin forms protein complex LMA1 which assists in priming SNARE molecules and promotes vacuole fusion; uncharacterized protein 789505 2894482 KLLA0_E08867g Kluyveromyces lactis uncharacterized protein XP_454349.1 789275 D 28985 CDS KLLA0_E08889g 2894689 789922..791007 E 1 NC_006041.1 similar to uniprot|P18898 Saccharomyces cerevisiae YGL155W CDC43 Beta subunit of geranylgeranyltransferase type I catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe has substrates important for morphogenesis; protein geranylgeranyltransferase type I subunit CDC43 791007 2894689 KLLA0_E08889g Kluyveromyces lactis protein geranylgeranyltransferase type I subunit CDC43 XP_454350.1 789922 D 28985 CDS KLLA0_E08911g 2894220 complement(791157..792041) E 1 NC_006041.1 similar to uniprot|Q07534 Saccharomyces cerevisiae YDL119C; uncharacterized protein 792041 2894220 KLLA0_E08911g Kluyveromyces lactis uncharacterized protein XP_454351.1 791157 R 28985 CDS KLLA0_E08933g 2893692 complement(792276..793067) E 1 NC_006041.1 weakly similar to uniprot|P50113 Saccharomyces cerevisiae YGL154C LYS5 Phosphopantetheinyl transferase involved in lysine biosynthesis converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine; holo-[acyl-carrier-protein] synthase 793067 2893692 KLLA0_E08933g Kluyveromyces lactis holo-[acyl-carrier-protein] synthase XP_454352.1 792276 R 28985 CDS KLLA0_E08955g 2893801 793287..794315 E 1 NC_006041.1 similar to uniprot|P53112 Saccharomyces cerevisiae YGL153W PEX14 Peroxisomal membrane protein that is a central component of the peroxisomal protein import machinery interacts with PTS1 (Pex5p) and PTS2 (Pex7p) peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p; uncharacterized protein 794315 2893801 KLLA0_E08955g Kluyveromyces lactis uncharacterized protein XP_454353.1 793287 D 28985 CDS KLLA0_E08977g 2893802 794616..797819 E 1 NC_006041.1 similar to uniprot|P53114 Saccharomyces cerevisiae YGL151W NUT1 Component of the RNA polymerase II mediator complex which is required for transcriptional activation and also has a role in basal transcription; uncharacterized protein 797819 2893802 KLLA0_E08977g Kluyveromyces lactis uncharacterized protein XP_454354.1 794616 D 28985 CDS KLLA0_E08999g 2893796 complement(797861..802330) E 1 NC_006041.1 similar to uniprot|P53115 Saccharomyces cerevisiae YGL150C ATPase that forms a large complex, containing actin and several actin-related proteins, that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; shows similarity to the Snf2p family of ATPases; chromatin-remodeling ATPase INO80 802330 2893796 KLLA0_E08999g Kluyveromyces lactis chromatin-remodeling ATPase INO80 XP_454355.1 797861 R 28985 CDS KLLA0_E09021g 2893840 804915..806615 E 1 NC_006041.1 uniprot|Q8NJ22 Kluyveromyces lactis KLLA0E08987g frt1 Hexose transporter; uncharacterized protein 806615 2893840 KLLA0_E09021g Kluyveromyces lactis uncharacterized protein XP_454356.1 804915 D 28985 CDS KLLA0_E09043g 2894222 complement(807159..809603) E 1 NC_006041.1 similar to uniprot|Q07533 Saccharomyces cerevisiae YDL117W CYK3 SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring mutant phenotype and genetic interactions suggest a role in cytokinesis; uncharacterized protein 809603 2894222 KLLA0_E09043g Kluyveromyces lactis uncharacterized protein XP_454357.1 807159 R 28985 CDS KLLA0_E09065g 2894237 complement(810338..811468) E 1 NC_006041.1 highly similar to uniprot|P28777 Saccharomyces cerevisiae YGL148W ARO2 Bifunctional chorismate synthase and flavin reductase catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate which is a precursor to aromatic amino acids; bifunctional chorismate synthase/riboflavin reductase [NAD(P)H] ARO2 811468 2894237 KLLA0_E09065g Kluyveromyces lactis bifunctional chorismate synthase/riboflavin reductase [NAD(P)H] ARO2 XP_454358.1 810338 R 28985 CDS KLLA0_E09087g 2894238 812175..814343 E 1 NC_006041.1 similar to uniprot|P52891 Saccharomyces cerevisiae YDL116W NUP84 Subunit of the nuclear pore complex (NPC) forms a subcomplex with Nup85p Nup120p Nup145p-C Sec13p and Seh1p that plays a role in nuclear mRNA export and NPC biogenesis; uncharacterized protein 814343 2894238 KLLA0_E09087g Kluyveromyces lactis uncharacterized protein XP_454359.1 812175 D 28985 CDS KLLA0_E09109g 2894230 complement(814476..815051) E 1 NC_006041.1 highly similar to uniprot|P05738 Saccharomyces cerevisiae uniprot|P05738 Saccharomyces cerevisiae YGL147C RPL9A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins and to YNL067W uniprot|P51401 Saccharomyces cerevisiae YNL067W RPL9B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins; 60S ribosomal protein uL6 815051 2894230 KLLA0_E09109g Kluyveromyces lactis 60S ribosomal protein uL6 XP_454360.1 814476 R 28985 CDS KLLA0_E09131g 2894530 complement(815506..816633) E 1 NC_006041.1 similar to uniprot|A2TBP4 Saccharomyces cerevisiae YDL115C IWR1 Protein of unknown function deletion causes hypersensitivity to the K1 killer toxin; uncharacterized protein 816633 2894530 KLLA0_E09131g Kluyveromyces lactis uncharacterized protein XP_454361.1 815506 R 28985 CDS KLLA0_E09153g 2894512 816861..817703 E 1 NC_006041.1 weakly similar to uniprot|Q07530 Saccharomyces cerevisiae YDL114W Hypothetical ORF; short-chain dehydrogenase/reductase 817703 2894512 KLLA0_E09153g Kluyveromyces lactis short-chain dehydrogenase/reductase XP_454362.1 816861 D 28985 CDS KLLA0_E09175g 2894747 complement(817829..819739) E 1 NC_006041.1 similar to uniprot|Q07528 Saccharomyces cerevisiae YDL113C ATG20 Protein required for transport of aminopeptidase I (Lap4p) through the cytoplasm-to-vacuole targeting pathway binds phosphatidylinositol-3-phosphate involved in localization of membranes to the preautophagosome potential Cdc28p substrate; uncharacterized protein 819739 2894747 KLLA0_E09175g Kluyveromyces lactis uncharacterized protein XP_454363.1 817829 R 28985 CDS KLLA0_E09197g 2894748 820095..824288 E 1 NC_006041.1 similar to uniprot|Q7LGS3 Saccharomyces cerevisiae YDL112W TRM3 2'-O-ribose methyltransferase catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs; tRNA (guanosine(18)-2'-O)-methyltransferase 824288 2894748 KLLA0_E09197g Kluyveromyces lactis tRNA (guanosine(18)-2'-O)-methyltransferase XP_454364.1 820095 D 28985 CDS KLLA0_E09219g 2893806 complement(824344..825138) E 1 NC_006041.1 similar to uniprot|Q12277 Saccharomyces cerevisiae YDL111C RRP42 Ribosomal RNA Processing Component of the exosome 3->5 exoribonuclease complex with Rrp4p Rrp41p Rrp43p and Dis3p (Rrp44p).; exosome non-catalytic core subunit RRP42 825138 2893806 KLLA0_E09219g Kluyveromyces lactis exosome non-catalytic core subunit RRP42 XP_454365.1 824344 R 28985 CDS KLLA0_E09241g 2894040 complement(825533..826306) E 1 NC_006041.1 weakly similar to uniprot|P53117 Saccharomyces cerevisiae YGL146C Hypothetical ORF; uncharacterized protein 826306 2894040 KLLA0_E09241g Kluyveromyces lactis uncharacterized protein XP_454366.1 825533 R 28985 CDS KLLA0_E09263g 2894205 complement(827035..827517) E 1 NC_006041.1 similar to uniprot|Q12513 Saccharomyces cerevisiae YDL110C Hypothetical ORF; uncharacterized protein 827517 2894205 KLLA0_E09263g Kluyveromyces lactis uncharacterized protein XP_454367.1 827035 R 28985 CDS KLLA0_E09285g 2894247 828244..829518 E 1 NC_006041.1 similar to uniprot|Q03338 Saccharomyces cerevisiae YDR473C PRP3 Splicing factor component of the U4/U6-U5 snRNP complex; U4/U6-U5 snRNP complex subunit PRP3 829518 2894247 KLLA0_E09285g Kluyveromyces lactis U4/U6-U5 snRNP complex subunit PRP3 XP_454368.1 828244 D 28985 CDS KLLA0_E09307g 2894248 complement(829846..830163) E 1 NC_006041.1 highly similar to uniprot|P38910 Saccharomyces cerevisiae YOR020C HSP10 Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p; uncharacterized protein 830163 2894248 KLLA0_E09307g Kluyveromyces lactis uncharacterized protein XP_454370.1 829846 R 28985 CDS KLLA0_E09329g 2894252 830886..831113 E 1 NC_006041.1 similar to uniprot|Q3E824 Saccharomyces cerevisiae YOR020W-A; uncharacterized protein 831113 2894252 KLLA0_E09329g Kluyveromyces lactis uncharacterized protein XP_454371.1 830886 D 28985 CDS KLLA0_E09351g 2894258 complement(831306..831944) E 1 NC_006041.1 highly similar to uniprot|Q12314 Saccharomyces cerevisiae YOR021C; protein-arginine N-methyltransferase SFM1 831944 2894258 KLLA0_E09351g Kluyveromyces lactis protein-arginine N-methyltransferase SFM1 XP_454372.1 831306 R 28985 CDS KLLA0_E09373g 2893798 complement(832187..834076) E 1 NC_006041.1 similar to uniprot|Q12204 Saccharomyces cerevisiae YOR022C Hypothetical ORF; uncharacterized protein 834076 2893798 KLLA0_E09373g Kluyveromyces lactis uncharacterized protein XP_454373.1 832187 R 28985 CDS KLLA0_E09395g 2893799 complement(834365..835711) E 1 NC_006041.1 weakly similar to uniprot|Q12433 Saccharomyces cerevisiae YOR023C AHC1 Ada Histone acetyltransferase complex component protein of the Ada histone acetyltransferase complex; uncharacterized protein 835711 2893799 KLLA0_E09395g Kluyveromyces lactis uncharacterized protein XP_454374.1 834365 R 28985 CDS KLLA0_E09417g 2894694 836226..836648 E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 836648 2894694 KLLA0_E09417g Kluyveromyces lactis uncharacterized protein XP_454375.1 836226 D 28985 CDS KLLA0_E09439g 2894765 complement(836948..837544) E 1 NC_006041.1 similar to uniprot|Q07915 Saccharomyces cerevisiae YLR009W RLP24 Ribosomal Like Protein 24; ATPase-activating ribosome biosynthesis protein 837544 2894765 KLLA0_E09439g Kluyveromyces lactis ATPase-activating ribosome biosynthesis protein XP_454376.1 836948 R 28985 CDS KLLA0_E09461g 2893862 838259..838750 E 1 NC_006041.1 similar to uniprot|Q07914 Saccharomyces cerevisiae YLR008C PAM18 Constituent of the mitochondrial import motor associated with the presequence translocase along with Ssc1p Tim44p Mge1p and Pam16p stimulates the ATPase activity of Ssc1p to drive mitochondrial import contains a J domain; uncharacterized protein 838750 2893862 KLLA0_E09461g Kluyveromyces lactis uncharacterized protein XP_454377.1 838259 D 28985 CDS KLLA0_E09483g 2894034 complement(838945..839916) E 1 NC_006041.1 weakly similar to uniprot|Q07913 Saccharomyces cerevisiae YLR007W NSE1 Essential nuclear protein required for DNA repair forms a complex with Smc5p and Rhc18p; Smc5-Smc6 complex subunit NSE1 839916 2894034 KLLA0_E09483g Kluyveromyces lactis Smc5-Smc6 complex subunit NSE1 XP_454378.1 838945 R 28985 CDS KLLA0_E09505g 2894035 840647..842554 E 1 NC_006041.1 weakly similar to uniprot|Q07084 Saccharomyces cerevisiae YLR006C SSK1 Cytoplasmic response regulator part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism dephosphorylated form is degraded by the ubiquitin-proteasome system potential Cdc28p substrate; mitogen-activated protein kinase kinase kinase SSK1 842554 2894035 KLLA0_E09505g Kluyveromyces lactis mitogen-activated protein kinase kinase kinase SSK1 XP_454379.1 840647 D 28985 CDS KLLA0_E09527g 2894764 843133..845223 E 1 NC_006041.1 similar to uniprot|P27351 Saccharomyces cerevisiae YJR005W APL1 beta-adaptin large subunit of the clathrin-associated protein complex; uncharacterized protein 845223 2894764 KLLA0_E09527g Kluyveromyces lactis uncharacterized protein XP_454380.1 843133 D 28985 CDS KLLA0_E09549g 2893893 complement(845298..846224) E 1 NC_006041.1 similar to uniprot|Q07897 Saccharomyces cerevisiae YLR003C CMS1 Hypothetical ORF; uncharacterized protein 846224 2893893 KLLA0_E09549g Kluyveromyces lactis uncharacterized protein XP_454381.1 845298 R 28985 CDS KLLA0_E09571g 2893710 complement(846600..848135) E 1 NC_006041.1 similar to uniprot|Q07904 Saccharomyces cerevisiae YLR004C Hypothetical ORF; uncharacterized protein 848135 2893710 KLLA0_E09571g Kluyveromyces lactis uncharacterized protein XP_454382.1 846600 R 28985 CDS KLLA0_E09593g 2893686 848785..851295 E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 851295 2893686 KLLA0_E09593g Kluyveromyces lactis uncharacterized protein XP_454383.1 848785 D 28985 CDS KLLA0_E09615g 2893687 851587..853053 E 1 NC_006041.1 similar to uniprot|Q04673 YLR005W Saccharomyces cerevisiae SSL1 Component of RNA polymerase transcription factor TFIIH; TFIIH/NER complex subunit SSL1 853053 2893687 KLLA0_E09615g Kluyveromyces lactis TFIIH/NER complex subunit SSL1 XP_454384.1 851587 D 28985 CDS KLLA0_E09637g 2893800 853845..855602 E 1 NC_006041.1 highly similar to uniprot|P53389 Saccharomyces cerevisiae YNR055C; uncharacterized protein 855602 2893800 KLLA0_E09637g Kluyveromyces lactis uncharacterized protein XP_454385.1 853845 D 28985 CDS KLLA0_E09681g 2894182 857611..859959 E 1 NC_006041.1 some similarities with uniprot|P20840 Saccharomyces cerevisiae YJR004C SAG1 Alpha-agglutinin of alpha-cells binds to Aga1p during agglutination N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin C-terminal half is highly glycosylated and contains GPI anchor; uncharacterized protein 859959 2894182 KLLA0_E09681g Kluyveromyces lactis uncharacterized protein XP_454386.1 857611 D 28985 CDS KLLA0_E09703g 2893620 complement(860245..861168) E 1 NC_006041.1 weakly similar to uniprot|P38087 Saccharomyces cerevisiae YBR104W Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p member vGLC.1420; uncharacterized protein 861168 2893620 KLLA0_E09703g Kluyveromyces lactis uncharacterized protein XP_454387.1 860245 R 28985 CDS KLLA0_E09725g 2894030 861812..862447 E 1 NC_006041.1 no similarity; uncharacterized protein 862447 2894030 KLLA0_E09725g Kluyveromyces lactis uncharacterized protein XP_454388.1 861812 D 28985 CDS KLLA0_E09747g 2893839 862612..862887 E 1 NC_006041.1 similar to uniprot|P46965 Saccharomyces cerevisiae YJR010C-A; signal peptidase complex subunit SPC1 862887 2893839 KLLA0_E09747g Kluyveromyces lactis signal peptidase complex subunit SPC1 XP_454389.1 862612 D 28985 CDS KLLA0_E09769g 2893660 863295..865037 E 1 NC_006041.1 similar to uniprot|P42826 Saccharomyces cerevisiae YGR194C XKS1 third enzyme in the xylose pathway, Xylulokinase; xylulokinase 865037 2893660 KLLA0_E09769g Kluyveromyces lactis xylulokinase XP_454390.1 863295 D 28985 CDS KLLA0_E09791g 2893661 865604..866821 E 1 NC_006041.1 similar to uniprot|P16451 Saccharomyces cerevisiae YGR193C PDX1 Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core; uncharacterized protein 866821 2893661 KLLA0_E09791g Kluyveromyces lactis uncharacterized protein XP_454391.1 865604 D 28985 CDS KLLA0_E09813g 2894144 867899..870139 E 1 NC_006041.1 similar to uniprot|P39106 Saccharomyces cerevisiae YER001W MNN1 Alpha-1 3-mannosyltransferase integral membrane glycoprotein of the Golgi complex required for addition of alpha1 3-mannose linkages to N-linked and O-linked oligosaccharides one of five S. cerevisiae proteins of the MNN1 family; uncharacterized protein 870139 2894144 KLLA0_E09813g Kluyveromyces lactis uncharacterized protein XP_454392.1 867899 D 28985 CDS KLLA0_E09835g 2894185 complement(870664..872172) E 1 NC_006041.1 highly similar to uniprot|P08536 Saccharomyces cerevisiae YJR010W MET3 ATP sulfurylase catalyzes the primary step of intracellular sulfate activation essential for assimilatory reduction of sulfate to sulfide involved in methionine metabolism; sulfate adenylyltransferase 872172 2894185 KLLA0_E09835g Kluyveromyces lactis sulfate adenylyltransferase XP_454393.1 870664 R 28985 CDS KLLA0_E09857g 2894536 complement(872888..873694) E 1 NC_006041.1 weakly similar to uniprot|Q05016 Saccharomyces cerevisiae YMR226C NADP()-dependent dehydrogenase acts on serine L-allo-threonine and other 3-hydroxy acids; uncharacterized protein 873694 2894536 KLLA0_E09857g Kluyveromyces lactis uncharacterized protein XP_454394.1 872888 R 28985 CDS KLLA0_E09879g 2894691 complement(874102..875994) E 1 NC_006041.1 similar to uniprot|P36172 Saccharomyces cerevisiae YKR105C Hypothetical ORF; uncharacterized protein 875994 2894691 KLLA0_E09879g Kluyveromyces lactis uncharacterized protein XP_454395.1 874102 R 28985 CDS KLLA0_E09901g 2894692 complement(877366..879048) E 1 NC_006041.1 some similarities with uniprot|P53729 Saccharomyces cerevisiae YNR029C Hypothetical ORF; uncharacterized protein 879048 2894692 KLLA0_E09901g Kluyveromyces lactis uncharacterized protein XP_454396.1 877366 R 28985 CDS KLLA0_E09923g 2893861 881665..883236 E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 883236 2893861 KLLA0_E09923g Kluyveromyces lactis uncharacterized protein XP_454397.1 881665 D 28985 CDS KLLA0_E09945g 2893627 complement(883778..884119) E 1 NC_006041.1 no similarity; uncharacterized protein 884119 2893627 KLLA0_E09945g Kluyveromyces lactis uncharacterized protein XP_454398.1 883778 R 28985 CDS KLLA0_E09967g 2893995 884414..885151 E 1 NC_006041.1 similar to uniprot|P35127 Saccharomyces cerevisiae YJR099W YUH1 Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin hydrolyzes the peptide bond at the C-terminus of ubiquitin also the major processing enzyme for the ubiquitin-like protein Rub1p; ubiquitin-specific protease YUH1 885151 2893995 KLLA0_E09967g Kluyveromyces lactis ubiquitin-specific protease YUH1 XP_454399.1 884414 D 28985 CDS KLLA0_E09989g 2894020 complement(885282..887150) E 1 NC_006041.1 weakly similar to uniprot|Q07109 Saccharomyces cerevisiae YPR045C Hypothetical ORF; uncharacterized protein 887150 2894020 KLLA0_E09989g Kluyveromyces lactis uncharacterized protein XP_454400.1 885282 R 28985 CDS KLLA0_E10011g 2894021 complement(887535..888464) E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 888464 2894021 KLLA0_E10011g Kluyveromyces lactis uncharacterized protein XP_454401.1 887535 R 28985 CDS KLLA0_E10033g 2894224 complement(888721..889626) E 1 NC_006041.1 similar to uniprot|P47140 Saccharomyces cerevisiae YJR100C Hypothetical ORF; uncharacterized protein 889626 2894224 KLLA0_E10033g Kluyveromyces lactis uncharacterized protein XP_454402.1 888721 R 28985 CDS KLLA0_E10055g 2893827 complement(890157..891083) E 1 NC_006041.1 highly similar to uniprot|P32345 Saccharomyces cerevisiae YDR075W PPH3 Catalytic subunit of protein phosphatase involved in activation of Gln3p which is a transcription factor with a role in nitrogen utilization; phosphoprotein phosphatase PP4 catalytic subunit PPH3 891083 2893827 KLLA0_E10055g Kluyveromyces lactis phosphoprotein phosphatase PP4 catalytic subunit PPH3 XP_454403.1 890157 R 28985 CDS KLLA0_E10077g 2893795 891885..892901 E 1 NC_006041.1 weakly similar to uniprot|Q70DD8 Saccharomyces cerevisiae YER149C PEA2 Coiled-coil polarisome protein; uncharacterized protein 892901 2893795 KLLA0_E10077g Kluyveromyces lactis uncharacterized protein XP_454404.1 891885 D 28985 CDS KLLA0_E10099g 2893858 complement(893271..893972) E 1 NC_006041.1 highly similar to uniprot|P13393 Saccharomyces cerevisiae YER148W SPT15 TATA-binding protein general transcription factor that interacts with other factors to form the preinitiation complex at promoters essential for viability; TATA-binding protein 893972 2893858 KLLA0_E10099g Kluyveromyces lactis TATA-binding protein XP_454405.1 893271 R 28985 CDS KLLA0_E10121g 2893859 894620..896509 E 1 NC_006041.1 similar to uniprot|P40090 Saccharomyces cerevisiae YER147C SCC4; cohesin-loading factor complex subunit SCC4 896509 2893859 KLLA0_E10121g Kluyveromyces lactis cohesin-loading factor complex subunit SCC4 XP_454406.1 894620 D 28985 CDS KLLA0_E10143g 2894138 complement(896599..899229) E 1 NC_006041.1 similar to uniprot|P31688 Saccharomyces cerevisiae YDR074W TPS2 Trehalose-6-phosphate phosphatase; trehalose-phosphatase TPS2 899229 2894138 KLLA0_E10143g Kluyveromyces lactis trehalose-phosphatase TPS2 XP_454407.1 896599 R 28985 CDS KLLA0_E10165g 2894139 complement(899751..900149) E 1 NC_006041.1 similar to gnl|GLV|CAGL0G05329g Candida glabrata CAGL0G05329g and some similarites with YDR073W uniprot|P38956 Saccharomyces cerevisiae YDR073W SNF11 component of SWI/SNF global transcription activator complex; uncharacterized protein 900149 2894139 KLLA0_E10165g Kluyveromyces lactis uncharacterized protein XP_454408.1 899751 R 28985 CDS KLLA0_E10187g 2894132 901353..902957 E 1 NC_006041.1 similar to uniprot|P38954 Saccharomyces cerevisiae YDR072C IPT1 Inositolphosphotransferase 1 involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C) which is the most abundant sphingolipid in cells mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media; inositolphosphotransferase 902957 2894132 KLLA0_E10187g Kluyveromyces lactis inositolphosphotransferase XP_454409.1 901353 D 28985 CDS KLLA0_E10209g 2894133 complement(903201..903455) E 1 NC_006041.1 similar to uniprot|P40089 Saccharomyces cerevisiae YER146W LSM5 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay; RNA-binding protein LSM5 903455 2894133 KLLA0_E10209g Kluyveromyces lactis RNA-binding protein LSM5 XP_454410.1 903201 R 28985 CDS KLLA0_E10231g 2894134 904368..904949 E 1 NC_006041.1 similar to uniprot|Q12447 Saccharomyces cerevisiae YDR071C PAA1 Polyamine acetyltransferase acetylates polyamines such as putrescine spermidine and spermine may be involved in transcription initiation; polyamine acetyltransferase 904949 2894134 KLLA0_E10231g Kluyveromyces lactis polyamine acetyltransferase XP_454411.1 904368 D 28985 CDS KLLA0_E10253g 2894135 905780..906052 E 1 NC_006041.1 similar to uniprot|Q12497 Saccharomyces cerevisiae YDR070C FMP16 The authentic, non-tagged protein was localized to the mitochondria; uncharacterized protein 906052 2894135 KLLA0_E10253g Kluyveromyces lactis uncharacterized protein XP_454412.1 905780 D 28985 CDS KLLA0_E10275g 2894137 906675..909065 E 1 NC_006041.1 similar to uniprot|P39944 Saccharomyces cerevisiae YER144C UBP5 Putative ubiquitin-specific protease that does not associate with the proteasome; uncharacterized protein 909065 2894137 KLLA0_E10275g Kluyveromyces lactis uncharacterized protein XP_454413.1 906675 D 28985 CDS KLLA0_E10297g 2894136 complement(909140..910015) E 1 NC_006041.1 weakly similar to uniprot|P54858 Saccharomyces cerevisiae YDR068W DOS2 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; uncharacterized protein 910015 2894136 KLLA0_E10297g Kluyveromyces lactis uncharacterized protein XP_454414.1 909140 R 28985 CDS KLLA0_E10319g 2893896 910343..911050 E 1 NC_006041.1 similar to uniprot|Q6Q559 Saccharomyces cerevisiae YDR067C which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; protein-tyrosine-phosphatase 911050 2893896 KLLA0_E10319g Kluyveromyces lactis protein-tyrosine-phosphatase XP_454415.1 910343 D 28985 CDS KLLA0_E10341g 2893897 complement(911148..912392) E 1 NC_006041.1 similar to uniprot|P40087 Saccharomyces cerevisiae YER143W DDI1 DNA damage-inducible v-SNARE binding protein contains a ubiquitin-associated (UBA) domain may act as a negative regulator of constitutive exocytosis may play a role in S-phase checkpoint control; uncharacterized protein 912392 2893897 KLLA0_E10341g Kluyveromyces lactis uncharacterized protein XP_454416.1 911148 R 28985 CDS KLLA0_E10363g 2894695 912583..913413 E 1 NC_006041.1 similar to uniprot|P22134 Saccharomyces cerevisiae YER142C MAG1 3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; DNA-3-methyladenine glycosylase II 913413 2894695 KLLA0_E10363g Kluyveromyces lactis DNA-3-methyladenine glycosylase II XP_454417.1 912583 D 28985 CDS KLLA0_E10385g 2894188 complement(913611..915095) E 1 NC_006041.1 similar to uniprot|P40086 Saccharomyces cerevisiae YER141W COX15 Protein required for the hydroxylation of heme O to form heme A which is an essential prosthetic group for cytochrome c oxidase; uncharacterized protein 915095 2894188 KLLA0_E10385g Kluyveromyces lactis uncharacterized protein XP_454418.1 913611 R 28985 CDS KLLA0_E10407g 2894249 complement(915551..918886) E 1 NC_006041.1 similar to uniprot|P36775 Saccharomyces cerevisiae YBL022C PIM1 Mitochondrial ATP-dependent protease involved in intramitochondrial proteolysis involved in degradation of misfolded proteins in mitochondria required for bigenesis and maintenance of mitochondria; ATP-dependent Lon protease PIM1 918886 2894249 KLLA0_E10407g Kluyveromyces lactis ATP-dependent Lon protease PIM1 XP_454420.1 915551 R 28985 CDS KLLA0_E10429g 2894288 complement(919489..920106) E 1 NC_006041.1 uniprot|P40914 Kluyveromyces lactis HAP3 Transcriptional activator HAP3; uncharacterized protein 920106 2894288 KLLA0_E10429g Kluyveromyces lactis uncharacterized protein XP_454421.1 919489 R 28985 CDS KLLA0_E10451g 2894284 920415..922085 E 1 NC_006041.1 similar to uniprot|P38206 Saccharomyces cerevisiae YBL020W RFT1 Flippase; glycolipid translocation protein 922085 2894284 KLLA0_E10451g Kluyveromyces lactis glycolipid translocation protein XP_454422.1 920415 D 28985 CDS KLLA0_E10473g 2894250 922357..923856 E 1 NC_006041.1 similar to uniprot|P38207 Saccharomyces cerevisiae YBL019W APN2 Class II abasic (AP) endonuclease involved in repair of DNA damage homolog of human HAP1 and E. coli exoIII; DNA-(apurinic or apyrimidinic site) lyase APN2 923856 2894250 KLLA0_E10473g Kluyveromyces lactis DNA-(apurinic or apyrimidinic site) lyase APN2 XP_454423.1 922357 D 28985 CDS KLLA0_E10495g 2894253 complement(923922..924338) E 1 NC_006041.1 similar to uniprot|P38208 Saccharomyces cerevisiae YBL018C POP8 Subunit of both RNase MRP which cleaves pre-rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends; ribonuclease P 924338 2894253 KLLA0_E10495g Kluyveromyces lactis ribonuclease P XP_454424.1 923922 R 28985 CDS KLLA0_E10517g 2894257 complement(924701..929401) E 1 NC_006041.1 similar to uniprot|P32319 Saccharomyces cerevisiae YBL017C PEP1 Type I transmembrane sorting receptor for multiple vacuolar hydrolases cycles between the late-Golgi and prevacuolar endosome-like compartments; type I sorting receptor 929401 2894257 KLLA0_E10517g Kluyveromyces lactis type I sorting receptor XP_454425.1 924701 R 28985 CDS KLLA0_E10539g 2894206 929989..931104 E 1 NC_006041.1 highly similar to uniprot|P16892 Saccharomyces cerevisiae YBL016W FUS3 Mitogen-activated protein kinase involved in mating pheromone response activated by phosphorylation by Ste7p provides specificity during the mating vs. filamentous growth response by phosphorylating transcriptional and cytoplasmic targets; mitogen-activated serine/threonine-protein kinase FUS3 931104 2894206 KLLA0_E10539g Kluyveromyces lactis mitogen-activated serine/threonine-protein kinase FUS3 XP_454426.1 929989 D 28985 CDS KLLA0_E10561g 2894510 932415..933986 E 1 NC_006041.1 highly similar to uniprot|P32316 Saccharomyces cerevisiae YBL015W ACH1 Acetyl-coA hydrolase primarily localized to mitochondria required for acetate utilization and for diploid pseudohyphal growth; acetyl-CoA hydrolase 933986 2894510 KLLA0_E10561g Kluyveromyces lactis acetyl-CoA hydrolase XP_454427.1 932415 D 28985 CDS KLLA0_E10583g 2894511 complement(934321..935421) E 1 NC_006041.1 similar to uniprot|P32785 Saccharomyces cerevisiae YBL013W FMT1 Methionyl-tRNA formyltransferase; methionyl-tRNA formyltransferase 935421 2894511 KLLA0_E10583g Kluyveromyces lactis methionyl-tRNA formyltransferase XP_454428.1 934321 R 28985 CDS KLLA0_E10605g 2894159 935625..936467 E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 936467 2894159 KLLA0_E10605g Kluyveromyces lactis uncharacterized protein XP_454429.1 935625 D 28985 CDS KLLA0_E10627g 2893658 936850..937806 E 1 NC_006041.1 some similarities with uniprot|P40356 Saccharomyces cerevisiae YGL025C PGD1 Subunit of the Mediator global transcriptional cofactor complex which is part of the RNA polymerase II holoenzyme and plays an essential role in basal and activated transcription direct target of the Cyc8p-Tup1p transcriptional corepressor; uncharacterized protein 937806 2893658 KLLA0_E10627g Kluyveromyces lactis uncharacterized protein XP_454430.1 936850 D 28985 CDS KLLA0_E10649g 2894014 938243..940372 E 1 NC_006041.1 highly similar to uniprot|P00931 Saccharomyces cerevisiae YGL026C TRP5 tryptophan synthetase; tryptophan synthase TRP5 940372 2894014 KLLA0_E10649g Kluyveromyces lactis tryptophan synthase TRP5 XP_454431.1 938243 D 28985 CDS KLLA0_E10671g 2894172 940776..943364 E 1 NC_006041.1 weakly similar to uniprot|P32786 Saccharomyces cerevisiae YBL014C RRN6 involved in the transcription of 35S rRNA genes by RNA polymerase I member of yeast Pol I core factor (CF) also composed of Rrn11p Rrn7p and TATA-binding protein; uncharacterized protein 943364 2894172 KLLA0_E10671g Kluyveromyces lactis uncharacterized protein XP_454432.1 940776 D 28985 CDS KLLA0_E10693g 2894173 943825..946281 E 1 NC_006041.1 similar to uniprot|P53008 Saccharomyces cerevisiae YGL027C CWH41 Processing alpha glucosidase I involved in assembly of cell wall beta 1 6 glucan and asparagine-linked protein glycosylation ER type II integral membrane N-glycoprotein disruption leads to a K1 killer toxin-resistant phenotype; mannosyl-oligosaccharide glucosidase 946281 2894173 KLLA0_E10693g Kluyveromyces lactis mannosyl-oligosaccharide glucosidase XP_454433.1 943825 D 28985 CDS KLLA0_E10715g 2893860 947393..948907 E 1 NC_006041.1 some similarities with uniprot|P53189 Saccharomyces cerevisiae YGL028C; uncharacterized protein 948907 2893860 KLLA0_E10715g Kluyveromyces lactis uncharacterized protein XP_454434.1 947393 D 28985 CDS KLLA0_E10737g 2893797 complement(949228..950184) E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 950184 2893797 KLLA0_E10737g Kluyveromyces lactis uncharacterized protein XP_454435.1 949228 R 28985 CDS KLLA0_E10781g 2893657 complement(950629..950994) E 1 NC_006041.1 similar to uniprot|P53188 Saccharomyces cerevisiae YGL029W CGR1 Coiled-coil protein that may contribute to compartmentalization of nucleolar constituents expression is growth-regulated; uncharacterized protein 950994 2893657 KLLA0_E10781g Kluyveromyces lactis uncharacterized protein XP_454436.1 950629 R 28985 CDS KLLA0_E10803g 2893680 951335..953896 E 1 NC_006041.1 similar to uniprot|P48237 Saccharomyces cerevisiae YGR150C Hypothetical ORF; uncharacterized protein 953896 2893680 KLLA0_E10803g Kluyveromyces lactis uncharacterized protein XP_454437.1 951335 D 28985 CDS KLLA0_E10825g 2893757 complement(954084..955310) E 1 NC_006041.1 similar to uniprot|P48236 Saccharomyces cerevisiae YGR149W Hypothetical ORF; glycerophosphocholine acyltransferase 955310 2893757 KLLA0_E10825g Kluyveromyces lactis glycerophosphocholine acyltransferase XP_454438.1 954084 R 28985 CDS KLLA0_E10847g 2894002 complement(join(955703..956017,956254..956256)) E 1 NC_006041.1 highly similar to uniprot|P14120 Saccharomyces cerevisiae YGL030W RPL30 Protein component of the large (60S) ribosomal subunit; 60S ribosomal protein eL30 956256 2894002 KLLA0_E10847g Kluyveromyces lactis 60S ribosomal protein eL30 XP_454439.1 955703 R 28985 CDS KLLA0_E10869g 2894273 957487..957954 E 1 NC_006041.1 similar to uniprot|P04449 Saccharomyces cerevisiae YGL031C RPL24A and to uniprot|P24000 Saccharomyces cerevisiae YGR148C RPL24B; 60S ribosomal protein eL24 957954 2894273 KLLA0_E10869g Kluyveromyces lactis 60S ribosomal protein eL24 XP_454440.1 957487 D 28985 CDS KLLA0_E10891g 9487443 958672..958944 E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 958944 9487443 KLLA0_E10891g Kluyveromyces lactis uncharacterized protein XP_002999401.1 958672 D 28985 CDS KLLA0_E10913g 2894028 959536..960201 E 1 NC_006041.1 similar to gnl|GLV|CAGL0E03003g Candida glabrata CAGL0E03003g and weakly similar to YGR147C uniprot|P37293 Saccharomyces cerevisiae YGR147C NAT2 N alpha-acetyl-transferase transfers acetyl group from acetyl coenzyme A to the N-terminal methionine residues of proteins; uncharacterized protein 960201 2894028 KLLA0_E10913g Kluyveromyces lactis uncharacterized protein XP_454441.1 959536 D 28985 CDS KLLA0_E10935g 2894029 complement(960404..961330) E 1 NC_006041.1 similar to uniprot|P78609 Pichia jadinii Uricase; uncharacterized protein 961330 2894029 KLLA0_E10935g Kluyveromyces lactis uncharacterized protein XP_454442.1 960404 R 28985 CDS KLLA0_E11001g 2894537 complement(964114..965010) E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 965010 2894537 KLLA0_E11001g Kluyveromyces lactis uncharacterized protein XP_454445.1 964114 R 28985 CDS KLLA0_E11023g 2894281 966805..968229 E 1 NC_006041.1 uniprot|P50898 Kluyveromyces lactis MIG1 Regulatory protein MIG1; transcription factor MIG1 968229 2894281 KLLA0_E11023g Kluyveromyces lactis transcription factor MIG1 XP_454446.1 966805 D 28985 CDS KLLA0_E11045g 2894484 968674..969972 E 1 NC_006041.1 similar to uniprot|P49960 Saccharomyces cerevisiae YMR268C PRP24 Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling; U6 snRNP complex subunit PRP24 969972 2894484 KLLA0_E11045g Kluyveromyces lactis U6 snRNP complex subunit PRP24 XP_454447.1 968674 D 28985 CDS KLLA0_E11067g 2894739 complement(969999..974819) E 1 NC_006041.1 similar to uniprot|P52593 Saccharomyces cerevisiae YML103C NUP188 Subunit of the nuclear pore complex (NPC); uncharacterized protein 974819 2894739 KLLA0_E11067g Kluyveromyces lactis uncharacterized protein XP_454448.1 969999 R 28985 CDS KLLA0_E11089g 2894740 complement(975074..975967) E 1 NC_006041.1 similar to uniprot|P28239 Saccharomyces cerevisiae YMR267W PPA2 Mitochondrial inorganic pyrophosphatase required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate; inorganic diphosphatase PPA2 975967 2894740 KLLA0_E11089g Kluyveromyces lactis inorganic diphosphatase PPA2 XP_454449.1 975074 R 28985 CDS KLLA0_E11111g 2894693 complement(976184..978910) E 1 NC_006041.1 similar to uniprot|Q03516 Saccharomyces cerevisiae YMR266W RSN1 Overexpression rescues sro7/sop1 in NaCl. Encodes a membrane protein.; uncharacterized protein 978910 2894693 KLLA0_E11111g Kluyveromyces lactis uncharacterized protein XP_454450.1 976184 R 28985 CDS KLLA0_E11133g 2893764 979660..981042 E 1 NC_006041.1 some similarities with uniprot|Q03508 Saccharomyces cerevisiae YMR265C Hypothetical ORF; uncharacterized protein 981042 2893764 KLLA0_E11133g Kluyveromyces lactis uncharacterized protein XP_454451.1 979660 D 28985 CDS KLLA0_E11155g 2893721 981392..982696 E 1 NC_006041.1 some similarities with uniprot|Q03508 Saccharomyces cerevisiae YMR265C Hypothetical ORF; uncharacterized protein 982696 2893721 KLLA0_E11155g Kluyveromyces lactis uncharacterized protein XP_454452.1 981392 D 28985 CDS KLLA0_E11177g 2893772 983669..985150 E 1 NC_006041.1 similar to uniprot|Q04199 Saccharomyces cerevisiae YML102W CAC2 Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA required for building functional kinetochores conserved from yeast to humans; uncharacterized protein 985150 2893772 KLLA0_E11177g Kluyveromyces lactis uncharacterized protein XP_454453.1 983669 D 28985 CDS KLLA0_E11199g 2893773 complement(985522..986178) E 1 NC_006041.1 similar to uniprot|P38428 Saccharomyces cerevisiae YMR264W CUE1 Endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; uncharacterized protein 986178 2893773 KLLA0_E11199g Kluyveromyces lactis uncharacterized protein XP_454454.1 985522 R 28985 CDS KLLA0_E11221g 2893898 complement(986623..987123) E 1 NC_006041.1 similar to uniprot|P38429 Saccharomyces cerevisiae YMR263W SAP30 Subunit of a histone deacetylase complex along with Rpd3p and Sin3p that is involved in silencing at telomeres rDNA and silent mating-type loci; uncharacterized protein 987123 2893898 KLLA0_E11221g Kluyveromyces lactis uncharacterized protein XP_454455.1 986623 R 28985 CDS KLLA0_E11243g 2893831 complement(987351..988325) E 1 NC_006041.1 similar to uniprot|P38430 Saccharomyces cerevisiae YMR262W Hypothetical ORF; uncharacterized protein 988325 2893831 KLLA0_E11243g Kluyveromyces lactis uncharacterized protein XP_454456.1 987351 R 28985 CDS KLLA0_E11265g 2893704 988846..992292 E 1 NC_006041.1 similar to uniprot|P38426 Saccharomyces cerevisiae YMR261C TPS3 115 kD regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex; trehalose 6-phosphate synthase/phosphatase complex subunit 992292 2893704 KLLA0_E11265g Kluyveromyces lactis trehalose 6-phosphate synthase/phosphatase complex subunit XP_454457.1 988846 D 28985 CDS KLLA0_E11287g 2894696 992638..993105 E 1 NC_006041.1 highly similar to uniprot|P38912 Saccharomyces cerevisiae YMR260C TIF11 Translation initiation factor eIF1A; uncharacterized protein 993105 2894696 KLLA0_E11287g Kluyveromyces lactis uncharacterized protein XP_454458.1 992638 D 28985 CDS KLLA0_E11309g 9487418 complement(993416..994498) E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 994498 9487418 KLLA0_E11309g Kluyveromyces lactis uncharacterized protein XP_002999402.1 993416 R 28985 CDS KLLA0_E11331g 2894232 complement(994770..996308) E 1 NC_006041.1 similar to uniprot|P38262 Saccharomyces cerevisiae YBR103W SIF2 Sir4p-Interacting Factor 535 amino acid protein containing 4 WD-40 repeats and a nuclear localization signal; uncharacterized protein 996308 2894232 KLLA0_E11331g Kluyveromyces lactis uncharacterized protein XP_454460.1 994770 R 28985 CDS KLLA0_E11353g 2894545 996736..998898 E 1 NC_006041.1 similar to uniprot|P38261 Saccharomyces cerevisiae YBR102C EXO84 Essential protein with dual roles in spliceosome assembly and exocytosis the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis; exocyst subunit EXO84 998898 2894545 KLLA0_E11353g Kluyveromyces lactis exocyst subunit EXO84 XP_454461.1 996736 D 28985 CDS KLLA0_E11375g 2893735 999242..1000111 E 1 NC_006041.1 similar to uniprot|P38260 Saccharomyces cerevisiae YBR101C FES1 Hsp70 (Ssa1p) nucleotide exchange factor cytosolic homolog of Sls1p which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; Hsp70 nucleotide exchange factor FES1 1000111 2893735 KLLA0_E11375g Kluyveromyces lactis Hsp70 nucleotide exchange factor FES1 XP_454462.1 999242 D 28985 CDS KLLA0_E11397g 2894598 complement(1000253..1002325) E 1 NC_006041.1 weakly similar to uniprot|P38257 Saccharomyces cerevisiae YBR098W MMS4 Protein involved in recombination and DNA repair; subunit of a structure-specific Mms4-Mus81 endonuclease that cleaves branched DNA; uncharacterized protein 1002325 2894598 KLLA0_E11397g Kluyveromyces lactis uncharacterized protein XP_454463.1 1000253 R 28985 CDS KLLA0_E11419g 2894599 complement(1002637..1005693) E 1 NC_006041.1 similar to uniprot|P32855 Saccharomyces cerevisiae YPR055W SEC8 Essential 121kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis; exocyst subunit SEC8 1005693 2894599 KLLA0_E11419g Kluyveromyces lactis exocyst subunit SEC8 XP_454464.1 1002637 R 28985 CDS KLLA0_E11441g 2894572 complement(1006025..1006891) E 1 NC_006041.1 weakly similar to uniprot|P18888 Saccharomyces cerevisiae YHL025W SNF6 Involved in global regulation of transcription subunit of the chromatin remodeling Snf/Swi complex; uncharacterized protein 1006891 2894572 KLLA0_E11441g Kluyveromyces lactis uncharacterized protein XP_454465.1 1006025 R 28985 CDS KLLA0_E11485g 2894592 1008460..1010949 E 1 NC_006041.1 similar to uniprot|P18962 Saccharomyces cerevisiae YHR028C; dipeptidyl aminopeptidase 1010949 2894592 KLLA0_E11485g Kluyveromyces lactis dipeptidyl aminopeptidase XP_454468.1 1008460 D 28985 CDS KLLA0_E11507g 2894593 1011380..1014337 E 1 NC_006041.1 similar to uniprot|P38764 Saccharomyces cerevisiae YHR027C RPN1 Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome may participate in the recognition of several ligands of the proteasome contains a leucine-rich repeat (LRR) domain a site for protein? protein interactions; proteasome regulatory particle base subunit RPN1 1014337 2894593 KLLA0_E11507g Kluyveromyces lactis proteasome regulatory particle base subunit RPN1 XP_454469.1 1011380 D 28985 CDS KLLA0_E11529g 2894597 complement(1014620..1015363) E 1 NC_006041.1 similar to uniprot|P23968 Saccharomyces cerevisiae YHR026W PPA1 Subunit c'' of the vacuolar ATPase which functions in acidification of the vacuole; H(+)-transporting V0 sector ATPase subunit c'' 1015363 2894597 KLLA0_E11529g Kluyveromyces lactis H(+)-transporting V0 sector ATPase subunit c'' XP_454470.1 1014620 R 28985 CDS KLLA0_E11551g 2894557 complement(1015657..1016739) E 1 NC_006041.1 highly similar to uniprot|P17423 Saccharomyces cerevisiae YHR025W THR1 homoserine kinase; homoserine kinase 1016739 2894557 KLLA0_E11551g Kluyveromyces lactis homoserine kinase XP_454471.1 1015657 R 28985 CDS KLLA0_E11573g 2894121 1017355..1018833 E 1 NC_006041.1 similar to uniprot|P11914 Saccharomyces cerevisiae YHR024C MAS2 Larger subunit of the mitochondrial processing protease essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins; mitochondrial-processing protease subunit alpha 1018833 2894121 KLLA0_E11573g Kluyveromyces lactis mitochondrial-processing protease subunit alpha XP_454472.1 1017355 D 28985 CDS KLLA0_E11595g 2894551 complement(1018972..1024518) E 1 NC_006041.1 similar to uniprot|P08964 Saccharomyces cerevisiae YHR023W MYO1 Type II myosin heavy chain required for wild-type cytokinesis and cell separation localizes to the actomyosin ring binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively; myosin 1 1024518 2894551 KLLA0_E11595g Kluyveromyces lactis myosin 1 XP_454473.1 1018972 R 28985 CDS KLLA0_E11617g 2894552 1025228..1027183 E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 1027183 2894552 KLLA0_E11617g Kluyveromyces lactis uncharacterized protein XP_454474.1 1025228 D 28985 CDS KLLA0_E11639g 2894582 1028781..1029998 E 1 NC_006041.1 similar to uniprot|Q75C51 Ashbya gossypii ACR066C ACR066Cp and weakly similar to YOR101W uniprot|P01119 Saccharomyces cerevisiae YOR101W RAS1 GTPase involved in G-protein signaling in the adenylate cyclase activating pathway plays a role in cell proliferation localized to the plasma membrane homolog of mammalian RAS proto- oncogenes; uncharacterized protein 1029998 2894582 KLLA0_E11639g Kluyveromyces lactis uncharacterized protein XP_454476.1 1028781 D 28985 CDS KLLA0_E11661g 2894566 join(1030674..1030676,1031278..1031523) E 1 NC_006041.1 highly similar to uniprot|P38711 Saccharomyces cerevisiae YHR021c RPS27B ribosomal protein and to uniprot|P35997 Saccharomyces cerevisiae YKL156w RPS27A, Protein component of the small (40S) ribosomal subunit; 40S ribosomal protein eS27 1031523 2894566 KLLA0_E11661g Kluyveromyces lactis 40S ribosomal protein eS27 XP_454477.1 1030674 D 28985 CDS KLLA0_E11683g 2894567 complement(1031875..1034064) E 1 NC_006041.1 similar to uniprot|P36056 Saccharomyces cerevisiae YKL155C RSM22 Mitochondrial ribosomal protein of the small subunit; tRNA methyltransferase RSM22 1034064 2894567 KLLA0_E11683g Kluyveromyces lactis tRNA methyltransferase RSM22 XP_454479.1 1031875 R 28985 CDS KLLA0_E11705g 2894583 1034361..1035134 E 1 NC_006041.1 similar to uniprot|P36057 Saccharomyces cerevisiae YKL154W SRP102 Signal recognition particle (SRP) receptor beta subunit involved in SRP-dependent protein targeting anchors Srp101p to the ER membrane.; Signal recognition particle receptor subunit beta 1035134 2894583 KLLA0_E11705g Kluyveromyces lactis Signal recognition particle receptor subunit beta XP_454480.1 1034361 D 28985 CDS KLLA0_E11727g 9487327 complement(1035282..1035527) E 1 NC_006041.1 similar to uniprot|Q2V2P5 Saccharomyces cerevisiae YIL102C-A; uncharacterized protein 1035527 9487327 KLLA0_E11727g Kluyveromyces lactis uncharacterized protein XP_002999403.1 1035282 R 28985 CDS KLLA0_E11771g 2894549 1036220..1041166 E 1 NC_006041.1 similar to uniprot|P47054 Saccharomyces cerevisiae YJL039C NUP192 Essential structural subunit of the nuclear pore complex (NPC) localizes to the nuclear periphery of nuclear pores homologous to human p205; uncharacterized protein 1041166 2894549 KLLA0_E11771g Kluyveromyces lactis uncharacterized protein XP_454481.1 1036220 D 28985 CDS KLLA0_E11793g 2894550 complement(1041272..1043614) E 1 NC_006041.1 weakly similar to uniprot|P14907 Saccharomyces cerevisiae YJL041W NSP1 Essential component of the nuclear pore complex which mediates nuclear import and export; FG-nucleoporin NSP1 1043614 2894550 KLLA0_E11793g Kluyveromyces lactis FG-nucleoporin NSP1 XP_454482.1 1041272 R 28985 CDS KLLA0_E11815g 2894558 complement(1044591..1048385) E 1 NC_006041.1 similar to uniprot|P43638 Saccharomyces cerevisiae YJL042W MHP1 Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; uncharacterized protein 1048385 2894558 KLLA0_E11815g Kluyveromyces lactis uncharacterized protein XP_454484.1 1044591 R 28985 CDS KLLA0_E11837g 2893966 1049076..1049996 E 1 NC_006041.1 some similarities with uniprot|P32806 Saccharomyces cerevisiae YJL044C GYP6 GTPase-activating protein (GAP) for the yeast Rab family member Ypt6p involved in vesicle mediated protein transport; GTPase-activating protein GYP6 1049996 2893966 KLLA0_E11837g Kluyveromyces lactis GTPase-activating protein GYP6 XP_454485.1 1049076 D 28985 CDS KLLA0_E11859g 2894454 complement(1050114..1050857) E 1 NC_006041.1 highly similar to uniprot|P00950 Saccharomyces cerevisiae YKL152C GPM1 Tetrameric phosphoglycerate mutase of the glycolytic pathway converts 3-phosphoglycerate to 2-phosphoglycerate; phosphoglycerate mutase GPM1 1050857 2894454 KLLA0_E11859g Kluyveromyces lactis phosphoglycerate mutase GPM1 XP_454486.1 1050114 R 28985 CDS KLLA0_E11881g 2894455 1052911..1053744 E 1 NC_006041.1 similar to uniprot|P25613 Saccharomyces cerevisiae YCR010C ADY2 Accumulation of DYads member of the TC 9.B.33 YaaH family of putative transporters Protein involved in Accumulation of DYads or uniprot|P32907 Saccharomyces cerevisiae YNR002c; uncharacterized protein 1053744 2894455 KLLA0_E11881g Kluyveromyces lactis uncharacterized protein XP_454487.1 1052911 D 28985 CDS KLLA0_E11903g 2894546 1054430..1055230 E 1 NC_006041.1 highly similar to uniprot|P25343 Saccharomyces cerevisiae YCR009C RVS161 BAR adaptor protein subunit of a complex (Rvs161p Rvs167p) that regulates actin endocytosis and viability following starvation or osmotic stress; amphiphysin-like protein RVS161 1055230 2894546 KLLA0_E11903g Kluyveromyces lactis amphiphysin-like protein RVS161 XP_454488.1 1054430 D 28985 CDS KLLA0_E11925g 2893972 1055838..1059566 E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 1059566 2893972 KLLA0_E11925g Kluyveromyces lactis uncharacterized protein XP_454489.1 1055838 D 28985 CDS KLLA0_E11947g 2894543 complement(1060048..1061892) E 1 NC_006041.1 similar to uniprot|P25333 Saccharomyces cerevisiae YCR008W; serine/threonine protein kinase SAT4 1061892 2894543 KLLA0_E11947g Kluyveromyces lactis serine/threonine protein kinase SAT4 XP_454490.1 1060048 R 28985 CDS KLLA0_E12013g 2894564 complement(1063096..1065534) E 1 NC_006041.1 similar to uniprot|Q12102 Saccharomyces cerevisiae YLR115W; cleavage polyadenylation factor subunit CFT2 1065534 2894564 KLLA0_E12013g Kluyveromyces lactis cleavage polyadenylation factor subunit CFT2 XP_454491.1 1063096 R 28985 CDS KLLA0_E12035g 9487296 1066171..1067778 E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 1067778 9487296 KLLA0_E12035g Kluyveromyces lactis uncharacterized protein XP_002999404.1 1066171 D 28985 CDS KLLA0_E12057g 2893971 1068487..1074933 E 1 NC_006041.1 similar to uniprot|P43583 Saccharomyces cerevisiae YFL007W BLM3 Protein involved in assembly of proteasomal core particles in the nucleus required for normal resistance to bleomycin may be involved in protection against oxidative damage; uncharacterized protein 1074933 2893971 KLLA0_E12057g Kluyveromyces lactis uncharacterized protein XP_454493.1 1068487 D 28985 CDS KLLA0_E12079g 2894586 1075299..1075943 E 1 NC_006041.1 highly similar to uniprot|P07560 Saccharomyces cerevisiae YFL005W SEC4 Secretory vesicle-associated Rab GTPase essential for exocytosis associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane; Rab family GTPase SEC4 1075943 2894586 KLLA0_E12079g Kluyveromyces lactis Rab family GTPase SEC4 XP_454494.1 1075299 D 28985 CDS KLLA0_E12101g 2894662 1076424..1078949 E 1 NC_006041.1 similar to uniprot|P43585 Saccharomyces cerevisiae YFL004W VTC2 and similar to uniprot|Q02725 Saccharomyces cerevisiae YPL019C VTC3 Vacuolar membrane proteins; vacuolar transporter chaperone 1078949 2894662 KLLA0_E12101g Kluyveromyces lactis vacuolar transporter chaperone XP_454495.1 1076424 D 28985 CDS KLLA0_E12123g 2894539 1079451..1079996 E 1 NC_006041.1 similar to uniprot|P33421 Saccharomyces cerevisiae YKL141W SDH3 Cytochrome b subunit of succinate dehydrogenase (Sdh1p Sdh2p Sdh3p Sdh4p) which couples the oxidation of succinate to the transfer of electrons to ubiquinone and some similarites with YMR118C uniprot|Q04487 Saccharomyces cerevisiae YMR118C Hypothetical ORF, member of GLR.231; succinate dehydrogenase cytochrome b subunit SDH3 1079996 2894539 KLLA0_E12123g Kluyveromyces lactis succinate dehydrogenase cytochrome b subunit SDH3 XP_454496.1 1079451 D 28985 CDS KLLA0_E12145g 2894540 1080245..1081612 E 1 NC_006041.1 similar to uniprot|Q03957 Saccharomyces cerevisiae YKL139W CTK1 Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) which phosphorylates the C- terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing; cyclin-dependent serine/threonine protein kinase CTK1 1081612 2894540 KLLA0_E12145g Kluyveromyces lactis cyclin-dependent serine/threonine protein kinase CTK1 XP_454497.1 1080245 D 28985 CDS KLLA0_E12167g 9487320 complement(1081741..1081935) E 1 NC_006041.1 similar to uniprot|P69852 Saccharomyces cerevisiae YKL138C-A; uncharacterized protein 1081935 9487320 KLLA0_E12167g Kluyveromyces lactis uncharacterized protein XP_002999405.1 1081741 R 28985 CDS KLLA0_E12189g 2894210 1082163..1082732 E 1 NC_006041.1 similar to uniprot|Q04477 Saccharomyces cerevisiae YMR117C SPC24 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering; uncharacterized protein 1082732 2894210 KLLA0_E12189g Kluyveromyces lactis uncharacterized protein XP_454498.1 1082163 D 28985 CDS KLLA0_E12211g 2894542 complement(1082810..1083199) E 1 NC_006041.1 similar to uniprot|P14063 Saccharomyces cerevisiae YKL138C MRPL31 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein mL60 1083199 2894542 KLLA0_E12211g Kluyveromyces lactis mitochondrial 54S ribosomal protein mL60 XP_454499.1 1082810 R 28985 CDS KLLA0_E12233g 2894460 1083537..1083848 E 1 NC_006041.1 similar to uniprot|P36064 Saccharomyces cerevisiae YKL137W Hypothetical ORF; uncharacterized protein 1083848 2894460 KLLA0_E12233g Kluyveromyces lactis uncharacterized protein XP_454500.1 1083537 D 28985 CDS KLLA0_E12255g 2893985 complement(1084026..1086128) E 1 NC_006041.1 similar to uniprot|P36000 Saccharomyces cerevisiae YKL135C APL2 Beta-adaptin large subunit of the clathrin-associated protein (AP-1) complex; uncharacterized protein 1086128 2893985 KLLA0_E12255g Kluyveromyces lactis uncharacterized protein XP_454501.1 1084026 R 28985 CDS KLLA0_E12277g 2893986 join(1086778..1087329,1087730..1088158) E 1 NC_006041.1 highly similar to uniprot|P38011 Saccharomyces cerevisiae YMR116C ASC1 WD repeat protein (G-beta like protein) involved in translation regulation required for repression of Gcn4p activity in the absence of amino-acid starvation core component of the ribosome ortholog of mammalian RACK1; 40S ribosomal protein RACK1 1088158 2893986 KLLA0_E12277g Kluyveromyces lactis 40S ribosomal protein RACK1 XP_454502.1 1086778 D 28985 CDS KLLA0_E12321g 2894562 1088810..1089961 E 1 NC_006041.1 similar to uniprot|P38199 Saccharomyces cerevisiae YBL032W; uncharacterized protein 1089961 2894562 KLLA0_E12321g Kluyveromyces lactis uncharacterized protein XP_454503.1 1088810 D 28985 CDS KLLA0_E12343g 2894570 1090766..1091761 E 1 NC_006041.1 weakly similar to uniprot|P38200 Saccharomyces cerevisiae YBL031W SHE1 Cytoskeletal protein of unknown function overexpression causes growth arrest; uncharacterized protein 1091761 2894570 KLLA0_E12343g Kluyveromyces lactis uncharacterized protein XP_454504.1 1090766 D 28985 CDS KLLA0_E12365g 2894290 complement(1092303..1093220) E 1 NC_006041.1 highly similar to uniprot|P18239 Saccharomyces cerevisiae YBL030C PET9 Major ADP/ATP carrier of the mitochondrial inner membrane exchanges cytosolic ADP for mitochondrially synthesized ATP Pet9p and Sal1p have an overlapping function critical for viability; ADP/ATP carrier protein PET9 1093220 2894290 KLLA0_E12365g Kluyveromyces lactis ADP/ATP carrier protein PET9 XP_454505.1 1092303 R 28985 CDS KLLA0_E12387g 2894581 complement(1094372..1094647) E 1 NC_006041.1 similar to uniprot|Q3E756 Saccharomyces cerevisiae YBL029C-A; uncharacterized protein 1094647 2894581 KLLA0_E12387g Kluyveromyces lactis uncharacterized protein XP_454506.1 1094372 R 28985 CDS KLLA0_E12409g 2894588 1095828..1096724 E 1 NC_006041.1 some similarities with uniprot|P38201 Saccharomyces cerevisiae YBL029W Hypothetical ORF; uncharacterized protein 1096724 2894588 KLLA0_E12409g Kluyveromyces lactis uncharacterized protein XP_454508.1 1095828 D 28985 CDS KLLA0_E12431g 2894589 complement(1097009..1097359) E 1 NC_006041.1 similar to uniprot|P38202 Saccharomyces cerevisiae YBL028C; uncharacterized protein 1097359 2894589 KLLA0_E12431g Kluyveromyces lactis uncharacterized protein XP_454509.1 1097009 R 28985 CDS KLLA0_E12453g 2894568 join(1098094..1098095,1098542..1099109) E 1 NC_006041.1 highly similar to uniprot|P05735 Saccharomyces cerevisiae YBR084C-A RPL19A and to uniprot|P05735 Saccharomyces cerevisiae YBL027W RPL19B Proteins component of the large (60S) ribosomal subunit; 60S ribosomal protein eL19 1099109 2894568 KLLA0_E12453g Kluyveromyces lactis 60S ribosomal protein eL19 XP_454510.1 1098094 D 28985 CDS KLLA0_E12475g 2893957 complement(1100281..1103196) E 1 NC_006041.1 highly similar to uniprot|P09440 Saccharomyces cerevisiae YBR084W MIS1 Mitochondrial C1-tetrahydrofolate synthase involved in interconversion between different oxidation states of tetrahydrofolate (THF) provides activities of formyl-THF synthetase methenyl-THF cyclohydrolase and methylene-THF dehydrogenase; trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase MIS1 1103196 2893957 KLLA0_E12475g Kluyveromyces lactis trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase MIS1 XP_454511.1 1100281 R 28985 CDS KLLA0_E12497g 2894441 complement(1103583..1105457) E 1 NC_006041.1 weakly similar to uniprot|P18412 Saccharomyces cerevisiae YBR083W TEC1 transcription factor of the TEA/ATTS DNA-binding domain family regulator of Ty1 expression; uncharacterized protein 1105457 2894441 KLLA0_E12497g Kluyveromyces lactis uncharacterized protein XP_454512.1 1103583 R 28985 CDS KLLA0_E12519g 2894112 complement(1107848..1110868) E 1 NC_006041.1 similar to uniprot|Q12176 Saccharomyces cerevisiae YDR060W MAK21 Protein required for large (60S) ribosomal subunit biogenesis involved in nuclear export of pre-ribosomes required for maintenance of dsRNA virus homolog of human CAATT-binding protein; RNA-binding ribosome biosynthesis protein MAK21 1110868 2894112 KLLA0_E12519g Kluyveromyces lactis RNA-binding ribosome biosynthesis protein MAK21 XP_454513.1 1107848 R 28985 CDS KLLA0_E12541g 2894584 complement(1112440..1113630) E 1 NC_006041.1 some similarities with uniprot|Q12398 Saccharomyces cerevisiae YOR032C; uncharacterized protein 1113630 2894584 KLLA0_E12541g Kluyveromyces lactis uncharacterized protein XP_454514.1 1112440 R 28985 CDS KLLA0_E12563g 2893979 join(1117022..1117068,1117342..1117741) E 1 NC_006041.1 highly similar to uniprot|P15731 Saccharomyces cerevisiae YBR082C UBC4 Ubiquitin-conjugating enzyme that mediates degradation of short-lived and abnormal proteins interacts with E3-CaM in ubiquitinating calmodulin interacts with many SCF ubiquitin protein ligases component of the cellular stress response; uncharacterized protein 1117741 2893979 KLLA0_E12563g Kluyveromyces lactis uncharacterized protein XP_454516.1 1117022 D 28985 CDS KLLA0_E12585g 2894183 1118642..1122544 E 1 NC_006041.1 similar to uniprot|P35177 Saccharomyces cerevisiae YBR081C SPT7 Subunit of the SAGA transcriptional regulatory complex involved in proper assembly of the complex also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex; SAGA histone acetyltransferase complex subunit SPT7 1122544 2894183 KLLA0_E12585g Kluyveromyces lactis SAGA histone acetyltransferase complex subunit SPT7 XP_454517.1 1118642 D 28985 CDS KLLA0_E12607g 2894447 complement(1122747..1124120) E 1 NC_006041.1 some similarities with uniprot|Q04313 Saccharomyces cerevisiae YDR057W YOS9 Glycoprotein of the ER membrane involved in ER-to-Golgi transport of glycosylphosphatidylinositol (GPI)-anchored proteins; uncharacterized protein 1124120 2894447 KLLA0_E12607g Kluyveromyces lactis uncharacterized protein XP_454518.1 1122747 R 28985 CDS KLLA0_E12629g 2894591 1124393..1124965 E 1 NC_006041.1 weakly similar to uniprot|Q12025 Saccharomyces cerevisiae YDR056C Hypothetical ORF; uncharacterized protein 1124965 2894591 KLLA0_E12629g Kluyveromyces lactis uncharacterized protein XP_454519.1 1124393 D 28985 CDS KLLA0_E12651g 2894554 1125573..1126388 E 1 NC_006041.1 similar to uniprot|P38790 Saccharomyces cerevisiae YHR067W HTD2 Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis required for respiratory growth and for normal mitochondrial morphology; hydroxyacyl-thioester dehydratase HTD2 1126388 2894554 KLLA0_E12651g Kluyveromyces lactis hydroxyacyl-thioester dehydratase HTD2 XP_454520.1 1125573 D 28985 CDS KLLA0_E12673g 2894555 complement(1126397..1127197) E 1 NC_006041.1 weakly similar to uniprot|Q06667 Saccharomyces cerevisiae YDR315C IPK1 Inositol 1 3 4 5 6-pentakisphosphate 2-kinase nuclear protein required for synthesis of 1 2 3 4 5 6-hexakisphosphate (phytate) which is integral to cell function has 2 motifs conserved in other fungi ipk1 gle1 double mutant is inviable; inositol pentakisphosphate 2-kinase 1127197 2894555 KLLA0_E12673g Kluyveromyces lactis inositol pentakisphosphate 2-kinase XP_454521.1 1126397 R 28985 CDS KLLA0_E12695g 2894123 1127497..1128636 E 1 NC_006041.1 highly similar to uniprot|P38791 Saccharomyces cerevisiae YHR068W DYS1 Deoxyhypusine synthase catalyzes formation of deoxyhypusine the first step in hypusine biosynthesis triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels tetrameric; deoxyhypusine synthase 1128636 2894123 KLLA0_E12695g Kluyveromyces lactis deoxyhypusine synthase XP_454522.1 1127497 D 28985 CDS KLLA0_E12717g 2894569 1128947..1130287 E 1 NC_006041.1 similar to uniprot|Q06668 Saccharomyces cerevisiae YDR316W OMS1 Protein integral to the mitochondrial membrane; uncharacterized protein 1130287 2894569 KLLA0_E12717g Kluyveromyces lactis uncharacterized protein XP_454523.1 1128947 D 28985 CDS KLLA0_E12739g 2893959 complement(1130385..1131698) E 1 NC_006041.1 similar to uniprot|P38792 Saccharomyces cerevisiae YHR069C RRP4 Ribosomal RNA Processing 3->5 exoribonuclease Component of the exosome 3->5 exonuclease complex with Rrp41p Rrp42p Rrp43p and Dis3p (Rrp44p).; exosome non-catalytic core subunit RRP4 1131698 2893959 KLLA0_E12739g Kluyveromyces lactis exosome non-catalytic core subunit RRP4 XP_454524.1 1130385 R 28985 CDS KLLA0_E12761g 2894600 1131727..1133235 E 1 NC_006041.1 similar to uniprot|P38793 Saccharomyces cerevisiae YHR070W TRM5 tRNA(m(1)G37)methyltransferase methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting highly conserved across Archaea Bacteria and Eukarya; tRNA (guanine) methyltransferase 1133235 2894600 KLLA0_E12761g Kluyveromyces lactis tRNA (guanine) methyltransferase XP_454525.1 1131727 D 28985 CDS KLLA0_E12783g 2894601 1134308..1134970 E 1 NC_006041.1 some similarities with uniprot|P38794 Saccharomyces cerevisiae YHR071W PCL5 Cyclin interacts with Pho85p cyclin-dependent kinase (Cdk) induced by Gcn4p at level of transcription specifically required for Gcn4p degradation may be sensor of cellular protein biosynthetic capacity; uncharacterized protein 1134970 2894601 KLLA0_E12783g Kluyveromyces lactis uncharacterized protein XP_454526.1 1134308 D 28985 CDS KLLA0_E12805g 2894587 1135181..1135780 E 1 NC_006041.1 similar to uniprot|Q02804 Saccharomyces cerevisiae YPL051W GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor; Arf family GTPase ARL3 1135780 2894587 KLLA0_E12805g Kluyveromyces lactis Arf family GTPase ARL3 XP_454527.1 1135181 D 28985 CDS KLLA0_E12827g 2894595 1136272..1137957 E 1 NC_006041.1 similar to uniprot|P11491 Saccharomyces cerevisiae YDR481C PHO8 Repressible alkaline phosphatase a glycoprotein localized to the vacuole regulated by levels of inorganic phosphate and by a system consisting of Pho4p Pho9p Pho80p Pho81p and Pho85p dephosphorylates phosphotyrosyl peptides; alkaline phosphatase PHO8 1137957 2894595 KLLA0_E12827g Kluyveromyces lactis alkaline phosphatase PHO8 XP_454528.1 1136272 D 28985 CDS KLLA0_E12849g 2894563 complement(1138282..1139460) E 1 NC_006041.1 highly similar to uniprot|P39107 Saccharomyces cerevisiae YPL050C MNN9 Subunit of Golgi mannosyltransferase complex also containing Anp1p Mnn10p Mnn11p and Hoc1p that mediates elongation of the polysaccharide mannan backbone forms a separate complex with Van1p that is also involved in backbone elongation; mannosyltransferase complex subunit MNN9 1139460 2894563 KLLA0_E12849g Kluyveromyces lactis mannosyltransferase complex subunit MNN9 XP_454529.1 1138282 R 28985 CDS KLLA0_E12871g 2894559 1139990..1140373 E 1 NC_006041.1 weakly similar to uniprot|P53062 Saccharomyces cerevisiae YGL247W BRR6 Essential nuclear envelope integral membrane protein required for nuclear transport depletion alters nucleoporin distribution and nuclear envelope morphology suggesting a role in the spatial organization of nuclear pores; uncharacterized protein 1140373 2894559 KLLA0_E12871g Kluyveromyces lactis uncharacterized protein XP_454530.1 1139990 D 28985 CDS KLLA0_E12893g 2894560 complement(1140409..1141563) E 1 NC_006041.1 similar to uniprot|P53063 Saccharomyces cerevisiae YGL246C RAI1 Nuclear protein that binds to and stabilizes the exoribonuclease Rat1p required for pre-rRNA processing; decapping nuclease 1141563 2894560 KLLA0_E12893g Kluyveromyces lactis decapping nuclease XP_454531.1 1140409 R 28985 CDS KLLA0_E12915g 2894602 complement(1142167..1144131) E 1 NC_006041.1 similar to uniprot|P32901 Saccharomyces cerevisiae YKR093W PTR2 Functions in transport of small peptides into the cell Peptide transporter; uncharacterized protein 1144131 2894602 KLLA0_E12915g Kluyveromyces lactis uncharacterized protein XP_454532.1 1142167 R 28985 CDS KLLA0_E12937g 2894574 1145337..1145960 E 1 NC_006041.1 no similarity; uncharacterized protein 1145960 2894574 KLLA0_E12937g Kluyveromyces lactis uncharacterized protein XP_454533.1 1145337 D 28985 CDS KLLA0_E12959g 2894541 complement(1146299..1148038) E 1 NC_006041.1 similar to uniprot|P32837 Saccharomyces cerevisiae YDL210W UGA4 Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA) localized to the vacuolar membrane; uncharacterized protein 1148038 2894541 KLLA0_E12959g Kluyveromyces lactis uncharacterized protein XP_454534.1 1146299 R 28985 CDS KLLA0_E12981g 2894655 complement(1150659..1151585) E 1 NC_006041.1 similar to uniprot|P40459 Saccharomyces cerevisiae YIL145C PAN6 Pantothenate synthase also known as pantoate-beta-alanine ligase required for pantothenic acid biosynthesis deletion causes pantothenic acid auxotrophy homologous to E. coli panC; pantoate--beta-alanine ligase PAN6 1151585 2894655 KLLA0_E12981g Kluyveromyces lactis pantoate--beta-alanine ligase PAN6 XP_454535.1 1150659 R 28985 CDS KLLA0_E13003g 2894656 1151967..1153988 E 1 NC_006041.1 similar to uniprot|P40460 Saccharomyces cerevisiae YIL144W TID3 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p) conserved coiled-coil protein involved in chromosome segregation spindle checkpoint activity kinetochore assembly and clustering; kinetochore-associated Ndc80 complex subunit NDC80 1153988 2894656 KLLA0_E13003g Kluyveromyces lactis kinetochore-associated Ndc80 complex subunit NDC80 XP_454536.1 1151967 D 28985 CDS KLLA0_E13025g 2894113 complement(1154244..1156820) E 1 NC_006041.1 highly similar to uniprot|Q00578 Saccharomyces cerevisiae YIL143C SSL2; TFIIH/NER complex ATPase/helicase subunit SSL2 1156820 2894113 KLLA0_E13025g Kluyveromyces lactis TFIIH/NER complex ATPase/helicase subunit SSL2 XP_454537.1 1154244 R 28985 CDS KLLA0_E13047g 2894556 1157346..1158452 E 1 NC_006041.1 some similarities with uniprot|P32583 Saccharomyces cerevisiae YKR092C SRP40 Suppressor of mutant AC40 subunit of RNA polymerase I and III nucleolar protein that is immunologically and structurally related to rat Nopp140 a nonribosomal protein of the nucleolus and coiled bodies; uncharacterized protein 1158452 2894556 KLLA0_E13047g Kluyveromyces lactis uncharacterized protein XP_454538.1 1157346 D 28985 CDS KLLA0_E13069g 2893791 1159034..1159282 E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 1159282 2893791 KLLA0_E13069g Kluyveromyces lactis uncharacterized protein XP_454539.1 1159034 D 28985 CDS KLLA0_E13091g 2893789 complement(1159382..1160473) E 1 NC_006041.1 similar to uniprot|Q12405 Saccharomyces cerevisiae YOR084W Putative lipase of the peroxisomal matrix transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; triglyceride lipase 1160473 2893789 KLLA0_E13091g Kluyveromyces lactis triglyceride lipase XP_454540.1 1159382 R 28985 CDS KLLA0_E13113g 2893790 complement(1161001..1162113) E 1 NC_006041.1 weakly similar to uniprot|Q12416 Saccharomyces cerevisiae YOR083W WHI5 Protein that regulates the critical cell size required for passage through Start and commitment to cell division; may act upstream of SCB binding factor (SBF) and MCB binding factor (MBF); periodically expressed in G1; DNA-binding protein SRL3 1162113 2893790 KLLA0_E13113g Kluyveromyces lactis DNA-binding protein SRL3 XP_454541.1 1161001 R 28985 CDS KLLA0_E13135g 2893952 complement(1162722..1164599) E 1 NC_006041.1 weakly similar to uniprot|P36166 Saccharomyces cerevisiae YKR090W PXL1 LIM domain-containing protein that localizes to sites of polarized growth; uncharacterized protein 1164599 2893952 KLLA0_E13135g Kluyveromyces lactis uncharacterized protein XP_454542.1 1162722 R 28985 CDS KLLA0_E13157g 2893951 1165197..1166450 E 1 NC_006041.1 similar to uniprot|P48567 Saccharomyces cerevisiae YNL292W PUS4 catalyzes formation of Psi55 (modified uridine) in mitochondrial and cytoplasmic tRNAs Pseudouridine synthase; uncharacterized protein 1166450 2893951 KLLA0_E13157g Kluyveromyces lactis uncharacterized protein XP_454543.1 1165197 D 28985 CDS KLLA0_E13179g 2893949 complement(1166544..1168196) E 1 NC_006041.1 similar to uniprot|P41821 Saccharomyces cerevisiae YNL291C MID1 N-glycosylated integral plasma membrane protein; uncharacterized protein 1168196 2893949 KLLA0_E13179g Kluyveromyces lactis uncharacterized protein XP_454544.1 1166544 R 28985 CDS KLLA0_E13201g 2893950 1168489..1169478 E 1 NC_006041.1 highly similar to uniprot|P38629 YNL290W Saccharomyces cerevisiae RFC3 Subunit of heteropentameric Replication factor C (RF-C); replication factor C subunit 3 1169478 2893950 KLLA0_E13201g Kluyveromyces lactis replication factor C subunit 3 XP_454545.1 1168489 D 28985 CDS KLLA0_E13223g 2893948 1170139..1170987 E 1 NC_006041.1 similar to uniprot|P24867 Saccharomyces cerevisiae YNL289W PCL1 Pho85 cyclin of the Pcl1 2-like subfamily involved in entry into the mitotic cell cycle and regulation of morphogenesis localizes to sites of polarized cell growth; uncharacterized protein 1170987 2893948 KLLA0_E13223g Kluyveromyces lactis uncharacterized protein XP_454546.1 1170139 D 28985 CDS KLLA0_E13267g 2894508 1172956..1174221 E 1 NC_006041.1 similar to uniprot|P53829 Saccharomyces cerevisiae YNL288W CAF40 Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation elongation and degradation binds Cdc39p; CCR4-NOT core subunit CAF40 1174221 2894508 KLLA0_E13267g Kluyveromyces lactis CCR4-NOT core subunit CAF40 XP_454547.1 1172956 D 28985 CDS KLLA0_E13289g 2894507 1174507..1177341 E 1 NC_006041.1 similar to uniprot|P32074 Saccharomyces cerevisiae YNL287W SEC21 Gamma subunit of coatomer a heptameric protein complex that together with Arf1p forms the COPI coat involved in ER to Golgi transport of selective cargo; coatomer subunit gamma 1177341 2894507 KLLA0_E13289g Kluyveromyces lactis coatomer subunit gamma XP_454548.1 1174507 D 28985 CDS KLLA0_E13311g 2894505 1177801..1178322 E 1 NC_006041.1 similar to uniprot|Q12408 Saccharomyces cerevisiae YDL046W NPC2 Putative homolog of human NPC2/He1 which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes; sterol transporter 1178322 2894505 KLLA0_E13311g Kluyveromyces lactis sterol transporter XP_454549.1 1177801 D 28985 CDS KLLA0_E13333g 2894506 1178639..1179130 E 1 NC_006041.1 highly similar to uniprot|Q08230 Saccharomyces cerevisiae YOL071W EMI5 Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1 also required for sporulation; succinate dehydrogenase assembly factor SDH5 1179130 2894506 KLLA0_E13333g Kluyveromyces lactis succinate dehydrogenase assembly factor SDH5 XP_454550.1 1178639 D 28985 CDS KLLA0_E13355g 2894504 1179450..1179737 E 1 NC_006041.1 similar to uniprot|O75012 Saccharomyces cerevisiae YDL045W-A MRP10 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein mS37 1179737 2894504 KLLA0_E13355g Kluyveromyces lactis mitochondrial 37S ribosomal protein mS37 XP_454551.1 1179450 D 28985 CDS KLLA0_E13377g 2894661 complement(1179884..1180828) E 1 NC_006041.1 similar to uniprot|P38913 Saccharomyces cerevisiae YDL045C FAD1 Flavin adenine dinucleotide (FAD) synthetase performs the second step in synthesis of FAD from riboflavin; FMN adenylyltransferase 1180828 2894661 KLLA0_E13377g Kluyveromyces lactis FMN adenylyltransferase XP_454552.1 1179884 R 28985 CDS KLLA0_E13399g 2894659 complement(1181159..1182277) E 1 NC_006041.1 some similarities with uniprot|P10849 Saccharomyces cerevisiae YDL044C MTF2 Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription; uncharacterized protein 1182277 2894659 KLLA0_E13399g Kluyveromyces lactis uncharacterized protein XP_454553.1 1181159 R 28985 CDS KLLA0_E13421g 2894660 complement(1182524..1184344) E 1 NC_006041.1 similar to uniprot|Q08229 Saccharomyces cerevisiae YOL070C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm and bud neck potential Cdc28p substrate; uncharacterized protein 1184344 2894660 KLLA0_E13421g Kluyveromyces lactis uncharacterized protein XP_454554.1 1182524 R 28985 CDS KLLA0_E13443g 2893805 complement(1184806..1187526) E 1 NC_006041.1 similar to uniprot|Q12482 Saccharomyces cerevisiae YPR021C AGC1 Mitochondrial transporter acts both as a glutamate uniporter and as an aspartate-glutamate exchanger involved in nitrogen metabolism ornithine synthesis and the malate-aspartate NADH shuttle; citrin 1187526 2893805 KLLA0_E13443g Kluyveromyces lactis citrin XP_454555.1 1184806 R 28985 CDS KLLA0_E13465g 2893792 complement(1188323..1190527) E 1 NC_006041.1 weakly similar to uniprot|Q12139 Saccharomyces cerevisiae YPR022C Hypothetical ORF; uncharacterized protein 1190527 2893792 KLLA0_E13465g Kluyveromyces lactis uncharacterized protein XP_454557.1 1188323 R 28985 CDS KLLA0_E13487g 2893793 complement(1190615..1191307) E 1 NC_006041.1 some similarities with uniprot|Q12139 Saccharomyces cerevisiae YPR022C Hypothetical ORF; uncharacterized protein 1191307 2893793 KLLA0_E13487g Kluyveromyces lactis uncharacterized protein XP_454558.1 1190615 R 28985 CDS KLLA0_E13509g 2893794 complement(1191602..1192678) E 1 NC_006041.1 similar to uniprot|Q12432 Saccharomyces cerevisiae YPR023C EAF3 Esa1p-associated factor nonessential component of the NuA4 acetyltransferase complex homologous to Drosophila dosage compensation protein MSL3; uncharacterized protein 1192678 2893794 KLLA0_E13509g Kluyveromyces lactis uncharacterized protein XP_454559.1 1191602 R 28985 CDS KLLA0_E13531g 2893716 1193481..1194902 E 1 NC_006041.1 some similarities with uniprot|P39962 Saccharomyces cerevisiae YER123W YCK3 plasma membrane-bound casein kinase I homolog; casein kinase YCK3 1194902 2893716 KLLA0_E13531g Kluyveromyces lactis casein kinase YCK3 XP_454560.1 1193481 D 28985 CDS KLLA0_E13553g 2893717 complement(1195444..1197186) E 1 NC_006041.1 weakly similar to uniprot|P40077 Saccharomyces cerevisiae YER124C DSE1 Daughter cell-specific protein may participate in pathways regulating cell wall metabolism deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall; uncharacterized protein 1197186 2893717 KLLA0_E13553g Kluyveromyces lactis uncharacterized protein XP_454561.1 1195444 R 28985 CDS KLLA0_E13575g 2893718 1198133..1200592 E 1 NC_006041.1 highly similar to uniprot|P39940 Saccharomyces cerevisiae YER125W RSP5 Ubiquitin-protein ligase involved in ubiquitin-mediated protein degradation plays a role in heat shock element (HSE)-mediated gene expression and multivesicular body sorting contains a hect (homologous to E6-AP carboxyl terminus) domain; NEDD4 family E3 ubiquitin-protein ligase 1200592 2893718 KLLA0_E13575g Kluyveromyces lactis NEDD4 family E3 ubiquitin-protein ligase XP_454562.1 1198133 D 28985 CDS KLLA0_E13597g 2893719 complement(1201715..1204183) E 1 NC_006041.1 weakly similar to uniprot|P39016 Saccharomyces cerevisiae YGL178W MPT5 Protein that specifically binds to mRNAs encoding chromatin modifiers and spindle pole body components has roles in longevity in maintenance of cell wall integrity and in sensitivity to and recovery from pheromone arrest; uncharacterized protein 1204183 2893719 KLLA0_E13597g Kluyveromyces lactis uncharacterized protein XP_454563.1 1201715 R 28985 CDS KLLA0_E13619g 2893720 complement(1205834..1206619) E 1 NC_006041.1 highly similar to uniprot|P40078 Saccharomyces cerevisiae YER126C NSA2 Constituent of 66S pre-ribosomal particles involved in 60S ribosomal subunit biogenesis; rRNA-processing protein NSA2 1206619 2893720 KLLA0_E13619g Kluyveromyces lactis rRNA-processing protein NSA2 XP_454564.1 1205834 R 28985 CDS KLLA0_E13641g 2894464 1206847..1208034 E 1 NC_006041.1 similar to uniprot|P40079 Saccharomyces cerevisiae YER127W LCP5 Essential protein involved in maturation of 18S rRNA depletion leads to inhibited pre-rRNA processing and reduced polysome levels localizes primarily to the nucleolus; uncharacterized protein 1208034 2894464 KLLA0_E13641g Kluyveromyces lactis uncharacterized protein XP_454565.1 1206847 D 28985 CDS KLLA0_E13663g 2894465 1208328..1208945 E 1 NC_006041.1 similar to uniprot|P40080 Saccharomyces cerevisiae YER128W Hypothetical ORF; uncharacterized protein 1208945 2894465 KLLA0_E13663g Kluyveromyces lactis uncharacterized protein XP_454566.1 1208328 D 28985 CDS KLLA0_E13685g 2894466 1209218..1211224 E 1 NC_006041.1 highly similar to uniprot|P47077 Saccharomyces cerevisiae YJL010C Protein required for cell viability; RNA-binding RNA processing protein NOP9 1211224 2894466 KLLA0_E13685g Kluyveromyces lactis RNA-binding RNA processing protein NOP9 XP_454567.1 1209218 D 28985 CDS KLLA0_E13707g 2894467 complement(1211389..1212045) E 1 NC_006041.1 similar to uniprot|P35719 Saccharomyces cerevisiae YKL142W; uncharacterized protein 1212045 2894467 KLLA0_E13707g Kluyveromyces lactis uncharacterized protein XP_454568.1 1211389 R 28985 CDS KLLA0_E13729g 2894468 complement(1212409..1213860) E 1 NC_006041.1 similar to uniprot|P34078 Saccharomyces cerevisiae YKL143W LTV1 Protein required for growth at low temperature; uncharacterized protein 1213860 2894468 KLLA0_E13729g Kluyveromyces lactis uncharacterized protein XP_454569.1 1212409 R 28985 CDS KLLA0_E13751g 2893996 1214440..1215072 E 1 NC_006041.1 highly similar to uniprot|P35718 Saccharomyces cerevisiae YKL144C RPC25 RNA polymerase III subunit C25; DNA-directed RNA polymerase III subunit RPC25 1215072 2893996 KLLA0_E13751g Kluyveromyces lactis DNA-directed RNA polymerase III subunit RPC25 XP_454570.1 1214440 D 28985 CDS KLLA0_E13773g 2893997 complement(1215253..1216680) E 1 NC_006041.1 highly similar to uniprot|P33299 Saccharomyces cerevisiae YKL145W RPT1 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates required for optimal CDC20 transcription interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p; proteasome regulatory particle base subunit RPT1 1216680 2893997 KLLA0_E13773g Kluyveromyces lactis proteasome regulatory particle base subunit RPT1 XP_454571.1 1215253 R 28985 CDS KLLA0_E13795g 2893999 complement(1216938..1218659) E 1 NC_006041.1 similar to uniprot|P36062 Saccharomyces cerevisiae YKL146W AVT3 Vacuolar transporter exports large neutral amino acids from the vacuole member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; uncharacterized protein 1218659 2893999 KLLA0_E13795g Kluyveromyces lactis uncharacterized protein XP_454573.1 1216938 R 28985 CDS KLLA0_E13817g 2894000 1219430..1222099 E 1 NC_006041.1 highly similar to uniprot|Q02207 Saccharomyces cerevisiae YKR009C FOX2 Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities; bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2 1222099 2894000 KLLA0_E13817g Kluyveromyces lactis bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2 XP_454574.1 1219430 D 28985 CDS KLLA0_E13839g 2893945 complement(join(1222491..1222718,1222985..1222993)) E 1 NC_006041.1 similar to uniprot|P37299 Saccharomyces cerevisiae YHR001W-A QCR10 8.5 kDa subunit of the ubiqunol-cytochrome c oxidoreductase complex; ubiquinol--cytochrome-c reductase subunit 10 1222993 2893945 KLLA0_E13839g Kluyveromyces lactis ubiquinol--cytochrome-c reductase subunit 10 XP_454575.1 1222491 R 28985 CDS KLLA0_E13861g 2893946 complement(1223289..1224539) E 1 NC_006041.1 similar to uniprot|P27810 Saccharomyces cerevisiae YOR099W KTR1 Alpha-1 2-mannosyltransferase involved in O-and N-linked protein glycosylation member of the KRE2/MNT1 mannosyltransferase family; uncharacterized protein 1224539 2893946 KLLA0_E13861g Kluyveromyces lactis uncharacterized protein XP_454576.1 1223289 R 28985 CDS KLLA0_E13883g 2893947 complement(1225727..1230157) E 1 NC_006041.1 no similarity; uncharacterized protein 1230157 2893947 KLLA0_E13883g Kluyveromyces lactis uncharacterized protein XP_454577.1 1225727 R 28985 CDS KLLA0_E13905g 2893645 1231826..1233544 E 1 NC_006041.1 similar to uniprot|Q12031 Saccharomyces cerevisiae YPR006C ICL2 2-methylisocitrate lyase of the mitochondrial matrix functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate ICL2 transcription is repressed by glucose and induced by ethanol; methylisocitrate lyase ICL2 1233544 2893645 KLLA0_E13905g Kluyveromyces lactis methylisocitrate lyase ICL2 XP_454578.1 1231826 D 28985 CDS KLLA0_E13927g 2893646 1234293..1235291 E 1 NC_006041.1 no similarity; uncharacterized protein 1235291 2893646 KLLA0_E13927g Kluyveromyces lactis uncharacterized protein XP_454579.1 1234293 D 28985 CDS KLLA0_E13949g 2893647 1236690..1238051 E 1 NC_006041.1 no similarity; uncharacterized protein 1238051 2893647 KLLA0_E13949g Kluyveromyces lactis uncharacterized protein XP_454580.1 1236690 D 28985 CDS KLLA0_E13971g 2893648 complement(1238160..1239221) E 1 NC_006041.1 similar to uniprot|P43591 Saccharomyces cerevisiae YFR007W Hypothetical ORF; uncharacterized protein 1239221 2893648 KLLA0_E13971g Kluyveromyces lactis uncharacterized protein XP_454581.1 1238160 R 28985 CDS KLLA0_E13993g 2893649 complement(1239566..1241602) E 1 NC_006041.1 some similarities with uniprot|P07272 Saccharomyces cerevisiae YLR014C PPR1 Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain positively regulates transcription of genes involved in uracil biosynthesis activity may be modulated by interaction with Tup1p; uncharacterized protein 1241602 2893649 KLLA0_E13993g Kluyveromyces lactis uncharacterized protein XP_454582.1 1239566 R 28985 CDS KLLA0_E14015g 2894160 1242786..1243832 E 1 NC_006041.1 similar to uniprot|Q07589 Saccharomyces cerevisiae YDL144C Hypothetical ORF; uncharacterized protein 1243832 2894160 KLLA0_E14015g Kluyveromyces lactis uncharacterized protein XP_454583.1 1242786 D 28985 CDS KLLA0_E14037g 2894161 1244141..1245166 E 1 NC_006041.1 similar to uniprot|Q12480 Saccharomyces cerevisiae YPR004C Hypothetical ORF; uncharacterized protein 1245166 2894161 KLLA0_E14037g Kluyveromyces lactis uncharacterized protein XP_454584.1 1244141 D 28985 CDS KLLA0_E14059g 2894162 1245694..1247814 E 1 NC_006041.1 similar to uniprot|P53394 Saccharomyces cerevisiae YPR003C Hypothetical ORF; uncharacterized protein 1247814 2894162 KLLA0_E14059g Kluyveromyces lactis uncharacterized protein XP_454585.1 1245694 D 28985 CDS KLLA0_E14103g 2894164 complement(1248332..1249927) E 1 NC_006041.1 similar to uniprot|P43590 Saccharomyces cerevisiae YFR006W Hypothetical ORF; uncharacterized protein 1249927 2894164 KLLA0_E14103g Kluyveromyces lactis uncharacterized protein XP_454586.1 1248332 R 28985 CDS KLLA0_E14125g 2894175 1250334..1251767 E 1 NC_006041.1 similar to uniprot|P43589 Saccharomyces cerevisiae YFR005C SAD1 Conserved zinc-finger domain protein involved in pre-mRNA splicing required for assembly of U4 snRNA into the U4/U6 particle; mRNA splicing protein SAD1 1251767 2894175 KLLA0_E14125g Kluyveromyces lactis mRNA splicing protein SAD1 XP_454587.1 1250334 D 28985 CDS KLLA0_E14147g 2894176 complement(1251880..1252815) E 1 NC_006041.1 highly similar to uniprot|P43588 Saccharomyces cerevisiae YFR004W RPN11 Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid couples the deubiquitination and degradation of proteasome substrates; proteasome regulatory particle lid subunit RPN11 1252815 2894176 KLLA0_E14147g Kluyveromyces lactis proteasome regulatory particle lid subunit RPN11 XP_454588.1 1251880 R 28985 CDS KLLA0_E14169g 2894177 1253498..1253965 E 1 NC_006041.1 weakly similar to uniprot|P43587 Saccharomyces cerevisiae YFR003C YPI1 Inhibitor of the type I protein phosphatase Glc7p which is involved in regulation of a variety of metabolic processes overproduction causes decreased cellular content of glycogen; type 1 protein phosphatase-activating protein YPI1 1253965 2894177 KLLA0_E14169g Kluyveromyces lactis type 1 protein phosphatase-activating protein YPI1 XP_454589.1 1253498 D 28985 CDS KLLA0_E14191g 2894178 complement(1254213..1256795) E 1 NC_006041.1 similar to uniprot|P34077 Saccharomyces cerevisiae YFR002W NIC96 Component of the nuclear pore complex required for nuclear pore formation forms a subcomplex with Nsp1p Nup57p and Nup49p; linker nucleoporin NIC96 1256795 2894178 KLLA0_E14191g Kluyveromyces lactis linker nucleoporin NIC96 XP_454590.1 1254213 R 28985 CDS KLLA0_E14213g 2894179 complement(1257304..1258902) E 1 NC_006041.1 highly similar to uniprot|Q12428 Saccharomyces cerevisiae YPR002W PDH1 Mitochondrial protein that participates in respiration induced by diauxic shift homologous to E. coli PrpD may take part in the conversion of 2-methylcitrate to 2-methylisocitrate; uncharacterized protein 1258902 2894179 KLLA0_E14213g Kluyveromyces lactis uncharacterized protein XP_454591.1 1257304 R 28985 CDS KLLA0_E14235g 2893930 complement(1260247..1261668) E 1 NC_006041.1 highly similar to uniprot|P43635 Saccharomyces cerevisiae YPR001W CIT3 Citrate synthase catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate mitochondrial isozyme involved in the TCA cycle; citrate (Si)-synthase CIT3 1261668 2893930 KLLA0_E14235g Kluyveromyces lactis citrate (Si)-synthase CIT3 XP_454592.1 1260247 R 28985 CDS KLLA0_E14257g 2893931 complement(1262619..1263242) E 1 NC_006041.1 similar to uniprot|P43586 Saccharomyces cerevisiae YFR001W LOC1 Nuclear protein involved in asymmetric localization of ASH1 mRNA binds double-stranded RNA in vitro; uncharacterized protein 1263242 2893931 KLLA0_E14257g Kluyveromyces lactis uncharacterized protein XP_454593.1 1262619 R 28985 CDS KLLA0_E14301g 2893933 complement(1264866..1266038) E 1 NC_006041.1 similar to uniprot|Q12341 Saccharomyces cerevisiae YPL001W HAT1 Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A to acetylate free nuclear and cytoplasmic histone H4 involved in telomeric silencing and DNA double-strand break repair; histone acetyltransferase catalytic subunit HAT1 1266038 2893933 KLLA0_E14301g Kluyveromyces lactis histone acetyltransferase catalytic subunit HAT1 XP_454594.1 1264866 R 28985 CDS KLLA0_E14323g 2893934 1266372..1267070 E 1 NC_006041.1 highly similar to uniprot|Q12483 Saccharomyces cerevisiae YPL002C SNF8 Component of the ESCRT-II complex which is involved in ubiquitin-dependent sorting of proteins into the endosome appears to be functionally related to SNF7 involved in glucose derepression; ESCRT-II subunit protein SNF8 1267070 2893934 KLLA0_E14323g Kluyveromyces lactis ESCRT-II subunit protein SNF8 XP_454595.1 1266372 D 28985 CDS KLLA0_E14345g 2893935 complement(1267186..1268520) E 1 NC_006041.1 similar to uniprot|P31115 Saccharomyces cerevisiae YFL001W DEG1 Non-essential tRNA:pseudouridine synthase introduces pseudouridines at position 38 or 39 in tRNA important for maintenance of translation efficiency and normal cell growth localizes to both the nucleus and cytoplasm; uncharacterized protein 1268520 2893935 KLLA0_E14345g Kluyveromyces lactis uncharacterized protein XP_454596.1 1267186 R 28985 CDS KLLA0_E14367g 2893925 1268901..1270691 E 1 NC_006041.1 similar to uniprot|P25808 Saccharomyces cerevisiae YFL002C SPB4 involved in the maturation of 25S ribosomal RNA ATP-dependent RNA helicase; uncharacterized protein 1270691 2893925 KLLA0_E14367g Kluyveromyces lactis uncharacterized protein XP_454597.1 1268901 D 28985 CDS KLLA0_E14389g 2893926 complement(1270718..1272154) E 1 NC_006041.1 weakly similar to uniprot|Q12059 Saccharomyces cerevisiae YPL003W ULA1 Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation) which may play a role in protein degradation; uncharacterized protein 1272154 2893926 KLLA0_E14389g Kluyveromyces lactis uncharacterized protein XP_454598.1 1270718 R 28985 CDS KLLA0_E14411g 2893927 1272947..1273903 E 1 NC_006041.1 highly similar to uniprot|Q12230 Saccharomyces cerevisiae YPL004C LSP1 Long chain base-responsive inhibitor of protein kinases Phk1p and Phk2p acts along with Pil1p to down-regulate heat stress resistance via regulation of the Pkc1p and Ypk1p pathways phosphorylated by Phk1p and Phk2p; lipid-binding protein LSP1 1273903 2893927 KLLA0_E14411g Kluyveromyces lactis lipid-binding protein LSP1 XP_454599.1 1272947 D 28985 CDS KLLA0_E14433g 2893928 complement(1274502..1275650) E 1 NC_006041.1 similar to uniprot|Q12358 Saccharomyces cerevisiae YLL057C JLP1 to Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; uncharacterized protein 1275650 2893928 KLLA0_E14433g Kluyveromyces lactis uncharacterized protein XP_454600.1 1274502 R 28985 CDS KLLA0_E14477g 2893651 complement(1281791..1283941) E 1 NC_006041.1 weakly similar to uniprot|Q08905 Saccharomyces cerevisiae YOR381w FRE3 protein Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; uncharacterized protein 1283941 2893651 KLLA0_E14477g Kluyveromyces lactis uncharacterized protein XP_454603.1 1281791 R 28985 CDS KLLA0_E14499g 2893652 1286923..1288563 E 1 NC_006041.1 similar to uniprot|P40988 Saccharomyces cerevisiae YMR319C FET4 Low-affinity Fe(II) transporter of the plasma membrane; uncharacterized protein 1288563 2893652 KLLA0_E14499g Kluyveromyces lactis uncharacterized protein XP_454604.1 1286923 D 28985 CDS KLLA0_E14543g 2893653 complement(1290917..1294591) E 1 NC_006041.1 some similarities with uniprot|P38894 Saccharomyces cerevisiae YHR211W; uncharacterized protein 1294591 2893653 KLLA0_E14543g Kluyveromyces lactis uncharacterized protein XP_454605.1 1290917 R 28985 CDS KLLA0_E14587g 2893711 complement(1297636..1300884) E 1 NC_006041.1 similar to uniprot|Q01896 Saccharomyces cerevisiae YDR039C ENA2 P-type ATPase sodium pump involved in Na efflux to allow salt tolerance likely not involved in Li efflux; uncharacterized protein 1300884 2893711 KLLA0_E14587g Kluyveromyces lactis uncharacterized protein XP_454607.1 1297636 R 28985 CDS KLLA0_E14609g 2893712 1302073..1303992 E 1 NC_006041.1 similar to uniprot|P38731 Saccharomyces cerevisiae YHL040C ARN1 Transporter member of the ARN family of transporters that specifically recognize siderophore-iron chelates responsible for uptake of iron bound to ferrirubin ferrirhodin and related siderophores; uncharacterized protein 1303992 2893712 KLLA0_E14609g Kluyveromyces lactis uncharacterized protein XP_454608.1 1302073 D 28985 CDS KLLA0_E14631g 2893713 complement(1304707..1307244) E 1 NC_006041.1 highly similar to uniprot|P07337 Kluyveromyces marxianus Beta-glucosidase precursor; uncharacterized protein 1307244 2893713 KLLA0_E14631g Kluyveromyces lactis uncharacterized protein XP_454609.1 1304707 R 28985 CDS KLLA0_E14653g 2893714 1309427..1310860 E 1 NC_006041.1 weakly similar to uniprot|P32466 Saccharomyces cerevisiae YDR345C HXT3 Low affinity glucose transporter of the major facilitator superfamily; uncharacterized protein 1310860 2893714 KLLA0_E14653g Kluyveromyces lactis uncharacterized protein XP_454610.1 1309427 D 28985 CDS KLLA0_E14675g 2893715 1312581..1314302 E 1 NC_006041.1 similar to uniprot|P32837 Saccharomyces cerevisiae YDL210W UGA4 Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA) localized to the vacuolar membrane; uncharacterized protein 1314302 2893715 KLLA0_E14675g Kluyveromyces lactis uncharacterized protein XP_454611.1 1312581 D 28985 CDS KLLA0_E14697g 2893887 complement(1316238..1318958) E 1 NC_006041.1 similar to uniprot|P53119 Saccharomyces cerevisiae YGL141W; ubiquitin-ubiquitin ligase HUL5 1318958 2893887 KLLA0_E14697g Kluyveromyces lactis ubiquitin-ubiquitin ligase HUL5 XP_454612.1 1316238 R 28985 CDS KLLA0_E14719g 2893888 1319163..1320968 E 1 NC_006041.1 similar to uniprot|P30777 Saccharomyces cerevisiae YGL142C GPI10 Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis putative alpha 1 2 mannosyltransferase required for addition of the third mannose onto the GPI core structure human PIG-Bp is a functional homolog; uncharacterized protein 1320968 2893888 KLLA0_E14719g Kluyveromyces lactis uncharacterized protein XP_454613.1 1319163 D 28985 CDS KLLA0_E14741g 2893889 complement(1321041..1322180) E 1 NC_006041.1 similar to uniprot|P40990 Saccharomyces cerevisiae YDL107W MSS2 Peripherally bound inner membrane protein of the mitochondrial matrix required for export of C-terminal tail of Cox2p through the inner membrane; uncharacterized protein 1322180 2893889 KLLA0_E14741g Kluyveromyces lactis uncharacterized protein XP_454614.1 1321041 R 28985 CDS KLLA0_E14763g 2893890 1322461..1323663 E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 1323663 2893890 KLLA0_E14763g Kluyveromyces lactis uncharacterized protein XP_454615.1 1322461 D 28985 CDS KLLA0_E14785g 2893891 complement(1323743..1324675) E 1 NC_006041.1 highly similar to uniprot|P06242 Saccharomyces cerevisiae YDL108W KIN28 Serine/threonine protein kinase subunit of the transcription factor TFIIH involved in transcription initiation at RNA polymerase II promoters; TFIIH complex serine/threonine-protein kinase subunit KIN28 1324675 2893891 KLLA0_E14785g Kluyveromyces lactis TFIIH complex serine/threonine-protein kinase subunit KIN28 XP_454616.1 1323743 R 28985 CDS KLLA0_E14807g 2894283 1324910..1326100 E 1 NC_006041.1 similar to uniprot|P30775 Saccharomyces cerevisiae YGL143C MRF1 Mitochondrial polypeptide chain release factor involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation lack of MRF1 causes mitochondrial genome instability; uncharacterized protein 1326100 2894283 KLLA0_E14807g Kluyveromyces lactis uncharacterized protein XP_454617.1 1324910 D 28985 CDS KLLA0_E14829g 2894042 1326334..1328367 E 1 NC_006041.1 similar to uniprot|P53118 Saccharomyces cerevisiae YGL144C ROG1 Protein with putative serine active lipase domain and similar to uniprot|Q12451 Saccharomyces cerevisiae YDL109C OSH2 oxysterol-binding proteins; uncharacterized protein 1328367 2894042 KLLA0_E14829g Kluyveromyces lactis uncharacterized protein XP_454618.1 1326334 D 28985 CDS KLLA0_E14851g 2894043 complement(1328372..1330381) E 1 NC_006041.1 similar to uniprot|P33891 Saccharomyces cerevisiae YGL145W TIP20 transport protein that interacts with Sec20p required for protein transport from the endoplasmic reticulum to the golgi apparatus; uncharacterized protein 1330381 2894043 KLLA0_E14851g Kluyveromyces lactis uncharacterized protein XP_454619.1 1328372 R 28985 CDS KLLA0_E14895g 2894045 complement(1331095..1331928) E 1 NC_006041.1 some similarities with uniprot|P32447 Saccharomyces cerevisiae YJL115W ASF1 Nucleosome assembly factor involved in chromatin assembly after DNA replication anti- silencing protein that causes derepression of silent loci when overexpressed; nucleosome assembly factor ASF1 1331928 2894045 KLLA0_E14895g Kluyveromyces lactis nucleosome assembly factor ASF1 XP_454620.1 1331095 R 28985 CDS KLLA0_E14917g 2894046 complement(1332378..1333469) E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 1333469 2894046 KLLA0_E14917g Kluyveromyces lactis uncharacterized protein XP_454621.1 1332378 R 28985 CDS KLLA0_E14939g 2894047 1334635..1335831 E 1 NC_006041.1 some similarities with uniprot|P36135 Saccharomyces cerevisiae YKR042W UTH1 Youth involved in determining yeast longevity involved in cell growth; uncharacterized protein 1335831 2894047 KLLA0_E14939g Kluyveromyces lactis uncharacterized protein XP_454622.1 1334635 D 28985 CDS KLLA0_E14961g 2893865 complement(1336543..1337358) E 1 NC_006041.1 highly similar to uniprot|P36136 Saccharomyces cerevisiae YKR043C Hypothetical ORF; sedoheptulose-bisphosphatase 1337358 2893865 KLLA0_E14961g Kluyveromyces lactis sedoheptulose-bisphosphatase XP_454623.1 1336543 R 28985 CDS KLLA0_E14983g 2893866 complement(1337771..1338658) E 1 NC_006041.1 similar to uniprot|P46956 Saccharomyces cerevisiae YJL117W PHO86 Protein specifically required for packaging of the high-affinity phosphate transporter Pho84p into COPII coated vesicles for transport to the plasma membrane transcription and localization are regulated by phosphate levels; uncharacterized protein 1338658 2893866 KLLA0_E14983g Kluyveromyces lactis uncharacterized protein XP_454624.1 1337771 R 28985 CDS KLLA0_E15005g 2893868 complement(1339324..1341024) E 1 NC_006041.1 similar to uniprot|P27614 Saccharomyces cerevisiae YJL172W CPS1 Vacuolar carboxypeptidase yscS expression is induced under low-nitrogen conditions; uncharacterized protein 1341024 2893868 KLLA0_E15005g Kluyveromyces lactis uncharacterized protein XP_454626.1 1339324 R 28985 CDS KLLA0_E15027g 2893869 complement(1341521..1342381) E 1 NC_006041.1 weakly similar to uniprot|P36139 Saccharomyces cerevisiae YKR046C PET10 Protein of unknown function that co-purifies with lipid particles expression pattern suggests a role in respiratory growth computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange; uncharacterized protein 1342381 2893869 KLLA0_E15027g Kluyveromyces lactis uncharacterized protein XP_454627.1 1341521 R 28985 CDS KLLA0_E15049g 2894742 complement(1343243..1344496) E 1 NC_006041.1 similar to uniprot|P25293 Saccharomyces cerevisiae YKR048C NAP1 Protein that interacts with mitotic cyclin Clb2p required for the regulation of microtubule dynamics during mitosis controls bud morphogenesis involved in the transport of H2A and H2B histones to the nucleus; histone chaperone NAP1 1344496 2894742 KLLA0_E15049g Kluyveromyces lactis histone chaperone NAP1 XP_454628.1 1343243 R 28985 CDS KLLA0_E15071g 2894743 1345080..1345793 E 1 NC_006041.1 highly similar to uniprot|P46969 Saccharomyces cerevisiae YJL121C RPE1 D-ribulose-5-Phosphate 3-epimerase; ribulose-phosphate 3-epimerase RPE1 1345793 2894743 KLLA0_E15071g Kluyveromyces lactis ribulose-phosphate 3-epimerase RPE1 XP_454629.1 1345080 D 28985 CDS KLLA0_E15093g 2894744 complement(1345930..1346412) E 1 NC_006041.1 similar to uniprot|P47019 Saccharomyces cerevisiae YJL122W Hypothetical ORF; uncharacterized protein 1346412 2894744 KLLA0_E15093g Kluyveromyces lactis uncharacterized protein XP_454630.1 1345930 R 28985 CDS KLLA0_E15115g 2894745 1347073..1348281 E 1 NC_006041.1 weakly similar to uniprot|P47018 Saccharomyces cerevisiae YJL123C Hypothetical ORF; uncharacterized protein 1348281 2894745 KLLA0_E15115g Kluyveromyces lactis uncharacterized protein XP_454631.1 1347073 D 28985 CDS KLLA0_E15137g 2894746 complement(1348350..1348739) E 1 NC_006041.1 similar to uniprot|P36141 Saccharomyces cerevisiae YKR049C FMP46 The authentic non-tagged protein was localized to the mitochondria; uncharacterized protein 1348739 2894746 KLLA0_E15137g Kluyveromyces lactis uncharacterized protein XP_454632.1 1348350 R 28985 CDS KLLA0_E15159g 2894197 1349357..1349896 E 1 NC_006041.1 similar to uniprot|P47017 Saccharomyces cerevisiae YJL124C LSM1 Component of small nuclear ribonucleoprotein complexes involved in mRNA decapping and decay; uncharacterized protein 1349896 2894197 KLLA0_E15159g Kluyveromyces lactis uncharacterized protein XP_454633.1 1349357 D 28985 CDS KLLA0_E15181g 2894198 complement(1350236..1351633) E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 1351633 2894198 KLLA0_E15181g Kluyveromyces lactis uncharacterized protein XP_454634.1 1350236 R 28985 CDS KLLA0_E15203g 2894199 1353232..1354857 E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 1354857 2894199 KLLA0_E15203g Kluyveromyces lactis uncharacterized protein XP_454635.1 1353232 D 28985 CDS KLLA0_E15225g 2894200 1355166..1356389 E 1 NC_006041.1 highly similar to uniprot|P46959 Saccharomyces cerevisiae YJL125C GCD14 Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd10p required for the modification of the adenine at position 58 in tRNAs especially tRNAi-Met first identified as a negative regulator of GCN4 expression; tRNA 1-methyladenosine methyltransferase subunit GCD14 1356389 2894200 KLLA0_E15225g Kluyveromyces lactis tRNA 1-methyladenosine methyltransferase subunit GCD14 XP_454636.1 1355166 D 28985 CDS KLLA0_E15247g 2894201 complement(1356442..1357350) E 1 NC_006041.1 similar to uniprot|P47016 Saccharomyces cerevisiae YJL126W; uncharacterized protein 1357350 2894201 KLLA0_E15247g Kluyveromyces lactis uncharacterized protein XP_454637.1 1356442 R 28985 CDS KLLA0_E15269g 2893726 1357782..1359470 E 1 NC_006041.1 similar to uniprot|P35208 Saccharomyces cerevisiae YJL127C SPT10 Putative histone acetylase required for transcriptional regulation at core promoters functions at or near the TATA box; uncharacterized protein 1359470 2893726 KLLA0_E15269g Kluyveromyces lactis uncharacterized protein XP_454638.1 1357782 D 28985 CDS KLLA0_E15291g 2893727 complement(1359509..1361590) E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 1361590 2893727 KLLA0_E15291g Kluyveromyces lactis uncharacterized protein XP_454639.1 1359509 R 28985 CDS KLLA0_E15313g 2893728 1362851..1365025 E 1 NC_006041.1 similar to uniprot|P08018 Saccharomyces cerevisiae YJL128C PBS2 MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway activated under severe osmotic stress; mitogen-activated protein kinase kinase PBS2 1365025 2893728 KLLA0_E15313g Kluyveromyces lactis mitogen-activated protein kinase kinase PBS2 XP_454640.1 1362851 D 28985 CDS KLLA0_E15335g 2893729 1365717..1368926 E 1 NC_006041.1 uniprot|Q9Y7B9 Kluyveromyces lactis trk1 Potassium transporter; uncharacterized protein 1368926 2893729 KLLA0_E15335g Kluyveromyces lactis uncharacterized protein XP_454641.1 1365717 D 28985 CDS KLLA0_E15357g 2893759 1370741..1377427 E 1 NC_006041.1 highly similar to uniprot|P07259 Saccharomyces cerevisiae YJL130C URA2 Multifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase) that catalyzes the two first reactions of the pyrimidine pathway; carbamoyl-phophate synthetase, aspartate transcarbamylase, and glutamine amidotransferase; bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase 1377427 2893759 KLLA0_E15357g Kluyveromyces lactis bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase XP_454643.1 1370741 D 28985 CDS KLLA0_E15379g 2893760 1378099..1379142 E 1 NC_006041.1 weakly similar to uniprot|P47015 Saccharomyces cerevisiae YJL131C Hypothetical ORF; uncharacterized protein 1379142 2893760 KLLA0_E15379g Kluyveromyces lactis uncharacterized protein XP_454644.1 1378099 D 28985 CDS KLLA0_E15401g 2893761 complement(1379248..1381383) E 1 NC_006041.1 similar to uniprot|P47014 Saccharomyces cerevisiae YJL132W Hypothetical ORF; uncharacterized protein 1381383 2893761 KLLA0_E15401g Kluyveromyces lactis uncharacterized protein XP_454645.1 1379248 R 28985 CDS KLLA0_E15423g 2893762 1381552..1382835 E 1 NC_006041.1 similar to uniprot|P36142 Saccharomyces cerevisiae YKR051W Hypothetical ORF; uncharacterized protein 1382835 2893762 KLLA0_E15423g Kluyveromyces lactis uncharacterized protein XP_454646.1 1381552 D 28985 CDS KLLA0_E15445g 2894704 complement(1383230..1384210) E 1 NC_006041.1 similar to uniprot|P23500 YKR052C Saccharomyces cerevisiae YKR052C MRS4 Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs3p; functions under low-iron conditions; may transport other cations in addition to iron; uncharacterized protein 1384210 2894704 KLLA0_E15445g Kluyveromyces lactis uncharacterized protein XP_454647.1 1383230 R 28985 CDS KLLA0_E15467g 2894705 1385802..1386722 E 1 NC_006041.1 weakly similar to uniprot|P50091 Saccharomyces cerevisiae YGR239C PEX21 protein Part of a two-member peroxin family; uncharacterized protein 1386722 2894705 KLLA0_E15467g Kluyveromyces lactis uncharacterized protein XP_454648.1 1385802 D 28985 CDS KLLA0_E15489g 2894706 complement(1386926..1388254) E 1 NC_006041.1 weakly similar to uniprot|P38854 Saccharomyces cerevisiae YHR159W; uncharacterized protein 1388254 2894706 KLLA0_E15489g Kluyveromyces lactis uncharacterized protein XP_454649.1 1386926 R 28985 CDS KLLA0_E15511g 2894707 1388626..1391343 E 1 NC_006041.1 similar to uniprot|P50090 Saccharomyces cerevisiae YGR238C KEL2 Protein that functions in a complex with Kel1p to negatively regulate mitotic exit interacts with Tem1p and Lte1p localizes to regions of polarized growth potential Cdc28p substrate AND similar to YHR158C uniprot|P38853 Saccharomyces cerevisiae YHR158C KEL1 Protein required for proper cell fusion and cell morphology functions in a complex with Kel2p to negatively regulate mitotic exit interacts with Tem1p and Lte1p localizes to regions of polarized growth potential Cdc28p substrate; uncharacterized protein 1391343 2894707 KLLA0_E15511g Kluyveromyces lactis uncharacterized protein XP_454650.1 1388626 D 28985 CDS KLLA0_E15533g 2894022 complement(1391524..1391976) E 1 NC_006041.1 no similarity; uncharacterized protein 1391976 2894022 KLLA0_E15533g Kluyveromyces lactis uncharacterized protein XP_454651.1 1391524 R 28985 CDS KLLA0_E15555g 2894023 1393066..1395366 E 1 NC_006041.1 some similarities with uniprot|P50089 Saccharomyces cerevisiae YGR237C Hypothetical ORF; uncharacterized protein 1395366 2894023 KLLA0_E15555g Kluyveromyces lactis uncharacterized protein XP_454652.1 1393066 D 28985 CDS KLLA0_E15577g 2894024 1396270..1396581 E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 1396581 2894024 KLLA0_E15577g Kluyveromyces lactis uncharacterized protein XP_454653.1 1396270 D 28985 CDS KLLA0_E15599g 2894025 1397094..1397786 E 1 NC_006041.1 similar to uniprot|P50087 Saccharomyces cerevisiae YGR235C Hypothetical ORF; uncharacterized protein 1397786 2894025 KLLA0_E15599g Kluyveromyces lactis uncharacterized protein XP_454654.1 1397094 D 28985 CDS KLLA0_E15621g 2894026 complement(1397950..1400625) E 1 NC_006041.1 some similarities with uniprot|P38850 Saccharomyces cerevisiae YHR154W RTT107 Regulator of Ty1 Transposition Establishes Silent Chromatin involved in silencing; uncharacterized protein 1400625 2894026 KLLA0_E15621g Kluyveromyces lactis uncharacterized protein XP_454655.1 1397950 R 28985 CDS KLLA0_E15665g 2894470 1401239..1401784 E 1 NC_006041.1 no similarity; uncharacterized protein 1401784 2894470 KLLA0_E15665g Kluyveromyces lactis uncharacterized protein XP_454656.1 1401239 D 28985 CDS KLLA0_E15687g 2894471 1402940..1406386 E 1 NC_006041.1 similar to uniprot|P17442 Saccharomyces cerevisiae YGR233C PHO81 Cyclin-dependent kinase (CDK) inhibitor regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels required for derepression of PHO5 transcriptionally regulated by Pho4p and Pho2p; uncharacterized protein 1406386 2894471 KLLA0_E15687g Kluyveromyces lactis uncharacterized protein XP_454657.1 1402940 D 28985 CDS KLLA0_E15709g 2894472 complement(1406502..1407194) E 1 NC_006041.1 similar to uniprot|P50086 Saccharomyces cerevisiae YGR232W NAS6 Regulatory non-ATPase subunit of the 26S proteasome homolog of the human oncoprotein gankyrin which interacts with the retinoblastoma tumor suppressor (Rb) and cyclin-dependent kinase 4/6; uncharacterized protein 1407194 2894472 KLLA0_E15709g Kluyveromyces lactis uncharacterized protein XP_454658.1 1406502 R 28985 CDS KLLA0_E15731g 2894473 1407793..1408719 E 1 NC_006041.1 similar to uniprot|P50085 Saccharomyces cerevisiae YGR231C PHB2 Possible role in aging mitochondrial protein prohibitin homolog homolog of mammalian BAP37 and S. cerevisiae Phb1p; prohibitin subunit PHB2 1408719 2894473 KLLA0_E15731g Kluyveromyces lactis prohibitin subunit PHB2 XP_454659.1 1407793 D 28985 CDS KLLA0_E15753g 2894474 complement(1409122..1409379) E 1 NC_006041.1 some similarities with uniprot|P50084 Saccharomyces cerevisiae YGR230W BNS1 Protein with some similarity to Spo12p; uncharacterized protein 1409379 2894474 KLLA0_E15753g Kluyveromyces lactis uncharacterized protein XP_454660.1 1409122 R 28985 CDS KLLA0_E15775g 2894575 1409984..1411591 E 1 NC_006041.1 similar to uniprot|P32566 Saccharomyces cerevisiae YGR229C SMI1 Protein involved in (1 3)-beta-glucan synthesis possibly through regulation of cell wall glucan and chitin synthesis chromatin binding protein 57 kDa nuclear protein; uncharacterized protein 1411591 2894575 KLLA0_E15775g Kluyveromyces lactis uncharacterized protein XP_454661.1 1409984 D 28985 CDS KLLA0_E15797g 2894576 complement(1411759..1413360) E 1 NC_006041.1 similar to uniprot|P50076 Saccharomyces cerevisiae YGR227W DIE2 Dolichyl-phosphoglucose-dependent glucosyltransferase of the ER functions in the dolichol pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation has a role in regulation of ITR1 and INO1; dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-dolichol alpha-1,2- glucosyltransferase 1413360 2894576 KLLA0_E15797g Kluyveromyces lactis dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-dolichol alpha-1,2- glucosyltransferase XP_454662.1 1411759 R 28985 CDS KLLA0_E15819g 2894577 1413530..1415068 E 1 NC_006041.1 weakly similar to uniprot|P38849 Saccharomyces cerevisiae YHR151C hypothetical ORF; uncharacterized protein 1415068 2894577 KLLA0_E15819g Kluyveromyces lactis uncharacterized protein XP_454663.1 1413530 D 28985 CDS KLLA0_E15841g 2894578 complement(1415149..1416792) E 1 NC_006041.1 similar to uniprot|Q75AQ6 Ashbya gossypii ADL136C ADL136Cp and weakly similar to YHR150W uniprot|P38848 Saccharomyces cerevisiae YHR150W PEX28 Peroxisomal integral membrane protein involved in regulation of peroxisome size and number genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p Pex31p and Pex32p; uncharacterized protein 1416792 2894578 KLLA0_E15841g Kluyveromyces lactis uncharacterized protein XP_454664.1 1415149 R 28985 CDS KLLA0_E15863g 2894579 complement(1417190..1418956) E 1 NC_006041.1 weakly similar to uniprot|P50082 Saccharomyces cerevisiae YGR225W AMA1 Required for sporulation highly induced during sporulation activator of meiotic anaphase promoting complex Required for sporulation highly induced during sporulation; uncharacterized protein 1418956 2894579 KLLA0_E15863g Kluyveromyces lactis uncharacterized protein XP_454665.1 1417190 R 28985 CDS KLLA0_E15885g 2894192 1419922..1420941 E 1 NC_006041.1 weakly similar to uniprot|P50079 Saccharomyces cerevisiae YGR223C HSV2 Phosphatidylinositol 3 5-bisphosphate-binding protein predicted to fold as a seven-bladed beta-propeller displays punctate cytoplasmic localization; uncharacterized protein 1420941 2894192 KLLA0_E15885g Kluyveromyces lactis uncharacterized protein XP_454666.1 1419922 D 28985 CDS KLLA0_E15907g 2894193 complement(1421034..1421798) E 1 NC_006041.1 weakly similar to uniprot|P10834 Saccharomyces cerevisiae YGR222W PET54 Protein required for splicing of the COX1 intron AI5 beta also specifically required together with Pet122p and Pet494p for translation of the COX3 mRNA located in the mitochondrial inner membrane; uncharacterized protein 1421798 2894193 KLLA0_E15907g Kluyveromyces lactis uncharacterized protein XP_454667.1 1421034 R 28985 CDS KLLA0_E15973g 2894195 1423143..1425209 E 1 NC_006041.1 some similarities with uniprot|P32900 Saccharomyces cerevisiae YHR149C SKG6 Protein of unknown function found in the bud tip and bud neck potential Cdc28p substrate; uncharacterized protein 1425209 2894195 KLLA0_E15973g Kluyveromyces lactis uncharacterized protein XP_454668.1 1423143 D 28985 CDS KLLA0_E15995g 2894196 complement(1425473..1426024) E 1 NC_006041.1 highly similar to uniprot|P32899 Saccharomyces cerevisiae YHR148W IMP3 Component of the SSU processome which is required for pre-18S rRNA processing essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA; snoRNA-binding rRNA-processing protein IMP3 1426024 2894196 KLLA0_E15995g Kluyveromyces lactis snoRNA-binding rRNA-processing protein IMP3 XP_454669.1 1425473 R 28985 CDS KLLA0_E16017g 2894007 1426553..1427197 E 1 NC_006041.1 highly similar to uniprot|P32904 Saccharomyces cerevisiae YHR147C MRPL6 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein uL6m 1427197 2894007 KLLA0_E16017g Kluyveromyces lactis mitochondrial 54S ribosomal protein uL6m XP_454670.1 1426553 D 28985 CDS KLLA0_E16039g 2894008 1427540..1428361 E 1 NC_006041.1 similar to uniprot|P31334 Saccharomyces cerevisiae YGR220C MRPL9 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein uL3m 1428361 2894008 KLLA0_E16039g Kluyveromyces lactis mitochondrial 54S ribosomal protein uL3m XP_454671.1 1427540 D 28985 CDS KLLA0_E16061g 2894009 complement(1428731..1431991) E 1 NC_006041.1 highly similar to uniprot|P30822 Saccharomyces cerevisiae YGR218W CRM1 Major karyopherin involved in export of proteins RNAs and ribosomal subunits from the nucleus; exportin CRM1 1431991 2894009 KLLA0_E16061g Kluyveromyces lactis exportin CRM1 XP_454672.1 1428731 R 28985 CDS KLLA0_E16083g 2894010 complement(1432567..1438476) E 1 NC_006041.1 similar to uniprot|P50077 Saccharomyces cerevisiae YGR217W CCH1 Voltage-gated calcium channel involved in calcium influx in response to mating pheromones; uncharacterized protein 1438476 2894010 KLLA0_E16083g Kluyveromyces lactis uncharacterized protein XP_454673.1 1432567 R 28985 CDS KLLA0_E16105g 2894011 1438802..1440682 E 1 NC_006041.1 similar to uniprot|P53306 Saccharomyces cerevisiae YGR216C GPI1 Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol; phosphatidylinositol N-acetylglucosaminyltransferase 1440682 2894011 KLLA0_E16105g Kluyveromyces lactis phosphatidylinositol N-acetylglucosaminyltransferase XP_454674.1 1438802 D 28985 CDS KLLA0_E16127g 2894012 complement(1440897..1441223) E 1 NC_006041.1 highly similar to uniprot|P53305 Saccharomyces cerevisiae YGR215W RSM27 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein mS33 1441223 2894012 KLLA0_E16127g Kluyveromyces lactis mitochondrial 37S ribosomal protein mS33 XP_454675.1 1440897 R 28985 CDS KLLA0_E16149g 9487452 1441386..1441550 E 1 NC_006041.1 no similarity; uncharacterized protein 1441550 9487452 KLLA0_E16149g Kluyveromyces lactis uncharacterized protein XP_002999406.1 1441386 D 28985 CDS KLLA0_E16171g 2893732 complement(join(1441784..1442458,1443155..1443244)) E 1 NC_006041.1 highly similar to uniprot|P32905 Saccharomyces cerevisiae YGR214W RPS0A protein component of the small (40S) ribosomal subunit; 40S ribosomal protein uS2 1443244 2893732 KLLA0_E16171g Kluyveromyces lactis 40S ribosomal protein uS2 XP_454677.1 1441784 R 28985 CDS KLLA0_E16193g 2893734 1444770..1446443 E 1 NC_006041.1 similar to uniprot|Q12209 Saccharomyces cerevisiae YLR047C Hypothetical ORF; uncharacterized protein 1446443 2893734 KLLA0_E16193g Kluyveromyces lactis uncharacterized protein XP_454679.1 1444770 D 28985 CDS KLLA0_E16215g 2893829 complement(1446699..1448177) E 1 NC_006041.1 highly similar to uniprot|P53303 Saccharomyces cerevisiae YGR211W ZPR1 Essential protein with two zinc fingers present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p binds to translation elongation factor eEF-1 (Tef1p); zinc finger-containing protein ZPR1 1448177 2893829 KLLA0_E16215g Kluyveromyces lactis zinc finger-containing protein ZPR1 XP_454680.1 1446699 R 28985 CDS KLLA0_E16237g 2893830 1448683..1449912 E 1 NC_006041.1 highly similar to uniprot|P42942 Saccharomyces cerevisiae YGR210C Hypothetical ORF; uncharacterized protein 1449912 2893830 KLLA0_E16237g Kluyveromyces lactis uncharacterized protein XP_454681.1 1448683 D 28985 CDS KLLA0_E16259g 2893639 complement(1450546..1452348) E 1 NC_006041.1 uniprot|Q70DJ7 Kluyveromyces lactis jen1 Lactate permease; uncharacterized protein 1452348 2893639 KLLA0_E16259g Kluyveromyces lactis uncharacterized protein XP_454682.1 1450546 R 28985 CDS KLLA0_E16281g 2893640 1455271..1457088 E 1 NC_006041.1 similar to uniprot|P53388 Saccharomyces cerevisiae YPL265W DIP5 Dicarboxylic amino acid permease mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate also a transporter for Gln Asn Ser Ala and Gly; dicarboxylic amino acid permease 1457088 2893640 KLLA0_E16281g Kluyveromyces lactis dicarboxylic amino acid permease XP_454683.1 1455271 D 28985 CDS KLLA0_E16303g 2894295 complement(1457903..1459594) E 1 NC_006041.1 highly similar to uniprot|P06169 Saccharomyces cerevisiae YLR044C PDC1 Major of three pyruvate decarboxylase isozymes key enzyme in alcoholic fermentation decarboxylates pyruvate to acetaldehyde subject to glucose-ethanol- and autoregulation involved in amino acid catabolism; uncharacterized protein 1459594 2894295 KLLA0_E16303g Kluyveromyces lactis uncharacterized protein XP_454684.1 1457903 R 28985 CDS KLLA0_E16325g 2893641 complement(1460849..1463347) E 1 NC_006041.1 weakly similar to uniprot|P46675 Saccharomyces cerevisiae YLR045C STU2 Microtubule-associated protein (MAP) of the XMAP215/Dis1 family regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment interacts with spindle pole body component Spc72p; uncharacterized protein 1463347 2893641 KLLA0_E16325g Kluyveromyces lactis uncharacterized protein XP_454685.1 1460849 R 28985 CDS KLLA0_E16347g 2893642 1463917..1464231 E 1 NC_006041.1 highly similar to uniprot|P22217 Saccharomyces cerevisiae YLR043C TRX1 thioredoxin; thioredoxin TRX2 1464231 2893642 KLLA0_E16347g Kluyveromyces lactis thioredoxin TRX2 XP_454686.1 1463917 D 28985 CDS KLLA0_E16369g 2893643 complement(1464299..1465279) E 1 NC_006041.1 similar to uniprot|P42941 Saccharomyces cerevisiae YGR208W SER2 phosphoserine phosphatase; phosphoserine phosphatase 1465279 2893643 KLLA0_E16369g Kluyveromyces lactis phosphoserine phosphatase XP_454687.1 1464299 R 28985 CDS KLLA0_E16391g 2893695 1465648..1466427 E 1 NC_006041.1 similar to uniprot|P42940 YGR207C Saccharomyces cerevisiae YGR2 Hypothetical ORF; uncharacterized protein 1466427 2893695 KLLA0_E16391g Kluyveromyces lactis uncharacterized protein XP_454688.1 1465648 D 28985 CDS KLLA0_E16413g 2893696 complement(1466545..1466865) E 1 NC_006041.1 similar to uniprot|P42939 Saccharomyces cerevisiae YGR206W; uncharacterized protein 1466865 2893696 KLLA0_E16413g Kluyveromyces lactis uncharacterized protein XP_454689.1 1466545 R 28985 CDS KLLA0_E16435g 2893697 1467102..1467719 E 1 NC_006041.1 similar to uniprot|P47095 Saccharomyces cerevisiae YJR024C Hypothetical ORF; methylthioribulose 1-phosphate dehydratase MDE1 1467719 2893697 KLLA0_E16435g Kluyveromyces lactis methylthioribulose 1-phosphate dehydratase MDE1 XP_454690.1 1467102 D 28985 CDS KLLA0_E16457g 2893698 complement(1467758..1468048) E 1 NC_006041.1 similar to uniprot|P47093 Saccharomyces cerevisiae YJR022W LSM8 Component of small nuclear ribonucleoprotein complexes involved in RNA processing and splicing; U4/U6-U5 snRNP complex subunit LSM8 1468048 2893698 KLLA0_E16457g Kluyveromyces lactis U4/U6-U5 snRNP complex subunit LSM8 XP_454691.1 1467758 R 28985 CDS KLLA0_E16501g 2894213 complement(1469087..1469959) E 1 NC_006041.1 similar to uniprot|P42938 Saccharomyces cerevisiae YGR205W Protein that binds ATP crystal structure resembles that of E.coli pantothenate kinase; uncharacterized protein 1469959 2894213 KLLA0_E16501g Kluyveromyces lactis uncharacterized protein XP_454693.1 1469087 R 28985 CDS KLLA0_E16523g 2894214 1470356..1471360 E 1 NC_006041.1 similar to uniprot|P41903 Saccharomyces cerevisiae YJR019C TES1 Thioesterase peroxisomal acyl-CoA thioesterase; palmitoyl-CoA hydrolase 1471360 2894214 KLLA0_E16523g Kluyveromyces lactis palmitoyl-CoA hydrolase XP_454694.1 1470356 D 28985 CDS KLLA0_E16545g 2894215 complement(1471478..1474321) E 1 NC_006041.1 similar to uniprot|P07245 Saccharomyces cerevisiae YGR204W ADE3 Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase involved in single carbon metabolism and required for biosynthesis of purines thymidylate methionine and histidine; trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3 1474321 2894215 KLLA0_E16545g Kluyveromyces lactis trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3 XP_454695.1 1471478 R 28985 CDS KLLA0_E16567g 2894216 1475343..1475831 E 1 NC_006041.1 similar to uniprot|P22696 Saccharomyces cerevisiae YJR017C ESS1 Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline; peptidylprolyl isomerase ESS1 1475831 2894216 KLLA0_E16567g Kluyveromyces lactis peptidylprolyl isomerase ESS1 XP_454696.1 1475343 D 28985 CDS KLLA0_E16589g 2894217 complement(1475842..1476294) E 1 NC_006041.1 similar to uniprot|P42937 YGR203W Saccharomyces cerevisiae Probable protein tyrosine phosphatase of the CDC25-like phosphatase family; phosphatase YCH1 1476294 2894217 KLLA0_E16589g Kluyveromyces lactis phosphatase YCH1 XP_454697.1 1475842 R 28985 CDS KLLA0_E16611g 2893775 complement(1476592..1477821) E 1 NC_006041.1 similar to uniprot|P13259 Saccharomyces cerevisiae YGR202C PCT1 Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase; choline-phosphate cytidylyltransferase 1477821 2893775 KLLA0_E16611g Kluyveromyces lactis choline-phosphate cytidylyltransferase XP_454698.1 1476592 R 28985 CDS KLLA0_E16633g 2893776 complement(1478514..1479083) E 1 NC_006041.1 similar to uniprot|P38812 Saccharomyces cerevisiae YHR100C Hypothetical ORF; phosphatidylglycerophosphatase 1479083 2893776 KLLA0_E16633g Kluyveromyces lactis phosphatidylglycerophosphatase XP_454699.1 1478514 R 28985 CDS KLLA0_E16655g 2893777 1479322..1481292 E 1 NC_006041.1 similar to uniprot|Q05580 Saccharomyces cerevisiae YDR266C Hypothetical ORF; E3 ubiquitin-protein ligase HEL2 1481292 2893777 KLLA0_E16655g Kluyveromyces lactis E3 ubiquitin-protein ligase HEL2 XP_454700.1 1479322 D 28985 CDS KLLA0_E16677g 2893778 complement(1481372..1482289) E 1 NC_006041.1 similar to uniprot|Q05568 Saccharomyces cerevisiae YDR265W PEX10 RING finger peroxisomal membrane peroxin required for peroxisomal matrix protein import interacts with Pex12p links ubiquitin-conjugating Pex4p to protein import machinery mutations in human homolog cause a variety of peroxisomal disorders; ubiquitin-protein ligase peroxin 10 1482289 2893778 KLLA0_E16677g Kluyveromyces lactis ubiquitin-protein ligase peroxin 10 XP_454701.1 1481372 R 28985 CDS KLLA0_E16699g 2893779 1482505..1484490 E 1 NC_006041.1 similar to uniprot|P51534 Saccharomyces cerevisiae YOR035C SHE4 Protein containing a UCS (UNC-45/CRO1/SHE4) domain binds to myosin motor domains to regulate myosin function involved in endocytosis polarization of the actin cytoskeleton and asymmetric mRNA localization; uncharacterized protein 1484490 2893779 KLLA0_E16699g Kluyveromyces lactis uncharacterized protein XP_454702.1 1482505 D 28985 CDS KLLA0_E16721g 2893937 1484752..1487010 E 1 NC_006041.1 similar to uniprot|P39010 Saccharomyces cerevisiae YDR264C AKR1 Palmitoyl transferase involved in protein palmitoylation; uncharacterized protein 1487010 2893937 KLLA0_E16721g Kluyveromyces lactis uncharacterized protein XP_454703.1 1484752 D 28985 CDS KLLA0_E16743g 2893939 1487301..1489316 E 1 NC_006041.1 some similarities with uniprot|P39875 Saccharomyces cerevisiae YOR033C EXO1 5'-3' exonuclease and flap-endonuclease involved in recombination double-strand break repair and DNA mismatch repair member of the Rad2p nuclease family with conserved N and I nuclease domains; uncharacterized protein 1489316 2893939 KLLA0_E16743g Kluyveromyces lactis uncharacterized protein XP_454705.1 1487301 D 28985 CDS KLLA0_E16765g 2893940 1489864..1492689 E 1 NC_006041.1 some similarities with uniprot|Q12398 Saccharomyces cerevisiae YOR032C HMS1 C2H2 zinc-finger protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; uncharacterized protein 1492689 2893940 KLLA0_E16765g Kluyveromyces lactis uncharacterized protein XP_454706.1 1489864 D 28985 CDS KLLA0_E16787g 2893941 complement(1493491..1494291) E 1 NC_006041.1 similar to uniprot|Q12331 Saccharomyces cerevisiae YDR262W Hypothetical ORF; uncharacterized protein 1494291 2893941 KLLA0_E16787g Kluyveromyces lactis uncharacterized protein XP_454707.1 1493491 R 28985 CDS KLLA0_E16831g 2894166 complement(1494849..1496297) E 1 NC_006041.1 some similarities with uniprot|Q99234 Saccharomyces cerevisiae YOR030W DFG16 Probable multiple transmembrane protein involved in invasive growth upon nitrogen starvation; uncharacterized protein 1496297 2894166 KLLA0_E16831g Kluyveromyces lactis uncharacterized protein XP_454708.1 1494849 R 28985 CDS KLLA0_E16853g 2894167 1496719..1497051 E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 1497051 2894167 KLLA0_E16853g Kluyveromyces lactis uncharacterized protein XP_454709.1 1496719 D 28985 CDS KLLA0_E16875g 2894168 1498623..1500149 E 1 NC_006041.1 some similarities with uniprot|P40917 Saccharomyces cerevisiae YOR028C CIN5 Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus; uncharacterized protein 1500149 2894168 KLLA0_E16875g Kluyveromyces lactis uncharacterized protein XP_454710.1 1498623 D 28985 CDS KLLA0_E16897g 2894169 1500700..1503177 E 1 NC_006041.1 highly similar to uniprot|P33416 Saccharomyces cerevisiae YDR258C HSP78 Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock prevents the aggregation of misfolded matrix proteins component of the mitochondrial proteolysis system; chaperone ATPase HSP78 1503177 2894169 KLLA0_E16897g Kluyveromyces lactis chaperone ATPase HSP78 XP_454711.1 1500700 D 28985 CDS KLLA0_E16919g 2894170 complement(1503510..1507520) E 1 NC_006041.1 weakly similar to uniprot|Q06681 Saccharomyces cerevisiae YDR326C Hypothetical ORF; uncharacterized protein 1507520 2894170 KLLA0_E16919g Kluyveromyces lactis uncharacterized protein XP_454712.1 1503510 R 28985 CDS KLLA0_E16941g 2894498 complement(1507885..1508433) E 1 NC_006041.1 similar to uniprot|P52286 Saccharomyces cerevisiae YDR328C SKP1 evolutionarily conserved kinetochore protein that is part of multiple protein complexes; SCF ubiquitin ligase subunit SKP1 1508433 2894498 KLLA0_E16941g Kluyveromyces lactis SCF ubiquitin ligase subunit SKP1 XP_454713.1 1507885 R 28985 CDS KLLA0_E16963g 2894499 complement(1508739..1510190) E 1 NC_006041.1 similar to uniprot|P28795 Saccharomyces cerevisiae YDR329C PEX3 peroxisomal membrane protein; uncharacterized protein 1510190 2894499 KLLA0_E16963g Kluyveromyces lactis uncharacterized protein XP_454714.1 1508739 R 28985 CDS KLLA0_E16985g 2894500 complement(1510635..1511153) E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 1511153 2894500 KLLA0_E16985g Kluyveromyces lactis uncharacterized protein XP_454715.1 1510635 R 28985 CDS KLLA0_E17007g 2894501 1511603..1512136 E 1 NC_006041.1 similar to uniprot|P38801 Saccharomyces cerevisiae YHR081W LRP1 Substrate-specific nuclear cofactor for exosome activity in the processing of stable RNAs homolog of mammalian nuclear matrix protein C1D which is involved in regulation of DNA repair and recombination; uncharacterized protein 1512136 2894501 KLLA0_E17007g Kluyveromyces lactis uncharacterized protein XP_454716.1 1511603 D 28985 CDS KLLA0_E17029g 2894502 1512395..1513939 E 1 NC_006041.1 similar to uniprot|Q06682 Saccharomyces cerevisiae YDR330W UBX5 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; uncharacterized protein 1513939 2894502 KLLA0_E17029g Kluyveromyces lactis uncharacterized protein XP_454717.1 1512395 D 28985 CDS KLLA0_E17051g 2894186 1514295..1515521 E 1 NC_006041.1 similar to uniprot|P49018 Saccharomyces cerevisiae YDR331W GPI8 ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; GPI-anchor transamidase 1515521 2894186 KLLA0_E17051g Kluyveromyces lactis GPI-anchor transamidase XP_454718.1 1514295 D 28985 CDS KLLA0_E17073g 2893767 complement(1515721..1518279) E 1 NC_006041.1 similar to uniprot|Q759H7 Ashbya gossypii ADR300C ADR300Cp and weakly similar to YHR082C uniprot|P38691 Saccharomyces cerevisiae YHR082C KSP1 Nonessential putative serine/threonine protein kinase of unknown cellular role overproduction causes allele-specific suppression of the prp20-10 mutation; uncharacterized protein 1518279 2893767 KLLA0_E17073g Kluyveromyces lactis uncharacterized protein XP_454719.1 1515721 R 28985 CDS KLLA0_E17095g 2893768 1519323..1521395 E 1 NC_006041.1 similar to uniprot|Q06683 Saccharomyces cerevisiae YDR332W Hypothetical ORF; double-stranded DNA-dependent ATPase 1521395 2893768 KLLA0_E17095g Kluyveromyces lactis double-stranded DNA-dependent ATPase XP_454720.1 1519323 D 28985 CDS KLLA0_E17117g 2893769 1521682..1522686 E 1 NC_006041.1 weakly similar to uniprot|P14693 Saccharomyces cerevisiae YHR083W SAM35 Essential component of the sorting and assembly machinery (SAM complex aka TOB complex) of the mitochondrial outer membrane which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane; SAM complex subunit SAM35 1522686 2893769 KLLA0_E17117g Kluyveromyces lactis SAM complex subunit SAM35 XP_454721.1 1521682 D 28985 CDS KLLA0_E17139g 2894276 1523750..1525750 E 1 NC_006041.1 uniprot|Q08400 Kluyveromyces lactis STE12 Protein STE12; homeodomain family transcription factor STE12 1525750 2894276 KLLA0_E17139g Kluyveromyces lactis homeodomain family transcription factor STE12 XP_454722.1 1523750 D 28985 CDS KLLA0_E17161g 2893770 1526177..1527430 E 1 NC_006041.1 similar to uniprot|P38211 Saccharomyces cerevisiae YBR004C GPI18 Functional ortholog of human PIG-V which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis the authentic non-tagged protein was localized to mitochondria; GPI-anchor transamidase GPI18 1527430 2893770 KLLA0_E17161g Kluyveromyces lactis GPI-anchor transamidase GPI18 XP_454723.1 1526177 D 28985 CDS KLLA0_E17183g 2893771 complement(1527770..1529203) E 1 NC_006041.1 highly similar to uniprot|P18900 Saccharomyces cerevisiae YBR003W COQ1 Hexaprenyl pyrophosphate synthetase catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis; trans-hexaprenyltranstransferase 1529203 2893771 KLLA0_E17183g Kluyveromyces lactis trans-hexaprenyltranstransferase XP_454724.1 1527770 R 28985 CDS KLLA0_E17205g 2893628 1530035..1530862 E 1 NC_006041.1 similar to uniprot|P35196 Saccharomyces cerevisiae YBR002C RER2 Cis-prenyltransferase involved in dolichol synthesis participates in endoplasmic reticulum (ER) protein sorting; ditrans,polycis-polyprenyl diphosphate synthase 1530862 2893628 KLLA0_E17205g Kluyveromyces lactis ditrans,polycis-polyprenyl diphosphate synthase XP_454725.1 1530035 D 28985 CDS KLLA0_E17227g 2893629 complement(1531243..1531854) E 1 NC_006041.1 similar to uniprot|P41920 Saccharomyces cerevisiae YDR002W YRB1 Yeast Ran Binder #1 suppressor of FUS1 homolog of mouse HTF9a and human RanBP1 nuclear GTPase- activating protein for Ran; Ran GTPase-binding protein YRB1 1531854 2893629 KLLA0_E17227g Kluyveromyces lactis Ran GTPase-binding protein YRB1 XP_454726.1 1531243 R 28985 CDS KLLA0_E17249g 2893630 1532193..1532567 E 1 NC_006041.1 no similarity; uncharacterized protein 1532567 2893630 KLLA0_E17249g Kluyveromyces lactis uncharacterized protein XP_454727.1 1532193 D 28985 CDS KLLA0_E17271g 2894277 1533054..1535318 E 1 NC_006041.1 highly similar to uniprot|P32356 Saccharomyces cerevisiae YDR001C NTH1 Neutral trehalase degrades trehalose required for thermotolerance and may mediate resistance to other cellular stresses may be phosphorylated by Cdc28p; uncharacterized protein 1535318 2894277 KLLA0_E17271g Kluyveromyces lactis uncharacterized protein XP_454728.1 1533054 D 28985 CDS KLLA0_E17293g 2893631 1535737..1536822 E 1 NC_006041.1 no similarity; uncharacterized protein 1536822 2893631 KLLA0_E17293g Kluyveromyces lactis uncharacterized protein XP_454729.1 1535737 D 28985 CDS KLLA0_E17315g 9487485 join(1537446..1537487,1537614..1537886) E 1 NC_006041.1 highly similar to uniprot|P35195 Saccharomyces cerevisiae YBL001C ECM15 Non-essential protein of unknown function; uncharacterized protein 1537886 9487485 KLLA0_E17315g Kluyveromyces lactis uncharacterized protein XP_002999407.1 1537446 D 28985 CDS KLLA0_E17337g 2893742 complement(1538169..1538567) E 1 NC_006041.1 similar to uniprot|P02293 Saccharomyces cerevisiae YDR224C HTB1 One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation meiotic DSB formation and H3 methylation and similar to YBL002W uniprot|P02294 Saccharomyces cerevisiae YBL002W HTB2 One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation; histone H2B 1538567 2893742 KLLA0_E17337g Kluyveromyces lactis histone H2B XP_454731.1 1538169 R 28985 CDS KLLA0_E17359g 2893743 1539714..1540106 E 1 NC_006041.1 similar to uniprot|P04911 Saccharomyces cerevisiae YDR225W HTA1 One of two nearly identical (see also HTA2) histone H2A subtypes core histone required for chromatin assembly and chromosome function DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair acetylated by Nat4p and similar to YBL003C uniprot|P04912 Saccharomyces cerevisiae YBL003C HTA2 One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage- dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p; histone H2A 1540106 2893743 KLLA0_E17359g Kluyveromyces lactis histone H2A XP_454732.1 1539714 D 28985 CDS KLLA0_E17381g 2893744 complement(1540387..1541721) E 1 NC_006041.1 similar to uniprot|Q05210 Saccharomyces cerevisiae YDL001W RMD1 Cytoplasmic protein required for sporulation; uncharacterized protein 1541721 2893744 KLLA0_E17381g Kluyveromyces lactis uncharacterized protein XP_454733.1 1540387 R 28985 CDS KLLA0_E17403g 2893745 1542238..1542975 E 1 NC_006041.1 similar to uniprot|Q03435 Saccharomyces cerevisiae YDL002C NHP10 Protein related to mammalian high mobility group proteins likely component of the INO80 complex which is an ATP-dependent chromatin-remodeling complex; uncharacterized protein 1542975 2893745 KLLA0_E17403g Kluyveromyces lactis uncharacterized protein XP_454734.1 1542238 D 28985 CDS KLLA0_E17425g 2893746 complement(1543158..1550639) E 1 NC_006041.1 similar to uniprot|P35194 Saccharomyces cerevisiae YBL004W UTP20 Possible snoRNA-binding protein based on computational analysis of large-scale protein-protein interaction data; uncharacterized protein 1550639 2893746 KLLA0_E17425g Kluyveromyces lactis uncharacterized protein XP_454735.1 1543158 R 28985 CDS KLLA0_E17447g 2893747 1551621..1552259 E 1 NC_006041.1 weakly similar to uniprot|Q03446 Saccharomyces cerevisiae YDR003W; uncharacterized protein 1552259 2893747 KLLA0_E17447g Kluyveromyces lactis uncharacterized protein XP_454736.1 1551621 D 28985 CDS KLLA0_E17469g 2893736 1552950..1553492 E 1 NC_006041.1 some similarities with uniprot|Q03446 Saccharomyces cerevisiae YDR003W; uncharacterized protein 1553492 2893736 KLLA0_E17469g Kluyveromyces lactis uncharacterized protein XP_454737.1 1552950 D 28985 CDS KLLA0_E17491g 2893737 1553982..1555475 E 1 NC_006041.1 highly similar to uniprot|P38067 Saccharomyces cerevisiae YBR006W UGA2 Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source part of the 4-aminobutyrate and glutamate degradation pathways localized to the cytoplasm; succinate-semialdehyde dehydrogenase (NAD(P)(+)) 1555475 2893737 KLLA0_E17491g Kluyveromyces lactis succinate-semialdehyde dehydrogenase (NAD(P)(+)) XP_454738.1 1553982 D 28985 CDS KLLA0_E17513g 2893738 1555877..1557319 E 1 NC_006041.1 similar to uniprot|P25301 Saccharomyces cerevisiae YDR004W RAD57 Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis forms heterodimer with Rad55p; uncharacterized protein 1557319 2893738 KLLA0_E17513g Kluyveromyces lactis uncharacterized protein XP_454739.1 1555877 D 28985 CDS KLLA0_E17535g 9487367 complement(1557680..1558669) E 1 NC_006041.1 similar to uniprot|P41910 Saccharomyces cerevisiae YDR005C MAF1 Negative regulator of RNA polymerase III component of several signaling pathways that repress polymerase III transcription in response to changes in cellular environment targets the initiation factor TFIIIB; RNA polymerase III-inhibiting protein MAF1 1558669 9487367 KLLA0_E17535g Kluyveromyces lactis RNA polymerase III-inhibiting protein MAF1 XP_002999408.1 1557680 R 28985 CDS KLLA0_E17557g 2893740 complement(1559577..1561637) E 1 NC_006041.1 weakly similar to YBR007C, uniprot|P38213 Saccharomyces cerevisiae YBR007C (DSF2); uncharacterized protein 1561637 2893740 KLLA0_E17557g Kluyveromyces lactis uncharacterized protein XP_454741.1 1559577 R 28985 CDS KLLA0_E17579g 2894114 complement(1562195..1565467) E 1 NC_006041.1 similar to uniprot|P40317 Saccharomyces cerevisiae YDR006C (SOK1); uncharacterized protein 1565467 2894114 KLLA0_E17579g Kluyveromyces lactis uncharacterized protein XP_454742.1 1562195 R 28985 CDS KLLA0_E17601g 9487384 complement(1566673..1566984) E 1 NC_006041.1 highly similar to uniprot|P02309 Saccharomyces cerevisiae YBR009C HHF1 and highly similar to uniprot|P02309 Saccharomyces cerevisiae YNL030W HHF2, two identical histone H4 proteins; core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity; histone H4 1566984 9487384 KLLA0_E17601g Kluyveromyces lactis histone H4 XP_002999409.1 1566673 R 28985 CDS KLLA0_E17623g 2894116 1567814..1568224 E 1 NC_006041.1 highly similar to uniprot|P02303 Saccharomyces cerevisiae YNL031C HHT2 and highly similar to uniprot|P02303 Saccharomyces cerevisiae YBR010W HHT1 histone H3 proteins; histone H3 1568224 2894116 KLLA0_E17623g Kluyveromyces lactis histone H3 XP_454744.1 1567814 D 28985 CDS KLLA0_E17645g 2894278 1568538..1569170 E 1 NC_006041.1 similar to uniprot|P00912 Saccharomyces cerevisiae YDR007W TRP1 Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis in 2004 the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA); phosphoribosylanthranilate isomerase TRP1 1569170 2894278 KLLA0_E17645g Kluyveromyces lactis phosphoribosylanthranilate isomerase TRP1 XP_454745.1 1568538 D 28985 CDS KLLA0_E17667g 2894279 complement(1569250..1570233) E 1 NC_006041.1 highly similar to uniprot|P00817 Saccharomyces cerevisiae YBR011C IPP1 Cytoplasmic inorganic pyrophosphatase (PPase) catalyzes the rapid exchange of oxygens from Pi with water highly expressed and essential for viability active-site residues show identity to those from E. coli PPase; inorganic diphosphatase IPP1 1570233 2894279 KLLA0_E17667g Kluyveromyces lactis inorganic diphosphatase IPP1 XP_454746.1 1569250 R 28985 CDS KLLA0_E17711g 2894124 complement(1571018..1571506) E 1 NC_006041.1 similar to uniprot|Q12157 Saccharomyces cerevisiae YDL008W APC11 Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition; anaphase promoting complex subunit 11 1571506 2894124 KLLA0_E17711g Kluyveromyces lactis anaphase promoting complex subunit 11 XP_454749.1 1571018 R 28985 CDS KLLA0_E17733g 2894125 complement(1571724..1572359) E 1 NC_006041.1 similar to Saccharomyces cerevisiae YDL010W Hypothetical ORF or YBR014C uniprot|P38068 Saccharomyces cerevisiae YBR014C Hypothetical ORF; uncharacterized protein 1572359 2894125 KLLA0_E17733g Kluyveromyces lactis uncharacterized protein XP_454750.1 1571724 R 28985 CDS KLLA0_E17755g 2894126 complement(1572985..1574901) E 1 NC_006041.1 similar to uniprot|P38069 Saccharomyces cerevisiae YBR015C MNN2 Alpha-1 2-mannosyltransferase responsible for addition of the first alpha-1 2-linked mannose to form the branches on the mannan backbone of oligosaccharides localizes to an early Golgi compartment; alpha-1,2-mannosyltransferase MNN2 1574901 2894126 KLLA0_E17755g Kluyveromyces lactis alpha-1,2-mannosyltransferase MNN2 XP_454751.1 1572985 R 28985 CDS KLLA0_E17777g 2894127 complement(1575809..1578121) E 1 NC_006041.1 similar to uniprot|Q12387 Saccharomyces cerevisiae YOL076W MDM20 Subunit of the NatB N-terminal acetyltransferase which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met involved in mitochondrial inheritance and actin assembly; uncharacterized protein 1578121 2894127 KLLA0_E17777g Kluyveromyces lactis uncharacterized protein XP_454752.1 1575809 R 28985 CDS KLLA0_E17799g 2894128 1578734..1579630 E 1 NC_006041.1 highly similar to uniprot|Q08235 Saccharomyces cerevisiae YOL077C BRX1 Nucleolar protein involved in the biogenesis of large ribosomal subunits depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits possesses a sigma(70)-like RNA-binding motif; ribosome biogenesis protein BRX1 1579630 2894128 KLLA0_E17799g Kluyveromyces lactis ribosome biogenesis protein BRX1 XP_454753.1 1578734 D 28985 CDS KLLA0_E17821g 2893920 1581075..1582550 E 1 NC_006041.1 similar to uniprot|P38109 Saccharomyces cerevisiae YBR139W Hypothetical ORF; uncharacterized protein 1582550 2893920 KLLA0_E17821g Kluyveromyces lactis uncharacterized protein XP_454754.1 1581075 D 28985 CDS KLLA0_E17843g 2893921 complement(1582644..1585943) E 1 NC_006041.1 weakly similar to uniprot|Q08236 Saccharomyces cerevisiae YOL078W AVO1 Component of a membrane-bound complex containing the Tor2p kinase and other proteins which may have a role in regulation of cell growth; uncharacterized protein 1585943 2893921 KLLA0_E17843g Kluyveromyces lactis uncharacterized protein XP_454755.1 1582644 R 28985 CDS KLLA0_E17865g 2893922 1586485..1587369 E 1 NC_006041.1 similar to uniprot|Q08237 Saccharomyces cerevisiae YOL080C REX4 Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly; uncharacterized protein 1587369 2893922 KLLA0_E17865g Kluyveromyces lactis uncharacterized protein XP_454756.1 1586485 D 28985 CDS KLLA0_E17887g 2893923 complement(1587614..1596283) E 1 NC_006041.1 similar to uniprot|P18963 Saccharomyces cerevisiae YBR140c IRA1 or uniprot|P19158 Saccharomyces cerevisiae YOL081w IRA2; Ras GTPase activating protein IRA2 1596283 2893923 KLLA0_E17887g Kluyveromyces lactis Ras GTPase activating protein IRA2 XP_454757.1 1587614 R 28985 CDS KLLA0_E17909g 2893924 complement(1596954..1597970) E 1 NC_006041.1 some similarities with uniprot|P53938 Saccharomyces cerevisiae YNL080C; uncharacterized protein 1597970 2893924 KLLA0_E17909g Kluyveromyces lactis uncharacterized protein XP_454758.1 1596954 R 28985 CDS KLLA0_E17931g 9487462 complement(join(1598775..1599242,1599482..1599499)) E 1 NC_006041.1 similar to uniprot|P40414 Saccharomyces cerevisiae YIL138C TPM2 Tropomyosin isoform 2 actin-binding protein that stabilizes actin filaments required with Tpm1 the main tropomyosin for the formation and stability of actin cables in vivo which direct polarized cell growth and the distribution of several organelles; uncharacterized protein 1599499 9487462 KLLA0_E17931g Kluyveromyces lactis uncharacterized protein XP_002999410.1 1598775 R 28985 CDS KLLA0_E17953g 2894242 complement(1600015..1603470) E 1 NC_006041.1 similar to uniprot|P40578 MGA2 and to YKL020C uniprot|P35210 SPT23, Saccharomyces cerevisiae ER membrane proteins involved in regulation of OLE1 transcription; uncharacterized protein 1603470 2894242 KLLA0_E17953g Kluyveromyces lactis uncharacterized protein XP_454760.1 1600015 R 28985 CDS KLLA0_E17975g 2894243 1604192..1605133 E 1 NC_006041.1 similar to uniprot|P29703 Saccharomyces cerevisiae YKL019W RAM2 CAAX farnesyltransferase alpha subunit; bifunctional protein farnesyltransferase/protein geranylgeranyltransferase 1605133 2894243 KLLA0_E17975g Kluyveromyces lactis bifunctional protein farnesyltransferase/protein geranylgeranyltransferase XP_454761.1 1604192 D 28985 CDS KLLA0_E17997g 2894244 1605435..1606502 E 1 NC_006041.1 similar to uniprot|Q02256 Saccharomyces cerevisiae YIR026C YVH1 nitrogen starvation-induced protein phosphatase; tyrosine protein phosphatase YVH1 1606502 2894244 KLLA0_E17997g Kluyveromyces lactis tyrosine protein phosphatase YVH1 XP_454762.1 1605435 D 28985 CDS KLLA0_E18019g 2893853 complement(1606595..1607410) E 1 NC_006041.1 weakly similar to uniprot|P40577 Saccharomyces cerevisiae YIR025W MND2 Subunit of the anaphase-promoting complex (APC) needed for meiotic nuclear division; uncharacterized protein 1607410 2893853 KLLA0_E18019g Kluyveromyces lactis uncharacterized protein XP_454763.1 1606595 R 28985 CDS KLLA0_E18041g 2893854 complement(join(1607729..1607980,1608097..1608102)) E 1 NC_006041.1 weakly similar to YKL018c-a, Hypothetical ORF; uncharacterized protein 1608102 2893854 KLLA0_E18041g Kluyveromyces lactis uncharacterized protein XP_454764.1 1607729 R 28985 CDS KLLA0_E18063g 2893855 1608371..1609351 E 1 NC_006041.1 highly similar to uniprot|P36104 Saccharomyces cerevisiae YKL018W SWD2 Subunit of the COMPASS complex which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD-repeat containing protein SWD2 1609351 2893855 KLLA0_E18063g Kluyveromyces lactis WD-repeat containing protein SWD2 XP_454765.1 1608371 D 28985 CDS KLLA0_E18085g 2893856 complement(1609333..1611378) E 1 NC_006041.1 similar to uniprot|P34243 Saccharomyces cerevisiae YKL017C HCS1 Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis contains single-stranded DNA stimulated ATPase and dATPase activities replication protein A stimulates helicase and ATPase activities; ATP-dependent 5'-3' DNA helicase HCS1 1611378 2893856 KLLA0_E18085g Kluyveromyces lactis ATP-dependent 5'-3' DNA helicase HCS1 XP_454766.1 1609333 R 28985 CDS KLLA0_E18107g 2894292 complement(1611632..1612156) E 1 NC_006041.1 highly similar to uniprot|P30902 Saccharomyces cerevisiae YKL016C ATP7 Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis; F1F0 ATP synthase subunit d 1612156 2894292 KLLA0_E18107g Kluyveromyces lactis F1F0 ATP synthase subunit d XP_454767.1 1611632 R 28985 CDS KLLA0_E18129g 2893857 1613115..1615712 E 1 NC_006041.1 similar to uniprot|P25502 Saccharomyces cerevisiae YKL015W PUT3 Positive regulator of PUT (proline utilization) genes zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; uncharacterized protein 1615712 2893857 KLLA0_E18129g Kluyveromyces lactis uncharacterized protein XP_454768.1 1613115 D 28985 CDS KLLA0_E18151g 2894448 complement(1615820..1620910) E 1 NC_006041.1 similar to uniprot|P34241 Saccharomyces cerevisiae YKL014C URB1 Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs associated with the 27SA2 pre-ribosomal particle proposed to be involved in the biogenesis of the 60S ribosomal subunit; uncharacterized protein 1620910 2894448 KLLA0_E18151g Kluyveromyces lactis uncharacterized protein XP_454769.1 1615820 R 28985 CDS KLLA0_E18173g 2894449 1621494..1622186 E 1 NC_006041.1 similar to uniprot|P40576 Saccharomyces cerevisiae YIR024C (putative) involved in cell cycle control; uncharacterized protein 1622186 2894449 KLLA0_E18173g Kluyveromyces lactis uncharacterized protein XP_454770.1 1621494 D 28985 CDS KLLA0_E18195g 2894450 complement(1622300..1625701) E 1 NC_006041.1 similar to uniprot|P21657 Saccharomyces cerevisiae YIR023W DAL81 Positive regulator of genes in multiple nitrogen degradation pathways contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism; uncharacterized protein 1625701 2894450 KLLA0_E18195g Kluyveromyces lactis uncharacterized protein XP_454771.1 1622300 R 28985 CDS KLLA0_E18217g 2894451 complement(1626079..1626594) E 1 NC_006041.1 highly similar to uniprot|P33204 Saccharomyces cerevisiae YKL013C ARC19 Subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches; uncharacterized protein 1626594 2894451 KLLA0_E18217g Kluyveromyces lactis uncharacterized protein XP_454772.1 1626079 R 28985 CDS KLLA0_E18239g 2894452 1627093..1628808 E 1 NC_006041.1 similar to uniprot|P33203 Saccharomyces cerevisiae YKL012W PRP40 U1 snRNP protein involved in splicing interacts with the branchpoint-binding protein during the formation of the second commitment complex; uncharacterized protein 1628808 2894452 KLLA0_E18239g Kluyveromyces lactis uncharacterized protein XP_454773.1 1627093 D 28985 CDS KLLA0_E18261g 2894751 complement(1628878..1629387) E 1 NC_006041.1 highly similar to uniprot|P15367 Saccharomyces cerevisiae YIR022W SEC11 18kDa catalytic subunit of the Signal Peptidase Complex (SPC Spc1p Spc2p Spc3p and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum; signal peptidase complex catalytic subunit SEC11 1629387 2894751 KLLA0_E18261g Kluyveromyces lactis signal peptidase complex catalytic subunit SEC11 XP_454774.1 1628878 R 28985 CDS KLLA0_E18283g 2894752 1629714..1630394 E 1 NC_006041.1 similar to uniprot|Q04304 Saccharomyces cerevisiae YMR090W Hypothetical ORF; uncharacterized protein 1630394 2894752 KLLA0_E18283g Kluyveromyces lactis uncharacterized protein XP_454775.1 1629714 D 28985 CDS KLLA0_E18305g 2894753 complement(1630521..1631597) E 1 NC_006041.1 weakly similar to uniprot|Q03702 Saccharomyces cerevisiae YKL011C CCE1 cruciform cutting endonuclease; cruciform cutting endonuclease 1631597 2894753 KLLA0_E18305g Kluyveromyces lactis cruciform cutting endonuclease XP_454776.1 1630521 R 28985 CDS KLLA0_E18327g 2894754 1631929..1632564 E 1 NC_006041.1 no similarity; uncharacterized protein 1632564 2894754 KLLA0_E18327g Kluyveromyces lactis uncharacterized protein XP_454777.1 1631929 D 28985 CDS KLLA0_E18349g 2894755 1632967..1634598 E 1 NC_006041.1 some similarities with uniprot|P36076 Saccharomyces cerevisiae YKL088W Protein required for cell viability; phosphopantothenoylcysteine decarboxylase complex subunit CAB3 1634598 2894755 KLLA0_E18349g Kluyveromyces lactis phosphopantothenoylcysteine decarboxylase complex subunit CAB3 XP_454778.1 1632967 D 28985 CDS KLLA0_E18371g 2894522 1635391..1637427 E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 1637427 2894522 KLLA0_E18371g Kluyveromyces lactis uncharacterized protein XP_454779.1 1635391 D 28985 CDS KLLA0_E18393g 2894523 complement(1638238..1638966) E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 1638966 2894523 KLLA0_E18393g Kluyveromyces lactis uncharacterized protein XP_454780.1 1638238 R 28985 CDS KLLA0_E18415g 2894524 complement(1639415..1640116) E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 1640116 2894524 KLLA0_E18415g Kluyveromyces lactis uncharacterized protein XP_454781.1 1639415 R 28985 CDS KLLA0_E18459g 2894527 1641507..1641953 E 1 NC_006041.1 similar to uniprot|Q59TA9 Candida albicans CaO19 Potential heme/steroid binding protein and some similarites with YMR073C uniprot|Q04772 Saccharomyces cerevisiae YMR073C Hypothetical ORF; uncharacterized protein 1641953 2894527 KLLA0_E18459g Kluyveromyces lactis uncharacterized protein XP_454784.1 1641507 D 28985 CDS KLLA0_E18481g 2894476 complement(1642554..1643948) E 1 NC_006041.1 some similarities with uniprot|P33417 Saccharomyces cerevisiae YKL032C IXR1 Protein that binds DNA containing intrastrand cross-links formed by cisplatin contains two HMG (high mobility group box) domains which confer the ability to bend cisplatin-modified DNA mediates aerobic transcriptional repression of COX5b; DNA-binding transcription repressor IXR1 1643948 2894476 KLLA0_E18481g Kluyveromyces lactis DNA-binding transcription repressor IXR1 XP_454785.1 1642554 R 28985 CDS KLLA0_E18503g 2894478 complement(1645113..1647065) E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 1647065 2894478 KLLA0_E18503g Kluyveromyces lactis uncharacterized protein XP_454787.1 1645113 R 28985 CDS KLLA0_E18525g 2894479 1647606..1648121 E 1 NC_006041.1 similar to uniprot|Q04767 Saccharomyces cerevisiae YMR071C TVP18 Tlg2-Vesicle Protein of 18 kDa Integral membrane vesicle protein; uncharacterized protein 1648121 2894479 KLLA0_E18525g Kluyveromyces lactis uncharacterized protein XP_454788.1 1647606 D 28985 CDS KLLA0_E18547g 2894480 complement(1648263..1649558) E 1 NC_006041.1 some similarities with uniprot|P54785 Saccharomyces cerevisiae YMR070W MOT3 Nuclear transcription factor with two Cys2-His2 zinc fingers involved in repression of a subset of hypoxic genes by Rox1p repression of several DAN/TIR genes during aerobic growth and repression of ergosterol biosynthetic genes; uncharacterized protein 1649558 2894480 KLLA0_E18547g Kluyveromyces lactis uncharacterized protein XP_454789.1 1648263 R 28985 CDS KLLA0_E18569g 2894149 complement(1651949..1652596) E 1 NC_006041.1 no similarity; uncharacterized protein 1652596 2894149 KLLA0_E18569g Kluyveromyces lactis uncharacterized protein XP_454790.1 1651949 R 28985 CDS KLLA0_E18613g 2894151 1652892..1654016 E 1 NC_006041.1 similar to uniprot|Q750M6 Ashbya gossypii AGL070W AGL070Wp and weakly similar to YHR004C uniprot|P38757 Saccharomyces cerevisiae YHR004C NEM1 Protein of the nuclear envelope required for the spherical shape of the nucleus required for normal sporulation; Nem1-Spo7 phosphatase catalytic subunit NEM1 1654016 2894151 KLLA0_E18613g Kluyveromyces lactis Nem1-Spo7 phosphatase catalytic subunit NEM1 XP_454792.1 1652892 D 28985 CDS KLLA0_E18635g 2894152 1654950..1656872 E 1 NC_006041.1 highly similar to uniprot|P36013 Saccharomyces cerevisiae YKL029C MAE1 Mitochondrial malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids; malate dehydrogenase (oxaloacetate-decarboxylating) 1656872 2894152 KLLA0_E18635g Kluyveromyces lactis malate dehydrogenase (oxaloacetate-decarboxylating) XP_454793.1 1654950 D 28985 CDS KLLA0_E18657g 2894153 1657394..1658986 E 1 NC_006041.1 similar to uniprot|Q750M4 Ashbya gossypii AGL067W AGL067Wp and some similarites with YKL028W uniprot|P36100 Saccharomyces cerevisiae YKL028W TFA1 TFIIE large subunit involved in recruitment of RNA polymerase II to the promoter activation of TFIIH and promoter opening; transcription factor TFIIE subunit TFA1 1658986 2894153 KLLA0_E18657g Kluyveromyces lactis transcription factor TFIIE subunit TFA1 XP_454794.1 1657394 D 28985 CDS KLLA0_E18679g 2893705 1659258..1660598 E 1 NC_006041.1 similar to uniprot|P36101 Saccharomyces cerevisiae YKL027W Hypothetical ORF; tRNA threonylcarbamoyladenosine dehydratase 1660598 2893705 KLLA0_E18679g Kluyveromyces lactis tRNA threonylcarbamoyladenosine dehydratase XP_454795.1 1659258 D 28985 CDS KLLA0_E18701g 2893748 complement(1661093..1662238) E 1 NC_006041.1 similar to uniprot|P38702 Saccharomyces cerevisiae YHR002W LEU5 Mitochondrial carrier protein involved in the accumulation of CoA in the mitochondrial matrix homolog of human Graves disease protein does not encode an isozyme of Leu4p as first hypothesized; coenzyme A transporter 1662238 2893748 KLLA0_E18701g Kluyveromyces lactis coenzyme A transporter XP_454796.1 1661093 R 28985 CDS KLLA0_E18723g 2893749 1663220..1664353 E 1 NC_006041.1 highly similar to uniprot|P38152 Saccharomyces cerevisiae YBR291C CTP1 Mitochondrial inner membrane citrate transporter member of the mitochondrial carrier family; uncharacterized protein 1664353 2893749 KLLA0_E18723g Kluyveromyces lactis uncharacterized protein XP_454797.1 1663220 D 28985 CDS KLLA0_E18745g 2893750 complement(1664971..1665921) E 1 NC_006041.1 similar to uniprot|P38356 Saccharomyces cerevisiae YBR290W BSD2 Heavy metal ion homeostasis protein facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded controls metal ion transport prevents metal hyperaccumulation functions in copper detoxification; uncharacterized protein 1665921 2893750 KLLA0_E18745g Kluyveromyces lactis uncharacterized protein XP_454798.1 1664971 R 28985 CDS KLLA0_E18767g 2893751 complement(1666322..1668724) E 1 NC_006041.1 some similarities with uniprot|P18480 Saccharomyces cerevisiae YBR289W SNF5 Involved in global regulation of transcription subunit of the chromatin remodeling Snf/Swi complex; uncharacterized protein 1668724 2893751 KLLA0_E18767g Kluyveromyces lactis uncharacterized protein XP_454799.1 1666322 R 28985 CDS KLLA0_E18789g 2893752 1669103..1670596 E 1 NC_006041.1 similar to uniprot|P38153 Saccharomyces cerevisiae YBR288C APM3 Mu3-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway clathrin associated protein medium chain; uncharacterized protein 1670596 2893752 KLLA0_E18789g Kluyveromyces lactis uncharacterized protein XP_454800.1 1669103 D 28985 CDS KLLA0_E18811g 2893980 1670923..1672263 E 1 NC_006041.1 similar to uniprot|Q6B1X3 Saccharomyces cerevisiae YPL181W CTI6 Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter contains a PHD finger domain; uncharacterized protein 1672263 2893980 KLLA0_E18811g Kluyveromyces lactis uncharacterized protein XP_454801.1 1670923 D 28985 CDS KLLA0_E18833g 2893981 complement(1672341..1674074) E 1 NC_006041.1 similar to uniprot|P38932 Saccharomyces cerevisiae YGL095C VPS45 Protein of the Sec1p family essential for vacuolar protein sorting required for the function of both Pep12p and the early endosome/late Golgi SNARE Tlg2p; uncharacterized protein 1674074 2893981 KLLA0_E18833g Kluyveromyces lactis uncharacterized protein XP_454802.1 1672341 R 28985 CDS KLLA0_E18855g 2893982 1674432..1676600 E 1 NC_006041.1 weakly similar to uniprot|Q08921 Saccharomyces cerevisiae YPL180W TCO89 Tor Complex One; uncharacterized protein 1676600 2893982 KLLA0_E18855g Kluyveromyces lactis uncharacterized protein XP_454803.1 1674432 D 28985 CDS KLLA0_E18877g 2893983 complement(1676876..1680310) E 1 NC_006041.1 similar to uniprot|P53010 Saccharomyces cerevisiae YGL094C PAN2 Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes; poly(A)-specific ribonuclease 1680310 2893983 KLLA0_E18877g Kluyveromyces lactis poly(A)-specific ribonuclease XP_454804.1 1676876 R 28985 CDS KLLA0_E18899g 2893984 1680775..1683747 E 1 NC_006041.1 similar to uniprot|Q08924 Saccharomyces cerevisiae YPL183C Hypothetical ORF; uncharacterized protein 1683747 2893984 KLLA0_E18899g Kluyveromyces lactis uncharacterized protein XP_454805.1 1680775 D 28985 CDS KLLA0_E18921g 2893967 complement(1683925..1684167) E 1 NC_006041.1 similar to uniprot|O14464 Saccharomyces cerevisiae YPL183W-A, ribosomal protein L36, likely to be a mitochondrial ribosomal protein coded in the nuclear genome; mitochondrial 54S ribosomal protein bL36m 1684167 2893967 KLLA0_E18921g Kluyveromyces lactis mitochondrial 54S ribosomal protein bL36m XP_454806.1 1683925 R 28985 CDS KLLA0_E18943g 2893968 1684751..1687216 E 1 NC_006041.1 weakly similar to uniprot|P53148 Saccharomyces cerevisiae YGL093W SPC105 Protein required for accurate chromosome segregation; uncharacterized protein 1687216 2893968 KLLA0_E18943g Kluyveromyces lactis uncharacterized protein XP_454807.1 1684751 D 28985 CDS KLLA0_E18965g 2893969 1687547..1691506 E 1 NC_006041.1 weakly similar to uniprot|P49687 Saccharomyces cerevisiae YGL092W NUP145 Essential nucleoporin catalyzes its own cleavage in vivo to generate a C-terminal fragment that assembles into the Nup84p subcomplex of the nuclear pore complex; nucleocytoplasmic transporter NUP145 1691506 2893969 KLLA0_E18965g Kluyveromyces lactis nucleocytoplasmic transporter NUP145 XP_454808.1 1687547 D 28985 CDS KLLA0_E18987g 2893970 complement(1691643..1692623) E 1 NC_006041.1 highly similar to uniprot|P52920 Saccharomyces cerevisiae YGL091C NBP35 Essential nuclear protein evolutionarily conserved putative ATPase exhibits genetic interaction with CDC2 encoding the catalytic subunit of DNA polymerase delta; Fe-S cluster-binding ATPase 1692623 2893970 KLLA0_E18987g Kluyveromyces lactis Fe-S cluster-binding ATPase XP_454809.1 1691643 R 28985 CDS KLLA0_E19009g 2893973 1692900..1693718 E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 1693718 2893973 KLLA0_E19009g Kluyveromyces lactis uncharacterized protein XP_454810.1 1692900 D 28985 CDS KLLA0_E19031g 2893974 1694566..1696524 E 1 NC_006041.1 similar to uniprot|Q08925 Saccharomyces cerevisiae YPL184C Hypothetical ORF; uncharacterized protein 1696524 2893974 KLLA0_E19031g Kluyveromyces lactis uncharacterized protein XP_454811.1 1694566 D 28985 CDS KLLA0_E19053g 2893976 1697655..1698314 E 1 NC_006041.1 some similarities with uniprot|Q08926 Saccharomyces cerevisiae YPL186C UIP4 Protein of unknown function; uncharacterized protein 1698314 2893976 KLLA0_E19053g Kluyveromyces lactis uncharacterized protein XP_454813.1 1697655 D 28985 CDS KLLA0_E19075g 2893977 complement(1698739..1699302) E 1 NC_006041.1 similar to uniprot|P01149 Saccharomyces cerevisiae YPL187W MF(ALPHA)1 Mating pheromone alpha-factor made by alpha cells interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating also encoded by MF(ALPHA)2 although MF(ALPHA)1 produces most alpha-factor; uncharacterized protein 1699302 2893977 KLLA0_E19075g Kluyveromyces lactis uncharacterized protein XP_454814.1 1698739 R 28985 CDS KLLA0_E19097g 2893953 complement(1700712..1701974) E 1 NC_006041.1 highly similar to uniprot|Q06892 Saccharomyces cerevisiae YPL188W POS5 Mitochondrial NADH kinase phosphorylates NADH also phosphorylates NAD() with lower specificity required for the response to oxidative stress; NADH kinase 1701974 2893953 KLLA0_E19097g Kluyveromyces lactis NADH kinase XP_454815.1 1700712 R 28985 CDS KLLA0_E19119g 2893954 complement(join(1702717..1703125,1703226..1703236)) E 1 NC_006041.1 highly similar to uniprot|P53152 Saccharomyces cerevisiae YGL087C MMS2 Protein involved in error-free postreplication DNA repair forms a heteromeric complex with Ubc13p that has a ubiquitin-conjugating activity cooperates with chromatin-associated RING finger proteins Rad18p and Rad5p; E2 ubiquitin-conjugating protein MMS2 1703236 2893954 KLLA0_E19119g Kluyveromyces lactis E2 ubiquitin-conjugating protein MMS2 XP_454816.1 1702717 R 28985 CDS KLLA0_E19141g 2893955 1703466..1705412 E 1 NC_006041.1 similar to uniprot|P40957 Saccharomyces cerevisiae YGL086W MAD1 Coiled-coil protein involved in the spindle-assembly checkpoint phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex forms a complex with Mad2p; coiled-coil domain-containing protein MAD1 1705412 2893955 KLLA0_E19141g Kluyveromyces lactis coiled-coil domain-containing protein MAD1 XP_454817.1 1703466 D 28985 CDS KLLA0_E19163g 2893956 1705629..1706441 E 1 NC_006041.1 similar to uniprot|P53153 Saccharomyces cerevisiae YGL085W Hypothetical ORF; uncharacterized protein 1706441 2893956 KLLA0_E19163g Kluyveromyces lactis uncharacterized protein XP_454818.1 1705629 D 28985 CDS KLLA0_E19185g 2894679 complement(1706645..1708408) E 1 NC_006041.1 similar to uniprot|P53154 Saccharomyces cerevisiae YGL084C GUP1 Multimembrane-spanning protein or to uniprot|Q08929 Saccharomyces cerevisiae YPL189w active glycerol transporter (putative); uncharacterized protein 1708408 2894679 KLLA0_E19185g Kluyveromyces lactis uncharacterized protein XP_454819.1 1706645 R 28985 CDS KLLA0_E19207g 2894680 1709335..1711638 E 1 NC_006041.1 similar to uniprot|P53009 Saccharomyces cerevisiae YGL083W SCY1 Suppressor of GTPase mutant; uncharacterized protein 1711638 2894680 KLLA0_E19207g Kluyveromyces lactis uncharacterized protein XP_454820.1 1709335 D 28985 CDS KLLA0_E19229g 2894681 1713099..1715318 E 1 NC_006041.1 similar to uniprot|P38996 Saccharomyces cerevisiae YPL190C NAB3 Single stranded DNA binding protein acidic ribonucleoprotein required for termination of non-poly(A) transcripts and efficient splicing interacts with Nrd1p; uncharacterized protein 1715318 2894681 KLLA0_E19229g Kluyveromyces lactis uncharacterized protein XP_454821.1 1713099 D 28985 CDS KLLA0_E19251g 2894682 1715991..1717967 E 1 NC_006041.1 similar to uniprot|Q08989 Saccharomyces cerevisiae YPL277C Hypothetical ORFs; uncharacterized protein 1717967 2894682 KLLA0_E19251g Kluyveromyces lactis uncharacterized protein XP_454822.1 1715991 D 28985 CDS KLLA0_E19273g 2894683 1718449..1719495 E 1 NC_006041.1 similar to uniprot|P53155 Saccharomyces cerevisiae YGL082W and similar to uniprot|Q08930 Saccharomyces cerevisiae YPL191C Hypothetical ORFs; uncharacterized protein 1719495 2894683 KLLA0_E19273g Kluyveromyces lactis uncharacterized protein XP_454823.1 1718449 D 28985 CDS KLLA0_E19295g 2894456 1720040..1721050 E 1 NC_006041.1 some similarities with YGL081w; uncharacterized protein 1721050 2894456 KLLA0_E19295g Kluyveromyces lactis uncharacterized protein XP_454824.1 1720040 D 28985 CDS KLLA0_E19317g 2894457 1721330..1721728 E 1 NC_006041.1 no similarity; uncharacterized protein 1721728 2894457 KLLA0_E19317g Kluyveromyces lactis uncharacterized protein XP_454825.1 1721330 D 28985 CDS KLLA0_E19339g 2894458 complement(1721747..1722775) E 1 NC_006041.1 similar to uniprot|Q08932 Saccharomyces cerevisiae YPL193W RSA1 RiboSome Assembly; uncharacterized protein 1722775 2894458 KLLA0_E19339g Kluyveromyces lactis uncharacterized protein XP_454826.1 1721747 R 28985 CDS KLLA0_E19361g 2894459 1723526..1723900 E 1 NC_006041.1 similar to uniprot|P53157 Saccharomyces cerevisiae YGL080W FMP37; pyruvate transporter MPC1 1723900 2894459 KLLA0_E19361g Kluyveromyces lactis pyruvate transporter MPC1 XP_454827.1 1723526 D 28985 CDS KLLA0_E19383g 2894122 complement(1724099..1725760) E 1 NC_006041.1 similar to uniprot|Q08949 Saccharomyces cerevisiae YPL194W DDC1 DNA damage checkpoint protein part of a PCNA-like complex required for DNA damage response required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates potential Cdc28p substrate; uncharacterized protein 1725760 2894122 KLLA0_E19383g Kluyveromyces lactis uncharacterized protein XP_454828.1 1724099 R 28985 CDS KLLA0_E19405g 2893960 complement(1725950..1728676) E 1 NC_006041.1 similar to uniprot|Q7LIB1 Saccharomyces cerevisiae YPL195W APL5 Delta-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway suppressor of loss of casein kinase 1 function delta-like subunit of the yeast AP-3 adaptin component of the membrane-associated clathrin assembly complex; uncharacterized protein 1728676 2893960 KLLA0_E19405g Kluyveromyces lactis uncharacterized protein XP_454829.1 1725950 R 28985 CDS KLLA0_E19427g 2893961 1728952..1729488 E 1 NC_006041.1 similar to uniprot|Q755A2 Ashbya gossypii AFL077C AFL077Cp and weakly similar to YGL079W uniprot|P53158 Saccharomyces cerevisiae YGL079W Hypothetical ORF; uncharacterized protein 1729488 2893961 KLLA0_E19427g Kluyveromyces lactis uncharacterized protein XP_454830.1 1728952 D 28985 CDS KLLA0_E19449g 2893962 complement(1729566..1730318) E 1 NC_006041.1 similar to uniprot|Q08952 Saccharomyces cerevisiae YPL196W OXR1 Protein of unknown function required for normal levels of resistance to oxidative damage null mutants are sensitive to hydrogen peroxide; uncharacterized protein 1730318 2893962 KLLA0_E19449g Kluyveromyces lactis uncharacterized protein XP_454831.1 1729566 R 28985 CDS KLLA0_E19471g 2893963 complement(1730651..1732372) E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 1732372 2893963 KLLA0_E19471g Kluyveromyces lactis uncharacterized protein XP_454832.1 1730651 R 28985 CDS KLLA0_E19493g 2893964 1732921..1733478 E 1 NC_006041.1 weakly similar to uniprot|P32772 Saccharomyces cerevisiae YDL169C Protein of unknown function, transcript accumulates in response to any combination of stress conditions; uncharacterized protein 1733478 2893964 KLLA0_E19493g Kluyveromyces lactis uncharacterized protein XP_454833.1 1732921 D 28985 CDS KLLA0_E19515g 2893965 complement(1733708..1735426) E 1 NC_006041.1 similar to uniprot|P21304 Saccharomyces cerevisiae YLR196W PWP1; rRNA-processing protein PWP1 1735426 2893965 KLLA0_E19515g Kluyveromyces lactis rRNA-processing protein PWP1 XP_454834.1 1733708 R 28985 CDS KLLA0_E19537g 2894734 1736016..1737359 E 1 NC_006041.1 similar to uniprot|P14743 Saccharomyces cerevisiae YLR195C NMT1 N-myristoyl transferase catalyzes the cotranslational covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction; glycylpeptide N-tetradecanoyltransferase NMT1 1737359 2894734 KLLA0_E19537g Kluyveromyces lactis glycylpeptide N-tetradecanoyltransferase NMT1 XP_454835.1 1736016 D 28985 CDS KLLA0_E19559g 2894735 1737862..1738464 E 1 NC_006041.1 some similarities with uniprot|Q05777 Saccharomyces cerevisiae YLR194C Hypothetical ORF; uncharacterized protein 1738464 2894735 KLLA0_E19559g Kluyveromyces lactis uncharacterized protein XP_454836.1 1737862 D 28985 CDS KLLA0_E19581g 2894736 1738957..1739481 E 1 NC_006041.1 similar to uniprot|Q05776 Saccharomyces cerevisiae YLR193C Hypothetical ORF; uncharacterized protein 1739481 2894736 KLLA0_E19581g Kluyveromyces lactis uncharacterized protein XP_454837.1 1738957 D 28985 CDS KLLA0_E19603g 2894737 complement(1739869..1741914) E 1 NC_006041.1 weakly similar to uniprot|P26370 Saccharomyces cerevisiae YDL170W; uncharacterized protein 1741914 2894737 KLLA0_E19603g Kluyveromyces lactis uncharacterized protein XP_454838.1 1739869 R 28985 CDS KLLA0_E19625g 2894738 1743508..1749933 E 1 NC_006041.1 highly similar to uniprot|Q12680 Saccharomyces cerevisiae YDL171C GLT1 NAD()-dependent glutamate synthase (GOGAT) synthesizes glutamate from glutamine and alpha-ketoglutarate with Gln1p forms the secondary pathway for glutamate biosynthesis from ammonia expression regulated by nitrogen source; glutamate synthase (NADH) 1749933 2894738 KLLA0_E19625g Kluyveromyces lactis glutamate synthase (NADH) XP_454839.1 1743508 D 28985 CDS KLLA0_E19647g 2894758 complement(1750310..1750777) E 1 NC_006041.1 weakly similar to uniprot|Q6Q543 Saccharomyces cerevisiae YDL173W Hypothetical ORF; uncharacterized protein 1750777 2894758 KLLA0_E19647g Kluyveromyces lactis uncharacterized protein XP_454840.1 1750310 R 28985 CDS KLLA0_E19669g 2894757 1751471..1752304 E 1 NC_006041.1 similar to uniprot|Q05775 Saccharomyces cerevisiae YLR192C HCR1 Dual function protein involved in translation initiation as a substoichiometric component of eukaryotic translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA; translation initiation factor eIF3 core subunit j 1752304 2894757 KLLA0_E19669g Kluyveromyces lactis translation initiation factor eIF3 core subunit j XP_454841.1 1751471 D 28985 CDS KLLA0_E19691g 2894285 1752867..1754597 E 1 NC_006041.1 uniprot|Q12627 Kluyveromyces lactis DLD1 D-lactate dehydrogenase mitochondrial precursor; D-lactate dehydrogenase 1754597 2894285 KLLA0_E19691g Kluyveromyces lactis D-lactate dehydrogenase XP_454842.1 1752867 D 28985 CDS KLLA0_E19713g 2894760 1755931..1756362 E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 1756362 2894760 KLLA0_E19713g Kluyveromyces lactis uncharacterized protein XP_454843.1 1755931 D 28985 CDS KLLA0_E19735g 2894761 complement(1756682..1757908) E 1 NC_006041.1 similar to uniprot|P80667 Saccharomyces cerevisiae YLR191W PEX13 Integral peroxisomal membrane receptor; peroxin PEX13 1757908 2894761 KLLA0_E19735g Kluyveromyces lactis peroxin PEX13 XP_454844.1 1756682 R 28985 CDS KLLA0_E19757g 2894759 complement(1758427..1759794) E 1 NC_006041.1 weakly similar to uniprot|Q06324 Saccharomyces cerevisiae YLR190W MMR1 Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p; uncharacterized protein 1759794 2894759 KLLA0_E19757g Kluyveromyces lactis uncharacterized protein XP_454845.1 1758427 R 28985 CDS KLLA0_E19779g 2894722 complement(1760800..1762503) E 1 NC_006041.1 highly similar to uniprot|P00927 Saccharomyces cerevisiae YER086W ILV1 Threonine deaminase catalyzes the first step in isoleucine biosynthesis expression is under general amino acid control ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation; threonine ammonia-lyase ILV1 1762503 2894722 KLLA0_E19779g Kluyveromyces lactis threonine ammonia-lyase ILV1 XP_454846.1 1760800 R 28985 CDS KLLA0_E19801g 2894723 1763061..1764710 E 1 NC_006041.1 similar to uniprot|P39965 Saccharomyces cerevisiae YER087W Hypothetical ORF; uncharacterized protein 1764710 2894723 KLLA0_E19801g Kluyveromyces lactis uncharacterized protein XP_454847.1 1763061 D 28985 CDS KLLA0_E19823g 2894724 complement(1765241..1765507) E 1 NC_006041.1 similar to uniprot|P52871 Saccharomyces cerevisiae YER019C-A SBH2 Ssh1p-Sss1p-Sbh2p complex component involved in protein translocation into the endoplasmic reticulum homologous to Sbh1p; Arf family guanine nucleotide exchange factor SBH1 1765507 2894724 KLLA0_E19823g Kluyveromyces lactis Arf family guanine nucleotide exchange factor SBH1 XP_454848.1 1765241 R 28985 CDS KLLA0_E19845g 2894725 1766853..1768631 E 1 NC_006041.1 similar to uniprot|Q75BN6 Ashbya gossypii ACR235W ACR235Wp and weakly similar to YBL051C uniprot|P34217 Saccharomyces cerevisiae YBL051C PIN4 Protein involved in G2/M phase progression and response to DNA damage interacts with Rad53p contains an RNA recognition motif a nuclear localization signal and several SQ/TQ cluster domains hyperphosphorylated in response to DNA damage; uncharacterized protein 1768631 2894725 KLLA0_E19845g Kluyveromyces lactis uncharacterized protein XP_454849.1 1766853 D 28985 CDS KLLA0_E19867g 2894726 1769223..1769594 E 1 NC_006041.1 no similarity; uncharacterized protein 1769594 2894726 KLLA0_E19867g Kluyveromyces lactis uncharacterized protein XP_454850.1 1769223 D 28985 CDS KLLA0_E19889g 2894727 1770061..1771161 E 1 NC_006041.1 similar to uniprot|Q04894 Saccharomyces cerevisiae YMR318C ADH6 NADPH-dependent cinnamyl alcohol dehydrogenase family member with broad substrate specificity may be involved in fusel alcohol synthesis or in aldehyde tolerance; uncharacterized protein 1771161 2894727 KLLA0_E19889g Kluyveromyces lactis uncharacterized protein XP_454851.1 1770061 D 28985 CDS KLLA0_E19911g 2894708 1771778..1773976 E 1 NC_006041.1 similar to uniprot|Q75BN5 Ashbya gossypii ACR236W ACR236Wp and weakly similar to YBL052C uniprot|P34218 Saccharomyces cerevisiae YBL052C SAS3 Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3 involved in transcriptional silencing homolog of the mammalian MOZ proto-oncogene sas3 gcn5 double mutation confers lethality; histone acetyltransferase 1773976 2894708 KLLA0_E19911g Kluyveromyces lactis histone acetyltransferase XP_454852.1 1771778 D 28985 CDS KLLA0_E19933g 2894709 complement(1774534..1776285) E 1 NC_006041.1 some similarities with uniprot|P40059 Saccharomyces cerevisiae YER088C DOT6 Protein of unknown function involved in telomeric gene silencing and filamentation; uncharacterized protein 1776285 2894709 KLLA0_E19933g Kluyveromyces lactis uncharacterized protein XP_454853.1 1774534 R 28985 CDS KLLA0_E19955g 2894710 1777217..1778563 E 1 NC_006041.1 similar to uniprot|P34220 Saccharomyces cerevisiae YBL055C Hypothetical ORF; 3'-5'-exodeoxyribonuclease 1778563 2894710 KLLA0_E19955g Kluyveromyces lactis 3'-5'-exodeoxyribonuclease XP_454854.1 1777217 D 28985 CDS KLLA0_E19977g 2894711 complement(1779199..1780515) E 1 NC_006041.1 similar to uniprot|P34221 Saccharomyces cerevisiae YBL056W PTC3 Type 2C protein phosphatase dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p) role in DNA checkpoint inactivation; uncharacterized protein 1780515 2894711 KLLA0_E19977g Kluyveromyces lactis uncharacterized protein XP_454855.1 1779199 R 28985 CDS KLLA0_E19999g 2894712 1781349..1782875 E 1 NC_006041.1 similar to uniprot|P00899 Saccharomyces cerevisiae YER090W TRP2 anthranilate synthase Component I; anthranilate synthase TRP2 1782875 2894712 KLLA0_E19999g Kluyveromyces lactis anthranilate synthase TRP2 XP_454856.1 1781349 D 28985 CDS KLLA0_E20021g 2894713 1783264..1783908 E 1 NC_006041.1 similar to uniprot|P34222 Saccharomyces cerevisiae YBL057C PTH2 mitochondrially-localized peptidyl-tRNA hydrolase; aminoacyl-tRNA hydrolase 1783908 2894713 KLLA0_E20021g Kluyveromyces lactis aminoacyl-tRNA hydrolase XP_454857.1 1783264 D 28985 CDS KLLA0_E20043g 2894714 complement(1784051..1785253) E 1 NC_006041.1 similar to uniprot|P34223 Saccharomyces cerevisiae YBL058W SHP1 UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate; protein phosphatase regulator SHP1 1785253 2894714 KLLA0_E20043g Kluyveromyces lactis protein phosphatase regulator SHP1 XP_454858.1 1784051 R 28985 CDS KLLA0_E20065g 2894698 complement(1786006..1788312) E 1 NC_006041.1 highly similar to uniprot|P05694 Saccharomyces cerevisiae YER091C MET6 Cobalamin-independent methionine synthase involved in amino acid biosynthesis also called N5-methyltetrahydrofolate homocysteine methyltransferase or 5-methyltetrahydropteroyltriglutamate homocysteine methyltransferase; 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase 1788312 2894698 KLLA0_E20065g Kluyveromyces lactis 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase XP_454859.1 1786006 R 28985 CDS KLLA0_E20087g 2894699 complement(1788696..1789070) E 1 NC_006041.1 no similarity; uncharacterized protein 1789070 2894699 KLLA0_E20087g Kluyveromyces lactis uncharacterized protein XP_454860.1 1788696 R 28985 CDS KLLA0_E20109g 2894700 1789335..1789688 E 1 NC_006041.1 similar to uniprot|P40060 Saccharomyces cerevisiae YER092W IES5 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; uncharacterized protein 1789688 2894700 KLLA0_E20109g Kluyveromyces lactis uncharacterized protein XP_454861.1 1789335 D 28985 CDS KLLA0_E20131g 2894701 complement(1789708..1793664) E 1 NC_006041.1 similar to uniprot|P40061 Saccharomyces cerevisiae YER093C TSC11 Binding Protein of TOR Protein required for cell viability; TORC2 complex subunit TSC11 1793664 2894701 KLLA0_E20131g Kluyveromyces lactis TORC2 complex subunit TSC11 XP_454862.1 1789708 R 28985 CDS KLLA0_E20153g 2894702 complement(join(1793963..1794258,1794336..1794492)) E 1 NC_006041.1 similar to uniprot|P87275 Saccharomyces cerevisiae YER093C-A Hypothetical ORF; uncharacterized protein 1794492 2894702 KLLA0_E20153g Kluyveromyces lactis uncharacterized protein XP_454863.1 1793963 R 28985 CDS KLLA0_E20175g 2894703 join(1794752..1794785,1794879..1795165) E 1 NC_006041.1 highly similar to uniprot|Q3E7A4 Saccharomyces cerevisiae YBL059ca; uncharacterized protein 1795165 2894703 KLLA0_E20175g Kluyveromyces lactis uncharacterized protein XP_454864.1 1794752 D 28985 CDS KLLA0_E20197g 2894666 complement(1795485..1796102) E 1 NC_006041.1 highly similar to uniprot|P25451 Saccharomyces cerevisiae YER094C PUP3 Beta subunit of the 20S proteasome involved in ubiquitin-dependent catabolism human homolog is subunit C10; proteasome core particle subunit beta 3 1796102 2894666 KLLA0_E20197g Kluyveromyces lactis proteasome core particle subunit beta 3 XP_454865.1 1795485 R 28985 CDS KLLA0_E20219g 2894667 complement(1796579..1798423) E 1 NC_006041.1 weakly similar to uniprot|P34225 Saccharomyces cerevisiae YBL060W Hypothetical ORF; Arf family guanine nucleotide exchange factor YEL1 1798423 2894667 KLLA0_E20219g Kluyveromyces lactis Arf family guanine nucleotide exchange factor YEL1 XP_454866.1 1796579 R 28985 CDS KLLA0_E20241g 2894668 1799331..1800440 E 1 NC_006041.1 uniprot|Q6XCZ0 Kluyveromyces lactis RAD51 Rad51p; recombinase RAD51 1800440 2894668 KLLA0_E20241g Kluyveromyces lactis recombinase RAD51 XP_454867.1 1799331 D 28985 CDS KLLA0_E20263g 2894669 1801106..1803187 E 1 NC_006041.1 similar to uniprot|P34226 Saccharomyces cerevisiae YBL061C SKT5 Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation; uncharacterized protein 1803187 2894669 KLLA0_E20263g Kluyveromyces lactis uncharacterized protein XP_454868.1 1801106 D 28985 CDS KLLA0_E20285g 2894670 1803791..1804540 E 1 NC_006041.1 similar to uniprot|P34227 Saccharomyces cerevisiae YBL064C PRX1 Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity has a role in reduction of hydroperoxides induced during respiratory growth and under conditions of oxidative stress; thioredoxin peroxidase PRX1 1804540 2894670 KLLA0_E20285g Kluyveromyces lactis thioredoxin peroxidase PRX1 XP_454869.1 1803791 D 28985 CDS KLLA0_E20307g 9487299 1806005..1809364 E 1 NC_006041.1 uniprot|P87164 Kluyveromyces lactis SEF1 Suppressor protein SEF1; uncharacterized protein 1809364 9487299 KLLA0_E20307g Kluyveromyces lactis uncharacterized protein XP_002999411.1 1806005 D 28985 CDS KLLA0_E20351g 2894672 1810593..1812686 E 1 NC_006041.1 similar to uniprot|P39967 Saccharomyces cerevisiae YER098W UBP9 Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; ubiquitin-specific protease UBP13 1812686 2894672 KLLA0_E20351g Kluyveromyces lactis ubiquitin-specific protease UBP13 XP_454871.1 1810593 D 28985 CDS KLLA0_E20373g 2894673 complement(1812974..1813948) E 1 NC_006041.1 highly similar to uniprot|P38620 Saccharomyces cerevisiae YER099C PRS2 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase involved in nucleotide histidine and tryptophan biosynthesis one of a five related enzymes which are active as heteromultimeric complexes; uncharacterized protein 1813948 2894673 KLLA0_E20373g Kluyveromyces lactis uncharacterized protein XP_454872.1 1812974 R 28985 CDS KLLA0_E20395g 2894674 1814618..1815373 E 1 NC_006041.1 similar to uniprot|P33296 Saccharomyces cerevisiae YER100W UBC6 Ubiquitin-conjugating enzyme involved in ER-associated protein degradation located at the cytosolic side of the ER membrane tail region contains a transmembrane segment at the C-terminus substrate of the ubiquitin-proteasome pathway; E2 ubiquitin-conjugating protein UBC6 1815373 2894674 KLLA0_E20395g Kluyveromyces lactis E2 ubiquitin-conjugating protein UBC6 XP_454873.1 1814618 D 28985 CDS KLLA0_E20417g 2894675 complement(1815696..1816982) E 1 NC_006041.1 weakly similar to uniprot|P35183 Saccharomyces cerevisiae YBL069W AST1 peripheral membrane protein; uncharacterized protein 1816982 2894675 KLLA0_E20417g Kluyveromyces lactis uncharacterized protein XP_454874.1 1815696 R 28985 CDS KLLA0_E20439g 2894676 complement(1817441..1817689) E 1 NC_006041.1 highly similar to uniprot|Q3E840 Saccharomyces cerevisiae YBL071W-A KTI11 Protein required along with Dph1p Dph2p Jjj3p and Dph5p for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) may act in a complex with Dph1p and Dph2p; uncharacterized protein 1817689 2894676 KLLA0_E20439g Kluyveromyces lactis uncharacterized protein XP_454875.1 1817441 R 28985 CDS KLLA0_E20461g 2894677 1818978..1819583 E 1 NC_006041.1 similar to uniprot|P05754 Saccharomyces cerevisiae YER102W RPS8B protein component of the small (40S) ribosomal subunit; 40S ribosomal protein eS8 1819583 2894677 KLLA0_E20461g Kluyveromyces lactis 40S ribosomal protein eS8 XP_454876.1 1818978 D 28985 CDS KLLA0_E20505g 2894678 1820449..1821522 E 1 NC_006041.1 similar to uniprot|Q74Z30 Ashbya gossypii AGR376W AGR376Wp and weakly similar to YBL074C uniprot|P32357 Saccharomyces cerevisiae YBL074C AAR2 Component of the U5 snRNP required for splicing of U3 precursors originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron; U5 snRNP complex subunit AAR2 1821522 2894678 KLLA0_E20505g Kluyveromyces lactis U5 snRNP complex subunit AAR2 XP_454877.1 1820449 D 28985 CDS KLLA0_E20527g 2894514 1822412..1824364 E 1 NC_006041.1 highly similar to uniprot|P09435 Saccharomyces cerevisiae YBL075C SSA3 heat-inducible cytosolic member of the 70 kDa heat shock protein family; Hsp70 family ATPase SSA3 1824364 2894514 KLLA0_E20527g Kluyveromyces lactis Hsp70 family ATPase SSA3 XP_454878.1 1822412 D 28985 CDS KLLA0_E20549g 2894515 1825036..1828257 E 1 NC_006041.1 highly similar to uniprot|P09436 Saccharomyces cerevisiae YBL076C ILS1 Cytoplasmic isoleucine-tRNA synthetase target of the G1-specific inhibitor reveromycin A; isoleucine--tRNA ligase ILS1 1828257 2894515 KLLA0_E20549g Kluyveromyces lactis isoleucine--tRNA ligase ILS1 XP_454879.1 1825036 D 28985 CDS KLLA0_E20571g 2894516 1828627..1829190 E 1 NC_006041.1 some similarities with uniprot|P40063 Saccharomyces cerevisiae YER104W RTT105 same phenotype as RTT101, 102, 103, 104; Regulator of Ty1 Transposition; uncharacterized protein 1829190 2894516 KLLA0_E20571g Kluyveromyces lactis uncharacterized protein XP_454880.1 1828627 D 28985 CDS KLLA0_E20593g 2894517 1829697..1830071 E 1 NC_006041.1 highly similar to uniprot|P38182 Saccharomyces cerevisiae YBL078C ATG8 Protein required for autophagy; ubiquitin-like protein ATG8 1830071 2894517 KLLA0_E20593g Kluyveromyces lactis ubiquitin-like protein ATG8 XP_454881.1 1829697 D 28985 CDS KLLA0_E20615g 2894518 complement(1830746..1835104) E 1 NC_006041.1 similar to uniprot|P38181 Saccharomyces cerevisiae YBL079W NUP170 Abundant subunit of the nuclear pore complex (NPC), required for proper localization of specific nucleoporins within the NPC, involved in nuclear envelope permeability and in chromosome segregation; uncharacterized protein 1835104 2894518 KLLA0_E20615g Kluyveromyces lactis uncharacterized protein XP_454882.1 1830746 R 28985 CDS KLLA0_E20637g 2894519 1835743..1836678 E 1 NC_006041.1 weakly similar to uniprot|P40065 Saccharomyces cerevisiae YER106W MAM1 Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle; uncharacterized protein 1836678 2894519 KLLA0_E20637g Kluyveromyces lactis uncharacterized protein XP_454883.1 1835743 D 28985 CDS KLLA0_E20659g 2894489 1837058..1838677 E 1 NC_006041.1 similar to uniprot|P33893 Saccharomyces cerevisiae YBL080C PET112 Protein required for mitochondrial translation; glutamyl-tRNA(Gln) amidotransferase subunit PET112 1838677 2894489 KLLA0_E20659g Kluyveromyces lactis glutamyl-tRNA(Gln) amidotransferase subunit PET112 XP_454884.1 1837058 D 28985 CDS KLLA0_E20681g 2894490 complement(1839142..1840266) E 1 NC_006041.1 weakly similar to uniprot|P38180 Saccharomyces cerevisiae YBL081W Hypothetical ORF; uncharacterized protein 1840266 2894490 KLLA0_E20681g Kluyveromyces lactis uncharacterized protein XP_454885.1 1839142 R 28985 CDS KLLA0_E20703g 2894491 complement(1841092..1842207) E 1 NC_006041.1 similar to uniprot|P40066 Saccharomyces cerevisiae YER107C GLE2 Component of the nuclear pore complex required for polyadenylated RNA export but not for protein import homologous to S. pombe Rae1p; RNA export factor GLE2 1842207 2894491 KLLA0_E20703g Kluyveromyces lactis RNA export factor GLE2 XP_454886.1 1841092 R 28985 CDS KLLA0_E20725g 2894492 complement(1842953..1845673) E 1 NC_006041.1 some similarities with uniprot|P40068 Saccharomyces cerevisiae YER109c PHD5 required for diploid filamentous growth singleton; uncharacterized protein 1845673 2894492 KLLA0_E20725g Kluyveromyces lactis uncharacterized protein XP_454887.1 1842953 R 28985 CDS KLLA0_E20747g 2894493 complement(1846948..1848336) E 1 NC_006041.1 similar to uniprot|P38179 Saccharomyces cerevisiae YBL082C RHK1 Dolichol-P-Man dependent alpha(1-3) mannosyltransferase involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins; dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase 1848336 2894493 KLLA0_E20747g Kluyveromyces lactis dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase XP_454888.1 1846948 R 28985 CDS KLLA0_E20769g 2894494 complement(1848703..1852044) E 1 NC_006041.1 highly similar to uniprot|P40069 Saccharomyces cerevisiae YER110C KAP123 Karyopherin beta mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4 localizes to the nuclear pore nucleus and cytoplasm exhibits genetic interactions with RAI1; uncharacterized protein 1852044 2894494 KLLA0_E20769g Kluyveromyces lactis uncharacterized protein XP_454889.1 1848703 R 28985 CDS KLLA0_E20791g 2894495 complement(1852522..1855323) E 1 NC_006041.1 some similarities with uniprot|P25302 Saccharomyces cerevisiae YER111C SWI4 Involved in cell cycle dependent gene expression transcription factor; SBF complex DNA-binding subunit SWI4 1855323 2894495 KLLA0_E20791g Kluyveromyces lactis SBF complex DNA-binding subunit SWI4 XP_454890.1 1852522 R 28985 CDS KLLA0_E20813g 2894649 1856387..1856938 E 1 NC_006041.1 uniprot|Q96UG3 Kluyveromyces lactis KLLA0E20889g putative hypothetical protein putative LSM4; U6 snRNA complex subunit LSM4 1856938 2894649 KLLA0_E20813g Kluyveromyces lactis U6 snRNA complex subunit LSM4 XP_454891.1 1856387 D 28985 CDS KLLA0_E20835g 2894650 complement(1857426..1859456) E 1 NC_006041.1 similar to uniprot|P40071 Saccharomyces cerevisiae YER113C Hypothetical ORF; uncharacterized protein 1859456 2894650 KLLA0_E20835g Kluyveromyces lactis uncharacterized protein XP_454892.1 1857426 R 28985 CDS KLLA0_E20857g 2894651 1860517..1862649 E 1 NC_006041.1 similar to uniprot|Q751K0 Ashbya gossypii AGL294W AGL294Wp and some similarites with YBL084C uniprot|P38042 Saccharomyces cerevisiae YBL084C CDC27 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition; anaphase promoting complex subunit CDC27 1862649 2894651 KLLA0_E20857g Kluyveromyces lactis anaphase promoting complex subunit CDC27 XP_454893.1 1860517 D 28985 CDS KLLA0_E20879g 2894652 complement(1862894..1865941) E 1 NC_006041.1 similar to uniprot|P39969 Saccharomyces cerevisiae YER114C BOI2 Protein implicated in polar growth functionally redundant with Boi1p interacts with bud-emergence protein Bem1p contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; uncharacterized protein 1865941 2894652 KLLA0_E20879g Kluyveromyces lactis uncharacterized protein XP_454894.1 1862894 R 28985 CDS KLLA0_E20901g 2894653 complement(1866407..1867567) E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 1867567 2894653 KLLA0_E20901g Kluyveromyces lactis uncharacterized protein XP_454895.1 1866407 R 28985 CDS KLLA0_E20923g 2894654 1868214..1869524 E 1 NC_006041.1 similar to uniprot|P38177 Saccharomyces cerevisiae YBL086C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; uncharacterized protein 1869524 2894654 KLLA0_E20923g Kluyveromyces lactis uncharacterized protein XP_454896.1 1868214 D 28985 CDS KLLA0_E20945g 2894642 1870154..1871740 E 1 NC_006041.1 weakly similar to uniprot|P42833 Saccharomyces cerevisiae YNL318C, HXT14 protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studie; uncharacterized protein 1871740 2894642 KLLA0_E20945g Kluyveromyces lactis uncharacterized protein XP_454897.1 1870154 D 28985 CDS KLLA0_E20967g 2894643 1872227..1876192 E 1 NC_006041.1 similar to uniprot|Q92271 Saccharomyces cerevisiae YOL138C Hypothetical ORF; uncharacterized protein 1876192 2894643 KLLA0_E20967g Kluyveromyces lactis uncharacterized protein XP_454898.1 1872227 D 28985 CDS KLLA0_E20989g 2894644 complement(1876222..1877082) E 1 NC_006041.1 similar to uniprot|P42840 Saccharomyces cerevisiae YNL320W Hypothetical ORF; uncharacterized protein 1877082 2894644 KLLA0_E20989g Kluyveromyces lactis uncharacterized protein XP_454899.1 1876222 R 28985 CDS KLLA0_E21011g 2894645 1877678..1878310 E 1 NC_006041.1 similar to uniprot|P07260 Saccharomyces cerevisiae YOL139C CDC33 Cytoplasmic mRNA cap binding protein the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with the translation initiation factor eIF4G (Tif4631p or Tif4632p); translation initiation factor eIF4E 1878310 2894645 KLLA0_E21011g Kluyveromyces lactis translation initiation factor eIF4E XP_454900.1 1877678 D 28985 CDS KLLA0_E21033g 2894646 complement(1878737..1881682) E 1 NC_006041.1 similar to uniprot|P42839 Saccharomyces cerevisiae YNL321W Protein of unknown function potential Cdc28p substrate; uncharacterized protein 1881682 2894646 KLLA0_E21033g Kluyveromyces lactis uncharacterized protein XP_454901.1 1878737 R 28985 CDS KLLA0_E21055g 2894647 1882430..1883215 E 1 NC_006041.1 weakly similar to uniprot|P17260 Saccharomyces cerevisiae YNL322C KRE1 Cell wall glycoprotein involved in beta-glucan assembly serves as a K1 killer toxin membrane receptor; uncharacterized protein 1883215 2894647 KLLA0_E21055g Kluyveromyces lactis uncharacterized protein XP_454902.1 1882430 D 28985 CDS KLLA0_E21077g 2894291 complement(1883452..1884723) E 1 NC_006041.1 highly similar to uniprot|P18544 Saccharomyces cerevisiae YOL140W ARG8 Acetylornithine aminotransferase catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine; acetylornithine transaminase 1884723 2894291 KLLA0_E21077g Kluyveromyces lactis acetylornithine transaminase XP_454903.1 1883452 R 28985 CDS KLLA0_E21099g 2894648 complement(join(1885338..1885976,1886092..1886127)) E 1 NC_006041.1 similar to uniprot|Q06999 Saccharomyces cerevisiae YDR367W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; uncharacterized protein 1886127 2894648 KLLA0_E21099g Kluyveromyces lactis uncharacterized protein XP_454904.1 1885338 R 28985 CDS KLLA0_E21121g 2894636 1886452..1888032 E 1 NC_006041.1 similar to uniprot|Q12196 YOR119C Saccharomyces cerevisiae RIO1 Essential protein that plays a role in cell cycle progression; protein kinase RIO1 1888032 2894636 KLLA0_E21121g Kluyveromyces lactis protein kinase RIO1 XP_454905.1 1886452 D 28985 CDS KLLA0_E21143g 2894637 complement(1888085..1889803) E 1 NC_006041.1 similar to uniprot|Q12108 YOR118W Saccharomyces cerevisiae Hypothetical ORF; uncharacterized protein 1889803 2894637 KLLA0_E21143g Kluyveromyces lactis uncharacterized protein XP_454906.1 1888085 R 28985 CDS KLLA0_E21165g 2894638 1890314..1892197 E 1 NC_006041.1 similar to uniprot|Q06344 YDR365C Saccharomyces cerevisiae ESF1 Nucleolar protein involved in pre-rRNA processing; pre-rRNA-processing protein ESF1 1892197 2894638 KLLA0_E21165g Kluyveromyces lactis pre-rRNA-processing protein ESF1 XP_454907.1 1890314 D 28985 CDS KLLA0_E21187g 2894639 1892524..1893813 E 1 NC_006041.1 similar to uniprot|P40968 Saccharomyces cerevisiae YDR364C CDC40 Pre-mRNA splicing factor important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression required for DNA synthesis during mitosis and meiosis has WD repeats; uncharacterized protein 1893813 2894639 KLLA0_E21187g Kluyveromyces lactis uncharacterized protein XP_454908.1 1892524 D 28985 CDS KLLA0_E21209g 2894640 complement(1893904..1895202) E 1 NC_006041.1 highly similar to uniprot|P33297 Saccharomyces cerevisiae YOR117W RPT5 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates recruited to the GAL1-10 promoter region upon induction of transcription; proteasome regulatory particle base subunit RPT5 1895202 2894640 KLLA0_E21209g Kluyveromyces lactis proteasome regulatory particle base subunit RPT5 XP_454909.1 1893904 R 28985 CDS KLLA0_E21231g 2894630 complement(1895618..1895812) E 1 NC_006041.1 similar to uniprot|O94742 Saccharomyces cerevisiae YDR363W-A Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; proteasome regulatory particle lid subunit SEM1 1895812 2894630 KLLA0_E21231g Kluyveromyces lactis proteasome regulatory particle lid subunit SEM1 XP_454911.1 1895618 R 28985 CDS KLLA0_E21253g 2894631 1896457..1900830 E 1 NC_006041.1 highly similar to uniprot|P04051 Saccharomyces cerevisiae YOR116C; DNA-directed RNA polymerase III core subunit RPO31 1900830 2894631 KLLA0_E21253g Kluyveromyces lactis DNA-directed RNA polymerase III core subunit RPO31 XP_454912.1 1896457 D 28985 CDS KLLA0_E21275g 2894632 complement(1900927..1902105) E 1 NC_006041.1 some similarities with uniprot|Q06340 YDR363W Saccharomyces cerevisiae ESC2 Protein involved in mating-type locus silencing interacts with Sir2p; uncharacterized protein 1902105 2894632 KLLA0_E21275g Kluyveromyces lactis uncharacterized protein XP_454913.1 1900927 R 28985 CDS KLLA0_E21297g 2894633 complement(1902420..1903919) E 1 NC_006041.1 similar to uniprot|P38821 YHR113W Saccharomyces cerevisiae Hypothetical ORF; aspartyl aminopeptidase 1903919 2894633 KLLA0_E21297g Kluyveromyces lactis aspartyl aminopeptidase XP_454914.1 1902420 R 28985 CDS KLLA0_E21319g 2894634 1904841..1905983 E 1 NC_006041.1 highly similar to uniprot|P38716 Saccharomyces cerevisiae YHR112C Hypothetical ORF; uncharacterized protein 1905983 2894634 KLLA0_E21319g Kluyveromyces lactis uncharacterized protein XP_454915.1 1904841 D 28985 CDS KLLA0_E21341g 2894635 1906322..1908136 E 1 NC_006041.1 weakly similar to uniprot|Q06339 YDR362C Saccharomyces cerevisiae TFC6 one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); transcription factor TFIIIC subunit TFC6 1908136 2894635 KLLA0_E21341g Kluyveromyces lactis transcription factor TFIIIC subunit TFC6 XP_454916.1 1906322 D 28985 CDS KLLA0_E21363g 2894623 complement(1908181..1909515) E 1 NC_006041.1 similar to uniprot|P38820 YHR111W Saccharomyces cerevisiae UBA4 Protein that activates Urm1p before its conjugation to proteins (urmylation); uncharacterized protein 1909515 2894623 KLLA0_E21363g Kluyveromyces lactis uncharacterized protein XP_454917.1 1908181 R 28985 CDS KLLA0_E21385g 2894624 complement(1909837..1910478) E 1 NC_006041.1 similar to uniprot|P38819 Saccharomyces cerevisiae YHR110W; uncharacterized protein 1910478 2894624 KLLA0_E21385g Kluyveromyces lactis uncharacterized protein XP_454918.1 1909837 R 28985 CDS KLLA0_E21407g 2894625 complement(1910837..1912348) E 1 NC_006041.1 weakly similar to uniprot|P38818 YHR109W Saccharomyces cerevisiae CTM1 Cytochrome c lysine methyltransferase; cytochrome c lysine N-methyltransferase 1912348 2894625 KLLA0_E21407g Kluyveromyces lactis cytochrome c lysine N-methyltransferase XP_454919.1 1910837 R 28985 CDS KLLA0_E21429g 2894626 1912931..1913749 E 1 NC_006041.1 similar to uniprot|Q06338 YDR361C Saccharomyces cerevisiae BCP1 Essential protein involved in nuclear export of Mss4p; protein-transporting protein BCP1 1913749 2894626 KLLA0_E21429g Kluyveromyces lactis protein-transporting protein BCP1 XP_454920.1 1912931 D 28985 CDS KLLA0_E21451g 2894627 1914249..1917266 E 1 NC_006041.1 similar to uniprot|Q06337 YDR359C Saccharomyces cerevisiae VID21 Component of the NuA4 histone acetyltransferase complex; uncharacterized protein 1917266 2894627 KLLA0_E21451g Kluyveromyces lactis uncharacterized protein XP_454921.1 1914249 D 28985 CDS KLLA0_E21473g 2894628 complement(1917382..1919127) E 1 NC_006041.1 some similarities with uniprot|P38817 YHR108W Saccharomyces cerevisiae GGA2 Golgi-localized protein with homology to gamma-adaptin; uncharacterized protein 1919127 2894628 KLLA0_E21473g Kluyveromyces lactis uncharacterized protein XP_454922.1 1917382 R 28985 CDS KLLA0_E21495g 2894629 1919564..1919938 E 1 NC_006041.1 similar to uniprot|Q06333 YDR357C Saccharomyces cerevisiae Protein of unknown function; uncharacterized protein 1919938 2894629 KLLA0_E21495g Kluyveromyces lactis uncharacterized protein XP_454923.1 1919564 D 28985 CDS KLLA0_E21517g 2894617 complement(1920040..1922616) E 1 NC_006041.1 similar to uniprot|Q756L3 Ashbya gossypii AER241W AER241Wp and weakly similar to YDR356W uniprot|P32380 Saccharomyces cerevisiae YDR356W SPC110 Inner plaque spindle pole body (SPB) component ortholog of human kendrin involved in connecting nuclear microtubules to SPB interacts with Tub4p-complex and calmodulin phosphorylated by Mps1p in cell cycle-dependent manner; uncharacterized protein 1922616 2894617 KLLA0_E21517g Kluyveromyces lactis uncharacterized protein XP_454924.1 1920040 R 28985 CDS KLLA0_E21539g 2894618 complement(1923103..1924305) E 1 NC_006041.1 similar to uniprot|P38347 YBR271W Saccharomyces cerevisiae Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; S-adenosylmethionine-dependent methyltransferase 1924305 2894618 KLLA0_E21539g Kluyveromyces lactis S-adenosylmethionine-dependent methyltransferase XP_454925.1 1923103 R 28985 CDS KLLA0_E21561g 2894619 complement(1924493..1925581) E 1 NC_006041.1 similar to uniprot|P07285 YDR354W Saccharomyces cerevisiae TRP4 anthranilate phosphoribosyl transferase; anthranilate phosphoribosyltransferase 1925581 2894619 KLLA0_E21561g Kluyveromyces lactis anthranilate phosphoribosyltransferase XP_454926.1 1924493 R 28985 CDS KLLA0_E21583g 2894620 1926061..1927245 E 1 NC_006041.1 similar to uniprot|P32468 Saccharomyces cerevisiae YHR107C CDC12 Component of the septin ring of the mother-bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM; septin CDC12 1927245 2894620 KLLA0_E21583g Kluyveromyces lactis septin CDC12 XP_454927.1 1926061 D 28985 CDS KLLA0_E21605g 2894621 complement(1927687..1928736) E 1 NC_006041.1 highly similar to uniprot|P29509 YDR353W Saccharomyces cerevisiae TRR1 Thioredoxin reductase; uncharacterized protein 1928736 2894621 KLLA0_E21605g Kluyveromyces lactis uncharacterized protein XP_454928.1 1927687 R 28985 CDS KLLA0_E21627g 2894271 complement(1929294..1930283) E 1 NC_006041.1 highly similar to uniprot|P38715 Saccharomyces cerevisiae YHR104W GRE3 Aldose reductase involved in methylglyoxal d-xylose and arabinose metabolism stress induced (osmotic ionic oxidative heat shock starvation and heavy metals) regulated by the HOG pathway; trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+)) 1930283 2894271 KLLA0_E21627g Kluyveromyces lactis trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+)) XP_454929.1 1929294 R 28985 CDS KLLA0_E21649g 2894622 complement(1931058..1932017) E 1 NC_006041.1 similar to uniprot|Q06328 YDR352w Saccharomyces cerevisiae Hypothetical ORF; uncharacterized protein 1932017 2894622 KLLA0_E21649g Kluyveromyces lactis uncharacterized protein XP_454930.1 1931058 R 28985 CDS KLLA0_E21671g 2894611 complement(1932604..1935069) E 1 NC_006041.1 similar to uniprot|P38814 YHR103W Saccharomyces cerevisiae SBE Protein involved in the transport of cell wall components from the Golgi to the cell surface; uncharacterized protein 1935069 2894611 KLLA0_E21671g Kluyveromyces lactis uncharacterized protein XP_454931.1 1932604 R 28985 CDS KLLA0_E21693g 2894612 complement(1936438..1939488) E 1 NC_006041.1 weakly similar to uniprot|P38692 Saccharomyces cerevisiae YHR102W KIC1 Protein kinase of the PAK/Ste20 kinase family required for cell integrity possibly through regulating 1 6-beta-glucan levels in the wall physically interacts with Cdc31p (centrin) which is a component of the spindle pole body; uncharacterized protein 1939488 2894612 KLLA0_E21693g Kluyveromyces lactis uncharacterized protein XP_454932.1 1936438 R 28985 CDS KLLA0_E21715g 2894614 1940144..1942279 E 1 NC_006041.1 weakly similar to uniprot|P50273 YDR350C Saccharomyces cerevisiae CM10 Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase; uncharacterized protein 1942279 2894614 KLLA0_E21715g Kluyveromyces lactis uncharacterized protein XP_454934.1 1940144 D 28985 CDS KLLA0_E21737g 9487375 join(1942411..1942424,1942793..1943651) E 1 NC_006041.1 weakly similar to uniprot|P38813 Saccharomyces cerevisiae YHR101C BIG1 Integral membrane protein of the endoplasmic reticulum required for normal content of cell wall beta-1 6-glucan; uncharacterized protein 1943651 9487375 KLLA0_E21737g Kluyveromyces lactis uncharacterized protein XP_002999412.1 1942411 D 28985 CDS KLLA0_E21759g 2894616 1943933..1944760 E 1 NC_006041.1 similar to uniprot|P32854 Saccharomyces cerevisiae YOR036W PEP12 Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole controls entry of biosynthetic endocytic and retrograde traffic into the prevacuolar compartment syntaxin; SNAP receptor PEP12 1944760 2894616 KLLA0_E21759g Kluyveromyces lactis SNAP receptor PEP12 XP_454936.1 1943933 D 28985 CDS KLLA0_E21781g 2894604 complement(1944865..1945866) E 1 NC_006041.1 similar to uniprot|Q05583 YDR267C Saccharomyces cerevisiae CIA1 Protein required for cell viability; iron-sulfur cluster assembly protein CIA1 1945866 2894604 KLLA0_E21781g Kluyveromyces lactis iron-sulfur cluster assembly protein CIA1 XP_454937.1 1944865 R 28985 CDS KLLA0_E21803g 2894605 1946190..1947263 E 1 NC_006041.1 similar to uniprot|P38909 Saccharomyces cerevisiae YOR037W CYC2 Mitochondrial protein required for normal abundance of mitochondrial cytochrome c (Cyc1p) and for mitochondrial osmotic stability may be involved in regulating the activity of cytochrome c heme lyase (Cyc3p) potential Cdc28p substrate; oxidoreductase 1947263 2894605 KLLA0_E21803g Kluyveromyces lactis oxidoreductase XP_454938.1 1946190 D 28985 CDS KLLA0_E21825g 2894606 1947496..1948632 E 1 NC_006041.1 similar to uniprot|P04803 YDR268W Saccharomyces cerevisiae MSW1 Mitochondrial tryptophanyl-tRNA synthetase; tryptophan--tRNA ligase MSW1 1948632 2894606 KLLA0_E21825g Kluyveromyces lactis tryptophan--tRNA ligase MSW1 XP_454939.1 1947496 D 28985 CDS KLLA0_E21847g 2894607 complement(1948687..1951230) E 1 NC_006041.1 similar to uniprot|P32480 Saccharomyces cerevisiae YOR038C HIR2 Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A H2B H3 and H4 genes recruits Swi-Snf complexes to histone gene promoters promotes heterochromatic gene silencing with Asf1p; uncharacterized protein 1951230 2894607 KLLA0_E21847g Kluyveromyces lactis uncharacterized protein XP_454940.1 1948687 R 28985 CDS KLLA0_E21869g 2894608 1951763..1952545 E 1 NC_006041.1 similar to uniprot|P38930 Saccharomyces cerevisiae YOR039W CKB2 protein kinase CK2 beta' subunit; casein kinase 2 regulatory subunit CKB2 1952545 2894608 KLLA0_E21869g Kluyveromyces lactis casein kinase 2 regulatory subunit CKB2 XP_454941.1 1951763 D 28985 CDS KLLA0_E21891g 2894609 1954118..1955761 E 1 NC_006041.1 similar to uniprot|P40215 Saccharomyces cerevisiae YMR145C NDE1 Mitochondrial external NADH dehydrogenase; uncharacterized protein 1955761 2894609 KLLA0_E21891g Kluyveromyces lactis uncharacterized protein XP_454942.1 1954118 D 28985 CDS KLLA0_E21913g 2894610 1958004..1959410 E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 1959410 2894610 KLLA0_E21913g Kluyveromyces lactis uncharacterized protein XP_454943.1 1958004 D 28985 CDS KLLA0_E21935g 2894435 1959770..1961083 E 1 NC_006041.1 highly similar to uniprot|Q07478 Saccharomyces cerevisiae YDL084W SUB2 Suppresses the cold-sensitive snRNP biogenesis brr1-1 mutation RNA helicase; ATP-dependent RNA helicase SUB2 1961083 2894435 KLLA0_E21935g Kluyveromyces lactis ATP-dependent RNA helicase SUB2 XP_454944.1 1959770 D 28985 CDS KLLA0_E21957g 2894436 complement(1961626..1962786) E 1 NC_006041.1 weakly similar to uniprot|P40214 Saccharomyces cerevisiae YMR144W Hypothetical ORF; uncharacterized protein 1962786 2894436 KLLA0_E21957g Kluyveromyces lactis uncharacterized protein XP_454945.1 1961626 R 28985 CDS KLLA0_E21979g 2894437 complement(join(1963506..1963913,1964493..1964516)) E 1 NC_006041.1 highly similar to uniprot|P40213 Saccharomyces cerevisiae YMR143w RPS16A or uniprot|P40213 Saccharomyces cerevisiae YDL083c RPS16B; 40S ribosomal protein uS9 1964516 2894437 KLLA0_E21979g Kluyveromyces lactis 40S ribosomal protein uS9 XP_454946.1 1963506 R 28985 CDS KLLA0_E22001g 2894438 join(1965666..1965669,1966262..1966857) E 1 NC_006041.1 highly similar to uniprot|Q12690 Saccharomyces cerevisiae YDL082w RPL13A ribosomal protein or uniprot|P40212 Saccharomyces cerevisiae YMR142c RPL13B; 60S ribosomal protein eL13 1966857 2894438 KLLA0_E22001g Kluyveromyces lactis 60S ribosomal protein eL13 XP_454947.1 1965666 D 28985 CDS KLLA0_E22023g 2894439 complement(1967315..1967635) E 1 NC_006041.1 highly similar to uniprot|P05318 Saccharomyces cerevisiae YDL081C RPP1A Ribosomal protein P1 alpha a component of the ribosomal stalk which is involved in the interaction between translational elongation factors and the ribosome accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component; ribosomal protein P1 1967635 2894439 KLLA0_E22023g Kluyveromyces lactis ribosomal protein P1 XP_454948.1 1967315 R 28985 CDS KLLA0_E22045g 2894440 complement(1968293..1969744) E 1 NC_006041.1 similar to uniprot|P40210 Saccharomyces cerevisiae YMR140W SIP5 Sip5p facilitates the interaction between the Glc7p phosphatase and the Snf1p kinase; uncharacterized protein 1969744 2894440 KLLA0_E22045g Kluyveromyces lactis uncharacterized protein XP_454949.1 1968293 R 28985 CDS KLLA0_E22089g 2894430 complement(1970992..1972404) E 1 NC_006041.1 weakly similar to uniprot|P18544 Saccharomyces cerevisiae YOL140W ARG8 Acetylornithine aminotransferase catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine; uncharacterized protein 1972404 2894430 KLLA0_E22089g Kluyveromyces lactis uncharacterized protein XP_454951.1 1970992 R 28985 CDS KLLA0_E22111g 2894431 1973522..1974187 E 1 NC_006041.1 similar to uniprot|P32626 Saccharomyces cerevisiae YEL038W UTR4 Protein of unknown function found in both the cytoplasm and nucleus; uncharacterized protein 1974187 2894431 KLLA0_E22111g Kluyveromyces lactis uncharacterized protein XP_454952.1 1973522 D 28985 CDS KLLA0_E22133g 2894432 complement(1974635..1975786) E 1 NC_006041.1 similar to uniprot|P32628 Saccharomyces cerevisiae YEL037C RAD23; uncharacterized protein 1975786 2894432 KLLA0_E22133g Kluyveromyces lactis uncharacterized protein XP_454953.1 1974635 R 28985 CDS KLLA0_E22155g 2894433 complement(1976362..1977714) E 1 NC_006041.1 similar to uniprot|P32629 Saccharomyces cerevisiae YEL036C ANP1 Mannan 8 Protein of the endoplasmic reticulum with a role in retention of glycosyltransferases in the Golgi also involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol subunit of mannosyltransferase complex; uncharacterized protein 1977714 2894433 KLLA0_E22155g Kluyveromyces lactis uncharacterized protein XP_454954.1 1976362 R 28985 CDS KLLA0_E22177g 2894434 1978388..1978777 E 1 NC_006041.1 no similarity; uncharacterized protein 1978777 2894434 KLLA0_E22177g Kluyveromyces lactis uncharacterized protein XP_454955.1 1978388 D 28985 CDS KLLA0_E22199g 2894422 1979344..1979817 E 1 NC_006041.1 highly similar to uniprot|P19211 Saccharomyces cerevisiae ANB1 Translation initiation factor eIF-5A, and to YEL034W uniprot|P23301 Saccharomyces cerevisiae YEL034W HYP2 Translation initiation factor eIF-5A; uncharacterized protein 1979817 2894422 KLLA0_E22199g Kluyveromyces lactis uncharacterized protein XP_454956.1 1979344 D 28985 CDS KLLA0_E22243g 2894424 1981275..1984070 E 1 NC_006041.1 similar to uniprot|P24279 Saccharomyces cerevisiae YEL032W MCM3 Protein involved in DNA replication component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; MCM DNA helicase complex subunit MCM3 1984070 2894424 KLLA0_E22243g Kluyveromyces lactis MCM DNA helicase complex subunit MCM3 XP_454957.1 1981275 D 28985 CDS KLLA0_E22265g 2894425 1984522..1988142 E 1 NC_006041.1 highly similar to uniprot|P39986 Saccharomyces cerevisiae YEL031W SPF1 Sensitivity to a killer toxin (SMK toxin) produced by Pichia Farinosa P-type ATPase; ion-transporting P-type ATPase SPF1 1988142 2894425 KLLA0_E22265g Kluyveromyces lactis ion-transporting P-type ATPase SPF1 XP_454958.1 1984522 D 28985 CDS KLLA0_E22287g 2894426 complement(1988282..1989994) E 1 NC_006041.1 similar to uniprot|P47112 Saccharomyces cerevisiae YJR046W TAH11 (DNA replication); uncharacterized protein 1989994 2894426 KLLA0_E22287g Kluyveromyces lactis uncharacterized protein XP_454959.1 1988282 R 28985 CDS KLLA0_E22309g 2894427 1990670..1992595 E 1 NC_006041.1 highly similar to uniprot|P12398 Saccharomyces cerevisiae YJR045C; Hsp70 family ATPase ECM10 1992595 2894427 KLLA0_E22309g Kluyveromyces lactis Hsp70 family ATPase ECM10 XP_454960.1 1990670 D 28985 CDS KLLA0_E22331g 2894415 1993214..1993642 E 1 NC_006041.1 similar to uniprot|P47111 Saccharomyces cerevisiae YJR044C VPS55 Vacuolar Protein Sorting YJR044c; uncharacterized protein 1993642 2894415 KLLA0_E22331g Kluyveromyces lactis uncharacterized protein XP_454962.1 1993214 D 28985 CDS KLLA0_E22375g 2894417 complement(1994296..1995234) E 1 NC_006041.1 similar to uniprot|P39988 Saccharomyces cerevisiae YEL029C; uncharacterized protein 1995234 2894417 KLLA0_E22375g Kluyveromyces lactis uncharacterized protein XP_454963.1 1994296 R 28985 CDS KLLA0_E22397g 2894418 1996893..1997771 E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 1997771 2894418 KLLA0_E22397g Kluyveromyces lactis uncharacterized protein XP_454964.1 1996893 D 28985 CDS KLLA0_E22419g 2894419 1998187..1999356 E 1 NC_006041.1 weakly similar to uniprot|P47110 Saccharomyces cerevisiae YJR043C POL32 Third subunit of DNA polymerase delta involved in chromosomal DNA replication required for error-prone DNA synthesis in the presence of DNA damage and processivity interacts with Pol31p PCNA (Pol30p) and Pol1p; DNA polymerase delta subunit POL32 1999356 2894419 KLLA0_E22419g Kluyveromyces lactis DNA polymerase delta subunit POL32 XP_454965.1 1998187 D 28985 CDS KLLA0_E22441g 2894420 2000055..2000537 E 1 NC_006041.1 similar to uniprot|P25515 Saccharomyces cerevisiae YEL027W CUP5 Proteolipid subunit of the vacuolar H()-ATPase V0 sector required for vacuolar acidification and important for copper and iron metal ion homeostasis; H(+)-transporting V0 sector ATPase subunit c 2000537 2894420 KLLA0_E22441g Kluyveromyces lactis H(+)-transporting V0 sector ATPase subunit c XP_454966.1 2000055 D 28985 CDS KLLA0_E22463g 2894421 complement(2001004..2003178) E 1 NC_006041.1 similar to uniprot|P46673 Saccharomyces cerevisiae YJR042W NUP85 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) required for assembly of the subcomplex and also for formation of the nucleocytoplasmic Gsp1p concentration gradient that plays a role in nuclear trafficking; uncharacterized protein 2003178 2894421 KLLA0_E22463g Kluyveromyces lactis uncharacterized protein XP_454967.1 2001004 R 28985 CDS KLLA0_E22485g 2894409 2003803..2007237 E 1 NC_006041.1 similar to uniprot|Q757T4 Ashbya gossypii AEL072W AEL072Wp and weakly similar to YJR041C uniprot|P47108 Saccharomyces cerevisiae YJR041C URB2 Nucleolar protein required for normal metabolism of the rRNA primary transcript proposed to be involved in ribosome biogenesis; uncharacterized protein 2007237 2894409 KLLA0_E22485g Kluyveromyces lactis uncharacterized protein XP_454968.1 2003803 D 28985 CDS KLLA0_E22507g 2894410 complement(2007287..2009557) E 1 NC_006041.1 similar to uniprot|P37020 Saccharomyces cerevisiae YJR040W GEF1 Chloride channel localized to late- or post-Golgi vesicles involved in iron metabolism highly homologous to voltage-gated chloride channels in vertebrates; uncharacterized protein 2009557 2894410 KLLA0_E22507g Kluyveromyces lactis uncharacterized protein XP_454969.1 2007287 R 28985 CDS KLLA0_E22529g 2894411 2010162..2010542 E 1 NC_006041.1 highly similar to uniprot|P39990 Saccharomyces cerevisiae YEL026W SNU13 RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein; RNA binding protein SNU13 2010542 2894411 KLLA0_E22529g Kluyveromyces lactis RNA binding protein SNU13 XP_454971.1 2010162 D 28985 CDS KLLA0_E22551g 2894413 2011000..2013420 E 1 NC_006041.1 similar to uniprot|P40985 Saccharomyces cerevisiae YJR036C HUL4 Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability; uncharacterized protein 2013420 2894413 KLLA0_E22551g Kluyveromyces lactis uncharacterized protein XP_454972.1 2011000 D 28985 CDS KLLA0_E22573g 2894414 2014172..2014813 E 1 NC_006041.1 highly similar to uniprot|P08067 Saccharomyces cerevisiae YEL024W RIP1 oxidizes ubiquinol at center P in the protonmotive Q cycle mechanism transferring one electron to cytochrome c1 and generating a low-potential ubisemiquinone anion which reduces the low-potential cytochrome b-566 heme group Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; ubiquinol--cytochrome-c reductase catalytic subunit RIP1 2014813 2894414 KLLA0_E22573g Kluyveromyces lactis ubiquinol--cytochrome-c reductase catalytic subunit RIP1 XP_454973.1 2014172 D 28985 CDS KLLA0_E22595g 2894402 complement(2015938..2017968) E 1 NC_006041.1 similar to uniprot|P39992 Saccharomyces cerevisiae YEL023C Hypothetical ORF; uncharacterized protein 2017968 2894402 KLLA0_E22595g Kluyveromyces lactis uncharacterized protein XP_454974.1 2015938 R 28985 CDS KLLA0_E22617g 2894403 complement(2018248..2021349) E 1 NC_006041.1 similar to uniprot|P40352 Saccharomyces cerevisiae YJR035W RAD26 Protein involved in transcription-coupled repair nucleotide excision repair of UV-induced DNA lesions homolog of human CSB protein; DNA-dependent ATPase RAD26 2021349 2894403 KLLA0_E22617g Kluyveromyces lactis DNA-dependent ATPase RAD26 XP_454975.1 2018248 R 28985 CDS KLLA0_E22661g 2894405 complement(2022425..2022751) E 1 NC_006041.1 highly similar to uniprot|Q02772 Saccharomyces cerevisiae YJR034W PET191 Protein required for assembly of cytochrome c oxidase; uncharacterized protein 2022751 2894405 KLLA0_E22661g Kluyveromyces lactis uncharacterized protein XP_454976.1 2022425 R 28985 CDS KLLA0_E22683g 2894406 2023109..2027200 E 1 NC_006041.1 weakly similar to uniprot|P47104 Saccharomyces cerevisiae YJR033C RAV1 Subunit of the RAVE complex (Rav1p Rav2p Skp1p) which promotes assembly of the V-ATPase holoenzyme required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins potential Cdc28p substrate; uncharacterized protein 2027200 2894406 KLLA0_E22683g Kluyveromyces lactis uncharacterized protein XP_454977.1 2023109 D 28985 CDS KLLA0_E22705g 2894407 complement(2027229..2028398) E 1 NC_006041.1 similar to uniprot|P47103 Saccharomyces cerevisiae YJR032W CPR7 Peptidyl-prolyl cis-trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues binds to Hsp82p and contributes to chaperone activity; peptidylprolyl isomerase CPR7 2028398 2894407 KLLA0_E22705g Kluyveromyces lactis peptidylprolyl isomerase CPR7 XP_454978.1 2027229 R 28985 CDS KLLA0_E22727g 2894408 2028791..2032954 E 1 NC_006041.1 similar to uniprot|P39993 Saccharomyces cerevisiae YEL022W; uncharacterized protein 2032954 2894408 KLLA0_E22727g Kluyveromyces lactis uncharacterized protein XP_454979.1 2028791 D 28985 CDS KLLA0_E22749g 2894394 complement(2033077..2034387) E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 2034387 2894394 KLLA0_E22749g Kluyveromyces lactis uncharacterized protein XP_454980.1 2033077 R 28985 CDS KLLA0_E22771g 2894282 2034995..2035798 E 1 NC_006041.1 highly similar to uniprot|P03962 Saccharomyces cerevisiae YEL021W URA3 orotidine-5'-phosphate decarboxylase; orotidine-5'-phosphate decarboxylase 2035798 2894282 KLLA0_E22771g Kluyveromyces lactis orotidine-5'-phosphate decarboxylase XP_454981.1 2034995 D 28985 CDS KLLA0_E22793g 2894395 2036117..2036380 E 1 NC_006041.1 highly similar to uniprot|O74700 Saccharomyces cerevisiae YEL020W-A TIM9 Mitochondrial intermembrane space protein mediating import and insertion of polytopic inner membrane proteins; protein transporter TIM9 2036380 2894395 KLLA0_E22793g Kluyveromyces lactis protein transporter TIM9 XP_454982.1 2036117 D 28985 CDS KLLA0_E22859g 9487308 complement(2037327..2038079) E 1 NC_006041.1 similar to uniprot|Q754L8 Ashbya gossypii AFR054W AFR054Wp and weakly similar to YNL148C uniprot|P53904 Saccharomyces cerevisiae YNL148C ALF1 alpha-tubulin foldin protein implicated in folding of alpha tubulin cofactor B; uncharacterized protein 2038079 9487308 KLLA0_E22859g Kluyveromyces lactis uncharacterized protein XP_002999413.1 2037327 R 28985 CDS KLLA0_E22881g 2894398 join(2038281..2038292,2038423..2038743) E 1 NC_006041.1 highly similar to uniprot|P53905 Saccharomyces cerevisiae YNL147W LSM7 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay; Sm-like protein LSM7 2038743 2894398 KLLA0_E22881g Kluyveromyces lactis Sm-like protein LSM7 XP_454984.1 2038281 D 28985 CDS KLLA0_E22903g 2894399 2039283..2039936 E 1 NC_006041.1 highly similar to uniprot|P18562 Saccharomyces cerevisiae YHR128W FUR1 Uracil phosphoribosyltransferase synthesizes UMP from uracil involved in the pyrimidine salvage pathway; uracil phosphoribosyltransferase 2039936 2894399 KLLA0_E22903g Kluyveromyces lactis uracil phosphoribosyltransferase XP_454985.1 2039283 D 28985 CDS KLLA0_E22925g 2894400 complement(2040279..2041421) E 1 NC_006041.1 similar to uniprot|P38696 Saccharomyces cerevisiae YHR129C ARP1 Actin-related protein of the dynactin complex required for spindle orientation and nuclear migration putative ortholog of mammalian centractin; actin-related protein 1 2041421 2894400 KLLA0_E22925g Kluyveromyces lactis actin-related protein 1 XP_454986.1 2040279 R 28985 CDS KLLA0_E22947g 2894388 complement(2041663..2043489) E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 2043489 2894388 KLLA0_E22947g Kluyveromyces lactis uncharacterized protein XP_454987.1 2041663 R 28985 CDS KLLA0_E22969g 2894389 complement(2044323..2046779) E 1 NC_006041.1 similar to uniprot|P38835 Saccharomyces cerevisiae YHR131C Hypothetical ORF; uncharacterized protein 2046779 2894389 KLLA0_E22969g Kluyveromyces lactis uncharacterized protein XP_454988.1 2044323 R 28985 CDS KLLA0_E22991g 2894390 complement(2047913..2049145) E 1 NC_006041.1 similar to uniprot|P38130 Saccharomyces cerevisiae YBR205W KTR3 Putative alpha-1 2-mannosyltransferase involved in O- and N-linked protein glycosylation member of the KRE2/MNT1 mannosyltransferase family; mannosyltransferase KTR3 2049145 2894390 KLLA0_E22991g Kluyveromyces lactis mannosyltransferase KTR3 XP_454989.1 2047913 R 28985 CDS KLLA0_E23013g 2894391 complement(2049719..2050726) E 1 NC_006041.1 some similarities with uniprot|P53324 Saccharomyces cerevisiae YGR263C; steryl deacetylase 2050726 2894391 KLLA0_E23013g Kluyveromyces lactis steryl deacetylase XP_454990.1 2049719 R 28985 CDS KLLA0_E23035g 2894392 2051146..2052123 E 1 NC_006041.1 weakly similar to uniprot|P38139 Saccharomyces cerevisiae YBR204C Hypothetical ORF; triacylglycerol lipase 2052123 2894392 KLLA0_E23035g Kluyveromyces lactis triacylglycerol lipase XP_454991.1 2051146 D 28985 CDS KLLA0_E23057g 2894393 complement(2052418..2053941) E 1 NC_006041.1 highly similar to uniprot|P54115 Saccharomyces cerevisiae YPL061W ALD6 Cytosolic aldehyde dehydrogenase that is activated by Mg2 and utilizes NADP as the preferred coenzyme; aldehyde dehydrogenase (NADP(+)) ALD6 2053941 2894393 KLLA0_E23057g Kluyveromyces lactis aldehyde dehydrogenase (NADP(+)) ALD6 XP_454992.1 2052418 R 28985 CDS KLLA0_E23079g 2894382 complement(2056949..2059129) E 1 NC_006041.1 weakly similar to uniprot|P38308 Saccharomyces cerevisiae YBR203W COS111 Protein required for wild-type resistance to the antifungal drug ciclopirox olamine not related to the COS family of subtelomerically-encoded proteins; uncharacterized protein 2059129 2894382 KLLA0_E23079g Kluyveromyces lactis uncharacterized protein XP_454993.1 2056949 R 28985 CDS KLLA0_E23101g 2894383 complement(2059506..2060948) E 1 NC_006041.1 similar to uniprot|Q02776 Saccharomyces cerevisiae YPL063W TIM50 Protein of the inner mitochondrial membrane required for import of mitochondrial matrix proteins; protein translocase subunit TIM50 2060948 2894383 KLLA0_E23101g Kluyveromyces lactis protein translocase subunit TIM50 XP_454994.1 2059506 R 28985 CDS KLLA0_E23123g 2894384 complement(2061320..2062060) E 1 NC_006041.1 similar to uniprot|Q02767 Saccharomyces cerevisiae YPL065W VPS28 Component of the ESCRT-I complex which is involved in ubiquitin-dependent sorting of proteins into the endosome involved in transport of precursors for soluble vacuolar hydrolases from the late endosome to the vacuole; ESCRT-I subunit protein VPS28 2062060 2894384 KLLA0_E23123g Kluyveromyces lactis ESCRT-I subunit protein VPS28 XP_454995.1 2061320 R 28985 CDS KLLA0_E23145g 2894385 complement(2062230..2063543) E 1 NC_006041.1 similar to uniprot|Q12194 Saccharomyces cerevisiae YPL066W Hypothetical ORF; uncharacterized protein 2063543 2894385 KLLA0_E23145g Kluyveromyces lactis uncharacterized protein XP_454996.1 2062230 R 28985 CDS KLLA0_E23167g 2894386 2064516..2065583 E 1 NC_006041.1 similar to uniprot|P53909 Saccharomyces cerevisiae YNL141W AAH1 Adenine deaminase (adenine aminohydrolase) involved in purine salvage and nitrogen catabolism; adenine deaminase 2065583 2894386 KLLA0_E23167g Kluyveromyces lactis adenine deaminase XP_454997.1 2064516 D 28985 CDS KLLA0_E23189g 2894387 complement(2065845..2068325) E 1 NC_006041.1 similar to uniprot|P38132 Saccharomyces cerevisiae YBR202W CDC47 Component of the hexameric MCM complex which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase; DNA replication licensing factor MCM7 2068325 2894387 KLLA0_E23189g Kluyveromyces lactis DNA replication licensing factor MCM7 XP_454998.1 2065845 R 28985 CDS KLLA0_E23211g 9487458 2069647..2069919 E 1 NC_006041.1 weakly similar to uniprot|Q2V2Q3 Saccharomyces cerevisiae YBR201C-A; uncharacterized protein 2069919 9487458 KLLA0_E23211g Kluyveromyces lactis uncharacterized protein XP_002999414.1 2069647 D 28985 CDS KLLA0_E23233g 2894376 2070261..2070881 E 1 NC_006041.1 weakly similar to uniprot|Q6Q586 Saccharomyces cerevisiae YPL067C Hypothetical ORF; uncharacterized protein 2070881 2894376 KLLA0_E23233g Kluyveromyces lactis uncharacterized protein XP_455000.1 2070261 D 28985 CDS KLLA0_E23255g 2894377 2071111..2072031 E 1 NC_006041.1 weakly similar to uniprot|Q02749 Saccharomyces cerevisiae YPL068C; uncharacterized protein 2072031 2894377 KLLA0_E23255g Kluyveromyces lactis uncharacterized protein XP_455001.1 2071111 D 28985 CDS KLLA0_E23277g 2894378 complement(2072151..2072720) E 1 NC_006041.1 weakly similar to uniprot|P38307 Saccharomyces cerevisiae YBR201W DER1 Endoplasmic reticulum membrane protein required for the protein degradation process associated with the ER involved in the retrograde transport of misfolded or unassembled proteins; derlin 2072720 2894378 KLLA0_E23277g Kluyveromyces lactis derlin XP_455002.1 2072151 R 28985 CDS KLLA0_E23299g 2894379 2073218..2074165 E 1 NC_006041.1 similar to uniprot|Q12051 Saccharomyces cerevisiae YPL069C BTS1 Geranylgeranyl diphosphate synthase increases the intracellular pool of geranylgeranyl diphosphate suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic; farnesyltranstransferase 2074165 2894379 KLLA0_E23299g Kluyveromyces lactis farnesyltranstransferase XP_455003.1 2073218 D 28985 CDS KLLA0_E23321g 2894380 complement(2074221..2075762) E 1 NC_006041.1 weakly similar to uniprot|Q02866 Saccharomyces cerevisiae YPL070W MUK1 Protein of unknown function localized to the cytoplasm computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation; guanine nucleotide exchange factor MUK1 2075762 2894380 KLLA0_E23321g Kluyveromyces lactis guanine nucleotide exchange factor MUK1 XP_455004.1 2074221 R 28985 CDS KLLA0_E23343g 2894381 2076232..2076762 E 1 NC_006041.1 similar to uniprot|Q02864 Saccharomyces cerevisiae YPL071C Hypothetical ORF; uncharacterized protein 2076762 2894381 KLLA0_E23343g Kluyveromyces lactis uncharacterized protein XP_455005.1 2076232 D 28985 CDS KLLA0_E23365g 9487326 complement(join(2077042..2078760,2078979..2078987)) E 1 NC_006041.1 similar to uniprot|P29366 Saccharomyces cerevisiae YBR200W BEM1 Protein containing SH3-domains involved in establishing cell polarity and morphogenesis functions as a scaffold protein for complexes that include Cdc24p Ste5p Ste20p and Rsr1p; phosphatidylinositol-3-phosphate-binding protein BEM1 2078987 9487326 KLLA0_E23365g Kluyveromyces lactis phosphatidylinositol-3-phosphate-binding protein BEM1 XP_002999415.1 2077042 R 28985 CDS KLLA0_E23387g 2894370 complement(2079405..2081753) E 1 NC_006041.1 some similarities with uniprot|Q02863 Saccharomyces cerevisiae YPL072W UBP16 Putative ubiquitin-specific protease; uncharacterized protein 2081753 2894370 KLLA0_E23387g Kluyveromyces lactis uncharacterized protein XP_455007.1 2079405 R 28985 CDS KLLA0_E23409g 2894371 complement(2082115..2084106) E 1 NC_006041.1 similar to uniprot|P40328 Saccharomyces cerevisiae YPL074W YTA6 Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family localized to the cortex of mother cells but not to daughter cells; uncharacterized protein 2084106 2894371 KLLA0_E23409g Kluyveromyces lactis uncharacterized protein XP_455008.1 2082115 R 28985 CDS KLLA0_E23431g 2894372 complement(2084504..2086807) E 1 NC_006041.1 uniprot|Q9C4B2 Kluyveromyces lactis KLLA0E23507g KlGCR1; transcription regulator GCR1 2086807 2894372 KLLA0_E23431g Kluyveromyces lactis transcription regulator GCR1 XP_455009.1 2084504 R 28985 CDS KLLA0_E23453g 2894373 2088516..2090996 E 1 NC_006041.1 similar to uniprot|P38129 Saccharomyces cerevisiae YBR198C TAF5 Subunit (90 kDa) of TFIID and SAGA complexes involved in RNA polymerase II transcription initiation and in chromatin modification; chromatin modification protein 2090996 2894373 KLLA0_E23453g Kluyveromyces lactis chromatin modification protein XP_455010.1 2088516 D 28985 CDS KLLA0_E23475g 2894374 complement(2091184..2092002) E 1 NC_006041.1 similar to uniprot|P46961 Saccharomyces cerevisiae YPL076W GPI2 Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors homologous to the human PIG-C protein; phosphatidylinositol N-acetylglucosaminyltransferase 2092002 2894374 KLLA0_E23475g Kluyveromyces lactis phosphatidylinositol N-acetylglucosaminyltransferase XP_455011.1 2091184 R 28985 CDS KLLA0_E23497g 2894362 2092311..2092706 E 1 NC_006041.1 some similarities with uniprot|Q02831 Saccharomyces cerevisiae YPL077C; uncharacterized protein 2092706 2894362 KLLA0_E23497g Kluyveromyces lactis uncharacterized protein XP_455012.1 2092311 D 28985 CDS KLLA0_E23519g 2894287 2093243..2094910 E 1 NC_006041.1 highly similar to uniprot|P12709 Saccharomyces cerevisiae YBR196C PGI1 Glycolytic enzyme phosphoglucose isomerase catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate required for cell cycle progression and completion of the gluconeogenic events of sporulation; glucose-6-phosphate isomerase 2094910 2894287 KLLA0_E23519g Kluyveromyces lactis glucose-6-phosphate isomerase XP_455013.1 2093243 D 28985 CDS KLLA0_E23541g 2894363 2095246..2096499 E 1 NC_006041.1 similar to uniprot|P13712 Saccharomyces cerevisiae YBR195C MSI1 Subunit of chromatin assembly factor I (CAF-I) regulates the RAS/cAMP pathway via sequestration of Npr1p kinase localizes to the nucleus and cytoplasm homologous to human retinoblastoma binding proteins RbAp48 and RbAp46; uncharacterized protein 2096499 2894363 KLLA0_E23541g Kluyveromyces lactis uncharacterized protein XP_455014.1 2095246 D 28985 CDS KLLA0_E23563g 2894294 2097204..2097917 E 1 NC_006041.1 uniprot|O13349 Kluyveromyces lactis ATP4 ATP synthase subunit 4 mitochondrial precursor; F1F0 ATP synthase subunit 4 2097917 2894294 KLLA0_E23563g Kluyveromyces lactis F1F0 ATP synthase subunit 4 XP_455015.1 2097204 D 28985 CDS KLLA0_E23585g 9487467 complement(join(2098486..2098784,2098843..2098849)) E 1 NC_006041.1 weakly similar to uniprot|P38305 Saccharomyces cerevisiae YBR194W SOY1 Synthetic with Old Yellow Enzyme; uncharacterized protein 2098849 9487467 KLLA0_E23585g Kluyveromyces lactis uncharacterized protein XP_002999416.1 2098486 R 28985 CDS KLLA0_E23607g 2894365 2099005..2099715 E 1 NC_006041.1 similar to uniprot|P38304 Saccharomyces cerevisiae YBR193C MED8 Member of RNA Polymerase II transcriptional regulation mediator Stoichiometric member of mediator complex; uncharacterized protein 2099715 2894365 KLLA0_E23607g Kluyveromyces lactis uncharacterized protein XP_455017.1 2099005 D 28985 CDS KLLA0_E23629g 2894366 complement(2099965..2101071) E 1 NC_006041.1 highly similar to uniprot|P38127 Saccharomyces cerevisiae YBR192W RIM2 Protein of the mitochondrial carrier (MCF) family that is required for respiration Probable carrier protein mitochondrial; uncharacterized protein 2101071 2894366 KLLA0_E23629g Kluyveromyces lactis uncharacterized protein XP_455018.1 2099965 R 28985 CDS KLLA0_E23651g 2894367 complement(join(2101642..2102113,2102656..2102666)) E 1 NC_006041.1 highly similar to uniprot|Q02753 Saccharomyces cerevisiae YBR191W; 60S ribosomal protein eL21 2102666 2894367 KLLA0_E23651g Kluyveromyces lactis 60S ribosomal protein eL21 XP_455019.1 2101642 R 28985 CDS KLLA0_E23673g 2894356 complement(join(2103729..2104288,2104879..2104885)) E 1 NC_006041.1 highly similar to uniprot|O13516 Saccharomyces cerevisiae YPL081W RPS9A and to uniprot|P05755 Saccharomyces cerevisiae YBR189W RPS9B Proteins component of the small (40S) ribosomal subunit; 40S ribosomal protein uS4 2104885 2894356 KLLA0_E23673g Kluyveromyces lactis 40S ribosomal protein uS4 XP_455021.1 2103729 R 28985 CDS KLLA0_E23695g 2894357 complement(2105401..2106582) E 1 NC_006041.1 highly similar to uniprot|Q12122 Saccharomyces cerevisiae YDL131W LYS21 and to uniprot|P48570 Saccharomyces cerevisiae YDL182W LYS20 homocitrate synthase; uncharacterized protein 2106582 2894357 KLLA0_E23695g Kluyveromyces lactis uncharacterized protein XP_455022.1 2105401 R 28985 CDS KLLA0_E23717g 2894358 2108059..2113680 E 1 NC_006041.1 similar to uniprot|P32333 Saccharomyces cerevisiae YPL082C MOT1 Essential abundant protein involved in regulation of transcription removes Spt15p (TBP) from DNA via its C-terminal ATPase activity forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; DNA-binding ATPase 2113680 2894358 KLLA0_E23717g Kluyveromyces lactis DNA-binding ATPase XP_455023.1 2108059 D 28985 CDS KLLA0_E23739g 9487281 2113963..2114244 E 1 NC_006041.1 no similarity; uncharacterized protein 2114244 9487281 KLLA0_E23739g Kluyveromyces lactis uncharacterized protein XP_002999417.1 2113963 D 28985 CDS KLLA0_E23761g 2894359 complement(2114375..2115202) E 1 NC_006041.1 similar to uniprot|P38301 Saccharomyces cerevisiae YBR187W Hypothetical ORF; uncharacterized protein 2115202 2894359 KLLA0_E23761g Kluyveromyces lactis uncharacterized protein XP_455024.1 2114375 R 28985 CDS KLLA0_E23783g 9487492 complement(join(2115721..2115885,2115988..2117484)) E 1 NC_006041.1 weakly similar to uniprot|P38126 Saccharomyces cerevisiae YBR186W PCH2 Nucleolar component of the pachytene checkpoint which prevents chromosome segregation when recombination and chromosome synapsis are defective also represses meiotic interhomolog recombination in the rDNA; uncharacterized protein 2117484 9487492 KLLA0_E23783g Kluyveromyces lactis uncharacterized protein XP_002999418.1 2115721 R 28985 CDS KLLA0_E23805g 9487324 complement(2118234..2118512) E 1 NC_006041.1 no similarity; uncharacterized protein 2118512 9487324 KLLA0_E23805g Kluyveromyces lactis uncharacterized protein XP_002999419.1 2118234 R 28985 CDS KLLA0_E23849g 2894349 2119396..2120718 E 1 NC_006041.1 similar to uniprot|Q02825 Saccharomyces cerevisiae YPL083C SEN54 Subunit of the tRNA splicing endonuclease which is composed of Sen2p Sen15p Sen34p and Sen54p; tRNA splicing endonuclease subunit SEN54 2120718 2894349 KLLA0_E23849g Kluyveromyces lactis tRNA splicing endonuclease subunit SEN54 XP_455026.1 2119396 D 28985 CDS KLLA0_E23871g 2894350 complement(2120757..2123198) E 1 NC_006041.1 similar to uniprot|P48582 Saccharomyces cerevisiae YPL084W BRO1 Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes; uncharacterized protein 2123198 2894350 KLLA0_E23871g Kluyveromyces lactis uncharacterized protein XP_455027.1 2120757 R 28985 CDS KLLA0_E23893g 2894351 2123599..2124411 E 1 NC_006041.1 similar to uniprot|P38300 Saccharomyces cerevisiae YBR185C MBA1 Protein involved in assembly of mitochondrial respiratory complexes may act as a receptor for proteins destined for export from the mitochondrial matrix to the inner membrane; uncharacterized protein 2124411 2894351 KLLA0_E23893g Kluyveromyces lactis uncharacterized protein XP_455028.1 2123599 D 28985 CDS KLLA0_E23915g 2894352 complement(2124622..2130870) E 1 NC_006041.1 weakly similar to uniprot|P48415 Saccharomyces cerevisiae YPL085W SEC16 COPII vesicle coat protein required for ER transport vesicle budding and autophagosome formation Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes interacts with Sec23p Sec24p and Sec31p; uncharacterized protein 2130870 2894352 KLLA0_E23915g Kluyveromyces lactis uncharacterized protein XP_455029.1 2124622 R 28985 CDS KLLA0_E23937g 2894353 2131460..2133145 E 1 NC_006041.1 highly similar to uniprot|Q02908 Saccharomyces cerevisiae YPL086C ELP3 Histone acetyltransferase subunit of the Elongator complex which is a component of the RNA polymerase II holoenzyme activity is directed specifically towards histones H3 and H4 disruption confers resistance to K. lactis zymotoxin; Elongator subunit ELP3 2133145 2894353 KLLA0_E23937g Kluyveromyces lactis Elongator subunit ELP3 XP_455030.1 2131460 D 28985 CDS KLLA0_E23959g 2894354 complement(2133281..2134462) E 1 NC_006041.1 similar to uniprot|P37303 Saccharomyces cerevisiae YEL046C GLY1 Threonine aldolase catalyzes the cleavage of L-allo-threonine and L-threonine to glycine involved in glycine biosynthesis; uncharacterized protein 2134462 2894354 KLLA0_E23959g Kluyveromyces lactis uncharacterized protein XP_455031.1 2133281 R 28985 CDS KLLA0_E23981g 2894355 complement(2134891..2135856) E 1 NC_006041.1 similar to uniprot|P38298 Saccharomyces cerevisiae YBR183W YPC1 Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity catalyzes both breakdown and synthesis of phytoceramide overexpression confers fumonisin B1 resistance; alkaline dihydroceramidase 2135856 2894355 KLLA0_E23981g Kluyveromyces lactis alkaline dihydroceramidase XP_455032.1 2134891 R 28985 CDS KLLA0_E24003g 2894343 complement(2136583..2137425) E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 2137425 2894343 KLLA0_E24003g Kluyveromyces lactis uncharacterized protein XP_455033.1 2136583 R 28985 CDS KLLA0_E24025g 2894344 2138785..2140983 E 1 NC_006041.1 some similarities with uniprot|P38128 Saccharomyces cerevisiae YBR182C SMP1 Transcription factor of the MADS (Mcm1p Agamous Deficiens SRF) box family closely related to RLM1 Probable DNA-binding transcription factor Homolog to SRF/SL-2; uncharacterized protein 2140983 2894344 KLLA0_E24025g Kluyveromyces lactis uncharacterized protein XP_455034.1 2138785 D 28985 CDS KLLA0_E24047g 2894345 join(2142144..2142149,2142712..2143416) E 1 NC_006041.1 highly similar to uniprot|P02365 Saccharomyces cerevisiae YPL090C RPS6A and to uniprot|P02365 Saccharomyces cerevisiae YBR181C RPS6B Proteins component of the small (40S) ribosomal subunit; 40S ribosomal protein eS6 2143416 2894345 KLLA0_E24047g Kluyveromyces lactis 40S ribosomal protein eS6 XP_455035.1 2142144 D 28985 CDS KLLA0_E24069g 2894346 complement(2143697..2145151) E 1 NC_006041.1 highly similar to uniprot|P41921 Saccharomyces cerevisiae YPL091W GLR1 Cytosolic and mitochondrial glutathione oxidoreductase converts oxidized glutathione to reduced glutathione; glutathione-disulfide reductase GLR1 2145151 2894346 KLLA0_E24069g Kluyveromyces lactis glutathione-disulfide reductase GLR1 XP_455036.1 2143697 R 28985 CDS KLLA0_E24091g 2894347 complement(2145749..2147089) E 1 NC_006041.1 similar to uniprot|Q2VQ77 Saccharomyces cerevisiae YPL092W SSU1 Plasma membrane sulfite pump; uncharacterized protein 2147089 2894347 KLLA0_E24091g Kluyveromyces lactis uncharacterized protein XP_455037.1 2145749 R 28985 CDS KLLA0_E24113g 2894348 complement(2148115..2149842) E 1 NC_006041.1 similar to uniprot|P38125 Saccharomyces cerevisiae YBR180W DTR1 Multidrug resistance dityrosine transporter of the major facilitator superfamily essential for spore wall synthesis facilitates the translocation of bisformyl dityrosine through the prospore membrane; uncharacterized protein 2149842 2894348 KLLA0_E24113g Kluyveromyces lactis uncharacterized protein XP_455038.1 2148115 R 28985 CDS KLLA0_E24135g 2894337 complement(2150759..2152690) E 1 NC_006041.1 highly similar to uniprot|Q02892 Saccharomyces cerevisiae YPL093W NOG1 Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis member of the ODN family of nucleolar G-proteins; uncharacterized protein 2152690 2894337 KLLA0_E24135g Kluyveromyces lactis uncharacterized protein XP_455039.1 2150759 R 28985 CDS KLLA0_E24157g 2894338 2153311..2154051 E 1 NC_006041.1 similar to uniprot|P21825 Saccharomyces cerevisiae YPL094C; Sec63 complex subunit SEC62 2154051 2894338 KLLA0_E24157g Kluyveromyces lactis Sec63 complex subunit SEC62 XP_455040.1 2153311 D 28985 CDS KLLA0_E24179g 2894339 2154452..2156929 E 1 NC_006041.1 similar to uniprot|P38297 Saccharomyces cerevisiae YBR179C FZO1 Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome contains N-terminal GTPase domain; mitofusin 2156929 2894339 KLLA0_E24179g Kluyveromyces lactis mitofusin XP_455041.1 2154452 D 28985 CDS KLLA0_E24201g 2894340 2157376..2158725 E 1 NC_006041.1 similar to uniprot|P38295 Saccharomyces cerevisiae YBR177C EHT1 Possible serine hydrolase and similar to uniprot|Q02891 Saccharomyces cerevisiae YPL095C; medium-chain fatty acid ethyl ester synthase/esterase 2158725 2894340 KLLA0_E24201g Kluyveromyces lactis medium-chain fatty acid ethyl ester synthase/esterase XP_455042.1 2157376 D 28985 CDS KLLA0_E24223g 2894341 complement(2158824..2159885) E 1 NC_006041.1 similar to uniprot|Q02890 Saccharomyces cerevisiae YPL096W PNG1 de-N-glycosylation enzyme peptide:N-glycanase; peptide-N4-(N-acetyl-beta- glucosaminyl)asparagine amidase 2159885 2894341 KLLA0_E24223g Kluyveromyces lactis peptide-N4-(N-acetyl-beta- glucosaminyl)asparagine amidase XP_455043.1 2158824 R 28985 CDS KLLA0_E24245g 9487309 2160073..2160354 E 1 NC_006041.1 no similarity; uncharacterized protein 2160354 9487309 KLLA0_E24245g Kluyveromyces lactis uncharacterized protein XP_002999420.1 2160073 D 28985 CDS KLLA0_E24267g 2894342 complement(2160623..2161984) E 1 NC_006041.1 similar to uniprot|P48527 Saccharomyces cerevisiae YPL097W; tyrosine--tRNA ligase MSY1 2161984 2894342 KLLA0_E24267g Kluyveromyces lactis tyrosine--tRNA ligase MSY1 XP_455044.1 2160623 R 28985 CDS KLLA0_E24289g 2894330 2162312..2162674 E 1 NC_006041.1 similar to uniprot|Q02889 Saccharomyces cerevisiae YPL098C Hypothetical ORF; uncharacterized protein 2162674 2894330 KLLA0_E24289g Kluyveromyces lactis uncharacterized protein XP_455045.1 2162312 D 28985 CDS KLLA0_E24311g 2894331 2162999..2163475 E 1 NC_006041.1 similar to uniprot|Q02888 Saccharomyces cerevisiae YPL099C FMP14 The authentic non-tagged protein was localized to the mitochondria; uncharacterized protein 2163475 2894331 KLLA0_E24311g Kluyveromyces lactis uncharacterized protein XP_455046.1 2162999 D 28985 CDS KLLA0_E24333g 2894332 complement(2163651..2164829) E 1 NC_006041.1 similar to uniprot|Q02887 Saccharomyces cerevisiae YPL100W ATG21 Phosphatidylinositol 3 5-bisphosphate-binding protein required for maturation of pro-aminopeptidase I predicted to fold as a seven-bladed beta-propeller displays punctate cytoplasmic localization; uncharacterized protein 2164829 2894332 KLLA0_E24333g Kluyveromyces lactis uncharacterized protein XP_455047.1 2163651 R 28985 CDS KLLA0_E24355g 2894333 complement(2165178..2166614) E 1 NC_006041.1 similar to uniprot|Q02884 Saccharomyces cerevisiae YPL101W ELP4 Elongator protein part of the HAP subcomplex of Elongator which is a six-subunit component of the RNA polymerase II holoenzyme required for Elongator structural integrity and histone acetyltransferase activity; Elongator subunit ELP4 2166614 2894333 KLLA0_E24355g Kluyveromyces lactis Elongator subunit ELP4 XP_455048.1 2165178 R 28985 CDS KLLA0_E24377g 2894334 2167004..2168338 E 1 NC_006041.1 similar to uniprot|Q02883 Saccharomyces cerevisiae YPL103C; N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D 2168338 2894334 KLLA0_E24377g Kluyveromyces lactis N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D XP_455049.1 2167004 D 28985 CDS KLLA0_E24399g 2894335 complement(2168378..2169334) E 1 NC_006041.1 similar to uniprot|P38122 Saccharomyces cerevisiae YBR176W ECM31 Ketopantoate hydroxymethyltransferase required for pantothenic acid biosynthesis converts 2-oxoisovalerate into 2-dehydropantoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 2169334 2894335 KLLA0_E24399g Kluyveromyces lactis 3-methyl-2-oxobutanoate hydroxymethyltransferase XP_455050.1 2168378 R 28985 CDS KLLA0_E24421g 2894336 2171139..2172245 E 1 NC_006041.1 similar to gnl|GLV|CAGL0K04015g Candida glabrata CAGL0K04015g and weakly similar to YGR031W uniprot|P53219 Saccharomyces cerevisiae YGR031W Hypothetical ORF; uncharacterized protein 2172245 2894336 KLLA0_E24421g Kluyveromyces lactis uncharacterized protein XP_455051.1 2171139 D 28985 CDS KLLA0_E24443g 2894324 2172817..2173449 E 1 NC_006041.1 no similarity; uncharacterized protein 2173449 2894324 KLLA0_E24443g Kluyveromyces lactis uncharacterized protein XP_455052.1 2172817 D 28985 CDS KLLA0_E24465g 2894325 complement(2173560..2175497) E 1 NC_006041.1 similar to uniprot|P15179 Saccharomyces cerevisiae YPL104W Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene; aspartate--tRNA ligase MSD1 2175497 2894325 KLLA0_E24465g Kluyveromyces lactis aspartate--tRNA ligase MSD1 XP_455053.1 2173560 R 28985 CDS KLLA0_E24487g 2894326 complement(2175775..2176758) E 1 NC_006041.1 similar to uniprot|P38123 Saccharomyces cerevisiae YBR175W SWD3 Subunit of the COMPASS complex which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; uncharacterized protein 2176758 2894326 KLLA0_E24487g Kluyveromyces lactis uncharacterized protein XP_455054.1 2175775 R 28985 CDS KLLA0_E24509g 2894327 2177223..2177669 E 1 NC_006041.1 highly similar to uniprot|P38293 Saccharomyces cerevisiae YBR173C UMP1 Short-lived chaperone required for correct maturation of the 20S proteasome degraded by proteasome upon completion of its assembly involved in ubiquitin-mediated proteolysis mutant defective in degradation of short-lived proteins; uncharacterized protein 2177669 2894327 KLLA0_E24509g Kluyveromyces lactis uncharacterized protein XP_455055.1 2177223 D 28985 CDS KLLA0_E24531g 2894328 2178343..2180724 E 1 NC_006041.1 weakly similar to uniprot|P32909 Saccharomyces cerevisiae YBR172C SMY2 partial suppressor of myo2-66 Kinesin-related protein suppressing myosin defects (MYO2) and to uniprot|Q02875 YPL105c; uncharacterized protein 2180724 2894328 KLLA0_E24531g Kluyveromyces lactis uncharacterized protein XP_455056.1 2178343 D 28985 CDS KLLA0_E24553g 2894329 complement(2180838..2181446) E 1 NC_006041.1 similar to uniprot|P33754 Saccharomyces cerevisiae YBR171W SEC66 Non-essential subunit of Sec63 complex (Sec63p Sec62p Sec66p and Sec72p) with Sec61 complex Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; Sec63 complex subunit SEC66 2181446 2894329 KLLA0_E24553g Kluyveromyces lactis Sec63 complex subunit SEC66 XP_455057.1 2180838 R 28985 CDS KLLA0_E24575g 2894317 2181790..2183580 E 1 NC_006041.1 similar to uniprot|P33755 Saccharomyces cerevisiae YBR170C NPL4 Endoplasmic reticulum and nuclear membrane protein forms a complex with Cdc48p and Ufd1p that recognizes ubiquitinated proteins in the endoplasmic reticulum and delivers them to the proteasome for degradation; nuclear protein localization protein 4 2183580 2894317 KLLA0_E24575g Kluyveromyces lactis nuclear protein localization protein 4 XP_455058.1 2181790 D 28985 CDS KLLA0_E24597g 2894318 2183993..2186077 E 1 NC_006041.1 highly similar to uniprot|P32589 Saccharomyces cerevisiae YPL106C SSE1 HSP70 family member highly homologous to Ssa1p and Sse2p; adenyl-nucleotide exchange factor SSE2 2186077 2894318 KLLA0_E24597g Kluyveromyces lactis adenyl-nucleotide exchange factor SSE2 XP_455059.1 2183993 D 28985 CDS KLLA0_E24619g 2894320 complement(2186375..2187091) E 1 NC_006041.1 similar to uniprot|Q02873 Saccharomyces cerevisiae YPL107W Hypothetical ORF; uncharacterized protein 2187091 2894320 KLLA0_E24619g Kluyveromyces lactis uncharacterized protein XP_455061.1 2186375 R 28985 CDS KLLA0_E24641g 2894321 complement(2187515..2188663) E 1 NC_006041.1 similar to uniprot|Q74ZI7 Ashbya gossypii AGR215C AGR215Cp and weakly similar to YBR168W uniprot|P38292 Saccharomyces cerevisiae YBR168W PEX32 Peroxisomal integral membrane protein involved in negative regulation of peroxisome size partially functionally redundant with Pex31p genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p; uncharacterized protein 2188663 2894321 KLLA0_E24641g Kluyveromyces lactis uncharacterized protein XP_455062.1 2187515 R 28985 CDS KLLA0_E24663g 2894322 2188906..2189316 E 1 NC_006041.1 similar to uniprot|P38291 Saccharomyces cerevisiae YBR167C POP7 Subunit of both RNase MRP which cleaves pre-rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends; ribonuclease P/MRP protein subunit POP7 2189316 2894322 KLLA0_E24663g Kluyveromyces lactis ribonuclease P/MRP protein subunit POP7 XP_455063.1 2188906 D 28985 CDS KLLA0_E24685g 2894323 complement(2189395..2189949) E 1 NC_006041.1 similar to uniprot|Q02872 Saccharomyces cerevisiae YPL108W Hypothetical ORF; uncharacterized protein 2189949 2894323 KLLA0_E24685g Kluyveromyces lactis uncharacterized protein XP_455064.1 2189395 R 28985 CDS KLLA0_E24707g 2894311 complement(2190120..2190740) E 1 NC_006041.1 similar to uniprot|P32459 Saccharomyces cerevisiae YIR032C DAL3 Ureidoglycolate hydrolase converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation expression sensitive to nitrogen catabolite repression; ureidoglycolate hydrolase 2190740 2894311 KLLA0_E24707g Kluyveromyces lactis ureidoglycolate hydrolase XP_455065.1 2190120 R 28985 CDS KLLA0_E24729g 2894312 2191359..2192696 E 1 NC_006041.1 similar to uniprot|P20049 Saccharomyces cerevisiae YBR166C TYR1 Step of tyrosine biosynthesis pathway Prephenate dehydrogenase (NADP); prephenate dehydrogenase (NADP(+)) 2192696 2894312 KLLA0_E24729g Kluyveromyces lactis prephenate dehydrogenase (NADP(+)) XP_455066.1 2191359 D 28985 CDS KLLA0_E24751g 2894313 complement(2192929..2193660) E 1 NC_006041.1 weakly similar to uniprot|P38290 Saccharomyces cerevisiae YBR165W UBS1 Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity; uncharacterized protein 2193660 2894313 KLLA0_E24751g Kluyveromyces lactis uncharacterized protein XP_455067.1 2192929 R 28985 CDS KLLA0_E24773g 2894314 2194554..2195105 E 1 NC_006041.1 highly similar to uniprot|P38116 Saccharomyces cerevisiae YBR164C ARL1 Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor; Arf family GTPase ARL1 2195105 2894314 KLLA0_E24773g Kluyveromyces lactis Arf family GTPase ARL1 XP_455068.1 2194554 D 28985 CDS KLLA0_E24795g 2894315 2195975..2197783 E 1 NC_006041.1 similar to uniprot|Q02981 Saccharomyces cerevisiae YPL109C Hypothetical ORF; uncharacterized protein 2197783 2894315 KLLA0_E24795g Kluyveromyces lactis uncharacterized protein XP_455069.1 2195975 D 28985 CDS KLLA0_E24817g 9487332 2197875..2198108 E 1 NC_006041.1 conserved hypothetical protein; uncharacterized protein 2198108 9487332 KLLA0_E24817g Kluyveromyces lactis uncharacterized protein XP_002999421.1 2197875 D 28985 CDS KLLA0_E24861g 2894306 complement(2203694..2204362) E 1 NC_006041.1 some similarities with uniprot|P28319 Saccharomyces cerevisiae YKL096W CWP1 Cell wall mannoprotein linked to a beta-1 3- and beta-1 6-glucan heteropolymer through a phosphodiester bond involved in cell wall organization; uncharacterized protein 2204362 2894306 KLLA0_E24861g Kluyveromyces lactis uncharacterized protein XP_455072.1 2203694 R 28985 CDS KLLA0_E24883g 2894307 2205689..2207464 E 1 NC_006041.1 weakly similar to uniprot|P46996 Saccharomyces cerevisiae YJL163C Hypothetical ORF; uncharacterized protein 2207464 2894307 KLLA0_E24883g Kluyveromyces lactis uncharacterized protein XP_455073.1 2205689 D 28985 CDS KLLA0_E24905g 2894308 complement(2207777..2208331) E 1 NC_006041.1 some similarities with uniprot|P28319 Saccharomyces cerevisiae YKL096W CWP1 Cell wall mannoprotein linked to a beta-1 3- and beta-1 6-glucan heteropolymer through a phosphodiester bond involved in cell wall organization; uncharacterized protein 2208331 2894308 KLLA0_E24905g Kluyveromyces lactis uncharacterized protein XP_455074.1 2207777 R 28985 CDS KLLA0_E24927g 2894309 2209545..2210519 E 1 NC_006041.1 no similarity; uncharacterized protein 2210519 2894309 KLLA0_E24927g Kluyveromyces lactis uncharacterized protein XP_455075.1 2209545 D 28985 CDS KLLA0_E24949g 2894310 2212047..2213501 E 1 NC_006041.1 similar to uniprot|P24031 Saccharomyces cerevisiae YBR092C PHO3 Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin; uncharacterized protein 2213501 2894310 KLLA0_E24949g Kluyveromyces lactis uncharacterized protein XP_455076.1 2212047 D 28985 CDS KLLA0_E24993g 2894298 complement(2214864..2216570) E 1 NC_006041.1 similar to uniprot|P32837 Saccharomyces cerevisiae YDL210W UGA4 Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA) localized to the vacuolar membrane; uncharacterized protein 2216570 2894298 KLLA0_E24993g Kluyveromyces lactis uncharacterized protein XP_455077.1 2214864 R 28985 CDS KLLA0_E25015g 2894299 complement(2219051..2220721) E 1 NC_006041.1 weakly similar to uniprot|P32465 Saccharomyces cerevisiae YHR094C HXT1 Low-affinity glucose transporter of the major facilitator superfamily; uncharacterized protein 2220721 2894299 KLLA0_E25015g Kluyveromyces lactis uncharacterized protein XP_455078.1 2219051 R 28985 CDS KLLA0_E25081g 2894300 2222708..2224600 E 1 NC_006041.1 similar to uniprot|P07337 Kluyveromyces marxianus Beta- glucosidase precursor; uncharacterized protein 2224600 2894300 KLLA0_E25081g Kluyveromyces lactis uncharacterized protein XP_455079.1 2222708 D 28985 CDS KLLA0_E25147g 2894303 2227131..2228147 E 1 NC_006041.1 some similarities with uniprot|P39712 Saccharomyces cerevisiae YAL063C; uncharacterized protein 2228147 2894303 KLLA0_E25147g Kluyveromyces lactis uncharacterized protein XP_455082.1 2227131 D 28985 CDS KLLA0_E25180g 9487335 complement(2229939..2231063) E 1 NC_006041.1 Retrotransposon Gag gene; uncharacterized protein 2231063 9487335 KLLA0_E25180g Kluyveromyces lactis uncharacterized protein XP_002999422.1 2229939 R 28985 CDS KLLA0_F00132g 2894918 2473..3519 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 3519 2894918 KLLA0_F00132g Kluyveromyces lactis uncharacterized protein XP_455085.2 2473 D 28985 CDS KLLA0_F00154g 2895158 4320..5843 F 1 NC_006042.1 similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport; uncharacterized protein 5843 2895158 KLLA0_F00154g Kluyveromyces lactis uncharacterized protein XP_455086.2 4320 D 28985 CDS KLLA0_F00176g 2895159 complement(6530..6748) F 1 NC_006042.1 no similarity; uncharacterized protein 6748 2895159 KLLA0_F00176g Kluyveromyces lactis uncharacterized protein XP_455087.2 6530 R 28985 CDS KLLA0_F00220g 2895157 7833..8273 F 1 NC_006042.1 no similarity; uncharacterized protein 8273 2895157 KLLA0_F00220g Kluyveromyces lactis uncharacterized protein XP_455089.1 7833 D 28985 CDS KLLA0_F00242g 2895214 8992..10260 F 1 NC_006042.1 similar to uniprot|Q06598 Saccharomyces cerevisiae YPR201W ARR3 Arsenite transporter of the plasma membrane required for resistance to arsenic compounds transcription is activated by Arr1p in the presence of arsenite; uncharacterized protein 10260 2895214 KLLA0_F00242g Kluyveromyces lactis uncharacterized protein XP_455090.1 8992 D 28985 CDS KLLA0_F00264g 2895215 12724..13659 F 1 NC_006042.1 similar to uniprot|P40100 Saccharomyces cerevisiae YER185W Hypothetical ORF and to YGR213C uniprot|P53047 Saccharomyces cerevisiae YGR213C RTA1 involved in 7-aminocholesterol resistance; uncharacterized protein 13659 2895215 KLLA0_F00264g Kluyveromyces lactis uncharacterized protein XP_455091.1 12724 D 28985 CDS KLLA0_F00286g 2895216 14519..16138 F 1 NC_006042.1 similar to uniprot|Q12235 Saccharomyces cerevisiae YLL055W Hypothetical ORF; uncharacterized protein 16138 2895216 KLLA0_F00286g Kluyveromyces lactis uncharacterized protein XP_455092.1 14519 D 28985 CDS KLLA0_F00308g 2895132 complement(17067..17537) F 1 NC_006042.1 weakly similar to uniprot|P39718 Saccharomyces cerevisiae YAL055W PEX22; ubiquitin-protein transferase activating protein PEX22 17537 2895132 KLLA0_F00308g Kluyveromyces lactis ubiquitin-protein transferase activating protein PEX22 XP_455093.1 17067 R 28985 CDS KLLA0_F00330g 2895133 17682..18794 F 1 NC_006042.1 similar to uniprot|P48581 Saccharomyces cerevisiae YOR368W RAD17 Checkpoint protein involved in the activation of the DNA damage and meiotic pachytene checkpoints with Mec3p and Ddc1p forms a clamp that is loaded onto partial duplex DNA homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins; uncharacterized protein 18794 2895133 KLLA0_F00330g Kluyveromyces lactis uncharacterized protein XP_455094.1 17682 D 28985 CDS KLLA0_F00352g 2895319 complement(19046..19450) F 1 NC_006042.1 similar to uniprot|P48589 Saccharomyces cerevisiae YOR369C RPS12 Protein component of the small (40S) ribosomal subunit; 40S ribosomal protein eS12 19450 2895319 KLLA0_F00352g Kluyveromyces lactis 40S ribosomal protein eS12 XP_455095.1 19046 R 28985 CDS KLLA0_F00374g 2895130 complement(20124..22511) F 1 NC_006042.1 weakly similar to uniprot|Q08886 Saccharomyces cerevisiae YOR371C GPB1 Proposed beta subunit of the heterotrimeric G protein that interacts with the receptor Grp1p has signaling role in response to nutrients involved in regulation of pseudohyphal growth through cAMP levels homolog of Gpb2p; uncharacterized protein 22511 2895130 KLLA0_F00374g Kluyveromyces lactis uncharacterized protein XP_455096.1 20124 R 28985 CDS KLLA0_F00396g 2895131 complement(23088..24740) F 1 NC_006042.1 weakly similar to uniprot|Q08887 Saccharomyces cerevisiae YOR372C NDD1 Transcriptional activator essential for nuclear division; uncharacterized protein 24740 2895131 KLLA0_F00396g Kluyveromyces lactis uncharacterized protein XP_455097.1 23088 R 28985 CDS KLLA0_F00418g 2895316 26773..29505 F 1 NC_006042.1 weakly similar to uniprot|P32336 Saccharomyces cerevisiae YOR373W NUD1 Component of the spindle pole body outer plaque required for exit from mitosis; uncharacterized protein 29505 2895316 KLLA0_F00418g Kluyveromyces lactis uncharacterized protein XP_455098.1 26773 D 28985 CDS KLLA0_F00440g 2895302 31019..32587 F 1 NC_006042.1 highly similar to uniprot|P46367 Saccharomyces cerevisiae YOR374W ALD4 Mitochondrial aldehyde dehydrogenase that utilizes NADP or NAD equally as coenzymes expression is glucose repressed; aldehyde dehydrogenase (NADP(+)) ALD4 32587 2895302 KLLA0_F00440g Kluyveromyces lactis aldehyde dehydrogenase (NADP(+)) ALD4 XP_455099.1 31019 D 28985 CDS KLLA0_F00462g 2895335 complement(33094..34980) F 1 NC_006042.1 some similarities with uniprot|P27825 Saccharomyces cerevisiae YAL058W CNE1; calnexin 34980 2895335 KLLA0_F00462g Kluyveromyces lactis calnexin XP_455100.1 33094 R 28985 CDS KLLA0_F00484g 2895317 complement(35333..35929) F 1 NC_006042.1 similar to uniprot|P39715 Saccharomyces cerevisiae YAL059W ECM1 Protein of unknown function localized in the nucleoplasm and the nucleolus genetically interacts with MTR2 in 60S ribosomal protein subunit export; uncharacterized protein 35929 2895317 KLLA0_F00484g Kluyveromyces lactis uncharacterized protein XP_455101.1 35333 R 28985 CDS KLLA0_F00506g 2895318 complement(36518..37675) F 1 NC_006042.1 similar to uniprot|P39714 Saccharomyces cerevisiae YAL060W BDH1 NAD-dependent (2R 3R)-2 3-butanediol dehydrogenase; uncharacterized protein 37675 2895318 KLLA0_F00506g Kluyveromyces lactis uncharacterized protein XP_455102.1 36518 R 28985 CDS KLLA0_F00528g 2895386 complement(40081..41226) F 1 NC_006042.1 similar to uniprot|P39713 Saccharomyces cerevisiae YAL061W putative polyol dehydrogenase; uncharacterized protein 41226 2895386 KLLA0_F00528g Kluyveromyces lactis uncharacterized protein XP_455103.1 40081 R 28985 CDS KLLA0_F00572g 2895526 complement(42710..44503) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 44503 2895526 KLLA0_F00572g Kluyveromyces lactis uncharacterized protein XP_455105.1 42710 R 28985 CDS KLLA0_F00594g 2895529 complement(45305..46690) F 1 NC_006042.1 highly similar to uniprot|P07262 Saccharomyces cerevisiae and to YAL062W uniprot|P39708 Saccharomyces cerevisiae, GDH3 NADP(+)-dependent glutamate dehydrogenase; glutamate dehydrogenase (NADP(+)) GDH3 46690 2895529 KLLA0_F00594g Kluyveromyces lactis glutamate dehydrogenase (NADP(+)) GDH3 XP_455106.1 45305 R 28985 CDS KLLA0_F00616g 2895530 48832..50748 F 1 NC_006042.1 some similarities with uniprot|Q12473 Saccharomyces cerevisiae YLL051C; ferric-chelate reductase 50748 2895530 KLLA0_F00616g Kluyveromyces lactis ferric-chelate reductase XP_455107.1 48832 D 28985 CDS KLLA0_F00638g 2895528 51849..52997 F 1 NC_006042.1 weakly similar to uniprot|P53912 Saccharomyces cerevisiae or YLR460C uniprot|P54007 Saccharomyces cerevisiae YLR460C Hypothetical ORFs; uncharacterized protein 52997 2895528 KLLA0_F00638g Kluyveromyces lactis uncharacterized protein XP_455108.1 51849 D 28985 CDS KLLA0_F00660g 2895672 54232..58356 F 1 NC_006042.1 similar to uniprot|Q02979 Saccharomyces cerevisiae YPL110C Hypothetical ORF; glycerophosphocholine phosphodiesterase 58356 2895672 KLLA0_F00660g Kluyveromyces lactis glycerophosphocholine phosphodiesterase XP_455109.1 54232 D 28985 CDS KLLA0_F00682g 2895827 complement(58631..59137) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 59137 2895827 KLLA0_F00682g Kluyveromyces lactis uncharacterized protein XP_455110.1 58631 R 28985 CDS KLLA0_F00704g 2895828 complement(60425..61384) F 1 NC_006042.1 similar to uniprot|P00812 Saccharomyces cerevisiae YPL111W CAR1 Arginase; arginase 61384 2895828 KLLA0_F00704g Kluyveromyces lactis arginase XP_455111.1 60425 R 28985 CDS KLLA0_F00726g 2895829 62828..64123 F 1 NC_006042.1 similar to uniprot|Q6B2A9 Saccharomyces cerevisiae YPL112C PEX25 Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance recruits GTPase Rho1p to peroxisomes induced by oleate interacts with homologous protein Pex27p; uncharacterized protein 64123 2895829 KLLA0_F00726g Kluyveromyces lactis uncharacterized protein XP_455112.1 62828 D 28985 CDS KLLA0_F00748g 2895831 complement(64529..65218) F 1 NC_006042.1 similar to uniprot|Q74ZW6 Ashbya gossypii AGR228C and weakly similar to YOR194C uniprot|P32773 Saccharomyces cerevisiae TOA1 Transcription factor IIA large chain; transcription initiation factor IIA large subunit 65218 2895831 KLLA0_F00748g Kluyveromyces lactis transcription initiation factor IIA large subunit XP_455113.1 64529 R 28985 CDS KLLA0_F00770g 2895832 65967..67853 F 1 NC_006042.1 some similarities with uniprot|Q08581 Saccharomyces cerevisiae YOR195W SLK19 Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; uncharacterized protein 67853 2895832 KLLA0_F00770g Kluyveromyces lactis uncharacterized protein XP_455114.1 65967 D 28985 CDS KLLA0_F00792g 2895830 68605..69786 F 1 NC_006042.1 similar to uniprot|Q02961 Saccharomyces cerevisiae YPL113C Putative dehydrogenase; glyoxylate reductase 69786 2895830 KLLA0_F00792g Kluyveromyces lactis glyoxylate reductase XP_455115.1 68605 D 28985 CDS KLLA0_F00814g 2895836 70536..73673 F 1 NC_006042.1 similar to uniprot|P32873 Saccharomyces cerevisiae YPL115C BEM3 Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; GTPase-activating protein BEM3 73673 2895836 KLLA0_F00814g Kluyveromyces lactis GTPase-activating protein BEM3 XP_455116.1 70536 D 28985 CDS KLLA0_F00836g 2895837 complement(73932..75044) F 1 NC_006042.1 highly similar to uniprot|P32875 Saccharomyces cerevisiae YOR196C LIP5 Protein involved in biosynthesis of the coenzyme lipoic acid; uncharacterized protein 75044 2895837 KLLA0_F00836g Kluyveromyces lactis uncharacterized protein XP_455117.1 73932 R 28985 CDS KLLA0_F00843g 9487428 75779..76075 F 1 NC_006042.1 no similarity; uncharacterized protein 76075 9487428 KLLA0_F00843g Kluyveromyces lactis uncharacterized protein XP_002999423.1 75779 D 28985 CDS KLLA0_F00858g 2895833 complement(78519..80666) F 1 NC_006042.1 similar to uniprot|Q02959 Saccharomyces cerevisiae YPL116W HOS3 Trichostatin A-insensitive homodimeric histone deacetylase (HDAC); histone deacetylase 80666 2895833 KLLA0_F00858g Kluyveromyces lactis histone deacetylase XP_455118.1 78519 R 28985 CDS KLLA0_F00880g 2895835 81734..83035 F 1 NC_006042.1 similar to uniprot|Q08601 Saccharomyces cerevisiae YOR197W MCA1 Putative cysteine protease similar to mammalian caspases; Ca(2+)-dependent cysteine protease MCA1 83035 2895835 KLLA0_F00880g Kluyveromyces lactis Ca(2+)-dependent cysteine protease MCA1 XP_455119.2 81734 D 28985 CDS KLLA0_F00902g 2895838 complement(83326..84729) F 1 NC_006042.1 similar to uniprot|P38934 Saccharomyces cerevisiae YOR198C BFR1 Component of mRNP complexes associated with polyribosomes; uncharacterized protein 84729 2895838 KLLA0_F00902g Kluyveromyces lactis uncharacterized protein XP_455120.1 83326 R 28985 CDS KLLA0_F00924g 2895839 85633..86469 F 1 NC_006042.1 highly similar to uniprot|P15496 Saccharomyces cerevisiae YPL117C IDI1 Isopentenyl diphosphate:dimethylallyl diphosphate isomerase; isopentenyl-diphosphate delta-isomerase IDI1 86469 2895839 KLLA0_F00924g Kluyveromyces lactis isopentenyl-diphosphate delta-isomerase IDI1 XP_455121.1 85633 D 28985 CDS KLLA0_F00946g 2895840 complement(86695..87897) F 1 NC_006042.1 similar to uniprot|P25270 Saccharomyces cerevisiae YOR201C MRM1 Ribose methyltransferase that modifies a functionally critical nucleotide in mitochondrial 21S rRNA; uncharacterized protein 87897 2895840 KLLA0_F00946g Kluyveromyces lactis uncharacterized protein XP_455122.1 86695 R 28985 CDS KLLA0_F00968g 2895841 88262..88927 F 1 NC_006042.1 highly similar to uniprot|P06633 Saccharomyces cerevisiae YOR202W HIS3 Imidazoleglycerol-phosphate dehydratase; imidazoleglycerol-phosphate dehydratase HIS3 88927 2895841 KLLA0_F00968g Kluyveromyces lactis imidazoleglycerol-phosphate dehydratase HIS3 XP_455123.1 88262 D 28985 CDS KLLA0_F00990g 2895842 complement(89152..90210) F 1 NC_006042.1 similar to uniprot|Q02950 Saccharomyces cerevisiae YPL118W MRP51 Mitochondrial ribosomal protein of the large subunit MRP51; mitochondrial 37S ribosomal protein bS1m 90210 2895842 KLLA0_F00990g Kluyveromyces lactis mitochondrial 37S ribosomal protein bS1m XP_455124.1 89152 R 28985 CDS KLLA0_F01012g 2895856 complement(90772..92442) F 1 NC_006042.1 similar to uniprot|P48813 Saccharomyces cerevisiae YDR508C GNP1 High-affinity glutamine permease also transports Leu Ser Thr Cys Met and Asn; uncharacterized protein 92442 2895856 KLLA0_F01012g Kluyveromyces lactis uncharacterized protein XP_455125.1 90772 R 28985 CDS KLLA0_F01034g 2895858 93422..95305 F 1 NC_006042.1 similar to uniprot|P06634 Saccharomyces cerevisiae YOR204W DED1 ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase required for translation initiation of all yeast mRNAs; uncharacterized protein 95305 2895858 KLLA0_F01034g Kluyveromyces lactis uncharacterized protein XP_455126.1 93422 D 28985 CDS KLLA0_F01056g 2895859 complement(96166..97656) F 1 NC_006042.1 similar to uniprot|Q02939 Saccharomyces cerevisiae YPL122C TFB2 subunit of TFIIH and nucleotide excision repair factor 3 complexes; TFIIH/NER complex subunit TFB2 97656 2895859 KLLA0_F01056g Kluyveromyces lactis TFIIH/NER complex subunit TFB2 XP_455127.1 96166 R 28985 CDS KLLA0_F01078g 2895857 98331..101759 F 1 NC_006042.1 highly similar to uniprot|P22276 Saccharomyces cerevisiae YOR207C RET1 second-largest subunit of RNA polymerase III; DNA-directed RNA polymerase III core subunit RET1 101759 2895857 KLLA0_F01078g Kluyveromyces lactis DNA-directed RNA polymerase III core subunit RET1 XP_455128.1 98331 D 28985 CDS KLLA0_F01100g 2895861 complement(101843..102499) F 1 NC_006042.1 similar to uniprot|P32489 Saccharomyces cerevisiae YPL121C MEI5 Meiosis specific protein involved in DMC1-dependent meiotic recombination; uncharacterized protein 102499 2895861 KLLA0_F01100g Kluyveromyces lactis uncharacterized protein XP_455129.1 101843 R 28985 CDS KLLA0_F01122g 2895860 complement(102765..104903) F 1 NC_006042.1 similar to uniprot|P39744 Saccharomyces cerevisiae YOR206W NOC2 Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes as well as a nuclear complex with Noc3p that binds to 66S pre- ribosomes both complexes mediate intranuclear transport of ribosomal precursors; mRNA-binding ribosome synthesis protein NOC2 104903 2895860 KLLA0_F01122g Kluyveromyces lactis mRNA-binding ribosome synthesis protein NOC2 XP_455130.1 102765 R 28985 CDS KLLA0_F01144g 2895862 105169..106983 F 1 NC_006042.1 similar to uniprot|Q08622 Saccharomyces cerevisiae YOR205C FMP38 The authentic non-tagged protein was localized to the mitochondria; uncharacterized protein 106983 2895862 KLLA0_F01144g Kluyveromyces lactis uncharacterized protein XP_455131.1 105169 D 28985 CDS KLLA0_F01166g 2895863 107298..108683 F 1 NC_006042.1 similar to uniprot|Q02948 Saccharomyces cerevisiae YPL120W VPS30 Protein required for sorting and delivery of soluble hydrolases to the vacuole; beclin 1 108683 2895863 KLLA0_F01166g Kluyveromyces lactis beclin 1 XP_455132.1 107298 D 28985 CDS KLLA0_F01188g 2895877 109136..111703 F 1 NC_006042.1 highly similar to uniprot|P21524 Saccharomyces cerevisiae YER070W RNR1 Ribonucleotide-diphosphate reductase (RNR) and to YIL066C uniprot|P21672 Saccharomyces cerevisiae YIL066C RNR3 Ribonucleotide- diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; uncharacterized protein 111703 2895877 KLLA0_F01188g Kluyveromyces lactis uncharacterized protein XP_455133.1 109136 D 28985 CDS KLLA0_F01210g 2895878 112835..114331 F 1 NC_006042.1 similar to uniprot|P37292 Saccharomyces cerevisiae YBR263W SHM1 Serine hydroxymethyltransferase mitochondrial; glycine hydroxymethyltransferase SHM1 114331 2895878 KLLA0_F01210g Kluyveromyces lactis glycine hydroxymethyltransferase SHM1 XP_455134.1 112835 D 28985 CDS KLLA0_F01232g 2895879 complement(114430..115062) F 1 NC_006042.1 similar to uniprot|P36019 Saccharomyces cerevisiae YNL093W YPT53 Involved in vacuolar protein sorting and endocytosis GTP-binding protein of the rab family; Rab family GTPase YPT10 115062 2895879 KLLA0_F01232g Kluyveromyces lactis Rab family GTPase YPT10 XP_455135.1 114430 R 28985 CDS KLLA0_F01254g 2895824 115485..119945 F 1 NC_006042.1 weakly similar to uniprot|P29539 Saccharomyces cerevisiae YBR275C RIF1 Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing deletion results in telomere elongation; DNA-binding protein RIF1 119945 2895824 KLLA0_F01254g Kluyveromyces lactis DNA-binding protein RIF1 XP_455136.1 115485 D 28985 CDS KLLA0_F01276g 2895825 complement(120001..121560) F 1 NC_006042.1 similar to uniprot|P38147 Saccharomyces cerevisiae YBR274W CHK1 checkpoint kinase 1; serine/threonine protein kinase CHK1 121560 2895825 KLLA0_F01276g Kluyveromyces lactis serine/threonine protein kinase CHK1 XP_455137.1 120001 R 28985 CDS KLLA0_F01298g 2896003 121988..123169 F 1 NC_006042.1 similar to uniprot|P38349 Saccharomyces cerevisiae YBR273C UBX7 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; uncharacterized protein 123169 2896003 KLLA0_F01298g Kluyveromyces lactis uncharacterized protein XP_455138.1 121988 D 28985 CDS KLLA0_F01320g 2895930 complement(123277..124602) F 1 NC_006042.1 weakly similar to uniprot|P47048 Saccharomyces cerevisiae YJL049W Hypothetical ORF; uncharacterized protein 124602 2895930 KLLA0_F01320g Kluyveromyces lactis uncharacterized protein XP_455139.1 123277 R 28985 CDS KLLA0_F01342g 2896004 124864..126273 F 1 NC_006042.1 similar to uniprot|P38348 Saccharomyces cerevisiae YBR272C; uncharacterized protein 126273 2896004 KLLA0_F01342g Kluyveromyces lactis uncharacterized protein XP_455140.1 124864 D 28985 CDS KLLA0_F01364g 2896039 complement(126312..129533) F 1 NC_006042.1 highly similar to uniprot|P47047 Saccharomyces cerevisiae YJL050W MTR4 Dead-box family ATP dependent helicase required for mRNA export from the nucleus co-factor of the exosome complex required for 3' end formation of 5.8S rRNA; ATP-dependent RNA helicase MTR4 129533 2896039 KLLA0_F01364g Kluyveromyces lactis ATP-dependent RNA helicase MTR4 XP_455141.1 126312 R 28985 CDS KLLA0_F01386g 2896040 complement(132122..134323) F 1 NC_006042.1 weakly similar to uniprot|P47046 Saccharomyces cerevisiae YJL051W Protein of unknown function localized to the bud tip mRNA is targeted to the bud via the mRNA transport system involving She2p; uncharacterized protein 134323 2896040 KLLA0_F01386g Kluyveromyces lactis uncharacterized protein XP_455142.1 132122 R 28985 CDS KLLA0_F01408g 2896026 135424..136302 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 136302 2896026 KLLA0_F01408g Kluyveromyces lactis uncharacterized protein XP_455143.1 135424 D 28985 CDS KLLA0_F01419g 2896041 complement(136295..137209) F 1 NC_006042.1 highly similar to uniprot|P40335 Saccharomyces cerevisiae YJL053W PEP8 vacuolar protein sorting protein that forms part of the multimeric membrane-associated retromer complex; retromer subunit PEP8 137209 2896041 KLLA0_F01419g Kluyveromyces lactis retromer subunit PEP8 XP_455144.1 136295 R 28985 CDS KLLA0_F01441g 2896042 complement(137575..138990) F 1 NC_006042.1 weakly similar to uniprot|P47045 Saccharomyces cerevisiae YJL054W TIM54 Translocase Inner Membrane 54kD Translocase for the insertion of proteins into the mitochondrial inner membrane; uncharacterized protein 138990 2896042 KLLA0_F01441g Kluyveromyces lactis uncharacterized protein XP_455145.1 137575 R 28985 CDS KLLA0_F01463g 2896037 140343..142688 F 1 NC_006042.1 some similarities with uniprot|P47043 Saccharomyces cerevisiae YJL056C ZAP1 Zinc-regulated transcription factor binds to zinc-responsive promoter elements to induce transcription of certain genes in the presence of zinc regulates its own transcription contains seven zinc- finger domains; uncharacterized protein 142688 2896037 KLLA0_F01463g Kluyveromyces lactis uncharacterized protein XP_455146.1 140343 D 28985 CDS KLLA0_F01485g 2896038 complement(143345..143830) F 1 NC_006042.1 weakly similar to uniprot|Q02486 Saccharomyces cerevisiae YMR072W ABF2 Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination member of HMG1 DNA-binding protein family activity may be regulated by protein kinase A phosphorylation; DNA-binding protein ABF2 143830 2896038 KLLA0_F01485g Kluyveromyces lactis DNA-binding protein ABF2 XP_455147.1 143345 R 28985 CDS KLLA0_F01507g 2896056 144356..145774 F 1 NC_006042.1 some similarities with uniprot|P47042 Saccharomyces cerevisiae YJL057C probable serine/threonine kinase; protein kinase IKS1 145774 2896056 KLLA0_F01507g Kluyveromyces lactis protein kinase IKS1 XP_455148.1 144356 D 28985 CDS KLLA0_F01529g 2896027 145940..146662 F 1 NC_006042.1 some similarities with uniprot|P38346 Saccharomyces cerevisiae YBR270C BIT2 Hypothetical ORF; uncharacterized protein 146662 2896027 KLLA0_F01529g Kluyveromyces lactis uncharacterized protein XP_455149.1 145940 D 28985 CDS KLLA0_F01551g 2895071 complement(146711..147874) F 1 NC_006042.1 similar to uniprot|P47040 Saccharomyces cerevisiae YJL059W YHC3 Homolog of human CLN3 vacuolar/lysosomal membrane protein; amino acid transporter YHC3 147874 2895071 KLLA0_F01551g Kluyveromyces lactis amino acid transporter YHC3 XP_455150.1 146711 R 28985 CDS KLLA0_F01573g 2895303 148328..149113 F 1 NC_006042.1 no similarity; uncharacterized protein 149113 2895303 KLLA0_F01573g Kluyveromyces lactis uncharacterized protein XP_455151.1 148328 D 28985 CDS KLLA0_F01595g 2895334 151557..153518 F 1 NC_006042.1 weakly similar to uniprot|P42835 Saccharomyces cerevisiae YNL327W EGT2 Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner; uncharacterized protein 153518 2895334 KLLA0_F01595g Kluyveromyces lactis uncharacterized protein XP_455152.1 151557 D 28985 CDS KLLA0_F01617g 2895821 complement(154025..155359) F 1 NC_006042.1 highly similar to uniprot|P47039 Saccharomyces cerevisiae YJL060W BNA3 Arylformamidase; kynurenine--oxoglutarate transaminase 155359 2895821 KLLA0_F01617g Kluyveromyces lactis kynurenine--oxoglutarate transaminase XP_455153.1 154025 R 28985 CDS KLLA0_F01639g 2895822 156067..156462 F 1 NC_006042.1 similar to uniprot|P38345 Saccharomyces cerevisiae YBR269C FMP21 The authentic non-tagged protein was localized to the mitochondria; uncharacterized protein 156462 2895822 KLLA0_F01639g Kluyveromyces lactis uncharacterized protein XP_455154.1 156067 D 28985 CDS KLLA0_F01661g 2895945 complement(156609..158672) F 1 NC_006042.1 weakly similar to uniprot|P40368 Saccharomyces cerevisiae YJL061W NUP82 Subunit of the nuclear pore complex (NPC) forms a subcomplex with Nup159p and Nsp1p interacts with Nup116p and is required for proper localization of Nup116p in the NPC; linker nucleoporin NUP82 158672 2895945 KLLA0_F01661g Kluyveromyces lactis linker nucleoporin NUP82 XP_455155.1 156609 R 28985 CDS KLLA0_F01683g 2895826 complement(158967..159263) F 1 NC_006042.1 similar to uniprot|P36532 Saccharomyces cerevisiae YBR268W MRPL37 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein mL54 159263 2895826 KLLA0_F01683g Kluyveromyces lactis mitochondrial 54S ribosomal protein mL54 XP_455156.1 158967 R 28985 CDS KLLA0_F01705g 2895006 complement(159469..161832) F 1 NC_006042.1 similar to uniprot|P40367 Saccharomyces cerevisiae YJL062W LAS21 Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure mutations affect cell wall integrity; mannose-ethanolamine phosphotransferase LAS21 161832 2895006 KLLA0_F01705g Kluyveromyces lactis mannose-ethanolamine phosphotransferase LAS21 XP_455157.1 159469 R 28985 CDS KLLA0_F01727g 2895345 complement(162226..163440) F 1 NC_006042.1 similar to uniprot|P38344 Saccharomyces cerevisiae YBR267W REI1 Protein of unknown function involved in bud growth in the mitotic signaling network proposed negative regulator of Swe1p and Gin4p contains dispersed C2H2 zinc finger domains; uncharacterized protein 163440 2895345 KLLA0_F01727g Kluyveromyces lactis uncharacterized protein XP_455158.1 162226 R 28985 CDS KLLA0_F01749g 2895346 complement(163821..164762) F 1 NC_006042.1 similar to uniprot|P38342 Saccharomyces cerevisiae YBR265W TSC10 catalyzes the second step in the synthesis of phytosphingosine 3-ketosphinganine reductase; 3-dehydrosphinganine reductase 164762 2895346 KLLA0_F01749g Kluyveromyces lactis 3-dehydrosphinganine reductase XP_455159.1 163821 R 28985 CDS KLLA0_F01771g 2894931 complement(165000..165266) F 1 NC_006042.1 highly similar to uniprot|Q3E7B2 Saccharomyces cerevisiae YJL062W-A Hypothetical ORF; uncharacterized protein 165266 2894931 KLLA0_F01771g Kluyveromyces lactis uncharacterized protein XP_455160.1 165000 R 28985 CDS KLLA0_F01793g 2894792 165790..166530 F 1 NC_006042.1 similar to uniprot|P22353 Saccharomyces cerevisiae YJL063C MRPL8 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein bL17m 166530 2894792 KLLA0_F01793g Kluyveromyces lactis mitochondrial 54S ribosomal protein bL17m XP_455161.1 165790 D 28985 CDS KLLA0_F01815g 2895283 166880..167947 F 1 NC_006042.1 similar to uniprot|P53206 Saccharomyces cerevisiae YGR012W Hypothetical ORF; uncharacterized protein 167947 2895283 KLLA0_F01815g Kluyveromyces lactis uncharacterized protein XP_455162.1 166880 D 28985 CDS KLLA0_F01837g 2895285 complement(168045..170255) F 1 NC_006042.1 similar to uniprot|P38148 Saccharomyces cerevisiae YBR276C PPS1 Protein phosphatase with specificity for serine threonine and tyrosine residues has a role in the DNA synthesis phase of the cell cycle; tyrosine/serine/threonine protein phosphatase PPS1 170255 2895285 KLLA0_F01837g Kluyveromyces lactis tyrosine/serine/threonine protein phosphatase PPS1 XP_455163.1 168045 R 28985 CDS KLLA0_F01859g 2895286 170883..171383 F 1 NC_006042.1 some similarities with uniprot|P27344 Saccharomyces cerevisiae YBR278W DPB3 Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing mRNA abundance peaks at the G1/S boundary of the cell cycle; DNA polymerase epsilon noncatalytic subunit 171383 2895286 KLLA0_F01859g Kluyveromyces lactis DNA polymerase epsilon noncatalytic subunit XP_455164.1 170883 D 28985 CDS KLLA0_F01881g 2895284 171694..172395 F 1 NC_006042.1 similar to uniprot|P40364 Saccharomyces cerevisiae YJL066C MPM1 Mitochondrial membrane protein of unknown function contains no hydrophobic stretches; uncharacterized protein 172395 2895284 KLLA0_F01881g Kluyveromyces lactis uncharacterized protein XP_455165.1 171694 D 28985 CDS KLLA0_F01903g 2895287 172931..174667 F 1 NC_006042.1 similar to uniprot|P27614 Saccharomyces cerevisiae YJL172W CPS1 Vacuolar carboxypeptidase yscS expression is induced under low-nitrogen conditions; uncharacterized protein 174667 2895287 KLLA0_F01903g Kluyveromyces lactis uncharacterized protein XP_455166.1 172931 D 28985 CDS KLLA0_F01925g 2895104 175031..176317 F 1 NC_006042.1 similar to uniprot|P38351 Saccharomyces cerevisiae YBR279W PAF1 RNA polymerase II-associated protein defines a large complex that is biochemically and functionally distinct from the Srb-Mediator form of Pol II holoenzyme and is required for full expression of a subset of cell cycle-regulated genes; uncharacterized protein 176317 2895104 KLLA0_F01925g Kluyveromyces lactis uncharacterized protein XP_455167.1 175031 D 28985 CDS KLLA0_F01947g 2894919 176686..177573 F 1 NC_006042.1 highly similar to gnl|GLV|CAGL0J05324g Candida glabrata CAGL0J05324g and similar to YJL068C uniprot|P40363 Saccharomyces cerevisiae YJL068C Hypothetical ORF; S-formylglutathione hydrolase 177573 2894919 KLLA0_F01947g Kluyveromyces lactis S-formylglutathione hydrolase XP_455168.1 176686 D 28985 CDS KLLA0_F01969g 2894920 complement(177739..179541) F 1 NC_006042.1 similar to uniprot|P38352 Saccharomyces cerevisiae YBR280C Hypothetical ORF; SCF ubiquitin ligase complex subunit SAF1 179541 2894920 KLLA0_F01969g Kluyveromyces lactis SCF ubiquitin ligase complex subunit SAF1 XP_455169.1 177739 R 28985 CDS KLLA0_F01991g 2894906 complement(179904..182510) F 1 NC_006042.1 similar to uniprot|P38149 Saccharomyces cerevisiae YBR281C Hypothetical ORF; glutamine amidotransferase subunit DUG2 182510 2894906 KLLA0_F01991g Kluyveromyces lactis glutamine amidotransferase subunit DUG2 XP_455170.1 179904 R 28985 CDS KLLA0_F02013g 2894905 183770..185470 F 1 NC_006042.1 similar to uniprot|P40362 Saccharomyces cerevisiae YJL069C UTP18 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA based on computational analysis of large-scale protein-protein interaction data; uncharacterized protein 185470 2894905 KLLA0_F02013g Kluyveromyces lactis uncharacterized protein XP_455171.1 183770 D 28985 CDS KLLA0_F02035g 2894827 185846..186283 F 1 NC_006042.1 similar to uniprot|P36526 Saccharomyces cerevisiae YBR282W MRPL27 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein mL41 186283 2894827 KLLA0_F02035g Kluyveromyces lactis mitochondrial 54S ribosomal protein mL41 XP_455172.1 185846 D 28985 CDS KLLA0_F02057g 2894828 complement(join(186620..188064,188257..188266)) F 1 NC_006042.1 highly similar to uniprot|P38353 Saccharomyces cerevisiae YBR283C SSH1 Subunit of the Ssh1 translocon complex Sec61p homolog involved in co-translational pathway of protein translocation not essential; uncharacterized protein 188266 2894828 KLLA0_F02057g Kluyveromyces lactis uncharacterized protein XP_455173.2 186620 R 28985 CDS KLLA0_F02079g 2894826 188816..189100 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 189100 2894826 KLLA0_F02079g Kluyveromyces lactis uncharacterized protein XP_455174.1 188816 D 28985 CDS KLLA0_F02101g 2894825 189413..190096 F 1 NC_006042.1 similar to uniprot|P38340 Saccharomyces cerevisiae YBR261C Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; N-terminal protein methyltransferase 190096 2894825 KLLA0_F02101g Kluyveromyces lactis N-terminal protein methyltransferase XP_455175.1 189413 D 28985 CDS KLLA0_F02123g 2894824 191154..193190 F 1 NC_006042.1 similar to uniprot|P38339 Saccharomyces cerevisiae YBR260C RGD1 GTPase-activating protein (RhoGAP) for Rho3p and Rho4p possibly involved in control of actin cytoskeleton organization; GTPase-activating protein RGD1 193190 2894824 KLLA0_F02123g Kluyveromyces lactis GTPase-activating protein RGD1 XP_455176.1 191154 D 28985 CDS KLLA0_F02145g 2894822 complement(193239..195395) F 1 NC_006042.1 some similarities with uniprot|P47050 Saccharomyces cerevisiae YJL047C RTT101 Cullin family member subunit of a complex containing ubiquitin ligase activity binds HRT1 and is modified by the ubiquitin like protein RUB1 Regulator of Ty1 Transposition Regulator of Ty1 Transposition; uncharacterized protein 195395 2894822 KLLA0_F02145g Kluyveromyces lactis uncharacterized protein XP_455177.1 193239 R 28985 CDS KLLA0_F02167g 2894823 complement(195562..197445) F 1 NC_006042.1 no similarity; uncharacterized protein 197445 2894823 KLLA0_F02167g Kluyveromyces lactis uncharacterized protein XP_455178.1 195562 R 28985 CDS KLLA0_F02189g 2894821 197699..198085 F 1 NC_006042.1 some similarities with uniprot|P38337 Saccharomyces cerevisiae YBR258C SHG1 Subunit of the COMPASS complex which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; uncharacterized protein 198085 2894821 KLLA0_F02189g Kluyveromyces lactis uncharacterized protein XP_455179.1 197699 D 28985 CDS KLLA0_F02211g 2894820 complement(198132..198956) F 1 NC_006042.1 similar to uniprot|P38336 Saccharomyces cerevisiae YBR257W POP4 Subunit of both RNase MRP which cleaves pre-rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends binds to the RPR1 RNA subunit in Rnase P; RNase P/RNase MRP complex subunit 198956 2894820 KLLA0_F02211g Kluyveromyces lactis RNase P/RNase MRP complex subunit XP_455180.1 198132 R 28985 CDS KLLA0_F02233g 2894818 199224..200429 F 1 NC_006042.1 similar to uniprot|P47051 Saccharomyces cerevisiae YJL046W Hypothetical ORF; uncharacterized protein 200429 2894818 KLLA0_F02233g Kluyveromyces lactis uncharacterized protein XP_455181.1 199224 D 28985 CDS KLLA0_F02255g 2894819 complement(200492..202426) F 1 NC_006042.1 similar to uniprot|P43606 Saccharomyces cerevisiae YFR029W PTR3 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; uncharacterized protein 202426 2894819 KLLA0_F02255g Kluyveromyces lactis uncharacterized protein XP_455182.1 200492 R 28985 CDS KLLA0_F02277g 2894817 203211..204107 F 1 NC_006042.1 no similarity; uncharacterized protein 204107 2894817 KLLA0_F02277g Kluyveromyces lactis uncharacterized protein XP_455183.1 203211 D 28985 CDS KLLA0_F02299g 2894816 205549..208167 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 208167 2894816 KLLA0_F02299g Kluyveromyces lactis uncharacterized protein XP_455184.1 205549 D 28985 CDS KLLA0_F02321g 2895823 208858..209721 F 1 NC_006042.1 similar to uniprot|P46669 Saccharomyces cerevisiae YOR340C RPA43 RNA polymerase I subunit A43; DNA-directed RNA polymerase I subunit RPA43 209721 2895823 KLLA0_F02321g Kluyveromyces lactis DNA-directed RNA polymerase I subunit RPA43 XP_455185.1 208858 D 28985 CDS KLLA0_F02343g 2895008 209983..210849 F 1 NC_006042.1 similar to uniprot|P39731 Saccharomyces cerevisiae YAL034W-A MTW1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules critical to kinetochore assembly; MIND complex subunit MTW1 210849 2895008 KLLA0_F02343g Kluyveromyces lactis MIND complex subunit MTW1 XP_455186.1 209983 D 28985 CDS KLLA0_F02365g 2895009 complement(211473..212747) F 1 NC_006042.1 similar to uniprot|Q06855 Saccharomyces cerevisiae YOR338W Hypothetical ORF; uncharacterized protein 212747 2895009 KLLA0_F02365g Kluyveromyces lactis uncharacterized protein XP_455187.1 211473 R 28985 CDS KLLA0_F02387g 2894907 complement(213669..215852) F 1 NC_006042.1 similar to uniprot|P47988 Saccharomyces cerevisiae YOR337W TEA1 Mutants are defective in Ty1 Enhancer-mediated Activation Ty1 enhancer activator and to YLR098C uniprot|P43634 Saccharomyces cerevisiae YLR098C CHA4 Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain; DNA-binding transcriptional activator or CHA1; uncharacterized protein 215852 2894907 KLLA0_F02387g Kluyveromyces lactis uncharacterized protein XP_455188.1 213669 R 28985 CDS KLLA0_F02409g 2894908 complement(216348..220091) F 1 NC_006042.1 weakly similar to uniprot|P22023 Saccharomyces cerevisiae YOR336W KRE5 Protein required for beta-1 6 glucan biosynthesis mutations result in aberrant morphology and severe growth defects; uncharacterized protein 220091 2894908 KLLA0_F02409g Kluyveromyces lactis uncharacterized protein XP_455189.1 216348 R 28985 CDS KLLA0_F02431g 2894909 220848..223718 F 1 NC_006042.1 highly similar to uniprot|P40825 Saccharomyces cerevisiae YOR335C ALA1 Cytoplasmic alanyl-tRNA synthetase required for protein synthesis point mutation (cdc64-1 allele) causes cell cycle arrest at G1 lethality of null mutation is functionally complemented by human homolog; alanine--tRNA ligase 223718 2894909 KLLA0_F02431g Kluyveromyces lactis alanine--tRNA ligase XP_455190.1 220848 D 28985 CDS KLLA0_F02453g 2894910 224029..224673 F 1 NC_006042.1 similar to uniprot|P28005 Saccharomyces cerevisiae YAL033W POP5 Subunit of both RNase MRP which cleaves pre-rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends; RNA-binding protein POP5 224673 2894910 KLLA0_F02453g Kluyveromyces lactis RNA-binding protein POP5 XP_455191.1 224029 D 28985 CDS KLLA0_F02475g 2894911 complement(224749..226041) F 1 NC_006042.1 similar to uniprot|P28004 Saccharomyces cerevisiae YAL032C PRP45 Ortholog of human transcriptional coactivator SKIP can activate transcription of a reporter gene interacts with splicing factors Prp22p and Prp46p; mRNA splicing protein PRP45 226041 2894911 KLLA0_F02475g Kluyveromyces lactis mRNA splicing protein PRP45 XP_455192.1 224749 R 28985 CDS KLLA0_F02497g 2894912 complement(226225..228498) F 1 NC_006042.1 some similarities with uniprot|P39732 Saccharomyces cerevisiae YAL031C FUN21 Cytoplasmic protein of unknown function potential Cdc28p substrate; protein phosphatase regulator GIP4 228498 2894912 KLLA0_F02497g Kluyveromyces lactis protein phosphatase regulator GIP4 XP_455193.1 226225 R 28985 CDS KLLA0_F02519g 2894913 complement(228859..230187) F 1 NC_006042.1 similar to uniprot|Q01926 Saccharomyces cerevisiae YOR334W MRS2 Mitochondrial inner membrane Mg(2) channel required for maintenance of intramitochondrial Mg(2) concentrations at the correct level to support splicing of group II introns; uncharacterized protein 230187 2894913 KLLA0_F02519g Kluyveromyces lactis uncharacterized protein XP_455194.1 228859 R 28985 CDS KLLA0_F02541g 2894914 complement(230613..231302) F 1 NC_006042.1 similar to uniprot|P22203 Saccharomyces cerevisiae YOR332W VMA4 vacuolar ATPase V1 domain subunit E (27 kDa); H(+)-transporting V1 sector ATPase subunit E 231302 2894914 KLLA0_F02541g Kluyveromyces lactis H(+)-transporting V1 sector ATPase subunit E XP_455195.1 230613 R 28985 CDS KLLA0_F02596g 2894917 235864..237840 F 1 NC_006042.1 some similarities with uniprot|P34758 Saccharomyces cerevisiae YOR329C SCD5 Multicopy suppressor of clathrin deficiency and of ts ipl1 mutants; uncharacterized protein 237840 2894917 KLLA0_F02596g Kluyveromyces lactis uncharacterized protein XP_455198.1 235864 D 28985 CDS KLLA0_F02610g 9487382 complement(238258..238551) F 1 NC_006042.1 no similarity; uncharacterized protein 238551 9487382 KLLA0_F02610g Kluyveromyces lactis uncharacterized protein XP_002999424.1 238258 R 28985 CDS KLLA0_F02640g 2896006 240871..241524 F 1 NC_006042.1 weakly similar to uniprot|Q03362 Saccharomyces cerevisiae YDR476C Hypothetical ORF; uncharacterized protein 241524 2896006 KLLA0_F02640g Kluyveromyces lactis uncharacterized protein XP_455199.1 240871 D 28985 CDS KLLA0_F02662g 2896007 241804..242565 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 242565 2896007 KLLA0_F02662g Kluyveromyces lactis uncharacterized protein XP_455200.1 241804 D 28985 CDS KLLA0_F02684g 2896008 242962..245301 F 1 NC_006042.1 some similarities with uniprot|Q99248 Saccharomyces cerevisiae YOR019W Hypothetical ORF; uncharacterized protein 245301 2896008 KLLA0_F02684g Kluyveromyces lactis uncharacterized protein XP_455201.1 242962 D 28985 CDS KLLA0_F02706g 2896009 245783..248653 F 1 NC_006042.1 uniprot|Q96W95 Kluyveromyces lactis MSH2 Mismatch repair protein Msh2p; mismatch repair ATPase MSH2 248653 2896009 KLLA0_F02706g Kluyveromyces lactis mismatch repair ATPase MSH2 XP_455202.1 245783 D 28985 CDS KLLA0_F02728g 2896010 249240..250232 F 1 NC_006042.1 similar to uniprot|P38115 Saccharomyces cerevisiae YBR149W ARA1 Large subunit of NADP dependent arabinose dehydrogenase involved in carbohydrate metabolism small subunit is unidentified; D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA1 250232 2896010 KLLA0_F02728g Kluyveromyces lactis D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA1 XP_455203.1 249240 D 28985 CDS KLLA0_F02750g 2896011 complement(250368..253814) F 1 NC_006042.1 some similarities with uniprot|Q12180 Saccharomyces cerevisiae YOL089C HAL9 Putative transcription factor containing a zinc finger overexpression increases salt tolerance through increased expression of the ENA1 (Na /Li extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression; uncharacterized protein 253814 2896011 KLLA0_F02750g Kluyveromyces lactis uncharacterized protein XP_455204.1 250368 R 28985 CDS KLLA0_F02772g 2896012 255901..256842 F 1 NC_006042.1 similar to uniprot|P38281 Saccharomyces cerevisiae YBR151W APD1 Protein of unknown function required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide localizes to both cytoplasm and nucleus; uncharacterized protein 256842 2896012 KLLA0_F02772g Kluyveromyces lactis uncharacterized protein XP_455205.1 255901 D 28985 CDS KLLA0_F02794g 2896013 complement(257091..257873) F 1 NC_006042.1 similar to uniprot|Q99316 Saccharomyces cerevisiae YOL088C MPD2 Protein disulfide isomerase; protein disulfide isomerase MPD2 257873 2896013 KLLA0_F02794g Kluyveromyces lactis protein disulfide isomerase MPD2 XP_455206.1 257091 R 28985 CDS KLLA0_F02816g 2896014 complement(258214..261069) F 1 NC_006042.1 some similarities with uniprot|P42946 Saccharomyces cerevisiae YJL108C PRM10 Pheromone-regulated protein predicted to have 5 transmembrane segments; uncharacterized protein 261069 2896014 KLLA0_F02816g Kluyveromyces lactis uncharacterized protein XP_455207.1 258214 R 28985 CDS KLLA0_F02838g 2896015 264329..266596 F 1 NC_006042.1 similar to uniprot|P32581 Saccharomyces cerevisiae YJL106W IME2 Serine/threonine protein kinase involved in activation of meiosis associates with Ime1p and mediates its stability activates Ndt80p IME2 expression is positively regulated by Ime1p; protein kinase IME2 266596 2896015 KLLA0_F02838g Kluyveromyces lactis protein kinase IME2 XP_455208.1 264329 D 28985 CDS KLLA0_F02860g 2896016 267100..268401 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 268401 2896016 KLLA0_F02860g Kluyveromyces lactis uncharacterized protein XP_455209.1 267100 D 28985 CDS KLLA0_F02882g 2895775 269162..271552 F 1 NC_006042.1 similar to uniprot|P36124 Saccharomyces cerevisiae YKR029C SET3; uncharacterized protein 271552 2895775 KLLA0_F02882g Kluyveromyces lactis uncharacterized protein XP_455210.1 269162 D 28985 CDS KLLA0_F02904g 2895776 complement(271837..272994) F 1 NC_006042.1 similar to uniprot|Q03151 Saccharomyces cerevisiae YMR097C MTG1 Peripheral GTPase of the mitochondrial inner membrane; uncharacterized protein 272994 2895776 KLLA0_F02904g Kluyveromyces lactis uncharacterized protein XP_455211.1 271837 R 28985 CDS KLLA0_F02926g 2895777 273193..274212 F 1 NC_006042.1 similar to uniprot|P34253 Saccharomyces cerevisiae YKL110C KTI12 Protein associated with the RNA polymerase II Elongator complex involved in sensitivity to G1 arrest induced by Kluyveromyces lactis toxin zymocin; uncharacterized protein 274212 2895777 KLLA0_F02926g Kluyveromyces lactis uncharacterized protein XP_455212.1 273193 D 28985 CDS KLLA0_F02948g 2895778 complement(274341..276029) F 1 NC_006042.1 weakly similar to uniprot|Q03153 Saccharomyces cerevisiae YMR098C Hypothetical ORF; uncharacterized protein 276029 2895778 KLLA0_F02948g Kluyveromyces lactis uncharacterized protein XP_455213.1 274341 R 28985 CDS KLLA0_F02970g 2894945 complement(276288..277772) F 1 NC_006042.1 uniprot|P26375 Kluyveromyces lactis KLLA0F02970g BAF1 Transcription factor BAF1; DNA-binding protein ABF1 277772 2894945 KLLA0_F02970g Kluyveromyces lactis DNA-binding protein ABF1 XP_455214.1 276288 R 28985 CDS KLLA0_F02992g 2895779 278441..279586 F 1 NC_006042.1 similar to uniprot|P26793 Saccharomyces cerevisiae YKL113C RAD27 5' to 3' exonuclease 5' flap endonuclease required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair member of the S. pombe RAD2/FEN1 family; multifunctional nuclease RAD27 279586 2895779 KLLA0_F02992g Kluyveromyces lactis multifunctional nuclease RAD27 XP_455215.1 278441 D 28985 CDS KLLA0_F03014g 2895780 complement(280155..282614) F 1 NC_006042.1 similar to uniprot|P32497 Saccharomyces cerevisiae YMR309C NIP1 Subunit of the eukaryotic translation initiation factor 3 (eIF3) involved in the assembly of preinitiation complex and start codon selection; translation initiation factor eIF3 core subunit c 282614 2895780 KLLA0_F03014g Kluyveromyces lactis translation initiation factor eIF3 core subunit c XP_455216.1 280155 R 28985 CDS KLLA0_F03036g 2895781 complement(283504..284439) F 1 NC_006042.1 highly similar to uniprot|P15703 Saccharomyces cerevisiae YGR282C BGL2 Endo-beta-1 3-glucanase major protein of the cell wall involved in cell wall maintenance; glucan 1,3-beta-glucosidase 284439 2895781 KLLA0_F03036g Kluyveromyces lactis glucan 1,3-beta-glucosidase XP_455217.1 283504 R 28985 CDS KLLA0_F03058g 2895782 complement(284859..286088) F 1 NC_006042.1 similar to uniprot|Q04867 Saccharomyces cerevisiae YMR310C Hypothetical ORF; uncharacterized protein 286088 2895782 KLLA0_F03058g Kluyveromyces lactis uncharacterized protein XP_455218.1 284859 R 28985 CDS KLLA0_F03080g 2895783 complement(286585..287169) F 1 NC_006042.1 similar to uniprot|P41818 Saccharomyces cerevisiae YMR311C GLC8 Regulatory subunit of protein phosphatase 1 (Glc7p) involved in glycogen metabolism and chromosome segregation proposed to regulate Glc7p activity via conformational alteration ortholog of the mammalian protein phosphatase inhibitor 2; uncharacterized protein 287169 2895783 KLLA0_F03080g Kluyveromyces lactis uncharacterized protein XP_455219.1 286585 R 28985 CDS KLLA0_F03102g 2895784 complement(287943..288860) F 1 NC_006042.1 similar to uniprot|P53337 Saccharomyces cerevisiae YGR284C ERV29 Protein localized to COPII-coated vesicles involved in vesicle formation and incorporation of specific secretory cargo; uncharacterized protein 288860 2895784 KLLA0_F03102g Kluyveromyces lactis uncharacterized protein XP_455220.1 287943 R 28985 CDS KLLA0_F03124g 2895709 complement(289514..290815) F 1 NC_006042.1 highly similar to uniprot|P32527 Saccharomyces cerevisiae YGR285C ZUO1 Cytosolic ribosome-associated chaperone contains a DnaJ domain together with Ssz1p acts as a chaperone for nascent polypeptide chains; zuotin 290815 2895709 KLLA0_F03124g Kluyveromyces lactis zuotin XP_455221.1 289514 R 28985 CDS KLLA0_F03146g 2895710 complement(291215..292882) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 292882 2895710 KLLA0_F03146g Kluyveromyces lactis uncharacterized protein XP_455222.1 291215 R 28985 CDS KLLA0_F03168g 2895711 294261..295817 F 1 NC_006042.1 similar to uniprot|Q08268 Saccharomyces cerevisiae YOL119C MCH4 or uniprot|Q08777 Saccharomyces cerevisiae YOR306C MCH5; uncharacterized protein 295817 2895711 KLLA0_F03168g Kluyveromyces lactis uncharacterized protein XP_455223.1 294261 D 28985 CDS KLLA0_F03179g 9487423 complement(296121..296402) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 296402 9487423 KLLA0_F03179g Kluyveromyces lactis uncharacterized protein XP_002999425.1 296121 R 28985 CDS KLLA0_F03190g 2895712 complement(296883..300236) F 1 NC_006042.1 similar to uniprot|P03965 Saccharomyces cerevisiae YJR109C CPA2 Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2 300236 2895712 KLLA0_F03190g Kluyveromyces lactis carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2 XP_455224.1 296883 R 28985 CDS KLLA0_F03212g 2895713 302915..303832 F 1 NC_006042.1 similar to uniprot|P33303 Saccharomyces cerevisiae YJR095W SFC1 Mitochondrial succinate-fumarate transporter transports succinate into and fumarate out of the mitochondrion required for ethanol and acetate utilization; uncharacterized protein 303832 2895713 KLLA0_F03212g Kluyveromyces lactis uncharacterized protein XP_455225.1 302915 D 28985 CDS KLLA0_F03234g 2895714 complement(304531..305034) F 1 NC_006042.1 no similarity; uncharacterized protein 305034 2895714 KLLA0_F03234g Kluyveromyces lactis uncharacterized protein XP_455226.1 304531 R 28985 CDS KLLA0_F03256g 2895715 306731..307588 F 1 NC_006042.1 highly similar to uniprot|P47137 Saccharomyces cerevisiae YJR096W; aldo-keto reductase superfamily protein 307588 2895715 KLLA0_F03256g Kluyveromyces lactis aldo-keto reductase superfamily protein XP_455227.1 306731 D 28985 CDS KLLA0_F03311g 2895718 311639..313267 F 1 NC_006042.1 similar to uniprot|P53943 Saccharomyces cerevisiae YNL065W AQR1 Plasma membrane transporter of the major facilitator superfamily that confers resistance to short-chain monocarboxylic acids and quinidine; uncharacterized protein 313267 2895718 KLLA0_F03311g Kluyveromyces lactis uncharacterized protein XP_455230.1 311639 D 28985 CDS KLLA0_F03333g 2895719 complement(313991..315220) F 1 NC_006042.1 highly similar to uniprot|P25491 Saccharomyces cerevisiae YNL064C YDJ1 yeast dnaJ homolog (nuclear envelope protein) heat shock protein; type I HSP40 co-chaperone YDJ1 315220 2895719 KLLA0_F03333g Kluyveromyces lactis type I HSP40 co-chaperone YDJ1 XP_455231.1 313991 R 28985 CDS KLLA0_F03355g 2895720 316145..317032 F 1 NC_006042.1 similar to uniprot|P53944 Saccharomyces cerevisiae YNL063W MTQ1; S-adenosylmethionine-dependent methyltransferase 317032 2895720 KLLA0_F03355g Kluyveromyces lactis S-adenosylmethionine-dependent methyltransferase XP_455232.1 316145 D 28985 CDS KLLA0_F03377g 2895721 complement(317185..318615) F 1 NC_006042.1 similar to uniprot|P41814 Saccharomyces cerevisiae YNL062C GCD10 Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p required for the modification of the adenine at position 58 in tRNAs especially tRNAi-Met first identified as a negative regulator of GCN4 expression; tRNA 1-methyladenosine methyltransferase subunit GCD10 318615 2895721 KLLA0_F03377g Kluyveromyces lactis tRNA 1-methyladenosine methyltransferase subunit GCD10 XP_455233.1 317185 R 28985 CDS KLLA0_F03399g 2895255 319007..320866 F 1 NC_006042.1 similar to uniprot|P40991 Saccharomyces cerevisiae YNL061W NOP2 Probable RNA m(5)C methyltransferase essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis localized to the nucleolus; rRNA (cytosine-C5-)-methyltransferase NOP2 320866 2895255 KLLA0_F03399g Kluyveromyces lactis rRNA (cytosine-C5-)-methyltransferase NOP2 XP_455234.1 319007 D 28985 CDS KLLA0_F03421g 2895256 complement(321000..323243) F 1 NC_006042.1 similar to uniprot|P53946 Saccharomyces cerevisiae YNL059C ARP5 Nuclear actin-related protein involved in chromatin remodeling component of chromatin-remodeling enzyme complexes; uncharacterized protein 323243 2895256 KLLA0_F03421g Kluyveromyces lactis uncharacterized protein XP_455235.1 321000 R 28985 CDS KLLA0_F03443g 2895257 324020..324691 F 1 NC_006042.1 highly similar to uniprot|Q00245 Saccharomyces cerevisiae YIL118W RHO3 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p; Rho family GTPase RHO3 324691 2895257 KLLA0_F03443g Kluyveromyces lactis Rho family GTPase RHO3 XP_455236.1 324020 D 28985 CDS KLLA0_F03465g 2895258 complement(325270..326349) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 326349 2895258 KLLA0_F03465g Kluyveromyces lactis uncharacterized protein XP_455237.1 325270 R 28985 CDS KLLA0_F03487g 2895259 326689..327231 F 1 NC_006042.1 similar to uniprot|P53949 Saccharomyces cerevisiae YNL056W Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; uncharacterized protein 327231 2895259 KLLA0_F03487g Kluyveromyces lactis uncharacterized protein XP_455238.1 326689 D 28985 CDS KLLA0_F03509g 2895260 327598..328761 F 1 NC_006042.1 similar to uniprot|P07172 Saccharomyces cerevisiae YIL116W HIS5 Histidinol-phosphate aminotransferase catalyzes the seventh step in histidine biosynthesis responsive to general control of amino acid biosynthesis mutations cause histidine auxotrophy and sensitivity to Cu Co and Ni salts; histidinol-phosphate transaminase 328761 2895260 KLLA0_F03509g Kluyveromyces lactis histidinol-phosphate transaminase XP_455239.1 327598 D 28985 CDS KLLA0_F03531g 2895261 complement(328830..333227) F 1 NC_006042.1 some similarities with uniprot|P40477 Saccharomyces cerevisiae YIL115C NUP159 Subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side forms a subcomplex with Nup82p and Nsp1p; FG-nucleoporin NUP159 333227 2895261 KLLA0_F03531g Kluyveromyces lactis FG-nucleoporin NUP159 XP_455240.1 328830 R 28985 CDS KLLA0_F03553g 2895262 complement(333841..334689) F 1 NC_006042.1 similar to uniprot|P04840 Saccharomyces cerevisiae YNL055C POR1 Mitochondrial porin (voltage-dependent anion channel) outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; porin POR1 334689 2895262 KLLA0_F03553g Kluyveromyces lactis porin POR1 XP_455241.1 333841 R 28985 CDS KLLA0_F03575g 2895263 337386..340505 F 1 NC_006042.1 weakly similar to uniprot|P53950 Saccharomyces cerevisiae YNL054W VAC7 Integral vacuolar membrane protein may function to regulate Fab1p kinase activity; uncharacterized protein 340505 2895263 KLLA0_F03575g Kluyveromyces lactis uncharacterized protein XP_455242.1 337386 D 28985 CDS KLLA0_F03597g 2895264 341326..342408 F 1 NC_006042.1 similar to uniprot|P38590 Saccharomyces cerevisiae YNL053W MSG5 Dual-specificity protein phosphatase required for maintenance of a low level of signaling through the cell integrity pathway regulates and is regulated by Slt2p also required for adaptive response to pheromone; uncharacterized protein 342408 2895264 KLLA0_F03597g Kluyveromyces lactis uncharacterized protein XP_455243.1 341326 D 28985 CDS KLLA0_F03619g 2895265 342770..345652 F 1 NC_006042.1 similar to uniprot|P40480 Saccharomyces cerevisiae YIL112W HOS4 Subunit of the Set3 complex which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity potential Cdc28p substrate; uncharacterized protein 345652 2895265 KLLA0_F03619g Kluyveromyces lactis uncharacterized protein XP_455244.1 342770 D 28985 CDS KLLA0_F03641g 2895266 join(346255,346760..347211) F 1 NC_006042.1 similar to uniprot|P00425 Saccharomyces cerevisiae YIL111w COX5B or uniprot|P00424 Saccharomyces cerevisiae YNL052w COX5A, subunit Va or Vb of cytochrome c oxidase; uncharacterized protein 347211 2895266 KLLA0_F03641g Kluyveromyces lactis uncharacterized protein XP_455245.1 346255 D 28985 CDS KLLA0_F03663g 2895267 348137..349243 F 1 NC_006042.1 similar to uniprot|P40481 Saccharomyces cerevisiae YIL110W Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; protein-histidine N-methyltransferase 349243 2895267 KLLA0_F03663g Kluyveromyces lactis protein-histidine N-methyltransferase XP_455246.1 348137 D 28985 CDS KLLA0_F03685g 2895268 349421..350593 F 1 NC_006042.1 similar to uniprot|P53951 Saccharomyces cerevisiae YNL051W COG5 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; Golgi transport complex subunit COG5 350593 2895268 KLLA0_F03685g Kluyveromyces lactis Golgi transport complex subunit COG5 XP_455247.1 349421 D 28985 CDS KLLA0_F03707g 2895336 complement(350639..351460) F 1 NC_006042.1 weakly similar to uniprot|P53952 Saccharomyces cerevisiae YNL050C Hypothetical ORF; uncharacterized protein 351460 2895336 KLLA0_F03707g Kluyveromyces lactis uncharacterized protein XP_455248.1 350639 R 28985 CDS KLLA0_F03729g 2895337 complement(351716..354490) F 1 NC_006042.1 similar to uniprot|P40482 Saccharomyces cerevisiae YIL109C SEC24 The Sec23p-Sec24p complex is one of three cytoplamic COPII factors involved in ER to Golgi transport vesicle coat component; uncharacterized protein 354490 2895337 KLLA0_F03729g Kluyveromyces lactis uncharacterized protein XP_455249.1 351716 R 28985 CDS KLLA0_F03751g 2895338 355439..357490 F 1 NC_006042.1 similar to uniprot|P40483 Saccharomyces cerevisiae YIL108W Hypothetical ORF; uncharacterized protein 357490 2895338 KLLA0_F03751g Kluyveromyces lactis uncharacterized protein XP_455250.1 355439 D 28985 CDS KLLA0_F03773g 2895339 complement(357597..359915) F 1 NC_006042.1 similar to uniprot|P40433 Saccharomyces cerevisiae YIL107C PFK26 6-phosphofructo-2-kinase inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate has negligible fructose-2 6-bisphosphatase activity transcriptional regulation involves protein kinase A; 6-phosphofructo-2-kinase 359915 2895339 KLLA0_F03773g Kluyveromyces lactis 6-phosphofructo-2-kinase XP_455251.1 357597 R 28985 CDS KLLA0_F03795g 2895340 join(360687..360706,360840..361737) F 1 NC_006042.1 similar to uniprot|P40484 Saccharomyces cerevisiae YIL106W MOB1 Mps One Binder;(putative) transcriptional regulator involved in mitosis; uncharacterized protein 361737 2895340 KLLA0_F03795g Kluyveromyces lactis uncharacterized protein XP_455252.1 360687 D 28985 CDS KLLA0_F03817g 2895341 362093..363805 F 1 NC_006042.1 similar to uniprot|P53954 Saccharomyces cerevisiae YNL048W ALG11 Alpha-1 2-mannosyltransferase catalyzes addition of the terminal alpha 1 2-Man to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER; alpha-1,2-mannosyltransferase ALG11 363805 2895341 KLLA0_F03817g Kluyveromyces lactis alpha-1,2-mannosyltransferase ALG11 XP_455253.1 362093 D 28985 CDS KLLA0_F03839g 2895342 complement(363977..365923) F 1 NC_006042.1 similar to uniprot|P40485 Saccharomyces cerevisiae YIL105C SLM1 Phosphoinositide PI4 5P(2) binding protein forms a complex with Slm2p acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress phosphorylated by the Tor2p-containing complex TORC2; uncharacterized protein 365923 2895342 KLLA0_F03839g Kluyveromyces lactis uncharacterized protein XP_455254.1 363977 R 28985 CDS KLLA0_F03861g 2895343 367117..367527 F 1 NC_006042.1 no similarity; uncharacterized protein 367527 2895343 KLLA0_F03861g Kluyveromyces lactis uncharacterized protein XP_455255.1 367117 D 28985 CDS KLLA0_F03883g 2895344 368275..370263 F 1 NC_006042.1 similar to uniprot|Q10740 Saccharomyces cerevisiae YNL045W Similar to human LTA4 hydrolase but in vivo substrates not yet defined.; bifunctional aminopeptidase/epoxide hydrolase 370263 2895344 KLLA0_F03883g Kluyveromyces lactis bifunctional aminopeptidase/epoxide hydrolase XP_455256.1 368275 D 28985 CDS KLLA0_F03905g 2895696 join(370581..370604,370776..371282) F 1 NC_006042.1 similar to uniprot|P53633 Saccharomyces cerevisiae YNL044W YIP3 Interacts with YPT proteins; uncharacterized protein 371282 2895696 KLLA0_F03905g Kluyveromyces lactis uncharacterized protein XP_455257.1 370581 D 28985 CDS KLLA0_F03927g 2895697 371730..372767 F 1 NC_006042.1 weakly similar to uniprot|P53958 Saccharomyces cerevisiae YNL042W BOP3 Protein of unknown function potential Cdc28p substrate overproduction suppresses a pam1 slv3 double null mutation; uncharacterized protein 372767 2895697 KLLA0_F03927g Kluyveromyces lactis uncharacterized protein XP_455258.1 371730 D 28985 CDS KLLA0_F03949g 2895698 complement(372819..374246) F 1 NC_006042.1 similar to uniprot|P40486 Saccharomyces cerevisiae YIL104C SHQ1 Essential nuclear protein required for accumulation of box H/ACA snoRNAs and for rRNA processing interacts with Naf1p; Hsp90 cochaperone SHQ1 374246 2895698 KLLA0_F03949g Kluyveromyces lactis Hsp90 cochaperone SHQ1 XP_455259.1 372819 R 28985 CDS KLLA0_F03971g 2895699 374590..375858 F 1 NC_006042.1 highly similar to uniprot|P40487 Saccharomyces cerevisiae YIL103W DPH1 Protein required along with Dph2p Kti11p Jjj3p and Dph5p for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) may act in a complex with Dph2p and Kti11p; 2-(3-amino-3-carboxypropyl)histidine synthase 375858 2895699 KLLA0_F03971g Kluyveromyces lactis 2-(3-amino-3-carboxypropyl)histidine synthase XP_455260.1 374590 D 28985 CDS KLLA0_F03993g 2895700 complement(375915..378254) F 1 NC_006042.1 similar to uniprot|P53959 Saccharomyces cerevisiae YNL041C COG6 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; Golgi transport complex subunit COG6 378254 2895700 KLLA0_F03993g Kluyveromyces lactis Golgi transport complex subunit COG6 XP_455261.1 375915 R 28985 CDS KLLA0_F04015g 2895701 complement(378710..380215) F 1 NC_006042.1 weakly similar to uniprot|P40489 Saccharomyces cerevisiae YIL101C XBP1 Transcriptional repressor that binds to promoter sequences of the cyclin genes CYS3 and SMF2 expression is induced by stress or starvation during mitosis and late in meiosis member of the Swi4p/Mbp1p family potential Cdc28p substrate; uncharacterized protein 380215 2895701 KLLA0_F04015g Kluyveromyces lactis uncharacterized protein XP_455262.1 378710 R 28985 CDS KLLA0_F04037g 2895702 complement(383428..384081) F 1 NC_006042.1 similar to uniprot|P53615 Saccharomyces cerevisiae YNL036W NCE103 Carbonic anhydrase poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions involved in non-classical protein export pathway; carbonate dehydratase NCE103 384081 2895702 KLLA0_F04037g Kluyveromyces lactis carbonate dehydratase NCE103 XP_455263.1 383428 R 28985 CDS KLLA0_F04059g 2895703 385832..387541 F 1 NC_006042.1 similar to uniprot|P08019 Saccharomyces cerevisiae YIL099W SGA1 Intracellular sporulation-specific glucoamylase involved in glycogen degradation induced during starvation of a/a diploids late in sporulation but dispensable for sporulation; glucan 1,4-alpha-glucosidase 387541 2895703 KLLA0_F04059g Kluyveromyces lactis glucan 1,4-alpha-glucosidase XP_455264.1 385832 D 28985 CDS KLLA0_F04081g 2895704 complement(387824..388303) F 1 NC_006042.1 similar to uniprot|P40491 Saccharomyces cerevisiae YIL098C FMC1 Mitochondrial matrix protein required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; uncharacterized protein 388303 2895704 KLLA0_F04081g Kluyveromyces lactis uncharacterized protein XP_455265.1 387824 R 28985 CDS KLLA0_F04103g 2894997 389159..390244 F 1 NC_006042.1 uniprot|O94229 Kluyveromyces lactis KLLA0F04103g IDH1 Isocitrate dehydrogenase subunit 1; isocitrate dehydrogenase (NAD(+)) IDH1 390244 2894997 KLLA0_F04103g Kluyveromyces lactis isocitrate dehydrogenase (NAD(+)) IDH1 XP_455266.1 389159 D 28985 CDS KLLA0_F04125g 2895705 392229..393728 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 393728 2895705 KLLA0_F04125g Kluyveromyces lactis uncharacterized protein XP_455267.1 392229 D 28985 CDS KLLA0_F04169g 2895707 395518..397269 F 1 NC_006042.1 similar to uniprot|P38361 uniprot|P38361 Saccharomyces cerevisiae YBR296C PHO89 Na+/Pi cotransporter active in early growth phase; uncharacterized protein 397269 2895707 KLLA0_F04169g Kluyveromyces lactis uncharacterized protein XP_455268.1 395518 D 28985 CDS KLLA0_F04191g 2895708 397611..400268 F 1 NC_006042.1 similar to uniprot|P19735 Saccharomyces cerevisiae YBR055C PRP6 Splicing factor component of the U4/U6-U5 snRNP complex; U4/U6-U5 snRNP complex subunit PRP6 400268 2895708 KLLA0_F04191g Kluyveromyces lactis U4/U6-U5 snRNP complex subunit PRP6 XP_455269.1 397611 D 28985 CDS KLLA0_F04213g 2894968 400673..402979 F 1 NC_006042.1 similar to uniprot|P40971 Saccharomyces cerevisiae YDR034C LYS14 Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway requires 2-aminoadipate semialdehyde as co-inducer; uncharacterized protein 402979 2894968 KLLA0_F04213g Kluyveromyces lactis uncharacterized protein XP_455270.1 400673 D 28985 CDS KLLA0_F04235g 2894969 complement(403194..404537) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 404537 2894969 KLLA0_F04235g Kluyveromyces lactis uncharacterized protein XP_455271.1 403194 R 28985 CDS KLLA0_F04257g 2894970 complement(404952..406457) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 406457 2894970 KLLA0_F04257g Kluyveromyces lactis uncharacterized protein XP_455272.1 404952 R 28985 CDS KLLA0_F04279g 2894971 407511..408962 F 1 NC_006042.1 some similarities with uniprot|Q05497 Saccharomyces cerevisiae YDR338C Hypothetical ORF; uncharacterized protein 408962 2894971 KLLA0_F04279g Kluyveromyces lactis uncharacterized protein XP_455273.1 407511 D 28985 CDS KLLA0_F04301g 2894972 409431..410447 F 1 NC_006042.1 similar to uniprot|P38235 Saccharomyces cerevisiae YBR053C Hypothetical ORF; uncharacterized protein 410447 2894972 KLLA0_F04301g Kluyveromyces lactis uncharacterized protein XP_455274.1 409431 D 28985 CDS KLLA0_F04323g 2894973 411143..411739 F 1 NC_006042.1 highly similar to uniprot|Q12335 Saccharomyces cerevisiae YDR032C PST2 Protein of unknown function with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; GFP-fusion protein localizes to the cytoplasm in a punctate pattern; uncharacterized protein 411739 2894973 KLLA0_F04323g Kluyveromyces lactis uncharacterized protein XP_455275.1 411143 D 28985 CDS KLLA0_F04345g 2894974 413160..415718 F 1 NC_006042.1 weakly similar to uniprot|Q00816 Saccharomyces cerevisiae YDR028C REG1 Regulatory subunit of type 1 protein phosphatase Glc7p involved in negative regulation of glucose-repressible genes involved in RNA processing; protein phosphatase regulator REG1 415718 2894974 KLLA0_F04345g Kluyveromyces lactis protein phosphatase regulator REG1 XP_455276.1 413160 D 28985 CDS KLLA0_F04367g 2894975 416114..418654 F 1 NC_006042.1 similar to uniprot|Q12071 Saccharomyces cerevisiae YDR027C VPS54 Component of the GARP (Golgi-associated retrograde protein) complex; uncharacterized protein 418654 2894975 KLLA0_F04367g Kluyveromyces lactis uncharacterized protein XP_455277.1 416114 D 28985 CDS KLLA0_F04389g 2895000 419265..421052 F 1 NC_006042.1 uniprot|Q05950 Kluyveromyces lactis KLLA0F04389g REB1 DNA-binding protein REB1; DNA-binding protein REB1 421052 2895000 KLLA0_F04389g Kluyveromyces lactis DNA-binding protein REB1 XP_455278.1 419265 D 28985 CDS KLLA0_F04411g 2895304 complement(421860..422927) F 1 NC_006042.1 no similarity; uncharacterized protein 422927 2895304 KLLA0_F04411g Kluyveromyces lactis uncharacterized protein XP_455279.1 421860 R 28985 CDS KLLA0_F04433g 2894976 complement(424427..425668) F 1 NC_006042.1 some similarities with uniprot|P40472 Saccharomyces cerevisiae YIL123W SIM1 (putative) involved in control of DNA replication; uncharacterized protein 425668 2894976 KLLA0_F04433g Kluyveromyces lactis uncharacterized protein XP_455280.1 424427 R 28985 CDS KLLA0_F04455g 2894977 complement(428010..428927) F 1 NC_006042.1 similar to uniprot|P40471 Saccharomyces cerevisiae YIL124W AYR1 NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles and ER involved in phosphatidic acid biosynthesis and required for spore germination capable of metabolizing mammalian steroid hormones; acylglycerone-phosphate reductase 428927 2894977 KLLA0_F04455g Kluyveromyces lactis acylglycerone-phosphate reductase XP_455281.1 428010 R 28985 CDS KLLA0_F04477g 2894978 complement(429732..432785) F 1 NC_006042.1 highly similar to uniprot|P20967 Saccharomyces cerevisiae YIL125W KGD1 Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex which catalyzes a key step in the tricarboxylic acid (TCA) cycle the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA; alpha-ketoglutarate dehydrogenase KGD1 432785 2894978 KLLA0_F04477g Kluyveromyces lactis alpha-ketoglutarate dehydrogenase KGD1 XP_455282.1 429732 R 28985 CDS KLLA0_F04499g 2894979 complement(434569..435144) F 1 NC_006042.1 highly similar to uniprot|P05738 Saccharomyces cerevisiae uniprot|P05738 Saccharomyces cerevisiae YGL147C RPL9A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins and to YNL067W uniprot|P51401 Saccharomyces cerevisiae YNL067W RPL9B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins; 60S ribosomal protein uL6 435144 2894979 KLLA0_F04499g Kluyveromyces lactis 60S ribosomal protein uL6 XP_455283.1 434569 R 28985 CDS KLLA0_F04521g 2894980 complement(435649..439683) F 1 NC_006042.1 similar to uniprot|P32597 Saccharomyces cerevisiae YIL126W STH1 helicase related protein snf2 homolog; RSC chromatin remodeling complex ATPase subunit STH1 439683 2894980 KLLA0_F04521g Kluyveromyces lactis RSC chromatin remodeling complex ATPase subunit STH1 XP_455284.1 435649 R 28985 CDS KLLA0_F04543g 2894981 440338..440943 F 1 NC_006042.1 similar to uniprot|P40470 Saccharomyces cerevisiae YIL127C Hypothetical ORF; uncharacterized protein 440943 2894981 KLLA0_F04543g Kluyveromyces lactis uncharacterized protein XP_455285.1 440338 D 28985 CDS KLLA0_F04565g 2895894 complement(441106..444195) F 1 NC_006042.1 similar to uniprot|P40469 Saccharomyces cerevisiae YIL128W MET18 DNA repair and TFIIH regulator required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription possible role in assembly of a multiprotein complex(es) required for NER and RNAP II transcription; uncharacterized protein 444195 2895894 KLLA0_F04565g Kluyveromyces lactis uncharacterized protein XP_455286.1 441106 R 28985 CDS KLLA0_F04587g 2895895 444673..451449 F 1 NC_006042.1 similar to uniprot|P40468 Saccharomyces cerevisiae YIL129C TAO3 Identified in a hunt for mutants that activate OCH1 transcription Transcriptional Activator of OCH1; uncharacterized protein 451449 2895895 KLLA0_F04587g Kluyveromyces lactis uncharacterized protein XP_455287.1 444673 D 28985 CDS KLLA0_F04609g 2895896 complement(451579..454329) F 1 NC_006042.1 similar to uniprot|P40467 Saccharomyces cerevisiae YIL130W ASG1 Proposed transcriptional activator member of the Gal4p family of zinc cluster proteins; uncharacterized protein 454329 2895896 KLLA0_F04609g Kluyveromyces lactis uncharacterized protein XP_455288.1 451579 R 28985 CDS KLLA0_F04631g 2895897 455651..457990 F 1 NC_006042.1 similar to uniprot|P40466 Saccharomyces cerevisiae YIL131C FKH1 Transcription factor of the forkhead family that regulates the cell cycle and pseudohyphal growth also involved in chromatin silencing at HML and HMR; forkhead family transcription factor FKH1 457990 2895897 KLLA0_F04631g Kluyveromyces lactis forkhead family transcription factor FKH1 XP_455289.1 455651 D 28985 CDS KLLA0_F04653g 2895898 458393..459034 F 1 NC_006042.1 weakly similar to uniprot|Q45U15 Saccharomyces cerevisiae YIL132C CSM2; uncharacterized protein 459034 2895898 KLLA0_F04653g Kluyveromyces lactis uncharacterized protein XP_455290.1 458393 D 28985 CDS KLLA0_F04675g 2895899 join(459700..459733,460279..460844) F 1 NC_006042.1 highly similar to uniprot|P26784 Saccharomyces cerevisiae YIL133C RPL16A N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5. 8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p and to YNL069C uniprot|P26785 Saccharomyces cerevisiae YNL069C RPL16B N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5. 8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p; 60S ribosomal protein uL13 460844 2895899 KLLA0_F04675g Kluyveromyces lactis 60S ribosomal protein uL13 XP_455291.1 459700 D 28985 CDS KLLA0_F04697g 2895900 complement(461126..462049) F 1 NC_006042.1 similar to uniprot|P40464 Saccharomyces cerevisiae YIL134W FLX1 Protein required for transport of flavin adenine dinucleotide (FAD) from mitochondria where it is synthesized from riboflavin to the cytosol; flavin adenine dinucleotide transporter FLX1 462049 2895900 KLLA0_F04697g Kluyveromyces lactis flavin adenine dinucleotide transporter FLX1 XP_455292.1 461126 R 28985 CDS KLLA0_F04741g 2895917 complement(463107..464528) F 1 NC_006042.1 similar to uniprot|P12695 Saccharomyces cerevisiae YNL071W LAT1 Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA; dihydrolipoyllysine-residue acetyltransferase 464528 2895917 KLLA0_F04741g Kluyveromyces lactis dihydrolipoyllysine-residue acetyltransferase XP_455294.1 463107 R 28985 CDS KLLA0_F04774g 2895919 complement(465362..466276) F 1 NC_006042.1 similar to uniprot|P53942 Saccharomyces cerevisiae YNL072W RNH201 Ribonuclease H2 catalytic subunit removes RNA primers during Okazaki fragment synthesis cooperates with Rad27p nuclease; ribonuclease H2 catalytic subunit RNH201 466276 2895919 KLLA0_F04774g Kluyveromyces lactis ribonuclease H2 catalytic subunit RNH201 XP_455296.1 465362 R 28985 CDS KLLA0_F04796g 2895920 complement(466476..468029) F 1 NC_006042.1 similar to uniprot|P32048 Saccharomyces cerevisiae YNL073W MSK1 Mitochondrial lysine-tRNA synthetase required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria; lysine--tRNA ligase MSK1 468029 2895920 KLLA0_F04796g Kluyveromyces lactis lysine--tRNA ligase MSK1 XP_455297.1 466476 R 28985 CDS KLLA0_F04818g 2895921 469283..470764 F 1 NC_006042.1 similar to uniprot|P20457 Saccharomyces cerevisiae YKL045W PRI2 Subunit of DNA primase which is required for DNA synthesis and double-strand break repair; DNA primase subunit PRI2 470764 2895921 KLLA0_F04818g Kluyveromyces lactis DNA primase subunit PRI2 XP_455298.1 469283 D 28985 CDS KLLA0_F04840g 2895922 474544..476454 F 1 NC_006042.1 some similarities with uniprot|P53438 Saccharomyces cerevisiae YMR016C SOK2 Protein that can when overexpressed suppress mutants of cAMP-dependent protein kinase displays homologies to several transcription factors; uncharacterized protein 476454 2895922 KLLA0_F04840g Kluyveromyces lactis uncharacterized protein XP_455299.1 474544 D 28985 CDS KLLA0_F04862g 2895923 476880..477830 F 1 NC_006042.1 weakly similar to uniprot|P36094 Saccharomyces cerevisiae YKL042W Spindle pole body component SPC42; uncharacterized protein 477830 2895923 KLLA0_F04862g Kluyveromyces lactis uncharacterized protein XP_455300.1 476880 D 28985 CDS KLLA0_F04884g 2895924 complement(478044..481682) F 1 NC_006042.1 highly similar to uniprot|P53622 Saccharomyces cerevisiae YDL145C COP1 Alpha subunit of COPI vesicle coatomer complex which surrounds transport vesicles in the early secretory pathway; coatomer subunit alpha 481682 2895924 KLLA0_F04884g Kluyveromyces lactis coatomer subunit alpha XP_455301.1 478044 R 28985 CDS KLLA0_F04906g 2895925 complement(482183..483673) F 1 NC_006042.1 similar to uniprot|Q05790 Saccharomyces cerevisiae YLR213C; uncharacterized protein 483673 2895925 KLLA0_F04906g Kluyveromyces lactis uncharacterized protein XP_455302.1 482183 R 28985 CDS KLLA0_F04928g 2895926 complement(484158..485249) F 1 NC_006042.1 similar to uniprot|Q07589 Saccharomyces cerevisiae YDL144C Hypothetical ORF; uncharacterized protein 485249 2895926 KLLA0_F04928g Kluyveromyces lactis uncharacterized protein XP_455303.1 484158 R 28985 CDS KLLA0_F04950g 2895927 486258..488345 F 1 NC_006042.1 similar to uniprot|P32791 Saccharomyces cerevisiae YLR214W FRE1 Ferric reductase and cupric reductase reduces siderophore-bound iron and oxidized copper prior to uptake by transporters expression induced by low copper and iron levels; ferric/cupric-chelate reductase 488345 2895927 KLLA0_F04950g Kluyveromyces lactis ferric/cupric-chelate reductase XP_455304.1 486258 D 28985 CDS KLLA0_F04972g 2895928 complement(488863..489963) F 1 NC_006042.1 similar to uniprot|Q05791 Saccharomyces cerevisiae YLR215C CDC123; cell proliferation protein CDC123 489963 2895928 KLLA0_F04972g Kluyveromyces lactis cell proliferation protein CDC123 XP_455305.1 488863 R 28985 CDS KLLA0_F05005g 2895747 490536..492128 F 1 NC_006042.1 highly similar to uniprot|P39078 Saccharomyces cerevisiaeYDL143W CCT4 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p; chaperonin-containing T-complex subunit CCT4 492128 2895747 KLLA0_F05005g Kluyveromyces lactis chaperonin-containing T-complex subunit CCT4 XP_455307.1 490536 D 28985 CDS KLLA0_F05027g 2895748 complement(492389..493285) F 1 NC_006042.1 similar to uniprot|Q07560 Saccharomyces cerevisiae YDL142C CRD1 Cardiolipin synthase produces cardiolipin which is an important constituent of mitochondrial membranes required for normal mitochondrial membrane potential and function; cardiolipin synthase 493285 2895748 KLLA0_F05027g Kluyveromyces lactis cardiolipin synthase XP_455308.1 492389 R 28985 CDS KLLA0_F05049g 2895749 494045..496126 F 1 NC_006042.1 similar to uniprot|P48445 Saccharomyces cerevisiae YDL141W BPL1 Biotin:apoprotein ligase; biotin--[acetyl-CoA-carboxylase] ligase BPL1 496126 2895749 KLLA0_F05049g Kluyveromyces lactis biotin--[acetyl-CoA-carboxylase] ligase BPL1 XP_455309.1 494045 D 28985 CDS KLLA0_F05071g 2895750 complement(496371..501533) F 1 NC_006042.1 highly similar to uniprot|P04050 Saccharomyces cerevisiae YDL140C; DNA-directed RNA polymerase II subunit RPB1 501533 2895750 KLLA0_F05071g Kluyveromyces lactis DNA-directed RNA polymerase II subunit RPB1 XP_455310.1 496371 R 28985 CDS KLLA0_F05093g 2895751 complement(502635..503753) F 1 NC_006042.1 similar to uniprot|P53691 Saccharomyces cerevisiae YLR216C CPR6 Peptidyl-prolyl cis-trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues binds to Hsp82p and contributes to chaperone activity; peptidylprolyl isomerase CPR6 503753 2895751 KLLA0_F05093g Kluyveromyces lactis peptidylprolyl isomerase CPR6 XP_455311.1 502635 R 28985 CDS KLLA0_F05115g 2895752 complement(504092..504694) F 1 NC_006042.1 similar to uniprot|Q12334 Saccharomyces cerevisiae YDL139C SCM3 Suppressor of chromosome missegregation; uncharacterized protein 504694 2895752 KLLA0_F05115g Kluyveromyces lactis uncharacterized protein XP_455312.1 504092 R 28985 CDS KLLA0_F05137g 2895753 complement(504967..505221) F 1 NC_006042.1 similar to uniprot|Q05809 Saccharomyces cerevisiae YLR218C Hypothetical ORF; uncharacterized protein 505221 2895753 KLLA0_F05137g Kluyveromyces lactis uncharacterized protein XP_455313.1 504967 R 28985 CDS KLLA0_F05159g 2895754 506007..509702 F 1 NC_006042.1 similar to uniprot|P38968 Saccharomyces cerevisiae YDL195W SEC31 involved in protein transport from endoplasmic reticulum to Golgi Component (p150) of COPII coat of secretory pathway vesicles; uncharacterized protein 509702 2895754 KLLA0_F05159g Kluyveromyces lactis uncharacterized protein XP_455314.1 506007 D 28985 CDS KLLA0_F05181g 2895755 510384..512747 F 1 NC_006042.1 uniprot|O13477 Kluyveromyces lactis RAG4 Putative glucose sensor; uncharacterized protein 512747 2895755 KLLA0_F05181g Kluyveromyces lactis uncharacterized protein XP_455315.1 510384 D 28985 CDS KLLA0_F05203g 2895756 513318..514319 F 1 NC_006042.1 similar to uniprot|Q12063 Saccharomyces cerevisiae YDL193W NUS1; ditrans,polycis-polyprenyl diphosphate synthase 514319 2895756 KLLA0_F05203g Kluyveromyces lactis ditrans,polycis-polyprenyl diphosphate synthase XP_455316.1 513318 D 28985 CDS KLLA0_F05225g 2895757 515391..515936 F 1 NC_006042.1 highly similar to uniprot|P11076 Saccharomyces cerevisiae YDL192W ARF1 ADP-ribosylation factor GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi functionally interchangeable with Arf2p; uncharacterized protein 515936 2895757 KLLA0_F05225g Kluyveromyces lactis uncharacterized protein XP_455317.1 515391 D 28985 CDS KLLA0_F05247g 2895758 join(517241..517243,517776..518135) F 1 NC_006042.1 highly similar to uniprot|P39741 Saccharomyces cerevisiae YDL191W RPL35A and YDL136W RPL35B, proteins component of the large (60S) ribosomal subunit; 60S ribosomal protein uL29 518135 2895758 KLLA0_F05247g Kluyveromyces lactis 60S ribosomal protein uL29 XP_455318.1 517241 D 28985 CDS KLLA0_F05269g 2895759 complement(518381..521254) F 1 NC_006042.1 similar to uniprot|P54860 Saccharomyces cerevisiae YDL190C UFD2 Ubiquitin chain assembly factor (E4); ubiquitin-ubiquitin ligase UFD2 521254 2895759 KLLA0_F05269g Kluyveromyces lactis ubiquitin-ubiquitin ligase UFD2 XP_455319.1 518381 R 28985 CDS KLLA0_F05291g 2895760 522324..523601 F 1 NC_006042.1 weakly similar to uniprot|Q870H2 Saccharomyces cerevisiae YDL189W RBS1 Protein of unknown function identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization proposed to bind single-stranded nucleic acids via its R3H domain; uncharacterized protein 523601 2895760 KLLA0_F05291g Kluyveromyces lactis uncharacterized protein XP_455320.1 522324 D 28985 CDS KLLA0_F05313g 2895735 complement(523845..524444) F 1 NC_006042.1 highly similar to uniprot|Q12434 Saccharomyces cerevisiae YDL135C RDI1 Rho GDP dissociation inhibitor; uncharacterized protein 524444 2895735 KLLA0_F05313g Kluyveromyces lactis uncharacterized protein XP_455321.1 523845 R 28985 CDS KLLA0_F05335g 2895736 524979..525563 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 525563 2895736 KLLA0_F05335g Kluyveromyces lactis uncharacterized protein XP_455322.1 524979 D 28985 CDS KLLA0_F05357g 2895737 complement(525923..527005) F 1 NC_006042.1 highly similar to uniprot|P23594 Saccharomyces cerevisiae YDL134C PPH21 Catalytic subunit of protein phosphatase 2A functionally redundant with Pph22p methylated at C terminus forms alternate complexes with several regulatory subunits involved in signal transduction and regulation of mitosis; uncharacterized protein 527005 2895737 KLLA0_F05357g Kluyveromyces lactis uncharacterized protein XP_455323.1 525923 R 28985 CDS KLLA0_F05379g 2895738 527893..528615 F 1 NC_006042.1 some similarities with uniprot|P48568 Saccharomyces cerevisiae YDL186W Hypothetical ORF; uncharacterized protein 528615 2895738 KLLA0_F05379g Kluyveromyces lactis uncharacterized protein XP_455324.1 527893 D 28985 CDS KLLA0_F05401g 2895739 529272..532355 F 1 NC_006042.1 highly similar to uniprot|P17255 Saccharomyces cerevisiae YDL185W TFP1 Vacuolar ATPase V1 domain subunit A protein precursor is spliced to yield the extein Tfp1p and the intein Vde (PI-SceI) which is a site-specific endonuclease; H(+)-transporting V1 sector ATPase subunit A 532355 2895739 KLLA0_F05401g Kluyveromyces lactis H(+)-transporting V1 sector ATPase subunit A XP_455325.1 529272 D 28985 CDS KLLA0_F05423g 2895740 complement(533977..534867) F 1 NC_006042.1 similar to uniprot|P48569 Saccharomyces cerevisiae YDL183C Hypothetical ORF; uncharacterized protein 534867 2895740 KLLA0_F05423g Kluyveromyces lactis uncharacterized protein XP_455326.1 533977 R 28985 CDS KLLA0_F05445g 2895741 535675..537105 F 1 NC_006042.1 weakly similar to uniprot|Q12516 Saccharomyces cerevisiae YDL133W; uncharacterized protein 537105 2895741 KLLA0_F05445g Kluyveromyces lactis uncharacterized protein XP_455327.1 535675 D 28985 CDS KLLA0_F05467g 2895742 537921..540359 F 1 NC_006042.1 similar to uniprot|Q12018 Saccharomyces cerevisiae YDL132W CDC53 Cullin structural protein of SCF complexes (which also contain Skp1p Cdc34p and an F-box protein) involved in ubiquitination SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation; cullin CDC53 540359 2895742 KLLA0_F05467g Kluyveromyces lactis cullin CDC53 XP_455328.1 537921 D 28985 CDS KLLA0_F05489g 2895743 541146..542471 F 1 NC_006042.1 highly similar to uniprot|Q12122 Saccharomyces cerevisiae YDL131W LYS21 and to uniprot|P48570 Saccharomyces cerevisiae YDL182W LYS20 homocitrate synthase; homocitrate synthase LYS21 542471 2895743 KLLA0_F05489g Kluyveromyces lactis homocitrate synthase LYS21 XP_455329.1 541146 D 28985 CDS KLLA0_F05511g 2895744 543219..543488 F 1 NC_006042.1 weakly similar to uniprot|P01097 Saccharomyces cerevisiae YDL181W INH1 Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p has similarity to Stf1p and both Inh1p and Stf1p exhibit the potential to form coiled-coil structures; ATPase-binding protein 543488 2895744 KLLA0_F05511g Kluyveromyces lactis ATPase-binding protein XP_455330.1 543219 D 28985 CDS KLLA0_F05555g 2895746 544997..545311 F 1 NC_006042.1 highly similar to uniprot|P10622 Saccharomyces cerevisiae YDL130W RPP1B Ribosomal protein P1 beta a component of the ribosomal stalk which is involved in the interaction between translational elongation factors and the ribosome accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component; ribosomal protein P1 beta 545311 2895746 KLLA0_F05555g Kluyveromyces lactis ribosomal protein P1 beta XP_455332.1 544997 D 28985 CDS KLLA0_F05588g 2895306 546398..547198 F 1 NC_006042.1 weakly similar to uniprot|Q07555 Saccharomyces cerevisiae YDL129W Hypothetical ORF; uncharacterized protein 547198 2895306 KLLA0_F05588g Kluyveromyces lactis uncharacterized protein XP_455333.1 546398 D 28985 CDS KLLA0_F05610g 2895307 548033..549529 F 1 NC_006042.1 similar to uniprot|Q12301 Saccharomyces cerevisiae YDL180W Hypothetical ORF; uncharacterized protein 549529 2895307 KLLA0_F05610g Kluyveromyces lactis uncharacterized protein XP_455334.1 548033 D 28985 CDS KLLA0_F05632g 2895308 550145..551365 F 1 NC_006042.1 similar to uniprot|O13581 Saccharomyces cerevisiae YDL128W; uncharacterized protein 551365 2895308 KLLA0_F05632g Kluyveromyces lactis uncharacterized protein XP_455335.1 550145 D 28985 CDS KLLA0_F05654g 2895309 552056..552991 F 1 NC_006042.1 weakly similar to uniprot|P25693 Saccharomyces cerevisiae YDL127W PCL2 G1 cyclin associates with Pho85p cyclin-dependent kinase (Cdk) to contribute to entry into the mitotic cell cycle essential for cell morphogenesis localizes to sites of polarized cell growth; cyclin PCL2 552991 2895309 KLLA0_F05654g Kluyveromyces lactis cyclin PCL2 XP_455336.1 552056 D 28985 CDS KLLA0_F05676g 2895310 complement(553406..555898) F 1 NC_006042.1 highly similar to uniprot|P25694 Saccharomyces cerevisiae YDL126C CDC48 ATPase in ER nuclear membrane and cytosol with homology to mammalian p97 in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome; AAA family ATPase CDC48 555898 2895310 KLLA0_F05676g Kluyveromyces lactis AAA family ATPase CDC48 XP_455337.1 553406 R 28985 CDS KLLA0_F05731g 2895313 complement(join(556540..556934,557083..557134)) F 1 NC_006042.1 highly similar to uniprot|Q04344 Saccharomyces cerevisiae YDL125C; adenosine 5'-monophosphoramidase 557134 2895313 KLLA0_F05731g Kluyveromyces lactis adenosine 5'-monophosphoramidase XP_455340.1 556540 R 28985 CDS KLLA0_F05753g 2895314 558009..559640 F 1 NC_006042.1 highly similar to uniprot|P46681 Saccharomyces cerevisiae YDL178W DLD2 D-lactate dehydrogenase located in the mitochondrial matrix; D-lactate dehydrogenase 559640 2895314 KLLA0_F05753g Kluyveromyces lactis D-lactate dehydrogenase XP_455341.1 558009 D 28985 CDS KLLA0_F05775g 2895315 560270..561199 F 1 NC_006042.1 highly similar to uniprot|Q07551 Saccharomyces cerevisiae YDL124W NADPH-dependent alpha-keto amide reductase reduces aromatic alpha-keto amides aliphatic alpha-keto esters and aromatic alpha-keto esters; aldo-keto reductase superfamily protein 561199 2895315 KLLA0_F05775g Kluyveromyces lactis aldo-keto reductase superfamily protein XP_455342.1 560270 D 28985 CDS KLLA0_F05797g 2895269 complement(561393..561914) F 1 NC_006042.1 similar to uniprot|Q12257 Saccharomyces cerevisiae YDL177C Hypothetical ORF; uncharacterized protein 561914 2895269 KLLA0_F05797g Kluyveromyces lactis uncharacterized protein XP_455343.1 561393 R 28985 CDS KLLA0_F05819g 2895270 562259..564289 F 1 NC_006042.1 similar to uniprot|Q12027 Saccharomyces cerevisiae YDL176W Hypothetical ORF; uncharacterized protein 564289 2895270 KLLA0_F05819g Kluyveromyces lactis uncharacterized protein XP_455344.1 562259 D 28985 CDS KLLA0_F05841g 2895271 complement(564453..564866) F 1 NC_006042.1 similar to uniprot|Q07549 Saccharomyces cerevisiae YDL123W SNA4 Protein of unknown function localized to the vacuolar outer membrane; uncharacterized protein 564866 2895271 KLLA0_F05841g Kluyveromyces lactis uncharacterized protein XP_455345.1 564453 R 28985 CDS KLLA0_F05896g 2895274 complement(566005..567054) F 1 NC_006042.1 similar to uniprot|P40507 Saccharomyces cerevisiae and similar to uniprot|Q12476 Saccharomyces cerevisiae YDL175C AIR2 RING finger proteins; uncharacterized protein 567054 2895274 KLLA0_F05896g Kluyveromyces lactis uncharacterized protein XP_455347.1 566005 R 28985 CDS KLLA0_F05918g 2895275 567803..570037 F 1 NC_006042.1 highly similar to uniprot|P04801 Saccharomyces cerevisiae YIL078W THS1 Threonyl-tRNA synthetase cytoplasmic; threonine--tRNA ligase THS1 570037 2895275 KLLA0_F05918g Kluyveromyces lactis threonine--tRNA ligase THS1 XP_455348.1 567803 D 28985 CDS KLLA0_F05940g 2895276 complement(570437..571330) F 1 NC_006042.1 weakly similar to uniprot|P40508 Saccharomyces cerevisiae YIL077C Hypothetical ORF; uncharacterized protein 571330 2895276 KLLA0_F05940g Kluyveromyces lactis uncharacterized protein XP_455349.1 570437 R 28985 CDS KLLA0_F05962g 2895277 571896..572699 F 1 NC_006042.1 highly similar to uniprot|P25627 Saccharomyces cerevisiae YCR047C BUD23 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; 18S rRNA (guanine1575-N7)-methyltransferase 572699 2895277 KLLA0_F05962g Kluyveromyces lactis 18S rRNA (guanine1575-N7)-methyltransferase XP_455350.1 571896 D 28985 CDS KLLA0_F05984g 2895278 573009..573524 F 1 NC_006042.1 similar to uniprot|P25626 Saccharomyces cerevisiae YCR046C IMG1 Mitochondrial ribosomal protein of the small subunit required for respiration and for maintenance of the mitochondrial genome; mitochondrial 54S ribosomal protein bL19m 573524 2895278 KLLA0_F05984g Kluyveromyces lactis mitochondrial 54S ribosomal protein bL19m XP_455351.1 573009 D 28985 CDS KLLA0_F06006g 2895279 complement(574421..575086) F 1 NC_006042.1 similar to uniprot|P53721 Saccharomyces cerevisiae YNR018W Hypothetical ORF; uncharacterized protein 575086 2895279 KLLA0_F06006g Kluyveromyces lactis uncharacterized protein XP_455352.1 574421 R 28985 CDS KLLA0_F06028g 2895280 576687..578213 F 1 NC_006042.1 some similarities with uniprot|P25036 Saccharomyces cerevisiae YOR003W YSP3 subtilisin-like protease III; uncharacterized protein 578213 2895280 KLLA0_F06028g Kluyveromyces lactis uncharacterized protein XP_455353.1 576687 D 28985 CDS KLLA0_F06050g 2895281 complement(578912..579571) F 1 NC_006042.1 similar to uniprot|P32897 Saccharomyces cerevisiae YNR017W MAS6 Essential protein of the mitochondrial inner membrane component of the mitochondrial import system; protein transporter TIM23 579571 2895281 KLLA0_F06050g Kluyveromyces lactis protein transporter TIM23 XP_455354.1 578912 R 28985 CDS KLLA0_F06061g 9487364 580713..580970 F 1 NC_006042.1 no similarity; uncharacterized protein 580970 9487364 KLLA0_F06061g Kluyveromyces lactis uncharacterized protein XP_002999426.1 580713 D 28985 CDS KLLA0_F06072g 2895282 583276..589971 F 1 NC_006042.1 highly similar to uniprot|Q00955 Saccharomyces cerevisiae YNR016C ACC1 Acetyl-CoA carboxylase biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA required for de novo biosynthesis of long-chain fatty acids; acetyl-CoA carboxylase ACC1 589971 2895282 KLLA0_F06072g Kluyveromyces lactis acetyl-CoA carboxylase ACC1 XP_455355.1 583276 D 28985 CDS KLLA0_F06094g 2895019 complement(590298..591377) F 1 NC_006042.1 similar to uniprot|P53720 Saccharomyces cerevisiae YNR015W SMM1 tRNA dihydrouridine synthase; tRNA-dihydrouridine(20) synthase (NAD(+)) 591377 2895019 KLLA0_F06094g Kluyveromyces lactis tRNA-dihydrouridine(20) synthase (NAD(+)) XP_455356.1 590298 R 28985 CDS KLLA0_F06116g 2895020 592103..595960 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 595960 2895020 KLLA0_F06116g Kluyveromyces lactis uncharacterized protein XP_455357.1 592103 D 28985 CDS KLLA0_F06138g 2895021 complement(596318..597241) F 1 NC_006042.1 some similarities with uniprot|Q03695 Saccharomyces cerevisiae YMR206W Hypothetical ORF; uncharacterized protein 597241 2895021 KLLA0_F06138g Kluyveromyces lactis uncharacterized protein XP_455358.1 596318 R 28985 CDS KLLA0_F06160g 2895022 598549..601128 F 1 NC_006042.1 similar to uniprot|P27514 Saccharomyces cerevisiae YNR013C PHO91 Low-affinity phosphate transporter deletion of pho84 pho87 pho89 pho90 and pho91 causes synthetic lethality transcription independent of Pi and Pho4p activity overexpression results in vigorous growth; uncharacterized protein 601128 2895022 KLLA0_F06160g Kluyveromyces lactis uncharacterized protein XP_455359.1 598549 D 28985 CDS KLLA0_F06182g 2895023 complement(601351..602730) F 1 NC_006042.1 similar to uniprot|P27515 Saccharomyces cerevisiae YNR012W URK1 converts ATP and uridine to ADP and UMP Uridine kinase; uridine kinase URK1 602730 2895023 KLLA0_F06182g Kluyveromyces lactis uridine kinase URK1 XP_455360.1 601351 R 28985 CDS KLLA0_F06204g 2895024 602989..605622 F 1 NC_006042.1 similar to uniprot|P20095 Saccharomyces cerevisiae YNR011C PRP2 RNA-dependent ATPase in the DEAH-box family required for activation of the spliceosome before the first transesterification step in RNA splicing; DEAH-box RNA-dependent ATPase PRP2 605622 2895024 KLLA0_F06204g Kluyveromyces lactis DEAH-box RNA-dependent ATPase PRP2 XP_455361.1 602989 D 28985 CDS KLLA0_F06226g 2895025 606977..607993 F 1 NC_006042.1 similar to uniprot|P50107 Saccharomyces cerevisiae YML004C GLO1 Monomeric glyoxalase I catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione expression regulated by methylglyoxal levels and osmotic stress; lactoylglutathione lyase GLO1 607993 2895025 KLLA0_F06226g Kluyveromyces lactis lactoylglutathione lyase GLO1 XP_455362.1 606977 D 28985 CDS KLLA0_F06248g 2894998 608680..611496 F 1 NC_006042.1 uniprot|Q03216 Kluyveromyces lactis KLLA0F06248g PFK2 6- phosphofructokinase subunit beta; 6-phosphofructokinase subunit beta 611496 2894998 KLLA0_F06248g Kluyveromyces lactis 6-phosphofructokinase subunit beta XP_455363.1 608680 D 28985 CDS KLLA0_F06270g 2895026 611896..612927 F 1 NC_006042.1 some similarities with uniprot|Q03694 Saccharomyces cerevisiae YMR204C Hypothetical ORF; uncharacterized protein 612927 2895026 KLLA0_F06270g Kluyveromyces lactis uncharacterized protein XP_455364.1 611896 D 28985 CDS KLLA0_F06292g 2895027 complement(613470..614633) F 1 NC_006042.1 highly similar to uniprot|P23644 Saccharomyces cerevisiae YMR203W TOM40 Essential component of the preprotein translocase of the mitochondrial outer membrane (TOM complex) in which it constitutes the core element of the protein conducting pore; uncharacterized protein 614633 2895027 KLLA0_F06292g Kluyveromyces lactis uncharacterized protein XP_455365.1 613470 R 28985 CDS KLLA0_F06314g 2895028 complement(615122..615493) F 1 NC_006042.1 similar to uniprot|P33308 Saccharomyces cerevisiae YNR010W CSE2 Component of the Med9/10 module which is a subcomplex within the RNA polymerase II Mediator complex required for regulation of RNA polymerase II activity; uncharacterized protein 615493 2895028 KLLA0_F06314g Kluyveromyces lactis uncharacterized protein XP_455366.1 615122 R 28985 CDS KLLA0_F06336g 2895029 complement(615776..616447) F 1 NC_006042.1 highly similar to uniprot|P32352 Saccharomyces cerevisiae YMR202W ERG2 C-8 sterol isomerase catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis; C-8 sterol isomerase ERG2 616447 2895029 KLLA0_F06336g Kluyveromyces lactis C-8 sterol isomerase ERG2 XP_455367.1 615776 R 28985 CDS KLLA0_F06358g 2895030 complement(616922..617587) F 1 NC_006042.1 weakly similar to YNR009w; uncharacterized protein 617587 2895030 KLLA0_F06358g Kluyveromyces lactis uncharacterized protein XP_455368.1 616922 R 28985 CDS KLLA0_F06380g 2895031 complement(618296..620266) F 1 NC_006042.1 similar to uniprot|P40345 Saccharomyces cerevisiae YNR008W LRO1 Acyltransferase that catalyzes diacylglycerol esterification one of several acyltransferases that contribute to triglyceride synthesis putative homolog of human lecithin cholesterol acyltransferase; phospholipid:diacylglycerol acyltransferase 620266 2895031 KLLA0_F06380g Kluyveromyces lactis phospholipid:diacylglycerol acyltransferase XP_455369.1 618296 R 28985 CDS KLLA0_F06402g 2895032 621021..621929 F 1 NC_006042.1 similar to uniprot|P40344 Saccharomyces cerevisiae YNR007C ATG3 Protein involved in autophagy E2-like enzyme that plays a role in formation of Atg8p-phosphatidylethanolamine conjugates which are involved in membrane dynamics during autophagy; uncharacterized protein 621929 2895032 KLLA0_F06402g Kluyveromyces lactis uncharacterized protein XP_455370.1 621021 D 28985 CDS KLLA0_F06424g 2895033 join(622190..622225,622299..623333) F 1 NC_006042.1 similar to uniprot|P28519 Saccharomyces cerevisiae YMR201C RAD14 Protein that recognizes and binds damaged DNA during nucleotide excision repair subunit of Nucleotide Excision Repair Factor 1 (NEF1) contains zinc finger motif homolog of human XPA protein; DNA repair protein RAD14 623333 2895033 KLLA0_F06424g Kluyveromyces lactis DNA repair protein RAD14 XP_455371.2 622190 D 28985 CDS KLLA0_F06446g 2895034 complement(623443..625254) F 1 NC_006042.1 similar to uniprot|P40343 Saccharomyces cerevisiae YNR006W VPS27 hydrophilic protein has cysteine rich putative zinc finger esential for function; ESCRT-0 subunit protein VPS27 625254 2895034 KLLA0_F06446g Kluyveromyces lactis ESCRT-0 subunit protein VPS27 XP_455372.1 623443 R 28985 CDS KLLA0_F06468g 2895035 complement(625692..626417) F 1 NC_006042.1 similar to uniprot|Q03691 Saccharomyces cerevisiae YMR200W ROT1 Protein that may be involved in cell wall function mutations in rot1 cause cell wall defects suppress tor2 mutations and are synthetically lethal with rot2 mutations; uncharacterized protein 626417 2895035 KLLA0_F06468g Kluyveromyces lactis uncharacterized protein XP_455373.1 625692 R 28985 CDS KLLA0_F06490g 2895036 complement(626983..628569) F 1 NC_006042.1 similar to uniprot|P20437 Saccharomyces cerevisiae YMR199W CLN1 role in cell cycle START G(sub)1 cyclin; cyclin CLN1 628569 2895036 KLLA0_F06490g Kluyveromyces lactis cyclin CLN1 XP_455374.1 626983 R 28985 CDS KLLA0_F06512g 2895037 complement(629870..630685) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 630685 2895037 KLLA0_F06512g Kluyveromyces lactis uncharacterized protein XP_455375.1 629870 R 28985 CDS KLLA0_F06534g 2895038 631051..632247 F 1 NC_006042.1 weakly similar to uniprot|Q12365 Saccharomyces cerevisiae YPL255W BBP1 Protein required for the spindle pole body (SPB) duplication localized at the central plaque periphery forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p required for mitotic functions of Cdc5p; uncharacterized protein 632247 2895038 KLLA0_F06534g Kluyveromyces lactis uncharacterized protein XP_455376.1 631051 D 28985 CDS KLLA0_F06556g 2895039 633167..634261 F 1 NC_006042.1 highly similar to uniprot|P32449 Saccharomyces cerevisiae YBR249C ARO4 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; 3-deoxy-7-phosphoheptulonate synthase ARO4 634261 2895039 KLLA0_F06556g Kluyveromyces lactis 3-deoxy-7-phosphoheptulonate synthase ARO4 XP_455377.1 633167 D 28985 CDS KLLA0_F06578g 2895040 634720..636378 F 1 NC_006042.1 highly similar to uniprot|P33734 Saccharomyces cerevisiae YBR248C HIS7 Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase) catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR) a purine precursor; imidazoleglycerol-phosphate synthase 636378 2895040 KLLA0_F06578g Kluyveromyces lactis imidazoleglycerol-phosphate synthase XP_455378.1 634720 D 28985 CDS KLLA0_F06600g 2895041 complement(636501..637943) F 1 NC_006042.1 similar to uniprot|P21827 Saccharomyces cerevisiae YGL097W SRM1 Nucleotide exchange factor for Gsp1p localizes to the nucleus required for nucleocytoplasmic trafficking of macromolecules potentially phosphorylated by Cdc28p; Ran guanyl-nucleotide exchange factor 637943 2895041 KLLA0_F06600g Kluyveromyces lactis Ran guanyl-nucleotide exchange factor XP_455379.1 636501 R 28985 CDS KLLA0_F06622g 2894767 638611..640047 F 1 NC_006042.1 similar to uniprot|P38333 Saccharomyces cerevisiae YBR247C ENP1 Protein associated with U3 and U14 snoRNAs required for pre-rRNA processing and 40S ribosomal subunit synthesis localized in the nucleus and concentrated in the nucleolus; snoRNA-binding rRNA-processing protein ENP1 640047 2894767 KLLA0_F06622g Kluyveromyces lactis snoRNA-binding rRNA-processing protein ENP1 XP_455380.1 638611 D 28985 CDS KLLA0_F06644g 2894768 complement(640261..641043) F 1 NC_006042.1 similar to uniprot|P53146 Saccharomyces cerevisiae YGL098W USE1 Use1p is a SNARE and forms a complex with the SNAREs Sec22p Sec20p and Ufe1p. The protein is localized to the ER and use1 mutants show defects in retrograde traffic from the Golgi to the ER Protein required for cell viability; SNAP receptor USE1 641043 2894768 KLLA0_F06644g Kluyveromyces lactis SNAP receptor USE1 XP_455381.1 640261 R 28985 CDS KLLA0_F06666g 2894769 complement(641931..643877) F 1 NC_006042.1 highly similar to uniprot|P53145 Saccharomyces cerevisiae YGL099W LSG1 Putative GTPase involved in 60S ribosomal subunit biogenesis localized to the cytoplasm; uncharacterized protein 643877 2894769 KLLA0_F06666g Kluyveromyces lactis uncharacterized protein XP_455382.1 641931 R 28985 CDS KLLA0_F06688g 2894770 644040..645299 F 1 NC_006042.1 similar to uniprot|P38332 Saccharomyces cerevisiae YBR246W Hypothetical ORF; diphthamide synthase 645299 2894770 KLLA0_F06688g Kluyveromyces lactis diphthamide synthase XP_455383.1 644040 D 28985 CDS KLLA0_F06710g 2894771 645650..648940 F 1 NC_006042.1 similar to uniprot|P38144 Saccharomyces cerevisiae YBR245C ISW1 Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation and a complex with Ioc3p to repress transcription initiation; chromatin-remodeling ATPase ISW1 648940 2894771 KLLA0_F06710g Kluyveromyces lactis chromatin-remodeling ATPase ISW1 XP_455384.1 645650 D 28985 CDS KLLA0_F06732g 2894772 complement(649269..649754) F 1 NC_006042.1 highly similar to uniprot|P40581 Saccharomyces cerevisiae YIR037W HYR1 Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor; glutathione peroxidase GPX2 649754 2894772 KLLA0_F06732g Kluyveromyces lactis glutathione peroxidase GPX2 XP_455385.1 649269 R 28985 CDS KLLA0_F06754g 2894773 complement(650475..651509) F 1 NC_006042.1 similar to uniprot|P53011 Saccharomyces cerevisiae YGL100W SEH1 Nuclear pore protein homologous to Sec13p; uncharacterized protein 651509 2894773 KLLA0_F06754g Kluyveromyces lactis uncharacterized protein XP_455386.1 650475 R 28985 CDS KLLA0_F06776g 2894774 651801..653144 F 1 NC_006042.1 similar to uniprot|P07286 Saccharomyces cerevisiae YBR243C ALG7 UDP-N-acetyl-glucosamine-1-P transferase transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation inhibited by tunicamycin; UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 653144 2894774 KLLA0_F06776g Kluyveromyces lactis UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase XP_455387.1 651801 D 28985 CDS KLLA0_F06798g 2894775 complement(653398..654159) F 1 NC_006042.1 similar to uniprot|P38331 Saccharomyces cerevisiae YBR242W Hypothetical ORF or YGL101W uniprot|P53144 Saccharomyces cerevisiae YGL101W Hypothetical ORF; uncharacterized protein 654159 2894775 KLLA0_F06798g Kluyveromyces lactis uncharacterized protein XP_455388.1 653398 R 28985 CDS KLLA0_F06831g 2894777 complement(join(654656..655056,655801..655849)) F 1 NC_006042.1 uniprot|Q8J287 Kluyveromyces lactis RPL28 protein; 60S ribosomal protein uL15 655849 2894777 KLLA0_F06831g Kluyveromyces lactis 60S ribosomal protein uL15 XP_455390.1 654656 R 28985 CDS KLLA0_F06853g 2894778 656373..657959 F 1 NC_006042.1 similar to uniprot|P38142 Saccharomyces cerevisiae YBR241C Hypothetical ORF; uncharacterized protein 657959 2894778 KLLA0_F06853g Kluyveromyces lactis uncharacterized protein XP_455391.1 656373 D 28985 CDS KLLA0_F06875g 2895682 complement(658475..658900) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 658900 2895682 KLLA0_F06875g Kluyveromyces lactis uncharacterized protein XP_455392.1 658475 R 28985 CDS KLLA0_F06897g 2895683 659764..661596 F 1 NC_006042.1 similar to uniprot|P53735 Saccharomyces cerevisiae YNR039C ZRG17 Endoplasmic reticulum protein of unknown function transcription is induced under conditions of zinc deficiency mutant phenotype suggests a role in uptake of zinc; Zn(2+) transporter ZRG17 661596 2895683 KLLA0_F06897g Kluyveromyces lactis Zn(2+) transporter ZRG17 XP_455393.1 659764 D 28985 CDS KLLA0_F06919g 2895684 complement(661670..665638) F 1 NC_006042.1 similar to uniprot|P25648 Saccharomyces cerevisiae YCR081W SRB8 RNA polymerase II mediator complex subunit; uncharacterized protein 665638 2895684 KLLA0_F06919g Kluyveromyces lactis uncharacterized protein XP_455394.1 661670 R 28985 CDS KLLA0_F06941g 2895685 complement(665970..667862) F 1 NC_006042.1 similar to uniprot|P53734 Saccharomyces cerevisiae YNR038W DBP6 Essential protein involved in ribosome biogenesis, putative ATP-dependent RNA helicase of the DEAD-box protein family; uncharacterized protein 667862 2895685 KLLA0_F06941g Kluyveromyces lactis uncharacterized protein XP_455395.1 665970 R 28985 CDS KLLA0_F06963g 2895686 668130..668405 F 1 NC_006042.1 highly similar to uniprot|P53733 Saccharomyces cerevisiae YNR037C; mitochondrial 37S ribosomal protein uS19m 668405 2895686 KLLA0_F06963g Kluyveromyces lactis mitochondrial 37S ribosomal protein uS19m XP_455396.1 668130 D 28985 CDS KLLA0_F06985g 2895687 complement(668701..670158) F 1 NC_006042.1 similar to uniprot|P25646 Saccharomyces cerevisiae YCR079W Hypothetical ORF; type 2C protein phosphatase PTC6 670158 2895687 KLLA0_F06985g Kluyveromyces lactis type 2C protein phosphatase PTC6 XP_455397.1 668701 R 28985 CDS KLLA0_F07007g 2895688 671210..671713 F 1 NC_006042.1 highly similar to uniprot|P53732 Saccharomyces cerevisiae YNR036C; mitochondrial 37S ribosomal protein uS12m 671713 2895688 KLLA0_F07007g Kluyveromyces lactis mitochondrial 37S ribosomal protein uS12m XP_455398.1 671210 D 28985 CDS KLLA0_F07029g 2895689 672114..673094 F 1 NC_006042.1 similar to uniprot|P53731 Saccharomyces cerevisiae YNR035C ARC35 Subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches required for cortical localization of calmodulin; uncharacterized protein 673094 2895689 KLLA0_F07029g Kluyveromyces lactis uncharacterized protein XP_455399.1 672114 D 28985 CDS KLLA0_F07073g 2895691 675221..676897 F 1 NC_006042.1 some similarities with uniprot|Q7LH06 Saccharomyces cerevisiae YDL048C STP4 Protein involved in pre-tRNA splicing and in uptake of branched-chain amino acids; uncharacterized protein 676897 2895691 KLLA0_F07073g Kluyveromyces lactis uncharacterized protein XP_455401.1 675221 D 28985 CDS KLLA0_F07095g 2895692 complement(677773..679005) F 1 NC_006042.1 highly similar to uniprot|Q765N3 Saccharomyces kluyveri Sk Delta 12-fatty acid desaturase; uncharacterized protein 679005 2895692 KLLA0_F07095g Kluyveromyces lactis uncharacterized protein XP_455402.1 677773 R 28985 CDS KLLA0_F07117g 2895693 680589..681044 F 1 NC_006042.1 weakly similar to uniprot|P38985 Saccharomyces cerevisiae YDL092W SRP14 Signal recognition particle subunit; RNA-binding signal recognition particle subunit SRP14 681044 2895693 KLLA0_F07117g Kluyveromyces lactis RNA-binding signal recognition particle subunit SRP14 XP_455403.1 680589 D 28985 CDS KLLA0_F07139g 2895694 complement(681163..682401) F 1 NC_006042.1 similar to uniprot|Q12229 YDL091c Saccharomyces cerevisiae UBX3 UBX domain-containing protein that interacts with Cdc48p; uncharacterized protein 682401 2895694 KLLA0_F07139g Kluyveromyces lactis uncharacterized protein XP_455404.1 681163 R 28985 CDS KLLA0_F07161g 2895695 complement(682786..684075) F 1 NC_006042.1 similar to uniprot|P22007 Saccharomyces cerevisiae YDL090C RAM1 essential for processing of ras proteins beta subunit of farnesyltransferase; protein farnesyltransferase 684075 2895695 KLLA0_F07161g Kluyveromyces lactis protein farnesyltransferase XP_455405.1 682786 R 28985 CDS KLLA0_F07183g 2895973 684265..686322 F 1 NC_006042.1 weakly similar to uniprot|Q03792 Saccharomyces cerevisiae YMR154C; uncharacterized protein 686322 2895973 KLLA0_F07183g Kluyveromyces lactis uncharacterized protein XP_455406.1 684265 D 28985 CDS KLLA0_F07205g 2895974 686532..688172 F 1 NC_006042.1 weakly similar to uniprot|Q12066 Saccharomyces cerevisiae YDL089W Protein of unknown function interacts with meiotic division protein Csm1p green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery potential Cdc28p substrate; uncharacterized protein 688172 2895974 KLLA0_F07205g Kluyveromyces lactis uncharacterized protein XP_455407.1 686532 D 28985 CDS KLLA0_F07227g 2895975 complement(688282..689526) F 1 NC_006042.1 some similarities with uniprot|Q05166 Saccharomyces cerevisiae YDL088C ASM4 Nuclear pore complex subunit part of a subcomplex also containing Nup53p Nup170p and Pse1p; FG-nucleoporin ASM4 689526 2895975 KLLA0_F07227g Kluyveromyces lactis FG-nucleoporin ASM4 XP_455408.1 688282 R 28985 CDS KLLA0_F07249g 2895976 complement(689786..690556) F 1 NC_006042.1 similar to uniprot|Q07508 Saccharomyces cerevisiae YDL087C LUC7 Essential protein associated with the U1 snRNP complex splicing factor involved in recognition of 5' splice site; uncharacterized protein 690556 2895976 KLLA0_F07249g Kluyveromyces lactis uncharacterized protein XP_455409.1 689786 R 28985 CDS KLLA0_F07271g 2895977 690795..691490 F 1 NC_006042.1 no similarity; uncharacterized protein 691490 2895977 KLLA0_F07271g Kluyveromyces lactis uncharacterized protein XP_455410.1 690795 D 28985 CDS KLLA0_F07293g 2895978 691582..692085 F 1 NC_006042.1 similar to uniprot|P28627 Saccharomyces cerevisiae YMR150c IMP1 protease, mitochondrial; endopeptidase catalytic subunit IMP1 692085 2895978 KLLA0_F07293g Kluyveromyces lactis endopeptidase catalytic subunit IMP1 XP_455411.1 691582 D 28985 CDS KLLA0_F07315g 2895979 complement(692238..693035) F 1 NC_006042.1 similar to uniprot|Q02795 Saccharomyces cerevisiae YMR149W SWP1 oligosaccharyl transferase glycoprotein complex delta subunit; dolichyl-diphosphooligosaccharide-protein glycotransferase 693035 2895979 KLLA0_F07315g Kluyveromyces lactis dolichyl-diphosphooligosaccharide-protein glycotransferase XP_455412.1 692238 R 28985 CDS KLLA0_F07337g 2895980 complement(693418..693804) F 1 NC_006042.1 no similarity; uncharacterized protein 693804 2895980 KLLA0_F07337g Kluyveromyces lactis uncharacterized protein XP_455413.1 693418 R 28985 CDS KLLA0_F07348g 9487413 complement(694278..694541) F 1 NC_006042.1 no similarity; uncharacterized protein 694541 9487413 KLLA0_F07348g Kluyveromyces lactis uncharacterized protein XP_002999427.1 694278 R 28985 CDS KLLA0_F07359g 2895981 complement(695133..696101) F 1 NC_006042.1 some similarities with uniprot|Q03083 Saccharomyces cerevisiae YPL034W Hypothetical ORF; uncharacterized protein 696101 2895981 KLLA0_F07359g Kluyveromyces lactis uncharacterized protein XP_455414.1 695133 R 28985 CDS KLLA0_F07381g 2895931 696302..697114 F 1 NC_006042.1 similar to uniprot|Q07505 Saccharomyces cerevisiae YDL086W Hypothetical ORF; carboxymethylenebutenolidase 697114 2895931 KLLA0_F07381g Kluyveromyces lactis carboxymethylenebutenolidase XP_455415.1 696302 D 28985 CDS KLLA0_F07403g 2895932 697593..698636 F 1 NC_006042.1 similar to uniprot|P40217 Saccharomyces cerevisiae YMR146C TIF34 Subunit of the core complex of translation initiation factor 3(eIF3) which is essential for translation; translation initiation factor eIF3 subunit i 698636 2895932 KLLA0_F07403g Kluyveromyces lactis translation initiation factor eIF3 subunit i XP_455416.1 697593 D 28985 CDS KLLA0_F07425g 2895933 complement(699177..699380) F 1 NC_006042.1 similar to uniprot|Q3E7B7 Saccharomyces cerevisiae YDL085C-A; uncharacterized protein 699380 2895933 KLLA0_F07425g Kluyveromyces lactis uncharacterized protein XP_455417.1 699177 R 28985 CDS KLLA0_F07447g 2895934 700685..703612 F 1 NC_006042.1 similar to uniprot|P38995 Saccharomyces cerevisiae YDR270W CCC2 copper-transporting P-type ATPase with similarity to human Menkes and Wilsons genes; Cu(2+)-transporting ATPase; Cu(2+)-transporting P-type ATPase CCC2 703612 2895934 KLLA0_F07447g Kluyveromyces lactis Cu(2+)-transporting P-type ATPase CCC2 XP_455418.1 700685 D 28985 CDS KLLA0_F07469g 2895935 703955..706933 F 1 NC_006042.1 similar to uniprot|Q02792 Saccharomyces cerevisiae YOR048C RAT1 Nuclear 5' to 3' single-stranded RNA exonuclease involved in RNA metabolism including rRNA and snRNA processing as well as mRNA transcription termination; ssRNA exonuclease RAT1 706933 2895935 KLLA0_F07469g Kluyveromyces lactis ssRNA exonuclease RAT1 XP_455419.1 703955 D 28985 CDS KLLA0_F07513g 2895937 707516..710662 F 1 NC_006042.1 similar to uniprot|P31380 Saccharomyces cerevisiae YAL019W FUN30 Protein whose overexpression affects chromosome stability potential Cdc28p substrate homolog of Snf2p; DNA-dependent ATPase FUN30 710662 2895937 KLLA0_F07513g Kluyveromyces lactis DNA-dependent ATPase FUN30 XP_455420.1 707516 D 28985 CDS KLLA0_F07557g 2895939 complement(711607..713070) F 1 NC_006042.1 similar to uniprot|Q08220 Saccharomyces cerevisiae YOL049W GSH2 Glutathione synthetase catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine induced by oxidative stress and heat shock; glutathione synthase 713070 2895939 KLLA0_F07557g Kluyveromyces lactis glutathione synthase XP_455422.1 711607 R 28985 CDS KLLA0_F07579g 2894954 complement(713403..716507) F 1 NC_006042.1 uniprot|P32257 Kluyveromyces lactis KLLA0F07579g GAL11 Transcription regulatory protein GAL11; uncharacterized protein 716507 2894954 KLLA0_F07579g Kluyveromyces lactis uncharacterized protein XP_455423.1 713403 R 28985 CDS KLLA0_F07601g 2895940 complement(717689..718606) F 1 NC_006042.1 similar to uniprot|P31379 Saccharomyces cerevisiae YAL018C Hypothetical ORF; uncharacterized protein 718606 2895940 KLLA0_F07601g Kluyveromyces lactis uncharacterized protein XP_455424.1 717689 R 28985 CDS KLLA0_F07623g 2895941 720246..723935 F 1 NC_006042.1 similar to uniprot|P31374 Saccharomyces cerevisiae YAL017W PSK1 One of two (see also PSK2) PAS domain containing S/T protein kinases coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; uncharacterized protein 723935 2895941 KLLA0_F07623g Kluyveromyces lactis uncharacterized protein XP_455425.1 720246 D 28985 CDS KLLA0_F07645g 2895942 complement(724204..725763) F 1 NC_006042.1 similar to uniprot|P50276 Saccharomyces cerevisiae YGR055W MUP1 High affinity methionine permease; uncharacterized protein 725763 2895942 KLLA0_F07645g Kluyveromyces lactis uncharacterized protein XP_455426.1 724204 R 28985 CDS KLLA0_F07667g 2895943 726241..727314 F 1 NC_006042.1 some similarities with uniprot|Q08215 Saccharomyces cerevisiae YOL044W PEX15 Phosphorylated tail-anchored type II integral peroxisomal membrane protein; uncharacterized protein 727314 2895943 KLLA0_F07667g Kluyveromyces lactis uncharacterized protein XP_455427.1 726241 D 28985 CDS KLLA0_F07689g 2895944 727832..729664 F 1 NC_006042.1 highly similar to uniprot|P31383 Saccharomyces cerevisiae YAL016W TPD3 protein phosphatase 2A regulatory subunit A; protein phosphatase 2A structural subunit TPD3 729664 2895944 KLLA0_F07689g Kluyveromyces lactis protein phosphatase 2A structural subunit TPD3 XP_455428.1 727832 D 28985 CDS KLLA0_F07711g 2895057 complement(729829..731004) F 1 NC_006042.1 similar to uniprot|Q08214 Saccharomyces cerevisiae YOL043C NTG2 DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; uncharacterized protein 731004 2895057 KLLA0_F07711g Kluyveromyces lactis uncharacterized protein XP_455429.1 729829 R 28985 CDS KLLA0_F07733g 2895058 731317..732432 F 1 NC_006042.1 similar to uniprot|Q08213 Saccharomyces cerevisiae YOL042W; RNA exonuclease 732432 2895058 KLLA0_F07733g Kluyveromyces lactis RNA exonuclease XP_455430.1 731317 D 28985 CDS KLLA0_F07755g 2895059 732874..733497 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 733497 2895059 KLLA0_F07755g Kluyveromyces lactis uncharacterized protein XP_455431.1 732874 D 28985 CDS KLLA0_F07777g 2895060 complement(733753..734535) F 1 NC_006042.1 similar to uniprot|P31377 Saccharomyces cerevisiae YAL014C SYN8 Endosomal SNARE related to mammalian syntaxin 8; syntaxin 734535 2895060 KLLA0_F07777g Kluyveromyces lactis syntaxin XP_455432.1 733753 R 28985 CDS KLLA0_F07799g 2895061 complement(734889..736277) F 1 NC_006042.1 similar to uniprot|Q08208 Saccharomyces cerevisiae YOL041C; uncharacterized protein 736277 2895061 KLLA0_F07799g Kluyveromyces lactis uncharacterized protein XP_455433.2 734889 R 28985 CDS KLLA0_F07821g 2895062 737054..738874 F 1 NC_006042.1 similar to uniprot|Q758U6 Ashbya gossypii AEL344W and some similarities with YAL013W uniprot|P31385 Saccharomyces cerevisiae YAL013W DEP1 Transcriptional modulator involved in the regulation of structural genes involved in phospholipid biosynthesis also participates in regulation of metabolically unrelated genes as well as maintenance of mating efficiency and sporulation; Rpd3L histone deacetylase complex subunit DEP1 738874 2895062 KLLA0_F07821g Kluyveromyces lactis Rpd3L histone deacetylase complex subunit DEP1 XP_455434.1 737054 D 28985 CDS KLLA0_F07843g 2895063 complement(739661..740089) F 1 NC_006042.1 highly similar to uniprot|Q01855 Saccharomyces cerevisiae YOL040C; 40S ribosomal protein uS19 740089 2895063 KLLA0_F07843g Kluyveromyces lactis 40S ribosomal protein uS19 XP_455435.1 739661 R 28985 CDS KLLA0_F07865g 2895064 741097..741417 F 1 NC_006042.1 highly similar to uniprot|P05319 Saccharomyces cerevisiae YOL039W RPP2A Ribosomal protein P2 alpha a component of the ribosomal stalk which is involved in the interaction between translational elongation factors and the ribosome regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm; ribosomal protein P2 alpha 741417 2895064 KLLA0_F07865g Kluyveromyces lactis ribosomal protein P2 alpha XP_455436.1 741097 D 28985 CDS KLLA0_F07887g 2895065 741965..742273 F 1 NC_006042.1 no similarity; uncharacterized protein 742273 2895065 KLLA0_F07887g Kluyveromyces lactis uncharacterized protein XP_455437.1 741965 D 28985 CDS KLLA0_F07909g 2895066 742468..743643 F 1 NC_006042.1 highly similar to uniprot|P31373 Saccharomyces cerevisiae YAL012W CYS3 Cystathionine gamma-lyase catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; cystathionine gamma-lyase CYS3 743643 2895066 KLLA0_F07909g Kluyveromyces lactis cystathionine gamma-lyase CYS3 XP_455438.1 742468 D 28985 CDS KLLA0_F07931g 2895067 744157..745629 F 1 NC_006042.1 similar to uniprot|Q6B1H9 Saccharomyces cerevisiae YOL031C SIL1 ER-localized protein required for protein translocation into the ER interacts with the ATPase domain of the Kar2p chaperone suggesting some role in modulating its activity homolog of Yarrowia lipolytica SLS1 GrpE-like protein in the ER; uncharacterized protein 745629 2895067 KLLA0_F07931g Kluyveromyces lactis uncharacterized protein XP_455439.1 744157 D 28985 CDS KLLA0_F07953g 2895068 complement(745723..746451) F 1 NC_006042.1 similar to uniprot|Q08202 Saccharomyces cerevisiae YOL032W Hypothetical ORF; uncharacterized protein 746451 2895068 KLLA0_F07953g Kluyveromyces lactis uncharacterized protein XP_455440.1 745723 R 28985 CDS KLLA0_F07975g 2895069 complement(746708..748336) F 1 NC_006042.1 similar to uniprot|P48525 Saccharomyces cerevisiae YOL033W MSE1 Mitochondrial glutamyl-tRNA synthetase encoded by a nuclear gene; glutamate--tRNA ligase MSE1 748336 2895069 KLLA0_F07975g Kluyveromyces lactis glutamate--tRNA ligase MSE1 XP_455441.1 746708 R 28985 CDS KLLA0_F07997g 2895070 complement(748561..751920) F 1 NC_006042.1 similar to uniprot|Q08204 YOL034W Saccharomyces cerevisiae YOL034W SMC5 Structural maintenance of chromosomes (SMC) protein, interacts with Rhc18p and Nse1p to form a large complex; DNA repair ATPase SMC5 751920 2895070 KLLA0_F07997g Kluyveromyces lactis DNA repair ATPase SMC5 XP_455442.1 748561 R 28985 CDS KLLA0_F08019g 2894793 752184..754460 F 1 NC_006042.1 some similarities with uniprot|P31376 Saccharomyces cerevisiae YAL011W SWC3 Protein of unknown function component of the Swr1p complex that incorporates Htz1p into chromatin; uncharacterized protein 754460 2894793 KLLA0_F08019g Kluyveromyces lactis uncharacterized protein XP_455443.1 752184 D 28985 CDS KLLA0_F08041g 2894794 complement(754518..755876) F 1 NC_006042.1 similar to uniprot|P18409 Saccharomyces cerevisiae YAL010C MDM10 Subunit of the mitochondrial sorting and assembly machinery (SAM complex) has a role in assembly of the TOM complex which mediates protein import through the outer membrane required for normal mitochondrial morphology and inheritance; uncharacterized protein 755876 2894794 KLLA0_F08041g Kluyveromyces lactis uncharacterized protein XP_455444.1 754518 R 28985 CDS KLLA0_F08063g 2894795 756362..757231 F 1 NC_006042.1 similar to uniprot|P18410 Saccharomyces cerevisiae YAL009W SPO7 Integral nuclear/ER membrane protein of unknown function required for normal nuclear envelope morphology and sporulation; Nem1-Spo7 phosphatase regulatory subunit SPO7 757231 2894795 KLLA0_F08063g Kluyveromyces lactis Nem1-Spo7 phosphatase regulatory subunit SPO7 XP_455445.1 756362 D 28985 CDS KLLA0_F08085g 2894796 758631..760640 F 1 NC_006042.1 similar to uniprot|P38903 Saccharomyces cerevisiae YOR014W RTS1 B-type regulatory subunit of protein phosphatase 2A (PP2A); protein phosphatase 2A regulatory subunit RTS1 760640 2894796 KLLA0_F08085g Kluyveromyces lactis protein phosphatase 2A regulatory subunit RTS1 XP_455446.1 758631 D 28985 CDS KLLA0_F08107g 2894797 761242..761748 F 1 NC_006042.1 some similarities with uniprot|P18411 Saccharomyces cerevisiae YAL008W FUN14 Mitochondrial protein of unknown function; uncharacterized protein 761748 2894797 KLLA0_F08107g Kluyveromyces lactis uncharacterized protein XP_455447.1 761242 D 28985 CDS KLLA0_F08129g 2894798 761965..762597 F 1 NC_006042.1 highly similar to uniprot|Q06102 Saccharomyces cerevisiae YPR107C YTH1 Essential RNA-binding component of cleavage and polyadenylation factor; cleavage polyadenylation factor RNA-binding subunit YTH1 762597 2894798 KLLA0_F08129g Kluyveromyces lactis cleavage polyadenylation factor RNA-binding subunit YTH1 XP_455448.1 761965 D 28985 CDS KLLA0_F08162g 2894800 763454..764377 F 1 NC_006042.1 highly similar to uniprot|P53252 Saccharomyces cerevisiae YGR086C PIL1 Long chain base-responsive inhibitor of protein kinases Phk1p and Phk2p acts along with Lsp1p to down-regulate heat stress resistance via regulation of the Pkc1p and Ypk1p pathways phosphorylated by Phk1p and Phk2p; lipid-binding protein PIL1 764377 2894800 KLLA0_F08162g Kluyveromyces lactis lipid-binding protein PIL1 XP_455450.1 763454 D 28985 CDS KLLA0_F08184g 2894801 765209..767512 F 1 NC_006042.1 similar to uniprot|Q06096 Saccharomyces cerevisiae YPR105C COG4 component of oligomeric Golgi complex; Golgi transport complex subunit COG4 767512 2894801 KLLA0_F08184g Kluyveromyces lactis Golgi transport complex subunit COG4 XP_455451.1 765209 D 28985 CDS KLLA0_F08206g 2895785 767745..770261 F 1 NC_006042.1 similar to uniprot|P39521 Saccharomyces cerevisiae YPR104C; uncharacterized protein 770261 2895785 KLLA0_F08206g Kluyveromyces lactis uncharacterized protein XP_455452.1 767745 D 28985 CDS KLLA0_F08228g 2895786 complement(770578..771435) F 1 NC_006042.1 highly similar to uniprot|P30656 Saccharomyces cerevisiae YPR103W PRE2 20S proteasome beta-type subunit; proteasome core particle subunit beta 5 771435 2895786 KLLA0_F08228g Kluyveromyces lactis proteasome core particle subunit beta 5 XP_455453.1 770578 R 28985 CDS KLLA0_F08261g 2895788 772179..772703 F 1 NC_006042.1 highly similar to uniprot|P06380 Saccharomyces cerevisiae RPL11A and to uniprot|P06380 Saccharomyces cerevisiae YGR085C RPL11B component of the large (60S) ribosomal subunit; 60S ribosomal protein uL5 772703 2895788 KLLA0_F08261g Kluyveromyces lactis 60S ribosomal protein uL5 XP_455455.1 772179 D 28985 CDS KLLA0_F08283g 2895789 complement(772816..773331) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 773331 2895789 KLLA0_F08283g Kluyveromyces lactis uncharacterized protein XP_455456.1 772816 R 28985 CDS KLLA0_F08305g 2895790 773720..774685 F 1 NC_006042.1 similar to uniprot|P12686 Saccharomyces cerevisiae YGR084C MRP13 Mitochondrial ribosomal protein of the small subunit; uncharacterized protein 774685 2895790 KLLA0_F08305g Kluyveromyces lactis uncharacterized protein XP_455457.1 773720 D 28985 CDS KLLA0_F08327g 2895791 775125..776933 F 1 NC_006042.1 similar to uniprot|P12754 Saccharomyces cerevisiae YGR083C GCD2 Delta subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression; translation initiation factor eIF2B subunit delta 776933 2895791 KLLA0_F08327g Kluyveromyces lactis translation initiation factor eIF2B subunit delta XP_455458.1 775125 D 28985 CDS KLLA0_F08349g 2895792 complement(777144..777572) F 1 NC_006042.1 highly similar to uniprot|Q06090 Saccharomyces cerevisiae YPR100W MRPL51 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein mL43 777572 2895792 KLLA0_F08349g Kluyveromyces lactis mitochondrial 54S ribosomal protein mL43 XP_455459.1 777144 R 28985 CDS KLLA0_F08371g 2895793 779264..781009 F 1 NC_006042.1 no similarity; uncharacterized protein 781009 2895793 KLLA0_F08371g Kluyveromyces lactis uncharacterized protein XP_455460.1 779264 D 28985 CDS KLLA0_F08393g 2894951 complement(781508..783019) F 1 NC_006042.1 uniprot|P09608 Kluyveromyces lactis KLLA0F08393g GAL1 Galactokinase; galactokinase 783019 2894951 KLLA0_F08393g Kluyveromyces lactis galactokinase XP_455461.1 781508 R 28985 CDS KLLA0_F08415g 2894953 783785..785851 F 1 NC_006042.1 uniprot|P09609 Kluyveromyces lactis KLLA0F08415g GAL10 GAL10 bifunctional protein; bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase 785851 2894953 KLLA0_F08415g Kluyveromyces lactis bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase XP_455462.1 783785 D 28985 CDS KLLA0_F08437g 2894952 786742..787854 F 1 NC_006042.1 uniprot|P09580 Kluyveromyces lactis KLLA0F08437g GAL7 Galactose-1-phosphate uridylyltransferase; UDP-glucose:hexose-1-phosphate uridylyltransferase 787854 2894952 KLLA0_F08437g Kluyveromyces lactis UDP-glucose:hexose-1-phosphate uridylyltransferase XP_455463.1 786742 D 28985 CDS KLLA0_F08459g 2895794 complement(787966..790479) F 1 NC_006042.1 similar to uniprot|P12945 Saccharomyces cerevisiae YDL040C NAT1 Subunit of the N-terminal acetyltransferase NatA (Nat1p Ard1p Nat5p) N-terminally acetylates many proteins which influences multiple processes such as the cell cycle heat-shock resistance mating sporulation and telomeric silencing; peptide alpha-N-acetyltransferase complex A subunit NAT1 790479 2895794 KLLA0_F08459g Kluyveromyces lactis peptide alpha-N-acetyltransferase complex A subunit NAT1 XP_455464.1 787966 R 28985 CDS KLLA0_F08481g 2895795 complement(790859..792310) F 1 NC_006042.1 similar to uniprot|Q02554 Saccharomyces cerevisiae YMR240C CUS1 Protein required for assembly of U2 snRNP into the spliceosome forms a complex with Hsh49p and Hsh155p; U2 snRNP complex subunit CUS1 792310 2895795 KLLA0_F08481g Kluyveromyces lactis U2 snRNP complex subunit CUS1 XP_455465.1 790859 R 28985 CDS KLLA0_F08492g 9487351 complement(792545..792775) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 792775 9487351 KLLA0_F08492g Kluyveromyces lactis uncharacterized protein XP_002999428.1 792545 R 28985 CDS KLLA0_F08503g 2895796 792967..793668 F 1 NC_006042.1 similar to uniprot|Q08774 Saccharomyces cerevisiae YOR305W Hypothetical ORF; uncharacterized protein 793668 2895796 KLLA0_F08503g Kluyveromyces lactis uncharacterized protein XP_455466.1 792967 D 28985 CDS KLLA0_F08525g 2895797 complement(793929..795410) F 1 NC_006042.1 similar to uniprot|Q08777 Saccharomyces cerevisiae YOR306C MCH5 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport; riboflavin transporter 795410 2895797 KLLA0_F08525g Kluyveromyces lactis riboflavin transporter XP_455467.1 793929 R 28985 CDS KLLA0_F08547g 2895761 796328..797254 F 1 NC_006042.1 highly similar to uniprot|Q04013 Saccharomyces cerevisiae YMR241W YHM2 Yeast suppressor gene of HM mutant (abf2) DNA-binding protein mtDNA stabilizing protein mitochondrial inner membrane protein with low homology to RIM2; uncharacterized protein 797254 2895761 KLLA0_F08547g Kluyveromyces lactis uncharacterized protein XP_455468.1 796328 D 28985 CDS KLLA0_F08569g 2895762 complement(797808..799151) F 1 NC_006042.1 similar to uniprot|P22215 Saccharomyces cerevisiae YOR307C SLY41 multicopy suppressor of ypt1 deletion homolog of chloroplast phosphate transporter; uncharacterized protein 799151 2895762 KLLA0_F08569g Kluyveromyces lactis uncharacterized protein XP_455469.1 797808 R 28985 CDS KLLA0_F08591g 2895763 complement(799590..801263) F 1 NC_006042.1 weakly similar to uniprot|Q12420 Saccharomyces cerevisiae YOR308C SNU66 66kD U4/U6.U5 snRNP associated protein; U4/U6-U5 snRNP complex subunit SNU66 801263 2895763 KLLA0_F08591g Kluyveromyces lactis U4/U6-U5 snRNP complex subunit SNU66 XP_455470.1 799590 R 28985 CDS KLLA0_F08613g 2895764 complement(801623..803158) F 1 NC_006042.1 similar to uniprot|Q12499 Saccharomyces cerevisiae YOR310C NOP58 Protein involved in pre-rRNA processing 18S rRNA synthesis and snoRNA synthesis component of the small subunit processome complex which is required for processing of pre-18S rRNA; RNA-processing protein NOP58 803158 2895764 KLLA0_F08613g Kluyveromyces lactis RNA-processing protein NOP58 XP_455471.1 801623 R 28985 CDS KLLA0_F08635g 2895765 complement(803832..804683) F 1 NC_006042.1 similar to uniprot|Q12382 Saccharomyces cerevisiae YOR311C HSD1 Endoplasmic reticulum (ER)-resident membrane protein overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; diacylglycerol kinase 804683 2895765 KLLA0_F08635g Kluyveromyces lactis diacylglycerol kinase XP_455472.1 803832 R 28985 CDS KLLA0_F08657g 2895766 complement(805298..805738) F 1 NC_006042.1 highly similar to uniprot|P47913 Saccharomyces cerevisiae YOR312C RPL20B and highly similar to uniprot|P47913 Saccharomyces cerevisiae YMR242C RPL20A Protein component of the large (60S) ribosomal subunit; 60S ribosomal protein eL20 805738 2895766 KLLA0_F08657g Kluyveromyces lactis 60S ribosomal protein eL20 XP_455473.2 805298 R 28985 CDS KLLA0_F08679g 2895767 complement(807369..808451) F 1 NC_006042.1 weakly similar to uniprot|P09937 Saccharomyces cerevisiae YOR313C SPS4 Protein whose expression is induced during sporulation not required for sporulation heterologous expression in E. coli induces the SOS response that senses DNA damage; uncharacterized protein 808451 2895767 KLLA0_F08679g Kluyveromyces lactis uncharacterized protein XP_455474.1 807369 R 28985 CDS KLLA0_F08701g 2895768 811112..812152 F 1 NC_006042.1 weakly similar to uniprot|Q12507 Saccharomyces cerevisiae YOR315W Protein of unknown function found in the cytoplasm and the nucleus potential Cdc28p substrate; uncharacterized protein 812152 2895768 KLLA0_F08701g Kluyveromyces lactis uncharacterized protein XP_455475.1 811112 D 28985 CDS KLLA0_F08723g 2895769 complement(813012..814322) F 1 NC_006042.1 similar to uniprot|P20107 Saccharomyces cerevisiae YMR243C ZRC1 and to uniprot|P32798 Saccharomyces cerevisiae YOR316C COT1; uncharacterized protein 814322 2895769 KLLA0_F08723g Kluyveromyces lactis uncharacterized protein XP_455476.1 813012 R 28985 CDS KLLA0_F08745g 2895770 815922..816983 F 1 NC_006042.1 similar to uniprot|Q04018 Saccharomyces cerevisiae YMR244W Hypothetical ORF; uncharacterized protein 816983 2895770 KLLA0_F08745g Kluyveromyces lactis uncharacterized protein XP_455477.1 815922 D 28985 CDS KLLA0_F08767g 2895771 complement(817541..817837) F 1 NC_006042.1 similar to uniprot|Q3E846 Saccharomyces cerevisiae YMR244C-A Hypothetical ORF; uncharacterized protein 817837 2895771 KLLA0_F08767g Kluyveromyces lactis uncharacterized protein XP_455478.1 817541 R 28985 CDS KLLA0_F08789g 2895772 818541..819731 F 1 NC_006042.1 some similarities with uniprot|P43570 Saccharomyces cerevisiae YFL027C GYP8 GTPase-activating protein for yeast Rab family members Ypt1p is the preferred in vitro substrate but also acts on Sec4p Ypt31p and Ypt32p involved in the regulation of ER to Golgi vesicle transport; GTPase-activating protein GYP8 819731 2895772 KLLA0_F08789g Kluyveromyces lactis GTPase-activating protein GYP8 XP_455479.1 818541 D 28985 CDS KLLA0_F08811g 2895773 complement(819834..821744) F 1 NC_006042.1 similar to uniprot|P38915 Saccharomyces cerevisiae YLR055C SPT8 Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA required for SAGA-mediated inhibition at some promoters; SAGA complex subunit SPT8 821744 2895773 KLLA0_F08811g Kluyveromyces lactis SAGA complex subunit SPT8 XP_455480.1 819834 R 28985 CDS KLLA0_F08833g 2895774 822039..822860 F 1 NC_006042.1 similar to uniprot|P43569 Saccharomyces cerevisiae YFL028C CAF16 Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation elongation and degradation putative ABC ATPase interacts with Ssn2p Ssn3p and Ssn8p; uncharacterized protein 822860 2895774 KLLA0_F08833g Kluyveromyces lactis uncharacterized protein XP_455481.1 822039 D 28985 CDS KLLA0_F08855g 2895982 823595..824656 F 1 NC_006042.1 similar to uniprot|P32353 Saccharomyces cerevisiae YLR056W ERG3 C-5 sterol desaturase catalyzes the introduction of a C-5(6) double bond into episterol a precursor in ergosterol biosynthesis mutants are viable but cannot grow on non-fermentable carbon sources; C-5 sterol desaturase 824656 2895982 KLLA0_F08855g Kluyveromyces lactis C-5 sterol desaturase XP_455482.1 823595 D 28985 CDS KLLA0_F08877g 2895983 825217..826182 F 1 NC_006042.1 uniprot|Q8J0L1 Kluyveromyces lactis cak1 Cyclin-dependent kinase activating kinase 1; cyclin-dependent protein kinase-activating kinase CAK1 826182 2895983 KLLA0_F08877g Kluyveromyces lactis cyclin-dependent protein kinase-activating kinase CAK1 XP_455483.1 825217 D 28985 CDS KLLA0_F08899g 2895984 826574..828685 F 1 NC_006042.1 weakly similar to uniprot|Q7LGY1 Saccharomyces cerevisiae YLR057W Hypothetical ORF; uncharacterized protein 828685 2895984 KLLA0_F08899g Kluyveromyces lactis uncharacterized protein XP_455484.1 826574 D 28985 CDS KLLA0_F08921g 2895985 complement(829001..830410) F 1 NC_006042.1 highly similar to uniprot|P37291 Saccharomyces cerevisiae YLR058C SHM2 serine hydroxymethyltransferase; glycine hydroxymethyltransferase SHM2 830410 2895985 KLLA0_F08921g Kluyveromyces lactis glycine hydroxymethyltransferase SHM2 XP_455485.1 829001 R 28985 CDS KLLA0_F08954g 2895987 complement(831232..832335) F 1 NC_006042.1 similar to uniprot|P43567 Saccharomyces cerevisiae YFL030W; alanine--glyoxylate transaminase 832335 2895987 KLLA0_F08954g Kluyveromyces lactis alanine--glyoxylate transaminase XP_455487.1 831232 R 28985 CDS KLLA0_F08976g 2895988 complement(833390..834211) F 1 NC_006042.1 some similarities with uniprot|P41546 Saccharomyces cerevisiae YFL031W HAC1 bZIP transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response; transcription factor HAC1 834211 2895988 KLLA0_F08976g Kluyveromyces lactis transcription factor HAC1 XP_455488.1 833390 R 28985 CDS KLLA0_F08998g 2895989 complement(834717..835637) F 1 NC_006042.1 similar to uniprot|P54964 Saccharomyces cerevisiae YLR059C REX2 RNA exonuclease required for U4 snRNA maturation functions redundantly with Rnh70p in 5.8S rRNA maturation and with Rnh70p and Rex3p in processing of U5 snRNA and RNase P RNA member of RNase D family of exonucleases; uncharacterized protein 835637 2895989 KLLA0_F08998g Kluyveromyces lactis uncharacterized protein XP_455489.1 834717 R 28985 CDS KLLA0_F09053g 2895992 842591..843949 F 1 NC_006042.1 similar to uniprot|Q00362 Saccharomyces cerevisiae YGL190C CDC55 Non-essential regulatory subunit B of protein phosphatase 2A has multiple roles in mitosis and protein biosynthesis found in the nucleus of most cells but also at the bud neck (large-budded cells) and at the bud tip (small-budded cells); protein phosphatase 2A regulatory subunit CDC55 843949 2895992 KLLA0_F09053g Kluyveromyces lactis protein phosphatase 2A regulatory subunit CDC55 XP_455492.1 842591 D 28985 CDS KLLA0_F09075g 2895993 complement(844701..845084) F 1 NC_006042.1 highly similar to uniprot|P32799 Saccharomyces cerevisiae YGL191W COX13 Subunit VIa of cytochrome c oxidase which is the terminal member of the mitochondrial inner membrane electron transport chain not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; cytochrome c oxidase subunit VIa 845084 2895993 KLLA0_F09075g Kluyveromyces lactis cytochrome c oxidase subunit VIa XP_455493.1 844701 R 28985 CDS KLLA0_F09097g 2896028 complement(846171..847745) F 1 NC_006042.1 similar to uniprot|P41833 Saccharomyces cerevisiae YGL192W IME4 Probable mRNA N6-adenosine methyltransferase that is required for IME1 transcript accumulation and for sporulation expression is induced in starved MATa/MAT alpha diploid cells; mRNA (N6-adenosine)-methyltransferase 847745 2896028 KLLA0_F09097g Kluyveromyces lactis mRNA (N6-adenosine)-methyltransferase XP_455494.1 846171 R 28985 CDS KLLA0_F09119g 2896029 848467..849825 F 1 NC_006042.1 highly similar to uniprot|P53096 Saccharomyces cerevisiae YGL194C HOS2 Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails subunit of the Set3 complex a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; histone deacetylase HOS2 849825 2896029 KLLA0_F09119g Kluyveromyces lactis histone deacetylase HOS2 XP_455495.1 848467 D 28985 CDS KLLA0_F09141g 2896030 complement(850288..851358) F 1 NC_006042.1 uniprot|Q8J0C9 Kluyveromyces lactis KLLA0F09141g gdp1 NADP glyceraldehyde 3-phosphate dehydrogenase; uncharacterized protein 851358 2896030 KLLA0_F09141g Kluyveromyces lactis uncharacterized protein XP_455496.1 850288 R 28985 CDS KLLA0_F09163g 2896031 complement(852529..853803) F 1 NC_006042.1 similar to uniprot|P53100 Saccharomyces cerevisiae YGL185C Putative hydroxyacid dehydrogenase; uncharacterized protein 853803 2896031 KLLA0_F09163g Kluyveromyces lactis uncharacterized protein XP_455497.1 852529 R 28985 CDS KLLA0_F09185g 2896032 854314..855651 F 1 NC_006042.1 highly similar to uniprot|P39958 Saccharomyces cerevisiae YER136W GDI1 GDP dissociation inhibitor regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins; uncharacterized protein 855651 2896032 KLLA0_F09185g Kluyveromyces lactis uncharacterized protein XP_455498.1 854314 D 28985 CDS KLLA0_F09207g 2896033 856056..856343 F 1 NC_006042.1 highly similar to uniprot|P38203 Saccharomyces cerevisiae YBL026W LSM2 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay; Sm-like protein LSM2 856343 2896033 KLLA0_F09207g Kluyveromyces lactis Sm-like protein LSM2 XP_455499.1 856056 D 28985 CDS KLLA0_F09229g 2896034 complement(856467..856856) F 1 NC_006042.1 similar to uniprot|P40083 Saccharomyces cerevisiae YER137C Hypothetical ORF; uncharacterized protein 856856 2896034 KLLA0_F09229g Kluyveromyces lactis uncharacterized protein XP_455500.1 856467 R 28985 CDS KLLA0_F09251g 2896035 complement(857154..857921) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 857921 2896035 KLLA0_F09251g Kluyveromyces lactis uncharacterized protein XP_455501.1 857154 R 28985 CDS KLLA0_F09273g 2896036 858627..859655 F 1 NC_006042.1 highly similar to uniprot|P05373 Saccharomyces cerevisiae YGL040C HEM2 Delta-aminolevulinate dehydratase a homo-octameric enzyme catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen the second step in the heme biosynthetic pathway localizes to both the cytoplasm and nucleus; porphobilinogen synthase HEM2 859655 2896036 KLLA0_F09273g Kluyveromyces lactis porphobilinogen synthase HEM2 XP_455502.1 858627 D 28985 CDS KLLA0_F09295g 2895240 complement(860011..860676) F 1 NC_006042.1 similar to uniprot|Q04272 Saccharomyces cerevisiae YMR077C VPS20 vaculolar protein sorting (putative); ESCRT-III subunit protein VPS20 860676 2895240 KLLA0_F09295g Kluyveromyces lactis ESCRT-III subunit protein VPS20 XP_455503.1 860011 R 28985 CDS KLLA0_F09317g 2895241 861757..863238 F 1 NC_006042.1 similar to uniprot|P32582 Saccharomyces cerevisiae YGR155W CYS4 Cystathionine beta-synthase catalyzes the synthesis of cystathionine from serine and homocysteine the first committed step in cysteine biosynthesis; cystathionine beta-synthase CYS4 863238 2895241 KLLA0_F09317g Kluyveromyces lactis cystathionine beta-synthase CYS4 XP_455504.1 861757 D 28985 CDS KLLA0_F09339g 2895242 complement(863495..863920) F 1 NC_006042.1 similar to uniprot|P0C5N3 Saccharomyces cerevisiae YGL041W-A Identified by expression profiling and mass spectrometry; uncharacterized protein 863920 2895242 KLLA0_F09339g Kluyveromyces lactis uncharacterized protein XP_455505.1 863495 R 28985 CDS KLLA0_F09361g 2895243 complement(864425..865303) F 1 NC_006042.1 similar to uniprot|P07273 YGL043W Saccharomyces cerevisiae DST1 General transcription elongation factor TFIIS; transcription elongation factor DST1 865303 2895243 KLLA0_F09361g Kluyveromyces lactis transcription elongation factor DST1 XP_455506.1 864425 R 28985 CDS KLLA0_F09383g 2895244 865710..866486 F 1 NC_006042.1 similar to uniprot|P25299 Saccharomyces cerevisiae YGL044C RNA15 Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; uncharacterized protein 866486 2895244 KLLA0_F09383g Kluyveromyces lactis uncharacterized protein XP_455507.1 865710 D 28985 CDS KLLA0_F09405g 2895245 867882..869513 F 1 NC_006042.1 similar to uniprot|P40445 Saccharomyces cerevisiae YIL166C Hypothetical ORF, member of the Dal5p subfamily of the major facilitator family; uncharacterized protein 869513 2895245 KLLA0_F09405g Kluyveromyces lactis uncharacterized protein XP_455508.1 867882 D 28985 CDS KLLA0_F09427g 2895246 complement(869664..871307) F 1 NC_006042.1 weakly similar to uniprot|P25568 Saccharomyces cerevisiae YCL038C; uncharacterized protein 871307 2895246 KLLA0_F09427g Kluyveromyces lactis uncharacterized protein XP_455509.1 869664 R 28985 CDS KLLA0_F09449g 2895247 872881..874605 F 1 NC_006042.1 highly similar to uniprot|P19882 Saccharomyces cerevisiae YLR259C HSP60 Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; similarity to groEL; chaperone ATPase HSP60 874605 2895247 KLLA0_F09449g Kluyveromyces lactis chaperone ATPase HSP60 XP_455510.1 872881 D 28985 CDS KLLA0_F09526g 2895250 875250..876263 F 1 NC_006042.1 similar to uniprot|Q75EB2 Ashbya gossypii AAR165W AAR165Wp and weakly similar to YGL126W uniprot|P53012 Saccharomyces cerevisiae SCS3 Protein required for inositol prototrophy; uncharacterized protein 876263 2895250 KLLA0_F09526g Kluyveromyces lactis uncharacterized protein XP_455512.1 875250 D 28985 CDS KLLA0_F09559g 2895252 complement(876719..878695) F 1 NC_006042.1 some similarities with uniprot|P35995 Saccharomyces cerevisiae YKL222c; uncharacterized protein 878695 2895252 KLLA0_F09559g Kluyveromyces lactis uncharacterized protein XP_455514.1 876719 R 28985 CDS KLLA0_F09581g 2895253 complement(879983..881536) F 1 NC_006042.1 similar to uniprot|P38318 Saccharomyces cerevisiae YBR220C Hypothetical ORF; uncharacterized protein 881536 2895253 KLLA0_F09581g Kluyveromyces lactis uncharacterized protein XP_455515.1 879983 R 28985 CDS KLLA0_F09603g 2895254 complement(882778..883842) F 1 NC_006042.1 highly similar to uniprot|P32473 Saccharomyces cerevisiae YBR221C PDB1 E1 beta subunit of the pyruvate dehydrogenase (PDH) complex which is an evolutionarily-conserved multi-protein complex found in mitochondria; pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta 883842 2895254 KLLA0_F09603g Kluyveromyces lactis pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta XP_455516.1 882778 R 28985 CDS KLLA0_F09625g 2894955 complement(884902..886395) F 1 NC_006042.1 weakly similar to uniprot|P38319 Saccharomyces cerevisiae YBR223C TDP1 Tyrosine-DNA Phosphodiesterase; tyrosyl-DNA phosphodiesterase 1 886395 2894955 KLLA0_F09625g Kluyveromyces lactis tyrosyl-DNA phosphodiesterase 1 XP_455517.1 884902 R 28985 CDS KLLA0_F09647g 2894956 887288..889102 F 1 NC_006042.1 similar to uniprot|P53128 Saccharomyces cerevisiae YGL125W MET13 Isozyme of methylenetetrahydrofolate reductase catalyzes the reduction of 5 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway; methylenetetrahydrofolate reductase (NAD(P)H) MET13 889102 2894956 KLLA0_F09647g Kluyveromyces lactis methylenetetrahydrofolate reductase (NAD(P)H) MET13 XP_455518.1 887288 D 28985 CDS KLLA0_F09669g 2894957 890193..892073 F 1 NC_006042.1 similar to uniprot|P38321 Saccharomyces cerevisiae YBR225W Hypothetical ORF; uncharacterized protein 892073 2894957 KLLA0_F09669g Kluyveromyces lactis uncharacterized protein XP_455519.1 890193 D 28985 CDS KLLA0_F09691g 2894958 complement(892208..893725) F 1 NC_006042.1 similar to uniprot|P38323 Saccharomyces cerevisiae YBR227C MCX1; uncharacterized protein 893725 2894958 KLLA0_F09691g Kluyveromyces lactis uncharacterized protein XP_455520.1 892208 R 28985 CDS KLLA0_F09713g 2894959 894192..895058 F 1 NC_006042.1 similar to uniprot|P38324 Saccharomyces cerevisiae YBR228W SLX1 Subunit of a complex with Slx4p that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks function overlaps with that of Sgs1p-Top3p; endonuclease 895058 2894959 KLLA0_F09713g Kluyveromyces lactis endonuclease XP_455521.1 894192 D 28985 CDS KLLA0_F09735g 2894960 complement(895086..897818) F 1 NC_006042.1 similar to uniprot|P38138 Saccharomyces cerevisiae YBR229C ROT2 Glucosidase II catalytic subunit required for normal cell wall synthesis mutations in rot2 suppress tor2 mutations and are synthetically lethal with rot1 mutations; glucan 1,3-alpha-glucosidase ROT2 897818 2894960 KLLA0_F09735g Kluyveromyces lactis glucan 1,3-alpha-glucosidase ROT2 XP_455522.1 895086 R 28985 CDS KLLA0_F09757g 2894961 898398..899156 F 1 NC_006042.1 some similarities with uniprot|P40209 Saccharomyces cerevisiae YMR136W GAT2 Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; uncharacterized protein 899156 2894961 KLLA0_F09757g Kluyveromyces lactis uncharacterized protein XP_455523.1 898398 D 28985 CDS KLLA0_F09768g 2894962 complement(899099..900685) F 1 NC_006042.1 weakly similar to uniprot|P53129 Saccharomyces cerevisiae YGL124C MON1 Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole associates as a complex with Ccz1p with a perivacuolar compartment potential Cdc28p substrate; uncharacterized protein 900685 2894962 KLLA0_F09768g Kluyveromyces lactis uncharacterized protein XP_455524.1 899099 R 28985 CDS KLLA0_F09790g 2894963 complement(901211..901738) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 901738 2894963 KLLA0_F09790g Kluyveromyces lactis uncharacterized protein XP_455525.1 901211 R 28985 CDS KLLA0_F09812g 2894964 903154..903933 F 1 NC_006042.1 similar to uniprot|P25443 Saccharomyces cerevisiae YGL123W RPS2; 40S ribosomal protein uS5 903933 2894964 KLLA0_F09812g Kluyveromyces lactis 40S ribosomal protein uS5 XP_455527.1 903154 D 28985 CDS KLLA0_F09845g 2894966 complement(904512..906080) F 1 NC_006042.1 similar to uniprot|Q75E99 Ashbya gossypii AAR178C AAR178Cp and some similarites with YGL122C uniprot|P32505 Saccharomyces cerevisiae YGL122C NAB2 Nuclear polyadenylated RNA-binding protein related to human hnRNPs has a nuclear localization signal sequence that binds to Kap104p required for both poly(A) tail length control and nuclear export of mRNA; mRNA-binding protein NAB2 906080 2894966 KLLA0_F09845g Kluyveromyces lactis mRNA-binding protein NAB2 XP_455528.1 904512 R 28985 CDS KLLA0_F09867g 2894967 complement(906641..907750) F 1 NC_006042.1 no similarity; uncharacterized protein 907750 2894967 KLLA0_F09867g Kluyveromyces lactis uncharacterized protein XP_455529.1 906641 R 28985 CDS KLLA0_F09889g 2894946 907978..911079 F 1 NC_006042.1 uniprot|Q00976 Kluyveromyces lactis KLLA0F09889g SPT16 FACT complex subunit SPT16; chromatin-remodeling protein SPT16 911079 2894946 KLLA0_F09889g Kluyveromyces lactis chromatin-remodeling protein SPT16 XP_455530.1 907978 D 28985 CDS KLLA0_F09911g 2895010 complement(911305..916269) F 1 NC_006042.1 highly similar to uniprot|P22137 Saccharomyces cerevisiae YGL206C CHC1 vesicle coat protein presumed vesicle coat protein; clathrin heavy chain 916269 2895010 KLLA0_F09911g Kluyveromyces lactis clathrin heavy chain XP_455531.1 911305 R 28985 CDS KLLA0_F09933g 2895011 918014..920224 F 1 NC_006042.1 similar to uniprot|P13711 Saccharomyces cerevisiae YGL205W POX1 Fatty-acyl coenzyme A oxidase involved in the fatty acid beta-oxidation pathway localized to the peroxisomal matrix; acyl-CoA oxidase 920224 2895011 KLLA0_F09933g Kluyveromyces lactis acyl-CoA oxidase XP_455532.1 918014 D 28985 CDS KLLA0_F09955g 2895012 920896..921720 F 1 NC_006042.1 similar to uniprot|P08456 Saccharomyces cerevisiae YER026C CHO1 phosphatidylserine synthase; CDP-diacylglycerol-serine O-phosphatidyltransferase 921720 2895012 KLLA0_F09955g Kluyveromyces lactis CDP-diacylglycerol-serine O-phosphatidyltransferase XP_455533.1 920896 D 28985 CDS KLLA0_F09977g 2895013 922726..923340 F 1 NC_006042.1 no similarity; uncharacterized protein 923340 2895013 KLLA0_F09977g Kluyveromyces lactis uncharacterized protein XP_455534.1 922726 D 28985 CDS KLLA0_F09999g 2895014 complement(923413..925341) F 1 NC_006042.1 similar to uniprot|P09620 Saccharomyces cerevisiae YGL203C KEX1 Protease involved in the processing of killer toxin and alpha factor precursor cleaves Lys and Arg residues from the C-terminus of peptides and proteins; serine-type carboxypeptidase 925341 2895014 KLLA0_F09999g Kluyveromyces lactis serine-type carboxypeptidase XP_455535.1 923413 R 28985 CDS KLLA0_F10021g 2895015 926569..928062 F 1 NC_006042.1 similar to uniprot|P53090 Saccharomyces cerevisiae YGL202W ARO8 Aromatic aminotransferase expression is regulated by general control of amino acid biosynthesis; bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase 928062 2895015 KLLA0_F10021g Kluyveromyces lactis bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase XP_455536.1 926569 D 28985 CDS KLLA0_F10043g 2895016 complement(928691..930277) F 1 NC_006042.1 uniprot|Q701Q9 Kluyveromyces lactis KLLA0F10043g jen2 Carboxylic acid permease; uncharacterized protein 930277 2895016 KLLA0_F10043g Kluyveromyces lactis uncharacterized protein XP_455537.1 928691 R 28985 CDS KLLA0_F10065g 2895017 complement(931989..934694) F 1 NC_006042.1 highly similar to uniprot|P06738 Saccharomyces cerevisiae YPR160W GPH1 Non-essential glycogen phosphorylase required for the mobilization of glycogen activity is regulated by cyclic AMP-mediated phosphorylation expression is regulated by stress-response elements and by the HOG MAP kinase pathway; glycogen phosphorylase 934694 2895017 KLLA0_F10065g Kluyveromyces lactis glycogen phosphorylase XP_455538.1 931989 R 28985 CDS KLLA0_F10087g 2895018 complement(935618..938629) F 1 NC_006042.1 similar to uniprot|P53091 Saccharomyces cerevisiae YGL201C MCM6 Protein involved in DNA replication component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; MCM DNA helicase complex subunit MCM6 938629 2895018 KLLA0_F10087g Kluyveromyces lactis MCM DNA helicase complex subunit MCM6 XP_455539.1 935618 R 28985 CDS KLLA0_F10109g 2895880 complement(939195..941066) F 1 NC_006042.1 weakly similar to uniprot|Q00947 Saccharomyces cerevisiae YDR463W STP1 Transcription factor activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids activates transcription of amino acid permease genes and may have a role in tRNA processing; uncharacterized protein 941066 2895880 KLLA0_F10109g Kluyveromyces lactis uncharacterized protein XP_455540.1 939195 R 28985 CDS KLLA0_F10131g 2895881 complement(942082..943392) F 1 NC_006042.1 similar to uniprot|Q03697 Saccharomyces cerevisiae YML038C YMD8; uncharacterized protein 943392 2895881 KLLA0_F10131g Kluyveromyces lactis uncharacterized protein XP_455541.1 942082 R 28985 CDS KLLA0_F10153g 2895882 943788..944348 F 1 NC_006042.1 similar to uniprot|P25654 Saccharomyces cerevisiae YCR090C Hypothetical ORF; uncharacterized protein 944348 2895882 KLLA0_F10153g Kluyveromyces lactis uncharacterized protein XP_455542.1 943788 D 28985 CDS KLLA0_F10175g 2895883 complement(944501..946231) F 1 NC_006042.1 similar to uniprot|P15891 Saccharomyces cerevisiae YCR088W ABP1 Actin-binding protein of the cortical actin cytoskeleton important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; uncharacterized protein 946231 2895883 KLLA0_F10175g Kluyveromyces lactis uncharacterized protein XP_455543.1 944501 R 28985 CDS KLLA0_F10198g 9487425 946952..947194 F 1 NC_006042.1 no similarity; uncharacterized protein 947194 9487425 KLLA0_F10198g Kluyveromyces lactis uncharacterized protein XP_002999429.1 946952 D 28985 CDS KLLA0_F10219g 2895885 948000..948467 F 1 NC_006042.1 similar to uniprot|P37263 Saccharomyces cerevisiae YCR087C-A Hypothetical ORF; uncharacterized protein 948467 2895885 KLLA0_F10219g Kluyveromyces lactis uncharacterized protein XP_455545.1 948000 D 28985 CDS KLLA0_F10241g 2895886 complement(948591..949121) F 1 NC_006042.1 similar to uniprot|P25651 Saccharomyces cerevisiae YCR086W CSM1 Protein that forms a complex with Lrs4p located in the nucleolus Lrs4p-Csm1p heterodimer binds to Mam1p at kinetochores during meiosis I to mediate accurate chromosome segregation may be involved in premeiotic DNA replication; uncharacterized protein 949121 2895886 KLLA0_F10241g Kluyveromyces lactis uncharacterized protein XP_455546.1 948591 R 28985 CDS KLLA0_F10263g 2895005 949926..951974 F 1 NC_006042.1 uniprot|P56094 Kluyveromyces lactis KLLA0F10263g TUP1 Transcriptional repressor TUP1; chromatin-silencing transcriptional regulator TUP1 951974 2895005 KLLA0_F10263g Kluyveromyces lactis chromatin-silencing transcriptional regulator TUP1 XP_455547.1 949926 D 28985 CDS KLLA0_F10285g 2895887 complement(952632..953825) F 1 NC_006042.1 similar to uniprot|P32377 Saccharomyces cerevisiae YNR043W MVD1 Mevalonate pyrophosphate decarboxylase essential enzyme involved in the biosynthesis of isoprenoids and sterols including ergosterol acts as a homodimer; diphosphomevalonate decarboxylase MVD1 953825 2895887 KLLA0_F10285g Kluyveromyces lactis diphosphomevalonate decarboxylase MVD1 XP_455548.1 952632 R 28985 CDS KLLA0_F10307g 2895888 954558..955673 F 1 NC_006042.1 similar to uniprot|P32378 Saccharomyces cerevisiae YNR041C COQ2 Para hydroxybenzoate: polyprenyl transferase catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis; 4-hydroxybenzoate octaprenyltransferase 955673 2895888 KLLA0_F10307g Kluyveromyces lactis 4-hydroxybenzoate octaprenyltransferase XP_455549.1 954558 D 28985 CDS KLLA0_F10329g 2895889 complement(955834..956634) F 1 NC_006042.1 similar to uniprot|Q751D6 Ashbya gossypii AGL230C AGL230Cp and weakly similar to YNR040W uniprot|P53736 Saccharomyces cerevisiae YNR040W Hypothetical ORF; uncharacterized protein 956634 2895889 KLLA0_F10329g Kluyveromyces lactis uncharacterized protein XP_455550.1 955834 R 28985 CDS KLLA0_F10351g 2895890 complement(956981..957400) F 1 NC_006042.1 similar to uniprot|P25372 Saccharomyces cerevisiae YCR083W TRX3 mitochondrial thioredoxin; uncharacterized protein 957400 2895890 KLLA0_F10351g Kluyveromyces lactis uncharacterized protein XP_455551.1 956981 R 28985 CDS KLLA0_F10373g 2895891 957948..958994 F 1 NC_006042.1 some similarities with uniprot|P38141 Saccharomyces cerevisiae YBR240C THI2 Zinc finger protein of the Zn(II)2Cys6 type probable transcriptional activator of thiamine biosynthetic genes; uncharacterized protein 958994 2895891 KLLA0_F10373g Kluyveromyces lactis uncharacterized protein XP_455552.1 957948 D 28985 CDS KLLA0_F10395g 2895892 complement(959120..960238) F 1 NC_006042.1 similar to uniprot|P46672 Saccharomyces cerevisiae YGL105W ARC1 Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p) delivering tRNA to them stimulating catalysis and ensuring their localization to the cytoplasm also binds quadruplex nucleic acids; uncharacterized protein 960238 2895892 KLLA0_F10395g Kluyveromyces lactis uncharacterized protein XP_455553.1 959120 R 28985 CDS KLLA0_F10417g 2895893 961004..962527 F 1 NC_006042.1 similar to uniprot|P38140 Saccharomyces cerevisiae YBR239C Hypothetical ORF; uncharacterized protein 962527 2895893 KLLA0_F10417g Kluyveromyces lactis uncharacterized protein XP_455554.1 961004 D 28985 CDS KLLA0_F10439g 2895722 complement(962683..963111) F 1 NC_006042.1 highly similar to uniprot|P53141 Saccharomyces cerevisiae YGL106W MLC1 Essential light chain for myosin Myo2p may stabilize Myo2p by binding to the neck region may interact with Myo1p Iqg1p and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition; uncharacterized protein 963111 2895722 KLLA0_F10439g Kluyveromyces lactis uncharacterized protein XP_455555.1 962683 R 28985 CDS KLLA0_F10461g 2895723 964030..966024 F 1 NC_006042.1 similar to uniprot|P38330 Saccharomyces cerevisiae YBR238C Hypothetical ORF; uncharacterized protein 966024 2895723 KLLA0_F10461g Kluyveromyces lactis uncharacterized protein XP_455556.1 964030 D 28985 CDS KLLA0_F10483g 2895724 966417..966701 F 1 NC_006042.1 similar to uniprot|P53139 Saccharomyces cerevisiae YGL108C Protein of unknown function; uncharacterized protein 966701 2895724 KLLA0_F10483g Kluyveromyces lactis uncharacterized protein XP_455557.1 966417 D 28985 CDS KLLA0_F10505g 2895725 complement(966736..969174) F 1 NC_006042.1 similar to uniprot|Q754U8 Ashbya gossypii AFL027C PRP5 Pre-mRNA-processing ATP-dependent RNA helicase PRP5 and weakly similar to YBR237W uniprot|P21372 Saccharomyces cerevisiae PRP5 RNA helicase in the DEAD-box family; DEAD-box RNA helicase PRP5 969174 2895725 KLLA0_F10505g Kluyveromyces lactis DEAD-box RNA helicase PRP5 XP_455558.1 966736 R 28985 CDS KLLA0_F10527g 2895726 969804..971084 F 1 NC_006042.1 similar to uniprot|P32783 Saccharomyces cerevisiae YBR236C ABD1 Methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA; mRNA (guanine-N7)-methyltransferase 971084 2895726 KLLA0_F10527g Kluyveromyces lactis mRNA (guanine-N7)-methyltransferase XP_455559.1 969804 D 28985 CDS KLLA0_F10549g 2895727 complement(971178..974453) F 1 NC_006042.1 similar to uniprot|P38329 Saccharomyces cerevisiae YBR235W Hypothetical ORF; uncharacterized protein 974453 2895727 KLLA0_F10549g Kluyveromyces lactis uncharacterized protein XP_455560.1 971178 R 28985 CDS KLLA0_F10571g 2895728 974719..976602 F 1 NC_006042.1 similar to uniprot|P53137 Saccharomyces cerevisiae YGL110C CUE3 Protein of unknown function has a CUE domain that binds ubiquitin which may facilitate intramolecular monoubiquitination; uncharacterized protein 976602 2895728 KLLA0_F10571g Kluyveromyces lactis uncharacterized protein XP_455561.1 974719 D 28985 CDS KLLA0_F10593g 2895729 complement(976698..978008) F 1 NC_006042.1 similar to uniprot|P53136 Saccharomyces cerevisiae YGL111W NSA1 Constituent of 66S pre-ribosomal particles involved in 60S ribosomal subunit biogenesis; ribosome biosynthesis protein NSA1 978008 2895729 KLLA0_F10593g Kluyveromyces lactis ribosome biosynthesis protein NSA1 XP_455562.1 976698 R 28985 CDS KLLA0_F10615g 2895730 978492..979604 F 1 NC_006042.1 highly similar to uniprot|Q754U3 Ashbya gossypii AFL022W AFL022Wp and similar to YBR234C uniprot|P38328 Saccharomyces cerevisiae YBR234C ARC40 Essential subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches; uncharacterized protein 979604 2895730 KLLA0_F10615g Kluyveromyces lactis uncharacterized protein XP_455563.1 978492 D 28985 CDS KLLA0_F10637g 2895731 complement(979795..980052) F 1 NC_006042.1 similar to uniprot|P69850 Saccharomyces cerevisiae YBR233W-A DAD3 Essential protein component of the DASH complex involved in spindle integrity and kinetochore function interacts with Duo1p and Dam1p localizes to intranuclear spindles and kinetochore; uncharacterized protein 980052 2895731 KLLA0_F10637g Kluyveromyces lactis uncharacterized protein XP_455564.1 979795 R 28985 CDS KLLA0_F10659g 2895732 980423..981973 F 1 NC_006042.1 similar to uniprot|P53040 Saccharomyces cerevisiae YGL112C TAF6 Subunit (60 kDa) of TFIID and SAGA complexes; TATA-binding protein-associated factor TAF6 981973 2895732 KLLA0_F10659g Kluyveromyces lactis TATA-binding protein-associated factor TAF6 XP_455565.1 980423 D 28985 CDS KLLA0_F10681g 2895733 complement(982014..983909) F 1 NC_006042.1 weakly similar to uniprot|P53135 Saccharomyces cerevisiae YGL113W SLD3 Protein that interacts with Cdc45p in initiation of DNA replication gene exhibits synthetic lethality with dpb11-1; uncharacterized protein 983909 2895733 KLLA0_F10681g Kluyveromyces lactis uncharacterized protein XP_455566.1 982014 R 28985 CDS KLLA0_F10703g 2895734 complement(984298..985551) F 1 NC_006042.1 similar to uniprot|P38151 Saccharomyces cerevisiae YBR233W; uncharacterized protein 985551 2895734 KLLA0_F10703g Kluyveromyces lactis uncharacterized protein XP_455567.1 984298 R 28985 CDS KLLA0_F10725g 2895073 985843..986790 F 1 NC_006042.1 similar to uniprot|P38326 Saccharomyces cerevisiae YBR231C SWC5 Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin; uncharacterized protein 986790 2895073 KLLA0_F10725g Kluyveromyces lactis uncharacterized protein XP_455568.1 985843 D 28985 CDS KLLA0_F10747g 2895074 complement(986879..989077) F 1 NC_006042.1 similar to uniprot|P53134 Saccharomyces cerevisiae YGL114W Putative member of the oligopeptide transporter (OPT) family of membrane transporters; uncharacterized protein 989077 2895074 KLLA0_F10747g Kluyveromyces lactis uncharacterized protein XP_455569.1 986879 R 28985 CDS KLLA0_F10769g 2895004 complement(989640..990626) F 1 NC_006042.1 uniprot|Q9P869 Kluyveromyces lactis Nuclear protein SNF4; AMP-activated serine/threonine-protein kinase regulatory subunit SNF4 990626 2895004 KLLA0_F10769g Kluyveromyces lactis AMP-activated serine/threonine-protein kinase regulatory subunit SNF4 XP_455570.1 989640 R 28985 CDS KLLA0_F10791g 2895075 complement(991642..993279) F 1 NC_006042.1 similar to uniprot|P26309 Saccharomyces cerevisiae YGL116W CDC20 Cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C) which is required for metaphase/anaphase transition directs ubiquitination of mitotic cyclins Pds1p and other anaphase inhibitors potential Cdc28p substrate; ubiquitin-protein transferase activating protein CDC20 993279 2895075 KLLA0_F10791g Kluyveromyces lactis ubiquitin-protein transferase activating protein CDC20 XP_455571.1 991642 R 28985 CDS KLLA0_F10813g 2895076 complement(993942..995270) F 1 NC_006042.1 similar to uniprot|P53095 Saccharomyces cerevisiae YGL196W Hypothetical ORF; D-serine ammonia-lyase DSD1 995270 2895076 KLLA0_F10813g Kluyveromyces lactis D-serine ammonia-lyase DSD1 XP_455572.1 993942 R 28985 CDS KLLA0_F10835g 2895077 997512..999782 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 999782 2895077 KLLA0_F10835g Kluyveromyces lactis uncharacterized protein XP_455573.1 997512 D 28985 CDS KLLA0_F10857g 2895078 1000899..1001525 F 1 NC_006042.1 weakly similar to uniprot|P40449 Saccharomyces cerevisiae YIL161W Hypothetical ORF; uncharacterized protein 1001525 2895078 KLLA0_F10857g Kluyveromyces lactis uncharacterized protein XP_455574.1 1000899 D 28985 CDS KLLA0_F10879g 2895079 complement(1001626..1002840) F 1 NC_006042.1 similar to uniprot|P27796 Saccharomyces cerevisiae YIL160C POT1 3-ketoacyl-CoA thiolase with broad chain length specificity cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids; acetyl-CoA C-acyltransferase 1002840 2895079 KLLA0_F10879g Kluyveromyces lactis acetyl-CoA C-acyltransferase XP_455575.1 1001626 R 28985 CDS KLLA0_F10912g 2895115 1003827..1007678 F 1 NC_006042.1 some similarities with uniprot|P40450 Saccharomyces cerevisiae YIL159W BNR1 Formin nucleates the formation of linear actin filaments involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables functionally redundant with BNI1; formin BNR1 1007678 2895115 KLLA0_F10912g Kluyveromyces lactis formin BNR1 XP_455577.1 1003827 D 28985 CDS KLLA0_F10934g 2895116 1008727..1009773 F 1 NC_006042.1 weakly similar to uniprot|P36169 Saccharomyces cerevisiae YKR100C SKG1 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; uncharacterized protein 1009773 2895116 KLLA0_F10934g Kluyveromyces lactis uncharacterized protein XP_455578.1 1008727 D 28985 CDS KLLA0_F10956g 2895117 complement(1010089..1010631) F 1 NC_006042.1 similar to uniprot|P40452 Saccharomyces cerevisiae YIL157C FMP35 The authentic non-tagged protein was localized to the mitochondria; uncharacterized protein 1010631 2895117 KLLA0_F10956g Kluyveromyces lactis uncharacterized protein XP_455579.1 1010089 R 28985 CDS KLLA0_F10967g 9487483 join(1010911..1010919,1011074..1011286) F 1 NC_006042.1 highly similar to uniprot|Q2V2P4 Saccharomyces cerevisiae YIL156W-B; mitofissin 1011286 9487483 KLLA0_F10967g Kluyveromyces lactis mitofissin XP_002999430.1 1010911 D 28985 CDS KLLA0_F10978g 2895118 complement(1011479..1013788) F 1 NC_006042.1 similar to uniprot|P22035 Saccharomyces cerevisiae YKR099W BAS1 Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; uncharacterized protein 1013788 2895118 KLLA0_F10978g Kluyveromyces lactis uncharacterized protein XP_455580.1 1011479 R 28985 CDS KLLA0_F11000g 2895119 1014492..1016159 F 1 NC_006042.1 similar to uniprot|Q02724 Saccharomyces cerevisiae YPL020C ULP1 Ubl (ubiquitin-like protein)-specific protease that cleaves Smt3p protein conjugates specifically required for cell cycle progression associates with nucleoporins and may interact with septin rings during telophase; SUMO protease ULP1 1016159 2895119 KLLA0_F11000g Kluyveromyces lactis SUMO protease ULP1 XP_455581.1 1014492 D 28985 CDS KLLA0_F11022g 2895120 complement(1016214..1018880) F 1 NC_006042.1 similar to uniprot|P40965 Saccharomyces cerevisiae YFL003C MSH4 Protein involved in meiotic recombination required for normal levels of crossing over colocalizes with Zip2p to discrete foci on meiotic chromosomes has homology to bacterial MutS protein; MutS family protein MSH4 1018880 2895120 KLLA0_F11022g Kluyveromyces lactis MutS family protein MSH4 XP_455582.1 1016214 R 28985 CDS KLLA0_F11033g 2895121 complement(1018877..1019887) F 1 NC_006042.1 similar to uniprot|P53686 Saccharomyces cerevisiae YPL015C HST2 Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD()-dependent protein deacetylases modulates nucleolar (rDNA) and telomeric silencing possesses NAD()-dependent histone deacetylase activity in vitro; histone deacetylase HST2 1019887 2895121 KLLA0_F11033g Kluyveromyces lactis histone deacetylase HST2 XP_455583.1 1018877 R 28985 CDS KLLA0_F11077g 2895123 1021058..1022797 F 1 NC_006042.1 weakly similar to uniprot|P53918 Saccharomyces cerevisiae YNL125C ESBP6 Protein with similarity to monocarboxylate permeases appears not to be involved in transport of monocarboxylates such as lactate pyruvate or acetate across the plasma membrane; uncharacterized protein 1022797 2895123 KLLA0_F11077g Kluyveromyces lactis uncharacterized protein XP_455584.1 1021058 D 28985 CDS KLLA0_F11099g 2895124 complement(1022939..1024666) F 1 NC_006042.1 weakly similar to uniprot|P40960 Saccharomyces cerevisiae YDR488C PAC11 Dynein intermediate chain acts in the cytoplasmic dynein pathway forms cortical cytoplasmic microtubule capture site with Num1p null mutant is defective in nuclear migration essential in the absence of CIN8; dynein intermediate chain 1024666 2895124 KLLA0_F11099g Kluyveromyces lactis dynein intermediate chain XP_455585.1 1022939 R 28985 CDS KLLA0_F11121g 2895125 1024978..1025856 F 1 NC_006042.1 similar to uniprot|Q6Q558 Saccharomyces cerevisiae YDR489W SLD5 Subunit of the GINS complex (Sld5p Psf1p Psf2p Psf3p) which binds to DNA replication origins and facilitates assembly of the DNA replication machinery; DNA replication protein SLD5 1025856 2895125 KLLA0_F11121g Kluyveromyces lactis DNA replication protein SLD5 XP_455586.1 1024978 D 28985 CDS KLLA0_F11143g 2895126 complement(1026129..1028570) F 1 NC_006042.1 similar to uniprot|P22216 Saccharomyces cerevisiae YPL153C RAD53 Protein kinase required for cell-cycle arrest in response to DNA damage activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; serine/threonine/tyrosine protein kinase RAD53 1028570 2895126 KLLA0_F11143g Kluyveromyces lactis serine/threonine/tyrosine protein kinase RAD53 XP_455587.1 1026129 R 28985 CDS KLLA0_F11165g 2895127 1030159..1031397 F 1 NC_006042.1 similar to uniprot|Q08650 Saccharomyces cerevisiae YOR245C DGA1 Diacylglycerol acyltransferase catalyzes the terminal step of triacylglycerol (TAG) formation acylates diacylglycerol using acyl-CoA as an acyl donor localized to lipid particles; diacylglycerol O-acyltransferase 1031397 2895127 KLLA0_F11165g Kluyveromyces lactis diacylglycerol O-acyltransferase XP_455588.1 1030159 D 28985 CDS KLLA0_F11187g 2895128 1031839..1032921 F 1 NC_006042.1 similar to uniprot|Q12461 Saccharomyces cerevisiae YPL152W RRD2 Resistant to Rapamycin Deletion 2; similar to hosphotyrosyl phosphatase activator (PTPA) from several organisms; peptidylprolyl isomerase RRD2 1032921 2895128 KLLA0_F11187g Kluyveromyces lactis peptidylprolyl isomerase RRD2 XP_455589.1 1031839 D 28985 CDS KLLA0_F11209g 2895129 complement(1033024..1034343) F 1 NC_006042.1 highly similar to uniprot|Q08649 Saccharomyces cerevisiae YOR244W ESA1 Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail required for cell cycle progression; NuA4 histone acetyltransferase complex catalytic subunit ESA1 1034343 2895129 KLLA0_F11209g Kluyveromyces lactis NuA4 histone acetyltransferase complex catalytic subunit ESA1 XP_455590.1 1033024 R 28985 CDS KLLA0_F11231g 2895081 complement(1034708..1036012) F 1 NC_006042.1 similar to uniprot|Q12417 Saccharomyces cerevisiae YPL151C PRP46 Splicing factor that is found in the Cef1p subcomplex of the spliceosome; mRNA splicing protein PRP46 1036012 2895081 KLLA0_F11231g Kluyveromyces lactis mRNA splicing protein PRP46 XP_455591.1 1034708 R 28985 CDS KLLA0_F11253g 2895082 1036274..1038304 F 1 NC_006042.1 similar to uniprot|Q08647 Saccharomyces cerevisiae YOR243C PUS7 pseudouridylates U2 snRNA at position 35; uncharacterized protein 1038304 2895082 KLLA0_F11253g Kluyveromyces lactis uncharacterized protein XP_455592.1 1036274 D 28985 CDS KLLA0_F11275g 2895083 1038770..1039927 F 1 NC_006042.1 weakly similar to uniprot|Q96US5 Saccharomyces cerevisiae YOR242C SSP2 Sporulation SPecific involved in sporulation; uncharacterized protein 1039927 2895083 KLLA0_F11275g Kluyveromyces lactis uncharacterized protein XP_455593.1 1038770 D 28985 CDS KLLA0_F11297g 2895084 complement(1040048..1041529) F 1 NC_006042.1 similar to uniprot|Q08645 Saccharomyces cerevisiae YOR241W MET7 Folylpolyglutamate synthetase catalyzes extension of the glutamate chains of the folate coenzymes required for methionine synthesis and for maintenance of mitochondrial DNA present in both the cytoplasm and mitochondria; tetrahydrofolate synthase 1041529 2895084 KLLA0_F11297g Kluyveromyces lactis tetrahydrofolate synthase XP_455594.1 1040048 R 28985 CDS KLLA0_F11319g 2895085 1042436..1044967 F 1 NC_006042.1 similar to uniprot|Q12152 Saccharomyces cerevisiae YPL150W Hypothetical ORF; non-specific serine/threonine protein kinase 1044967 2895085 KLLA0_F11319g Kluyveromyces lactis non-specific serine/threonine protein kinase XP_455595.1 1042436 D 28985 CDS KLLA0_F11341g 2895086 complement(1045057..1046616) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 1046616 2895086 KLLA0_F11341g Kluyveromyces lactis uncharacterized protein XP_455596.1 1045057 R 28985 CDS KLLA0_F11363g 2895087 1046847..1047662 F 1 NC_006042.1 similar to uniprot|Q12380 Saccharomyces cerevisiae YPL149W ATG5 Conserved autophagy-related protein that undergoes conjugation with Atg12p and then associates with Atg16p to form a cytosolic complex essential for autophagosome formation; uncharacterized protein 1047662 2895087 KLLA0_F11363g Kluyveromyces lactis uncharacterized protein XP_455597.1 1046847 D 28985 CDS KLLA0_F11385g 2895088 complement(1047731..1048795) F 1 NC_006042.1 similar to uniprot|Q08641 Saccharomyces cerevisiae YOR239W/YOR240W; uncharacterized protein 1048795 2895088 KLLA0_F11385g Kluyveromyces lactis uncharacterized protein XP_455598.1 1047731 R 28985 CDS KLLA0_F11396g 2895089 complement(1048734..1049333) F 1 NC_006042.1 no similarity; uncharacterized protein 1049333 2895089 KLLA0_F11396g Kluyveromyces lactis uncharacterized protein XP_455599.1 1048734 R 28985 CDS KLLA0_F11418g 2895090 complement(1049704..1050210) F 1 NC_006042.1 weakly similar to uniprot|Q12036 Saccharomyces cerevisiae YPL148C PPT2 Phosphopantetheine:protein transferase (PPTase) activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation; holo-[acyl-carrier-protein] synthase 1050210 2895090 KLLA0_F11418g Kluyveromyces lactis holo-[acyl-carrier-protein] synthase XP_455600.1 1049704 R 28985 CDS KLLA0_F11440g 2895091 complement(1050417..1051088) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 1051088 2895091 KLLA0_F11440g Kluyveromyces lactis uncharacterized protein XP_455601.1 1050417 R 28985 CDS KLLA0_F11462g 2895092 complement(1051409..1052272) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 1052272 2895092 KLLA0_F11462g Kluyveromyces lactis uncharacterized protein XP_455602.1 1051409 R 28985 CDS KLLA0_F11484g 2895946 1052991..1055528 F 1 NC_006042.1 similar to uniprot|P41909 Saccharomyces cerevisiae YPL147W PXA1 Pxa1p and Pxa2p appear to be subunits of a peroxisomal ATP-binding cassette transporter necessary for transport of long-chain fatty acids into peroxisomes ABC family long-chain fatty acid transporter; ATP-binding cassette long-chain fatty acid transporter PXA1 1055528 2895946 KLLA0_F11484g Kluyveromyces lactis ATP-binding cassette long-chain fatty acid transporter PXA1 XP_455603.1 1052991 D 28985 CDS KLLA0_F11506g 2895947 complement(1055769..1057103) F 1 NC_006042.1 similar to uniprot|Q75BZ3 Ashbya gossypii ACR126W ACR126Wp and some similarites with YPL146C uniprot|Q12080 Saccharomyces cerevisiae YPL146C NOP53 Nucleolar protein involved in biogenesis of the 60S subunit of the ribosome interacts with rRNA processing factors Cbf5p and Nop2p null mutant is viable but growth is severely impaired; uncharacterized protein 1057103 2895947 KLLA0_F11506g Kluyveromyces lactis uncharacterized protein XP_455604.1 1055769 R 28985 CDS KLLA0_F11528g 2895948 complement(1057527..1059788) F 1 NC_006042.1 weakly similar to uniprot|P17629 Saccharomyces cerevisiae YDR138W; uncharacterized protein 1059788 2895948 KLLA0_F11528g Kluyveromyces lactis uncharacterized protein XP_455605.1 1057527 R 28985 CDS KLLA0_F11550g 2895949 1060194..1061885 F 1 NC_006042.1 some similarites with uniprot|Q12500 Saccharomyces cerevisiae YLR114C AVL9 PHO85 Requiring; uncharacterized protein 1061885 2895949 KLLA0_F11550g Kluyveromyces lactis uncharacterized protein XP_455606.1 1060194 D 28985 CDS KLLA0_F11572g 2895950 complement(1061995..1063788) F 1 NC_006042.1 weakly similar to uniprot|P16664 Saccharomyces cerevisiae YDR137W RGP1 Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p; uncharacterized protein 1063788 2895950 KLLA0_F11572g Kluyveromyces lactis uncharacterized protein XP_455607.1 1061995 R 28985 CDS KLLA0_F11638g 2895952 1064635..1065051 F 1 NC_006042.1 similar to uniprot|P38247 Saccharomyces cerevisiae YBR077C SLM4 Protein with a potential role in actin cytoskeleton organization possible component of the TOR nutrient signaling pathway gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase; uncharacterized protein 1065051 2895952 KLLA0_F11638g Kluyveromyces lactis uncharacterized protein XP_455608.1 1064635 D 28985 CDS KLLA0_F11660g 2895953 1065656..1067533 F 1 NC_006042.1 some similarities with uniprot|P32325 Saccharomyces cerevisiae YDR052C DBF4 Regulatory subunit of Cdc7p-Dbf4p kinase complex; protein serine/threonine kinase activating protein DBF4 1067533 2895953 KLLA0_F11660g Kluyveromyces lactis protein serine/threonine kinase activating protein DBF4 XP_455609.1 1065656 D 28985 CDS KLLA0_F11682g 2895954 complement(1068992..1070116) F 1 NC_006042.1 weakly similar to uniprot|Q6Q5F4 Saccharomyces cerevisiae YPR015C Hypothetical ORF; uncharacterized protein 1070116 2895954 KLLA0_F11682g Kluyveromyces lactis uncharacterized protein XP_455610.1 1068992 R 28985 CDS KLLA0_F11704g 2895955 1074845..1077886 F 1 NC_006042.1 similar to uniprot|Q750Z5 Ashbya gossypii AGL208C AGL208Cp and some similarites with YNR067C uniprot|P53753 Saccharomyces cerevisiae; endo-1,3(4)-beta-glucanase 1077886 2895955 KLLA0_F11704g Kluyveromyces lactis endo-1,3(4)-beta-glucanase XP_455611.1 1074845 D 28985 CDS KLLA0_F11726g 2895956 1080554..1082773 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 1082773 2895956 KLLA0_F11726g Kluyveromyces lactis uncharacterized protein XP_455612.1 1080554 D 28985 CDS KLLA0_F11748g 2895957 complement(1082975..1085716) F 1 NC_006042.1 similar to uniprot|P38244 Saccharomyces cerevisiae YBR074W Hypothetical ORF; uncharacterized protein 1085716 2895957 KLLA0_F11748g Kluyveromyces lactis uncharacterized protein XP_455613.1 1082975 R 28985 CDS KLLA0_F11770g 2895958 1086389..1087498 F 1 NC_006042.1 highly similar to uniprot|P32347 Saccharomyces cerevisiae YDR047W HEM12 Uroporphyrinogen decarboxylase catalyzes the fifth step in the heme biosynthetic pathway localizes to both the cytoplasm and nucleus activity inhibited by Cu2 Zn2 Fe2 Fe3 and sulfhydryl-specific reagents; uroporphyrinogen decarboxylase HEM12 1087498 2895958 KLLA0_F11770g Kluyveromyces lactis uroporphyrinogen decarboxylase HEM12 XP_455614.1 1086389 D 28985 CDS KLLA0_F11792g 2895959 1087802..1089667 F 1 NC_006042.1 similar to uniprot|Q66RH0 Saccharomyces cerevisiae YDR049W Hypothetical ORF; uncharacterized protein 1089667 2895959 KLLA0_F11792g Kluyveromyces lactis uncharacterized protein XP_455615.1 1087802 D 28985 CDS KLLA0_F11814g 2895105 complement(1089699..1092494) F 1 NC_006042.1 similar to uniprot|P38086 Saccharomyces cerevisiae YBR073W RDH54 DNA-dependent ATPase stimulates strand exchange by modifying the topology of double-stranded DNA involved in the recombinational repair of double-strand breaks in DNA during mitosis and meiosis proposed to be involved in crossover interference; DNA-dependent ATPase RDH54 1092494 2895105 KLLA0_F11814g Kluyveromyces lactis DNA-dependent ATPase RDH54 XP_455616.1 1089699 R 28985 CDS KLLA0_F11891g 2895109 1093680..1094537 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 1094537 2895109 KLLA0_F11891g Kluyveromyces lactis uncharacterized protein XP_455619.1 1093680 D 28985 CDS KLLA0_F11913g 2895110 complement(1094612..1095373) F 1 NC_006042.1 weakly similar to uniprot|Q04549 Saccharomyces cerevisiae YDR106W ARP10 Actin-related protein; uncharacterized protein 1095373 2895110 KLLA0_F11913g Kluyveromyces lactis uncharacterized protein XP_455620.1 1094612 R 28985 CDS KLLA0_F11935g 2895111 1095626..1097038 F 1 NC_006042.1 similar to uniprot|Q12116 Saccharomyces cerevisiae YDR105C TMS1 Putative membrane protein conserved in mammals; uncharacterized protein 1097038 2895111 KLLA0_F11935g Kluyveromyces lactis uncharacterized protein XP_455621.1 1095626 D 28985 CDS KLLA0_F11957g 2895112 complement(1097165..1098154) F 1 NC_006042.1 highly similar to uniprot|P25453 Saccharomyces cerevisiae YER179W DMC1 Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes homolog of Rad51p and the bacterial RecA protein; recombinase DMC1 1098154 2895112 KLLA0_F11957g Kluyveromyces lactis recombinase DMC1 XP_455622.1 1097165 R 28985 CDS KLLA0_F11979g 2895113 complement(1098706..1100421) F 1 NC_006042.1 uniprot|Q6CKB6 Kluyveromyces lactis KLLA0F11979g ARX1 Probable metalloprotease ARX1; uncharacterized protein 1100421 2895113 KLLA0_F11979g Kluyveromyces lactis uncharacterized protein XP_455623.1 1098706 R 28985 CDS KLLA0_F12001g 2894999 1101429..1102667 F 1 NC_006042.1 uniprot|O13366 Kluyveromyces lactis KLLA0F12001g PDA1 Pyruvate dehydrogenase E1 component alpha subunit, mitochondrial precursor; pyruvate dehydrogenase (acetyl-transferring) subunit E1 alpha 1102667 2894999 KLLA0_F12001g Kluyveromyces lactis pyruvate dehydrogenase (acetyl-transferring) subunit E1 alpha XP_455624.1 1101429 D 28985 CDS KLLA0_F12023g 2895114 1103908..1106148 F 1 NC_006042.1 some similarities with uniprot|P32917 Saccharomyces cerevisiae YDR103W STE5 Scaffold protein that in response to pheromone shuttles from the nucleus to the plasma membrane and assembles kinases Ste11p Ste7p and Fus3p into a specific signaling complex active oligomeric form interacts with Ste4p-Ste18p complex; uncharacterized protein 1106148 2895114 KLLA0_F12023g Kluyveromyces lactis uncharacterized protein XP_455625.1 1103908 D 28985 CDS KLLA0_F12034g 2895094 complement(1106143..1109412) F 1 NC_006042.1 similar to uniprot|Q03868 Saccharomyces cerevisiae YDR104C SPO71 Meiosis-specific protein of unknown function required for spore wall formation during sporulation dispensable for both nuclear divisions during meiosis; uncharacterized protein 1109412 2895094 KLLA0_F12034g Kluyveromyces lactis uncharacterized protein XP_455626.1 1106143 R 28985 CDS KLLA0_F12056g 2895095 complement(1109801..1110886) F 1 NC_006042.1 similar to uniprot|P36156 Saccharomyces cerevisiae YKR076W; S-glutathionyl-(chloro)hydroquinone reductase 1110886 2895095 KLLA0_F12056g Kluyveromyces lactis S-glutathionyl-(chloro)hydroquinone reductase XP_455627.1 1109801 R 28985 CDS KLLA0_F12078g 2895093 complement(1111445..1111867) F 1 NC_006042.1 weakly similar to uniprot|Q03860 Saccharomyces cerevisiae YDR100W TVP15 Tlg2-Vesicle Protein of 15 kDa; integral membrane vesicle protein; uncharacterized protein 1111867 2895093 KLLA0_F12078g Kluyveromyces lactis uncharacterized protein XP_455628.1 1111445 R 28985 CDS KLLA0_F12100g 2895098 complement(1113803..1114555) F 1 NC_006042.1 highly similar to uniprot|P29311 Saccharomyces cerevisiae YER177W BMH1 14-3-3 protein major isoform binds proteins and DNA involved in regulation of many processes including exocytosis and vesicle transport Ras/MAPK signaling during pseudohyphal development rapamycin-sensitive signaling and others; 14-3-3 family protein BMH2 1114555 2895098 KLLA0_F12100g Kluyveromyces lactis 14-3-3 family protein BMH2 XP_455629.1 1113803 R 28985 CDS KLLA0_F12166g 2895097 complement(1116715..1121301) F 1 NC_006042.1 similar to uniprot|Q06554 Saccharomyces cerevisiae YLR247C Hypothetical ORF; E3 ubiquitin-protein ligase IRC20 1121301 2895097 KLLA0_F12166g Kluyveromyces lactis E3 ubiquitin-protein ligase IRC20 XP_455630.1 1116715 R 28985 CDS KLLA0_F12188g 2895100 1122745..1124385 F 1 NC_006042.1 some similarities with uniprot|P38623 Saccharomyces cerevisiae YLR248W RCK2 Protein kinase involved in the response to oxidative stress identified as suppressor of S. pombe cell cycle checkpoint mutations; serine/threonine protein kinase RCK2 1124385 2895100 KLLA0_F12188g Kluyveromyces lactis serine/threonine protein kinase RCK2 XP_455631.1 1122745 D 28985 CDS KLLA0_F12210g 2895099 1125630..1128764 F 1 NC_006042.1 highly similar to uniprot|P16521 Saccharomyces cerevisiae YLR249W YEF3 stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex contains two ABC cassettes and binds and hydrolyses ATP EF-3 (translational elongation factor 3); uncharacterized protein 1128764 2895099 KLLA0_F12210g Kluyveromyces lactis uncharacterized protein XP_455632.1 1125630 D 28985 CDS KLLA0_F12232g 2895101 join(1129199..1129312,1129532..1131337) F 1 NC_006042.1 similar to uniprot|P53541 Saccharomyces cerevisiae YNL012W; uncharacterized protein 1131337 2895101 KLLA0_F12232g Kluyveromyces lactis uncharacterized protein XP_455633.2 1129199 D 28985 CDS KLLA0_F12254g 2895102 1131646..1132320 F 1 NC_006042.1 similar to uniprot|P39931 Saccharomyces cerevisiae YLR250W SSP120 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; uncharacterized protein 1132320 2895102 KLLA0_F12254g Kluyveromyces lactis uncharacterized protein XP_455634.1 1131646 D 28985 CDS KLLA0_F12276g 2895103 complement(1132386..1133648) F 1 NC_006042.1 similar to uniprot|P53980 Saccharomyces cerevisiae YNL011C Hypothetical ORF; uncharacterized protein 1133648 2895103 KLLA0_F12276g Kluyveromyces lactis uncharacterized protein XP_455635.1 1132386 R 28985 CDS KLLA0_F12298g 2894933 1133900..1134574 F 1 NC_006042.1 similar to uniprot|P53981 Saccharomyces cerevisiae YNL010W Hypothetical ORF; uncharacterized protein 1134574 2894933 KLLA0_F12298g Kluyveromyces lactis uncharacterized protein XP_455636.1 1133900 D 28985 CDS KLLA0_F12342g 2894935 1137608..1138855 F 1 NC_006042.1 highly similar to uniprot|P41939 Saccharomyces cerevisiae YLR174W IDP2 Cytosolic NADP-specific isocitrate dehydrogenase catalyzes oxidation of isocitrate to alpha-ketoglutarate levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; isocitrate dehydrogenase (NADP(+)) IDP3 1138855 2894935 KLLA0_F12342g Kluyveromyces lactis isocitrate dehydrogenase (NADP(+)) IDP3 XP_455638.1 1137608 D 28985 CDS KLLA0_F12364g 2894936 1139357..1140241 F 1 NC_006042.1 highly similar to uniprot|P25605 Saccharomyces cerevisiae YCL009C ILV6 Regulatory subunit of acetolactate synthase which catalyzes the first step of branched-chain amino acid biosynthesis enhances activity of the Ilv2p catalytic subunit localizes to mitochondria; acetolactate synthase regulatory subunit 1140241 2894936 KLLA0_F12364g Kluyveromyces lactis acetolactate synthase regulatory subunit XP_455639.1 1139357 D 28985 CDS KLLA0_F12386g 2895001 complement(1140511..1141605) F 1 NC_006042.1 uniprot|P48535 Kluyveromyces lactis RM02 60S RIBOSOMAL PROTEIN L2, MITOCHONDRIAL PRECURSOR; mitochondrial 54S ribosomal protein bL27m 1141605 2895001 KLLA0_F12386g Kluyveromyces lactis mitochondrial 54S ribosomal protein bL27m XP_455640.1 1140511 R 28985 CDS KLLA0_F12408g 2894934 1142235..1142975 F 1 NC_006042.1 similar to uniprot|P25554 Saccharomyces cerevisiae YCL010C SGF29 SaGa associated Factor 29kDa Probable 29kKDa Subunit of SAGA histone acetyltransferase complex; uncharacterized protein 1142975 2894934 KLLA0_F12408g Kluyveromyces lactis uncharacterized protein XP_455641.1 1142235 D 28985 CDS KLLA0_F12430g 2894939 complement(1143594..1151609) F 1 NC_006042.1 similar to uniprot|P33892 Saccharomyces cerevisiae YGL195W GCN1 Positive regulator of the Gcn2p kinase activity forms a complex with Gcn20p proposed to stimulate Gcn2p activation by an uncharged tRNA; uncharacterized protein 1151609 2894939 KLLA0_F12430g Kluyveromyces lactis uncharacterized protein XP_455642.1 1143594 R 28985 CDS KLLA0_F12452g 2894937 complement(1152209..1156510) F 1 NC_006042.1 some similarities with uniprot|P53094 Saccharomyces cerevisiae YGL197W MDS3 Protein with an N-terminal kelch-like domain putative negative regulator of early meiotic gene expression required with Pmd1p for growth under alkaline conditions; uncharacterized protein 1156510 2894937 KLLA0_F12452g Kluyveromyces lactis uncharacterized protein XP_455643.1 1152209 R 28985 CDS KLLA0_F12474g 2894940 complement(1157066..1157704) F 1 NC_006042.1 similar to uniprot|P53093 Saccharomyces cerevisiae YGL198W YIP4 Protein that interacts with Rab GTPases computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport; uncharacterized protein 1157704 2894940 KLLA0_F12474g Kluyveromyces lactis uncharacterized protein XP_455644.1 1157066 R 28985 CDS KLLA0_F12496g 2894941 1159546..1160481 F 1 NC_006042.1 highly similar to uniprot|P32598 Saccharomyces cerevisiae YER133W GLC7 Catalytic subunit of type 1 serine/threonine protein phosphatase involved in many processes including glycogen metabolism sporulation and mitosis interacts with multiple regulatory subunits predominantly isolated with Sds22p; type 1 serine/threonine-protein phosphatase catalytic subunit GLC7 1160481 2894941 KLLA0_F12496g Kluyveromyces lactis type 1 serine/threonine-protein phosphatase catalytic subunit GLC7 XP_455645.1 1159546 D 28985 CDS KLLA0_F12518g 2895799 1161207..1161806 F 1 NC_006042.1 highly similar to uniprot|P32803 Saccharomyces cerevisiae YGL200C EMP24 Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles which function in ER to Golgi transport; uncharacterized protein 1161806 2895799 KLLA0_F12518g Kluyveromyces lactis uncharacterized protein XP_455646.1 1161207 D 28985 CDS KLLA0_F12540g 2895800 1162739..1163116 F 1 NC_006042.1 similar to uniprot|P38204 Saccharomyces cerevisiae YBL025W RRN10 subunit of UAF (upstream activation factor) involved in promoting high level transcription of rDNA Upstream activation factor subunit; uncharacterized protein 1163116 2895800 KLLA0_F12540g Kluyveromyces lactis uncharacterized protein XP_455647.1 1162739 D 28985 CDS KLLA0_F12562g 2895798 1163366..1165480 F 1 NC_006042.1 highly similar to uniprot|P38205 Saccharomyces cerevisiae YBL024W; tRNA (cytosine-C5-)-methyltransferase 1165480 2895798 KLLA0_F12562g Kluyveromyces lactis tRNA (cytosine-C5-)-methyltransferase XP_455648.1 1163366 D 28985 CDS KLLA0_F12584g 2895801 complement(1165710..1168343) F 1 NC_006042.1 highly similar to uniprot|P29469 Saccharomyces cerevisiae YBL023C MCM2 Protein involved in DNA replication component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; MCM DNA helicase complex subunit MCM2 1168343 2895801 KLLA0_F12584g Kluyveromyces lactis MCM DNA helicase complex subunit MCM2 XP_455649.1 1165710 R 28985 CDS KLLA0_F12606g 2895802 1169080..1170159 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 1170159 2895802 KLLA0_F12606g Kluyveromyces lactis uncharacterized protein XP_455650.1 1169080 D 28985 CDS KLLA0_F12628g 2895803 complement(1170396..1171910) F 1 NC_006042.1 similar to uniprot|P38067 Saccharomyces cerevisiae YBR006w UGA2 succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; uncharacterized protein 1171910 2895803 KLLA0_F12628g Kluyveromyces lactis uncharacterized protein XP_455651.1 1170396 R 28985 CDS KLLA0_F12650g 2895804 complement(1172232..1173806) F 1 NC_006042.1 similar to uniprot|P40085 Saccharomyces cerevisiae YER140W Hypothetical ORF; uncharacterized protein 1173806 2895804 KLLA0_F12650g Kluyveromyces lactis uncharacterized protein XP_455652.1 1172232 R 28985 CDS KLLA0_F12672g 2895805 1174064..1174699 F 1 NC_006042.1 similar to uniprot|P40084 Saccharomyces cerevisiae YER139C Hypothetical ORF; RNA polymerase II subunit B1 CTD phosphatase RTR1 1174699 2895805 KLLA0_F12672g Kluyveromyces lactis RNA polymerase II subunit B1 CTD phosphatase RTR1 XP_455653.1 1174064 D 28985 CDS KLLA0_F12694g 2895806 complement(1174812..1175954) F 1 NC_006042.1 weakly similar to uniprot|Q6Q5U4 Saccharomyces cerevisiae YDR065W Hypothetical ORF; uncharacterized protein 1175954 2895806 KLLA0_F12694g Kluyveromyces lactis uncharacterized protein XP_455654.1 1174812 R 28985 CDS KLLA0_F12760g 2895904 1177776..1179224 F 1 NC_006042.1 highly similar to uniprot|P00890 Saccharomyces cerevisiae YNR001C CIT1 Citrate synthase catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate the rate-limiting enzyme of the TCA cycle nuclear encoded mitochondrial protein; citrate (Si)-synthase CIT2 1179224 2895904 KLLA0_F12760g Kluyveromyces lactis citrate (Si)-synthase CIT2 XP_455655.1 1177776 D 28985 CDS KLLA0_F12782g 2895905 1180049..1180777 F 1 NC_006042.1 similar to uniprot|P25349 Saccharomyces cerevisiae YCR004C YCP4 Protein of unknown function, has sequence and structural similarity to flavodoxins; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; flavodoxin-like fold family protein 1180777 2895905 KLLA0_F12782g Kluyveromyces lactis flavodoxin-like fold family protein XP_455656.1 1180049 D 28985 CDS KLLA0_F12804g 2895906 complement(1180909..1182651) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 1182651 2895906 KLLA0_F12804g Kluyveromyces lactis uncharacterized protein XP_455657.1 1180909 R 28985 CDS KLLA0_F12826g 2895907 complement(1183130..1183687) F 1 NC_006042.1 similar to uniprot|P25348 Saccharomyces cerevisiae YCR003W MRPL32 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein bL32m 1183687 2895907 KLLA0_F12826g Kluyveromyces lactis mitochondrial 54S ribosomal protein bL32m XP_455658.1 1183130 R 28985 CDS KLLA0_F12848g 2895908 1184231..1185244 F 1 NC_006042.1 highly similar to uniprot|P25342 Saccharomyces cerevisiae YCR002C CDC10 Component of the septin ring of the mother-bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM; septin CDC10 1185244 2895908 KLLA0_F12848g Kluyveromyces lactis septin CDC10 XP_455659.1 1184231 D 28985 CDS KLLA0_F12892g 2895910 complement(1187526..1189853) F 1 NC_006042.1 highly similar to uniprot|P54861 Saccharomyces cerevisiae YLL001W DNM1 Dynamin-related GTPase required for mitochondrial fission and the maintenance of mitochondrial morphology assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur also participates in endocytosis; dynamin-related GTPase DNM1 1189853 2895910 KLLA0_F12892g Kluyveromyces lactis dynamin-related GTPase DNM1 XP_455660.1 1187526 R 28985 CDS KLLA0_F12914g 2895911 complement(1190220..1191512) F 1 NC_006042.1 similar to uniprot|Q07794 Saccharomyces cerevisiae YLL002W RTT109 Regulator of Ty1 Transposition Regulation of mitochondrial network Killed in Mutagen sensitive to diepoxybutane and/or mitomycin C diepoxybutane and mitomycin C resistance; H3 histone acetyltransferase RTT109 1191512 2895911 KLLA0_F12914g Kluyveromyces lactis H3 histone acetyltransferase RTT109 XP_455661.1 1190220 R 28985 CDS KLLA0_F12936g 2895912 complement(join(1191839..1192421,1192526..1192590)) F 1 NC_006042.1 highly similar to uniprot|P38624 YJL001W Saccharomyces cerevisiae PRE3 20S proteasome beta-type subunit; proteasome core particle subunit beta 1 1192590 2895912 KLLA0_F12936g Kluyveromyces lactis proteasome core particle subunit beta 1 XP_455662.1 1191839 R 28985 CDS KLLA0_F12958g 2895913 complement(1192881..1195799) F 1 NC_006042.1 weakly similar to uniprot|Q12369 Saccharomyces cerevisiae YLL003W SFI1; uncharacterized protein 1195799 2895913 KLLA0_F12958g Kluyveromyces lactis uncharacterized protein XP_455663.1 1192881 R 28985 CDS KLLA0_F12980g 2895914 1196141..1197526 F 1 NC_006042.1 similar to uniprot|P41543 Saccharomyces cerevisiae YJL002C OST1 Alpha subunit of the oligosaccharyltransferase complex of the ER lumen which catalyzes asparagine-linked glycosylation of newly synthesized proteins; dolichyl-diphosphooligosaccharide--protein glycotransferase subunit OST1 1197526 2895914 KLLA0_F12980g Kluyveromyces lactis dolichyl-diphosphooligosaccharide--protein glycotransferase subunit OST1 XP_455664.1 1196141 D 28985 CDS KLLA0_F13002g 2895915 complement(1197689..1199593) F 1 NC_006042.1 similar to uniprot|P54790 Saccharomyces cerevisiae YLL004W ORC3 Subunit of the origin recognition complex which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; origin recognition complex subunit 3 1199593 2895915 KLLA0_F13002g Kluyveromyces lactis origin recognition complex subunit 3 XP_455665.1 1197689 R 28985 CDS KLLA0_F13024g 2895916 complement(1199854..1200210) F 1 NC_006042.1 highly similar to uniprot|P47081 Saccharomyces cerevisiae YJL003W COX16 Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase; uncharacterized protein 1200210 2895916 KLLA0_F13024g Kluyveromyces lactis uncharacterized protein XP_455666.1 1199854 R 28985 CDS KLLA0_F13046g 2895960 1201353..1205492 F 1 NC_006042.1 weakly similar to uniprot|P07248 Saccharomyces cerevisiae YDR216W ADR1 Positive transcriptional regulator controls the expression of ADH2 peroxisomal protein genes and genes required for ethanol glycerol and fatty acid utilization; DNA-binding transcription factor ADR1 1205492 2895960 KLLA0_F13046g Kluyveromyces lactis DNA-binding transcription factor ADR1 XP_455667.1 1201353 D 28985 CDS KLLA0_F13068g 2895961 complement(1205686..1208568) F 1 NC_006042.1 weakly similar to uniprot|P14737 Saccharomyces cerevisiae YDR217C RAD9 DNA damage-dependent checkpoint protein required for cell-cycle arrest in G1/S intra-S and G2/M transmits checkpoint signal by activating Rad53p and Chk1p hyperphosphorylated by Mec1p and Tel1p potential Cdc28p substrate; chromatin-binding protein RAD9 1208568 2895961 KLLA0_F13068g Kluyveromyces lactis chromatin-binding protein RAD9 XP_455668.1 1205686 R 28985 CDS KLLA0_F13090g 2895962 1209397..1210491 F 1 NC_006042.1 some similarities with uniprot|Q05955 Saccharomyces cerevisiae YLR227C ADY4 Component of the meiotic outer plaque; uncharacterized protein 1210491 2895962 KLLA0_F13090g Kluyveromyces lactis uncharacterized protein XP_455669.1 1209397 D 28985 CDS KLLA0_F13112g 2895963 complement(1210588..1211760) F 1 NC_006042.1 similar to uniprot|Q04921 Saccharomyces cerevisiae YDR218C SPR28 Septin-related protein expressed during sporulation; septin SPR28 1211760 2895963 KLLA0_F13112g Kluyveromyces lactis septin SPR28 XP_455670.1 1210588 R 28985 CDS KLLA0_F13134g 2895964 complement(1212025..1213209) F 1 NC_006042.1 similar to uniprot|Q05949 Saccharomyces cerevisiae YLR226W BUR2 Cyclin for the Sgv1p (Bur1p) protein kinase Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II; uncharacterized protein 1213209 2895964 KLLA0_F13134g Kluyveromyces lactis uncharacterized protein XP_455671.1 1212025 R 28985 CDS KLLA0_F13156g 2895965 complement(1213540..1215087) F 1 NC_006042.1 some similarities with uniprot|Q04922 Saccharomyces cerevisiae YDR219C Hypothetical ORF; uncharacterized protein 1215087 2895965 KLLA0_F13156g Kluyveromyces lactis uncharacterized protein XP_455672.1 1213540 R 28985 CDS KLLA0_F13178g 2895966 1215760..1217748 F 1 NC_006042.1 weakly similar to uniprot|Q04924 Saccharomyces cerevisiae YDR221W Hypothetical ORF; uncharacterized protein 1217748 2895966 KLLA0_F13178g Kluyveromyces lactis uncharacterized protein XP_455673.1 1215760 D 28985 CDS KLLA0_F13200g 2895967 1218634..1219926 F 1 NC_006042.1 similar to uniprot|Q04925 YDR222W Saccharomyces cerevisiae Protein of unknown function; uncharacterized protein 1219926 2895967 KLLA0_F13200g Kluyveromyces lactis uncharacterized protein XP_455674.1 1218634 D 28985 CDS KLLA0_F13222g 2895968 1220679..1223633 F 1 NC_006042.1 weakly similar to uniprot|P39520 Saccharomyces cerevisiae YLR223C IFH1 Essential protein with a highly acidic N-terminal domain IFH1 exhibits genetic interactions with FHL1 overexpression interferes with silencing at telomeres and HM loci potential Cdc28p substrate; uncharacterized protein 1223633 2895968 KLLA0_F13222g Kluyveromyces lactis uncharacterized protein XP_455675.1 1220679 D 28985 CDS KLLA0_F13244g 2895969 1224178..1226622 F 1 NC_006042.1 highly similar to uniprot|Q05946 Saccharomyces cerevisiae YLR222C UTP13 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA; uncharacterized protein 1226622 2895969 KLLA0_F13244g Kluyveromyces lactis uncharacterized protein XP_455676.1 1224178 D 28985 CDS KLLA0_F13266g 2895970 1226962..1227573 F 1 NC_006042.1 weakly similar to uniprot|Q05942 Saccharomyces cerevisiae YLR221C RSA3 Protein with a likely role in ribosomal maturation required for accumulation of wild-type levels of large (60S) ribosomal subunits binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus; uncharacterized protein 1227573 2895970 KLLA0_F13266g Kluyveromyces lactis uncharacterized protein XP_455677.1 1226962 D 28985 CDS KLLA0_F13288g 2895971 complement(1227828..1228739) F 1 NC_006042.1 similar to uniprot|P47818 Saccharomyces cerevisiae YLR220W CCC1 Functions in the homeostasis of both calcium and manganese ions Possible transmembrane Ca2 transporter; uncharacterized protein 1228739 2895971 KLLA0_F13288g Kluyveromyces lactis uncharacterized protein XP_455678.1 1227828 R 28985 CDS KLLA0_F13310g 2895972 complement(1229619..1230017) F 1 NC_006042.1 similar to uniprot|P02293 Saccharomyces cerevisiae YDR224C HTB1 One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation meiotic DSB formation and H3 methylation and similar to YBL002W uniprot|P02294 Saccharomyces cerevisiae YBL002W HTB2 One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation; histone H2B 1230017 2895972 KLLA0_F13310g Kluyveromyces lactis histone H2B XP_455679.1 1229619 R 28985 CDS KLLA0_F13332g 2896017 1230744..1231136 F 1 NC_006042.1 similar to uniprot|P04911 Saccharomyces cerevisiae YDR225W HTA1 One of two nearly identical (see also HTA2) histone H2A subtypes core histone required for chromatin assembly and chromosome function DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair acetylated by Nat4p and similar to YBL003C uniprot|P04912 Saccharomyces cerevisiae YBL003C HTA2 One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage- dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p; histone H2A 1231136 2896017 KLLA0_F13332g Kluyveromyces lactis histone H2A XP_455680.1 1230744 D 28985 CDS KLLA0_F13354g 2896018 complement(1231619..1233577) F 1 NC_006042.1 weakly similar to uniprot|Q7LIF4 Saccharomyces cerevisiae YLR219W MSC3 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery msc3 mutants are defective in directing meiotic recombination events to homologous chromatids potential Cdc28p substrate; uncharacterized protein 1233577 2896018 KLLA0_F13354g Kluyveromyces lactis uncharacterized protein XP_455681.1 1231619 R 28985 CDS KLLA0_F13376g 2896019 1234589..1235272 F 1 NC_006042.1 highly similar to uniprot|P07170 Saccharomyces cerevisiae YDR226W ADK1 adenylate kinase; adenylate kinase ADK1 1235272 2896019 KLLA0_F13376g Kluyveromyces lactis adenylate kinase ADK1 XP_455682.1 1234589 D 28985 CDS KLLA0_F13398g 2896020 1236895..1239399 F 1 NC_006042.1 no similarity; uncharacterized protein 1239399 2896020 KLLA0_F13398g Kluyveromyces lactis uncharacterized protein XP_455683.1 1236895 D 28985 CDS KLLA0_F13420g 2896021 1240135..1244145 F 1 NC_006042.1 uniprot|O59904 Kluyveromyces lactis SIR4 Silent information regulator 4; chromatin-silencing protein SIR4 1244145 2896021 KLLA0_F13420g Kluyveromyces lactis chromatin-silencing protein SIR4 XP_455684.1 1240135 D 28985 CDS KLLA0_F13442g 2896022 complement(1244416..1246179) F 1 NC_006042.1 similar to uniprot|P39081 Saccharomyces cerevisiae YDR228C PCF11 mRNA 3' end processing factor essential component of cleavage and polyadenylation factor IA (CF IA) involved in pre-mRNA 3' end processing and in transcription termination binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); uncharacterized protein 1246179 2896022 KLLA0_F13442g Kluyveromyces lactis uncharacterized protein XP_455685.1 1244416 R 28985 CDS KLLA0_F13464g 2896023 1246646..1247548 F 1 NC_006042.1 highly similar to uniprot|P38988 Saccharomyces cerevisiae YDL198C GGC1 Mitochondrial GTP/GDP transporter essential for mitochondrial genome maintenance has a role in mitochondrial iron transport member of the mitochondrial carrier family (putative) mitochondrial carrier protein; uncharacterized protein 1247548 2896023 KLLA0_F13464g Kluyveromyces lactis uncharacterized protein XP_455686.1 1246646 D 28985 CDS KLLA0_F13486g 2896024 complement(1247633..1248457) F 1 NC_006042.1 some similarities with uniprot|P34246 Saccharomyces cerevisiae YKL098W Hypothetical ORF; uncharacterized protein 1248457 2896024 KLLA0_F13486g Kluyveromyces lactis uncharacterized protein XP_455687.1 1247633 R 28985 CDS KLLA0_F13508g 2896025 1248753..1249502 F 1 NC_006042.1 similar to uniprot|P34247 Saccharomyces cerevisiae YKL099C UTP11 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; rRNA-processing protein UTP11 1249502 2896025 KLLA0_F13508g Kluyveromyces lactis rRNA-processing protein UTP11 XP_455688.1 1248753 D 28985 CDS KLLA0_F13530g 2894943 1251162..1252289 F 1 NC_006042.1 uniprot|P49385 Kluyveromyces lactis ADH4 Alcohol dehydrogenase IV, mitochondrial precursor; alcohol dehydrogenase ADH3 1252289 2894943 KLLA0_F13530g Kluyveromyces lactis alcohol dehydrogenase ADH3 XP_455689.1 1251162 D 28985 CDS KLLA0_F13552g 2895807 complement(1252906..1256709) F 1 NC_006042.1 weakly similar to uniprot|P34244 Saccharomyces cerevisiae YKL101W HSL1 Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints associates with the assembled septin filament required along with Hsl7p for bud neck recruitment phosphorylation and degradation of Swe1p; protein kinase HSL1 1256709 2895807 KLLA0_F13552g Kluyveromyces lactis protein kinase HSL1 XP_455690.1 1252906 R 28985 CDS KLLA0_F13574g 2895808 1257682..1259241 F 1 NC_006042.1 similar to uniprot|P14904 YKL103C Saccharomyces cerevisiae LAP4 Vacuolar aminopeptidase; metalloaminopeptidase APE1 1259241 2895808 KLLA0_F13574g Kluyveromyces lactis metalloaminopeptidase APE1 XP_455691.1 1257682 D 28985 CDS KLLA0_F13596g 2895809 1259744..1261858 F 1 NC_006042.1 highly similar to uniprot|P14742 Saccharomyces cerevisiae YKL104C GFA1 Glutamine-fructose-6-phosphate amidotransferase catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1 1261858 2895809 KLLA0_F13596g Kluyveromyces lactis glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1 XP_455692.1 1259744 D 28985 CDS KLLA0_F13618g 2895810 1262308..1264575 F 1 NC_006042.1 some similarities with uniprot|Q04279 Saccharomyces cerevisiae YMR086W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and uniprot|P34250 Saccharomyces cerevisiae YKL105C; uncharacterized protein 1264575 2895810 KLLA0_F13618g Kluyveromyces lactis uncharacterized protein XP_455693.1 1262308 D 28985 CDS KLLA0_F13640g 2895811 complement(1264781..1266037) F 1 NC_006042.1 similar to uniprot|Q01802 Saccharomyces cerevisiae YKL106W AAT1 Mitochondrial aspartate aminotransferase catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis; aspartate transaminase AAT1 1266037 2895811 KLLA0_F13640g Kluyveromyces lactis aspartate transaminase AAT1 XP_455694.1 1264781 R 28985 CDS KLLA0_F13662g 2895812 1266539..1267276 F 1 NC_006042.1 similar to uniprot|Q04299 Saccharomyces cerevisiae YMR087W Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose may have a role in tRNA splicing contains an A1pp domain; uncharacterized protein 1267276 2895812 KLLA0_F13662g Kluyveromyces lactis uncharacterized protein XP_455695.1 1266539 D 28985 CDS KLLA0_F13684g 2895813 complement(1267367..1269082) F 1 NC_006042.1 similar to uniprot|Q04301 Saccharomyces cerevisiae YMR088C VBA1 Permease of basic amino acids in the vacuolar membrane; uncharacterized protein 1269082 2895813 KLLA0_F13684g Kluyveromyces lactis uncharacterized protein XP_455696.1 1267367 R 28985 CDS KLLA0_F13706g 2895814 complement(1269550..1272078) F 1 NC_006042.1 similar to uniprot|P40341 Saccharomyces cerevisiae YMR089C YTA12 Component with Afg3p of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes; m-AAA protease subunit YTA12 1272078 2895814 KLLA0_F13706g Kluyveromyces lactis m-AAA protease subunit YTA12 XP_455697.1 1269550 R 28985 CDS KLLA0_F13728g 2895815 complement(1272497..1273759) F 1 NC_006042.1 similar to uniprot|P32832 Saccharomyces cerevisiae YMR091C NPL6 Nuclear protein that may have a role in nuclear protein import; uncharacterized protein 1273759 2895815 KLLA0_F13728g Kluyveromyces lactis uncharacterized protein XP_455698.1 1272497 R 28985 CDS KLLA0_F13750g 2895816 complement(1274110..1275972) F 1 NC_006042.1 similar to uniprot|P46680 Saccharomyces cerevisiae YMR092C AIP1 Actin cortical patch component probable binding site on actin lies on front surface of subdomains 3 and 4; uncharacterized protein 1275972 2895816 KLLA0_F13750g Kluyveromyces lactis uncharacterized protein XP_455699.1 1274110 R 28985 CDS KLLA0_F13772g 2895817 1276532..1278094 F 1 NC_006042.1 highly similar to uniprot|Q04305 Saccharomyces cerevisiae YMR093W UTP15 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; snoRNA-binding rRNA-processing protein UTP15 1278094 2895817 KLLA0_F13772g Kluyveromyces lactis snoRNA-binding rRNA-processing protein UTP15 XP_455700.1 1276532 D 28985 CDS KLLA0_F13794g 2895818 complement(1278244..1279446) F 1 NC_006042.1 similar to uniprot|Q75DR2 Ashbya gossypii ABL045W and weakly similar to YKL108W uniprot|P34252 Saccharomyces cerevisiae SLD2 Protein required for DNA replication; uncharacterized protein 1279446 2895818 KLLA0_F13794g Kluyveromyces lactis uncharacterized protein XP_455701.1 1278244 R 28985 CDS KLLA0_F13816g 2895819 1279517..1280686 F 1 NC_006042.1 weakly similar to uniprot|P35203 Saccharomyces cerevisiae YMR094W CTF13 Subunit of the CBF3 complex which binds to the CDE III element of centromeres bending the DNA upon binding and may be involved in sister chromatid cohesion during mitosis; uncharacterized protein 1280686 2895819 KLLA0_F13816g Kluyveromyces lactis uncharacterized protein XP_455702.1 1279517 D 28985 CDS KLLA0_F13838g 2895820 complement(1281316..1283247) F 1 NC_006042.1 uniprot|O94233 Kluyveromyces lactis HAP4; transcription factor HAP4 1283247 2895820 KLLA0_F13838g Kluyveromyces lactis transcription factor HAP4 XP_455703.1 1281316 R 28985 CDS KLLA0_F13860g 2894877 1284278..1284697 F 1 NC_006042.1 similar to uniprot|P42949 Saccharomyces cerevisiae YJL104W; import motor complex subunit PAM16 1284697 2894877 KLLA0_F13860g Kluyveromyces lactis import motor complex subunit PAM16 XP_455704.1 1284278 D 28985 CDS KLLA0_F13882g 2894878 1286151..1287647 F 1 NC_006042.1 similar to uniprot|P36119 Saccharomyces cerevisiae YKR023W Hypothetical ORF; uncharacterized protein 1287647 2894878 KLLA0_F13882g Kluyveromyces lactis uncharacterized protein XP_455705.1 1286151 D 28985 CDS KLLA0_F13904g 2894879 complement(1287758..1289497) F 1 NC_006042.1 similar to uniprot|P42950 Saccharomyces cerevisiae YJL103C Hypothetical ORF; uncharacterized protein 1289497 2894879 KLLA0_F13904g Kluyveromyces lactis uncharacterized protein XP_455706.1 1287758 R 28985 CDS KLLA0_F13926g 2894880 complement(1290006..1292228) F 1 NC_006042.1 similar to uniprot|P36120 Saccharomyces cerevisiae YKR024C DBP7 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; uncharacterized protein 1292228 2894880 KLLA0_F13926g Kluyveromyces lactis uncharacterized protein XP_455707.1 1290006 R 28985 CDS KLLA0_F13948g 2894881 1292876..1293634 F 1 NC_006042.1 similar to uniprot|P36121 Saccharomyces cerevisiae YKR025W RPC37 RNA polymerase III subunit C37; DNA-directed RNA polymerase III subunit C37 1293634 2894881 KLLA0_F13948g Kluyveromyces lactis DNA-directed RNA polymerase III subunit C37 XP_455708.1 1292876 D 28985 CDS KLLA0_F13970g 2894882 complement(1293695..1294615) F 1 NC_006042.1 highly similar to uniprot|P14741 Saccharomyces cerevisiae YKR026C GCN3 Alpha subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2; translation initiation factor eIF2B subunit alpha 1294615 2894882 KLLA0_F13970g Kluyveromyces lactis translation initiation factor eIF2B subunit alpha XP_455709.2 1293695 R 28985 CDS KLLA0_F13981g 9487502 complement(1294716..1294949) F 1 NC_006042.1 no similarity; uncharacterized protein 1294949 9487502 KLLA0_F13981g Kluyveromyces lactis uncharacterized protein XP_002999431.1 1294716 R 28985 CDS KLLA0_F13992g 2894883 1295129..1297531 F 1 NC_006042.1 similar to uniprot|P39677 Saccharomyces cerevisiae YJL102W MEF2 mitochondrial elongation factor G-like protein; uncharacterized protein 1297531 2894883 KLLA0_F13992g Kluyveromyces lactis uncharacterized protein XP_455710.1 1295129 D 28985 CDS KLLA0_F14058g 2894885 complement(1298078..1300075) F 1 NC_006042.1 similar to uniprot|P32477 Saccharomyces cerevisiae YJL101C GSH1 Gamma glutamylcysteine synthetase catalyzes the first step in the gamma-glutamyl cycle for glutathione (GSH) biosynthesis expression induced by oxidants cadmium and mercury; glutamate--cysteine ligase 1300075 2894885 KLLA0_F14058g Kluyveromyces lactis glutamate--cysteine ligase XP_455711.1 1298078 R 28985 CDS KLLA0_F14080g 2894886 1300876..1302420 F 1 NC_006042.1 similar to uniprot|P42951 Saccharomyces cerevisiae YJL100W LSB6 Phosphatidylinositol 4-kinase that binds Las17p which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; 1-phosphatidylinositol 4-kinase LSB6 1302420 2894886 KLLA0_F14080g Kluyveromyces lactis 1-phosphatidylinositol 4-kinase LSB6 XP_455712.1 1300876 D 28985 CDS KLLA0_F14102g 2894887 1302743..1304893 F 1 NC_006042.1 similar to uniprot|P36122 Saccharomyces cerevisiae YKR027W FMP50 The authentic non-tagged protein was localized to the mitochondria and uniprot|P40955 Saccharomyces cerevisiae YJL099w CHS6 chitin biosynthesis protein; uncharacterized protein 1304893 2894887 KLLA0_F14102g Kluyveromyces lactis uncharacterized protein XP_455713.1 1302743 D 28985 CDS KLLA0_F14124g 2894888 1305690..1308992 F 1 NC_006042.1 similar to uniprot|P36123 Saccharomyces cerevisiae or to YJL098W uniprot|P40856 Saccharomyces cerevisiae YJL098W; uncharacterized protein 1308992 2894888 KLLA0_F14124g Kluyveromyces lactis uncharacterized protein XP_455714.1 1305690 D 28985 CDS KLLA0_F14146g 2894889 1309358..1310002 F 1 NC_006042.1 similar to uniprot|P40857 Saccharomyces cerevisiae YJL097W Protein required for cell viability; enoyl-CoA hydratase PHS1 1310002 2894889 KLLA0_F14146g Kluyveromyces lactis enoyl-CoA hydratase PHS1 XP_455715.1 1309358 D 28985 CDS KLLA0_F14168g 2894890 1310321..1310803 F 1 NC_006042.1 some similarities with uniprot|P40858 Saccharomyces cerevisiae YJL096W MRPL49 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein bL21m 1310803 2894890 KLLA0_F14168g Kluyveromyces lactis mitochondrial 54S ribosomal protein bL21m XP_455716.1 1310321 D 28985 CDS KLLA0_F14190g 2894921 1311121..1315137 F 1 NC_006042.1 uniprot|O60030 Kluyveromyces lactis BCK1 MAP kinase kinase kinase; mitogen-activated protein kinase kinase kinase BCK1 1315137 2894921 KLLA0_F14190g Kluyveromyces lactis mitogen-activated protein kinase kinase kinase BCK1 XP_455717.1 1311121 D 28985 CDS KLLA0_F14212g 2894922 complement(1315326..1317212) F 1 NC_006042.1 weakly similar to uniprot|P40310 Saccharomyces cerevisiae YJL093C TOK1 Target Of K1 Killer Toxin outward-rectifier potassium channel; uncharacterized protein 1317212 2894922 KLLA0_F14212g Kluyveromyces lactis uncharacterized protein XP_455718.1 1315326 R 28985 CDS KLLA0_F14234g 2894923 1317691..1320885 F 1 NC_006042.1 similar to uniprot|P12954 Saccharomyces cerevisiae YJL092W HPR5 DNA helicase and DNA-dependent ATPase involved in DNA repair required for proper timing of commitment to meiotic recombination and the transition from Meiosis I to Meiosis II potential Cdc28p substrate; DNA helicase SRS2 1320885 2894923 KLLA0_F14234g Kluyveromyces lactis DNA helicase SRS2 XP_455719.1 1317691 D 28985 CDS KLLA0_F14256g 2894924 1321231..1324131 F 1 NC_006042.1 similar to uniprot|P12954 Saccharomyces cerevisiae YJL092W HPR5 DNA helicase and DNA-dependent ATPase involved in DNA repair required for proper timing of commitment to meiotic recombination and the transition from Meiosis I to Meiosis II potential Cdc28p substrate; uncharacterized protein 1324131 2894924 KLLA0_F14256g Kluyveromyces lactis uncharacterized protein XP_455720.1 1321231 D 28985 CDS KLLA0_F14278g 2894925 complement(1324216..1325556) F 1 NC_006042.1 similar to uniprot|P47026 Saccharomyces cerevisiae YJL091C GWT1 Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI) an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors; glucosaminyl-phosphotidylinositol O-acyltransferase 1325556 2894925 KLLA0_F14278g Kluyveromyces lactis glucosaminyl-phosphotidylinositol O-acyltransferase XP_455721.1 1324216 R 28985 CDS KLLA0_F14300g 2894926 complement(1325862..1327871) F 1 NC_006042.1 similar to uniprot|P47027 Saccharomyces cerevisiae YJL090C DPB11 Essential BRCT repeat protein required on the prereplicative complex at replication origins for loading DNA polymerases to initiate DNA synthesis also required for S/M checkpoint control; protein kinase activating protein DPB11 1327871 2894926 KLLA0_F14300g Kluyveromyces lactis protein kinase activating protein DPB11 XP_455722.1 1325862 R 28985 CDS KLLA0_F14322g 2894927 1328925..1331078 F 1 NC_006042.1 uniprot|Q7Z8R2 Kluyveromyces lactis Sip4 protein; uncharacterized protein 1331078 2894927 KLLA0_F14322g Kluyveromyces lactis uncharacterized protein XP_455723.1 1328925 D 28985 CDS KLLA0_F14344g 2894928 1331407..1332261 F 1 NC_006042.1 weakly similar to uniprot|P36118 Saccharomyces cerevisiae YKR022C Protein required for cell viability; uncharacterized protein 1332261 2894928 KLLA0_F14344g Kluyveromyces lactis uncharacterized protein XP_455724.1 1331407 D 28985 CDS KLLA0_F14366g 2894929 1332595..1333599 F 1 NC_006042.1 similar to uniprot|P05150 YJL088W Saccharomyces cerevisiae ARG3 Ornithine carbamoyltransferase; ornithine carbamoyltransferase 1333599 2894929 KLLA0_F14366g Kluyveromyces lactis ornithine carbamoyltransferase XP_455725.1 1332595 D 28985 CDS KLLA0_F14399g 2894982 complement(1333743..1336184) F 1 NC_006042.1 similar to uniprot|P09880 YJL087C Saccharomyces cerevisiae TRL1 tRNA ligase; tRNA ligase 1336184 2894982 KLLA0_F14399g Kluyveromyces lactis tRNA ligase XP_455727.1 1333743 R 28985 CDS KLLA0_F14421g 2894983 1336663..1338522 F 1 NC_006042.1 similar to uniprot|P19658 YJL085W Saccharomyces cerevisiae EXO70 Essential 70kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p); GTP-Rho binding exocyst subunit EXO70 1338522 2894983 KLLA0_F14421g Kluyveromyces lactis GTP-Rho binding exocyst subunit EXO70 XP_455728.1 1336663 D 28985 CDS KLLA0_F14443g 2894984 complement(1338526..1341213) F 1 NC_006042.1 some similarities with uniprot|P47029 Saccharomyces cerevisiae YJL084C Cytoplasmic protein of unknown function that interacts with Pcl7p phosphorylated in vitro potential Cdc28p substrate; uncharacterized protein 1341213 2894984 KLLA0_F14443g Kluyveromyces lactis uncharacterized protein XP_455729.1 1338526 R 28985 CDS KLLA0_F14465g 2894985 1341764..1344067 F 1 NC_006042.1 similar to uniprot|P14736 Saccharomyces cerevisiae YER162C RAD4 Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair subunit of Nuclear Excision Repair Factor 2 (NEF2) homolog of human XPC protein; uncharacterized protein 1344067 2894985 KLLA0_F14465g Kluyveromyces lactis uncharacterized protein XP_455730.1 1341764 D 28985 CDS KLLA0_F14487g 2894986 1344298..1345206 F 1 NC_006042.1 weakly similar to uniprot|P06843 Saccharomyces cerevisiae YER161c SPT2 multifunctional HMG-like chromatin protein; uncharacterized protein 1345206 2894986 KLLA0_F14487g Kluyveromyces lactis uncharacterized protein XP_455731.1 1344298 D 28985 CDS KLLA0_F14509g 2894987 complement(1345334..1347889) F 1 NC_006042.1 similar to uniprot|P38966 Saccharomyces cerevisiae YDR089W Hypothetical ORF; uncharacterized protein 1347889 2894987 KLLA0_F14509g Kluyveromyces lactis uncharacterized protein XP_455732.1 1345334 R 28985 CDS KLLA0_F14531g 2894988 1349155..1350180 F 1 NC_006042.1 weakly similar to uniprot|Q02775 Saccharomyces cerevisiae YDR088C SLU7 Protein involved in 3' splice site choices acts in concert with Prp18p during the 2nd step of splicing; mRNA splicing protein SLU7 1350180 2894988 KLLA0_F14531g Kluyveromyces lactis mRNA splicing protein SLU7 XP_455733.1 1349155 D 28985 CDS KLLA0_F14553g 2894989 1350504..1351637 F 1 NC_006042.1 similar to uniprot|P53294 Saccharomyces cerevisiae YGR169C PUS6 RNA:Psi-synthase and weakly similar to YOL066C uniprot|Q12362 Saccharomyces cerevisiae YOL066C RIB2 DRAP deaminase, catalyzes the third step of the riboflavin biosynthesis pathway; N-terminus has sequence similarity to RNA:pseudouridine synthases; uncharacterized protein 1351637 2894989 KLLA0_F14553g Kluyveromyces lactis uncharacterized protein XP_455734.1 1350504 D 28985 CDS KLLA0_F14575g 2894990 complement(1351796..1354351) F 1 NC_006042.1 some similarities with uniprot|P47068 Saccharomyces cerevisiae YJL020C/YJL021C BBC1 Protein possibly involved in assembly of actin patches; uncharacterized protein 1354351 2894990 KLLA0_F14575g Kluyveromyces lactis uncharacterized protein XP_455735.1 1351796 R 28985 CDS KLLA0_F14597g 2894991 1354637..1355674 F 1 NC_006042.1 weakly similar to uniprot|P53293 Saccharomyces cerevisiae YGR168C Hypothetical ORF; uncharacterized protein 1355674 2894991 KLLA0_F14597g Kluyveromyces lactis uncharacterized protein XP_455736.1 1354637 D 28985 CDS KLLA0_F14619g 2894992 complement(1355858..1356547) F 1 NC_006042.1 similar to uniprot|P17891 Saccharomyces cerevisiae YGR167W CLC1 Clathrin light chain; uncharacterized protein 1356547 2894992 KLLA0_F14619g Kluyveromyces lactis uncharacterized protein XP_455737.1 1355858 R 28985 CDS KLLA0_F14641g 2894993 complement(1356788..1358071) F 1 NC_006042.1 weakly similar to uniprot|P32893 Saccharomyces cerevisiae YGR166W KRE11 Protein involved in biosynthesis of cell wall beta-glucans subunit of the TRAPP (transport protein particle) complex which is involved in the late steps of endoplasmic reticulum to Golgi transport; uncharacterized protein 1358071 2894993 KLLA0_F14641g Kluyveromyces lactis uncharacterized protein XP_455738.1 1356788 R 28985 CDS KLLA0_F14663g 2895003 complement(1358439..1360451) F 1 NC_006042.1 uniprot|P33294 Kluyveromyces lactis KLLA0F14663g SIR2 NAD-dependent histone deacetylase SIR2; uncharacterized protein 1360451 2895003 KLLA0_F14663g Kluyveromyces lactis uncharacterized protein XP_455739.1 1358439 R 28985 CDS KLLA0_F14685g 2894994 complement(1361016..1361636) F 1 NC_006042.1 similar to uniprot|P32607 Saccharomyces cerevisiae YOL067C RTG1 Transcription factor (bHLH) involved in interorganelle communication between mitochondria peroxisomes and nucleus; uncharacterized protein 1361636 2894994 KLLA0_F14685g Kluyveromyces lactis uncharacterized protein XP_455740.1 1361016 R 28985 CDS KLLA0_F14707g 2894995 1361964..1363268 F 1 NC_006042.1 highly similar to uniprot|P40327 Saccharomyces cerevisiae YDL007W RPT2 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates required for normal peptide hydrolysis by the core 20S particle; proteasome regulatory particle base subunit RPT2 1363268 2894995 KLLA0_F14707g Kluyveromyces lactis proteasome regulatory particle base subunit RPT2 XP_455741.1 1361964 D 28985 CDS KLLA0_F14729g 2894779 1363888..1364736 F 1 NC_006042.1 highly similar to uniprot|P35182 Saccharomyces cerevisiae YDL006W PTC1 Type 2C protein phosphatase (PP2C) inactivates the osmosensing MAPK cascade by dephosphorylating Hog1p mutation delays mitochondrial inheritance deletion reveals defects in precursor tRNA splicing sporulation and cell separation; type 2C protein phosphatase PTC1 1364736 2894779 KLLA0_F14729g Kluyveromyces lactis type 2C protein phosphatase PTC1 XP_455742.1 1363888 D 28985 CDS KLLA0_F14751g 2894780 complement(1364995..1365837) F 1 NC_006042.1 weakly similar to uniprot|Q12124 Saccharomyces cerevisiae YDL005C MED2 RNA Polymerase II transcriptional regulation mediator Stoichiometric member of mediator complex; uncharacterized protein 1365837 2894780 KLLA0_F14751g Kluyveromyces lactis uncharacterized protein XP_455743.1 1364995 R 28985 CDS KLLA0_F14773g 2894944 1366502..1366981 F 1 NC_006042.1 uniprot|P78700 Kluyveromyces lactis KLLA0F14773g ATP16 ATP synthase delta chain, mitochondrial precursor; F1F0 ATP synthase subunit delta 1366981 2894944 KLLA0_F14773g Kluyveromyces lactis F1F0 ATP synthase subunit delta XP_455744.1 1366502 D 28985 CDS KLLA0_F14795g 2894781 1368194..1369996 F 1 NC_006042.1 similar to uniprot|Q12158 Saccharomyces cerevisiae YDL003W MCD1 Essential protein required for sister chromatid cohesion in mitosis and meiosis; kleisin alpha 1369996 2894781 KLLA0_F14795g Kluyveromyces lactis kleisin alpha XP_455745.1 1368194 D 28985 CDS KLLA0_F14817g 2894782 complement(1370109..1372292) F 1 NC_006042.1 similar to uniprot|Q05468 Saccharomyces cerevisiae YDR333C Hypothetical ORF; uncharacterized protein 1372292 2894782 KLLA0_F14817g Kluyveromyces lactis uncharacterized protein XP_455746.1 1370109 R 28985 CDS KLLA0_F14839g 2894783 1372634..1373779 F 1 NC_006042.1 similar to uniprot|P38803 Saccharomyces cerevisiae YHR085W IPI1 Protein of unknown function essential for viability may be involved in rRNA processing; uncharacterized protein 1373779 2894783 KLLA0_F14839g Kluyveromyces lactis uncharacterized protein XP_455747.1 1372634 D 28985 CDS KLLA0_F14861g 2894784 1375042..1376811 F 1 NC_006042.1 some similarities with uniprot|Q00539 Saccharomyces cerevisiae YHR086W NAM8 RNA binding protein component of the U1 snRNP protein; uncharacterized protein 1376811 2894784 KLLA0_F14861g Kluyveromyces lactis uncharacterized protein XP_455748.1 1375042 D 28985 CDS KLLA0_F14905g 2894786 1378784..1379626 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 1379626 2894786 KLLA0_F14905g Kluyveromyces lactis uncharacterized protein XP_455750.1 1378784 D 28985 CDS KLLA0_F14916g 9487323 complement(1380006..1380278) F 1 NC_006042.1 similar to uniprot|Q3E772 Saccharomyces cerevisiae YGR169C-A; uncharacterized protein 1380278 9487323 KLLA0_F14916g Kluyveromyces lactis uncharacterized protein XP_002999432.1 1380006 R 28985 CDS KLLA0_F14927g 2894787 1381250..1384360 F 1 NC_006042.1 weakly similar to uniprot|P53037 Saccharomyces cerevisiae YGR170W PSD2 Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes converts phosphatidylserine to phosphatidylethanolamine; phosphatidylserine decarboxylase 2 1384360 2894787 KLLA0_F14927g Kluyveromyces lactis phosphatidylserine decarboxylase 2 XP_455751.1 1381250 D 28985 CDS KLLA0_F14949g 2894788 join(1384656..1384681,1384759..1386121) F 1 NC_006042.1 similar to uniprot|P46957 Saccharomyces cerevisiae YJR006W HYS2 DNA polymerase III (delta) 55 kDa subunit essential for cell viability involved in DNA replication and DNA repair; DNA-directed DNA polymerase delta subunit POL31 1386121 2894788 KLLA0_F14949g Kluyveromyces lactis DNA-directed DNA polymerase delta subunit POL31 XP_455752.2 1384656 D 28985 CDS KLLA0_F14971g 2894789 complement(1386169..1387875) F 1 NC_006042.1 similar to uniprot|P22438 Saccharomyces cerevisiae YGR171C MSM1 Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p; methionine--tRNA ligase MSM1 1387875 2894789 KLLA0_F14971g Kluyveromyces lactis methionine--tRNA ligase MSM1 XP_455753.1 1386169 R 28985 CDS KLLA0_F14993g 2894790 complement(1388151..1389260) F 1 NC_006042.1 highly similar to uniprot|P53295 Saccharomyces cerevisiae YGR173W; uncharacterized protein 1389260 2894790 KLLA0_F14993g Kluyveromyces lactis uncharacterized protein XP_455754.1 1388151 R 28985 CDS KLLA0_F15015g 2894791 1389925..1390728 F 1 NC_006042.1 similar to uniprot|P53039 Saccharomyces cerevisiae YGR172C YIP1 Golgi integral membrane protein binds to the transport GTPases Ypt1p and Ypt31p; transporter YIP1 1390728 2894791 KLLA0_F15015g Kluyveromyces lactis transporter YIP1 XP_455755.1 1389925 D 28985 CDS KLLA0_F15037g 2896043 1391311..1392204 F 1 NC_006042.1 weakly similar to uniprot|P29509 Saccharomyces cerevisiae YDR353W TRR1 Thioredoxin reductase; uncharacterized protein 1392204 2896043 KLLA0_F15037g Kluyveromyces lactis uncharacterized protein XP_455756.1 1391311 D 28985 CDS KLLA0_F15103g 2896045 1393721..1394926 F 1 NC_006042.1 highly similar to uniprot|P09938 Saccharomyces cerevisiae YJL026W RNR2 Ribonucleotide-diphosphate reductase (RNR) small subunit the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; ribonucleotide-diphosphate reductase subunit RNR4 1394926 2896045 KLLA0_F15103g Kluyveromyces lactis ribonucleotide-diphosphate reductase subunit RNR4 XP_455757.1 1393721 D 28985 CDS KLLA0_F15136g 2896047 1395315..1396466 F 1 NC_006042.1 some similarities with uniprot|P53298 Saccharomyces cerevisiae YGR179C OKP1 Outer kinetochore protein required for accurate mitotic chromosome segregation forms a complex with Mcm21p and Okp1p that binds to centromeres via the CBF3 complex; uncharacterized protein 1396466 2896047 KLLA0_F15136g Kluyveromyces lactis uncharacterized protein XP_455759.1 1395315 D 28985 CDS KLLA0_F15158g 2896048 1397024..1399141 F 1 NC_006042.1 similar to uniprot|P53297 Saccharomyces cerevisiae YGR178C PBP1 Protein interacting with poly(A)-binding protein Pab1p likely involved in control of the extent of mRNA polyadenylation; uncharacterized protein 1399141 2896048 KLLA0_F15158g Kluyveromyces lactis uncharacterized protein XP_455760.1 1397024 D 28985 CDS KLLA0_F15180g 2896049 1399547..1401121 F 1 NC_006042.1 similar to uniprot|P40992 Saccharomyces cerevisiae YJL025W RRN7 involved in the transcription of 35S rRNA genes by RNA polymerase I member of yeast Pol I core factor (CF) also composed of Rrn11p Rrn6p and TATA-binding protein; uncharacterized protein 1401121 2896049 KLLA0_F15180g Kluyveromyces lactis uncharacterized protein XP_455761.1 1399547 D 28985 CDS KLLA0_F15202g 2896050 1401627..1403180 F 1 NC_006042.1 similar to uniprot|P53296 Saccharomyces cerevisiae YGR177C ATF2 Alcohol acetyltransferase may play a role in steroid detoxification forms volatile esters during fermentation which is important in brewing; alcohol O-acetyltransferase 1403180 2896050 KLLA0_F15202g Kluyveromyces lactis alcohol O-acetyltransferase XP_455762.1 1401627 D 28985 CDS KLLA0_F15224g 2896051 1403958..1405460 F 1 NC_006042.1 highly similar to uniprot|P32476 Saccharomyces cerevisiae YGR175C ERG1 Squalene epoxidase catalyzes the epoxidation of squalene to 2 3-oxidosqualene plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine; squalene monooxygenase 1405460 2896051 KLLA0_F15224g Kluyveromyces lactis squalene monooxygenase XP_455763.1 1403958 D 28985 CDS KLLA0_F15246g 2896052 1406040..1406471 F 1 NC_006042.1 similar to uniprot|P37267 Saccharomyces cerevisiae YGR174C CBP4 Essential for the expression and activity of ubiquinol-cytochrome c reductase ubiquinol--cytochrome-c reductase assembly factor; uncharacterized protein 1406471 2896052 KLLA0_F15246g Kluyveromyces lactis uncharacterized protein XP_455764.1 1406040 D 28985 CDS KLLA0_F15268g 2896053 complement(join(1406798..1407339,1407415..1407436)) F 1 NC_006042.1 similar to uniprot|P47064 Saccharomyces cerevisiae YJL024C APS3 Small subunit of the clathrin-associated adaptor complex AP-3 which is involved in vacuolar protein sorting related to the sigma subunit of the mammalian clathrin AP-3 complex suppressor of loss of casein kinase 1 function; uncharacterized protein 1407436 2896053 KLLA0_F15268g Kluyveromyces lactis uncharacterized protein XP_455765.1 1406798 R 28985 CDS KLLA0_F15312g 2896055 1408290..1408595 F 1 NC_006042.1 similar to uniprot|P53299 Saccharomyces cerevisiae YGR181W TIM13 Translocase of the inner membrane mitochondrial intermembrane space protein mediating import and insertion of polytopic inner membrane proteins Subunit of mitochondrial protein import machinery; protein translocase subunit TIM13 1408595 2896055 KLLA0_F15312g Kluyveromyces lactis protein translocase subunit TIM13 XP_455766.1 1408290 D 28985 CDS KLLA0_F15325g 2895994 complement(join(1409287..1409493,1409993..1410061)) F 1 NC_006042.1 similar to uniprot|P22289 Saccharomyces cerevisiae YGR183C QCR9 7.3 kDa subunit 9 of the ubiquinol cytochrome c oxidoreductase complex; ubiquinol--cytochrome-c reductase subunit 9 1410061 2895994 KLLA0_F15325g Kluyveromyces lactis ubiquinol--cytochrome-c reductase subunit 9 XP_455767.2 1409287 R 28985 CDS KLLA0_F15334g 2895834 complement(1410456..1416293) F 1 NC_006042.1 uniprot|O60014 Kluyveromyces lactis UBR1 N-END-RECOGNIZING PROTEIN (UBIQUITIN-PROTEIN LIGASE E3 COMPONENT) (N-RECOGNIN); E3 ubiquitin-protein ligase UBR1 1416293 2895834 KLLA0_F15334g Kluyveromyces lactis E3 ubiquitin-protein ligase UBR1 XP_455768.1 1410456 R 28985 CDS KLLA0_F15367g 2895996 1417215..1422344 F 1 NC_006042.1 similar to uniprot|Q07963 Saccharomyces cerevisiae YLR024C UBR2 Cytoplasmic ubiquitin-protein ligase (E3); uncharacterized protein 1422344 2895996 KLLA0_F15367g Kluyveromyces lactis uncharacterized protein XP_455770.1 1417215 D 28985 CDS KLLA0_F15389g 2895997 complement(1422689..1423882) F 1 NC_006042.1 highly similar to uniprot|P36421 Saccharomyces cerevisiae YGR185C TYS1 tyrosyl-tRNA synthetase cytoplasmic; tyrosine--tRNA ligase TYS1 1423882 2895997 KLLA0_F15389g Kluyveromyces lactis tyrosine--tRNA ligase TYS1 XP_455771.1 1422689 R 28985 CDS KLLA0_F15411g 2895998 1424591..1426651 F 1 NC_006042.1 similar to uniprot|P41895 Saccharomyces cerevisiae YGR186W TFG1 Largest subunit of the RNA Polymerase general transcription factor IIF (TFIIF) interacts with Fcp1p phosphatase and with TFIIB potentially phosphorylated by Cdc28p; transcription factor IIF subunit TFG1 1426651 2895998 KLLA0_F15411g Kluyveromyces lactis transcription factor IIF subunit TFG1 XP_455772.1 1424591 D 28985 CDS KLLA0_F15433g 2895999 complement(1426837..1427997) F 1 NC_006042.1 similar to uniprot|P48362 Saccharomyces cerevisiae YGR187C; uncharacterized protein 1427997 2895999 KLLA0_F15433g Kluyveromyces lactis uncharacterized protein XP_455773.1 1426837 R 28985 CDS KLLA0_F15455g 2896000 1428408..1428725 F 1 NC_006042.1 similar to uniprot|Q12431 Saccharomyces cerevisiae YLL014W Hypothetical ORF; uncharacterized protein 1428725 2896000 KLLA0_F15455g Kluyveromyces lactis uncharacterized protein XP_455774.1 1428408 D 28985 CDS KLLA0_F15477g 2896001 complement(1429123..1431915) F 1 NC_006042.1 some similarities with uniprot|Q02601 Saccharomyces cerevisiae YLL013C PUF3 member of the PUF protein family which is named for the founding members PUmilio and Fbf; mRNA-binding protein PUF3 1431915 2896001 KLLA0_F15477g Kluyveromyces lactis mRNA-binding protein PUF3 XP_455775.1 1429123 R 28985 CDS KLLA0_F15510g 2895864 1433494..1435362 F 1 NC_006042.1 some similarities with uniprot|Q07959 Saccharomyces cerevisiae YLR023C IZH3 Membrane protein involved in zinc metabolism member of the four-protein IZH family expression induced by zinc deficiency deletion reduces sensitivity to elevated zinc and shortens lag phase overexpression reduces Zap1p activity; uncharacterized protein 1435362 2895864 KLLA0_F15510g Kluyveromyces lactis uncharacterized protein XP_455777.1 1433494 D 28985 CDS KLLA0_F15532g 2895865 1436045..1436788 F 1 NC_006042.1 highly similar to uniprot|Q07953 Saccharomyces cerevisiae YLR022C SDO1 Protein required for cell viability; guanine nucleotide exchange factor SDO1 1436788 2895865 KLLA0_F15532g Kluyveromyces lactis guanine nucleotide exchange factor SDO1 XP_455778.1 1436045 D 28985 CDS KLLA0_F15554g 2895866 complement(1436864..1437343) F 1 NC_006042.1 similar to uniprot|Q07951 Saccharomyces cerevisiae YLR021W Hypothetical ORF; uncharacterized protein 1437343 2895866 KLLA0_F15554g Kluyveromyces lactis uncharacterized protein XP_455779.1 1436864 R 28985 CDS KLLA0_F15576g 2895867 1437595..1439133 F 1 NC_006042.1 similar to uniprot|Q07950 Saccharomyces cerevisiae YLR020C YEH2 Steryl ester hydrolase catalyzes steryl ester hydrolysis at the plasma membrane involved in sterol metabolism; uncharacterized protein 1439133 2895867 KLLA0_F15576g Kluyveromyces lactis uncharacterized protein XP_455780.1 1437595 D 28985 CDS KLLA0_F15598g 2895868 1439610..1441046 F 1 NC_006042.1 highly similar to uniprot|P33750 Saccharomyces cerevisiae YLL011W; rRNA-processing protein SOF1 1441046 2895868 KLLA0_F15598g Kluyveromyces lactis rRNA-processing protein SOF1 XP_455781.1 1439610 D 28985 CDS KLLA0_F15620g 2895869 complement(1441560..1442804) F 1 NC_006042.1 similar to uniprot|Q07800 Saccharomyces cerevisiae YLL010C; phosphatase 1442804 2895869 KLLA0_F15620g Kluyveromyces lactis phosphatase XP_455782.1 1441560 R 28985 CDS KLLA0_F15642g 2895870 1443555..1444742 F 1 NC_006042.1 weakly similar to uniprot|Q7LGY6 Saccharomyces cerevisiae YLR018C POM34 nuclear pore integral membrane protein; uncharacterized protein 1444742 2895870 KLLA0_F15642g Kluyveromyces lactis uncharacterized protein XP_455783.1 1443555 D 28985 CDS KLLA0_F15664g 2895871 complement(1444888..1445904) F 1 NC_006042.1 highly similar to uniprot|Q07938 Saccharomyces cerevisiae YLR017W MEU1 Methylthioadenosine phosphorylase (MTAP) catalyzes the initial step in the methionine salvage pathway affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity regulates ADH2 gene expression; S-methyl-5-thioadenosine phosphorylase 1445904 2895871 KLLA0_F15664g Kluyveromyces lactis S-methyl-5-thioadenosine phosphorylase XP_455784.1 1444888 R 28985 CDS KLLA0_F15686g 2895872 complement(join(1446371..1446532,1447294..1447323)) F 1 NC_006042.1 some similarities with uniprot|Q12287 Saccharomyces cerevisiae YLL009C COX17 Copper metallochaperone that shuttles copper from the cytosol to the mitochondrial intermembrane space for delivery to cytochrome c oxidase; copper metallochaperone COX17 1447323 2895872 KLLA0_F15686g Kluyveromyces lactis copper metallochaperone COX17 XP_455785.2 1446371 R 28985 CDS KLLA0_F15708g 2895873 1447749..1453451 F 1 NC_006042.1 similar to uniprot|P08678 Saccharomyces cerevisiae YJL005W CYR1 Adenylate cyclase required for cAMP production and cAMP-dependent protein kinase signaling involved in cell cycle control and glucose and nitrogen repression of sporulation; adenylate cyclase 1453451 2895873 KLLA0_F15708g Kluyveromyces lactis adenylate cyclase XP_455786.1 1447749 D 28985 CDS KLLA0_F15730g 2895874 complement(1453582..1454175) F 1 NC_006042.1 similar to uniprot|P41544 Saccharomyces cerevisiae YJL004C SYS1 Multicopy suppressor of ypt6 null mutation; uncharacterized protein 1454175 2895874 KLLA0_F15730g Kluyveromyces lactis uncharacterized protein XP_455787.1 1453582 R 28985 CDS KLLA0_F15752g 2895875 1454735..1456981 F 1 NC_006042.1 similar to uniprot|P32892 Saccharomyces cerevisiae YLL008W DRS1 Nucleolar DEAD-box protein required for ribosome assembly and function; uncharacterized protein 1456981 2895875 KLLA0_F15752g Kluyveromyces lactis uncharacterized protein XP_455788.1 1454735 D 28985 CDS KLLA0_F15774g 2895876 complement(1457087..1459060) F 1 NC_006042.1 weakly similar to uniprot|Q07799 Saccharomyces cerevisiae YLL007C Hypothetical ORF; uncharacterized protein 1459060 2895876 KLLA0_F15774g Kluyveromyces lactis uncharacterized protein XP_455789.1 1457087 R 28985 CDS KLLA0_F15796g 2895845 1459596..1460900 F 1 NC_006042.1 similar to uniprot|P41800 Saccharomyces cerevisiae YLL006W MMM1 Mitochondrial outer membrane protein required for normal mitochondrial morphology and mtDNA stability involved in tethering mitochondria to the actin cytoskeleton and in anchoring mtDNA nucleoids; ERMES complex subunit MMM1 1460900 2895845 KLLA0_F15796g Kluyveromyces lactis ERMES complex subunit MMM1 XP_455790.1 1459596 D 28985 CDS KLLA0_F15807g 2895843 complement(1460897..1463680) F 1 NC_006042.1 weakly similar to uniprot|Q07798 Saccharomyces cerevisiae YLL005C SPO75 Meiosis-specific protein of unknown function required for spore wall formation during sporulation dispensable for both nuclear divisions during meiosis; uncharacterized protein 1463680 2895843 KLLA0_F15807g Kluyveromyces lactis uncharacterized protein XP_455791.1 1460897 R 28985 CDS KLLA0_F15829g 2895844 complement(1464112..1466337) F 1 NC_006042.1 similar to uniprot|P31382 Saccharomyces cerevisiae YAL023C PMT2 Transfers mannosyl residues from dolichyl phosphate-D-mannose to seryl and threonyl residues in proteins acts in complex with Pmt1p dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase; dolichyl-phosphate-mannose-protein mannosyltransferase PMT2 1466337 2895844 KLLA0_F15829g Kluyveromyces lactis dolichyl-phosphate-mannose-protein mannosyltransferase PMT2 XP_455792.1 1464112 R 28985 CDS KLLA0_F15862g 2895846 complement(1466697..1467986) F 1 NC_006042.1 similar to uniprot|P31381 Saccharomyces cerevisiae YAL022C FUN26 Nucleoside transporter with broad nucleoside selectivity localized to intracellular membranes; nucleoside transmembrane transporter FUN26 1467986 2895846 KLLA0_F15862g Kluyveromyces lactis nucleoside transmembrane transporter FUN26 XP_455794.1 1466697 R 28985 CDS KLLA0_F15884g 2895850 complement(1468612..1470984) F 1 NC_006042.1 similar to uniprot|P31384 Saccharomyces cerevisiae YAL021C CCR4 Component of the CCR4-NOT transcriptional complex which is involved in regulation of gene expression component of the major cytoplasmic deadenylase which is involved in mRNA poly(A) tail shortening; CCR4-NOT core exoribonuclease subunit CCR4 1470984 2895850 KLLA0_F15884g Kluyveromyces lactis CCR4-NOT core exoribonuclease subunit CCR4 XP_455795.1 1468612 R 28985 CDS KLLA0_F15906g 2895848 complement(1472413..1473462) F 1 NC_006042.1 similar to uniprot|P31386 Saccharomyces cerevisiae YAL020C ATS1 Protein with a potential role in regulatory interactions between microtubules and the cell cycle as suggested by genetic and physical interactions with Nap1p and genetic interactions with TUB1; uncharacterized protein 1473462 2895848 KLLA0_F15906g Kluyveromyces lactis uncharacterized protein XP_455796.1 1472413 R 28985 CDS KLLA0_F15928g 2895849 1475341..1476714 F 1 NC_006042.1 similar to uniprot|P35198 Saccharomyces cerevisiae YDR277C MTH1 Negative regulator of the glucose-sensing signal transduction pathway required for repression of transcription by Rgt1p interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors phosphorylated by Yck1p triggering Mth1p degradation; uncharacterized protein 1476714 2895849 KLLA0_F15928g Kluyveromyces lactis uncharacterized protein XP_455797.1 1475341 D 28985 CDS KLLA0_F15950g 2895852 1477113..1478522 F 1 NC_006042.1 similar to uniprot|P20449 Saccharomyces cerevisiae YOR046C DBP5 Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus; ATP-dependent RNA helicase DBP5 1478522 2895852 KLLA0_F15950g Kluyveromyces lactis ATP-dependent RNA helicase DBP5 XP_455798.1 1477113 D 28985 CDS KLLA0_F15961g 9487445 complement(1479993..1480163) F 1 NC_006042.1 similar to uniprot|P33448 Saccharomyces cerevisiae YOR045W TOM6 involved in supporting the cooperativity between receptors and the general insertion pore and facilitating the release of preproteins from import components; uncharacterized protein 1480163 9487445 KLLA0_F15961g Kluyveromyces lactis uncharacterized protein XP_002999433.1 1479993 R 28985 CDS KLLA0_F15972g 2895851 complement(1481761..1483137) F 1 NC_006042.1 similar to uniprot|P12611 Saccharomyces cerevisiae YOR043W WHI2 Protein required with binding partner Psr1p for full activation of the general stress response possibly through Msn2p dephosphorylation regulates growth during the diauxic shift negative regulator of G1 cyclin expression; uncharacterized protein 1483137 2895851 KLLA0_F15972g Kluyveromyces lactis uncharacterized protein XP_455799.1 1481761 R 28985 CDS KLLA0_F15994g 2895854 complement(1484383..1485666) F 1 NC_006042.1 similar to uniprot|Q08412 Saccharomyces cerevisiae YOR042W CUE5 Protein containing a CUE domain that binds ubiquitin which may facilitate intramolecular monoubiquitination green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; ubiquitin-binding protein CUE5 1485666 2895854 KLLA0_F15994g Kluyveromyces lactis ubiquitin-binding protein CUE5 XP_455800.1 1484383 R 28985 CDS KLLA0_F16016g 2895855 complement(1486406..1487257) F 1 NC_006042.1 similar to uniprot|Q12320 Saccharomyces cerevisiae YOR040W GLO4 Mitochondrial glyoxalase II catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; hydroxyacylglutathione hydrolase GLO4 1487257 2895855 KLLA0_F16016g Kluyveromyces lactis hydroxyacylglutathione hydrolase GLO4 XP_455801.1 1486406 R 28985 CDS KLLA0_F16038g 2895853 complement(1487475..1490063) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 1490063 2895853 KLLA0_F16038g Kluyveromyces lactis uncharacterized protein XP_455802.1 1487475 R 28985 CDS KLLA0_F16060g 2895673 1490815..1491960 F 1 NC_006042.1 similar to uniprot|P36052 Saccharomyces cerevisiae YKL162C Hypothetical ORF; type II protein arginine methyltransferase 1491960 2895673 KLLA0_F16060g Kluyveromyces lactis type II protein arginine methyltransferase XP_455803.1 1490815 D 28985 CDS KLLA0_F16082g 2895674 complement(1492435..1493547) F 1 NC_006042.1 similar to uniprot|Q08417 Saccharomyces cerevisiae YOR049C RSB1 Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane; phospholipid-translocating ATPase RSB1 1493547 2895674 KLLA0_F16082g Kluyveromyces lactis phospholipid-translocating ATPase RSB1 XP_455804.1 1492435 R 28985 CDS KLLA0_F16104g 2895675 1495067..1497241 F 1 NC_006042.1 similar to uniprot|P36148 Saccharomyces cerevisiae YKR067W GPT2 Glycerol-3-phosphate acyltransferase located in both lipid particles and the ER involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone which are intermediate steps in lipid biosynthesis; bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase GPT2 1497241 2895675 KLLA0_F16104g Kluyveromyces lactis bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase GPT2 XP_455805.1 1495067 D 28985 CDS KLLA0_F16126g 2895676 complement(1497393..1498019) F 1 NC_006042.1 highly similar to uniprot|P36149 Saccharomyces cerevisiae YKR068C BET3 Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles component of the TRAPP (transport protein particle) complex; TRAPP complex core subunit BET3 1498019 2895676 KLLA0_F16126g Kluyveromyces lactis TRAPP complex core subunit BET3 XP_455806.1 1497393 R 28985 CDS KLLA0_F16148g 2895677 complement(1498362..1499645) F 1 NC_006042.1 similar to uniprot|Q6Q5I2 Saccharomyces cerevisiae YOR051C which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; uncharacterized protein 1499645 2895677 KLLA0_F16148g Kluyveromyces lactis uncharacterized protein XP_455807.1 1498362 R 28985 CDS KLLA0_F16170g 2895678 1500288..1502078 F 1 NC_006042.1 similar to uniprot|P36150 Saccharomyces cerevisiae YKR069W MET1 S-adenosyl-L-methionine uroporphyrinogen III transmethylase; uroporphyrinogen-III C-methyltransferase 1502078 2895678 KLLA0_F16170g Kluyveromyces lactis uroporphyrinogen-III C-methyltransferase XP_455808.2 1500288 D 28985 CDS KLLA0_F16192g 2895679 1502331..1503398 F 1 NC_006042.1 similar to uniprot|P36151 Saccharomyces cerevisiae YKR070W Hypothetical ORF; uncharacterized protein 1503398 2895679 KLLA0_F16192g Kluyveromyces lactis uncharacterized protein XP_455809.1 1502331 D 28985 CDS KLLA0_F16214g 2895680 complement(1503855..1504211) F 1 NC_006042.1 some similarities with uniprot|O00017 Saccharomyces cerevisiae YOR052C; uncharacterized protein 1504211 2895680 KLLA0_F16214g Kluyveromyces lactis uncharacterized protein XP_455810.1 1503855 R 28985 CDS KLLA0_F16236g 2895681 complement(1504621..1505652) F 1 NC_006042.1 similar to uniprot|P36152 Saccharomyces cerevisiae YKR071C DRE2; electron carrier DRE2 1505652 2895681 KLLA0_F16236g Kluyveromyces lactis electron carrier DRE2 XP_455811.1 1504621 R 28985 CDS KLLA0_F16258g 2895658 complement(1506192..1508141) F 1 NC_006042.1 weakly similar to uniprot|O00019 Saccharomyces cerevisiae YOR054C VHS3 Regulatory subunit of Ppz1p which is an isoform of serine/threonine protein phosphatase Z involved in regulation of potassium transport overexpression suppresses the synthetic lethality of the hal3 sit4 double mutation; phosphopantothenoylcysteine decarboxylase complex subunit VHS3 1508141 2895658 KLLA0_F16258g Kluyveromyces lactis phosphopantothenoylcysteine decarboxylase complex subunit VHS3 XP_455812.1 1506192 R 28985 CDS KLLA0_F16280g 2895659 complement(1508963..1510381) F 1 NC_006042.1 similar to uniprot|O00021 Saccharomyces cerevisiae YOR056C NOB1 Nin1 (One) Binding protein essential nuclear protein involved in proteasome maturation and synthesis of 40S ribosome subunits required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA.; rRNA-binding endoribonuclease 1510381 2895659 KLLA0_F16280g Kluyveromyces lactis rRNA-binding endoribonuclease XP_455813.1 1508963 R 28985 CDS KLLA0_F16302g 2895660 1510954..1512093 F 1 NC_006042.1 similar to uniprot|Q08446 Saccharomyces cerevisiae YOR057W SGT1 Probable cochaperone regulates activity of Cyr1p (adenylyl cyclase) involved in assembly of the kinetochore complex associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; co-chaperone SGT1 1512093 2895660 KLLA0_F16302g Kluyveromyces lactis co-chaperone SGT1 XP_455814.1 1510954 D 28985 CDS KLLA0_F16324g 2895661 complement(1512218..1514623) F 1 NC_006042.1 weakly similar to uniprot|P50275 Saccharomyces cerevisiae YOR058C ASE1 Member of a family of microtubule-associated proteins (MAPs) that function at the mitotic spindle midzone required for spindle elongation undergoes cell cycle-regulated degradation by anaphase promoting complex potential Cdc28p substrate; uncharacterized protein 1514623 2895661 KLLA0_F16324g Kluyveromyces lactis uncharacterized protein XP_455815.1 1512218 R 28985 CDS KLLA0_F16401g 2895664 1516101..1516544 F 1 NC_006042.1 highly similar to uniprot|P36154 Saccharomyces cerevisiae YKR074W Hypothetical ORF; uncharacterized protein 1516544 2895664 KLLA0_F16401g Kluyveromyces lactis uncharacterized protein XP_455817.1 1516101 D 28985 CDS KLLA0_F16423g 2895665 complement(1516717..1518096) F 1 NC_006042.1 similar to uniprot|O00022 Saccharomyces cerevisiae YOR059C Hypothetical ORF; uncharacterized protein 1518096 2895665 KLLA0_F16423g Kluyveromyces lactis uncharacterized protein XP_455818.1 1516717 R 28985 CDS KLLA0_F16445g 2895666 complement(1518557..1519339) F 1 NC_006042.1 similar to uniprot|O00023 Saccharomyces cerevisiae YOR060C Protein required for cell viability; uncharacterized protein 1519339 2895666 KLLA0_F16445g Kluyveromyces lactis uncharacterized protein XP_455819.1 1518557 R 28985 CDS KLLA0_F16467g 2895667 1519800..1520822 F 1 NC_006042.1 highly similar to uniprot|P19454 Saccharomyces cerevisiae YOR061W CKA2 alpha' subunit of casein kinase II; casein kinase 2 catalytic subunit CKA2 1520822 2895667 KLLA0_F16467g Kluyveromyces lactis casein kinase 2 catalytic subunit CKA2 XP_455820.1 1519800 D 28985 CDS KLLA0_F16489g 2895668 complement(1521430..1522218) F 1 NC_006042.1 some similarities with uniprot|P36155 Saccharomyces cerevisiae or YOR062c uniprot|P36025 Saccharomyces cerevisiae; uncharacterized protein 1522218 2895668 KLLA0_F16489g Kluyveromyces lactis uncharacterized protein XP_455821.1 1521430 R 28985 CDS KLLA0_F16511g 2895669 1523895..1525058 F 1 NC_006042.1 highly similar to uniprot|P14126 Saccharomyces cerevisiae YOR063W; 60S ribosomal protein uL3 1525058 2895669 KLLA0_F16511g Kluyveromyces lactis 60S ribosomal protein uL3 XP_455822.1 1523895 D 28985 CDS KLLA0_F16533g 2895670 complement(1525315..1525986) F 1 NC_006042.1 weakly similar to uniprot|O00025 Saccharomyces cerevisiae YOR064C YNG1 Yeast homolog of mammalian Ing1 histone acetyltransferase complex component; uncharacterized protein 1525986 2895670 KLLA0_F16533g Kluyveromyces lactis uncharacterized protein XP_455823.1 1525315 R 28985 CDS KLLA0_F16555g 2895671 1526892..1527770 F 1 NC_006042.1 uniprot|Q00988 Kluyveromyces lactis KLLA0F16555g CYT1 Cytochrome c1, heme protein, mitochondrial precursor; ubiquinol--cytochrome-c reductase catalytic subunit CYT1 1527770 2895671 KLLA0_F16555g Kluyveromyces lactis ubiquinol--cytochrome-c reductase catalytic subunit CYT1 XP_455824.1 1526892 D 28985 CDS KLLA0_F16577g 2895643 complement(1529359..1529706) F 1 NC_006042.1 no similarity; uncharacterized protein 1529706 2895643 KLLA0_F16577g Kluyveromyces lactis uncharacterized protein XP_455825.1 1529359 R 28985 CDS KLLA0_F16599g 2895644 1529975..1531561 F 1 NC_006042.1 weakly similar to uniprot|O00026 Saccharomyces cerevisiae YOR066W Protein of unknown function potential Cdc28p substrate; uncharacterized protein 1531561 2895644 KLLA0_F16599g Kluyveromyces lactis uncharacterized protein XP_455826.1 1529975 D 28985 CDS KLLA0_F16621g 2895645 complement(1531745..1533430) F 1 NC_006042.1 highly similar to uniprot|P40351 Saccharomyces cerevisiae YOR067C ALG8 adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein glycosyl transferase; dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase 1533430 2895645 KLLA0_F16621g Kluyveromyces lactis dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase XP_455827.1 1531745 R 28985 CDS KLLA0_F16643g 2895646 1533628..1535625 F 1 NC_006042.1 similar to uniprot|Q92331 Saccharomyces cerevisiae YOR069W VPS5 Component of the retromer coat that retrieves proteins from late endosomes sorting nexin I homolog; sorting nexin 1 1535625 2895646 KLLA0_F16643g Kluyveromyces lactis sorting nexin 1 XP_455828.1 1533628 D 28985 CDS KLLA0_F16665g 2895647 complement(1535656..1538124) F 1 NC_006042.1 similar to uniprot|P36159 Saccharomyces cerevisiae YKR079C TRZ1 Protein required for cell viability; tRNase Z 1538124 2895647 KLLA0_F16665g Kluyveromyces lactis tRNase Z XP_455829.1 1535656 R 28985 CDS KLLA0_F16709g 2895649 1539612..1541207 F 1 NC_006042.1 some similarities with uniprot|O00022 Saccharomyces cerevisiae YOR059C Hypothetical ORF; uncharacterized protein 1541207 2895649 KLLA0_F16709g Kluyveromyces lactis uncharacterized protein XP_455830.1 1539612 D 28985 CDS KLLA0_F16731g 2895650 complement(1541253..1541663) F 1 NC_006042.1 weakly similar to uniprot|P32613 Saccharomyces cerevisiae YEL048C Hypothetical ORF; uncharacterized protein 1541663 2895650 KLLA0_F16731g Kluyveromyces lactis uncharacterized protein XP_455831.1 1541253 R 28985 CDS KLLA0_F16753g 2895651 complement(1541959..1543422) F 1 NC_006042.1 similar to uniprot|P21375 Saccharomyces cerevisiae YJR051W OSM1 Fumarate reductase catalyzes the reduction of fumarate to succinate required for the reoxidation of intracellular NADH under anaerobic conditions mutations cause osmotic sensitivity; fumarate reductase 1543422 2895651 KLLA0_F16753g Kluyveromyces lactis fumarate reductase XP_455832.1 1541959 R 28985 CDS KLLA0_F16775g 2895652 complement(1544839..1546026) F 1 NC_006042.1 highly similar to uniprot|P37303 Saccharomyces cerevisiae YEL046C GLY1 Threonine aldolase catalyzes the cleavage of L-allo-threonine and L-threonine to glycine involved in glycine biosynthesis; threonine aldolase GLY1 1546026 2895652 KLLA0_F16775g Kluyveromyces lactis threonine aldolase GLY1 XP_455833.1 1544839 R 28985 CDS KLLA0_F16797g 2895653 1547190..1547609 F 1 NC_006042.1 similar to uniprot|P32617 Saccharomyces cerevisiae YEL044W IES6 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; uncharacterized protein 1547609 2895653 KLLA0_F16797g Kluyveromyces lactis uncharacterized protein XP_455834.1 1547190 D 28985 CDS KLLA0_F16819g 2895654 1548402..1550327 F 1 NC_006042.1 uniprot|Q96WJ2 Kluyveromyces lactis PRM1 Paromomycin- resistance protein Prm1; uncharacterized protein 1550327 2895654 KLLA0_F16819g Kluyveromyces lactis uncharacterized protein XP_455835.1 1548402 D 28985 CDS KLLA0_F16841g 2895655 complement(1550523..1551236) F 1 NC_006042.1 similar to uniprot|P21374 Saccharomyces cerevisiae YJR050W ISY1 Component of the spliceosome complex involved in pre-mRNA splicing auxiliary splicing factor that may modulate Syf1p activity and help optimize splicing isy1 syf2 double mutation activates the spindle checkpoint causing cell cycle arrest; uncharacterized protein 1551236 2895655 KLLA0_F16841g Kluyveromyces lactis uncharacterized protein XP_455836.1 1550523 R 28985 CDS KLLA0_F16863g 2895656 1551578..1553146 F 1 NC_006042.1 uniprot|Q9HEM6 Kluyveromyces lactis KLLA0F16863g GDA1 Guanosine-diphosphatase; guanosine diphosphatase 1553146 2895656 KLLA0_F16863g Kluyveromyces lactis guanosine diphosphatase XP_455837.1 1551578 D 28985 CDS KLLA0_F16885g 2895657 1553518..1555107 F 1 NC_006042.1 highly similar to uniprot|P21373 Saccharomyces cerevisiae YJR049C UTR1 NAD kinase active as a hexamer enhances the activity of ferric reductase (Fre1p); NADH/NAD(+) kinase 1555107 2895657 KLLA0_F16885g Kluyveromyces lactis NADH/NAD(+) kinase XP_455838.1 1553518 D 28985 CDS KLLA0_F16907g 2895634 1555857..1557215 F 1 NC_006042.1 similar to uniprot|P32623 Saccharomyces cerevisiae YEL040W UTR2 Putative glycosidase glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck has a role in cell wall maintenance; chitin transglycosylase UTR2 1557215 2895634 KLLA0_F16907g Kluyveromyces lactis chitin transglycosylase UTR2 XP_455839.1 1555857 D 28985 CDS KLLA0_F16929g 2894947 complement(1558278..1558610) F 1 NC_006042.1 uniprot|P32556 Kluyveromyces lactis KLLA0F16929g CYCK Cytochrome c; cytochrome c isoform 2 1558610 2894947 KLLA0_F16929g Kluyveromyces lactis cytochrome c isoform 2 XP_455841.1 1558278 R 28985 CDS KLLA0_F16962g 2895635 complement(1559454..1561190) F 1 NC_006042.1 uniprot|O74722 Kluyveromyces lactis PDC Pyruvate decarboxylase; uncharacterized protein 1561190 2895635 KLLA0_F16962g Kluyveromyces lactis uncharacterized protein XP_455842.1 1559454 R 28985 CDS KLLA0_F17006g 2895637 complement(1561859..1563106) F 1 NC_006042.1 uniprot|O60042 Kluyveromyces lactis GSK-3 Protein kinase; serine/threonine protein kinase RIM11 1563106 2895637 KLLA0_F17006g Kluyveromyces lactis serine/threonine protein kinase RIM11 XP_455844.1 1561859 R 28985 CDS KLLA0_F17028g 2895638 complement(1563907..1564425) F 1 NC_006042.1 no similarity; uncharacterized protein 1564425 2895638 KLLA0_F17028g Kluyveromyces lactis uncharacterized protein XP_455845.1 1563907 R 28985 CDS KLLA0_F17050g 2895639 complement(1564921..1565937) F 1 NC_006042.1 similar to uniprot|P32419 Saccharomyces cerevisiae YDL078C MDH3 Cytoplasmic malate dehydrogenase catalyzes interconversion of malate and oxaloacetate involved in the glyoxylate cycle; malate dehydrogenase MDH3 1565937 2895639 KLLA0_F17050g Kluyveromyces lactis malate dehydrogenase MDH3 XP_455846.1 1564921 R 28985 CDS KLLA0_F17072g 2895640 complement(1566668..1567240) F 1 NC_006042.1 similar to uniprot|P39110 Saccharomyces cerevisiae YMR138W CIN4 GTP-binding protein involved in beta-tubulin (Tub2p) folding; Arf family GTPase CIN4 1567240 2895640 KLLA0_F17072g Kluyveromyces lactis Arf family GTPase CIN4 XP_455847.1 1566668 R 28985 CDS KLLA0_F17094g 2895641 1567507..1569048 F 1 NC_006042.1 similar to uniprot|Q759M6 Ashbya gossypii ADR250C ADR250Cp and weakly similar to YMR137C uniprot|P30620 Saccharomyces cerevisiae YMR137C PSO2 Required for a post-incision step in the repair of DNA single and double-strand breaks that result from interstrand crosslinks produced by a variety of mono- and bi-functional psoralen derivatives induced by UV-irradiation; DNA cross-link repair protein PSO2 1569048 2895641 KLLA0_F17094g Kluyveromyces lactis DNA cross-link repair protein PSO2 XP_455848.1 1567507 D 28985 CDS KLLA0_F17116g 2895642 complement(1569192..1570367) F 1 NC_006042.1 weakly similar to uniprot|P40209 Saccharomyces cerevisiae YMR136W GAT2; uncharacterized protein 1570367 2895642 KLLA0_F17116g Kluyveromyces lactis uncharacterized protein XP_455849.1 1569192 R 28985 CDS KLLA0_F17138g 2895620 1571290..1572351 F 1 NC_006042.1 similar to uniprot|Q759M8 Ashbya gossypii ADR248C ADR248Cp and weakly similar to YMR135C uniprot|P40208 Saccharomyces cerevisiae YMR135C GID8 Protein of unknown function involved in proteasome-dependent catabolite inactivation of fructose-1 6-bisphosphatase contains LisH and CTLH domains like Vid30p; glucose-induced degradation complex subunit GID8 1572351 2895620 KLLA0_F17138g Kluyveromyces lactis glucose-induced degradation complex subunit GID8 XP_455850.1 1571290 D 28985 CDS KLLA0_F17160g 2895621 complement(1572441..1573163) F 1 NC_006042.1 similar to uniprot|P40207 Saccharomyces cerevisiae YMR134W Protein required for cell viability; uncharacterized protein 1573163 2895621 KLLA0_F17160g Kluyveromyces lactis uncharacterized protein XP_455851.1 1572441 R 28985 CDS KLLA0_F17182g 2895622 1574167..1574808 F 1 NC_006042.1 some similarities with uniprot|Q07988 Saccharomyces cerevisiae YLR040C Hypothetical ORF; uncharacterized protein 1574808 2895622 KLLA0_F17182g Kluyveromyces lactis uncharacterized protein XP_455852.1 1574167 D 28985 CDS KLLA0_F17198g 9487399 complement(join(1574538..1574726,1574995..1575825)) F 1 NC_006042.1 weakly similar to uniprot|P32841 Saccharomyces cerevisiae YMR133W REC114 Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division; uncharacterized protein 1575825 9487399 KLLA0_F17198g Kluyveromyces lactis uncharacterized protein XP_002999434.1 1574538 R 28985 CDS KLLA0_F17215g 2895624 1576281..1576910 F 1 NC_006042.1 similar to uniprot|P40206 Saccharomyces cerevisiae YMR132C JLP2 Hypothetical ORF; uncharacterized protein 1576910 2895624 KLLA0_F17215g Kluyveromyces lactis uncharacterized protein XP_455854.1 1576281 D 28985 CDS KLLA0_F17237g 2895625 1577197..1578768 F 1 NC_006042.1 highly similar to uniprot|Q04225 Saccharomyces cerevisiae YMR131C RRB1 essential nuclear protein involved in early steps of ribosome biogenesis; ribosome biosynthesis protein RRB1 1578768 2895625 KLLA0_F17237g Kluyveromyces lactis ribosome biosynthesis protein RRB1 XP_455855.1 1577197 D 28985 CDS KLLA0_F17259g 2895626 1579097..1582111 F 1 NC_006042.1 similar to uniprot|P40395 Saccharomyces cerevisiae YLR039C RIC1 Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p involved in transcription of ribosomal protein genes and ribosomal RNA; uncharacterized protein 1582111 2895626 KLLA0_F17259g Kluyveromyces lactis uncharacterized protein XP_455856.1 1579097 D 28985 CDS KLLA0_F17281g 2895627 1582850..1583098 F 1 NC_006042.1 highly similar to uniprot|Q01519 Saccharomyces cerevisiae YLR038C COX12 Subunit VIb of cytochrome c oxidase which is the terminal member of the mitochondrial inner membrane electron transport chain required for assembly of fully active cytochrome c oxidase but not required for activity after assembly; cytochrome c oxidase subunit VIb 1583098 2895627 KLLA0_F17281g Kluyveromyces lactis cytochrome c oxidase subunit VIb XP_455857.1 1582850 D 28985 CDS KLLA0_F17325g 2895629 complement(1584146..1585069) F 1 NC_006042.1 similar to uniprot|Q04223 Saccharomyces cerevisiae YMR130W Hypothetical ORF; uncharacterized protein 1585069 2895629 KLLA0_F17325g Kluyveromyces lactis uncharacterized protein XP_455858.1 1584146 R 28985 CDS KLLA0_F17347g 2895630 1585317..1587149 F 1 NC_006042.1 some similarities with uniprot|Q07980 Saccharomyces cerevisiae YLR035C MLH2 Protein required for DNA mismatch repair in mitosis and meiosis; mismatch repair protein MLH2 1587149 2895630 KLLA0_F17347g Kluyveromyces lactis mismatch repair protein MLH2 XP_455859.1 1585317 D 28985 CDS KLLA0_F17369g 2895631 complement(1587214..1591122) F 1 NC_006042.1 similar to uniprot|P39685 Saccharomyces cerevisiae YMR129W POM152 Nuclear pore membrane glycoprotein may be involved in duplication of nuclear pores and nuclear pore complexes during S-phase; uncharacterized protein 1591122 2895631 KLLA0_F17369g Kluyveromyces lactis uncharacterized protein XP_455860.1 1587214 R 28985 CDS KLLA0_F17391g 2895632 1592278..1593708 F 1 NC_006042.1 highly similar to uniprot|Q12078 Saccharomyces cerevisiae YLR034C SMF3 Putative metal transporter Nramp homolog homolog of SMF1 and SMF2; uncharacterized protein 1593708 2895632 KLLA0_F17391g Kluyveromyces lactis uncharacterized protein XP_455861.1 1592278 D 28985 CDS KLLA0_F17413g 2895633 complement(join(1594037..1595489,1595709..1595764)) F 1 NC_006042.1 similar to uniprot|Q07979 Saccharomyces cerevisiae YLR033W RSC58 Remodels the structure of chromatin complex 58KDa subunit; Chromatin Remodeling Complex subunit; uncharacterized protein 1595764 2895633 KLLA0_F17413g Kluyveromyces lactis uncharacterized protein XP_455862.2 1594037 R 28985 CDS KLLA0_F17435g 2895605 complement(1596081..1599896) F 1 NC_006042.1 similar to uniprot|Q04217 Saccharomyces cerevisiae YMR128W ECM16 Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP predominantly nucleolar in distribution required for 18S rRNA synthesis; ATP-dependent RNA helicase ECM16 1599896 2895605 KLLA0_F17435g Kluyveromyces lactis ATP-dependent RNA helicase ECM16 XP_455863.1 1596081 R 28985 CDS KLLA0_F17457g 2895606 1600261..1601220 F 1 NC_006042.1 similar to uniprot|P40963 Saccharomyces cerevisiae YMR127C SAS2 Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p) which acetylates free histones and nucleosomes and regulates transcriptional silencing member of the MYSTacetyltransferase family; histone acetyltransferase 1601220 2895606 KLLA0_F17457g Kluyveromyces lactis histone acetyltransferase XP_455864.1 1600261 D 28985 CDS KLLA0_F17479g 2895607 complement(1601287..1604631) F 1 NC_006042.1 similar to uniprot|P32849 Saccharomyces cerevisiae YLR032W RAD5 Single-stranded DNA-dependent ATPase involved in postreplication repair; DNA helicase RAD5 1604631 2895607 KLLA0_F17479g Kluyveromyces lactis DNA helicase RAD5 XP_455865.1 1601287 R 28985 CDS KLLA0_F17501g 2895608 1605244..1606224 F 1 NC_006042.1 similar to uniprot|Q04216 Saccharomyces cerevisiae YMR126C DLT1 Protein of unknown function deletion causes sensitivity to thermal stress; uncharacterized protein 1606224 2895608 KLLA0_F17501g Kluyveromyces lactis uncharacterized protein XP_455866.1 1605244 D 28985 CDS KLLA0_F17523g 2895609 complement(1606456..1609023) F 1 NC_006042.1 similar to uniprot|P34160 Saccharomyces cerevisiae YMR125W STO1 Large subunit of the nuclear mRNA cap-binding protein complex interacts with Npl3p to carry poly(A) mRNA from the nucleus to the cytoplasm also involved in mRNA degradation in the nucleus orthologous to mammalian CBP80; uncharacterized protein 1609023 2895609 KLLA0_F17523g Kluyveromyces lactis uncharacterized protein XP_455867.2 1606456 R 28985 CDS KLLA0_F17545g 2895610 complement(1609839..1612619) F 1 NC_006042.1 weakly similar to uniprot|P39523 Saccharomyces cerevisiae YMR124W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm bud and bud neck; uncharacterized protein 1612619 2895610 KLLA0_F17545g Kluyveromyces lactis uncharacterized protein XP_455868.1 1609839 R 28985 CDS KLLA0_F17567g 2895611 complement(1613341..1613721) F 1 NC_006042.1 similar to uniprot|Q03880 Saccharomyces cerevisiae YMR123W PKR1 Protein of unknown function overproduction confers resistance to Pichia farinosa killer toxin; uncharacterized protein 1613721 2895611 KLLA0_F17567g Kluyveromyces lactis uncharacterized protein XP_455869.1 1613341 R 28985 CDS KLLA0_F17589g 2895612 complement(1614223..1614759) F 1 NC_006042.1 some similarities with uniprot|Q3E842 Saccharomyces cerevisiae YMR122W-A; uncharacterized protein 1614759 2895612 KLLA0_F17589g Kluyveromyces lactis uncharacterized protein XP_455870.1 1614223 R 28985 CDS KLLA0_F17611g 2895613 complement(1616198..1616629) F 1 NC_006042.1 no similarity; uncharacterized protein 1616629 2895613 KLLA0_F17611g Kluyveromyces lactis uncharacterized protein XP_455871.1 1616198 R 28985 CDS KLLA0_F17633g 2895614 1618128..1618742 F 1 NC_006042.1 highly similar to uniprot|P54780 Saccharomyces cerevisiae RPL15B and to uniprot|P05748 Saccharomyces cerevisiae YLR029C RPL15A; 60S ribosomal protein eL15 1618742 2895614 KLLA0_F17633g Kluyveromyces lactis 60S ribosomal protein eL15 XP_455872.1 1618128 D 28985 CDS KLLA0_F17655g 2895615 1619715..1621487 F 1 NC_006042.1 highly similar to uniprot|P38009 Saccharomyces cerevisiae YMR120C ADE17 Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities isozyme of Ade16p ade16 ade17 mutants require adenine and histidine; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE17 1621487 2895615 KLLA0_F17655g Kluyveromyces lactis bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE17 XP_455873.1 1619715 D 28985 CDS KLLA0_F17677g 2895616 complement(1622629..1624656) F 1 NC_006042.1 similar to uniprot|P54074 Saccharomyces cerevisiae YMR119W ASI1 Putative integral membrane E3 ubiquitin ligase genetic interactions suggest a role in negative regulation of amino acid uptake; uncharacterized protein 1624656 2895616 KLLA0_F17677g Kluyveromyces lactis uncharacterized protein XP_455874.1 1622629 R 28985 CDS KLLA0_F17754g 2895619 1625775..1627040 F 1 NC_006042.1 highly similar to uniprot|P23542 Saccharomyces cerevisiae YLR027C AAT2 Cytosolic aspartate aminotransferase involved in nitrogen metabolism localizes to peroxisomes in oleate-grown cells; aspartate transaminase AAT2 1627040 2895619 KLLA0_F17754g Kluyveromyces lactis aspartate transaminase AAT2 XP_455876.1 1625775 D 28985 CDS KLLA0_F17776g 2895596 complement(1627198..1628859) F 1 NC_006042.1 weakly similar to uniprot|Q04301 Saccharomyces cerevisiae YMR088C VBA1 Permease of basic amino acids in the vacuolar membrane; uncharacterized protein 1628859 2895596 KLLA0_F17776g Kluyveromyces lactis uncharacterized protein XP_455877.1 1627198 R 28985 CDS KLLA0_F17798g 2895597 1629735..1630688 F 1 NC_006042.1 similar to uniprot|Q01590 Saccharomyces cerevisiae YLR026C SED5 Sed5p is a t-SNARE (soluble NSF attachment protein receptor) required in ER to Golgi transport; t-SNARE syntaxin 1630688 2895597 KLLA0_F17798g Kluyveromyces lactis t-SNARE syntaxin XP_455878.1 1629735 D 28985 CDS KLLA0_F17820g 2895598 complement(1630888..1631586) F 1 NC_006042.1 weakly similar to uniprot|P39929 Saccharomyces cerevisiae YLR025W SNF7 Involved in derepression of SUC2 in response to glucose limitation involved in glucose derepression; ESCRT-III subunit protein SNF7 1631586 2895598 KLLA0_F17820g Kluyveromyces lactis ESCRT-III subunit protein SNF7 XP_455879.1 1630888 R 28985 CDS KLLA0_F17842g 2895599 1633022..1633354 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 1633354 2895599 KLLA0_F17842g Kluyveromyces lactis uncharacterized protein XP_455880.1 1633022 D 28985 CDS KLLA0_F17864g 2895600 complement(1634241..1635164) F 1 NC_006042.1 similar to uniprot|P32331 Saccharomyces cerevisiae YPR058W YMC1 Putative mitochondrial inner membrane transporter member of the mitochondrial carrier (MCF) family; uncharacterized protein 1635164 2895600 KLLA0_F17864g Kluyveromyces lactis uncharacterized protein XP_455881.1 1634241 R 28985 CDS KLLA0_F17886g 2895601 complement(1636432..1637484) F 1 NC_006042.1 similar to uniprot|P40544 Saccharomyces cerevisiae YIL023C; Zn(2+) transporter YKE4 1637484 2895601 KLLA0_F17886g Kluyveromyces lactis Zn(2+) transporter YKE4 XP_455882.1 1636432 R 28985 CDS KLLA0_F17908g 2895602 1637803..1638489 F 1 NC_006042.1 similar to uniprot|Q12354 Saccharomyces cerevisiae YLR118C; palmitoyl-(protein) hydrolase 1638489 2895602 KLLA0_F17908g Kluyveromyces lactis palmitoyl-(protein) hydrolase XP_455883.1 1637803 D 28985 CDS KLLA0_F17930g 2895603 1638931..1643925 F 1 NC_006042.1 similar to uniprot|Q03921 Saccharomyces cerevisiae YDR141C DOP1; uncharacterized protein 1643925 2895603 KLLA0_F17930g Kluyveromyces lactis uncharacterized protein XP_455884.1 1638931 D 28985 CDS KLLA0_F17952g 2895604 complement(1643977..1644645) F 1 NC_006042.1 similar to uniprot|Q03920 Saccharomyces cerevisiae YDR140W MTQ2 Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family methylates release factor eRF1 (Sup45p) in vitro; S-adenosylmethionine-dependent methyltransferase 1644645 2895604 KLLA0_F17952g Kluyveromyces lactis S-adenosylmethionine-dependent methyltransferase XP_455885.1 1643977 R 28985 CDS KLLA0_F17974g 2895582 join(1644903..1645051,1645153..1645237) F 1 NC_006042.1 similar to uniprot|Q03919 Saccharomyces cerevisiae YDR139C RUB1 Ubiquitin-like protein with similarity to mammalian NEDD8; NEDD8 family protein RUB1 1645237 2895582 KLLA0_F17974g Kluyveromyces lactis NEDD8 family protein RUB1 XP_455886.1 1644903 D 28985 CDS KLLA0_F17996g 2895583 1645592..1647646 F 1 NC_006042.1 similar to uniprot|Q12309 Saccharomyces cerevisiae YLR117C CLF1 essential splicesome assembly factor; uncharacterized protein 1647646 2895583 KLLA0_F17996g Kluyveromyces lactis uncharacterized protein XP_455887.1 1645592 D 28985 CDS KLLA0_F18018g 2895584 complement(1647748..1649127) F 1 NC_006042.1 some similarities with uniprot|Q12186 Saccharomyces cerevisiae YLR116W MSL5 Component of the commitment complex which defines the first step in the splicing pathway essential protein that interacts with Mud2p and Prp40p forming a bridge between the intron ends also involved in nuclear retention of pre-mRNA; mRNA splicing protein MSL5 1649127 2895584 KLLA0_F18018g Kluyveromyces lactis mRNA splicing protein MSL5 XP_455888.1 1647748 R 28985 CDS KLLA0_F18040g 2895585 complement(join(1649483..1649917,1650609..1650629)) F 1 NC_006042.1 highly similar to uniprot|P05756 Saccharomyces cerevisiae YDR064W RPS13 Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S15 and rat S13 ribosomal proteins; 40S ribosomal protein uS15 1650629 2895585 KLLA0_F18040g Kluyveromyces lactis 40S ribosomal protein uS15 XP_455889.2 1649483 R 28985 CDS KLLA0_F18062g 2895586 complement(1651147..1651590) F 1 NC_006042.1 similar to uniprot|Q12156 Saccharomyces cerevisiae YDR063W Hypothetical ORF; uncharacterized protein 1651590 2895586 KLLA0_F18062g Kluyveromyces lactis uncharacterized protein XP_455890.1 1651147 R 28985 CDS KLLA0_F18084g 2895587 complement(1652031..1654613) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 1654613 2895587 KLLA0_F18084g Kluyveromyces lactis uncharacterized protein XP_455891.1 1652031 R 28985 CDS KLLA0_F18106g 2895588 1657556..1659325 F 1 NC_006042.1 similar to uniprot|Q07824 Saccharomyces cerevisiae YLL028W TPO1 Proton-motive-force-dependent multidrug transporter of the major facilitator superfamily able to transport eight different compounds including polyamines quinidine cycloheximide and nystatin involved in excess spermidine detoxification; polyamine transporter TPO1 1659325 2895588 KLLA0_F18106g Kluyveromyces lactis polyamine transporter TPO1 XP_455892.1 1657556 D 28985 CDS KLLA0_F18128g 2895589 1661367..1663535 F 1 NC_006042.1 similar to uniprot|Q07825 Saccharomyces cerevisiae YLL029W Hypothetical ORF; aminopeptidase P 1663535 2895589 KLLA0_F18128g Kluyveromyces lactis aminopeptidase P XP_455893.1 1661367 D 28985 CDS KLLA0_F18150g 2895590 1664428..1665123 F 1 NC_006042.1 some similarities with uniprot|Q07821 Saccharomyces cerevisiae YLL027W ISA1 Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency depletion reduces growth on nonfermentable carbon sources; Fe-binding Fe/S cluster assembly protein ISA1 1665123 2895590 KLLA0_F18150g Kluyveromyces lactis Fe-binding Fe/S cluster assembly protein ISA1 XP_455894.1 1664428 D 28985 CDS KLLA0_F18194g 2895592 1668282..1670981 F 1 NC_006042.1 highly similar to uniprot|P31539 Saccharomyces cerevisiae YLL026W HSP104 Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured aggregated proteins responsive to stresses including: heat ethanol and sodium arsenite involved in [PSI ] propagation; chaperone ATPase HSP104 1670981 2895592 KLLA0_F18194g Kluyveromyces lactis chaperone ATPase HSP104 XP_455896.1 1668282 D 28985 CDS KLLA0_F18216g 2895593 1677731..1679857 F 1 NC_006042.1 some similarities with uniprot|P38741 Saccharomyces cerevisiae YHL024W RIM4 Putative RNA-binding protein required for the expression of early and middle sporulation genes; uncharacterized protein 1679857 2895593 KLLA0_F18216g Kluyveromyces lactis uncharacterized protein XP_455897.1 1677731 D 28985 CDS KLLA0_F18238g 2895594 complement(1680299..1682833) F 1 NC_006042.1 some similarities with uniprot|P38742 Saccharomyces cerevisiae YHL023C RMD11 Protein required for sporulation; uncharacterized protein 1682833 2895594 KLLA0_F18238g Kluyveromyces lactis uncharacterized protein XP_455898.1 1680299 R 28985 CDS KLLA0_F18260g 2894942 complement(1683417..1684463) F 1 NC_006042.1 uniprot|P49383 Kluyveromyces lactis KLLA0F18260g ADH2 Alcohol dehydrogenase 2; uncharacterized protein 1684463 2894942 KLLA0_F18260g Kluyveromyces lactis uncharacterized protein XP_455899.1 1683417 R 28985 CDS KLLA0_F18282g 2895595 1686456..1689005 F 1 NC_006042.1 similar to uniprot|P05374 Saccharomyces cerevisiae YGR157W CHO2 First step in the methylation pathway for phosphatidylcholine biosynthesis Phosphatidyl-ethanolamine N-methyltransferase; phosphatidylethanolamine N-methyltransferase 1689005 2895595 KLLA0_F18282g Kluyveromyces lactis phosphatidylethanolamine N-methyltransferase XP_455900.1 1686456 D 28985 CDS KLLA0_F18304g 2895568 complement(1689187..1689897) F 1 NC_006042.1 similar to uniprot|P48240 Saccharomyces cerevisiae YGR158C MTR3 3'5' exoribonuclease exosome subunit nucleolar protein involved in export of mRNA and ribosomal subunits homologous to the E. coli exonuclease RNase PH; exosome non-catalytic core subunit MTR3 1689897 2895568 KLLA0_F18304g Kluyveromyces lactis exosome non-catalytic core subunit MTR3 XP_455901.1 1689187 R 28985 CDS KLLA0_F18370g 2895571 1692172..1692711 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 1692711 2895571 KLLA0_F18370g Kluyveromyces lactis uncharacterized protein XP_455903.1 1692172 D 28985 CDS KLLA0_F18392g 2895572 1693928..1695694 F 1 NC_006042.1 highly similar to uniprot|P15180 Saccharomyces cerevisiae YDR037W KRS1 Lysyl-tRNA synthetase also identified as a negative regulator of general control of amino acid biosynthesis; lysine--tRNA ligase KRS1 1695694 2895572 KLLA0_F18392g Kluyveromyces lactis lysine--tRNA ligase KRS1 XP_455904.1 1693928 D 28985 CDS KLLA0_F18414g 2895573 complement(1695869..1696774) F 1 NC_006042.1 similar to uniprot|P38238 Saccharomyces cerevisiae YBR061C TRM7 2'-O-ribose methyltransferase methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop; tRNA methyltransferase TRM7 1696774 2895573 KLLA0_F18414g Kluyveromyces lactis tRNA methyltransferase TRM7 XP_455905.1 1695869 R 28985 CDS KLLA0_F18436g 2895574 1697109..1697732 F 1 NC_006042.1 similar to uniprot|Q03201 Saccharomyces cerevisiae YDR041W RSM10 Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins; mitochondrial 37S ribosomal protein uS10m 1697732 2895574 KLLA0_F18436g Kluyveromyces lactis mitochondrial 37S ribosomal protein uS10m XP_455906.1 1697109 D 28985 CDS KLLA0_F18458g 2895575 complement(1697871..1698293) F 1 NC_006042.1 similar to uniprot|P38239 Saccharomyces cerevisiae YBR062C Hypothetical ORF; uncharacterized protein 1698293 2895575 KLLA0_F18458g Kluyveromyces lactis uncharacterized protein XP_455907.1 1697871 R 28985 CDS KLLA0_F18480g 2895576 complement(1698689..1699180) F 1 NC_006042.1 no similarity; uncharacterized protein 1699180 2895576 KLLA0_F18480g Kluyveromyces lactis uncharacterized protein XP_455908.1 1698689 R 28985 CDS KLLA0_F18502g 2895577 complement(1699447..1700355) F 1 NC_006042.1 weakly similar to uniprot|P38241 Saccharomyces cerevisiae YBR065C ECM2 Pre-mRNA splicing factor facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome function may be regulated by Slu7p; uncharacterized protein 1700355 2895577 KLLA0_F18502g Kluyveromyces lactis uncharacterized protein XP_455909.1 1699447 R 28985 CDS KLLA0_F18524g 2895578 complement(1701498..1702571) F 1 NC_006042.1 some similarities with uniprot|Q03125 Saccharomyces cerevisiae YDR043C NRG1 Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; uncharacterized protein 1702571 2895578 KLLA0_F18524g Kluyveromyces lactis uncharacterized protein XP_455910.1 1701498 R 28985 CDS KLLA0_F18546g 2895579 1706744..1707871 F 1 NC_006042.1 uniprot|Q70W35 Kluyveromyces lactis putative coproporphyrinogen oxidase; coproporphyrinogen oxidase 1707871 2895579 KLLA0_F18546g Kluyveromyces lactis coproporphyrinogen oxidase XP_455911.1 1706744 D 28985 CDS KLLA0_F18568g 2895580 complement(1708319..1708657) F 1 NC_006042.1 highly similar to uniprot|Q04307 YDR045C Saccharomyces cerevisiae RPC11 RNA polymerase III subunit C11; DNA-directed RNA polymerase III core subunit RPC11 1708657 2895580 KLLA0_F18568g Kluyveromyces lactis DNA-directed RNA polymerase III core subunit RPC11 XP_455912.1 1708319 R 28985 CDS KLLA0_F18590g 2895581 1709034..1710824 F 1 NC_006042.1 similar to uniprot|P32833 YBR060C Saccharomyces cerevisiae ORC2 Subunit of the origin recognition complex; origin recognition complex subunit 2 1710824 2895581 KLLA0_F18590g Kluyveromyces lactis origin recognition complex subunit 2 XP_455913.1 1709034 D 28985 CDS KLLA0_F18612g 2895556 1711131..1713575 F 1 NC_006042.1 some similarities with uniprot|P38080 Saccharomyces cerevisiae YBR059C AKL1 Serine-threonine protein kinase member (with Ark1p and Prk1p) of the Ark kinase family; serine/threonine protein kinase AKL1 1713575 2895556 KLLA0_F18612g Kluyveromyces lactis serine/threonine protein kinase AKL1 XP_455914.1 1711131 D 28985 CDS KLLA0_F18634g 2895557 1713947..1714201 F 1 NC_006042.1 similar to uniprot|Q3E790 Saccharomyces cerevisiae YBR058C-A TSC3 Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p,Lcb2p) several-fold; involved in sphingolipid biosynthesis; uncharacterized protein 1714201 2895557 KLLA0_F18634g Kluyveromyces lactis uncharacterized protein XP_455915.1 1713947 D 28985 CDS KLLA0_F18656g 2895558 complement(1714588..1715742) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 1715742 2895558 KLLA0_F18656g Kluyveromyces lactis uncharacterized protein XP_455916.1 1714588 R 28985 CDS KLLA0_F18678g 2895559 1716890..1718404 F 1 NC_006042.1 similar to uniprot|P28817 YDR036C Saccharomyces cerevisiae EHD3 Protein of unconfirmed function plays an indirect role in endocytic membrane trafficking member of a family of enoyl-CoA hydratase/isomerases; mitochondrial 37S ribosomal protein mS47 1718404 2895559 KLLA0_F18678g Kluyveromyces lactis mitochondrial 37S ribosomal protein mS47 XP_455917.1 1716890 D 28985 CDS KLLA0_F18700g 2895560 1718738..1721050 F 1 NC_006042.1 similar to uniprot|P38237 YBR058C Saccharomyces cerevisiae UBP14 Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; ubiquitin-specific protease UBP14 1721050 2895560 KLLA0_F18700g Kluyveromyces lactis ubiquitin-specific protease UBP14 XP_455918.1 1718738 D 28985 CDS KLLA0_F18722g 2895561 1721734..1722546 F 1 NC_006042.1 some similarities with uniprot|P38236 YBR057C Saccharomyces cerevisiae MUM2 Cytoplasmic protein essential for meiotic DNA replication and sporulation; uncharacterized protein 1722546 2895561 KLLA0_F18722g Kluyveromyces lactis uncharacterized protein XP_455919.1 1721734 D 28985 CDS KLLA0_F18744g 2895562 complement(1723008..1724126) F 1 NC_006042.1 highly similar to uniprot|P14843 YDR035W Saccharomyces cerevisiae ARO3 3-deoxy-D-arabino-heptulosonate-7- phosphate (DAHP) synthase; 3-deoxy-7-phosphoheptulonate synthase ARO3 1724126 2895562 KLLA0_F18744g Kluyveromyces lactis 3-deoxy-7-phosphoheptulonate synthase ARO3 XP_455920.1 1723008 R 28985 CDS KLLA0_F18766g 2895563 complement(1725142..1725348) F 1 NC_006042.1 similar to uniprot|Q6Q5X2 Saccharomyces cerevisiae YDR034W-B Protein of unknown function; green fluorescent protein (GFP)-fusion protein; uncharacterized protein 1725348 2895563 KLLA0_F18766g Kluyveromyces lactis uncharacterized protein XP_455921.1 1725142 R 28985 CDS KLLA0_F18788g 2895564 complement(1726046..1727515) F 1 NC_006042.1 similar to uniprot|P38081 YBR056W Saccharomyces cerevisiae Hypothetical ORF; 17-beta-hydroxysteroid dehydrogenase-like protein 1727515 2895564 KLLA0_F18788g Kluyveromyces lactis 17-beta-hydroxysteroid dehydrogenase-like protein XP_455922.1 1726046 R 28985 CDS KLLA0_F18810g 2895565 1728000..1728941 F 1 NC_006042.1 similar to uniprot|Q7LHX4 Saccharomyces cerevisiae YDR051C Hypothetical ORF; acid phosphatase DET1 1728941 2895565 KLLA0_F18810g Kluyveromyces lactis acid phosphatase DET1 XP_455923.1 1728000 D 28985 CDS KLLA0_F18832g 2895566 1729736..1730482 F 1 NC_006042.1 highly similar to uniprot|P00942 Saccharomyces cerevisiae YDR050C TPI1 induced under stress conditions triosephosphate isomerase; triose-phosphate isomerase TPI1 1730482 2895566 KLLA0_F18832g Kluyveromyces lactis triose-phosphate isomerase TPI1 XP_455924.2 1729736 D 28985 CDS KLLA0_F18865g 2895545 complement(1730609..1731319) F 1 NC_006042.1 similar to uniprot|P38242 Saccharomyces cerevisiae YBR070C ALG14 Essential protein required for the second step of dolichyl-linked oligosaccharide synthesis; involved in N-linked glycosylation; similar to bacterial glycosyltransferases; N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase anchoring subunit ALG14 1731319 2895545 KLLA0_F18865g Kluyveromyces lactis N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase anchoring subunit ALG14 XP_455926.1 1730609 R 28985 CDS KLLA0_F18887g 2895546 1732170..1732529 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 1732529 2895546 KLLA0_F18887g Kluyveromyces lactis uncharacterized protein XP_455927.1 1732170 D 28985 CDS KLLA0_F18909g 2895547 1733468..1734058 F 1 NC_006042.1 similar to uniprot|P15992 Saccharomyces cerevisiae YBR072W HSP26 Small heat shock protein with chaperone activity that is regulated by a heat induced transition from an inactive oligomeric (24-mer) complex to an active dimer induced by heat upon entry into stationary phase and during sporulation; chaperone protein HSP26 1734058 2895547 KLLA0_F18909g Kluyveromyces lactis chaperone protein HSP26 XP_455928.1 1733468 D 28985 CDS KLLA0_F18931g 2895548 complement(1734636..1736633) F 1 NC_006042.1 similar to uniprot|P32802 Saccharomyces cerevisiae YLR083C EMP70 Protein whose 24kDa cleavage product is found in endosome-enriched membrane fractions predicted to be a transmembrane protein; uncharacterized protein 1736633 2895548 KLLA0_F18931g Kluyveromyces lactis uncharacterized protein XP_455929.1 1734636 R 28985 CDS KLLA0_F18953g 2895549 1737522..1739465 F 1 NC_006042.1 similar to uniprot|P46944 Saccharomyces cerevisiae YDR108W GSG1 Subunit of TRAPP (transport protein particle) a multi-subunit complex involved in targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment protein has late meiotic role following DNA replication; uncharacterized protein 1739465 2895549 KLLA0_F18953g Kluyveromyces lactis uncharacterized protein XP_455930.1 1737522 D 28985 CDS KLLA0_F18975g 2895550 complement(1739543..1743145) F 1 NC_006042.1 similar to uniprot|Q12465 Saccharomyces cerevisiae YLR084C RAX2 N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding localization requires Rax1p; uncharacterized protein 1743145 2895550 KLLA0_F18975g Kluyveromyces lactis uncharacterized protein XP_455931.1 1739543 R 28985 CDS KLLA0_F18997g 2895551 complement(1747295..1748497) F 1 NC_006042.1 some similarities with uniprot|Q74ZV5 Ashbya gossypii AGR094W AGR094Wp; uncharacterized protein 1748497 2895551 KLLA0_F18997g Kluyveromyces lactis uncharacterized protein XP_455932.1 1747295 R 28985 CDS KLLA0_F19041g 2895553 complement(1753543..1755834) F 1 NC_006042.1 similar to uniprot|Q04585 Saccharomyces cerevisiae YDR109C Hypothetical ORF; uncharacterized protein 1755834 2895553 KLLA0_F19041g Kluyveromyces lactis uncharacterized protein XP_455934.1 1753543 R 28985 CDS KLLA0_F19063g 2895554 complement(1756529..1757776) F 1 NC_006042.1 similar to uniprot|Q12509 Saccharomyces cerevisiae YLR085C ARP6 Nuclear actin-related protein involved in chromatin remodeling component of chromatin-remodeling enzyme complexes; uncharacterized protein 1757776 2895554 KLLA0_F19063g Kluyveromyces lactis uncharacterized protein XP_455935.1 1756529 R 28985 CDS KLLA0_F19085g 2895555 1758111..1762229 F 1 NC_006042.1 similar to uniprot|Q12267 Saccharomyces cerevisiae YLR086W SMC4 subunit of the condensin complex which reorganizes chromosomes during cell division; condensin subunit SMC4 1762229 2895555 KLLA0_F19085g Kluyveromyces lactis condensin subunit SMC4 XP_455936.1 1758111 D 28985 CDS KLLA0_F19096g 2895531 complement(1762215..1770986) F 1 NC_006042.1 similar to uniprot|Q12150 Saccharomyces cerevisiae YLR087C CSF1 Protein required for fermentation at low temperature; uncharacterized protein 1770986 2895531 KLLA0_F19096g Kluyveromyces lactis uncharacterized protein XP_455937.1 1762215 R 28985 CDS KLLA0_F19118g 2895532 1771250..1772986 F 1 NC_006042.1 similar to uniprot|P39012 Saccharomyces cerevisiae YLR088W GAA1 Subunit of the GPI:protein transamidase complex removes the GPI-anchoring signal and attaches GPI (glycosylphosphatidylinositol) to proteins in the ER; GPI-anchor transamidase subunit GAA1 1772986 2895532 KLLA0_F19118g Kluyveromyces lactis GPI-anchor transamidase subunit GAA1 XP_455938.1 1771250 D 28985 CDS KLLA0_F19140g 2895533 1773327..1774910 F 1 NC_006042.1 some similarities with uniprot|O13329 Saccharomyces cerevisiae YDR110W FOB1 Nucleolar protein required for DNA replication fork blocking and recombinational hotspot activities binds to the replication fork barrier site in the rDNA region related to retroviral integrases; replication fork barrier binding protein FOB1 1774910 2895533 KLLA0_F19140g Kluyveromyces lactis replication fork barrier binding protein FOB1 XP_455939.1 1773327 D 28985 CDS KLLA0_F19162g 2895534 complement(1775240..1776826) F 1 NC_006042.1 similar to uniprot|P52893 Saccharomyces cerevisiae YLR089C ALT1 putative alanine transaminase (glutamyc pyruvic transaminase); uncharacterized protein 1776826 2895534 KLLA0_F19162g Kluyveromyces lactis uncharacterized protein XP_455940.1 1775240 R 28985 CDS KLLA0_F19184g 2895535 1778227..1779765 F 1 NC_006042.1 similar to uniprot|P39102 Saccharomyces cerevisiae YLR090W XDJ1 Putative homolog of E. coli DnaJ closely related to Ydj1p; uncharacterized protein 1779765 2895535 KLLA0_F19184g Kluyveromyces lactis uncharacterized protein XP_455941.1 1778227 D 28985 CDS KLLA0_F19206g 2895536 complement(1780093..1780884) F 1 NC_006042.1 weakly similar to uniprot|P40316 Saccharomyces cerevisiae YDR113C PDS1 Securin that inhibits anaphase by binding separin Esp1p also blocks cyclin destruction and mitotic exit essential for cell cycle arrest in mitosis in the presence of DNA damage or aberrant mitotic spindles also present in meiotic nuclei; securin 1780884 2895536 KLLA0_F19206g Kluyveromyces lactis securin XP_455942.1 1780093 R 28985 CDS KLLA0_F19228g 2895537 1781494..1782411 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 1782411 2895537 KLLA0_F19228g Kluyveromyces lactis uncharacterized protein XP_455943.1 1781494 D 28985 CDS KLLA0_F19250g 2895538 1782824..1783174 F 1 NC_006042.1 similar to uniprot|Q04598 Saccharomyces cerevisiae YDR115W; mitochondrial 54S ribosomal protein bL34m 1783174 2895538 KLLA0_F19250g Kluyveromyces lactis mitochondrial 54S ribosomal protein bL34m XP_455944.1 1782824 D 28985 CDS KLLA0_F19272g 2895539 complement(1783497..1784297) F 1 NC_006042.1 similar to uniprot|Q04599 Saccharomyces cerevisiae YDR116C MRPL1 Mitochondrial ribosomal protein of the large subunit; mitochondrial 54S ribosomal protein uL1m 1784297 2895539 KLLA0_F19272g Kluyveromyces lactis mitochondrial 54S ribosomal protein uL1m XP_455945.1 1783497 R 28985 CDS KLLA0_F19294g 2895540 complement(1784664..1786376) F 1 NC_006042.1 similar to uniprot|Q04600 Saccharomyces cerevisiae YDR117C RBF64 Hypothetical ORF; uncharacterized protein 1786376 2895540 KLLA0_F19294g Kluyveromyces lactis uncharacterized protein XP_455946.1 1784664 R 28985 CDS KLLA0_F19316g 2895541 1786659..1788674 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 1788674 2895541 KLLA0_F19316g Kluyveromyces lactis uncharacterized protein XP_455947.1 1786659 D 28985 CDS KLLA0_F19338g 2895542 1789536..1792211 F 1 NC_006042.1 similar to uniprot|P38359 Saccharomyces cerevisiae YBR294W SUL1 High affinity sulfate permease sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p which control the concentration of endogenous activated sulfate intermediates and uniprot|Q12325 Saccharomyces cerevisiae YLR092W SUL2; sulfate permease 1792211 2895542 KLLA0_F19338g Kluyveromyces lactis sulfate permease XP_455948.1 1789536 D 28985 CDS KLLA0_F19360g 2895543 1792778..1793812 F 1 NC_006042.1 highly similar to uniprot|Q02895 Saccharomyces cerevisiae YPL088W Putative aryl alcohol dehydrogenase transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; aldo-keto reductase superfamily protein 1793812 2895543 KLLA0_F19360g Kluyveromyces lactis aldo-keto reductase superfamily protein XP_455949.1 1792778 D 28985 CDS KLLA0_F19371g 9487278 1794714..1794956 F 1 NC_006042.1 some similarities with uniprot|Q2V2P9 Saccharomyces cerevisiae YDR119W-A Pi; uncharacterized protein 1794956 9487278 KLLA0_F19371g Kluyveromyces lactis uncharacterized protein XP_002999435.1 1794714 D 28985 CDS KLLA0_F19382g 2895544 1795951..1796178 F 1 NC_006042.1 some similarities with uniprot|Q2V2P9 Saccharomyces cerevisiae YDR119W-A Pi; uncharacterized protein 1796178 2895544 KLLA0_F19382g Kluyveromyces lactis uncharacterized protein XP_455950.2 1795951 D 28985 CDS KLLA0_F19404g 2895511 complement(1796569..1798242) F 1 NC_006042.1 similar to uniprot|P15565 Saccharomyces cerevisiae YDR120C TRM1 tRNA methyltransferase localizes to both the nucleus and mitochondrion to produce the modified base N2 N2-dimethylguanosine in tRNAs in both compartments; tRNA (guanine26-N2)-dimethyltransferase 1798242 2895511 KLLA0_F19404g Kluyveromyces lactis tRNA (guanine26-N2)-dimethyltransferase XP_455951.1 1796569 R 28985 CDS KLLA0_F19426g 2895512 1798814..1799464 F 1 NC_006042.1 similar to uniprot|Q04603 Saccharomyces cerevisiae YDR121W DPB4 Shared subunit of DNA polymerase epsilon and of ISW2/yCHRAC chromatin accessibility complex involved in both chromosomal DNA replication and in inheritance of telomeric silencing; DNA polymerase epsilon noncatalytic subunit 1799464 2895512 KLLA0_F19426g Kluyveromyces lactis DNA polymerase epsilon noncatalytic subunit XP_455952.1 1798814 D 28985 CDS KLLA0_F19448g 2895513 complement(1799571..1800266) F 1 NC_006042.1 similar to uniprot|Q12255 Saccharomyces cerevisiae YLR093C NYV1 v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion inhibits ATP-dependent Ca(2) transport activity of Pmc1p in the vacuolar membrane; uncharacterized protein 1800266 2895513 KLLA0_F19448g Kluyveromyces lactis uncharacterized protein XP_455953.1 1799571 R 28985 CDS KLLA0_F19470g 2895514 complement(1800700..1802205) F 1 NC_006042.1 similar to uniprot|Q750A2 Ashbya gossypii AGR055C AGR055Cp and some similarities with YHR176W uniprot|P38866 Saccharomyces cerevisiae YHR176W FMO1 Flavin-containing monooxygenase localized to the cytoplasmic face of the ER membrane catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins; uncharacterized protein 1802205 2895514 KLLA0_F19470g Kluyveromyces lactis uncharacterized protein XP_455954.1 1800700 R 28985 CDS KLLA0_F19492g 2895515 complement(1803008..1804366) F 1 NC_006042.1 some similarities with uniprot|Q7LGX3 Saccharomyces cerevisiae YLR094C GIS3 Protein of unknown function; uncharacterized protein 1804366 2895515 KLLA0_F19492g Kluyveromyces lactis uncharacterized protein XP_455955.1 1803008 R 28985 CDS KLLA0_F19514g 2895516 complement(1804838..1807057) F 1 NC_006042.1 similar to uniprot|Q12072 Saccharomyces cerevisiae YLR095C IOC2 Member of a complex (Isw1b) with Isw1p and Ioc4p; uncharacterized protein 1807057 2895516 KLLA0_F19514g Kluyveromyces lactis uncharacterized protein XP_455956.1 1804838 R 28985 CDS KLLA0_F19536g 2895517 1808263..1811577 F 1 NC_006042.1 similar to uniprot|P13186 Saccharomyces cerevisiae YLR096W KIN2 Serine/threonine protein kinase involved in regulation of exocytosis localizes to the cytoplasmic face of the plasma membrane closely related to Kin1p and to YDR122W uniprot|P13185 Saccharomyces cerevisiae YDR122W KIN1 Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p; uncharacterized protein 1811577 2895517 KLLA0_F19536g Kluyveromyces lactis uncharacterized protein XP_455957.1 1808263 D 28985 CDS KLLA0_F19558g 2895518 complement(1811729..1812886) F 1 NC_006042.1 weakly similar to uniprot|P26798 Saccharomyces cerevisiae YDR123C INO2 Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs) required for derepression of phospholipid biosynthetic genes in response to inositol depletion; uncharacterized protein 1812886 2895518 KLLA0_F19558g Kluyveromyces lactis uncharacterized protein XP_455958.1 1811729 R 28985 CDS KLLA0_F19580g 2895519 complement(1813462..1814511) F 1 NC_006042.1 similar to uniprot|Q12347 Saccharomyces cerevisiae YLR097C HRT3 Putative nuclear ubiquitin ligase based on computational analysis of large-scale protein-protein interaction data; SCF ubiquitin ligase complex subunit HRT3 1814511 2895519 KLLA0_F19580g Kluyveromyces lactis SCF ubiquitin ligase complex subunit HRT3 XP_455959.1 1813462 R 28985 CDS KLLA0_F19602g 2895520 complement(1814949..1816760) F 1 NC_006042.1 similar to uniprot|P43634 Saccharomyces cerevisiae YLR098C CHA4 Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain DNA-binding transcriptional activator or CHA1 and some similarities to YOR337W uniprot|P47988 Saccharomyces cerevisiae YOR337W TEA1 Mutants are defective in Ty1 Enhancer-mediated Activation Ty1 enhancer activator; uncharacterized protein 1816760 2895520 KLLA0_F19602g Kluyveromyces lactis uncharacterized protein XP_455960.1 1814949 R 28985 CDS KLLA0_F19624g 2895521 complement(1817206..1818435) F 1 NC_006042.1 similar to uniprot|Q04623 Saccharomyces cerevisiae YDR125C ECM18 Protein of unknown function, similar to Rlp24p; lysophosphatidic acid acyltransferase ICT1 1818435 2895521 KLLA0_F19624g Kluyveromyces lactis lysophosphatidic acid acyltransferase ICT1 XP_455961.1 1817206 R 28985 CDS KLLA0_F19646g 2895522 1818898..1819257 F 1 NC_006042.1 some similarities with uniprot|Q3E798 Saccharomyces cerevisiae YLR099W-A Hypothetical ORF; uncharacterized protein 1819257 2895522 KLLA0_F19646g Kluyveromyces lactis uncharacterized protein XP_455962.1 1818898 D 28985 CDS KLLA0_F19668g 2895523 complement(1819417..1819905) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 1819905 2895523 KLLA0_F19668g Kluyveromyces lactis uncharacterized protein XP_455963.1 1819417 R 28985 CDS KLLA0_F19690g 2895524 1820355..1821329 F 1 NC_006042.1 similar to uniprot|Q04629 Saccharomyces cerevisiae YDR126W SWF1 Spore Wall Formation; palmitoyltransferase SWF1 1821329 2895524 KLLA0_F19690g Kluyveromyces lactis palmitoyltransferase SWF1 XP_455964.1 1820355 D 28985 CDS KLLA0_F19712g 2895525 1821832..1826568 F 1 NC_006042.1 highly similar to uniprot|P08566 Saccharomyces cerevisiae YDR127W ARO1 Pentafunctional arom protein catalyzes steps 2 through 6 in the biosynthesis of chorismate which is a precursor to aromatic amino acids; pentafunctional protein ARO1p 1826568 2895525 KLLA0_F19712g Kluyveromyces lactis pentafunctional protein ARO1p XP_455965.1 1821832 D 28985 CDS KLLA0_F19734g 2895501 1826828..1830229 F 1 NC_006042.1 similar to uniprot|Q03897 Saccharomyces cerevisiae YDR128W Hypothetical ORF; uncharacterized protein 1830229 2895501 KLLA0_F19734g Kluyveromyces lactis uncharacterized protein XP_455966.1 1826828 D 28985 CDS KLLA0_F19756g 2895502 1830489..1831529 F 1 NC_006042.1 highly similar to uniprot|Q12452 Saccharomyces cerevisiae YLR100W ERG27 3-keto sterol reductase catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis mutants are sterol auxotrophs; 3-keto-steroid reductase 1831529 2895502 KLLA0_F19756g Kluyveromyces lactis 3-keto-steroid reductase XP_455967.1 1830489 D 28985 CDS KLLA0_F19778g 2895503 complement(1831727..1833700) F 1 NC_006042.1 highly similar to uniprot|P32599 Saccharomyces cerevisiae YDR129C SAC6 Fimbrin actin-bundling protein cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; fimbrin 1833700 2895503 KLLA0_F19778g Kluyveromyces lactis fimbrin XP_455968.1 1831727 R 28985 CDS KLLA0_F19800g 2895504 complement(1834144..1834698) F 1 NC_006042.1 no similarity; uncharacterized protein 1834698 2895504 KLLA0_F19800g Kluyveromyces lactis uncharacterized protein XP_455969.1 1834144 R 28985 CDS KLLA0_F19822g 2895505 complement(1835015..1837009) F 1 NC_006042.1 similar to uniprot|Q08032 Saccharomyces cerevisiae YLR103C CDC45 DNA replication initiation factor; DNA replication initiation factor CDC45 1837009 2895505 KLLA0_F19822g Kluyveromyces lactis DNA replication initiation factor CDC45 XP_455970.1 1835015 R 28985 CDS KLLA0_F19844g 2895506 1837295..1837699 F 1 NC_006042.1 similar to uniprot|Q08045 Saccharomyces cerevisiae YLR104W Hypothetical ORF; uncharacterized protein 1837699 2895506 KLLA0_F19844g Kluyveromyces lactis uncharacterized protein XP_455971.1 1837295 D 28985 CDS KLLA0_F19866g 2895507 complement(1837874..1838983) F 1 NC_006042.1 similar to uniprot|P16658 Saccharomyces cerevisiae YLR105C; tRNA splicing endonuclease subunit SEN2 1838983 2895507 KLLA0_F19866g Kluyveromyces lactis tRNA splicing endonuclease subunit SEN2 XP_455972.1 1837874 R 28985 CDS KLLA0_F19888g 2895508 complement(1839682..1854429) F 1 NC_006042.1 similar to uniprot|Q12019 Saccharomyces cerevisiae YLR106C MDN1 Huge dynein-related AAA-type ATPase (midasin) forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p) may mediate ATP-dependent remodeling of 60S subunits and subsequent export from nucleoplasm to cytoplasm; AAA family ATPase midasin 1854429 2895508 KLLA0_F19888g Kluyveromyces lactis AAA family ATPase midasin XP_455973.1 1839682 R 28985 CDS KLLA0_F19910g 2895510 1854593..1856029 F 1 NC_006042.1 similar to uniprot|Q12090 Saccharomyces cerevisiae YLR107W REX3 RNA exonuclease required for maturation of the RNA component of RNase MRP; RNA exonuclease 1856029 2895510 KLLA0_F19910g Kluyveromyces lactis RNA exonuclease XP_455974.1 1854593 D 28985 CDS KLLA0_F19921g 2895486 complement(1856021..1856719) F 1 NC_006042.1 some similarities with uniprot|Q03898 Saccharomyces cerevisiae YDR130C FIN1 Basic protein with putative coiled-coil regions that comprises a filament between spindle pole bodies; uncharacterized protein 1856719 2895486 KLLA0_F19921g Kluyveromyces lactis uncharacterized protein XP_455975.1 1856021 R 28985 CDS KLLA0_F19943g 2895487 complement(1856924..1858504) F 1 NC_006042.1 weakly similar to uniprot|Q03899 Saccharomyces cerevisiae YDR131C Hypothetical ORF; uncharacterized protein 1858504 2895487 KLLA0_F19943g Kluyveromyces lactis uncharacterized protein XP_455976.1 1856924 R 28985 CDS KLLA0_F19965g 2895488 complement(1859394..1860752) F 1 NC_006042.1 similar to uniprot|Q03900 Saccharomyces cerevisiae YDR132C Hypothetical ORF; uncharacterized protein 1860752 2895488 KLLA0_F19965g Kluyveromyces lactis uncharacterized protein XP_455977.1 1859394 R 28985 CDS KLLA0_F20009g 2895490 1862310..1862825 F 1 NC_006042.1 similar to uniprot|P38013 Saccharomyces cerevisiae YLR109W AHP1 Thiol-specific peroxiredoxin reduces hydroperoxides to protect against oxidative damage function in vivo requires covalent conjugation to Urm1p; thioredoxin peroxidase AHP1 1862825 2895490 KLLA0_F20009g Kluyveromyces lactis thioredoxin peroxidase AHP1 XP_455979.1 1862310 D 28985 CDS KLLA0_F20031g 2895491 complement(1863884..1864258) F 1 NC_006042.1 some similarities with uniprot|Q12127 Saccharomyces cerevisiae YLR110C CCW12 Cell wall protein; uncharacterized protein 1864258 2895491 KLLA0_F20031g Kluyveromyces lactis uncharacterized protein XP_455980.1 1863884 R 28985 CDS KLLA0_F20053g 2895492 1867209..1868543 F 1 NC_006042.1 highly similar to uniprot|P32485 Saccharomyces cerevisiae YLR113W HOG1 Mitogen-activated protein kinase involved in osmoregulation; mitogen-activated protein kinase HOG1 1868543 2895492 KLLA0_F20053g Kluyveromyces lactis mitogen-activated protein kinase HOG1 XP_455981.1 1867209 D 28985 CDS KLLA0_F20075g 2895493 complement(1868786..1873336) F 1 NC_006042.1 similar to uniprot|P39109 Saccharomyces cerevisiae YDR135C; ATP-binding cassette glutathione S-conjugate transporter YCF1 1873336 2895493 KLLA0_F20075g Kluyveromyces lactis ATP-binding cassette glutathione S-conjugate transporter YCF1 XP_455982.1 1868786 R 28985 CDS KLLA0_F20119g 2895495 1874062..1877319 F 1 NC_006042.1 similar to uniprot|Q06156 Saccharomyces cerevisiae YLR272C YCS4 Protein required for accurate sister chromatid segregation; condensin subunit YCS4 1877319 2895495 KLLA0_F20119g Kluyveromyces lactis condensin subunit YCS4 XP_455983.1 1874062 D 28985 CDS KLLA0_F20141g 2895496 complement(1877664..1878839) F 1 NC_006042.1 highly similar to uniprot|P16622 Saccharomyces cerevisiae YOR176W HEM15 Ferrochelatase a mitochondrial inner membrane protein catalyzes the insertion of ferrous iron into protoporphyrin IX the eighth and final step in the heme biosynthetic pathway Yfh1p mediates the use of iron by Hem15p; ferrochelatase HEM15 1878839 2895496 KLLA0_F20141g Kluyveromyces lactis ferrochelatase HEM15 XP_455984.1 1877664 R 28985 CDS KLLA0_F20163g 2895497 1880075..1881922 F 1 NC_006042.1 similar to uniprot|Q03130 Saccharomyces cerevisiae YOR175C Hypothetical ORF; lysophospholipid acyltransferase 1881922 2895497 KLLA0_F20163g Kluyveromyces lactis lysophospholipid acyltransferase XP_455985.1 1880075 D 28985 CDS KLLA0_F20185g 2895498 complement(1882094..1882951) F 1 NC_006042.1 similar to uniprot|Q12343 Saccharomyces cerevisiae YOR174W MED4 Member of RNA Polymerase II transcriptional regulation mediator Stoichiometric member of mediator complex; uncharacterized protein 1882951 2895498 KLLA0_F20185g Kluyveromyces lactis uncharacterized protein XP_455986.1 1882094 R 28985 CDS KLLA0_F20207g 2895499 complement(1883230..1884093) F 1 NC_006042.1 weakly similar to uniprot|Q06152 Saccharomyces cerevisiae YLR271W Hypothetical ORF; uncharacterized protein 1884093 2895499 KLLA0_F20207g Kluyveromyces lactis uncharacterized protein XP_455987.1 1883230 R 28985 CDS KLLA0_F20229g 2895500 complement(1884343..1885395) F 1 NC_006042.1 highly similar to uniprot|Q6Q5L1 Saccharomyces cerevisiae YLR270W DCS1 Non-essential hydrolase involved in mRNA decapping may function in a feedback mechanism to regulate deadenylation contains pyrophosphatase activity and a HIT (histidine triad) motif interacts with neutral trehalase Nth1p; uncharacterized protein 1885395 2895500 KLLA0_F20229g Kluyveromyces lactis uncharacterized protein XP_455988.1 1884343 R 28985 CDS KLLA0_F20251g 2895472 complement(1885728..1886372) F 1 NC_006042.1 similar to uniprot|P22214 Saccharomyces cerevisiae YLR268W SEC22 R-SNARE protein assembles into SNARE complex with Bet1p Bos1p and Sed5p cycles between the ER and Golgi complex involved in anterograde and retrograde transport between the ER and Golgi synaptobrevin homolog; SNAP receptor SEC22 1886372 2895472 KLLA0_F20251g Kluyveromyces lactis SNAP receptor SEC22 XP_455989.1 1885728 R 28985 CDS KLLA0_F20273g 2895473 1886914..1887453 F 1 NC_006042.1 similar to uniprot|Q99321 Saccharomyces cerevisiae YOR163W DDP1 Diadenosine polyphosphate hydrolase member of the MutT family of nucleotide hydrolases with high specificity for diadenosine hexa- and pentaphosphates required for efficient hydrolysis of diphosphorylated inositol polyphosphates; polyphosphatase DDP1 1887453 2895473 KLLA0_F20273g Kluyveromyces lactis polyphosphatase DDP1 XP_455990.1 1886914 D 28985 CDS KLLA0_F20295g 2895474 complement(1887496..1888404) F 1 NC_006042.1 similar to uniprot|Q12125 Saccharomyces cerevisiae YOR164C Hypothetical ORF; uncharacterized protein 1888404 2895474 KLLA0_F20295g Kluyveromyces lactis uncharacterized protein XP_455991.1 1887496 R 28985 CDS KLLA0_F20317g 2895475 1888803..1891163 F 1 NC_006042.1 similar to uniprot|Q99287 Saccharomyces cerevisiae YOR165W SEY1 Synthetic Enhancement with YOP1; dynamin-like GTPase SEY1 1891163 2895475 KLLA0_F20317g Kluyveromyces lactis dynamin-like GTPase SEY1 XP_455992.1 1888803 D 28985 CDS KLLA0_F20339g 2895476 1891435..1892337 F 1 NC_006042.1 no similarity; uncharacterized protein 1892337 2895476 KLLA0_F20339g Kluyveromyces lactis uncharacterized protein XP_455993.1 1891435 D 28985 CDS KLLA0_F20361g 2895477 complement(1892426..1893769) F 1 NC_006042.1 some similarities with uniprot|Q12104 Saccharomyces cerevisiae YOR166C Hypothetical ORF; mRNA-processing endoribonuclease 1893769 2895477 KLLA0_F20361g Kluyveromyces lactis mRNA-processing endoribonuclease XP_455994.1 1892426 R 28985 CDS KLLA0_F20383g 2895002 complement(1894577..1894780) F 1 NC_006042.1 highly similar to uniprot|P02380 Saccharomyces cerevisiae YOR167C RPS28A and highly similar to uniprot|P02380 Saccharomyces cerevisiae YLR264W RPS28B Protein component of the small (40S) ribosomal subunit; 40S ribosomal protein eS28 1894780 2895002 KLLA0_F20383g Kluyveromyces lactis 40S ribosomal protein eS28 XP_455995.1 1894577 R 28985 CDS KLLA0_F20405g 2895478 complement(join(1895179..1897473,1897564..1897830)) F 1 NC_006042.1 uniprot|Q9MEM7 Kluyveromyces lactis RED1 protein; uncharacterized protein 1897830 2895478 KLLA0_F20405g Kluyveromyces lactis uncharacterized protein XP_455996.2 1895179 R 28985 CDS KLLA0_F20449g 2895480 1898253..1900667 F 1 NC_006042.1 highly similar to uniprot|P13188 Saccharomyces cerevisiae YOR168W GLN4 Glutamine tRNA synthetase monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu) N-terminal domain proposed to be involved in enzyme-tRNA interactions; glutamine--tRNA ligase 1900667 2895480 KLLA0_F20449g Kluyveromyces lactis glutamine--tRNA ligase XP_455998.1 1898253 D 28985 CDS KLLA0_F20460g 9487314 1900998..1901189 F 1 NC_006042.1 highly similar to uniprot|Q3E764 Saccharomyces cerevisiae YLR262C-A RBF7 Similar to C. elegans protein; uncharacterized protein 1901189 9487314 KLLA0_F20460g Kluyveromyces lactis uncharacterized protein XP_002999436.1 1900998 D 28985 CDS KLLA0_F20471g 2895481 1901749..1902387 F 1 NC_006042.1 highly similar to uniprot|Q99260 Saccharomyces cerevisiae YLR262C YPT6 Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi; has similarity to the human GTPase, Rab6; Rab family GTPase YPT6 1902387 2895481 KLLA0_F20471g Kluyveromyces lactis Rab family GTPase YPT6 XP_455999.1 1901749 D 28985 CDS KLLA0_F20504g 2895483 complement(1902726..1904429) F 1 NC_006042.1 similar to uniprot|Q12246 Saccharomyces cerevisiae YLR260W LCB5 Minor sphingoid long-chain base kinase paralog of Lcb4p responsible for few percent of the total activity possibly involved in synthesis of long-chain base phosphates which function as signaling molecules and similar to YOR171c; sphinganine kinase LCB4 1904429 2895483 KLLA0_F20504g Kluyveromyces lactis sphinganine kinase LCB4 XP_456001.1 1902726 R 28985 CDS KLLA0_F20526g 2895484 1905477..1906721 F 1 NC_006042.1 weakly similar to uniprot|P39927 Saccharomyces cerevisiae YGR156W PTI1 Pta1p Interacting protein; cleavage polyadenylation factor subunit PTI1 1906721 2895484 KLLA0_F20526g Kluyveromyces lactis cleavage polyadenylation factor subunit PTI1 XP_456002.1 1905477 D 28985 CDS KLLA0_F20548g 2895485 1907637..1909055 F 1 NC_006042.1 highly similar to uniprot|P17649 Saccharomyces cerevisiae YGR019W UGA1 Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways required for normal oxidative stress tolerance and nitrogen utilization; 4-aminobutyrate transaminase 1909055 2895485 KLLA0_F20548g Kluyveromyces lactis 4-aminobutyrate transaminase XP_456003.1 1907637 D 28985 CDS KLLA0_F20570g 2895463 1909451..1909990 F 1 NC_006042.1 similar to uniprot|P40081 Saccharomyces cerevisiae YER134C Hypothetical ORF; Mg-dependent acid phosphatase 1909990 2895463 KLLA0_F20570g Kluyveromyces lactis Mg-dependent acid phosphatase XP_456004.1 1909451 D 28985 CDS KLLA0_F20603g 9487453 1910783..1910962 F 1 NC_006042.1 no similarity; uncharacterized protein 1910962 9487453 KLLA0_F20603g Kluyveromyces lactis uncharacterized protein XP_002999437.1 1910783 D 28985 CDS KLLA0_F20614g 2895465 1913174..1913569 F 1 NC_006042.1 no similarity; uncharacterized protein 1913569 2895465 KLLA0_F20614g Kluyveromyces lactis uncharacterized protein XP_456005.1 1913174 D 28985 CDS KLLA0_F20636g 2895466 complement(1914452..1915309) F 1 NC_006042.1 some similarities with uniprot|Q12531 Saccharomyces cerevisiae YPR015c; uncharacterized protein 1915309 2895466 KLLA0_F20636g Kluyveromyces lactis uncharacterized protein XP_456006.1 1914452 R 28985 CDS KLLA0_F20658g 2895467 1919851..1923099 F 1 NC_006042.1 similar to uniprot|Q12691 Saccharomyces cerevisiae YDR038C ENA5 Protein with similarity to P-type ATPase sodium pumps; uncharacterized protein 1923099 2895467 KLLA0_F20658g Kluyveromyces lactis uncharacterized protein XP_456007.1 1919851 D 28985 CDS KLLA0_F20680g 2895468 1924148..1926511 F 1 NC_006042.1 weakly similar to uniprot|P39001 Saccharomyces cerevisiae YDR207C UME6 Regulator of both repression and induction of early meiotic genes. Ume6p requires Ume4 for mitotic repression and interacts with and requires Ime1p and Rim11p for induction of meiosis-specific transcription Ume6p is a C6 zinc finger URS1-binding protein.; DNA-binding transcriptional regulator UME6 1926511 2895468 KLLA0_F20680g Kluyveromyces lactis DNA-binding transcriptional regulator UME6 XP_456008.1 1924148 D 28985 CDS KLLA0_F20702g 2895469 complement(1927059..1929767) F 1 NC_006042.1 uniprot|Q9C403 Kluyveromyces lactis Putative EBS1-like protein; uncharacterized protein 1929767 2895469 KLLA0_F20702g Kluyveromyces lactis uncharacterized protein XP_456009.1 1927059 R 28985 CDS KLLA0_F20724g 2895470 1931937..1933916 F 1 NC_006042.1 similar to uniprot|P13099 Saccharomyces cerevisiae YLR234W TOP3 DNA Topoisomerase III; DNA topoisomerase 3 1933916 2895470 KLLA0_F20724g Kluyveromyces lactis DNA topoisomerase 3 XP_456010.1 1931937 D 28985 CDS KLLA0_F20746g 2895471 complement(1934089..1936200) F 1 NC_006042.1 weakly similar to uniprot|Q03455 Saccharomyces cerevisiae YDR205W MSC2 Member of the cation diffusion facilitator family localizes to the endoplasmic reticulum and nucleus mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids; metal cation transporter MSC2 1936200 2895471 KLLA0_F20746g Kluyveromyces lactis metal cation transporter MSC2 XP_456011.1 1934089 R 28985 CDS KLLA0_F20768g 2895449 complement(1936804..1937520) F 1 NC_006042.1 similar to uniprot|P40165 Saccharomyces cerevisiae YNL200C; NADHX epimerase 1937520 2895449 KLLA0_F20768g Kluyveromyces lactis NADHX epimerase XP_456012.1 1936804 R 28985 CDS KLLA0_F20790g 2895450 complement(1937781..1938836) F 1 NC_006042.1 uniprot|Q7Z8J4 Kluyveromyces lactis KLLA0F20790g gcr2 protein; uncharacterized protein 1938836 2895450 KLLA0_F20790g Kluyveromyces lactis uncharacterized protein XP_456013.1 1937781 R 28985 CDS KLLA0_F20812g 2895451 1939689..1941344 F 1 NC_006042.1 similar to uniprot|Q07657 Saccharomyces cerevisiae YDL225W SHS1 Component of the septin ring of the mother-bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM; septin SHS1 1941344 2895451 KLLA0_F20812g Kluyveromyces lactis septin SHS1 XP_456014.1 1939689 D 28985 CDS KLLA0_F20834g 2895452 complement(1942016..1943866) F 1 NC_006042.1 some similarities with Saccharomyces cerevisiae YDL224C WHI4 and to uniprot|P34761 Saccharomyces cerevisiae YNL197C WHI3; uncharacterized protein 1943866 2895452 KLLA0_F20834g Kluyveromyces lactis uncharacterized protein XP_456015.1 1942016 R 28985 CDS KLLA0_F20856g 2895453 complement(1946043..1946801) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 1946801 2895453 KLLA0_F20856g Kluyveromyces lactis uncharacterized protein XP_456016.1 1946043 R 28985 CDS KLLA0_F20878g 2895454 complement(1947379..1948821) F 1 NC_006042.1 no similarity; uncharacterized protein 1948821 2895454 KLLA0_F20878g Kluyveromyces lactis uncharacterized protein XP_456017.1 1947379 R 28985 CDS KLLA0_F20900g 2895455 complement(1949668..1950480) F 1 NC_006042.1 some similarities with uniprot|Q07651 Saccharomyces cerevisiae YDL222C FMP45 The authentic non-tagged protein was localized to the mitochondria cell cortex protein not required for growth on nonfermentable carbon sources required for viability in stationary phase; uncharacterized protein 1950480 2895455 KLLA0_F20900g Kluyveromyces lactis uncharacterized protein XP_456018.1 1949668 R 28985 CDS KLLA0_F20922g 2895456 complement(1951787..1954510) F 1 NC_006042.1 weakly similar to uniprot|P32797 Saccharomyces cerevisiae YDL220C CDC13 Single stranded DNA-binding protein found at TG1-3 telomere G-tails regulates telomere replication through recruitment of specific sub-complexes but the essential function is telomere capping; uncharacterized protein 1954510 2895456 KLLA0_F20922g Kluyveromyces lactis uncharacterized protein XP_456019.1 1951787 R 28985 CDS KLLA0_F20944g 2895457 1954947..1956371 F 1 NC_006042.1 similar to uniprot|P53870 Saccharomyces cerevisiae YNL193W Hypothetical ORF; uncharacterized protein 1956371 2895457 KLLA0_F20944g Kluyveromyces lactis uncharacterized protein XP_456020.1 1954947 D 28985 CDS KLLA0_F20966g 2895458 1956869..1959895 F 1 NC_006042.1 similar to uniprot|P08004 Saccharomyces cerevisiae YNL192W CHS1 Chitin synthase I requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin required for repairing the chitin septum during cytokinesis transcription activated by mating factor; chitin synthase I 1959895 2895458 KLLA0_F20966g Kluyveromyces lactis chitin synthase I XP_456021.1 1956869 D 28985 CDS KLLA0_F20988g 2894950 complement(1960417..1961406) F 1 NC_006042.1 uniprot|P17819 Kluyveromyces lactis KLLA0F20988g GAP1 Glyceraldehyde-3-phosphate dehydrogenase 1; uncharacterized protein 1961406 2894950 KLLA0_F20988g Kluyveromyces lactis uncharacterized protein XP_456022.1 1960417 R 28985 CDS KLLA0_F21010g 2895056 1962951..1964003 F 1 NC_006042.1 uniprot|P20369 Kluyveromyces lactis KLLA0F21010g ADH1 Alcohol dehydrogenase 1; uncharacterized protein 1964003 2895056 KLLA0_F21010g Kluyveromyces lactis uncharacterized protein XP_456023.1 1962951 D 28985 CDS KLLA0_F21032g 2895459 1964630..1965523 F 1 NC_006042.1 similar to uniprot|P38120 Saccharomyces cerevisiae YBR146W MRPS9 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein uS9m 1965523 2895459 KLLA0_F21032g Kluyveromyces lactis mitochondrial 37S ribosomal protein uS9m XP_456024.1 1964630 D 28985 CDS KLLA0_F21054g 2895460 complement(1965623..1965940) F 1 NC_006042.1 similar to uniprot|Q3E835 Saccharomyces cerevisiae YOL086W-A Hypothetical ORF identified by homology. See FEBS Letters [2000] 487:31-36.; uncharacterized protein 1965940 2895460 KLLA0_F21054g Kluyveromyces lactis uncharacterized protein XP_456025.1 1965623 R 28985 CDS KLLA0_F21076g 2895461 1966373..1969036 F 1 NC_006042.1 weakly similar to uniprot|Q99247 Saccharomyces cerevisiae YOL087C Hypothetical ORF; uncharacterized protein 1969036 2895461 KLLA0_F21076g Kluyveromyces lactis uncharacterized protein XP_456026.1 1966373 D 28985 CDS KLLA0_F21098g 2895462 1969578..1970225 F 1 NC_006042.1 highly similar to uniprot|P20434 Saccharomyces cerevisiae YBR154C RPB5 RNA polymerase subunit ABC27 common to RNA polymerases I II and III contacts DNA and affects transactivation; DNA-directed RNA polymerase core subunit RPB5 1970225 2895462 KLLA0_F21098g Kluyveromyces lactis DNA-directed RNA polymerase core subunit RPB5 XP_456027.1 1969578 D 28985 CDS KLLA0_F21120g 2895434 complement(1970487..1971245) F 1 NC_006042.1 similar to uniprot|P33312 Saccharomyces cerevisiae YBR153W RIB7 Diaminohydroxyphoshoribosylaminopyrimidine deaminase catalyzes the second step of the riboflavin biosynthesis pathway; 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase 1971245 2895434 KLLA0_F21120g Kluyveromyces lactis 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase XP_456028.1 1970487 R 28985 CDS KLLA0_F21142g 2895435 complement(1971838..1972626) F 1 NC_006042.1 weakly similar to uniprot|P38282 Saccharomyces cerevisiae YBR152W SPP381 Suppressor of Pre-mRNA Processing mutant; U4/U6.U5-associated snRNP protein; contains a PEST proteolysis motif; U4/U6-U5 snRNP complex subunit SPP381 1972626 2895435 KLLA0_F21142g Kluyveromyces lactis U4/U6-U5 snRNP complex subunit SPP381 XP_456029.1 1971838 R 28985 CDS KLLA0_F21164g 2895436 complement(1973018..1974280) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 1974280 2895436 KLLA0_F21164g Kluyveromyces lactis uncharacterized protein XP_456030.1 1973018 R 28985 CDS KLLA0_F21208g 2895438 1975203..1980527 F 1 NC_006042.1 similar to uniprot|P42945 Saccharomyces cerevisiae YJL109C UTP10 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; snoRNA-binding rRNA-processing protein UTP10 1980527 2895438 KLLA0_F21208g Kluyveromyces lactis snoRNA-binding rRNA-processing protein UTP10 XP_456032.1 1975203 D 28985 CDS KLLA0_F21230g 2895439 1980954..1981691 F 1 NC_006042.1 similar to uniprot|P36125 Saccharomyces cerevisiae YKR030W GMH1 Golgi membrane protein of unknown function interacts with Gea1p and Gea2p required for localization of Gea2p computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting; uncharacterized protein 1981691 2895439 KLLA0_F21230g Kluyveromyces lactis uncharacterized protein XP_456033.1 1980954 D 28985 CDS KLLA0_F21252g 2895440 complement(1981872..1983266) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 1983266 2895440 KLLA0_F21252g Kluyveromyces lactis uncharacterized protein XP_456034.1 1981872 R 28985 CDS KLLA0_F21274g 2895441 complement(1984163..1988971) F 1 NC_006042.1 similar to uniprot|P36126 Saccharomyces cerevisiae YKR031C SPO14 Phospholipase D catalyzes the hydrolysis of phosphatidylcholine producing choline and phosphatidic acid involved in Sec14p-independent secretion required for meiosis and spore formation differently regulated in secretion and meiosis; phospholipase D 1988971 2895441 KLLA0_F21274g Kluyveromyces lactis phospholipase D XP_456035.1 1984163 R 28985 CDS KLLA0_F21296g 2895442 1990998..1992512 F 1 NC_006042.1 some similarities with uniprot|P42944 Saccharomyces cerevisiae YJL110C GZF3 GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding function requires a repressive carbon source dimerizes with Dal80p and binds to Tor1p; uncharacterized protein 1992512 2895442 KLLA0_F21296g Kluyveromyces lactis uncharacterized protein XP_456036.1 1990998 D 28985 CDS KLLA0_F21318g 2895443 1992956..1993570 F 1 NC_006042.1 similar to uniprot|P69771 Saccharomyces cerevisiae YKR035W-A DID2 Class E protein of the vacuolar protein-sorting (Vps) pathway associates reversibly with the late endosome has human ortholog that may be altered in breast tumors; uncharacterized protein 1993570 2895443 KLLA0_F21318g Kluyveromyces lactis uncharacterized protein XP_456037.1 1992956 D 28985 CDS KLLA0_F21340g 2895444 complement(1993659..1995314) F 1 NC_006042.1 highly similar to uniprot|P42943 Saccharomyces cerevisiae YJL111W CCT7 Subunit of the cytosolic chaperonin Cct ring complex; chaperonin-containing T-complex subunit CCT7 1995314 2895444 KLLA0_F21340g Kluyveromyces lactis chaperonin-containing T-complex subunit CCT7 XP_456038.1 1993659 R 28985 CDS KLLA0_F21406g 2895446 complement(1996260..1998377) F 1 NC_006042.1 similar to uniprot|P47025 Saccharomyces cerevisiae YJL112W MDV1 WD repeat protein that regulates steps in the Dnm1p-dependent process of mitochondrial fission; uncharacterized protein 1998377 2895446 KLLA0_F21406g Kluyveromyces lactis uncharacterized protein XP_456039.1 1996260 R 28985 CDS KLLA0_F21428g 2895447 complement(1998804..1999631) F 1 NC_006042.1 similar to uniprot|P36131 Saccharomyces cerevisiae YKR037C SPC34 Component of Dam1p complex important for spindle and kinetochore integrity localized to nuclear side of spindle pole body and along mitotic spindle; uncharacterized protein 1999631 2895447 KLLA0_F21428g Kluyveromyces lactis uncharacterized protein XP_456040.1 1998804 R 28985 CDS KLLA0_F21450g 2895448 complement(1999977..2001134) F 1 NC_006042.1 highly similar to uniprot|P36132 Saccharomyces cerevisiae YKR038C KAE1 Putative glycoprotease that interacts with Bud32p which is a member of the novel protein kinase piD261 family; tRNA N6-adenosine threonylcarbamoyltransferase 2001134 2895448 KLLA0_F21450g Kluyveromyces lactis tRNA N6-adenosine threonylcarbamoyltransferase XP_456041.1 1999977 R 28985 CDS KLLA0_F21560g 2895427 2002551..2004077 F 1 NC_006042.1 some similarities with uniprot|P08465 Saccharomyces cerevisiae YNL277W MET2 L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway; uncharacterized protein 2004077 2895427 KLLA0_F21560g Kluyveromyces lactis uncharacterized protein XP_456042.1 2002551 D 28985 CDS KLLA0_F21582g 2895428 complement(2004309..2005157) F 1 NC_006042.1 similar to uniprot|P21771 Saccharomyces cerevisiae YDR337W MRPS28 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein uS15m 2005157 2895428 KLLA0_F21582g Kluyveromyces lactis mitochondrial 37S ribosomal protein uS15m XP_456043.1 2004309 R 28985 CDS KLLA0_F21604g 2895429 2005981..2006640 F 1 NC_006042.1 some similarities with uniprot|P28007 Saccharomyces cerevisiae YHR089C GAR1 Protein component of the H/ACA snoRNP pseudouridylase complex involved in the modification and cleavage of the 18S pre-rRNA; uncharacterized protein 2006640 2895429 KLLA0_F21604g Kluyveromyces lactis uncharacterized protein XP_456044.1 2005981 D 28985 CDS KLLA0_F21626g 2895430 complement(2006961..2008040) F 1 NC_006042.1 similar to uniprot|Q05473 Saccharomyces cerevisiae YDR336W Hypothetical ORF; uncharacterized protein 2008040 2895430 KLLA0_F21626g Kluyveromyces lactis uncharacterized protein XP_456045.1 2006961 R 28985 CDS KLLA0_F21648g 2895431 complement(2008351..2012016) F 1 NC_006042.1 highly similar to uniprot|P52918 Saccharomyces cerevisiae YDR335W MSN5 Karyopherin involved in nuclear import and export shown to be responsible for nuclear import of replication protein A and for export of several proteins including Swi6p Far1p and Pho4p cargo dissociation involves binding to RanGTP; karyopherin MSN5 2012016 2895431 KLLA0_F21648g Kluyveromyces lactis karyopherin MSN5 XP_456046.1 2008351 R 28985 CDS KLLA0_F21670g 2895432 complement(2012737..2013615) F 1 NC_006042.1 highly similar to uniprot|P38805 Saccharomyces cerevisiae YHR088W RPF1 Nucleolar protein involved in the assembly of the large ribosomal subunit contains a sigma(70)-like motif which is thought to bind RNA; rRNA-binding ribosome biosynthesis protein RPF1 2013615 2895432 KLLA0_F21670g Kluyveromyces lactis rRNA-binding ribosome biosynthesis protein RPF1 XP_456047.1 2012737 R 28985 CDS KLLA0_F21692g 2895433 complement(2014152..2018729) F 1 NC_006042.1 uniprot|Q96WM8 Kluyveromyces lactis KLLA0F21692g Pdr5 Multidrug pump KlPDR5; uncharacterized protein 2018729 2895433 KLLA0_F21692g Kluyveromyces lactis uncharacterized protein XP_456048.1 2014152 R 28985 CDS KLLA0_F21714g 2895410 2020262..2022271 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 2022271 2895410 KLLA0_F21714g Kluyveromyces lactis uncharacterized protein XP_456049.1 2020262 D 28985 CDS KLLA0_F21736g 2895411 complement(2022575..2022922) F 1 NC_006042.1 similar to uniprot|P38804 Saccharomyces cerevisiae YHR087W Hypothetical ORF; uncharacterized protein 2022922 2895411 KLLA0_F21736g Kluyveromyces lactis uncharacterized protein XP_456050.1 2022575 R 28985 CDS KLLA0_F21758g 2895412 complement(2023805..2028523) F 1 NC_006042.1 similar to uniprot|Q05471 Saccharomyces cerevisiae YDR334W SWR1 Swi2/Snf2-related ATPase; chromatin-remodeling protein SWR1 2028523 2895412 KLLA0_F21758g Kluyveromyces lactis chromatin-remodeling protein SWR1 XP_456051.1 2023805 R 28985 CDS KLLA0_F21802g 2895414 2029687..2031519 F 1 NC_006042.1 similar to uniprot|P38767 Saccharomyces cerevisiae YHR032W Hypothetical ORF; uncharacterized protein 2031519 2895414 KLLA0_F21802g Kluyveromyces lactis uncharacterized protein XP_456053.1 2029687 D 28985 CDS KLLA0_F21824g 2895415 complement(2031719..2032549) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 2032549 2895415 KLLA0_F21824g Kluyveromyces lactis uncharacterized protein XP_456054.1 2031719 R 28985 CDS KLLA0_F21846g 2895416 complement(2033135..2034265) F 1 NC_006042.1 similar to uniprot|P38779 Saccharomyces cerevisiae YHR052W CIC1 Core interacting component 1 ribosome biogenesis protein; uncharacterized protein 2034265 2895416 KLLA0_F21846g Kluyveromyces lactis uncharacterized protein XP_456055.1 2033135 R 28985 CDS KLLA0_F21868g 2895417 2035168..2035683 F 1 NC_006042.1 similar to uniprot|P36053 Saccharomyces cerevisiae YKL160W ELF1 Protein of unknown function deletion inhibits Brome mosaic virus expression; uncharacterized protein 2035683 2895417 KLLA0_F21868g Kluyveromyces lactis uncharacterized protein XP_456056.1 2035168 D 28985 CDS KLLA0_F21890g 2895418 complement(2036621..2037064) F 1 NC_006042.1 similar to uniprot|P00427 Saccharomyces cerevisiae YHR051W COX6 Subunit VI of cytochrome c oxidase which is the terminal member of the mitochondrial inner membrane electron transport chain expression is regulated by oxygen levels; cytochrome c oxidase subunit VI 2037064 2895418 KLLA0_F21890g Kluyveromyces lactis cytochrome c oxidase subunit VI XP_456057.1 2036621 R 28985 CDS KLLA0_F21934g 2895420 2039116..2039718 F 1 NC_006042.1 similar to uniprot|P47089 Saccharomyces cerevisiae YJR014W RBF22 Hypothetical ORF; uncharacterized protein 2039718 2895420 KLLA0_F21934g Kluyveromyces lactis uncharacterized protein XP_456059.1 2039116 D 28985 CDS KLLA0_F21956g 2895421 2040151..2042310 F 1 NC_006042.1 similar to uniprot|P46951 Saccharomyces cerevisiae YGR198W Essential protein of unknown function; uncharacterized protein 2042310 2895421 KLLA0_F21956g Kluyveromyces lactis uncharacterized protein XP_456060.1 2040151 D 28985 CDS KLLA0_F21978g 2895422 2042656..2044929 F 1 NC_006042.1 similar to uniprot|P42934 Saccharomyces cerevisiae YGR199W PMT6 Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase; dolichyl-phosphate-mannose-protein mannosyltransferase PMT6 2044929 2895422 KLLA0_F21978g Kluyveromyces lactis dolichyl-phosphate-mannose-protein mannosyltransferase PMT6 XP_456061.1 2042656 D 28985 CDS KLLA0_F22000g 2895423 complement(2044973..2047354) F 1 NC_006042.1 similar to uniprot|P42935 Saccharomyces cerevisiae YGR200C ELP2 Elongator protein part of the six-subunit RNA polymerase II Elongator histone acetyltransferase complex target of Kluyveromyces lactis zymocin; Elongator subunit ELP2 2047354 2895423 KLLA0_F22000g Kluyveromyces lactis Elongator subunit ELP2 XP_456062.1 2044973 R 28985 CDS KLLA0_F22022g 2895396 complement(2047835..2049586) F 1 NC_006042.1 highly similar to uniprot|P39522 Saccharomyces cerevisiae YJR016C ILV3 Dihydroxyacid dehydratase catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids; dihydroxy-acid dehydratase ILV3 2049586 2895396 KLLA0_F22022g Kluyveromyces lactis dihydroxy-acid dehydratase ILV3 XP_456063.1 2047835 R 28985 CDS KLLA0_F22066g 2895398 complement(2051033..2062327) F 1 NC_006042.1 similar to uniprot|P38811 Saccharomyces cerevisiae YHR099W TRA1 Histone acetyltransferase component putative ortholog of human TRRAP which is an essential cofactor of c-Myc; histone acetyltransferase TRA1 2062327 2895398 KLLA0_F22066g Kluyveromyces lactis histone acetyltransferase TRA1 XP_456065.1 2051033 R 28985 CDS KLLA0_F22088g 2895399 2064310..2065986 F 1 NC_006042.1 weakly similar to uniprot|Q66RD4 Saccharomyces cerevisiae YDR349C YPS7 Putative GPI-anchored aspartic protease located in the cytoplasm and endoplasmic reticulum; uncharacterized protein 2065986 2895399 KLLA0_F22088g Kluyveromyces lactis uncharacterized protein XP_456066.1 2064310 D 28985 CDS KLLA0_F22110g 2895400 2066619..2069372 F 1 NC_006042.1 similar to uniprot|P38810 Saccharomyces cerevisiae YHR098C SFB3 Member of the Sec24p family forms a complex with Sec23p that is involved in sorting of Pma1p into COPII vesicles peripheral ER membrane protein potential Cdc28p substrate; uncharacterized protein 2069372 2895400 KLLA0_F22110g Kluyveromyces lactis uncharacterized protein XP_456067.1 2066619 D 28985 CDS KLLA0_F22154g 2895402 join(2069922..2070232,2071226..2072507) F 1 NC_006042.1 similar to uniprot|Q66RD5 Saccharomyces cerevisiae YDR348C Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud neck; potential Cdc28p substrate; uncharacterized protein 2072507 2895402 KLLA0_F22154g Kluyveromyces lactis uncharacterized protein XP_456069.2 2069922 D 28985 CDS KLLA0_F22176g 2895403 complement(2073042..2073926) F 1 NC_006042.1 similar to uniprot|P10662 Saccharomyces cerevisiae YDR347W MRP1 Mitochondrial ribosomal protein of the small subunit MRP1 exhibits genetic interactions with PET122 encoding a COX3-specific translational activator and with PET123 encoding a small subunit mitochondrial ribosomal protein; mitochondrial 37S ribosomal protein mS43 2073926 2895403 KLLA0_F22176g Kluyveromyces lactis mitochondrial 37S ribosomal protein mS43 XP_456070.1 2073042 R 28985 CDS KLLA0_F22198g 2895404 2075028..2077334 F 1 NC_006042.1 similar to gnl|GLV|DEHA0F25982g Debaryomyces hansenii DEHA0F25982g; uncharacterized protein 2077334 2895404 KLLA0_F22198g Kluyveromyces lactis uncharacterized protein XP_456071.2 2075028 D 28985 CDS KLLA0_F22220g 2895405 complement(2077500..2078861) F 1 NC_006042.1 similar to uniprot|P31755 Saccharomyces cerevisiae YGL038C OCH1 Mannosyltransferase of the cis-Golgi apparatus initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins; initiation-specific alpha-1,6-mannosyltransferase 2078861 2895405 KLLA0_F22220g Kluyveromyces lactis initiation-specific alpha-1,6-mannosyltransferase XP_456072.1 2077500 R 28985 CDS KLLA0_F22242g 2895406 complement(2079462..2080118) F 1 NC_006042.1 similar to uniprot|P53184 Saccharomyces cerevisiae YGL037C PNC1 NAD() salvage pathway gene pyrazinamidase and nicotinamidase; nicotinamidase 2080118 2895406 KLLA0_F22242g Kluyveromyces lactis nicotinamidase XP_456073.1 2079462 R 28985 CDS KLLA0_F22275g 2895408 2080657..2082984 F 1 NC_006042.1 weakly similar to uniprot|P53185 Saccharomyces cerevisiae YGL036W Mtf1 Two Hybrid Clone 2; uncharacterized protein 2082984 2895408 KLLA0_F22275g Kluyveromyces lactis uncharacterized protein XP_456075.1 2080657 D 28985 CDS KLLA0_F22297g 2895409 complement(2083448..2085547) F 1 NC_006042.1 similar to uniprot|P32350 Saccharomyces cerevisiae YLL019C KNS1 Nonessential putative protein kinase of unknown cellular role member of the LAMMER family of protein kinases which are serine/threonine kinases also capable of phosphorylating tyrosine residues; serine/threonine protein kinase KNS1 2085547 2895409 KLLA0_F22297g Kluyveromyces lactis serine/threonine protein kinase KNS1 XP_456076.1 2083448 R 28985 CDS KLLA0_F22319g 2895387 complement(2086613..2087224) F 1 NC_006042.1 some similarities with uniprot|Q6Q5F4 Saccharomyces cerevisiae YPR015C Hypothetical ORF; uncharacterized protein 2087224 2895387 KLLA0_F22319g Kluyveromyces lactis uncharacterized protein XP_456077.1 2086613 R 28985 CDS KLLA0_F22341g 2895388 complement(2088007..2088966) F 1 NC_006042.1 no similarity; uncharacterized protein 2088966 2895388 KLLA0_F22341g Kluyveromyces lactis uncharacterized protein XP_456078.1 2088007 R 28985 CDS KLLA0_F22363g 2895389 complement(2089476..2090693) F 1 NC_006042.1 some similarities with uniprot|Q02199 Saccharomyces cerevisiae YGL172W NUP49 Subunit of the Nsp1p-Nup57p-Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC) required for nuclear export of ribosomes; FG-nucleoporin NUP49 2090693 2895389 KLLA0_F22363g Kluyveromyces lactis FG-nucleoporin NUP49 XP_456079.1 2089476 R 28985 CDS KLLA0_F22385g 2895390 2091235..2095596 F 1 NC_006042.1 similar to uniprot|P22147 Saccharomyces cerevisiae YGL173C KEM1 5'-3' exonuclease involved in mRNA decay evolutionarily conserved component of cytoplasmic processing (P) bodies plays a role in microtubule-mediated processes filamentous growth and ribosomal RNA maturation; chromatin-binding exonuclease XRN1 2095596 2895390 KLLA0_F22385g Kluyveromyces lactis chromatin-binding exonuclease XRN1 XP_456080.1 2091235 D 28985 CDS KLLA0_F22407g 2895391 complement(2095693..2096499) F 1 NC_006042.1 weakly similar to uniprot|P46947 Saccharomyces cerevisiae YGL174W BUD13 Protein involved in bud-site selection diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern; uncharacterized protein 2096499 2895391 KLLA0_F22407g Kluyveromyces lactis uncharacterized protein XP_456081.1 2095693 R 28985 CDS KLLA0_F22429g 2895392 2096803..2097852 F 1 NC_006042.1 weakly similar to uniprot|P46946 Saccharomyces cerevisiae YGL175C SAE2 Protein with a role in accurate meiotic and mitotic double-strand break repair phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents; ssDNA endodeoxyribonuclease SAE2 2097852 2895392 KLLA0_F22429g Kluyveromyces lactis ssDNA endodeoxyribonuclease SAE2 XP_456082.1 2096803 D 28985 CDS KLLA0_F22451g 2895393 2098204..2099559 F 1 NC_006042.1 similar to uniprot|P33895 Saccharomyces cerevisiae YOL069W NUF2 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p) involved in chromosome segregation spindle checkpoint activity and kinetochore clustering; kinetochore-associated Ndc80 complex subunit NUF2 2099559 2895393 KLLA0_F22451g Kluyveromyces lactis kinetochore-associated Ndc80 complex subunit NUF2 XP_456083.1 2098204 D 28985 CDS KLLA0_F22473g 2895394 complement(2099623..2100384) F 1 NC_006042.1 similar to uniprot|Q07350 Saccharomyces cerevisiae YDL043C PRP11 Subunit of the SF3a splicing factor complex required for spliceosome assembly; uncharacterized protein 2100384 2895394 KLLA0_F22473g Kluyveromyces lactis uncharacterized protein XP_456084.1 2099623 R 28985 CDS KLLA0_F22495g 2895395 complement(join(2100746..2101186,2101529..2102089)) F 1 NC_006042.1 similar to uniprot|P53292 Saccharomyces cerevisiae YGR165W MRPS35 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein mS45 2102089 2895395 KLLA0_F22495g Kluyveromyces lactis mitochondrial 37S ribosomal protein mS45 XP_456085.2 2100746 R 28985 CDS KLLA0_F22539g 2895372 2102745..2104670 F 1 NC_006042.1 some similarities with uniprot|P47069 Saccharomyces cerevisiae YJL019W MPS3 Essential integral membrane protein required for spindle pole body duplication and for nuclear fusion localizes to the spindle pole body half bridge interacts with DnaJ-like chaperone Jem1p and with centrin homolog Cdc31p; uncharacterized protein 2104670 2895372 KLLA0_F22539g Kluyveromyces lactis uncharacterized protein XP_456087.1 2102745 D 28985 CDS KLLA0_F22561g 2895373 2105219..2106844 F 1 NC_006042.1 weakly similar to uniprot|P47071 Saccharomyces cerevisiae YJL016W; uncharacterized protein 2106844 2895373 KLLA0_F22561g Kluyveromyces lactis uncharacterized protein XP_456088.1 2105219 D 28985 CDS KLLA0_F22583g 2895374 2107305..2108909 F 1 NC_006042.1 highly similar to uniprot|P39077 Saccharomyces cerevisiae YJL014W CCT3 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo; chaperonin-containing T-complex subunit CCT3 2108909 2895374 KLLA0_F22583g Kluyveromyces lactis chaperonin-containing T-complex subunit CCT3 XP_456089.1 2107305 D 28985 CDS KLLA0_F22605g 2895375 complement(2109034..2111913) F 1 NC_006042.1 similar to uniprot|P41695 Saccharomyces cerevisiae YGR188C BUB1 Protein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage associates with centromere DNA via Skp1p; uncharacterized protein 2111913 2895375 KLLA0_F22605g Kluyveromyces lactis uncharacterized protein XP_456090.1 2109034 R 28985 CDS KLLA0_F22627g 2895376 complement(2112336..2114525) F 1 NC_006042.1 highly similar to uniprot|P47075 Saccharomyces cerevisiae YJL012C VTC4 Phosphate metabolism transcription is regulated by PHO system polyphosphate synthetase (putative); uncharacterized protein 2114525 2895376 KLLA0_F22627g Kluyveromyces lactis uncharacterized protein XP_456091.1 2112336 R 28985 CDS KLLA0_F22649g 2895377 complement(2114753..2115220) F 1 NC_006042.1 similar to uniprot|P47076 Saccharomyces cerevisiae YJL011C RPC17 RNA polymerase III subunit C17 physically interacts with C31 C11 and TFIIIB70 may be involved in the recruitment of pol III by the preinitiation complex; DNA-directed RNA polymerase III subunit RPC17 2115220 2895377 KLLA0_F22649g Kluyveromyces lactis DNA-directed RNA polymerase III subunit RPC17 XP_456092.1 2114753 R 28985 CDS KLLA0_F22671g 2895378 complement(2115530..2116930) F 1 NC_006042.1 similar to uniprot|P53301 Saccharomyces cerevisiae YGR189C CRH1 Putative glycosidase of the cell wall may have a role in cell wall architecture; transglycosylase 2116930 2895378 KLLA0_F22671g Kluyveromyces lactis transglycosylase XP_456093.1 2115530 R 28985 CDS KLLA0_F22792g 2895383 2118783..2119145 F 1 NC_006042.1 some similarities with uniprot|Q04814 Saccharomyces cerevisiae YMR252C Hypothetical ORF; uncharacterized protein 2119145 2895383 KLLA0_F22792g Kluyveromyces lactis uncharacterized protein XP_456095.1 2118783 D 28985 CDS KLLA0_F22814g 2895385 complement(2119266..2119736) F 1 NC_006042.1 highly similar to uniprot|P35181 Saccharomyces cerevisiae YLR170C APS1 Small subunit of the clathrin-associated adaptor complex AP-1 which is involved in protein sorting at the trans-Golgi network homolog of the sigma subunit of the mammalian clathrin AP-1 complex; uncharacterized protein 2119736 2895385 KLLA0_F22814g Kluyveromyces lactis uncharacterized protein XP_456097.1 2119266 R 28985 CDS KLLA0_F22836g 2895356 complement(2120129..2121025) F 1 NC_006042.1 highly similar to uniprot|P32469 Saccharomyces cerevisiae YLR172C DPH5 Methyltransferase required for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) not essential for viability GFP-Dph5p fusion protein localizes to the cytoplasm; diphthine synthase 2121025 2895356 KLLA0_F22836g Kluyveromyces lactis diphthine synthase XP_456098.1 2120129 R 28985 CDS KLLA0_F22858g 2895357 2121352..2123118 F 1 NC_006042.1 weakly similar to uniprot|Q06247 Saccharomyces cerevisiae YLR173W Hypothetical ORF; uncharacterized protein 2123118 2895357 KLLA0_F22858g Kluyveromyces lactis uncharacterized protein XP_456099.1 2121352 D 28985 CDS KLLA0_F22880g 2895358 2123577..2127071 F 1 NC_006042.1 some similarities with uniprot|P12351 Saccharomyces cerevisiae YLR256W HAP1; uncharacterized protein 2127071 2895358 KLLA0_F22880g Kluyveromyces lactis uncharacterized protein XP_456100.1 2123577 D 28985 CDS KLLA0_F22902g 2895359 complement(2127147..2128682) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 2128682 2895359 KLLA0_F22902g Kluyveromyces lactis uncharacterized protein XP_456101.1 2127147 R 28985 CDS KLLA0_F22924g 2895360 2129434..2130021 F 1 NC_006042.1 similar to uniprot|Q06563 Saccharomyces cerevisiae YLR251W SYM1 Protein homologous to mammalian peroxisomal membrane protein Mpv17 required for ethanol metabolismand induced by heat shock localized to the inner mitochondrial membrane; ethanol metabolism protein 2130021 2895360 KLLA0_F22924g Kluyveromyces lactis ethanol metabolism protein XP_456102.1 2129434 D 28985 CDS KLLA0_F22946g 2895361 2130327..2132018 F 1 NC_006042.1 similar to uniprot|Q06567 Saccharomyces cerevisiae YLR253W Hypothetical ORF; uncharacterized protein 2132018 2895361 KLLA0_F22946g Kluyveromyces lactis uncharacterized protein XP_456103.1 2130327 D 28985 CDS KLLA0_F22968g 2895362 complement(2132132..2133136) F 1 NC_006042.1 similar to uniprot|P53110 Saccharomyces cerevisiae YGL159W Hypothetical ORF; uncharacterized protein 2133136 2895362 KLLA0_F22968g Kluyveromyces lactis uncharacterized protein XP_456104.1 2132132 R 28985 CDS KLLA0_F22990g 2895363 2134385..2138146 F 1 NC_006042.1 uniprot|Q6DR96 Kluyveromyces lactis HAP1; uncharacterized protein 2138146 2895363 KLLA0_F22990g Kluyveromyces lactis uncharacterized protein XP_456105.1 2134385 D 28985 CDS KLLA0_F23012g 2895364 2138821..2140566 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 2140566 2895364 KLLA0_F23012g Kluyveromyces lactis uncharacterized protein XP_456106.1 2138821 D 28985 CDS KLLA0_F23034g 2895365 complement(2140638..2142164) F 1 NC_006042.1 weakly similar to uniprot|P53109 Saccharomyces cerevisiae YGL160W Hypothetical ORF; uncharacterized protein 2142164 2895365 KLLA0_F23034g Kluyveromyces lactis uncharacterized protein XP_456107.1 2140638 R 28985 CDS KLLA0_F23078g 2895367 2143618..2144517 F 1 NC_006042.1 similar to uniprot|Q06146 Saccharomyces cerevisiae YLR257W Hypothetical ORF; uncharacterized protein 2144517 2895367 KLLA0_F23078g Kluyveromyces lactis uncharacterized protein XP_456108.1 2143618 D 28985 CDS KLLA0_F23089g 2895368 2145083..2146084 F 1 NC_006042.1 some similarities with uniprot|P43597 Saccharomyces cerevisiae YFR016C Hypothetical ORF; uncharacterized protein 2146084 2895368 KLLA0_F23089g Kluyveromyces lactis uncharacterized protein XP_456109.1 2145083 D 28985 CDS KLLA0_F23111g 2895369 2151398..2153464 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 2153464 2895369 KLLA0_F23111g Kluyveromyces lactis uncharacterized protein XP_456110.1 2151398 D 28985 CDS KLLA0_F23133g 2895370 2154515..2156623 F 1 NC_006042.1 highly similar to uniprot|P23337 Saccharomyces cerevisiae or YLR258W uniprot|P27472 Saccharomyces cerevisiae; uncharacterized protein 2156623 2895370 KLLA0_F23133g Kluyveromyces lactis uncharacterized protein XP_456111.1 2154515 D 28985 CDS KLLA0_F23155g 2895347 2157146..2158429 F 1 NC_006042.1 similar to uniprot|P22517 Saccharomyces cerevisiae YOL016C CMK2 Calmodulin-dependent protein kinase and uniprot|P27466 Saccharomyces cerevisiae YFR014C CMK1; uncharacterized protein 2158429 2895347 KLLA0_F23155g Kluyveromyces lactis uncharacterized protein XP_456112.1 2157146 D 28985 CDS KLLA0_F23199g 2895349 complement(2159245..2162067) F 1 NC_006042.1 some similarities with uniprot|P43596 Saccharomyces cerevisiae YFR013W IOC3 Member of a complex (Isw1a) with Isw1p that has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome has homology to Esc8p which is involved in silencing; uncharacterized protein 2162067 2895349 KLLA0_F23199g Kluyveromyces lactis uncharacterized protein XP_456113.1 2159245 R 28985 CDS KLLA0_F23221g 2895350 2163234..2164850 F 1 NC_006042.1 some similarities with uniprot|O13581 Saccharomyces cerevisiae YDL128W VCX1 Vacuolar H+/Ca2+ exchanger, has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter; uncharacterized protein 2164850 2895350 KLLA0_F23221g Kluyveromyces lactis uncharacterized protein XP_456114.1 2163234 D 28985 CDS KLLA0_F23243g 2895351 2165407..2170368 F 1 NC_006042.1 highly similar to uniprot|P10964 Saccharomyces cerevisiae YOR341W RPA190 RNA polymerase I subunit largest subunit of RNA polymerase I; DNA-directed RNA polymerase I core subunit RPA190 2170368 2895351 KLLA0_F23243g Kluyveromyces lactis DNA-directed RNA polymerase I core subunit RPA190 XP_456115.1 2165407 D 28985 CDS KLLA0_F23265g 2895352 complement(2170525..2173428) F 1 NC_006042.1 similar to uniprot|P39730 Saccharomyces cerevisiae YAL035W FUN12 GTPase required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining homolog of bacterial IF2; translation initiation factor eIF5B 2173428 2895352 KLLA0_F23265g Kluyveromyces lactis translation initiation factor eIF5B XP_456116.1 2170525 R 28985 CDS KLLA0_F23287g 2895353 2174090..2175199 F 1 NC_006042.1 highly similar to uniprot|P39729 Saccharomyces cerevisiae YAL036C RBG1 GTPase that interacts with ribosomes member of the DRG family of GTP-binding proteins; GTP-binding protein RBG1 2175199 2895353 KLLA0_F23287g Kluyveromyces lactis GTP-binding protein RBG1 XP_456117.1 2174090 D 28985 CDS KLLA0_F23309g 2895354 complement(2175773..2176759) F 1 NC_006042.1 similar to uniprot|Q12182 Saccharomyces cerevisiae YOR342C Hypothetical ORF; uncharacterized protein 2176759 2895354 KLLA0_F23309g Kluyveromyces lactis uncharacterized protein XP_456118.1 2175773 R 28985 CDS KLLA0_F23331g 2895355 2177477..2178658 F 1 NC_006042.1 no similarity; uncharacterized protein 2178658 2895355 KLLA0_F23331g Kluyveromyces lactis uncharacterized protein XP_456119.1 2177477 D 28985 CDS KLLA0_F23353g 2895320 complement(2178959..2179804) F 1 NC_006042.1 uniprot|Q92242 Kluyveromyces lactis SCK1 Multicopy supressor of caseine kinase 1 mutation and weakly similar to uniprot|P33122 Saccharomyces cerevisiae YOR344C TYE7 may be involved in glycolytic gene expression TYE7 a 33 kDa serine-rich protein is a potential member of the basic region/helix-loop-helix/leucine-zipper protein family; uncharacterized protein 2179804 2895320 KLLA0_F23353g Kluyveromyces lactis uncharacterized protein XP_456120.1 2178959 R 28985 CDS KLLA0_F23375g 2895321 2181986..2184475 F 1 NC_006042.1 similar to uniprot|P12689 Saccharomyces cerevisiae YOR346W REV1 Deoxycytidyl transferase forms a complex with the subunits of DNA polymerase zeta Rev3p and Rev7p involved in repair of abasic sites in damaged DNA; deoxycytidyl transferase 2184475 2895321 KLLA0_F23375g Kluyveromyces lactis deoxycytidyl transferase XP_456121.1 2181986 D 28985 CDS KLLA0_F23397g 2895322 complement(2184751..2186256) F 1 NC_006042.1 uniprot|Q875M9 Kluyveromyces lactis KLLA0F23397g PYK1 Pyruvate kinase; pyruvate kinase PYK2 2186256 2895322 KLLA0_F23397g Kluyveromyces lactis pyruvate kinase PYK2 XP_456122.1 2184751 R 28985 CDS KLLA0_F23419g 2895323 complement(2187386..2189107) F 1 NC_006042.1 similar to uniprot|P15380 Saccharomyces cerevisiae YOR348C PUT4 proline-specific permease (also capable of transporting alanine and glycine) putative proline-specific permease; proline permease PUT4 2189107 2895323 KLLA0_F23419g Kluyveromyces lactis proline permease PUT4 XP_456123.1 2187386 R 28985 CDS KLLA0_F23441g 2895324 2191499..2192845 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 2192845 2895324 KLLA0_F23441g Kluyveromyces lactis uncharacterized protein XP_456124.1 2191499 D 28985 CDS KLLA0_F23463g 2895325 2193239..2196280 F 1 NC_006042.1 weakly similar to uniprot|P40987 Saccharomyces cerevisiae YOR349W CIN1 Tubulin folding factor D involved in beta-tubulin (Tub2p) folding isolated as mutant with increased chromosome loss and sensitivity to benomyl; uncharacterized protein 2196280 2895325 KLLA0_F23463g Kluyveromyces lactis uncharacterized protein XP_456125.1 2193239 D 28985 CDS KLLA0_F23485g 2895326 complement(2196285..2198192) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 2198192 2895326 KLLA0_F23485g Kluyveromyces lactis uncharacterized protein XP_456126.1 2196285 R 28985 CDS KLLA0_F23507g 2895327 complement(2198603..2200066) F 1 NC_006042.1 similar to uniprot|P24719 Saccharomyces cerevisiae YOR351C MEK1 Meiosis-specific serine/threonine protein kinase functions in meiotic checkpoint; serine/threonine protein kinase MEK1 2200066 2895327 KLLA0_F23507g Kluyveromyces lactis serine/threonine protein kinase MEK1 XP_456127.1 2198603 R 28985 CDS KLLA0_F23529g 2895328 2200946..2202775 F 1 NC_006042.1 highly similar to uniprot|P06208 Saccharomyces cerevisiae YNL104C LEU4 Alpha-isopropylmalate synthase (2-isopropylmalate synthase) the main isozyme responsible for the first step in the leucine biosynthesis pathway; uncharacterized protein 2202775 2895328 KLLA0_F23529g Kluyveromyces lactis uncharacterized protein XP_456128.1 2200946 D 28985 CDS KLLA0_F23551g 2895329 2203276..2206557 F 1 NC_006042.1 similar to uniprot|Q12271 YOR109w Saccharomyces cerevisiae INP53 Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; uncharacterized protein 2206557 2895329 KLLA0_F23551g Kluyveromyces lactis uncharacterized protein XP_456129.1 2203276 D 28985 CDS KLLA0_F23573g 2895330 2206864..2207460 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 2207460 2895330 KLLA0_F23573g Kluyveromyces lactis uncharacterized protein XP_456130.1 2206864 D 28985 CDS KLLA0_F23584g 2895331 complement(2207441..2208103) F 1 NC_006042.1 similar to uniprot|P53930 Saccharomyces cerevisiae YNL107W YAF9 Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex may function to antagonize silencing near telomeres interacts directly with Swc4p has homology to human leukemogenic protein AF9 contains a YEATS domain; YEATS domain-containing protein YAF9 2208103 2895331 KLLA0_F23584g Kluyveromyces lactis YEATS domain-containing protein YAF9 XP_456131.1 2207441 R 28985 CDS KLLA0_F23606g 2895332 2208465..2209637 F 1 NC_006042.1 similar to uniprot|Q6B220 Saccharomyces cerevisiae YOR110W; uncharacterized protein 2209637 2895332 KLLA0_F23606g Kluyveromyces lactis uncharacterized protein XP_456132.1 2208465 D 28985 CDS KLLA0_F23628g 2895333 2209790..2210431 F 1 NC_006042.1 similar to uniprot|Q99210 Saccharomyces cerevisiae YOR111W Hypothetical ORF; nucleotide diphosphatase 2210431 2895333 KLLA0_F23628g Kluyveromyces lactis nucleotide diphosphatase XP_456133.1 2209790 D 28985 CDS KLLA0_F23650g 2895288 2210563..2211501 F 1 NC_006042.1 similar to uniprot|P53927 Saccharomyces cerevisiae YNL110C NOP15 Constituent of 66S pre-ribosomal particles involved in 60S ribosomal subunit biogenesis localizes to both nucleolus and cytoplasm; rRNA-binding ribosome biosynthesis protein NOP15 2211501 2895288 KLLA0_F23650g Kluyveromyces lactis rRNA-binding ribosome biosynthesis protein NOP15 XP_456134.1 2210563 D 28985 CDS KLLA0_F23672g 2895289 2212223..2212594 F 1 NC_006042.1 similar to uniprot|P40312 Saccharomyces cerevisiae YNL111C CYB5 Cytochrome b5 involved in the sterol and lipid biosynthesis pathways required for sterol C5-6 and fatty acid desaturation; uncharacterized protein 2212594 2895289 KLLA0_F23672g Kluyveromyces lactis uncharacterized protein XP_456135.1 2212223 D 28985 CDS KLLA0_F23694g 2895290 2213137..2215302 F 1 NC_006042.1 similar to uniprot|Q12453 Saccharomyces cerevisiae YOR112W Hypothetical ORF; uncharacterized protein 2215302 2895290 KLLA0_F23694g Kluyveromyces lactis uncharacterized protein XP_456136.1 2213137 D 28985 CDS KLLA0_F23716g 2895291 complement(join(2215454..2215845,2216857..2218129)) F 1 NC_006042.1 similar to uniprot|P24783 Saccharomyces cerevisiae YNL112W DBP2 Essential ATP-dependent RNA helicase of the DEAD-box protein family involved in nonsense-mediated mRNA decay and rRNA processing; DEAD-box ATP-dependent RNA helicase DBP2 2218129 2895291 KLLA0_F23716g Kluyveromyces lactis DEAD-box ATP-dependent RNA helicase DBP2 XP_456137.1 2215454 R 28985 CDS KLLA0_F23760g 2895292 complement(2218555..2218938) F 1 NC_006042.1 similar to uniprot|P28000 Saccharomyces cerevisiae YNL113W RPC19 RNA polymerase subunit common to RNA polymerases I and III; DNA-directed RNA polymerase core subunit RPC19 2218938 2895292 KLLA0_F23760g Kluyveromyces lactis DNA-directed RNA polymerase core subunit RPC19 XP_456138.1 2218555 R 28985 CDS KLLA0_F23782g 2895293 2219920..2222268 F 1 NC_006042.1 weakly similar to uniprot|P41696 Saccharomyces cerevisiae YOR113W AZF1 Zinc-finger transcription factor involved in induction of CLN3 transcription in response to glucose genetic and physical interactions indicate a possible role in mitochondrial transcription or genome maintenance; uncharacterized protein 2222268 2895293 KLLA0_F23782g Kluyveromyces lactis uncharacterized protein XP_456139.1 2219920 D 28985 CDS KLLA0_F23804g 2895294 2222945..2223757 F 1 NC_006042.1 similar to uniprot|Q12219 Saccharomyces cerevisiae YOR114W Hypothetical ORF; mitochondrial HMG-box protein CIM1 2223757 2895294 KLLA0_F23804g Kluyveromyces lactis mitochondrial HMG-box protein CIM1 XP_456140.1 2222945 D 28985 CDS KLLA0_F23826g 2895295 complement(2223868..2224680) F 1 NC_006042.1 similar to uniprot|Q99394 Saccharomyces cerevisiae YOR115C TRS33 Component of the targeting complex (TRAPP) involved in ER to Golgi membrane traffic; uncharacterized protein 2224680 2895295 KLLA0_F23826g Kluyveromyces lactis uncharacterized protein XP_456141.1 2223868 R 28985 CDS KLLA0_F23848g 2895296 2224951..2226900 F 1 NC_006042.1 similar to uniprot|P38822 Saccharomyces cerevisiae YHR114W BZZ1 SH3 domain protein implicated in the regulation of actin polymerization able to recruit actin polymerization machinery through its SH3 domains colocalizes with cortical actin patches and Las17p interacts with type I myosins; uncharacterized protein 2226900 2895296 KLLA0_F23848g Kluyveromyces lactis uncharacterized protein XP_456142.1 2224951 D 28985 CDS KLLA0_F23870g 2895297 2227310..2229253 F 1 NC_006042.1 similar to uniprot|P53925 Saccharomyces cerevisiae YNL115C Hypothetical ORF; uncharacterized protein 2229253 2895297 KLLA0_F23870g Kluyveromyces lactis uncharacterized protein XP_456143.1 2227310 D 28985 CDS KLLA0_F23892g 2895298 complement(2229493..2231049) F 1 NC_006042.1 some similarities with uniprot|P53924 Saccharomyces cerevisiae YNL116W DMA2 Protein involved in regulating spindle position and orientation functionally redundant with Dma1p homolog of S. pombe Dma1 and H. sapiens Chfr; ubiquitin-conjugating protein DMA2 2231049 2895298 KLLA0_F23892g Kluyveromyces lactis ubiquitin-conjugating protein DMA2 XP_456144.1 2229493 R 28985 CDS KLLA0_F23914g 2895299 complement(2232014..2233681) F 1 NC_006042.1 highly similar to uniprot|P30952 Saccharomyces cerevisiae YNL117W MLS1 Malate synthase enzyme of the glyoxylate cycle involved in utilization of non-fermentable carbon sources expression is subject to carbon catabolite repression localizes in peroxisomes during growth in oleic acid medium; malate synthase MLS1 2233681 2895299 KLLA0_F23914g Kluyveromyces lactis malate synthase MLS1 XP_456145.1 2232014 R 28985 CDS KLLA0_F23980g 2895228 2235183..2237615 F 1 NC_006042.1 similar to uniprot|P53550 Saccharomyces cerevisiae YNL118C DCP2 Protein required for the decapping of mRNAs functions to allow the production of active Dcp1p contains a pyrophosphatase MutT motif and several alpha-helical leucine-rich motifs; decapping enzyme complex catalytic subunit 2237615 2895228 KLLA0_F23980g Kluyveromyces lactis decapping enzyme complex catalytic subunit XP_456148.1 2235183 D 28985 CDS KLLA0_F24002g 2895229 complement(2237722..2239113) F 1 NC_006042.1 similar to uniprot|P53923 Saccharomyces cerevisiae YNL119W NCS2 Protein with a role in urmylation and in invasive and pseudohyphal growth inhibits replication of Brome mosaic virus in S. cerevisiae which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; uncharacterized protein 2239113 2895229 KLLA0_F24002g Kluyveromyces lactis uncharacterized protein XP_456149.1 2237722 R 28985 CDS KLLA0_F24024g 2895230 2239420..2239788 F 1 NC_006042.1 similar to uniprot|P38824 Saccharomyces cerevisiae YHR116W COX23 Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis essential for functional cytochrome oxidase expression homologous to Cox17p; uncharacterized protein 2239788 2895230 KLLA0_F24024g Kluyveromyces lactis uncharacterized protein XP_456150.1 2239420 D 28985 CDS KLLA0_F24046g 2895231 2240454..2242268 F 1 NC_006042.1 similar to uniprot|P07213 Saccharomyces cerevisiae YNL121C TOM70 Translocase of Outer Mitochondrial membrane 70 kDa mitochondrial specialized import receptor of the outer membrane; protein channel TOM70 2242268 2895231 KLLA0_F24046g Kluyveromyces lactis protein channel TOM70 XP_456151.1 2240454 D 28985 CDS KLLA0_F24068g 2895232 2242939..2243226 F 1 NC_006042.1 similar to uniprot|P53921 Saccharomyces cerevisiae YNL122C Hypothetical ORF; mitochondrial 54S ribosomal protein bL35m 2243226 2895232 KLLA0_F24068g Kluyveromyces lactis mitochondrial 54S ribosomal protein bL35m XP_456152.1 2242939 D 28985 CDS KLLA0_F24090g 2895233 complement(2243449..2246406) F 1 NC_006042.1 similar to uniprot|P53920 Saccharomyces cerevisiae YNL123W shows protein sequence similarity to the mammalian Omi/HtrA2 family of serine proteases; uncharacterized protein 2246406 2895233 KLLA0_F24090g Kluyveromyces lactis uncharacterized protein XP_456153.1 2243449 R 28985 CDS KLLA0_F24112g 2895234 complement(2246666..2247916) F 1 NC_006042.1 similar to uniprot|P38826 Saccharomyces cerevisiae YHR118C ORC6 Subunit of the origin recognition complex which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing may be phosphorylated by Cdc28p; origin recognition complex subunit 6 2247916 2895234 KLLA0_F24112g Kluyveromyces lactis origin recognition complex subunit 6 XP_456154.1 2246666 R 28985 CDS KLLA0_F24134g 2895235 2248261..2251263 F 1 NC_006042.1 similar to uniprot|P38827 Saccharomyces cerevisiae YHR119W SET1 Histone methyltransferase subunit of the COMPASS complex which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres contains a SET domain; histone methyltransferase SET1 2251263 2895235 KLLA0_F24134g Kluyveromyces lactis histone methyltransferase SET1 XP_456155.1 2248261 D 28985 CDS KLLA0_F24156g 2895236 2251454..2254276 F 1 NC_006042.1 similar to uniprot|P25846 Saccharomyces cerevisiae YHR120W MSH1 DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA has ATPase activity and binds to DNA mismatches has homology to E. coli MutS transcription is induced during meiosis; mismatch repair ATPase MSH1 2254276 2895236 KLLA0_F24156g Kluyveromyces lactis mismatch repair ATPase MSH1 XP_456156.1 2251454 D 28985 CDS KLLA0_F24178g 2895237 complement(2254372..2255829) F 1 NC_006042.1 some similarities with uniprot|P53919 Saccharomyces cerevisiae YNL124W NAF1 Protein required for the assembly of box H/ACA snoRNPs and for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; RNA-binding snoRNP assembly protein 2255829 2895237 KLLA0_F24178g Kluyveromyces lactis RNA-binding snoRNP assembly protein XP_456157.1 2254372 R 28985 CDS KLLA0_F24200g 2895238 2257007..2258965 F 1 NC_006042.1 similar to uniprot|P53918 Saccharomyces cerevisiae YNL125C ESBP6 Protein with similarity to monocarboxylate permeases appears not to be involved in transport of monocarboxylates such as lactate pyruvate or acetate across the plasma membrane; uncharacterized protein 2258965 2895238 KLLA0_F24200g Kluyveromyces lactis uncharacterized protein XP_456158.1 2257007 D 28985 CDS KLLA0_F24222g 2895239 complement(2259017..2261497) F 1 NC_006042.1 similar to uniprot|P53540 YNL126W Saccharomyces cerevisiae SPC98 Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; uncharacterized protein 2261497 2895239 KLLA0_F24222g Kluyveromyces lactis uncharacterized protein XP_456159.1 2259017 R 28985 CDS KLLA0_F24244g 2895217 complement(2261810..2264593) F 1 NC_006042.1 similar to uniprot|P53917 Saccharomyces cerevisiae YNL127W FAR11 Protein involved in G1 cell cycle arrest in response to pheromone in a pathway different from the Far1p-dependent pathway interacts with Far3p Far7p Far8p Far9p and Far10p; uncharacterized protein 2264593 2895217 KLLA0_F24244g Kluyveromyces lactis uncharacterized protein XP_456160.1 2261810 R 28985 CDS KLLA0_F24266g 2895218 2265002..2265559 F 1 NC_006042.1 similar to uniprot|P38828 Saccharomyces cerevisiae YHR121W LSM12 Protein containing an Lsm domain and an AD domain may bind RNA and have a role in RNA processing; uncharacterized protein 2265559 2895218 KLLA0_F24266g Kluyveromyces lactis uncharacterized protein XP_456161.1 2265002 D 28985 CDS KLLA0_F24288g 2895219 complement(2265719..2267020) F 1 NC_006042.1 similar to uniprot|P53916 Saccharomyces cerevisiae YNL128W; uncharacterized protein 2267020 2895219 KLLA0_F24288g Kluyveromyces lactis uncharacterized protein XP_456162.1 2265719 R 28985 CDS KLLA0_F24310g 2895220 complement(2267285..2268013) F 1 NC_006042.1 similar to uniprot|P53915 Saccharomyces cerevisiae YNL129W NRK1 Nicotinamide riboside kinase catalyzes the synthesis of nicotinamide nucleotide (NMN) from nicotinamide riboside involved in a salvage pathway for NAD biosynthesis; ribosylnicotinamide kinase 2268013 2895220 KLLA0_F24310g Kluyveromyces lactis ribosylnicotinamide kinase XP_456163.1 2267285 R 28985 CDS KLLA0_F24332g 2895221 2268391..2269074 F 1 NC_006042.1 similar to uniprot|P38829 Saccharomyces cerevisiae YHR122W Protein required for cell viability; iron-sulfur cluster assembly protein CIA2 2269074 2895221 KLLA0_F24332g Kluyveromyces lactis iron-sulfur cluster assembly protein CIA2 XP_456164.1 2268391 D 28985 CDS KLLA0_F24354g 2895222 join(2269337..2269386,2269514..2270621) F 1 NC_006042.1 similar to uniprot|P17898 Saccharomyces cerevisiae YNL130C CPT1 and similar to uniprot|P22140 Saccharomyces cerevisiae YHR123w EPT1 Cholinephosphotransferase; diacylglycerol cholinephosphotransferase 2270621 2895222 KLLA0_F24354g Kluyveromyces lactis diacylglycerol cholinephosphotransferase XP_456165.2 2269337 D 28985 CDS KLLA0_F24376g 2895223 complement(2270907..2271371) F 1 NC_006042.1 similar to uniprot|P49334 Saccharomyces cerevisiae YNL131W TOM22 Translocase of Outer Mitochondrial membrane Mitochondrial import receptor complex protein; uncharacterized protein 2271371 2895223 KLLA0_F24376g Kluyveromyces lactis uncharacterized protein XP_456166.1 2270907 R 28985 CDS KLLA0_F24398g 2895224 complement(2271709..2274876) F 1 NC_006042.1 highly similar to uniprot|P53914 Saccharomyces cerevisiae YNL132W KRE33 Essential protein of unknown function heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance; ribosome biosynthesis protein KRE33 2274876 2895224 KLLA0_F24398g Kluyveromyces lactis ribosome biosynthesis protein KRE33 XP_456167.1 2271709 R 28985 CDS KLLA0_F24420g 2895225 2275736..2277472 F 1 NC_006042.1 some similarities with uniprot|P38830 Saccharomyces cerevisiae YHR124W NDT80 Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination activates middle sporulation genes competes with Sum1p for binding to promoters containing middle sporulation elements (MSE); transcription factor NDT80 2277472 2895225 KLLA0_F24420g Kluyveromyces lactis transcription factor NDT80 XP_456168.1 2275736 D 28985 CDS KLLA0_F24442g 2895226 2277836..2278330 F 1 NC_006042.1 weakly similar to uniprot|P53913 Saccharomyces cerevisiae YNL133C FYV6 Protein of unknown function required for survival upon exposure to K1 killer toxin proposed to regulate double-strand break repair via non-homologous end-joining; uncharacterized protein 2278330 2895226 KLLA0_F24442g Kluyveromyces lactis uncharacterized protein XP_456169.1 2277836 D 28985 CDS KLLA0_F24464g 2895227 2278745..2279857 F 1 NC_006042.1 similar to uniprot|P53912 Saccharomyces cerevisiae YNL134C similarity to dehydrogenases; uncharacterized protein 2279857 2895227 KLLA0_F24464g Kluyveromyces lactis uncharacterized protein XP_456170.1 2278745 D 28985 CDS KLLA0_F24486g 2895199 complement(2280372..2281223) F 1 NC_006042.1 some similarities with uniprot|P47179 Saccharomyces cerevisiae YJR151C DAN4 Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; uncharacterized protein 2281223 2895199 KLLA0_F24486g Kluyveromyces lactis uncharacterized protein XP_456171.1 2280372 R 28985 CDS KLLA0_F24509g 9487410 join(2282652..2282871,2282961..2283091) F 1 NC_006042.1 some similarities with uniprot|P13902 Saccharomyces cerevisiae YOL108C INO4 Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain; uncharacterized protein 2283091 9487410 KLLA0_F24509g Kluyveromyces lactis uncharacterized protein XP_002999438.1 2282652 D 28985 CDS KLLA0_F24552g 2895202 complement(2283569..2284717) F 1 NC_006042.1 similar to uniprot|P38071 Saccharomyces cerevisiae YBR026C ETR1 2-enoyl thioester reductase member of the medium chain dehydrogenase/reductase family localized to in mitochondria where it has a probable role in fatty acid synthesis; enoyl-[acyl-carrier-protein] reductase 2284717 2895202 KLLA0_F24552g Kluyveromyces lactis enoyl-[acyl-carrier-protein] reductase XP_456173.1 2283569 R 28985 CDS KLLA0_F24574g 2895203 complement(2285387..2287522) F 1 NC_006042.1 similar to uniprot|P38069 Saccharomyces cerevisiae YBR015C MNN2 Alpha-1 2-mannosyltransferase responsible for addition of the first alpha-1 2-linked mannose to form the branches on the mannan backbone of oligosaccharides localizes to an early Golgi compartment; uncharacterized protein 2287522 2895203 KLLA0_F24574g Kluyveromyces lactis uncharacterized protein XP_456174.1 2285387 R 28985 CDS KLLA0_F24596g 2895204 2288293..2288802 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 2288802 2895204 KLLA0_F24596g Kluyveromyces lactis uncharacterized protein XP_456175.1 2288293 D 28985 CDS KLLA0_F24618g 2895205 complement(2288943..2290613) F 1 NC_006042.1 similar to uniprot|P38070 Saccharomyces cerevisiae YBR028C Hypothetical ORF; uncharacterized protein 2290613 2895205 KLLA0_F24618g Kluyveromyces lactis uncharacterized protein XP_456176.1 2288943 R 28985 CDS KLLA0_F24640g 2895206 complement(2291186..2292508) F 1 NC_006042.1 similar to uniprot|P38221 Saccharomyces cerevisiae YBR029C CDS1 Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase) an enzyme that catalyzes that conversion of CTP phosphate into diphosphate CDP-diaclglyerol a critical step in the synthesis of all major yeast phospholipids; phosphatidate cytidylyltransferase 2292508 2895206 KLLA0_F24640g Kluyveromyces lactis phosphatidate cytidylyltransferase XP_456177.1 2291186 R 28985 CDS KLLA0_F24662g 2895207 complement(2292807..2294399) F 1 NC_006042.1 similar to uniprot|P19736 Saccharomyces cerevisiae YDL030W PRP9 Subunit of the SF3a splicing factor complex required for spliceosome assembly; SF3a splicing factor complex subunit PRP9 2294399 2895207 KLLA0_F24662g Kluyveromyces lactis SF3a splicing factor complex subunit PRP9 XP_456178.1 2292807 R 28985 CDS KLLA0_F24684g 2895208 complement(2294708..2297629) F 1 NC_006042.1 similar to uniprot|Q12389 Saccharomyces cerevisiae YDL031W DBP10 Essential protein involved in ribosome biogenesis; uncharacterized protein 2297629 2895208 KLLA0_F24684g Kluyveromyces lactis uncharacterized protein XP_456179.1 2294708 R 28985 CDS KLLA0_F24706g 2895209 2298224..2299471 F 1 NC_006042.1 similar to uniprot|Q12093 Saccharomyces cerevisiae YDL033C SLM3 Mitochondrial protein with a potential role in protein synthesis the bacterial homolog is responsible for the 2-thiolation of mnm5s2U34 in tRNALys tRNAGlu and tRNAGln; tRNA-5-taurinomethyluridine 2-sulfurtransferase 2299471 2895209 KLLA0_F24706g Kluyveromyces lactis tRNA-5-taurinomethyluridine 2-sulfurtransferase XP_456180.1 2298224 D 28985 CDS KLLA0_F24728g 2895210 2299815..2300906 F 1 NC_006042.1 similar to uniprot|P32179 Saccharomyces cerevisiae YOL064C MET22 Bisphosphate-3'-nucleotidase involved in salt tolerance and methionine biogenesis dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate intermediates of the sulfate assimilation pathway; 3'(2'),5'-bisphosphate nucleotidase 2300906 2895210 KLLA0_F24728g Kluyveromyces lactis 3'(2'),5'-bisphosphate nucleotidase XP_456181.1 2299815 D 28985 CDS KLLA0_F24750g 2895211 2301851..2304451 F 1 NC_006042.1 similar to uniprot|Q757V1 Ashbya gossypii AEL089C AEL089Cp and some similarites with YDL035C uniprot|Q12361 Saccharomyces cerevisiae YDL035C GPR1 Plasma membrane G-protein coupled receptor that interacts with the heterotrimeric G protein alpha subunit Gpa2p and with Plc1p sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis; uncharacterized protein 2304451 2895211 KLLA0_F24750g Kluyveromyces lactis uncharacterized protein XP_456182.1 2301851 D 28985 CDS KLLA0_F24772g 2895212 2304733..2305863 F 1 NC_006042.1 similar to uniprot|Q08227 Saccharomyces cerevisiae YOL065C INP54 Phosphatidylinositol 4 5-bisphosphate 5-phosphatase with a role in secretion localizes to the endoplasmic reticulum via the C-terminal tail lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins; phosphoinositide 5-phosphatase INP54 2305863 2895212 KLLA0_F24772g Kluyveromyces lactis phosphoinositide 5-phosphatase INP54 XP_456183.1 2304733 D 28985 CDS KLLA0_F24794g 2895213 2306055..2307848 F 1 NC_006042.1 similar to uniprot|Q12362 Saccharomyces cerevisiae and weakly similar to YDL036C uniprot|Q12069 Saccharomyces cerevisiae YDL036C Hypothetical ORF; uncharacterized protein 2307848 2895213 KLLA0_F24794g Kluyveromyces lactis uncharacterized protein XP_456184.1 2306055 D 28985 CDS KLLA0_F24816g 2895185 2308342..2309778 F 1 NC_006042.1 similar to uniprot|Q02555 Saccharomyces cerevisiae YMR239C RNT1 RNAase III cleaves a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end; ribonuclease III 2309778 2895185 KLLA0_F24816g Kluyveromyces lactis ribonuclease III XP_456185.1 2308342 D 28985 CDS KLLA0_F24838g 2895186 complement(2309842..2313030) F 1 NC_006042.1 similar to uniprot|Q08773 Saccharomyces cerevisiae YOR304W ISW2 Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes ATPase component that with Itc1p forms a complex required for repression of a-specific genes INO1 and early meiotic genes during mitotic growth; DNA translocase 2313030 2895186 KLLA0_F24838g Kluyveromyces lactis DNA translocase XP_456186.1 2309842 R 28985 CDS KLLA0_F24860g 2895187 complement(2313713..2317357) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 2317357 2895187 KLLA0_F24860g Kluyveromyces lactis uncharacterized protein XP_456187.1 2313713 R 28985 CDS KLLA0_F24882g 2895188 complement(2317798..2319027) F 1 NC_006042.1 similar to uniprot|P07258 Saccharomyces cerevisiae YOR303W CPA1 Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader, member of GLC.2530; carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1 2319027 2895188 KLLA0_F24882g Kluyveromyces lactis carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1 XP_456188.1 2317798 R 28985 CDS KLLA0_F24904g 2895189 complement(2319858..2321132) F 1 NC_006042.1 similar to uniprot|Q08760 Saccharomyces cerevisiae YOR301W RAX1 Protein involved in bud site selection during bipolar budding localization requires Rax2p; uncharacterized protein 2321132 2895189 KLLA0_F24904g Kluyveromyces lactis uncharacterized protein XP_456189.1 2319858 R 28985 CDS KLLA0_F24926g 2895190 complement(2321928..2323283) F 1 NC_006042.1 similar to uniprot|Q05031 Saccharomyces cerevisiae YMR238W DFG5 Mannosidase essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis involved in filamentous growth homologous to Dcw1p; uncharacterized protein 2323283 2895190 KLLA0_F24926g Kluyveromyces lactis uncharacterized protein XP_456190.1 2321928 R 28985 CDS KLLA0_F24948g 2895191 complement(2323980..2324480) F 1 NC_006042.1 similar to uniprot|Q88DE0 Pseudomonas putida PP4887 PP_4887 Hypothetical protein; uncharacterized protein 2324480 2895191 KLLA0_F24948g Kluyveromyces lactis uncharacterized protein XP_456191.1 2323980 R 28985 CDS KLLA0_F24981g 2895193 complement(2325340..2327283) F 1 NC_006042.1 similar to uniprot|Q08754 Saccharomyces cerevisiae YOR299W BUD7 Protein involved in bud-site selection diploid mutants display an axial-like budding pattern; uncharacterized protein 2327283 2895193 KLLA0_F24981g Kluyveromyces lactis uncharacterized protein XP_456193.1 2325340 R 28985 CDS KLLA0_F25003g 2895194 complement(2327810..2328208) F 1 NC_006042.1 highly similar to uniprot|Q05027 Saccharomyces cerevisiae YMR236W TAF9; chromatin modification protein 2328208 2895194 KLLA0_F25003g Kluyveromyces lactis chromatin modification protein XP_456194.1 2327810 R 28985 CDS KLLA0_F25014g 2895195 2328545..2328997 F 1 NC_006042.1 some similarities with uniprot|Q86ZS7 Saccharomyces cerevisiae YOR298C-A MBF1 Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; multiprotein-bridging factor 1 2328997 2895195 KLLA0_F25014g Kluyveromyces lactis multiprotein-bridging factor 1 XP_456195.2 2328545 D 28985 CDS KLLA0_F25036g 2895196 2329465..2330634 F 1 NC_006042.1 similar to uniprot|P11745 Saccharomyces cerevisiae YMR235C RNA1 GTPase activating protein (GAP) for Gsp1p involved in nuclear transport; GTPase-activating protein RNA1 2330634 2895196 KLLA0_F25036g Kluyveromyces lactis GTPase-activating protein RNA1 XP_456196.1 2329465 D 28985 CDS KLLA0_F25058g 2895197 complement(2330789..2331805) F 1 NC_006042.1 weakly similar to uniprot|Q08750 Saccharomyces cerevisiae YOR298W MUM3 Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acetyltransferases; uncharacterized protein 2331805 2895197 KLLA0_F25058g Kluyveromyces lactis uncharacterized protein XP_456197.1 2330789 R 28985 CDS KLLA0_F25080g 2895198 2332264..2332845 F 1 NC_006042.1 some similarities with uniprot|Q08749 Saccharomyces cerevisiae YOR297C TIM18 mitochondrial inner membrane translocase; uncharacterized protein 2332845 2895198 KLLA0_F25080g Kluyveromyces lactis uncharacterized protein XP_456198.1 2332264 D 28985 CDS KLLA0_F25102g 2895176 2333488..2334798 F 1 NC_006042.1 similar to uniprot|P06842 Saccharomyces cerevisiae YFL026W STE2 Receptor for alpha-factor pheromone seven transmembrane-domain protein that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells; alpha-factor pheromone receptor STE2 2334798 2895176 KLLA0_F25102g Kluyveromyces lactis alpha-factor pheromone receptor STE2 XP_456199.1 2333488 D 28985 CDS KLLA0_F25124g 2895177 complement(2334954..2337881) F 1 NC_006042.1 similar to uniprot|P43571 Saccharomyces cerevisiae YFL025C BST1 GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation prevents production of vesicles with defective subunits required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules; uncharacterized protein 2337881 2895177 KLLA0_F25124g Kluyveromyces lactis uncharacterized protein XP_456200.1 2334954 R 28985 CDS KLLA0_F25146g 2895178 complement(2338211..2340631) F 1 NC_006042.1 similar to uniprot|P43572 Saccharomyces cerevisiae YFL024C EPL1 Component of NuA4 which is an essential histone H4/H2A acetyltransferase complex homologous to Drosophila Enhancer of Polycomb; uncharacterized protein 2340631 2895178 KLLA0_F25146g Kluyveromyces lactis uncharacterized protein XP_456201.1 2338211 R 28985 CDS KLLA0_F25168g 2895179 2341386..2343614 F 1 NC_006042.1 similar to uniprot|P43573 Saccharomyces cerevisiae YFL023W BUD27 Protein involved in bud-site selection nutrient signaling and gene expression controlled by the TOR kinase diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; uncharacterized protein 2343614 2895179 KLLA0_F25168g Kluyveromyces lactis uncharacterized protein XP_456202.1 2341386 D 28985 CDS KLLA0_F25190g 2895180 2345059..2346723 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 2346723 2895180 KLLA0_F25190g Kluyveromyces lactis uncharacterized protein XP_456203.1 2345059 D 28985 CDS KLLA0_F25212g 2895181 2347143..2349122 F 1 NC_006042.1 some similarities with uniprot|Q12202 Saccharomyces cerevisiae YLR054C OSW2 Protein of unknown function proposed to be involved in the assembly of the spore wall; uncharacterized protein 2349122 2895181 KLLA0_F25212g Kluyveromyces lactis uncharacterized protein XP_456204.1 2347143 D 28985 CDS KLLA0_F25234g 2895182 complement(2349192..2350691) F 1 NC_006042.1 highly similar to uniprot|P15625 Saccharomyces cerevisiae YFL022C; phenylalanine--tRNA ligase subunit alpha 2350691 2895182 KLLA0_F25234g Kluyveromyces lactis phenylalanine--tRNA ligase subunit alpha XP_456205.1 2349192 R 28985 CDS KLLA0_F25256g 2895183 complement(2351009..2351602) F 1 NC_006042.1 weakly similar to uniprot|Q12345 Saccharomyces cerevisiae YLR052W IES3 Subunit of the INO80 chromatin remodeling complex; uncharacterized protein 2351602 2895183 KLLA0_F25256g Kluyveromyces lactis uncharacterized protein XP_456206.1 2351009 R 28985 CDS KLLA0_F25278g 2895184 2352045..2352719 F 1 NC_006042.1 similar to uniprot|Q12035 Saccharomyces cerevisiae YLR051C Protein required for cell viability; uncharacterized protein 2352719 2895184 KLLA0_F25278g Kluyveromyces lactis uncharacterized protein XP_456207.1 2352045 D 28985 CDS KLLA0_F25300g 2895161 2354118..2356196 F 1 NC_006042.1 some similarities with uniprot|P43574 Saccharomyces cerevisiae YFL021W GAT1 Transcriptional activator of genes involved in nitrogen catabolite repression member of the GATA family of DNA binding proteins activity and localization regulated by nitrogen limitation and Ure2p; uncharacterized protein 2356196 2895161 KLLA0_F25300g Kluyveromyces lactis uncharacterized protein XP_456208.1 2354118 D 28985 CDS KLLA0_F25322g 2895162 complement(2356566..2360375) F 1 NC_006042.1 similar to uniprot|Q03690 Saccharomyces cerevisiae YMR012W; translation initiation factor 3 subunit CLU1 2360375 2895162 KLLA0_F25322g Kluyveromyces lactis translation initiation factor 3 subunit CLU1 XP_456209.1 2356566 R 28985 CDS KLLA0_F25366g 2895164 2361279..2361953 F 1 NC_006042.1 similar to uniprot|P36095 Saccharomyces cerevisiae YKL041W VPS24 involved in secretion; ESCRT-III subunit protein VPS24 2361953 2895164 KLLA0_F25366g Kluyveromyces lactis ESCRT-III subunit protein VPS24 XP_456210.1 2361279 D 28985 CDS KLLA0_F25388g 2895165 complement(2362150..2363367) F 1 NC_006042.1 some similarities with uniprot|P21957 Saccharomyces cerevisiae YHL020C OPI1 Transcriptional regulator of a variety of genes phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; transcriptional regulator OPI1 2363367 2895165 KLLA0_F25388g Kluyveromyces lactis transcriptional regulator OPI1 XP_456211.1 2362150 R 28985 CDS KLLA0_F25410g 2895166 2363911..2365374 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 2365374 2895166 KLLA0_F25410g Kluyveromyces lactis uncharacterized protein XP_456212.1 2363911 D 28985 CDS KLLA0_F25432g 2895167 complement(2365434..2366957) F 1 NC_006042.1 some similarities with uniprot|P38700 Saccharomyces cerevisiae YHL019C APM2 homologous to the medium chain of mammalian clathrin-associated protein complex Similar to clathrin coat proteins; uncharacterized protein 2366957 2895167 KLLA0_F25432g Kluyveromyces lactis uncharacterized protein XP_456213.1 2365434 R 28985 CDS KLLA0_F25454g 2895168 2367059..2367586 F 1 NC_006042.1 similar to uniprot|P38744 Saccharomyces cerevisiae YHL018W Hypothetical ORF; 4a-hydroxytetrahydrobiopterin dehydratase 2367586 2895168 KLLA0_F25454g Kluyveromyces lactis 4a-hydroxytetrahydrobiopterin dehydratase XP_456214.1 2367059 D 28985 CDS KLLA0_F25476g 2895169 complement(2367737..2368507) F 1 NC_006042.1 similar to uniprot|P32860 Saccharomyces cerevisiae YKL040C; uncharacterized protein 2368507 2895169 KLLA0_F25476g Kluyveromyces lactis uncharacterized protein XP_456215.1 2367737 R 28985 CDS KLLA0_F25498g 2895170 2368996..2370501 F 1 NC_006042.1 similar to uniprot|P32857 Saccharomyces cerevisiae YKL039W PTM1 Putative membrane protein; uncharacterized protein 2370501 2895170 KLLA0_F25498g Kluyveromyces lactis uncharacterized protein XP_456216.1 2368996 D 28985 CDS KLLA0_F25520g 2895171 complement(2370884..2372155) F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 2372155 2895171 KLLA0_F25520g Kluyveromyces lactis uncharacterized protein XP_456217.1 2370884 R 28985 CDS KLLA0_F25542g 2895172 2372720..2373073 F 1 NC_006042.1 similar to uniprot|P38701 Saccharomyces cerevisiae YHL015W RPS20; 40S ribosomal protein uS10 2373073 2895172 KLLA0_F25542g Kluyveromyces lactis 40S ribosomal protein uS10 XP_456218.1 2372720 D 28985 CDS KLLA0_F25564g 2895173 complement(2374193..2375422) F 1 NC_006042.1 similar to uniprot|P38746 Saccharomyces cerevisiae YHL014C YLF2 Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; uncharacterized protein 2375422 2895173 KLLA0_F25564g Kluyveromyces lactis uncharacterized protein XP_456219.1 2374193 R 28985 CDS KLLA0_F25586g 2895174 complement(2375616..2376569) F 1 NC_006042.1 similar to uniprot|P38747 Saccharomyces cerevisiae YHL013C Hypothetical ORF; uncharacterized protein 2376569 2895174 KLLA0_F25586g Kluyveromyces lactis uncharacterized protein XP_456220.1 2375616 R 28985 CDS KLLA0_F25630g 2895143 2378464..2381487 F 1 NC_006042.1 some similarities with uniprot|P32862 Saccharomyces cerevisiae YKL038W RGT1 Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose binds to promoters and acts both as a transcriptional activator and repressor; uncharacterized protein 2381487 2895143 KLLA0_F25630g Kluyveromyces lactis uncharacterized protein XP_456221.1 2378464 D 28985 CDS KLLA0_F25652g 2895144 2382288..2383790 F 1 NC_006042.1 highly similar to uniprot|P32861 Saccharomyces cerevisiae YKL035W UGP1 UDP-glucose pyrophosphorylase or UTP-glucose-1-phosphate uridylyltransferase EC:2.7.7.9; uncharacterized protein 2383790 2895144 KLLA0_F25652g Kluyveromyces lactis uncharacterized protein XP_456222.1 2382288 D 28985 CDS KLLA0_F25674g 2895145 2384293..2386566 F 1 NC_006042.1 similar to uniprot|P36096 Saccharomyces cerevisiae YKL034W TUL1 Transmembrane Ubiquitin Ligase; ubiquitin-protein ligase TUL1 2386566 2895145 KLLA0_F25674g Kluyveromyces lactis ubiquitin-protein ligase TUL1 XP_456223.1 2384293 D 28985 CDS KLLA0_F25696g 2895146 2386886..2387554 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 2387554 2895146 KLLA0_F25696g Kluyveromyces lactis uncharacterized protein XP_456224.1 2386886 D 28985 CDS KLLA0_F25718g 2895147 complement(2387821..2388783) F 1 NC_006042.1 highly similar to uniprot|P38689 Saccharomyces cerevisiae YHL011C PRS3 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase involved in nucleotide histidine and tryptophan biosynthesis one of a five related enzymes which are active as heteromultimeric complexes; ribose phosphate diphosphokinase subunit PRS3 2388783 2895147 KLLA0_F25718g Kluyveromyces lactis ribose phosphate diphosphokinase subunit PRS3 XP_456225.1 2387821 R 28985 CDS KLLA0_F25740g 2895148 complement(2389226..2390779) F 1 NC_006042.1 similar to uniprot|P38748 YHL010C Saccharomyces cerevisiae Hypothetical ORF; uncharacterized protein 2390779 2895148 KLLA0_F25740g Kluyveromyces lactis uncharacterized protein XP_456226.1 2389226 R 28985 CDS KLLA0_F25762g 2895149 2391115..2394126 F 1 NC_006042.1 weakly similar to uniprot|P36097 Saccharomyces cerevisiae YKL033W Protein of unknown function localized to the cytoplasm.; uncharacterized protein 2394126 2895149 KLLA0_F25762g Kluyveromyces lactis uncharacterized protein XP_456227.1 2391115 D 28985 CDS KLLA0_F25784g 2895150 2395004..2397058 F 1 NC_006042.1 similar to uniprot|P38750 Saccharomyces cerevisiae YHL008C Hypothetical ORF; uncharacterized protein 2397058 2895150 KLLA0_F25784g Kluyveromyces lactis uncharacterized protein XP_456228.1 2395004 D 28985 CDS KLLA0_F25806g 2895151 2397560..2401294 F 1 NC_006042.1 similar to uniprot|Q04264 Saccharomyces cerevisiae YMR076C PDS5 Protein required for establishment and maintenance of sister chromatid condensation and cohesion colocalizes with cohesin on chromosomes in an interdependent manner may function as a protein-protein interaction scaffold; uncharacterized protein 2401294 2895151 KLLA0_F25806g Kluyveromyces lactis uncharacterized protein XP_456229.1 2397560 D 28985 CDS KLLA0_F25828g 2895152 complement(2401463..2403334) F 1 NC_006042.1 similar to uniprot|Q04779 Saccharomyces cerevisiae YMR075W RCO1 Nuclear protein of unknown function; uncharacterized protein 2403334 2895152 KLLA0_F25828g Kluyveromyces lactis uncharacterized protein XP_456230.1 2401463 R 28985 CDS KLLA0_F25850g 2895153 2403616..2404017 F 1 NC_006042.1 weakly similar to uniprot|Q04773 Saccharomyces cerevisiae YMR074C Hypothetical ORF; uncharacterized protein 2404017 2895153 KLLA0_F25850g Kluyveromyces lactis uncharacterized protein XP_456231.1 2403616 D 28985 CDS KLLA0_F25872g 2895154 2404449..2404718 F 1 NC_006042.1 similar to uniprot|P87108 Saccharomyces cerevisiae YHR005C-A MRS11 Essential protein of the mitochondrial intermembrane space forms a complex with Tim9p (TIM10 complex) that mediates insertion of hydrophobic proteins at the inner membrane has homology to Mrs5p which is also involved in this process; protein transporter TIM10 2404718 2895154 KLLA0_F25872g Kluyveromyces lactis protein transporter TIM10 XP_456232.1 2404449 D 28985 CDS KLLA0_F25894g 2895155 complement(2405016..2405831) F 1 NC_006042.1 similar to uniprot|Q00873 Saccharomyces cerevisiae YKL087C CYT2 Cytochrome c1 heme lyase involved in maturation of cytochrome c1 which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase links heme covalently to apocytochrome c1; cytochrome c1 heme lyase CYT2 2405831 2895155 KLLA0_F25894g Kluyveromyces lactis cytochrome c1 heme lyase CYT2 XP_456233.1 2405016 R 28985 CDS KLLA0_F25916g 2894996 2406597..2407940 F 1 NC_006042.1 uniprot|Q9Y7B7 Kluyveromyces lactis KLLA0F25916g GPA1 Guanine nucleotide-binding protein alpha-1 subunit; guanine nucleotide-binding protein subunit alpha 2407940 2894996 KLLA0_F25916g Kluyveromyces lactis guanine nucleotide-binding protein subunit alpha XP_456234.1 2406597 D 28985 CDS KLLA0_F25938g 2895156 2408281..2408679 F 1 NC_006042.1 similar to uniprot|P36077 Saccharomyces cerevisiae YKL086W SRX1 Sulfiredoxin contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxins Tsa1p and Ahp1p that are formed upon exposure to oxidants conserved in higher eukaryotes; sulfiredoxin 2408679 2895156 KLLA0_F25938g Kluyveromyces lactis sulfiredoxin XP_456235.1 2408281 D 28985 CDS KLLA0_F25960g 2895134 2409591..2410607 F 1 NC_006042.1 highly similar to uniprot|P17505 Saccharomyces cerevisiae YKL085W MDH1 Mitochondrial malate dehydrogenase catalyzes interconversion of malate and oxaloacetate involved in the tricarboxylic acid (TCA) cycle; malate dehydrogenase MDH1 2410607 2895134 KLLA0_F25960g Kluyveromyces lactis malate dehydrogenase MDH1 XP_456236.1 2409591 D 28985 CDS KLLA0_F25982g 2895135 2410900..2411244 F 1 NC_006042.1 similar to uniprot|P36078 Saccharomyces cerevisiae YKL084W HOT13 Mitochondrial intermembrane space protein first component of a pathway mediating assembly of small TIM (Translocase of the Inner Membrane) complexes which escort hydrophobic inner membrane proteins en route to the TIM22 complex; uncharacterized protein 2411244 2895135 KLLA0_F25982g Kluyveromyces lactis uncharacterized protein XP_456237.1 2410900 D 28985 CDS KLLA0_F26004g 2895136 complement(2411261..2412271) F 1 NC_006042.1 some similarities with uniprot|Q04749 Saccharomyces cerevisiae YMR068W AVO2 Component of a complex containing the Tor2p kinase and other proteins; uncharacterized protein 2412271 2895136 KLLA0_F26004g Kluyveromyces lactis uncharacterized protein XP_456238.1 2411261 R 28985 CDS KLLA0_F26026g 2895137 2412582..2413241 F 1 NC_006042.1 some similarities with uniprot|P54730 Saccharomyces cerevisiae YMR067C UBX4 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; uncharacterized protein 2413241 2895137 KLLA0_F26026g Kluyveromyces lactis uncharacterized protein XP_456239.1 2412582 D 28985 CDS KLLA0_F26048g 2895138 complement(2413296..2415875) F 1 NC_006042.1 weakly similar to uniprot|Q04748 Saccharomyces cerevisiae YMR066W SOV1 Synthesis Of Var (putative) involved in respiration; uncharacterized protein 2415875 2895138 KLLA0_F26048g Kluyveromyces lactis uncharacterized protein XP_456240.1 2413296 R 28985 CDS KLLA0_F26070g 2895139 complement(2416265..2417608) F 1 NC_006042.1 similar to uniprot|P36080 Saccharomyces cerevisiae YKL082C RRP14 Required for normal pre-rRNA Processing Protein required for cell viability; ribosome biosynthesis protein RRP14 2417608 2895139 KLLA0_F26070g Kluyveromyces lactis ribosome biosynthesis protein RRP14 XP_456241.1 2416265 R 28985 CDS KLLA0_F26092g 2895140 join(2418244..2418622,2418992..2420028) F 1 NC_006042.1 similar to uniprot|P36008 Saccharomyces cerevisiae YKL081W TEF4 Translation elongation factor EF-1gamma; translation elongation factor EF1B gamma 2420028 2895140 KLLA0_F26092g Kluyveromyces lactis translation elongation factor EF1B gamma XP_456242.2 2418244 D 28985 CDS KLLA0_F26114g 2895141 2420635..2421810 F 1 NC_006042.1 highly similar to uniprot|P31412 Saccharomyces cerevisiae YKL080W VMA5 Vacuolar H ATPase subunit C of the catalytic (V1) sector; H(+)-transporting V1 sector ATPase subunit C 2421810 2895141 KLLA0_F26114g Kluyveromyces lactis H(+)-transporting V1 sector ATPase subunit C XP_456243.1 2420635 D 28985 CDS KLLA0_F26158g 2894829 2422976..2424154 F 1 NC_006042.1 similar to uniprot|Q12358 Saccharomyces cerevisiae YLL057C JLP1 to Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; sulfonate dioxygenase 2424154 2894829 KLLA0_F26158g Kluyveromyces lactis sulfonate dioxygenase XP_456245.1 2422976 D 28985 CDS KLLA0_F26180g 2894830 complement(2424326..2425789) F 1 NC_006042.1 similar to uniprot|Q04746 Saccharomyces cerevisiae YMR065W KAR5 Protein required for nuclear membrane fusion during karyogamy localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen may form a complex with Jem1p and Kar2p expression of the gene is regulated by pheromone; uncharacterized protein 2425789 2894830 KLLA0_F26180g Kluyveromyces lactis uncharacterized protein XP_456246.1 2424326 R 28985 CDS KLLA0_F26202g 2894831 complement(2426058..2427530) F 1 NC_006042.1 weakly similar to uniprot|P32493 Saccharomyces cerevisiae YMR064W AEP1 Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase; uncharacterized protein 2427530 2894831 KLLA0_F26202g Kluyveromyces lactis uncharacterized protein XP_456247.1 2426058 R 28985 CDS KLLA0_F26224g 2894832 2428360..2430558 F 1 NC_006042.1 similar to uniprot|P36009 Saccharomyces cerevisiae YKL078W DHR2 Predominantly nucleolar DEAH-box RNA helicase required for 18S rRNA synthesis; RNA helicase 2430558 2894832 KLLA0_F26224g Kluyveromyces lactis RNA helicase XP_456248.1 2428360 D 28985 CDS KLLA0_F26246g 2894833 2432209..2433960 F 1 NC_006042.1 highly similar to uniprot|P39932 Saccharomyces cerevisiae YDR536W STL1 Glycerol proton symporter of the plasma membrane subject to glucose-induced inactivation strongly but transiently induced when cells are subjected to osmotic shock; glucose-inactivated glycerol proton symporter STL1 2433960 2894833 KLLA0_F26246g Kluyveromyces lactis glucose-inactivated glycerol proton symporter STL1 XP_456249.1 2432209 D 28985 CDS KLLA0_F26268g 2894834 2434995..2436320 F 1 NC_006042.1 highly similar to uniprot|Q04728 Saccharomyces cerevisiae YMR062C ECM40 Mitochondrial ornithine acetyltransferase catalyzes the fifth step in arginine biosynthesis also possesses acetylglutamate synthase activity regenerates acetylglutamate while forming ornithine; glutamate N-acetyltransferase 2436320 2894834 KLLA0_F26268g Kluyveromyces lactis glutamate N-acetyltransferase XP_456250.1 2434995 D 28985 CDS KLLA0_F26290g 2894835 complement(2436415..2438400) F 1 NC_006042.1 similar to uniprot|P25298 Saccharomyces cerevisiae YMR061W RNA14 Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends bridges interaction between Rna15p and Hrp1p in the CF I complex; cleavage polyadenylation factor subunit RNA14 2438400 2894835 KLLA0_F26290g Kluyveromyces lactis cleavage polyadenylation factor subunit RNA14 XP_456251.1 2436415 R 28985 CDS KLLA0_F26312g 2894836 2438840..2439745 F 1 NC_006042.1 similar to uniprot|P50110 Saccharomyces cerevisiae YMR060C SAM37 Component of the mitochondrial outer membrane sorting and assembly machinery (SAM) complex required for the sorting of some proteins to the outer membrane after import by the TOM complex; SAM complex subunit SAM37 2439745 2894836 KLLA0_F26312g Kluyveromyces lactis SAM complex subunit SAM37 XP_456252.1 2438840 D 28985 CDS KLLA0_F26334g 2894837 complement(2439808..2440191) F 1 NC_006042.1 weakly similar to uniprot|Q04675 Saccharomyces cerevisiae YMR059W SEN15 Subunit of the tRNA splicing endonuclease which is composed of Sen2p Sen15p Sen34p and Sen54p; uncharacterized protein 2440191 2894837 KLLA0_F26334g Kluyveromyces lactis uncharacterized protein XP_456253.1 2439808 R 28985 CDS KLLA0_F26356g 2894838 2440510..2441676 F 1 NC_006042.1 similar to uniprot|P36081 Saccharomyces cerevisiae YKL077W; uncharacterized protein 2441676 2894838 KLLA0_F26356g Kluyveromyces lactis uncharacterized protein XP_456254.1 2440510 D 28985 CDS KLLA0_F26378g 2894839 complement(2441942..2443060) F 1 NC_006042.1 similar to uniprot|P36083 Saccharomyces cerevisiae YKL075C Hypothetical ORF; uncharacterized protein 2443060 2894839 KLLA0_F26378g Kluyveromyces lactis uncharacterized protein XP_456255.1 2441942 R 28985 CDS KLLA0_F26400g 2894840 complement(2443630..2445525) F 1 NC_006042.1 similar to uniprot|P38993 Saccharomyces cerevisiae YMR058W FET3 Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity belongs to class of integral membrane multicopper oxidases; ferroxidase FET3 2445525 2894840 KLLA0_F26400g Kluyveromyces lactis ferroxidase FET3 XP_456256.1 2443630 R 28985 CDS KLLA0_F26422g 2894841 2447842..2448753 F 1 NC_006042.1 similar to uniprot|P26448 Saccharomyces cerevisiae YMR055C BUB2 Mitotic exit network regulator forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies blocks cell cycle progression before anaphase in response to spindle and kinetochore damage; uncharacterized protein 2448753 2894841 KLLA0_F26422g Kluyveromyces lactis uncharacterized protein XP_456257.1 2447842 D 28985 CDS KLLA0_F26433g 2894842 complement(2448748..2450517) F 1 NC_006042.1 weakly similar to uniprot|P36084 Saccharomyces cerevisiae YKL074C; uncharacterized protein 2450517 2894842 KLLA0_F26433g Kluyveromyces lactis uncharacterized protein XP_456258.1 2448748 R 28985 CDS KLLA0_F26455g 2894852 2450871..2453462 F 1 NC_006042.1 similar to uniprot|P36016 Saccharomyces cerevisiae YKL073W LHS1 Molecular chaperone of the endoplasmic reticulum lumen involved in polypeptide translocation and folding member of the Hsp70 family localizes to the lumen of the ER regulated by the unfolded protein response pathway; Hsp70 family chaperone LHS1 2453462 2894852 KLLA0_F26455g Kluyveromyces lactis Hsp70 family chaperone LHS1 XP_456259.1 2450871 D 28985 CDS KLLA0_F26477g 2894853 complement(2453526..2456141) F 1 NC_006042.1 similar to uniprot|P37296 Saccharomyces cerevisiae YMR054W STV1 Subunit of vacuolar-ATPase V0 domain one of two isoforms (Stv1p and Vph1p) Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole; H(+)-transporting V0 sector ATPase subunit a 2456141 2894853 KLLA0_F26477g Kluyveromyces lactis H(+)-transporting V0 sector ATPase subunit a XP_456260.1 2453526 R 28985 CDS KLLA0_F26499g 2894854 2456560..2458689 F 1 NC_006042.1 similar to uniprot|P36085 Saccharomyces cerevisiae YKL072W STB6 and similar to uniprot|P46679 Saccharomyces cerevisiae YMR053c STB2; uncharacterized protein 2458689 2894854 KLLA0_F26499g Kluyveromyces lactis uncharacterized protein XP_456261.1 2456560 D 28985 CDS KLLA0_F26521g 2894855 complement(2458708..2459337) F 1 NC_006042.1 similar to uniprot|P46671 Saccharomyces cerevisiae YMR052W FAR3 Protein involved in G1 cell cycle arrest in response to pheromone in a pathway different from the Far1p-dependent pathway interacts with Far7p Far8p Far9p Far10p and Far11p; uncharacterized protein 2459337 2894855 KLLA0_F26521g Kluyveromyces lactis uncharacterized protein XP_456262.1 2458708 R 28985 CDS KLLA0_F26587g 2894857 2460142..2460672 F 1 NC_006042.1 highly similar to uniprot|P36088 Saccharomyces cerevisiae YKL069W Hypothetical ORF; L-methionine (R)-S-oxide reductase 2460672 2894857 KLLA0_F26587g Kluyveromyces lactis L-methionine (R)-S-oxide reductase XP_456263.1 2460142 D 28985 CDS KLLA0_F26653g 2894861 2461876..2464251 F 1 NC_006042.1 similar to uniprot|Q04660 Saccharomyces cerevisiae YMR049C ERB1 Protein required for maturation of the 25S and 5.8S ribosomal RNAs homologous to mammalian Bop1; uncharacterized protein 2464251 2894861 KLLA0_F26653g Kluyveromyces lactis uncharacterized protein XP_456266.1 2461876 D 28985 CDS KLLA0_F26675g 2894862 complement(2464378..2465277) F 1 NC_006042.1 some similarities with uniprot|Q04659 Saccharomyces cerevisiae YMR048W CSM3 Protein required for accurate chromosome segregation during meiosis; uncharacterized protein 2465277 2894862 KLLA0_F26675g Kluyveromyces lactis uncharacterized protein XP_456267.1 2464378 R 28985 CDS KLLA0_F26686g 9487486 2466251..2466490 F 1 NC_006042.1 some similarities with uniprot|Q3E826 Saccharomyces cerevisiae YKL068W-A Identified by homology to Ashbya gossypii; uncharacterized protein 2466490 9487486 KLLA0_F26686g Kluyveromyces lactis uncharacterized protein XP_002999439.1 2466251 D 28985 CDS KLLA0_F26697g 2894863 2467247..2470639 F 1 NC_006042.1 weakly similar to uniprot|Q02629 Saccharomyces cerevisiae YKL068W NUP100 Subunit of the nuclear pore complex (NPC); FG-nucleoporin NUP116 2470639 2894863 KLLA0_F26697g Kluyveromyces lactis FG-nucleoporin NUP116 XP_456268.1 2467247 D 28985 CDS KLLA0_F26763g 2894866 complement(2472250..2473575) F 1 NC_006042.1 weakly similar to uniprot|Q04213 Saccharomyces cerevisiae YMR044W IOC4 Member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing contains a PWWP motif; uncharacterized protein 2473575 2894866 KLLA0_F26763g Kluyveromyces lactis uncharacterized protein XP_456270.1 2472250 R 28985 CDS KLLA0_F26807g 2894843 complement(2474742..2475452) F 1 NC_006042.1 some similarities with uniprot|P11746 Saccharomyces cerevisiae YMR043W MCM1 Transcription factor involved in cell-type-specific transcription and pheromone response plays a central role in the formation of both repressor and activator complexes; uncharacterized protein 2475452 2894843 KLLA0_F26807g Kluyveromyces lactis uncharacterized protein XP_456272.1 2474742 R 28985 CDS KLLA0_F26818g 9487528 2477131..2477355 F 1 NC_006042.1 no similarity; uncharacterized protein 2477355 9487528 KLLA0_F26818g Kluyveromyces lactis uncharacterized protein XP_002999440.1 2477131 D 28985 CDS KLLA0_F26829g 2894844 2477782..2478405 F 1 NC_006042.1 similar to uniprot|P35723 Saccharomyces cerevisiae YKL065C YET1 Endoplasmic reticulum transmembrane protein homolog of human BAP31 protein; uncharacterized protein 2478405 2894844 KLLA0_F26829g Kluyveromyces lactis uncharacterized protein XP_456273.1 2477782 D 28985 CDS KLLA0_F26851g 2894845 complement(2478465..2479451) F 1 NC_006042.1 similar to uniprot|Q04212 Saccharomyces cerevisiae YMR041C Hypothetical ORF; D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA2 2479451 2894845 KLLA0_F26851g Kluyveromyces lactis D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA2 XP_456274.1 2478465 R 28985 CDS KLLA0_F26873g 2894846 2480009..2480743 F 1 NC_006042.1 some similarities with uniprot|P54000 Saccharomyces cerevisiae YMR039C SUB1 Suppressor of TFIIB mutations transcriptional coactivator; chromatin-binding transcription coactivator SUB1 2480743 2894846 KLLA0_F26873g Kluyveromyces lactis chromatin-binding transcription coactivator SUB1 XP_456275.1 2480009 D 28985 CDS KLLA0_F26895g 2894847 2481281..2484169 F 1 NC_006042.1 similar to uniprot|P35724 Saccharomyces cerevisiae YKL064W; uncharacterized protein 2484169 2894847 KLLA0_F26895g Kluyveromyces lactis uncharacterized protein XP_456276.1 2481281 D 28985 CDS KLLA0_F26917g 2894848 2484542..2485279 F 1 NC_006042.1 similar to uniprot|P40202 Saccharomyces cerevisiae YMR038C CCS1 Copper chaperone for superoxide dismutase Sod1p involved in oxidative stress protection Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; copper chaperone CCS1 2485279 2894848 KLLA0_F26917g Kluyveromyces lactis copper chaperone CCS1 XP_456277.1 2484542 D 28985 CDS KLLA0_F26939g 2894849 complement(2485499..2486092) F 1 NC_006042.1 similar to uniprot|P35725 Saccharomyces cerevisiae YKL063C Hypothetical ORF; uncharacterized protein 2486092 2894849 KLLA0_F26939g Kluyveromyces lactis uncharacterized protein XP_456278.1 2485499 R 28985 CDS KLLA0_F26961g 2894850 2486804..2488888 F 1 NC_006042.1 weakly similar to uniprot|P33748 Saccharomyces cerevisiae YMR037C MSN2 Transcriptional activator related to Msn4p activated in stress conditions which results in translocation from the cytoplasm to the nucleus binds DNA at stress response elements of responsive genes inducing gene expression; uncharacterized protein 2488888 2894850 KLLA0_F26961g Kluyveromyces lactis uncharacterized protein XP_456279.1 2486804 D 28985 CDS KLLA0_F26983g 2894851 2489326..2490729 F 1 NC_006042.1 some similarities with uniprot|P32801 Saccharomyces cerevisiae YKL048C ELM1 Serine/threonine protein kinase that regulates cellular morphogenesis septin behavior and cytokinesis required for the regulation of other kinases forms part of the bud neck ring; serine/threonine protein kinase ELM1 2490729 2894851 KLLA0_F26983g Kluyveromyces lactis serine/threonine protein kinase ELM1 XP_456280.1 2489326 D 28985 CDS KLLA0_F27005g 2894891 2491505..2493124 F 1 NC_006042.1 some similarities with uniprot|P23748 Saccharomyces cerevisiae YMR036C MIH1 Protein tyrosine phosphatase involved in cell cycle control regulates the phosphorylation state of Cdc28p homolog of S. pombe cdc25; uncharacterized protein 2493124 2894891 KLLA0_F27005g Kluyveromyces lactis uncharacterized protein XP_456281.1 2491505 D 28985 CDS KLLA0_F27027g 2894892 complement(2493258..2493794) F 1 NC_006042.1 similar to uniprot|P46972 Saccharomyces cerevisiae YMR035W IMP2 mitochondrial peptidase; endopeptidase catalytic subunit 2493794 2894892 KLLA0_F27027g Kluyveromyces lactis endopeptidase catalytic subunit XP_456282.1 2493258 R 28985 CDS KLLA0_F27049g 2894893 2495105..2496457 F 1 NC_006042.1 similar to uniprot|Q05131 Saccharomyces cerevisiae YMR034C Hypothetical ORF; uncharacterized protein 2496457 2894893 KLLA0_F27049g Kluyveromyces lactis uncharacterized protein XP_456283.1 2495105 D 28985 CDS KLLA0_F27071g 2894894 complement(2496781..2499894) F 1 NC_006042.1 similar to uniprot|Q12496 Saccharomyces cerevisiae YOL098C Hypothetical ORF; uncharacterized protein 2499894 2894894 KLLA0_F27071g Kluyveromyces lactis uncharacterized protein XP_456284.1 2496781 R 28985 CDS KLLA0_F27093g 2894895 2501049..2502740 F 1 NC_006042.1 similar to uniprot|P43548 Saccharomyces cerevisiae YFL055W AGP3 Low-affinity amino acid permease may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions transcription is induced under conditions of sulfur limitation; uncharacterized protein 2502740 2894895 KLLA0_F27093g Kluyveromyces lactis uncharacterized protein XP_456285.1 2501049 D 28985 CDS KLLA0_F27115g 2894896 complement(2502893..2504674) F 1 NC_006042.1 weakly similar to uniprot|Q12089 Saccharomyces cerevisiae YPL005W AEP3 Peripheral mitochondrial inner membrane protein located on the matrix face of the membrane stabilizes the bicistronic AAP1-ATP6 mRNA encoding subunits 6 and 8 of the ATP synthase complex; uncharacterized protein 2504674 2894896 KLLA0_F27115g Kluyveromyces lactis uncharacterized protein XP_456286.1 2502893 R 28985 CDS KLLA0_F27137g 2894897 complement(2505026..2508559) F 1 NC_006042.1 similar to uniprot|Q12200 Saccharomyces cerevisiae YPL006W NCR1 Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway involved in sphingolipid metabolism glycoprotein homologous to human Niemann Pick C1 (NPC) protein; sphingolipid transporter 2508559 2894897 KLLA0_F27137g Kluyveromyces lactis sphingolipid transporter XP_456287.1 2505026 R 28985 CDS KLLA0_F27159g 2894898 2508838..2510568 F 1 NC_006042.1 similar to uniprot|Q12308 Saccharomyces cerevisiae YPL007C TFC8 One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC) part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes linker between TauB and TauA domains human homolog is TFIIIC-90; transcription factor TFIIIC subunit TFC8 2510568 2894898 KLLA0_F27159g Kluyveromyces lactis transcription factor TFIIIC subunit TFC8 XP_456288.1 2508838 D 28985 CDS KLLA0_F27181g 2894899 complement(2510636..2513059) F 1 NC_006042.1 similar to uniprot|P22516 Saccharomyces cerevisiae YPL008W; DNA helicase 2513059 2894899 KLLA0_F27181g Kluyveromyces lactis DNA helicase XP_456289.1 2510636 R 28985 CDS KLLA0_F27203g 2894900 2514694..2515656 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 2515656 2894900 KLLA0_F27203g Kluyveromyces lactis uncharacterized protein XP_456290.1 2514694 D 28985 CDS KLLA0_F27225g 2894901 2517770..2519170 F 1 NC_006042.1 some similarities with uniprot|Q02606 Saccharomyces cerevisiae YPL014W Hypothetical ORF; uncharacterized protein 2519170 2894901 KLLA0_F27225g Kluyveromyces lactis uncharacterized protein XP_456291.1 2517770 D 28985 CDS KLLA0_F27247g 2894902 complement(2519696..2520058) F 1 NC_006042.1 highly similar to uniprot|Q02608 Saccharomyces cerevisiae YPL013C MRPS16 Mitochondrial ribosomal protein of the small subunit; mitochondrial 37S ribosomal protein bS16m 2520058 2894902 KLLA0_F27247g Kluyveromyces lactis mitochondrial 37S ribosomal protein bS16m XP_456292.1 2519696 R 28985 CDS KLLA0_F27269g 2894903 2520782..2524432 F 1 NC_006042.1 similar to uniprot|Q7LH12 Saccharomyces cerevisiae YPL012W RRP12 Protein required for normal pre-rRNA Processing member of a group of seven genes whose expression is repressed during growth on glucose before and during the diauxic shift; mRNA-binding protein RRP12 2524432 2894903 KLLA0_F27269g Kluyveromyces lactis mRNA-binding protein RRP12 XP_456293.1 2520782 D 28985 CDS KLLA0_F27291g 2894904 complement(2524625..2525674) F 1 NC_006042.1 similar to uniprot|Q12297 Saccharomyces cerevisiae YPL011C TAF3 TFIID subunit (47 kDa) involved in promoter binding and RNA polymerase II transcription initiation; uncharacterized protein 2525674 2894904 KLLA0_F27291g Kluyveromyces lactis uncharacterized protein XP_456294.1 2524625 R 28985 CDS KLLA0_F27313g 2894802 2526333..2526902 F 1 NC_006042.1 similar to uniprot|P53600 Saccharomyces cerevisiae YPL010W RET3 Zeta subunit of the coatomer complex (COPI) which coats Golgi-derived transport vesicles involved in retrograde transport between Golgi and ER; coatomer subunit zeta 2526902 2894802 KLLA0_F27313g Kluyveromyces lactis coatomer subunit zeta XP_456295.1 2526333 D 28985 CDS KLLA0_F27335g 2894803 complement(2527145..2530228) F 1 NC_006042.1 similar to uniprot|Q12532 Saccharomyces cerevisiae YPL009C Hypothetical ORF; uncharacterized protein 2530228 2894803 KLLA0_F27335g Kluyveromyces lactis uncharacterized protein XP_456296.1 2527145 R 28985 CDS KLLA0_F27357g 2894804 2530948..2533560 F 1 NC_006042.1 similar to uniprot|P25644 Saccharomyces cerevisiae YCR077C PAT1 Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor also required for faithful chromosome transmission maintenance of rDNA locus stability and protection of mRNA 3'-UTRs from trimming functionally linked to Pab1p; uncharacterized protein 2533560 2894804 KLLA0_F27357g Kluyveromyces lactis uncharacterized protein XP_456297.1 2530948 D 28985 CDS KLLA0_F27379g 2894805 2534020..2534913 F 1 NC_006042.1 weakly similar to uniprot|P25659 Saccharomyces cerevisiae YCR076C; uncharacterized protein 2534913 2894805 KLLA0_F27379g Kluyveromyces lactis uncharacterized protein XP_456298.1 2534020 D 28985 CDS KLLA0_F27390g 9487374 complement(2535052..2535300) F 1 NC_006042.1 similar to uniprot|Q3E830 Saccharomyces cerevisiae YCR075W-A Identified by homology to Ashbya gossypii; uncharacterized protein 2535300 9487374 KLLA0_F27390g Kluyveromyces lactis uncharacterized protein XP_002999441.1 2535052 R 28985 CDS KLLA0_F27401g 2894806 2535549..2537219 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 2537219 2894806 KLLA0_F27401g Kluyveromyces lactis uncharacterized protein XP_456299.1 2535549 D 28985 CDS KLLA0_F27423g 2894807 complement(2537353..2538891) F 1 NC_006042.1 some similarities with uniprot|P40530 Saccharomyces cerevisiae YIL042C Hypothetical ORF; uncharacterized protein 2538891 2894807 KLLA0_F27423g Kluyveromyces lactis uncharacterized protein XP_456300.1 2537353 R 28985 CDS KLLA0_F27445g 2894808 2539961..2540713 F 1 NC_006042.1 similar to uniprot|P17261 Saccharomyces cerevisiae YCR075C; cystinosin-like protein ERS1 2540713 2894808 KLLA0_F27445g Kluyveromyces lactis cystinosin-like protein ERS1 XP_456301.1 2539961 D 28985 CDS KLLA0_F27467g 2894809 complement(2541110..2543644) F 1 NC_006042.1 similar to uniprot|P40528 Saccharomyces cerevisiae YIL047C SYG1 Protein for which truncation and overexpression can suppress lethality of G-alpha protein deficiency plasma membrane protein; uncharacterized protein 2543644 2894809 KLLA0_F27467g Kluyveromyces lactis uncharacterized protein XP_456302.1 2541110 R 28985 CDS KLLA0_F27489g 2894810 2544518..2545411 F 1 NC_006042.1 highly similar to uniprot|P00498 Saccharomyces cerevisiae YER055C HIS1 ATP phosphoribosyltransferase a hexameric enzyme catalyzes the first step in histidine biosynthesis mutations cause histidine auxotrophy and sensitivity to Cu Co and Ni salts transcription is regulated by general amino acid control; ATP phosphoribosyltransferase 2545411 2894810 KLLA0_F27489g Kluyveromyces lactis ATP phosphoribosyltransferase XP_456303.1 2544518 D 28985 CDS KLLA0_F27511g 2894811 2546533..2548404 F 1 NC_006042.1 similar to uniprot|P39014 Saccharomyces cerevisiae YIL046W MET30 F-box protein containing five copies of the WD40 motif controls cell cycle function sulfur metabolism and methionine biosynthesis as part of the ubiquitin ligase complex interacts with and regulates Met4p localizes within the nucleus; ubiquitin-binding SDF ubiquitin ligase complex subunit MET30 2548404 2894811 KLLA0_F27511g Kluyveromyces lactis ubiquitin-binding SDF ubiquitin ligase complex subunit MET30 XP_456304.1 2546533 D 28985 CDS KLLA0_F27533g 2894812 2549457..2550953 F 1 NC_006042.1 weakly similar to uniprot|P40036 Saccharomyces cerevisiae YER054C GIP2 Putative regulatory subunit of the protein phosphatase Glc7p proposed to be involved in glycogen metabolism contains a conserved motif (GVNK motif) that is also found in Gac1p Pig1p and Pig2p; uncharacterized protein 2550953 2894812 KLLA0_F27533g Kluyveromyces lactis uncharacterized protein XP_456305.1 2549457 D 28985 CDS KLLA0_F27555g 2894813 complement(2554571..2555410) F 1 NC_006042.1 similar to uniprot|P40529 Saccharomyces cerevisiae YIL044C AGE2 ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector ARF GAP with effector function(s); GTPase-activating protein AGE2 2555410 2894813 KLLA0_F27555g Kluyveromyces lactis GTPase-activating protein AGE2 XP_456306.1 2554571 R 28985 CDS KLLA0_F27577g 2894814 2556662..2557180 F 1 NC_006042.1 some similarities with uniprot|P40312 Saccharomyces cerevisiae YNL111C CYB5 Cytochrome b5; uncharacterized protein 2557180 2894814 KLLA0_F27577g Kluyveromyces lactis uncharacterized protein XP_456307.1 2556662 D 28985 CDS KLLA0_F27599g 2894815 2558178..2559746 F 1 NC_006042.1 highly similar to uniprot|P10869 Saccharomyces cerevisiae YER052C HOM3 Aspartate kinase (L-aspartate 4-P-transferase) cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis expression regulated by Gcn4p and the general control of amino acid synthesis; aspartate kinase 2559746 2894815 KLLA0_F27599g Kluyveromyces lactis aspartate kinase XP_456308.1 2558178 D 28985 CDS KLLA0_F27621g 2894868 complement(2560055..2560900) F 1 NC_006042.1 similar to uniprot|P38626 Saccharomyces cerevisiae YIL043C CBR1 cytochrome b reductase; cytochrome-b5 reductase 2560900 2894868 KLLA0_F27621g Kluyveromyces lactis cytochrome-b5 reductase XP_456309.1 2560055 R 28985 CDS KLLA0_F27643g 2894869 complement(2561213..2562649) F 1 NC_006042.1 similar to uniprot|P40034 Saccharomyces cerevisiae YER051W Hypothetical ORF; [Histone H3]-lysine-36 demethylase 2562649 2894869 KLLA0_F27643g Kluyveromyces lactis [Histone H3]-lysine-36 demethylase XP_456310.1 2561213 R 28985 CDS KLLA0_F27665g 2894870 2563022..2566156 F 1 NC_006042.1 some similarities with uniprot|P40537 Saccharomyces cerevisiae YIL031W ULP2 Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins; SUMO protease ULP2 2566156 2894870 KLLA0_F27665g Kluyveromyces lactis SUMO protease ULP2 XP_456311.1 2563022 D 28985 CDS KLLA0_F27687g 2894871 complement(2566290..2569061) F 1 NC_006042.1 some similarities with uniprot|P40318 Saccharomyces cerevisiae YIL030C SSM4 Protein involved in mRNA turnover integral nuclear membrane protein; E3 ubiquitin-protein ligase SSM4 2569061 2894871 KLLA0_F27687g Kluyveromyces lactis E3 ubiquitin-protein ligase SSM4 XP_456312.1 2566290 R 28985 CDS KLLA0_F27709g 2894872 complement(2569570..2570445) F 1 NC_006042.1 weakly similar to with YIL030C uniprot|P40318 Saccharomyces cerevisiae YIL030C SSM4 Protein involved in mRNA turnover integral nuclear membrane protein; uncharacterized protein 2570445 2894872 KLLA0_F27709g Kluyveromyces lactis uncharacterized protein XP_456313.1 2569570 R 28985 CDS KLLA0_F27753g 2894874 2571155..2571496 F 1 NC_006042.1 weakly similar to uniprot|P14724 Saccharomyces cerevisiae YFR036W CDC26 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); uncharacterized protein 2571496 2894874 KLLA0_F27753g Kluyveromyces lactis uncharacterized protein XP_456314.1 2571155 D 28985 CDS KLLA0_F27775g 2894875 complement(2571644..2572054) F 1 NC_006042.1 similar to uniprot|P40540 Saccharomyces cerevisiae YIL027C KRE27 Protein of unknown function null mutant shows K1 killer toxin resistance; uncharacterized protein 2572054 2894875 KLLA0_F27775g Kluyveromyces lactis uncharacterized protein XP_456315.1 2571644 R 28985 CDS KLLA0_F27797g 2894876 complement(2572415..2575720) F 1 NC_006042.1 similar to uniprot|P40541 Saccharomyces cerevisiae YIL026C IRR1 Subunit of the cohesin complex which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms essential for viability; uncharacterized protein 2575720 2894876 KLLA0_F27797g Kluyveromyces lactis uncharacterized protein XP_456316.1 2572415 R 28985 CDS KLLA0_F27819g 2895042 complement(2576382..2577056) F 1 NC_006042.1 similar to uniprot|P40543 Saccharomyces cerevisiae YIL024C Hypothetical ORF; uncharacterized protein 2577056 2895042 KLLA0_F27819g Kluyveromyces lactis uncharacterized protein XP_456317.1 2576382 R 28985 CDS KLLA0_F27841g 2895043 2578531..2579112 F 1 NC_006042.1 no similarity; uncharacterized protein 2579112 2895043 KLLA0_F27841g Kluyveromyces lactis uncharacterized protein XP_456318.1 2578531 D 28985 CDS KLLA0_F27863g 2895044 complement(2579510..2580241) F 1 NC_006042.1 some similarities with uniprot|P38838 Saccharomyces cerevisiae YHR134W WSS1 weak suppressor of smt3; metalloendopeptidase WSS1 2580241 2895044 KLLA0_F27863g Kluyveromyces lactis metalloendopeptidase WSS1 XP_456319.1 2579510 R 28985 CDS KLLA0_F27885g 2895045 2580668..2581438 F 1 NC_006042.1 similar to uniprot|P53898 Saccharomyces cerevisiae YNL156C NSG2 Protein of unknown function potential homolog of mammalian Insig 1; uncharacterized protein 2581438 2895045 KLLA0_F27885g Kluyveromyces lactis uncharacterized protein XP_456320.1 2580668 D 28985 CDS KLLA0_F27907g 2895046 complement(2581760..2582212) F 1 NC_006042.1 highly similar to uniprot|Q9P305 Saccharomyces cerevisiae YHR132W-A Hypothetical ORF; uncharacterized protein 2582212 2895046 KLLA0_F27907g Kluyveromyces lactis uncharacterized protein XP_456321.1 2581760 R 28985 CDS KLLA0_F27929g 2895047 2583179..2584507 F 1 NC_006042.1 similar to uniprot|P38836 Saccharomyces cerevisiae YHR132C; uncharacterized protein 2584507 2895047 KLLA0_F27929g Kluyveromyces lactis uncharacterized protein XP_456322.1 2583179 D 28985 CDS KLLA0_F27951g 2895048 complement(2584589..2585161) F 1 NC_006042.1 weakly similar to uniprot|P53896 Saccharomyces cerevisiae YNL158W Essential protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; uncharacterized protein 2585161 2895048 KLLA0_F27951g Kluyveromyces lactis uncharacterized protein XP_456323.1 2584589 R 28985 CDS KLLA0_F27973g 2895049 2585445..2586146 F 1 NC_006042.1 some similarities with uniprot|P53895 Saccharomyces cerevisiae YNL159C ASI2 Predicted membrane protein; uncharacterized protein 2586146 2895049 KLLA0_F27973g Kluyveromyces lactis uncharacterized protein XP_456324.1 2585445 D 28985 CDS KLLA0_F27995g 2895050 2586722..2587954 F 1 NC_006042.1 conserved hypothetical protein; uncharacterized protein 2587954 2895050 KLLA0_F27995g Kluyveromyces lactis uncharacterized protein XP_456325.1 2586722 D 28985 CDS KLLA0_F28017g 2895051 2588273..2589466 F 1 NC_006042.1 similar to uniprot|Q6B1B1 Saccharomyces cerevisiae YPL060W LPE10 Mitochondrial inner membrane magnesium transporter involved in maintenance of magnesium concentrations inside mitochondria indirectly affects splicing of group II introns functionally and structurally related to Mrs2p; uncharacterized protein 2589466 2895051 KLLA0_F28017g Kluyveromyces lactis uncharacterized protein XP_456326.1 2588273 D 28985 CDS KLLA0_F28039g 2895052 2590003..2591325 F 1 NC_006042.1 similar to uniprot|P38310 Saccharomyces cerevisiae YBR207W FTH1 Putative high affinity iron transporter involved in transport of intravacuolar stores of iron forms complex with Fet5p expression is regulated by iron proposed to play indirect role in endocytosis; uncharacterized protein 2591325 2895052 KLLA0_F28039g Kluyveromyces lactis uncharacterized protein XP_456327.1 2590003 D 28985 CDS KLLA0_F28083g 2895054 complement(2594274..2596370) F 1 NC_006042.1 similar to uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane urea transporter expression is highly sensitive to nitrogen catabolite repression and induced by allophanate the last intermediate of the allantoin degradative pathway; uncharacterized protein 2596370 2895054 KLLA0_F28083g Kluyveromyces lactis uncharacterized protein XP_456328.1 2594274 R 28985 CDS KLLA0_F28105g 2895055 complement(2599341..2599682) F 1 NC_006042.1 no similarity; uncharacterized protein 2599682 2895055 KLLA0_F28105g Kluyveromyces lactis uncharacterized protein XP_456329.1 2599341 R 28985 CDS KllafMp01 2914050 2233..2397 NC_006077.1 1 NC_006077.1 ATPase complex subunit 9 2397 ATP9 2914050 ATP9 Kluyveromyces lactis ATPase complex subunit 9 YP_054496.1 2233 D 28985 CDS KllafMp02 2914051 complement(20667..21827) NC_006077.1 1 NC_006077.1 apocytochrome b 21827 CYTB 2914051 CYTB Kluyveromyces lactis apocytochrome b YP_054497.1 20667 R 28985 CDS KllafMp03 2914052 complement(25792..26562) NC_006077.1 1 NC_006077.1 ATPase complex subunit 6 26562 ATP6 2914052 ATP6 Kluyveromyces lactis ATPase complex subunit 6 YP_054498.1 25792 R 28985 CDS KllafMp04 2914080 complement(26986..27132) NC_006077.1 1 NC_006077.1 ATPase complex subunit 8 27132 ATP8 2914080 ATP8 Kluyveromyces lactis ATPase complex subunit 8 YP_054499.1 26986 R 28985 CDS KllafMp05 2914076 complement(join(27490..27987,29626..29761,31223..31484,33025..33733)) NC_006077.1 1 NC_006077.1 cytochrome c oxidase subunit 1 33733 COX1 2914076 COX1 Kluyveromyces lactis cytochrome c oxidase subunit 1 YP_054500.1 27490 R 28985 CDS KllafMp05 2914076 complement(28432..29622) NC_006077.1 1 NC_006077.1 contains 2 LAGLIDADG motifs; two GC-rich clusters; COX1 intron 3 ORF 29622 COX1 2914076 COX1 Kluyveromyces lactis COX1 intron 3 ORF YP_054501.1 28432 R 28985 CDS KllafMp06 2914081 complement(34936..35706) NC_006077.1 1 NC_006077.1 cytochrome c oxidase subunit 2 35706 COX2 2914081 COX2 Kluyveromyces lactis cytochrome c oxidase subunit 2 YP_054502.1 34936 R 28985 CDS KllafMp07 2914075 complement(36639..37805) NC_006077.1 1 NC_006077.1 putative start codon due to presence of multiple methionines; similar to Saccharomyces cerevisiae ribosomal small subunit protein; contains a palindromic GC cluster which does not interrupt the open reading frame; ribosomal small subunit protein 37805 VAR1 2914075 VAR1 Kluyveromyces lactis ribosomal small subunit protein YP_054503.1 36639 R 28985 CDS KllafMp08 2914070 38539..39348 NC_006077.1 1 NC_006077.1 cytochrome c oxidase subunit 3 39348 COX3 2914070 COX3 Kluyveromyces lactis cytochrome c oxidase subunit 3 YP_054504.1 38539 D 28985 CDS