-- dump date 20140619_102645
-- class Genbank::misc_feature
-- table misc_feature_note
-- id note
526225000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638
526225000002 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
526225000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526225000004 Walker A motif; other site
526225000005 ATP binding site [chemical binding]; other site
526225000006 Walker B motif; other site
526225000007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
526225000008 arginine finger; other site
526225000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
526225000010 DnaA box-binding interface [nucleotide binding]; other site
526225000011 DNA polymerase III subunit beta; Validated; Region: PRK07761
526225000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
526225000013 putative DNA binding surface [nucleotide binding]; other site
526225000014 dimer interface [polypeptide binding]; other site
526225000015 beta-clamp/clamp loader binding surface; other site
526225000016 beta-clamp/translesion DNA polymerase binding surface; other site
526225000017 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
526225000018 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490
526225000019 recombination protein F; Reviewed; Region: recF; PRK00064
526225000020 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
526225000021 Walker A/P-loop; other site
526225000022 ATP binding site [chemical binding]; other site
526225000023 Q-loop/lid; other site
526225000024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225000025 ABC transporter signature motif; other site
526225000026 Walker B; other site
526225000027 D-loop; other site
526225000028 H-loop/switch region; other site
526225000029 Protein of unknown function (DUF721); Region: DUF721; cl02324
526225000030 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
526225000031 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
526225000032 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225000033 Walker A/P-loop; other site
526225000034 ATP binding site [chemical binding]; other site
526225000035 Q-loop/lid; other site
526225000036 ABC transporter signature motif; other site
526225000037 Walker B; other site
526225000038 D-loop; other site
526225000039 H-loop/switch region; other site
526225000040 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
526225000041 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
526225000042 putative NAD(P) binding site [chemical binding]; other site
526225000043 putative active site [active]
526225000044 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
526225000045 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
526225000046 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225000047 ATP binding site [chemical binding]; other site
526225000048 Mg2+ binding site [ion binding]; other site
526225000049 G-X-G motif; other site
526225000050 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
526225000051 anchoring element; other site
526225000052 dimer interface [polypeptide binding]; other site
526225000053 ATP binding site [chemical binding]; other site
526225000054 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
526225000055 active site
526225000056 putative metal-binding site [ion binding]; other site
526225000057 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
526225000058 DNA gyrase subunit A; Validated; Region: PRK05560
526225000059 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
526225000060 CAP-like domain; other site
526225000061 active site
526225000062 primary dimer interface [polypeptide binding]; other site
526225000063 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
526225000064 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
526225000065 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
526225000066 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
526225000067 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
526225000068 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
526225000069 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
526225000070 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
526225000071 Helix-turn-helix domain; Region: HTH_17; cl17695
526225000072 TrwC relaxase; Region: TrwC; pfam08751
526225000073 AAA domain; Region: AAA_30; pfam13604
526225000074 Family description; Region: UvrD_C_2; pfam13538
526225000075 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526225000076 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225000077 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
526225000078 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
526225000079 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
526225000080 putative NAD(P) binding site [chemical binding]; other site
526225000081 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
526225000082 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
526225000083 Walker A/P-loop; other site
526225000084 ATP binding site [chemical binding]; other site
526225000085 Q-loop/lid; other site
526225000086 ABC transporter signature motif; other site
526225000087 Walker B; other site
526225000088 D-loop; other site
526225000089 H-loop/switch region; other site
526225000090 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
526225000091 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
526225000092 Coenzyme A binding pocket [chemical binding]; other site
526225000093 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
526225000094 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
526225000095 tandem repeat interface [polypeptide binding]; other site
526225000096 oligomer interface [polypeptide binding]; other site
526225000097 active site residues [active]
526225000098 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652
526225000099 active site
526225000100 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504
526225000101 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
526225000102 dimer interface [polypeptide binding]; other site
526225000103 active site
526225000104 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781
526225000105 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
526225000106 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
526225000107 Glutamine amidotransferase class-I; Region: GATase; pfam00117
526225000108 glutamine binding [chemical binding]; other site
526225000109 catalytic triad [active]
526225000110 Protein Kinases, catalytic domain; Region: PKc_like; cl09925
526225000111 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526225000112 active site
526225000113 ATP binding site [chemical binding]; other site
526225000114 substrate binding site [chemical binding]; other site
526225000115 activation loop (A-loop); other site
526225000116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
526225000117 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
526225000118 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
526225000119 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
526225000120 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
526225000121 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526225000122 Catalytic domain of Protein Kinases; Region: PKc; cd00180
526225000123 active site
526225000124 ATP binding site [chemical binding]; other site
526225000125 substrate binding site [chemical binding]; other site
526225000126 activation loop (A-loop); other site
526225000127 PASTA domain; Region: PASTA; smart00740
526225000128 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
526225000129 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
526225000130 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
526225000131 active site
526225000132 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
526225000133 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
526225000134 phosphopeptide binding site; other site
526225000135 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
526225000136 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
526225000137 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
526225000138 phosphopeptide binding site; other site
526225000139 SnoaL-like domain; Region: SnoaL_2; pfam12680
526225000140 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
526225000141 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
526225000142 active site
526225000143 catalytic residues [active]
526225000144 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
526225000145 MOSC domain; Region: MOSC; pfam03473
526225000146 S4 domain; Region: S4_2; pfam13275
526225000147 aminotransferase; Validated; Region: PRK07777
526225000148 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
526225000149 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225000150 homodimer interface [polypeptide binding]; other site
526225000151 catalytic residue [active]
526225000152 C-N hydrolase family amidase; Provisional; Region: PRK10438
526225000153 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
526225000154 active site
526225000155 catalytic triad [active]
526225000156 dimer interface [polypeptide binding]; other site
526225000157 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
526225000158 active site
526225000159 PRC-barrel domain; Region: PRC; pfam05239
526225000160 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
526225000161 putative active site; other site
526225000162 putative metal binding residues [ion binding]; other site
526225000163 signature motif; other site
526225000164 putative triphosphate binding site [ion binding]; other site
526225000165 CHAD domain; Region: CHAD; pfam05235
526225000166 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
526225000167 putative active site [active]
526225000168 putative metal binding site [ion binding]; other site
526225000169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225000170 Transcriptional regulators [Transcription]; Region: PhnF; COG2188
526225000171 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526225000172 DNA-binding site [nucleotide binding]; DNA binding site
526225000173 UTRA domain; Region: UTRA; pfam07702
526225000174 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
526225000175 hydrophobic ligand binding site; other site
526225000176 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
526225000177 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
526225000178 enoyl-CoA hydratase; Provisional; Region: PRK08140
526225000179 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526225000180 substrate binding site [chemical binding]; other site
526225000181 oxyanion hole (OAH) forming residues; other site
526225000182 trimer interface [polypeptide binding]; other site
526225000183 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526225000184 Catalytic domain of Protein Kinases; Region: PKc; cd00180
526225000185 active site
526225000186 ATP binding site [chemical binding]; other site
526225000187 substrate binding site [chemical binding]; other site
526225000188 activation loop (A-loop); other site
526225000189 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526225000190 Catalytic domain of Protein Kinases; Region: PKc; cd00180
526225000191 active site
526225000192 ATP binding site [chemical binding]; other site
526225000193 substrate binding site [chemical binding]; other site
526225000194 activation loop (A-loop); other site
526225000195 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
526225000196 competence damage-inducible protein A; Provisional; Region: PRK00549
526225000197 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
526225000198 MPT binding site; other site
526225000199 Competence-damaged protein; Region: CinA; pfam02464
526225000200 Cupin domain; Region: Cupin_2; pfam07883
526225000201 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
526225000202 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
526225000203 Domain of unknown function (DUF222); Region: DUF222; pfam02720
526225000204 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
526225000205 active site
526225000206 PAS fold; Region: PAS_4; pfam08448
526225000207 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
526225000208 putative active site [active]
526225000209 heme pocket [chemical binding]; other site
526225000210 PAS fold; Region: PAS_4; pfam08448
526225000211 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
526225000212 metal binding site [ion binding]; metal-binding site
526225000213 active site
526225000214 I-site; other site
526225000215 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
526225000216 LabA_like proteins; Region: LabA_like; cd06167
526225000217 putative metal binding site [ion binding]; other site
526225000218 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140
526225000219 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
526225000220 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
526225000221 putative active site [active]
526225000222 putative active site [active]
526225000223 catalytic site [active]
526225000224 catalytic site [active]
526225000225 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143
526225000226 putative active site [active]
526225000227 catalytic site [active]
526225000228 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
526225000229 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
526225000230 PAS domain; Region: PAS; smart00091
526225000231 PAS domain S-box; Region: sensory_box; TIGR00229
526225000232 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
526225000233 putative active site [active]
526225000234 heme pocket [chemical binding]; other site
526225000235 GAF domain; Region: GAF_2; pfam13185
526225000236 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
526225000237 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199
526225000238 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
526225000239 metal binding site [ion binding]; metal-binding site
526225000240 active site
526225000241 I-site; other site
526225000242 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
526225000243 PilZ domain; Region: PilZ; pfam07238
526225000244 PilZ domain; Region: PilZ; pfam07238
526225000245 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
526225000246 G1 box; other site
526225000247 GTP/Mg2+ binding site [chemical binding]; other site
526225000248 G2 box; other site
526225000249 Switch I region; other site
526225000250 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
526225000251 G1 box; other site
526225000252 GTP/Mg2+ binding site [chemical binding]; other site
526225000253 G2 box; other site
526225000254 Switch I region; other site
526225000255 G3 box; other site
526225000256 Switch II region; other site
526225000257 G4 box; other site
526225000258 G5 box; other site
526225000259 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
526225000260 GAF domain; Region: GAF; pfam01590
526225000261 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
526225000262 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
526225000263 active site
526225000264 amino acid transporter; Region: 2A0306; TIGR00909
526225000265 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
526225000266 PAS fold; Region: PAS_3; pfam08447
526225000267 putative active site [active]
526225000268 heme pocket [chemical binding]; other site
526225000269 PAS domain; Region: PAS; smart00091
526225000270 PAS fold; Region: PAS_4; pfam08448
526225000271 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
526225000272 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
526225000273 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
526225000274 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
526225000275 intersubunit interface [polypeptide binding]; other site
526225000276 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
526225000277 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
526225000278 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
526225000279 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
526225000280 active site
526225000281 thiamine phosphate binding site [chemical binding]; other site
526225000282 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
526225000283 ThiS interaction site; other site
526225000284 putative active site [active]
526225000285 tetramer interface [polypeptide binding]; other site
526225000286 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
526225000287 thiS-thiF/thiG interaction site; other site
526225000288 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
526225000289 hydroxyglutarate oxidase; Provisional; Region: PRK11728
526225000290 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
526225000291 Na binding site [ion binding]; other site
526225000292 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
526225000293 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
526225000294 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
526225000295 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
526225000296 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451
526225000297 Uncharacterized conserved protein [Function unknown]; Region: COG1656
526225000298 Protein of unknown function DUF82; Region: DUF82; pfam01927
526225000299 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348
526225000300 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526225000301 putative active site [active]
526225000302 putative metal binding site [ion binding]; other site
526225000303 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
526225000304 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
526225000305 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
526225000306 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288
526225000307 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
526225000308 catalytic site [active]
526225000309 methionine sulfoxide reductase A; Provisional; Region: PRK00058
526225000310 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
526225000311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225000312 S-adenosylmethionine binding site [chemical binding]; other site
526225000313 Methyltransferase domain; Region: Methyltransf_23; pfam13489
526225000314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225000315 S-adenosylmethionine binding site [chemical binding]; other site
526225000316 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
526225000317 dimerization interface [polypeptide binding]; other site
526225000318 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
526225000319 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
526225000320 dimer interface [polypeptide binding]; other site
526225000321 putative CheW interface [polypeptide binding]; other site
526225000322 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
526225000323 active site
526225000324 homotetramer interface [polypeptide binding]; other site
526225000325 putative OHCU decarboxylase; Provisional; Region: PRK13798
526225000326 GAF domain; Region: GAF_3; pfam13492
526225000327 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
526225000328 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
526225000329 dimer interface [polypeptide binding]; other site
526225000330 phosphorylation site [posttranslational modification]
526225000331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225000332 ATP binding site [chemical binding]; other site
526225000333 Mg2+ binding site [ion binding]; other site
526225000334 G-X-G motif; other site
526225000335 Response regulator receiver domain; Region: Response_reg; pfam00072
526225000336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225000337 active site
526225000338 phosphorylation site [posttranslational modification]
526225000339 intermolecular recognition site; other site
526225000340 dimerization interface [polypeptide binding]; other site
526225000341 PAS domain S-box; Region: sensory_box; TIGR00229
526225000342 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
526225000343 putative active site [active]
526225000344 heme pocket [chemical binding]; other site
526225000345 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
526225000346 GAF domain; Region: GAF_2; pfam13185
526225000347 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
526225000348 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
526225000349 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417
526225000350 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
526225000351 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526225000352 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526225000353 putative Zn2+ binding site [ion binding]; other site
526225000354 putative DNA binding site [nucleotide binding]; other site
526225000355 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
526225000356 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
526225000357 active site
526225000358 DNA binding site [nucleotide binding]
526225000359 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
526225000360 DNA binding site [nucleotide binding]
526225000361 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
526225000362 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
526225000363 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
526225000364 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
526225000365 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
526225000366 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
526225000367 FAD binding domain; Region: FAD_binding_4; pfam01565
526225000368 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
526225000369 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
526225000370 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
526225000371 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
526225000372 MarR family; Region: MarR; pfam01047
526225000373 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
526225000374 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
526225000375 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225000376 Walker A/P-loop; other site
526225000377 ATP binding site [chemical binding]; other site
526225000378 Q-loop/lid; other site
526225000379 ABC transporter signature motif; other site
526225000380 Walker B; other site
526225000381 D-loop; other site
526225000382 H-loop/switch region; other site
526225000383 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
526225000384 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
526225000385 active site
526225000386 catalytic site [active]
526225000387 RibD C-terminal domain; Region: RibD_C; cl17279
526225000388 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
526225000389 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
526225000390 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
526225000391 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254
526225000392 N-acetyl-D-glucosamine binding site [chemical binding]; other site
526225000393 catalytic residue [active]
526225000394 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
526225000395 active site
526225000396 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526225000397 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673
526225000398 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673
526225000399 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
526225000400 Cytochrome P450; Region: p450; cl12078
526225000401 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
526225000402 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
526225000403 hypothetical protein; Provisional; Region: PRK06184
526225000404 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
526225000405 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
526225000406 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
526225000407 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
526225000408 active site
526225000409 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
526225000410 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
526225000411 dimer interface [polypeptide binding]; other site
526225000412 active site
526225000413 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
526225000414 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
526225000415 N-terminal aromatase/cyclase domain of the multifunctional protein tetracenomycin (TcmN) and related domains; Region: TcmN_ARO-CYC_like; cd08860
526225000416 putative hydrophobic ligand binding site [chemical binding]; other site
526225000417 active site
526225000418 catalytic residues_2 [active]
526225000419 catalytic residues_1 [active]
526225000420 Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526225000421 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
526225000422 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
526225000423 ATP-grasp domain; Region: ATP-grasp_4; cl17255
526225000424 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
526225000425 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
526225000426 carboxyltransferase (CT) interaction site; other site
526225000427 biotinylation site [posttranslational modification]; other site
526225000428 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
526225000429 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
526225000430 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673
526225000431 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225000432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225000433 active site
526225000434 phosphorylation site [posttranslational modification]
526225000435 intermolecular recognition site; other site
526225000436 dimerization interface [polypeptide binding]; other site
526225000437 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225000438 DNA binding residues [nucleotide binding]
526225000439 dimerization interface [polypeptide binding]; other site
526225000440 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225000441 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225000442 DNA binding residues [nucleotide binding]
526225000443 dimerization interface [polypeptide binding]; other site
526225000444 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
526225000445 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
526225000446 FMN binding site [chemical binding]; other site
526225000447 active site
526225000448 substrate binding site [chemical binding]; other site
526225000449 catalytic residue [active]
526225000450 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526225000451 MarR family; Region: MarR; pfam01047
526225000452 PPOX class probable F420-dependent enzyme, MSMEG_5819 family; Region: PPOX_MSMEG_5819; TIGR04023
526225000453 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
526225000454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225000455 Walker A/P-loop; other site
526225000456 ATP binding site [chemical binding]; other site
526225000457 Q-loop/lid; other site
526225000458 ABC transporter signature motif; other site
526225000459 Walker B; other site
526225000460 D-loop; other site
526225000461 H-loop/switch region; other site
526225000462 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
526225000463 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
526225000464 Walker A/P-loop; other site
526225000465 ATP binding site [chemical binding]; other site
526225000466 Q-loop/lid; other site
526225000467 ABC transporter signature motif; other site
526225000468 Walker B; other site
526225000469 D-loop; other site
526225000470 H-loop/switch region; other site
526225000471 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
526225000472 Beta-lactamase; Region: Beta-lactamase; pfam00144
526225000473 short chain dehydrogenase; Provisional; Region: PRK06197
526225000474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225000475 NAD(P) binding site [chemical binding]; other site
526225000476 active site
526225000477 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
526225000478 putative hydrophobic ligand binding site [chemical binding]; other site
526225000479 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
526225000480 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
526225000481 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
526225000482 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
526225000483 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526225000484 catalytic loop [active]
526225000485 iron binding site [ion binding]; other site
526225000486 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799
526225000487 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
526225000488 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
526225000489 pyrimidine utilization transport protein G; Region: RutG; TIGR03616
526225000490 CoA-ligase; Region: Ligase_CoA; pfam00549
526225000491 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
526225000492 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
526225000493 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
526225000494 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
526225000495 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
526225000496 RNA binding surface [nucleotide binding]; other site
526225000497 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
526225000498 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819
526225000499 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
526225000500 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
526225000501 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
526225000502 dimer interface [polypeptide binding]; other site
526225000503 putative CheW interface [polypeptide binding]; other site
526225000504 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; pfam09663
526225000505 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
526225000506 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
526225000507 putative substrate binding site [chemical binding]; other site
526225000508 nucleotide binding site [chemical binding]; other site
526225000509 nucleotide binding site [chemical binding]; other site
526225000510 homodimer interface [polypeptide binding]; other site
526225000511 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
526225000512 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856
526225000513 active site
526225000514 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
526225000515 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526225000516 ATP binding site [chemical binding]; other site
526225000517 putative Mg++ binding site [ion binding]; other site
526225000518 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526225000519 nucleotide binding region [chemical binding]; other site
526225000520 ATP-binding site [chemical binding]; other site
526225000521 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145
526225000522 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
526225000523 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
526225000524 Walker A/P-loop; other site
526225000525 ATP binding site [chemical binding]; other site
526225000526 Q-loop/lid; other site
526225000527 ABC transporter signature motif; other site
526225000528 Walker B; other site
526225000529 D-loop; other site
526225000530 H-loop/switch region; other site
526225000531 Predicted transcriptional regulators [Transcription]; Region: COG1725
526225000532 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526225000533 DNA-binding site [nucleotide binding]; DNA binding site
526225000534 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
526225000535 alpha-gamma subunit interface [polypeptide binding]; other site
526225000536 beta-gamma subunit interface [polypeptide binding]; other site
526225000537 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
526225000538 gamma-beta subunit interface [polypeptide binding]; other site
526225000539 alpha-beta subunit interface [polypeptide binding]; other site
526225000540 urease subunit alpha; Reviewed; Region: ureC; PRK13206
526225000541 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
526225000542 subunit interactions [polypeptide binding]; other site
526225000543 active site
526225000544 flap region; other site
526225000545 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
526225000546 UreD urease accessory protein; Region: UreD; cl00530
526225000547 allantoicase; Provisional; Region: PRK13257
526225000548 Allantoicase repeat; Region: Allantoicase; pfam03561
526225000549 Allantoicase repeat; Region: Allantoicase; pfam03561
526225000550 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
526225000551 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
526225000552 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
526225000553 active site
526225000554 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
526225000555 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526225000556 catalytic residue [active]
526225000557 Anti-sigma-K factor rskA; Region: RskA; pfam10099
526225000558 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
526225000559 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526225000560 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526225000561 DNA binding residues [nucleotide binding]
526225000562 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
526225000563 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
526225000564 ergothioneine biosynthesis protein EgtC; Region: TIGR03442
526225000565 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
526225000566 putative active site [active]
526225000567 putative dimer interface [polypeptide binding]; other site
526225000568 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
526225000569 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
526225000570 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
526225000571 Domain of unknown function (DUF309); Region: DUF309; pfam03745
526225000572 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822
526225000573 putative hydrophobic ligand binding site [chemical binding]; other site
526225000574 Predicted transcriptional regulators [Transcription]; Region: COG1695
526225000575 Transcriptional regulator PadR-like family; Region: PadR; pfam03551
526225000576 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
526225000577 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
526225000578 Malic enzyme, N-terminal domain; Region: malic; pfam00390
526225000579 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
526225000580 putative NAD(P) binding site [chemical binding]; other site
526225000581 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
526225000582 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
526225000583 putative DNA binding site [nucleotide binding]; other site
526225000584 catalytic residue [active]
526225000585 putative H2TH interface [polypeptide binding]; other site
526225000586 putative catalytic residues [active]
526225000587 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
526225000588 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
526225000589 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
526225000590 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
526225000591 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
526225000592 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
526225000593 [2Fe-2S] cluster binding site [ion binding]; other site
526225000594 Protein of unknown function, DUF485; Region: DUF485; pfam04341
526225000595 Predicted symporter [General function prediction only]; Region: DhlC; COG4147
526225000596 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
526225000597 Na binding site [ion binding]; other site
526225000598 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
526225000599 dimanganese center [ion binding]; other site
526225000600 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
526225000601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225000602 ATP binding site [chemical binding]; other site
526225000603 Mg2+ binding site [ion binding]; other site
526225000604 G-X-G motif; other site
526225000605 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225000606 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225000607 DNA binding residues [nucleotide binding]
526225000608 dimerization interface [polypeptide binding]; other site
526225000609 Predicted membrane protein [Function unknown]; Region: COG3428
526225000610 Bacterial PH domain; Region: DUF304; pfam03703
526225000611 Bacterial PH domain; Region: DUF304; pfam03703
526225000612 Bacterial PH domain; Region: DUF304; cl01348
526225000613 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
526225000614 active site residue [active]
526225000615 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
526225000616 Predicted membrane protein [Function unknown]; Region: COG2246
526225000617 GtrA-like protein; Region: GtrA; pfam04138
526225000618 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526225000619 active site
526225000620 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
526225000621 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526225000622 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
526225000623 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
526225000624 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
526225000625 DXD motif; other site
526225000626 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
526225000627 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
526225000628 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
526225000629 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
526225000630 dimer interface [polypeptide binding]; other site
526225000631 acyl-activating enzyme (AAE) consensus motif; other site
526225000632 putative active site [active]
526225000633 AMP binding site [chemical binding]; other site
526225000634 putative CoA binding site [chemical binding]; other site
526225000635 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
526225000636 Cytochrome P450; Region: p450; cl12078
526225000637 SEC-C motif; Region: SEC-C; pfam02810
526225000638 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
526225000639 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
526225000640 putative ligand binding site [chemical binding]; other site
526225000641 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
526225000642 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
526225000643 Walker A/P-loop; other site
526225000644 ATP binding site [chemical binding]; other site
526225000645 Q-loop/lid; other site
526225000646 ABC transporter signature motif; other site
526225000647 Walker B; other site
526225000648 D-loop; other site
526225000649 H-loop/switch region; other site
526225000650 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
526225000651 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526225000652 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
526225000653 TM-ABC transporter signature motif; other site
526225000654 Transcriptional regulators [Transcription]; Region: PurR; COG1609
526225000655 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
526225000656 DNA binding site [nucleotide binding]
526225000657 domain linker motif; other site
526225000658 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
526225000659 ligand binding site [chemical binding]; other site
526225000660 dimerization interface (open form) [polypeptide binding]; other site
526225000661 dimerization interface (closed form) [polypeptide binding]; other site
526225000662 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778
526225000663 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
526225000664 putative N- and C-terminal domain interface [polypeptide binding]; other site
526225000665 putative active site [active]
526225000666 MgATP binding site [chemical binding]; other site
526225000667 catalytic site [active]
526225000668 metal binding site [ion binding]; metal-binding site
526225000669 putative carbohydrate binding site [chemical binding]; other site
526225000670 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557
526225000671 intersubunit interface [polypeptide binding]; other site
526225000672 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
526225000673 active site
526225000674 Zn2+ binding site [ion binding]; other site
526225000675 L-arabinose isomerase; Provisional; Region: PRK02929
526225000676 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
526225000677 hexamer (dimer of trimers) interface [polypeptide binding]; other site
526225000678 trimer interface [polypeptide binding]; other site
526225000679 substrate binding site [chemical binding]; other site
526225000680 Mn binding site [ion binding]; other site
526225000681 arginine deiminase; Provisional; Region: PRK01388
526225000682 gluconate 5-dehydrogenase; Provisional; Region: PRK08213
526225000683 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225000684 NAD(P) binding site [chemical binding]; other site
526225000685 active site
526225000686 FAD binding domain; Region: FAD_binding_4; pfam01565
526225000687 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
526225000688 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
526225000689 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
526225000690 Cysteine-rich domain; Region: CCG; pfam02754
526225000691 Cysteine-rich domain; Region: CCG; pfam02754
526225000692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225000693 S-adenosylmethionine binding site [chemical binding]; other site
526225000694 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
526225000695 MerR HTH family regulatory protein; Region: MerR_1; pfam13411
526225000696 DNA binding residues [nucleotide binding]
526225000697 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
526225000698 Protein of unknown function (DUF664); Region: DUF664; pfam04978
526225000699 DinB superfamily; Region: DinB_2; pfam12867
526225000700 haloalkane dehalogenase; Provisional; Region: PRK03592
526225000701 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
526225000702 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
526225000703 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
526225000704 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
526225000705 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
526225000706 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225000707 Walker A/P-loop; other site
526225000708 ATP binding site [chemical binding]; other site
526225000709 Q-loop/lid; other site
526225000710 ABC transporter signature motif; other site
526225000711 Walker B; other site
526225000712 D-loop; other site
526225000713 H-loop/switch region; other site
526225000714 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
526225000715 Predicted membrane protein [Function unknown]; Region: COG2119
526225000716 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
526225000717 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
526225000718 Major Facilitator Superfamily; Region: MFS_1; pfam07690
526225000719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225000720 Helix-turn-helix domain; Region: HTH_18; pfam12833
526225000721 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526225000722 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
526225000723 putative dimer interface [polypeptide binding]; other site
526225000724 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199
526225000725 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
526225000726 metal binding site [ion binding]; metal-binding site
526225000727 active site
526225000728 I-site; other site
526225000729 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
526225000730 AIR carboxylase; Region: AIRC; cl00310
526225000731 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199
526225000732 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
526225000733 metal binding site [ion binding]; metal-binding site
526225000734 active site
526225000735 I-site; other site
526225000736 prephenate dehydratase; Provisional; Region: PRK11898
526225000737 Prephenate dehydratase; Region: PDT; pfam00800
526225000738 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
526225000739 putative L-Phe binding site [chemical binding]; other site
526225000740 MMPL family; Region: MMPL; pfam03176
526225000741 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526225000742 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
526225000743 oligomerisation interface [polypeptide binding]; other site
526225000744 mobile loop; other site
526225000745 roof hairpin; other site
526225000746 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
526225000747 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
526225000748 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
526225000749 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
526225000750 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
526225000751 phosphate binding site [ion binding]; other site
526225000752 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
526225000753 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423
526225000754 DXD motif; other site
526225000755 HEAT repeats; Region: HEAT_2; pfam13646
526225000756 HEAT repeats; Region: HEAT_2; pfam13646
526225000757 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526225000758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225000759 active site
526225000760 phosphorylation site [posttranslational modification]
526225000761 intermolecular recognition site; other site
526225000762 dimerization interface [polypeptide binding]; other site
526225000763 CHASE3 domain; Region: CHASE3; pfam05227
526225000764 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
526225000765 phosphorylation site [posttranslational modification]
526225000766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225000767 ATP binding site [chemical binding]; other site
526225000768 Mg2+ binding site [ion binding]; other site
526225000769 G-X-G motif; other site
526225000770 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
526225000771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225000772 active site
526225000773 phosphorylation site [posttranslational modification]
526225000774 intermolecular recognition site; other site
526225000775 dimerization interface [polypeptide binding]; other site
526225000776 Response regulator receiver domain; Region: Response_reg; pfam00072
526225000777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225000778 active site
526225000779 phosphorylation site [posttranslational modification]
526225000780 intermolecular recognition site; other site
526225000781 dimerization interface [polypeptide binding]; other site
526225000782 seryl-tRNA synthetase; Provisional; Region: PRK05431
526225000783 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
526225000784 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
526225000785 dimer interface [polypeptide binding]; other site
526225000786 active site
526225000787 motif 1; other site
526225000788 motif 2; other site
526225000789 motif 3; other site
526225000790 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
526225000791 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
526225000792 active site
526225000793 motif I; other site
526225000794 motif II; other site
526225000795 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526225000796 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
526225000797 active site
526225000798 motif I; other site
526225000799 motif II; other site
526225000800 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526225000801 motif II; other site
526225000802 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
526225000803 Domain of unknown function (DUF336); Region: DUF336; pfam03928
526225000804 propanediol dehydratase small subunit; Provisional; Region: pduE; PRK15443
526225000805 propanediol dehydratase large subunit; Provisional; Region: pduC; PRK15444
526225000806 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
526225000807 alpha-alpha subunit/dimer interface [polypeptide binding]; other site
526225000808 alpha-beta subunit interface [polypeptide binding]; other site
526225000809 alpha-gamma subunit interface [polypeptide binding]; other site
526225000810 active site
526225000811 substrate and K+ binding site; other site
526225000812 K+ binding site [ion binding]; other site
526225000813 cobalamin binding site [chemical binding]; other site
526225000814 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
526225000815 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
526225000816 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
526225000817 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759
526225000818 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
526225000819 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
526225000820 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526225000821 catalytic residue [active]
526225000822 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
526225000823 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
526225000824 NAD(P) binding site [chemical binding]; other site
526225000825 Cupin; Region: Cupin_6; pfam12852
526225000826 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
526225000827 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526225000828 4-coumarate--CoA ligase; Region: PLN02246
526225000829 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904
526225000830 acyl-activating enzyme (AAE) consensus motif; other site
526225000831 active site
526225000832 putative CoA binding site [chemical binding]; other site
526225000833 AMP binding site [chemical binding]; other site
526225000834 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
526225000835 CoenzymeA binding site [chemical binding]; other site
526225000836 subunit interaction site [polypeptide binding]; other site
526225000837 PHB binding site; other site
526225000838 dihydropteroate synthase; Region: DHPS; TIGR01496
526225000839 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219
526225000840 substrate binding pocket [chemical binding]; other site
526225000841 dimer interface [polypeptide binding]; other site
526225000842 inhibitor binding site; inhibition site
526225000843 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
526225000844 putative active site [active]
526225000845 putative catalytic site [active]
526225000846 Beta-lactamase; Region: Beta-lactamase; pfam00144
526225000847 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
526225000848 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
526225000849 IHF dimer interface [polypeptide binding]; other site
526225000850 IHF - DNA interface [nucleotide binding]; other site
526225000851 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526225000852 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526225000853 active site
526225000854 catalytic tetrad [active]
526225000855 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
526225000856 Predicted membrane protein [Function unknown]; Region: COG2860
526225000857 UPF0126 domain; Region: UPF0126; pfam03458
526225000858 amidase; Provisional; Region: PRK07235
526225000859 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
526225000860 acyl-coenzyme A oxidase; Region: PLN02636
526225000861 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526225000862 active site
526225000863 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526225000864 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225000865 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
526225000866 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
526225000867 dimer interface [polypeptide binding]; other site
526225000868 active site
526225000869 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
526225000870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225000871 NAD(P) binding site [chemical binding]; other site
526225000872 active site
526225000873 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
526225000874 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
526225000875 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
526225000876 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
526225000877 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
526225000878 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
526225000879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526225000880 dimer interface [polypeptide binding]; other site
526225000881 conserved gate region; other site
526225000882 putative PBP binding loops; other site
526225000883 ABC-ATPase subunit interface; other site
526225000884 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
526225000885 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
526225000886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526225000887 putative PBP binding loops; other site
526225000888 dimer interface [polypeptide binding]; other site
526225000889 ABC-ATPase subunit interface; other site
526225000890 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
526225000891 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
526225000892 Walker A/P-loop; other site
526225000893 ATP binding site [chemical binding]; other site
526225000894 Q-loop/lid; other site
526225000895 ABC transporter signature motif; other site
526225000896 Walker B; other site
526225000897 D-loop; other site
526225000898 H-loop/switch region; other site
526225000899 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
526225000900 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
526225000901 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
526225000902 Walker A/P-loop; other site
526225000903 ATP binding site [chemical binding]; other site
526225000904 Q-loop/lid; other site
526225000905 ABC transporter signature motif; other site
526225000906 Walker B; other site
526225000907 D-loop; other site
526225000908 H-loop/switch region; other site
526225000909 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
526225000910 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668
526225000911 Methyltransferase domain; Region: Methyltransf_23; pfam13489
526225000912 Methyltransferase domain; Region: Methyltransf_12; pfam08242
526225000913 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
526225000914 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
526225000915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
526225000916 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
526225000917 Ligand Binding Site [chemical binding]; other site
526225000918 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
526225000919 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
526225000920 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
526225000921 putative phosphate binding site [ion binding]; other site
526225000922 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526225000923 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
526225000924 substrate binding site [chemical binding]; other site
526225000925 oxyanion hole (OAH) forming residues; other site
526225000926 trimer interface [polypeptide binding]; other site
526225000927 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526225000928 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225000929 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526225000930 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526225000931 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
526225000932 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
526225000933 putative ADP-binding pocket [chemical binding]; other site
526225000934 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526225000935 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
526225000936 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
526225000937 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
526225000938 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
526225000939 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
526225000940 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
526225000941 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
526225000942 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
526225000943 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
526225000944 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
526225000945 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
526225000946 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
526225000947 molybdopterin cofactor binding site; other site
526225000948 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
526225000949 4Fe-4S binding domain; Region: Fer4; cl02805
526225000950 Polysulphide reductase, NrfD; Region: NrfD; pfam03916
526225000951 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666
526225000952 classical (c) SDRs; Region: SDR_c; cd05233
526225000953 NAD(P) binding site [chemical binding]; other site
526225000954 active site
526225000955 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526225000956 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
526225000957 putative ADP-binding pocket [chemical binding]; other site
526225000958 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
526225000959 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526225000960 active site
526225000961 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
526225000962 ABC-2 type transporter; Region: ABC2_membrane; pfam01061
526225000963 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
526225000964 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
526225000965 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
526225000966 Probable Catalytic site; other site
526225000967 metal-binding site
526225000968 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
526225000969 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526225000970 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
526225000971 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
526225000972 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
526225000973 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
526225000974 Chain length determinant protein; Region: Wzz; pfam02706
526225000975 capsular exopolysaccharide family; Region: eps_fam; TIGR01007
526225000976 Phosphotransferase enzyme family; Region: APH; pfam01636
526225000977 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
526225000978 active site
526225000979 ATP binding site [chemical binding]; other site
526225000980 substrate binding site [chemical binding]; other site
526225000981 HprK-related kinase B; Region: HprK_rel_B; TIGR04355
526225000982 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
526225000983 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
526225000984 active site
526225000985 Putative zinc binding domain; Region: Methyltransf_13; pfam08421
526225000986 Methyltransferase domain; Region: Methyltransf_23; pfam13489
526225000987 Methyltransferase domain; Region: Methyltransf_12; pfam08242
526225000988 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
526225000989 nitrate reductase catalytic subunit; Provisional; Region: PRK13532
526225000990 Putative zinc binding domain; Region: Methyltransf_13; pfam08421
526225000991 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
526225000992 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
526225000993 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
526225000994 extended (e) SDRs; Region: SDR_e; cd08946
526225000995 NAD(P) binding site [chemical binding]; other site
526225000996 active site
526225000997 substrate binding site [chemical binding]; other site
526225000998 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
526225000999 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
526225001000 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526225001001 active site
526225001002 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
526225001003 putative ADP-binding pocket [chemical binding]; other site
526225001004 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526225001005 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_11; cd13126
526225001006 Predicted glycosyltransferases [General function prediction only]; Region: COG1216
526225001007 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526225001008 active site
526225001009 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
526225001010 Bacterial sugar transferase; Region: Bac_transf; pfam02397
526225001011 Transposase, Mutator family; Region: Transposase_mut; pfam00872
526225001012 MULE transposase domain; Region: MULE; pfam10551
526225001013 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
526225001014 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225001015 NAD(P) binding site [chemical binding]; other site
526225001016 active site
526225001017 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
526225001018 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
526225001019 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
526225001020 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
526225001021 Predicted membrane protein [Function unknown]; Region: COG4763
526225001022 Acyltransferase family; Region: Acyl_transf_3; pfam01757
526225001023 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
526225001024 active site
526225001025 catalytic residues [active]
526225001026 Chain length determinant protein; Region: Wzz; cl15801
526225001027 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
526225001028 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
526225001029 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526225001030 active site
526225001031 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
526225001032 ABC-2 type transporter; Region: ABC2_membrane; cl17235
526225001033 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
526225001034 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
526225001035 Walker A/P-loop; other site
526225001036 ATP binding site [chemical binding]; other site
526225001037 Q-loop/lid; other site
526225001038 ABC transporter signature motif; other site
526225001039 Walker B; other site
526225001040 D-loop; other site
526225001041 H-loop/switch region; other site
526225001042 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
526225001043 putative carbohydrate binding site [chemical binding]; other site
526225001044 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
526225001045 active site
526225001046 Protein of unknown function (DUF563); Region: DUF563; pfam04577
526225001047 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
526225001048 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526225001049 active site
526225001050 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
526225001051 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
526225001052 active site
526225001053 active site
526225001054 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
526225001055 hypothetical protein; Provisional; Region: PRK07208
526225001056 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526225001057 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526225001058 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
526225001059 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
526225001060 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
526225001061 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
526225001062 putative ADP-binding pocket [chemical binding]; other site
526225001063 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526225001064 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
526225001065 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526225001066 active site
526225001067 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
526225001068 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
526225001069 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
526225001070 active site
526225001071 Ribonuclease P; Region: Ribonuclease_P; cl00457
526225001072 Methyltransferase domain; Region: Methyltransf_23; pfam13489
526225001073 Methyltransferase domain; Region: Methyltransf_11; pfam08241
526225001074 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526225001075 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526225001076 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
526225001077 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
526225001078 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
526225001079 putative active site [active]
526225001080 Predicted glycosyltransferases [General function prediction only]; Region: COG1216
526225001081 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
526225001082 active site
526225001083 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
526225001084 putative ADP-binding pocket [chemical binding]; other site
526225001085 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526225001086 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526225001087 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
526225001088 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526225001089 active site
526225001090 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
526225001091 Bacterial sugar transferase; Region: Bac_transf; pfam02397
526225001092 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
526225001093 Bacterial sugar transferase; Region: Bac_transf; pfam02397
526225001094 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
526225001095 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
526225001096 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
526225001097 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
526225001098 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
526225001099 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
526225001100 Transposase; Region: DEDD_Tnp_IS110; pfam01548
526225001101 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
526225001102 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
526225001103 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
526225001104 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
526225001105 Probable Catalytic site; other site
526225001106 metal-binding site
526225001107 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
526225001108 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
526225001109 Ligand binding site; other site
526225001110 Putative Catalytic site; other site
526225001111 DXD motif; other site
526225001112 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
526225001113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225001114 NAD(P) binding site [chemical binding]; other site
526225001115 active site
526225001116 Predicted acyltransferases [Lipid metabolism]; Region: COG1835
526225001117 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526225001118 AMP-binding enzyme; Region: AMP-binding; pfam00501
526225001119 acyl-activating enzyme (AAE) consensus motif; other site
526225001120 AMP binding site [chemical binding]; other site
526225001121 Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526225001122 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
526225001123 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
526225001124 active site
526225001125 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
526225001126 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
526225001127 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
526225001128 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526225001129 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
526225001130 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
526225001131 putative active site [active]
526225001132 Predicted glycosyltransferases [General function prediction only]; Region: COG1216
526225001133 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
526225001134 active site
526225001135 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526225001136 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
526225001137 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526225001138 acyl-activating enzyme (AAE) consensus motif; other site
526225001139 AMP binding site [chemical binding]; other site
526225001140 active site
526225001141 CoA binding site [chemical binding]; other site
526225001142 Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526225001143 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
526225001144 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
526225001145 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413
526225001146 active site
526225001147 catalytic residues [active]
526225001148 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
526225001149 Ligand binding site; other site
526225001150 Putative Catalytic site; other site
526225001151 DXD motif; other site
526225001152 hypothetical protein; Provisional; Region: PRK07945
526225001153 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
526225001154 active site
526225001155 Predicted membrane protein [Function unknown]; Region: COG2259
526225001156 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
526225001157 active site
526225001158 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
526225001159 CGNR zinc finger; Region: zf-CGNR; pfam11706
526225001160 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
526225001161 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
526225001162 phosphate binding site [ion binding]; other site
526225001163 Transcriptional regulators [Transcription]; Region: MarR; COG1846
526225001164 MarR family; Region: MarR_2; pfam12802
526225001165 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526225001166 active site
526225001167 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526225001168 active site
526225001169 motif I; other site
526225001170 motif II; other site
526225001171 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
526225001172 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
526225001173 putative active site [active]
526225001174 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
526225001175 putative ADP-binding pocket [chemical binding]; other site
526225001176 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
526225001177 dimer interface [polypeptide binding]; other site
526225001178 active site
526225001179 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
526225001180 ATP binding site [chemical binding]; other site
526225001181 substrate binding site [chemical binding]; other site
526225001182 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
526225001183 active site
526225001184 nucleotide binding site [chemical binding]; other site
526225001185 HIGH motif; other site
526225001186 KMSKS motif; other site
526225001187 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
526225001188 putative active site [active]
526225001189 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
526225001190 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
526225001191 metal ion-dependent adhesion site (MIDAS); other site
526225001192 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
526225001193 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
526225001194 NAD binding site [chemical binding]; other site
526225001195 putative substrate binding site 2 [chemical binding]; other site
526225001196 putative substrate binding site 1 [chemical binding]; other site
526225001197 active site
526225001198 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944
526225001199 prephenate dehydrogenase; Validated; Region: PRK08507
526225001200 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
526225001201 CoenzymeA binding site [chemical binding]; other site
526225001202 subunit interaction site [polypeptide binding]; other site
526225001203 PHB binding site; other site
526225001204 Methyltransferase domain; Region: Methyltransf_31; pfam13847
526225001205 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225001206 S-adenosylmethionine binding site [chemical binding]; other site
526225001207 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
526225001208 epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247
526225001209 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526225001210 motif II; other site
526225001211 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
526225001212 nucleoside/Zn binding site; other site
526225001213 dimer interface [polypeptide binding]; other site
526225001214 catalytic motif [active]
526225001215 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526225001216 Catalytic domain of Protein Kinases; Region: PKc; cd00180
526225001217 active site
526225001218 ATP binding site [chemical binding]; other site
526225001219 substrate binding site [chemical binding]; other site
526225001220 activation loop (A-loop); other site
526225001221 EamA-like transporter family; Region: EamA; pfam00892
526225001222 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
526225001223 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526225001224 Walker A motif; other site
526225001225 ATP binding site [chemical binding]; other site
526225001226 Walker B motif; other site
526225001227 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
526225001228 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826
526225001229 putative hydrophobic ligand binding site [chemical binding]; other site
526225001230 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526225001231 dimerization interface [polypeptide binding]; other site
526225001232 putative DNA binding site [nucleotide binding]; other site
526225001233 putative Zn2+ binding site [ion binding]; other site
526225001234 hypothetical protein; Validated; Region: PRK00153
526225001235 recombination protein RecR; Reviewed; Region: recR; PRK00076
526225001236 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
526225001237 RecR protein; Region: RecR; pfam02132
526225001238 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
526225001239 putative active site [active]
526225001240 putative metal-binding site [ion binding]; other site
526225001241 tetramer interface [polypeptide binding]; other site
526225001242 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
526225001243 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
526225001244 peptide binding site [polypeptide binding]; other site
526225001245 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
526225001246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526225001247 dimer interface [polypeptide binding]; other site
526225001248 conserved gate region; other site
526225001249 putative PBP binding loops; other site
526225001250 ABC-ATPase subunit interface; other site
526225001251 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
526225001252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526225001253 dimer interface [polypeptide binding]; other site
526225001254 conserved gate region; other site
526225001255 putative PBP binding loops; other site
526225001256 ABC-ATPase subunit interface; other site
526225001257 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
526225001258 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
526225001259 Walker A/P-loop; other site
526225001260 ATP binding site [chemical binding]; other site
526225001261 Q-loop/lid; other site
526225001262 ABC transporter signature motif; other site
526225001263 Walker B; other site
526225001264 D-loop; other site
526225001265 H-loop/switch region; other site
526225001266 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
526225001267 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
526225001268 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
526225001269 Walker A/P-loop; other site
526225001270 ATP binding site [chemical binding]; other site
526225001271 Q-loop/lid; other site
526225001272 ABC transporter signature motif; other site
526225001273 Walker B; other site
526225001274 D-loop; other site
526225001275 H-loop/switch region; other site
526225001276 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
526225001277 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
526225001278 iron-sulfur cluster [ion binding]; other site
526225001279 [2Fe-2S] cluster binding site [ion binding]; other site
526225001280 Repair protein; Region: Repair_PSII; pfam04536
526225001281 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
526225001282 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526225001283 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
526225001284 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526225001285 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
526225001286 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199
526225001287 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
526225001288 metal binding site [ion binding]; metal-binding site
526225001289 active site
526225001290 I-site; other site
526225001291 Pirin; Region: Pirin; pfam02678
526225001292 Pirin-related protein [General function prediction only]; Region: COG1741
526225001293 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
526225001294 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
526225001295 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
526225001296 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
526225001297 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
526225001298 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
526225001299 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526225001300 ABC transporter; Region: ABC_tran_2; pfam12848
526225001301 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526225001302 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644
526225001303 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
526225001304 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
526225001305 Domain of unknown function (DUF4040); Region: DUF4040; cl00676
526225001306 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946
526225001307 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665
526225001308 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
526225001309 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899
526225001310 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
526225001311 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
526225001312 putative dimer interface [polypeptide binding]; other site
526225001313 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
526225001314 2-isopropylmalate synthase; Validated; Region: PRK03739
526225001315 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
526225001316 active site
526225001317 catalytic residues [active]
526225001318 metal binding site [ion binding]; metal-binding site
526225001319 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
526225001320 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526225001321 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526225001322 non-specific DNA binding site [nucleotide binding]; other site
526225001323 salt bridge; other site
526225001324 sequence-specific DNA binding site [nucleotide binding]; other site
526225001325 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
526225001326 Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_1; cd09104
526225001327 putative active site [active]
526225001328 catalytic site [active]
526225001329 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105
526225001330 putative active site [active]
526225001331 catalytic site [active]
526225001332 aspartate kinase; Reviewed; Region: PRK06635
526225001333 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
526225001334 putative nucleotide binding site [chemical binding]; other site
526225001335 putative catalytic residues [active]
526225001336 putative Mg ion binding site [ion binding]; other site
526225001337 putative aspartate binding site [chemical binding]; other site
526225001338 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
526225001339 putative allosteric regulatory site; other site
526225001340 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
526225001341 putative allosteric regulatory residue; other site
526225001342 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
526225001343 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
526225001344 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
526225001345 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
526225001346 Domain of unknown function DUF21; Region: DUF21; pfam01595
526225001347 FOG: CBS domain [General function prediction only]; Region: COG0517
526225001348 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
526225001349 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
526225001350 Domain of unknown function DUF21; Region: DUF21; pfam01595
526225001351 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
526225001352 Transporter associated domain; Region: CorC_HlyC; smart01091
526225001353 phosphodiesterase YaeI; Provisional; Region: PRK11340
526225001354 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
526225001355 putative active site [active]
526225001356 putative metal binding site [ion binding]; other site
526225001357 Yqey-like protein; Region: YqeY; cl17540
526225001358 Transglycosylase; Region: Transgly; pfam00912
526225001359 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
526225001360 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
526225001361 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
526225001362 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
526225001363 P loop; other site
526225001364 Nucleotide binding site [chemical binding]; other site
526225001365 DTAP/Switch II; other site
526225001366 Switch I; other site
526225001367 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
526225001368 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
526225001369 DTAP/Switch II; other site
526225001370 Switch I; other site
526225001371 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
526225001372 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
526225001373 homotrimer interaction site [polypeptide binding]; other site
526225001374 putative active site [active]
526225001375 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
526225001376 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
526225001377 ligand binding site [chemical binding]; other site
526225001378 flexible hinge region; other site
526225001379 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
526225001380 non-specific DNA interactions [nucleotide binding]; other site
526225001381 DNA binding site [nucleotide binding]
526225001382 sequence specific DNA binding site [nucleotide binding]; other site
526225001383 putative cAMP binding site [chemical binding]; other site
526225001384 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
526225001385 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
526225001386 minor groove reading motif; other site
526225001387 helix-hairpin-helix signature motif; other site
526225001388 substrate binding pocket [chemical binding]; other site
526225001389 active site
526225001390 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
526225001391 Thioredoxin-like; Region: Thioredoxin_8; pfam13905
526225001392 catalytic residues [active]
526225001393 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
526225001394 putative active site [active]
526225001395 putative CoA binding site [chemical binding]; other site
526225001396 nudix motif; other site
526225001397 metal binding site [ion binding]; metal-binding site
526225001398 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
526225001399 Colicin V production protein; Region: Colicin_V; pfam02674
526225001400 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
526225001401 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
526225001402 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526225001403 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
526225001404 acetyl-CoA synthetase; Provisional; Region: PRK00174
526225001405 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
526225001406 active site
526225001407 CoA binding site [chemical binding]; other site
526225001408 acyl-activating enzyme (AAE) consensus motif; other site
526225001409 AMP binding site [chemical binding]; other site
526225001410 acetate binding site [chemical binding]; other site
526225001411 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
526225001412 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
526225001413 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
526225001414 HflX GTPase family; Region: HflX; cd01878
526225001415 G1 box; other site
526225001416 GTP/Mg2+ binding site [chemical binding]; other site
526225001417 Switch I region; other site
526225001418 G2 box; other site
526225001419 G3 box; other site
526225001420 Switch II region; other site
526225001421 G4 box; other site
526225001422 G5 box; other site
526225001423 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
526225001424 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
526225001425 short chain dehydrogenase; Provisional; Region: PRK08263
526225001426 classical (c) SDRs; Region: SDR_c; cd05233
526225001427 NAD(P) binding site [chemical binding]; other site
526225001428 active site
526225001429 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
526225001430 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
526225001431 DNA binding residues [nucleotide binding]
526225001432 dimer interface [polypeptide binding]; other site
526225001433 [2Fe-2S] cluster binding site [ion binding]; other site
526225001434 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
526225001435 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
526225001436 putative active site [active]
526225001437 metal binding site [ion binding]; metal-binding site
526225001438 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526225001439 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526225001440 non-specific DNA binding site [nucleotide binding]; other site
526225001441 salt bridge; other site
526225001442 sequence-specific DNA binding site [nucleotide binding]; other site
526225001443 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
526225001444 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
526225001445 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
526225001446 homodimer interface [polypeptide binding]; other site
526225001447 active site
526225001448 SAM binding site [chemical binding]; other site
526225001449 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
526225001450 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
526225001451 putative dimer interface [polypeptide binding]; other site
526225001452 active site pocket [active]
526225001453 hypothetical protein; Provisional; Region: PRK07908
526225001454 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
526225001455 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225001456 homodimer interface [polypeptide binding]; other site
526225001457 catalytic residue [active]
526225001458 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
526225001459 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
526225001460 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
526225001461 Walker A/P-loop; other site
526225001462 ATP binding site [chemical binding]; other site
526225001463 Q-loop/lid; other site
526225001464 ABC transporter signature motif; other site
526225001465 Walker B; other site
526225001466 D-loop; other site
526225001467 H-loop/switch region; other site
526225001468 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
526225001469 cobalt transport protein CbiN; Provisional; Region: PRK02898
526225001470 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397
526225001471 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
526225001472 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
526225001473 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
526225001474 catalytic triad [active]
526225001475 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
526225001476 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
526225001477 homodimer interface [polypeptide binding]; other site
526225001478 Walker A motif; other site
526225001479 ATP binding site [chemical binding]; other site
526225001480 hydroxycobalamin binding site [chemical binding]; other site
526225001481 Walker B motif; other site
526225001482 magnesium chelatase subunit I; Provisional; Region: bchI; PRK13407
526225001483 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
526225001484 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
526225001485 metal ion-dependent adhesion site (MIDAS); other site
526225001486 Transcriptional regulators [Transcription]; Region: MarR; COG1846
526225001487 Winged helix DNA-binding domain; Region: HTH_34; pfam13601
526225001488 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
526225001489 Putative ammonia monooxygenase; Region: AmoA; pfam05145
526225001490 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
526225001491 Methyltransferase domain; Region: Methyltransf_23; pfam13489
526225001492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225001493 S-adenosylmethionine binding site [chemical binding]; other site
526225001494 PemK-like protein; Region: PemK; pfam02452
526225001495 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
526225001496 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
526225001497 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
526225001498 active site
526225001499 cobyric acid synthase; Provisional; Region: PRK00784
526225001500 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
526225001501 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
526225001502 catalytic triad [active]
526225001503 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
526225001504 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
526225001505 putative acyl-acceptor binding pocket; other site
526225001506 PAS fold; Region: PAS_3; pfam08447
526225001507 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
526225001508 putative active site [active]
526225001509 heme pocket [chemical binding]; other site
526225001510 ANTAR domain; Region: ANTAR; pfam03861
526225001511 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
526225001512 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
526225001513 active site
526225001514 catalytic residues [active]
526225001515 metal binding site [ion binding]; metal-binding site
526225001516 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
526225001517 active site
526225001518 putative homodimer interface [polypeptide binding]; other site
526225001519 SAM binding site [chemical binding]; other site
526225001520 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
526225001521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
526225001522 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
526225001523 SAM binding site [chemical binding]; other site
526225001524 active site
526225001525 homodimer interface [polypeptide binding]; other site
526225001526 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
526225001527 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
526225001528 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
526225001529 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
526225001530 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526225001531 motif II; other site
526225001532 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
526225001533 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
526225001534 conserved cys residue [active]
526225001535 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526225001536 MarR family; Region: MarR_2; pfam12802
526225001537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225001538 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966
526225001539 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
526225001540 phosphate binding site [ion binding]; other site
526225001541 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
526225001542 active site
526225001543 SAM binding site [chemical binding]; other site
526225001544 homodimer interface [polypeptide binding]; other site
526225001545 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
526225001546 active site
526225001547 SAM binding site [chemical binding]; other site
526225001548 homodimer interface [polypeptide binding]; other site
526225001549 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
526225001550 Precorrin-8X methylmutase; Region: CbiC; pfam02570
526225001551 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
526225001552 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526225001553 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526225001554 sequence-specific DNA binding site [nucleotide binding]; other site
526225001555 salt bridge; other site
526225001556 TIGR04222 domain; Region: near_uncomplex
526225001557 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
526225001558 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
526225001559 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
526225001560 Cobalamin-5-phosphate synthase; Region: CobS; cl00415
526225001561 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
526225001562 homotrimer interface [polypeptide binding]; other site
526225001563 Walker A motif; other site
526225001564 GTP binding site [chemical binding]; other site
526225001565 Walker B motif; other site
526225001566 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526225001567 catalytic core [active]
526225001568 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526225001569 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526225001570 active site
526225001571 catalytic tetrad [active]
526225001572 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
526225001573 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526225001574 motif II; other site
526225001575 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
526225001576 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
526225001577 Type II/IV secretion system protein; Region: T2SE; pfam00437
526225001578 Walker A motif; other site
526225001579 ATP binding site [chemical binding]; other site
526225001580 Walker B motif; other site
526225001581 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
526225001582 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
526225001583 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
526225001584 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
526225001585 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526225001586 ATP binding site [chemical binding]; other site
526225001587 putative Mg++ binding site [ion binding]; other site
526225001588 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526225001589 ATP-binding site [chemical binding]; other site
526225001590 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
526225001591 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
526225001592 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
526225001593 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
526225001594 DNA topoisomerase I subunit omega; Validated; Region: PRK07561
526225001595 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
526225001596 active site
526225001597 interdomain interaction site; other site
526225001598 putative metal-binding site [ion binding]; other site
526225001599 nucleotide binding site [chemical binding]; other site
526225001600 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
526225001601 domain I; other site
526225001602 phosphate binding site [ion binding]; other site
526225001603 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
526225001604 domain II; other site
526225001605 domain III; other site
526225001606 nucleotide binding site [chemical binding]; other site
526225001607 DNA binding groove [nucleotide binding]
526225001608 catalytic site [active]
526225001609 domain IV; other site
526225001610 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
526225001611 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
526225001612 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
526225001613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225001614 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
526225001615 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
526225001616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225001617 S-adenosylmethionine binding site [chemical binding]; other site
526225001618 thymidylate kinase; Validated; Region: tmk; PRK00698
526225001619 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
526225001620 TMP-binding site; other site
526225001621 ATP-binding site [chemical binding]; other site
526225001622 DNA polymerase III subunit delta'; Validated; Region: PRK07940
526225001623 DNA polymerase III subunit delta'; Validated; Region: PRK08485
526225001624 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
526225001625 dimer interface [polypeptide binding]; other site
526225001626 substrate binding site [chemical binding]; other site
526225001627 metal binding sites [ion binding]; metal-binding site
526225001628 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
526225001629 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
526225001630 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
526225001631 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
526225001632 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
526225001633 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
526225001634 Ligand Binding Site [chemical binding]; other site
526225001635 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
526225001636 active site
526225001637 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
526225001638 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526225001639 Walker A motif; other site
526225001640 ATP binding site [chemical binding]; other site
526225001641 Walker B motif; other site
526225001642 arginine finger; other site
526225001643 Peptidase family M41; Region: Peptidase_M41; pfam01434
526225001644 GTP cyclohydrolase I; Provisional; Region: PLN03044
526225001645 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642
526225001646 homodecamer interface [polypeptide binding]; other site
526225001647 active site
526225001648 putative catalytic site residues [active]
526225001649 zinc binding site [ion binding]; other site
526225001650 GTP-CH-I/GFRP interaction surface; other site
526225001651 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
526225001652 substrate binding pocket [chemical binding]; other site
526225001653 inhibitor binding site; inhibition site
526225001654 Dihydroneopterin aldolase; Region: FolB; pfam02152
526225001655 active site
526225001656 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
526225001657 catalytic center binding site [active]
526225001658 ATP binding site [chemical binding]; other site
526225001659 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
526225001660 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
526225001661 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
526225001662 Walker A/P-loop; other site
526225001663 ATP binding site [chemical binding]; other site
526225001664 Q-loop/lid; other site
526225001665 ABC transporter signature motif; other site
526225001666 Walker B; other site
526225001667 D-loop; other site
526225001668 H-loop/switch region; other site
526225001669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526225001670 dimer interface [polypeptide binding]; other site
526225001671 conserved gate region; other site
526225001672 ABC-ATPase subunit interface; other site
526225001673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526225001674 ABC-ATPase subunit interface; other site
526225001675 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
526225001676 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
526225001677 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
526225001678 Rossmann-like domain; Region: Rossmann-like; pfam10727
526225001679 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
526225001680 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380
526225001681 active site
526225001682 nucleotide binding site [chemical binding]; other site
526225001683 HIGH motif; other site
526225001684 KMSKS motif; other site
526225001685 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
526225001686 tetramerization interface [polypeptide binding]; other site
526225001687 active site
526225001688 L-aspartate oxidase; Provisional; Region: PRK07804
526225001689 L-aspartate oxidase; Provisional; Region: PRK06175
526225001690 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
526225001691 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
526225001692 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
526225001693 dimerization interface [polypeptide binding]; other site
526225001694 active site
526225001695 Type III pantothenate kinase; Region: Pan_kinase; cl17198
526225001696 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
526225001697 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
526225001698 dimer interface [polypeptide binding]; other site
526225001699 putative anticodon binding site; other site
526225001700 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
526225001701 motif 1; other site
526225001702 dimer interface [polypeptide binding]; other site
526225001703 active site
526225001704 motif 2; other site
526225001705 motif 3; other site
526225001706 Lsr2; Region: Lsr2; pfam11774
526225001707 Clp protease ATP binding subunit; Region: clpC; CHL00095
526225001708 Clp amino terminal domain; Region: Clp_N; pfam02861
526225001709 Clp amino terminal domain; Region: Clp_N; pfam02861
526225001710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526225001711 Walker A motif; other site
526225001712 ATP binding site [chemical binding]; other site
526225001713 Walker B motif; other site
526225001714 arginine finger; other site
526225001715 UvrB/uvrC motif; Region: UVR; pfam02151
526225001716 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526225001717 Walker A motif; other site
526225001718 ATP binding site [chemical binding]; other site
526225001719 Walker B motif; other site
526225001720 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
526225001721 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
526225001722 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
526225001723 minor groove reading motif; other site
526225001724 helix-hairpin-helix signature motif; other site
526225001725 active site
526225001726 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
526225001727 DNA integrity scanning protein DisA; Provisional; Region: PRK13482
526225001728 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
526225001729 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
526225001730 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
526225001731 DNA repair protein RadA; Provisional; Region: PRK11823
526225001732 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
526225001733 Walker A motif; other site
526225001734 ATP binding site [chemical binding]; other site
526225001735 Walker B motif; other site
526225001736 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
526225001737 Protein of unknown function (DUF461); Region: DUF461; cl01071
526225001738 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
526225001739 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
526225001740 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
526225001741 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526225001742 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526225001743 DNA binding residues [nucleotide binding]
526225001744 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
526225001745 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526225001746 active site
526225001747 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
526225001748 homotrimer interaction site [polypeptide binding]; other site
526225001749 zinc binding site [ion binding]; other site
526225001750 CDP-binding sites; other site
526225001751 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
526225001752 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
526225001753 active site
526225001754 HIGH motif; other site
526225001755 nucleotide binding site [chemical binding]; other site
526225001756 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
526225001757 KMSKS motif; other site
526225001758 tRNA binding surface [nucleotide binding]; other site
526225001759 anticodon binding site; other site
526225001760 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840
526225001761 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
526225001762 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
526225001763 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
526225001764 Protein of unknown function (DUF445); Region: DUF445; pfam04286
526225001765 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
526225001766 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
526225001767 protein binding site [polypeptide binding]; other site
526225001768 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424
526225001769 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
526225001770 Ligand Binding Site [chemical binding]; other site
526225001771 Lysine efflux permease [General function prediction only]; Region: COG1279
526225001772 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
526225001773 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526225001774 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
526225001775 dimerization interface [polypeptide binding]; other site
526225001776 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526225001777 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526225001778 non-specific DNA binding site [nucleotide binding]; other site
526225001779 salt bridge; other site
526225001780 sequence-specific DNA binding site [nucleotide binding]; other site
526225001781 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
526225001782 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
526225001783 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
526225001784 Walker A motif; other site
526225001785 ATP binding site [chemical binding]; other site
526225001786 Walker B motif; other site
526225001787 TadE-like protein; Region: TadE; pfam07811
526225001788 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
526225001789 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
526225001790 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
526225001791 Abi-like protein; Region: Abi_2; pfam07751
526225001792 AAA-like domain; Region: AAA_10; pfam12846
526225001793 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
526225001794 Peptidase family M23; Region: Peptidase_M23; pfam01551
526225001795 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
526225001796 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
526225001797 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
526225001798 Helix-turn-helix domain; Region: HTH_38; pfam13936
526225001799 Homeodomain-like domain; Region: HTH_32; pfam13565
526225001800 Integrase core domain; Region: rve; pfam00665
526225001801 DDE superfamily endonuclease; Region: DDE_4; pfam13359
526225001802 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
526225001803 Transglycosylase; Region: Transgly; pfam00912
526225001804 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
526225001805 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
526225001806 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
526225001807 putative active site [active]
526225001808 putative metal binding site [ion binding]; other site
526225001809 Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765
526225001810 Tetratricopeptide repeat; Region: TPR_10; cl17452
526225001811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225001812 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225001813 active site
526225001814 phosphorylation site [posttranslational modification]
526225001815 intermolecular recognition site; other site
526225001816 dimerization interface [polypeptide binding]; other site
526225001817 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225001818 DNA binding residues [nucleotide binding]
526225001819 dimerization interface [polypeptide binding]; other site
526225001820 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
526225001821 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
526225001822 Lsr2; Region: Lsr2; pfam11774
526225001823 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
526225001824 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
526225001825 Lsr2; Region: Lsr2; pfam11774
526225001826 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
526225001827 active site
526225001828 Predicted transcriptional regulator [Transcription]; Region: COG4742
526225001829 Fic/DOC family; Region: Fic; cl00960
526225001830 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
526225001831 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225001832 NAD(P) binding site [chemical binding]; other site
526225001833 active site
526225001834 TIR domain; Region: TIR_2; pfam13676
526225001835 TIR domain; Region: TIR_2; pfam13676
526225001836 TIR domain; Region: TIR_2; pfam13676
526225001837 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
526225001838 TrwC relaxase; Region: TrwC; pfam08751
526225001839 AAA domain; Region: AAA_30; pfam13604
526225001840 Family description; Region: UvrD_C_2; pfam13538
526225001841 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
526225001842 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
526225001843 active site
526225001844 metal binding site [ion binding]; metal-binding site
526225001845 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
526225001846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225001847 ATP binding site [chemical binding]; other site
526225001848 Mg2+ binding site [ion binding]; other site
526225001849 G-X-G motif; other site
526225001850 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526225001851 DNA binding residues [nucleotide binding]
526225001852 AIPR protein; Region: AIPR; pfam10592
526225001853 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390
526225001854 Z1 domain; Region: Z1; pfam10593
526225001855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225001856 ATP binding site [chemical binding]; other site
526225001857 Mg2+ binding site [ion binding]; other site
526225001858 G-X-G motif; other site
526225001859 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
526225001860 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
526225001861 cofactor binding site; other site
526225001862 DNA binding site [nucleotide binding]
526225001863 substrate interaction site [chemical binding]; other site
526225001864 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
526225001865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225001866 ATP binding site [chemical binding]; other site
526225001867 Mg2+ binding site [ion binding]; other site
526225001868 G-X-G motif; other site
526225001869 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
526225001870 additional DNA contacts [nucleotide binding]; other site
526225001871 mismatch recognition site; other site
526225001872 active site
526225001873 zinc binding site [ion binding]; other site
526225001874 DNA intercalation site [nucleotide binding]; other site
526225001875 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
526225001876 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
526225001877 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
526225001878 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
526225001879 active site
526225001880 DNA binding site [nucleotide binding]
526225001881 Int/Topo IB signature motif; other site
526225001882 HAMP domain; Region: HAMP; pfam00672
526225001883 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
526225001884 dimerization interface [polypeptide binding]; other site
526225001885 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
526225001886 dimer interface [polypeptide binding]; other site
526225001887 phosphorylation site [posttranslational modification]
526225001888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225001889 ATP binding site [chemical binding]; other site
526225001890 Mg2+ binding site [ion binding]; other site
526225001891 G-X-G motif; other site
526225001892 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526225001893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225001894 active site
526225001895 phosphorylation site [posttranslational modification]
526225001896 intermolecular recognition site; other site
526225001897 dimerization interface [polypeptide binding]; other site
526225001898 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526225001899 DNA binding site [nucleotide binding]
526225001900 Dodecin; Region: Dodecin; pfam07311
526225001901 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
526225001902 FOG: CBS domain [General function prediction only]; Region: COG0517
526225001903 Predicted permeases [General function prediction only]; Region: RarD; COG2962
526225001904 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
526225001905 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
526225001906 Putative lysophospholipase; Region: Hydrolase_4; pfam12146
526225001907 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
526225001908 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
526225001909 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
526225001910 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
526225001911 Walker A/P-loop; other site
526225001912 ATP binding site [chemical binding]; other site
526225001913 Q-loop/lid; other site
526225001914 ABC transporter signature motif; other site
526225001915 Walker B; other site
526225001916 D-loop; other site
526225001917 H-loop/switch region; other site
526225001918 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
526225001919 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
526225001920 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526225001921 active site
526225001922 motif I; other site
526225001923 motif II; other site
526225001924 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
526225001925 threonine synthase; Validated; Region: PRK07591
526225001926 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
526225001927 homodimer interface [polypeptide binding]; other site
526225001928 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225001929 catalytic residue [active]
526225001930 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
526225001931 DNA-binding site [nucleotide binding]; DNA binding site
526225001932 RNA-binding motif; other site
526225001933 classical (c) SDRs; Region: SDR_c; cd05233
526225001934 NAD(P) binding site [chemical binding]; other site
526225001935 active site
526225001936 chaperonin GroEL; Reviewed; Region: groEL; PRK12849
526225001937 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
526225001938 ring oligomerisation interface [polypeptide binding]; other site
526225001939 ATP/Mg binding site [chemical binding]; other site
526225001940 stacking interactions; other site
526225001941 hinge regions; other site
526225001942 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854
526225001943 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
526225001944 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
526225001945 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
526225001946 Interdomain contacts; other site
526225001947 Protein of unknown function DUF72; Region: DUF72; pfam01904
526225001948 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526225001949 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526225001950 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
526225001951 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223
526225001952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
526225001953 acetylornithine deacetylase; Validated; Region: PRK06915
526225001954 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
526225001955 metal binding site [ion binding]; metal-binding site
526225001956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225001957 metabolite-proton symporter; Region: 2A0106; TIGR00883
526225001958 putative substrate translocation pore; other site
526225001959 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225001960 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225001961 DNA binding residues [nucleotide binding]
526225001962 dimerization interface [polypeptide binding]; other site
526225001963 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
526225001964 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
526225001965 ATP binding site [chemical binding]; other site
526225001966 putative Mg++ binding site [ion binding]; other site
526225001967 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
526225001968 putative active site [active]
526225001969 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
526225001970 Predicted ATPase [General function prediction only]; Region: COG3903
526225001971 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225001972 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225001973 DNA binding residues [nucleotide binding]
526225001974 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
526225001975 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
526225001976 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526225001977 ATP binding site [chemical binding]; other site
526225001978 putative Mg++ binding site [ion binding]; other site
526225001979 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526225001980 nucleotide binding region [chemical binding]; other site
526225001981 ATP-binding site [chemical binding]; other site
526225001982 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
526225001983 WYL domain; Region: WYL; pfam13280
526225001984 AMP-binding domain protein; Validated; Region: PRK08315
526225001985 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526225001986 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
526225001987 acyl-activating enzyme (AAE) consensus motif; other site
526225001988 acyl-activating enzyme (AAE) consensus motif; other site
526225001989 putative AMP binding site [chemical binding]; other site
526225001990 putative active site [active]
526225001991 putative CoA binding site [chemical binding]; other site
526225001992 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
526225001993 putative catalytic site [active]
526225001994 putative metal binding site [ion binding]; other site
526225001995 putative phosphate binding site [ion binding]; other site
526225001996 Domain of unknown function (DUF202); Region: DUF202; cl09954
526225001997 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
526225001998 DNA-binding site [nucleotide binding]; DNA binding site
526225001999 RNA-binding motif; other site
526225002000 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
526225002001 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252
526225002002 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526225002003 MarR family; Region: MarR; pfam01047
526225002004 H+ Antiporter protein; Region: 2A0121; TIGR00900
526225002005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225002006 putative substrate translocation pore; other site
526225002007 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
526225002008 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
526225002009 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819
526225002010 putative heme binding site [chemical binding]; other site
526225002011 putative substrate binding site [chemical binding]; other site
526225002012 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526225002013 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526225002014 active site
526225002015 catalytic tetrad [active]
526225002016 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
526225002017 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
526225002018 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526225002019 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
526225002020 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
526225002021 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
526225002022 phosphoserine aminotransferase; Provisional; Region: PRK03080
526225002023 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526225002024 catalytic residue [active]
526225002025 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109
526225002026 dimer interface [polypeptide binding]; other site
526225002027 Citrate synthase; Region: Citrate_synt; pfam00285
526225002028 active site
526225002029 citrylCoA binding site [chemical binding]; other site
526225002030 oxalacetate/citrate binding site [chemical binding]; other site
526225002031 coenzyme A binding site [chemical binding]; other site
526225002032 catalytic triad [active]
526225002033 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
526225002034 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
526225002035 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
526225002036 H+ Antiporter protein; Region: 2A0121; TIGR00900
526225002037 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
526225002038 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
526225002039 Fe-S cluster binding site [ion binding]; other site
526225002040 active site
526225002041 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
526225002042 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225002043 Walker A/P-loop; other site
526225002044 ATP binding site [chemical binding]; other site
526225002045 Q-loop/lid; other site
526225002046 ABC transporter signature motif; other site
526225002047 Walker B; other site
526225002048 D-loop; other site
526225002049 H-loop/switch region; other site
526225002050 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
526225002051 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
526225002052 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526225002053 binding surface
526225002054 TPR motif; other site
526225002055 TPR repeat; Region: TPR_11; pfam13414
526225002056 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
526225002057 active site
526225002058 catalytic site [active]
526225002059 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
526225002060 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
526225002061 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
526225002062 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
526225002063 active site
526225002064 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
526225002065 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040
526225002066 ferredoxin-NADP+ reductase; Region: PLN02852
526225002067 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
526225002068 Uncharacterized conserved protein [Function unknown]; Region: COG1359
526225002069 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
526225002070 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
526225002071 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
526225002072 putative DNA binding site [nucleotide binding]; other site
526225002073 catalytic residue [active]
526225002074 putative H2TH interface [polypeptide binding]; other site
526225002075 putative catalytic residues [active]
526225002076 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
526225002077 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
526225002078 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
526225002079 DNA photolyase; Region: DNA_photolyase; pfam00875
526225002080 Predicted acetyltransferase [General function prediction only]; Region: COG2388
526225002081 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
526225002082 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526225002083 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
526225002084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225002085 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
526225002086 DNA binding site [nucleotide binding]
526225002087 Bacterial transcriptional activator domain; Region: BTAD; pfam03704
526225002088 NB-ARC domain; Region: NB-ARC; pfam00931
526225002089 AAA domain; Region: AAA_30; pfam13604
526225002090 Family description; Region: UvrD_C_2; pfam13538
526225002091 Helix-turn-helix domain; Region: HTH_17; pfam12728
526225002092 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
526225002093 active site
526225002094 DNA binding site [nucleotide binding]
526225002095 Int/Topo IB signature motif; other site
526225002096 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526225002097 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
526225002098 Na binding site [ion binding]; other site
526225002099 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
526225002100 nucleoside/Zn binding site; other site
526225002101 dimer interface [polypeptide binding]; other site
526225002102 catalytic motif [active]
526225002103 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
526225002104 hydrophobic ligand binding site; other site
526225002105 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
526225002106 NAD-dependent deacetylase; Provisional; Region: PRK00481
526225002107 Phosphotransferase enzyme family; Region: APH; pfam01636
526225002108 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
526225002109 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
526225002110 CoenzymeA binding site [chemical binding]; other site
526225002111 subunit interaction site [polypeptide binding]; other site
526225002112 PHB binding site; other site
526225002113 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
526225002114 active site
526225002115 metal binding site [ion binding]; metal-binding site
526225002116 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
526225002117 putative deacylase active site [active]
526225002118 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834
526225002119 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080
526225002120 SnoaL-like domain; Region: SnoaL_2; pfam12680
526225002121 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526225002122 MarR family; Region: MarR_2; pfam12802
526225002123 MarR family; Region: MarR_2; cl17246
526225002124 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039
526225002125 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
526225002126 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
526225002127 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
526225002128 CoA-transferase family III; Region: CoA_transf_3; pfam02515
526225002129 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
526225002130 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
526225002131 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
526225002132 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
526225002133 active site
526225002134 tetramer interface; other site
526225002135 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
526225002136 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
526225002137 dimer interface [polypeptide binding]; other site
526225002138 putative functional site; other site
526225002139 putative MPT binding site; other site
526225002140 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
526225002141 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
526225002142 PRC-barrel domain; Region: PRC; pfam05239
526225002143 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
526225002144 Catalytic site [active]
526225002145 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
526225002146 metal binding site [ion binding]; metal-binding site
526225002147 active site
526225002148 I-site; other site
526225002149 enoyl-CoA hydratase; Provisional; Region: PRK06688
526225002150 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526225002151 substrate binding site [chemical binding]; other site
526225002152 oxyanion hole (OAH) forming residues; other site
526225002153 trimer interface [polypeptide binding]; other site
526225002154 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
526225002155 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
526225002156 Predicted methyltransferases [General function prediction only]; Region: COG0313
526225002157 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
526225002158 putative SAM binding site [chemical binding]; other site
526225002159 putative homodimer interface [polypeptide binding]; other site
526225002160 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
526225002161 putative active site [active]
526225002162 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
526225002163 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
526225002164 oligomer interface [polypeptide binding]; other site
526225002165 metal binding site [ion binding]; metal-binding site
526225002166 metal binding site [ion binding]; metal-binding site
526225002167 putative Cl binding site [ion binding]; other site
526225002168 basic sphincter; other site
526225002169 hydrophobic gate; other site
526225002170 periplasmic entrance; other site
526225002171 amino acid transporter; Region: 2A0306; TIGR00909
526225002172 C-terminus of AA_permease; Region: AA_permease_C; pfam13906
526225002173 methionyl-tRNA synthetase; Reviewed; Region: PRK12268
526225002174 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
526225002175 active site
526225002176 HIGH motif; other site
526225002177 KMSKS motif; other site
526225002178 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
526225002179 tRNA binding surface [nucleotide binding]; other site
526225002180 anticodon binding site; other site
526225002181 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
526225002182 active site
526225002183 Domain of unknown function (DUF348); Region: DUF348; pfam03990
526225002184 Domain of unknown function (DUF348); Region: DUF348; pfam03990
526225002185 G5 domain; Region: G5; pfam07501
526225002186 Transglycosylase-like domain; Region: Transglycosylas; pfam06737
526225002187 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
526225002188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225002189 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
526225002190 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526225002191 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225002192 Fatty acid desaturase; Region: FA_desaturase; pfam00487
526225002193 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
526225002194 Di-iron ligands [ion binding]; other site
526225002195 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
526225002196 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
526225002197 Substrate binding site; other site
526225002198 Mg++ binding site; other site
526225002199 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
526225002200 active site
526225002201 substrate binding site [chemical binding]; other site
526225002202 CoA binding site [chemical binding]; other site
526225002203 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
526225002204 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
526225002205 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
526225002206 active site
526225002207 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
526225002208 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
526225002209 NAD(P) binding site [chemical binding]; other site
526225002210 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
526225002211 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
526225002212 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
526225002213 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
526225002214 5S rRNA interface [nucleotide binding]; other site
526225002215 CTC domain interface [polypeptide binding]; other site
526225002216 L16 interface [polypeptide binding]; other site
526225002217 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
526225002218 putative active site [active]
526225002219 catalytic residue [active]
526225002220 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
526225002221 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
526225002222 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526225002223 ATP binding site [chemical binding]; other site
526225002224 putative Mg++ binding site [ion binding]; other site
526225002225 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526225002226 nucleotide binding region [chemical binding]; other site
526225002227 ATP-binding site [chemical binding]; other site
526225002228 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
526225002229 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
526225002230 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526225002231 acyl-activating enzyme (AAE) consensus motif; other site
526225002232 AMP binding site [chemical binding]; other site
526225002233 active site
526225002234 CoA binding site [chemical binding]; other site
526225002235 Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526225002236 Thioesterase domain; Region: Thioesterase; pfam00975
526225002237 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
526225002238 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
526225002239 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334
526225002240 homodimer interface [polypeptide binding]; other site
526225002241 metal binding site [ion binding]; metal-binding site
526225002242 enolase; Provisional; Region: eno; PRK00077
526225002243 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
526225002244 dimer interface [polypeptide binding]; other site
526225002245 metal binding site [ion binding]; metal-binding site
526225002246 substrate binding pocket [chemical binding]; other site
526225002247 Protein of unknown function (DUF501); Region: DUF501; cl00652
526225002248 exopolyphosphatase; Region: exo_poly_only; TIGR03706
526225002249 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
526225002250 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019
526225002251 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
526225002252 Fe-S cluster binding site [ion binding]; other site
526225002253 DNA binding site [nucleotide binding]
526225002254 active site
526225002255 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
526225002256 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526225002257 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
526225002258 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
526225002259 PA/protease or protease-like domain interface [polypeptide binding]; other site
526225002260 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876
526225002261 Peptidase family M28; Region: Peptidase_M28; pfam04389
526225002262 active site
526225002263 metal binding site [ion binding]; metal-binding site
526225002264 Bax inhibitor 1 like; Region: BaxI_1; cl17691
526225002265 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
526225002266 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
526225002267 dimer interface [polypeptide binding]; other site
526225002268 active site
526225002269 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
526225002270 active site
526225002271 catalytic triad [active]
526225002272 oxyanion hole [active]
526225002273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
526225002274 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
526225002275 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
526225002276 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867
526225002277 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
526225002278 metal ion-dependent adhesion site (MIDAS); other site
526225002279 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
526225002280 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
526225002281 threonine dehydratase; Provisional; Region: PRK08198
526225002282 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
526225002283 tetramer interface [polypeptide binding]; other site
526225002284 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225002285 catalytic residue [active]
526225002286 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
526225002287 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225002288 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
526225002289 Walker A/P-loop; other site
526225002290 ATP binding site [chemical binding]; other site
526225002291 Q-loop/lid; other site
526225002292 ABC transporter signature motif; other site
526225002293 Walker B; other site
526225002294 D-loop; other site
526225002295 H-loop/switch region; other site
526225002296 ABC-2 type transporter; Region: ABC2_membrane; cl17235
526225002297 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
526225002298 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
526225002299 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
526225002300 active site
526225002301 Zn binding site [ion binding]; other site
526225002302 RNHCP domain; Region: RNHCP; pfam12647
526225002303 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
526225002304 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
526225002305 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
526225002306 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446
526225002307 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
526225002308 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
526225002309 catalytic residues [active]
526225002310 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
526225002311 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
526225002312 channel protein, hemolysin III family; Region: hlyIII; TIGR01065
526225002313 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
526225002314 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
526225002315 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
526225002316 catalytic residue [active]
526225002317 putative FPP diphosphate binding site; other site
526225002318 putative FPP binding hydrophobic cleft; other site
526225002319 dimer interface [polypeptide binding]; other site
526225002320 putative IPP diphosphate binding site; other site
526225002321 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875
526225002322 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
526225002323 putative active site [active]
526225002324 PhoH-like protein; Region: PhoH; pfam02562
526225002325 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
526225002326 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
526225002327 FHIPEP family; Region: FHIPEP; pfam00771
526225002328 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
526225002329 YacP-like NYN domain; Region: NYN_YacP; cl01491
526225002330 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
526225002331 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
526225002332 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
526225002333 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
526225002334 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500
526225002335 flagellar motor switch protein FliN; Region: fliN; TIGR02480
526225002336 Flagellar motor switch protein FliM; Region: FliM; pfam02154
526225002337 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
526225002338 flagellar motor protein MotS; Reviewed; Region: PRK06925
526225002339 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
526225002340 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
526225002341 ligand binding site [chemical binding]; other site
526225002342 flagellar motor protein MotA; Validated; Region: PRK08124
526225002343 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
526225002344 Flagellar protein (FlbD); Region: FlbD; pfam06289
526225002345 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
526225002346 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
526225002347 Flagellar basal body protein FlaE; Region: FlaE; pfam07559
526225002348 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
526225002349 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
526225002350 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
526225002351 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
526225002352 NlpC/P60 family; Region: NLPC_P60; pfam00877
526225002353 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
526225002354 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254
526225002355 N-acetyl-D-glucosamine binding site [chemical binding]; other site
526225002356 catalytic residue [active]
526225002357 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
526225002358 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
526225002359 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
526225002360 Walker A motif/ATP binding site; other site
526225002361 Walker B motif; other site
526225002362 Flagellar assembly protein FliH; Region: FliH; pfam02108
526225002363 flagellar motor switch protein G; Validated; Region: fliG; PRK05686
526225002364 FliG C-terminal domain; Region: FliG_C; pfam01706
526225002365 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
526225002366 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
526225002367 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
526225002368 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
526225002369 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
526225002370 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
526225002371 flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396
526225002372 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
526225002373 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
526225002374 Flagellar protein FliS; Region: FliS; cl00654
526225002375 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
526225002376 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
526225002377 flagellin; Provisional; Region: PRK12804
526225002378 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
526225002379 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
526225002380 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
526225002381 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
526225002382 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526225002383 Sigma-70 region 3; Region: Sigma70_r3; pfam04539
526225002384 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526225002385 DNA binding residues [nucleotide binding]
526225002386 FlgN protein; Region: FlgN; pfam05130
526225002387 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
526225002388 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
526225002389 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
526225002390 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
526225002391 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
526225002392 FliW protein; Region: FliW; pfam02623
526225002393 Global regulator protein family; Region: CsrA; pfam02599
526225002394 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
526225002395 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
526225002396 NlpC/P60 family; Region: NLPC_P60; cl17555
526225002397 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
526225002398 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308
526225002399 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
526225002400 dimer interface [polypeptide binding]; other site
526225002401 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
526225002402 active site
526225002403 citrylCoA binding site [chemical binding]; other site
526225002404 NADH binding [chemical binding]; other site
526225002405 cationic pore residues; other site
526225002406 oxalacetate/citrate binding site [chemical binding]; other site
526225002407 coenzyme A binding site [chemical binding]; other site
526225002408 catalytic triad [active]
526225002409 fumarate hydratase; Reviewed; Region: fumC; PRK00485
526225002410 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596
526225002411 active sites [active]
526225002412 tetramer interface [polypeptide binding]; other site
526225002413 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
526225002414 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
526225002415 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
526225002416 putative active site [active]
526225002417 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
526225002418 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
526225002419 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
526225002420 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
526225002421 generic binding surface II; other site
526225002422 generic binding surface I; other site
526225002423 Merozoite surface protein 1 (MSP1) C-terminus; Region: MSP1_C; pfam07462
526225002424 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
526225002425 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
526225002426 RmuC family; Region: RmuC; pfam02646
526225002427 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
526225002428 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
526225002429 DNA binding site [nucleotide binding]
526225002430 active site
526225002431 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
526225002432 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
526225002433 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526225002434 AlkA N-terminal domain; Region: AlkA_N; smart01009
526225002435 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
526225002436 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
526225002437 minor groove reading motif; other site
526225002438 helix-hairpin-helix signature motif; other site
526225002439 substrate binding pocket [chemical binding]; other site
526225002440 active site
526225002441 Ligand Binding Site [chemical binding]; other site
526225002442 Universal stress protein family; Region: Usp; pfam00582
526225002443 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526225002444 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225002445 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
526225002446 Isochorismatase family; Region: Isochorismatase; pfam00857
526225002447 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
526225002448 catalytic triad [active]
526225002449 conserved cis-peptide bond; other site
526225002450 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
526225002451 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526225002452 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
526225002453 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
526225002454 uncharacterized domain; Region: TIGR00702
526225002455 YcaO-like family; Region: YcaO; pfam02624
526225002456 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
526225002457 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526225002458 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526225002459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225002460 S-adenosylmethionine binding site [chemical binding]; other site
526225002461 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994
526225002462 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
526225002463 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
526225002464 Walker A/P-loop; other site
526225002465 ATP binding site [chemical binding]; other site
526225002466 Q-loop/lid; other site
526225002467 ABC transporter signature motif; other site
526225002468 Walker B; other site
526225002469 D-loop; other site
526225002470 H-loop/switch region; other site
526225002471 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
526225002472 ABC-2 type transporter; Region: ABC2_membrane; pfam01061
526225002473 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
526225002474 Histidine kinase; Region: HisKA_3; pfam07730
526225002475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225002476 ATP binding site [chemical binding]; other site
526225002477 Mg2+ binding site [ion binding]; other site
526225002478 G-X-G motif; other site
526225002479 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225002480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225002481 active site
526225002482 phosphorylation site [posttranslational modification]
526225002483 intermolecular recognition site; other site
526225002484 dimerization interface [polypeptide binding]; other site
526225002485 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225002486 dimerization interface [polypeptide binding]; other site
526225002487 DNA binding residues [nucleotide binding]
526225002488 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526225002489 Coenzyme A binding pocket [chemical binding]; other site
526225002490 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
526225002491 GTP-binding protein YchF; Reviewed; Region: PRK09601
526225002492 YchF GTPase; Region: YchF; cd01900
526225002493 G1 box; other site
526225002494 GTP/Mg2+ binding site [chemical binding]; other site
526225002495 Switch I region; other site
526225002496 G2 box; other site
526225002497 Switch II region; other site
526225002498 G3 box; other site
526225002499 G4 box; other site
526225002500 G5 box; other site
526225002501 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
526225002502 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
526225002503 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
526225002504 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
526225002505 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
526225002506 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
526225002507 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
526225002508 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
526225002509 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526225002510 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
526225002511 putative hydrophobic ligand binding site [chemical binding]; other site
526225002512 Patatin-like phospholipase; Region: Patatin; pfam01734
526225002513 nucleophile elbow; other site
526225002514 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
526225002515 Quinone oxidoreductase (QOR); Region: QOR1; cd08241
526225002516 NAD(P) binding site [chemical binding]; other site
526225002517 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570
526225002518 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526225002519 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526225002520 active site
526225002521 catalytic tetrad [active]
526225002522 PspC domain; Region: PspC; pfam04024
526225002523 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
526225002524 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
526225002525 4Fe-4S binding domain; Region: Fer4; pfam00037
526225002526 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
526225002527 L-aspartate oxidase; Provisional; Region: PRK06175
526225002528 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
526225002529 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
526225002530 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
526225002531 putative Iron-sulfur protein interface [polypeptide binding]; other site
526225002532 proximal heme binding site [chemical binding]; other site
526225002533 distal heme binding site [chemical binding]; other site
526225002534 putative dimer interface [polypeptide binding]; other site
526225002535 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
526225002536 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
526225002537 Moco binding site; other site
526225002538 metal coordination site [ion binding]; other site
526225002539 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
526225002540 FAD binding pocket [chemical binding]; other site
526225002541 conserved FAD binding motif [chemical binding]; other site
526225002542 phosphate binding motif [ion binding]; other site
526225002543 beta-alpha-beta structure motif; other site
526225002544 NAD binding pocket [chemical binding]; other site
526225002545 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
526225002546 Zn binding site [ion binding]; other site
526225002547 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
526225002548 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348
526225002549 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236
526225002550 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
526225002551 AAA ATPase domain; Region: AAA_16; pfam13191
526225002552 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225002553 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225002554 dimerization interface [polypeptide binding]; other site
526225002555 DNA binding residues [nucleotide binding]
526225002556 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
526225002557 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
526225002558 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
526225002559 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
526225002560 aromatic arch; other site
526225002561 DCoH dimer interaction site [polypeptide binding]; other site
526225002562 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
526225002563 DCoH tetramer interaction site [polypeptide binding]; other site
526225002564 substrate binding site [chemical binding]; other site
526225002565 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
526225002566 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
526225002567 Active Sites [active]
526225002568 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
526225002569 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
526225002570 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
526225002571 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
526225002572 ligand-binding site [chemical binding]; other site
526225002573 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
526225002574 Transcriptional regulator; Region: Rrf2; pfam02082
526225002575 Transcriptional regulator; Region: Rrf2; cl17282
526225002576 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
526225002577 active site
526225002578 8-oxo-dGMP binding site [chemical binding]; other site
526225002579 nudix motif; other site
526225002580 metal binding site [ion binding]; metal-binding site
526225002581 CsbD-like; Region: CsbD; pfam05532
526225002582 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
526225002583 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
526225002584 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
526225002585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526225002586 dimer interface [polypeptide binding]; other site
526225002587 conserved gate region; other site
526225002588 putative PBP binding loops; other site
526225002589 ABC-ATPase subunit interface; other site
526225002590 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
526225002591 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
526225002592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526225002593 dimer interface [polypeptide binding]; other site
526225002594 conserved gate region; other site
526225002595 putative PBP binding loops; other site
526225002596 ABC-ATPase subunit interface; other site
526225002597 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
526225002598 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
526225002599 Walker A/P-loop; other site
526225002600 ATP binding site [chemical binding]; other site
526225002601 Q-loop/lid; other site
526225002602 ABC transporter signature motif; other site
526225002603 Walker B; other site
526225002604 D-loop; other site
526225002605 H-loop/switch region; other site
526225002606 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
526225002607 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
526225002608 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
526225002609 Walker A/P-loop; other site
526225002610 ATP binding site [chemical binding]; other site
526225002611 Q-loop/lid; other site
526225002612 ABC transporter signature motif; other site
526225002613 Walker B; other site
526225002614 D-loop; other site
526225002615 H-loop/switch region; other site
526225002616 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
526225002617 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445
526225002618 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526225002619 Coenzyme A binding pocket [chemical binding]; other site
526225002620 Ferredoxin [Energy production and conversion]; Region: COG1146
526225002621 4Fe-4S binding domain; Region: Fer4; pfam00037
526225002622 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
526225002623 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
526225002624 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225002625 homodimer interface [polypeptide binding]; other site
526225002626 catalytic residue [active]
526225002627 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
526225002628 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
526225002629 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526225002630 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
526225002631 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
526225002632 putative trimer interface [polypeptide binding]; other site
526225002633 putative CoA binding site [chemical binding]; other site
526225002634 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
526225002635 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
526225002636 metal binding site [ion binding]; metal-binding site
526225002637 putative dimer interface [polypeptide binding]; other site
526225002638 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
526225002639 DivIVA domain; Region: DivI1A_domain; TIGR03544
526225002640 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
526225002641 hydrophobic ligand binding site; other site
526225002642 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783
526225002643 EamA-like transporter family; Region: EamA; pfam00892
526225002644 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
526225002645 Fibronectin type 3 domain; Region: FN3; smart00060
526225002646 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
526225002647 Interdomain contacts; other site
526225002648 Cytokine receptor motif; other site
526225002649 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
526225002650 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
526225002651 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
526225002652 interface (dimer of trimers) [polypeptide binding]; other site
526225002653 Substrate-binding/catalytic site; other site
526225002654 Zn-binding sites [ion binding]; other site
526225002655 Ribosomal protein S11; Region: Ribosomal_S11; cl00332
526225002656 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526225002657 DNA-binding site [nucleotide binding]; DNA binding site
526225002658 phytoene desaturase; Region: crtI_fam; TIGR02734
526225002659 PAS fold; Region: PAS_4; pfam08448
526225002660 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
526225002661 putative active site [active]
526225002662 heme pocket [chemical binding]; other site
526225002663 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
526225002664 GAF domain; Region: GAF_2; pfam13185
526225002665 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
526225002666 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
526225002667 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526225002668 FeS/SAM binding site; other site
526225002669 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
526225002670 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
526225002671 Catalytic site [active]
526225002672 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
526225002673 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
526225002674 Multicopper oxidase; Region: Cu-oxidase; pfam00394
526225002675 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
526225002676 Histidine kinase; Region: HisKA_3; pfam07730
526225002677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
526225002678 Mg2+ binding site [ion binding]; other site
526225002679 G-X-G motif; other site
526225002680 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225002681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225002682 active site
526225002683 phosphorylation site [posttranslational modification]
526225002684 intermolecular recognition site; other site
526225002685 dimerization interface [polypeptide binding]; other site
526225002686 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225002687 DNA binding residues [nucleotide binding]
526225002688 dimerization interface [polypeptide binding]; other site
526225002689 Response regulator receiver domain; Region: Response_reg; pfam00072
526225002690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225002691 active site
526225002692 phosphorylation site [posttranslational modification]
526225002693 intermolecular recognition site; other site
526225002694 dimerization interface [polypeptide binding]; other site
526225002695 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
526225002696 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
526225002697 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
526225002698 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
526225002699 ligand binding site; other site
526225002700 oligomer interface; other site
526225002701 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
526225002702 dimer interface [polypeptide binding]; other site
526225002703 N-terminal domain interface [polypeptide binding]; other site
526225002704 sulfate 1 binding site; other site
526225002705 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
526225002706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
526225002707 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
526225002708 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526225002709 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526225002710 DNA binding residues [nucleotide binding]
526225002711 Putative zinc-finger; Region: zf-HC2; pfam13490
526225002712 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
526225002713 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
526225002714 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
526225002715 protein binding site [polypeptide binding]; other site
526225002716 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
526225002717 Domain of unknown function DUF59; Region: DUF59; cl00941
526225002718 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
526225002719 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
526225002720 AzlC protein; Region: AzlC; pfam03591
526225002721 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
526225002722 MerR HTH family regulatory protein; Region: MerR_1; pfam13411
526225002723 DNA binding residues [nucleotide binding]
526225002724 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826
526225002725 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
526225002726 MgtE intracellular N domain; Region: MgtE_N; smart00924
526225002727 FOG: CBS domain [General function prediction only]; Region: COG0517
526225002728 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
526225002729 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567
526225002730 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
526225002731 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
526225002732 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526225002733 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526225002734 active site
526225002735 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
526225002736 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
526225002737 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
526225002738 putative NAD(P) binding site [chemical binding]; other site
526225002739 EthD domain; Region: EthD; cl17553
526225002740 hypothetical protein; Validated; Region: PRK07586
526225002741 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
526225002742 PYR/PP interface [polypeptide binding]; other site
526225002743 dimer interface [polypeptide binding]; other site
526225002744 TPP binding site [chemical binding]; other site
526225002745 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
526225002746 TPP-binding site [chemical binding]; other site
526225002747 dimer interface [polypeptide binding]; other site
526225002748 OsmC-like protein; Region: OsmC; pfam02566
526225002749 patatin-related protein; Region: TIGR03607
526225002750 Patatin-like phospholipase; Region: Patatin; pfam01734
526225002751 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
526225002752 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
526225002753 catalytic residues [active]
526225002754 catalytic nucleophile [active]
526225002755 Recombinase; Region: Recombinase; pfam07508
526225002756 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
526225002757 CHAT domain; Region: CHAT; pfam12770
526225002758 SIR2-like domain; Region: SIR2_2; pfam13289
526225002759 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526225002760 SIR2-like domain; Region: SIR2_2; pfam13289
526225002761 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
526225002762 structural tetrad; other site
526225002763 FOG: WD40 repeat [General function prediction only]; Region: COG2319
526225002764 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
526225002765 structural tetrad; other site
526225002766 WD40 repeats; Region: WD40; smart00320
526225002767 WD domain, G-beta repeat; Region: WD40; pfam00400
526225002768 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
526225002769 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
526225002770 active site
526225002771 metal binding site [ion binding]; metal-binding site
526225002772 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
526225002773 TIR domain; Region: TIR_2; pfam13676
526225002774 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
526225002775 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526225002776 catalytic residue [active]
526225002777 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
526225002778 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
526225002779 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
526225002780 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
526225002781 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
526225002782 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
526225002783 active site
526225002784 Lsr2; Region: Lsr2; pfam11774
526225002785 SnoaL-like domain; Region: SnoaL_2; pfam12680
526225002786 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
526225002787 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
526225002788 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
526225002789 PA/protease or protease-like domain interface [polypeptide binding]; other site
526225002790 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876
526225002791 Peptidase family M28; Region: Peptidase_M28; pfam04389
526225002792 active site
526225002793 metal binding site [ion binding]; metal-binding site
526225002794 Transposase; Region: DDE_Tnp_ISL3; pfam01610
526225002795 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
526225002796 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
526225002797 putative dimer interface [polypeptide binding]; other site
526225002798 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
526225002799 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
526225002800 active site
526225002801 Zn binding site [ion binding]; other site
526225002802 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
526225002803 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526225002804 active site
526225002805 motif I; other site
526225002806 motif II; other site
526225002807 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
526225002808 metal binding site [ion binding]; metal-binding site
526225002809 Peptidase family M28; Region: Peptidase_M28; pfam04389
526225002810 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
526225002811 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
526225002812 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
526225002813 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
526225002814 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
526225002815 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
526225002816 putative transposase OrfB; Reviewed; Region: PHA02517
526225002817 HTH-like domain; Region: HTH_21; pfam13276
526225002818 Integrase core domain; Region: rve; pfam00665
526225002819 Integrase core domain; Region: rve_3; pfam13683
526225002820 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
526225002821 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
526225002822 DDE superfamily endonuclease; Region: DDE_4; pfam13359
526225002823 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
526225002824 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
526225002825 active site
526225002826 catalytic site [active]
526225002827 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
526225002828 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
526225002829 putative transposase OrfB; Reviewed; Region: PHA02517
526225002830 HTH-like domain; Region: HTH_21; pfam13276
526225002831 Integrase core domain; Region: rve; pfam00665
526225002832 Integrase core domain; Region: rve_2; pfam13333
526225002833 Transposase; Region: HTH_Tnp_1; cl17663
526225002834 Animal prostaglandin endoperoxide synthase and related bacterial proteins; Region: prostaglandin_endoperoxide_synthase; cd09816
526225002835 substrate binding site [chemical binding]; other site
526225002836 homodimer interface [polypeptide binding]; other site
526225002837 heme binding site [chemical binding]; other site
526225002838 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
526225002839 putative heme binding pocket [chemical binding]; other site
526225002840 Bacterial transcriptional activator domain; Region: BTAD; smart01043
526225002841 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
526225002842 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526225002843 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
526225002844 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
526225002845 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
526225002846 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
526225002847 PAS fold; Region: PAS; pfam00989
526225002848 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199
526225002849 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
526225002850 metal binding site [ion binding]; metal-binding site
526225002851 active site
526225002852 I-site; other site
526225002853 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
526225002854 peptide chain release factor 2; Validated; Region: prfB; PRK00578
526225002855 This domain is found in peptide chain release factors; Region: PCRF; smart00937
526225002856 RF-1 domain; Region: RF-1; pfam00472
526225002857 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
526225002858 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225002859 Walker A/P-loop; other site
526225002860 ATP binding site [chemical binding]; other site
526225002861 Q-loop/lid; other site
526225002862 ABC transporter signature motif; other site
526225002863 Walker B; other site
526225002864 D-loop; other site
526225002865 H-loop/switch region; other site
526225002866 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
526225002867 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
526225002868 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
526225002869 SmpB-tmRNA interface; other site
526225002870 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
526225002871 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
526225002872 putative NAD(P) binding site [chemical binding]; other site
526225002873 Amidohydrolase; Region: Amidohydro_4; pfam13147
526225002874 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
526225002875 active site
526225002876 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
526225002877 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
526225002878 TAP-like protein; Region: Abhydrolase_4; pfam08386
526225002879 mycothiol synthase; Region: mycothiol_MshD; TIGR03448
526225002880 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
526225002881 active site
526225002882 Uncharacterized conserved protein [Function unknown]; Region: COG2128
526225002883 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
526225002884 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
526225002885 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
526225002886 oligomer interface [polypeptide binding]; other site
526225002887 metal binding site [ion binding]; metal-binding site
526225002888 metal binding site [ion binding]; metal-binding site
526225002889 putative Cl binding site [ion binding]; other site
526225002890 basic sphincter; other site
526225002891 hydrophobic gate; other site
526225002892 periplasmic entrance; other site
526225002893 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
526225002894 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
526225002895 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254
526225002896 N-acetyl-D-glucosamine binding site [chemical binding]; other site
526225002897 catalytic residue [active]
526225002898 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
526225002899 PAS fold; Region: PAS_3; pfam08447
526225002900 putative active site [active]
526225002901 heme pocket [chemical binding]; other site
526225002902 PAS domain; Region: PAS_9; pfam13426
526225002903 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
526225002904 putative active site [active]
526225002905 heme pocket [chemical binding]; other site
526225002906 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
526225002907 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
526225002908 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
526225002909 Ion channel; Region: Ion_trans_2; pfam07885
526225002910 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
526225002911 TrkA-N domain; Region: TrkA_N; pfam02254
526225002912 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
526225002913 active site
526225002914 nucleophile elbow; other site
526225002915 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
526225002916 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
526225002917 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
526225002918 putative active site [active]
526225002919 catalytic site [active]
526225002920 putative metal binding site [ion binding]; other site
526225002921 TIR domain; Region: TIR_2; pfam13676
526225002922 AAA ATPase domain; Region: AAA_16; pfam13191
526225002923 NB-ARC domain; Region: NB-ARC; pfam00931
526225002924 Tetratricopeptide repeat; Region: TPR_12; pfam13424
526225002925 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
526225002926 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
526225002927 catalytic residues [active]
526225002928 MarR family; Region: MarR_2; pfam12802
526225002929 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526225002930 MarR family; Region: MarR_2; cl17246
526225002931 Uncharacterized conserved protein [Function unknown]; Region: COG2353
526225002932 hypothetical protein; Provisional; Region: PRK07236
526225002933 hypothetical protein; Provisional; Region: PRK07588
526225002934 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
526225002935 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
526225002936 G1 box; other site
526225002937 putative GEF interaction site [polypeptide binding]; other site
526225002938 GTP/Mg2+ binding site [chemical binding]; other site
526225002939 Switch I region; other site
526225002940 G2 box; other site
526225002941 G3 box; other site
526225002942 Switch II region; other site
526225002943 G4 box; other site
526225002944 G5 box; other site
526225002945 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
526225002946 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710
526225002947 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
526225002948 active site
526225002949 catalytic residues [active]
526225002950 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
526225002951 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225002952 NAD(P) binding site [chemical binding]; other site
526225002953 active site
526225002954 Predicted permeases [General function prediction only]; Region: COG0730
526225002955 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
526225002956 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526225002957 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526225002958 DNA binding residues [nucleotide binding]
526225002959 CopC domain; Region: CopC; pfam04234
526225002960 YtkA-like; Region: YtkA; pfam13115
526225002961 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
526225002962 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
526225002963 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
526225002964 Cu(I) binding site [ion binding]; other site
526225002965 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
526225002966 active site
526225002967 metal-binding site
526225002968 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
526225002969 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
526225002970 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
526225002971 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526225002972 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
526225002973 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
526225002974 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
526225002975 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
526225002976 Peptidase family M23; Region: Peptidase_M23; pfam01551
526225002977 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
526225002978 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
526225002979 Putative cyclase; Region: Cyclase; pfam04199
526225002980 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
526225002981 homotrimer interaction site [polypeptide binding]; other site
526225002982 putative active site [active]
526225002983 Predicted transcriptional regulators [Transcription]; Region: COG1733
526225002984 HxlR-like helix-turn-helix; Region: HxlR; pfam01638
526225002985 Muconolactone delta-isomerase; Region: MIase; pfam02426
526225002986 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438
526225002987 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
526225002988 active site
526225002989 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
526225002990 Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315
526225002991 active site
526225002992 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
526225002993 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526225002994 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
526225002995 dimerization interface [polypeptide binding]; other site
526225002996 substrate binding pocket [chemical binding]; other site
526225002997 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
526225002998 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
526225002999 iron-sulfur cluster [ion binding]; other site
526225003000 [2Fe-2S] cluster binding site [ion binding]; other site
526225003001 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
526225003002 putative alpha subunit interface [polypeptide binding]; other site
526225003003 putative active site [active]
526225003004 putative substrate binding site [chemical binding]; other site
526225003005 Fe binding site [ion binding]; other site
526225003006 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
526225003007 inter-subunit interface; other site
526225003008 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
526225003009 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526225003010 catalytic loop [active]
526225003011 iron binding site [ion binding]; other site
526225003012 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
526225003013 FAD binding pocket [chemical binding]; other site
526225003014 FAD binding motif [chemical binding]; other site
526225003015 phosphate binding motif [ion binding]; other site
526225003016 beta-alpha-beta structure motif; other site
526225003017 NAD binding pocket [chemical binding]; other site
526225003018 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
526225003019 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
526225003020 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937
526225003021 putative NAD(P) binding site [chemical binding]; other site
526225003022 active site
526225003023 AAA ATPase domain; Region: AAA_16; pfam13191
526225003024 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225003025 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225003026 DNA binding residues [nucleotide binding]
526225003027 dimerization interface [polypeptide binding]; other site
526225003028 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526225003029 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
526225003030 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
526225003031 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
526225003032 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
526225003033 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417
526225003034 GAF domain; Region: GAF_2; pfam13185
526225003035 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
526225003036 Sodium Bile acid symporter family; Region: SBF; cl17470
526225003037 Flagellar protein (FlbD); Region: FlbD; pfam06289
526225003038 Methyltransferase domain; Region: Methyltransf_12; pfam08242
526225003039 S-adenosylmethionine binding site [chemical binding]; other site
526225003040 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526225003041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225003042 active site
526225003043 phosphorylation site [posttranslational modification]
526225003044 intermolecular recognition site; other site
526225003045 dimerization interface [polypeptide binding]; other site
526225003046 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526225003047 DNA binding site [nucleotide binding]
526225003048 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
526225003049 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
526225003050 putative active site [active]
526225003051 heme pocket [chemical binding]; other site
526225003052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
526225003053 dimer interface [polypeptide binding]; other site
526225003054 phosphorylation site [posttranslational modification]
526225003055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225003056 ATP binding site [chemical binding]; other site
526225003057 Mg2+ binding site [ion binding]; other site
526225003058 G-X-G motif; other site
526225003059 Response regulator receiver domain; Region: Response_reg; pfam00072
526225003060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225003061 active site
526225003062 phosphorylation site [posttranslational modification]
526225003063 intermolecular recognition site; other site
526225003064 dimerization interface [polypeptide binding]; other site
526225003065 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
526225003066 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
526225003067 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
526225003068 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
526225003069 FAD binding pocket [chemical binding]; other site
526225003070 FAD binding motif [chemical binding]; other site
526225003071 phosphate binding motif [ion binding]; other site
526225003072 NAD binding pocket [chemical binding]; other site
526225003073 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
526225003074 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
526225003075 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
526225003076 Domain of unknown function (DUF385); Region: DUF385; pfam04075
526225003077 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785
526225003078 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
526225003079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225003080 NAD(P) binding site [chemical binding]; other site
526225003081 active site
526225003082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225003083 S-adenosylmethionine binding site [chemical binding]; other site
526225003084 Domain of unknown function (DU1801); Region: DUF1801; pfam08818
526225003085 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
526225003086 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
526225003087 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
526225003088 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
526225003089 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225003090 Walker A/P-loop; other site
526225003091 ATP binding site [chemical binding]; other site
526225003092 Q-loop/lid; other site
526225003093 ABC transporter signature motif; other site
526225003094 Walker B; other site
526225003095 D-loop; other site
526225003096 H-loop/switch region; other site
526225003097 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526225003098 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526225003099 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526225003100 active site
526225003101 catalytic tetrad [active]
526225003102 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
526225003103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225003104 putative substrate translocation pore; other site
526225003105 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
526225003106 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
526225003107 NAD binding site [chemical binding]; other site
526225003108 catalytic Zn binding site [ion binding]; other site
526225003109 structural Zn binding site [ion binding]; other site
526225003110 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
526225003111 Peptidase family M23; Region: Peptidase_M23; pfam01551
526225003112 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
526225003113 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
526225003114 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
526225003115 homotetramer interface [polypeptide binding]; other site
526225003116 active site
526225003117 metal binding site [ion binding]; metal-binding site
526225003118 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
526225003119 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
526225003120 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
526225003121 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
526225003122 D-pathway; other site
526225003123 Putative ubiquinol binding site [chemical binding]; other site
526225003124 Low-spin heme (heme b) binding site [chemical binding]; other site
526225003125 Putative water exit pathway; other site
526225003126 Binuclear center (heme o3/CuB) [ion binding]; other site
526225003127 K-pathway; other site
526225003128 Putative proton exit pathway; other site
526225003129 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
526225003130 phosphoserine phosphatase SerB; Region: serB; TIGR00338
526225003131 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526225003132 motif II; other site
526225003133 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
526225003134 Isochorismatase family; Region: Isochorismatase; pfam00857
526225003135 catalytic triad [active]
526225003136 metal binding site [ion binding]; metal-binding site
526225003137 conserved cis-peptide bond; other site
526225003138 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
526225003139 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
526225003140 active site
526225003141 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
526225003142 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
526225003143 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
526225003144 MPN+ (JAMM) motif; other site
526225003145 Zinc-binding site [ion binding]; other site
526225003146 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
526225003147 MoaE interaction surface [polypeptide binding]; other site
526225003148 MoeB interaction surface [polypeptide binding]; other site
526225003149 thiocarboxylated glycine; other site
526225003150 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
526225003151 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
526225003152 dimer interface [polypeptide binding]; other site
526225003153 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225003154 catalytic residue [active]
526225003155 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
526225003156 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
526225003157 nucleotide binding site [chemical binding]; other site
526225003158 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081
526225003159 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
526225003160 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
526225003161 catalytic triad [active]
526225003162 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
526225003163 ribonuclease PH; Reviewed; Region: rph; PRK00173
526225003164 Ribonuclease PH; Region: RNase_PH_bact; cd11362
526225003165 hexamer interface [polypeptide binding]; other site
526225003166 active site
526225003167 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
526225003168 active site
526225003169 dimerization interface [polypeptide binding]; other site
526225003170 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
526225003171 Domain of unknown function (DUF427); Region: DUF427; pfam04248
526225003172 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526225003173 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225003174 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
526225003175 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526225003176 catalytic core [active]
526225003177 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526225003178 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526225003179 active site
526225003180 catalytic tetrad [active]
526225003181 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526225003182 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526225003183 active site
526225003184 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
526225003185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225003186 NAD(P) binding site [chemical binding]; other site
526225003187 active site
526225003188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225003189 putative substrate translocation pore; other site
526225003190 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526225003191 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
526225003192 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
526225003193 active site
526225003194 metal binding site [ion binding]; metal-binding site
526225003195 nudix motif; other site
526225003196 TIGR03086 family protein; Region: TIGR03086
526225003197 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
526225003198 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
526225003199 NodB motif; other site
526225003200 active site
526225003201 catalytic site [active]
526225003202 metal binding site [ion binding]; metal-binding site
526225003203 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
526225003204 classical (c) SDRs; Region: SDR_c; cd05233
526225003205 NAD(P) binding site [chemical binding]; other site
526225003206 active site
526225003207 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
526225003208 dimerization interface [polypeptide binding]; other site
526225003209 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
526225003210 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526225003211 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353
526225003212 putative dimer interface [polypeptide binding]; other site
526225003213 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526225003214 Berberine and berberine like; Region: BBE; pfam08031
526225003215 stage V sporulation protein K; Region: spore_V_K; TIGR02881
526225003216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526225003217 Walker A motif; other site
526225003218 ATP binding site [chemical binding]; other site
526225003219 Walker B motif; other site
526225003220 arginine finger; other site
526225003221 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
526225003222 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
526225003223 catalytic residues [active]
526225003224 catalytic nucleophile [active]
526225003225 Presynaptic Site I dimer interface [polypeptide binding]; other site
526225003226 Synaptic Antiparallel dimer interface [polypeptide binding]; other site
526225003227 Synaptic Flat tetramer interface [polypeptide binding]; other site
526225003228 Synaptic Site I dimer interface [polypeptide binding]; other site
526225003229 DNA binding site [nucleotide binding]
526225003230 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
526225003231 DNA-binding interface [nucleotide binding]; DNA binding site
526225003232 putative lipid kinase; Reviewed; Region: PRK13057
526225003233 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526225003234 putative DNA binding site [nucleotide binding]; other site
526225003235 putative Zn2+ binding site [ion binding]; other site
526225003236 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
526225003237 putative hydrophobic ligand binding site [chemical binding]; other site
526225003238 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
526225003239 active site
526225003240 NTP binding site [chemical binding]; other site
526225003241 metal binding triad [ion binding]; metal-binding site
526225003242 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
526225003243 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526225003244 SnoaL-like domain; Region: SnoaL_2; pfam12680
526225003245 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
526225003246 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
526225003247 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
526225003248 TIR domain; Region: TIR_2; pfam13676
526225003249 NB-ARC domain; Region: NB-ARC; pfam00931
526225003250 Methyltransferase domain; Region: Methyltransf_23; pfam13489
526225003251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225003252 S-adenosylmethionine binding site [chemical binding]; other site
526225003253 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
526225003254 OsmC-like protein; Region: OsmC; pfam02566
526225003255 Transcriptional regulators [Transcription]; Region: MarR; COG1846
526225003256 Winged helix DNA-binding domain; Region: HTH_34; pfam13601
526225003257 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526225003258 non-specific DNA binding site [nucleotide binding]; other site
526225003259 salt bridge; other site
526225003260 sequence-specific DNA binding site [nucleotide binding]; other site
526225003261 RibD C-terminal domain; Region: RibD_C; cl17279
526225003262 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
526225003263 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526225003264 PAS fold; Region: PAS_2; pfam08446
526225003265 GAF domain; Region: GAF; pfam01590
526225003266 Phytochrome region; Region: PHY; pfam00360
526225003267 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
526225003268 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
526225003269 heme binding pocket [chemical binding]; other site
526225003270 heme ligand [chemical binding]; other site
526225003271 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526225003272 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225003273 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
526225003274 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
526225003275 Proline dehydrogenase; Region: Pro_dh; cl03282
526225003276 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
526225003277 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
526225003278 Glutamate binding site [chemical binding]; other site
526225003279 NAD binding site [chemical binding]; other site
526225003280 catalytic residues [active]
526225003281 Protein of unknown function, DUF488; Region: DUF488; pfam04343
526225003282 Methyltransferase domain; Region: Methyltransf_23; pfam13489
526225003283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225003284 S-adenosylmethionine binding site [chemical binding]; other site
526225003285 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
526225003286 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
526225003287 Walker A/P-loop; other site
526225003288 ATP binding site [chemical binding]; other site
526225003289 Q-loop/lid; other site
526225003290 ABC transporter signature motif; other site
526225003291 Walker B; other site
526225003292 D-loop; other site
526225003293 H-loop/switch region; other site
526225003294 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526225003295 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526225003296 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225003297 Ion channel; Region: Ion_trans_2; pfam07885
526225003298 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
526225003299 TrkA-N domain; Region: TrkA_N; pfam02254
526225003300 TrkA-N domain; Region: TrkA_N; pfam02254
526225003301 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355
526225003302 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526225003303 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526225003304 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
526225003305 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
526225003306 active site
526225003307 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
526225003308 intersubunit interface [polypeptide binding]; other site
526225003309 active site
526225003310 Zn2+ binding site [ion binding]; other site
526225003311 Transcriptional regulators [Transcription]; Region: PhnF; COG2188
526225003312 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526225003313 DNA-binding site [nucleotide binding]; DNA binding site
526225003314 UTRA domain; Region: UTRA; pfam07702
526225003315 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
526225003316 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207
526225003317 ribulose bisphosphate carboxylase, type III; Region: rubisco_III; TIGR03326
526225003318 dimer interface [polypeptide binding]; other site
526225003319 active site
526225003320 catalytic residue [active]
526225003321 metal binding site [ion binding]; metal-binding site
526225003322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
526225003323 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
526225003324 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
526225003325 NAD(P) binding site [chemical binding]; other site
526225003326 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
526225003327 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
526225003328 active site
526225003329 DNA binding site [nucleotide binding]
526225003330 Int/Topo IB signature motif; other site
526225003331 Helix-turn-helix domain; Region: HTH_17; pfam12728
526225003332 TrwC relaxase; Region: TrwC; pfam08751
526225003333 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
526225003334 AAA domain; Region: AAA_30; pfam13604
526225003335 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
526225003336 active site
526225003337 catalytic triad [active]
526225003338 oxyanion hole [active]
526225003339 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
526225003340 putative active site [active]
526225003341 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
526225003342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
526225003343 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
526225003344 VPS10 domain; Region: VPS10; smart00602
526225003345 Ubiquitin-like proteins; Region: UBQ; cl00155
526225003346 charged pocket; other site
526225003347 hydrophobic patch; other site
526225003348 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
526225003349 GAF domain; Region: GAF; pfam01590
526225003350 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
526225003351 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
526225003352 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
526225003353 catalytic site [active]
526225003354 putative active site [active]
526225003355 putative substrate binding site [chemical binding]; other site
526225003356 dimer interface [polypeptide binding]; other site
526225003357 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526225003358 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225003359 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
526225003360 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
526225003361 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
526225003362 Ferritin-like domain; Region: Ferritin; pfam00210
526225003363 ferroxidase diiron center [ion binding]; other site
526225003364 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
526225003365 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
526225003366 ATP-grasp domain; Region: ATP-grasp_4; cl17255
526225003367 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
526225003368 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
526225003369 carboxyltransferase (CT) interaction site; other site
526225003370 biotinylation site [posttranslational modification]; other site
526225003371 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526225003372 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526225003373 active site
526225003374 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
526225003375 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
526225003376 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
526225003377 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253
526225003378 NAD(P) binding site [chemical binding]; other site
526225003379 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
526225003380 dimer interface [polypeptide binding]; other site
526225003381 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526225003382 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305
526225003383 AAA ATPase domain; Region: AAA_16; pfam13191
526225003384 NACHT domain; Region: NACHT; pfam05729
526225003385 FO synthase; Reviewed; Region: fbiC; PRK09234
526225003386 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526225003387 FeS/SAM binding site; other site
526225003388 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526225003389 FeS/SAM binding site; other site
526225003390 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
526225003391 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
526225003392 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
526225003393 Walker A/P-loop; other site
526225003394 ATP binding site [chemical binding]; other site
526225003395 Q-loop/lid; other site
526225003396 ABC transporter signature motif; other site
526225003397 Walker B; other site
526225003398 D-loop; other site
526225003399 H-loop/switch region; other site
526225003400 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639
526225003401 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526225003402 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526225003403 DNA binding residues [nucleotide binding]
526225003404 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
526225003405 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
526225003406 dimer interface [polypeptide binding]; other site
526225003407 ADP-ribose binding site [chemical binding]; other site
526225003408 active site
526225003409 nudix motif; other site
526225003410 metal binding site [ion binding]; metal-binding site
526225003411 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
526225003412 active site
526225003413 catalytic triad [active]
526225003414 oxyanion hole [active]
526225003415 PAS domain S-box; Region: sensory_box; TIGR00229
526225003416 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
526225003417 putative active site [active]
526225003418 heme pocket [chemical binding]; other site
526225003419 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199
526225003420 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
526225003421 metal binding site [ion binding]; metal-binding site
526225003422 active site
526225003423 I-site; other site
526225003424 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
526225003425 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
526225003426 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027
526225003427 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
526225003428 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
526225003429 Mrr N-terminal domain; Region: Mrr_N; pfam14338
526225003430 Restriction endonuclease; Region: Mrr_cat; pfam04471
526225003431 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
526225003432 polymerase nucleotide-binding site; other site
526225003433 DNA-binding residues [nucleotide binding]; DNA binding site
526225003434 nucleotide binding site [chemical binding]; other site
526225003435 primase nucleotide-binding site [nucleotide binding]; other site
526225003436 AAA domain; Region: AAA_25; pfam13481
526225003437 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
526225003438 Walker A motif; other site
526225003439 ATP binding site [chemical binding]; other site
526225003440 Walker B motif; other site
526225003441 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
526225003442 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
526225003443 active site
526225003444 metal binding site [ion binding]; metal-binding site
526225003445 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
526225003446 active site
526225003447 Int/Topo IB signature motif; other site
526225003448 DNA binding site [nucleotide binding]
526225003449 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
526225003450 DNA binding site [nucleotide binding]
526225003451 active site
526225003452 Int/Topo IB signature motif; other site
526225003453 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
526225003454 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
526225003455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225003456 Response regulator receiver domain; Region: Response_reg; pfam00072
526225003457 active site
526225003458 phosphorylation site [posttranslational modification]
526225003459 intermolecular recognition site; other site
526225003460 dimerization interface [polypeptide binding]; other site
526225003461 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199
526225003462 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
526225003463 metal binding site [ion binding]; metal-binding site
526225003464 active site
526225003465 I-site; other site
526225003466 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
526225003467 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423
526225003468 DXD motif; other site
526225003469 Response regulator receiver domain; Region: Response_reg; pfam00072
526225003470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225003471 active site
526225003472 phosphorylation site [posttranslational modification]
526225003473 intermolecular recognition site; other site
526225003474 dimerization interface [polypeptide binding]; other site
526225003475 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
526225003476 GAF domain; Region: GAF; pfam01590
526225003477 PAS domain S-box; Region: sensory_box; TIGR00229
526225003478 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
526225003479 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
526225003480 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
526225003481 putative active site [active]
526225003482 heme pocket [chemical binding]; other site
526225003483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
526225003484 dimer interface [polypeptide binding]; other site
526225003485 phosphorylation site [posttranslational modification]
526225003486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225003487 ATP binding site [chemical binding]; other site
526225003488 Mg2+ binding site [ion binding]; other site
526225003489 G-X-G motif; other site
526225003490 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
526225003491 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
526225003492 dimer interface [polypeptide binding]; other site
526225003493 ssDNA binding site [nucleotide binding]; other site
526225003494 tetramer (dimer of dimers) interface [polypeptide binding]; other site
526225003495 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
526225003496 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526225003497 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526225003498 ABC transporter; Region: ABC_tran_2; pfam12848
526225003499 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526225003500 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
526225003501 active site
526225003502 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
526225003503 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
526225003504 hypothetical protein; Provisional; Region: PRK11770
526225003505 Domain of unknown function (DUF307); Region: DUF307; pfam03733
526225003506 Domain of unknown function (DUF307); Region: DUF307; pfam03733
526225003507 MOSC domain; Region: MOSC; pfam03473
526225003508 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
526225003509 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
526225003510 Walker A/P-loop; other site
526225003511 ATP binding site [chemical binding]; other site
526225003512 Q-loop/lid; other site
526225003513 ABC transporter signature motif; other site
526225003514 Walker B; other site
526225003515 D-loop; other site
526225003516 H-loop/switch region; other site
526225003517 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
526225003518 Roadblock/LC7 domain; Region: Robl_LC7; cl00886
526225003519 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
526225003520 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
526225003521 Walker A/P-loop; other site
526225003522 ATP binding site [chemical binding]; other site
526225003523 Q-loop/lid; other site
526225003524 ABC transporter signature motif; other site
526225003525 Walker B; other site
526225003526 D-loop; other site
526225003527 H-loop/switch region; other site
526225003528 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
526225003529 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
526225003530 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
526225003531 active site
526225003532 catalytic site [active]
526225003533 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
526225003534 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
526225003535 apolar tunnel; other site
526225003536 heme binding site [chemical binding]; other site
526225003537 dimerization interface [polypeptide binding]; other site
526225003538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225003539 H+ Antiporter protein; Region: 2A0121; TIGR00900
526225003540 putative substrate translocation pore; other site
526225003541 Mechanosensitive ion channel; Region: MS_channel; pfam00924
526225003542 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
526225003543 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
526225003544 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
526225003545 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
526225003546 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
526225003547 active site
526225003548 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
526225003549 active site
526225003550 catalytic site [active]
526225003551 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
526225003552 kynureninase; Region: kynureninase; TIGR01814
526225003553 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526225003554 catalytic residue [active]
526225003555 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
526225003556 Amidase; Region: Amidase; pfam01425
526225003557 Repair protein; Region: Repair_PSII; pfam04536
526225003558 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
526225003559 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
526225003560 Zn binding site [ion binding]; other site
526225003561 DSBA-like thioredoxin domain; Region: DSBA; pfam01323
526225003562 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
526225003563 catalytic residues [active]
526225003564 Protein of unknown function (DUF429); Region: DUF429; cl12046
526225003565 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
526225003566 hypothetical protein; Provisional; Region: PRK01346
526225003567 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526225003568 Coenzyme A binding pocket [chemical binding]; other site
526225003569 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869
526225003570 RNA polymerase sigma-70 factor, TIGR02960 family; Region: SigX5
526225003571 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526225003572 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526225003573 DNA binding residues [nucleotide binding]
526225003574 SnoaL-like domain; Region: SnoaL_2; pfam12680
526225003575 Transcriptional regulator [Transcription]; Region: LysR; COG0583
526225003576 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526225003577 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
526225003578 dimerization interface [polypeptide binding]; other site
526225003579 substrate binding pocket [chemical binding]; other site
526225003580 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
526225003581 EamA-like transporter family; Region: EamA; pfam00892
526225003582 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
526225003583 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292
526225003584 Ligand Binding Site [chemical binding]; other site
526225003585 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861
526225003586 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
526225003587 AIR carboxylase; Region: AIRC; smart01001
526225003588 hypothetical protein; Provisional; Region: PRK04194
526225003589 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526225003590 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
526225003591 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
526225003592 GAF domain; Region: GAF; pfam01590
526225003593 GAF domain; Region: GAF_2; pfam13185
526225003594 ANTAR domain; Region: ANTAR; pfam03861
526225003595 short chain dehydrogenase; Provisional; Region: PRK06180
526225003596 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
526225003597 NADP binding site [chemical binding]; other site
526225003598 active site
526225003599 steroid binding site; other site
526225003600 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526225003601 salt bridge; other site
526225003602 non-specific DNA binding site [nucleotide binding]; other site
526225003603 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526225003604 sequence-specific DNA binding site [nucleotide binding]; other site
526225003605 GAF domain; Region: GAF; pfam01590
526225003606 GAF domain; Region: GAF_2; pfam13185
526225003607 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
526225003608 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
526225003609 putative active site [active]
526225003610 heme pocket [chemical binding]; other site
526225003611 GAF domain; Region: GAF; cl17456
526225003612 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
526225003613 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
526225003614 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
526225003615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225003616 ATP binding site [chemical binding]; other site
526225003617 Mg2+ binding site [ion binding]; other site
526225003618 G-X-G motif; other site
526225003619 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
526225003620 intracellular protease, PfpI family; Region: PfpI; TIGR01382
526225003621 proposed catalytic triad [active]
526225003622 conserved cys residue [active]
526225003623 trigger factor; Provisional; Region: tig; PRK01490
526225003624 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
526225003625 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
526225003626 Clp protease; Region: CLP_protease; pfam00574
526225003627 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
526225003628 oligomer interface [polypeptide binding]; other site
526225003629 active site residues [active]
526225003630 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
526225003631 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
526225003632 oligomer interface [polypeptide binding]; other site
526225003633 active site residues [active]
526225003634 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
526225003635 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
526225003636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526225003637 Walker A motif; other site
526225003638 ATP binding site [chemical binding]; other site
526225003639 Walker B motif; other site
526225003640 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
526225003641 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
526225003642 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
526225003643 putative active site [active]
526225003644 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208
526225003645 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
526225003646 active site
526225003647 HIGH motif; other site
526225003648 nucleotide binding site [chemical binding]; other site
526225003649 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
526225003650 active site
526225003651 KMSKS motif; other site
526225003652 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
526225003653 tRNA binding surface [nucleotide binding]; other site
526225003654 anticodon binding site; other site
526225003655 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
526225003656 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
526225003657 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
526225003658 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
526225003659 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
526225003660 active site
526225003661 multimer interface [polypeptide binding]; other site
526225003662 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
526225003663 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
526225003664 B12 binding site [chemical binding]; other site
526225003665 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526225003666 FeS/SAM binding site; other site
526225003667 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
526225003668 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
526225003669 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
526225003670 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
526225003671 homodimer interface [polypeptide binding]; other site
526225003672 oligonucleotide binding site [chemical binding]; other site
526225003673 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
526225003674 50S ribosomal protein L21; Validated; Region: rplU; PRK05573
526225003675 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
526225003676 GTPase CgtA; Reviewed; Region: obgE; PRK12296
526225003677 GTP1/OBG; Region: GTP1_OBG; pfam01018
526225003678 Obg GTPase; Region: Obg; cd01898
526225003679 G1 box; other site
526225003680 GTP/Mg2+ binding site [chemical binding]; other site
526225003681 Switch I region; other site
526225003682 G2 box; other site
526225003683 G3 box; other site
526225003684 Switch II region; other site
526225003685 G4 box; other site
526225003686 G5 box; other site
526225003687 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
526225003688 gamma-glutamyl kinase; Provisional; Region: PRK05429
526225003689 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
526225003690 nucleotide binding site [chemical binding]; other site
526225003691 homotetrameric interface [polypeptide binding]; other site
526225003692 putative phosphate binding site [ion binding]; other site
526225003693 putative allosteric binding site; other site
526225003694 PUA domain; Region: PUA; pfam01472
526225003695 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
526225003696 active site
526225003697 catalytic residues [active]
526225003698 metal binding site [ion binding]; metal-binding site
526225003699 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
526225003700 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
526225003701 tetramer interface [polypeptide binding]; other site
526225003702 active site
526225003703 Mg2+/Mn2+ binding site [ion binding]; other site
526225003704 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
526225003705 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
526225003706 MarR family; Region: MarR_2; pfam12802
526225003707 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
526225003708 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
526225003709 putative active site [active]
526225003710 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
526225003711 metal binding site 2 [ion binding]; metal-binding site
526225003712 putative DNA binding helix; other site
526225003713 metal binding site 1 [ion binding]; metal-binding site
526225003714 dimer interface [polypeptide binding]; other site
526225003715 structural Zn2+ binding site [ion binding]; other site
526225003716 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
526225003717 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
526225003718 ABC-ATPase subunit interface; other site
526225003719 dimer interface [polypeptide binding]; other site
526225003720 putative PBP binding regions; other site
526225003721 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
526225003722 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225003723 Walker A/P-loop; other site
526225003724 ATP binding site [chemical binding]; other site
526225003725 Q-loop/lid; other site
526225003726 ABC transporter signature motif; other site
526225003727 Walker B; other site
526225003728 D-loop; other site
526225003729 H-loop/switch region; other site
526225003730 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
526225003731 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
526225003732 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
526225003733 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
526225003734 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
526225003735 putative catalytic cysteine [active]
526225003736 MoxR-like ATPases [General function prediction only]; Region: COG0714
526225003737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526225003738 Walker A motif; other site
526225003739 ATP binding site [chemical binding]; other site
526225003740 Walker B motif; other site
526225003741 arginine finger; other site
526225003742 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
526225003743 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
526225003744 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
526225003745 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
526225003746 active site
526225003747 (T/H)XGH motif; other site
526225003748 Oligomerisation domain; Region: Oligomerisation; pfam02410
526225003749 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526225003750 catalytic core [active]
526225003751 EDD domain protein, DegV family; Region: DegV; TIGR00762
526225003752 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
526225003753 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
526225003754 SLBB domain; Region: SLBB; pfam10531
526225003755 Helix-hairpin-helix motif; Region: HHH_3; pfam12836
526225003756 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
526225003757 hypothetical protein; Reviewed; Region: PRK07914
526225003758 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
526225003759 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
526225003760 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
526225003761 GTP-binding protein LepA; Provisional; Region: PRK05433
526225003762 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
526225003763 G1 box; other site
526225003764 putative GEF interaction site [polypeptide binding]; other site
526225003765 GTP/Mg2+ binding site [chemical binding]; other site
526225003766 Switch I region; other site
526225003767 G2 box; other site
526225003768 G3 box; other site
526225003769 Switch II region; other site
526225003770 G4 box; other site
526225003771 G5 box; other site
526225003772 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
526225003773 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
526225003774 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
526225003775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
526225003776 MOSC domain; Region: MOSC; pfam03473
526225003777 AAA ATPase domain; Region: AAA_16; pfam13191
526225003778 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225003779 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
526225003780 DNA binding residues [nucleotide binding]
526225003781 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
526225003782 FAD binding domain; Region: FAD_binding_4; pfam01565
526225003783 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
526225003784 FAD binding domain; Region: FAD_binding_4; pfam01565
526225003785 Clp amino terminal domain; Region: Clp_N; pfam02861
526225003786 Clp amino terminal domain; Region: Clp_N; pfam02861
526225003787 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
526225003788 putative deacylase active site [active]
526225003789 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
526225003790 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
526225003791 NAD(P) binding site [chemical binding]; other site
526225003792 selenophosphate synthetase; Provisional; Region: PRK00943
526225003793 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
526225003794 dimerization interface [polypeptide binding]; other site
526225003795 putative ATP binding site [chemical binding]; other site
526225003796 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
526225003797 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
526225003798 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
526225003799 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
526225003800 selenocysteine synthase; Provisional; Region: PRK04311
526225003801 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
526225003802 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
526225003803 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526225003804 catalytic residue [active]
526225003805 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
526225003806 G1 box; other site
526225003807 GTP/Mg2+ binding site [chemical binding]; other site
526225003808 G2 box; other site
526225003809 Switch I region; other site
526225003810 G3 box; other site
526225003811 Switch II region; other site
526225003812 G4 box; other site
526225003813 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
526225003814 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
526225003815 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
526225003816 pentamer interface [polypeptide binding]; other site
526225003817 dodecaamer interface [polypeptide binding]; other site
526225003818 enoyl-CoA hydratase; Provisional; Region: PRK07827
526225003819 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526225003820 substrate binding site [chemical binding]; other site
526225003821 oxyanion hole (OAH) forming residues; other site
526225003822 trimer interface [polypeptide binding]; other site
526225003823 coproporphyrinogen III oxidase; Validated; Region: PRK05628
526225003824 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526225003825 FeS/SAM binding site; other site
526225003826 HemN C-terminal domain; Region: HemN_C; pfam06969
526225003827 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
526225003828 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
526225003829 Walker A/P-loop; other site
526225003830 ATP binding site [chemical binding]; other site
526225003831 Q-loop/lid; other site
526225003832 ABC transporter signature motif; other site
526225003833 Walker B; other site
526225003834 D-loop; other site
526225003835 H-loop/switch region; other site
526225003836 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
526225003837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225003838 ATP binding site [chemical binding]; other site
526225003839 Mg2+ binding site [ion binding]; other site
526225003840 G-X-G motif; other site
526225003841 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225003842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225003843 active site
526225003844 phosphorylation site [posttranslational modification]
526225003845 intermolecular recognition site; other site
526225003846 dimerization interface [polypeptide binding]; other site
526225003847 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225003848 DNA binding residues [nucleotide binding]
526225003849 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
526225003850 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
526225003851 HTH domain; Region: HTH_11; pfam08279
526225003852 chaperone protein DnaJ; Provisional; Region: PRK14278
526225003853 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
526225003854 HSP70 interaction site [polypeptide binding]; other site
526225003855 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
526225003856 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
526225003857 dimer interface [polypeptide binding]; other site
526225003858 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
526225003859 Protein of unknown function (DUF418); Region: DUF418; pfam04235
526225003860 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526225003861 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225003862 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
526225003863 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
526225003864 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
526225003865 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225003866 Walker A/P-loop; other site
526225003867 ATP binding site [chemical binding]; other site
526225003868 Q-loop/lid; other site
526225003869 ABC transporter signature motif; other site
526225003870 Walker B; other site
526225003871 D-loop; other site
526225003872 H-loop/switch region; other site
526225003873 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
526225003874 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
526225003875 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
526225003876 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526225003877 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
526225003878 TM-ABC transporter signature motif; other site
526225003879 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
526225003880 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
526225003881 TM-ABC transporter signature motif; other site
526225003882 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
526225003883 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
526225003884 Walker A/P-loop; other site
526225003885 ATP binding site [chemical binding]; other site
526225003886 Q-loop/lid; other site
526225003887 ABC transporter signature motif; other site
526225003888 Walker B; other site
526225003889 D-loop; other site
526225003890 H-loop/switch region; other site
526225003891 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
526225003892 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
526225003893 Walker A/P-loop; other site
526225003894 ATP binding site [chemical binding]; other site
526225003895 Q-loop/lid; other site
526225003896 ABC transporter signature motif; other site
526225003897 Walker B; other site
526225003898 D-loop; other site
526225003899 H-loop/switch region; other site
526225003900 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
526225003901 nucleotide binding site/active site [active]
526225003902 HIT family signature motif; other site
526225003903 catalytic residue [active]
526225003904 TspO/MBR family; Region: TspO_MBR; cl01379
526225003905 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
526225003906 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526225003907 substrate binding site [chemical binding]; other site
526225003908 oxyanion hole (OAH) forming residues; other site
526225003909 trimer interface [polypeptide binding]; other site
526225003910 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
526225003911 PhoH-like protein; Region: PhoH; pfam02562
526225003912 metal-binding heat shock protein; Provisional; Region: PRK00016
526225003913 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
526225003914 Domain of unknown function DUF21; Region: DUF21; pfam01595
526225003915 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
526225003916 Transporter associated domain; Region: CorC_HlyC; smart01091
526225003917 GTPase Era; Reviewed; Region: era; PRK00089
526225003918 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
526225003919 G1 box; other site
526225003920 GTP/Mg2+ binding site [chemical binding]; other site
526225003921 Switch I region; other site
526225003922 G2 box; other site
526225003923 Switch II region; other site
526225003924 G3 box; other site
526225003925 G4 box; other site
526225003926 KH domain; Region: KH_2; pfam07650
526225003927 Recombination protein O N terminal; Region: RecO_N; pfam11967
526225003928 DNA repair protein RecO; Reviewed; Region: recO; PRK00085
526225003929 Recombination protein O C terminal; Region: RecO_C; pfam02565
526225003930 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
526225003931 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
526225003932 catalytic residue [active]
526225003933 putative FPP diphosphate binding site; other site
526225003934 putative FPP binding hydrophobic cleft; other site
526225003935 dimer interface [polypeptide binding]; other site
526225003936 putative IPP diphosphate binding site; other site
526225003937 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
526225003938 glycyl-tRNA synthetase; Provisional; Region: PRK04173
526225003939 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
526225003940 motif 1; other site
526225003941 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
526225003942 active site
526225003943 motif 2; other site
526225003944 motif 3; other site
526225003945 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
526225003946 anticodon binding site; other site
526225003947 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
526225003948 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
526225003949 putative active site [active]
526225003950 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
526225003951 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
526225003952 FMN binding site [chemical binding]; other site
526225003953 active site
526225003954 catalytic residues [active]
526225003955 substrate binding site [chemical binding]; other site
526225003956 pyruvate phosphate dikinase; Provisional; Region: PRK09279
526225003957 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
526225003958 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
526225003959 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
526225003960 Uncharacterized conserved protein [Function unknown]; Region: COG1434
526225003961 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
526225003962 putative active site [active]
526225003963 DNA primase; Validated; Region: dnaG; PRK05667
526225003964 CHC2 zinc finger; Region: zf-CHC2; pfam01807
526225003965 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
526225003966 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
526225003967 active site
526225003968 metal binding site [ion binding]; metal-binding site
526225003969 interdomain interaction site; other site
526225003970 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
526225003971 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
526225003972 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
526225003973 AAA ATPase domain; Region: AAA_16; pfam13191
526225003974 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225003975 DNA binding residues [nucleotide binding]
526225003976 dimerization interface [polypeptide binding]; other site
526225003977 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329
526225003978 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
526225003979 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225003980 Walker A/P-loop; other site
526225003981 ATP binding site [chemical binding]; other site
526225003982 Q-loop/lid; other site
526225003983 ABC transporter signature motif; other site
526225003984 Walker B; other site
526225003985 D-loop; other site
526225003986 H-loop/switch region; other site
526225003987 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329
526225003988 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
526225003989 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
526225003990 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
526225003991 DNA binding site [nucleotide binding]
526225003992 Bacterial transcriptional activator domain; Region: BTAD; pfam03704
526225003993 Predicted ATPase [General function prediction only]; Region: COG3903
526225003994 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329
526225003995 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
526225003996 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
526225003997 putative NAD(P) binding site [chemical binding]; other site
526225003998 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
526225003999 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526225004000 catalytic core [active]
526225004001 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
526225004002 putative homotetramer interface [polypeptide binding]; other site
526225004003 putative homodimer interface [polypeptide binding]; other site
526225004004 putative allosteric switch controlling residues; other site
526225004005 putative metal binding site [ion binding]; other site
526225004006 putative homodimer-homodimer interface [polypeptide binding]; other site
526225004007 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
526225004008 metal-binding site [ion binding]
526225004009 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
526225004010 NADH dehydrogenase; Region: NADHdh; cl00469
526225004011 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
526225004012 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
526225004013 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
526225004014 NRDE protein; Region: NRDE; cl01315
526225004015 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
526225004016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225004017 Walker A/P-loop; other site
526225004018 ATP binding site [chemical binding]; other site
526225004019 Q-loop/lid; other site
526225004020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225004021 ABC transporter signature motif; other site
526225004022 Walker B; other site
526225004023 D-loop; other site
526225004024 H-loop/switch region; other site
526225004025 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225004026 Walker A/P-loop; other site
526225004027 ATP binding site [chemical binding]; other site
526225004028 Q-loop/lid; other site
526225004029 ABC transporter signature motif; other site
526225004030 Walker B; other site
526225004031 D-loop; other site
526225004032 H-loop/switch region; other site
526225004033 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
526225004034 tryptophan synthase, beta subunit; Region: trpB; TIGR00263
526225004035 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225004036 catalytic residue [active]
526225004037 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
526225004038 tetramerization interface [polypeptide binding]; other site
526225004039 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
526225004040 NAD(P) binding site [chemical binding]; other site
526225004041 catalytic residues [active]
526225004042 BCCT family transporter; Region: BCCT; cl00569
526225004043 choline dehydrogenase; Validated; Region: PRK02106
526225004044 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
526225004045 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_3; cd12160
526225004046 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
526225004047 putative ligand binding site [chemical binding]; other site
526225004048 putative NAD binding site [chemical binding]; other site
526225004049 catalytic site [active]
526225004050 Transcriptional regulators [Transcription]; Region: GntR; COG1802
526225004051 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526225004052 DNA-binding site [nucleotide binding]; DNA binding site
526225004053 FCD domain; Region: FCD; pfam07729
526225004054 fructuronate transporter; Provisional; Region: PRK10034; cl15264
526225004055 fructuronate transporter; Provisional; Region: PRK10034; cl15264
526225004056 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
526225004057 TPP-binding site [chemical binding]; other site
526225004058 dimer interface [polypeptide binding]; other site
526225004059 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
526225004060 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
526225004061 PYR/PP interface [polypeptide binding]; other site
526225004062 dimer interface [polypeptide binding]; other site
526225004063 TPP binding site [chemical binding]; other site
526225004064 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
526225004065 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
526225004066 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225004067 NAD(P) binding site [chemical binding]; other site
526225004068 active site
526225004069 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
526225004070 classical (c) SDRs; Region: SDR_c; cd05233
526225004071 NAD(P) binding site [chemical binding]; other site
526225004072 active site
526225004073 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
526225004074 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
526225004075 NAD(P) binding site [chemical binding]; other site
526225004076 catalytic residues [active]
526225004077 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
526225004078 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
526225004079 tetrameric interface [polypeptide binding]; other site
526225004080 NAD binding site [chemical binding]; other site
526225004081 catalytic residues [active]
526225004082 substrate binding site [chemical binding]; other site
526225004083 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
526225004084 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
526225004085 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
526225004086 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
526225004087 inhibitor-cofactor binding pocket; inhibition site
526225004088 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225004089 catalytic residue [active]
526225004090 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
526225004091 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
526225004092 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
526225004093 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526225004094 putative DNA binding site [nucleotide binding]; other site
526225004095 putative Zn2+ binding site [ion binding]; other site
526225004096 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
526225004097 agmatinase; Region: agmatinase; TIGR01230
526225004098 oligomer interface [polypeptide binding]; other site
526225004099 putative active site [active]
526225004100 Mn binding site [ion binding]; other site
526225004101 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
526225004102 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526225004103 non-specific DNA binding site [nucleotide binding]; other site
526225004104 salt bridge; other site
526225004105 sequence-specific DNA binding site [nucleotide binding]; other site
526225004106 Cupin domain; Region: Cupin_2; pfam07883
526225004107 amino acid transporter; Region: 2A0306; TIGR00909
526225004108 C-terminus of AA_permease; Region: AA_permease_C; pfam13906
526225004109 Predicted amidohydrolase [General function prediction only]; Region: COG0388
526225004110 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576
526225004111 putative active site [active]
526225004112 catalytic triad [active]
526225004113 putative dimer interface [polypeptide binding]; other site
526225004114 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526225004115 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
526225004116 Acetyltransferases [General function prediction only]; Region: RimI; COG0456
526225004117 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526225004118 Coenzyme A binding pocket [chemical binding]; other site
526225004119 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
526225004120 active site
526225004121 ATP binding site [chemical binding]; other site
526225004122 Phosphotransferase enzyme family; Region: APH; pfam01636
526225004123 substrate binding site [chemical binding]; other site
526225004124 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526225004125 dimerization interface [polypeptide binding]; other site
526225004126 putative DNA binding site [nucleotide binding]; other site
526225004127 putative Zn2+ binding site [ion binding]; other site
526225004128 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
526225004129 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
526225004130 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
526225004131 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526225004132 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
526225004133 active site
526225004134 metal binding site [ion binding]; metal-binding site
526225004135 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
526225004136 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526225004137 substrate binding site [chemical binding]; other site
526225004138 oxyanion hole (OAH) forming residues; other site
526225004139 trimer interface [polypeptide binding]; other site
526225004140 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526225004141 tyramine oxidase; Provisional; Region: tynA; PRK11504
526225004142 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
526225004143 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
526225004144 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
526225004145 agmatinase; Region: agmatinase; TIGR01230
526225004146 Agmatinase-like family; Region: Agmatinase-like; cd09990
526225004147 active site
526225004148 oligomer interface [polypeptide binding]; other site
526225004149 Mn binding site [ion binding]; other site
526225004150 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
526225004151 MMPL family; Region: MMPL; pfam03176
526225004152 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225004153 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526225004154 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
526225004155 Amidohydrolase; Region: Amidohydro_2; pfam04909
526225004156 Domain of unknown function DUF59; Region: DUF59; pfam01883
526225004157 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
526225004158 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284
526225004159 NAD binding site [chemical binding]; other site
526225004160 substrate binding site [chemical binding]; other site
526225004161 catalytic Zn binding site [ion binding]; other site
526225004162 structural Zn binding site [ion binding]; other site
526225004163 pyruvate carboxylase; Reviewed; Region: PRK12999
526225004164 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
526225004165 ATP-grasp domain; Region: ATP-grasp_4; cl17255
526225004166 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
526225004167 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
526225004168 active site
526225004169 catalytic residues [active]
526225004170 metal binding site [ion binding]; metal-binding site
526225004171 homodimer binding site [polypeptide binding]; other site
526225004172 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
526225004173 carboxyltransferase (CT) interaction site; other site
526225004174 biotinylation site [posttranslational modification]; other site
526225004175 Protein Kinases, catalytic domain; Region: PKc_like; cl09925
526225004176 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526225004177 active site
526225004178 ATP binding site [chemical binding]; other site
526225004179 substrate binding site [chemical binding]; other site
526225004180 activation loop (A-loop); other site
526225004181 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
526225004182 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
526225004183 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
526225004184 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
526225004185 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
526225004186 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
526225004187 Cysteine-rich domain; Region: CCG; pfam02754
526225004188 Cysteine-rich domain; Region: CCG; pfam02754
526225004189 Transcriptional regulators [Transcription]; Region: PurR; COG1609
526225004190 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
526225004191 DNA binding site [nucleotide binding]
526225004192 domain linker motif; other site
526225004193 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
526225004194 dimerization interface [polypeptide binding]; other site
526225004195 ligand binding site [chemical binding]; other site
526225004196 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
526225004197 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
526225004198 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
526225004199 AAA domain; Region: AAA_33; pfam13671
526225004200 beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753
526225004201 beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753
526225004202 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
526225004203 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
526225004204 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
526225004205 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
526225004206 active site residue [active]
526225004207 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
526225004208 active site residue [active]
526225004209 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199
526225004210 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
526225004211 metal binding site [ion binding]; metal-binding site
526225004212 active site
526225004213 I-site; other site
526225004214 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
526225004215 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
526225004216 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
526225004217 NAD binding site [chemical binding]; other site
526225004218 catalytic Zn binding site [ion binding]; other site
526225004219 structural Zn binding site [ion binding]; other site
526225004220 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
526225004221 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
526225004222 active site
526225004223 catalytic site [active]
526225004224 metal binding site [ion binding]; metal-binding site
526225004225 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457
526225004226 putative active site [active]
526225004227 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
526225004228 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
526225004229 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
526225004230 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
526225004231 active site
526225004232 nucleophile elbow; other site
526225004233 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
526225004234 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
526225004235 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225004236 homodimer interface [polypeptide binding]; other site
526225004237 catalytic residue [active]
526225004238 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
526225004239 FAD binding domain; Region: FAD_binding_4; pfam01565
526225004240 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
526225004241 Cysteine-rich domain; Region: CCG; pfam02754
526225004242 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
526225004243 Transcriptional regulators [Transcription]; Region: MarR; COG1846
526225004244 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
526225004245 dimer interface [polypeptide binding]; other site
526225004246 substrate binding site [chemical binding]; other site
526225004247 metal binding sites [ion binding]; metal-binding site
526225004248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225004249 NADH(P)-binding; Region: NAD_binding_10; pfam13460
526225004250 NAD(P) binding site [chemical binding]; other site
526225004251 active site
526225004252 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
526225004253 active site
526225004254 catalytic site [active]
526225004255 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
526225004256 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386
526225004257 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526225004258 catalytic loop [active]
526225004259 iron binding site [ion binding]; other site
526225004260 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803
526225004261 L-aspartate oxidase; Provisional; Region: PRK06175
526225004262 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
526225004263 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
526225004264 catalytic triad [active]
526225004265 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
526225004266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225004267 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
526225004268 Thioredoxin; Region: Thioredoxin_4; pfam13462
526225004269 DSBA-like thioredoxin domain; Region: DSBA; pfam01323
526225004270 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
526225004271 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
526225004272 ligand binding site [chemical binding]; other site
526225004273 flexible hinge region; other site
526225004274 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
526225004275 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
526225004276 active site
526225004277 catalytic site [active]
526225004278 metal binding site [ion binding]; metal-binding site
526225004279 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
526225004280 anti sigma factor interaction site; other site
526225004281 regulatory phosphorylation site [posttranslational modification]; other site
526225004282 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
526225004283 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526225004284 acyl-coenzyme A oxidase; Region: PLN02526
526225004285 active site
526225004286 Ion channel; Region: Ion_trans_2; pfam07885
526225004287 TrkA-N domain; Region: TrkA_N; pfam02254
526225004288 Protein of unknown function (DUF664); Region: DUF664; pfam04978
526225004289 DinB superfamily; Region: DinB_2; pfam12867
526225004290 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526225004291 Catalytic domain of Protein Kinases; Region: PKc; cd00180
526225004292 active site
526225004293 ATP binding site [chemical binding]; other site
526225004294 substrate binding site [chemical binding]; other site
526225004295 activation loop (A-loop); other site
526225004296 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
526225004297 Ligand Binding Site [chemical binding]; other site
526225004298 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
526225004299 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
526225004300 amino acid transporter; Region: 2A0306; TIGR00909
526225004301 C-terminus of AA_permease; Region: AA_permease_C; pfam13906
526225004302 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
526225004303 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314
526225004304 acyl-activating enzyme (AAE) consensus motif; other site
526225004305 putative AMP binding site [chemical binding]; other site
526225004306 putative active site [active]
526225004307 putative CoA binding site [chemical binding]; other site
526225004308 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
526225004309 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
526225004310 active site
526225004311 NAD binding site [chemical binding]; other site
526225004312 metal binding site [ion binding]; metal-binding site
526225004313 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
526225004314 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
526225004315 CoenzymeA binding site [chemical binding]; other site
526225004316 subunit interaction site [polypeptide binding]; other site
526225004317 PHB binding site; other site
526225004318 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
526225004319 Part of AAA domain; Region: AAA_19; pfam13245
526225004320 Family description; Region: UvrD_C_2; pfam13538
526225004321 Methyltransferase domain; Region: Methyltransf_31; pfam13847
526225004322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225004323 S-adenosylmethionine binding site [chemical binding]; other site
526225004324 cytokinin dehydrogenase; Region: PLN02441
526225004325 FAD binding domain; Region: FAD_binding_4; pfam01565
526225004326 Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265
526225004327 O-methyltransferase; Region: Methyltransf_2; pfam00891
526225004328 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
526225004329 Putative lysophospholipase; Region: Hydrolase_4; pfam12146
526225004330 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
526225004331 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
526225004332 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285
526225004333 tetramer interface [polypeptide binding]; other site
526225004334 catalytic Zn binding site [ion binding]; other site
526225004335 NADP binding site [chemical binding]; other site
526225004336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225004337 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
526225004338 NAD(P) binding site [chemical binding]; other site
526225004339 active site
526225004340 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
526225004341 hypothetical protein; Validated; Region: PRK07581
526225004342 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
526225004343 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
526225004344 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
526225004345 EthD domain; Region: EthD; cl17553
526225004346 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
526225004347 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
526225004348 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
526225004349 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
526225004350 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
526225004351 putative hydrophobic ligand binding site [chemical binding]; other site
526225004352 protein interface [polypeptide binding]; other site
526225004353 gate; other site
526225004354 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
526225004355 Beta-lactamase; Region: Beta-lactamase; pfam00144
526225004356 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
526225004357 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
526225004358 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
526225004359 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
526225004360 active site 2 [active]
526225004361 active site 1 [active]
526225004362 Quinone oxidoreductase (QOR); Region: QOR1; cd08241
526225004363 NAD(P) binding site [chemical binding]; other site
526225004364 Enoylreductase; Region: PKS_ER; smart00829
526225004365 Transposase, Mutator family; Region: Transposase_mut; pfam00872
526225004366 MULE transposase domain; Region: MULE; pfam10551
526225004367 Lsr2; Region: Lsr2; pfam11774
526225004368 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
526225004369 Prostaglandin dehydrogenases; Region: PGDH; cd05288
526225004370 NAD(P) binding site [chemical binding]; other site
526225004371 substrate binding site [chemical binding]; other site
526225004372 dimer interface [polypeptide binding]; other site
526225004373 TIR domain; Region: TIR_2; pfam13676
526225004374 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
526225004375 active site
526225004376 Int/Topo IB signature motif; other site
526225004377 DNA binding site [nucleotide binding]
526225004378 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
526225004379 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
526225004380 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526225004381 Sigma-70 region 3; Region: Sigma70_r3; pfam04539
526225004382 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526225004383 DNA binding residues [nucleotide binding]
526225004384 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
526225004385 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
526225004386 nucleotide binding site [chemical binding]; other site
526225004387 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
526225004388 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
526225004389 active site
526225004390 dimerization interface [polypeptide binding]; other site
526225004391 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
526225004392 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
526225004393 putative active site [active]
526225004394 putative substrate binding site [chemical binding]; other site
526225004395 ATP binding site [chemical binding]; other site
526225004396 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
526225004397 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
526225004398 trimer interface [polypeptide binding]; other site
526225004399 active site
526225004400 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
526225004401 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
526225004402 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
526225004403 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
526225004404 generic binding surface II; other site
526225004405 ssDNA binding site; other site
526225004406 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
526225004407 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
526225004408 TrkA-N domain; Region: TrkA_N; pfam02254
526225004409 TrkA-C domain; Region: TrkA_C; pfam02080
526225004410 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
526225004411 TrkA-N domain; Region: TrkA_N; pfam02254
526225004412 TrkA-C domain; Region: TrkA_C; pfam02080
526225004413 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
526225004414 TRAM domain; Region: TRAM; pfam01938
526225004415 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
526225004416 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
526225004417 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
526225004418 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
526225004419 TPP-binding site; other site
526225004420 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
526225004421 PYR/PP interface [polypeptide binding]; other site
526225004422 dimer interface [polypeptide binding]; other site
526225004423 TPP binding site [chemical binding]; other site
526225004424 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
526225004425 Domain of unknown function DUF77; Region: DUF77; pfam01910
526225004426 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526225004427 fatty oxidation complex, alpha subunit FadJ; Region: FadJ; TIGR02440
526225004428 substrate binding site [chemical binding]; other site
526225004429 oxyanion hole (OAH) forming residues; other site
526225004430 trimer interface [polypeptide binding]; other site
526225004431 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
526225004432 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
526225004433 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
526225004434 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
526225004435 dimer interface [polypeptide binding]; other site
526225004436 active site
526225004437 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
526225004438 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
526225004439 catalytic site [active]
526225004440 putative active site [active]
526225004441 putative substrate binding site [chemical binding]; other site
526225004442 Helicase and RNase D C-terminal; Region: HRDC; smart00341
526225004443 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
526225004444 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
526225004445 substrate binding site [chemical binding]; other site
526225004446 active site
526225004447 protoporphyrinogen oxidase; Reviewed; Region: PRK11883
526225004448 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526225004449 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
526225004450 methionine sulfoxide reductase B; Provisional; Region: PRK00222
526225004451 SelR domain; Region: SelR; pfam01641
526225004452 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
526225004453 DNA-binding site [nucleotide binding]; DNA binding site
526225004454 RNA-binding motif; other site
526225004455 YCII-related domain; Region: YCII; cl00999
526225004456 Predicted membrane protein [Function unknown]; Region: COG2261
526225004457 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
526225004458 active site
526225004459 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
526225004460 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
526225004461 FAD binding pocket [chemical binding]; other site
526225004462 FAD binding motif [chemical binding]; other site
526225004463 phosphate binding motif [ion binding]; other site
526225004464 beta-alpha-beta structure motif; other site
526225004465 NAD(p) ribose binding residues [chemical binding]; other site
526225004466 NAD binding pocket [chemical binding]; other site
526225004467 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
526225004468 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526225004469 catalytic loop [active]
526225004470 iron binding site [ion binding]; other site
526225004471 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
526225004472 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
526225004473 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
526225004474 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
526225004475 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
526225004476 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
526225004477 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
526225004478 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526225004479 acyl-activating enzyme (AAE) consensus motif; other site
526225004480 AMP binding site [chemical binding]; other site
526225004481 active site
526225004482 CoA binding site [chemical binding]; other site
526225004483 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526225004484 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225004485 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
526225004486 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
526225004487 substrate binding site [chemical binding]; other site
526225004488 dimer interface [polypeptide binding]; other site
526225004489 NADP binding site [chemical binding]; other site
526225004490 catalytic residues [active]
526225004491 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
526225004492 active site 2 [active]
526225004493 active site 1 [active]
526225004494 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
526225004495 Cytochrome P450; Region: p450; cl12078
526225004496 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
526225004497 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
526225004498 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
526225004499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225004500 metabolite-proton symporter; Region: 2A0106; TIGR00883
526225004501 putative substrate translocation pore; other site
526225004502 Transcriptional regulator [Transcription]; Region: IclR; COG1414
526225004503 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
526225004504 Bacterial transcriptional regulator; Region: IclR; pfam01614
526225004505 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
526225004506 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
526225004507 NAD(P) binding site [chemical binding]; other site
526225004508 catalytic residues [active]
526225004509 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266
526225004510 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
526225004511 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
526225004512 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
526225004513 FAD-dependent oxidoreductase; Provisional; Region: PRK08132
526225004514 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
526225004515 hydroxyglutarate oxidase; Provisional; Region: PRK11728
526225004516 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
526225004517 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225004518 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
526225004519 Amino acid permease; Region: AA_permease; pfam00324
526225004520 tyramine oxidase; Provisional; Region: tynA; PRK11504
526225004521 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
526225004522 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
526225004523 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
526225004524 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
526225004525 putative DNA binding site [nucleotide binding]; other site
526225004526 putative Zn2+ binding site [ion binding]; other site
526225004527 AsnC family; Region: AsnC_trans_reg; pfam01037
526225004528 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
526225004529 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
526225004530 dimer interface [polypeptide binding]; other site
526225004531 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
526225004532 active site
526225004533 Fe binding site [ion binding]; other site
526225004534 Uncharacterized conserved protein [Function unknown]; Region: COG2966
526225004535 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
526225004536 Protein of unknown function (DUF3815); Region: DUF3815; cl01118
526225004537 hypothetical protein; Provisional; Region: PRK06541
526225004538 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
526225004539 inhibitor-cofactor binding pocket; inhibition site
526225004540 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225004541 catalytic residue [active]
526225004542 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
526225004543 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
526225004544 hexamer interface [polypeptide binding]; other site
526225004545 ligand binding site [chemical binding]; other site
526225004546 putative active site [active]
526225004547 NAD(P) binding site [chemical binding]; other site
526225004548 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
526225004549 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526225004550 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
526225004551 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
526225004552 NAD(P) binding site [chemical binding]; other site
526225004553 catalytic residues [active]
526225004554 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
526225004555 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
526225004556 aldehyde dehydrogenase family 7 member; Region: PLN02315
526225004557 tetrameric interface [polypeptide binding]; other site
526225004558 NAD binding site [chemical binding]; other site
526225004559 catalytic residues [active]
526225004560 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
526225004561 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
526225004562 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
526225004563 nucleotide binding site [chemical binding]; other site
526225004564 TAP-like protein; Region: Abhydrolase_4; pfam08386
526225004565 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
526225004566 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
526225004567 active site
526225004568 DNA binding site [nucleotide binding]
526225004569 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
526225004570 DNA binding site [nucleotide binding]
526225004571 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
526225004572 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
526225004573 putative active site [active]
526225004574 hypothetical protein; Provisional; Region: PRK14059
526225004575 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
526225004576 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
526225004577 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
526225004578 catalytic site [active]
526225004579 active site
526225004580 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
526225004581 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
526225004582 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
526225004583 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225004584 Walker A/P-loop; other site
526225004585 ATP binding site [chemical binding]; other site
526225004586 Q-loop/lid; other site
526225004587 ABC transporter signature motif; other site
526225004588 Walker B; other site
526225004589 D-loop; other site
526225004590 H-loop/switch region; other site
526225004591 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
526225004592 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
526225004593 FtsX-like permease family; Region: FtsX; pfam02687
526225004594 Transglycosylase-like domain; Region: Transglycosylas; pfam06737
526225004595 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
526225004596 maltooligosyl trehalose synthase; Provisional; Region: PRK14511
526225004597 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
526225004598 active site
526225004599 catalytic site [active]
526225004600 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
526225004601 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
526225004602 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
526225004603 active site
526225004604 catalytic site [active]
526225004605 excinuclease ABC subunit B; Provisional; Region: PRK05298
526225004606 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526225004607 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526225004608 nucleotide binding region [chemical binding]; other site
526225004609 ATP-binding site [chemical binding]; other site
526225004610 Ultra-violet resistance protein B; Region: UvrB; pfam12344
526225004611 UvrB/uvrC motif; Region: UVR; pfam02151
526225004612 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
526225004613 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
526225004614 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
526225004615 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
526225004616 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
526225004617 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
526225004618 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
526225004619 classical (c) SDRs; Region: SDR_c; cd05233
526225004620 NAD(P) binding site [chemical binding]; other site
526225004621 active site
526225004622 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
526225004623 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
526225004624 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
526225004625 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
526225004626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225004627 NAD(P) binding site [chemical binding]; other site
526225004628 active site
526225004629 CAAX protease self-immunity; Region: Abi; pfam02517
526225004630 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
526225004631 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
526225004632 catalytic residues [active]
526225004633 catalytic nucleophile [active]
526225004634 Recombinase; Region: Recombinase; pfam07508
526225004635 CHC2 zinc finger; Region: zf-CHC2; cl17510
526225004636 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
526225004637 active site
526225004638 metal binding site [ion binding]; metal-binding site
526225004639 interdomain interaction site; other site
526225004640 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
526225004641 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526225004642 non-specific DNA binding site [nucleotide binding]; other site
526225004643 salt bridge; other site
526225004644 sequence-specific DNA binding site [nucleotide binding]; other site
526225004645 Histidine kinase; Region: HisKA_3; pfam07730
526225004646 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225004647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225004648 active site
526225004649 phosphorylation site [posttranslational modification]
526225004650 intermolecular recognition site; other site
526225004651 dimerization interface [polypeptide binding]; other site
526225004652 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225004653 DNA binding residues [nucleotide binding]
526225004654 dimerization interface [polypeptide binding]; other site
526225004655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225004656 Major Facilitator Superfamily; Region: MFS_1; pfam07690
526225004657 putative substrate translocation pore; other site
526225004658 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329
526225004659 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
526225004660 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
526225004661 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
526225004662 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329
526225004663 Bacterial transcriptional activator domain; Region: BTAD; pfam03704
526225004664 cyclase homology domain; Region: CHD; cd07302
526225004665 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
526225004666 nucleotidyl binding site; other site
526225004667 metal binding site [ion binding]; metal-binding site
526225004668 dimer interface [polypeptide binding]; other site
526225004669 Predicted ATPase [General function prediction only]; Region: COG3903
526225004670 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
526225004671 Bacterial transcriptional activator domain; Region: BTAD; pfam03704
526225004672 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
526225004673 cyclase homology domain; Region: CHD; cd07302
526225004674 dimer interface [polypeptide binding]; other site
526225004675 Predicted ATPase [General function prediction only]; Region: COG3903
526225004676 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
526225004677 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
526225004678 putative NAD(P) binding site [chemical binding]; other site
526225004679 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329
526225004680 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
526225004681 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
526225004682 DDE superfamily endonuclease; Region: DDE_4; cl17710
526225004683 Transcriptional regulators [Transcription]; Region: MarR; COG1846
526225004684 Winged helix DNA-binding domain; Region: HTH_27; pfam13463
526225004685 DoxX-like family; Region: DoxX_2; pfam13564
526225004686 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424
526225004687 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
526225004688 active site
526225004689 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
526225004690 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
526225004691 putative active site [active]
526225004692 metal binding site [ion binding]; metal-binding site
526225004693 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
526225004694 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
526225004695 NADP binding site [chemical binding]; other site
526225004696 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
526225004697 Histidine kinase; Region: HisKA_3; pfam07730
526225004698 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225004699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225004700 active site
526225004701 phosphorylation site [posttranslational modification]
526225004702 intermolecular recognition site; other site
526225004703 dimerization interface [polypeptide binding]; other site
526225004704 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225004705 DNA binding residues [nucleotide binding]
526225004706 dimerization interface [polypeptide binding]; other site
526225004707 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
526225004708 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
526225004709 Walker A/P-loop; other site
526225004710 ATP binding site [chemical binding]; other site
526225004711 Q-loop/lid; other site
526225004712 ABC transporter signature motif; other site
526225004713 Walker B; other site
526225004714 D-loop; other site
526225004715 H-loop/switch region; other site
526225004716 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
526225004717 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
526225004718 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
526225004719 Int/Topo IB signature motif; other site
526225004720 Helix-turn-helix domain; Region: HTH_17; pfam12728
526225004721 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
526225004722 AAA domain; Region: AAA_30; pfam13604
526225004723 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
526225004724 intersubunit interface [polypeptide binding]; other site
526225004725 active site
526225004726 Zn2+ binding site [ion binding]; other site
526225004727 Transcriptional regulators [Transcription]; Region: PhnF; COG2188
526225004728 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526225004729 DNA-binding site [nucleotide binding]; DNA binding site
526225004730 UTRA domain; Region: UTRA; pfam07702
526225004731 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
526225004732 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207
526225004733 ribulose bisphosphate carboxylase, type III; Region: rubisco_III; TIGR03326
526225004734 dimer interface [polypeptide binding]; other site
526225004735 active site
526225004736 catalytic residue [active]
526225004737 metal binding site [ion binding]; metal-binding site
526225004738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
526225004739 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
526225004740 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
526225004741 NAD(P) binding site [chemical binding]; other site
526225004742 Transposase; Region: DEDD_Tnp_IS110; pfam01548
526225004743 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
526225004744 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
526225004745 RibD C-terminal domain; Region: RibD_C; cl17279
526225004746 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
526225004747 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526225004748 active site
526225004749 metal binding site [ion binding]; metal-binding site
526225004750 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
526225004751 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
526225004752 amidase; Provisional; Region: PRK12470
526225004753 Amidase; Region: Amidase; cl11426
526225004754 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
526225004755 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
526225004756 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
526225004757 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
526225004758 Uncharacterized conserved protein [Function unknown]; Region: COG3268
526225004759 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
526225004760 Putative lysophospholipase; Region: Hydrolase_4; pfam12146
526225004761 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
526225004762 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
526225004763 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
526225004764 GIY-YIG motif/motif A; other site
526225004765 active site
526225004766 catalytic site [active]
526225004767 putative DNA binding site [nucleotide binding]; other site
526225004768 metal binding site [ion binding]; metal-binding site
526225004769 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
526225004770 Helix-hairpin-helix motif; Region: HHH; pfam00633
526225004771 helix-hairpin-helix signature motif; other site
526225004772 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
526225004773 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
526225004774 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
526225004775 putative substrate binding pocket [chemical binding]; other site
526225004776 dimer interface [polypeptide binding]; other site
526225004777 phosphate binding site [ion binding]; other site
526225004778 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
526225004779 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
526225004780 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
526225004781 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
526225004782 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
526225004783 Phosphoglycerate kinase; Region: PGK; pfam00162
526225004784 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
526225004785 substrate binding site [chemical binding]; other site
526225004786 hinge regions; other site
526225004787 ADP binding site [chemical binding]; other site
526225004788 catalytic site [active]
526225004789 triosephosphate isomerase; Provisional; Region: PRK14567
526225004790 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
526225004791 substrate binding site [chemical binding]; other site
526225004792 dimer interface [polypeptide binding]; other site
526225004793 catalytic triad [active]
526225004794 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506
526225004795 peptide binding site [polypeptide binding]; other site
526225004796 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
526225004797 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
526225004798 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
526225004799 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
526225004800 putative active site [active]
526225004801 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
526225004802 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
526225004803 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
526225004804 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
526225004805 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
526225004806 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533
526225004807 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
526225004808 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
526225004809 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
526225004810 putative active site [active]
526225004811 transaldolase; Provisional; Region: PRK03903
526225004812 catalytic residue [active]
526225004813 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
526225004814 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
526225004815 TPP-binding site [chemical binding]; other site
526225004816 dimer interface [polypeptide binding]; other site
526225004817 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
526225004818 PYR/PP interface [polypeptide binding]; other site
526225004819 dimer interface [polypeptide binding]; other site
526225004820 TPP binding site [chemical binding]; other site
526225004821 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
526225004822 protoheme IX farnesyltransferase; Provisional; Region: PRK04375
526225004823 UbiA prenyltransferase family; Region: UbiA; pfam01040
526225004824 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
526225004825 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
526225004826 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
526225004827 Clp amino terminal domain; Region: Clp_N; pfam02861
526225004828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526225004829 Walker A motif; other site
526225004830 ATP binding site [chemical binding]; other site
526225004831 Walker B motif; other site
526225004832 arginine finger; other site
526225004833 UvrB/uvrC motif; Region: UVR; pfam02151
526225004834 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526225004835 Walker A motif; other site
526225004836 ATP binding site [chemical binding]; other site
526225004837 Walker B motif; other site
526225004838 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
526225004839 Predicted transcriptional regulator [Transcription]; Region: COG2345
526225004840 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526225004841 putative DNA binding site [nucleotide binding]; other site
526225004842 putative Zn2+ binding site [ion binding]; other site
526225004843 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
526225004844 FeS assembly protein SufB; Region: sufB; TIGR01980
526225004845 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
526225004846 FeS assembly protein SufD; Region: sufD; TIGR01981
526225004847 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
526225004848 [2Fe-2S] cluster binding site [ion binding]; other site
526225004849 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
526225004850 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
526225004851 Walker A/P-loop; other site
526225004852 ATP binding site [chemical binding]; other site
526225004853 Q-loop/lid; other site
526225004854 ABC transporter signature motif; other site
526225004855 Walker B; other site
526225004856 D-loop; other site
526225004857 H-loop/switch region; other site
526225004858 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
526225004859 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
526225004860 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526225004861 catalytic residue [active]
526225004862 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
526225004863 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
526225004864 trimerization site [polypeptide binding]; other site
526225004865 active site
526225004866 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
526225004867 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
526225004868 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225004869 Walker A/P-loop; other site
526225004870 ATP binding site [chemical binding]; other site
526225004871 Q-loop/lid; other site
526225004872 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526225004873 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526225004874 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
526225004875 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526225004876 substrate binding site [chemical binding]; other site
526225004877 oxyanion hole (OAH) forming residues; other site
526225004878 trimer interface [polypeptide binding]; other site
526225004879 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
526225004880 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
526225004881 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225004882 Walker A/P-loop; other site
526225004883 ATP binding site [chemical binding]; other site
526225004884 Q-loop/lid; other site
526225004885 ABC transporter signature motif; other site
526225004886 Walker B; other site
526225004887 D-loop; other site
526225004888 H-loop/switch region; other site
526225004889 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
526225004890 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
526225004891 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
526225004892 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
526225004893 putative active site [active]
526225004894 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
526225004895 active site
526225004896 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
526225004897 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225004898 NAD(P) binding site [chemical binding]; other site
526225004899 active site
526225004900 aconitate hydratase; Provisional; Region: acnA; PRK12881
526225004901 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
526225004902 substrate binding site [chemical binding]; other site
526225004903 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
526225004904 ligand binding site [chemical binding]; other site
526225004905 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
526225004906 substrate binding site [chemical binding]; other site
526225004907 NAD-dependent deacetylase; Provisional; Region: PRK00481
526225004908 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
526225004909 NAD+ binding site [chemical binding]; other site
526225004910 substrate binding site [chemical binding]; other site
526225004911 Zn binding site [ion binding]; other site
526225004912 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
526225004913 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526225004914 acyl-activating enzyme (AAE) consensus motif; other site
526225004915 AMP binding site [chemical binding]; other site
526225004916 active site
526225004917 CoA binding site [chemical binding]; other site
526225004918 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
526225004919 NlpC/P60 family; Region: NLPC_P60; pfam00877
526225004920 MoxR-like ATPases [General function prediction only]; Region: COG0714
526225004921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526225004922 Walker A motif; other site
526225004923 ATP binding site [chemical binding]; other site
526225004924 Walker B motif; other site
526225004925 arginine finger; other site
526225004926 Protein of unknown function DUF58; Region: DUF58; pfam01882
526225004927 hypothetical protein; Provisional; Region: PRK13685
526225004928 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
526225004929 metal ion-dependent adhesion site (MIDAS); other site
526225004930 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
526225004931 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423
526225004932 DXD motif; other site
526225004933 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
526225004934 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
526225004935 Amidase; Region: Amidase; pfam01425
526225004936 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
526225004937 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
526225004938 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
526225004939 short chain dehydrogenase; Provisional; Region: PRK06180
526225004940 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
526225004941 NADP binding site [chemical binding]; other site
526225004942 active site
526225004943 steroid binding site; other site
526225004944 short chain dehydrogenase; Validated; Region: PRK08324
526225004945 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
526225004946 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
526225004947 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
526225004948 catalytic Zn binding site [ion binding]; other site
526225004949 NAD(P) binding site [chemical binding]; other site
526225004950 structural Zn binding site [ion binding]; other site
526225004951 Helix-turn-helix domain; Region: HTH_31; pfam13560
526225004952 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
526225004953 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
526225004954 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
526225004955 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
526225004956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225004957 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
526225004958 NAD(P) binding site [chemical binding]; other site
526225004959 active site
526225004960 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889
526225004961 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225004962 NAD(P) binding site [chemical binding]; other site
526225004963 active site
526225004964 ferrochelatase; Reviewed; Region: hemH; PRK00035
526225004965 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
526225004966 C-terminal domain interface [polypeptide binding]; other site
526225004967 active site
526225004968 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
526225004969 active site
526225004970 N-terminal domain interface [polypeptide binding]; other site
526225004971 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526225004972 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
526225004973 catalytic site [active]
526225004974 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
526225004975 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
526225004976 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
526225004977 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526225004978 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
526225004979 Sigma-70 region 3; Region: Sigma70_r3; pfam04539
526225004980 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526225004981 DNA binding residues [nucleotide binding]
526225004982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
526225004983 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
526225004984 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
526225004985 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
526225004986 anti sigma factor interaction site; other site
526225004987 regulatory phosphorylation site [posttranslational modification]; other site
526225004988 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
526225004989 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028
526225004990 active site
526225004991 DNA binding site [nucleotide binding]
526225004992 Int/Topo IB signature motif; other site
526225004993 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
526225004994 anti sigma factor interaction site; other site
526225004995 regulatory phosphorylation site [posttranslational modification]; other site
526225004996 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098
526225004997 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
526225004998 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
526225004999 putative DNA binding site [nucleotide binding]; other site
526225005000 putative homodimer interface [polypeptide binding]; other site
526225005001 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
526225005002 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
526225005003 active site
526225005004 DNA binding site [nucleotide binding]
526225005005 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
526225005006 DNA binding site [nucleotide binding]
526225005007 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
526225005008 nucleotide binding site [chemical binding]; other site
526225005009 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
526225005010 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
526225005011 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
526225005012 putative active site [active]
526225005013 putative substrate binding site [chemical binding]; other site
526225005014 putative cosubstrate binding site; other site
526225005015 catalytic site [active]
526225005016 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
526225005017 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
526225005018 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
526225005019 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
526225005020 metal binding site 2 [ion binding]; metal-binding site
526225005021 putative DNA binding helix; other site
526225005022 metal binding site 1 [ion binding]; metal-binding site
526225005023 dimer interface [polypeptide binding]; other site
526225005024 structural Zn2+ binding site [ion binding]; other site
526225005025 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
526225005026 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
526225005027 tetramer interface [polypeptide binding]; other site
526225005028 heme binding pocket [chemical binding]; other site
526225005029 Major Facilitator Superfamily; Region: MFS_1; pfam07690
526225005030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225005031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225005032 PAC2 family; Region: PAC2; pfam09754
526225005033 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
526225005034 Domain of unknown function DUF20; Region: UPF0118; pfam01594
526225005035 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
526225005036 Dienelactone hydrolase family; Region: DLH; pfam01738
526225005037 Ankyrin repeats (many copies); Region: Ank_4; pfam13637
526225005038 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
526225005039 Ankyrin repeats (many copies); Region: Ank_4; pfam13637
526225005040 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
526225005041 AAA domain; Region: AAA_33; pfam13671
526225005042 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
526225005043 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
526225005044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225005045 NAD(P) binding site [chemical binding]; other site
526225005046 active site
526225005047 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
526225005048 active site
526225005049 catalytic triad [active]
526225005050 oxyanion hole [active]
526225005051 CHAT domain; Region: CHAT; pfam12770
526225005052 Uncharacterized conserved protein [Function unknown]; Region: COG3391
526225005053 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
526225005054 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
526225005055 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
526225005056 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
526225005057 GAF domain; Region: GAF; pfam01590
526225005058 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225005059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225005060 active site
526225005061 phosphorylation site [posttranslational modification]
526225005062 intermolecular recognition site; other site
526225005063 dimerization interface [polypeptide binding]; other site
526225005064 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225005065 DNA binding residues [nucleotide binding]
526225005066 dimerization interface [polypeptide binding]; other site
526225005067 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
526225005068 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
526225005069 Mg2+ binding site [ion binding]; other site
526225005070 G-X-G motif; other site
526225005071 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
526225005072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225005073 putative substrate translocation pore; other site
526225005074 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
526225005075 N- and C-terminal domain interface [polypeptide binding]; other site
526225005076 active site
526225005077 catalytic site [active]
526225005078 metal binding site [ion binding]; metal-binding site
526225005079 carbohydrate binding site [chemical binding]; other site
526225005080 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
526225005081 ATP binding site [chemical binding]; other site
526225005082 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
526225005083 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
526225005084 active site
526225005085 FMN binding site [chemical binding]; other site
526225005086 substrate binding site [chemical binding]; other site
526225005087 3Fe-4S cluster binding site [ion binding]; other site
526225005088 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037
526225005089 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
526225005090 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
526225005091 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
526225005092 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254
526225005093 N-acetyl-D-glucosamine binding site [chemical binding]; other site
526225005094 catalytic residue [active]
526225005095 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834
526225005096 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
526225005097 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
526225005098 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293
526225005099 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834
526225005100 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
526225005101 hypothetical protein; Provisional; Region: PRK02237
526225005102 Predicted methyltransferase [General function prediction only]; Region: COG3897
526225005103 Protein of unknown function DUF72; Region: DUF72; pfam01904
526225005104 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526225005105 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
526225005106 active site
526225005107 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
526225005108 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
526225005109 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
526225005110 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
526225005111 GXWXG protein; Region: GXWXG; pfam14231
526225005112 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
526225005113 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
526225005114 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
526225005115 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
526225005116 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
526225005117 ligand binding site [chemical binding]; other site
526225005118 homodimer interface [polypeptide binding]; other site
526225005119 NAD(P) binding site [chemical binding]; other site
526225005120 trimer interface B [polypeptide binding]; other site
526225005121 trimer interface A [polypeptide binding]; other site
526225005122 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
526225005123 PAS domain; Region: PAS_9; pfam13426
526225005124 PAS domain S-box; Region: sensory_box; TIGR00229
526225005125 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
526225005126 putative active site [active]
526225005127 heme pocket [chemical binding]; other site
526225005128 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199
526225005129 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
526225005130 metal binding site [ion binding]; metal-binding site
526225005131 active site
526225005132 I-site; other site
526225005133 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
526225005134 HDOD domain; Region: HDOD; pfam08668
526225005135 Beta-lactamase; Region: Beta-lactamase; pfam00144
526225005136 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
526225005137 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
526225005138 Acyl-CoA dehydrogenase; Region: ACAD; cd00567
526225005139 active site
526225005140 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
526225005141 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526225005142 active site
526225005143 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
526225005144 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199
526225005145 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
526225005146 metal binding site [ion binding]; metal-binding site
526225005147 active site
526225005148 I-site; other site
526225005149 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
526225005150 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
526225005151 Transcriptional regulator [Transcription]; Region: IclR; COG1414
526225005152 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
526225005153 Bacterial transcriptional regulator; Region: IclR; pfam01614
526225005154 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
526225005155 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
526225005156 active site
526225005157 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
526225005158 heterodimer interface [polypeptide binding]; other site
526225005159 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
526225005160 active site
526225005161 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
526225005162 tetramer interface [polypeptide binding]; other site
526225005163 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
526225005164 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
526225005165 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
526225005166 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
526225005167 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
526225005168 active site
526225005169 dimer interface [polypeptide binding]; other site
526225005170 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
526225005171 dimer interface [polypeptide binding]; other site
526225005172 active site
526225005173 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
526225005174 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152
526225005175 NAD(P) binding site [chemical binding]; other site
526225005176 catalytic residues [active]
526225005177 cyanate transporter; Region: CynX; TIGR00896
526225005178 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
526225005179 Allophanate hydrolase subunit 1; Region: AHS1; smart00796
526225005180 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
526225005181 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787
526225005182 putative active site [active]
526225005183 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
526225005184 hypothetical protein; Provisional; Region: PRK05463
526225005185 argininosuccinate synthase; Validated; Region: PRK05370
526225005186 RibD C-terminal domain; Region: RibD_C; cl17279
526225005187 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
526225005188 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526225005189 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
526225005190 putative ADP-binding pocket [chemical binding]; other site
526225005191 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526225005192 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526225005193 Putative oxidoreductase C terminal; Region: ox_reductase_C; pfam08635
526225005194 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526225005195 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526225005196 Putative oxidoreductase C terminal; Region: ox_reductase_C; pfam08635
526225005197 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
526225005198 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
526225005199 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
526225005200 putative NAD(P) binding site [chemical binding]; other site
526225005201 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526225005202 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
526225005203 Protein of unknown function (DUF664); Region: DUF664; pfam04978
526225005204 Competence protein CoiA-like family; Region: CoiA; cl11541
526225005205 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
526225005206 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
526225005207 active site
526225005208 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
526225005209 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526225005210 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
526225005211 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
526225005212 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
526225005213 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526225005214 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
526225005215 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
526225005216 NAD(P) binding site [chemical binding]; other site
526225005217 catalytic residues [active]
526225005218 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
526225005219 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
526225005220 putative NAD(P) binding site [chemical binding]; other site
526225005221 pyridoxamine kinase; Validated; Region: PRK05756
526225005222 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
526225005223 pyridoxal binding site [chemical binding]; other site
526225005224 dimer interface [polypeptide binding]; other site
526225005225 ATP binding site [chemical binding]; other site
526225005226 tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406
526225005227 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
526225005228 active site
526225005229 HIGH motif; other site
526225005230 nucleotide binding site [chemical binding]; other site
526225005231 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
526225005232 active site
526225005233 KMSKS motif; other site
526225005234 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
526225005235 active site
526225005236 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
526225005237 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
526225005238 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
526225005239 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526225005240 Coenzyme A binding pocket [chemical binding]; other site
526225005241 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
526225005242 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
526225005243 B12 binding site [chemical binding]; other site
526225005244 cobalt ligand [ion binding]; other site
526225005245 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
526225005246 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
526225005247 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
526225005248 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
526225005249 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
526225005250 intersubunit interface [polypeptide binding]; other site
526225005251 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
526225005252 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
526225005253 heme-binding site [chemical binding]; other site
526225005254 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
526225005255 FAD binding pocket [chemical binding]; other site
526225005256 FAD binding motif [chemical binding]; other site
526225005257 phosphate binding motif [ion binding]; other site
526225005258 beta-alpha-beta structure motif; other site
526225005259 NAD binding pocket [chemical binding]; other site
526225005260 DivIVA domain; Region: DivI1A_domain; TIGR03544
526225005261 DivIVA protein; Region: DivIVA; pfam05103
526225005262 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
526225005263 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
526225005264 heme-binding site [chemical binding]; other site
526225005265 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
526225005266 FAD binding pocket [chemical binding]; other site
526225005267 FAD binding motif [chemical binding]; other site
526225005268 phosphate binding motif [ion binding]; other site
526225005269 beta-alpha-beta structure motif; other site
526225005270 NAD binding pocket [chemical binding]; other site
526225005271 Heme binding pocket [chemical binding]; other site
526225005272 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
526225005273 Beta-lactamase; Region: Beta-lactamase; pfam00144
526225005274 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
526225005275 CoA-transferase family III; Region: CoA_transf_3; pfam02515
526225005276 enoyl-CoA hydratase; Provisional; Region: PRK08252
526225005277 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526225005278 substrate binding site [chemical binding]; other site
526225005279 oxyanion hole (OAH) forming residues; other site
526225005280 trimer interface [polypeptide binding]; other site
526225005281 Uncharacterized conserved protein [Function unknown]; Region: COG2353
526225005282 Cysteine dioxygenase type I; Region: CDO_I; pfam05995
526225005283 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
526225005284 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
526225005285 Chromate transporter; Region: Chromate_transp; pfam02417
526225005286 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
526225005287 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
526225005288 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
526225005289 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
526225005290 Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480
526225005291 active site
526225005292 catalytic triad [active]
526225005293 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
526225005294 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
526225005295 anti sigma factor interaction site; other site
526225005296 regulatory phosphorylation site [posttranslational modification]; other site
526225005297 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
526225005298 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
526225005299 NAD binding site [chemical binding]; other site
526225005300 6-phosphofructokinase; Provisional; Region: PRK03202
526225005301 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
526225005302 active site
526225005303 ADP/pyrophosphate binding site [chemical binding]; other site
526225005304 dimerization interface [polypeptide binding]; other site
526225005305 allosteric effector site; other site
526225005306 fructose-1,6-bisphosphate binding site; other site
526225005307 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT
526225005308 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
526225005309 ATP-grasp domain; Region: ATP-grasp_4; cl17255
526225005310 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
526225005311 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
526225005312 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
526225005313 shikimate binding site; other site
526225005314 NAD(P) binding site [chemical binding]; other site
526225005315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225005316 metabolite-proton symporter; Region: 2A0106; TIGR00883
526225005317 putative substrate translocation pore; other site
526225005318 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526225005319 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225005320 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148
526225005321 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
526225005322 catalytic residues [active]
526225005323 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133
526225005324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
526225005325 active site
526225005326 phosphorylation site [posttranslational modification]
526225005327 intermolecular recognition site; other site
526225005328 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
526225005329 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
526225005330 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
526225005331 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
526225005332 ligand binding site [chemical binding]; other site
526225005333 flexible hinge region; other site
526225005334 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
526225005335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225005336 ATP binding site [chemical binding]; other site
526225005337 Mg2+ binding site [ion binding]; other site
526225005338 G-X-G motif; other site
526225005339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225005340 putative substrate translocation pore; other site
526225005341 Sodium:dicarboxylate symporter family; Region: SDF; cl00573
526225005342 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
526225005343 PAS domain; Region: PAS; smart00091
526225005344 PAS fold; Region: PAS; pfam00989
526225005345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225005346 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
526225005347 ATP binding site [chemical binding]; other site
526225005348 G-X-G motif; other site
526225005349 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
526225005350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225005351 active site
526225005352 phosphorylation site [posttranslational modification]
526225005353 intermolecular recognition site; other site
526225005354 dimerization interface [polypeptide binding]; other site
526225005355 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
526225005356 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
526225005357 FAD binding domain; Region: FAD_binding_4; pfam01565
526225005358 Berberine and berberine like; Region: BBE; pfam08031
526225005359 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526225005360 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
526225005361 catalytic site [active]
526225005362 oxaloacetate decarboxylase; Provisional; Region: PRK14040
526225005363 Transcriptional regulator [Transcription]; Region: LysR; COG0583
526225005364 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526225005365 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
526225005366 dimerization interface [polypeptide binding]; other site
526225005367 substrate binding pocket [chemical binding]; other site
526225005368 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
526225005369 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
526225005370 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
526225005371 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
526225005372 trimer interface [polypeptide binding]; other site
526225005373 putative metal binding site [ion binding]; other site
526225005374 ribonuclease Z; Reviewed; Region: PRK00055
526225005375 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
526225005376 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
526225005377 active site
526225005378 SUMO-1 interface [polypeptide binding]; other site
526225005379 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
526225005380 Predicted transcriptional regulators [Transcription]; Region: COG1733
526225005381 HxlR-like helix-turn-helix; Region: HxlR; pfam01638
526225005382 AzlC protein; Region: AzlC; pfam03591
526225005383 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
526225005384 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526225005385 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
526225005386 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
526225005387 DNA-binding site [nucleotide binding]; DNA binding site
526225005388 RNA-binding motif; other site
526225005389 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
526225005390 DNA-binding site [nucleotide binding]; DNA binding site
526225005391 RNA-binding motif; other site
526225005392 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
526225005393 DNA-binding site [nucleotide binding]; DNA binding site
526225005394 RNA-binding motif; other site
526225005395 YciI-like protein; Reviewed; Region: PRK12866
526225005396 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417
526225005397 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
526225005398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225005399 ATP binding site [chemical binding]; other site
526225005400 Mg2+ binding site [ion binding]; other site
526225005401 G-X-G motif; other site
526225005402 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
526225005403 ATP binding site [chemical binding]; other site
526225005404 putative Mg++ binding site [ion binding]; other site
526225005405 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526225005406 nucleotide binding region [chemical binding]; other site
526225005407 ATP-binding site [chemical binding]; other site
526225005408 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
526225005409 active site
526225005410 oxyanion hole [active]
526225005411 putative hydrolase; Provisional; Region: PRK11460
526225005412 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
526225005413 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
526225005414 Soluble P-type ATPase [General function prediction only]; Region: COG4087
526225005415 Helix-turn-helix domain; Region: HTH_18; pfam12833
526225005416 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526225005417 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
526225005418 TIGR03086 family protein; Region: TIGR03086
526225005419 Domain of unknown function (DUF336); Region: DUF336; cl01249
526225005420 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
526225005421 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225005422 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
526225005423 Walker A/P-loop; other site
526225005424 ATP binding site [chemical binding]; other site
526225005425 Q-loop/lid; other site
526225005426 ABC transporter signature motif; other site
526225005427 Walker B; other site
526225005428 D-loop; other site
526225005429 H-loop/switch region; other site
526225005430 ABC-2 type transporter; Region: ABC2_membrane; cl17235
526225005431 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
526225005432 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
526225005433 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
526225005434 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736
526225005435 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526225005436 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
526225005437 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331
526225005438 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
526225005439 active site
526225005440 catalytic site [active]
526225005441 amidophosphoribosyltransferase; Region: PLN02440
526225005442 CAAX protease self-immunity; Region: Abi; pfam02517
526225005443 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
526225005444 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
526225005445 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
526225005446 GAF domain; Region: GAF; pfam01590
526225005447 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
526225005448 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
526225005449 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
526225005450 active site
526225005451 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
526225005452 active site
526225005453 ornithine cyclodeaminase; Validated; Region: PRK06141
526225005454 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
526225005455 hydroxyproline-2-epimerase; Provisional; Region: PRK13971
526225005456 Proline racemase; Region: Pro_racemase; pfam05544
526225005457 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
526225005458 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
526225005459 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
526225005460 dimer interface [polypeptide binding]; other site
526225005461 putative anticodon binding site; other site
526225005462 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
526225005463 motif 1; other site
526225005464 dimer interface [polypeptide binding]; other site
526225005465 active site
526225005466 motif 2; other site
526225005467 motif 3; other site
526225005468 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
526225005469 Protein of unknown function (DUF461); Region: DUF461; pfam04314
526225005470 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
526225005471 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
526225005472 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
526225005473 active site
526225005474 catalytic site [active]
526225005475 Zn binding site [ion binding]; other site
526225005476 tetramer interface [polypeptide binding]; other site
526225005477 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
526225005478 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
526225005479 active site
526225005480 homotetramer interface [polypeptide binding]; other site
526225005481 homodimer interface [polypeptide binding]; other site
526225005482 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097
526225005483 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
526225005484 FAD binding pocket [chemical binding]; other site
526225005485 FAD binding motif [chemical binding]; other site
526225005486 phosphate binding motif [ion binding]; other site
526225005487 beta-alpha-beta structure motif; other site
526225005488 NAD binding pocket [chemical binding]; other site
526225005489 acyl-CoA synthetase; Validated; Region: PRK08162
526225005490 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
526225005491 acyl-activating enzyme (AAE) consensus motif; other site
526225005492 putative active site [active]
526225005493 AMP binding site [chemical binding]; other site
526225005494 putative CoA binding site [chemical binding]; other site
526225005495 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979
526225005496 putative TOMM peptide; Region: TOMM_nitrile_2; TIGR04351
526225005497 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
526225005498 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
526225005499 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
526225005500 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189
526225005501 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225005502 Walker A/P-loop; other site
526225005503 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225005504 Walker A/P-loop; other site
526225005505 ATP binding site [chemical binding]; other site
526225005506 ATP binding site [chemical binding]; other site
526225005507 Q-loop/lid; other site
526225005508 ABC transporter signature motif; other site
526225005509 Walker B; other site
526225005510 D-loop; other site
526225005511 RibD C-terminal domain; Region: RibD_C; cl17279
526225005512 RibD C-terminal domain; Region: RibD_C; cl17279
526225005513 Integrase core domain; Region: rve_3; cl15866
526225005514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225005515 putative substrate translocation pore; other site
526225005516 Major Facilitator Superfamily; Region: MFS_1; pfam07690
526225005517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225005518 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
526225005519 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
526225005520 glycogen branching enzyme; Provisional; Region: PRK14705
526225005521 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
526225005522 hypothetical protein; Provisional; Region: PRK07236
526225005523 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180
526225005524 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015
526225005525 active site
526225005526 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
526225005527 DNA binding site [nucleotide binding]
526225005528 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
526225005529 DAK2 domain; Region: Dak2; cl03685
526225005530 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
526225005531 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
526225005532 Protein of unknown function (DUF461); Region: DUF461; cl01071
526225005533 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526225005534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225005535 active site
526225005536 phosphorylation site [posttranslational modification]
526225005537 intermolecular recognition site; other site
526225005538 dimerization interface [polypeptide binding]; other site
526225005539 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526225005540 DNA binding site [nucleotide binding]
526225005541 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
526225005542 SpoOM protein; Region: Spo0M; pfam07070
526225005543 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526225005544 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
526225005545 active site
526225005546 putative substrate binding region [chemical binding]; other site
526225005547 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
526225005548 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
526225005549 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225005550 NAD(P) binding site [chemical binding]; other site
526225005551 active site
526225005552 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
526225005553 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
526225005554 TAP-like protein; Region: Abhydrolase_4; pfam08386
526225005555 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
526225005556 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
526225005557 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
526225005558 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
526225005559 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
526225005560 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
526225005561 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
526225005562 Quinone oxidoreductase (QOR); Region: QOR1; cd08241
526225005563 NAD(P) binding site [chemical binding]; other site
526225005564 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
526225005565 Putative lysophospholipase; Region: Hydrolase_4; pfam12146
526225005566 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
526225005567 Sucrose-6-phosphate phosphohydrolase C-terminal; Region: S6PP_C; pfam08472
526225005568 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
526225005569 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
526225005570 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
526225005571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225005572 acyl-CoA synthetase; Validated; Region: PRK08316
526225005573 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526225005574 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
526225005575 acyl-activating enzyme (AAE) consensus motif; other site
526225005576 putative AMP binding site [chemical binding]; other site
526225005577 putative active site [active]
526225005578 putative CoA binding site [chemical binding]; other site
526225005579 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
526225005580 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526225005581 acyl-activating enzyme (AAE) consensus motif; other site
526225005582 AMP binding site [chemical binding]; other site
526225005583 active site
526225005584 CoA binding site [chemical binding]; other site
526225005585 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526225005586 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526225005587 active site
526225005588 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
526225005589 E-class dimer interface [polypeptide binding]; other site
526225005590 P-class dimer interface [polypeptide binding]; other site
526225005591 active site
526225005592 Cu2+ binding site [ion binding]; other site
526225005593 Zn2+ binding site [ion binding]; other site
526225005594 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
526225005595 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
526225005596 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526225005597 acyl-coenzyme A oxidase; Region: PLN02526
526225005598 active site
526225005599 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
526225005600 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
526225005601 TAP-like protein; Region: Abhydrolase_4; pfam08386
526225005602 Methyltransferase domain; Region: Methyltransf_23; pfam13489
526225005603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225005604 S-adenosylmethionine binding site [chemical binding]; other site
526225005605 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
526225005606 Cytochrome P450; Region: p450; cl12078
526225005607 hypothetical protein; Provisional; Region: PRK06185
526225005608 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
526225005609 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
526225005610 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
526225005611 Ligand Binding Site [chemical binding]; other site
526225005612 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
526225005613 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
526225005614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
526225005615 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
526225005616 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526225005617 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
526225005618 dimerization interface [polypeptide binding]; other site
526225005619 5-dehydro-4-deoxyglucarate dehydratase; Provisional; Region: PRK03620
526225005620 N-acetylneuraminate lyase; Provisional; Region: PRK04147
526225005621 catalytic residue [active]
526225005622 glucarate dehydratase; Region: glucar-dehydr; TIGR03247
526225005623 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
526225005624 active site
526225005625 tetramer interface [polypeptide binding]; other site
526225005626 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
526225005627 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
526225005628 active site pocket [active]
526225005629 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
526225005630 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
526225005631 dimer interface [polypeptide binding]; other site
526225005632 NADP binding site [chemical binding]; other site
526225005633 catalytic residues [active]
526225005634 ATP-grasp domain; Region: ATP-grasp_4; cl17255
526225005635 Membrane transport protein; Region: Mem_trans; cl09117
526225005636 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
526225005637 FAD binding domain; Region: FAD_binding_4; pfam01565
526225005638 Berberine and berberine like; Region: BBE; pfam08031
526225005639 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
526225005640 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
526225005641 malate:quinone oxidoreductase; Validated; Region: PRK05257
526225005642 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
526225005643 FAD binding domain; Region: FAD_binding_4; pfam01565
526225005644 Transcription factor WhiB; Region: Whib; pfam02467
526225005645 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
526225005646 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
526225005647 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526225005648 Dyp-type peroxidase family; Region: Dyp_perox; cl01067
526225005649 Bacterial transcriptional activator domain; Region: BTAD; smart01043
526225005650 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
526225005651 Cytochrome P450; Region: p450; cl12078
526225005652 Uncharacterized conserved protein [Function unknown]; Region: COG4850
526225005653 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949
526225005654 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
526225005655 DNA-binding site [nucleotide binding]; DNA binding site
526225005656 RNA-binding motif; other site
526225005657 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
526225005658 catalytic residues [active]
526225005659 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
526225005660 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
526225005661 NAD(P) binding site [chemical binding]; other site
526225005662 homotetramer interface [polypeptide binding]; other site
526225005663 homodimer interface [polypeptide binding]; other site
526225005664 active site
526225005665 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
526225005666 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
526225005667 ATP-grasp domain; Region: ATP-grasp_4; cl17255
526225005668 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
526225005669 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
526225005670 carboxyltransferase (CT) interaction site; other site
526225005671 biotinylation site [posttranslational modification]; other site
526225005672 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326
526225005673 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
526225005674 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
526225005675 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
526225005676 active site
526225005677 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
526225005678 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094
526225005679 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
526225005680 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526225005681 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
526225005682 YCII-related domain; Region: YCII; cl00999
526225005683 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839
526225005684 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
526225005685 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
526225005686 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417
526225005687 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417
526225005688 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
526225005689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225005690 Mg2+ binding site [ion binding]; other site
526225005691 G-X-G motif; other site
526225005692 Transcriptional regulator [Transcription]; Region: IclR; COG1414
526225005693 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
526225005694 Bacterial transcriptional regulator; Region: IclR; pfam01614
526225005695 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
526225005696 active site
526225005697 intersubunit interface [polypeptide binding]; other site
526225005698 catalytic residue [active]
526225005699 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
526225005700 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
526225005701 phosphate binding site [ion binding]; other site
526225005702 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
526225005703 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
526225005704 substrate binding site [chemical binding]; other site
526225005705 ATP binding site [chemical binding]; other site
526225005706 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
526225005707 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
526225005708 inhibitor site; inhibition site
526225005709 active site
526225005710 dimer interface [polypeptide binding]; other site
526225005711 catalytic residue [active]
526225005712 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299
526225005713 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
526225005714 ligand binding site [chemical binding]; other site
526225005715 NAD binding site [chemical binding]; other site
526225005716 catalytic site [active]
526225005717 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
526225005718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225005719 NAD(P) binding site [chemical binding]; other site
526225005720 active site
526225005721 dihydroxy-acid dehydratase; Validated; Region: PRK06131
526225005722 Transcriptional regulator [Transcription]; Region: IclR; COG1414
526225005723 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
526225005724 Bacterial transcriptional regulator; Region: IclR; pfam01614
526225005725 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
526225005726 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
526225005727 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
526225005728 NAD(P) binding site [chemical binding]; other site
526225005729 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366
526225005730 short chain dehydrogenase; Provisional; Region: PRK06138
526225005731 classical (c) SDRs; Region: SDR_c; cd05233
526225005732 NAD(P) binding site [chemical binding]; other site
526225005733 active site
526225005734 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
526225005735 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
526225005736 active site
526225005737 dimer interface [polypeptide binding]; other site
526225005738 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
526225005739 LytTr DNA-binding domain; Region: LytTR; smart00850
526225005740 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
526225005741 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
526225005742 NAD binding site [chemical binding]; other site
526225005743 catalytic Zn binding site [ion binding]; other site
526225005744 structural Zn binding site [ion binding]; other site
526225005745 Actinobacterial PQQ system protein; Region: PQQ_MSMEG_3727; TIGR04339
526225005746 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
526225005747 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
526225005748 Trp docking motif [polypeptide binding]; other site
526225005749 active site
526225005750 PqqA family; Region: PqqA; cl15372
526225005751 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
526225005752 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
526225005753 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
526225005754 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
526225005755 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
526225005756 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526225005757 FeS/SAM binding site; other site
526225005758 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
526225005759 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
526225005760 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
526225005761 Domain of unknown function (DUF336); Region: DUF336; pfam03928
526225005762 amino acid transporter; Region: 2A0306; TIGR00909
526225005763 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
526225005764 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225005765 NAD(P) binding site [chemical binding]; other site
526225005766 active site
526225005767 haloalkane dehalogenase; Provisional; Region: PRK03592
526225005768 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526225005769 peptide synthase; Provisional; Region: PRK09274
526225005770 acyl-activating enzyme (AAE) consensus motif; other site
526225005771 AMP binding site [chemical binding]; other site
526225005772 active site
526225005773 CoA binding site [chemical binding]; other site
526225005774 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258
526225005775 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
526225005776 active site
526225005777 Recombination endonuclease VII; Region: Endonuclease_7; pfam02945
526225005778 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
526225005779 active site
526225005780 DNA binding site [nucleotide binding]
526225005781 Int/Topo IB signature motif; other site
526225005782 Putative lysophospholipase; Region: Hydrolase_4; pfam12146
526225005783 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
526225005784 Methyltransferase domain; Region: Methyltransf_24; pfam13578
526225005785 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
526225005786 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
526225005787 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
526225005788 ligand binding site [chemical binding]; other site
526225005789 NAD binding site [chemical binding]; other site
526225005790 tetramer interface [polypeptide binding]; other site
526225005791 catalytic site [active]
526225005792 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
526225005793 L-serine binding site [chemical binding]; other site
526225005794 ACT domain interface; other site
526225005795 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
526225005796 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
526225005797 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
526225005798 active site
526225005799 catalytic site [active]
526225005800 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
526225005801 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
526225005802 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
526225005803 active site
526225005804 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
526225005805 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526225005806 Coenzyme A binding pocket [chemical binding]; other site
526225005807 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
526225005808 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
526225005809 substrate binding pocket [chemical binding]; other site
526225005810 membrane-bound complex binding site; other site
526225005811 hinge residues; other site
526225005812 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
526225005813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526225005814 dimer interface [polypeptide binding]; other site
526225005815 conserved gate region; other site
526225005816 ABC-ATPase subunit interface; other site
526225005817 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
526225005818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526225005819 putative PBP binding loops; other site
526225005820 ABC-ATPase subunit interface; other site
526225005821 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
526225005822 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
526225005823 Walker A/P-loop; other site
526225005824 ATP binding site [chemical binding]; other site
526225005825 Q-loop/lid; other site
526225005826 ABC transporter signature motif; other site
526225005827 Walker B; other site
526225005828 D-loop; other site
526225005829 H-loop/switch region; other site
526225005830 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
526225005831 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526225005832 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
526225005833 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526225005834 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
526225005835 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
526225005836 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
526225005837 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225005838 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225005839 DNA binding residues [nucleotide binding]
526225005840 dimerization interface [polypeptide binding]; other site
526225005841 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
526225005842 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
526225005843 active site
526225005844 Zn binding site [ion binding]; other site
526225005845 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
526225005846 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
526225005847 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
526225005848 nucleophile elbow; other site
526225005849 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
526225005850 putative acyl-acceptor binding pocket; other site
526225005851 GYD domain; Region: GYD; pfam08734
526225005852 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
526225005853 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
526225005854 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
526225005855 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
526225005856 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
526225005857 Cytochrome P450; Region: p450; cl12078
526225005858 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
526225005859 active site
526225005860 catalytic residues [active]
526225005861 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
526225005862 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
526225005863 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
526225005864 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
526225005865 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
526225005866 alpha-dioxygenase; Region: PLN02283
526225005867 Animal heme oxidases similar to plant pathogen-inducible oxygenases; Region: PIOX_like; cd09818
526225005868 putative heme binding site [chemical binding]; other site
526225005869 putative active site [active]
526225005870 putative substrate binding site [chemical binding]; other site
526225005871 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
526225005872 active site
526225005873 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275
526225005874 active site
526225005875 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
526225005876 active site
526225005877 Zn binding site [ion binding]; other site
526225005878 Ferritin-like; Region: Ferritin-like; pfam12902
526225005879 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
526225005880 Domain of unknown function (DUF4071); Region: DUF4071; pfam13281
526225005881 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015
526225005882 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
526225005883 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
526225005884 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
526225005885 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827
526225005886 hypothetical protein; Validated; Region: PRK06201
526225005887 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
526225005888 enoyl-CoA hydratase; Provisional; Region: PRK06688
526225005889 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526225005890 substrate binding site [chemical binding]; other site
526225005891 oxyanion hole (OAH) forming residues; other site
526225005892 trimer interface [polypeptide binding]; other site
526225005893 TAP-like protein; Region: Abhydrolase_4; pfam08386
526225005894 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
526225005895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225005896 NAD(P) binding site [chemical binding]; other site
526225005897 active site
526225005898 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
526225005899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225005900 putative substrate translocation pore; other site
526225005901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225005902 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
526225005903 MerR HTH family regulatory protein; Region: MerR_1; pfam13411
526225005904 DNA binding residues [nucleotide binding]
526225005905 drug binding residues [chemical binding]; other site
526225005906 dimer interface [polypeptide binding]; other site
526225005907 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
526225005908 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
526225005909 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526225005910 nucleophilic elbow; other site
526225005911 catalytic triad; other site
526225005912 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
526225005913 Beta-lactamase; Region: Beta-lactamase; pfam00144
526225005914 Beta-lactamase; Region: Beta-lactamase; pfam00144
526225005915 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
526225005916 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
526225005917 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
526225005918 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
526225005919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225005920 ATP binding site [chemical binding]; other site
526225005921 Mg2+ binding site [ion binding]; other site
526225005922 G-X-G motif; other site
526225005923 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225005924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225005925 active site
526225005926 phosphorylation site [posttranslational modification]
526225005927 intermolecular recognition site; other site
526225005928 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225005929 DNA binding residues [nucleotide binding]
526225005930 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
526225005931 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
526225005932 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
526225005933 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526225005934 ATP binding site [chemical binding]; other site
526225005935 putative Mg++ binding site [ion binding]; other site
526225005936 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526225005937 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
526225005938 nucleotide binding region [chemical binding]; other site
526225005939 ATP-binding site [chemical binding]; other site
526225005940 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526225005941 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526225005942 active site
526225005943 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417
526225005944 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
526225005945 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225005946 ATP binding site [chemical binding]; other site
526225005947 Mg2+ binding site [ion binding]; other site
526225005948 G-X-G motif; other site
526225005949 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
526225005950 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526225005951 FeS/SAM binding site; other site
526225005952 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
526225005953 putative ligand binding pocket/active site [active]
526225005954 putative metal binding site [ion binding]; other site
526225005955 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
526225005956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225005957 putative substrate translocation pore; other site
526225005958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225005959 CsbD-like; Region: CsbD; pfam05532
526225005960 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
526225005961 FAD binding domain; Region: FAD_binding_4; pfam01565
526225005962 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
526225005963 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
526225005964 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
526225005965 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
526225005966 DNA binding site [nucleotide binding]
526225005967 Bacterial transcriptional activator domain; Region: BTAD; pfam03704
526225005968 Predicted ATPase [General function prediction only]; Region: COG3903
526225005969 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
526225005970 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
526225005971 CoenzymeA binding site [chemical binding]; other site
526225005972 subunit interaction site [polypeptide binding]; other site
526225005973 PHB binding site; other site
526225005974 coenzyme F420-dependent oxidoreductase, NP1902A family; Region: F420_NP1902A; TIGR04024
526225005975 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
526225005976 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225005977 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225005978 DNA binding residues [nucleotide binding]
526225005979 dimerization interface [polypeptide binding]; other site
526225005980 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
526225005981 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
526225005982 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
526225005983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225005984 NAD(P) binding site [chemical binding]; other site
526225005985 active site
526225005986 hypothetical protein; Provisional; Region: PRK08244
526225005987 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
526225005988 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
526225005989 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526225005990 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225005991 Transcriptional regulators [Transcription]; Region: MarR; COG1846
526225005992 Winged helix DNA-binding domain; Region: HTH_34; pfam13601
526225005993 Integrase core domain; Region: rve; pfam00665
526225005994 Integrase core domain; Region: rve_2; pfam13333
526225005995 Transposase; Region: HTH_Tnp_1; cl17663
526225005996 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
526225005997 Transposase; Region: DEDD_Tnp_IS110; pfam01548
526225005998 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
526225005999 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
526225006000 DDE superfamily endonuclease; Region: DDE_5; pfam13546
526225006001 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
526225006002 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
526225006003 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
526225006004 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
526225006005 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
526225006006 DDE superfamily endonuclease; Region: DDE_4; pfam13359
526225006007 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
526225006008 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
526225006009 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
526225006010 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
526225006011 Winged helix-turn helix; Region: HTH_29; pfam13551
526225006012 Homeodomain-like domain; Region: HTH_32; pfam13565
526225006013 Winged helix-turn helix; Region: HTH_33; pfam13592
526225006014 DDE superfamily endonuclease; Region: DDE_3; pfam13358
526225006015 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
526225006016 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
526225006017 Inorganic pyrophosphatase; Region: Pyrophosphatase; pfam00719
526225006018 dimer interface [polypeptide binding]; other site
526225006019 substrate binding site [chemical binding]; other site
526225006020 metal binding sites [ion binding]; metal-binding site
526225006021 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
526225006022 anti sigma factor interaction site; other site
526225006023 regulatory phosphorylation site [posttranslational modification]; other site
526225006024 Epoxide hydrolase N terminus; Region: EHN; pfam06441
526225006025 Dodecin; Region: Dodecin; pfam07311
526225006026 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889
526225006027 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
526225006028 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
526225006029 putative active site [active]
526225006030 putative metal binding site [ion binding]; other site
526225006031 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526225006032 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
526225006033 PGAP1-like protein; Region: PGAP1; pfam07819
526225006034 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
526225006035 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
526225006036 Transposase; Region: HTH_Tnp_1; cl17663
526225006037 Integrase core domain; Region: rve; pfam00665
526225006038 Integrase core domain; Region: rve_3; pfam13683
526225006039 Glycosyl hydrolase family 14; Region: Glyco_hydro_14; cl03185
526225006040 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
526225006041 active site
526225006042 catalytic residues [active]
526225006043 Transposase, Mutator family; Region: Transposase_mut; pfam00872
526225006044 MULE transposase domain; Region: MULE; pfam10551
526225006045 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
526225006046 active site
526225006047 Int/Topo IB signature motif; other site
526225006048 DNA binding site [nucleotide binding]
526225006049 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023
526225006050 active site
526225006051 catalytic residues [active]
526225006052 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526225006053 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
526225006054 TM-ABC transporter signature motif; other site
526225006055 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526225006056 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
526225006057 TM-ABC transporter signature motif; other site
526225006058 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
526225006059 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
526225006060 Walker A/P-loop; other site
526225006061 ATP binding site [chemical binding]; other site
526225006062 Q-loop/lid; other site
526225006063 ABC transporter signature motif; other site
526225006064 Walker B; other site
526225006065 D-loop; other site
526225006066 H-loop/switch region; other site
526225006067 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
526225006068 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
526225006069 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
526225006070 ligand binding site [chemical binding]; other site
526225006071 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
526225006072 Transcriptional regulators [Transcription]; Region: PurR; COG1609
526225006073 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
526225006074 DNA binding site [nucleotide binding]
526225006075 domain linker motif; other site
526225006076 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
526225006077 dimerization interface [polypeptide binding]; other site
526225006078 ligand binding site [chemical binding]; other site
526225006079 hypothetical protein; Provisional; Region: PRK07906
526225006080 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
526225006081 putative metal binding site [ion binding]; other site
526225006082 Transcriptional regulator [Transcription]; Region: LysR; COG0583
526225006083 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526225006084 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
526225006085 putative dimerization interface [polypeptide binding]; other site
526225006086 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
526225006087 aspartate racemase; Region: asp_race; TIGR00035
526225006088 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
526225006089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225006090 NAD(P) binding site [chemical binding]; other site
526225006091 active site
526225006092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225006093 S-adenosylmethionine binding site [chemical binding]; other site
526225006094 glycosyltransferase, MGT family; Region: MGT; TIGR01426
526225006095 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
526225006096 active site
526225006097 TDP-binding site; other site
526225006098 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526225006099 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225006100 TAP-like protein; Region: Abhydrolase_4; pfam08386
526225006101 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
526225006102 AAA domain; Region: AAA_30; pfam13604
526225006103 AAA domain; Region: AAA_22; pfam13401
526225006104 Family description; Region: UvrD_C_2; pfam13538
526225006105 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526225006106 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526225006107 active site
526225006108 catalytic tetrad [active]
526225006109 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
526225006110 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526225006111 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
526225006112 nucleophilic elbow; other site
526225006113 catalytic triad; other site
526225006114 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526225006115 MarR family; Region: MarR_2; cl17246
526225006116 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526225006117 catalytic core [active]
526225006118 Protein of unknown function (DUF3090); Region: DUF3090; cl12832
526225006119 conserved hypothetical protein; Region: TIGR03843
526225006120 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
526225006121 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
526225006122 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
526225006123 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
526225006124 active site
526225006125 HIGH motif; other site
526225006126 nucleotide binding site [chemical binding]; other site
526225006127 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
526225006128 active site
526225006129 KMSKS motif; other site
526225006130 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955
526225006131 putative tRNA binding surface [nucleotide binding]; other site
526225006132 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
526225006133 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
526225006134 Zn2+ binding site [ion binding]; other site
526225006135 Mg2+ binding site [ion binding]; other site
526225006136 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
526225006137 PAC2 family; Region: PAC2; pfam09754
526225006138 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
526225006139 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
526225006140 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740
526225006141 substrate binding pocket [chemical binding]; other site
526225006142 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
526225006143 B12 binding site [chemical binding]; other site
526225006144 cobalt ligand [ion binding]; other site
526225006145 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
526225006146 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
526225006147 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
526225006148 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
526225006149 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
526225006150 active site
526225006151 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
526225006152 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
526225006153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225006154 S-adenosylmethionine binding site [chemical binding]; other site
526225006155 proteasome ATPase; Region: pup_AAA; TIGR03689
526225006156 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526225006157 Walker A motif; other site
526225006158 ATP binding site [chemical binding]; other site
526225006159 Walker B motif; other site
526225006160 arginine finger; other site
526225006161 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688
526225006162 Pup-like protein; Region: Pup; cl05289
526225006163 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690
526225006164 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
526225006165 active site
526225006166 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691
526225006167 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
526225006168 active site
526225006169 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
526225006170 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982
526225006171 Predicted transcriptional regulator [Transcription]; Region: COG2378
526225006172 WYL domain; Region: WYL; pfam13280
526225006173 Predicted transcriptional regulator [Transcription]; Region: COG2378
526225006174 WYL domain; Region: WYL; pfam13280
526225006175 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
526225006176 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
526225006177 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
526225006178 DEAD-like helicases superfamily; Region: DEXDc; smart00487
526225006179 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526225006180 ATP binding site [chemical binding]; other site
526225006181 putative Mg++ binding site [ion binding]; other site
526225006182 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526225006183 ATP-binding site [chemical binding]; other site
526225006184 DSHCT (NUC185) domain; Region: DSHCT; pfam08148
526225006185 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
526225006186 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739
526225006187 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
526225006188 active site
526225006189 metal binding site 1 [ion binding]; metal-binding site
526225006190 putative 5' ssDNA interaction site; other site
526225006191 metal binding site 3; metal-binding site
526225006192 metal binding site 2 [ion binding]; metal-binding site
526225006193 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
526225006194 putative DNA binding site [nucleotide binding]; other site
526225006195 putative metal binding site [ion binding]; other site
526225006196 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
526225006197 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
526225006198 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
526225006199 active site
526225006200 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526225006201 putative DNA binding site [nucleotide binding]; other site
526225006202 putative Zn2+ binding site [ion binding]; other site
526225006203 AsnC family; Region: AsnC_trans_reg; pfam01037
526225006204 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
526225006205 protein-splicing catalytic site; other site
526225006206 thioester formation/cholesterol transfer; other site
526225006207 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
526225006208 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
526225006209 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
526225006210 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
526225006211 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
526225006212 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
526225006213 putative acyl-acceptor binding pocket; other site
526225006214 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
526225006215 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526225006216 Coenzyme A binding pocket [chemical binding]; other site
526225006217 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
526225006218 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
526225006219 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
526225006220 active site
526225006221 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
526225006222 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
526225006223 putative active site [active]
526225006224 catalytic triad [active]
526225006225 putative dimer interface [polypeptide binding]; other site
526225006226 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
526225006227 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
526225006228 Ligand binding site; other site
526225006229 Putative Catalytic site; other site
526225006230 DXD motif; other site
526225006231 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
526225006232 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
526225006233 thymidine kinase; Provisional; Region: PRK04296
526225006234 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
526225006235 ATP binding site [chemical binding]; other site
526225006236 Walker A motif; other site
526225006237 Walker B motif; other site
526225006238 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700
526225006239 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
526225006240 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
526225006241 putative active site [active]
526225006242 catalytic site [active]
526225006243 putative metal binding site [ion binding]; other site
526225006244 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
526225006245 putative active site [active]
526225006246 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526225006247 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
526225006248 active site
526225006249 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
526225006250 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
526225006251 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
526225006252 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
526225006253 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
526225006254 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
526225006255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526225006256 motif II; other site
526225006257 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
526225006258 substrate binding site [chemical binding]; other site
526225006259 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
526225006260 pantothenate kinase; Provisional; Region: PRK05439
526225006261 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
526225006262 ATP-binding site [chemical binding]; other site
526225006263 CoA-binding site [chemical binding]; other site
526225006264 Mg2+-binding site [ion binding]; other site
526225006265 glycine dehydrogenase; Provisional; Region: PRK05367
526225006266 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
526225006267 tetramer interface [polypeptide binding]; other site
526225006268 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225006269 catalytic residue [active]
526225006270 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
526225006271 tetramer interface [polypeptide binding]; other site
526225006272 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225006273 catalytic residue [active]
526225006274 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
526225006275 DNA binding residues [nucleotide binding]
526225006276 MerR HTH family regulatory protein; Region: MerR_1; pfam13411
526225006277 putative dimer interface [polypeptide binding]; other site
526225006278 Bifunctional nuclease; Region: DNase-RNase; pfam02577
526225006279 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
526225006280 MerR HTH family regulatory protein; Region: MerR_1; pfam13411
526225006281 DNA binding residues [nucleotide binding]
526225006282 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
526225006283 Double zinc ribbon; Region: DZR; pfam12773
526225006284 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
526225006285 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
526225006286 phosphopeptide binding site; other site
526225006287 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
526225006288 lipoyl attachment site [posttranslational modification]; other site
526225006289 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
526225006290 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
526225006291 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
526225006292 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
526225006293 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
526225006294 elongation factor G; Reviewed; Region: PRK12740
526225006295 G1 box; other site
526225006296 putative GEF interaction site [polypeptide binding]; other site
526225006297 GTP/Mg2+ binding site [chemical binding]; other site
526225006298 Switch I region; other site
526225006299 G2 box; other site
526225006300 G3 box; other site
526225006301 Switch II region; other site
526225006302 G4 box; other site
526225006303 G5 box; other site
526225006304 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
526225006305 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
526225006306 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
526225006307 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
526225006308 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
526225006309 Walker A/P-loop; other site
526225006310 ATP binding site [chemical binding]; other site
526225006311 ABC transporter; Region: ABC_tran; pfam00005
526225006312 Q-loop/lid; other site
526225006313 ABC transporter signature motif; other site
526225006314 Walker B; other site
526225006315 D-loop; other site
526225006316 H-loop/switch region; other site
526225006317 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
526225006318 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
526225006319 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225006320 Walker A/P-loop; other site
526225006321 ATP binding site [chemical binding]; other site
526225006322 Q-loop/lid; other site
526225006323 ABC transporter signature motif; other site
526225006324 Walker B; other site
526225006325 D-loop; other site
526225006326 H-loop/switch region; other site
526225006327 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
526225006328 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
526225006329 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
526225006330 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
526225006331 Transcriptional regulators [Transcription]; Region: PhnF; COG2188
526225006332 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526225006333 DNA-binding site [nucleotide binding]; DNA binding site
526225006334 UTRA domain; Region: UTRA; pfam07702
526225006335 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
526225006336 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
526225006337 substrate binding site [chemical binding]; other site
526225006338 ATP binding site [chemical binding]; other site
526225006339 KduI/IolB family; Region: KduI; pfam04962
526225006340 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
526225006341 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
526225006342 PYR/PP interface [polypeptide binding]; other site
526225006343 dimer interface [polypeptide binding]; other site
526225006344 TPP binding site [chemical binding]; other site
526225006345 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
526225006346 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
526225006347 TPP-binding site; other site
526225006348 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
526225006349 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526225006350 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526225006351 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
526225006352 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
526225006353 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
526225006354 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
526225006355 tetrameric interface [polypeptide binding]; other site
526225006356 NAD binding site [chemical binding]; other site
526225006357 catalytic residues [active]
526225006358 Transcriptional regulators [Transcription]; Region: PurR; COG1609
526225006359 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
526225006360 DNA binding site [nucleotide binding]
526225006361 domain linker motif; other site
526225006362 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
526225006363 dimerization interface [polypeptide binding]; other site
526225006364 ligand binding site [chemical binding]; other site
526225006365 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
526225006366 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
526225006367 DeoR C terminal sensor domain; Region: DeoRC; pfam00455
526225006368 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
526225006369 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
526225006370 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
526225006371 Sugar (and other) transporter; Region: Sugar_tr; pfam00083
526225006372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225006373 putative substrate translocation pore; other site
526225006374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225006375 Predicted membrane protein [Function unknown]; Region: COG4129
526225006376 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
526225006377 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
526225006378 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
526225006379 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526225006380 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526225006381 Transcriptional regulators [Transcription]; Region: PurR; COG1609
526225006382 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
526225006383 DNA binding site [nucleotide binding]
526225006384 domain linker motif; other site
526225006385 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
526225006386 ligand binding site [chemical binding]; other site
526225006387 dimerization interface [polypeptide binding]; other site
526225006388 Transcriptional regulators [Transcription]; Region: PurR; COG1609
526225006389 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
526225006390 Cytochrome P450; Region: p450; cl12078
526225006391 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
526225006392 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
526225006393 FMN-binding pocket [chemical binding]; other site
526225006394 flavin binding motif; other site
526225006395 phosphate binding motif [ion binding]; other site
526225006396 beta-alpha-beta structure motif; other site
526225006397 NAD binding pocket [chemical binding]; other site
526225006398 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526225006399 catalytic loop [active]
526225006400 iron binding site [ion binding]; other site
526225006401 Transcriptional regulators [Transcription]; Region: PurR; COG1609
526225006402 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
526225006403 DNA binding site [nucleotide binding]
526225006404 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
526225006405 ligand binding site [chemical binding]; other site
526225006406 dimerization interface [polypeptide binding]; other site
526225006407 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526225006408 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526225006409 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
526225006410 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
526225006411 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526225006412 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526225006413 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
526225006414 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526225006415 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526225006416 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
526225006417 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
526225006418 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
526225006419 DNA binding site [nucleotide binding]
526225006420 domain linker motif; other site
526225006421 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
526225006422 putative ligand binding site [chemical binding]; other site
526225006423 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526225006424 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526225006425 active site
526225006426 catalytic tetrad [active]
526225006427 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
526225006428 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
526225006429 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225006430 Walker A/P-loop; other site
526225006431 ATP binding site [chemical binding]; other site
526225006432 Q-loop/lid; other site
526225006433 ABC transporter signature motif; other site
526225006434 Walker B; other site
526225006435 D-loop; other site
526225006436 H-loop/switch region; other site
526225006437 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526225006438 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
526225006439 TM-ABC transporter signature motif; other site
526225006440 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
526225006441 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
526225006442 putative ligand binding site [chemical binding]; other site
526225006443 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526225006444 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526225006445 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
526225006446 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
526225006447 SnoaL-like domain; Region: SnoaL_2; pfam12680
526225006448 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830
526225006449 active site
526225006450 catalytic triad [active]
526225006451 oxyanion hole [active]
526225006452 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975
526225006453 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444
526225006454 active site
526225006455 DNA binding site [nucleotide binding]
526225006456 catalytic site [active]
526225006457 Cupin domain; Region: Cupin_2; pfam07883
526225006458 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
526225006459 putative active site [active]
526225006460 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
526225006461 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526225006462 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526225006463 active site
526225006464 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
526225006465 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
526225006466 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
526225006467 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
526225006468 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
526225006469 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
526225006470 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
526225006471 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
526225006472 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526225006473 motif II; other site
526225006474 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
526225006475 PAS domain; Region: PAS_9; pfam13426
526225006476 putative active site [active]
526225006477 heme pocket [chemical binding]; other site
526225006478 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199
526225006479 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
526225006480 metal binding site [ion binding]; metal-binding site
526225006481 active site
526225006482 I-site; other site
526225006483 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
526225006484 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
526225006485 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
526225006486 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
526225006487 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
526225006488 Walker A/P-loop; other site
526225006489 ATP binding site [chemical binding]; other site
526225006490 Q-loop/lid; other site
526225006491 ABC transporter signature motif; other site
526225006492 Walker B; other site
526225006493 D-loop; other site
526225006494 H-loop/switch region; other site
526225006495 TOBE domain; Region: TOBE_2; pfam08402
526225006496 L-idonate 5-dehydrogenase; Region: PLN02702
526225006497 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
526225006498 inhibitor binding site; inhibition site
526225006499 catalytic Zn binding site [ion binding]; other site
526225006500 structural Zn binding site [ion binding]; other site
526225006501 NADP binding site [chemical binding]; other site
526225006502 tetramer interface [polypeptide binding]; other site
526225006503 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
526225006504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526225006505 dimer interface [polypeptide binding]; other site
526225006506 conserved gate region; other site
526225006507 putative PBP binding loops; other site
526225006508 ABC-ATPase subunit interface; other site
526225006509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526225006510 dimer interface [polypeptide binding]; other site
526225006511 conserved gate region; other site
526225006512 putative PBP binding loops; other site
526225006513 ABC-ATPase subunit interface; other site
526225006514 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
526225006515 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
526225006516 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
526225006517 Helix-turn-helix domain; Region: HTH_28; pfam13518
526225006518 Putative sugar-binding domain; Region: Sugar-bind; pfam04198
526225006519 Phosphotransferase enzyme family; Region: APH; pfam01636
526225006520 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
526225006521 active site
526225006522 ATP binding site [chemical binding]; other site
526225006523 substrate binding site [chemical binding]; other site
526225006524 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830
526225006525 active site
526225006526 ADP/pyrophosphate binding site [chemical binding]; other site
526225006527 dimerization interface [polypeptide binding]; other site
526225006528 allosteric effector site; other site
526225006529 fructose-1,6-bisphosphate binding site; other site
526225006530 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
526225006531 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
526225006532 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
526225006533 TrkA-C domain; Region: TrkA_C; pfam02080
526225006534 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
526225006535 Ligand Binding Site [chemical binding]; other site
526225006536 MarR family; Region: MarR; pfam01047
526225006537 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
526225006538 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526225006539 non-specific DNA binding site [nucleotide binding]; other site
526225006540 salt bridge; other site
526225006541 sequence-specific DNA binding site [nucleotide binding]; other site
526225006542 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
526225006543 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
526225006544 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
526225006545 inhibitor-cofactor binding pocket; inhibition site
526225006546 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225006547 catalytic residue [active]
526225006548 Transcriptional regulators [Transcription]; Region: Lrp; COG1522
526225006549 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
526225006550 AsnC family; Region: AsnC_trans_reg; pfam01037
526225006551 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
526225006552 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
526225006553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526225006554 dimer interface [polypeptide binding]; other site
526225006555 conserved gate region; other site
526225006556 ABC-ATPase subunit interface; other site
526225006557 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
526225006558 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
526225006559 Walker A/P-loop; other site
526225006560 ATP binding site [chemical binding]; other site
526225006561 Q-loop/lid; other site
526225006562 ABC transporter signature motif; other site
526225006563 Walker B; other site
526225006564 D-loop; other site
526225006565 H-loop/switch region; other site
526225006566 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
526225006567 Sporulation and spore germination; Region: Germane; pfam10646
526225006568 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
526225006569 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
526225006570 dimerization interface [polypeptide binding]; other site
526225006571 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
526225006572 dimer interface [polypeptide binding]; other site
526225006573 phosphorylation site [posttranslational modification]
526225006574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225006575 ATP binding site [chemical binding]; other site
526225006576 Mg2+ binding site [ion binding]; other site
526225006577 G-X-G motif; other site
526225006578 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526225006579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225006580 active site
526225006581 phosphorylation site [posttranslational modification]
526225006582 intermolecular recognition site; other site
526225006583 dimerization interface [polypeptide binding]; other site
526225006584 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526225006585 DNA binding site [nucleotide binding]
526225006586 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
526225006587 anti sigma factor interaction site; other site
526225006588 regulatory phosphorylation site [posttranslational modification]; other site
526225006589 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
526225006590 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
526225006591 AAA domain; Region: AAA_30; pfam13604
526225006592 Family description; Region: UvrD_C_2; pfam13538
526225006593 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
526225006594 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
526225006595 dimer interface [polypeptide binding]; other site
526225006596 ssDNA binding site [nucleotide binding]; other site
526225006597 tetramer (dimer of dimers) interface [polypeptide binding]; other site
526225006598 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
526225006599 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526225006600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225006601 Transcriptional regulator [Transcription]; Region: IclR; COG1414
526225006602 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
526225006603 Bacterial transcriptional regulator; Region: IclR; pfam01614
526225006604 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
526225006605 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
526225006606 FMN-binding pocket [chemical binding]; other site
526225006607 flavin binding motif; other site
526225006608 phosphate binding motif [ion binding]; other site
526225006609 beta-alpha-beta structure motif; other site
526225006610 NAD binding pocket [chemical binding]; other site
526225006611 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526225006612 catalytic loop [active]
526225006613 iron binding site [ion binding]; other site
526225006614 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
526225006615 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
526225006616 iron-sulfur cluster [ion binding]; other site
526225006617 [2Fe-2S] cluster binding site [ion binding]; other site
526225006618 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
526225006619 alpha subunit interface [polypeptide binding]; other site
526225006620 active site
526225006621 substrate binding site [chemical binding]; other site
526225006622 Fe binding site [ion binding]; other site
526225006623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225006624 Major Facilitator Superfamily; Region: MFS_1; pfam07690
526225006625 putative substrate translocation pore; other site
526225006626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225006627 putative substrate translocation pore; other site
526225006628 succinic semialdehyde dehydrogenase; Region: PLN02278
526225006629 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
526225006630 tetramerization interface [polypeptide binding]; other site
526225006631 NAD(P) binding site [chemical binding]; other site
526225006632 catalytic residues [active]
526225006633 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
526225006634 aconitate hydratase; Validated; Region: PRK09277
526225006635 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
526225006636 substrate binding site [chemical binding]; other site
526225006637 ligand binding site [chemical binding]; other site
526225006638 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
526225006639 substrate binding site [chemical binding]; other site
526225006640 Transcriptional regulators [Transcription]; Region: GntR; COG1802
526225006641 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526225006642 DNA-binding site [nucleotide binding]; DNA binding site
526225006643 FCD domain; Region: FCD; pfam07729
526225006644 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
526225006645 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
526225006646 NodB motif; other site
526225006647 active site
526225006648 catalytic site [active]
526225006649 metal binding site [ion binding]; metal-binding site
526225006650 TIGR03084 family protein; Region: TIGR03084
526225006651 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
526225006652 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
526225006653 active site
526225006654 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
526225006655 urate oxidase; Region: urate_oxi; TIGR03383
526225006656 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263
526225006657 active site
526225006658 allantoicase; Provisional; Region: PRK13257
526225006659 Allantoicase repeat; Region: Allantoicase; pfam03561
526225006660 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315
526225006661 allantoinase; Region: allantoinase; TIGR03178
526225006662 active site
526225006663 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
526225006664 allophanate hydrolase; Provisional; Region: PRK08186
526225006665 Transcriptional regulators [Transcription]; Region: GntR; COG1802
526225006666 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526225006667 DNA-binding site [nucleotide binding]; DNA binding site
526225006668 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
526225006669 fructuronate transporter; Provisional; Region: PRK10034; cl15264
526225006670 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
526225006671 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
526225006672 metal binding site [ion binding]; metal-binding site
526225006673 Enolase C-terminal domain-like; Region: MR_MLE_C; pfam13378
526225006674 substrate binding pocket [chemical binding]; other site
526225006675 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
526225006676 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
526225006677 putative active site [active]
526225006678 putative FMN binding site [chemical binding]; other site
526225006679 putative substrate binding site [chemical binding]; other site
526225006680 putative catalytic residue [active]
526225006681 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526225006682 Winged helix-turn helix; Region: HTH_29; pfam13551
526225006683 Homeodomain-like domain; Region: HTH_32; pfam13565
526225006684 Transcriptional regulators [Transcription]; Region: GntR; COG1802
526225006685 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526225006686 DNA-binding site [nucleotide binding]; DNA binding site
526225006687 FCD domain; Region: FCD; pfam07729
526225006688 BCCT family transporter; Region: BCCT; pfam02028
526225006689 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
526225006690 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
526225006691 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
526225006692 [2Fe-2S] cluster binding site [ion binding]; other site
526225006693 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
526225006694 putative alpha subunit interface [polypeptide binding]; other site
526225006695 putative active site [active]
526225006696 putative substrate binding site [chemical binding]; other site
526225006697 Fe binding site [ion binding]; other site
526225006698 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
526225006699 Transcriptional regulator [Transcription]; Region: IclR; COG1414
526225006700 Bacterial transcriptional regulator; Region: IclR; pfam01614
526225006701 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
526225006702 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
526225006703 FAD binding pocket [chemical binding]; other site
526225006704 FAD binding motif [chemical binding]; other site
526225006705 phosphate binding motif [ion binding]; other site
526225006706 beta-alpha-beta structure motif; other site
526225006707 NAD binding pocket [chemical binding]; other site
526225006708 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526225006709 catalytic loop [active]
526225006710 iron binding site [ion binding]; other site
526225006711 Heavy-metal-associated domain; Region: HMA; pfam00403
526225006712 metal-binding site [ion binding]
526225006713 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
526225006714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225006715 NAD(P) binding site [chemical binding]; other site
526225006716 active site
526225006717 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
526225006718 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526225006719 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
526225006720 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
526225006721 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
526225006722 anti sigma factor interaction site; other site
526225006723 regulatory phosphorylation site [posttranslational modification]; other site
526225006724 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526225006725 PGAP1-like protein; Region: PGAP1; pfam07819
526225006726 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225006727 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225006728 DNA binding residues [nucleotide binding]
526225006729 dimerization interface [polypeptide binding]; other site
526225006730 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
526225006731 phosphoenolpyruvate synthase; Validated; Region: PRK06464
526225006732 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
526225006733 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
526225006734 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
526225006735 PEP synthetase regulatory protein; Provisional; Region: PRK05339
526225006736 aminodeoxychorismate synthase; Provisional; Region: PRK07508
526225006737 chorismate binding enzyme; Region: Chorismate_bind; cl10555
526225006738 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
526225006739 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
526225006740 substrate-cofactor binding pocket; other site
526225006741 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225006742 catalytic residue [active]
526225006743 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
526225006744 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
526225006745 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
526225006746 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
526225006747 putative active site [active]
526225006748 putative substrate binding site [chemical binding]; other site
526225006749 putative cosubstrate binding site; other site
526225006750 catalytic site [active]
526225006751 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
526225006752 Serine dehydratase beta chain; Region: SDH_beta; pfam03315
526225006753 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
526225006754 Transcriptional regulators [Transcription]; Region: GntR; COG1802
526225006755 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526225006756 DNA-binding site [nucleotide binding]; DNA binding site
526225006757 FCD domain; Region: FCD; pfam07729
526225006758 dihydropteroate synthase; Region: DHPS; TIGR01496
526225006759 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
526225006760 substrate binding pocket [chemical binding]; other site
526225006761 dimer interface [polypeptide binding]; other site
526225006762 inhibitor binding site; inhibition site
526225006763 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190
526225006764 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
526225006765 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
526225006766 homodimer interface [polypeptide binding]; other site
526225006767 NADP binding site [chemical binding]; other site
526225006768 substrate binding site [chemical binding]; other site
526225006769 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
526225006770 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
526225006771 hydroxyglutarate oxidase; Provisional; Region: PRK11728
526225006772 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
526225006773 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
526225006774 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
526225006775 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
526225006776 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
526225006777 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
526225006778 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
526225006779 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
526225006780 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
526225006781 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267
526225006782 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
526225006783 hydroxyglutarate oxidase; Provisional; Region: PRK11728
526225006784 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
526225006785 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
526225006786 dimer interface [polypeptide binding]; other site
526225006787 active site
526225006788 glycine-pyridoxal phosphate binding site [chemical binding]; other site
526225006789 folate binding site [chemical binding]; other site
526225006790 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
526225006791 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
526225006792 NAD binding site [chemical binding]; other site
526225006793 catalytic Zn binding site [ion binding]; other site
526225006794 substrate binding site [chemical binding]; other site
526225006795 structural Zn binding site [ion binding]; other site
526225006796 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
526225006797 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
526225006798 FAD binding site [chemical binding]; other site
526225006799 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
526225006800 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
526225006801 Transcriptional regulator [Transcription]; Region: IclR; COG1414
526225006802 Bacterial transcriptional regulator; Region: IclR; pfam01614
526225006803 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
526225006804 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
526225006805 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
526225006806 putative active site [active]
526225006807 putative substrate binding site [chemical binding]; other site
526225006808 putative cosubstrate binding site; other site
526225006809 catalytic site [active]
526225006810 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
526225006811 Serine dehydratase beta chain; Region: SDH_beta; pfam03315
526225006812 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
526225006813 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
526225006814 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
526225006815 [2Fe-2S] cluster binding site [ion binding]; other site
526225006816 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
526225006817 hydrophobic ligand binding site; other site
526225006818 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
526225006819 Transposase; Region: DDE_Tnp_ISL3; pfam01610
526225006820 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
526225006821 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
526225006822 FMN-binding pocket [chemical binding]; other site
526225006823 flavin binding motif; other site
526225006824 phosphate binding motif [ion binding]; other site
526225006825 beta-alpha-beta structure motif; other site
526225006826 NAD binding pocket [chemical binding]; other site
526225006827 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526225006828 catalytic loop [active]
526225006829 iron binding site [ion binding]; other site
526225006830 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
526225006831 dihydropteroate synthase; Region: DHPS; TIGR01496
526225006832 substrate binding pocket [chemical binding]; other site
526225006833 inhibitor binding site; inhibition site
526225006834 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
526225006835 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
526225006836 NAD binding site [chemical binding]; other site
526225006837 catalytic Zn binding site [ion binding]; other site
526225006838 substrate binding site [chemical binding]; other site
526225006839 structural Zn binding site [ion binding]; other site
526225006840 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
526225006841 Transposase, Mutator family; Region: Transposase_mut; pfam00872
526225006842 MULE transposase domain; Region: MULE; pfam10551
526225006843 BCCT family transporter; Region: BCCT; pfam02028
526225006844 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
526225006845 Transcriptional regulator [Transcription]; Region: IclR; COG1414
526225006846 Bacterial transcriptional regulator; Region: IclR; pfam01614
526225006847 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
526225006848 [2Fe-2S] cluster binding site [ion binding]; other site
526225006849 BCCT family transporter; Region: BCCT; pfam02028
526225006850 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
526225006851 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
526225006852 MOSC domain; Region: MOSC; pfam03473
526225006853 DDE superfamily endonuclease; Region: DDE_4; pfam13359
526225006854 Integral membrane protein TerC family; Region: TerC; cl10468
526225006855 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853
526225006856 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
526225006857 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
526225006858 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
526225006859 Walker A/P-loop; other site
526225006860 ATP binding site [chemical binding]; other site
526225006861 Q-loop/lid; other site
526225006862 ABC transporter signature motif; other site
526225006863 Walker B; other site
526225006864 D-loop; other site
526225006865 H-loop/switch region; other site
526225006866 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
526225006867 Major Facilitator Superfamily; Region: MFS_1; pfam07690
526225006868 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650
526225006869 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
526225006870 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
526225006871 Domain of unknown function (DUF4040); Region: DUF4040; cl00676
526225006872 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
526225006873 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
526225006874 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
526225006875 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899
526225006876 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
526225006877 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
526225006878 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
526225006879 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
526225006880 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
526225006881 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
526225006882 Transglycosylase associated protein; Region: Transgly_assoc; cl00978
526225006883 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
526225006884 Ligand Binding Site [chemical binding]; other site
526225006885 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
526225006886 anti sigma factor interaction site; other site
526225006887 regulatory phosphorylation site [posttranslational modification]; other site
526225006888 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
526225006889 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225006890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225006891 active site
526225006892 phosphorylation site [posttranslational modification]
526225006893 intermolecular recognition site; other site
526225006894 dimerization interface [polypeptide binding]; other site
526225006895 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225006896 DNA binding residues [nucleotide binding]
526225006897 dimerization interface [polypeptide binding]; other site
526225006898 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
526225006899 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
526225006900 Histidine kinase; Region: HisKA_3; pfam07730
526225006901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225006902 ATP binding site [chemical binding]; other site
526225006903 Mg2+ binding site [ion binding]; other site
526225006904 G-X-G motif; other site
526225006905 potassium/proton antiporter; Reviewed; Region: PRK05326
526225006906 TrkA-C domain; Region: TrkA_C; pfam02080
526225006907 hypothetical protein; Provisional; Region: PRK11573
526225006908 Domain of unknown function DUF21; Region: DUF21; pfam01595
526225006909 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
526225006910 Transporter associated domain; Region: CorC_HlyC; pfam03471
526225006911 Domain of unknown function DUF21; Region: DUF21; pfam01595
526225006912 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
526225006913 AAA ATPase domain; Region: AAA_16; pfam13191
526225006914 ATPases associated with a variety of cellular activities; Region: AAA; smart00382
526225006915 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225006916 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225006917 DNA binding residues [nucleotide binding]
526225006918 dimerization interface [polypeptide binding]; other site
526225006919 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
526225006920 HTH-like domain; Region: HTH_21; pfam13276
526225006921 Integrase core domain; Region: rve; pfam00665
526225006922 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
526225006923 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
526225006924 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
526225006925 transmembrane helices; other site
526225006926 malate dehydrogenase; Provisional; Region: PRK13529
526225006927 Malic enzyme, N-terminal domain; Region: malic; pfam00390
526225006928 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
526225006929 NAD(P) binding pocket [chemical binding]; other site
526225006930 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
526225006931 E3 interaction surface; other site
526225006932 lipoyl attachment site [posttranslational modification]; other site
526225006933 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
526225006934 E3 interaction surface; other site
526225006935 lipoyl attachment site [posttranslational modification]; other site
526225006936 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
526225006937 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526225006938 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526225006939 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
526225006940 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
526225006941 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
526225006942 E3 interaction surface; other site
526225006943 lipoyl attachment site [posttranslational modification]; other site
526225006944 e3 binding domain; Region: E3_binding; pfam02817
526225006945 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
526225006946 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
526225006947 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
526225006948 dimer interface [polypeptide binding]; other site
526225006949 TPP-binding site [chemical binding]; other site
526225006950 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
526225006951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225006952 active site
526225006953 phosphorylation site [posttranslational modification]
526225006954 intermolecular recognition site; other site
526225006955 dimerization interface [polypeptide binding]; other site
526225006956 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
526225006957 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
526225006958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225006959 putative substrate translocation pore; other site
526225006960 Lsr2; Region: Lsr2; pfam11774
526225006961 DDE superfamily endonuclease; Region: DDE_4; pfam13359
526225006962 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862
526225006963 putative hydrophobic ligand binding site [chemical binding]; other site
526225006964 Helix-turn-helix domain; Region: HTH_17; pfam12728
526225006965 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
526225006966 Int/Topo IB signature motif; other site
526225006967 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
526225006968 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
526225006969 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
526225006970 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526225006971 GTP-binding protein Der; Reviewed; Region: PRK03003
526225006972 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
526225006973 G1 box; other site
526225006974 GTP/Mg2+ binding site [chemical binding]; other site
526225006975 Switch I region; other site
526225006976 G2 box; other site
526225006977 Switch II region; other site
526225006978 G3 box; other site
526225006979 G4 box; other site
526225006980 G5 box; other site
526225006981 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
526225006982 G1 box; other site
526225006983 GTP/Mg2+ binding site [chemical binding]; other site
526225006984 Switch I region; other site
526225006985 G2 box; other site
526225006986 G3 box; other site
526225006987 Switch II region; other site
526225006988 G4 box; other site
526225006989 G5 box; other site
526225006990 cytidylate kinase; Provisional; Region: cmk; PRK00023
526225006991 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
526225006992 active site
526225006993 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
526225006994 CMP-binding site; other site
526225006995 The sites determining sugar specificity; other site
526225006996 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
526225006997 homotrimer interaction site [polypeptide binding]; other site
526225006998 active site
526225006999 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
526225007000 D-xylulose kinase; Region: XylB; TIGR01312
526225007001 nucleotide binding site [chemical binding]; other site
526225007002 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
526225007003 xylose isomerase; Provisional; Region: PRK12677
526225007004 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631
526225007005 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
526225007006 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
526225007007 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
526225007008 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
526225007009 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
526225007010 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
526225007011 RNA binding surface [nucleotide binding]; other site
526225007012 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
526225007013 active site
526225007014 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
526225007015 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354
526225007016 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
526225007017 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
526225007018 P-loop; other site
526225007019 Magnesium ion binding site [ion binding]; other site
526225007020 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
526225007021 Magnesium ion binding site [ion binding]; other site
526225007022 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
526225007023 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
526225007024 active site
526225007025 DNA binding site [nucleotide binding]
526225007026 Int/Topo IB signature motif; other site
526225007027 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
526225007028 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
526225007029 hexamer interface [polypeptide binding]; other site
526225007030 ligand binding site [chemical binding]; other site
526225007031 putative active site [active]
526225007032 NAD(P) binding site [chemical binding]; other site
526225007033 Domain of unknown function (DUF336); Region: DUF336; pfam03928
526225007034 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
526225007035 Peptidase family M28; Region: Peptidase_M28; pfam04389
526225007036 metal binding site [ion binding]; metal-binding site
526225007037 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
526225007038 dimer interface [polypeptide binding]; other site
526225007039 ADP-ribose binding site [chemical binding]; other site
526225007040 active site
526225007041 nudix motif; other site
526225007042 metal binding site [ion binding]; metal-binding site
526225007043 CTP synthetase; Validated; Region: pyrG; PRK05380
526225007044 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
526225007045 Catalytic site [active]
526225007046 active site
526225007047 UTP binding site [chemical binding]; other site
526225007048 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
526225007049 active site
526225007050 putative oxyanion hole; other site
526225007051 catalytic triad [active]
526225007052 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
526225007053 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
526225007054 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526225007055 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
526225007056 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
526225007057 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
526225007058 Thiamine pyrophosphokinase; Region: TPK; cl08415
526225007059 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
526225007060 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225007061 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
526225007062 Methyltransferase domain; Region: Methyltransf_26; pfam13659
526225007063 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
526225007064 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
526225007065 Walker A/P-loop; other site
526225007066 ATP binding site [chemical binding]; other site
526225007067 Q-loop/lid; other site
526225007068 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
526225007069 ABC transporter signature motif; other site
526225007070 Walker B; other site
526225007071 D-loop; other site
526225007072 H-loop/switch region; other site
526225007073 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
526225007074 ATP-NAD kinase; Region: NAD_kinase; pfam01513
526225007075 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
526225007076 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
526225007077 RNA binding surface [nucleotide binding]; other site
526225007078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225007079 S-adenosylmethionine binding site [chemical binding]; other site
526225007080 SCP-2 sterol transfer family; Region: SCP2; cl01225
526225007081 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
526225007082 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526225007083 active site
526225007084 motif I; other site
526225007085 motif II; other site
526225007086 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526225007087 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552
526225007088 Uncharacterized conserved protein [Function unknown]; Region: COG4198
526225007089 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
526225007090 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
526225007091 dimer interface [polypeptide binding]; other site
526225007092 ssDNA binding site [nucleotide binding]; other site
526225007093 tetramer (dimer of dimers) interface [polypeptide binding]; other site
526225007094 transcription termination factor Rho; Provisional; Region: PRK12678
526225007095 tyrosyl-tRNA synthetase; Validated; Region: PRK05912
526225007096 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
526225007097 active site
526225007098 HIGH motif; other site
526225007099 dimer interface [polypeptide binding]; other site
526225007100 KMSKS motif; other site
526225007101 S4 RNA-binding domain; Region: S4; smart00363
526225007102 RNA binding surface [nucleotide binding]; other site
526225007103 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
526225007104 active site
526225007105 DNA binding site [nucleotide binding]
526225007106 argininosuccinate lyase; Provisional; Region: PRK00855
526225007107 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
526225007108 active sites [active]
526225007109 tetramer interface [polypeptide binding]; other site
526225007110 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
526225007111 arginine repressor; Provisional; Region: PRK04280
526225007112 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
526225007113 ornithine carbamoyltransferase; Provisional; Region: PRK00779
526225007114 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
526225007115 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
526225007116 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
526225007117 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
526225007118 inhibitor-cofactor binding pocket; inhibition site
526225007119 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225007120 catalytic residue [active]
526225007121 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
526225007122 feedback inhibition sensing region; other site
526225007123 homohexameric interface [polypeptide binding]; other site
526225007124 nucleotide binding site [chemical binding]; other site
526225007125 N-acetyl-L-glutamate binding site [chemical binding]; other site
526225007126 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
526225007127 heterotetramer interface [polypeptide binding]; other site
526225007128 active site pocket [active]
526225007129 cleavage site
526225007130 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
526225007131 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
526225007132 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
526225007133 active site
526225007134 nucleophile elbow; other site
526225007135 Fusaric acid resistance protein family; Region: FUSC; pfam04632
526225007136 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
526225007137 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
526225007138 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
526225007139 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
526225007140 putative tRNA-binding site [nucleotide binding]; other site
526225007141 B3/4 domain; Region: B3_4; pfam03483
526225007142 tRNA synthetase B5 domain; Region: B5; smart00874
526225007143 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769
526225007144 dimer interface [polypeptide binding]; other site
526225007145 motif 1; other site
526225007146 motif 3; other site
526225007147 motif 2; other site
526225007148 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
526225007149 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
526225007150 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
526225007151 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
526225007152 dimer interface [polypeptide binding]; other site
526225007153 motif 1; other site
526225007154 active site
526225007155 motif 2; other site
526225007156 motif 3; other site
526225007157 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
526225007158 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
526225007159 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
526225007160 Ribosomal protein L20; Region: Ribosomal_L20; cd07026
526225007161 23S rRNA binding site [nucleotide binding]; other site
526225007162 L21 binding site [polypeptide binding]; other site
526225007163 L13 binding site [polypeptide binding]; other site
526225007164 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
526225007165 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
526225007166 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
526225007167 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
526225007168 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
526225007169 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
526225007170 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
526225007171 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
526225007172 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239
526225007173 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
526225007174 active site
526225007175 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526225007176 DNA binding site [nucleotide binding]
526225007177 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
526225007178 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
526225007179 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526225007180 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526225007181 DNA binding residues [nucleotide binding]
526225007182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225007183 S-adenosylmethionine binding site [chemical binding]; other site
526225007184 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526225007185 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526225007186 sequence-specific DNA binding site [nucleotide binding]; other site
526225007187 salt bridge; other site
526225007188 Cupin domain; Region: Cupin_2; pfam07883
526225007189 O-methyltransferase; Region: Methyltransf_2; pfam00891
526225007190 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
526225007191 iron-sulfur cluster [ion binding]; other site
526225007192 [2Fe-2S] cluster binding site [ion binding]; other site
526225007193 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
526225007194 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526225007195 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
526225007196 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
526225007197 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
526225007198 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
526225007199 [4Fe-4S] binding site [ion binding]; other site
526225007200 molybdopterin cofactor binding site; other site
526225007201 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
526225007202 molybdopterin cofactor binding site; other site
526225007203 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526225007204 Acetyltransferases [General function prediction only]; Region: RimI; COG0456
526225007205 Coenzyme A binding pocket [chemical binding]; other site
526225007206 YCII-related domain; Region: YCII; cl00999
526225007207 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
526225007208 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526225007209 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526225007210 DNA binding residues [nucleotide binding]
526225007211 hypothetical protein; Provisional; Region: PRK09256
526225007212 Haemolytic domain; Region: Haemolytic; pfam01809
526225007213 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
526225007214 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
526225007215 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
526225007216 putative trimer interface [polypeptide binding]; other site
526225007217 putative CoA binding site [chemical binding]; other site
526225007218 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
526225007219 putative trimer interface [polypeptide binding]; other site
526225007220 putative CoA binding site [chemical binding]; other site
526225007221 short chain dehydrogenase; Provisional; Region: PRK06701
526225007222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225007223 NAD(P) binding site [chemical binding]; other site
526225007224 active site
526225007225 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
526225007226 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526225007227 ATP binding site [chemical binding]; other site
526225007228 putative Mg++ binding site [ion binding]; other site
526225007229 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526225007230 nucleotide binding region [chemical binding]; other site
526225007231 ATP-binding site [chemical binding]; other site
526225007232 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
526225007233 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
526225007234 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
526225007235 dimer interface [polypeptide binding]; other site
526225007236 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225007237 catalytic residue [active]
526225007238 Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526225007239 Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526225007240 Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526225007241 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
526225007242 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
526225007243 putative trimer interface [polypeptide binding]; other site
526225007244 putative CoA binding site [chemical binding]; other site
526225007245 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
526225007246 putative CoA binding site [chemical binding]; other site
526225007247 putative trimer interface [polypeptide binding]; other site
526225007248 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526225007249 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
526225007250 acyl-activating enzyme (AAE) consensus motif; other site
526225007251 AMP binding site [chemical binding]; other site
526225007252 Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526225007253 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
526225007254 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944
526225007255 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
526225007256 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
526225007257 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526225007258 catalytic residue [active]
526225007259 Protein of unknown function (DUF418); Region: DUF418; cl12135
526225007260 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
526225007261 trehalose synthase; Region: treS_nterm; TIGR02456
526225007262 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
526225007263 active site
526225007264 catalytic site [active]
526225007265 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885
526225007266 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
526225007267 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199
526225007268 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
526225007269 metal binding site [ion binding]; metal-binding site
526225007270 active site
526225007271 I-site; other site
526225007272 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
526225007273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
526225007274 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
526225007275 Coenzyme A transferase; Region: CoA_trans; cl17247
526225007276 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
526225007277 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
526225007278 PYR/PP interface [polypeptide binding]; other site
526225007279 dimer interface [polypeptide binding]; other site
526225007280 TPP binding site [chemical binding]; other site
526225007281 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
526225007282 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
526225007283 TPP-binding site [chemical binding]; other site
526225007284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
526225007285 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
526225007286 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
526225007287 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526225007288 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
526225007289 dimerization interface [polypeptide binding]; other site
526225007290 substrate binding pocket [chemical binding]; other site
526225007291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
526225007292 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
526225007293 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
526225007294 hypothetical protein; Provisional; Region: PRK07877
526225007295 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
526225007296 Ligand Binding Site [chemical binding]; other site
526225007297 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225007298 NADH(P)-binding; Region: NAD_binding_10; pfam13460
526225007299 NAD(P) binding site [chemical binding]; other site
526225007300 active site
526225007301 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526225007302 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526225007303 non-specific DNA binding site [nucleotide binding]; other site
526225007304 salt bridge; other site
526225007305 sequence-specific DNA binding site [nucleotide binding]; other site
526225007306 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
526225007307 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
526225007308 putative active site [active]
526225007309 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
526225007310 clavulanic acid dehydrogenase (CAD), classical (c) SDR; Region: CAD_SDR_c; cd08934
526225007311 NADP binding site [chemical binding]; other site
526225007312 homotetramer interface [polypeptide binding]; other site
526225007313 homodimer interface [polypeptide binding]; other site
526225007314 active site
526225007315 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
526225007316 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
526225007317 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
526225007318 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
526225007319 ATP phosphoribosyltransferase; Region: hisG; TIGR00070
526225007320 HisG, C-terminal domain; Region: HisG_C; pfam08029
526225007321 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
526225007322 homodimer interface [polypeptide binding]; other site
526225007323 putative metal binding site [ion binding]; other site
526225007324 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
526225007325 homopentamer interface [polypeptide binding]; other site
526225007326 active site
526225007327 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
526225007328 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
526225007329 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
526225007330 dimerization interface [polypeptide binding]; other site
526225007331 active site
526225007332 riboflavin synthase subunit alpha; Provisional; Region: PRK09289
526225007333 Lumazine binding domain; Region: Lum_binding; pfam00677
526225007334 Lumazine binding domain; Region: Lum_binding; pfam00677
526225007335 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
526225007336 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
526225007337 catalytic motif [active]
526225007338 Zn binding site [ion binding]; other site
526225007339 RibD C-terminal domain; Region: RibD_C; cl17279
526225007340 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
526225007341 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
526225007342 substrate binding site [chemical binding]; other site
526225007343 hexamer interface [polypeptide binding]; other site
526225007344 metal binding site [ion binding]; metal-binding site
526225007345 Histidine kinase; Region: HisKA_3; pfam07730
526225007346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225007347 ATP binding site [chemical binding]; other site
526225007348 Mg2+ binding site [ion binding]; other site
526225007349 G-X-G motif; other site
526225007350 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225007351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225007352 active site
526225007353 phosphorylation site [posttranslational modification]
526225007354 intermolecular recognition site; other site
526225007355 dimerization interface [polypeptide binding]; other site
526225007356 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225007357 DNA binding residues [nucleotide binding]
526225007358 dimerization interface [polypeptide binding]; other site
526225007359 16S rRNA methyltransferase B; Provisional; Region: PRK14902
526225007360 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
526225007361 putative RNA binding site [nucleotide binding]; other site
526225007362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225007363 S-adenosylmethionine binding site [chemical binding]; other site
526225007364 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
526225007365 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
526225007366 putative active site [active]
526225007367 substrate binding site [chemical binding]; other site
526225007368 putative cosubstrate binding site; other site
526225007369 catalytic site [active]
526225007370 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
526225007371 substrate binding site [chemical binding]; other site
526225007372 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
526225007373 active site
526225007374 catalytic residues [active]
526225007375 metal binding site [ion binding]; metal-binding site
526225007376 primosome assembly protein PriA; Provisional; Region: PRK14873
526225007377 S-adenosylmethionine synthetase; Validated; Region: PRK05250
526225007378 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
526225007379 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
526225007380 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
526225007381 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
526225007382 Flavoprotein; Region: Flavoprotein; pfam02441
526225007383 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
526225007384 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
526225007385 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
526225007386 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
526225007387 catalytic site [active]
526225007388 G-X2-G-X-G-K; other site
526225007389 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
526225007390 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
526225007391 active site
526225007392 dimer interface [polypeptide binding]; other site
526225007393 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
526225007394 phosphate binding site [ion binding]; other site
526225007395 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
526225007396 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
526225007397 ATP-grasp domain; Region: ATP-grasp_4; cl17255
526225007398 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
526225007399 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
526225007400 ATP-grasp domain; Region: ATP-grasp_4; cl17255
526225007401 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
526225007402 IMP binding site; other site
526225007403 dimer interface [polypeptide binding]; other site
526225007404 interdomain contacts; other site
526225007405 partial ornithine binding site; other site
526225007406 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
526225007407 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
526225007408 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
526225007409 catalytic site [active]
526225007410 subunit interface [polypeptide binding]; other site
526225007411 dihydroorotase; Validated; Region: pyrC; PRK09357
526225007412 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
526225007413 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
526225007414 active site
526225007415 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
526225007416 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670
526225007417 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
526225007418 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
526225007419 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205
526225007420 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526225007421 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526225007422 non-specific DNA binding site [nucleotide binding]; other site
526225007423 salt bridge; other site
526225007424 sequence-specific DNA binding site [nucleotide binding]; other site
526225007425 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225007426 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225007427 DNA binding residues [nucleotide binding]
526225007428 dimerization interface [polypeptide binding]; other site
526225007429 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
526225007430 transcription antitermination factor NusB; Region: nusB; TIGR01951
526225007431 putative RNA binding site [nucleotide binding]; other site
526225007432 elongation factor P; Validated; Region: PRK00529
526225007433 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
526225007434 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
526225007435 RNA binding site [nucleotide binding]; other site
526225007436 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
526225007437 RNA binding site [nucleotide binding]; other site
526225007438 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
526225007439 aminopeptidase; Provisional; Region: PRK09795
526225007440 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
526225007441 active site
526225007442 Dehydroquinase class II; Region: DHquinase_II; pfam01220
526225007443 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
526225007444 trimer interface [polypeptide binding]; other site
526225007445 active site
526225007446 dimer interface [polypeptide binding]; other site
526225007447 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
526225007448 active site
526225007449 dimer interface [polypeptide binding]; other site
526225007450 metal binding site [ion binding]; metal-binding site
526225007451 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
526225007452 Shikimate kinase; Region: SKI; pfam01202
526225007453 ADP binding site [chemical binding]; other site
526225007454 magnesium binding site [ion binding]; other site
526225007455 putative shikimate binding site; other site
526225007456 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
526225007457 chorismate synthase; Validated; Region: PRK05382
526225007458 Tetramer interface [polypeptide binding]; other site
526225007459 active site
526225007460 FMN-binding site [chemical binding]; other site
526225007461 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
526225007462 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
526225007463 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
526225007464 shikimate binding site; other site
526225007465 NAD(P) binding site [chemical binding]; other site
526225007466 YceG-like family; Region: YceG; pfam02618
526225007467 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
526225007468 dimerization interface [polypeptide binding]; other site
526225007469 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
526225007470 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
526225007471 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
526225007472 motif 1; other site
526225007473 active site
526225007474 motif 2; other site
526225007475 motif 3; other site
526225007476 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
526225007477 recombination factor protein RarA; Reviewed; Region: PRK13342
526225007478 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526225007479 Walker A motif; other site
526225007480 ATP binding site [chemical binding]; other site
526225007481 Walker B motif; other site
526225007482 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
526225007483 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526225007484 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526225007485 active site
526225007486 catalytic tetrad [active]
526225007487 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
526225007488 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
526225007489 dimer interface [polypeptide binding]; other site
526225007490 anticodon binding site; other site
526225007491 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
526225007492 homodimer interface [polypeptide binding]; other site
526225007493 motif 1; other site
526225007494 active site
526225007495 motif 2; other site
526225007496 GAD domain; Region: GAD; pfam02938
526225007497 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
526225007498 active site
526225007499 motif 3; other site
526225007500 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526225007501 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526225007502 active site
526225007503 catalytic tetrad [active]
526225007504 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
526225007505 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
526225007506 dimer interface [polypeptide binding]; other site
526225007507 motif 1; other site
526225007508 active site
526225007509 motif 2; other site
526225007510 motif 3; other site
526225007511 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
526225007512 anticodon binding site; other site
526225007513 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
526225007514 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
526225007515 active site
526225007516 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
526225007517 active site
526225007518 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
526225007519 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
526225007520 Zn2+ binding site [ion binding]; other site
526225007521 Mg2+ binding site [ion binding]; other site
526225007522 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
526225007523 synthetase active site [active]
526225007524 NTP binding site [chemical binding]; other site
526225007525 metal binding site [ion binding]; metal-binding site
526225007526 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
526225007527 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
526225007528 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
526225007529 active site
526225007530 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
526225007531 Protein export membrane protein; Region: SecD_SecF; cl14618
526225007532 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
526225007533 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
526225007534 Preprotein translocase subunit; Region: YajC; pfam02699
526225007535 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
526225007536 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526225007537 Walker A motif; other site
526225007538 ATP binding site [chemical binding]; other site
526225007539 Walker B motif; other site
526225007540 arginine finger; other site
526225007541 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
526225007542 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
526225007543 RuvA N terminal domain; Region: RuvA_N; pfam01330
526225007544 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
526225007545 active site
526225007546 putative DNA-binding cleft [nucleotide binding]; other site
526225007547 dimer interface [polypeptide binding]; other site
526225007548 hypothetical protein; Validated; Region: PRK00110
526225007549 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
526225007550 predicted active site [active]
526225007551 catalytic triad [active]
526225007552 Protein of unknown function (DUF1624); Region: DUF1624; cl01394
526225007553 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
526225007554 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
526225007555 active site
526225007556 multimer interface [polypeptide binding]; other site
526225007557 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526225007558 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
526225007559 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
526225007560 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
526225007561 putative acyl-acceptor binding pocket; other site
526225007562 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
526225007563 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
526225007564 nucleotide binding site/active site [active]
526225007565 HIT family signature motif; other site
526225007566 catalytic residue [active]
526225007567 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
526225007568 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
526225007569 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
526225007570 active site
526225007571 dimer interface [polypeptide binding]; other site
526225007572 motif 1; other site
526225007573 motif 2; other site
526225007574 motif 3; other site
526225007575 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
526225007576 anticodon binding site; other site
526225007577 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
526225007578 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
526225007579 MOSC domain; Region: MOSC; pfam03473
526225007580 HNH endonuclease; Region: HNH; pfam01844
526225007581 RibD C-terminal domain; Region: RibD_C; cl17279
526225007582 Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656
526225007583 Putative zinc-finger; Region: zf-HC2; pfam13490
526225007584 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
526225007585 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526225007586 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526225007587 DNA binding residues [nucleotide binding]
526225007588 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686
526225007589 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
526225007590 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
526225007591 CoA-binding site [chemical binding]; other site
526225007592 ATP-binding [chemical binding]; other site
526225007593 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
526225007594 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
526225007595 RNA binding site [nucleotide binding]; other site
526225007596 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
526225007597 RNA binding site [nucleotide binding]; other site
526225007598 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
526225007599 RNA binding site [nucleotide binding]; other site
526225007600 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
526225007601 RNA binding site [nucleotide binding]; other site
526225007602 domain interface; other site
526225007603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225007604 S-adenosylmethionine binding site [chemical binding]; other site
526225007605 DNA polymerase I; Provisional; Region: PRK05755
526225007606 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
526225007607 active site
526225007608 putative 5' ssDNA interaction site; other site
526225007609 metal binding site 3; metal-binding site
526225007610 metal binding site 1 [ion binding]; metal-binding site
526225007611 metal binding site 2 [ion binding]; metal-binding site
526225007612 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
526225007613 putative DNA binding site [nucleotide binding]; other site
526225007614 putative metal binding site [ion binding]; other site
526225007615 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
526225007616 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
526225007617 active site
526225007618 DNA binding site [nucleotide binding]
526225007619 catalytic site [active]
526225007620 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
526225007621 CoenzymeA binding site [chemical binding]; other site
526225007622 subunit interaction site [polypeptide binding]; other site
526225007623 PHB binding site; other site
526225007624 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
526225007625 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526225007626 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
526225007627 TM-ABC transporter signature motif; other site
526225007628 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526225007629 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
526225007630 TM-ABC transporter signature motif; other site
526225007631 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
526225007632 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
526225007633 Walker A/P-loop; other site
526225007634 ATP binding site [chemical binding]; other site
526225007635 Q-loop/lid; other site
526225007636 ABC transporter signature motif; other site
526225007637 Walker B; other site
526225007638 D-loop; other site
526225007639 H-loop/switch region; other site
526225007640 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
526225007641 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
526225007642 Walker A/P-loop; other site
526225007643 ATP binding site [chemical binding]; other site
526225007644 Q-loop/lid; other site
526225007645 ABC transporter signature motif; other site
526225007646 Walker B; other site
526225007647 D-loop; other site
526225007648 H-loop/switch region; other site
526225007649 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
526225007650 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
526225007651 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
526225007652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225007653 active site
526225007654 phosphorylation site [posttranslational modification]
526225007655 intermolecular recognition site; other site
526225007656 dimerization interface [polypeptide binding]; other site
526225007657 ANTAR domain; Region: ANTAR; pfam03861
526225007658 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
526225007659 tyrosine decarboxylase; Region: PLN02880
526225007660 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526225007661 catalytic residue [active]
526225007662 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
526225007663 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
526225007664 active site
526225007665 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
526225007666 catalytic triad [active]
526225007667 dimer interface [polypeptide binding]; other site
526225007668 pyruvate kinase; Provisional; Region: PRK06247
526225007669 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
526225007670 domain interfaces; other site
526225007671 active site
526225007672 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
526225007673 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526225007674 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
526225007675 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
526225007676 active site
526225007677 dimer interface [polypeptide binding]; other site
526225007678 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
526225007679 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
526225007680 active site
526225007681 FMN binding site [chemical binding]; other site
526225007682 substrate binding site [chemical binding]; other site
526225007683 3Fe-4S cluster binding site [ion binding]; other site
526225007684 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
526225007685 domain interface; other site
526225007686 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
526225007687 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
526225007688 substrate binding site [chemical binding]; other site
526225007689 active site
526225007690 catalytic residues [active]
526225007691 heterodimer interface [polypeptide binding]; other site
526225007692 tryptophan synthase, beta subunit; Region: trpB; TIGR00263
526225007693 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
526225007694 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225007695 catalytic residue [active]
526225007696 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
526225007697 active site
526225007698 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
526225007699 active site
526225007700 ribulose/triose binding site [chemical binding]; other site
526225007701 phosphate binding site [ion binding]; other site
526225007702 substrate (anthranilate) binding pocket [chemical binding]; other site
526225007703 product (indole) binding pocket [chemical binding]; other site
526225007704 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850
526225007705 anthranilate synthase component I; Provisional; Region: PRK13571
526225007706 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
526225007707 chorismate binding enzyme; Region: Chorismate_bind; pfam00425
526225007708 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
526225007709 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
526225007710 FAD binding domain; Region: FAD_binding_2; pfam00890
526225007711 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
526225007712 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
526225007713 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225007714 Walker A/P-loop; other site
526225007715 ATP binding site [chemical binding]; other site
526225007716 Q-loop/lid; other site
526225007717 ABC transporter signature motif; other site
526225007718 Walker B; other site
526225007719 D-loop; other site
526225007720 H-loop/switch region; other site
526225007721 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
526225007722 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
526225007723 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225007724 Walker A/P-loop; other site
526225007725 ATP binding site [chemical binding]; other site
526225007726 Q-loop/lid; other site
526225007727 ABC transporter signature motif; other site
526225007728 Walker B; other site
526225007729 D-loop; other site
526225007730 H-loop/switch region; other site
526225007731 TIGR03085 family protein; Region: TIGR03085
526225007732 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
526225007733 Histidine biosynthesis protein; Region: His_biosynth; pfam00977
526225007734 substrate binding site [chemical binding]; other site
526225007735 glutamase interaction surface [polypeptide binding]; other site
526225007736 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
526225007737 homotrimer interaction site [polypeptide binding]; other site
526225007738 putative active site [active]
526225007739 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
526225007740 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
526225007741 catalytic residues [active]
526225007742 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
526225007743 FMN binding site [chemical binding]; other site
526225007744 dimer interface [polypeptide binding]; other site
526225007745 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
526225007746 classical (c) SDRs; Region: SDR_c; cd05233
526225007747 NAD(P) binding site [chemical binding]; other site
526225007748 active site
526225007749 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
526225007750 metal coordination site [ion binding]; other site
526225007751 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
526225007752 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
526225007753 putative active site [active]
526225007754 oxyanion strand; other site
526225007755 catalytic triad [active]
526225007756 Domain of unknown function (DUF222); Region: DUF222; pfam02720
526225007757 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
526225007758 putative active site pocket [active]
526225007759 4-fold oligomerization interface [polypeptide binding]; other site
526225007760 metal binding residues [ion binding]; metal-binding site
526225007761 3-fold/trimer interface [polypeptide binding]; other site
526225007762 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
526225007763 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
526225007764 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225007765 homodimer interface [polypeptide binding]; other site
526225007766 catalytic residue [active]
526225007767 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
526225007768 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
526225007769 NAD binding site [chemical binding]; other site
526225007770 dimerization interface [polypeptide binding]; other site
526225007771 product binding site; other site
526225007772 substrate binding site [chemical binding]; other site
526225007773 zinc binding site [ion binding]; other site
526225007774 catalytic residues [active]
526225007775 ATP-dependent protease La (LON) domain; Region: LON; pfam02190
526225007776 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
526225007777 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
526225007778 active site
526225007779 PHP Thumb interface [polypeptide binding]; other site
526225007780 metal binding site [ion binding]; metal-binding site
526225007781 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
526225007782 generic binding surface II; other site
526225007783 generic binding surface I; other site
526225007784 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
526225007785 CAAX protease self-immunity; Region: Abi; pfam02517
526225007786 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
526225007787 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
526225007788 active site
526225007789 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
526225007790 malate:quinone oxidoreductase; Validated; Region: PRK05257
526225007791 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
526225007792 potassium/proton antiporter; Reviewed; Region: PRK05326
526225007793 TrkA-C domain; Region: TrkA_C; pfam02080
526225007794 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
526225007795 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
526225007796 active site
526225007797 HIGH motif; other site
526225007798 nucleotide binding site [chemical binding]; other site
526225007799 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
526225007800 active site
526225007801 KMSKS motif; other site
526225007802 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
526225007803 tRNA binding surface [nucleotide binding]; other site
526225007804 anticodon binding site; other site
526225007805 DivIVA protein; Region: DivIVA; pfam05103
526225007806 DivIVA domain; Region: DivI1A_domain; TIGR03544
526225007807 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525
526225007808 YGGT family; Region: YGGT; pfam02325
526225007809 Protein of unknown function (DUF552); Region: DUF552; cl00775
526225007810 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
526225007811 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
526225007812 catalytic residue [active]
526225007813 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
526225007814 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
526225007815 cell division protein FtsZ; Validated; Region: PRK09330
526225007816 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
526225007817 nucleotide binding site [chemical binding]; other site
526225007818 SulA interaction site; other site
526225007819 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
526225007820 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
526225007821 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
526225007822 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
526225007823 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
526225007824 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
526225007825 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
526225007826 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
526225007827 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
526225007828 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
526225007829 active site
526225007830 homodimer interface [polypeptide binding]; other site
526225007831 cell division protein FtsW; Region: ftsW; TIGR02614
526225007832 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
526225007833 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
526225007834 Mg++ binding site [ion binding]; other site
526225007835 putative catalytic motif [active]
526225007836 putative substrate binding site [chemical binding]; other site
526225007837 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
526225007838 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
526225007839 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
526225007840 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
526225007841 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
526225007842 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
526225007843 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
526225007844 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
526225007845 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
526225007846 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
526225007847 MraW methylase family; Region: Methyltransf_5; cl17771
526225007848 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
526225007849 cell division protein MraZ; Reviewed; Region: PRK00326
526225007850 MraZ protein; Region: MraZ; pfam02381
526225007851 MraZ protein; Region: MraZ; pfam02381
526225007852 MoxR-like ATPases [General function prediction only]; Region: COG0714
526225007853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526225007854 ATP binding site [chemical binding]; other site
526225007855 Walker A motif; other site
526225007856 Walker B motif; other site
526225007857 arginine finger; other site
526225007858 Protein of unknown function DUF58; Region: DUF58; pfam01882
526225007859 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
526225007860 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
526225007861 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
526225007862 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
526225007863 active site
526225007864 DNA polymerase IV; Validated; Region: PRK02406
526225007865 DNA binding site [nucleotide binding]
526225007866 Cupin-like domain; Region: Cupin_8; pfam13621
526225007867 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
526225007868 putative dimer interface [polypeptide binding]; other site
526225007869 putative [2Fe-2S] cluster binding site [ion binding]; other site
526225007870 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
526225007871 Beta-lactamase; Region: Beta-lactamase; pfam00144
526225007872 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
526225007873 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415
526225007874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225007875 S-adenosylmethionine binding site [chemical binding]; other site
526225007876 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
526225007877 dimer interface [polypeptide binding]; other site
526225007878 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
526225007879 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
526225007880 active site
526225007881 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
526225007882 generic binding surface II; other site
526225007883 generic binding surface I; other site
526225007884 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
526225007885 putative deacylase active site [active]
526225007886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526225007887 Acetyltransferases [General function prediction only]; Region: RimI; COG0456
526225007888 Coenzyme A binding pocket [chemical binding]; other site
526225007889 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
526225007890 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
526225007891 Protein of unknown function (DUF422); Region: DUF422; cl00991
526225007892 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526225007893 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
526225007894 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
526225007895 substrate binding site [chemical binding]; other site
526225007896 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
526225007897 ATP binding site [chemical binding]; other site
526225007898 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
526225007899 Lipase (class 2); Region: Lipase_2; pfam01674
526225007900 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526225007901 dimerization interface [polypeptide binding]; other site
526225007902 putative DNA binding site [nucleotide binding]; other site
526225007903 Transcriptional regulators [Transcription]; Region: MarR; COG1846
526225007904 putative Zn2+ binding site [ion binding]; other site
526225007905 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
526225007906 putative hydrophobic ligand binding site [chemical binding]; other site
526225007907 TIGR03086 family protein; Region: TIGR03086
526225007908 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
526225007909 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225007910 Walker A/P-loop; other site
526225007911 ATP binding site [chemical binding]; other site
526225007912 Q-loop/lid; other site
526225007913 ABC transporter signature motif; other site
526225007914 Walker B; other site
526225007915 D-loop; other site
526225007916 H-loop/switch region; other site
526225007917 Protein of unknown function (DUF3714); Region: DUF3714; pfam12508
526225007918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
526225007919 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
526225007920 FAD binding site [chemical binding]; other site
526225007921 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
526225007922 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
526225007923 substrate binding pocket [chemical binding]; other site
526225007924 chain length determination region; other site
526225007925 substrate-Mg2+ binding site; other site
526225007926 catalytic residues [active]
526225007927 aspartate-rich region 1; other site
526225007928 active site lid residues [active]
526225007929 aspartate-rich region 2; other site
526225007930 phytoene desaturase; Region: crtI_fam; TIGR02734
526225007931 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
526225007932 active site lid residues [active]
526225007933 substrate binding pocket [chemical binding]; other site
526225007934 catalytic residues [active]
526225007935 substrate-Mg2+ binding site; other site
526225007936 aspartate-rich region 1; other site
526225007937 aspartate-rich region 2; other site
526225007938 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
526225007939 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
526225007940 Helix-turn-helix domain; Region: HTH_17; pfam12728
526225007941 serine hydroxymethyltransferase; Provisional; Region: PRK13580
526225007942 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
526225007943 dimer interface [polypeptide binding]; other site
526225007944 active site
526225007945 glycine-pyridoxal phosphate binding site [chemical binding]; other site
526225007946 folate binding site [chemical binding]; other site
526225007947 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526225007948 Catalytic domain of Protein Kinases; Region: PKc; cd00180
526225007949 active site
526225007950 ATP binding site [chemical binding]; other site
526225007951 substrate binding site [chemical binding]; other site
526225007952 activation loop (A-loop); other site
526225007953 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
526225007954 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
526225007955 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
526225007956 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
526225007957 AP endonuclease family 2; Region: AP2Ec; smart00518
526225007958 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
526225007959 AP (apurinic/apyrimidinic) site pocket; other site
526225007960 DNA interaction; other site
526225007961 Metal-binding active site; metal-binding site
526225007962 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
526225007963 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
526225007964 tetramer interface [polypeptide binding]; other site
526225007965 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225007966 catalytic residue [active]
526225007967 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
526225007968 phosphofructokinase; Region: PFK_mixed; TIGR02483
526225007969 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
526225007970 active site
526225007971 ADP/pyrophosphate binding site [chemical binding]; other site
526225007972 dimerization interface [polypeptide binding]; other site
526225007973 allosteric effector site; other site
526225007974 fructose-1,6-bisphosphate binding site; other site
526225007975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225007976 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
526225007977 NAD(P) binding site [chemical binding]; other site
526225007978 active site
526225007979 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
526225007980 dimerization interface [polypeptide binding]; other site
526225007981 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
526225007982 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
526225007983 dimer interface [polypeptide binding]; other site
526225007984 putative CheW interface [polypeptide binding]; other site
526225007985 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
526225007986 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
526225007987 putative acyl-acceptor binding pocket; other site
526225007988 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
526225007989 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
526225007990 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
526225007991 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
526225007992 putative hydrophobic ligand binding site [chemical binding]; other site
526225007993 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
526225007994 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
526225007995 acyl-activating enzyme (AAE) consensus motif; other site
526225007996 putative AMP binding site [chemical binding]; other site
526225007997 putative active site [active]
526225007998 putative CoA binding site [chemical binding]; other site
526225007999 Peptidase family M48; Region: Peptidase_M48; cl12018
526225008000 NlpC/P60 family; Region: NLPC_P60; cl17555
526225008001 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
526225008002 hypothetical protein; Validated; Region: PRK07883
526225008003 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
526225008004 active site
526225008005 catalytic site [active]
526225008006 substrate binding site [chemical binding]; other site
526225008007 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
526225008008 GIY-YIG motif/motif A; other site
526225008009 active site
526225008010 catalytic site [active]
526225008011 putative DNA binding site [nucleotide binding]; other site
526225008012 metal binding site [ion binding]; metal-binding site
526225008013 Transcriptional regulators [Transcription]; Region: Lrp; COG1522
526225008014 AsnC family; Region: AsnC_trans_reg; pfam01037
526225008015 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
526225008016 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
526225008017 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
526225008018 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
526225008019 Subunit I/III interface [polypeptide binding]; other site
526225008020 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
526225008021 Cytochrome c; Region: Cytochrom_C; pfam00034
526225008022 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
526225008023 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
526225008024 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
526225008025 iron-sulfur cluster [ion binding]; other site
526225008026 [2Fe-2S] cluster binding site [ion binding]; other site
526225008027 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
526225008028 heme bH binding site [chemical binding]; other site
526225008029 intrachain domain interface; other site
526225008030 heme bL binding site [chemical binding]; other site
526225008031 interchain domain interface [polypeptide binding]; other site
526225008032 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
526225008033 Qo binding site; other site
526225008034 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
526225008035 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
526225008036 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
526225008037 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
526225008038 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
526225008039 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712
526225008040 active site
526225008041 dimer interface [polypeptide binding]; other site
526225008042 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991
526225008043 Ligand Binding Site [chemical binding]; other site
526225008044 Molecular Tunnel; other site
526225008045 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
526225008046 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
526225008047 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526225008048 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526225008049 active site
526225008050 catalytic tetrad [active]
526225008051 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
526225008052 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
526225008053 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019
526225008054 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
526225008055 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
526225008056 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
526225008057 multifunctional aminopeptidase A; Provisional; Region: PRK00913
526225008058 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
526225008059 interface (dimer of trimers) [polypeptide binding]; other site
526225008060 Substrate-binding/catalytic site; other site
526225008061 Zn-binding sites [ion binding]; other site
526225008062 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
526225008063 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526225008064 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
526225008065 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
526225008066 E3 interaction surface; other site
526225008067 lipoyl attachment site [posttranslational modification]; other site
526225008068 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
526225008069 E3 interaction surface; other site
526225008070 lipoyl attachment site [posttranslational modification]; other site
526225008071 e3 binding domain; Region: E3_binding; pfam02817
526225008072 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
526225008073 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
526225008074 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225008075 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
526225008076 NAD(P) binding site [chemical binding]; other site
526225008077 active site
526225008078 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526225008079 Protein Kinases, catalytic domain; Region: PKc_like; cl09925
526225008080 active site
526225008081 ATP binding site [chemical binding]; other site
526225008082 substrate binding site [chemical binding]; other site
526225008083 Protein Kinases, catalytic domain; Region: PKc_like; cl09925
526225008084 substrate binding site [chemical binding]; other site
526225008085 activation loop (A-loop); other site
526225008086 activation loop (A-loop); other site
526225008087 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526225008088 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
526225008089 active site pocket [active]
526225008090 oxyanion hole [active]
526225008091 catalytic triad [active]
526225008092 active site nucleophile [active]
526225008093 lipoate-protein ligase B; Provisional; Region: PRK14345
526225008094 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
526225008095 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
526225008096 active site
526225008097 HIGH motif; other site
526225008098 nucleotide binding site [chemical binding]; other site
526225008099 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
526225008100 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
526225008101 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
526225008102 active site
526225008103 KMSKS motif; other site
526225008104 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
526225008105 tRNA binding surface [nucleotide binding]; other site
526225008106 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199
526225008107 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
526225008108 metal binding site [ion binding]; metal-binding site
526225008109 active site
526225008110 I-site; other site
526225008111 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
526225008112 lipoyl synthase; Provisional; Region: PRK05481
526225008113 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526225008114 FeS/SAM binding site; other site
526225008115 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
526225008116 RDD family; Region: RDD; pfam06271
526225008117 glutamine synthetase, type I; Region: GlnA; TIGR00653
526225008118 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
526225008119 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
526225008120 hypothetical protein; Provisional; Region: PRK07208
526225008121 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526225008122 Protein of unknown function (DUF466); Region: DUF466; cl01082
526225008123 carbon starvation protein A; Provisional; Region: PRK15015
526225008124 Carbon starvation protein CstA; Region: CstA; pfam02554
526225008125 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
526225008126 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
526225008127 substrate binding site [chemical binding]; other site
526225008128 THF binding site; other site
526225008129 zinc-binding site [ion binding]; other site
526225008130 Uncharacterized conserved protein [Function unknown]; Region: COG3189
526225008131 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235
526225008132 intersubunit interface [polypeptide binding]; other site
526225008133 active site
526225008134 Zn2+ binding site [ion binding]; other site
526225008135 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
526225008136 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
526225008137 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
526225008138 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
526225008139 putative dimer interface [polypeptide binding]; other site
526225008140 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196
526225008141 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
526225008142 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
526225008143 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
526225008144 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
526225008145 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799
526225008146 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
526225008147 FAD binding domain; Region: FAD_binding_4; pfam01565
526225008148 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390
526225008149 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
526225008150 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
526225008151 putative active site [active]
526225008152 putative metal binding site [ion binding]; other site
526225008153 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
526225008154 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
526225008155 classical (c) SDRs; Region: SDR_c; cd05233
526225008156 NAD(P) binding site [chemical binding]; other site
526225008157 active site
526225008158 GAF domain; Region: GAF; cl17456
526225008159 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
526225008160 dimer interface [polypeptide binding]; other site
526225008161 putative CheW interface [polypeptide binding]; other site
526225008162 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
526225008163 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
526225008164 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
526225008165 metal binding triad; other site
526225008166 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
526225008167 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
526225008168 metal binding triad; other site
526225008169 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
526225008170 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
526225008171 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
526225008172 catalytic triad [active]
526225008173 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
526225008174 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
526225008175 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
526225008176 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
526225008177 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
526225008178 NAD synthetase; Provisional; Region: PRK13981
526225008179 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
526225008180 multimer interface [polypeptide binding]; other site
526225008181 active site
526225008182 catalytic triad [active]
526225008183 protein interface 1 [polypeptide binding]; other site
526225008184 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
526225008185 homodimer interface [polypeptide binding]; other site
526225008186 NAD binding pocket [chemical binding]; other site
526225008187 ATP binding pocket [chemical binding]; other site
526225008188 Mg binding site [ion binding]; other site
526225008189 active-site loop [active]
526225008190 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
526225008191 oligomerization interface [polypeptide binding]; other site
526225008192 active site
526225008193 metal binding site [ion binding]; metal-binding site
526225008194 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
526225008195 Cupin domain; Region: Cupin_2; pfam07883
526225008196 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199
526225008197 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
526225008198 metal binding site [ion binding]; metal-binding site
526225008199 active site
526225008200 I-site; other site
526225008201 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
526225008202 active site
526225008203 short chain dehydrogenase; Provisional; Region: PRK07109
526225008204 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
526225008205 putative NAD(P) binding site [chemical binding]; other site
526225008206 active site
526225008207 TIR domain; Region: TIR_2; pfam13676
526225008208 ChaB; Region: ChaB; pfam06150
526225008209 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
526225008210 GAF domain; Region: GAF_2; pfam13185
526225008211 GAF domain; Region: GAF; cl17456
526225008212 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199
526225008213 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
526225008214 metal binding site [ion binding]; metal-binding site
526225008215 active site
526225008216 I-site; other site
526225008217 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526225008218 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
526225008219 active site
526225008220 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
526225008221 peptide chain release factor 1; Provisional; Region: PRK04011
526225008222 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
526225008223 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
526225008224 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
526225008225 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
526225008226 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
526225008227 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
526225008228 ATP binding site [chemical binding]; other site
526225008229 Walker A motif; other site
526225008230 hexamer interface [polypeptide binding]; other site
526225008231 Walker B motif; other site
526225008232 AAA domain; Region: AAA_31; pfam13614
526225008233 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
526225008234 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
526225008235 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
526225008236 TadE-like protein; Region: TadE; pfam07811
526225008237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225008238 putative substrate translocation pore; other site
526225008239 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
526225008240 Uncharacterized conserved protein [Function unknown]; Region: COG0397
526225008241 hypothetical protein; Validated; Region: PRK00029
526225008242 GAF domain; Region: GAF; pfam01590
526225008243 ANTAR domain; Region: ANTAR; pfam03861
526225008244 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
526225008245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225008246 Mg2+ binding site [ion binding]; other site
526225008247 G-X-G motif; other site
526225008248 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225008249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225008250 active site
526225008251 phosphorylation site [posttranslational modification]
526225008252 intermolecular recognition site; other site
526225008253 dimerization interface [polypeptide binding]; other site
526225008254 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225008255 DNA binding residues [nucleotide binding]
526225008256 dimerization interface [polypeptide binding]; other site
526225008257 Coenzyme A transferase; Region: CoA_trans; smart00882
526225008258 Coenzyme A transferase; Region: CoA_trans; cl17247
526225008259 Citrate transporter; Region: CitMHS; pfam03600
526225008260 fructuronate transporter; Provisional; Region: PRK10034; cl15264
526225008261 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
526225008262 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
526225008263 RibD C-terminal domain; Region: RibD_C; cl17279
526225008264 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
526225008265 FOG: WD40 repeat [General function prediction only]; Region: COG2319
526225008266 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
526225008267 structural tetrad; other site
526225008268 FOG: WD40 repeat [General function prediction only]; Region: COG2319
526225008269 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
526225008270 structural tetrad; other site
526225008271 Lsr2; Region: Lsr2; pfam11774
526225008272 DDE superfamily endonuclease; Region: DDE_4; pfam13359
526225008273 TIR domain; Region: TIR_2; pfam13676
526225008274 FOG: WD40 repeat [General function prediction only]; Region: COG2319
526225008275 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
526225008276 structural tetrad; other site
526225008277 FOG: WD40 repeat [General function prediction only]; Region: COG2319
526225008278 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
526225008279 structural tetrad; other site
526225008280 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
526225008281 structural tetrad; other site
526225008282 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
526225008283 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
526225008284 nucleoside/Zn binding site; other site
526225008285 dimer interface [polypeptide binding]; other site
526225008286 catalytic motif [active]
526225008287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
526225008288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225008289 S-adenosylmethionine binding site [chemical binding]; other site
526225008290 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526225008291 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
526225008292 Sulfite exporter TauE/SafE; Region: TauE; pfam01925
526225008293 quinolinate synthetase; Provisional; Region: PRK09375
526225008294 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
526225008295 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
526225008296 RNA/DNA hybrid binding site [nucleotide binding]; other site
526225008297 active site
526225008298 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526225008299 catalytic core [active]
526225008300 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
526225008301 Putative zinc ribbon domain; Region: DUF164; pfam02591
526225008302 Uncharacterized conserved protein [Function unknown]; Region: COG0327
526225008303 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
526225008304 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
526225008305 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526225008306 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526225008307 TAP-like protein; Region: Abhydrolase_4; pfam08386
526225008308 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
526225008309 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
526225008310 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
526225008311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225008312 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
526225008313 NAD(P) binding site [chemical binding]; other site
526225008314 active site
526225008315 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526225008316 Serine hydrolase; Region: Ser_hydrolase; cl17834
526225008317 Secretory lipase; Region: LIP; pfam03583
526225008318 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526225008319 PGAP1-like protein; Region: PGAP1; pfam07819
526225008320 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
526225008321 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
526225008322 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
526225008323 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
526225008324 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526225008325 TPR motif; other site
526225008326 binding surface
526225008327 TPR repeat; Region: TPR_11; pfam13414
526225008328 TIR domain; Region: TIR_2; pfam13676
526225008329 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
526225008330 SIR2-like domain; Region: SIR2_2; pfam13289
526225008331 TIR domain; Region: TIR_2; pfam13676
526225008332 NB-ARC domain; Region: NB-ARC; pfam00931
526225008333 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526225008334 Tetratricopeptide repeat; Region: TPR_12; pfam13424
526225008335 binding surface
526225008336 TPR motif; other site
526225008337 Tetratricopeptide repeat; Region: TPR_12; pfam13424
526225008338 Tetratricopeptide repeat; Region: TPR_12; pfam13424
526225008339 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
526225008340 TPR motif; other site
526225008341 binding surface
526225008342 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509
526225008343 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
526225008344 Protein of unknown function DUF262; Region: DUF262; pfam03235
526225008345 Uncharacterized conserved protein [Function unknown]; Region: COG1479
526225008346 Protein of unknown function DUF262; Region: DUF262; pfam03235
526225008347 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
526225008348 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526225008349 salt bridge; other site
526225008350 non-specific DNA binding site [nucleotide binding]; other site
526225008351 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526225008352 sequence-specific DNA binding site [nucleotide binding]; other site
526225008353 short chain dehydrogenase; Provisional; Region: PRK06180
526225008354 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
526225008355 NADP binding site [chemical binding]; other site
526225008356 active site
526225008357 steroid binding site; other site
526225008358 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
526225008359 active site
526225008360 Int/Topo IB signature motif; other site
526225008361 DNA binding site [nucleotide binding]
526225008362 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
526225008363 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
526225008364 dimer interface [polypeptide binding]; other site
526225008365 catalytic triad [active]
526225008366 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
526225008367 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
526225008368 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
526225008369 dimer interface [polypeptide binding]; other site
526225008370 TPP-binding site [chemical binding]; other site
526225008371 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
526225008372 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
526225008373 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
526225008374 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
526225008375 metal binding site [ion binding]; metal-binding site
526225008376 dimer interface [polypeptide binding]; other site
526225008377 Pirin; Region: Pirin; pfam02678
526225008378 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
526225008379 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
526225008380 active site
526225008381 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
526225008382 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
526225008383 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
526225008384 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
526225008385 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
526225008386 carboxyltransferase (CT) interaction site; other site
526225008387 biotinylation site [posttranslational modification]; other site
526225008388 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
526225008389 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
526225008390 dimer interface [polypeptide binding]; other site
526225008391 active site
526225008392 CoA binding pocket [chemical binding]; other site
526225008393 acyl carrier protein; Provisional; Region: acpP; PRK00982
526225008394 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
526225008395 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
526225008396 dimer interface [polypeptide binding]; other site
526225008397 active site
526225008398 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
526225008399 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
526225008400 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343
526225008401 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199
526225008402 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
526225008403 metal binding site [ion binding]; metal-binding site
526225008404 active site
526225008405 I-site; other site
526225008406 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
526225008407 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
526225008408 Peptidase family M23; Region: Peptidase_M23; pfam01551
526225008409 PBP superfamily domain; Region: PBP_like_2; cl17296
526225008410 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
526225008411 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
526225008412 active site
526225008413 DNA binding site [nucleotide binding]
526225008414 Int/Topo IB signature motif; other site
526225008415 Helix-turn-helix domain; Region: HTH_17; pfam12728
526225008416 stage V sporulation protein K; Region: spore_V_K; TIGR02881
526225008417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526225008418 Walker A motif; other site
526225008419 ATP binding site [chemical binding]; other site
526225008420 Walker B motif; other site
526225008421 arginine finger; other site
526225008422 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
526225008423 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
526225008424 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
526225008425 Transposase; Region: DEDD_Tnp_IS110; pfam01548
526225008426 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
526225008427 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
526225008428 DDE superfamily endonuclease; Region: DDE_5; pfam13546
526225008429 DDE superfamily endonuclease; Region: DDE_4; pfam13359
526225008430 Homeodomain-like domain; Region: HTH_23; pfam13384
526225008431 Winged helix-turn helix; Region: HTH_29; pfam13551
526225008432 Homeodomain-like domain; Region: HTH_32; pfam13565
526225008433 DDE superfamily endonuclease; Region: DDE_3; pfam13358
526225008434 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
526225008435 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
526225008436 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
526225008437 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526225008438 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526225008439 active site
526225008440 catalytic tetrad [active]
526225008441 Cupin domain; Region: Cupin_2; cl17218
526225008442 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822
526225008443 putative hydrophobic ligand binding site [chemical binding]; other site
526225008444 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
526225008445 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
526225008446 putative NAD(P) binding site [chemical binding]; other site
526225008447 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329
526225008448 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
526225008449 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225008450 Walker A/P-loop; other site
526225008451 ATP binding site [chemical binding]; other site
526225008452 Q-loop/lid; other site
526225008453 ABC transporter signature motif; other site
526225008454 Walker B; other site
526225008455 D-loop; other site
526225008456 H-loop/switch region; other site
526225008457 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526225008458 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225008459 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
526225008460 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
526225008461 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
526225008462 putative NAD(P) binding site [chemical binding]; other site
526225008463 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526225008464 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
526225008465 catalytic site [active]
526225008466 DDE superfamily endonuclease; Region: DDE_4; pfam13359
526225008467 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
526225008468 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
526225008469 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
526225008470 VanW like protein; Region: VanW; pfam04294
526225008471 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
526225008472 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
526225008473 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
526225008474 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
526225008475 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
526225008476 ATP binding site [chemical binding]; other site
526225008477 substrate binding site [chemical binding]; other site
526225008478 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
526225008479 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
526225008480 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cl00253
526225008481 putative active site [active]
526225008482 dimerization interface [polypeptide binding]; other site
526225008483 putative tRNAtyr binding site [nucleotide binding]; other site
526225008484 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
526225008485 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
526225008486 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526225008487 Sigma-70 region 3; Region: Sigma70_r3; pfam04539
526225008488 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526225008489 DNA binding residues [nucleotide binding]
526225008490 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
526225008491 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526225008492 Coenzyme A binding pocket [chemical binding]; other site
526225008493 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
526225008494 CoA binding domain; Region: CoA_binding_2; pfam13380
526225008495 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
526225008496 ATP-grasp domain; Region: ATP-grasp_5; pfam13549
526225008497 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
526225008498 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
526225008499 active site
526225008500 Zn binding site [ion binding]; other site
526225008501 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
526225008502 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
526225008503 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
526225008504 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
526225008505 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
526225008506 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
526225008507 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
526225008508 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
526225008509 catalytic residues [active]
526225008510 catalytic nucleophile [active]
526225008511 Recombinase; Region: Recombinase; pfam07508
526225008512 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
526225008513 Helix-turn-helix domain; Region: HTH_36; pfam13730
526225008514 Phage capsid family; Region: Phage_capsid; pfam05065
526225008515 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
526225008516 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
526225008517 Protein of unknown function (DUF1211); Region: DUF1211; cl01421
526225008518 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
526225008519 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
526225008520 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526225008521 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
526225008522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225008523 S-adenosylmethionine binding site [chemical binding]; other site
526225008524 Protein of unknown function, DUF608; Region: DUF608; pfam04685
526225008525 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
526225008526 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
526225008527 Probable Catalytic site; other site
526225008528 metal-binding site
526225008529 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
526225008530 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
526225008531 Probable Catalytic site; other site
526225008532 metal-binding site
526225008533 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
526225008534 Methyltransferase domain; Region: Methyltransf_24; pfam13578
526225008535 YibE/F-like protein; Region: YibE_F; pfam07907
526225008536 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
526225008537 anti sigma factor interaction site; other site
526225008538 regulatory phosphorylation site [posttranslational modification]; other site
526225008539 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
526225008540 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
526225008541 putative dimer interface [polypeptide binding]; other site
526225008542 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
526225008543 MerR HTH family regulatory protein; Region: MerR_1; pfam13411
526225008544 DNA binding residues [nucleotide binding]
526225008545 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
526225008546 putative homodimer interface [polypeptide binding]; other site
526225008547 putative homotetramer interface [polypeptide binding]; other site
526225008548 putative allosteric switch controlling residues; other site
526225008549 putative metal binding site [ion binding]; other site
526225008550 putative homodimer-homodimer interface [polypeptide binding]; other site
526225008551 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
526225008552 metal-binding site [ion binding]
526225008553 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
526225008554 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
526225008555 metal-binding site [ion binding]
526225008556 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
526225008557 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
526225008558 Epoxide hydrolase N terminus; Region: EHN; pfam06441
526225008559 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526225008560 Penicillinase repressor; Region: Pencillinase_R; cl17580
526225008561 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
526225008562 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
526225008563 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
526225008564 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
526225008565 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
526225008566 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225008567 Walker A/P-loop; other site
526225008568 ATP binding site [chemical binding]; other site
526225008569 Q-loop/lid; other site
526225008570 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225008571 Walker A/P-loop; other site
526225008572 ATP binding site [chemical binding]; other site
526225008573 Q-loop/lid; other site
526225008574 ABC transporter signature motif; other site
526225008575 Walker B; other site
526225008576 D-loop; other site
526225008577 H-loop/switch region; other site
526225008578 RibD C-terminal domain; Region: RibD_C; cl17279
526225008579 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
526225008580 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
526225008581 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
526225008582 tartrate dehydrogenase; Region: TTC; TIGR02089
526225008583 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
526225008584 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
526225008585 NAD(P) binding site [chemical binding]; other site
526225008586 catalytic residues [active]
526225008587 Cupin domain; Region: Cupin_2; pfam07883
526225008588 Uncharacterized conserved protein [Function unknown]; Region: COG1359
526225008589 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
526225008590 Transcriptional regulators [Transcription]; Region: GntR; COG1802
526225008591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526225008592 DNA-binding site [nucleotide binding]; DNA binding site
526225008593 FCD domain; Region: FCD; pfam07729
526225008594 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
526225008595 Ligand Binding Site [chemical binding]; other site
526225008596 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
526225008597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225008598 intermolecular recognition site; other site
526225008599 active site
526225008600 dimerization interface [polypeptide binding]; other site
526225008601 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
526225008602 PAS domain; Region: PAS; smart00091
526225008603 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225008604 ATP binding site [chemical binding]; other site
526225008605 Mg2+ binding site [ion binding]; other site
526225008606 G-X-G motif; other site
526225008607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
526225008608 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
526225008609 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
526225008610 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
526225008611 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
526225008612 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
526225008613 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
526225008614 ethanolamine permease; Region: 2A0305; TIGR00908
526225008615 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
526225008616 GAF domain; Region: GAF; pfam01590
526225008617 ANTAR domain; Region: ANTAR; pfam03861
526225008618 classical (c) SDRs; Region: SDR_c; cd05233
526225008619 NAD(P) binding site [chemical binding]; other site
526225008620 active site
526225008621 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
526225008622 putative active site [active]
526225008623 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041
526225008624 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
526225008625 putative active site [active]
526225008626 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
526225008627 active site
526225008628 dimer interface [polypeptide binding]; other site
526225008629 motif 2; other site
526225008630 motif 3; other site
526225008631 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
526225008632 Domain of unknown function (DUF222); Region: DUF222; pfam02720
526225008633 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
526225008634 active site
526225008635 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526225008636 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
526225008637 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225008638 NAD(P) binding site [chemical binding]; other site
526225008639 active site
526225008640 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
526225008641 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
526225008642 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
526225008643 Walker A/P-loop; other site
526225008644 ATP binding site [chemical binding]; other site
526225008645 Q-loop/lid; other site
526225008646 ABC transporter signature motif; other site
526225008647 Walker B; other site
526225008648 D-loop; other site
526225008649 H-loop/switch region; other site
526225008650 TOBE domain; Region: TOBE_2; pfam08402
526225008651 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
526225008652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526225008653 dimer interface [polypeptide binding]; other site
526225008654 conserved gate region; other site
526225008655 ABC-ATPase subunit interface; other site
526225008656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526225008657 dimer interface [polypeptide binding]; other site
526225008658 conserved gate region; other site
526225008659 ABC-ATPase subunit interface; other site
526225008660 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
526225008661 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
526225008662 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
526225008663 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021
526225008664 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; cl02333
526225008665 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
526225008666 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526225008667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
526225008668 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583
526225008669 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
526225008670 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
526225008671 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
526225008672 CoenzymeA binding site [chemical binding]; other site
526225008673 subunit interaction site [polypeptide binding]; other site
526225008674 PHB binding site; other site
526225008675 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
526225008676 FAD binding domain; Region: FAD_binding_4; pfam01565
526225008677 Berberine and berberine like; Region: BBE; pfam08031
526225008678 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
526225008679 nudix motif; other site
526225008680 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
526225008681 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526225008682 substrate binding site [chemical binding]; other site
526225008683 oxyanion hole (OAH) forming residues; other site
526225008684 trimer interface [polypeptide binding]; other site
526225008685 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
526225008686 Part of AAA domain; Region: AAA_19; pfam13245
526225008687 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
526225008688 AAA domain; Region: AAA_12; pfam13087
526225008689 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
526225008690 homotetrameric interface [polypeptide binding]; other site
526225008691 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
526225008692 Catalytic domain of Protein Kinases; Region: PKc; cd00180
526225008693 active site
526225008694 ATP binding site [chemical binding]; other site
526225008695 substrate binding site [chemical binding]; other site
526225008696 activation loop (A-loop); other site
526225008697 PAS fold; Region: PAS_2; pfam08446
526225008698 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
526225008699 GAF domain; Region: GAF; pfam01590
526225008700 Phytochrome region; Region: PHY; pfam00360
526225008701 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
526225008702 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
526225008703 anti sigma factor interaction site; other site
526225008704 regulatory phosphorylation site [posttranslational modification]; other site
526225008705 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
526225008706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
526225008707 ATP binding site [chemical binding]; other site
526225008708 Mg2+ binding site [ion binding]; other site
526225008709 G-X-G motif; other site
526225008710 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526225008711 Catalytic domain of Protein Kinases; Region: PKc; cd00180
526225008712 active site
526225008713 ATP binding site [chemical binding]; other site
526225008714 substrate binding site [chemical binding]; other site
526225008715 activation loop (A-loop); other site
526225008716 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
526225008717 hypothetical protein; Reviewed; Region: PRK09588
526225008718 Cupin domain; Region: Cupin_2; pfam07883
526225008719 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
526225008720 anti sigma factor interaction site; other site
526225008721 regulatory phosphorylation site [posttranslational modification]; other site
526225008722 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557
526225008723 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
526225008724 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
526225008725 Strictosidine synthase; Region: Str_synth; pfam03088
526225008726 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
526225008727 dimerization interface [polypeptide binding]; other site
526225008728 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
526225008729 NAD binding site [chemical binding]; other site
526225008730 ligand binding site [chemical binding]; other site
526225008731 catalytic site [active]
526225008732 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
526225008733 nudix motif; other site
526225008734 Uncharacterized conserved protein [General function prediction only]; Region: COG4111
526225008735 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
526225008736 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
526225008737 active site
526225008738 catalytic residues [active]
526225008739 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
526225008740 HD domain; Region: HD_4; pfam13328
526225008741 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
526225008742 pfkB family carbohydrate kinase; Region: PfkB; pfam00294
526225008743 substrate binding site [chemical binding]; other site
526225008744 ATP binding site [chemical binding]; other site
526225008745 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
526225008746 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526225008747 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
526225008748 oligomeric interface; other site
526225008749 putative active site [active]
526225008750 homodimer interface [polypeptide binding]; other site
526225008751 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
526225008752 RNase_H superfamily; Region: RNase_H_2; pfam13482
526225008753 AAA domain; Region: AAA_30; pfam13604
526225008754 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
526225008755 AAA domain; Region: AAA_12; pfam13087
526225008756 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
526225008757 putative active site [active]
526225008758 homotetrameric interface [polypeptide binding]; other site
526225008759 metal binding site [ion binding]; metal-binding site
526225008760 Cupin domain; Region: Cupin_2; cl17218
526225008761 Domain of unknown function (DUF385); Region: DUF385; cl04387
526225008762 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
526225008763 putative catalytic site [active]
526225008764 putative metal binding site [ion binding]; other site
526225008765 putative phosphate binding site [ion binding]; other site
526225008766 Cupin domain; Region: Cupin_2; pfam07883
526225008767 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
526225008768 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284
526225008769 NAD binding site [chemical binding]; other site
526225008770 substrate binding site [chemical binding]; other site
526225008771 catalytic Zn binding site [ion binding]; other site
526225008772 structural Zn binding site [ion binding]; other site
526225008773 Cupin domain; Region: Cupin_2; cl17218
526225008774 PemK-like protein; Region: PemK; pfam02452
526225008775 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
526225008776 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
526225008777 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
526225008778 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
526225008779 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440
526225008780 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
526225008781 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526225008782 putative Zn2+ binding site [ion binding]; other site
526225008783 putative DNA binding site [nucleotide binding]; other site
526225008784 dimerization interface [polypeptide binding]; other site
526225008785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
526225008786 Organiser of macrodomain of Terminus of chromosome; Region: MatP; cl11476
526225008787 Fic/DOC family; Region: Fic; cl00960
526225008788 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
526225008789 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
526225008790 active site
526225008791 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
526225008792 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
526225008793 putative catalytic site [active]
526225008794 putative metal binding site [ion binding]; other site
526225008795 putative phosphate binding site [ion binding]; other site
526225008796 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203
526225008797 PLD-like domain; Region: PLDc_2; pfam13091
526225008798 putative homodimer interface [polypeptide binding]; other site
526225008799 putative active site [active]
526225008800 catalytic site [active]
526225008801 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
526225008802 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526225008803 ATP binding site [chemical binding]; other site
526225008804 putative Mg++ binding site [ion binding]; other site
526225008805 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526225008806 nucleotide binding region [chemical binding]; other site
526225008807 ATP-binding site [chemical binding]; other site
526225008808 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
526225008809 Part of AAA domain; Region: AAA_19; pfam13245
526225008810 Family description; Region: UvrD_C_2; pfam13538
526225008811 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
526225008812 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526225008813 ATP binding site [chemical binding]; other site
526225008814 putative Mg++ binding site [ion binding]; other site
526225008815 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526225008816 ATP-binding site [chemical binding]; other site
526225008817 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
526225008818 N-6 DNA Methylase; Region: N6_Mtase; pfam02384
526225008819 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
526225008820 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526225008821 ATP binding site [chemical binding]; other site
526225008822 putative Mg++ binding site [ion binding]; other site
526225008823 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526225008824 nucleotide binding region [chemical binding]; other site
526225008825 ATP-binding site [chemical binding]; other site
526225008826 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849
526225008827 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
526225008828 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
526225008829 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526225008830 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
526225008831 acyl-activating enzyme (AAE) consensus motif; other site
526225008832 acyl-activating enzyme (AAE) consensus motif; other site
526225008833 putative AMP binding site [chemical binding]; other site
526225008834 putative active site [active]
526225008835 putative CoA binding site [chemical binding]; other site
526225008836 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
526225008837 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
526225008838 PAS domain S-box; Region: sensory_box; TIGR00229
526225008839 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
526225008840 putative active site [active]
526225008841 heme pocket [chemical binding]; other site
526225008842 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199
526225008843 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
526225008844 metal binding site [ion binding]; metal-binding site
526225008845 active site
526225008846 I-site; other site
526225008847 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
526225008848 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
526225008849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225008850 S-adenosylmethionine binding site [chemical binding]; other site
526225008851 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
526225008852 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
526225008853 putative active site [active]
526225008854 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
526225008855 ABC1 family; Region: ABC1; pfam03109
526225008856 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
526225008857 active site
526225008858 ATP binding site [chemical binding]; other site
526225008859 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
526225008860 FMN binding site [chemical binding]; other site
526225008861 substrate binding site [chemical binding]; other site
526225008862 putative catalytic residue [active]
526225008863 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
526225008864 Uncharacterized conserved protein [Function unknown]; Region: COG3391
526225008865 Fic family protein [Function unknown]; Region: COG3177
526225008866 Fic/DOC family; Region: Fic; pfam02661
526225008867 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526225008868 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
526225008869 TIGR03086 family protein; Region: TIGR03086
526225008870 Transglycosylase; Region: Transgly; pfam00912
526225008871 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
526225008872 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526225008873 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526225008874 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526225008875 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526225008876 active site
526225008877 enoyl-CoA hydratase; Provisional; Region: PRK05870
526225008878 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526225008879 substrate binding site [chemical binding]; other site
526225008880 oxyanion hole (OAH) forming residues; other site
526225008881 trimer interface [polypeptide binding]; other site
526225008882 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
526225008883 CoA binding domain; Region: CoA_binding_2; pfam13380
526225008884 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
526225008885 ATP-grasp domain; Region: ATP-grasp_5; pfam13549
526225008886 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526225008887 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225008888 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
526225008889 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
526225008890 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
526225008891 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
526225008892 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
526225008893 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
526225008894 putative NAD(P) binding site [chemical binding]; other site
526225008895 putative active site [active]
526225008896 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
526225008897 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
526225008898 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
526225008899 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
526225008900 inhibitor site; inhibition site
526225008901 active site
526225008902 dimer interface [polypeptide binding]; other site
526225008903 catalytic residue [active]
526225008904 hydroxyglutarate oxidase; Provisional; Region: PRK11728
526225008905 Predicted dehydrogenase [General function prediction only]; Region: COG0579
526225008906 Domain of unknown function (DUF222); Region: DUF222; pfam02720
526225008907 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
526225008908 active site
526225008909 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130
526225008910 hypothetical protein; Validated; Region: PRK06201
526225008911 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
526225008912 tartrate dehydrogenase; Provisional; Region: PRK08194
526225008913 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
526225008914 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
526225008915 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
526225008916 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
526225008917 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
526225008918 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526225008919 DNA-binding site [nucleotide binding]; DNA binding site
526225008920 Transcriptional regulators [Transcription]; Region: FadR; COG2186
526225008921 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
526225008922 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
526225008923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225008924 NAD(P) binding site [chemical binding]; other site
526225008925 active site
526225008926 monocarboxylate transporter 1; Region: 2A0113; TIGR00892
526225008927 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
526225008928 CoA-transferase family III; Region: CoA_transf_3; pfam02515
526225008929 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
526225008930 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
526225008931 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
526225008932 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
526225008933 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
526225008934 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
526225008935 putative dimer interface [polypeptide binding]; other site
526225008936 N-terminal domain interface [polypeptide binding]; other site
526225008937 putative substrate binding pocket (H-site) [chemical binding]; other site
526225008938 Excalibur calcium-binding domain; Region: Excalibur; smart00894
526225008939 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
526225008940 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
526225008941 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
526225008942 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526225008943 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526225008944 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526225008945 active site
526225008946 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
526225008947 PAS domain; Region: PAS_9; pfam13426
526225008948 putative active site [active]
526225008949 heme pocket [chemical binding]; other site
526225008950 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
526225008951 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
526225008952 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
526225008953 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526225008954 Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB...; Region: CYCLIN; cl00050
526225008955 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
526225008956 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526225008957 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
526225008958 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
526225008959 Part of AAA domain; Region: AAA_19; pfam13245
526225008960 Family description; Region: UvrD_C_2; pfam13538
526225008961 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
526225008962 Cytochrome P450; Region: p450; cl12078
526225008963 SIR2-like domain; Region: SIR2_2; pfam13289
526225008964 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
526225008965 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
526225008966 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
526225008967 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
526225008968 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
526225008969 Predicted membrane protein [Function unknown]; Region: COG4325
526225008970 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
526225008971 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225008972 NAD(P) binding site [chemical binding]; other site
526225008973 active site
526225008974 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
526225008975 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
526225008976 dimer interface [polypeptide binding]; other site
526225008977 active site
526225008978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225008979 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
526225008980 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
526225008981 ligand binding site [chemical binding]; other site
526225008982 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
526225008983 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
526225008984 TM-ABC transporter signature motif; other site
526225008985 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
526225008986 TM-ABC transporter signature motif; other site
526225008987 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
526225008988 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
526225008989 Walker A/P-loop; other site
526225008990 ATP binding site [chemical binding]; other site
526225008991 Q-loop/lid; other site
526225008992 ABC transporter signature motif; other site
526225008993 Walker B; other site
526225008994 D-loop; other site
526225008995 H-loop/switch region; other site
526225008996 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
526225008997 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
526225008998 Walker A/P-loop; other site
526225008999 ATP binding site [chemical binding]; other site
526225009000 Q-loop/lid; other site
526225009001 ABC transporter signature motif; other site
526225009002 Walker B; other site
526225009003 D-loop; other site
526225009004 H-loop/switch region; other site
526225009005 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
526225009006 anti sigma factor interaction site; other site
526225009007 regulatory phosphorylation site [posttranslational modification]; other site
526225009008 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
526225009009 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
526225009010 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
526225009011 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
526225009012 NAD(P) binding site [chemical binding]; other site
526225009013 catalytic residues [active]
526225009014 choline dehydrogenase; Validated; Region: PRK02106
526225009015 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
526225009016 Major Facilitator Superfamily; Region: MFS_1; pfam07690
526225009017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225009018 putative substrate translocation pore; other site
526225009019 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
526225009020 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
526225009021 conserved cys residue [active]
526225009022 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526225009023 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
526225009024 DEAD-like helicases superfamily; Region: DEXDc; smart00487
526225009025 ATP binding site [chemical binding]; other site
526225009026 putative Mg++ binding site [ion binding]; other site
526225009027 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526225009028 nucleotide binding region [chemical binding]; other site
526225009029 ATP-binding site [chemical binding]; other site
526225009030 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
526225009031 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
526225009032 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
526225009033 Metal-binding active site; metal-binding site
526225009034 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
526225009035 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526225009036 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526225009037 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
526225009038 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
526225009039 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
526225009040 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526225009041 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
526225009042 TM-ABC transporter signature motif; other site
526225009043 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
526225009044 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
526225009045 Walker A/P-loop; other site
526225009046 ATP binding site [chemical binding]; other site
526225009047 Q-loop/lid; other site
526225009048 ABC transporter signature motif; other site
526225009049 Walker B; other site
526225009050 D-loop; other site
526225009051 H-loop/switch region; other site
526225009052 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
526225009053 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
526225009054 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
526225009055 nucleotide binding site [chemical binding]; other site
526225009056 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526225009057 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
526225009058 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526225009059 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526225009060 putative hydrolase; Provisional; Region: PRK11460
526225009061 Predicted esterase [General function prediction only]; Region: COG0400
526225009062 Erythromycin esterase; Region: Erythro_esteras; pfam05139
526225009063 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
526225009064 classical (c) SDRs; Region: SDR_c; cd05233
526225009065 NAD(P) binding site [chemical binding]; other site
526225009066 active site
526225009067 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
526225009068 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324
526225009069 trehalose synthase; Region: treS_nterm; TIGR02456
526225009070 active site
526225009071 catalytic site [active]
526225009072 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
526225009073 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
526225009074 protein binding site [polypeptide binding]; other site
526225009075 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199
526225009076 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
526225009077 metal binding site [ion binding]; metal-binding site
526225009078 active site
526225009079 I-site; other site
526225009080 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
526225009081 oxidoreductase; Provisional; Region: PRK12743
526225009082 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225009083 NAD(P) binding site [chemical binding]; other site
526225009084 active site
526225009085 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
526225009086 HTH domain; Region: HTH_11; cl17392
526225009087 WYL domain; Region: WYL; pfam13280
526225009088 Protein of unknown function (DUF664); Region: DUF664; pfam04978
526225009089 DinB superfamily; Region: DinB_2; pfam12867
526225009090 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
526225009091 putative hydrophobic ligand binding site [chemical binding]; other site
526225009092 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526225009093 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526225009094 active site
526225009095 catalytic tetrad [active]
526225009096 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
526225009097 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526225009098 RibD C-terminal domain; Region: RibD_C; cl17279
526225009099 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526225009100 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225009101 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
526225009102 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
526225009103 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
526225009104 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526225009105 Coenzyme A binding pocket [chemical binding]; other site
526225009106 Uncharacterized conserved protein [Function unknown]; Region: COG4095
526225009107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225009108 Major Facilitator Superfamily; Region: MFS_1; pfam07690
526225009109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225009110 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
526225009111 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
526225009112 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
526225009113 metal-binding site [ion binding]
526225009114 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
526225009115 Soluble P-type ATPase [General function prediction only]; Region: COG4087
526225009116 YtkA-like; Region: YtkA; pfam13115
526225009117 Acetyltransferases [General function prediction only]; Region: RimI; COG0456
526225009118 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526225009119 Coenzyme A binding pocket [chemical binding]; other site
526225009120 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
526225009121 metal-binding site [ion binding]
526225009122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225009123 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
526225009124 putative substrate translocation pore; other site
526225009125 AAA ATPase domain; Region: AAA_16; pfam13191
526225009126 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225009127 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225009128 DNA binding residues [nucleotide binding]
526225009129 dimerization interface [polypeptide binding]; other site
526225009130 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
526225009131 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
526225009132 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556
526225009133 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
526225009134 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
526225009135 active site
526225009136 dimer interface [polypeptide binding]; other site
526225009137 effector binding site; other site
526225009138 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
526225009139 TSCPD domain; Region: TSCPD; pfam12637
526225009140 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
526225009141 ATP cone domain; Region: ATP-cone; pfam03477
526225009142 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
526225009143 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
526225009144 LexA repressor; Validated; Region: PRK00215
526225009145 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
526225009146 Catalytic site [active]
526225009147 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
526225009148 active site
526225009149 GTPases [General function prediction only]; Region: HflX; COG2262
526225009150 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
526225009151 HflX GTPase family; Region: HflX; cd01878
526225009152 G1 box; other site
526225009153 GTP/Mg2+ binding site [chemical binding]; other site
526225009154 Switch I region; other site
526225009155 G2 box; other site
526225009156 G3 box; other site
526225009157 Switch II region; other site
526225009158 G4 box; other site
526225009159 G5 box; other site
526225009160 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
526225009161 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
526225009162 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
526225009163 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
526225009164 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
526225009165 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
526225009166 active site
526225009167 metal binding site [ion binding]; metal-binding site
526225009168 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
526225009169 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
526225009170 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
526225009171 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
526225009172 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
526225009173 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526225009174 FeS/SAM binding site; other site
526225009175 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
526225009176 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
526225009177 Walker A/P-loop; other site
526225009178 ATP binding site [chemical binding]; other site
526225009179 Q-loop/lid; other site
526225009180 ABC transporter signature motif; other site
526225009181 Walker B; other site
526225009182 D-loop; other site
526225009183 H-loop/switch region; other site
526225009184 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
526225009185 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
526225009186 substrate binding pocket [chemical binding]; other site
526225009187 membrane-bound complex binding site; other site
526225009188 hinge residues; other site
526225009189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526225009190 dimer interface [polypeptide binding]; other site
526225009191 conserved gate region; other site
526225009192 putative PBP binding loops; other site
526225009193 ABC-ATPase subunit interface; other site
526225009194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526225009195 dimer interface [polypeptide binding]; other site
526225009196 conserved gate region; other site
526225009197 putative PBP binding loops; other site
526225009198 ABC-ATPase subunit interface; other site
526225009199 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
526225009200 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
526225009201 D-pathway; other site
526225009202 Putative ubiquinol binding site [chemical binding]; other site
526225009203 Low-spin heme (heme b) binding site [chemical binding]; other site
526225009204 Putative water exit pathway; other site
526225009205 Binuclear center (heme o3/CuB) [ion binding]; other site
526225009206 K-pathway; other site
526225009207 Putative proton exit pathway; other site
526225009208 recombination regulator RecX; Reviewed; Region: recX; PRK00117
526225009209 recombinase A; Provisional; Region: recA; PRK09354
526225009210 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
526225009211 hexamer interface [polypeptide binding]; other site
526225009212 Walker A motif; other site
526225009213 ATP binding site [chemical binding]; other site
526225009214 Walker B motif; other site
526225009215 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
526225009216 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526225009217 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526225009218 active site
526225009219 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526225009220 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
526225009221 ATP binding site [chemical binding]; other site
526225009222 putative Mg++ binding site [ion binding]; other site
526225009223 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526225009224 nucleotide binding region [chemical binding]; other site
526225009225 ATP-binding site [chemical binding]; other site
526225009226 DEAD/H associated; Region: DEAD_assoc; pfam08494
526225009227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
526225009228 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
526225009229 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
526225009230 putative DNA binding site [nucleotide binding]; other site
526225009231 catalytic residue [active]
526225009232 putative H2TH interface [polypeptide binding]; other site
526225009233 putative catalytic residues [active]
526225009234 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
526225009235 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
526225009236 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
526225009237 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
526225009238 substrate binding site [chemical binding]; other site
526225009239 ATP binding site [chemical binding]; other site
526225009240 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
526225009241 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
526225009242 Walker A/P-loop; other site
526225009243 ATP binding site [chemical binding]; other site
526225009244 Q-loop/lid; other site
526225009245 ABC transporter signature motif; other site
526225009246 Walker B; other site
526225009247 D-loop; other site
526225009248 H-loop/switch region; other site
526225009249 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
526225009250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526225009251 dimer interface [polypeptide binding]; other site
526225009252 conserved gate region; other site
526225009253 ABC-ATPase subunit interface; other site
526225009254 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
526225009255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526225009256 dimer interface [polypeptide binding]; other site
526225009257 conserved gate region; other site
526225009258 putative PBP binding loops; other site
526225009259 ABC-ATPase subunit interface; other site
526225009260 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
526225009261 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
526225009262 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
526225009263 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
526225009264 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225009265 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
526225009266 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
526225009267 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
526225009268 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526225009269 FeS/SAM binding site; other site
526225009270 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
526225009271 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
526225009272 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
526225009273 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645
526225009274 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526225009275 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526225009276 DNA binding residues [nucleotide binding]
526225009277 Putative zinc-finger; Region: zf-HC2; pfam13490
526225009278 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
526225009279 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
526225009280 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
526225009281 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
526225009282 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
526225009283 dimer interface [polypeptide binding]; other site
526225009284 active site
526225009285 catalytic residue [active]
526225009286 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
526225009287 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
526225009288 folate binding site [chemical binding]; other site
526225009289 NADP+ binding site [chemical binding]; other site
526225009290 thymidylate synthase; Reviewed; Region: thyA; PRK01827
526225009291 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
526225009292 dimerization interface [polypeptide binding]; other site
526225009293 active site
526225009294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
526225009295 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
526225009296 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526225009297 Coenzyme A binding pocket [chemical binding]; other site
526225009298 dihydrodipicolinate reductase; Provisional; Region: PRK00048
526225009299 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
526225009300 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
526225009301 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
526225009302 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
526225009303 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
526225009304 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
526225009305 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
526225009306 RNase E interface [polypeptide binding]; other site
526225009307 trimer interface [polypeptide binding]; other site
526225009308 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
526225009309 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
526225009310 RNase E interface [polypeptide binding]; other site
526225009311 trimer interface [polypeptide binding]; other site
526225009312 active site
526225009313 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
526225009314 putative nucleic acid binding region [nucleotide binding]; other site
526225009315 G-X-X-G motif; other site
526225009316 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
526225009317 RNA binding site [nucleotide binding]; other site
526225009318 domain interface; other site
526225009319 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
526225009320 16S/18S rRNA binding site [nucleotide binding]; other site
526225009321 S13e-L30e interaction site [polypeptide binding]; other site
526225009322 25S rRNA binding site [nucleotide binding]; other site
526225009323 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
526225009324 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
526225009325 active site
526225009326 Riboflavin kinase; Region: Flavokinase; pfam01687
526225009327 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
526225009328 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
526225009329 homodimer interface [polypeptide binding]; other site
526225009330 substrate-cofactor binding pocket; other site
526225009331 catalytic residue [active]
526225009332 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
526225009333 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
526225009334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526225009335 motif II; other site
526225009336 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
526225009337 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
526225009338 RNA binding site [nucleotide binding]; other site
526225009339 active site
526225009340 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
526225009341 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
526225009342 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
526225009343 DHH family; Region: DHH; pfam01368
526225009344 ribosome-binding factor A; Validated; Region: rbfA; PRK00521
526225009345 Protein of unknown function (DUF503); Region: DUF503; pfam04456
526225009346 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
526225009347 translation initiation factor IF-2; Region: IF-2; TIGR00487
526225009348 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
526225009349 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
526225009350 G1 box; other site
526225009351 putative GEF interaction site [polypeptide binding]; other site
526225009352 GTP/Mg2+ binding site [chemical binding]; other site
526225009353 Switch I region; other site
526225009354 G2 box; other site
526225009355 G3 box; other site
526225009356 Switch II region; other site
526225009357 G4 box; other site
526225009358 G5 box; other site
526225009359 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
526225009360 Translation-initiation factor 2; Region: IF-2; pfam11987
526225009361 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
526225009362 NusA N-terminal domain; Region: NusA_N; pfam08529
526225009363 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
526225009364 RNA binding site [nucleotide binding]; other site
526225009365 homodimer interface [polypeptide binding]; other site
526225009366 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
526225009367 putative RNA binding cleft [nucleotide binding]; other site
526225009368 Sm and related proteins; Region: Sm_like; cl00259
526225009369 ribosome maturation protein RimP; Reviewed; Region: PRK00092
526225009370 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
526225009371 putative oligomer interface [polypeptide binding]; other site
526225009372 putative RNA binding site [nucleotide binding]; other site
526225009373 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
526225009374 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
526225009375 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
526225009376 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312
526225009377 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526225009378 Coenzyme A binding pocket [chemical binding]; other site
526225009379 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
526225009380 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
526225009381 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
526225009382 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
526225009383 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
526225009384 active site
526225009385 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
526225009386 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
526225009387 putative substrate binding region [chemical binding]; other site
526225009388 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
526225009389 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
526225009390 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
526225009391 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
526225009392 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939
526225009393 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
526225009394 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
526225009395 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
526225009396 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526225009397 FeS/SAM binding site; other site
526225009398 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
526225009399 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
526225009400 RNA polymerase factor sigma-70; Validated; Region: PRK08241
526225009401 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526225009402 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
526225009403 SnoaL-like domain; Region: SnoaL_2; pfam12680
526225009404 RibD C-terminal domain; Region: RibD_C; cl17279
526225009405 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
526225009406 Protein of unknown function (DUF952); Region: DUF952; cl01393
526225009407 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
526225009408 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
526225009409 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
526225009410 ribosome recycling factor; Reviewed; Region: frr; PRK00083
526225009411 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
526225009412 hinge region; other site
526225009413 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
526225009414 putative nucleotide binding site [chemical binding]; other site
526225009415 uridine monophosphate binding site [chemical binding]; other site
526225009416 homohexameric interface [polypeptide binding]; other site
526225009417 elongation factor Ts; Provisional; Region: tsf; PRK09377
526225009418 UBA/TS-N domain; Region: UBA; pfam00627
526225009419 Elongation factor TS; Region: EF_TS; pfam00889
526225009420 Elongation factor TS; Region: EF_TS; pfam00889
526225009421 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
526225009422 rRNA interaction site [nucleotide binding]; other site
526225009423 S8 interaction site; other site
526225009424 putative laminin-1 binding site; other site
526225009425 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
526225009426 Peptidase family M23; Region: Peptidase_M23; pfam01551
526225009427 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
526225009428 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526225009429 Sigma-70 region 3; Region: Sigma70_r3; pfam04539
526225009430 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526225009431 DNA binding residues [nucleotide binding]
526225009432 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
526225009433 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
526225009434 active site
526225009435 DNA binding site [nucleotide binding]
526225009436 Int/Topo IB signature motif; other site
526225009437 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
526225009438 DNA protecting protein DprA; Region: dprA; TIGR00732
526225009439 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
526225009440 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
526225009441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526225009442 Walker A motif; other site
526225009443 ATP binding site [chemical binding]; other site
526225009444 Walker B motif; other site
526225009445 arginine finger; other site
526225009446 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
526225009447 hypothetical protein; Reviewed; Region: PRK12497
526225009448 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
526225009449 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
526225009450 RNA/DNA hybrid binding site [nucleotide binding]; other site
526225009451 active site
526225009452 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225009453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225009454 active site
526225009455 phosphorylation site [posttranslational modification]
526225009456 intermolecular recognition site; other site
526225009457 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225009458 DNA binding residues [nucleotide binding]
526225009459 dimerization interface [polypeptide binding]; other site
526225009460 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
526225009461 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
526225009462 Catalytic site [active]
526225009463 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
526225009464 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
526225009465 nudix motif; other site
526225009466 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
526225009467 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
526225009468 RimM N-terminal domain; Region: RimM; pfam01782
526225009469 hypothetical protein; Provisional; Region: PRK02821
526225009470 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
526225009471 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
526225009472 prolyl-tRNA synthetase; Provisional; Region: PRK09194
526225009473 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
526225009474 motif 1; other site
526225009475 dimer interface [polypeptide binding]; other site
526225009476 active site
526225009477 motif 2; other site
526225009478 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
526225009479 putative deacylase active site [active]
526225009480 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
526225009481 active site
526225009482 motif 3; other site
526225009483 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
526225009484 anticodon binding site; other site
526225009485 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
526225009486 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
526225009487 active site
526225009488 signal recognition particle protein; Provisional; Region: PRK10867
526225009489 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
526225009490 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
526225009491 P loop; other site
526225009492 GTP binding site [chemical binding]; other site
526225009493 Signal peptide binding domain; Region: SRP_SPB; pfam02978
526225009494 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
526225009495 PII uridylyl-transferase; Provisional; Region: PRK03381
526225009496 metal binding triad; other site
526225009497 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
526225009498 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
526225009499 Zn2+ binding site [ion binding]; other site
526225009500 Mg2+ binding site [ion binding]; other site
526225009501 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873
526225009502 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
526225009503 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
526225009504 Nitrogen regulatory protein P-II; Region: P-II; smart00938
526225009505 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
526225009506 Cobalt transport protein; Region: CbiQ; cl00463
526225009507 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
526225009508 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
526225009509 Walker A/P-loop; other site
526225009510 ATP binding site [chemical binding]; other site
526225009511 Q-loop/lid; other site
526225009512 ABC transporter signature motif; other site
526225009513 Walker B; other site
526225009514 D-loop; other site
526225009515 H-loop/switch region; other site
526225009516 PAS fold; Region: PAS_4; pfam08448
526225009517 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
526225009518 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
526225009519 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
526225009520 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
526225009521 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
526225009522 putative active site [active]
526225009523 putative metal binding site [ion binding]; other site
526225009524 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
526225009525 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
526225009526 putative catalytic site [active]
526225009527 putative metal binding site [ion binding]; other site
526225009528 putative phosphate binding site [ion binding]; other site
526225009529 putative catalytic site [active]
526225009530 putative phosphate binding site [ion binding]; other site
526225009531 putative metal binding site [ion binding]; other site
526225009532 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
526225009533 Coenzyme A binding pocket [chemical binding]; other site
526225009534 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
526225009535 putative catalytic site [active]
526225009536 putative metal binding site [ion binding]; other site
526225009537 putative phosphate binding site [ion binding]; other site
526225009538 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
526225009539 AAA domain; Region: AAA_23; pfam13476
526225009540 Walker A/P-loop; other site
526225009541 ATP binding site [chemical binding]; other site
526225009542 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
526225009543 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
526225009544 ABC transporter signature motif; other site
526225009545 Walker B; other site
526225009546 D-loop; other site
526225009547 H-loop/switch region; other site
526225009548 Acylphosphatase; Region: Acylphosphatase; pfam00708
526225009549 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
526225009550 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
526225009551 DNA binding site [nucleotide binding]
526225009552 catalytic residue [active]
526225009553 H2TH interface [polypeptide binding]; other site
526225009554 putative catalytic residues [active]
526225009555 turnover-facilitating residue; other site
526225009556 intercalation triad [nucleotide binding]; other site
526225009557 8OG recognition residue [nucleotide binding]; other site
526225009558 putative reading head residues; other site
526225009559 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
526225009560 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
526225009561 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
526225009562 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
526225009563 dimerization interface [polypeptide binding]; other site
526225009564 active site
526225009565 metal binding site [ion binding]; metal-binding site
526225009566 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
526225009567 dsRNA binding site [nucleotide binding]; other site
526225009568 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
526225009569 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
526225009570 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
526225009571 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
526225009572 active site
526225009573 (T/H)XGH motif; other site
526225009574 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
526225009575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225009576 S-adenosylmethionine binding site [chemical binding]; other site
526225009577 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
526225009578 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
526225009579 generic binding surface II; other site
526225009580 ssDNA binding site; other site
526225009581 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526225009582 ATP binding site [chemical binding]; other site
526225009583 putative Mg++ binding site [ion binding]; other site
526225009584 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526225009585 nucleotide binding region [chemical binding]; other site
526225009586 ATP-binding site [chemical binding]; other site
526225009587 DAK2 domain; Region: Dak2; pfam02734
526225009588 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684
526225009589 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
526225009590 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
526225009591 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
526225009592 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526225009593 Coenzyme A binding pocket [chemical binding]; other site
526225009594 thiamine monophosphate kinase; Provisional; Region: PRK05731
526225009595 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
526225009596 ATP binding site [chemical binding]; other site
526225009597 dimerization interface [polypeptide binding]; other site
526225009598 Transcriptional regulators [Transcription]; Region: Lrp; COG1522
526225009599 AsnC family; Region: AsnC_trans_reg; pfam01037
526225009600 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
526225009601 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
526225009602 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
526225009603 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
526225009604 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
526225009605 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
526225009606 cystathionine gamma-lyase; Validated; Region: PRK07582
526225009607 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
526225009608 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526225009609 catalytic residue [active]
526225009610 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
526225009611 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
526225009612 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
526225009613 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
526225009614 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
526225009615 putative acyl-acceptor binding pocket; other site
526225009616 Guanylyl transferase CofC like; Region: CofC; cl17472
526225009617 polyphosphate kinase; Provisional; Region: PRK05443
526225009618 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
526225009619 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
526225009620 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
526225009621 putative domain interface [polypeptide binding]; other site
526225009622 putative active site [active]
526225009623 catalytic site [active]
526225009624 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
526225009625 putative domain interface [polypeptide binding]; other site
526225009626 putative active site [active]
526225009627 catalytic site [active]
526225009628 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
526225009629 active site
526225009630 Ap6A binding site [chemical binding]; other site
526225009631 nudix motif; other site
526225009632 metal binding site [ion binding]; metal-binding site
526225009633 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526225009634 catalytic core [active]
526225009635 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
526225009636 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
526225009637 substrate binding site [chemical binding]; other site
526225009638 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
526225009639 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
526225009640 substrate binding site [chemical binding]; other site
526225009641 ligand binding site [chemical binding]; other site
526225009642 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
526225009643 Transcriptional regulator [Transcription]; Region: IclR; COG1414
526225009644 Bacterial transcriptional regulator; Region: IclR; pfam01614
526225009645 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
526225009646 Moco binding site; other site
526225009647 metal coordination site [ion binding]; other site
526225009648 dimerization interface [polypeptide binding]; other site
526225009649 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
526225009650 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
526225009651 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
526225009652 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
526225009653 dimer interface [polypeptide binding]; other site
526225009654 active site
526225009655 CAAX protease self-immunity; Region: Abi; pfam02517
526225009656 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
526225009657 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
526225009658 HIGH motif; other site
526225009659 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
526225009660 active site
526225009661 KMSKS motif; other site
526225009662 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
526225009663 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
526225009664 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
526225009665 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
526225009666 active site
526225009667 Uncharacterized conserved protein [Function unknown]; Region: COG1359
526225009668 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
526225009669 Histidine kinase; Region: HisKA_3; pfam07730
526225009670 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225009671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225009672 active site
526225009673 phosphorylation site [posttranslational modification]
526225009674 intermolecular recognition site; other site
526225009675 dimerization interface [polypeptide binding]; other site
526225009676 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225009677 DNA binding residues [nucleotide binding]
526225009678 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
526225009679 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
526225009680 active site
526225009681 catalytic residues [active]
526225009682 metal binding site [ion binding]; metal-binding site
526225009683 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
526225009684 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
526225009685 tartrate dehydrogenase; Region: TTC; TIGR02089
526225009686 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
526225009687 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
526225009688 ligand binding site [chemical binding]; other site
526225009689 NAD binding site [chemical binding]; other site
526225009690 dimerization interface [polypeptide binding]; other site
526225009691 catalytic site [active]
526225009692 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
526225009693 putative L-serine binding site [chemical binding]; other site
526225009694 ketol-acid reductoisomerase; Provisional; Region: PRK05479
526225009695 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
526225009696 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
526225009697 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
526225009698 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
526225009699 putative valine binding site [chemical binding]; other site
526225009700 dimer interface [polypeptide binding]; other site
526225009701 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
526225009702 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
526225009703 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
526225009704 PYR/PP interface [polypeptide binding]; other site
526225009705 dimer interface [polypeptide binding]; other site
526225009706 TPP binding site [chemical binding]; other site
526225009707 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
526225009708 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
526225009709 TPP-binding site [chemical binding]; other site
526225009710 dimer interface [polypeptide binding]; other site
526225009711 PAS domain S-box; Region: sensory_box; TIGR00229
526225009712 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
526225009713 putative active site [active]
526225009714 heme pocket [chemical binding]; other site
526225009715 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199
526225009716 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
526225009717 metal binding site [ion binding]; metal-binding site
526225009718 active site
526225009719 I-site; other site
526225009720 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
526225009721 PAS domain S-box; Region: sensory_box; TIGR00229
526225009722 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
526225009723 putative active site [active]
526225009724 heme pocket [chemical binding]; other site
526225009725 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
526225009726 metal binding site [ion binding]; metal-binding site
526225009727 active site
526225009728 I-site; other site
526225009729 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
526225009730 dihydroxy-acid dehydratase; Provisional; Region: PRK00911
526225009731 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526225009732 salt bridge; other site
526225009733 non-specific DNA binding site [nucleotide binding]; other site
526225009734 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526225009735 sequence-specific DNA binding site [nucleotide binding]; other site
526225009736 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
526225009737 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166
526225009738 putative ligand binding site [chemical binding]; other site
526225009739 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
526225009740 putative NAD binding site [chemical binding]; other site
526225009741 catalytic site [active]
526225009742 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
526225009743 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
526225009744 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
526225009745 GatB/GatE catalytic domain; Region: GatB_N; pfam02934
526225009746 GatB domain; Region: GatB_Yqey; smart00845
526225009747 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
526225009748 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
526225009749 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
526225009750 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
526225009751 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
526225009752 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
526225009753 nucleotide binding pocket [chemical binding]; other site
526225009754 K-X-D-G motif; other site
526225009755 catalytic site [active]
526225009756 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
526225009757 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
526225009758 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
526225009759 Dimer interface [polypeptide binding]; other site
526225009760 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310
526225009761 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
526225009762 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
526225009763 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
526225009764 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
526225009765 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526225009766 catalytic residue [active]
526225009767 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
526225009768 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
526225009769 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
526225009770 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
526225009771 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
526225009772 Ligand binding site [chemical binding]; other site
526225009773 Electron transfer flavoprotein domain; Region: ETF; pfam01012
526225009774 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
526225009775 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526225009776 substrate binding site [chemical binding]; other site
526225009777 oxyanion hole (OAH) forming residues; other site
526225009778 trimer interface [polypeptide binding]; other site
526225009779 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
526225009780 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
526225009781 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225009782 Walker A/P-loop; other site
526225009783 ATP binding site [chemical binding]; other site
526225009784 Q-loop/lid; other site
526225009785 ABC transporter signature motif; other site
526225009786 Walker B; other site
526225009787 D-loop; other site
526225009788 H-loop/switch region; other site
526225009789 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
526225009790 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
526225009791 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
526225009792 active site
526225009793 catalytic site [active]
526225009794 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
526225009795 phosphopeptide binding site; other site
526225009796 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
526225009797 putative homodimer interface [polypeptide binding]; other site
526225009798 putative active site pocket [active]
526225009799 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
526225009800 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
526225009801 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
526225009802 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
526225009803 active site
526225009804 homodimer interface [polypeptide binding]; other site
526225009805 catalytic site [active]
526225009806 acceptor binding site [chemical binding]; other site
526225009807 trehalose synthase; Region: treS_nterm; TIGR02456
526225009808 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
526225009809 active site
526225009810 catalytic site [active]
526225009811 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
526225009812 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
526225009813 MARCKS family; Region: MARCKS; pfam02063
526225009814 glycogen branching enzyme; Provisional; Region: PRK05402
526225009815 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
526225009816 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
526225009817 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
526225009818 active site
526225009819 catalytic site [active]
526225009820 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
526225009821 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
526225009822 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
526225009823 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
526225009824 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526225009825 MarR family; Region: MarR; pfam01047
526225009826 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
526225009827 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526225009828 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
526225009829 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
526225009830 Walker A; other site
526225009831 putative acyltransferase; Provisional; Region: PRK05790
526225009832 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
526225009833 dimer interface [polypeptide binding]; other site
526225009834 active site
526225009835 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526225009836 TAP-like protein; Region: Abhydrolase_4; pfam08386
526225009837 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526225009838 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
526225009839 dimer interface [polypeptide binding]; other site
526225009840 substrate binding site [chemical binding]; other site
526225009841 metal binding site [ion binding]; metal-binding site
526225009842 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
526225009843 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751
526225009844 NAD(P) binding site [chemical binding]; other site
526225009845 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
526225009846 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829
526225009847 active site
526225009848 putative catalytic site [active]
526225009849 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
526225009850 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
526225009851 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
526225009852 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
526225009853 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
526225009854 hypothetical protein; Provisional; Region: PRK03298
526225009855 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637
526225009856 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
526225009857 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
526225009858 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
526225009859 putative active site [active]
526225009860 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
526225009861 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526225009862 enoyl-CoA hydratase; Validated; Region: PRK08139
526225009863 substrate binding site [chemical binding]; other site
526225009864 oxyanion hole (OAH) forming residues; other site
526225009865 trimer interface [polypeptide binding]; other site
526225009866 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844
526225009867 putative oxidoreductase; Provisional; Region: PRK11579
526225009868 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526225009869 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
526225009870 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
526225009871 B12 binding site [chemical binding]; other site
526225009872 cyclase homology domain; Region: CHD; cd07302
526225009873 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
526225009874 nucleotidyl binding site; other site
526225009875 metal binding site [ion binding]; metal-binding site
526225009876 dimer interface [polypeptide binding]; other site
526225009877 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
526225009878 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
526225009879 hinge; other site
526225009880 active site
526225009881 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096
526225009882 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
526225009883 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
526225009884 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
526225009885 gamma subunit interface [polypeptide binding]; other site
526225009886 epsilon subunit interface [polypeptide binding]; other site
526225009887 LBP interface [polypeptide binding]; other site
526225009888 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
526225009889 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
526225009890 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
526225009891 alpha subunit interaction interface [polypeptide binding]; other site
526225009892 Walker A motif; other site
526225009893 ATP binding site [chemical binding]; other site
526225009894 Walker B motif; other site
526225009895 inhibitor binding site; inhibition site
526225009896 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
526225009897 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
526225009898 core domain interface [polypeptide binding]; other site
526225009899 delta subunit interface [polypeptide binding]; other site
526225009900 epsilon subunit interface [polypeptide binding]; other site
526225009901 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
526225009902 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
526225009903 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
526225009904 beta subunit interaction interface [polypeptide binding]; other site
526225009905 Walker A motif; other site
526225009906 ATP binding site [chemical binding]; other site
526225009907 Walker B motif; other site
526225009908 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
526225009909 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
526225009910 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
526225009911 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
526225009912 F0F1 ATP synthase subunit B; Validated; Region: PRK05759
526225009913 ATP synthase subunit C; Region: ATP-synt_C; cl00466
526225009914 F0F1 ATP synthase subunit A; Validated; Region: PRK05815
526225009915 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
526225009916 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
526225009917 Mg++ binding site [ion binding]; other site
526225009918 putative catalytic motif [active]
526225009919 substrate binding site [chemical binding]; other site
526225009920 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
526225009921 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
526225009922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225009923 S-adenosylmethionine binding site [chemical binding]; other site
526225009924 peptide chain release factor 1; Validated; Region: prfA; PRK00591
526225009925 This domain is found in peptide chain release factors; Region: PCRF; smart00937
526225009926 RF-1 domain; Region: RF-1; pfam00472
526225009927 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
526225009928 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
526225009929 transcription termination factor Rho; Provisional; Region: PRK12608
526225009930 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
526225009931 RNA binding site [nucleotide binding]; other site
526225009932 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
526225009933 multimer interface [polypeptide binding]; other site
526225009934 Walker A motif; other site
526225009935 ATP binding site [chemical binding]; other site
526225009936 Walker B motif; other site
526225009937 homoserine kinase; Provisional; Region: PRK01212
526225009938 threonine synthase; Reviewed; Region: PRK06721
526225009939 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
526225009940 homodimer interface [polypeptide binding]; other site
526225009941 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225009942 catalytic residue [active]
526225009943 homoserine dehydrogenase; Provisional; Region: PRK06349
526225009944 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
526225009945 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
526225009946 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
526225009947 diaminopimelate decarboxylase; Region: lysA; TIGR01048
526225009948 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
526225009949 active site
526225009950 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
526225009951 substrate binding site [chemical binding]; other site
526225009952 catalytic residues [active]
526225009953 dimer interface [polypeptide binding]; other site
526225009954 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
526225009955 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
526225009956 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
526225009957 active site
526225009958 HIGH motif; other site
526225009959 KMSK motif region; other site
526225009960 tRNA binding surface [nucleotide binding]; other site
526225009961 DALR anticodon binding domain; Region: DALR_1; smart00836
526225009962 anticodon binding site; other site
526225009963 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303
526225009964 Domain of unknown function (DUF305); Region: DUF305; pfam03713
526225009965 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225009966 NmrA-like family; Region: NmrA; pfam05368
526225009967 NAD(P) binding site [chemical binding]; other site
526225009968 active site
526225009969 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
526225009970 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225009971 NAD(P) binding site [chemical binding]; other site
526225009972 active site
526225009973 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
526225009974 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
526225009975 acyl-activating enzyme (AAE) consensus motif; other site
526225009976 putative AMP binding site [chemical binding]; other site
526225009977 putative active site [active]
526225009978 putative CoA binding site [chemical binding]; other site
526225009979 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836
526225009980 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
526225009981 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
526225009982 Acetyltransferases [General function prediction only]; Region: RimI; COG0456
526225009983 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526225009984 Coenzyme A binding pocket [chemical binding]; other site
526225009985 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
526225009986 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526225009987 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526225009988 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526225009989 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
526225009990 cyclase homology domain; Region: CHD; cd07302
526225009991 nucleotidyl binding site; other site
526225009992 metal binding site [ion binding]; metal-binding site
526225009993 dimer interface [polypeptide binding]; other site
526225009994 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
526225009995 Ligand Binding Site [chemical binding]; other site
526225009996 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
526225009997 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
526225009998 Walker A/P-loop; other site
526225009999 ATP binding site [chemical binding]; other site
526225010000 Q-loop/lid; other site
526225010001 ABC transporter signature motif; other site
526225010002 Walker B; other site
526225010003 D-loop; other site
526225010004 H-loop/switch region; other site
526225010005 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
526225010006 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
526225010007 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
526225010008 Ankyrin repeats (many copies); Region: Ank_5; pfam13857
526225010009 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
526225010010 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
526225010011 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
526225010012 TPP-binding site [chemical binding]; other site
526225010013 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
526225010014 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
526225010015 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
526225010016 Malic enzyme, N-terminal domain; Region: malic; pfam00390
526225010017 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919
526225010018 NAD(P) binding pocket [chemical binding]; other site
526225010019 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
526225010020 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
526225010021 Catalytic site [active]
526225010022 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055
526225010023 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526225010024 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
526225010025 dimer interface [polypeptide binding]; other site
526225010026 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
526225010027 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
526225010028 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
526225010029 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526225010030 Coenzyme A binding pocket [chemical binding]; other site
526225010031 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526225010032 UMP phosphatase; Provisional; Region: PRK10444
526225010033 active site
526225010034 motif I; other site
526225010035 motif II; other site
526225010036 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526225010037 motif II; other site
526225010038 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
526225010039 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
526225010040 Transcription factor WhiB; Region: Whib; pfam02467
526225010041 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
526225010042 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
526225010043 Histidine kinase; Region: HisKA_2; pfam07568
526225010044 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526225010045 Coenzyme A binding pocket [chemical binding]; other site
526225010046 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
526225010047 carboxyltransferase (CT) interaction site; other site
526225010048 biotinylation site [posttranslational modification]; other site
526225010049 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
526225010050 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988
526225010051 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
526225010052 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526225010053 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526225010054 DNA binding residues [nucleotide binding]
526225010055 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
526225010056 putative deacylase active site [active]
526225010057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
526225010058 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
526225010059 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
526225010060 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
526225010061 NAD(P) binding site [chemical binding]; other site
526225010062 catalytic residues [active]
526225010063 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
526225010064 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
526225010065 hinge; other site
526225010066 active site
526225010067 Predicted GTPases [General function prediction only]; Region: COG1162
526225010068 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
526225010069 GTPase/Zn-binding domain interface [polypeptide binding]; other site
526225010070 GTP/Mg2+ binding site [chemical binding]; other site
526225010071 G4 box; other site
526225010072 G5 box; other site
526225010073 G1 box; other site
526225010074 Switch I region; other site
526225010075 G2 box; other site
526225010076 G3 box; other site
526225010077 Switch II region; other site
526225010078 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
526225010079 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
526225010080 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
526225010081 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
526225010082 active site
526225010083 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
526225010084 nucleotide binding site [chemical binding]; other site
526225010085 XdhC Rossmann domain; Region: XdhC_C; pfam13478
526225010086 short chain dehydrogenase; Validated; Region: PRK05855
526225010087 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526225010088 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526225010089 active site
526225010090 catalytic tetrad [active]
526225010091 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
526225010092 Cytochrome P450; Region: p450; cl12078
526225010093 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526225010094 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526225010095 active site
526225010096 catalytic tetrad [active]
526225010097 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526225010098 cystathionine beta-synthase; Region: cysta_beta; TIGR01137
526225010099 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
526225010100 dimer interface [polypeptide binding]; other site
526225010101 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225010102 catalytic residue [active]
526225010103 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
526225010104 cystathionine gamma-synthase; Provisional; Region: PRK07811
526225010105 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
526225010106 homodimer interface [polypeptide binding]; other site
526225010107 substrate-cofactor binding pocket; other site
526225010108 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225010109 catalytic residue [active]
526225010110 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
526225010111 active site
526225010112 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
526225010113 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
526225010114 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526225010115 Zn binding site [ion binding]; other site
526225010116 Predicted acetyltransferase [General function prediction only]; Region: COG2388
526225010117 glycine betaine transporter membrane protein; Provisional; Region: PRK10952
526225010118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526225010119 dimer interface [polypeptide binding]; other site
526225010120 conserved gate region; other site
526225010121 ABC-ATPase subunit interface; other site
526225010122 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
526225010123 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
526225010124 Walker A/P-loop; other site
526225010125 ATP binding site [chemical binding]; other site
526225010126 Q-loop/lid; other site
526225010127 ABC transporter signature motif; other site
526225010128 Walker B; other site
526225010129 D-loop; other site
526225010130 H-loop/switch region; other site
526225010131 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
526225010132 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
526225010133 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
526225010134 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
526225010135 active site
526225010136 iron coordination sites [ion binding]; other site
526225010137 substrate binding pocket [chemical binding]; other site
526225010138 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526225010139 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225010140 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329
526225010141 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
526225010142 hypothetical protein; Validated; Region: PRK00068
526225010143 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
526225010144 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
526225010145 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
526225010146 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
526225010147 Protein of unknown function DUF45; Region: DUF45; pfam01863
526225010148 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
526225010149 ABC1 family; Region: ABC1; pfam03109
526225010150 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
526225010151 active site
526225010152 ATP binding site [chemical binding]; other site
526225010153 Transcription factor WhiB; Region: Whib; pfam02467
526225010154 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
526225010155 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
526225010156 Part of AAA domain; Region: AAA_19; pfam13245
526225010157 Family description; Region: UvrD_C_2; pfam13538
526225010158 HRDC domain; Region: HRDC; pfam00570
526225010159 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
526225010160 catalytic residues [active]
526225010161 ANTAR domain; Region: ANTAR; pfam03861
526225010162 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
526225010163 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
526225010164 putative NADH binding site [chemical binding]; other site
526225010165 putative active site [active]
526225010166 nudix motif; other site
526225010167 putative metal binding site [ion binding]; other site
526225010168 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
526225010169 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
526225010170 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
526225010171 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
526225010172 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
526225010173 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
526225010174 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526225010175 Catalytic domain of Protein Kinases; Region: PKc; cd00180
526225010176 active site
526225010177 ATP binding site [chemical binding]; other site
526225010178 substrate binding site [chemical binding]; other site
526225010179 activation loop (A-loop); other site
526225010180 hypothetical protein; Provisional; Region: PRK08201
526225010181 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
526225010182 metal binding site [ion binding]; metal-binding site
526225010183 putative dimer interface [polypeptide binding]; other site
526225010184 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526225010185 Putative lysophospholipase; Region: Hydrolase_4; pfam12146
526225010186 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
526225010187 Part of AAA domain; Region: AAA_19; pfam13245
526225010188 Family description; Region: UvrD_C_2; pfam13538
526225010189 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
526225010190 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
526225010191 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
526225010192 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
526225010193 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cl01497
526225010194 active site
526225010195 DNA binding site [nucleotide binding]
526225010196 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
526225010197 TIGR03086 family protein; Region: TIGR03086
526225010198 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
526225010199 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
526225010200 ATP binding site [chemical binding]; other site
526225010201 substrate interface [chemical binding]; other site
526225010202 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
526225010203 active site residue [active]
526225010204 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350
526225010205 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
526225010206 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
526225010207 catalytic site [active]
526225010208 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526225010209 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225010210 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
526225010211 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
526225010212 dinuclear metal binding motif [ion binding]; other site
526225010213 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268
526225010214 DEAD-like helicases superfamily; Region: DEXDc; smart00487
526225010215 ATP binding site [chemical binding]; other site
526225010216 Mg++ binding site [ion binding]; other site
526225010217 motif III; other site
526225010218 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526225010219 nucleotide binding region [chemical binding]; other site
526225010220 ATP-binding site [chemical binding]; other site
526225010221 PQQ-like domain; Region: PQQ_2; pfam13360
526225010222 Putative lysophospholipase; Region: Hydrolase_4; pfam12146
526225010223 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526225010224 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
526225010225 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
526225010226 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
526225010227 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
526225010228 active site
526225010229 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
526225010230 Bacterial PH domain; Region: DUF304; pfam03703
526225010231 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
526225010232 nudix motif; other site
526225010233 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
526225010234 putative active site [active]
526225010235 putative catalytic site [active]
526225010236 Proteins of 100 residues with WXG; Region: WXG100; cl02005
526225010237 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
526225010238 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
526225010239 phosphopeptide binding site; other site
526225010240 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
526225010241 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
526225010242 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
526225010243 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
526225010244 AAA domain; Region: AAA_31; pfam13614
526225010245 Helix-turn-helix domain; Region: HTH_17; pfam12728
526225010246 preprotein translocase subunit SecA; Reviewed; Region: PRK12904
526225010247 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
526225010248 ATP binding site [chemical binding]; other site
526225010249 putative Mg++ binding site [ion binding]; other site
526225010250 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
526225010251 SEC-C motif; Region: SEC-C; pfam02810
526225010252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225010253 active site
526225010254 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
526225010255 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
526225010256 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
526225010257 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
526225010258 30S subunit binding site; other site
526225010259 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
526225010260 lipoprotein LpqB; Provisional; Region: PRK13613
526225010261 Sporulation and spore germination; Region: Germane; pfam10646
526225010262 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
526225010263 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
526225010264 dimerization interface [polypeptide binding]; other site
526225010265 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
526225010266 dimer interface [polypeptide binding]; other site
526225010267 phosphorylation site [posttranslational modification]
526225010268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225010269 ATP binding site [chemical binding]; other site
526225010270 Mg2+ binding site [ion binding]; other site
526225010271 G-X-G motif; other site
526225010272 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526225010273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225010274 active site
526225010275 phosphorylation site [posttranslational modification]
526225010276 intermolecular recognition site; other site
526225010277 dimerization interface [polypeptide binding]; other site
526225010278 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526225010279 DNA binding site [nucleotide binding]
526225010280 Adenosylhomocysteinase; Provisional; Region: PTZ00075
526225010281 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
526225010282 homotetramer interface [polypeptide binding]; other site
526225010283 ligand binding site [chemical binding]; other site
526225010284 catalytic site [active]
526225010285 NAD binding site [chemical binding]; other site
526225010286 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
526225010287 Excalibur calcium-binding domain; Region: Excalibur; smart00894
526225010288 Methyltransferase domain; Region: Methyltransf_24; pfam13578
526225010289 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132
526225010290 putative CoA binding site [chemical binding]; other site
526225010291 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
526225010292 putative trimer interface [polypeptide binding]; other site
526225010293 putative active site [active]
526225010294 putative substrate binding site [chemical binding]; other site
526225010295 putative CoA binding site [chemical binding]; other site
526225010296 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
526225010297 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
526225010298 inhibitor-cofactor binding pocket; inhibition site
526225010299 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225010300 catalytic residue [active]
526225010301 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526225010302 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526225010303 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526225010304 active site
526225010305 Bacterial membrane protein YfhO; Region: YfhO; pfam09586
526225010306 mannose-6-phosphate isomerase; Provisional; Region: PRK15131
526225010307 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
526225010308 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
526225010309 Bacterial phospho-glucose isomerase C-terminal region; Region: bact-PGI_C; pfam10432
526225010310 Uncharacterized conserved protein [Function unknown]; Region: COG2835
526225010311 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
526225010312 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
526225010313 active site
526225010314 substrate binding site [chemical binding]; other site
526225010315 metal binding site [ion binding]; metal-binding site
526225010316 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
526225010317 Minimal MMP-like domain found in Thermus thermophilus TTHA0227, Acidothermus cellulolyticus ACEL2062 and similar proteins; Region: MMP_TTHA0227_like; cl01577
526225010318 Transcription factor WhiB; Region: Whib; pfam02467
526225010319 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606
526225010320 dimer interface [polypeptide binding]; other site
526225010321 phosphate binding site [ion binding]; other site
526225010322 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478
526225010323 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
526225010324 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
526225010325 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
526225010326 substrate binding site; other site
526225010327 tetramer interface; other site
526225010328 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526225010329 active site
526225010330 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
526225010331 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
526225010332 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225010333 NAD(P) binding site [chemical binding]; other site
526225010334 active site
526225010335 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
526225010336 FAD dependent oxidoreductase; Region: DAO; pfam01266
526225010337 hydroxyglutarate oxidase; Provisional; Region: PRK11728
526225010338 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
526225010339 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
526225010340 helix-hairpin-helix signature motif; other site
526225010341 active site
526225010342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225010343 NAD(P) binding site [chemical binding]; other site
526225010344 active site
526225010345 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526225010346 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
526225010347 active site
526225010348 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
526225010349 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
526225010350 Probable Catalytic site; other site
526225010351 metal-binding site
526225010352 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
526225010353 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526225010354 UDP-galactopyranose mutase; Region: GLF; pfam03275
526225010355 Predicted glycosyltransferases [General function prediction only]; Region: COG1216
526225010356 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526225010357 Predicted glycosyltransferases [General function prediction only]; Region: COG1216
526225010358 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526225010359 active site
526225010360 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
526225010361 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
526225010362 Walker A/P-loop; other site
526225010363 ATP binding site [chemical binding]; other site
526225010364 Q-loop/lid; other site
526225010365 ABC transporter signature motif; other site
526225010366 Walker B; other site
526225010367 D-loop; other site
526225010368 H-loop/switch region; other site
526225010369 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
526225010370 ABC-2 type transporter; Region: ABC2_membrane; pfam01061
526225010371 Predicted glycosyltransferases [General function prediction only]; Region: COG1216
526225010372 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526225010373 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526225010374 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
526225010375 LGFP repeat; Region: LGFP; pfam08310
526225010376 LGFP repeat; Region: LGFP; pfam08310
526225010377 LGFP repeat; Region: LGFP; pfam08310
526225010378 LGFP repeat; Region: LGFP; pfam08310
526225010379 LGFP repeat; Region: LGFP; pfam08310
526225010380 LGFP repeat; Region: LGFP; pfam08310
526225010381 LGFP repeat; Region: LGFP; pfam08310
526225010382 LGFP repeat; Region: LGFP; pfam08310
526225010383 LGFP repeat; Region: LGFP; pfam08310
526225010384 LGFP repeat; Region: LGFP; pfam08310
526225010385 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
526225010386 amidase catalytic site [active]
526225010387 Zn binding residues [ion binding]; other site
526225010388 substrate binding site [chemical binding]; other site
526225010389 LGFP repeat; Region: LGFP; pfam08310
526225010390 LGFP repeat; Region: LGFP; pfam08310
526225010391 LGFP repeat; Region: LGFP; pfam08310
526225010392 LGFP repeat; Region: LGFP; pfam08310
526225010393 LGFP repeat; Region: LGFP; pfam08310
526225010394 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
526225010395 LGFP repeat; Region: LGFP; pfam08310
526225010396 LGFP repeat; Region: LGFP; pfam08310
526225010397 LGFP repeat; Region: LGFP; pfam08310
526225010398 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
526225010399 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225010400 NAD(P) binding site [chemical binding]; other site
526225010401 active site
526225010402 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
526225010403 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
526225010404 NAD binding site [chemical binding]; other site
526225010405 substrate binding site [chemical binding]; other site
526225010406 homodimer interface [polypeptide binding]; other site
526225010407 active site
526225010408 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
526225010409 ligand binding site; other site
526225010410 tetramer interface; other site
526225010411 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
526225010412 active site
526225010413 homodimer interface [polypeptide binding]; other site
526225010414 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
526225010415 NeuB family; Region: NeuB; pfam03102
526225010416 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
526225010417 NeuB binding interface [polypeptide binding]; other site
526225010418 putative substrate binding site [chemical binding]; other site
526225010419 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
526225010420 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
526225010421 TIGR03089 family protein; Region: TIGR03089
526225010422 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
526225010423 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
526225010424 Family of unknown function (DUF1028); Region: DUF1028; pfam06267
526225010425 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
526225010426 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
526225010427 Predicted membrane protein [Function unknown]; Region: COG2323
526225010428 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
526225010429 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422
526225010430 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
526225010431 DNA binding residues [nucleotide binding]
526225010432 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
526225010433 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
526225010434 Sulfate transporter family; Region: Sulfate_transp; pfam00916
526225010435 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
526225010436 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526225010437 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526225010438 active site
526225010439 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
526225010440 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
526225010441 ATP-grasp domain; Region: ATP-grasp_4; cl17255
526225010442 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
526225010443 active site
526225010444 catalytic triad [active]
526225010445 oxyanion hole [active]
526225010446 Acyltransferase family; Region: Acyl_transf_3; pfam01757
526225010447 GtrA-like protein; Region: GtrA; pfam04138
526225010448 Predicted acyltransferases [Lipid metabolism]; Region: COG1835
526225010449 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
526225010450 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225010451 Walker A/P-loop; other site
526225010452 ATP binding site [chemical binding]; other site
526225010453 Q-loop/lid; other site
526225010454 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
526225010455 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
526225010456 ABC transporter signature motif; other site
526225010457 Walker B; other site
526225010458 D-loop; other site
526225010459 H-loop/switch region; other site
526225010460 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
526225010461 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
526225010462 active site
526225010463 metal binding site [ion binding]; metal-binding site
526225010464 DNA binding site [nucleotide binding]
526225010465 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
526225010466 Bacterial PH domain; Region: DUF304; pfam03703
526225010467 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
526225010468 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
526225010469 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
526225010470 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
526225010471 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
526225010472 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
526225010473 Maf-like protein; Region: Maf; pfam02545
526225010474 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
526225010475 active site
526225010476 dimer interface [polypeptide binding]; other site
526225010477 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
526225010478 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
526225010479 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
526225010480 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
526225010481 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
526225010482 carboxyltransferase (CT) interaction site; other site
526225010483 biotinylation site [posttranslational modification]; other site
526225010484 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
526225010485 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
526225010486 LGFP repeat; Region: LGFP; pfam08310
526225010487 LGFP repeat; Region: LGFP; pfam08310
526225010488 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
526225010489 LGFP repeat; Region: LGFP; pfam08310
526225010490 LGFP repeat; Region: LGFP; pfam08310
526225010491 LGFP repeat; Region: LGFP; pfam08310
526225010492 LGFP repeat; Region: LGFP; pfam08310
526225010493 LGFP repeat; Region: LGFP; pfam08310
526225010494 LGFP repeat; Region: LGFP; pfam08310
526225010495 LGFP repeat; Region: LGFP; pfam08310
526225010496 LGFP repeat; Region: LGFP; pfam08310
526225010497 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
526225010498 active site
526225010499 flavoprotein disulfide reductase; Reviewed; Region: PRK07845
526225010500 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
526225010501 NAD binding site [chemical binding]; other site
526225010502 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526225010503 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
526225010504 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
526225010505 putative active site pocket [active]
526225010506 dimerization interface [polypeptide binding]; other site
526225010507 putative catalytic residue [active]
526225010508 membrane ATPase/protein kinase; Provisional; Region: PRK09435
526225010509 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
526225010510 Walker A; other site
526225010511 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
526225010512 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
526225010513 active site
526225010514 substrate binding site [chemical binding]; other site
526225010515 coenzyme B12 binding site [chemical binding]; other site
526225010516 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
526225010517 B12 binding site [chemical binding]; other site
526225010518 cobalt ligand [ion binding]; other site
526225010519 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
526225010520 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
526225010521 heterodimer interface [polypeptide binding]; other site
526225010522 substrate interaction site [chemical binding]; other site
526225010523 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
526225010524 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
526225010525 metal binding site [ion binding]; metal-binding site
526225010526 putative dimer interface [polypeptide binding]; other site
526225010527 carboxylate-amine ligase; Provisional; Region: PRK13517
526225010528 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
526225010529 purine nucleoside phosphorylase; Provisional; Region: PRK08202
526225010530 extended (e) SDRs; Region: SDR_e; cd08946
526225010531 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
526225010532 NAD(P) binding site [chemical binding]; other site
526225010533 active site
526225010534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225010535 substrate binding site [chemical binding]; other site
526225010536 active site
526225010537 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
526225010538 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
526225010539 active site
526225010540 substrate binding site [chemical binding]; other site
526225010541 metal binding site [ion binding]; metal-binding site
526225010542 Predicted acyltransferases [Lipid metabolism]; Region: COG1835
526225010543 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
526225010544 intersubunit interface [polypeptide binding]; other site
526225010545 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
526225010546 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526225010547 motif II; other site
526225010548 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526225010549 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526225010550 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
526225010551 active site
526225010552 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526225010553 Coenzyme A binding pocket [chemical binding]; other site
526225010554 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
526225010555 intersubunit interface [polypeptide binding]; other site
526225010556 active site
526225010557 catalytic residue [active]
526225010558 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111
526225010559 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
526225010560 NAD(P) binding site [chemical binding]; other site
526225010561 catalytic residues [active]
526225010562 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
526225010563 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
526225010564 NAD(P) binding site [chemical binding]; other site
526225010565 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268
526225010566 DEAD-like helicases superfamily; Region: DEXDc; smart00487
526225010567 ATP binding site [chemical binding]; other site
526225010568 Mg++ binding site [ion binding]; other site
526225010569 motif III; other site
526225010570 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526225010571 nucleotide binding region [chemical binding]; other site
526225010572 ATP-binding site [chemical binding]; other site
526225010573 adenosine deaminase; Provisional; Region: PRK09358
526225010574 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
526225010575 active site
526225010576 ABC-2 type transporter; Region: ABC2_membrane; pfam01061
526225010577 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
526225010578 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
526225010579 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
526225010580 Walker A/P-loop; other site
526225010581 ATP binding site [chemical binding]; other site
526225010582 Q-loop/lid; other site
526225010583 ABC transporter signature motif; other site
526225010584 Walker B; other site
526225010585 D-loop; other site
526225010586 H-loop/switch region; other site
526225010587 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
526225010588 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
526225010589 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
526225010590 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
526225010591 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
526225010592 active site
526225010593 catalytic motif [active]
526225010594 Zn binding site [ion binding]; other site
526225010595 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
526225010596 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526225010597 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
526225010598 TM-ABC transporter signature motif; other site
526225010599 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
526225010600 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526225010601 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
526225010602 TM-ABC transporter signature motif; other site
526225010603 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
526225010604 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
526225010605 Walker A/P-loop; other site
526225010606 ATP binding site [chemical binding]; other site
526225010607 Q-loop/lid; other site
526225010608 ABC transporter signature motif; other site
526225010609 Walker B; other site
526225010610 D-loop; other site
526225010611 H-loop/switch region; other site
526225010612 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
526225010613 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
526225010614 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
526225010615 ligand binding site [chemical binding]; other site
526225010616 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
526225010617 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
526225010618 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
526225010619 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
526225010620 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
526225010621 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
526225010622 active site
526225010623 HIGH motif; other site
526225010624 dimer interface [polypeptide binding]; other site
526225010625 KMSKS motif; other site
526225010626 histidinol-phosphate aminotransferase; Validated; Region: PRK02731
526225010627 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
526225010628 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225010629 homodimer interface [polypeptide binding]; other site
526225010630 catalytic residue [active]
526225010631 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
526225010632 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
526225010633 NAD binding site [chemical binding]; other site
526225010634 homodimer interface [polypeptide binding]; other site
526225010635 active site
526225010636 substrate binding site [chemical binding]; other site
526225010637 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
526225010638 Domain of unknown function DUF21; Region: DUF21; pfam01595
526225010639 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
526225010640 Transporter associated domain; Region: CorC_HlyC; smart01091
526225010641 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
526225010642 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
526225010643 isocitrate dehydrogenase; Validated; Region: PRK08299
526225010644 malate dehydrogenase; Reviewed; Region: PRK06223
526225010645 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
526225010646 NAD(P) binding site [chemical binding]; other site
526225010647 dimer interface [polypeptide binding]; other site
526225010648 tetramer (dimer of dimers) interface [polypeptide binding]; other site
526225010649 substrate binding site [chemical binding]; other site
526225010650 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
526225010651 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
526225010652 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain; Region: THF_DHG_CYH_C; pfam02882
526225010653 NAD(P) binding pocket [chemical binding]; other site
526225010654 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
526225010655 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
526225010656 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
526225010657 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
526225010658 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421
526225010659 purine monophosphate binding site [chemical binding]; other site
526225010660 dimer interface [polypeptide binding]; other site
526225010661 putative catalytic residues [active]
526225010662 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
526225010663 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
526225010664 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
526225010665 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
526225010666 active site
526225010667 substrate binding site [chemical binding]; other site
526225010668 cosubstrate binding site; other site
526225010669 catalytic site [active]
526225010670 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
526225010671 CoA binding domain; Region: CoA_binding; smart00881
526225010672 CoA-ligase; Region: Ligase_CoA; pfam00549
526225010673 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
526225010674 ATP-grasp domain; Region: ATP-grasp_2; pfam08442
526225010675 CoA-ligase; Region: Ligase_CoA; pfam00549
526225010676 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
526225010677 B12 binding site [chemical binding]; other site
526225010678 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526225010679 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
526225010680 PGAP1-like protein; Region: PGAP1; pfam07819
526225010681 nucleophilic elbow; other site
526225010682 catalytic triad; other site
526225010683 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
526225010684 Peptidase family M23; Region: Peptidase_M23; pfam01551
526225010685 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
526225010686 Part of AAA domain; Region: AAA_19; pfam13245
526225010687 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357
526225010688 Family description; Region: UvrD_C_2; pfam13538
526225010689 Chorismate mutase type II; Region: CM_2; cl00693
526225010690 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
526225010691 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
526225010692 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225010693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225010694 active site
526225010695 phosphorylation site [posttranslational modification]
526225010696 intermolecular recognition site; other site
526225010697 dimerization interface [polypeptide binding]; other site
526225010698 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225010699 DNA binding residues [nucleotide binding]
526225010700 dimerization interface [polypeptide binding]; other site
526225010701 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
526225010702 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225010703 ATP binding site [chemical binding]; other site
526225010704 Mg2+ binding site [ion binding]; other site
526225010705 G-X-G motif; other site
526225010706 PspC domain; Region: PspC; pfam04024
526225010707 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
526225010708 glutamate dehydrogenase; Provisional; Region: PRK09414
526225010709 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
526225010710 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
526225010711 NAD(P) binding site [chemical binding]; other site
526225010712 Acetyltransferases [General function prediction only]; Region: RimI; COG0456
526225010713 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526225010714 Coenzyme A binding pocket [chemical binding]; other site
526225010715 GMP synthase; Reviewed; Region: guaA; PRK00074
526225010716 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
526225010717 AMP/PPi binding site [chemical binding]; other site
526225010718 candidate oxyanion hole; other site
526225010719 catalytic triad [active]
526225010720 potential glutamine specificity residues [chemical binding]; other site
526225010721 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
526225010722 ATP Binding subdomain [chemical binding]; other site
526225010723 Ligand Binding sites [chemical binding]; other site
526225010724 Dimerization subdomain; other site
526225010725 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
526225010726 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
526225010727 phosphate binding site [ion binding]; other site
526225010728 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
526225010729 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
526225010730 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
526225010731 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
526225010732 active site
526225010733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225010734 active site
526225010735 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225010736 phosphorylation site [posttranslational modification]
526225010737 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225010738 DNA binding residues [nucleotide binding]
526225010739 dimerization interface [polypeptide binding]; other site
526225010740 Transcription factor WhiB; Region: Whib; pfam02467
526225010741 chaperonin GroEL; Reviewed; Region: groEL; PRK12849
526225010742 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
526225010743 ring oligomerisation interface [polypeptide binding]; other site
526225010744 ATP/Mg binding site [chemical binding]; other site
526225010745 stacking interactions; other site
526225010746 hinge regions; other site
526225010747 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
526225010748 oligomerisation interface [polypeptide binding]; other site
526225010749 mobile loop; other site
526225010750 roof hairpin; other site
526225010751 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225010752 S-adenosylmethionine binding site [chemical binding]; other site
526225010753 UGMP family protein; Validated; Region: PRK09604
526225010754 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
526225010755 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526225010756 Coenzyme A binding pocket [chemical binding]; other site
526225010757 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
526225010758 Glycoprotease family; Region: Peptidase_M22; pfam00814
526225010759 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
526225010760 nudix motif; other site
526225010761 Predicted ATPase or kinase [General function prediction only]; Region: COG0802
526225010762 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
526225010763 Fe-S cluster binding site [ion binding]; other site
526225010764 active site
526225010765 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526225010766 Putative lysophospholipase; Region: Hydrolase_4; pfam12146
526225010767 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
526225010768 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
526225010769 alanine racemase; Reviewed; Region: alr; PRK00053
526225010770 active site
526225010771 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
526225010772 dimer interface [polypeptide binding]; other site
526225010773 substrate binding site [chemical binding]; other site
526225010774 catalytic residues [active]
526225010775 Uncharacterized conserved protein [Function unknown]; Region: COG0062
526225010776 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
526225010777 putative substrate binding site [chemical binding]; other site
526225010778 putative ATP binding site [chemical binding]; other site
526225010779 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
526225010780 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
526225010781 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
526225010782 glutaminase active site [active]
526225010783 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
526225010784 dimer interface [polypeptide binding]; other site
526225010785 active site
526225010786 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
526225010787 dimer interface [polypeptide binding]; other site
526225010788 active site
526225010789 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
526225010790 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
526225010791 active site
526225010792 substrate binding site [chemical binding]; other site
526225010793 metal binding site [ion binding]; metal-binding site
526225010794 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
526225010795 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
526225010796 23S rRNA interface [nucleotide binding]; other site
526225010797 L3 interface [polypeptide binding]; other site
526225010798 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
526225010799 active site clefts [active]
526225010800 zinc binding site [ion binding]; other site
526225010801 dimer interface [polypeptide binding]; other site
526225010802 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
526225010803 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
526225010804 dimer interface [polypeptide binding]; other site
526225010805 putative functional site; other site
526225010806 putative MPT binding site; other site
526225010807 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364
526225010808 trimer interface [polypeptide binding]; other site
526225010809 dimer interface [polypeptide binding]; other site
526225010810 putative active site [active]
526225010811 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
526225010812 MPT binding site; other site
526225010813 trimer interface [polypeptide binding]; other site
526225010814 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
526225010815 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526225010816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225010817 NADH(P)-binding; Region: NAD_binding_10; pfam13460
526225010818 NAD(P) binding site [chemical binding]; other site
526225010819 active site
526225010820 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
526225010821 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570
526225010822 dimerization interface 3.5A [polypeptide binding]; other site
526225010823 active site
526225010824 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
526225010825 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
526225010826 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
526225010827 alphaNTD homodimer interface [polypeptide binding]; other site
526225010828 alphaNTD - beta interaction site [polypeptide binding]; other site
526225010829 alphaNTD - beta' interaction site [polypeptide binding]; other site
526225010830 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
526225010831 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
526225010832 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
526225010833 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
526225010834 RNA binding surface [nucleotide binding]; other site
526225010835 30S ribosomal protein S11; Validated; Region: PRK05309
526225010836 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
526225010837 30S ribosomal protein S13; Region: bact_S13; TIGR03631
526225010838 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
526225010839 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
526225010840 rRNA binding site [nucleotide binding]; other site
526225010841 predicted 30S ribosome binding site; other site
526225010842 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
526225010843 active site
526225010844 adenylate kinase; Reviewed; Region: adk; PRK00279
526225010845 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
526225010846 AMP-binding site [chemical binding]; other site
526225010847 ATP-AMP (Ap5A)-binding site [chemical binding]; other site
526225010848 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
526225010849 SecY translocase; Region: SecY; pfam00344
526225010850 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
526225010851 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
526225010852 23S rRNA binding site [nucleotide binding]; other site
526225010853 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
526225010854 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
526225010855 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
526225010856 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
526225010857 5S rRNA interface [nucleotide binding]; other site
526225010858 23S rRNA interface [nucleotide binding]; other site
526225010859 L5 interface [polypeptide binding]; other site
526225010860 50S ribosomal protein L6; Validated; Region: rplF; PRK05498
526225010861 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
526225010862 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
526225010863 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
526225010864 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
526225010865 50S ribosomal protein L5; Validated; Region: rplE; PRK00010
526225010866 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
526225010867 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
526225010868 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
526225010869 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
526225010870 RNA binding site [nucleotide binding]; other site
526225010871 50S ribosomal protein L14; Validated; Region: rplN; PRK05483
526225010872 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
526225010873 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
526225010874 putative translocon interaction site; other site
526225010875 23S rRNA interface [nucleotide binding]; other site
526225010876 signal recognition particle (SRP54) interaction site; other site
526225010877 L23 interface [polypeptide binding]; other site
526225010878 trigger factor interaction site; other site
526225010879 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
526225010880 23S rRNA interface [nucleotide binding]; other site
526225010881 5S rRNA interface [nucleotide binding]; other site
526225010882 putative antibiotic binding site [chemical binding]; other site
526225010883 L25 interface [polypeptide binding]; other site
526225010884 L27 interface [polypeptide binding]; other site
526225010885 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
526225010886 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412
526225010887 G-X-X-G motif; other site
526225010888 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
526225010889 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
526225010890 putative translocon binding site; other site
526225010891 protein-rRNA interface [nucleotide binding]; other site
526225010892 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
526225010893 50S ribosomal protein L2; Validated; Region: rplB; PRK09374
526225010894 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
526225010895 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
526225010896 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
526225010897 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
526225010898 50S ribosomal protein L3; Validated; Region: rplC; PRK00001
526225010899 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
526225010900 elongation factor Tu; Reviewed; Region: PRK00049
526225010901 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
526225010902 G1 box; other site
526225010903 GEF interaction site [polypeptide binding]; other site
526225010904 GTP/Mg2+ binding site [chemical binding]; other site
526225010905 Switch I region; other site
526225010906 G2 box; other site
526225010907 G3 box; other site
526225010908 Switch II region; other site
526225010909 G4 box; other site
526225010910 G5 box; other site
526225010911 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
526225010912 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
526225010913 Antibiotic Binding Site [chemical binding]; other site
526225010914 elongation factor G; Reviewed; Region: PRK00007
526225010915 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
526225010916 G1 box; other site
526225010917 putative GEF interaction site [polypeptide binding]; other site
526225010918 GTP/Mg2+ binding site [chemical binding]; other site
526225010919 Switch I region; other site
526225010920 G2 box; other site
526225010921 G3 box; other site
526225010922 Switch II region; other site
526225010923 G4 box; other site
526225010924 G5 box; other site
526225010925 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
526225010926 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
526225010927 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
526225010928 30S ribosomal protein S7; Validated; Region: PRK05302
526225010929 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
526225010930 S17 interaction site [polypeptide binding]; other site
526225010931 S8 interaction site; other site
526225010932 16S rRNA interaction site [nucleotide binding]; other site
526225010933 streptomycin interaction site [chemical binding]; other site
526225010934 23S rRNA interaction site [nucleotide binding]; other site
526225010935 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
526225010936 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
526225010937 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
526225010938 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
526225010939 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
526225010940 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
526225010941 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
526225010942 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
526225010943 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
526225010944 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
526225010945 G-loop; other site
526225010946 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
526225010947 DNA binding site [nucleotide binding]
526225010948 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
526225010949 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
526225010950 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
526225010951 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
526225010952 RPB10 interaction site [polypeptide binding]; other site
526225010953 RPB1 interaction site [polypeptide binding]; other site
526225010954 RPB11 interaction site [polypeptide binding]; other site
526225010955 RPB3 interaction site [polypeptide binding]; other site
526225010956 RPB12 interaction site [polypeptide binding]; other site
526225010957 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
526225010958 core dimer interface [polypeptide binding]; other site
526225010959 peripheral dimer interface [polypeptide binding]; other site
526225010960 L10 interface [polypeptide binding]; other site
526225010961 L11 interface [polypeptide binding]; other site
526225010962 putative EF-Tu interaction site [polypeptide binding]; other site
526225010963 putative EF-G interaction site [polypeptide binding]; other site
526225010964 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
526225010965 23S rRNA interface [nucleotide binding]; other site
526225010966 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
526225010967 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
526225010968 mRNA/rRNA interface [nucleotide binding]; other site
526225010969 50S ribosomal protein L11; Validated; Region: rplK; PRK00140
526225010970 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
526225010971 23S rRNA interface [nucleotide binding]; other site
526225010972 L7/L12 interface [polypeptide binding]; other site
526225010973 putative thiostrepton binding site; other site
526225010974 L25 interface [polypeptide binding]; other site
526225010975 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
526225010976 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
526225010977 putative homodimer interface [polypeptide binding]; other site
526225010978 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
526225010979 heterodimer interface [polypeptide binding]; other site
526225010980 homodimer interface [polypeptide binding]; other site
526225010981 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
526225010982 aspartate aminotransferase; Provisional; Region: PRK05764
526225010983 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
526225010984 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225010985 homodimer interface [polypeptide binding]; other site
526225010986 catalytic residue [active]
526225010987 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
526225010988 Zn binding site [ion binding]; other site
526225010989 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
526225010990 active site
526225010991 catalytic site [active]
526225010992 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
526225010993 active site
526225010994 catalytic site [active]
526225010995 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
526225010996 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199
526225010997 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
526225010998 metal binding site [ion binding]; metal-binding site
526225010999 active site
526225011000 I-site; other site
526225011001 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
526225011002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
526225011003 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
526225011004 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
526225011005 MerR HTH family regulatory protein; Region: MerR_1; pfam13411
526225011006 DNA binding residues [nucleotide binding]
526225011007 dimer interface [polypeptide binding]; other site
526225011008 heat shock protein HtpX; Provisional; Region: PRK03072
526225011009 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
526225011010 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
526225011011 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
526225011012 dimer interface [polypeptide binding]; other site
526225011013 PYR/PP interface [polypeptide binding]; other site
526225011014 TPP binding site [chemical binding]; other site
526225011015 substrate binding site [chemical binding]; other site
526225011016 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
526225011017 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
526225011018 TPP-binding site [chemical binding]; other site
526225011019 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
526225011020 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526225011021 DNA-binding site [nucleotide binding]; DNA binding site
526225011022 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
526225011023 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526225011024 catalytic residue [active]
526225011025 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
526225011026 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
526225011027 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
526225011028 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
526225011029 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
526225011030 substrate binding pocket [chemical binding]; other site
526225011031 chain length determination region; other site
526225011032 substrate-Mg2+ binding site; other site
526225011033 catalytic residues [active]
526225011034 aspartate-rich region 1; other site
526225011035 active site lid residues [active]
526225011036 aspartate-rich region 2; other site
526225011037 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
526225011038 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
526225011039 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
526225011040 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
526225011041 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
526225011042 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
526225011043 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
526225011044 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455
526225011045 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
526225011046 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
526225011047 NADH dehydrogenase subunit J; Provisional; Region: PRK06433
526225011048 NADH dehydrogenase subunit I; Provisional; Region: PRK05888
526225011049 4Fe-4S binding domain; Region: Fer4; pfam00037
526225011050 4Fe-4S binding domain; Region: Fer4; pfam00037
526225011051 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
526225011052 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
526225011053 NADH dehydrogenase subunit G; Validated; Region: PRK07860
526225011054 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526225011055 catalytic loop [active]
526225011056 iron binding site [ion binding]; other site
526225011057 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
526225011058 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
526225011059 molybdopterin cofactor binding site; other site
526225011060 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
526225011061 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
526225011062 SLBB domain; Region: SLBB; pfam10531
526225011063 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
526225011064 NADH dehydrogenase subunit E; Validated; Region: PRK07539
526225011065 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
526225011066 putative dimer interface [polypeptide binding]; other site
526225011067 [2Fe-2S] cluster binding site [ion binding]; other site
526225011068 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
526225011069 NADH dehydrogenase subunit D; Validated; Region: PRK06075
526225011070 NADH dehydrogenase subunit C; Provisional; Region: PRK07785
526225011071 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
526225011072 NADH dehydrogenase subunit B; Validated; Region: PRK06411
526225011073 NADH dehydrogenase subunit A; Validated; Region: PRK07928
526225011074 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
526225011075 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
526225011076 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
526225011077 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225011078 S-adenosylmethionine binding site [chemical binding]; other site
526225011079 chorismate binding enzyme; Region: Chorismate_bind; pfam00425
526225011080 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
526225011081 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
526225011082 dimer interface [polypeptide binding]; other site
526225011083 tetramer interface [polypeptide binding]; other site
526225011084 PYR/PP interface [polypeptide binding]; other site
526225011085 TPP binding site [chemical binding]; other site
526225011086 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
526225011087 TPP-binding site [chemical binding]; other site
526225011088 O-succinylbenzoate synthase; Provisional; Region: PRK02901
526225011089 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
526225011090 active site
526225011091 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526225011092 active site
526225011093 CoA binding site [chemical binding]; other site
526225011094 AMP binding site [chemical binding]; other site
526225011095 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
526225011096 UbiA prenyltransferase family; Region: UbiA; pfam01040
526225011097 Transcriptional regulators [Transcription]; Region: Lrp; COG1522
526225011098 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526225011099 putative DNA binding site [nucleotide binding]; other site
526225011100 putative Zn2+ binding site [ion binding]; other site
526225011101 AsnC family; Region: AsnC_trans_reg; pfam01037
526225011102 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
526225011103 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
526225011104 ResB-like family; Region: ResB; pfam05140
526225011105 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
526225011106 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
526225011107 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
526225011108 Thioredoxin-like; Region: Thioredoxin_8; pfam13905
526225011109 catalytic residues [active]
526225011110 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526225011111 catalytic core [active]
526225011112 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
526225011113 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
526225011114 inhibitor-cofactor binding pocket; inhibition site
526225011115 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225011116 catalytic residue [active]
526225011117 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
526225011118 dimer interface [polypeptide binding]; other site
526225011119 active site
526225011120 Schiff base residues; other site
526225011121 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
526225011122 active site
526225011123 SAM binding site [chemical binding]; other site
526225011124 homodimer interface [polypeptide binding]; other site
526225011125 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
526225011126 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
526225011127 active site
526225011128 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
526225011129 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
526225011130 domain interfaces; other site
526225011131 active site
526225011132 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
526225011133 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
526225011134 tRNA; other site
526225011135 putative tRNA binding site [nucleotide binding]; other site
526225011136 putative NADP binding site [chemical binding]; other site
526225011137 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
526225011138 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
526225011139 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
526225011140 CoA binding domain; Region: CoA_binding; pfam02629
526225011141 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
526225011142 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526225011143 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
526225011144 acyl-activating enzyme (AAE) consensus motif; other site
526225011145 AMP binding site [chemical binding]; other site
526225011146 active site
526225011147 CoA binding site [chemical binding]; other site
526225011148 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
526225011149 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
526225011150 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
526225011151 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
526225011152 putative acyl-acceptor binding pocket; other site
526225011153 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
526225011154 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
526225011155 putative NAD(P) binding site [chemical binding]; other site
526225011156 active site
526225011157 putative substrate binding site [chemical binding]; other site
526225011158 DNA binding domain, excisionase family; Region: excise; TIGR01764
526225011159 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
526225011160 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
526225011161 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
526225011162 intracellular protease, PfpI family; Region: PfpI; TIGR01382
526225011163 proposed catalytic triad [active]
526225011164 conserved cys residue [active]
526225011165 exopolyphosphatase; Region: exo_poly_only; TIGR03706
526225011166 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
526225011167 H+ Antiporter protein; Region: 2A0121; TIGR00900
526225011168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225011169 putative substrate translocation pore; other site
526225011170 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
526225011171 active site
526225011172 Methyltransferase domain; Region: Methyltransf_23; pfam13489
526225011173 Methyltransferase domain; Region: Methyltransf_11; pfam08241
526225011174 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
526225011175 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
526225011176 conserved cys residue [active]
526225011177 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526225011178 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272
526225011179 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526225011180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225011181 active site
526225011182 phosphorylation site [posttranslational modification]
526225011183 intermolecular recognition site; other site
526225011184 dimerization interface [polypeptide binding]; other site
526225011185 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526225011186 DNA binding site [nucleotide binding]
526225011187 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
526225011188 dimer interface [polypeptide binding]; other site
526225011189 phosphorylation site [posttranslational modification]
526225011190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225011191 ATP binding site [chemical binding]; other site
526225011192 G-X-G motif; other site
526225011193 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
526225011194 PhoU domain; Region: PhoU; pfam01895
526225011195 PhoU domain; Region: PhoU; pfam01895
526225011196 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526225011197 catalytic core [active]
526225011198 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
526225011199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225011200 putative substrate translocation pore; other site
526225011201 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
526225011202 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
526225011203 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
526225011204 putative ADP-binding pocket [chemical binding]; other site
526225011205 malonic semialdehyde reductase; Provisional; Region: PRK10538
526225011206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225011207 NAD(P) binding site [chemical binding]; other site
526225011208 active site
526225011209 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
526225011210 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526225011211 Coenzyme A binding pocket [chemical binding]; other site
526225011212 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
526225011213 FAD binding domain; Region: FAD_binding_4; pfam01565
526225011214 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
526225011215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
526225011216 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
526225011217 Protein of unknown function (DUF1059); Region: DUF1059; pfam06348
526225011218 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
526225011219 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
526225011220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
526225011221 RNase III inhibitor; Provisional; Region: PRK00431
526225011222 ADP-ribose binding site [chemical binding]; other site
526225011223 PspC domain; Region: PspC; pfam04024
526225011224 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
526225011225 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526225011226 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526225011227 non-specific DNA binding site [nucleotide binding]; other site
526225011228 salt bridge; other site
526225011229 sequence-specific DNA binding site [nucleotide binding]; other site
526225011230 L-asparaginase II; Region: Asparaginase_II; pfam06089
526225011231 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
526225011232 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
526225011233 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
526225011234 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
526225011235 metal binding site 2 [ion binding]; metal-binding site
526225011236 putative DNA binding helix; other site
526225011237 metal binding site 1 [ion binding]; metal-binding site
526225011238 dimer interface [polypeptide binding]; other site
526225011239 structural Zn2+ binding site [ion binding]; other site
526225011240 Domain of unknown function (DUF4392); Region: DUF4392; pfam14336
526225011241 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK04690
526225011242 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
526225011243 butyrate kinase; Provisional; Region: PRK03011
526225011244 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
526225011245 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853
526225011246 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
526225011247 nitrobindin heme-binding domain; Region: nitrobindin; cd07828
526225011248 heme-binding site [chemical binding]; other site
526225011249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225011250 NAD(P) binding site [chemical binding]; other site
526225011251 active site
526225011252 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
526225011253 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526225011254 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225011255 Predicted transcriptional regulators [Transcription]; Region: COG1695
526225011256 Transcriptional regulator PadR-like family; Region: PadR; pfam03551
526225011257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225011258 Walker A/P-loop; other site
526225011259 ATP binding site [chemical binding]; other site
526225011260 Q-loop/lid; other site
526225011261 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
526225011262 PAS domain; Region: PAS_9; pfam13426
526225011263 putative active site [active]
526225011264 heme pocket [chemical binding]; other site
526225011265 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
526225011266 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210
526225011267 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
526225011268 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
526225011269 active site residue [active]
526225011270 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
526225011271 active site residue [active]
526225011272 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
526225011273 catalytic residues [active]
526225011274 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
526225011275 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526225011276 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526225011277 DNA binding site [nucleotide binding]
526225011278 mycothiol synthase; Region: mycothiol_MshD; TIGR03448
526225011279 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
526225011280 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526225011281 Coenzyme A binding pocket [chemical binding]; other site
526225011282 PBP superfamily domain; Region: PBP_like_2; cl17296
526225011283 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
526225011284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526225011285 conserved gate region; other site
526225011286 ABC-ATPase subunit interface; other site
526225011287 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
526225011288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526225011289 dimer interface [polypeptide binding]; other site
526225011290 conserved gate region; other site
526225011291 putative PBP binding loops; other site
526225011292 ABC-ATPase subunit interface; other site
526225011293 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
526225011294 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
526225011295 Walker A/P-loop; other site
526225011296 ATP binding site [chemical binding]; other site
526225011297 Q-loop/lid; other site
526225011298 ABC transporter signature motif; other site
526225011299 Walker B; other site
526225011300 D-loop; other site
526225011301 H-loop/switch region; other site
526225011302 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
526225011303 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
526225011304 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
526225011305 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
526225011306 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
526225011307 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
526225011308 FAD binding pocket [chemical binding]; other site
526225011309 FAD binding motif [chemical binding]; other site
526225011310 phosphate binding motif [ion binding]; other site
526225011311 NAD binding pocket [chemical binding]; other site
526225011312 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526225011313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225011314 active site
526225011315 phosphorylation site [posttranslational modification]
526225011316 intermolecular recognition site; other site
526225011317 dimerization interface [polypeptide binding]; other site
526225011318 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526225011319 DNA binding site [nucleotide binding]
526225011320 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
526225011321 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
526225011322 dimerization interface [polypeptide binding]; other site
526225011323 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
526225011324 dimer interface [polypeptide binding]; other site
526225011325 phosphorylation site [posttranslational modification]
526225011326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225011327 ATP binding site [chemical binding]; other site
526225011328 Mg2+ binding site [ion binding]; other site
526225011329 G-X-G motif; other site
526225011330 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
526225011331 CoenzymeA binding site [chemical binding]; other site
526225011332 subunit interaction site [polypeptide binding]; other site
526225011333 PHB binding site; other site
526225011334 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
526225011335 active site
526225011336 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
526225011337 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
526225011338 Active Sites [active]
526225011339 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
526225011340 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
526225011341 CysD dimerization site [polypeptide binding]; other site
526225011342 G1 box; other site
526225011343 putative GEF interaction site [polypeptide binding]; other site
526225011344 GTP/Mg2+ binding site [chemical binding]; other site
526225011345 Switch I region; other site
526225011346 G2 box; other site
526225011347 G3 box; other site
526225011348 Switch II region; other site
526225011349 G4 box; other site
526225011350 G5 box; other site
526225011351 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
526225011352 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
526225011353 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
526225011354 FAD binding domain; Region: FAD_binding_4; pfam01565
526225011355 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
526225011356 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
526225011357 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526225011358 catalytic loop [active]
526225011359 iron binding site [ion binding]; other site
526225011360 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799
526225011361 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
526225011362 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
526225011363 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
526225011364 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
526225011365 Cytochrome P450; Region: p450; cl12078
526225011366 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
526225011367 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
526225011368 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
526225011369 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526225011370 ATP binding site [chemical binding]; other site
526225011371 putative Mg++ binding site [ion binding]; other site
526225011372 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526225011373 nucleotide binding region [chemical binding]; other site
526225011374 ATP-binding site [chemical binding]; other site
526225011375 Helicase associated domain (HA2); Region: HA2; pfam04408
526225011376 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
526225011377 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
526225011378 Transcriptional regulators [Transcription]; Region: MarR; COG1846
526225011379 MarR family; Region: MarR; pfam01047
526225011380 MarR family; Region: MarR_2; cl17246
526225011381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225011382 Major Facilitator Superfamily; Region: MFS_1; pfam07690
526225011383 putative substrate translocation pore; other site
526225011384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225011385 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
526225011386 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
526225011387 NAD binding site [chemical binding]; other site
526225011388 catalytic Zn binding site [ion binding]; other site
526225011389 structural Zn binding site [ion binding]; other site
526225011390 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
526225011391 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
526225011392 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526225011393 active site
526225011394 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
526225011395 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
526225011396 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
526225011397 Hemerythrin-like domain; Region: Hr-like; cd12108
526225011398 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
526225011399 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
526225011400 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526225011401 motif II; other site
526225011402 Asp23 family; Region: Asp23; pfam03780
526225011403 Asp23 family; Region: Asp23; pfam03780
526225011404 tetracycline repressor protein TetR; Provisional; Region: PRK13756
526225011405 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225011406 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
526225011407 PRC-barrel domain; Region: PRC; pfam05239
526225011408 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557
526225011409 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526225011410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225011411 active site
526225011412 phosphorylation site [posttranslational modification]
526225011413 intermolecular recognition site; other site
526225011414 dimerization interface [polypeptide binding]; other site
526225011415 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526225011416 DNA binding site [nucleotide binding]
526225011417 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
526225011418 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
526225011419 dimerization interface [polypeptide binding]; other site
526225011420 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
526225011421 dimer interface [polypeptide binding]; other site
526225011422 phosphorylation site [posttranslational modification]
526225011423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225011424 ATP binding site [chemical binding]; other site
526225011425 Mg2+ binding site [ion binding]; other site
526225011426 G-X-G motif; other site
526225011427 Domain of unknown function (DUF222); Region: DUF222; pfam02720
526225011428 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
526225011429 active site
526225011430 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
526225011431 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7
526225011432 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
526225011433 active site
526225011434 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
526225011435 homodimer interface [polypeptide binding]; other site
526225011436 ATP-grasp domain; Region: ATP-grasp_4; cl17255
526225011437 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
526225011438 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423
526225011439 DXD motif; other site
526225011440 Low molecular weight phosphatase family; Region: LMWPc; cd00115
526225011441 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
526225011442 active site
526225011443 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
526225011444 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
526225011445 Multicopper oxidase; Region: Cu-oxidase; pfam00394
526225011446 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
526225011447 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
526225011448 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
526225011449 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
526225011450 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526225011451 putative DNA binding site [nucleotide binding]; other site
526225011452 putative Zn2+ binding site [ion binding]; other site
526225011453 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
526225011454 Major Facilitator Superfamily; Region: MFS_1; pfam07690
526225011455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225011456 putative substrate translocation pore; other site
526225011457 Low molecular weight phosphatase family; Region: LMWPc; cl00105
526225011458 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
526225011459 active site
526225011460 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
526225011461 Low molecular weight phosphatase family; Region: LMWPc; cd00115
526225011462 active site
526225011463 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
526225011464 Low molecular weight phosphatase family; Region: LMWPc; cl00105
526225011465 active site
526225011466 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
526225011467 arsenical-resistance protein; Region: acr3; TIGR00832
526225011468 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526225011469 dimerization interface [polypeptide binding]; other site
526225011470 putative DNA binding site [nucleotide binding]; other site
526225011471 putative Zn2+ binding site [ion binding]; other site
526225011472 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
526225011473 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526225011474 Coenzyme A binding pocket [chemical binding]; other site
526225011475 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
526225011476 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
526225011477 Int/Topo IB signature motif; other site
526225011478 potential protein location (hypothetical protein Gobs_4727 [Geodermatophilus obscurus DSM 43160]) that overlaps RNA (tRNA-K)
526225011479 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
526225011480 anti sigma factor interaction site; other site
526225011481 regulatory phosphorylation site [posttranslational modification]; other site
526225011482 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
526225011483 Beta-lactamase; Region: Beta-lactamase; pfam00144
526225011484 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
526225011485 iron-sulfur cluster [ion binding]; other site
526225011486 [2Fe-2S] cluster binding site [ion binding]; other site
526225011487 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
526225011488 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
526225011489 active site
526225011490 metal binding site [ion binding]; metal-binding site
526225011491 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526225011492 Coenzyme A binding pocket [chemical binding]; other site
526225011493 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
526225011494 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
526225011495 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526225011496 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526225011497 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
526225011498 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526225011499 Transglycosylase; Region: Transgly; pfam00912
526225011500 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
526225011501 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
526225011502 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
526225011503 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970
526225011504 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
526225011505 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
526225011506 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
526225011507 Peptidase family M23; Region: Peptidase_M23; pfam01551
526225011508 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
526225011509 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208
526225011510 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
526225011511 NAD binding site [chemical binding]; other site
526225011512 Phe binding site; other site
526225011513 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362
526225011514 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
526225011515 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
526225011516 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
526225011517 dimerization interface [polypeptide binding]; other site
526225011518 putative ATP binding site [chemical binding]; other site
526225011519 amidophosphoribosyltransferase; Provisional; Region: PRK07847
526225011520 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
526225011521 active site
526225011522 tetramer interface [polypeptide binding]; other site
526225011523 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
526225011524 active site
526225011525 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
526225011526 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
526225011527 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
526225011528 NAD binding site [chemical binding]; other site
526225011529 catalytic Zn binding site [ion binding]; other site
526225011530 substrate binding site [chemical binding]; other site
526225011531 structural Zn binding site [ion binding]; other site
526225011532 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
526225011533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225011534 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
526225011535 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
526225011536 dimerization interface [polypeptide binding]; other site
526225011537 ATP binding site [chemical binding]; other site
526225011538 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
526225011539 dimerization interface [polypeptide binding]; other site
526225011540 ATP binding site [chemical binding]; other site
526225011541 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
526225011542 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
526225011543 putative active site [active]
526225011544 catalytic triad [active]
526225011545 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
526225011546 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
526225011547 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
526225011548 putative active site [active]
526225011549 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526225011550 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
526225011551 ATP binding site [chemical binding]; other site
526225011552 active site
526225011553 substrate binding site [chemical binding]; other site
526225011554 adenylosuccinate lyase; Provisional; Region: PRK07492
526225011555 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
526225011556 tetramer interface [polypeptide binding]; other site
526225011557 active site
526225011558 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
526225011559 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
526225011560 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
526225011561 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
526225011562 ATP-grasp domain; Region: ATP-grasp_4; cl17255
526225011563 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
526225011564 GTPase RsgA; Reviewed; Region: PRK01889
526225011565 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
526225011566 GTPase/Zn-binding domain interface [polypeptide binding]; other site
526225011567 GTP/Mg2+ binding site [chemical binding]; other site
526225011568 G4 box; other site
526225011569 G5 box; other site
526225011570 G1 box; other site
526225011571 Switch I region; other site
526225011572 G2 box; other site
526225011573 G3 box; other site
526225011574 Switch II region; other site
526225011575 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
526225011576 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
526225011577 active site
526225011578 catalytic site [active]
526225011579 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
526225011580 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
526225011581 GDP-binding site [chemical binding]; other site
526225011582 ACT binding site; other site
526225011583 IMP binding site; other site
526225011584 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
526225011585 fructose-bisphosphate aldolase; Provisional; Region: PRK09197
526225011586 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
526225011587 active site
526225011588 intersubunit interface [polypeptide binding]; other site
526225011589 zinc binding site [ion binding]; other site
526225011590 Na+ binding site [ion binding]; other site
526225011591 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
526225011592 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
526225011593 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
526225011594 active site
526225011595 Fasciclin domain; Region: Fasciclin; pfam02469
526225011596 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
526225011597 Fasciclin domain; Region: Fasciclin; pfam02469
526225011598 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
526225011599 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
526225011600 Moco binding site; other site
526225011601 metal coordination site [ion binding]; other site
526225011602 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
526225011603 Clp amino terminal domain; Region: Clp_N; pfam02861
526225011604 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526225011605 Walker A motif; other site
526225011606 ATP binding site [chemical binding]; other site
526225011607 Walker B motif; other site
526225011608 arginine finger; other site
526225011609 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526225011610 Walker A motif; other site
526225011611 ATP binding site [chemical binding]; other site
526225011612 Walker B motif; other site
526225011613 arginine finger; other site
526225011614 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
526225011615 Transcriptional regulators [Transcription]; Region: MarR; COG1846
526225011616 MarR family; Region: MarR; pfam01047
526225011617 OsmC-like protein; Region: OsmC; cl00767
526225011618 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
526225011619 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
526225011620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225011621 putative substrate translocation pore; other site
526225011622 MarR family; Region: MarR; pfam01047
526225011623 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
526225011624 Transcriptional regulator [Transcription]; Region: IclR; COG1414
526225011625 Bacterial transcriptional regulator; Region: IclR; pfam01614
526225011626 malate synthase A; Region: malate_syn_A; TIGR01344
526225011627 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
526225011628 active site
526225011629 FAD binding domain; Region: FAD_binding_4; pfam01565
526225011630 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
526225011631 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
526225011632 FAD binding domain; Region: FAD_binding_4; pfam01565
526225011633 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
526225011634 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
526225011635 Cysteine-rich domain; Region: CCG; pfam02754
526225011636 Cysteine-rich domain; Region: CCG; pfam02754
526225011637 glycolate transporter; Provisional; Region: PRK09695
526225011638 L-lactate permease; Region: Lactate_perm; cl00701
526225011639 L-lactate permease; Region: Lactate_perm; cl00701
526225011640 Transcriptional regulators [Transcription]; Region: MarR; COG1846
526225011641 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526225011642 putative DNA binding site [nucleotide binding]; other site
526225011643 putative Zn2+ binding site [ion binding]; other site
526225011644 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
526225011645 DNA binding residues [nucleotide binding]
526225011646 MerR HTH family regulatory protein; Region: MerR_1; pfam13411
526225011647 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
526225011648 HSP70 interaction site [polypeptide binding]; other site
526225011649 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684
526225011650 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
526225011651 Zn binding sites [ion binding]; other site
526225011652 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
526225011653 dimer interface [polypeptide binding]; other site
526225011654 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
526225011655 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
526225011656 dimer interface [polypeptide binding]; other site
526225011657 hsp70 (ATPase domain) interactions [polypeptide binding]; other site
526225011658 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
526225011659 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
526225011660 nucleotide binding site [chemical binding]; other site
526225011661 NEF interaction site [polypeptide binding]; other site
526225011662 SBD interface [polypeptide binding]; other site
526225011663 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
526225011664 4Fe-4S binding domain; Region: Fer4; pfam00037
526225011665 Cysteine-rich domain; Region: CCG; pfam02754
526225011666 Cysteine-rich domain; Region: CCG; pfam02754
526225011667 cyanate transporter; Region: CynX; TIGR00896
526225011668 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
526225011669 trimer interface [polypeptide binding]; other site
526225011670 active site
526225011671 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
526225011672 catalytic triad [active]
526225011673 putative active site [active]
526225011674 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
526225011675 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
526225011676 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
526225011677 dimer interface [polypeptide binding]; other site
526225011678 phosphorylation site [posttranslational modification]
526225011679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225011680 ATP binding site [chemical binding]; other site
526225011681 Mg2+ binding site [ion binding]; other site
526225011682 G-X-G motif; other site
526225011683 Response regulator receiver domain; Region: Response_reg; pfam00072
526225011684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225011685 active site
526225011686 phosphorylation site [posttranslational modification]
526225011687 intermolecular recognition site; other site
526225011688 dimerization interface [polypeptide binding]; other site
526225011689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
526225011690 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
526225011691 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
526225011692 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
526225011693 GAF domain; Region: GAF_2; pfam13185
526225011694 GAF domain; Region: GAF; pfam01590
526225011695 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
526225011696 Histidine kinase; Region: HisKA_3; pfam07730
526225011697 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225011698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225011699 active site
526225011700 phosphorylation site [posttranslational modification]
526225011701 intermolecular recognition site; other site
526225011702 dimerization interface [polypeptide binding]; other site
526225011703 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225011704 DNA binding residues [nucleotide binding]
526225011705 dimerization interface [polypeptide binding]; other site
526225011706 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
526225011707 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
526225011708 malonyl-CoA binding site [chemical binding]; other site
526225011709 dimer interface [polypeptide binding]; other site
526225011710 active site
526225011711 product binding site; other site
526225011712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225011713 S-adenosylmethionine binding site [chemical binding]; other site
526225011714 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338
526225011715 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
526225011716 substrate binding site [chemical binding]; other site
526225011717 ATP binding site [chemical binding]; other site
526225011718 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526225011719 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225011720 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
526225011721 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
526225011722 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526225011723 active site
526225011724 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
526225011725 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225011726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225011727 active site
526225011728 phosphorylation site [posttranslational modification]
526225011729 intermolecular recognition site; other site
526225011730 dimerization interface [polypeptide binding]; other site
526225011731 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225011732 DNA binding residues [nucleotide binding]
526225011733 dimerization interface [polypeptide binding]; other site
526225011734 Histidine kinase; Region: HisKA_3; pfam07730
526225011735 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
526225011736 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
526225011737 ABC-2 type transporter; Region: ABC2_membrane; cl17235
526225011738 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
526225011739 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
526225011740 Walker A/P-loop; other site
526225011741 ATP binding site [chemical binding]; other site
526225011742 Q-loop/lid; other site
526225011743 ABC transporter signature motif; other site
526225011744 Walker B; other site
526225011745 D-loop; other site
526225011746 H-loop/switch region; other site
526225011747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225011748 short chain dehydrogenase; Provisional; Region: PRK07577
526225011749 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526225011750 active site
526225011751 GAF domain; Region: GAF; pfam01590
526225011752 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
526225011753 Tannase and feruloyl esterase; Region: Tannase; pfam07519
526225011754 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
526225011755 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
526225011756 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199
526225011757 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
526225011758 metal binding site [ion binding]; metal-binding site
526225011759 active site
526225011760 I-site; other site
526225011761 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
526225011762 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
526225011763 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
526225011764 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
526225011765 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
526225011766 DeoR C terminal sensor domain; Region: DeoRC; pfam00455
526225011767 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
526225011768 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
526225011769 putative substrate binding site [chemical binding]; other site
526225011770 putative ATP binding site [chemical binding]; other site
526225011771 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
526225011772 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526225011773 active site
526225011774 phosphorylation site [posttranslational modification]
526225011775 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
526225011776 active site
526225011777 P-loop; other site
526225011778 phosphorylation site [posttranslational modification]
526225011779 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
526225011780 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
526225011781 dimerization domain swap beta strand [polypeptide binding]; other site
526225011782 regulatory protein interface [polypeptide binding]; other site
526225011783 active site
526225011784 regulatory phosphorylation site [posttranslational modification]; other site
526225011785 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
526225011786 putative hydrophobic ligand binding site [chemical binding]; other site
526225011787 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
526225011788 putative active cleft [active]
526225011789 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
526225011790 E3 interaction surface; other site
526225011791 lipoyl attachment site [posttranslational modification]; other site
526225011792 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
526225011793 e3 binding domain; Region: E3_binding; pfam02817
526225011794 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
526225011795 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
526225011796 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
526225011797 alpha subunit interface [polypeptide binding]; other site
526225011798 TPP binding site [chemical binding]; other site
526225011799 heterodimer interface [polypeptide binding]; other site
526225011800 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
526225011801 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
526225011802 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
526225011803 TPP-binding site [chemical binding]; other site
526225011804 heterodimer interface [polypeptide binding]; other site
526225011805 tetramer interface [polypeptide binding]; other site
526225011806 phosphorylation loop region [posttranslational modification]
526225011807 Transcriptional regulators [Transcription]; Region: Lrp; COG1522
526225011808 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
526225011809 AsnC family; Region: AsnC_trans_reg; pfam01037
526225011810 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625
526225011811 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512
526225011812 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
526225011813 Beta-lactamase; Region: Beta-lactamase; pfam00144
526225011814 Domain of unknown function (DUF3817); Region: DUF3817; cl14844
526225011815 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
526225011816 NlpC/P60 family; Region: NLPC_P60; pfam00877
526225011817 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
526225011818 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526225011819 Transglycosylase; Region: Transgly; pfam00912
526225011820 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
526225011821 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
526225011822 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
526225011823 Part of AAA domain; Region: AAA_19; pfam13245
526225011824 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
526225011825 active site residue [active]
526225011826 Major Facilitator Superfamily; Region: MFS_1; pfam07690
526225011827 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
526225011828 active site
526225011829 substrate-binding site [chemical binding]; other site
526225011830 metal-binding site [ion binding]
526225011831 GTP binding site [chemical binding]; other site
526225011832 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
526225011833 putative hydrophobic ligand binding site [chemical binding]; other site
526225011834 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526225011835 dimerization interface [polypeptide binding]; other site
526225011836 putative DNA binding site [nucleotide binding]; other site
526225011837 putative Zn2+ binding site [ion binding]; other site
526225011838 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
526225011839 FMN binding site [chemical binding]; other site
526225011840 substrate binding site [chemical binding]; other site
526225011841 putative catalytic residue [active]
526225011842 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
526225011843 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
526225011844 catalytic residues [active]
526225011845 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
526225011846 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
526225011847 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526225011848 classical (c) SDRs; Region: SDR_c; cd05233
526225011849 NAD(P) binding site [chemical binding]; other site
526225011850 active site
526225011851 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
526225011852 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
526225011853 Ca binding site [ion binding]; other site
526225011854 active site
526225011855 catalytic site [active]
526225011856 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
526225011857 H+ Antiporter protein; Region: 2A0121; TIGR00900
526225011858 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526225011859 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
526225011860 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
526225011861 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
526225011862 DeoR C terminal sensor domain; Region: DeoRC; pfam00455
526225011863 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
526225011864 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
526225011865 acyl-activating enzyme (AAE) consensus motif; other site
526225011866 putative AMP binding site [chemical binding]; other site
526225011867 putative active site [active]
526225011868 putative CoA binding site [chemical binding]; other site
526225011869 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
526225011870 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
526225011871 catalytic residues [active]
526225011872 dimer interface [polypeptide binding]; other site
526225011873 EamA-like transporter family; Region: EamA; pfam00892
526225011874 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
526225011875 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526225011876 BCCT family transporter; Region: BCCT; pfam02028
526225011877 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
526225011878 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
526225011879 Mechanosensitive ion channel; Region: MS_channel; pfam00924
526225011880 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
526225011881 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
526225011882 NAD(P) binding site [chemical binding]; other site
526225011883 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812
526225011884 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
526225011885 homodimer interface [polypeptide binding]; other site
526225011886 substrate-cofactor binding pocket; other site
526225011887 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225011888 catalytic residue [active]
526225011889 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
526225011890 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
526225011891 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
526225011892 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
526225011893 trimer interface [polypeptide binding]; other site
526225011894 putative metal binding site [ion binding]; other site
526225011895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
526225011896 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
526225011897 NlpC/P60 family; Region: NLPC_P60; pfam00877
526225011898 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
526225011899 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
526225011900 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
526225011901 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
526225011902 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
526225011903 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
526225011904 homotrimer interaction site [polypeptide binding]; other site
526225011905 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
526225011906 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
526225011907 active site
526225011908 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
526225011909 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
526225011910 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
526225011911 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526225011912 motif II; other site
526225011913 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
526225011914 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
526225011915 putative hydrophobic ligand binding site [chemical binding]; other site
526225011916 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
526225011917 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
526225011918 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416
526225011919 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
526225011920 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
526225011921 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
526225011922 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526225011923 catalytic loop [active]
526225011924 iron binding site [ion binding]; other site
526225011925 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799
526225011926 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
526225011927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526225011928 putative substrate translocation pore; other site
526225011929 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
526225011930 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
526225011931 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526225011932 active site
526225011933 Isochorismatase family; Region: Isochorismatase; pfam00857
526225011934 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
526225011935 catalytic triad [active]
526225011936 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964
526225011937 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
526225011938 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
526225011939 phosphate binding site [ion binding]; other site
526225011940 hypothetical protein; Provisional; Region: PRK04233
526225011941 SEC-C motif; Region: SEC-C; pfam02810
526225011942 Domain of unknown function (DUF222); Region: DUF222; pfam02720
526225011943 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
526225011944 active site
526225011945 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
526225011946 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
526225011947 mycofactocin system FadH/OYE family oxidoreductase 1; Region: mycofact_OYE_1; TIGR03996
526225011948 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
526225011949 phosphate binding site [ion binding]; other site
526225011950 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962
526225011951 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526225011952 FeS/SAM binding site; other site
526225011953 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
526225011954 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967
526225011955 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
526225011956 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526225011957 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526225011958 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526225011959 active site
526225011960 catalytic tetrad [active]
526225011961 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526225011962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225011963 active site
526225011964 phosphorylation site [posttranslational modification]
526225011965 intermolecular recognition site; other site
526225011966 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526225011967 DNA binding residues [nucleotide binding]
526225011968 dimerization interface [polypeptide binding]; other site
526225011969 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
526225011970 Histidine kinase; Region: HisKA_3; pfam07730
526225011971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225011972 ATP binding site [chemical binding]; other site
526225011973 Mg2+ binding site [ion binding]; other site
526225011974 G-X-G motif; other site
526225011975 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
526225011976 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
526225011977 active site
526225011978 NAD binding site [chemical binding]; other site
526225011979 metal binding site [ion binding]; metal-binding site
526225011980 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
526225011981 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
526225011982 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526225011983 catalytic residue [active]
526225011984 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
526225011985 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
526225011986 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
526225011987 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
526225011988 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
526225011989 NAD binding site [chemical binding]; other site
526225011990 catalytic Zn binding site [ion binding]; other site
526225011991 substrate binding site [chemical binding]; other site
526225011992 structural Zn binding site [ion binding]; other site
526225011993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526225011994 ATPases associated with a variety of cellular activities; Region: AAA; smart00382
526225011995 Walker A motif; other site
526225011996 ATP binding site [chemical binding]; other site
526225011997 Walker B motif; other site
526225011998 arginine finger; other site
526225011999 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
526225012000 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
526225012001 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
526225012002 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
526225012003 XdhC Rossmann domain; Region: XdhC_C; pfam13478
526225012004 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
526225012005 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
526225012006 metal ion-dependent adhesion site (MIDAS); other site
526225012007 MoxR-like ATPases [General function prediction only]; Region: COG0714
526225012008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526225012009 Walker A motif; other site
526225012010 ATP binding site [chemical binding]; other site
526225012011 Walker B motif; other site
526225012012 arginine finger; other site
526225012013 PRC-barrel domain; Region: PRC; pfam05239
526225012014 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557
526225012015 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
526225012016 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526225012017 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526225012018 active site
526225012019 catalytic tetrad [active]
526225012020 hypothetical protein; Provisional; Region: PRK01346
526225012021 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
526225012022 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
526225012023 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526225012024 FeS/SAM binding site; other site
526225012025 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
526225012026 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
526225012027 MoaE interaction surface [polypeptide binding]; other site
526225012028 MoeB interaction surface [polypeptide binding]; other site
526225012029 thiocarboxylated glycine; other site
526225012030 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
526225012031 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
526225012032 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
526225012033 MoaD interaction [polypeptide binding]; other site
526225012034 active site residues [active]
526225012035 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
526225012036 metal-binding site
526225012037 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526225012038 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
526225012039 Walker A/P-loop; other site
526225012040 ATP binding site [chemical binding]; other site
526225012041 Q-loop/lid; other site
526225012042 ABC transporter signature motif; other site
526225012043 Walker B; other site
526225012044 D-loop; other site
526225012045 H-loop/switch region; other site
526225012046 TOBE domain; Region: TOBE; pfam03459
526225012047 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
526225012048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526225012049 dimer interface [polypeptide binding]; other site
526225012050 conserved gate region; other site
526225012051 putative PBP binding loops; other site
526225012052 ABC-ATPase subunit interface; other site
526225012053 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
526225012054 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
526225012055 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
526225012056 MerR HTH family regulatory protein; Region: MerR_1; pfam13411
526225012057 DNA binding residues [nucleotide binding]
526225012058 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
526225012059 MASE1; Region: MASE1; cl17823
526225012060 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
526225012061 metal binding site [ion binding]; metal-binding site
526225012062 active site
526225012063 I-site; other site
526225012064 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
526225012065 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
526225012066 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526225012067 ATP binding site [chemical binding]; other site
526225012068 putative Mg++ binding site [ion binding]; other site
526225012069 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526225012070 nucleotide binding region [chemical binding]; other site
526225012071 ATP-binding site [chemical binding]; other site
526225012072 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
526225012073 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
526225012074 Carbamoyltransferase; Region: CmcH_NodU; pfam02543
526225012075 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325
526225012076 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526225012077 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526225012078 active site
526225012079 Domain of unknown function (DU1801); Region: DUF1801; pfam08818
526225012080 Transcriptional regulator [Transcription]; Region: LytR; COG1316
526225012081 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
526225012082 putative catalytic site [active]
526225012083 putative phosphate binding site [ion binding]; other site
526225012084 active site
526225012085 metal binding site A [ion binding]; metal-binding site
526225012086 DNA binding site [nucleotide binding]
526225012087 putative AP binding site [nucleotide binding]; other site
526225012088 putative metal binding site B [ion binding]; other site
526225012089 spore photoproduct lyase; Region: photo_TT_lyase; cl15393
526225012090 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
526225012091 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
526225012092 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
526225012093 NAD binding site [chemical binding]; other site
526225012094 catalytic Zn binding site [ion binding]; other site
526225012095 structural Zn binding site [ion binding]; other site
526225012096 hypothetical protein; Validated; Region: PRK02101
526225012097 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
526225012098 GAF domain; Region: GAF; pfam01590
526225012099 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
526225012100 PAS fold; Region: PAS_3; pfam08447
526225012101 putative active site [active]
526225012102 heme pocket [chemical binding]; other site
526225012103 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
526225012104 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
526225012105 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
526225012106 amidase; Provisional; Region: PRK07486
526225012107 Amidase; Region: Amidase; pfam01425
526225012108 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
526225012109 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
526225012110 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
526225012111 Membrane protein of unknown function; Region: DUF360; pfam04020
526225012112 Protein of unknown function, DUF393; Region: DUF393; pfam04134
526225012113 AAA ATPase domain; Region: AAA_16; pfam13191
526225012114 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526225012115 Putative lysophospholipase; Region: Hydrolase_4; pfam12146
526225012116 GAF domain; Region: GAF; pfam01590
526225012117 GAF domain; Region: GAF_2; pfam13185
526225012118 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
526225012119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225012120 ATP binding site [chemical binding]; other site
526225012121 Mg2+ binding site [ion binding]; other site
526225012122 G-X-G motif; other site
526225012123 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
526225012124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225012125 active site
526225012126 phosphorylation site [posttranslational modification]
526225012127 intermolecular recognition site; other site
526225012128 dimerization interface [polypeptide binding]; other site
526225012129 Chemotaxis phosphatase CheX; Region: CheX; pfam13690
526225012130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225012131 Response regulator receiver domain; Region: Response_reg; pfam00072
526225012132 active site
526225012133 phosphorylation site [posttranslational modification]
526225012134 intermolecular recognition site; other site
526225012135 dimerization interface [polypeptide binding]; other site
526225012136 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
526225012137 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
526225012138 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225012139 chemotaxis-specific methylesterase; Provisional; Region: PRK00742
526225012140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526225012141 active site
526225012142 phosphorylation site [posttranslational modification]
526225012143 intermolecular recognition site; other site
526225012144 dimerization interface [polypeptide binding]; other site
526225012145 CheB methylesterase; Region: CheB_methylest; pfam01339
526225012146 glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091
526225012147 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
526225012148 oligomer interface; other site
526225012149 ligand binding site; other site
526225012150 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
526225012151 dimer interface [polypeptide binding]; other site
526225012152 N-terminal domain interface [polypeptide binding]; other site
526225012153 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
526225012154 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
526225012155 putative binding surface; other site
526225012156 active site
526225012157 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
526225012158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526225012159 ATP binding site [chemical binding]; other site
526225012160 Mg2+ binding site [ion binding]; other site
526225012161 G-X-G motif; other site
526225012162 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
526225012163 CheW-like domain; Region: CheW; pfam01584
526225012164 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
526225012165 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
526225012166 dimer interface [polypeptide binding]; other site
526225012167 putative CheW interface [polypeptide binding]; other site
526225012168 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
526225012169 dimerization interface [polypeptide binding]; other site
526225012170 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
526225012171 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
526225012172 dimer interface [polypeptide binding]; other site
526225012173 putative CheW interface [polypeptide binding]; other site
526225012174 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
526225012175 dimerization interface [polypeptide binding]; other site
526225012176 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
526225012177 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
526225012178 dimer interface [polypeptide binding]; other site
526225012179 putative CheW interface [polypeptide binding]; other site
526225012180 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
526225012181 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
526225012182 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
526225012183 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
526225012184 active site
526225012185 homotetramer interface [polypeptide binding]; other site
526225012186 CrcB-like protein; Region: CRCB; pfam02537
526225012187 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
526225012188 Integral membrane protein TerC family; Region: TerC; cl10468
526225012189 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526225012190 putative Zn2+ binding site [ion binding]; other site
526225012191 putative DNA binding site [nucleotide binding]; other site
526225012192 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT
526225012193 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
526225012194 ATP-grasp domain; Region: ATP-grasp_4; cl17255
526225012195 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
526225012196 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712
526225012197 active site
526225012198 dimer interface [polypeptide binding]; other site
526225012199 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991
526225012200 Ligand Binding Site [chemical binding]; other site
526225012201 Molecular Tunnel; other site
526225012202 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
526225012203 Quinone oxidoreductase (QOR); Region: QOR2; cd05286
526225012204 NADP binding site [chemical binding]; other site
526225012205 dimer interface [polypeptide binding]; other site
526225012206 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526225012207 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526225012208 non-specific DNA binding site [nucleotide binding]; other site
526225012209 salt bridge; other site
526225012210 sequence-specific DNA binding site [nucleotide binding]; other site
526225012211 SnoaL-like domain; Region: SnoaL_2; pfam12680
526225012212 Protein of unknown function (DUF1330); Region: DUF1330; cl02288
526225012213 TAP-like protein; Region: Abhydrolase_4; pfam08386
526225012214 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
526225012215 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
526225012216 Walker A/P-loop; other site
526225012217 ATP binding site [chemical binding]; other site
526225012218 Q-loop/lid; other site
526225012219 ABC transporter signature motif; other site
526225012220 Walker B; other site
526225012221 D-loop; other site
526225012222 H-loop/switch region; other site
526225012223 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
526225012224 ABC-ATPase subunit interface; other site
526225012225 dimer interface [polypeptide binding]; other site
526225012226 putative PBP binding regions; other site
526225012227 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
526225012228 ABC-ATPase subunit interface; other site
526225012229 dimer interface [polypeptide binding]; other site
526225012230 putative PBP binding regions; other site
526225012231 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
526225012232 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
526225012233 putative ligand binding residues [chemical binding]; other site
526225012234 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526225012235 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526225012236 active site
526225012237 catalytic tetrad [active]
526225012238 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
526225012239 PAS domain; Region: PAS_9; pfam13426
526225012240 putative active site [active]
526225012241 heme pocket [chemical binding]; other site
526225012242 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
526225012243 GAF domain; Region: GAF; pfam01590
526225012244 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
526225012245 Flavin reductase like domain; Region: Flavin_Reduct; smart00903
526225012246 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
526225012247 active site
526225012248 catalytic residues [active]
526225012249 metal binding site [ion binding]; metal-binding site
526225012250 PAS domain S-box; Region: sensory_box; TIGR00229
526225012251 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
526225012252 putative active site [active]
526225012253 heme pocket [chemical binding]; other site
526225012254 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199
526225012255 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
526225012256 metal binding site [ion binding]; metal-binding site
526225012257 active site
526225012258 I-site; other site
526225012259 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651
526225012260 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
526225012261 metal binding site [ion binding]; metal-binding site
526225012262 dimer interface [polypeptide binding]; other site
526225012263 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
526225012264 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
526225012265 Transcriptional regulator [Transcription]; Region: IclR; COG1414
526225012266 Bacterial transcriptional regulator; Region: IclR; pfam01614
526225012267 glycerol kinase; Provisional; Region: glpK; PRK00047
526225012268 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
526225012269 nucleotide binding site [chemical binding]; other site
526225012270 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
526225012271 amphipathic channel; other site
526225012272 Asn-Pro-Ala signature motifs; other site
526225012273 glycerol kinase; Provisional; Region: glpK; PRK00047
526225012274 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
526225012275 N- and C-terminal domain interface [polypeptide binding]; other site
526225012276 active site
526225012277 MgATP binding site [chemical binding]; other site
526225012278 catalytic site [active]
526225012279 metal binding site [ion binding]; metal-binding site
526225012280 putative homotetramer interface [polypeptide binding]; other site
526225012281 glycerol binding site [chemical binding]; other site
526225012282 homodimer interface [polypeptide binding]; other site
526225012283 phosphoglucomutase; Validated; Region: PRK07564
526225012284 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
526225012285 active site
526225012286 substrate binding site [chemical binding]; other site
526225012287 metal binding site [ion binding]; metal-binding site
526225012288 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
526225012289 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
526225012290 FMN binding site [chemical binding]; other site
526225012291 dimer interface [polypeptide binding]; other site
526225012292 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435
526225012293 PGAP1-like protein; Region: PGAP1; pfam07819
526225012294 acyl-CoA esterase; Provisional; Region: PRK10673
526225012295 DEAD-like helicases superfamily; Region: DEXDc; smart00487
526225012296 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526225012297 ATP binding site [chemical binding]; other site
526225012298 putative Mg++ binding site [ion binding]; other site
526225012299 Helicase_C-like; Region: Helicase_C_4; pfam13871
526225012300 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
526225012301 thiamine phosphate binding site [chemical binding]; other site
526225012302 active site
526225012303 pyrophosphate binding site [ion binding]; other site
526225012304 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
526225012305 dimer interface [polypeptide binding]; other site
526225012306 substrate binding site [chemical binding]; other site
526225012307 ATP binding site [chemical binding]; other site
526225012308 DNA polymerase IV; Provisional; Region: PRK03348
526225012309 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
526225012310 active site
526225012311 DNA binding site [nucleotide binding]
526225012312 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
526225012313 Cation efflux family; Region: Cation_efflux; cl00316
526225012314 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526225012315 dimerization interface [polypeptide binding]; other site
526225012316 putative DNA binding site [nucleotide binding]; other site
526225012317 putative Zn2+ binding site [ion binding]; other site
526225012318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225012319 S-adenosylmethionine binding site [chemical binding]; other site
526225012320 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
526225012321 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
526225012322 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
526225012323 FAD binding pocket [chemical binding]; other site
526225012324 FAD binding motif [chemical binding]; other site
526225012325 phosphate binding motif [ion binding]; other site
526225012326 beta-alpha-beta structure motif; other site
526225012327 NAD binding pocket [chemical binding]; other site
526225012328 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526225012329 catalytic loop [active]
526225012330 iron binding site [ion binding]; other site
526225012331 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
526225012332 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
526225012333 putative di-iron ligands [ion binding]; other site
526225012334 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
526225012335 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
526225012336 Walker A motif; other site
526225012337 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306
526225012338 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203
526225012339 replicative DNA helicase; Region: DnaB; TIGR00665
526225012340 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
526225012341 ATP binding site [chemical binding]; other site
526225012342 Walker B motif; other site
526225012343 DNA binding loops [nucleotide binding]
526225012344 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
526225012345 homotrimer interaction site [polypeptide binding]; other site
526225012346 putative active site [active]
526225012347 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
526225012348 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
526225012349 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
526225012350 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
526225012351 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
526225012352 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
526225012353 dimer interface [polypeptide binding]; other site
526225012354 ssDNA binding site [nucleotide binding]; other site
526225012355 tetramer (dimer of dimers) interface [polypeptide binding]; other site
526225012356 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
526225012357 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
526225012358 endonuclease IV; Provisional; Region: PRK01060
526225012359 AP (apurinic/apyrimidinic) site pocket; other site
526225012360 DNA interaction; other site
526225012361 Metal-binding active site; metal-binding site
526225012362 Predicted integral membrane protein [Function unknown]; Region: COG5650
526225012363 Predicted integral membrane protein [Function unknown]; Region: COG5650
526225012364 Transglycosylase; Region: Transgly; pfam00912
526225012365 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
526225012366 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
526225012367 Predicted transcriptional regulators [Transcription]; Region: COG1695
526225012368 Transcriptional regulator PadR-like family; Region: PadR; pfam03551
526225012369 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
526225012370 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
526225012371 hypothetical protein; Validated; Region: PRK00228
526225012372 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
526225012373 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
526225012374 active site
526225012375 NTP binding site [chemical binding]; other site
526225012376 metal binding triad [ion binding]; metal-binding site
526225012377 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
526225012378 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
526225012379 Zn2+ binding site [ion binding]; other site
526225012380 Mg2+ binding site [ion binding]; other site
526225012381 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
526225012382 active site
526225012383 Ap6A binding site [chemical binding]; other site
526225012384 nudix motif; other site
526225012385 metal binding site [ion binding]; metal-binding site
526225012386 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
526225012387 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
526225012388 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
526225012389 Protein Kinases, catalytic domain; Region: PKc_like; cl09925
526225012390 active site
526225012391 ATP binding site [chemical binding]; other site
526225012392 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
526225012393 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
526225012394 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526225012395 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
526225012396 catalytic residues [active]
526225012397 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
526225012398 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
526225012399 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
526225012400 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
526225012401 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
526225012402 active site
526225012403 metal binding site [ion binding]; metal-binding site
526225012404 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
526225012405 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
526225012406 pyridoxal 5'-phosphate binding site [chemical binding]; other site
526225012407 homodimer interface [polypeptide binding]; other site
526225012408 catalytic residue [active]
526225012409 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
526225012410 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
526225012411 ATP-grasp domain; Region: ATP-grasp_4; cl17255
526225012412 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
526225012413 ParB-like nuclease domain; Region: ParBc; pfam02195
526225012414 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
526225012415 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
526225012416 P-loop; other site
526225012417 Magnesium ion binding site [ion binding]; other site
526225012418 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
526225012419 Magnesium ion binding site [ion binding]; other site
526225012420 rRNA small subunit methyltransferase G; Region: GidB; pfam02527
526225012421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526225012422 S-adenosylmethionine binding site [chemical binding]; other site
526225012423 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
526225012424 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
526225012425 G-X-X-G motif; other site
526225012426 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
526225012427 RxxxH motif; other site
526225012428 60Kd inner membrane protein; Region: 60KD_IMP; cl00489
526225012429 Haemolytic domain; Region: Haemolytic; pfam01809
526225012430 Ribonuclease P; Region: Ribonuclease_P; cl00457
526225012431 Ribosomal protein L34; Region: Ribosomal_L34; cl00370