-- dump date 20140619_085817 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type NP_285693.1 15799681 962112 190..273 1 NC_002655.2 involved in threonine biosynthesis; controls the expression of the thrLABC operon; thr operon leader peptide 273 thrL 962112 thrL Escherichia coli O157:H7 str. EDL933 thr operon leader peptide NP_285693.1 190 D 155864 CDS NP_285694.1 15799682 962110 354..2816 1 NC_002655.2 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homoserine dehydrogenase I 2816 thrA 962110 thrA Escherichia coli O157:H7 str. EDL933 bifunctional aspartokinase I/homoserine dehydrogenase I NP_285694.1 354 D 155864 CDS NP_285695.1 15799683 962111 2818..3750 1 NC_002655.2 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 3750 thrB 962111 thrB Escherichia coli O157:H7 str. EDL933 homoserine kinase NP_285695.1 2818 D 155864 CDS NP_285696.1 15799684 956660 3751..5037 1 NC_002655.2 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 5037 thrC 956660 thrC Escherichia coli O157:H7 str. EDL933 threonine synthase NP_285696.1 3751 D 155864 CDS NP_285697.1 15799685 956661 5251..5547 1 NC_002655.2 hypothetical protein 5547 956661 Z0005 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285697.1 5251 D 155864 CDS NP_285698.1 15799686 956662 complement(5700..6476) 1 NC_002655.2 hypothetical protein 6476 yaaA 956662 yaaA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285698.1 5700 R 155864 CDS NP_285699.1 15799687 956663 complement(6546..7976) 1 NC_002655.2 inner membrane transport protein 7976 yaaJ 956663 yaaJ Escherichia coli O157:H7 str. EDL933 inner membrane transport protein NP_285699.1 6546 R 155864 CDS NP_285700.1 15799688 956664 8255..9208 1 NC_002655.2 Maintains the balance of metabolites in the pentose-phosphate pathway; transaldolase B 9208 talB 956664 talB Escherichia coli O157:H7 str. EDL933 transaldolase B NP_285700.1 8255 D 155864 CDS NP_285701.1 15799689 956666 9323..9910 1 NC_002655.2 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MogA 9910 mogA 956666 mogA Escherichia coli O157:H7 str. EDL933 molybdenum cofactor biosynthesis protein MogA NP_285701.1 9323 D 155864 CDS NP_285702.1 15799690 956668 complement(9945..10511) 1 NC_002655.2 hypothetical protein 10511 yaaH 956668 yaaH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285702.1 9945 R 155864 CDS NP_285703.1 15799691 956669 complement(10660..11373) 1 NC_002655.2 hypothetical protein 11373 956669 Z0011 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285703.1 10660 R 155864 CDS NP_285705.1 15799693 956671 complement(11399..11803) 1 NC_002655.2 hypothetical protein 11803 yaaI 956671 yaaI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285705.1 11399 R 155864 CDS NP_285706.1 15799694 956673 12180..14096 1 NC_002655.2 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 14096 dnaK 956673 dnaK Escherichia coli O157:H7 str. EDL933 molecular chaperone DnaK NP_285706.1 12180 D 155864 CDS NP_285707.1 15799695 956674 14185..15315 1 NC_002655.2 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 15315 dnaJ 956674 dnaJ Escherichia coli O157:H7 str. EDL933 molecular chaperone DnaJ NP_285707.1 14185 D 155864 CDS NP_285708.1 15799696 956675 complement(15419..15628) 1 NC_002655.2 Gef protein 15628 gef 956675 gef Escherichia coli O157:H7 str. EDL933 Gef protein NP_285708.1 15419 R 155864 CDS NP_285709.1 15799697 956676 16157..17323 1 NC_002655.2 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 17323 nhaA 956676 nhaA Escherichia coli O157:H7 str. EDL933 pH-dependent sodium/proton antiporter NP_285709.1 16157 D 155864 CDS NP_285710.1 15799698 956677 17383..18288 1 NC_002655.2 Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC; transcriptional activator NhaR 18288 nhaR 956677 nhaR Escherichia coli O157:H7 str. EDL933 transcriptional activator NhaR NP_285710.1 17383 D 155864 CDS NP_285711.1 15799699 956678 complement(18326..18949) 1 NC_002655.2 No significant matches; hypothetical protein 18949 956678 Z0020 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285711.1 18326 R 155864 CDS NP_285712.1 15799700 956679 complement(18960..19286) 1 NC_002655.2 No significant matches; hypothetical protein 19286 956679 Z0021 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285712.1 18960 R 155864 CDS NP_285713.1 15799701 956680 complement(19299..21749) 1 NC_002655.2 usher protein 21749 956680 Z0022 Escherichia coli O157:H7 str. EDL933 usher protein NP_285713.1 19299 R 155864 CDS NP_285714.1 15799702 956681 complement(21762..22445) 1 NC_002655.2 chaperone protein 22445 956681 Z0023 Escherichia coli O157:H7 str. EDL933 chaperone protein NP_285714.1 21762 R 155864 CDS NP_285715.1 15799703 956683 complement(22495..23028) 1 NC_002655.2 type-1 fimbrial protein 23028 956683 Z0024 Escherichia coli O157:H7 str. EDL933 type-1 fimbrial protein NP_285715.1 22495 R 155864 CDS NP_285716.1 15799704 956684 complement(23330..24751) 1 NC_002655.2 No significant matches; hypothetical protein 24751 956684 Z0025 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285716.1 23330 R 155864 CDS NP_285717.1 15799705 956688 complement(25221..25484) 1 NC_002655.2 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 25484 rpsT 956688 rpsT Escherichia coli O157:H7 str. EDL933 30S ribosomal protein S20 NP_285717.1 25221 R 155864 CDS NP_285718.1 15799706 956689 25587..25811 1 NC_002655.2 hypothetical protein 25811 956689 Z0028 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285718.1 25587 D 155864 CDS NP_285719.1 15799707 956690 25819..26760 1 NC_002655.2 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 26760 ribF 956690 ribF Escherichia coli O157:H7 str. EDL933 bifunctional riboflavin kinase/FMN adenylyltransferase NP_285719.1 25819 D 155864 CDS NP_285720.1 15799708 956691 26803..29619 1 NC_002655.2 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 29619 ileS 956691 ileS Escherichia coli O157:H7 str. EDL933 isoleucyl-tRNA synthetase NP_285720.1 26803 D 155864 CDS NP_285721.1 15799709 956692 29619..30113 1 NC_002655.2 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 30113 lspA 956692 lspA Escherichia coli O157:H7 str. EDL933 lipoprotein signal peptidase NP_285721.1 29619 D 155864 CDS NP_285722.1 15799710 956693 30201..30650 1 NC_002655.2 peptidyl-prolyl cis- trans isomerase 30650 slpA 956693 slpA Escherichia coli O157:H7 str. EDL933 peptidyl-prolyl cis- trans isomerase NP_285722.1 30201 D 155864 CDS NP_285723.1 15799711 956694 30652..31602 1 NC_002655.2 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 31602 ispH 956694 ispH Escherichia coli O157:H7 str. EDL933 4-hydroxy-3-methylbut-2-enyl diphosphate reductase NP_285723.1 30652 D 155864 CDS NP_285724.1 15799712 956696 31668..32582 1 NC_002655.2 catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides; ribonucleoside hydrolase RihC 32582 yaaF 956696 yaaF Escherichia coli O157:H7 str. EDL933 ribonucleoside hydrolase RihC NP_285724.1 31668 D 155864 CDS NP_285725.1 15799713 956697 32749..33570 1 NC_002655.2 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 33570 dapB 956697 dapB Escherichia coli O157:H7 str. EDL933 dihydrodipicolinate reductase NP_285725.1 32749 D 155864 CDS NP_285726.1 15799714 956698 34026..35174 1 NC_002655.2 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 35174 carA 956698 carA Escherichia coli O157:H7 str. EDL933 carbamoyl phosphate synthase small subunit NP_285726.1 34026 D 155864 CDS NP_285727.1 15799715 956699 35192..38413 1 NC_002655.2 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 38413 carB 956699 carB Escherichia coli O157:H7 str. EDL933 carbamoyl phosphate synthase large subunit NP_285727.1 35192 D 155864 CDS NP_285728.1 15799716 956700 complement(38421..38639) 1 NC_002655.2 No significant matches; hypothetical protein 38639 956700 Z0039 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285728.1 38421 R 155864 CDS NP_285729.2 161367661 956701 38674..39069 1 NC_002655.2 regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons; DNA-binding transcriptional activator CaiF 39069 956701 Z0040 Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional activator CaiF NP_285729.2 38674 D 155864 CDS NP_285730.1 15799718 956703 complement(39188..39799) 1 NC_002655.2 involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities; carnitine operon protein CaiE 39799 caiE 956703 caiE Escherichia coli O157:H7 str. EDL933 carnitine operon protein CaiE NP_285730.1 39188 R 155864 CDS NP_285731.2 228979049 956704 complement(39784..40569) 1 NC_002655.2 catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA; carnitinyl-CoA dehydratase 40569 caiD 956704 caiD Escherichia coli O157:H7 str. EDL933 carnitinyl-CoA dehydratase NP_285731.2 39784 R 155864 CDS NP_285732.1 15799720 956705 complement(40678..42246) 1 NC_002655.2 crotonobetaine/carnitine-CoA ligase 42246 caiC 956705 caiC Escherichia coli O157:H7 str. EDL933 crotonobetaine/carnitine-CoA ligase NP_285732.1 40678 R 155864 CDS NP_285733.1 15799721 956706 complement(42305..43522) 1 NC_002655.2 catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine; crotonobetainyl-CoA:carnitine CoA-transferase 43522 caiB 956706 caiB Escherichia coli O157:H7 str. EDL933 crotonobetainyl-CoA:carnitine CoA-transferase NP_285733.1 42305 R 155864 CDS NP_285734.1 15799722 956708 complement(43651..44793) 1 NC_002655.2 catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA; crotonobetainyl-CoA dehydrogenase 44793 caiA 956708 caiA Escherichia coli O157:H7 str. EDL933 crotonobetainyl-CoA dehydrogenase NP_285734.1 43651 R 155864 CDS NP_285735.1 15799723 956709 complement(44824..46338) 1 NC_002655.2 catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism; L-carnitine/gamma-butyrobetaine antiporter 46338 caiT 956709 caiT Escherichia coli O157:H7 str. EDL933 L-carnitine/gamma-butyrobetaine antiporter NP_285735.1 44824 R 155864 CDS NP_285736.2 161367660 956710 46817..47587 1 NC_002655.2 required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase; electron transfer flavoprotein FixA 47587 fixA 956710 fixA Escherichia coli O157:H7 str. EDL933 electron transfer flavoprotein FixA NP_285736.2 46817 D 155864 CDS NP_285737.1 15799725 956711 47602..48543 1 NC_002655.2 involved in electron transfer during carnitine metabolism; electron transfer flavoprotein FixB 48543 fixB 956711 fixB Escherichia coli O157:H7 str. EDL933 electron transfer flavoprotein FixB NP_285737.1 47602 D 155864 CDS NP_285738.1 15799726 956714 48594..49880 1 NC_002655.2 FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction; oxidoreductase FixC 49880 fixC 956714 fixC Escherichia coli O157:H7 str. EDL933 oxidoreductase FixC NP_285738.1 48594 D 155864 CDS NP_285739.1 15799727 956715 49877..50164 1 NC_002655.2 ferredoxin 50164 fixX 956715 fixX Escherichia coli O157:H7 str. EDL933 ferredoxin NP_285739.1 49877 D 155864 CDS NP_285740.1 15799728 956716 50222..51553 1 NC_002655.2 transporter 51553 yaaU 956716 yaaU Escherichia coli O157:H7 str. EDL933 transporter NP_285740.1 50222 D 155864 CDS NP_285741.1 15799729 956717 51661..52191 1 NC_002655.2 Required for full activity of KefC, a potassium-proton antiporter; glutathione-regulated potassium-efflux system ancillary protein KefF 52191 yabF 956717 yabF Escherichia coli O157:H7 str. EDL933 glutathione-regulated potassium-efflux system ancillary protein KefF NP_285741.1 51661 D 155864 CDS NP_285742.1 15799730 956719 52184..54046 1 NC_002655.2 transport system that facilitates potassium-efflux; glutathione-regulated potassium-efflux system protein KefC 54046 kefC 956719 kefC Escherichia coli O157:H7 str. EDL933 glutathione-regulated potassium-efflux system protein KefC NP_285742.1 52184 D 155864 CDS NP_285743.1 15799731 956721 54238..54717 1 NC_002655.2 catalyzes the reduction of dihydrofolate to tetrahydrofolate; dihydrofolate reductase 54717 folA 956721 folA Escherichia coli O157:H7 str. EDL933 dihydrofolate reductase NP_285743.1 54238 D 155864 CDS NP_285744.1 15799732 956723 54803..55036 1 NC_002655.2 antitoxin of gyrase inhibiting toxin-antitoxin system 55036 956723 Z0056 Escherichia coli O157:H7 str. EDL933 antitoxin of gyrase inhibiting toxin-antitoxin system NP_285744.1 54803 D 155864 CDS NP_285745.1 15799733 956724 55039..55353 1 NC_002655.2 toxin of gyrase inhibiting toxin-antitoxin system 55353 956724 Z0057 Escherichia coli O157:H7 str. EDL933 toxin of gyrase inhibiting toxin-antitoxin system NP_285745.1 55039 D 155864 CDS NP_285746.1 15799734 956725 complement(55350..56198) 1 NC_002655.2 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase 56198 apaH 956725 apaH Escherichia coli O157:H7 str. EDL933 diadenosine tetraphosphatase NP_285746.1 55350 R 155864 CDS NP_285747.1 15799735 956726 complement(56205..56582) 1 NC_002655.2 protein associated with Co2+ and Mg2+ efflux; ApaG protein 56582 apaG 956726 apaG Escherichia coli O157:H7 str. EDL933 ApaG protein NP_285747.1 56205 R 155864 CDS NP_285748.1 15799736 956727 complement(56585..57406) 1 NC_002655.2 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 57406 ksgA 956727 ksgA Escherichia coli O157:H7 str. EDL933 dimethyladenosine transferase NP_285748.1 56585 R 155864 CDS NP_285749.1 15799737 956728 complement(57403..58392) 1 NC_002655.2 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase 58392 pdxA 956728 pdxA Escherichia coli O157:H7 str. EDL933 4-hydroxythreonine-4-phosphate dehydrogenase NP_285749.1 57403 R 155864 CDS NP_285750.1 15799738 956729 complement(58392..59678) 1 NC_002655.2 Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB; peptidyl-prolyl cis-trans isomerase SurA 59678 surA 956729 surA Escherichia coli O157:H7 str. EDL933 peptidyl-prolyl cis-trans isomerase SurA NP_285750.1 58392 R 155864 CDS NP_285751.1 15799739 956730 complement(59731..62085) 1 NC_002655.2 determines N-hexane tolerance and is involved in outer membrane permeability; organic solvent tolerance protein 62085 imp 956730 imp Escherichia coli O157:H7 str. EDL933 organic solvent tolerance protein NP_285751.1 59731 R 155864 CDS NP_285752.1 15799740 956731 62340..63155 1 NC_002655.2 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; molecular chaperone DnaJ 63155 djlA 956731 djlA Escherichia coli O157:H7 str. EDL933 molecular chaperone DnaJ NP_285752.1 62340 D 155864 CDS NP_285753.1 15799741 956733 63450..64202 1 NC_002655.2 hypothetical protein 64202 956733 Z0065 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285753.1 63450 D 155864 CDS NP_285754.1 15799742 956734 complement(64620..65279) 1 NC_002655.2 catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs; 23S rRNA/tRNA pseudouridine synthase A 65279 yabO 956734 yabO Escherichia coli O157:H7 str. EDL933 23S rRNA/tRNA pseudouridine synthase A NP_285754.1 64620 R 155864 CDS NP_285755.1 15799743 956735 complement(65291..68197) 1 NC_002655.2 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA; ATP-dependent helicase HepA 68197 956735 Z0067 Escherichia coli O157:H7 str. EDL933 ATP-dependent helicase HepA NP_285755.1 65291 R 155864 CDS NP_285756.1 15799744 956736 complement(68361..70712) 1 NC_002655.2 Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C; DNA polymerase II 70712 polB 956736 polB Escherichia coli O157:H7 str. EDL933 DNA polymerase II NP_285756.1 68361 R 155864 CDS NP_285757.1 15799745 956737 complement(70787..71482) 1 NC_002655.2 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 71482 araD 956737 araD Escherichia coli O157:H7 str. EDL933 L-ribulose-5-phosphate 4-epimerase NP_285757.1 70787 R 155864 CDS NP_285758.1 15799746 956742 complement(71682..73184) 1 NC_002655.2 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism; L-arabinose isomerase 73184 araA 956742 araA Escherichia coli O157:H7 str. EDL933 L-arabinose isomerase NP_285758.1 71682 R 155864 CDS NP_285759.1 15799747 956743 complement(73195..74895) 1 NC_002655.2 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate; ribulokinase 74895 araB 956743 araB Escherichia coli O157:H7 str. EDL933 ribulokinase NP_285759.1 73195 R 155864 CDS NP_285760.1 15799748 956744 75234..76112 1 NC_002655.2 positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose; DNA-binding transcriptional regulator AraC 76112 araC 956744 araC Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator AraC NP_285760.1 75234 D 155864 CDS NP_285761.1 15799749 956745 76198..76962 1 NC_002655.2 hypothetical protein 76962 yabI 956745 yabI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285761.1 76198 D 155864 CDS NP_285762.1 15799750 956746 complement(77049..77747) 1 NC_002655.2 with TbpA and ThiP is part of the thiamine and TPP transport system; thiamine transporter ATP-binding subunit 77747 thiQ 956746 thiQ Escherichia coli O157:H7 str. EDL933 thiamine transporter ATP-binding subunit NP_285762.1 77049 R 155864 CDS NP_285763.1 15799751 956747 complement(77731..79341) 1 NC_002655.2 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine transporter membrane protein 79341 thiP 956747 thiP Escherichia coli O157:H7 str. EDL933 thiamine transporter membrane protein NP_285763.1 77731 R 155864 CDS NP_285764.1 15799752 956748 complement(79317..80300) 1 NC_002655.2 part of the thiamine and TPP transport system tbpA-thiPQ; thiamine transporter substrate binding subunit 80300 tbpA 956748 tbpA Escherichia coli O157:H7 str. EDL933 thiamine transporter substrate binding subunit NP_285764.1 79317 R 155864 CDS NP_285765.1 15799753 956752 80672..81241 1 NC_002655.2 hypothetical protein 81241 956752 Z0078 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285765.1 80672 D 155864 CDS NP_285766.1 15799754 956753 complement(81470..83128) 1 NC_002655.2 activates sgrS under glucose-phosphate stress conditions; transcriptional regulator SgrR 83128 yabN 956753 yabN Escherichia coli O157:H7 str. EDL933 transcriptional regulator SgrR NP_285766.1 81470 R 155864 CDS NP_285767.1 15799755 956754 complement(83456..84061) 1 NC_002655.2 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 84061 leuD 956754 leuD Escherichia coli O157:H7 str. EDL933 isopropylmalate isomerase small subunit NP_285767.1 83456 R 155864 CDS NP_285768.1 15799756 956755 complement(84072..85472) 1 NC_002655.2 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 85472 leuC 956755 leuC Escherichia coli O157:H7 str. EDL933 isopropylmalate isomerase large subunit NP_285768.1 84072 R 155864 CDS NP_285769.2 161367659 956756 complement(85475..86566) 1 NC_002655.2 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 86566 leuB 956756 leuB Escherichia coli O157:H7 str. EDL933 3-isopropylmalate dehydrogenase NP_285769.2 85475 R 155864 CDS NP_285770.1 15799758 956757 complement(86566..88137) 1 NC_002655.2 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase 88137 leuA 956757 leuA Escherichia coli O157:H7 str. EDL933 2-isopropylmalate synthase NP_285770.1 86566 R 155864 CDS NP_285771.1 15799759 956758 complement(88230..88316) 1 NC_002655.2 involved in attenuation control of the leuABCD operon in leucine biosynthesis; leu operon leader peptide 88316 leuL 956758 leuL Escherichia coli O157:H7 str. EDL933 leu operon leader peptide NP_285771.1 88230 R 155864 CDS NP_285772.1 15799760 956759 88956..89918 1 NC_002655.2 activator for leuABCD operon; member of LysR family of transcriptional activators; leucine transcriptional activator 89918 leuO 956759 leuO Escherichia coli O157:H7 str. EDL933 leucine transcriptional activator NP_285772.1 88956 D 155864 CDS NP_285773.2 161367658 956760 90236..91960 1 NC_002655.2 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; acetolactate synthase 3 catalytic subunit 91960 ilvI 956760 ilvI Escherichia coli O157:H7 str. EDL933 acetolactate synthase 3 catalytic subunit NP_285773.2 90236 D 155864 CDS NP_285774.1 15799762 956761 91963..92454 1 NC_002655.2 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 92454 ilvH 956761 ilvH Escherichia coli O157:H7 str. EDL933 acetolactate synthase 3 regulatory subunit NP_285774.1 91963 D 155864 CDS NP_285776.1 15799764 956764 92634..93638 1 NC_002655.2 binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism; DNA-binding transcriptional regulator FruR 93638 fruR 956764 fruR Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator FruR NP_285776.1 92634 D 155864 CDS NP_285777.1 15799765 956765 94240..94698 1 NC_002655.2 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 94698 yabB 956765 yabB Escherichia coli O157:H7 str. EDL933 cell division protein MraZ NP_285777.1 94240 D 155864 CDS NP_285778.1 15799766 956766 94700..95641 1 NC_002655.2 S-adenosyl-methyltransferase MraW 95641 mraW 956766 mraW Escherichia coli O157:H7 str. EDL933 S-adenosyl-methyltransferase MraW NP_285778.1 94700 D 155864 CDS NP_285779.1 15799767 956768 95638..96003 1 NC_002655.2 membrane bound cell division protein at septum containing leucine zipper motif; cell division protein FtsL 96003 ftsL 956768 ftsL Escherichia coli O157:H7 str. EDL933 cell division protein FtsL NP_285779.1 95638 D 155864 CDS NP_285780.1 15799768 956770 96019..97785 1 NC_002655.2 septum formation; penicillin-binding protein 3; peptidoglycan synthetase 97785 ftsI 956770 ftsI Escherichia coli O157:H7 str. EDL933 septum formation; penicillin-binding protein 3; peptidoglycan synthetase NP_285780.1 96019 D 155864 CDS NP_285781.1 15799769 956771 97772..99259 1 NC_002655.2 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 99259 murE 956771 murE Escherichia coli O157:H7 str. EDL933 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase NP_285781.1 97772 D 155864 CDS NP_285782.1 15799770 956772 99256..100614 1 NC_002655.2 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 100614 murF 956772 murF Escherichia coli O157:H7 str. EDL933 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase NP_285782.1 99256 D 155864 CDS NP_285783.1 15799771 956773 100608..101690 1 NC_002655.2 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 101690 mraY 956773 mraY Escherichia coli O157:H7 str. EDL933 phospho-N-acetylmuramoyl-pentapeptide- transferase NP_285783.1 100608 D 155864 CDS NP_285784.1 15799772 956774 101693..103009 1 NC_002655.2 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 103009 murD 956774 murD Escherichia coli O157:H7 str. EDL933 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase NP_285784.1 101693 D 155864 CDS NP_285785.1 15799773 956775 103009..104253 1 NC_002655.2 integral membrane protein involved in stabilizing FstZ ring during cell division; cell division protein FtsW 104253 ftsW 956775 ftsW Escherichia coli O157:H7 str. EDL933 cell division protein FtsW NP_285785.1 103009 D 155864 CDS NP_285786.1 15799774 956776 104250..105317 1 NC_002655.2 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 105317 murG 956776 murG Escherichia coli O157:H7 str. EDL933 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase NP_285786.1 104250 D 155864 CDS NP_285787.1 15799775 956777 105371..106846 1 NC_002655.2 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 106846 murC 956777 murC Escherichia coli O157:H7 str. EDL933 UDP-N-acetylmuramate--L-alanine ligase NP_285787.1 105371 D 155864 CDS NP_285788.1 15799776 956778 106839..107759 1 NC_002655.2 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 107759 ddl 956778 ddl Escherichia coli O157:H7 str. EDL933 D-alanine--D-alanine ligase NP_285788.1 106839 D 155864 CDS NP_285789.1 15799777 956781 107761..108591 1 NC_002655.2 involved in septum formation; cell division protein FtsQ 108591 ftsQ 956781 ftsQ Escherichia coli O157:H7 str. EDL933 cell division protein FtsQ NP_285789.1 107761 D 155864 CDS NP_285790.1 15799778 956782 108588..109850 1 NC_002655.2 ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane; cell division protein FtsA 109850 ftsA 956782 ftsA Escherichia coli O157:H7 str. EDL933 cell division protein FtsA NP_285790.1 108588 D 155864 CDS NP_285791.1 15799779 956784 109911..111062 1 NC_002655.2 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 111062 ftsZ 956784 ftsZ Escherichia coli O157:H7 str. EDL933 cell division protein FtsZ NP_285791.1 109911 D 155864 CDS NP_285792.1 15799780 956787 111163..112080 1 NC_002655.2 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 112080 lpxC 956787 lpxC Escherichia coli O157:H7 str. EDL933 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase NP_285792.1 111163 D 155864 CDS NP_285793.2 161367657 956788 112311..112823 1 NC_002655.2 secM translational pause allows for the initiation of secA translation; SecA regulator SecM 112823 yacA 956788 yacA Escherichia coli O157:H7 str. EDL933 SecA regulator SecM NP_285793.2 112311 D 155864 CDS NP_285794.1 15799782 956789 112885..115590 1 NC_002655.2 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 115590 secA 956789 secA Escherichia coli O157:H7 str. EDL933 preprotein translocase subunit SecA NP_285794.1 112885 D 155864 CDS NP_285795.1 15799783 956790 115650..116048 1 NC_002655.2 nucleoside triphosphate pyrophosphohydrolase 116048 mutT 956790 mutT Escherichia coli O157:H7 str. EDL933 nucleoside triphosphate pyrophosphohydrolase NP_285795.1 115650 D 155864 CDS NP_285796.1 15799784 956791 complement(116054..116188) 1 NC_002655.2 hypothetical protein 116188 956791 Z0110 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285796.1 116054 R 155864 CDS NP_285797.1 15799785 956792 complement(116139..116336) 1 NC_002655.2 zinc-binding protein 116336 yacG 956792 yacG Escherichia coli O157:H7 str. EDL933 zinc-binding protein NP_285797.1 116139 R 155864 CDS NP_285798.1 15799786 956793 complement(116346..117089) 1 NC_002655.2 hypothetical protein 117089 yacF 956793 yacF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285798.1 116346 R 155864 CDS NP_285799.1 15799787 956794 complement(117089..117709) 1 NC_002655.2 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 117709 coaE 956794 coaE Escherichia coli O157:H7 str. EDL933 dephospho-CoA kinase NP_285799.1 117089 R 155864 CDS NP_285800.1 15799788 956795 117934..118977 1 NC_002655.2 catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate; guanosine 5'-monophosphate oxidoreductase 118977 guaC 956795 guaC Escherichia coli O157:H7 str. EDL933 guanosine 5'-monophosphate oxidoreductase NP_285800.1 117934 D 155864 CDS NP_285801.1 15799789 956796 complement(118897..119004) 1 NC_002655.2 hypothetical protein 119004 956796 Z0115 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285801.1 118897 R 155864 CDS NP_285802.1 15799790 956797 complement(119012..120214) 1 NC_002655.2 type IV pilin biogenesis protein 120214 hofC 956797 hofC Escherichia coli O157:H7 str. EDL933 type IV pilin biogenesis protein NP_285802.1 119012 R 155864 CDS NP_285803.1 15799791 956799 complement(120204..121589) 1 NC_002655.2 hypothetical protein 121589 hofB 956799 hofB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285803.1 120204 R 155864 CDS NP_285804.1 15799792 956800 complement(121599..122039) 1 NC_002655.2 major pilin subunit 122039 ppdD 956800 ppdD Escherichia coli O157:H7 str. EDL933 major pilin subunit NP_285804.1 121599 R 155864 CDS NP_285805.1 15799793 956801 complement(122242..123135) 1 NC_002655.2 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; quinolinate phosphoribosyltransferase 123135 nadC 956801 nadC Escherichia coli O157:H7 str. EDL933 quinolinate phosphoribosyltransferase NP_285805.1 122242 R 155864 CDS NP_285806.1 15799794 956802 123223..123774 1 NC_002655.2 N-acetyl-anhydromuranmyl-L-alanine amidase 123774 ampD 956802 ampD Escherichia coli O157:H7 str. EDL933 N-acetyl-anhydromuranmyl-L-alanine amidase NP_285806.1 123223 D 155864 CDS NP_285807.1 15799795 956804 123771..124625 1 NC_002655.2 involved in regulation of beta-lactamase; signaling protein; regulatory protein AmpE 124625 ampE 956804 ampE Escherichia coli O157:H7 str. EDL933 regulatory protein AmpE NP_285807.1 123771 D 155864 CDS NP_285808.1 15799796 956805 complement(124668..126041) 1 NC_002655.2 aromatic amino acid transporter 126041 aroP 956805 aroP Escherichia coli O157:H7 str. EDL933 aromatic amino acid transporter NP_285808.1 124668 R 155864 CDS NP_285809.1 15799797 956808 126582..127346 1 NC_002655.2 activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex; transcriptional regulator PdhR 127346 pdhR 956808 pdhR Escherichia coli O157:H7 str. EDL933 transcriptional regulator PdhR NP_285809.1 126582 D 155864 CDS NP_285810.1 15799798 956809 127507..130170 1 NC_002655.2 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 130170 aceE 956809 aceE Escherichia coli O157:H7 str. EDL933 pyruvate dehydrogenase subunit E1 NP_285810.1 127507 D 155864 CDS NP_285811.1 15799799 956812 130185..132077 1 NC_002655.2 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase 132077 aceF 956812 aceF Escherichia coli O157:H7 str. EDL933 dihydrolipoamide acetyltransferase NP_285811.1 130185 D 155864 CDS NP_285812.1 15799800 956813 132285..133709 1 NC_002655.2 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 133709 lpdA 956813 lpdA Escherichia coli O157:H7 str. EDL933 dihydrolipoamide dehydrogenase NP_285812.1 132285 D 155864 CDS NP_285813.1 15799801 956814 complement(133780..135633) 1 NC_002655.2 hypothetical protein 135633 yacH 956814 yacH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285813.1 133780 R 155864 CDS NP_285814.1 15799802 956815 135988..138585 1 NC_002655.2 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 138585 acnB 956815 acnB Escherichia coli O157:H7 str. EDL933 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase NP_285814.1 135988 D 155864 CDS NP_285815.2 161367656 956816 138761..139123 1 NC_002655.2 hypothetical protein 139123 yacL 956816 yacL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285815.2 138761 D 155864 CDS NP_285816.1 15799804 956820 complement(139161..139955) 1 NC_002655.2 S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine; S-adenosylmethionine decarboxylase 139955 speD 956820 speD Escherichia coli O157:H7 str. EDL933 S-adenosylmethionine decarboxylase NP_285816.1 139161 R 155864 CDS NP_285817.1 15799805 956821 complement(139971..140837) 1 NC_002655.2 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 140837 speE 956821 speE Escherichia coli O157:H7 str. EDL933 spermidine synthase NP_285817.1 139971 R 155864 CDS NP_285818.1 15799806 956822 complement(140943..141413) 1 NC_002655.2 hypothetical protein 141413 yacC 956822 yacC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285818.1 140943 R 155864 CDS NP_285819.1 15799807 956823 141456..143006 1 NC_002655.2 laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification; multicopper oxidase 143006 yacK 956823 yacK Escherichia coli O157:H7 str. EDL933 multicopper oxidase NP_285819.1 141456 D 155864 CDS NP_285820.1 15799808 956827 complement(143208..145598) 1 NC_002655.2 glucose dehydrogenase 145598 gcd 956827 gcd Escherichia coli O157:H7 str. EDL933 glucose dehydrogenase NP_285820.1 143208 R 155864 CDS NP_285821.2 161367655 956828 145804..146340 1 NC_002655.2 Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively; hypoxanthine-guanine phosphoribosyltransferase 146340 hpt 956828 hpt Escherichia coli O157:H7 str. EDL933 hypoxanthine-guanine phosphoribosyltransferase NP_285821.2 145804 D 155864 CDS NP_285822.1 15799810 956830 complement(146381..147043) 1 NC_002655.2 catalyzes the interconversion of bicarbonate and carbon dioxide; carbonic anhydrase 147043 yadF 956830 yadF Escherichia coli O157:H7 str. EDL933 carbonic anhydrase NP_285822.1 146381 R 155864 CDS NP_285823.1 15799811 956832 147152..148078 1 NC_002655.2 ABC transporter ATP-binding protein 148078 yadG 956832 yadG Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_285823.1 147152 D 155864 CDS NP_285824.1 15799812 956833 148075..148845 1 NC_002655.2 hypothetical protein 148845 yadH 956833 yadH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285824.1 148075 D 155864 CDS NP_285825.1 15799813 956834 148950..149390 1 NC_002655.2 PTS enzyme II B component 149390 yadI 956834 yadI Escherichia coli O157:H7 str. EDL933 PTS enzyme II B component NP_285825.1 148950 D 155864 CDS NP_285826.1 15799814 956835 149454..150683 1 NC_002655.2 hypothetical protein 150683 yadE 956835 yadE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285826.1 149454 D 155864 CDS NP_285827.1 15799815 956836 complement(150687..151067) 1 NC_002655.2 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 151067 panD 956836 panD Escherichia coli O157:H7 str. EDL933 aspartate alpha-decarboxylase NP_285827.1 150687 R 155864 CDS NP_285828.1 15799816 956837 151341..152237 1 NC_002655.2 hypothetical protein 152237 yadD 956837 yadD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285828.1 151341 D 155864 CDS NP_285829.1 15799817 956839 complement(152536..153387) 1 NC_002655.2 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 153387 panC 956839 panC Escherichia coli O157:H7 str. EDL933 pantoate--beta-alanine ligase NP_285829.1 152536 R 155864 CDS NP_285830.1 15799818 956841 complement(153399..154193) 1 NC_002655.2 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 154193 panB 956841 panB Escherichia coli O157:H7 str. EDL933 3-methyl-2-oxobutanoate hydroxymethyltransferase NP_285830.1 153399 R 155864 CDS NP_285831.1 15799819 956842 complement(154328..155437) 1 NC_002655.2 fimbrial protein 155437 yadC 956842 yadC Escherichia coli O157:H7 str. EDL933 fimbrial protein NP_285831.1 154328 R 155864 CDS NP_285832.1 15799820 956843 complement(155449..156039) 1 NC_002655.2 fimbrial protein 156039 yadK 956843 yadK Escherichia coli O157:H7 str. EDL933 fimbrial protein NP_285832.1 155449 R 155864 CDS NP_285833.1 15799821 956844 complement(156060..156665) 1 NC_002655.2 fimbrial protein 156665 yadL 956844 yadL Escherichia coli O157:H7 str. EDL933 fimbrial protein NP_285833.1 156060 R 155864 CDS NP_285834.1 15799822 956845 complement(156680..157240) 1 NC_002655.2 fimbrial protein 157240 yadM 956845 yadM Escherichia coli O157:H7 str. EDL933 fimbrial protein NP_285834.1 156680 R 155864 CDS NP_285835.2 161367654 956847 complement(157242..159842) 1 NC_002655.2 similar to the fimbrial usher protein PapC; outer membrane usher protein 159842 htrE 956847 htrE Escherichia coli O157:H7 str. EDL933 outer membrane usher protein NP_285835.2 157242 R 155864 CDS NP_285836.1 15799824 956849 complement(159884..160615) 1 NC_002655.2 chaperone protein EcpD 160615 ecpD 956849 ecpD Escherichia coli O157:H7 str. EDL933 chaperone protein EcpD NP_285836.1 159884 R 155864 CDS NP_285837.1 15799825 956850 complement(160696..161301) 1 NC_002655.2 fimbrial protein 161301 yadN 956850 yadN Escherichia coli O157:H7 str. EDL933 fimbrial protein NP_285837.1 160696 R 155864 CDS NP_285838.1 15799826 956852 complement(161573..162055) 1 NC_002655.2 catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 162055 folK 956852 folK Escherichia coli O157:H7 str. EDL933 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase NP_285838.1 161573 R 155864 CDS NP_285839.2 161367653 956853 complement(162052..163470) 1 NC_002655.2 Polymerase that creates the 3' poly(A) tail found in some mRNA's; poly(A) polymerase 163470 pcnB 956853 pcnB Escherichia coli O157:H7 str. EDL933 poly(A) polymerase NP_285839.2 162052 R 155864 CDS NP_285840.2 161367652 956855 complement(163509..164405) 1 NC_002655.2 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu; glutamyl-Q tRNA(Asp) synthetase 164405 yadB 956855 yadB Escherichia coli O157:H7 str. EDL933 glutamyl-Q tRNA(Asp) synthetase NP_285840.2 163509 R 155864 CDS NP_285841.1 15799829 956857 complement(164472..164927) 1 NC_002655.2 RNA polymerase-binding transcription factor 164927 dksA 956857 dksA Escherichia coli O157:H7 str. EDL933 RNA polymerase-binding transcription factor NP_285841.1 164472 R 155864 CDS NP_285842.1 15799830 956859 complement(165105..165809) 1 NC_002655.2 Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A 165809 sfsA 956859 sfsA Escherichia coli O157:H7 str. EDL933 sugar fermentation stimulation protein A NP_285842.1 165105 R 155864 CDS NP_285843.1 15799831 956861 complement(165824..166363) 1 NC_002655.2 2'-5' RNA ligase 166363 yadP 956861 yadP Escherichia coli O157:H7 str. EDL933 2'-5' RNA ligase NP_285843.1 165824 R 155864 CDS NP_285844.1 15799832 956862 166383..168857 1 NC_002655.2 similar in sequence to the ATP-dependent RNA helicase HrpA; ATP-dependent RNA helicase HrpB 168857 hrpB 956862 hrpB Escherichia coli O157:H7 str. EDL933 ATP-dependent RNA helicase HrpB NP_285844.1 166383 D 155864 CDS NP_285845.1 15799833 956863 169053..171587 1 NC_002655.2 bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell; penicillin-binding protein 1b 171587 mrcB 956863 mrcB Escherichia coli O157:H7 str. EDL933 penicillin-binding protein 1b NP_285845.1 169053 D 155864 CDS NP_285846.1 15799834 956865 171807..174050 1 NC_002655.2 involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein; ferrichrome outer membrane transporter 174050 fhuA 956865 fhuA Escherichia coli O157:H7 str. EDL933 ferrichrome outer membrane transporter NP_285846.1 171807 D 155864 CDS NP_285847.1 15799835 956866 174101..174898 1 NC_002655.2 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; iron-hydroxamate transporter ATP-binding subunit 174898 fhuC 956866 fhuC Escherichia coli O157:H7 str. EDL933 iron-hydroxamate transporter ATP-binding subunit NP_285847.1 174101 D 155864 CDS NP_285848.1 15799836 956867 174898..175788 1 NC_002655.2 Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores; iron-hydroxamate transporter substrate-binding subunit 175788 fhuD 956867 fhuD Escherichia coli O157:H7 str. EDL933 iron-hydroxamate transporter substrate-binding subunit NP_285848.1 174898 D 155864 CDS NP_285849.1 15799837 956868 175785..177767 1 NC_002655.2 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome; iron-hydroxamate transporter permease subunit 177767 fhuB 956868 fhuB Escherichia coli O157:H7 str. EDL933 iron-hydroxamate transporter permease subunit NP_285849.1 175785 D 155864 CDS NP_285850.1 15799838 956871 complement(177802..179082) 1 NC_002655.2 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 179082 hemL 956871 hemL Escherichia coli O157:H7 str. EDL933 glutamate-1-semialdehyde aminotransferase NP_285850.1 177802 R 155864 CDS NP_285851.1 15799839 956872 179307..180728 1 NC_002655.2 Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein 180728 yadQ 956872 yadQ Escherichia coli O157:H7 str. EDL933 chloride channel protein NP_285851.1 179307 D 155864 CDS NP_285852.1 15799840 956873 180810..181154 1 NC_002655.2 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 181154 yadR 956873 yadR Escherichia coli O157:H7 str. EDL933 iron-sulfur cluster insertion protein ErpA NP_285852.1 180810 D 155864 CDS NP_285853.1 15799841 956874 complement(181201..181824) 1 NC_002655.2 hypothetical protein 181824 yadS 956874 yadS Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285853.1 181201 R 155864 CDS NP_285854.1 15799842 956876 complement(181862..182662) 1 NC_002655.2 solute binding component of the vitamin B12 transport system BtuCDF; vitamin B12-transporter protein BtuF 182662 yadT 956876 yadT Escherichia coli O157:H7 str. EDL933 vitamin B12-transporter protein BtuF NP_285854.1 181862 R 155864 CDS NP_285855.1 15799843 956877 complement(182655..183353) 1 NC_002655.2 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 183353 pfs 956877 pfs Escherichia coli O157:H7 str. EDL933 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase NP_285855.1 182655 R 155864 CDS NP_285856.1 15799844 956878 183437..184954 1 NC_002655.2 forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase 184954 dgt 956878 dgt Escherichia coli O157:H7 str. EDL933 deoxyguanosinetriphosphate triphosphohydrolase NP_285856.1 183437 D 155864 CDS NP_285857.1 15799845 956879 185084..186508 1 NC_002655.2 protease Do; required at high temperature; degrades damaged proteins; serine endoprotease 186508 htrA 956879 htrA Escherichia coli O157:H7 str. EDL933 serine endoprotease NP_285857.1 185084 D 155864 CDS NP_285858.2 161367651 956880 186663..187820 1 NC_002655.2 regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization; carbohydrate diacid transcriptional activator CdaR 187820 yaeG 956880 yaeG Escherichia coli O157:H7 str. EDL933 carbohydrate diacid transcriptional activator CdaR NP_285858.2 186663 D 155864 CDS NP_285859.1 15799847 956884 complement(187909..188295) 1 NC_002655.2 hypothetical protein 188295 yaeH 956884 yaeH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285859.1 187909 R 155864 CDS NP_285860.1 15799848 956888 complement(188610..189434) 1 NC_002655.2 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 189434 dapD 956888 dapD Escherichia coli O157:H7 str. EDL933 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase NP_285860.1 188610 R 155864 CDS NP_285861.1 15799849 956891 complement(189465..192137) 1 NC_002655.2 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; PII uridylyl-transferase 192137 glnD 956891 glnD Escherichia coli O157:H7 str. EDL933 PII uridylyl-transferase NP_285861.1 189465 R 155864 CDS NP_285862.1 15799850 956892 complement(192199..192993) 1 NC_002655.2 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 192993 map 956892 map Escherichia coli O157:H7 str. EDL933 methionine aminopeptidase NP_285862.1 192199 R 155864 CDS NP_285863.1 15799851 956893 193361..194086 1 NC_002655.2 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 194086 rpsB 956893 rpsB Escherichia coli O157:H7 str. EDL933 30S ribosomal protein S2 NP_285863.1 193361 D 155864 CDS NP_285864.1 15799852 956894 194344..195195 1 NC_002655.2 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 195195 tsf 956894 tsf Escherichia coli O157:H7 str. EDL933 elongation factor Ts NP_285864.1 194344 D 155864 CDS NP_285865.1 15799853 956895 195342..196067 1 NC_002655.2 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 196067 pyrH 956895 pyrH Escherichia coli O157:H7 str. EDL933 uridylate kinase NP_285865.1 195342 D 155864 CDS NP_285866.1 15799854 956896 196217..196774 1 NC_002655.2 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 196774 frr 956896 frr Escherichia coli O157:H7 str. EDL933 ribosome recycling factor NP_285866.1 196217 D 155864 CDS NP_285867.1 15799855 956898 196866..198062 1 NC_002655.2 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 198062 yaeM 956898 yaeM Escherichia coli O157:H7 str. EDL933 1-deoxy-D-xylulose 5-phosphate reductoisomerase NP_285867.1 196866 D 155864 CDS NP_285868.1 15799856 956899 198248..199009 1 NC_002655.2 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 199009 yaeS 956899 yaeS Escherichia coli O157:H7 str. EDL933 undecaprenyl pyrophosphate synthase NP_285868.1 198248 D 155864 CDS NP_285869.2 161367650 956900 199022..199879 1 NC_002655.2 catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate; CDP-diglyceride synthase 199879 cdsA 956900 cdsA Escherichia coli O157:H7 str. EDL933 CDP-diglyceride synthase NP_285869.2 199022 D 155864 CDS NP_285870.1 15799858 956902 199891..201243 1 NC_002655.2 catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response; zinc metallopeptidase RseP 201243 yaeL 956902 yaeL Escherichia coli O157:H7 str. EDL933 zinc metallopeptidase RseP NP_285870.1 199891 D 155864 CDS NP_285871.1 15799859 956907 201273..203705 1 NC_002655.2 part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins; outer membrane protein assembly factor YaeT 203705 yaeT 956907 yaeT Escherichia coli O157:H7 str. EDL933 outer membrane protein assembly factor YaeT NP_285871.1 201273 D 155864 CDS NP_285872.1 15799860 956909 203826..204311 1 NC_002655.2 periplasmic chaperone 204311 hlpA 956909 hlpA Escherichia coli O157:H7 str. EDL933 periplasmic chaperone NP_285872.1 203826 D 155864 CDS NP_285873.1 15799861 956910 204315..205340 1 NC_002655.2 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 205340 lpxD 956910 lpxD Escherichia coli O157:H7 str. EDL933 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase NP_285873.1 204315 D 155864 CDS NP_285874.1 15799862 956911 205445..205900 1 NC_002655.2 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 205900 fabZ 956911 fabZ Escherichia coli O157:H7 str. EDL933 (3R)-hydroxymyristoyl-ACP dehydratase NP_285874.1 205445 D 155864 CDS NP_285875.1 15799863 956912 205904..206692 1 NC_002655.2 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 206692 lpxA 956912 lpxA Escherichia coli O157:H7 str. EDL933 UDP-N-acetylglucosamine acyltransferase NP_285875.1 205904 D 155864 CDS NP_285876.1 15799864 956914 206692..207840 1 NC_002655.2 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 207840 lpxB 956914 lpxB Escherichia coli O157:H7 str. EDL933 lipid-A-disaccharide synthase NP_285876.1 206692 D 155864 CDS NP_285877.1 15799865 956915 207837..208433 1 NC_002655.2 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 208433 rnhB 956915 rnhB Escherichia coli O157:H7 str. EDL933 ribonuclease HII NP_285877.1 207837 D 155864 CDS NP_285878.1 15799866 956917 208470..211952 1 NC_002655.2 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 211952 dnaE 956917 dnaE Escherichia coli O157:H7 str. EDL933 DNA polymerase III subunit alpha NP_285878.1 208470 D 155864 CDS NP_285879.1 15799867 956919 211965..212924 1 NC_002655.2 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 212924 accA 956919 accA Escherichia coli O157:H7 str. EDL933 acetyl-CoA carboxylase carboxyltransferase subunit alpha NP_285879.1 211965 D 155864 CDS NP_285880.1 15799868 956921 213023..215164 1 NC_002655.2 lysine decarboxylase 2, constitutive 215164 ldcC 956921 ldcC Escherichia coli O157:H7 str. EDL933 lysine decarboxylase 2, constitutive NP_285880.1 213023 D 155864 CDS NP_285881.2 161367649 956922 215221..215610 1 NC_002655.2 hypothetical protein 215610 yaeR 956922 yaeR Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285881.2 215221 D 155864 CDS NP_285882.1 15799870 956928 215675..216970 1 NC_002655.2 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase; tRNA(Ile)-lysidine synthetase 216970 tilS 956928 tilS Escherichia coli O157:H7 str. EDL933 tRNA(Ile)-lysidine synthetase NP_285882.1 215675 D 155864 CDS NP_285883.1 15799871 956930 complement(217023..217283) 1 NC_002655.2 Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination; Rho-binding antiterminator 217283 yaeO 956930 yaeO Escherichia coli O157:H7 str. EDL933 Rho-binding antiterminator NP_285883.1 217023 R 155864 CDS NP_285884.1 15799872 956931 217636..218094 1 NC_002655.2 hypothetical protein 218094 956931 Z0202 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285884.1 217636 D 155864 CDS NP_285885.1 15799873 956932 218178..218588 1 NC_002655.2 peptidyl-tRNA hydrolase domain-containing protein 218588 yaeJ 956932 yaeJ Escherichia coli O157:H7 str. EDL933 peptidyl-tRNA hydrolase domain-containing protein NP_285885.1 218178 D 155864 CDS NP_285886.1 15799874 956934 218602..219312 1 NC_002655.2 lipoprotein involved with copper homeostasis and adhesion 219312 cutF 956934 cutF Escherichia coli O157:H7 str. EDL933 lipoprotein involved with copper homeostasis and adhesion NP_285886.1 218602 D 155864 CDS NP_285887.1 15799875 956935 complement(219512..220336) 1 NC_002655.2 hypothetical protein 220336 yaeF 956935 yaeF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285887.1 219512 R 155864 CDS NP_285888.1 15799876 956936 complement(220389..222107) 1 NC_002655.2 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 222107 proS 956936 proS Escherichia coli O157:H7 str. EDL933 prolyl-tRNA synthetase NP_285888.1 220389 R 155864 CDS NP_285889.1 15799877 956938 complement(222218..222925) 1 NC_002655.2 hypothetical protein 222925 956938 Z0207 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285889.1 222218 R 155864 CDS NP_285890.1 15799878 956941 complement(222922..223326) 1 NC_002655.2 outer membrane lipoprotein 223326 rcsF 956941 rcsF Escherichia coli O157:H7 str. EDL933 outer membrane lipoprotein NP_285890.1 222922 R 155864 CDS NP_285891.1 15799879 956942 complement(223444..224259) 1 NC_002655.2 DL-methionine transporter substrate-binding subunit 224259 metQ 956942 metQ Escherichia coli O157:H7 str. EDL933 DL-methionine transporter substrate-binding subunit NP_285891.1 223444 R 155864 CDS NP_285892.1 15799880 956943 complement(224299..224952) 1 NC_002655.2 part of the MetNIQ methionine uptake system; DL-methionine transporter permease 224952 yaeE 956943 yaeE Escherichia coli O157:H7 str. EDL933 DL-methionine transporter permease NP_285892.1 224299 R 155864 CDS NP_285893.1 15799881 956944 complement(224945..225976) 1 NC_002655.2 part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding subunit 225976 metN 956944 metN Escherichia coli O157:H7 str. EDL933 DL-methionine transporter ATP-binding subunit NP_285893.1 224945 R 155864 CDS NP_285894.1 15799882 956945 226164..226739 1 NC_002655.2 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 226739 yaeD 956945 yaeD Escherichia coli O157:H7 str. EDL933 D,D-heptose 1,7-bisphosphate phosphatase NP_285894.1 226164 D 155864 CDS NP_285895.1 15799883 956971 232497..233300 1 NC_002655.2 catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; 2,5-diketo-D-gluconate reductase B 233300 dkgB 956971 dkgB Escherichia coli O157:H7 str. EDL933 2,5-diketo-D-gluconate reductase B NP_285895.1 232497 D 155864 CDS NP_285896.1 15799884 956972 complement(233297..234211) 1 NC_002655.2 LysR family transcriptional regulator 234211 yafC 956972 yafC Escherichia coli O157:H7 str. EDL933 LysR family transcriptional regulator NP_285896.1 233297 R 155864 CDS NP_285897.1 15799885 956973 234452..235252 1 NC_002655.2 hypothetical protein 235252 yafD 956973 yafD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285897.1 234452 D 155864 CDS NP_285898.1 15799886 956974 235330..236100 1 NC_002655.2 hypothetical protein 236100 956974 Z0233 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285898.1 235330 D 155864 CDS NP_285899.1 15799887 956975 complement(236148..237506) 1 NC_002655.2 catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall; membrane-bound lytic murein transglycosylase D 237506 mltD 956975 mltD Escherichia coli O157:H7 str. EDL933 membrane-bound lytic murein transglycosylase D NP_285899.1 236148 R 155864 CDS NP_285900.1 15799888 956977 complement(237578..238333) 1 NC_002655.2 catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione; hydroxyacylglutathione hydrolase 238333 gloB 956977 gloB Escherichia coli O157:H7 str. EDL933 hydroxyacylglutathione hydrolase NP_285900.1 237578 R 155864 CDS NP_285901.1 15799889 956978 238349..239089 1 NC_002655.2 hypothetical protein 239089 yafS 956978 yafS Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285901.1 238349 D 155864 CDS NP_285902.1 15799890 956979 complement(239086..239553) 1 NC_002655.2 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H 239553 rnhA 956979 rnhA Escherichia coli O157:H7 str. EDL933 ribonuclease H NP_285902.1 239086 R 155864 CDS NP_285903.1 15799891 956980 239618..240349 1 NC_002655.2 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 240349 dnaQ 956980 dnaQ Escherichia coli O157:H7 str. EDL933 DNA polymerase III subunit epsilon NP_285903.1 239618 D 155864 CDS NP_285904.1 15799892 956982 240887..241687 1 NC_002655.2 hypothetical protein 241687 956982 Z0243 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285904.1 240887 D 155864 CDS NP_285905.1 15799893 956983 complement(241872..242168) 1 NC_002655.2 No significant matches; hypothetical protein 242168 956983 Z0244 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285905.1 241872 R 155864 CDS NP_285906.1 15799894 956985 complement(242165..242620) 1 NC_002655.2 No significant matches; hypothetical protein 242620 956985 Z0245 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285906.1 242165 R 155864 CDS NP_285907.1 15799895 956986 complement(242617..243213) 1 NC_002655.2 No significant matches; hypothetical protein 243213 956986 Z0246 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285907.1 242617 R 155864 CDS NP_285908.1 15799896 956987 complement(243292..243513) 1 NC_002655.2 No significant matches; hypothetical protein 243513 956987 Z0247 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285908.1 243292 R 155864 CDS NP_285909.1 15799897 956988 complement(243534..244013) 1 NC_002655.2 hypothetical protein 244013 956988 Z0248 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285909.1 243534 R 155864 CDS NP_285910.1 15799898 956989 complement(243979..245478) 1 NC_002655.2 No significant matches; hypothetical protein 245478 956989 Z0249 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285910.1 243979 R 155864 CDS NP_285911.1 15799899 956993 complement(245399..248833) 1 NC_002655.2 macrophage toxin 248833 956993 Z0250 Escherichia coli O157:H7 str. EDL933 macrophage toxin NP_285911.1 245399 R 155864 CDS NP_285912.1 15799900 956995 complement(248970..249764) 1 NC_002655.2 No significant matches; hypothetical protein 249764 956995 Z0251 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285912.1 248970 R 155864 CDS NP_285913.1 15799901 956996 complement(249761..250381) 1 NC_002655.2 No significant matches; hypothetical protein 250381 956996 Z0252 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285913.1 249761 R 155864 CDS NP_285914.1 15799902 956997 complement(250386..251129) 1 NC_002655.2 No significant matches; hypothetical protein 251129 956997 Z0253 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285914.1 250386 R 155864 CDS NP_285915.1 15799903 956999 complement(251126..253897) 1 NC_002655.2 protease 253897 956999 Z0254 Escherichia coli O157:H7 str. EDL933 protease NP_285915.1 251126 R 155864 CDS NP_285916.1 15799904 957001 complement(253906..254667) 1 NC_002655.2 No significant matches; hypothetical protein 254667 957001 Z0255 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285916.1 253906 R 155864 CDS NP_285917.1 15799905 957002 complement(254672..256003) 1 NC_002655.2 hypothetical protein 256003 957002 Z0256 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285917.1 254672 R 155864 CDS NP_285918.1 15799906 957003 complement(256006..256530) 1 NC_002655.2 No significant matches; hypothetical protein 256530 957003 Z0257 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285918.1 256006 R 155864 CDS NP_285919.1 15799907 957005 complement(256527..257828) 1 NC_002655.2 No significant matches; hypothetical protein 257828 957005 Z0258 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285919.1 256527 R 155864 CDS NP_285920.1 15799908 957006 complement(257832..258914) 1 NC_002655.2 No significant matches; hypothetical protein 258914 957006 Z0259 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285920.1 257832 R 155864 CDS NP_285921.1 15799909 957008 complement(258878..260728) 1 NC_002655.2 No significant matches; hypothetical protein 260728 957008 Z0260 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285921.1 258878 R 155864 CDS NP_285922.1 15799910 957009 complement(260732..261145) 1 NC_002655.2 No significant matches; hypothetical protein 261145 957009 Z0261 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285922.1 260732 R 155864 CDS NP_285923.1 15799911 957010 complement(261236..262627) 1 NC_002655.2 hypothetical protein 262627 957010 Z0262 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285923.1 261236 R 155864 CDS NP_285924.1 15799912 957012 complement(262678..262902) 1 NC_002655.2 No significant matches; hypothetical protein 262902 957012 Z0263 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285924.1 262678 R 155864 CDS NP_285925.1 15799913 957014 complement(262937..263437) 1 NC_002655.2 hypothetical protein 263437 957014 Z0264 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285925.1 262937 R 155864 CDS NP_285926.1 15799914 957016 263864..264007 1 NC_002655.2 No significant matches; hypothetical protein 264007 957016 Z0265 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285926.1 263864 D 155864 CDS NP_285927.1 15799915 957018 264134..264652 1 NC_002655.2 hypothetical protein 264652 957018 Z0266 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285927.1 264134 D 155864 CDS NP_285928.1 15799916 957020 264862..267003 1 NC_002655.2 hypothetical protein 267003 957020 Z0267 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285928.1 264862 D 155864 CDS NP_285929.1 15799917 957021 267079..271293 1 NC_002655.2 hypothetical protein 271293 957021 Z0268 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285929.1 267079 D 155864 CDS NP_285930.1 15799918 957022 271296..271907 1 NC_002655.2 hypothetical protein 271907 957022 Z0269 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285930.1 271296 D 155864 CDS NP_285931.1 15799919 957023 272653..273789 1 NC_002655.2 hypothetical protein 273789 957023 Z0271 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285931.1 272653 D 155864 CDS NP_285932.1 15799920 957024 273792..275552 1 NC_002655.2 hypothetical protein 275552 957024 Z0272 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285932.1 273792 D 155864 CDS NP_285933.1 15799921 957025 complement(275640..275777) 1 NC_002655.2 No significant matches; hypothetical protein 275777 957025 Z0273 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285933.1 275640 R 155864 CDS NP_285934.1 15799922 957026 275754..276017 1 NC_002655.2 hypothetical protein 276017 957026 Z0274 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285934.1 275754 D 155864 CDS NP_285935.1 15799923 957027 276198..277370 1 NC_002655.2 hypothetical protein 277370 957027 Z0275 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285935.1 276198 D 155864 CDS NP_285936.1 15799924 957028 complement(277488..278258) 1 NC_002655.2 hypothetical protein 278258 yafV 957028 yafV Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285936.1 277488 R 155864 CDS NP_285937.1 15799925 957030 278412..278885 1 NC_002655.2 inactivates vertebrate C-type lysozyme; C-lysozyme inhibitor 278885 ykfE 957030 ykfE Escherichia coli O157:H7 str. EDL933 C-lysozyme inhibitor NP_285937.1 278412 D 155864 CDS NP_285938.2 161367648 957031 complement(278928..281372) 1 NC_002655.2 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase 281372 fadE 957031 fadE Escherichia coli O157:H7 str. EDL933 acyl-CoA dehydrogenase NP_285938.2 278928 R 155864 CDS NP_285939.1 15799927 957034 281612..282190 1 NC_002655.2 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 282190 gmhA 957034 gmhA Escherichia coli O157:H7 str. EDL933 phosphoheptose isomerase NP_285939.1 281612 D 155864 CDS NP_285940.1 15799928 957036 282295..283062 1 NC_002655.2 amidotransferase 283062 yafJ 957036 yafJ Escherichia coli O157:H7 str. EDL933 amidotransferase NP_285940.1 282295 D 155864 CDS NP_285941.1 15799929 957037 complement(283033..283773) 1 NC_002655.2 hypothetical protein 283773 yafK 957037 yafK Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285941.1 283033 R 155864 CDS NP_285942.1 15799930 957038 complement(283929..284132) 1 NC_002655.2 hypothetical protein 284132 957038 Z0284 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285942.1 283929 R 155864 CDS NP_285943.1 15799931 957039 complement(284208..284468) 1 NC_002655.2 damage-inducible protein J 284468 dinJ 957039 dinJ Escherichia coli O157:H7 str. EDL933 damage-inducible protein J NP_285943.1 284208 R 155864 CDS NP_285944.1 15799932 957040 284678..285427 1 NC_002655.2 lipoprotein 285427 yafL 957040 yafL Escherichia coli O157:H7 str. EDL933 lipoprotein NP_285944.1 284678 D 155864 CDS NP_285945.1 15799933 957043 285603..285899 1 NC_002655.2 hypothetical protein 285899 yafM 957043 yafM Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285945.1 285603 D 155864 CDS NP_285946.1 15799934 957044 complement(286245..287984) 1 NC_002655.2 flagellar biosynthesis 287984 fhiA 957044 fhiA Escherichia coli O157:H7 str. EDL933 flagellar biosynthesis NP_285946.1 286245 R 155864 CDS NP_285947.1 15799935 957045 287929..288714 1 NC_002655.2 hypothetical protein 288714 mbhA 957045 mbhA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285947.1 287929 D 155864 CDS NP_285948.1 15799936 957047 288785..289840 1 NC_002655.2 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 289840 dinP 957047 dinP Escherichia coli O157:H7 str. EDL933 DNA polymerase IV NP_285948.1 288785 D 155864 CDS NP_285949.1 15799937 957048 289892..290185 1 NC_002655.2 antitoxin of the YafO-YafN toxin-antitoxin system 290185 yafN 957048 yafN Escherichia coli O157:H7 str. EDL933 antitoxin of the YafO-YafN toxin-antitoxin system NP_285949.1 289892 D 155864 CDS NP_285950.1 15799938 957049 290188..290586 1 NC_002655.2 YafO overproduction induces toxicity; it is believed to be the toxin of a toxin-antitoxin pair; unknown function; toxin YafO 290586 yafO 957049 yafO Escherichia coli O157:H7 str. EDL933 toxin YafO NP_285950.1 290188 D 155864 CDS NP_285951.1 15799939 957051 290596..291048 1 NC_002655.2 hypothetical protein 291048 yafP 957051 yafP Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285951.1 290596 D 155864 CDS NP_285952.1 15799940 957054 291355..291621 1 NC_002655.2 hypothetical protein 291621 957054 Z0296 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285952.1 291355 D 155864 CDS NP_285953.1 15799941 957057 291590..292090 1 NC_002655.2 similar to release factor 1 and 2; peptide chain release factor-like protein 292090 prfH 957057 prfH Escherichia coli O157:H7 str. EDL933 peptide chain release factor-like protein NP_285953.1 291590 D 155864 CDS NP_285954.1 15799942 957058 complement(292147..293604) 1 NC_002655.2 aminoacyl-histidine dipeptidase 293604 pepD 957058 pepD Escherichia coli O157:H7 str. EDL933 aminoacyl-histidine dipeptidase NP_285954.1 292147 R 155864 CDS NP_285955.1 15799943 957059 293865..294323 1 NC_002655.2 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 294323 gpt 957059 gpt Escherichia coli O157:H7 str. EDL933 xanthine-guanine phosphoribosyltransferase NP_285955.1 293865 D 155864 CDS NP_285956.1 15799944 957063 294415..295659 1 NC_002655.2 forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation; fermentation/respiration switch protein 295659 frsA 957063 frsA Escherichia coli O157:H7 str. EDL933 fermentation/respiration switch protein NP_285956.1 294415 D 155864 CDS NP_285957.1 15799945 957064 295717..296118 1 NC_002655.2 involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS; DNA-binding transcriptional regulator Crl 296118 crl 957064 crl Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator Crl NP_285957.1 295717 D 155864 CDS NP_285958.1 15799946 957066 complement(296157..297212) 1 NC_002655.2 outer membrane phosphoporin protein E 297212 phoE 957066 phoE Escherichia coli O157:H7 str. EDL933 outer membrane phosphoporin protein E NP_285958.1 296157 R 155864 CDS NP_285959.1 15799947 957067 297500..298603 1 NC_002655.2 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 298603 proB 957067 proB Escherichia coli O157:H7 str. EDL933 gamma-glutamyl kinase NP_285959.1 297500 D 155864 CDS NP_285960.1 15799948 957068 298615..299868 1 NC_002655.2 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 299868 proA 957068 proA Escherichia coli O157:H7 str. EDL933 gamma-glutamyl phosphate reductase NP_285960.1 298615 D 155864 CDS NP_285961.1 15799949 957072 complement(300073..301047) 1 NC_002655.2 integrase for prophage CP-933H 301047 intH 957072 intH Escherichia coli O157:H7 str. EDL933 integrase for prophage CP-933H NP_285961.1 300073 R 155864 CDS NP_285962.1 15799950 957073 complement(301423..301812) 1 NC_002655.2 hypothetical protein 301812 957073 Z0308 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285962.1 301423 R 155864 CDS NP_285963.1 15799951 957076 complement(301940..302653) 1 NC_002655.2 cI repressor protein for prophage CP-933H 302653 957076 Z0309 Escherichia coli O157:H7 str. EDL933 cI repressor protein for prophage CP-933H NP_285963.1 301940 R 155864 CDS NP_285964.1 15799952 957081 303073..303366 1 NC_002655.2 cII antiterminator protein for prophage CP-933H 303366 957081 Z0310 Escherichia coli O157:H7 str. EDL933 cII antiterminator protein for prophage CP-933H NP_285964.1 303073 D 155864 CDS NP_285965.1 15799953 957082 303399..304007 1 NC_002655.2 hypothetical protein 304007 957082 Z0311 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285965.1 303399 D 155864 CDS NP_285966.1 15799954 957085 303947..304321 1 NC_002655.2 hypothetical protein 304321 957085 Z0312 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285966.1 303947 D 155864 CDS NP_285967.1 15799955 957087 304318..304629 1 NC_002655.2 No significant matches; hypothetical protein 304629 957087 Z0313 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285967.1 304318 D 155864 CDS NP_285968.1 15799956 957088 304629..305339 1 NC_002655.2 hypothetical protein 305339 957088 Z0314 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285968.1 304629 D 155864 CDS NP_285969.1 15799957 957089 305351..305803 1 NC_002655.2 hypothetical protein 305803 957089 Z0315 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285969.1 305351 D 155864 CDS NP_285970.1 15799958 957090 complement(305775..306368) 1 NC_002655.2 hypothetical protein 306368 957090 Z0316 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285970.1 305775 R 155864 CDS NP_285971.1 15799959 957092 complement(306368..306865) 1 NC_002655.2 tail fiber protein from prophage CP-933H 306865 957092 Z0317 Escherichia coli O157:H7 str. EDL933 tail fiber protein from prophage CP-933H NP_285971.1 306368 R 155864 CDS NP_285972.1 15799960 957093 306856..307446 1 NC_002655.2 DNA invertase from prophage CP-933H 307446 pinH 957093 pinH Escherichia coli O157:H7 str. EDL933 DNA invertase from prophage CP-933H NP_285972.1 306856 D 155864 CDS NP_285973.1 15799961 957094 complement(307504..308277) 1 NC_002655.2 hypothetical protein 308277 957094 Z0319 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285973.1 307504 R 155864 CDS NP_285974.1 15799962 957095 309101..309844 1 NC_002655.2 AraC family transcriptional regulator 309844 957095 Z0321 Escherichia coli O157:H7 str. EDL933 AraC family transcriptional regulator NP_285974.1 309101 D 155864 CDS NP_285975.1 15799963 957096 complement(309886..310251) 1 NC_002655.2 hypothetical protein 310251 957096 Z0322 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285975.1 309886 R 155864 CDS NP_285976.1 15799964 957097 310756..311988 1 NC_002655.2 integrase for prophage CP-933I 311988 957097 Z0324 Escherichia coli O157:H7 str. EDL933 integrase for prophage CP-933I NP_285976.1 310756 D 155864 CDS NP_285977.1 15799965 957099 311992..312408 1 NC_002655.2 No significant matches; hypothetical protein 312408 957099 Z0325 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285977.1 311992 D 155864 CDS NP_285978.1 15799966 957100 312381..312998 1 NC_002655.2 No significant matches; hypothetical protein 312998 957100 Z0326 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285978.1 312381 D 155864 CDS NP_285979.1 15799967 957102 312998..313456 1 NC_002655.2 No significant matches; hypothetical protein 313456 957102 Z0327 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285979.1 312998 D 155864 CDS NP_285980.1 15799968 957104 313449..314081 1 NC_002655.2 No significant matches; hypothetical protein 314081 957104 Z0328 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285980.1 313449 D 155864 CDS NP_285981.1 15799969 957106 314112..314702 1 NC_002655.2 No significant matches; hypothetical protein 314702 957106 Z0330 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285981.1 314112 D 155864 CDS NP_285982.1 15799970 957107 314702..315268 1 NC_002655.2 No significant matches; hypothetical protein 315268 957107 Z0331 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285982.1 314702 D 155864 CDS NP_285983.1 15799971 957109 complement(315678..315950) 1 NC_002655.2 activator encoded in prophage CP-933I 315950 957109 Z0332 Escherichia coli O157:H7 str. EDL933 activator encoded in prophage CP-933I NP_285983.1 315678 R 155864 CDS NP_285984.1 15799972 957110 complement(315956..316507) 1 NC_002655.2 polarity suppression protein encoded in CP-933I 316507 psuI 957110 psuI Escherichia coli O157:H7 str. EDL933 polarity suppression protein encoded in CP-933I NP_285984.1 315956 R 155864 CDS NP_285985.1 15799973 957111 complement(316504..317256) 1 NC_002655.2 capsid morphogenesis protein encoded in CP-933I 317256 sidI 957111 sidI Escherichia coli O157:H7 str. EDL933 capsid morphogenesis protein encoded in CP-933I NP_285985.1 316504 R 155864 CDS NP_285986.1 15799974 957112 317659..317829 1 NC_002655.2 No significant matches; hypothetical protein 317829 957112 Z0335 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285986.1 317659 D 155864 CDS NP_285987.1 15799975 957114 318190..318450 1 NC_002655.2 regulatory protein encoded in prophage CP-933I 318450 957114 Z0336 Escherichia coli O157:H7 str. EDL933 regulatory protein encoded in prophage CP-933I NP_285987.1 318190 D 155864 CDS NP_285988.1 15799976 957116 318447..319004 1 NC_002655.2 regulator encoded in prophage CP-933I 319004 957116 Z0337 Escherichia coli O157:H7 str. EDL933 regulator encoded in prophage CP-933I NP_285988.1 318447 D 155864 CDS NP_285989.1 15799977 957117 319222..319545 1 NC_002655.2 hypothetical protein 319545 957117 Z0338 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285989.1 319222 D 155864 CDS NP_285990.1 15799978 957118 319502..321892 1 NC_002655.2 alpha replication protein of prophage CP-933I 321892 957118 Z0339 Escherichia coli O157:H7 str. EDL933 alpha replication protein of prophage CP-933I NP_285990.1 319502 D 155864 CDS NP_285991.1 15799979 957120 complement(322025..322981) 1 NC_002655.2 hypothetical protein 322981 957120 Z0340 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285991.1 322025 R 155864 CDS NP_285993.1 15799981 957123 complement(323657..324556) 1 NC_002655.2 LysR family transcriptional regulator 324556 957123 Z0342 Escherichia coli O157:H7 str. EDL933 LysR family transcriptional regulator NP_285993.1 323657 R 155864 CDS NP_285994.1 15799982 957124 324655..325377 1 NC_002655.2 oxidoreductase 325377 957124 Z0343 Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_285994.1 324655 D 155864 CDS NP_285995.1 15799983 957130 325544..325822 1 NC_002655.2 No significant matches; hypothetical protein 325822 957130 Z0344 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285995.1 325544 D 155864 CDS NP_285996.1 15799984 957131 326097..326246 1 NC_002655.2 No significant matches; hypothetical protein 326246 957131 Z0345 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285996.1 326097 D 155864 CDS NP_285997.1 15799985 957132 complement(326525..327409) 1 NC_002655.2 LysR family transcriptional regulator 327409 957132 Z0346 Escherichia coli O157:H7 str. EDL933 LysR family transcriptional regulator NP_285997.1 326525 R 155864 CDS NP_285998.1 15799986 957133 327673..328731 1 NC_002655.2 hypothetical protein 328731 957133 Z0347 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_285998.1 327673 D 155864 CDS NP_285999.1 15799987 957135 328807..330000 1 NC_002655.2 transcriptional regulator 330000 957135 Z0348 Escherichia coli O157:H7 str. EDL933 transcriptional regulator NP_285999.1 328807 D 155864 CDS NP_286000.1 15799988 957137 complement(330179..331135) 1 NC_002655.2 hypothetical protein 331135 yagQ 957137 yagQ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286000.1 330179 R 155864 CDS NP_286001.1 15799989 957138 complement(331145..333343) 1 NC_002655.2 hypothetical protein 333343 yagR 957138 yagR Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286001.1 331145 R 155864 CDS NP_286002.1 15799990 957139 complement(333340..334296) 1 NC_002655.2 hypothetical protein 334296 yagS 957139 yagS Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286002.1 333340 R 155864 CDS NP_286003.1 15799991 957140 complement(334293..334982) 1 NC_002655.2 xanthine dehydrogenase iron-sulfur-binding subunit 334982 yagT 957140 yagT Escherichia coli O157:H7 str. EDL933 xanthine dehydrogenase iron-sulfur-binding subunit NP_286003.1 334293 R 155864 CDS NP_286004.1 15799992 957141 335400..336014 1 NC_002655.2 hypothetical protein 336014 yagU 957141 yagU Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286004.1 335400 D 155864 CDS NP_286005.1 15799993 957145 complement(336262..336591) 1 NC_002655.2 ferredoxin 336591 ykgJ 957145 ykgJ Escherichia coli O157:H7 str. EDL933 ferredoxin NP_286005.1 336262 R 155864 CDS NP_286006.1 15799994 957146 complement(336904..337659) 1 NC_002655.2 hypothetical protein 337659 yagV 957146 yagV Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286006.1 336904 R 155864 CDS NP_286007.1 15799995 957147 complement(337583..339226) 1 NC_002655.2 receptor 339226 yagW 957147 yagW Escherichia coli O157:H7 str. EDL933 receptor NP_286007.1 337583 R 155864 CDS NP_286008.1 15799996 957149 complement(339216..341741) 1 NC_002655.2 hypothetical protein 341741 yagX 957149 yagX Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286008.1 339216 R 155864 CDS NP_286009.1 15799997 957150 complement(341767..342435) 1 NC_002655.2 hypothetical protein 342435 yagY 957150 yagY Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286009.1 341767 R 155864 CDS NP_286010.1 15799998 957151 complement(342493..343080) 1 NC_002655.2 hypothetical protein 343080 yagZ 957151 yagZ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286010.1 342493 R 155864 CDS NP_286011.1 15799999 957152 complement(343155..343745) 1 NC_002655.2 regulator 343745 ykgK 957152 ykgK Escherichia coli O157:H7 str. EDL933 regulator NP_286011.1 343155 R 155864 CDS NP_286012.1 15800000 957155 complement(344151..344375) 1 NC_002655.2 No significant matches; hypothetical protein 344375 957155 Z0362 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286012.1 344151 R 155864 CDS NP_286013.1 15800001 957160 344522..344713 1 NC_002655.2 hypothetical protein 344713 ykgL 957160 ykgL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286013.1 344522 D 155864 CDS NP_286014.1 15800002 957162 complement(344923..345186) 1 NC_002655.2 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 345186 rpmE2 957162 rpmE2 Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L31 NP_286014.1 344923 R 155864 CDS NP_286015.1 15800003 957163 345429..345830 1 NC_002655.2 hypothetical protein 345830 957163 Z0365 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286015.1 345429 D 155864 CDS NP_286016.1 15800004 957164 345827..346174 1 NC_002655.2 hypothetical protein 346174 957164 Z0366 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286016.1 345827 D 155864 CDS NP_286017.1 15800005 957165 346224..347762 1 NC_002655.2 hypothetical protein 347762 957165 Z0367 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286017.1 346224 D 155864 CDS NP_286018.1 15800006 957166 complement(348575..349717) 1 NC_002655.2 oxidoreductase 349717 957166 Z0369 Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_286018.1 348575 R 155864 CDS NP_286019.1 15800007 957168 complement(349953..350873) 1 NC_002655.2 hypothetical protein 350873 957168 Z0370 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286019.1 349953 R 155864 CDS NP_286020.1 15800008 957169 350967..351956 1 NC_002655.2 LysR family transcriptional regulator 351956 957169 Z0371 Escherichia coli O157:H7 str. EDL933 LysR family transcriptional regulator NP_286020.1 350967 D 155864 CDS NP_286021.1 15800009 957171 complement(352244..352600) 1 NC_002655.2 No significant matches; hypothetical protein 352600 957171 Z0372 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286021.1 352244 R 155864 CDS NP_286022.1 15800010 957173 352631..352759 1 NC_002655.2 No significant matches; hypothetical protein 352759 957173 Z0373 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286022.1 352631 D 155864 CDS NP_286023.1 15800011 957174 complement(352793..353368) 1 NC_002655.2 hypothetical protein 353368 957174 Z0374 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286023.1 352793 R 155864 CDS NP_286024.1 15800012 957175 353934..358187 1 NC_002655.2 adhesin 358187 eaeH 957175 eaeH Escherichia coli O157:H7 str. EDL933 adhesin NP_286024.1 353934 D 155864 CDS NP_286025.1 15800013 957184 complement(358308..359198) 1 NC_002655.2 AraC family transcriptional regulator 359198 ykgA 957184 ykgA Escherichia coli O157:H7 str. EDL933 AraC family transcriptional regulator NP_286025.1 358308 R 155864 CDS NP_286026.1 15800014 957185 359399..360283 1 NC_002655.2 dehydrogenase 360283 957185 Z0377 Escherichia coli O157:H7 str. EDL933 dehydrogenase NP_286026.1 359399 D 155864 CDS NP_286027.1 15800015 957187 complement(360443..361036) 1 NC_002655.2 hypothetical protein 361036 ykgB 957187 ykgB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286027.1 360443 R 155864 CDS NP_286029.1 15800017 957190 complement(361048..361299) 1 NC_002655.2 hypothetical protein 361299 ykgI 957190 ykgI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286029.1 361048 R 155864 CDS NP_286030.2 161367647 957192 complement(361393..362718) 1 NC_002655.2 Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase 362718 ykgC 957192 ykgC Escherichia coli O157:H7 str. EDL933 pyridine nucleotide-disulfide oxidoreductase NP_286030.2 361393 R 155864 CDS NP_286031.1 15800019 957193 362944..363798 1 NC_002655.2 AraC family transcriptional regulator 363798 ykgD 957193 ykgD Escherichia coli O157:H7 str. EDL933 AraC family transcriptional regulator NP_286031.1 362944 D 155864 CDS NP_286032.1 15800020 957194 364325..365044 1 NC_002655.2 dehydrogenase subunit 365044 ykgE 957194 ykgE Escherichia coli O157:H7 str. EDL933 dehydrogenase subunit NP_286032.1 364325 D 155864 CDS NP_286033.1 15800021 957196 365055..366482 1 NC_002655.2 hypothetical protein 366482 ykgF 957196 ykgF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286033.1 365055 D 155864 CDS NP_286034.2 161367646 957198 366475..367170 1 NC_002655.2 hypothetical protein 367170 ykgG 957198 ykgG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286034.2 366475 D 155864 CDS NP_286035.1 15800023 957199 complement(367125..367337) 1 NC_002655.2 hypothetical protein 367337 957199 Z0387 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286035.1 367125 R 155864 CDS NP_286036.1 15800024 957201 complement(367665..368081) 1 NC_002655.2 hypothetical protein 368081 957201 Z0388 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286036.1 367665 R 155864 CDS NP_286037.1 15800025 957202 complement(368263..368505) 1 NC_002655.2 hypothetical protein 368505 957202 Z0389 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286037.1 368263 R 155864 CDS NP_286038.1 15800026 957204 complement(368429..369538) 1 NC_002655.2 hypothetical protein 369538 957204 Z0390 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286038.1 368429 R 155864 CDS NP_286039.1 15800027 957205 complement(369565..370326) 1 NC_002655.2 No significant matches; hypothetical protein 370326 957205 Z0391 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286039.1 369565 R 155864 CDS NP_286040.1 15800028 957206 complement(370480..370956) 1 NC_002655.2 No significant matches; hypothetical protein 370956 957206 Z0392 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286040.1 370480 R 155864 CDS NP_286041.1 15800029 957207 complement(371156..371311) 1 NC_002655.2 No significant matches; hypothetical protein 371311 957207 Z0393 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286041.1 371156 R 155864 CDS NP_286042.1 15800030 957208 complement(371604..371762) 1 NC_002655.2 hypothetical protein 371762 957208 Z0394 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286042.1 371604 R 155864 CDS NP_286043.1 15800031 957209 complement(371783..372166) 1 NC_002655.2 hypothetical protein 372166 957209 Z0395 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286043.1 371783 R 155864 CDS NP_286044.1 15800032 957210 372972..373223 1 NC_002655.2 No significant matches; hypothetical protein 373223 957210 Z0397 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286044.1 372972 D 155864 CDS NP_286045.1 15800033 957211 complement(373225..374913) 1 NC_002655.2 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine; choline dehydrogenase 374913 betA 957211 betA Escherichia coli O157:H7 str. EDL933 choline dehydrogenase NP_286045.1 373225 R 155864 CDS NP_286046.1 15800034 957212 complement(374927..376399) 1 NC_002655.2 catalyzes the formation of betaine from betaine aldehyde; betaine aldehyde dehydrogenase 376399 betB 957212 betB Escherichia coli O157:H7 str. EDL933 betaine aldehyde dehydrogenase NP_286046.1 374927 R 155864 CDS NP_286047.1 15800035 957214 complement(376413..377000) 1 NC_002655.2 HTH-type; bet1; Repressor involved in choline regulation of the bet genes; transcriptional regulator BetI 377000 betI 957214 betI Escherichia coli O157:H7 str. EDL933 transcriptional regulator BetI NP_286047.1 376413 R 155864 CDS NP_286048.1 15800036 957215 377129..379162 1 NC_002655.2 proton-motive-force-driven choline transporter; choline transport protein BetT 379162 betT 957215 betT Escherichia coli O157:H7 str. EDL933 choline transport protein BetT NP_286048.1 377129 D 155864 CDS NP_286049.1 15800037 957216 379670..383719 1 NC_002655.2 beta-barrel outer membrane protein 383719 957216 Z0402 Escherichia coli O157:H7 str. EDL933 beta-barrel outer membrane protein NP_286049.1 379670 D 155864 CDS NP_286050.1 15800038 957219 383852..384949 1 NC_002655.2 hypothetical protein 384949 yahA 957219 yahA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286050.1 383852 D 155864 CDS NP_286051.1 15800039 957221 complement(384991..385251) 1 NC_002655.2 hypothetical protein 385251 957221 Z0404 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286051.1 384991 R 155864 CDS NP_286052.1 15800040 957224 complement(385212..385922) 1 NC_002655.2 hypothetical protein 385922 957224 Z0405 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286052.1 385212 R 155864 CDS NP_286053.1 15800041 957225 complement(386014..386316) 1 NC_002655.2 hypothetical protein 386316 957225 Z0406 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286053.1 386014 R 155864 CDS NP_286054.1 15800042 957226 386779..387384 1 NC_002655.2 transcription factor 387384 yahD 957226 yahD Escherichia coli O157:H7 str. EDL933 transcription factor NP_286054.1 386779 D 155864 CDS NP_286055.1 15800043 957227 387424..388287 1 NC_002655.2 hypothetical protein 388287 yahE 957227 yahE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286055.1 387424 D 155864 CDS NP_286056.1 15800044 957228 388277..389824 1 NC_002655.2 oxidoreductase subunit 389824 yahF 957228 yahF Escherichia coli O157:H7 str. EDL933 oxidoreductase subunit NP_286056.1 388277 D 155864 CDS NP_286057.1 15800045 957234 389824..391242 1 NC_002655.2 hypothetical protein 391242 yahG 957234 yahG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286057.1 389824 D 155864 CDS NP_286058.1 15800046 957235 391757..392707 1 NC_002655.2 forms a homodimer; may be used to synthesize carbomyl phosphate from ATP and carbamate; carbamate kinase 392707 yahI 957235 yahI Escherichia coli O157:H7 str. EDL933 carbamate kinase NP_286058.1 391757 D 155864 CDS NP_286059.1 15800047 957236 392717..394099 1 NC_002655.2 metallo-dependent hydrolase superfamily; deaminase with metallo-dependent hydrolase domain; deaminase 394099 yahJ 957236 yahJ Escherichia coli O157:H7 str. EDL933 deaminase NP_286059.1 392717 D 155864 CDS NP_286060.1 15800048 957239 394398..394808 1 NC_002655.2 hypothetical protein 394808 957239 Z0414 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286060.1 394398 D 155864 CDS NP_286061.1 15800049 957242 395059..396045 1 NC_002655.2 periplasmic binding protein, substrate ribose 396045 957242 Z0415 Escherichia coli O157:H7 str. EDL933 periplasmic binding protein, substrate ribose NP_286061.1 395059 D 155864 CDS NP_286062.1 15800050 957243 396094..396354 1 NC_002655.2 ABC transporter ATP-binding protein 396354 957243 Z0416 Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_286062.1 396094 D 155864 CDS NP_286063.1 15800051 957244 396400..397578 1 NC_002655.2 ABC transporter ATP-binding protein 397578 957244 Z0417 Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_286063.1 396400 D 155864 CDS NP_286064.1 15800052 957245 397571..398542 1 NC_002655.2 permease 398542 957245 Z0418 Escherichia coli O157:H7 str. EDL933 permease NP_286064.1 397571 D 155864 CDS NP_286065.1 15800053 957246 398539..399495 1 NC_002655.2 permease 399495 957246 Z0419 Escherichia coli O157:H7 str. EDL933 permease NP_286065.1 398539 D 155864 CDS NP_286066.1 15800054 957248 399582..400631 1 NC_002655.2 oxidoreductase 400631 yahK 957248 yahK Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_286066.1 399582 D 155864 CDS NP_286067.1 15800055 957249 400874..401689 1 NC_002655.2 hypothetical protein 401689 yahL 957249 yahL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286067.1 400874 D 155864 CDS NP_286068.1 15800056 957252 402210..402350 1 NC_002655.2 hypothetical protein 402350 957252 Z0423 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286068.1 402210 D 155864 CDS NP_286069.1 15800057 957253 complement(402367..403038) 1 NC_002655.2 cytochrome subunit of dehydrogenase 403038 yahN 957253 yahN Escherichia coli O157:H7 str. EDL933 cytochrome subunit of dehydrogenase NP_286069.1 402367 R 155864 CDS NP_286070.1 15800058 957254 403185..403460 1 NC_002655.2 hypothetical protein 403460 yahO 957254 yahO Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286070.1 403185 D 155864 CDS NP_286071.1 15800059 957255 complement(403558..405144) 1 NC_002655.2 regulator for prp operon 405144 prpR 957255 prpR Escherichia coli O157:H7 str. EDL933 regulator for prp operon NP_286071.1 403558 R 155864 CDS NP_286072.1 15800060 957256 405383..406273 1 NC_002655.2 catalyzes the formation of pyruvate and succinate from 2-methylisocitrate; 2-methylisocitrate lyase 406273 prpB 957256 prpB Escherichia coli O157:H7 str. EDL933 2-methylisocitrate lyase NP_286072.1 405383 D 155864 CDS NP_286073.1 15800061 957257 406429..407598 1 NC_002655.2 catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; methylcitrate synthase 407598 prpC 957257 prpC Escherichia coli O157:H7 str. EDL933 methylcitrate synthase NP_286073.1 406429 D 155864 CDS NP_286074.1 15800062 957258 407632..409083 1 NC_002655.2 functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C; 2-methylcitrate dehydratase 409083 prpD 957258 prpD Escherichia coli O157:H7 str. EDL933 2-methylcitrate dehydratase NP_286074.1 407632 D 155864 CDS NP_286075.1 15800063 957259 409123..411009 1 NC_002655.2 catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent; propionyl-CoA synthetase 411009 prpE 957259 prpE Escherichia coli O157:H7 str. EDL933 propionyl-CoA synthetase NP_286075.1 409123 D 155864 CDS NP_286076.1 15800064 957260 complement(411372..411509) 1 NC_002655.2 No significant matches; hypothetical protein 411509 957260 Z0431 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286076.1 411372 R 155864 CDS NP_286077.1 15800065 957261 411903..413162 1 NC_002655.2 cytosine permease 413162 codB 957261 codB Escherichia coli O157:H7 str. EDL933 cytosine permease NP_286077.1 411903 D 155864 CDS NP_286078.1 15800066 957262 413152..414435 1 NC_002655.2 Catalyzes the deamination of cytosine to uracil and ammonia; cytosine deaminase 414435 codA 957262 codA Escherichia coli O157:H7 str. EDL933 cytosine deaminase NP_286078.1 413152 D 155864 CDS NP_286079.1 15800067 957263 complement(414568..415467) 1 NC_002655.2 controls the expression of the cynTSX operon involved in degrading and using cyanate as a sole nitrogen source; DNA-binding transcriptional regulator CynR 415467 cynR 957263 cynR Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator CynR NP_286079.1 414568 R 155864 CDS NP_286080.1 15800068 957265 415577..416236 1 NC_002655.2 carbonic anhydrase 416236 cynT 957265 cynT Escherichia coli O157:H7 str. EDL933 carbonic anhydrase NP_286080.1 415577 D 155864 CDS NP_286081.1 15800069 957266 416267..416737 1 NC_002655.2 catalyzes the reaction of cyanate and bicarbonate to produce ammonia and carbon dioxide; cyanate hydratase 416737 cynS 957266 cynS Escherichia coli O157:H7 str. EDL933 cyanate hydratase NP_286081.1 416267 D 155864 CDS NP_286082.1 15800070 957267 416770..417924 1 NC_002655.2 MFS transporter family member induced in the presence of cyanate as part of a 3 gene operon; not essential; cyanate transporter 417924 cynX 957267 cynX Escherichia coli O157:H7 str. EDL933 cyanate transporter NP_286082.1 416770 D 155864 CDS NP_286083.1 15800071 957269 complement(418027..418638) 1 NC_002655.2 transfers acetyl group from acetyl-CoA to the 6-hydroxyl of galactopyranosides; exact physiological role is unknown; galactoside O-acetyltransferase 418638 lacA 957269 lacA Escherichia coli O157:H7 str. EDL933 galactoside O-acetyltransferase NP_286083.1 418027 R 155864 CDS NP_286084.1 15800072 957270 complement(418704..419957) 1 NC_002655.2 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease 419957 lacY 957270 lacY Escherichia coli O157:H7 str. EDL933 galactoside permease NP_286084.1 418704 R 155864 CDS NP_286085.1 15800073 957271 complement(420009..423083) 1 NC_002655.2 forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon; beta-D-galactosidase 423083 lacZ 957271 lacZ Escherichia coli O157:H7 str. EDL933 beta-D-galactosidase NP_286085.1 420009 R 155864 CDS NP_286086.1 15800074 957273 complement(423206..424288) 1 NC_002655.2 transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer; lac repressor 424288 lacI 957273 lacI Escherichia coli O157:H7 str. EDL933 lac repressor NP_286086.1 423206 R 155864 CDS NP_286087.1 15800075 957278 complement(424325..425278) 1 NC_002655.2 AraC family transcriptional regulator 425278 957278 Z0442 Escherichia coli O157:H7 str. EDL933 AraC family transcriptional regulator NP_286087.1 424325 R 155864 CDS NP_286088.1 15800076 957280 complement(425298..426074) 1 NC_002655.2 hypothetical protein 426074 957280 Z0443 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286088.1 425298 R 155864 CDS NP_286089.1 15800077 957281 complement(426189..427061) 1 NC_002655.2 activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional activator MhpR 427061 mhpR 957281 mhpR Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional activator MhpR NP_286089.1 426189 R 155864 CDS NP_286090.1 15800078 957286 427213..428877 1 NC_002655.2 catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate; 3-(3-hydroxyphenyl)propionate hydroxylase 428877 mhpA 957286 mhpA Escherichia coli O157:H7 str. EDL933 3-(3-hydroxyphenyl)propionate hydroxylase NP_286090.1 427213 D 155864 CDS NP_286091.1 15800079 957287 428879..429823 1 NC_002655.2 catalyzes the cleavage of 3-(2,3-dihydroxyphenyl) propionate into 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate; part of the 3-phenylpropionic acid degradation pathway; member of the protocatechuate 4,5-dioxygenase; 3-(2,3-dihydroxyphenyl)propionate dioxygenase 429823 mhpB 957287 mhpB Escherichia coli O157:H7 str. EDL933 3-(2,3-dihydroxyphenyl)propionate dioxygenase NP_286091.1 428879 D 155864 CDS NP_286092.1 15800080 957288 429778..430707 1 NC_002655.2 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase 430707 mhpC 957288 mhpC Escherichia coli O157:H7 str. EDL933 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase NP_286092.1 429778 D 155864 CDS NP_286093.1 15800081 957289 430717..431526 1 NC_002655.2 catalyzes the formation of 2-keto-4-hydroxypentanoic acid from 2-hydroxypentadienoic acid; 2-keto-4-pentenoate hydratase 431526 mhpD 957289 mhpD Escherichia coli O157:H7 str. EDL933 2-keto-4-pentenoate hydratase NP_286093.1 430717 D 155864 CDS NP_286094.1 15800082 957291 431523..432473 1 NC_002655.2 catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase 432473 mhpF 957291 mhpF Escherichia coli O157:H7 str. EDL933 acetaldehyde dehydrogenase NP_286094.1 431523 D 155864 CDS NP_286095.1 15800083 957292 432470..433483 1 NC_002655.2 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase 433483 mhpE 957292 mhpE Escherichia coli O157:H7 str. EDL933 4-hydroxy-2-ketovalerate aldolase NP_286095.1 432470 D 155864 CDS NP_286096.2 161367645 957293 433659..434870 1 NC_002655.2 3-hydroxyphenylpropionic transporter MhpT 434870 mhpT 957293 mhpT Escherichia coli O157:H7 str. EDL933 3-hydroxyphenylpropionic transporter MhpT NP_286096.2 433659 D 155864 CDS NP_286097.2 161367644 957294 434972..435511 1 NC_002655.2 nucleoprotein/polynucleotide-associated enzyme 435511 yaiL 957294 yaiL Escherichia coli O157:H7 str. EDL933 nucleoprotein/polynucleotide-associated enzyme NP_286097.2 434972 D 155864 CDS NP_286098.1 15800086 957295 complement(435636..436469) 1 NC_002655.2 esterase 436469 yaiM 957295 yaiM Escherichia coli O157:H7 str. EDL933 esterase NP_286098.1 435636 R 155864 CDS NP_286099.1 15800087 957296 complement(436562..437671) 1 NC_002655.2 glutathione-dependent formaldehyde dehydrogenase 437671 adhC 957296 adhC Escherichia coli O157:H7 str. EDL933 glutathione-dependent formaldehyde dehydrogenase NP_286099.1 436562 R 155864 CDS NP_286100.1 15800088 957297 complement(437706..438002) 1 NC_002655.2 formaldehyde-induced negative regulator of the frmRAB operon; regulator protein FrmR 438002 yaiN 957297 yaiN Escherichia coli O157:H7 str. EDL933 regulator protein FrmR NP_286100.1 437706 R 155864 CDS NP_286101.2 161367643 957301 complement(438141..439187) 1 NC_002655.2 Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import; ferric transporter ATP-binding subunit 439187 fbpC 957301 fbpC Escherichia coli O157:H7 str. EDL933 ferric transporter ATP-binding subunit NP_286101.2 438141 R 155864 CDS NP_286102.1 15800090 957302 complement(439199..441277) 1 NC_002655.2 permease component of transport system for ferric iron 441277 afuB 957302 afuB Escherichia coli O157:H7 str. EDL933 permease component of transport system for ferric iron NP_286102.1 439199 R 155864 CDS NP_286103.1 15800091 957305 complement(441346..442377) 1 NC_002655.2 periplasmic ferric iron-binding protein 442377 afuA 957305 afuA Escherichia coli O157:H7 str. EDL933 periplasmic ferric iron-binding protein NP_286103.1 441346 R 155864 CDS NP_286104.1 15800092 957306 complement(442374..443678) 1 NC_002655.2 permease; hexosephosphate transport 443678 957306 Z0461 Escherichia coli O157:H7 str. EDL933 permease; hexosephosphate transport NP_286104.1 442374 R 155864 CDS NP_286105.1 15800093 957307 complement(443763..445304) 1 NC_002655.2 sensor kinase 445304 957307 Z0462 Escherichia coli O157:H7 str. EDL933 sensor kinase NP_286105.1 443763 R 155864 CDS NP_286106.1 15800094 957308 complement(445304..445933) 1 NC_002655.2 response regulator; hexosephosphate transport 445933 957308 Z0463 Escherichia coli O157:H7 str. EDL933 response regulator; hexosephosphate transport NP_286106.1 445304 R 155864 CDS NP_286107.1 15800095 957309 446236..447198 1 NC_002655.2 with TauB and TauC is responsible for taurine uptake.; taurine transporter substrate binding subunit 447198 tauA 957309 tauA Escherichia coli O157:H7 str. EDL933 taurine transporter substrate binding subunit NP_286107.1 446236 D 155864 CDS NP_286108.1 15800096 957311 447211..447978 1 NC_002655.2 Part of the ABC transporter complex tauABC involved in taurine import; taurine transporter ATP-binding subunit 447978 tauB 957311 tauB Escherichia coli O157:H7 str. EDL933 taurine transporter ATP-binding subunit NP_286108.1 447211 D 155864 CDS NP_286109.1 15800097 957312 447975..448802 1 NC_002655.2 taurine transporter subunit 448802 tauC 957312 tauC Escherichia coli O157:H7 str. EDL933 taurine transporter subunit NP_286109.1 447975 D 155864 CDS NP_286110.1 15800098 957313 448799..449650 1 NC_002655.2 catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers; taurine dioxygenase 449650 tauD 957313 tauD Escherichia coli O157:H7 str. EDL933 taurine dioxygenase NP_286110.1 448799 D 155864 CDS NP_286111.1 15800099 957314 complement(449757..450764) 1 NC_002655.2 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 450764 hemB 957314 hemB Escherichia coli O157:H7 str. EDL933 delta-aminolevulinic acid dehydratase NP_286111.1 449757 R 155864 CDS NP_286112.1 15800100 957315 451257..454199 1 NC_002655.2 hypothetical protein 454199 957315 Z0469 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286112.1 451257 D 155864 CDS NP_286113.1 15800101 957317 454242..454910 1 NC_002655.2 DNA-binding transcriptional regulator 454910 yaiV 957317 yaiV Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator NP_286113.1 454242 D 155864 CDS NP_286114.1 15800102 957318 complement(454911..456068) 1 NC_002655.2 this protein has no known enzymatic function; beta-lactam binding protein AmpH 456068 yaiH 957318 yaiH Escherichia coli O157:H7 str. EDL933 beta-lactam binding protein AmpH NP_286114.1 454911 R 155864 CDS NP_286115.1 15800103 957320 456420..457640 1 NC_002655.2 in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope; transporter 457640 sbmA 957320 sbmA Escherichia coli O157:H7 str. EDL933 transporter NP_286115.1 456420 D 155864 CDS NP_286116.1 15800104 957321 457653..458747 1 NC_002655.2 hypothetical protein 458747 yaiW 957321 yaiW Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286116.1 457653 D 155864 CDS NP_286117.1 15800105 957322 complement(458806..459114) 1 NC_002655.2 hypothetical protein 459114 957322 Z0475 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286117.1 458806 R 155864 CDS NP_286118.1 15800106 957324 459242..459586 1 NC_002655.2 hypothetical protein 459586 957324 Z0476 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286118.1 459242 D 155864 CDS NP_286119.1 15800107 957325 complement(459610..460704) 1 NC_002655.2 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 460704 ddl 957325 ddl Escherichia coli O157:H7 str. EDL933 D-alanyl-alanine synthetase A NP_286119.1 459610 R 155864 CDS NP_286120.1 15800108 957326 461167..461427 1 NC_002655.2 hypothetical protein 461427 yaiB 957326 yaiB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286120.1 461167 D 155864 CDS NP_286121.1 15800109 957327 461459..462943 1 NC_002655.2 alkaline phosphatase 462943 phoA 957327 phoA Escherichia coli O157:H7 str. EDL933 alkaline phosphatase NP_286121.1 461459 D 155864 CDS NP_286122.1 15800110 957328 463044..463382 1 NC_002655.2 hypothetical protein 463382 psiF 957328 psiF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286122.1 463044 D 155864 CDS NP_286123.1 15800111 957331 463484..464599 1 NC_002655.2 catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis; diguanylate cyclase AdrA 464599 adrA 957331 adrA Escherichia coli O157:H7 str. EDL933 diguanylate cyclase AdrA NP_286123.1 463484 D 155864 CDS NP_286124.1 15800112 957332 complement(464616..465425) 1 NC_002655.2 catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 465425 proC 957332 proC Escherichia coli O157:H7 str. EDL933 pyrroline-5-carboxylate reductase NP_286124.1 464616 R 155864 CDS NP_286125.2 161367642 957333 465545..466003 1 NC_002655.2 hypothetical protein 466003 957333 Z0483 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286125.2 465545 D 155864 CDS NP_286126.1 15800114 957334 466186..466710 1 NC_002655.2 type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 466710 aroL 957334 aroL Escherichia coli O157:H7 str. EDL933 shikimate kinase NP_286126.1 466186 D 155864 CDS NP_286127.1 15800115 957335 466760..466951 1 NC_002655.2 hypothetical protein 466951 yaiA 957335 yaiA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286127.1 466760 D 155864 CDS NP_286128.1 15800116 957336 467209..467886 1 NC_002655.2 hypothetical protein 467886 aroM 957336 aroM Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286128.1 467209 D 155864 CDS NP_286129.1 15800117 957337 467958..468242 1 NC_002655.2 hypothetical protein 468242 yaiE 957337 yaiE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286129.1 467958 D 155864 CDS NP_286130.1 15800118 957339 470384..470665 1 NC_002655.2 hypothetical protein 470665 957339 Z0489 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286130.1 470384 D 155864 CDS NP_286131.1 15800119 957340 470662..471111 1 NC_002655.2 No significant matches; hypothetical protein 471111 957340 Z0491 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286131.1 470662 D 155864 CDS NP_286132.1 15800120 957342 complement(471196..472107) 1 NC_002655.2 Required for efficient pilin antigenic variation; recombination associated protein 472107 rdgC 957342 rdgC Escherichia coli O157:H7 str. EDL933 recombination associated protein NP_286132.1 471196 R 155864 CDS NP_286133.2 161367641 957343 472232..473140 1 NC_002655.2 catalyzes phosphorylation of fructose; cytosolic enzyme; fructokinase 473140 yajF 957343 yajF Escherichia coli O157:H7 str. EDL933 fructokinase NP_286133.2 472232 D 155864 CDS NP_286134.1 15800122 957344 complement(473283..474467) 1 NC_002655.2 member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers; MFS transport protein AraJ 474467 araJ 957344 araJ Escherichia coli O157:H7 str. EDL933 MFS transport protein AraJ NP_286134.1 473283 R 155864 CDS NP_286135.1 15800123 957347 complement(474593..477736) 1 NC_002655.2 with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity; exonuclease SbcC 477736 sbcC 957347 sbcC Escherichia coli O157:H7 str. EDL933 exonuclease SbcC NP_286135.1 474593 R 155864 CDS NP_286136.1 15800124 957348 complement(477733..478935) 1 NC_002655.2 with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity; exonuclease SbcD 478935 sbcD 957348 sbcD Escherichia coli O157:H7 str. EDL933 exonuclease SbcD NP_286136.1 477733 R 155864 CDS NP_286137.1 15800125 957349 479125..479814 1 NC_002655.2 two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB; transcriptional regulator PhoB 479814 phoB 957349 phoB Escherichia coli O157:H7 str. EDL933 transcriptional regulator PhoB NP_286137.1 479125 D 155864 CDS NP_286138.1 15800126 957350 479872..481167 1 NC_002655.2 membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB; phosphate regulon sensor protein 481167 phoR 957350 phoR Escherichia coli O157:H7 str. EDL933 phosphate regulon sensor protein NP_286138.1 479872 D 155864 CDS NP_286139.1 15800127 957352 481574..482893 1 NC_002655.2 branched chain amino acid transport system II carrier protein 482893 brnQ 957352 brnQ Escherichia coli O157:H7 str. EDL933 branched chain amino acid transport system II carrier protein NP_286139.1 481574 D 155864 CDS NP_286140.1 15800128 957353 482969..484342 1 NC_002655.2 cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation; permease 484342 proY 957353 proY Escherichia coli O157:H7 str. EDL933 permease NP_286140.1 482969 D 155864 CDS NP_286141.1 15800129 957355 484498..486315 1 NC_002655.2 maltodextrin glucosidase 486315 malZ 957355 malZ Escherichia coli O157:H7 str. EDL933 maltodextrin glucosidase NP_286141.1 484498 D 155864 CDS NP_286142.1 15800130 957356 486503..487948 1 NC_002655.2 hypothetical protein 487948 957356 Z0502 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286142.1 486503 D 155864 CDS NP_286143.1 15800131 957357 complement(487969..488550) 1 NC_002655.2 Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; ACP phosphodieterase 488550 yajB 957357 yajB Escherichia coli O157:H7 str. EDL933 ACP phosphodieterase NP_286143.1 487969 R 155864 CDS NP_286144.1 15800132 957360 488643..489713 1 NC_002655.2 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 489713 queA 957360 queA Escherichia coli O157:H7 str. EDL933 S-adenosylmethionine--tRNA ribosyltransferase-isomerase NP_286144.1 488643 D 155864 CDS NP_286145.1 15800133 957361 489768..490895 1 NC_002655.2 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 490895 tgt 957361 tgt Escherichia coli O157:H7 str. EDL933 queuine tRNA-ribosyltransferase NP_286145.1 489768 D 155864 CDS NP_286146.1 15800134 957362 490918..491250 1 NC_002655.2 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 491250 yajC 957362 yajC Escherichia coli O157:H7 str. EDL933 preprotein translocase subunit YajC NP_286146.1 490918 D 155864 CDS NP_286147.1 15800135 957363 491278..493125 1 NC_002655.2 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 493125 secD 957363 secD Escherichia coli O157:H7 str. EDL933 preprotein translocase subunit SecD NP_286147.1 491278 D 155864 CDS NP_286148.1 15800136 957364 493136..494107 1 NC_002655.2 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 494107 secF 957364 secF Escherichia coli O157:H7 str. EDL933 preprotein translocase subunit SecF NP_286148.1 493136 D 155864 CDS NP_286149.1 15800137 957365 494258..494500 1 NC_002655.2 hypothetical protein 494500 957365 Z0509 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286149.1 494258 D 155864 CDS NP_286150.1 15800138 957367 494493..494774 1 NC_002655.2 hypothetical protein 494774 957367 Z0510 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286150.1 494493 D 155864 CDS NP_286151.1 15800139 957368 494862..495209 1 NC_002655.2 hypothetical protein 495209 yajD 957368 yajD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286151.1 494862 D 155864 CDS NP_286152.1 15800140 957370 complement(495386..496270) 1 NC_002655.2 nucleoside channel phage T6/colicin K receptor 496270 tsx 957370 tsx Escherichia coli O157:H7 str. EDL933 nucleoside channel phage T6/colicin K receptor NP_286152.1 495386 R 155864 CDS NP_286153.2 161367640 957371 complement(496569..497108) 1 NC_002655.2 hypothetical protein 497108 yajI 957371 yajI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286153.2 496569 R 155864 CDS NP_286154.1 15800142 957372 497259..497708 1 NC_002655.2 transcriptional regulator NrdR 497708 nrdR 957372 nrdR Escherichia coli O157:H7 str. EDL933 transcriptional regulator NrdR NP_286154.1 497259 D 155864 CDS NP_286155.1 15800143 957373 497712..498815 1 NC_002655.2 riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase 498815 ribD 957373 ribD Escherichia coli O157:H7 str. EDL933 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase NP_286155.1 497712 D 155864 CDS NP_286156.1 15800144 957375 498904..499374 1 NC_002655.2 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 499374 ribH 957375 ribH Escherichia coli O157:H7 str. EDL933 6,7-dimethyl-8-ribityllumazine synthase NP_286156.1 498904 D 155864 CDS NP_286157.1 15800145 957377 499394..499813 1 NC_002655.2 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 499813 nusB 957377 nusB Escherichia coli O157:H7 str. EDL933 transcription antitermination protein NusB NP_286157.1 499394 D 155864 CDS NP_286158.1 15800146 957378 499891..500868 1 NC_002655.2 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 500868 thiL 957378 thiL Escherichia coli O157:H7 str. EDL933 thiamine monophosphate kinase NP_286158.1 499891 D 155864 CDS NP_286159.1 15800147 957379 500846..501361 1 NC_002655.2 hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate; phosphatidylglycerophosphatase A 501361 pgpA 957379 pgpA Escherichia coli O157:H7 str. EDL933 phosphatidylglycerophosphatase A NP_286159.1 500846 D 155864 CDS NP_286160.1 15800148 957382 complement(501539..503110) 1 NC_002655.2 hypothetical protein 503110 957382 Z0521 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286160.1 501539 R 155864 CDS NP_286161.1 15800149 957383 complement(503341..504315) 1 NC_002655.2 NAD(P)H-dependent xylose reductase 504315 yajO 957383 yajO Escherichia coli O157:H7 str. EDL933 NAD(P)H-dependent xylose reductase NP_286161.1 503341 R 155864 CDS NP_286162.1 15800150 957384 complement(504370..506232) 1 NC_002655.2 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 506232 dxs 957384 dxs Escherichia coli O157:H7 str. EDL933 1-deoxy-D-xylulose-5-phosphate synthase NP_286162.1 504370 R 155864 CDS NP_286163.1 15800151 957385 complement(506257..507156) 1 NC_002655.2 geranyltranstransferase 507156 ispA 957385 ispA Escherichia coli O157:H7 str. EDL933 geranyltranstransferase NP_286163.1 506257 R 155864 CDS NP_286164.1 15800152 957387 complement(507156..507398) 1 NC_002655.2 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 507398 xseB 957387 xseB Escherichia coli O157:H7 str. EDL933 exodeoxyribonuclease VII small subunit NP_286164.1 507156 R 155864 CDS NP_286165.1 15800153 957389 507604..509052 1 NC_002655.2 Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 509052 yajK 957389 yajK Escherichia coli O157:H7 str. EDL933 thiamine biosynthesis protein ThiI NP_286165.1 507604 D 155864 CDS NP_286166.1 15800154 957392 complement(509106..509702) 1 NC_002655.2 DJ-1 family protein 509702 thiJ 957392 thiJ Escherichia coli O157:H7 str. EDL933 DJ-1 family protein NP_286166.1 509106 R 155864 CDS NP_286167.1 15800155 957394 complement(509659..510570) 1 NC_002655.2 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 510570 apbA 957394 apbA Escherichia coli O157:H7 str. EDL933 2-dehydropantoate 2-reductase NP_286167.1 509659 R 155864 CDS NP_286168.2 161367639 957395 510738..511229 1 NC_002655.2 nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; nucleotide-binding protein 511229 yajQ 957395 yajQ Escherichia coli O157:H7 str. EDL933 nucleotide-binding protein NP_286168.2 510738 D 155864 CDS NP_286169.1 15800157 957396 complement(511357..512727) 1 NC_002655.2 transporter 512727 yajR 957396 yajR Escherichia coli O157:H7 str. EDL933 transporter NP_286169.1 511357 R 155864 CDS NP_286170.1 15800158 957397 complement(512870..513760) 1 NC_002655.2 converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 513760 cyoE 957397 cyoE Escherichia coli O157:H7 str. EDL933 protoheme IX farnesyltransferase NP_286170.1 512870 R 155864 CDS NP_286171.1 15800159 957398 complement(513772..514101) 1 NC_002655.2 cytochrome o ubiquinol oxidase subunit IV 514101 cyoD 957398 cyoD Escherichia coli O157:H7 str. EDL933 cytochrome o ubiquinol oxidase subunit IV NP_286171.1 513772 R 155864 CDS NP_286172.1 15800160 957399 complement(514101..514715) 1 NC_002655.2 cytochrome o ubiquinol oxidase subunit III 514715 cyoC 957399 cyoC Escherichia coli O157:H7 str. EDL933 cytochrome o ubiquinol oxidase subunit III NP_286172.1 514101 R 155864 CDS NP_286173.1 15800161 957400 complement(514705..516696) 1 NC_002655.2 cytochrome o ubiquinol oxidase subunit I 516696 cyoB 957400 cyoB Escherichia coli O157:H7 str. EDL933 cytochrome o ubiquinol oxidase subunit I NP_286173.1 514705 R 155864 CDS NP_286174.1 15800162 957401 complement(516718..517665) 1 NC_002655.2 cytochrome o ubiquinol oxidase subunit II 517665 cyoA 957401 cyoA Escherichia coli O157:H7 str. EDL933 cytochrome o ubiquinol oxidase subunit II NP_286174.1 516718 R 155864 CDS NP_286175.1 15800163 957402 complement(518125..519600) 1 NC_002655.2 in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein; muropeptide transporter 519600 ampG 957402 ampG Escherichia coli O157:H7 str. EDL933 muropeptide transporter NP_286175.1 518125 R 155864 CDS NP_286176.2 161367638 957404 complement(519644..520222) 1 NC_002655.2 hypothetical protein 520222 yajG 957404 yajG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286176.2 519644 R 155864 CDS NP_286177.2 161367637 957405 520527..520844 1 NC_002655.2 positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress; transcriptional regulator BolA 520844 bolA 957405 bolA Escherichia coli O157:H7 str. EDL933 transcriptional regulator BolA NP_286177.2 520527 D 155864 CDS NP_286178.1 15800166 957406 521188..522486 1 NC_002655.2 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 522486 tig 957406 tig Escherichia coli O157:H7 str. EDL933 trigger factor NP_286178.1 521188 D 155864 CDS NP_286179.1 15800167 957407 522731..523354 1 NC_002655.2 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 523354 clpP 957407 clpP Escherichia coli O157:H7 str. EDL933 ATP-dependent Clp protease proteolytic subunit NP_286179.1 522731 D 155864 CDS NP_286180.1 15800168 957408 523480..524754 1 NC_002655.2 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 524754 clpX 957408 clpX Escherichia coli O157:H7 str. EDL933 ATP-dependent protease ATP-binding subunit ClpX NP_286180.1 523480 D 155864 CDS NP_286181.1 15800169 957409 524897..527296 1 NC_002655.2 DNA-binding ATP-dependent protease La 527296 lon 957409 lon Escherichia coli O157:H7 str. EDL933 DNA-binding ATP-dependent protease La NP_286181.1 524897 D 155864 CDS NP_286182.1 15800170 957410 527505..527777 1 NC_002655.2 histone-like DNA-binding protein; transcriptional regulator HU subunit beta 527777 hupB 957410 hupB Escherichia coli O157:H7 str. EDL933 transcriptional regulator HU subunit beta NP_286182.1 527505 D 155864 CDS NP_286183.1 15800171 957411 527969..529840 1 NC_002655.2 peptidyl-prolyl cis-trans isomerase 529840 ybaU 957411 ybaU Escherichia coli O157:H7 str. EDL933 peptidyl-prolyl cis-trans isomerase NP_286183.1 527969 D 155864 CDS NP_286184.1 15800172 957412 529992..530363 1 NC_002655.2 hypothetical protein 530363 ybaV 957412 ybaV Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286184.1 529992 D 155864 CDS NP_286185.1 15800173 957413 530469..530867 1 NC_002655.2 hypothetical protein 530867 ybaW 957413 ybaW Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286185.1 530469 D 155864 CDS NP_286186.1 15800174 957415 complement(530919..531614) 1 NC_002655.2 YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His; queuosine biosynthesis protein QueC 531614 ybaX 957415 ybaX Escherichia coli O157:H7 str. EDL933 queuosine biosynthesis protein QueC NP_286186.1 530919 R 155864 CDS NP_286187.1 15800175 957416 complement(531679..533379) 1 NC_002655.2 hypothetical protein 533379 ybaE 957416 ybaE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286187.1 531679 R 155864 CDS NP_286188.1 15800176 957417 533467..534297 1 NC_002655.2 hypothetical protein 534297 cof 957417 cof Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286188.1 533467 D 155864 CDS NP_286189.1 15800177 957418 534449..534907 1 NC_002655.2 transcriptional regulator 534907 ybaO 957418 ybaO Escherichia coli O157:H7 str. EDL933 transcriptional regulator NP_286189.1 534449 D 155864 CDS NP_286190.1 15800178 957419 534937..536709 1 NC_002655.2 multidrug transporter membrane\ATP-binding components 536709 mdlA 957419 mdlA Escherichia coli O157:H7 str. EDL933 multidrug transporter membrane\ATP-binding components NP_286190.1 534937 D 155864 CDS NP_286191.1 15800179 957421 536702..538483 1 NC_002655.2 multidrug transporter membrane\ATP-binding components 538483 mdlB 957421 mdlB Escherichia coli O157:H7 str. EDL933 multidrug transporter membrane\ATP-binding components NP_286191.1 536702 D 155864 CDS NP_286192.1 15800180 957422 538664..539002 1 NC_002655.2 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia.; nitrogen regulatory protein P-II 2 539002 glnK 957422 glnK Escherichia coli O157:H7 str. EDL933 nitrogen regulatory protein P-II 2 NP_286192.1 538664 D 155864 CDS NP_286193.1 15800181 957423 539032..540318 1 NC_002655.2 ammonium transporter 540318 amtB 957423 amtB Escherichia coli O157:H7 str. EDL933 ammonium transporter NP_286193.1 539032 D 155864 CDS NP_286194.1 15800182 957424 complement(540367..541227) 1 NC_002655.2 acyl-CoA thioesterase 541227 tesB 957424 tesB Escherichia coli O157:H7 str. EDL933 acyl-CoA thioesterase NP_286194.1 540367 R 155864 CDS NP_286195.1 15800183 957425 541445..542017 1 NC_002655.2 glycoprotein/polysaccharide metabolism 542017 ybaY 957425 ybaY Escherichia coli O157:H7 str. EDL933 glycoprotein/polysaccharide metabolism NP_286195.1 541445 D 155864 CDS NP_286196.1 15800184 957427 complement(542050..542421) 1 NC_002655.2 hypothetical protein 542421 ybaZ 957427 ybaZ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286196.1 542050 R 155864 CDS NP_286197.1 15800185 957429 542740..543093 1 NC_002655.2 hypothetical protein 543093 ybaA 957429 ybaA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286197.1 542740 D 155864 CDS NP_286198.1 15800186 957430 complement(543135..544691) 1 NC_002655.2 hypothetical protein 544691 ylaB 957430 ylaB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286198.1 543135 R 155864 CDS NP_286199.1 15800187 957431 complement(544849..545358) 1 NC_002655.2 hypothetical protein 545358 ylaC 957431 ylaC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286199.1 544849 R 155864 CDS NP_286200.1 15800188 957433 complement(545435..545986) 1 NC_002655.2 maltose O-acetyltransferase 545986 ylaD 957433 ylaD Escherichia coli O157:H7 str. EDL933 maltose O-acetyltransferase NP_286200.1 545435 R 155864 CDS NP_286201.1 15800189 957434 complement(546158..546376) 1 NC_002655.2 with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins; hemolysin expression-modulating protein 546376 hha 957434 hha Escherichia coli O157:H7 str. EDL933 hemolysin expression-modulating protein NP_286201.1 546158 R 155864 CDS NP_286202.1 15800190 957435 complement(546402..546776) 1 NC_002655.2 hypothetical protein 546776 ybaJ 957435 ybaJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286202.1 546402 R 155864 CDS NP_286203.1 15800191 957438 complement(547322..550471) 1 NC_002655.2 acridine efflux pump 550471 acrB 957438 acrB Escherichia coli O157:H7 str. EDL933 acridine efflux pump NP_286203.1 547322 R 155864 CDS NP_286204.1 15800192 957439 complement(550494..551687) 1 NC_002655.2 acridine efflux pump 551687 acrA 957439 acrA Escherichia coli O157:H7 str. EDL933 acridine efflux pump NP_286204.1 550494 R 155864 CDS NP_286205.1 15800193 957440 551829..552476 1 NC_002655.2 regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine; DNA-binding transcriptional repressor AcrR 552476 acrR 957440 acrR Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional repressor AcrR NP_286205.1 551829 D 155864 CDS NP_286206.1 15800194 957441 552604..555966 1 NC_002655.2 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA 555966 aefA 957441 aefA Escherichia coli O157:H7 str. EDL933 potassium efflux protein KefA NP_286206.1 552604 D 155864 CDS NP_286207.1 15800195 957442 complement(556005..556169) 1 NC_002655.2 hypothetical protein 556169 957442 Z0583 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286207.1 556005 R 155864 CDS NP_286208.1 15800196 957443 complement(556183..556710) 1 NC_002655.2 PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks; primosomal replication protein N'' 556710 priC 957443 priC Escherichia coli O157:H7 str. EDL933 primosomal replication protein N'' NP_286208.1 556183 R 155864 CDS NP_286209.1 15800197 957444 556780..557157 1 NC_002655.2 hypothetical protein 557157 ybaN 957444 ybaN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286209.1 556780 D 155864 CDS NP_286210.1 15800198 957445 557310..557861 1 NC_002655.2 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 557861 apt 957445 apt Escherichia coli O157:H7 str. EDL933 adenine phosphoribosyltransferase NP_286210.1 557310 D 155864 CDS NP_286211.1 15800199 957446 557990..559921 1 NC_002655.2 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 559921 dnaX 957446 dnaX Escherichia coli O157:H7 str. EDL933 DNA polymerase III subunits gamma and tau NP_286211.1 557990 D 155864 CDS NP_286212.1 15800200 957447 559974..560303 1 NC_002655.2 hypothetical protein 560303 ybaB 957447 ybaB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286212.1 559974 D 155864 CDS NP_286213.1 15800201 957448 560303..560908 1 NC_002655.2 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 560908 recR 957448 recR Escherichia coli O157:H7 str. EDL933 recombination protein RecR NP_286213.1 560303 D 155864 CDS NP_286214.1 15800202 957449 561018..562892 1 NC_002655.2 molecular chaperone; heat shock protein 90 562892 htpG 957449 htpG Escherichia coli O157:H7 str. EDL933 heat shock protein 90 NP_286214.1 561018 D 155864 CDS NP_286215.1 15800203 957450 563073..563717 1 NC_002655.2 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 563717 adk 957450 adk Escherichia coli O157:H7 str. EDL933 adenylate kinase NP_286215.1 563073 D 155864 CDS NP_286216.1 15800204 957451 563849..564811 1 NC_002655.2 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 564811 hemH 957451 hemH Escherichia coli O157:H7 str. EDL933 ferrochelatase NP_286216.1 563849 D 155864 CDS NP_286217.1 15800205 957452 complement(564808..565767) 1 NC_002655.2 acetyl esterase 565767 ybaC 957452 ybaC Escherichia coli O157:H7 str. EDL933 acetyl esterase NP_286217.1 564808 R 155864 CDS NP_286218.1 15800206 957453 565919..567223 1 NC_002655.2 inosine-guanosine kinase 567223 gsk 957453 gsk Escherichia coli O157:H7 str. EDL933 inosine-guanosine kinase NP_286218.1 565919 D 155864 CDS NP_286219.1 15800207 957454 complement(567356..569032) 1 NC_002655.2 YbaL; member of the CPA-2 family of antiporters; uncharacterized protein; cation:proton antiport protein 569032 ybaL 957454 ybaL Escherichia coli O157:H7 str. EDL933 cation:proton antiport protein NP_286219.1 567356 R 155864 CDS NP_286220.1 15800208 957455 complement(569269..570489) 1 NC_002655.2 fosmidomycin resistance protein 570489 fsr 957455 fsr Escherichia coli O157:H7 str. EDL933 fosmidomycin resistance protein NP_286220.1 569269 R 155864 CDS NP_286221.1 15800209 957456 570707..572359 1 NC_002655.2 catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic 572359 ushA 957456 ushA Escherichia coli O157:H7 str. EDL933 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic NP_286221.1 570707 D 155864 CDS NP_286222.1 15800210 957457 complement(572396..572875) 1 NC_002655.2 hypothetical protein 572875 ybaK 957457 ybaK Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286222.1 572396 R 155864 CDS NP_286223.1 15800211 957458 complement(573079..573873) 1 NC_002655.2 ligase 573873 ybaP 957458 ybaP Escherichia coli O157:H7 str. EDL933 ligase NP_286223.1 573079 R 155864 CDS NP_286224.1 15800212 957459 573957..574352 1 NC_002655.2 hypothetical protein 574352 ybaQ 957459 ybaQ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286224.1 573957 D 155864 CDS NP_286225.1 15800213 957460 complement(574567..577071) 1 NC_002655.2 copper exporting ATPase 577071 copA 957460 copA Escherichia coli O157:H7 str. EDL933 copper exporting ATPase NP_286225.1 574567 R 155864 CDS NP_286226.1 15800214 957462 577333..578265 1 NC_002655.2 catalyzes the formation of glutamate from glutamine; glutaminase 578265 ybaS 957462 ybaS Escherichia coli O157:H7 str. EDL933 glutaminase NP_286226.1 577333 D 155864 CDS NP_286227.1 15800215 957463 578268..579560 1 NC_002655.2 amino acid/amine transport protein 579560 ybaT 957463 ybaT Escherichia coli O157:H7 str. EDL933 amino acid/amine transport protein NP_286227.1 578268 D 155864 CDS NP_286228.1 15800216 957464 579898..581253 1 NC_002655.2 outer membrane export protein 581253 957464 Z0608 Escherichia coli O157:H7 str. EDL933 outer membrane export protein NP_286228.1 579898 D 155864 CDS NP_286229.1 15800217 957466 581356..585741 1 NC_002655.2 hypothetical protein 585741 957466 Z0609 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286229.1 581356 D 155864 CDS NP_286230.1 15800218 957468 585949..601515 1 NC_002655.2 RTX family exoprotein 601515 957468 Z0615 Escherichia coli O157:H7 str. EDL933 RTX family exoprotein NP_286230.1 585949 D 155864 CDS NP_286231.1 15800219 957469 601519..603681 1 NC_002655.2 hypothetical protein 603681 957469 Z0634 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286231.1 601519 D 155864 CDS NP_286232.1 15800220 957470 603678..604853 1 NC_002655.2 membrane spanning export protein 604853 957470 Z0635 Escherichia coli O157:H7 str. EDL933 membrane spanning export protein NP_286232.1 603678 D 155864 CDS NP_286233.1 15800221 957471 604925..605257 1 NC_002655.2 transcriptional regulator 605257 ybbI 957471 ybbI Escherichia coli O157:H7 str. EDL933 transcriptional regulator NP_286233.1 604925 D 155864 CDS NP_286234.1 15800222 957473 complement(605461..605883) 1 NC_002655.2 No significant matches; hypothetical protein 605883 957473 Z0638 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286234.1 605461 R 155864 CDS NP_286235.1 15800223 957474 complement(605968..606984) 1 NC_002655.2 hypothetical protein 606984 957474 Z0639 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286235.1 605968 R 155864 CDS NP_286236.1 15800224 957475 607351..607713 1 NC_002655.2 No significant matches; hypothetical protein 607713 957475 Z0640 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286236.1 607351 D 155864 CDS NP_286237.1 15800225 957476 complement(607892..608350) 1 NC_002655.2 hypothetical protein 608350 ybbJ 957476 ybbJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286237.1 607892 R 155864 CDS NP_286238.1 15800226 957477 complement(608347..609264) 1 NC_002655.2 protease 609264 ybbK 957477 ybbK Escherichia coli O157:H7 str. EDL933 protease NP_286238.1 608347 R 155864 CDS NP_286239.1 15800227 957478 609410..610087 1 NC_002655.2 ABC transporter ATP-binding protein 610087 ybbL 957478 ybbL Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_286239.1 609410 D 155864 CDS NP_286240.1 15800228 957479 610047..610853 1 NC_002655.2 metal resistance protein 610853 ybbM 957479 ybbM Escherichia coli O157:H7 str. EDL933 metal resistance protein NP_286240.1 610047 D 155864 CDS NP_286241.1 15800229 957481 complement(610916..611806) 1 NC_002655.2 thioredoxin-like protein 611806 ybbN 957481 ybbN Escherichia coli O157:H7 str. EDL933 thioredoxin-like protein NP_286241.1 610916 R 155864 CDS NP_286242.1 15800230 957483 complement(611831..612640) 1 NC_002655.2 short chain dehydrogenase 612640 ybbO 957483 ybbO Escherichia coli O157:H7 str. EDL933 short chain dehydrogenase NP_286242.1 611831 R 155864 CDS NP_286243.1 15800231 957484 complement(612630..613256) 1 NC_002655.2 multifunctional acyl-CoA thioesterase I/protease I/lysophospholipase L1 613256 tesA 957484 tesA Escherichia coli O157:H7 str. EDL933 multifunctional acyl-CoA thioesterase I/protease I/lysophospholipase L1 NP_286243.1 612630 R 155864 CDS NP_286244.1 15800232 957485 613224..613910 1 NC_002655.2 ABC transporter ATP-binding protein 613910 ybbA 957485 ybbA Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_286244.1 613224 D 155864 CDS NP_286245.1 15800233 957486 613907..616321 1 NC_002655.2 oxidoreductase 616321 ybbP 957486 ybbP Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_286245.1 613907 D 155864 CDS NP_286246.1 15800234 957487 616751..620947 1 NC_002655.2 hypothetical protein 620947 957487 Z0651 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286246.1 616751 D 155864 CDS NP_286247.1 15800235 957488 620928..621188 1 NC_002655.2 hypothetical protein 621188 ybbD 957488 ybbD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286247.1 620928 D 155864 CDS NP_286248.1 15800236 957489 621227..621376 1 NC_002655.2 hypothetical protein 621376 957489 Z0654 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286248.1 621227 D 155864 CDS NP_286249.1 15800237 957491 complement(621371..621523) 1 NC_002655.2 No significant matches; hypothetical protein 621523 957491 Z0655 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286249.1 621371 R 155864 CDS NP_286250.1 15800238 957492 complement(621932..622339) 1 NC_002655.2 hypothetical protein 622339 957492 Z0656 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286250.1 621932 R 155864 CDS NP_286251.1 15800239 957493 complement(622419..623513) 1 NC_002655.2 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA; tRNA 2-selenouridine synthase 623513 ybbB 957493 ybbB Escherichia coli O157:H7 str. EDL933 tRNA 2-selenouridine synthase NP_286251.1 622419 R 155864 CDS NP_286252.1 15800240 957494 complement(623582..624508) 1 NC_002655.2 activator of the allDC-ylbA operon involved in allantoin utilization; DNA-binding transcriptional activator AllS 624508 ybbS 957494 ybbS Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional activator AllS NP_286252.1 623582 R 155864 CDS NP_286253.1 15800241 957495 624738..625220 1 NC_002655.2 catalyzes the formation of glyoxylate from (S)-ureidoglycolate; ureidoglycolate hydrolase 625220 ybbT 957495 ybbT Escherichia coli O157:H7 str. EDL933 ureidoglycolate hydrolase NP_286253.1 624738 D 155864 CDS NP_286254.1 15800242 957496 625298..626113 1 NC_002655.2 regulates operons involved in the utilization of allantoin; DNA-binding transcriptional repressor AllR 626113 ybbU 957496 ybbU Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional repressor AllR NP_286254.1 625298 D 155864 CDS NP_286255.1 15800243 957497 626203..627984 1 NC_002655.2 catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate; glyoxylate carboligase 627984 gcl 957497 gcl Escherichia coli O157:H7 str. EDL933 glyoxylate carboligase NP_286255.1 626203 D 155864 CDS NP_286256.1 15800244 957498 627997..628773 1 NC_002655.2 hydroxypyruvate isomerase 628773 gip 957498 gip Escherichia coli O157:H7 str. EDL933 hydroxypyruvate isomerase NP_286256.1 627997 D 155864 CDS NP_286257.1 15800245 957501 628874..629752 1 NC_002655.2 oxidoreductase 629752 ybbQ 957501 ybbQ Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_286257.1 628874 D 155864 CDS NP_286258.1 15800246 957502 629784..630062 1 NC_002655.2 hypothetical protein 630062 ybbV 957502 ybbV Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286258.1 629784 D 155864 CDS NP_286259.1 15800247 957507 629921..631312 1 NC_002655.2 allantoin permease 631312 957507 Z0665 Escherichia coli O157:H7 str. EDL933 allantoin permease NP_286259.1 629921 D 155864 CDS NP_286260.1 15800248 957508 631349..632239 1 NC_002655.2 Plays a crucial role on both purine and pyrimidine metabolism; allantoinase 632239 957508 Z0666 Escherichia coli O157:H7 str. EDL933 allantoinase NP_286260.1 631349 D 155864 CDS NP_286261.1 15800249 957509 632246..632710 1 NC_002655.2 hypothetical protein 632710 957509 Z0667 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286261.1 632246 D 155864 CDS NP_286262.1 15800250 957511 632761..634068 1 NC_002655.2 purine permease YbbY 634068 ybbY 957511 ybbY Escherichia coli O157:H7 str. EDL933 purine permease YbbY NP_286262.1 632761 D 155864 CDS NP_286263.1 15800251 957512 634090..635235 1 NC_002655.2 glycerate kinase 635235 ybbZ 957512 ybbZ Escherichia coli O157:H7 str. EDL933 glycerate kinase NP_286263.1 634090 D 155864 CDS NP_286264.1 15800252 957514 complement(635463..636248) 1 NC_002655.2 hypothetical protein 636248 ylbA 957514 ylbA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286264.1 635463 R 155864 CDS NP_286265.1 15800253 957515 complement(636259..637494) 1 NC_002655.2 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide; allantoate amidohydrolase 637494 ylbB 957515 ylbB Escherichia coli O157:H7 str. EDL933 allantoate amidohydrolase NP_286265.1 636259 R 155864 CDS NP_286266.1 15800254 957518 complement(637516..638565) 1 NC_002655.2 malate dehydrogenase 638565 ylbC 957518 ylbC Escherichia coli O157:H7 str. EDL933 malate dehydrogenase NP_286266.1 637516 R 155864 CDS NP_286267.1 15800255 957519 638882..640549 1 NC_002655.2 multicopy suppressor of dominant negative ftsH mutations; membrane protein FdrA 640549 fdrA 957519 fdrA Escherichia coli O157:H7 str. EDL933 membrane protein FdrA NP_286267.1 638882 D 155864 CDS NP_286268.1 15800256 957521 640817..641818 1 NC_002655.2 hypothetical protein 641818 ylbE 957521 ylbE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286268.1 640817 D 155864 CDS NP_286269.1 15800257 957522 641829..642644 1 NC_002655.2 carboxylase 642644 ylbF 957522 ylbF Escherichia coli O157:H7 str. EDL933 carboxylase NP_286269.1 641829 D 155864 CDS NP_286270.1 15800258 957524 642641..643534 1 NC_002655.2 forms a homodimer; may be used to synthesize carbomyl phosphate from ATP and carbamate; carbamate kinase 643534 arcC 957524 arcC Escherichia coli O157:H7 str. EDL933 carbamate kinase NP_286270.1 642641 D 155864 CDS NP_286271.1 15800259 957525 complement(643673..644740) 1 NC_002655.2 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 644740 purK 957525 purK Escherichia coli O157:H7 str. EDL933 phosphoribosylaminoimidazole carboxylase ATPase subunit NP_286271.1 643673 R 155864 CDS NP_286272.1 15800260 957530 complement(644737..645246) 1 NC_002655.2 Catalyzes a step in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase catalytic subunit 645246 purE 957530 purE Escherichia coli O157:H7 str. EDL933 phosphoribosylaminoimidazole carboxylase catalytic subunit NP_286272.1 644737 R 155864 CDS NP_286273.1 15800261 957532 complement(645364..646086) 1 NC_002655.2 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase 646086 ybbF 957532 ybbF Escherichia coli O157:H7 str. EDL933 UDP-2,3-diacylglucosamine hydrolase NP_286273.1 645364 R 155864 CDS NP_286274.1 15800262 957533 complement(646089..646583) 1 NC_002655.2 peptidyl-prolyl cis-trans isomerase B 646583 ppiB 957533 ppiB Escherichia coli O157:H7 str. EDL933 peptidyl-prolyl cis-trans isomerase B NP_286274.1 646089 R 155864 CDS NP_286275.1 15800263 957534 646757..648142 1 NC_002655.2 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 648142 cysS 957534 cysS Escherichia coli O157:H7 str. EDL933 cysteinyl-tRNA synthetase NP_286275.1 646757 D 155864 CDS NP_286276.1 15800264 957535 complement(648178..648699) 1 NC_002655.2 hypothetical protein 648699 ybcI 957535 ybcI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286276.1 648178 R 155864 CDS NP_286277.2 161367636 957536 complement(648807..649019) 1 NC_002655.2 hypothetical protein 649019 ybcJ 957536 ybcJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286277.2 648807 R 155864 CDS NP_286278.1 15800266 957537 complement(649021..649887) 1 NC_002655.2 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 649887 folD 957537 folD Escherichia coli O157:H7 str. EDL933 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase NP_286278.1 649021 R 155864 CDS NP_286279.1 15800267 957538 650325..650900 1 NC_002655.2 fimbrial-like protein 650900 sfmA 957538 sfmA Escherichia coli O157:H7 str. EDL933 fimbrial-like protein NP_286279.1 650325 D 155864 CDS NP_286280.1 15800268 957539 651120..651812 1 NC_002655.2 chaperone 651812 sfmC 957539 sfmC Escherichia coli O157:H7 str. EDL933 chaperone NP_286280.1 651120 D 155864 CDS NP_286281.1 15800269 957540 651843..654452 1 NC_002655.2 hypothetical protein 654452 sfmD 957540 sfmD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286281.1 651843 D 155864 CDS NP_286282.1 15800270 957543 654495..655472 1 NC_002655.2 fimbrial asembly protein 655472 sfmH 957543 sfmH Escherichia coli O157:H7 str. EDL933 fimbrial asembly protein NP_286282.1 654495 D 155864 CDS NP_286283.1 15800271 957544 655483..655998 1 NC_002655.2 fimbrial protein 655998 sfmF 957544 sfmF Escherichia coli O157:H7 str. EDL933 fimbrial protein NP_286283.1 655483 D 155864 CDS NP_286284.1 15800272 957547 complement(656001..656696) 1 NC_002655.2 activates the production of the major fimbrae protein FimA; transcriptional regulator FimZ 656696 fimZ 957547 fimZ Escherichia coli O157:H7 str. EDL933 transcriptional regulator FimZ NP_286284.1 656001 R 155864 CDS NP_286285.1 15800273 957551 complement(656998..657759) 1 NC_002655.2 envelope protein; thermoregulation of porin biosynthesis 657759 envY 957551 envY Escherichia coli O157:H7 str. EDL933 envelope protein; thermoregulation of porin biosynthesis NP_286285.1 656998 R 155864 CDS NP_286286.1 15800274 957552 complement(657942..658832) 1 NC_002655.2 hypothetical protein 658832 ybcH 957552 ybcH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286286.1 657942 R 155864 CDS NP_286287.1 15800275 957554 complement(658833..661805) 1 NC_002655.2 bacteriophage N4 receptor, outer membrane subunit 661805 nfrA 957554 nfrA Escherichia coli O157:H7 str. EDL933 bacteriophage N4 receptor, outer membrane subunit NP_286287.1 658833 R 155864 CDS NP_286288.1 15800276 957558 complement(661792..664029) 1 NC_002655.2 bacteriophage N4 adsorption protein B 664029 nfrB 957558 nfrB Escherichia coli O157:H7 str. EDL933 bacteriophage N4 adsorption protein B NP_286288.1 661792 R 155864 CDS NP_286289.1 15800277 957559 complement(664295..665431) 1 NC_002655.2 receptor 665431 957559 Z0700 Escherichia coli O157:H7 str. EDL933 receptor NP_286289.1 664295 R 155864 CDS NP_286290.1 15800278 957560 complement(665646..665867) 1 NC_002655.2 No significant matches; hypothetical protein 665867 957560 Z0701 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286290.1 665646 R 155864 CDS NP_286291.1 15800279 957562 complement(665894..667228) 1 NC_002655.2 hypothetical protein 667228 957562 Z0702 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286291.1 665894 R 155864 CDS NP_286292.1 15800280 957563 complement(667823..672760) 1 NC_002655.2 hypothetical protein 672760 957563 Z0705 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286292.1 667823 R 155864 CDS NP_286293.1 15800281 957564 complement(672780..673241) 1 NC_002655.2 No significant matches; hypothetical protein 673241 957564 Z0706 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286293.1 672780 R 155864 CDS NP_286294.1 15800282 957565 complement(673269..675170) 1 NC_002655.2 hypothetical protein 675170 957565 Z0707 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286294.1 673269 R 155864 CDS NP_286295.1 15800283 957566 complement(675764..677212) 1 NC_002655.2 sensor kinase CusS 677212 ybcZ 957566 ybcZ Escherichia coli O157:H7 str. EDL933 sensor kinase CusS NP_286295.1 675764 R 155864 CDS NP_286296.1 15800284 957567 complement(677202..677885) 1 NC_002655.2 response regulator in two-component regulatory system with CusS; regulates the copper efflux system; DNA-binding transcriptional activator CusR 677885 ylcA 957567 ylcA Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional activator CusR NP_286296.1 677202 R 155864 CDS NP_286297.1 15800285 957569 678042..679424 1 NC_002655.2 with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system outer membrane protein CusC 679424 ylcB 957569 ylcB Escherichia coli O157:H7 str. EDL933 copper/silver efflux system outer membrane protein CusC NP_286297.1 678042 D 155864 CDS NP_286298.1 15800286 957570 679448..679780 1 NC_002655.2 copper-binding protein 679780 ylcC 957570 ylcC Escherichia coli O157:H7 str. EDL933 copper-binding protein NP_286298.1 679448 D 155864 CDS NP_286299.1 15800287 957571 679796..681019 1 NC_002655.2 with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system membrane fusion protein CusB 681019 ylcD 957571 ylcD Escherichia coli O157:H7 str. EDL933 copper/silver efflux system membrane fusion protein CusB NP_286299.1 679796 D 155864 CDS NP_286300.1 15800288 957572 681031..684168 1 NC_002655.2 inner membrane component for iron transport 684168 ybdE 957572 ybdE Escherichia coli O157:H7 str. EDL933 inner membrane component for iron transport NP_286300.1 681031 D 155864 CDS NP_286301.1 15800289 957574 684270..685646 1 NC_002655.2 phenylalanine transporter 685646 pheP 957574 pheP Escherichia coli O157:H7 str. EDL933 phenylalanine transporter NP_286301.1 684270 D 155864 CDS NP_286302.1 15800290 957575 complement(685714..686961) 1 NC_002655.2 transport 686961 ybdG 957575 ybdG Escherichia coli O157:H7 str. EDL933 transport NP_286302.1 685714 R 155864 CDS NP_286303.1 15800291 957577 complement(687069..687722) 1 NC_002655.2 catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase 687722 nfnB 957577 nfnB Escherichia coli O157:H7 str. EDL933 dihydropteridine reductase NP_286303.1 687069 R 155864 CDS NP_286304.1 15800292 957578 complement(687816..688184) 1 NC_002655.2 hypothetical protein 688184 ybdF 957578 ybdF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286304.1 687816 R 155864 CDS NP_286305.1 15800293 957580 complement(688249..688497) 1 NC_002655.2 hypothetical protein 688497 ybdJ 957580 ybdJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286305.1 688249 R 155864 CDS NP_286306.1 15800294 957581 complement(688563..689681) 1 NC_002655.2 ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity; carboxylate-amine ligase 689681 ybdK 957581 ybdK Escherichia coli O157:H7 str. EDL933 carboxylate-amine ligase NP_286306.1 688563 R 155864 CDS NP_286307.1 15800295 957586 689976..690272 1 NC_002655.2 hypothetical protein 690272 957586 Z0721 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286307.1 689976 D 155864 CDS NP_286308.1 15800296 957587 690524..690775 1 NC_002655.2 hypothetical protein 690775 957587 Z0722 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286308.1 690524 D 155864 CDS NP_286309.1 15800297 957588 complement(690897..691526) 1 NC_002655.2 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex 691526 entD 957588 entD Escherichia coli O157:H7 str. EDL933 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex NP_286309.1 690897 R 155864 CDS NP_286310.1 15800298 957590 complement(691692..693932) 1 NC_002655.2 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space; outer membrane receptor FepA 693932 fepA 957590 fepA Escherichia coli O157:H7 str. EDL933 outer membrane receptor FepA NP_286310.1 691692 R 155864 CDS NP_286311.1 15800299 957591 694253..695377 1 NC_002655.2 enterobactin/ferric enterobactin esterase 695377 fes 957591 fes Escherichia coli O157:H7 str. EDL933 enterobactin/ferric enterobactin esterase NP_286311.1 694253 D 155864 CDS NP_286312.1 15800300 957592 695380..695598 1 NC_002655.2 No significant matches; hypothetical protein 695598 957592 Z0726 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286312.1 695380 D 155864 CDS NP_286313.1 15800301 957595 695595..699476 1 NC_002655.2 with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin; enterobactin synthase subunit F 699476 entF 957595 entF Escherichia coli O157:H7 str. EDL933 enterobactin synthase subunit F NP_286313.1 695595 D 155864 CDS NP_286314.1 15800302 957597 699692..700825 1 NC_002655.2 part of the ferric enterobactin transport system; necessary for enetrobactin uptake; ferric enterobactin transport protein FepE 700825 fepE 957597 fepE Escherichia coli O157:H7 str. EDL933 ferric enterobactin transport protein FepE NP_286314.1 699692 D 155864 CDS NP_286315.1 15800303 957599 complement(700822..701637) 1 NC_002655.2 with FepBDE is involved in the transport of ferric enterobactin; iron-enterobactin transporter ATP-binding protein 701637 fepC 957599 fepC Escherichia coli O157:H7 str. EDL933 iron-enterobactin transporter ATP-binding protein NP_286315.1 700822 R 155864 CDS NP_286316.1 15800304 957600 complement(701634..702626) 1 NC_002655.2 with FepBCD is involved in the transport of ferric enterobactin; iron-enterobactin transporter permease 702626 fepG 957600 fepG Escherichia coli O157:H7 str. EDL933 iron-enterobactin transporter permease NP_286316.1 701634 R 155864 CDS NP_286317.1 15800305 957601 complement(702623..703627) 1 NC_002655.2 with FepBCG is involved in the transport of ferric enterobactin; iron-enterobactin transporter membrane protein 703627 fepD 957601 fepD Escherichia coli O157:H7 str. EDL933 iron-enterobactin transporter membrane protein NP_286317.1 702623 R 155864 CDS NP_286318.1 15800306 957603 703738..704988 1 NC_002655.2 protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters; enterobactin exporter EntS 704988 ybdA 957603 ybdA Escherichia coli O157:H7 str. EDL933 enterobactin exporter EntS NP_286318.1 703738 D 155864 CDS NP_286319.1 15800307 957604 complement(704992..705948) 1 NC_002655.2 with FepCDG is involved in the transport of ferric enterobactin; iron-enterobactin transporter periplasmic binding protein 705948 fepB 957604 fepB Escherichia coli O157:H7 str. EDL933 iron-enterobactin transporter periplasmic binding protein NP_286319.1 704992 R 155864 CDS NP_286320.1 15800308 957607 706137..707312 1 NC_002655.2 synthesizes isochorismate acid from chorismate; isochorismate synthase 707312 entC 957607 entC Escherichia coli O157:H7 str. EDL933 isochorismate synthase NP_286320.1 706137 D 155864 CDS NP_286321.1 15800309 957608 707322..708932 1 NC_002655.2 bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate; enterobactin synthase subunit E 708932 entE 957608 entE Escherichia coli O157:H7 str. EDL933 enterobactin synthase subunit E NP_286321.1 707322 D 155864 CDS NP_286322.1 15800310 957609 708946..709803 1 NC_002655.2 2,3-dihydro-2,3-dihydroxybenzoate synthetase 709803 entB 957609 entB Escherichia coli O157:H7 str. EDL933 2,3-dihydro-2,3-dihydroxybenzoate synthetase NP_286322.1 708946 D 155864 CDS NP_286323.1 15800311 957611 709803..710549 1 NC_002655.2 catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin; 2,3-dihydroxybenzoate-2,3-dehydrogenase 710549 entA 957611 entA Escherichia coli O157:H7 str. EDL933 2,3-dihydroxybenzoate-2,3-dehydrogenase NP_286323.1 709803 D 155864 CDS NP_286324.1 15800312 957613 710552..710965 1 NC_002655.2 hypothetical protein 710965 ybdB 957613 ybdB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286324.1 710552 D 155864 CDS NP_286325.1 15800313 957614 711146..713251 1 NC_002655.2 carbon starvation protein 713251 cstA 957614 cstA Escherichia coli O157:H7 str. EDL933 carbon starvation protein NP_286325.1 711146 D 155864 CDS NP_286326.1 15800314 957615 complement(713640..714728) 1 NC_002655.2 member of the iron-containing alcohol dehydrogenase; unknown function; hypothetical protein 714728 ybdH 957615 ybdH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286326.1 713640 R 155864 CDS NP_286327.1 15800315 957617 714837..715997 1 NC_002655.2 catalyzes the transfer of an amino moiety; aminotransferase 715997 ybdL 957617 ybdL Escherichia coli O157:H7 str. EDL933 aminotransferase NP_286327.1 714837 D 155864 CDS NP_286328.1 15800316 957619 complement(715998..716627) 1 NC_002655.2 hypothetical protein 716627 ybdM 957619 ybdM Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286328.1 715998 R 155864 CDS NP_286329.1 15800317 957620 complement(716600..717820) 1 NC_002655.2 hypothetical protein 717820 ybdN 957620 ybdN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286329.1 716600 R 155864 CDS NP_286330.1 15800318 957621 complement(717967..718869) 1 NC_002655.2 LysR family transcriptional regulator 718869 ybdO 957621 ybdO Escherichia coli O157:H7 str. EDL933 LysR family transcriptional regulator NP_286330.1 717967 R 155864 CDS NP_286331.2 161367635 957624 complement(719079..719825) 1 NC_002655.2 Involved in disulfide bond formation; disulfide isomerase/thiol-disulfide oxidase 719825 dsbG 957624 dsbG Escherichia coli O157:H7 str. EDL933 disulfide isomerase/thiol-disulfide oxidase NP_286331.2 719079 R 155864 CDS NP_286332.1 15800320 957626 720197..720760 1 NC_002655.2 with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate; alkyl hydroperoxide reductase 720760 ahpC 957626 ahpC Escherichia coli O157:H7 str. EDL933 alkyl hydroperoxide reductase NP_286332.1 720197 D 155864 CDS NP_286333.1 15800321 957628 720859..722454 1 NC_002655.2 alkyl hydroperoxide reductase 722454 ahpF 957628 ahpF Escherichia coli O157:H7 str. EDL933 alkyl hydroperoxide reductase NP_286333.1 720859 D 155864 CDS NP_286334.1 15800322 957630 complement(722575..723003) 1 NC_002655.2 hypothetical protein 723003 ybdQ 957630 ybdQ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286334.1 722575 R 155864 CDS NP_286335.1 15800323 957631 723224..724462 1 NC_002655.2 oxidoreductase 724462 ybdR 957631 ybdR Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_286335.1 723224 D 155864 CDS NP_286336.1 15800324 957632 724543..725004 1 NC_002655.2 hypothetical protein 725004 957632 Z0753 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286336.1 724543 D 155864 CDS NP_286337.1 15800325 957633 complement(724693..725103) 1 NC_002655.2 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator 725103 rnk 957633 rnk Escherichia coli O157:H7 str. EDL933 nucleoside diphosphate kinase regulator NP_286337.1 724693 R 155864 CDS NP_286338.1 15800326 957635 complement(725333..726139) 1 NC_002655.2 ribonuclease I 726139 rna 957635 rna Escherichia coli O157:H7 str. EDL933 ribonuclease I NP_286338.1 725333 R 155864 CDS NP_286339.1 15800327 957636 complement(726253..727716) 1 NC_002655.2 hypothetical protein 727716 ybdS 957636 ybdS Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286339.1 726253 R 155864 CDS NP_286340.1 15800328 957638 complement(727767..728645) 1 NC_002655.2 catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA; triphosphoribosyl-dephospho-CoA synthase 728645 citG 957638 citG Escherichia coli O157:H7 str. EDL933 triphosphoribosyl-dephospho-CoA synthase NP_286340.1 727767 R 155864 CDS NP_286341.1 15800329 957639 complement(728620..729171) 1 NC_002655.2 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate; 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase 729171 citX 957639 citX Escherichia coli O157:H7 str. EDL933 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase NP_286341.1 728620 R 155864 CDS NP_286342.1 15800330 957640 complement(729175..730707) 1 NC_002655.2 citrate lyase subunit alpha 730707 citF 957640 citF Escherichia coli O157:H7 str. EDL933 citrate lyase subunit alpha NP_286342.1 729175 R 155864 CDS NP_286343.1 15800331 957644 complement(730718..731641) 1 NC_002655.2 citrate lyase subunit beta 731641 citE 957644 citE Escherichia coli O157:H7 str. EDL933 citrate lyase subunit beta NP_286343.1 730718 R 155864 CDS NP_286344.1 15800332 957645 complement(731623..731919) 1 NC_002655.2 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma 731919 citD 957645 citD Escherichia coli O157:H7 str. EDL933 citrate lyase subunit gamma NP_286344.1 731623 R 155864 CDS NP_286345.1 15800333 957647 complement(731934..733079) 1 NC_002655.2 citrate lyase synthetase 733079 citC 957647 citC Escherichia coli O157:H7 str. EDL933 citrate lyase synthetase NP_286345.1 731934 R 155864 CDS NP_286346.1 15800334 957648 733372..735030 1 NC_002655.2 sensor-type protein 735030 citA 957648 citA Escherichia coli O157:H7 str. EDL933 sensor-type protein NP_286346.1 733372 D 155864 CDS NP_286347.1 15800335 957649 734999..735679 1 NC_002655.2 regulates the expression of citAB in citrate fermentation; two-component response regulator DpiA 735679 dpiA 957649 dpiA Escherichia coli O157:H7 str. EDL933 two-component response regulator DpiA NP_286347.1 734999 D 155864 CDS NP_286348.1 15800336 957650 complement(735720..737105) 1 NC_002655.2 responsible for the transport of C4-dicarboxylates during anaerobic growth; C4-dicarboxylate transporter DcuC 737105 dcuC 957650 dcuC Escherichia coli O157:H7 str. EDL933 C4-dicarboxylate transporter DcuC NP_286348.1 735720 R 155864 CDS NP_286349.1 15800337 957652 737694..738254 1 NC_002655.2 catalyzes the transfer of palmitate to lipid A; palmitoyl transferase 738254 pagP 957652 pagP Escherichia coli O157:H7 str. EDL933 palmitoyl transferase NP_286349.1 737694 D 155864 CDS NP_286350.1 15800338 957654 738429..738638 1 NC_002655.2 member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator; cold shock protein CspE 738638 cspE 957654 cspE Escherichia coli O157:H7 str. EDL933 cold shock protein CspE NP_286350.1 738429 D 155864 CDS NP_286351.1 15800339 957655 complement(738691..739074) 1 NC_002655.2 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 739074 ccrB 957655 ccrB Escherichia coli O157:H7 str. EDL933 camphor resistance protein CrcB NP_286351.1 738691 R 155864 CDS NP_286352.1 15800340 957658 739392..739955 1 NC_002655.2 hypothetical protein 739955 ybeM 957658 ybeM Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286352.1 739392 D 155864 CDS NP_286353.1 15800341 957659 740084..740287 1 NC_002655.2 TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase E 740287 tatE 957659 tatE Escherichia coli O157:H7 str. EDL933 twin arginine translocase E NP_286353.1 740084 D 155864 CDS NP_286354.1 15800342 957660 complement(740388..741353) 1 NC_002655.2 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 741353 lipA 957660 lipA Escherichia coli O157:H7 str. EDL933 lipoyl synthase NP_286354.1 740388 R 155864 CDS NP_286355.1 15800343 957661 complement(741562..742362) 1 NC_002655.2 DNA-binding transcriptional regulator 742362 ybeF 957661 ybeF Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator NP_286355.1 741562 R 155864 CDS NP_286356.2 161367634 957662 complement(742775..743416) 1 NC_002655.2 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 743416 lipB 957662 lipB Escherichia coli O157:H7 str. EDL933 lipoate-protein ligase B NP_286356.2 742775 R 155864 CDS NP_286357.1 15800345 957666 complement(743517..743780) 1 NC_002655.2 hypothetical protein 743780 ybeD 957666 ybeD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286357.1 743517 R 155864 CDS NP_286358.1 15800346 957671 complement(743890..745101) 1 NC_002655.2 penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; D-alanyl-D-alanine carboxypeptidase 745101 dacA 957671 dacA Escherichia coli O157:H7 str. EDL933 D-alanyl-D-alanine carboxypeptidase NP_286358.1 743890 R 155864 CDS NP_286359.1 15800347 957673 complement(745241..746329) 1 NC_002655.2 rare lipoprotein A 746329 rlpA 957673 rlpA Escherichia coli O157:H7 str. EDL933 rare lipoprotein A NP_286359.1 745241 R 155864 CDS NP_286360.1 15800348 957677 complement(746340..747452) 1 NC_002655.2 cell wall shape-determining protein 747452 mrdB 957677 mrdB Escherichia coli O157:H7 str. EDL933 cell wall shape-determining protein NP_286360.1 746340 R 155864 CDS NP_286361.1 15800349 957678 complement(747455..749356) 1 NC_002655.2 penicillin-binding protein 2 749356 mrdA 957678 mrdA Escherichia coli O157:H7 str. EDL933 penicillin-binding protein 2 NP_286361.1 747455 R 155864 CDS NP_286362.1 15800350 957681 complement(749387..749854) 1 NC_002655.2 SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 749854 ybeA 957681 ybeA Escherichia coli O157:H7 str. EDL933 rRNA large subunit methyltransferase NP_286362.1 749387 R 155864 CDS NP_286363.1 15800351 957683 complement(749858..750067) 1 NC_002655.2 hypothetical protein 750067 ybeB 957683 ybeB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286363.1 749858 R 155864 CDS NP_286364.1 15800352 957685 complement(750435..751046) 1 NC_002655.2 alpha-ribazole-5'-phosphate phosphatase 751046 phpB 957685 phpB Escherichia coli O157:H7 str. EDL933 alpha-ribazole-5'-phosphate phosphatase NP_286364.1 750435 R 155864 CDS NP_286365.1 15800353 957686 complement(751070..751711) 1 NC_002655.2 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 751711 nadD 957686 nadD Escherichia coli O157:H7 str. EDL933 nicotinic acid mononucleotide adenylyltransferase NP_286365.1 751070 R 155864 CDS NP_286366.1 15800354 957687 complement(751713..752744) 1 NC_002655.2 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 752744 holA 957687 holA Escherichia coli O157:H7 str. EDL933 DNA polymerase III subunit delta NP_286366.1 751713 R 155864 CDS NP_286367.1 15800355 957688 complement(752744..753325) 1 NC_002655.2 rare lipoprotein B; involved in the assembly of LPS in the outer membrane; LPS-assembly lipoprotein RlpB 753325 rlpB 957688 rlpB Escherichia coli O157:H7 str. EDL933 LPS-assembly lipoprotein RlpB NP_286367.1 752744 R 155864 CDS NP_286368.1 15800356 957690 complement(753340..755922) 1 NC_002655.2 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 755922 leuS 957690 leuS Escherichia coli O157:H7 str. EDL933 leucyl-tRNA synthetase NP_286368.1 753340 R 155864 CDS NP_286369.1 15800357 957694 756158..756640 1 NC_002655.2 hypothetical protein 756640 ybeL 957694 ybeL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286369.1 756158 D 155864 CDS NP_286370.1 15800358 957695 complement(756710..757297) 1 NC_002655.2 hypothetical protein 757297 ybeQ 957695 ybeQ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286370.1 756710 R 155864 CDS NP_286371.1 15800359 957697 complement(757532..757693) 1 NC_002655.2 hypothetical protein 757693 957697 Z0793 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286371.1 757532 R 155864 CDS NP_286372.1 15800360 957701 757852..758559 1 NC_002655.2 hypothetical protein 758559 ybeR 957701 ybeR Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286372.1 757852 D 155864 CDS NP_286373.1 15800361 957703 758556..759983 1 NC_002655.2 enzyme of polynucleotide modification 759983 ybeS 957703 ybeS Escherichia coli O157:H7 str. EDL933 enzyme of polynucleotide modification NP_286373.1 758556 D 155864 CDS NP_286374.1 15800362 957705 complement(759993..760547) 1 NC_002655.2 hypothetical protein 760547 ybeT 957705 ybeT Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286374.1 759993 R 155864 CDS NP_286375.1 15800363 957706 760649..761356 1 NC_002655.2 tRNA ligase 761356 ybeU 957706 ybeU Escherichia coli O157:H7 str. EDL933 tRNA ligase NP_286375.1 760649 D 155864 CDS NP_286376.1 15800364 957707 complement(762864..764534) 1 NC_002655.2 molecular chaperone DnaK 764534 ybeW 957707 ybeW Escherichia coli O157:H7 str. EDL933 molecular chaperone DnaK NP_286376.1 762864 R 155864 CDS NP_286377.1 15800365 957708 complement(764618..765553) 1 NC_002655.2 Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific; ribonucleoside hydrolase 1 765553 rihA 957708 rihA Escherichia coli O157:H7 str. EDL933 ribonucleoside hydrolase 1 NP_286377.1 764618 R 155864 CDS NP_286378.1 15800366 957712 complement(765671..766396) 1 NC_002655.2 glutamate/aspartate ABC transporter ATP-binding protein 766396 gltL 957712 gltL Escherichia coli O157:H7 str. EDL933 glutamate/aspartate ABC transporter ATP-binding protein NP_286378.1 765671 R 155864 CDS NP_286379.1 15800367 957713 complement(766396..767070) 1 NC_002655.2 glutamate/aspartate transport system permease 767070 gltK 957713 gltK Escherichia coli O157:H7 str. EDL933 glutamate/aspartate transport system permease NP_286379.1 766396 R 155864 CDS NP_286380.1 15800368 957714 complement(767070..767810) 1 NC_002655.2 glutamate/aspartate transport system permease 767810 gltJ 957714 gltJ Escherichia coli O157:H7 str. EDL933 glutamate/aspartate transport system permease NP_286380.1 767070 R 155864 CDS NP_286381.1 15800369 957715 complement(767980..768888) 1 NC_002655.2 glutamate and aspartate transporter subunit 768888 ybeJ 957715 ybeJ Escherichia coli O157:H7 str. EDL933 glutamate and aspartate transporter subunit NP_286381.1 767980 R 155864 CDS NP_286382.1 15800370 957716 complement(769285..770823) 1 NC_002655.2 Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase 770823 lnt 957716 lnt Escherichia coli O157:H7 str. EDL933 apolipoprotein N-acyltransferase NP_286382.1 769285 R 155864 CDS NP_286383.1 15800371 957717 complement(770848..771726) 1 NC_002655.2 transporter 771726 ybeX 957717 ybeX Escherichia coli O157:H7 str. EDL933 transporter NP_286383.1 770848 R 155864 CDS NP_286384.1 15800372 957719 complement(771816..772283) 1 NC_002655.2 metalloprotease 772283 ybeY 957719 ybeY Escherichia coli O157:H7 str. EDL933 metalloprotease NP_286384.1 771816 R 155864 CDS NP_286385.1 15800373 957720 complement(772280..773359) 1 NC_002655.2 ATP-binding protein in pho regulon 773359 ybeZ 957720 ybeZ Escherichia coli O157:H7 str. EDL933 ATP-binding protein in pho regulon NP_286385.1 772280 R 155864 CDS NP_286386.1 15800374 957722 complement(773473..774897) 1 NC_002655.2 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 774897 yleA 957722 yleA Escherichia coli O157:H7 str. EDL933 (dimethylallyl)adenosine tRNA methylthiotransferase NP_286386.1 773473 R 155864 CDS NP_286387.1 15800375 957724 775043..776218 1 NC_002655.2 catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 776218 ubiF 957724 ubiF Escherichia coli O157:H7 str. EDL933 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase NP_286387.1 775043 D 155864 CDS NP_286388.1 15800376 957740 complement(777457..779121) 1 NC_002655.2 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP; asparagine synthetase B 779121 asnB 957740 asnB Escherichia coli O157:H7 str. EDL933 asparagine synthetase B NP_286388.1 777457 R 155864 CDS NP_286389.1 15800377 957741 complement(779378..780130) 1 NC_002655.2 UMP phosphatase 780130 nagD 957741 nagD Escherichia coli O157:H7 str. EDL933 UMP phosphatase NP_286389.1 779378 R 155864 CDS NP_286390.1 15800378 957745 complement(780178..781398) 1 NC_002655.2 transcriptional repressor of nag (N-acetylglucosamine) operon 781398 nagC 957745 nagC Escherichia coli O157:H7 str. EDL933 transcriptional repressor of nag (N-acetylglucosamine) operon NP_286390.1 780178 R 155864 CDS NP_286391.1 15800379 957746 complement(781407..782555) 1 NC_002655.2 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase 782555 nagA 957746 nagA Escherichia coli O157:H7 str. EDL933 N-acetylglucosamine-6-phosphate deacetylase NP_286391.1 781407 R 155864 CDS NP_286392.1 15800380 957748 complement(782615..783415) 1 NC_002655.2 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase 783415 nagB 957748 nagB Escherichia coli O157:H7 str. EDL933 glucosamine-6-phosphate deaminase NP_286392.1 782615 R 155864 CDS NP_286393.1 15800381 957751 783748..785694 1 NC_002655.2 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system N-acetyl glucosamine specific transporter subunit IIABC 785694 nagE 957751 nagE Escherichia coli O157:H7 str. EDL933 PTS system N-acetyl glucosamine specific transporter subunit IIABC NP_286393.1 783748 D 155864 CDS NP_286394.1 15800382 957752 785897..787561 1 NC_002655.2 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 787561 glnS 957752 glnS Escherichia coli O157:H7 str. EDL933 glutaminyl-tRNA synthetase NP_286394.1 785897 D 155864 CDS NP_286395.1 15800383 957754 788140..788619 1 NC_002655.2 hypothetical protein 788619 957754 Z0828 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286395.1 788140 D 155864 CDS NP_286396.1 15800384 957756 788574..789545 1 NC_002655.2 hypothetical protein 789545 ybfM 957756 ybfM Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286396.1 788574 D 155864 CDS NP_286397.1 15800385 957757 789595..789921 1 NC_002655.2 hypothetical protein 789921 ybfN 957757 ybfN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286397.1 789595 D 155864 CDS NP_286398.1 15800386 957758 complement(790005..790451) 1 NC_002655.2 negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer; ferric uptake regulator 790451 fur 957758 fur Escherichia coli O157:H7 str. EDL933 ferric uptake regulator NP_286398.1 790005 R 155864 CDS NP_286399.1 15800387 957759 complement(790742..791272) 1 NC_002655.2 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA 791272 fldA 957759 fldA Escherichia coli O157:H7 str. EDL933 flavodoxin FldA NP_286399.1 790742 R 155864 CDS NP_286400.1 15800388 957760 complement(791412..791774) 1 NC_002655.2 LexA regulated protein 791774 ybfE 957760 ybfE Escherichia coli O157:H7 str. EDL933 LexA regulated protein NP_286400.1 791412 R 155864 CDS NP_286401.1 15800389 957763 complement(791845..792609) 1 NC_002655.2 hypothetical protein 792609 ybfF 957763 ybfF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286401.1 791845 R 155864 CDS NP_286402.1 15800390 957765 792794..793339 1 NC_002655.2 negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA 793339 seqA 957765 seqA Escherichia coli O157:H7 str. EDL933 replication initiation regulator SeqA NP_286402.1 792794 D 155864 CDS NP_286403.1 15800391 957767 793365..795005 1 NC_002655.2 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 795005 pgm 957767 pgm Escherichia coli O157:H7 str. EDL933 phosphoglucomutase NP_286403.1 793365 D 155864 CDS NP_286404.1 15800392 957769 complement(795062..796381) 1 NC_002655.2 catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system; putrescine transporter 796381 potE 957769 potE Escherichia coli O157:H7 str. EDL933 putrescine transporter NP_286404.1 795062 R 155864 CDS NP_286405.1 15800393 957771 complement(796378..798576) 1 NC_002655.2 ornithine decarboxylase 798576 speF 957771 speF Escherichia coli O157:H7 str. EDL933 ornithine decarboxylase NP_286405.1 796378 R 155864 CDS NP_286406.1 15800394 957773 799110..799244 1 NC_002655.2 No significant matches; hypothetical protein 799244 957773 Z0840 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286406.1 799110 D 155864 CDS NP_286407.1 15800395 957774 complement(799266..799943) 1 NC_002655.2 response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport; DNA-binding transcriptional activator KdpE 799943 kdpE 957774 kdpE Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional activator KdpE NP_286407.1 799266 R 155864 CDS NP_286408.1 15800396 957776 complement(799940..802624) 1 NC_002655.2 sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein; sensor protein KdpD 802624 kdpD 957776 kdpD Escherichia coli O157:H7 str. EDL933 sensor protein KdpD NP_286408.1 799940 R 155864 CDS NP_286409.1 15800397 957777 complement(802617..803189) 1 NC_002655.2 One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C 803189 kdpC 957777 kdpC Escherichia coli O157:H7 str. EDL933 potassium-transporting ATPase subunit C NP_286409.1 802617 R 155864 CDS NP_286410.1 15800398 957779 complement(803198..805246) 1 NC_002655.2 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B 805246 kdpB 957779 kdpB Escherichia coli O157:H7 str. EDL933 potassium-transporting ATPase subunit B NP_286410.1 803198 R 155864 CDS NP_286411.1 15800399 957781 complement(805269..806942) 1 NC_002655.2 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 806942 kdpA 957781 kdpA Escherichia coli O157:H7 str. EDL933 potassium-transporting ATPase subunit A NP_286411.1 805269 R 155864 CDS NP_286412.1 15800400 957782 807344..807550 1 NC_002655.2 hypothetical protein 807550 ybfA 957782 ybfA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286412.1 807344 D 155864 CDS NP_286413.1 15800401 957783 807792..811985 1 NC_002655.2 rhsC protein in rhs element, interrupted 811985 rhsC 957783 rhsC Escherichia coli O157:H7 str. EDL933 rhsC protein in rhs element, interrupted NP_286413.1 807792 D 155864 CDS NP_286415.1 15800403 957785 811985..812311 1 NC_002655.2 hypothetical protein 812311 ybfB 957785 ybfB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286415.1 811985 D 155864 CDS NP_286416.1 15800404 957786 812675..813862 1 NC_002655.2 hypothetical protein 813862 957786 Z0851 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286416.1 812675 D 155864 CDS NP_286417.1 15800405 957787 813887..814429 1 NC_002655.2 hypothetical protein 814429 ybfC 957787 ybfC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286417.1 813887 D 155864 CDS NP_286418.1 15800406 957788 815446..815535 1 NC_002655.2 No significant matches; hypothetical protein 815535 957788 Z0855 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286418.1 815446 D 155864 CDS NP_286420.1 15800408 957795 816079..817152 1 NC_002655.2 receptor 817152 957795 Z0857 Escherichia coli O157:H7 str. EDL933 receptor NP_286420.1 816079 D 155864 CDS NP_286422.1 15800410 957797 817301..817810 1 NC_002655.2 hypothetical protein 817810 ybgA 957797 ybgA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286422.1 817301 D 155864 CDS NP_286423.1 15800411 957799 817807..819225 1 NC_002655.2 UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent; deoxyribodipyrimidine photolyase 819225 phrB 957799 phrB Escherichia coli O157:H7 str. EDL933 deoxyribodipyrimidine photolyase NP_286423.1 817807 D 155864 CDS NP_286424.1 15800412 957800 complement(819375..820856) 1 NC_002655.2 transporter 820856 ybgH 957800 ybgH Escherichia coli O157:H7 str. EDL933 transporter NP_286424.1 819375 R 155864 CDS NP_286425.1 15800413 957801 821127..821870 1 NC_002655.2 hydrolase-oxidase 821870 ybgI 957801 ybgI Escherichia coli O157:H7 str. EDL933 hydrolase-oxidase NP_286425.1 821127 D 155864 CDS NP_286426.1 15800414 957802 821893..822549 1 NC_002655.2 carboxylase 822549 ybgJ 957802 ybgJ Escherichia coli O157:H7 str. EDL933 carboxylase NP_286426.1 821893 D 155864 CDS NP_286427.1 15800415 957804 822543..823475 1 NC_002655.2 carboxylase 823475 ybgK 957804 ybgK Escherichia coli O157:H7 str. EDL933 carboxylase NP_286427.1 822543 D 155864 CDS NP_286428.1 15800416 957805 823465..824199 1 NC_002655.2 LamB/YcsF family protein 824199 ybgL 957805 ybgL Escherichia coli O157:H7 str. EDL933 LamB/YcsF family protein NP_286428.1 823465 D 155864 CDS NP_286429.1 15800417 957808 824235..825026 1 NC_002655.2 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity; endonuclease VIII 825026 nei 957808 nei Escherichia coli O157:H7 str. EDL933 endonuclease VIII NP_286429.1 824235 D 155864 CDS NP_286430.1 15800418 957811 complement(825023..826114) 1 NC_002655.2 transporter 826114 abrB 957811 abrB Escherichia coli O157:H7 str. EDL933 transporter NP_286430.1 825023 R 155864 CDS NP_286431.1 15800419 957812 complement(826218..827279) 1 NC_002655.2 hypothetical protein 827279 ybgO 957812 ybgO Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286431.1 826218 R 155864 CDS NP_286432.1 15800420 957813 complement(827276..828007) 1 NC_002655.2 chaperone 828007 ybgP 957813 ybgP Escherichia coli O157:H7 str. EDL933 chaperone NP_286432.1 827276 R 155864 CDS NP_286433.1 15800421 957816 complement(828022..828171) 1 NC_002655.2 hypothetical protein 828171 957816 Z0870 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286433.1 828022 R 155864 CDS NP_286434.1 15800422 957819 complement(828310..830472) 1 NC_002655.2 outer membrane usher protein 830472 ybgQ 957819 ybgQ Escherichia coli O157:H7 str. EDL933 outer membrane usher protein NP_286434.1 828310 R 155864 CDS NP_286435.1 15800423 957821 complement(830531..831097) 1 NC_002655.2 fimbriae structural protein 831097 ybgD 957821 ybgD Escherichia coli O157:H7 str. EDL933 fimbriae structural protein NP_286435.1 830531 R 155864 CDS NP_286436.1 15800424 957824 complement(831484..832767) 1 NC_002655.2 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 832767 gltA 957824 gltA Escherichia coli O157:H7 str. EDL933 type II citrate synthase NP_286436.1 831484 R 155864 CDS NP_286437.1 15800425 957825 833476..833865 1 NC_002655.2 succinate dehydrogenase cytochrome b556 large membrane subunit 833865 sdhC 957825 sdhC Escherichia coli O157:H7 str. EDL933 succinate dehydrogenase cytochrome b556 large membrane subunit NP_286437.1 833476 D 155864 CDS NP_286438.1 15800426 957828 833859..834206 1 NC_002655.2 succinate dehydrogenase cytochrome b556 small membrane subunit 834206 sdhD 957828 sdhD Escherichia coli O157:H7 str. EDL933 succinate dehydrogenase cytochrome b556 small membrane subunit NP_286438.1 833859 D 155864 CDS NP_286439.1 15800427 957829 834206..835972 1 NC_002655.2 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 835972 sdhA 957829 sdhA Escherichia coli O157:H7 str. EDL933 succinate dehydrogenase flavoprotein subunit NP_286439.1 834206 D 155864 CDS NP_286440.1 15800428 957830 835988..836704 1 NC_002655.2 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 836704 sdhB 957830 sdhB Escherichia coli O157:H7 str. EDL933 succinate dehydrogenase iron-sulfur subunit NP_286440.1 835988 D 155864 CDS NP_286441.1 15800429 957831 836763..837023 1 NC_002655.2 hypothetical protein 837023 957831 Z0879 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286441.1 836763 D 155864 CDS NP_286442.1 15800430 957833 837005..839806 1 NC_002655.2 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 839806 sucA 957833 sucA Escherichia coli O157:H7 str. EDL933 2-oxoglutarate dehydrogenase E1 NP_286442.1 837005 D 155864 CDS NP_286443.1 15800431 957834 839821..841038 1 NC_002655.2 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 841038 sucB 957834 sucB Escherichia coli O157:H7 str. EDL933 dihydrolipoamide succinyltransferase NP_286443.1 839821 D 155864 CDS NP_286444.1 15800432 957835 841132..842298 1 NC_002655.2 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 842298 sucC 957835 sucC Escherichia coli O157:H7 str. EDL933 succinyl-CoA synthetase subunit beta NP_286444.1 841132 D 155864 CDS NP_286445.1 15800433 957836 842298..843167 1 NC_002655.2 Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 843167 sucD 957836 sucD Escherichia coli O157:H7 str. EDL933 succinyl-CoA synthetase subunit alpha NP_286445.1 842298 D 155864 CDS NP_286446.1 15800434 957838 843450..843563 1 NC_002655.2 No significant matches; hypothetical protein 843563 957838 Z0884 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286446.1 843450 D 155864 CDS NP_286447.1 15800435 957839 843834..844739 1 NC_002655.2 LysR family transcriptional regulator 844739 957839 Z0885 Escherichia coli O157:H7 str. EDL933 LysR family transcriptional regulator NP_286447.1 843834 D 155864 CDS NP_286448.1 15800436 957842 complement(844773..845375) 1 NC_002655.2 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase 845375 957842 Z0886 Escherichia coli O157:H7 str. EDL933 cob(I)yrinic acid a,c-diamide adenosyltransferase NP_286448.1 844773 R 155864 CDS NP_286449.1 15800437 957844 complement(845385..847037) 1 NC_002655.2 fumarate hydratase 847037 957844 Z0887 Escherichia coli O157:H7 str. EDL933 fumarate hydratase NP_286449.1 845385 R 155864 CDS NP_286450.1 15800438 957845 complement(847145..848425) 1 NC_002655.2 symport protein 848425 957845 Z0888 Escherichia coli O157:H7 str. EDL933 symport protein NP_286450.1 847145 R 155864 CDS NP_286451.1 15800439 957847 complement(848586..848903) 1 NC_002655.2 No significant matches; hypothetical protein 848903 957847 Z0890 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286451.1 848586 R 155864 CDS NP_286452.1 15800440 957849 complement(848900..850270) 1 NC_002655.2 hypothetical protein 850270 957849 Z0891 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286452.1 848900 R 155864 CDS NP_286453.1 15800441 957850 complement(850274..851515) 1 NC_002655.2 methylaspartate ammonia-lyase 851515 957850 Z0892 Escherichia coli O157:H7 str. EDL933 methylaspartate ammonia-lyase NP_286453.1 850274 R 155864 CDS NP_286454.1 15800442 957851 complement(851515..852960) 1 NC_002655.2 glutamate mutase subumit E 852960 957851 Z0893 Escherichia coli O157:H7 str. EDL933 glutamate mutase subumit E NP_286454.1 851515 R 155864 CDS NP_286455.1 15800443 957852 complement(852979..854367) 1 NC_002655.2 hypothetical protein 854367 957852 Z0894 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286455.1 852979 R 155864 CDS NP_286456.1 15800444 957856 complement(854367..854879) 1 NC_002655.2 converts methylaspartate to L-glutamate; methylaspartate mutase subunit S 854879 957856 Z0895 Escherichia coli O157:H7 str. EDL933 methylaspartate mutase subunit S NP_286456.1 854367 R 155864 CDS NP_286457.1 15800445 957857 complement(855003..855170) 1 NC_002655.2 No significant matches; hypothetical protein 855170 957857 Z0896 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286457.1 855003 R 155864 CDS NP_286458.1 15800446 957859 complement(855364..855786) 1 NC_002655.2 No significant matches; hypothetical protein 855786 957859 Z0897 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286458.1 855364 R 155864 CDS NP_286459.1 15800447 957860 complement(855868..856812) 1 NC_002655.2 No significant matches; hypothetical protein 856812 957860 Z0898 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286459.1 855868 R 155864 CDS NP_286461.1 15800449 957863 857615..859186 1 NC_002655.2 cytochrome d terminal oxidase, polypeptide subunit I 859186 cydA 957863 cydA Escherichia coli O157:H7 str. EDL933 cytochrome d terminal oxidase, polypeptide subunit I NP_286461.1 857615 D 155864 CDS NP_286462.1 15800450 957864 859202..860341 1 NC_002655.2 cytochrome d terminal oxidase polypeptide subunit II 860341 cydB 957864 cydB Escherichia coli O157:H7 str. EDL933 cytochrome d terminal oxidase polypeptide subunit II NP_286462.1 859202 D 155864 CDS NP_286463.1 15800451 957865 860469..860762 1 NC_002655.2 hypothetical protein 860762 ybgE 957865 ybgE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286463.1 860469 D 155864 CDS NP_286464.1 15800452 957866 860912..861316 1 NC_002655.2 catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components; acyl-CoA thioester hydrolase 861316 ybgC 957866 ybgC Escherichia coli O157:H7 str. EDL933 acyl-CoA thioester hydrolase NP_286464.1 860912 D 155864 CDS NP_286465.1 15800453 957868 861313..862005 1 NC_002655.2 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolQ 862005 tolQ 957868 tolQ Escherichia coli O157:H7 str. EDL933 colicin uptake protein TolQ NP_286465.1 861313 D 155864 CDS NP_286466.1 15800454 957870 862009..862437 1 NC_002655.2 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 862437 tolR 957870 tolR Escherichia coli O157:H7 str. EDL933 colicin uptake protein TolR NP_286466.1 862009 D 155864 CDS NP_286467.1 15800455 957872 862502..863686 1 NC_002655.2 inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins; cell envelope integrity inner membrane protein TolA 863686 tolA 957872 tolA Escherichia coli O157:H7 str. EDL933 cell envelope integrity inner membrane protein TolA NP_286467.1 862502 D 155864 CDS NP_286468.1 15800456 957873 863819..865111 1 NC_002655.2 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 865111 tolB 957873 tolB Escherichia coli O157:H7 str. EDL933 translocation protein TolB NP_286468.1 863819 D 155864 CDS NP_286469.1 15800457 957874 865146..865667 1 NC_002655.2 peptidoglycan-associated outer membrane lipoprotein 865667 pal 957874 pal Escherichia coli O157:H7 str. EDL933 peptidoglycan-associated outer membrane lipoprotein NP_286469.1 865146 D 155864 CDS NP_286470.1 15800458 957876 865677..866468 1 NC_002655.2 periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity; tol-pal system protein YbgF 866468 ybgF 957876 ybgF Escherichia coli O157:H7 str. EDL933 tol-pal system protein YbgF NP_286470.1 865677 D 155864 CDS NP_286471.1 15800459 957889 867603..868646 1 NC_002655.2 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 868646 nadA 957889 nadA Escherichia coli O157:H7 str. EDL933 quinolinate synthetase NP_286471.1 867603 D 155864 CDS NP_286472.1 15800460 957890 868684..869403 1 NC_002655.2 required for NMN transport 869403 pnuC 957890 pnuC Escherichia coli O157:H7 str. EDL933 required for NMN transport NP_286472.1 868684 D 155864 CDS NP_286473.1 15800461 957891 complement(869400..870335) 1 NC_002655.2 involved in zinc efflux across the cytoplasmic membrane; zinc transporter ZitB 870335 ybgR 957891 ybgR Escherichia coli O157:H7 str. EDL933 zinc transporter ZitB NP_286473.1 869400 R 155864 CDS NP_286474.1 15800462 957892 complement(870449..870829) 1 NC_002655.2 homeobox protein 870829 957892 Z0923 Escherichia coli O157:H7 str. EDL933 homeobox protein NP_286474.1 870449 R 155864 CDS NP_286475.1 15800463 957894 871145..872197 1 NC_002655.2 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 872197 aroG 957894 aroG Escherichia coli O157:H7 str. EDL933 phospho-2-dehydro-3-deoxyheptonate aldolase NP_286475.1 871145 D 155864 CDS NP_286476.1 15800464 957895 complement(872363..873115) 1 NC_002655.2 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 873115 gpmA 957895 gpmA Escherichia coli O157:H7 str. EDL933 phosphoglyceromutase NP_286476.1 872363 R 155864 CDS NP_286477.1 15800465 957897 complement(873317..874357) 1 NC_002655.2 catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose; aldose 1-epimerase 874357 galM 957897 galM Escherichia coli O157:H7 str. EDL933 aldose 1-epimerase NP_286477.1 873317 R 155864 CDS NP_286478.1 15800466 957898 complement(874351..875499) 1 NC_002655.2 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 875499 galK 957898 galK Escherichia coli O157:H7 str. EDL933 galactokinase NP_286478.1 874351 R 155864 CDS NP_286479.1 15800467 957899 complement(875503..876549) 1 NC_002655.2 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase 876549 galT 957899 galT Escherichia coli O157:H7 str. EDL933 galactose-1-phosphate uridylyltransferase NP_286479.1 875503 R 155864 CDS NP_286480.1 15800468 957904 complement(876559..877575) 1 NC_002655.2 UDP-galactose-4-epimerase 877575 galE 957904 galE Escherichia coli O157:H7 str. EDL933 UDP-galactose-4-epimerase NP_286480.1 876559 R 155864 CDS NP_286481.2 161367632 957906 complement(877837..879309) 1 NC_002655.2 contains 2 ATP-binding cassettes; involved in the transport of molybdenum; molybdenum transport ATP-binding protein ModF 879309 modF 957906 modF Escherichia coli O157:H7 str. EDL933 molybdenum transport ATP-binding protein ModF NP_286481.2 877837 R 155864 CDS NP_286482.1 15800470 957908 complement(879377..880165) 1 NC_002655.2 represses the modABCD operon and activates the moaABCD and napFDAGHBC operons; DNA-binding transcriptional regulator ModE 880165 modE 957908 modE Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator ModE NP_286482.1 879377 R 155864 CDS NP_286483.1 15800471 957909 880294..880443 1 NC_002655.2 hypothetical protein 880443 957909 Z0932 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286483.1 880294 D 155864 CDS NP_286484.1 15800472 957910 880610..881383 1 NC_002655.2 with ModCB is involved in the high-affinity transport of molybdate; molybdate transporter periplasmic protein 881383 modA 957910 modA Escherichia coli O157:H7 str. EDL933 molybdate transporter periplasmic protein NP_286484.1 880610 D 155864 CDS NP_286485.1 15800473 957911 881383..882072 1 NC_002655.2 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease 882072 modB 957911 modB Escherichia coli O157:H7 str. EDL933 molybdate ABC transporter permease NP_286485.1 881383 D 155864 CDS NP_286486.1 15800474 957912 882075..883133 1 NC_002655.2 Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein 883133 modC 957912 modC Escherichia coli O157:H7 str. EDL933 molybdate transporter ATP-binding protein NP_286486.1 882075 D 155864 CDS NP_286487.1 15800475 957914 complement(883134..883952) 1 NC_002655.2 YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily; phosphotransferase 883952 ybhA 957914 ybhA Escherichia coli O157:H7 str. EDL933 phosphotransferase NP_286487.1 883134 R 155864 CDS NP_286488.1 15800476 957915 884107..885102 1 NC_002655.2 catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate; 6-phosphogluconolactonase 885102 ybhE 957915 ybhE Escherichia coli O157:H7 str. EDL933 6-phosphogluconolactonase NP_286488.1 884107 D 155864 CDS NP_286489.1 15800477 957916 complement(885143..886159) 1 NC_002655.2 LysR family transcriptional regulator 886159 ybhD 957916 ybhD Escherichia coli O157:H7 str. EDL933 LysR family transcriptional regulator NP_286489.1 885143 R 155864 CDS NP_286490.1 15800478 957919 886280..887332 1 NC_002655.2 hypothetical protein 887332 ybhH 957919 ybhH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286490.1 886280 D 155864 CDS NP_286491.1 15800479 957920 887409..888842 1 NC_002655.2 membrane pump protein 888842 ybhI 957920 ybhI Escherichia coli O157:H7 str. EDL933 membrane pump protein NP_286491.1 887409 D 155864 CDS NP_286492.2 161367631 957921 889025..891286 1 NC_002655.2 hypothetical protein 891286 ybhJ 957921 ybhJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286492.2 889025 D 155864 CDS NP_286493.1 15800481 957922 complement(891427..892710) 1 NC_002655.2 outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase; pectinesterase 892710 ybhC 957922 ybhC Escherichia coli O157:H7 str. EDL933 pectinesterase NP_286493.1 891427 R 155864 CDS NP_286494.1 15800482 957923 complement(892845..893708) 1 NC_002655.2 integrase encoded by prophage CP-933K; partial 893708 957923 Z0946 Escherichia coli O157:H7 str. EDL933 integrase encoded by prophage CP-933K; partial NP_286494.1 892845 R 155864 CDS NP_286495.1 15800483 957926 complement(894148..894315) 1 NC_002655.2 hypothetical protein 894315 957926 Z0947 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286495.1 894148 R 155864 CDS NP_286496.1 15800484 957927 894558..895160 1 NC_002655.2 No significant matches; hypothetical protein 895160 957927 Z0948 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286496.1 894558 D 155864 CDS NP_286497.1 15800485 957929 complement(895691..895906) 1 NC_002655.2 hypothetical protein 895906 957929 Z0949 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286497.1 895691 R 155864 CDS NP_286498.1 15800486 957931 complement(895983..896174) 1 NC_002655.2 hypothetical protein 896174 957931 Z0950 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286498.1 895983 R 155864 CDS NP_286499.1 15800487 957932 complement(896326..897006) 1 NC_002655.2 exonuclease 897006 957932 Z0951 Escherichia coli O157:H7 str. EDL933 exonuclease NP_286499.1 896326 R 155864 CDS NP_286500.1 15800488 957933 complement(897003..897650) 1 NC_002655.2 Bet recombination protein of prophage CP-933K 897650 957933 Z0952 Escherichia coli O157:H7 str. EDL933 Bet recombination protein of prophage CP-933K NP_286500.1 897003 R 155864 CDS NP_286501.1 15800489 957934 898043..898666 1 NC_002655.2 hypothetical protein 898666 957934 Z0953 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286501.1 898043 D 155864 CDS NP_286502.1 15800490 957935 898894..899325 1 NC_002655.2 hypothetical protein 899325 957935 Z0954 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286502.1 898894 D 155864 CDS NP_286503.1 15800491 957936 complement(899537..900496) 1 NC_002655.2 hypothetical protein 900496 957936 Z0955 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286503.1 899537 R 155864 CDS NP_286504.1 15800492 957937 900887..901660 1 NC_002655.2 antiterminator Q protein of prophage CP-933K 901660 957937 Z0956 Escherichia coli O157:H7 str. EDL933 antiterminator Q protein of prophage CP-933K NP_286504.1 900887 D 155864 CDS NP_286505.1 15800493 957938 901830..902588 1 NC_002655.2 hypothetical protein 902588 957938 Z0957 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286505.1 901830 D 155864 CDS NP_286506.1 15800494 957940 902731..902832 1 NC_002655.2 No significant matches; hypothetical protein 902832 957940 Z0958 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286506.1 902731 D 155864 CDS NP_286508.1 15800496 957943 903669..904166 1 NC_002655.2 lysozyme protein R of prophage CP-933K 904166 957943 Z0960 Escherichia coli O157:H7 str. EDL933 lysozyme protein R of prophage CP-933K NP_286508.1 903669 D 155864 CDS NP_286509.1 15800497 957945 904163..904630 1 NC_002655.2 endopeptidase Rz of prophage CP-933K 904630 957945 Z0961 Escherichia coli O157:H7 str. EDL933 endopeptidase Rz of prophage CP-933K NP_286509.1 904163 D 155864 CDS NP_286510.1 15800498 957947 complement(905200..905295) 1 NC_002655.2 No significant matches; hypothetical protein 905295 957947 Z0962 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286510.1 905200 R 155864 CDS NP_286511.1 15800499 957948 905445..905936 1 NC_002655.2 No significant matches; hypothetical protein 905936 957948 Z0963 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286511.1 905445 D 155864 CDS NP_286512.1 15800500 957949 905936..908038 1 NC_002655.2 DNA packaging protein of prophage CP-933K 908038 957949 Z0964 Escherichia coli O157:H7 str. EDL933 DNA packaging protein of prophage CP-933K NP_286512.1 905936 D 155864 CDS NP_286513.1 15800501 957950 908175..909299 1 NC_002655.2 hypothetical protein 909299 957950 Z0965 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286513.1 908175 D 155864 CDS NP_286514.1 15800502 957952 909394..909756 1 NC_002655.2 No significant matches; hypothetical protein 909756 957952 Z0966 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286514.1 909394 D 155864 CDS NP_286515.1 15800503 957953 909701..911728 1 NC_002655.2 protease encoded in prophage CP-933K 911728 957953 Z0967 Escherichia coli O157:H7 str. EDL933 protease encoded in prophage CP-933K NP_286515.1 909701 D 155864 CDS NP_286516.1 15800504 957955 911815..912138 1 NC_002655.2 No significant matches; hypothetical protein 912138 957955 Z0968 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286516.1 911815 D 155864 CDS NP_286517.1 15800505 957956 912131..912406 1 NC_002655.2 No significant matches; hypothetical protein 912406 957956 Z0969 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286517.1 912131 D 155864 CDS NP_286518.1 15800506 957958 912418..912996 1 NC_002655.2 tail component of prophage CP-933K 912996 957958 Z0970 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933K NP_286518.1 912418 D 155864 CDS NP_286519.1 15800507 957959 912993..913394 1 NC_002655.2 tail component of prophage CP-933K 913394 957959 Z0971 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933K NP_286519.1 912993 D 155864 CDS NP_286520.1 15800508 957961 913399..914148 1 NC_002655.2 tail component of prophage CP-933K 914148 957961 Z0972 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933K NP_286520.1 913399 D 155864 CDS NP_286521.1 15800509 957962 914197..914595 1 NC_002655.2 tail component of prophage CP-933K 914595 957962 Z0973 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933K NP_286521.1 914197 D 155864 CDS NP_286522.1 15800510 957963 914616..914933 1 NC_002655.2 tail component of prophage CP-933K 914933 957963 Z0974 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933K NP_286522.1 914616 D 155864 CDS NP_286523.1 15800511 957964 914905..917970 1 NC_002655.2 tail component of prophage CP-933K 917970 957964 Z0975 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933K NP_286523.1 914905 D 155864 CDS NP_286524.1 15800512 957966 917970..918299 1 NC_002655.2 tail component of prophage CP-933K 918299 957966 Z0976 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933K NP_286524.1 917970 D 155864 CDS NP_286525.1 15800513 957969 918309..919007 1 NC_002655.2 tail component of prophage CP-933K 919007 957969 Z0977 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933K NP_286525.1 918309 D 155864 CDS NP_286526.1 15800514 957970 919082..919756 1 NC_002655.2 tail component of prophage CP-933K 919756 957970 Z0978 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933K NP_286526.1 919082 D 155864 CDS NP_286527.1 15800515 957973 919654..920301 1 NC_002655.2 tail component of prophage CP-933K 920301 957973 Z0979 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933K NP_286527.1 919654 D 155864 CDS NP_286528.1 15800516 957974 920362..923778 1 NC_002655.2 tail component of prophage CP-933K 923778 957974 Z0980 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933K NP_286528.1 920362 D 155864 CDS NP_286529.1 15800517 957976 923849..924448 1 NC_002655.2 prophage protein 924448 lomK 957976 lomK Escherichia coli O157:H7 str. EDL933 prophage protein NP_286529.1 923849 D 155864 CDS NP_286530.1 15800518 957977 924502..925824 1 NC_002655.2 tail component of prophage CP-933K 925824 957977 Z0982 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933K NP_286530.1 924502 D 155864 CDS NP_286531.1 15800519 957980 925787..926095 1 NC_002655.2 hypothetical protein 926095 957980 Z0984 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286531.1 925787 D 155864 CDS NP_286532.1 15800520 957982 926272..927252 1 NC_002655.2 hypothetical protein 927252 957982 Z0985 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286532.1 926272 D 155864 CDS NP_286533.1 15800521 957984 927313..928305 1 NC_002655.2 No significant matches; hypothetical protein 928305 957984 Z0986 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286533.1 927313 D 155864 CDS NP_286534.1 15800522 957985 929133..930014 1 NC_002655.2 No significant matches; hypothetical protein 930014 957985 Z0989 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286534.1 929133 D 155864 CDS NP_286535.1 15800523 957986 930245..930943 1 NC_002655.2 No significant matches; hypothetical protein 930943 957986 Z0990 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286535.1 930245 D 155864 CDS NP_286536.1 15800524 957989 complement(931451..931927) 1 NC_002655.2 YbhB; similar to rat and human kinase inhibitory proteins; kinase inhibitor protein 931927 ybhB 957989 ybhB Escherichia coli O157:H7 str. EDL933 kinase inhibitor protein NP_286536.1 931451 R 155864 CDS NP_286537.1 15800525 957991 complement(931986..933275) 1 NC_002655.2 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 933275 bioA 957991 bioA Escherichia coli O157:H7 str. EDL933 adenosylmethionine-8-amino-7-oxononanoate aminotransferase NP_286537.1 931986 R 155864 CDS NP_286538.1 15800526 957992 933362..934402 1 NC_002655.2 biotin synthase 934402 bioB 957992 bioB Escherichia coli O157:H7 str. EDL933 biotin synthase NP_286538.1 933362 D 155864 CDS NP_286539.1 15800527 957994 934399..935553 1 NC_002655.2 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 935553 bioF 957994 bioF Escherichia coli O157:H7 str. EDL933 8-amino-7-oxononanoate synthase NP_286539.1 934399 D 155864 CDS NP_286540.1 15800528 957995 935540..936295 1 NC_002655.2 methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth; biotin biosynthesis protein BioC 936295 bioC 957995 bioC Escherichia coli O157:H7 str. EDL933 biotin biosynthesis protein BioC NP_286540.1 935540 D 155864 CDS NP_286541.1 15800529 957997 936288..936965 1 NC_002655.2 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 936965 bioD 957997 bioD Escherichia coli O157:H7 str. EDL933 dithiobiotin synthetase NP_286541.1 936288 D 155864 CDS NP_286542.1 15800530 957998 937545..939566 1 NC_002655.2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 939566 uvrB 957998 uvrB Escherichia coli O157:H7 str. EDL933 excinuclease ABC subunit B NP_286542.1 937545 D 155864 CDS NP_286543.1 15800531 957999 complement(939757..940665) 1 NC_002655.2 structural protein 940665 ybhK 957999 ybhK Escherichia coli O157:H7 str. EDL933 structural protein NP_286543.1 939757 R 155864 CDS NP_286544.1 15800532 958000 941062..942051 1 NC_002655.2 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 942051 moaA 958000 moaA Escherichia coli O157:H7 str. EDL933 molybdenum cofactor biosynthesis protein A NP_286544.1 941062 D 155864 CDS NP_286545.1 15800533 958001 942073..942585 1 NC_002655.2 molybdopterin biosynthesis, protein B 942585 moaB 958001 moaB Escherichia coli O157:H7 str. EDL933 molybdopterin biosynthesis, protein B NP_286545.1 942073 D 155864 CDS NP_286546.1 15800534 958003 942588..943073 1 NC_002655.2 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 943073 moaC 958003 moaC Escherichia coli O157:H7 str. EDL933 molybdenum cofactor biosynthesis protein MoaC NP_286546.1 942588 D 155864 CDS NP_286547.1 15800535 958004 943066..943311 1 NC_002655.2 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit 943311 moaD 958004 moaD Escherichia coli O157:H7 str. EDL933 molybdopterin synthase small subunit NP_286547.1 943066 D 155864 CDS NP_286548.1 15800536 958005 943313..943765 1 NC_002655.2 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin guanine dinucleotide biosynthesis protein MoaE 943765 moaE 958005 moaE Escherichia coli O157:H7 str. EDL933 molybdopterin guanine dinucleotide biosynthesis protein MoaE NP_286548.1 943313 D 155864 CDS NP_286549.1 15800537 958007 943901..944605 1 NC_002655.2 hypothetical protein 944605 ybhL 958007 ybhL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286549.1 943901 D 155864 CDS NP_286550.1 15800538 958010 944813..945526 1 NC_002655.2 hypothetical protein 945526 ybhM 958010 ybhM Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286550.1 944813 D 155864 CDS NP_286551.1 15800539 958011 complement(945562..946518) 1 NC_002655.2 hypothetical protein 946518 ybhN 958011 ybhN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286551.1 945562 R 155864 CDS NP_286552.1 15800540 958012 complement(946518..947759) 1 NC_002655.2 cardiolipin synthase 2 947759 ybhO 958012 ybhO Escherichia coli O157:H7 str. EDL933 cardiolipin synthase 2 NP_286552.1 946518 R 155864 CDS NP_286553.1 15800541 958013 complement(947756..948517) 1 NC_002655.2 hypothetical protein 948517 ybhP 958013 ybhP Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286553.1 947756 R 155864 CDS NP_286554.1 15800542 958014 948650..949060 1 NC_002655.2 hypothetical protein 949060 ybhQ 958014 ybhQ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286554.1 948650 D 155864 CDS NP_286555.1 15800543 958016 complement(949022..950128) 1 NC_002655.2 hypothetical protein 950128 ybhR 958016 ybhR Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286555.1 949022 R 155864 CDS NP_286556.1 15800544 958017 complement(950139..951272) 1 NC_002655.2 hypothetical protein 951272 ybhS 958017 ybhS Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286556.1 950139 R 155864 CDS NP_286557.1 15800545 958020 complement(951265..953016) 1 NC_002655.2 ABC transporter ATP-binding protein 953016 ybhF 958020 ybhF Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_286557.1 951265 R 155864 CDS NP_286558.1 15800546 958021 complement(952994..953992) 1 NC_002655.2 hypothetical protein 953992 958021 Z1015 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286558.1 952994 R 155864 CDS NP_286559.1 15800547 958023 complement(953992..954675) 1 NC_002655.2 DNA-binding transcriptional regulator 954675 ybiH 958023 ybiH Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator NP_286559.1 953992 R 155864 CDS NP_286560.1 15800548 958024 954892..956259 1 NC_002655.2 this helicase is not essential cell growth; ATP-dependent RNA helicase RhlE 956259 rhlE 958024 rhlE Escherichia coli O157:H7 str. EDL933 ATP-dependent RNA helicase RhlE NP_286560.1 954892 D 155864 CDS NP_286561.1 15800549 958025 956323..956421 1 NC_002655.2 No significant matches; hypothetical protein 956421 958025 Z1018 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286561.1 956323 D 155864 CDS NP_286562.1 15800550 958026 956867..958879 1 NC_002655.2 hypothetical protein 958879 958026 Z1019 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286562.1 956867 D 155864 CDS NP_286563.1 15800551 958028 959163..961313 1 NC_002655.2 helicase involved in DNA repair and perhaps also replication; ATP-dependent DNA helicase DinG 961313 dinG 958028 dinG Escherichia coli O157:H7 str. EDL933 ATP-dependent DNA helicase DinG NP_286563.1 959163 D 155864 CDS NP_286564.1 15800552 958029 961341..962303 1 NC_002655.2 glycosyl transferase 962303 ybiB 958029 ybiB Escherichia coli O157:H7 str. EDL933 glycosyl transferase NP_286564.1 961341 D 155864 CDS NP_286565.1 15800553 958033 962445..963530 1 NC_002655.2 hypothetical protein 963530 ybiC 958033 ybiC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286565.1 962445 D 155864 CDS NP_286566.1 15800554 958035 complement(963760..964020) 1 NC_002655.2 hypothetical protein 964020 ybiJ 958035 ybiJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286566.1 963760 R 155864 CDS NP_286567.1 15800555 958039 complement(964285..964551) 1 NC_002655.2 hypothetical protein 964551 ybiI 958039 ybiI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286567.1 964285 R 155864 CDS NP_286568.1 15800556 958040 complement(964627..965313) 1 NC_002655.2 hydroxylase 965313 ybiX 958040 ybiX Escherichia coli O157:H7 str. EDL933 hydroxylase NP_286568.1 964627 R 155864 CDS NP_286569.1 15800557 958041 complement(965355..967637) 1 NC_002655.2 Fiu; YbiL; porin involved in the uptake of iron complexed with catecholate siderophores (e.g. dihydroxybenzoylserine, dihydroxybenzoate) and beta lactam agents; Fiu interacts with TonB which provides the energy required for transport across the outer membrane; acts as a receptor for iron-siderophores and microcins E492, M, and H47; outer membrane protein; catecholate siderophore receptor Fiu 967637 958041 Z1026 Escherichia coli O157:H7 str. EDL933 catecholate siderophore receptor Fiu NP_286569.1 965355 R 155864 CDS NP_286570.1 15800558 958042 complement(967902..968306) 1 NC_002655.2 hypothetical protein 968306 ybiM 958042 ybiM Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286570.1 967902 R 155864 CDS NP_286571.1 15800559 958047 968357..969364 1 NC_002655.2 SAM-dependent methyltransferase 969364 ybiN 958047 ybiN Escherichia coli O157:H7 str. EDL933 SAM-dependent methyltransferase NP_286571.1 968357 D 155864 CDS NP_286572.1 15800560 958048 complement(969361..971586) 1 NC_002655.2 hypothetical protein 971586 ybiO 958048 ybiO Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286572.1 969361 R 155864 CDS NP_286573.1 15800561 958052 complement(971703..972425) 1 NC_002655.2 similar to ABC transporter ATP-binding proteins; glutamine ABC transporter ATP-binding protein 972425 glnQ 958052 glnQ Escherichia coli O157:H7 str. EDL933 glutamine ABC transporter ATP-binding protein NP_286573.1 971703 R 155864 CDS NP_286574.1 15800562 958053 complement(972422..973081) 1 NC_002655.2 similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine; glutamine ABC transporter permease 973081 glnP 958053 glnP Escherichia coli O157:H7 str. EDL933 glutamine ABC transporter permease NP_286574.1 972422 R 155864 CDS NP_286575.1 15800563 958054 complement(973220..973966) 1 NC_002655.2 similar to periplasmic-binding component of ABC transporters; glutamine ABC transporter periplasmic protein 973966 glnH 958054 glnH Escherichia coli O157:H7 str. EDL933 glutamine ABC transporter periplasmic protein NP_286575.1 973220 R 155864 CDS NP_286576.1 15800564 958055 complement(974370..974873) 1 NC_002655.2 binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage; DNA starvation/stationary phase protection protein Dps 974873 dps 958055 dps Escherichia coli O157:H7 str. EDL933 DNA starvation/stationary phase protection protein Dps NP_286576.1 974370 R 155864 CDS NP_286577.1 15800565 958056 complement(975172..976059) 1 NC_002655.2 threonine and homoserine efflux system 976059 ybiF 958056 ybiF Escherichia coli O157:H7 str. EDL933 threonine and homoserine efflux system NP_286577.1 975172 R 155864 CDS NP_286578.1 15800566 958057 976412..976927 1 NC_002655.2 OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains; outer membrane protein X 976927 ompX 958057 ompX Escherichia coli O157:H7 str. EDL933 outer membrane protein X NP_286578.1 976412 D 155864 CDS NP_286579.1 15800567 958061 complement(976976..978559) 1 NC_002655.2 hypothetical protein 978559 ybiP 958061 ybiP Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286579.1 976976 R 155864 CDS NP_286580.1 15800568 958074 978795..978902 1 NC_002655.2 hypothetical protein 978902 958074 Z1038 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286580.1 978795 D 155864 CDS NP_286581.1 15800569 958082 979145..979612 1 NC_002655.2 Transcriptional regulator that represses the manganese transporter MntH when manganese is present; manganese transport regulator MntR 979612 958082 Z1039 Escherichia coli O157:H7 str. EDL933 manganese transport regulator MntR NP_286581.1 979145 D 155864 CDS NP_286582.1 15800570 958083 979609..980727 1 NC_002655.2 hypothetical protein 980727 ybiR 958083 ybiR Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286582.1 979609 D 155864 CDS NP_286583.1 15800571 958084 complement(980785..981705) 1 NC_002655.2 hypothetical protein 981705 ybiS 958084 ybiS Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286583.1 980785 R 155864 CDS NP_286584.1 15800572 958094 981925..983517 1 NC_002655.2 ABC transporter ATP-binding protein 983517 ybiT 958094 ybiT Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_286584.1 981925 D 155864 CDS NP_286585.1 15800573 958095 complement(983685..984950) 1 NC_002655.2 hypothetical protein 984950 ybiU 958095 ybiU Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286585.1 983685 R 155864 CDS NP_286586.1 15800574 958099 complement(985103..985918) 1 NC_002655.2 hypothetical protein 985918 958099 Z1044 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286586.1 985103 R 155864 CDS NP_286587.1 15804975 959651 complement(join(986064..987962,987962..988495)) 1 NC_002655.2 pyruvate-formate lyase 988495 959651 Z1046m Escherichia coli O157:H7 str. EDL933 pyruvate-formate lyase NP_286587.1 986064 R 155864 CDS NP_286588.2 157267357 958103 complement(988501..989400) 1 NC_002655.2 pyruvate formate-lyase 2 activating enzyme 989400 ybiY 958103 ybiY Escherichia coli O157:H7 str. EDL933 pyruvate formate-lyase 2 activating enzyme NP_286588.2 988501 R 155864 CDS NP_286589.2 161367630 958104 989531..990193 1 NC_002655.2 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 990193 mipB 958104 mipB Escherichia coli O157:H7 str. EDL933 fructose-6-phosphate aldolase NP_286589.2 989531 D 155864 CDS NP_286590.1 15800577 958112 complement(990372..991121) 1 NC_002655.2 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB 991121 moeB 958112 moeB Escherichia coli O157:H7 str. EDL933 molybdopterin biosynthesis protein MoeB NP_286590.1 990372 R 155864 CDS NP_286591.1 15800578 958116 complement(991121..992356) 1 NC_002655.2 is involved in the formation of active molybdenum cofactor and the chelation of molybdenum; molybdopterin biosynthesis protein MoeA 992356 moeA 958116 moeA Escherichia coli O157:H7 str. EDL933 molybdopterin biosynthesis protein MoeA NP_286591.1 991121 R 155864 CDS NP_286592.1 15804993 959650 992560..993525 1 NC_002655.2 L-asparaginase 993525 959650 Z1051m Escherichia coli O157:H7 str. EDL933 L-asparaginase NP_286592.1 992560 D 155864 CDS NP_286593.1 15800579 958119 993545..995383 1 NC_002655.2 with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains; glutathione transporter ATP-binding protein 995383 958119 Z1053 Escherichia coli O157:H7 str. EDL933 glutathione transporter ATP-binding protein NP_286593.1 993545 D 155864 CDS NP_286594.1 15800580 958120 995403..996941 1 NC_002655.2 transporter 996941 958120 Z1054 Escherichia coli O157:H7 str. EDL933 transporter NP_286594.1 995403 D 155864 CDS NP_286595.1 15800581 958122 996959..997879 1 NC_002655.2 transport system permease 997879 958122 Z1055 Escherichia coli O157:H7 str. EDL933 transport system permease NP_286595.1 996959 D 155864 CDS NP_286596.1 15800582 958128 997882..998793 1 NC_002655.2 transport system permease 998793 958128 Z1056 Escherichia coli O157:H7 str. EDL933 transport system permease NP_286596.1 997882 D 155864 CDS NP_286597.1 15800583 958133 998971..1001319 1 NC_002655.2 hypothetical protein 1001319 958133 Z1057 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286597.1 998971 D 155864 CDS NP_286598.1 15800584 958134 1001327..1002655 1 NC_002655.2 hypothetical protein 1002655 958134 Z1058 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286598.1 1001327 D 155864 CDS NP_286599.1 15800585 958141 complement(1002725..1003054) 1 NC_002655.2 hypothetical protein 1003054 958141 Z1059 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286599.1 1002725 R 155864 CDS NP_286600.1 15800586 958143 complement(1003044..1003430) 1 NC_002655.2 hypothetical protein 1003430 958143 Z1060 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286600.1 1003044 R 155864 CDS NP_286601.1 15800587 958145 complement(1003656..1004981) 1 NC_002655.2 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit; ribosomal protein S12 methylthiotransferase 1004981 rimO 958145 rimO Escherichia coli O157:H7 str. EDL933 ribosomal protein S12 methylthiotransferase NP_286601.1 1003656 R 155864 CDS NP_286602.1 15800588 958146 1005194..1005577 1 NC_002655.2 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssR 1005577 bssR 958146 bssR Escherichia coli O157:H7 str. EDL933 biofilm formation regulatory protein BssR NP_286602.1 1005194 D 155864 CDS NP_286603.1 15800589 958149 1005688..1006803 1 NC_002655.2 dehydrogenase 1006803 yliI 958149 yliI Escherichia coli O157:H7 str. EDL933 dehydrogenase NP_286603.1 1005688 D 155864 CDS NP_286604.1 15800590 958156 complement(1006800..1007432) 1 NC_002655.2 transferase 1007432 yliJ 958156 yliJ Escherichia coli O157:H7 str. EDL933 transferase NP_286604.1 1006800 R 155864 CDS NP_286605.1 15800591 958157 1007672..1008874 1 NC_002655.2 penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 1008874 dacC 958157 dacC Escherichia coli O157:H7 str. EDL933 D-alanyl-D-alanine carboxypeptidase NP_286605.1 1007672 D 155864 CDS NP_286606.1 15800592 958158 complement(1008921..1009679) 1 NC_002655.2 DeoR family transcriptional regulator 1009679 deoR 958158 deoR Escherichia coli O157:H7 str. EDL933 DeoR family transcriptional regulator NP_286606.1 1008921 R 155864 CDS NP_286607.1 15800593 958159 complement(1009737..1010333) 1 NC_002655.2 undecaprenyl pyrophosphate phosphatase 1010333 ybjG 958159 ybjG Escherichia coli O157:H7 str. EDL933 undecaprenyl pyrophosphate phosphatase NP_286607.1 1009737 R 155864 CDS NP_286608.1 15800594 958160 1010618..1011850 1 NC_002655.2 proton motive force efflux pump 1011850 cmr 958160 cmr Escherichia coli O157:H7 str. EDL933 proton motive force efflux pump NP_286608.1 1010618 D 155864 CDS NP_286609.1 15800595 958168 complement(1011891..1012175) 1 NC_002655.2 hypothetical protein 1012175 ybjH 958168 ybjH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286609.1 1011891 R 155864 CDS NP_286610.1 15800596 958173 complement(1012261..1013049) 1 NC_002655.2 hypothetical protein 1013049 958173 Z1071 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286610.1 1012261 R 155864 CDS NP_286611.1 15800597 958182 complement(1013076..1014284) 1 NC_002655.2 DEOR-type transcriptional regulator 1014284 958182 Z1072 Escherichia coli O157:H7 str. EDL933 DEOR-type transcriptional regulator NP_286611.1 1013076 R 155864 CDS NP_286612.1 15800598 958183 1014368..1014904 1 NC_002655.2 DEOR-type transcriptional regulator 1014904 958183 Z1073 Escherichia coli O157:H7 str. EDL933 DEOR-type transcriptional regulator NP_286612.1 1014368 D 155864 CDS NP_286613.1 15800599 958193 complement(1015079..1016764) 1 NC_002655.2 hypothetical protein 1016764 958193 Z1074 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286613.1 1015079 R 155864 CDS NP_286614.1 15800600 958194 1017035..1017412 1 NC_002655.2 hypothetical protein 1017412 ybjM 958194 ybjM Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286614.1 1017035 D 155864 CDS NP_286615.1 15800601 958195 complement(1017442..1017699) 1 NC_002655.2 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin 1017699 grxA 958195 grxA Escherichia coli O157:H7 str. EDL933 glutaredoxin NP_286615.1 1017442 R 155864 CDS NP_286616.1 15800602 958199 1017859..1018146 1 NC_002655.2 YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function; hypothetical protein 1018146 ybjC 958199 ybjC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286616.1 1017859 D 155864 CDS NP_286617.1 15800603 958200 1018130..1018852 1 NC_002655.2 NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds; nitroreductase A 1018852 mdaA 958200 mdaA Escherichia coli O157:H7 str. EDL933 nitroreductase A NP_286617.1 1018130 D 155864 CDS NP_286618.1 15800604 958206 1018913..1019815 1 NC_002655.2 responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6; ribosomal protein S6 modification protein 1019815 rimK 958206 rimK Escherichia coli O157:H7 str. EDL933 ribosomal protein S6 modification protein NP_286618.1 1018913 D 155864 CDS NP_286619.1 15800605 958210 1019903..1020379 1 NC_002655.2 sensory transduction regulator 1020379 ybjN 958210 ybjN Escherichia coli O157:H7 str. EDL933 sensory transduction regulator NP_286619.1 1019903 D 155864 CDS NP_286620.1 15800606 958211 1020730..1021842 1 NC_002655.2 putrescine ABC transporter periplasmic-binding protein 1021842 potF 958211 potF Escherichia coli O157:H7 str. EDL933 putrescine ABC transporter periplasmic-binding protein NP_286620.1 1020730 D 155864 CDS NP_286621.1 15800607 958215 1021937..1023070 1 NC_002655.2 part of the PotFGHI ATP-dependent putrescine transporter; putrescine ABC transporter ATP-binding protein 1023070 potG 958215 potG Escherichia coli O157:H7 str. EDL933 putrescine ABC transporter ATP-binding protein NP_286621.1 1021937 D 155864 CDS NP_286622.1 15800608 958218 1023080..1024033 1 NC_002655.2 putrescine ABC transporter membrane protein 1024033 potH 958218 potH Escherichia coli O157:H7 str. EDL933 putrescine ABC transporter membrane protein NP_286622.1 1023080 D 155864 CDS NP_286623.1 15800609 958223 1024030..1024875 1 NC_002655.2 putrescine ABC transporter membrane protein 1024875 potI 958223 potI Escherichia coli O157:H7 str. EDL933 putrescine ABC transporter membrane protein NP_286623.1 1024030 D 155864 CDS NP_286624.1 15800610 958224 1024935..1025423 1 NC_002655.2 hypothetical protein 1025423 ybjO 958224 ybjO Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286624.1 1024935 D 155864 CDS NP_286625.1 15800611 958225 1025464..1026591 1 NC_002655.2 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 1026591 rumB 958225 rumB Escherichia coli O157:H7 str. EDL933 23S rRNA methyluridine methyltransferase NP_286625.1 1025464 D 155864 CDS NP_286626.1 15800612 958237 1026871..1028214 1 NC_002655.2 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 1028214 ulaA 958237 ulaA Escherichia coli O157:H7 str. EDL933 PTS system ascorbate-specific transporter subunit IIC NP_286626.1 1026871 D 155864 CDS NP_286627.1 15800613 958238 1028236..1028556 1 NC_002655.2 hypothetical protein 1028556 958238 Z1088 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286627.1 1028236 D 155864 CDS NP_286628.1 15800614 958249 1028568..1030049 1 NC_002655.2 sulfatase 1030049 958249 Z1089 Escherichia coli O157:H7 str. EDL933 sulfatase NP_286628.1 1028568 D 155864 CDS NP_286629.1 15800615 958254 complement(1030100..1030882) 1 NC_002655.2 arginine ABC transporter substrate-binding protein 1030882 artJ 958254 artJ Escherichia coli O157:H7 str. EDL933 arginine ABC transporter substrate-binding protein NP_286629.1 1030100 R 155864 CDS NP_286630.1 15800616 958255 complement(1031122..1031790) 1 NC_002655.2 with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease subunit ArtM 1031790 artM 958255 artM Escherichia coli O157:H7 str. EDL933 arginine transporter permease subunit ArtM NP_286630.1 1031122 R 155864 CDS NP_286631.1 15800617 958269 complement(1031790..1032506) 1 NC_002655.2 with ArtPMJI transports arginine across the inner membrane; arginine transporter permease subunit ArtQ 1032506 artQ 958269 artQ Escherichia coli O157:H7 str. EDL933 arginine transporter permease subunit ArtQ NP_286631.1 1031790 R 155864 CDS NP_286632.1 15800618 958271 complement(1032513..1033244) 1 NC_002655.2 arginine ABC transporter substrate-binding protein 1033244 artI 958271 artI Escherichia coli O157:H7 str. EDL933 arginine ABC transporter substrate-binding protein NP_286632.1 1032513 R 155864 CDS NP_286633.1 15800619 958275 complement(1033262..1033990) 1 NC_002655.2 With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding subunit 1033990 artP 958275 artP Escherichia coli O157:H7 str. EDL933 arginine transporter ATP-binding subunit NP_286633.1 1033262 R 155864 CDS NP_286634.1 15800620 958281 complement(1034208..1034729) 1 NC_002655.2 induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS; lipoprotein 1034729 ybjP 958281 ybjP Escherichia coli O157:H7 str. EDL933 lipoprotein NP_286634.1 1034208 R 155864 CDS NP_286635.1 15800621 958283 complement(1034737..1034919) 1 NC_002655.2 No significant matches; hypothetical protein 1034919 958283 Z1096 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286635.1 1034737 R 155864 CDS NP_286636.1 15800622 958293 1035348..1036589 1 NC_002655.2 No significant matches; hypothetical protein 1036589 958293 Z1097 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286636.1 1035348 D 155864 CDS NP_286637.1 15800623 958306 1036699..1037154 1 NC_002655.2 No significant matches; hypothetical protein 1037154 958306 Z1098 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286637.1 1036699 D 155864 CDS NP_286638.1 15800624 958317 1037365..1037688 1 NC_002655.2 hypothetical protein 1037688 958317 Z1099 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286638.1 1037365 D 155864 CDS NP_286639.1 15800625 958329 1037685..1038515 1 NC_002655.2 regulator 1038515 958329 Z1100 Escherichia coli O157:H7 str. EDL933 regulator NP_286639.1 1037685 D 155864 CDS NP_286640.1 15800626 958348 complement(1038512..1039561) 1 NC_002655.2 nucleotide di-P-sugar epimerase or dehydratase 1039561 958348 Z1102 Escherichia coli O157:H7 str. EDL933 nucleotide di-P-sugar epimerase or dehydratase NP_286640.1 1038512 R 155864 CDS NP_286641.1 15800627 958350 complement(1039624..1041054) 1 NC_002655.2 dTDP-glucose enzyme 1041054 ybjT 958350 ybjT Escherichia coli O157:H7 str. EDL933 dTDP-glucose enzyme NP_286641.1 1039624 R 155864 CDS NP_286642.1 15800628 958351 complement(1041065..1042066) 1 NC_002655.2 low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine; L-threonine aldolase 1042066 ybjU 958351 ybjU Escherichia coli O157:H7 str. EDL933 L-threonine aldolase NP_286642.1 1041065 R 155864 CDS NP_286643.1 15800629 958381 complement(1042103..1043821) 1 NC_002655.2 catalyzes the formation of acetate from pyruvate; pyruvate dehydrogenase 1043821 poxB 958381 poxB Escherichia coli O157:H7 str. EDL933 pyruvate dehydrogenase NP_286643.1 1042103 R 155864 CDS NP_286644.1 15800630 958384 complement(1043954..1044922) 1 NC_002655.2 HCP oxidoreductase 1044922 958384 Z1106 Escherichia coli O157:H7 str. EDL933 HCP oxidoreductase NP_286644.1 1043954 R 155864 CDS NP_286645.2 161367629 958391 complement(1044934..1046586) 1 NC_002655.2 catalyzes the reduction of hydroxylamine to ammonia and water; hydroxylamine reductase 1046586 ybjW 958391 ybjW Escherichia coli O157:H7 str. EDL933 hydroxylamine reductase NP_286645.2 1044934 R 155864 CDS NP_286646.1 15800632 958392 complement(1046730..1047629) 1 NC_002655.2 surface protein 1047629 ybjE 958392 ybjE Escherichia coli O157:H7 str. EDL933 surface protein NP_286646.1 1046730 R 155864 CDS NP_286647.1 15800633 958402 complement(1048087..1048782) 1 NC_002655.2 porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure; aquaporin Z 1048782 aqpZ 958402 aqpZ Escherichia coli O157:H7 str. EDL933 aquaporin Z NP_286647.1 1048087 R 155864 CDS NP_286648.1 15800634 958404 1049208..1050866 1 NC_002655.2 hypothetical protein 1050866 ybjD 958404 ybjD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286648.1 1049208 D 155864 CDS NP_286649.1 15800635 958410 complement(1050863..1051855) 1 NC_002655.2 hypothetical protein 1051855 ybjX 958410 ybjX Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286649.1 1050863 R 155864 CDS NP_286650.2 161367628 958411 1051970..1053085 1 NC_002655.2 confers macrolide resistance via active drug efflux; macrolide transporter subunit MacA 1053085 958411 Z1115 Escherichia coli O157:H7 str. EDL933 macrolide transporter subunit MacA NP_286650.2 1051970 D 155864 CDS NP_286651.1 15800637 958415 1053082..1055028 1 NC_002655.2 with MacA is involved in the export of macrolide; macrolide transporter ATP-binding /permease 1055028 ybjZ 958415 ybjZ Escherichia coli O157:H7 str. EDL933 macrolide transporter ATP-binding /permease NP_286651.1 1053082 D 155864 CDS NP_286652.1 15800638 958429 complement(1055101..1055325) 1 NC_002655.2 inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible; stationary phase/starvation inducible regulatory protein CspD 1055325 cspD 958429 cspD Escherichia coli O157:H7 str. EDL933 stationary phase/starvation inducible regulatory protein CspD NP_286652.1 1055101 R 155864 CDS NP_286653.1 15800639 958433 1055648..1055968 1 NC_002655.2 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 1055968 clpS 958433 clpS Escherichia coli O157:H7 str. EDL933 ATP-dependent Clp protease adaptor protein ClpS NP_286653.1 1055648 D 155864 CDS NP_286654.1 15800640 958434 1055999..1058275 1 NC_002655.2 ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates; ATP-dependent Clp protease ATP-binding subunit 1058275 clpA 958434 clpA Escherichia coli O157:H7 str. EDL933 ATP-dependent Clp protease ATP-binding subunit NP_286654.1 1055999 D 155864 CDS NP_286655.1 15800641 958437 1058795..1059997 1 NC_002655.2 P4 family integrase 1059997 958437 Z1120 Escherichia coli O157:H7 str. EDL933 P4 family integrase NP_286655.1 1058795 D 155864 CDS NP_286656.1 15800642 958445 complement(1060184..1062001) 1 NC_002655.2 No significant matches; hypothetical protein 1062001 958445 Z1121 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286656.1 1060184 R 155864 CDS NP_286657.1 15800643 958450 1062369..1062470 1 NC_002655.2 hypothetical protein 1062470 958450 Z1122 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286657.1 1062369 D 155864 CDS NP_286658.1 15800644 958463 1062497..1062934 1 NC_002655.2 hypothetical protein 1062934 958463 Z1123 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286658.1 1062497 D 155864 CDS NP_286659.1 15800645 958484 1063113..1063409 1 NC_002655.2 prophage regulatory protein 1063409 958484 Z1124 Escherichia coli O157:H7 str. EDL933 prophage regulatory protein NP_286659.1 1063113 D 155864 CDS NP_286660.1 15800646 958509 1063636..1063833 1 NC_002655.2 hypothetical protein 1063833 958509 Z1125 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286660.1 1063636 D 155864 CDS NP_286661.1 15800647 958522 1064034..1065437 1 NC_002655.2 hypothetical protein 1065437 958522 Z1126 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286661.1 1064034 D 155864 CDS NP_286663.1 15800649 958524 1066258..1066821 1 NC_002655.2 No significant matches; hypothetical protein 1066821 958524 Z1128 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286663.1 1066258 D 155864 CDS NP_286664.1 15800650 958525 1066952..1069336 1 NC_002655.2 helicase 1069336 958525 Z1129 Escherichia coli O157:H7 str. EDL933 helicase NP_286664.1 1066952 D 155864 CDS NP_286665.1 15800651 958531 complement(1069498..1069767) 1 NC_002655.2 No significant matches; hypothetical protein 1069767 958531 Z1130 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286665.1 1069498 R 155864 CDS NP_286666.1 15800652 958535 complement(1070093..1071631) 1 NC_002655.2 hypothetical protein 1071631 958535 Z1131 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286666.1 1070093 R 155864 CDS NP_286667.1 15800653 958538 complement(1071681..1072028) 1 NC_002655.2 hypothetical protein 1072028 958538 Z1132 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286667.1 1071681 R 155864 CDS NP_286668.1 15800654 958542 complement(1072481..1072792) 1 NC_002655.2 transposase 1072792 958542 Z1133 Escherichia coli O157:H7 str. EDL933 transposase NP_286668.1 1072481 R 155864 CDS NP_286669.1 15800655 958543 1072932..1073750 1 NC_002655.2 hypothetical protein 1073750 958543 Z1134 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286669.1 1072932 D 155864 CDS NP_286670.1 15800656 958544 1073863..1074402 1 NC_002655.2 complement resistance protein 1074402 958544 Z1135 Escherichia coli O157:H7 str. EDL933 complement resistance protein NP_286670.1 1073863 D 155864 CDS NP_286671.1 15800657 958547 complement(1074450..1074743) 1 NC_002655.2 No significant matches; hypothetical protein 1074743 958547 Z1136 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286671.1 1074450 R 155864 CDS NP_286672.1 15800658 958553 complement(1074725..1075015) 1 NC_002655.2 No significant matches; hypothetical protein 1075015 958553 Z1137 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286672.1 1074725 R 155864 CDS NP_286673.1 15800659 958557 1075148..1075222 1 NC_002655.2 No significant matches; hypothetical protein 1075222 958557 Z1138 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286673.1 1075148 D 155864 CDS NP_286674.1 15800660 958566 1075701..1076060 1 NC_002655.2 diacylglycerol kinase 1076060 958566 Z1139 Escherichia coli O157:H7 str. EDL933 diacylglycerol kinase NP_286674.1 1075701 D 155864 CDS NP_286675.1 15800661 958567 complement(1076153..1077772) 1 NC_002655.2 hypothetical protein 1077772 958567 Z1140 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286675.1 1076153 R 155864 CDS NP_286676.1 15800662 958570 complement(1077997..1078278) 1 NC_002655.2 No significant matches; hypothetical protein 1078278 958570 Z1141 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286676.1 1077997 R 155864 CDS NP_286677.1 15800663 958575 1078653..1079351 1 NC_002655.2 urease accessory protein D 1079351 ureD 958575 ureD Escherichia coli O157:H7 str. EDL933 urease accessory protein D NP_286677.1 1078653 D 155864 CDS NP_286678.1 15800664 958577 1079442..1079744 1 NC_002655.2 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; urease subunit gamma 1079744 ureA 958577 ureA Escherichia coli O157:H7 str. EDL933 urease subunit gamma NP_286678.1 1079442 D 155864 CDS NP_286679.1 15800665 958579 1079753..1080073 1 NC_002655.2 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active; urease subunit beta 1080073 ureB 958579 ureB Escherichia coli O157:H7 str. EDL933 urease subunit beta NP_286679.1 1079753 D 155864 CDS NP_286680.1 15800666 958581 1080063..1081769 1 NC_002655.2 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 1081769 ureC 958581 ureC Escherichia coli O157:H7 str. EDL933 urease subunit alpha NP_286680.1 1080063 D 155864 CDS NP_286681.1 15800667 958583 1081779..1082243 1 NC_002655.2 involved in the assembly of the urease metallocenter; possible nickel donor; urease accessory protein UreE 1082243 ureE 958583 ureE Escherichia coli O157:H7 str. EDL933 urease accessory protein UreE NP_286681.1 1081779 D 155864 CDS NP_286682.1 15800668 958588 1082244..1082918 1 NC_002655.2 urease accessory protein F 1082918 ureF 958588 ureF Escherichia coli O157:H7 str. EDL933 urease accessory protein F NP_286682.1 1082244 D 155864 CDS NP_286683.1 15800669 958601 1082930..1083547 1 NC_002655.2 urease accessory protein G 1083547 ureG 958601 ureG Escherichia coli O157:H7 str. EDL933 urease accessory protein G NP_286683.1 1082930 D 155864 CDS NP_286684.1 15800670 958644 complement(1083595..1083726) 1 NC_002655.2 hypothetical protein 1083726 958644 Z1149 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286684.1 1083595 R 155864 CDS NP_286685.1 15800671 958653 complement(1083803..1084144) 1 NC_002655.2 hypothetical protein 1084144 958653 Z1150 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286685.1 1083803 R 155864 CDS NP_286686.1 15800672 958664 complement(1084206..1084334) 1 NC_002655.2 hypothetical protein 1084334 958664 Z1151 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286686.1 1084206 R 155864 CDS NP_286687.1 15800673 958672 1084759..1085022 1 NC_002655.2 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1085022 rpmE2 958672 rpmE2 Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L31 NP_286687.1 1084759 D 155864 CDS NP_286688.1 15800674 958685 1085324..1085464 1 NC_002655.2 No significant matches; hypothetical protein 1085464 958685 Z1153 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286688.1 1085324 D 155864 CDS NP_286689.1 15800675 958700 complement(1085879..1086031) 1 NC_002655.2 No significant matches; hypothetical protein 1086031 958700 Z1154 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286689.1 1085879 R 155864 CDS NP_286690.1 15800676 958705 complement(1086337..1087074) 1 NC_002655.2 No significant matches; hypothetical protein 1087074 958705 Z1155 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286690.1 1086337 R 155864 CDS NP_286691.1 15800677 958708 complement(1087457..1087597) 1 NC_002655.2 No significant matches; hypothetical protein 1087597 958708 Z1156 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286691.1 1087457 R 155864 CDS NP_286692.1 15800678 958710 complement(1088028..1088201) 1 NC_002655.2 No significant matches; hypothetical protein 1088201 958710 Z1157 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286692.1 1088028 R 155864 CDS NP_286693.1 15800679 958711 complement(1088541..1089026) 1 NC_002655.2 hypothetical protein 1089026 958711 Z1158 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286693.1 1088541 R 155864 CDS NP_286694.1 15800680 958712 1089346..1089771 1 NC_002655.2 hypothetical protein 1089771 958712 Z1159 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286694.1 1089346 D 155864 CDS NP_286695.1 15800681 958714 1089768..1090118 1 NC_002655.2 hypothetical protein 1090118 958714 Z1160 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286695.1 1089768 D 155864 CDS NP_286696.1 15800682 958715 1090149..1091762 1 NC_002655.2 hypothetical protein 1091762 958715 Z1161 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286696.1 1090149 D 155864 CDS NP_286697.1 15800683 958717 complement(1091766..1092623) 1 NC_002655.2 hypothetical protein 1092623 958717 Z1162 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286697.1 1091766 R 155864 CDS NP_286698.1 15800684 958719 complement(1092705..1093067) 1 NC_002655.2 hypothetical protein 1093067 958719 Z1163 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286698.1 1092705 R 155864 CDS NP_286699.1 15800685 958721 complement(1093623..1094090) 1 NC_002655.2 hypothetical protein 1094090 terW 958721 terW Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286699.1 1093623 R 155864 CDS NP_286700.1 15800686 958722 complement(1094108..1095316) 1 NC_002655.2 No significant matches; hypothetical protein 1095316 958722 Z1165 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286700.1 1094108 R 155864 CDS NP_286701.1 15800687 958726 complement(1095327..1096283) 1 NC_002655.2 hypothetical protein 1096283 958726 Z1166 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286701.1 1095327 R 155864 CDS NP_286702.1 15800688 958727 complement(1096283..1097398) 1 NC_002655.2 hypothetical protein 1097398 958727 Z1167 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286702.1 1096283 R 155864 CDS NP_286703.1 15800689 958733 complement(1097364..1098359) 1 NC_002655.2 hypothetical protein 1098359 958733 Z1168 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286703.1 1097364 R 155864 CDS NP_286704.1 15800690 958736 complement(1098130..1099272) 1 NC_002655.2 hypothetical protein 1099272 958736 Z1169 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286704.1 1098130 R 155864 CDS NP_286705.1 15800691 958739 complement(1099282..1100340) 1 NC_002655.2 hypothetical protein 1100340 958739 Z1170 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286705.1 1099282 R 155864 CDS NP_286706.1 15800692 958741 1100663..1101244 1 NC_002655.2 phage inhibition, colicin resistance and tellurite resistance protein 1101244 terZ 958741 terZ Escherichia coli O157:H7 str. EDL933 phage inhibition, colicin resistance and tellurite resistance protein NP_286706.1 1100663 D 155864 CDS NP_286707.1 15800693 958742 1101244..1102401 1 NC_002655.2 phage inhibition, colicin resistance and tellurite resistance protein 1102401 terA 958742 terA Escherichia coli O157:H7 str. EDL933 phage inhibition, colicin resistance and tellurite resistance protein NP_286707.1 1101244 D 155864 CDS NP_286708.1 15800694 958743 1102424..1102879 1 NC_002655.2 phage inhibition, colicin resistance and tellurite resistance protein 1102879 terB 958743 terB Escherichia coli O157:H7 str. EDL933 phage inhibition, colicin resistance and tellurite resistance protein NP_286708.1 1102424 D 155864 CDS NP_286709.1 15800695 958744 1102902..1103942 1 NC_002655.2 phage inhibition, colicin resistance and tellurite resistance protein 1103942 terC 958744 terC Escherichia coli O157:H7 str. EDL933 phage inhibition, colicin resistance and tellurite resistance protein NP_286709.1 1102902 D 155864 CDS NP_286710.1 15800696 958745 1103991..1104569 1 NC_002655.2 phage inhibition, colicin resistance and tellurite resistance protein 1104569 terD 958745 terD Escherichia coli O157:H7 str. EDL933 phage inhibition, colicin resistance and tellurite resistance protein NP_286710.1 1103991 D 155864 CDS NP_286711.1 15800697 958747 1104638..1105213 1 NC_002655.2 phage inhibition, colicin resistance and tellurite resistance protein 1105213 terE 958747 terE Escherichia coli O157:H7 str. EDL933 phage inhibition, colicin resistance and tellurite resistance protein NP_286711.1 1104638 D 155864 CDS NP_286712.1 15800698 958749 1105635..1105943 1 NC_002655.2 phage inhibition, colicin resistance and tellurite resistance protein 1105943 terF 958749 terF Escherichia coli O157:H7 str. EDL933 phage inhibition, colicin resistance and tellurite resistance protein NP_286712.1 1105635 D 155864 CDS NP_286713.1 15800699 958751 complement(1106535..1108625) 1 NC_002655.2 IrgA-homologue adhesin (Iha); TonB-dependent; acts as a specific receptor of enterobactin; fur-regulated; urovirulence factor; bifunctional enterobactin receptor/adhesin protein 1108625 958751 Z1178 Escherichia coli O157:H7 str. EDL933 bifunctional enterobactin receptor/adhesin protein NP_286713.1 1106535 R 155864 CDS NP_286715.1 15800701 958753 complement(1109295..1109582) 1 NC_002655.2 No significant matches; hypothetical protein 1109582 958753 Z1180 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286715.1 1109295 R 155864 CDS NP_286716.1 15800702 958754 1110079..1110297 1 NC_002655.2 hypothetical protein 1110297 958754 Z1181 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286716.1 1110079 D 155864 CDS NP_286717.1 15800703 958755 complement(1110699..1110797) 1 NC_002655.2 No significant matches; hypothetical protein 1110797 958755 Z1182 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286717.1 1110699 R 155864 CDS NP_286718.1 15800704 958761 1110930..1111265 1 NC_002655.2 hypothetical protein 1111265 958761 Z1183 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286718.1 1110930 D 155864 CDS NP_286719.1 15800705 958762 1111782..1111916 1 NC_002655.2 No significant matches; hypothetical protein 1111916 958762 Z1184 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286719.1 1111782 D 155864 CDS NP_286720.1 15800706 958764 complement(1112046..1112240) 1 NC_002655.2 No significant matches; hypothetical protein 1112240 958764 Z1185 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286720.1 1112046 R 155864 CDS NP_286721.1 15800707 958765 1112560..1112832 1 NC_002655.2 No significant matches; hypothetical protein 1112832 958765 Z1186 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286721.1 1112560 D 155864 CDS NP_286722.1 15800708 958766 1113224..1113331 1 NC_002655.2 No significant matches; hypothetical protein 1113331 958766 Z1187 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286722.1 1113224 D 155864 CDS NP_286723.1 15800709 958769 1113397..1113594 1 NC_002655.2 No significant matches; hypothetical protein 1113594 958769 Z1188 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286723.1 1113397 D 155864 CDS NP_286724.1 15800710 958771 1113678..1113797 1 NC_002655.2 No significant matches; hypothetical protein 1113797 958771 Z1189 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286724.1 1113678 D 155864 CDS NP_286725.1 15800711 958772 1114324..1115448 1 NC_002655.2 glucosyltransferase 1115448 958772 Z1190 Escherichia coli O157:H7 str. EDL933 glucosyltransferase NP_286725.1 1114324 D 155864 CDS NP_286726.1 15800712 958776 complement(1115590..1115865) 1 NC_002655.2 hypothetical protein 1115865 958776 Z1191 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286726.1 1115590 R 155864 CDS NP_286727.1 15800713 958777 complement(1115867..1116370) 1 NC_002655.2 IS1 protein InsB 1116370 958777 Z1192 Escherichia coli O157:H7 str. EDL933 IS1 protein InsB NP_286727.1 1115867 R 155864 CDS NP_286728.1 15800714 958778 complement(1116802..1117272) 1 NC_002655.2 No significant matches; hypothetical protein 1117272 958778 Z1193 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286728.1 1116802 R 155864 CDS NP_286729.1 15800715 958779 1117718..1118227 1 NC_002655.2 No significant matches; hypothetical protein 1118227 958779 Z1194 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286729.1 1117718 D 155864 CDS NP_286730.1 15800716 958780 1118316..1118939 1 NC_002655.2 No significant matches; hypothetical protein 1118939 958780 Z1195 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286730.1 1118316 D 155864 CDS NP_286731.1 15800717 958781 1119035..1119268 1 NC_002655.2 No significant matches; hypothetical protein 1119268 958781 Z1196 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286731.1 1119035 D 155864 CDS NP_286732.1 15800718 958782 complement(1119321..1119512) 1 NC_002655.2 No significant matches; hypothetical protein 1119512 958782 Z1197 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286732.1 1119321 R 155864 CDS NP_286733.1 15800719 958784 complement(1120106..1120993) 1 NC_002655.2 transposase 1120993 958784 Z1198 Escherichia coli O157:H7 str. EDL933 transposase NP_286733.1 1120106 R 155864 CDS NP_286734.1 15800720 958785 complement(1120993..1121319) 1 NC_002655.2 hypothetical protein 1121319 958785 Z1199 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286734.1 1120993 R 155864 CDS NP_286735.1 15800721 958787 1121500..1122546 1 NC_002655.2 hypothetical protein 1122546 958787 Z1200 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286735.1 1121500 D 155864 CDS NP_286736.1 15800722 958788 1122787..1123302 1 NC_002655.2 No significant matches; hypothetical protein 1123302 958788 Z1201 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286736.1 1122787 D 155864 CDS NP_286737.1 15800723 958789 1123332..1125467 1 NC_002655.2 hypothetical protein 1125467 958789 Z1202 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286737.1 1123332 D 155864 CDS NP_286738.1 15800724 958792 1125968..1127200 1 NC_002655.2 hypothetical protein 1127200 958792 Z1203 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286738.1 1125968 D 155864 CDS NP_286739.1 15800725 958793 1127185..1127823 1 NC_002655.2 hypothetical protein 1127823 958793 Z1204 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286739.1 1127185 D 155864 CDS NP_286740.1 15800726 958794 1128192..1128836 1 NC_002655.2 No significant matches; hypothetical protein 1128836 958794 Z1205 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286740.1 1128192 D 155864 CDS NP_286741.1 15800727 958795 1128884..1129039 1 NC_002655.2 No significant matches; hypothetical protein 1129039 958795 Z1206 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286741.1 1128884 D 155864 CDS NP_286742.1 15800728 958796 complement(1129534..1129782) 1 NC_002655.2 hypothetical protein 1129782 958796 Z1207 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286742.1 1129534 R 155864 CDS NP_286743.1 15800729 958799 1129836..1130261 1 NC_002655.2 hypothetical protein 1130261 958799 Z1208 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286743.1 1129836 D 155864 CDS NP_286744.1 15800730 958800 complement(1130561..1130743) 1 NC_002655.2 No significant matches; hypothetical protein 1130743 958800 Z1209 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286744.1 1130561 R 155864 CDS NP_286745.1 15800731 958806 1131072..1131944 1 NC_002655.2 histone 1131944 958806 Z1210 Escherichia coli O157:H7 str. EDL933 histone NP_286745.1 1131072 D 155864 CDS NP_286746.1 15800732 958808 1132148..1135165 1 NC_002655.2 adhesin 1135165 958808 Z1211 Escherichia coli O157:H7 str. EDL933 adhesin NP_286746.1 1132148 D 155864 CDS NP_286747.1 15800733 958809 1135273..1137660 1 NC_002655.2 hypothetical protein 1137660 958809 Z1212 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286747.1 1135273 D 155864 CDS NP_286748.1 15800734 958810 1137657..1138562 1 NC_002655.2 hypothetical protein 1138562 958810 Z1213 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286748.1 1137657 D 155864 CDS NP_286749.1 15800735 958812 1138559..1139629 1 NC_002655.2 hypothetical protein 1139629 958812 Z1214 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286749.1 1138559 D 155864 CDS NP_286750.1 15800736 958815 1139969..1140787 1 NC_002655.2 hypothetical protein 1140787 958815 Z1215 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286750.1 1139969 D 155864 CDS NP_286751.1 15800737 958816 1140878..1141363 1 NC_002655.2 hypothetical protein 1141363 958816 Z1216 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286751.1 1140878 D 155864 CDS NP_286752.1 15800738 958817 1141379..1141855 1 NC_002655.2 RadC family DNA repair protein 1141855 958817 Z1217 Escherichia coli O157:H7 str. EDL933 RadC family DNA repair protein NP_286752.1 1141379 D 155864 CDS NP_286753.1 15800739 958819 1141918..1142139 1 NC_002655.2 hypothetical protein 1142139 958819 Z1218 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286753.1 1141918 D 155864 CDS NP_286754.1 15800740 958820 1142139..1142252 1 NC_002655.2 No significant matches; hypothetical protein 1142252 958820 Z1219 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286754.1 1142139 D 155864 CDS NP_286755.1 15800741 958821 1142302..1142676 1 NC_002655.2 structural protein 1142676 958821 Z1220 Escherichia coli O157:H7 str. EDL933 structural protein NP_286755.1 1142302 D 155864 CDS NP_286756.1 15800742 958822 complement(1142979..1143866) 1 NC_002655.2 transposase 1143866 958822 Z1221 Escherichia coli O157:H7 str. EDL933 transposase NP_286756.1 1142979 R 155864 CDS NP_286757.1 15800743 958825 complement(1143866..1144192) 1 NC_002655.2 hypothetical protein 1144192 958825 Z1222 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286757.1 1143866 R 155864 CDS NP_286758.1 15800744 958829 1144407..1144898 1 NC_002655.2 hypothetical protein 1144898 958829 Z1223 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286758.1 1144407 D 155864 CDS NP_286759.1 15800745 958835 1144910..1145107 1 NC_002655.2 hypothetical protein 1145107 958835 Z1225 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286759.1 1144910 D 155864 CDS NP_286760.1 15800746 958836 1145192..1146034 1 NC_002655.2 hypothetical protein 1146034 958836 Z1226 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286760.1 1145192 D 155864 CDS NP_286761.1 15800747 958838 complement(1146525..1146743) 1 NC_002655.2 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 1146743 infA 958838 infA Escherichia coli O157:H7 str. EDL933 translation initiation factor IF-1 NP_286761.1 1146525 R 155864 CDS NP_286762.1 15800748 958840 complement(1147028..1147732) 1 NC_002655.2 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys; leucyl/phenylalanyl-tRNA--protein transferase 1147732 aat 958840 aat Escherichia coli O157:H7 str. EDL933 leucyl/phenylalanyl-tRNA--protein transferase NP_286762.1 1147028 R 155864 CDS NP_286763.1 15800749 958841 complement(1147774..1149495) 1 NC_002655.2 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 1149495 cydC 958841 cydC Escherichia coli O157:H7 str. EDL933 cysteine/glutathione ABC transporter membrane/ATP-binding protein NP_286763.1 1147774 R 155864 CDS NP_286764.1 15800750 958845 complement(1149496..1151262) 1 NC_002655.2 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 1151262 cydD 958845 cydD Escherichia coli O157:H7 str. EDL933 cysteine/glutathione ABC transporter membrane/ATP-binding protein NP_286764.1 1149496 R 155864 CDS NP_286765.1 15800751 958846 complement(1151385..1152350) 1 NC_002655.2 catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding; thioredoxin reductase 1152350 trxB 958846 trxB Escherichia coli O157:H7 str. EDL933 thioredoxin reductase NP_286765.1 1151385 R 155864 CDS NP_286766.1 15800752 958847 1152895..1153389 1 NC_002655.2 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator 1153389 lrp 958847 lrp Escherichia coli O157:H7 str. EDL933 leucine-responsive transcriptional regulator NP_286766.1 1152895 D 155864 CDS NP_286767.1 15800753 958848 1153524..1157552 1 NC_002655.2 DNA-binding membrane protein required for chromosome resolution and partitioning; DNA translocase FtsK 1157552 ftsK 958848 ftsK Escherichia coli O157:H7 str. EDL933 DNA translocase FtsK NP_286767.1 1153524 D 155864 CDS NP_286768.1 15800754 958850 1157704..1158318 1 NC_002655.2 participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein 1158318 lolA 958850 lolA Escherichia coli O157:H7 str. EDL933 outer-membrane lipoprotein carrier protein NP_286768.1 1157704 D 155864 CDS NP_286769.1 15800755 958851 1158329..1159672 1 NC_002655.2 recombination factor protein RarA 1159672 ycaJ 958851 ycaJ Escherichia coli O157:H7 str. EDL933 recombination factor protein RarA NP_286769.1 1158329 D 155864 CDS NP_286770.1 15800756 958852 1159763..1161055 1 NC_002655.2 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 1161055 serS 958852 serS Escherichia coli O157:H7 str. EDL933 seryl-tRNA synthetase NP_286770.1 1159763 D 155864 CDS NP_286771.1 15800757 958853 1161381..1163738 1 NC_002655.2 anaerobic dimethyl sulfoxide reductase subunit A 1163738 dmsA 958853 dmsA Escherichia coli O157:H7 str. EDL933 anaerobic dimethyl sulfoxide reductase subunit A NP_286771.1 1161381 D 155864 CDS NP_286772.1 15800758 958857 1163749..1164366 1 NC_002655.2 anaerobic dimethyl sulfoxide reductase subunit B 1164366 dmsB 958857 dmsB Escherichia coli O157:H7 str. EDL933 anaerobic dimethyl sulfoxide reductase subunit B NP_286772.1 1163749 D 155864 CDS NP_286773.1 15800759 958858 1164368..1165231 1 NC_002655.2 anaerobic dimethyl sulfoxide reductase subunit C 1165231 dmsC 958858 dmsC Escherichia coli O157:H7 str. EDL933 anaerobic dimethyl sulfoxide reductase subunit C NP_286773.1 1164368 D 155864 CDS NP_286774.1 15800760 958860 complement(1165267..1165893) 1 NC_002655.2 hypothetical protein 1165893 ycaC 958860 ycaC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286774.1 1165267 R 155864 CDS NP_286775.1 15800761 958861 1166208..1167356 1 NC_002655.2 MFS family transporter protein 1167356 ycaD 958861 ycaD Escherichia coli O157:H7 str. EDL933 MFS family transporter protein NP_286775.1 1166208 D 155864 CDS NP_286776.1 15800762 958862 1167374..1168996 1 NC_002655.2 transport 1168996 958862 Z1245 Escherichia coli O157:H7 str. EDL933 transport NP_286776.1 1167374 D 155864 CDS NP_286777.1 15800763 958863 complement(1169206..1169946) 1 NC_002655.2 activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 1 1169946 pflA 958863 pflA Escherichia coli O157:H7 str. EDL933 pyruvate formate lyase-activating enzyme 1 NP_286777.1 1169206 R 155864 CDS NP_286778.1 15800764 958864 complement(1170138..1172420) 1 NC_002655.2 formate acetyltransferase 1 1172420 pflB 958864 pflB Escherichia coli O157:H7 str. EDL933 formate acetyltransferase 1 NP_286778.1 1170138 R 155864 CDS NP_286779.1 15800765 958866 complement(1172475..1173332) 1 NC_002655.2 formate transporter 1173332 focA 958866 focA Escherichia coli O157:H7 str. EDL933 formate transporter NP_286779.1 1172475 R 155864 CDS NP_286780.1 15800766 958867 complement(1173738..1175507) 1 NC_002655.2 hypothetical protein 1175507 ycaO 958867 ycaO Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286780.1 1173738 R 155864 CDS NP_286781.1 15800767 958868 1175628..1176320 1 NC_002655.2 hypothetical protein 1176320 ycaP 958868 ycaP Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286781.1 1175628 D 155864 CDS NP_286782.1 15800768 958869 1176519..1177607 1 NC_002655.2 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 1177607 serC 958869 serC Escherichia coli O157:H7 str. EDL933 phosphoserine aminotransferase NP_286782.1 1176519 D 155864 CDS NP_286783.1 15800769 958870 1177678..1178961 1 NC_002655.2 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 1178961 aroA 958870 aroA Escherichia coli O157:H7 str. EDL933 3-phosphoshikimate 1-carboxyvinyltransferase NP_286783.1 1177678 D 155864 CDS NP_286784.1 15800770 958871 1179106..1179894 1 NC_002655.2 heat shock protein 1179894 ycaL 958871 ycaL Escherichia coli O157:H7 str. EDL933 heat shock protein NP_286784.1 1179106 D 155864 CDS NP_286785.1 15800771 958872 1180067..1180750 1 NC_002655.2 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1180750 cmk 958872 cmk Escherichia coli O157:H7 str. EDL933 cytidylate kinase NP_286785.1 1180067 D 155864 CDS NP_286786.1 15800772 958873 1180861..1182534 1 NC_002655.2 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1182534 rpsA 958873 rpsA Escherichia coli O157:H7 str. EDL933 30S ribosomal protein S1 NP_286786.1 1180861 D 155864 CDS NP_286787.1 15800773 958874 1182694..1182978 1 NC_002655.2 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 1182978 ihfB 958874 ihfB Escherichia coli O157:H7 str. EDL933 integration host factor subunit beta NP_286787.1 1182694 D 155864 CDS NP_286788.2 161367627 958876 1183185..1185449 1 NC_002655.2 hypothetical protein 1185449 ycaI 958876 ycaI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286788.2 1183185 D 155864 CDS NP_286789.1 15800775 958877 1185486..1187234 1 NC_002655.2 involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding protein/permease 1187234 msbA 958877 msbA Escherichia coli O157:H7 str. EDL933 lipid transporter ATP-binding protein/permease NP_286789.1 1185486 D 155864 CDS NP_286790.1 15800776 958878 1187231..1188217 1 NC_002655.2 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 1188217 lpxK 958878 lpxK Escherichia coli O157:H7 str. EDL933 tetraacyldisaccharide 4'-kinase NP_286790.1 1187231 D 155864 CDS NP_286791.1 15800777 958879 1188254..1189486 1 NC_002655.2 hypothetical protein 1189486 ycaQ 958879 ycaQ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286791.1 1188254 D 155864 CDS NP_286792.1 15800778 958880 1189538..1189720 1 NC_002655.2 hypothetical protein 1189720 ycaR 958880 ycaR Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286792.1 1189538 D 155864 CDS NP_286793.1 15800779 958882 1189717..1190463 1 NC_002655.2 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 1190463 kdsB 958882 kdsB Escherichia coli O157:H7 str. EDL933 3-deoxy-manno-octulosonate cytidylyltransferase NP_286793.1 1189717 D 155864 CDS NP_286794.1 15800780 958883 1190617..1191510 1 NC_002655.2 hypothetical protein 1191510 958883 Z1265 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286794.1 1190617 D 155864 CDS NP_286795.1 15800781 958886 complement(1191487..1192266) 1 NC_002655.2 hypothetical protein 1192266 ycbC 958886 ycbC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286795.1 1191487 R 155864 CDS NP_286796.1 15800782 958887 1192402..1193187 1 NC_002655.2 involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA; metallothionein SmtA 1193187 smtA 958887 smtA Escherichia coli O157:H7 str. EDL933 metallothionein SmtA NP_286796.1 1192402 D 155864 CDS NP_286797.1 15800783 958891 1193184..1194506 1 NC_002655.2 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F 1194506 mukF 958891 mukF Escherichia coli O157:H7 str. EDL933 condesin subunit F NP_286797.1 1193184 D 155864 CDS NP_286798.1 15800784 958893 1194514..1195191 1 NC_002655.2 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E 1195191 mukE 958893 mukE Escherichia coli O157:H7 str. EDL933 condesin subunit E NP_286798.1 1194514 D 155864 CDS NP_286799.1 15800785 958894 1195191..1199651 1 NC_002655.2 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB 1199651 mukB 958894 mukB Escherichia coli O157:H7 str. EDL933 cell division protein MukB NP_286799.1 1195191 D 155864 CDS NP_286800.1 15800786 958895 1199912..1201759 1 NC_002655.2 hypothetical protein 1201759 ycbB 958895 ycbB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286800.1 1199912 D 155864 CDS NP_286801.1 15800787 958899 1201940..1202488 1 NC_002655.2 hypothetical protein 1202488 ycbK 958899 ycbK Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286801.1 1201940 D 155864 CDS NP_286802.1 15800788 958903 1202515..1203162 1 NC_002655.2 hypothetical protein 1203162 ycbL 958903 ycbL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286802.1 1202515 D 155864 CDS NP_286803.1 15800789 958904 complement(1203213..1204403) 1 NC_002655.2 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 1204403 aspC 958904 aspC Escherichia coli O157:H7 str. EDL933 aromatic amino acid aminotransferase NP_286803.1 1203213 R 155864 CDS NP_286804.1 15800790 958905 complement(1204588..1205676) 1 NC_002655.2 outer membrane porin F; 1a; Ia; b; outer membrane protein F 1205676 ompF 958905 ompF Escherichia coli O157:H7 str. EDL933 outer membrane protein F NP_286804.1 1204588 R 155864 CDS NP_286805.1 15800791 958907 complement(1206279..1207679) 1 NC_002655.2 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 1207679 asnC 958907 asnC Escherichia coli O157:H7 str. EDL933 asparaginyl-tRNA synthetase NP_286805.1 1206279 R 155864 CDS NP_286806.1 15800792 958910 complement(1207848..1209050) 1 NC_002655.2 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 1209050 pncB 958910 pncB Escherichia coli O157:H7 str. EDL933 nicotinate phosphoribosyltransferase NP_286806.1 1207848 R 155864 CDS NP_286807.1 15800793 958912 1209316..1211928 1 NC_002655.2 aminopeptidase 1211928 pepN 958912 pepN Escherichia coli O157:H7 str. EDL933 aminopeptidase NP_286807.1 1209316 D 155864 CDS NP_286808.1 15800794 958914 complement(1211971..1212738) 1 NC_002655.2 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease; aliphatic sulfonates transport ATP-binding subunit 1212738 ssuB 958914 ssuB Escherichia coli O157:H7 str. EDL933 aliphatic sulfonates transport ATP-binding subunit NP_286808.1 1211971 R 155864 CDS NP_286809.1 15800795 958915 complement(1212735..1213526) 1 NC_002655.2 part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter permease 1213526 ssuC 958915 ssuC Escherichia coli O157:H7 str. EDL933 alkanesulfonate transporter permease NP_286809.1 1212735 R 155864 CDS NP_286810.1 15800796 958916 complement(1213538..1214683) 1 NC_002655.2 catalyzes the release of sulfite from alkanesulfonates; alkanesulfonate monooxygenase 1214683 ycbN 958916 ycbN Escherichia coli O157:H7 str. EDL933 alkanesulfonate monooxygenase NP_286810.1 1213538 R 155864 CDS NP_286811.2 161367626 958917 complement(1214680..1215639) 1 NC_002655.2 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter substrate-binding subunit 1215639 ycbO 958917 ycbO Escherichia coli O157:H7 str. EDL933 alkanesulfonate transporter substrate-binding subunit NP_286811.2 1214680 R 155864 CDS NP_286812.1 15800798 958918 complement(1215632..1216207) 1 NC_002655.2 NAD(P)H-dependent FMN reductase 1216207 ycbP 958918 ycbP Escherichia coli O157:H7 str. EDL933 NAD(P)H-dependent FMN reductase NP_286812.1 1215632 R 155864 CDS NP_286813.1 15800799 958919 1216554..1217102 1 NC_002655.2 fimbrial-like protein 1217102 ycbQ 958919 ycbQ Escherichia coli O157:H7 str. EDL933 fimbrial-like protein NP_286813.1 1216554 D 155864 CDS NP_286814.1 15800800 958920 1217185..1217886 1 NC_002655.2 chaperone 1217886 ycbR 958920 ycbR Escherichia coli O157:H7 str. EDL933 chaperone NP_286814.1 1217185 D 155864 CDS NP_286815.1 15804976 959649 join(1217911..1218402,1218402..1220510) 1 NC_002655.2 PapC-like porin protein involved in fimbrial biogenesis 1220510 959649 Z1288m Escherichia coli O157:H7 str. EDL933 PapC-like porin protein involved in fimbrial biogenesis NP_286815.1 1217911 D 155864 CDS NP_286816.1 15800801 958921 1220501..1221481 1 NC_002655.2 fimbrial protein 1221481 958921 Z1290 Escherichia coli O157:H7 str. EDL933 fimbrial protein NP_286816.1 1220501 D 155864 CDS NP_286817.1 15800802 958922 1221650..1222126 1 NC_002655.2 hypothetical protein 1222126 958922 Z1291 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286817.1 1221650 D 155864 CDS NP_286818.1 15800803 958924 1222086..1222649 1 NC_002655.2 fimbrial-like protein 1222649 958924 Z1292 Escherichia coli O157:H7 str. EDL933 fimbrial-like protein NP_286818.1 1222086 D 155864 CDS NP_286819.1 15804987 959630 join(1222615..1223085,1223085..1223351) 1 NC_002655.2 pili assembly chaperone 1223351 ycbF 959630 ycbF Escherichia coli O157:H7 str. EDL933 pili assembly chaperone NP_286819.1 1222615 D 155864 CDS NP_286820.1 15800804 958925 1223462..1224472 1 NC_002655.2 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 1224472 pyrD 958925 pyrD Escherichia coli O157:H7 str. EDL933 dihydroorotate dehydrogenase 2 NP_286820.1 1223462 D 155864 CDS NP_286821.1 15800805 958929 1224610..1225188 1 NC_002655.2 hypothetical protein 1225188 ycbW 958929 ycbW Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286821.1 1224610 D 155864 CDS NP_286822.1 15800806 958930 complement(1225185..1226294) 1 NC_002655.2 hypothetical protein 1226294 958930 Z1297 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286822.1 1225185 R 155864 CDS NP_286823.1 15800807 958931 1226538..1228646 1 NC_002655.2 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 1228646 rlmL 958931 rlmL Escherichia coli O157:H7 str. EDL933 23S rRNA m(2)G2445 methyltransferase NP_286823.1 1226538 D 155864 CDS NP_286824.1 15800808 958932 1228658..1230565 1 NC_002655.2 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase 1230565 uup 958932 uup Escherichia coli O157:H7 str. EDL933 ABC transporter ATPase NP_286824.1 1228658 D 155864 CDS NP_286825.1 15800809 958933 1230695..1231948 1 NC_002655.2 paraquat-inducible protein A 1231948 pqiA 958933 pqiA Escherichia coli O157:H7 str. EDL933 paraquat-inducible protein A NP_286825.1 1230695 D 155864 CDS NP_286826.1 15800810 958934 1231953..1233593 1 NC_002655.2 paraquat-inducible protein B 1233593 pqiB 958934 pqiB Escherichia coli O157:H7 str. EDL933 paraquat-inducible protein B NP_286826.1 1231953 D 155864 CDS NP_286827.1 15800811 958935 1233605..1234153 1 NC_002655.2 hypothetical protein 1234153 ymbA 958935 ymbA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286827.1 1233605 D 155864 CDS NP_286828.1 15800812 958936 1234409..1234576 1 NC_002655.2 ribosome modulation factor 1234576 rmf 958936 rmf Escherichia coli O157:H7 str. EDL933 ribosome modulation factor NP_286828.1 1234409 D 155864 CDS NP_286829.1 15800813 958939 complement(1234646..1235164) 1 NC_002655.2 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-ACP dehydratase 1235164 fabA 958939 fabA Escherichia coli O157:H7 str. EDL933 3-hydroxydecanoyl-ACP dehydratase NP_286829.1 1234646 R 155864 CDS NP_286830.1 15800814 958940 complement(1235233..1236993) 1 NC_002655.2 ATP-dependent protease 1236993 958940 Z1305 Escherichia coli O157:H7 str. EDL933 ATP-dependent protease NP_286830.1 1235233 R 155864 CDS NP_286831.1 15800815 958945 1237179..1237631 1 NC_002655.2 hypothetical protein 1237631 ycbG 958945 ycbG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286831.1 1237179 D 155864 CDS NP_286832.1 15800816 958948 complement(1237707..1238747) 1 NC_002655.2 OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d; outer membrane protein OmpA 1238747 ompA 958948 ompA Escherichia coli O157:H7 str. EDL933 outer membrane protein OmpA NP_286832.1 1237707 R 155864 CDS NP_286833.1 15800817 958949 complement(1239104..1239613) 1 NC_002655.2 SOS cell division inhibitor 1239613 sulA 958949 sulA Escherichia coli O157:H7 str. EDL933 SOS cell division inhibitor NP_286833.1 1239104 R 155864 CDS NP_286834.1 15800818 958950 1239832..1240461 1 NC_002655.2 hypothetical protein 1240461 958950 Z1309 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286834.1 1239832 D 155864 CDS NP_286835.1 15800819 958951 complement(1240424..1242586) 1 NC_002655.2 hypothetical protein 1242586 958951 Z1311 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286835.1 1240424 R 155864 CDS NP_286836.1 15800820 958952 complement(1242596..1243042) 1 NC_002655.2 hypothetical protein 1243042 yccF 958952 yccF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286836.1 1242596 R 155864 CDS NP_286837.1 15800821 958954 1243165..1245219 1 NC_002655.2 catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand; DNA helicase IV 1245219 helD 958954 helD Escherichia coli O157:H7 str. EDL933 DNA helicase IV NP_286837.1 1243165 D 155864 CDS NP_286838.2 161367625 958955 complement(1245251..1245709) 1 NC_002655.2 catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase 1245709 mgsA 958955 mgsA Escherichia coli O157:H7 str. EDL933 methylglyoxal synthase NP_286838.2 1245251 R 155864 CDS NP_286839.1 15800823 958959 complement(1245805..1246467) 1 NC_002655.2 hypothetical protein 1246467 958959 Z1315 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286839.1 1245805 R 155864 CDS NP_286840.1 15800824 958960 1246640..1247053 1 NC_002655.2 hypothetical protein 1247053 958960 Z1317 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286840.1 1246640 D 155864 CDS NP_286841.1 15800825 958962 complement(1247098..1247466) 1 NC_002655.2 heat shock protein HspQ 1247466 yccV 958962 yccV Escherichia coli O157:H7 str. EDL933 heat shock protein HspQ NP_286841.1 1247098 R 155864 CDS NP_286842.1 15800826 958963 complement(1247473..1248576) 1 NC_002655.2 oxidoreductase 1248576 958963 Z1319 Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_286842.1 1247473 R 155864 CDS NP_286843.1 15800827 958964 1248758..1249036 1 NC_002655.2 catalyzes the hydrolysis of acylphosphate; acylphosphatase 1249036 958964 Z1320 Escherichia coli O157:H7 str. EDL933 acylphosphatase NP_286843.1 1248758 D 155864 CDS NP_286844.2 161367624 958965 complement(1249033..1249362) 1 NC_002655.2 transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein TusE 1249362 yccK 958965 yccK Escherichia coli O157:H7 str. EDL933 sulfur transfer protein TusE NP_286844.2 1249033 R 155864 CDS NP_286845.1 15800829 958966 complement(1249453..1250112) 1 NC_002655.2 hypothetical protein 1250112 yccA 958966 yccA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286845.1 1249453 R 155864 CDS NP_286846.1 15800830 958967 complement(1250521..1251540) 1 NC_002655.2 integrase for cryptic prophage CP-933M 1251540 958967 Z1323 Escherichia coli O157:H7 str. EDL933 integrase for cryptic prophage CP-933M NP_286846.1 1250521 R 155864 CDS NP_286847.1 15800831 958968 complement(1251828..1254299) 1 NC_002655.2 exodeoxyribonuclease VIII 1254299 958968 Z1324 Escherichia coli O157:H7 str. EDL933 exodeoxyribonuclease VIII NP_286847.1 1251828 R 155864 CDS NP_286848.1 15800832 958969 complement(1254393..1254584) 1 NC_002655.2 hypothetical protein 1254584 958969 Z1325 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286848.1 1254393 R 155864 CDS NP_286849.1 15800833 958970 complement(1254581..1254769) 1 NC_002655.2 inhibitor of cell division encoded by cryptic prophage CP-933M 1254769 958970 Z1326 Escherichia coli O157:H7 str. EDL933 inhibitor of cell division encoded by cryptic prophage CP-933M NP_286849.1 1254581 R 155864 CDS NP_286850.1 15800834 958973 1255272..1255529 1 NC_002655.2 No significant matches; hypothetical protein 1255529 958973 Z1328 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286850.1 1255272 D 155864 CDS NP_286851.1 15800835 958974 complement(1255716..1256105) 1 NC_002655.2 No significant matches; hypothetical protein 1256105 958974 Z1329 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286851.1 1255716 R 155864 CDS NP_286852.1 15800836 958975 complement(1256117..1256254) 1 NC_002655.2 hypothetical protein 1256254 958975 Z1330 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286852.1 1256117 R 155864 CDS NP_286853.1 15800837 958976 complement(1256247..1256402) 1 NC_002655.2 hypothetical protein 1256402 958976 Z1331 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286853.1 1256247 R 155864 CDS NP_286854.1 15800838 958977 complement(1256967..1257158) 1 NC_002655.2 No significant matches; hypothetical protein 1257158 958977 Z1332 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286854.1 1256967 R 155864 CDS NP_286855.1 15800839 958978 complement(1257186..1257584) 1 NC_002655.2 DicA, regulator of DicB; encoded within cryptic prophage CP-933M 1257584 958978 Z1333 Escherichia coli O157:H7 str. EDL933 DicA, regulator of DicB; encoded within cryptic prophage CP-933M NP_286855.1 1257186 R 155864 CDS NP_286856.1 15800840 958979 1257696..1257968 1 NC_002655.2 No significant matches; hypothetical protein 1257968 958979 Z1334 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286856.1 1257696 D 155864 CDS NP_286857.1 15800841 958980 1257952..1258377 1 NC_002655.2 hypothetical protein 1258377 958980 Z1335 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286857.1 1257952 D 155864 CDS NP_286858.1 15800842 958981 1258343..1258900 1 NC_002655.2 No significant matches; hypothetical protein 1258900 958981 Z1336 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286858.1 1258343 D 155864 CDS NP_286859.1 15800843 958982 1259007..1260209 1 NC_002655.2 No significant matches; hypothetical protein 1260209 958982 Z1337 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286859.1 1259007 D 155864 CDS NP_286860.1 15800844 958983 1260216..1260962 1 NC_002655.2 acts to load the DnaB helicase onto the intiation site durning DNA replication; replication protein 1260962 958983 Z1338 Escherichia coli O157:H7 str. EDL933 replication protein NP_286860.1 1260216 D 155864 CDS NP_286861.1 15800845 958984 1260984..1261754 1 NC_002655.2 hypothetical protein 1261754 958984 Z1339 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286861.1 1260984 D 155864 CDS NP_286862.1 15800846 958985 1261770..1262183 1 NC_002655.2 No significant matches; hypothetical protein 1262183 958985 Z1340 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286862.1 1261770 D 155864 CDS NP_286863.1 15800847 958986 complement(1262535..1263308) 1 NC_002655.2 hypothetical protein 1263308 958986 Z1341 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286863.1 1262535 R 155864 CDS NP_286864.1 15800848 958987 1263856..1264068 1 NC_002655.2 cell killing protein encoded within cryptic prophage CP-933M 1264068 958987 Z1342 Escherichia coli O157:H7 str. EDL933 cell killing protein encoded within cryptic prophage CP-933M NP_286864.1 1263856 D 155864 CDS NP_286865.1 15800849 958988 1264516..1265565 1 NC_002655.2 hypothetical protein 1265565 958988 Z1343 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286865.1 1264516 D 155864 CDS NP_286866.1 15800850 958989 1265578..1265952 1 NC_002655.2 endonuclease of cryptic prophage CP-933M 1265952 958989 Z1344 Escherichia coli O157:H7 str. EDL933 endonuclease of cryptic prophage CP-933M NP_286866.1 1265578 D 155864 CDS NP_286867.1 15800851 958990 1265949..1266770 1 NC_002655.2 antitermination protein Q 1266770 958990 Z1345 Escherichia coli O157:H7 str. EDL933 antitermination protein Q NP_286867.1 1265949 D 155864 CDS NP_286869.1 15800853 958992 1267098..1267370 1 NC_002655.2 No significant matches; hypothetical protein 1267370 958992 Z1347 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286869.1 1267098 D 155864 CDS NP_286870.1 15800854 958993 1267367..1267534 1 NC_002655.2 No significant matches; hypothetical protein 1267534 958993 Z1348 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286870.1 1267367 D 155864 CDS NP_286871.1 15800855 958994 1267849..1269699 1 NC_002655.2 hypothetical protein 1269699 958994 Z1349 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286871.1 1267849 D 155864 CDS NP_286872.1 15800856 958995 1270148..1270354 1 NC_002655.2 holin protein of cryptic prophage CP-933M 1270354 958995 Z1350 Escherichia coli O157:H7 str. EDL933 holin protein of cryptic prophage CP-933M NP_286872.1 1270148 D 155864 CDS NP_286873.1 15800857 958996 1270356..1270703 1 NC_002655.2 hypothetical protein 1270703 958996 Z1351 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286873.1 1270356 D 155864 CDS NP_286874.1 15800858 958997 1270754..1271104 1 NC_002655.2 endolysin of cryptic prophage CP-933M 1271104 958997 Z1352 Escherichia coli O157:H7 str. EDL933 endolysin of cryptic prophage CP-933M NP_286874.1 1270754 D 155864 CDS NP_286875.1 15800859 958998 1271559..1272128 1 NC_002655.2 antirepressor protein of cryptic prophage CP-933M 1272128 958998 Z1353 Escherichia coli O157:H7 str. EDL933 antirepressor protein of cryptic prophage CP-933M NP_286875.1 1271559 D 155864 CDS NP_286876.1 15800860 959000 1272282..1272749 1 NC_002655.2 endopeptidase of cryptic prophage CP-933M 1272749 959000 Z1354 Escherichia coli O157:H7 str. EDL933 endopeptidase of cryptic prophage CP-933M NP_286876.1 1272282 D 155864 CDS NP_286877.1 15800861 959001 complement(1273112..1273339) 1 NC_002655.2 hypothetical protein 1273339 959001 Z1355 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286877.1 1273112 R 155864 CDS NP_286878.1 15800862 959002 1273463..1273747 1 NC_002655.2 No significant matches; hypothetical protein 1273747 959002 Z1356 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286878.1 1273463 D 155864 CDS NP_286879.1 15800863 959003 1274037..1274600 1 NC_002655.2 No significant matches; hypothetical protein 1274600 959003 Z1357 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286879.1 1274037 D 155864 CDS NP_286880.1 15800864 959004 1274597..1275853 1 NC_002655.2 hypothetical protein 1275853 959004 Z1358 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286880.1 1274597 D 155864 CDS NP_286881.1 15800865 959005 1275708..1276259 1 NC_002655.2 hypothetical protein 1276259 959005 Z1359 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286881.1 1275708 D 155864 CDS NP_286882.1 15800866 959006 1276323..1278260 1 NC_002655.2 hypothetical protein 1278260 959006 Z1360 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286882.1 1276323 D 155864 CDS NP_286883.1 15800867 959007 1278305..1278526 1 NC_002655.2 No significant matches; hypothetical protein 1278526 959007 Z1361 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286883.1 1278305 D 155864 CDS NP_286884.1 15800868 959008 1278472..1279017 1 NC_002655.2 No significant matches; hypothetical protein 1279017 959008 Z1362 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286884.1 1278472 D 155864 CDS NP_286885.1 15800869 959009 1279288..1279839 1 NC_002655.2 hypothetical protein 1279839 959009 Z1363 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286885.1 1279288 D 155864 CDS NP_286886.1 15800870 959010 1279836..1280240 1 NC_002655.2 No significant matches; hypothetical protein 1280240 959010 Z1364 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286886.1 1279836 D 155864 CDS NP_286887.1 15800871 959011 1280274..1281224 1 NC_002655.2 No significant matches; hypothetical protein 1281224 959011 Z1365 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286887.1 1280274 D 155864 CDS NP_286888.1 15800872 959012 1281221..1281547 1 NC_002655.2 No significant matches; hypothetical protein 1281547 959012 Z1366 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286888.1 1281221 D 155864 CDS NP_286889.1 15800873 959013 1281704..1281907 1 NC_002655.2 hypothetical protein 1281907 959013 Z1367 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286889.1 1281704 D 155864 CDS NP_286890.1 15800874 959014 1281904..1282350 1 NC_002655.2 hypothetical protein 1282350 959014 Z1368 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286890.1 1281904 D 155864 CDS NP_286891.1 15800875 959015 1282347..1282691 1 NC_002655.2 hypothetical protein 1282691 959015 Z1369 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286891.1 1282347 D 155864 CDS NP_286892.1 15800876 959016 1282688..1283467 1 NC_002655.2 tail component encoded by cryptic prophage CP-933M 1283467 959016 Z1370 Escherichia coli O157:H7 str. EDL933 tail component encoded by cryptic prophage CP-933M NP_286892.1 1282688 D 155864 CDS NP_286893.1 15800877 959017 1283473..1283847 1 NC_002655.2 tail assembly chaperone encoded by cryptic prophage CP-933M 1283847 959017 Z1371 Escherichia coli O157:H7 str. EDL933 tail assembly chaperone encoded by cryptic prophage CP-933M NP_286893.1 1283473 D 155864 CDS NP_286894.1 15800878 959018 1283871..1284152 1 NC_002655.2 hypothetical protein 1284152 959018 Z1372 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286894.1 1283871 D 155864 CDS NP_286895.1 15800879 959019 1284423..1285205 1 NC_002655.2 hypothetical protein 1285205 959019 Z1373 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286895.1 1284423 D 155864 CDS NP_286896.1 15800880 959020 1285072..1285407 1 NC_002655.2 hypothetical protein 1285407 959020 Z1374 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286896.1 1285072 D 155864 CDS NP_286897.1 15800881 959021 1285628..1286059 1 NC_002655.2 tail component encoded by cryptic prophage CP-933M; partial 1286059 959021 Z1375 Escherichia coli O157:H7 str. EDL933 tail component encoded by cryptic prophage CP-933M; partial NP_286897.1 1285628 D 155864 CDS NP_286898.1 15800882 959022 1286065..1286235 1 NC_002655.2 tail component encoded by cryptic prophage CP-933M; partial 1286235 959022 Z1376 Escherichia coli O157:H7 str. EDL933 tail component encoded by cryptic prophage CP-933M; partial NP_286898.1 1286065 D 155864 CDS NP_286899.1 15800883 959023 1286409..1286927 1 NC_002655.2 tail component encoded by cryptic prophage CP-933M 1286927 959023 Z1377 Escherichia coli O157:H7 str. EDL933 tail component encoded by cryptic prophage CP-933M NP_286899.1 1286409 D 155864 CDS NP_286900.1 15800884 959024 1286761..1287663 1 NC_002655.2 tail component encoded by cryptic prophage CP-933M; partial 1287663 959024 Z1378 Escherichia coli O157:H7 str. EDL933 tail component encoded by cryptic prophage CP-933M; partial NP_286900.1 1286761 D 155864 CDS NP_286901.1 15800885 959025 1288074..1289009 1 NC_002655.2 tail component encoded by cryptic prophage CP-933M; partial 1289009 959025 Z1379 Escherichia coli O157:H7 str. EDL933 tail component encoded by cryptic prophage CP-933M; partial NP_286901.1 1288074 D 155864 CDS NP_286902.1 15800886 959026 1289061..1291484 1 NC_002655.2 tail component encoded by cryptic prophage CP-933M; partial 1291484 959026 Z1380 Escherichia coli O157:H7 str. EDL933 tail component encoded by cryptic prophage CP-933M; partial NP_286902.1 1289061 D 155864 CDS NP_286903.1 15800887 959028 1291552..1292151 1 NC_002655.2 outer membrane protein Lom encoded by cryptic prophage CP-933M 1292151 959028 Z1381 Escherichia coli O157:H7 str. EDL933 outer membrane protein Lom encoded by cryptic prophage CP-933M NP_286903.1 1291552 D 155864 CDS NP_286904.1 15800888 959029 1292210..1293337 1 NC_002655.2 tail component encoded by cryptic prophage CP-933M; partial 1293337 959029 Z1382 Escherichia coli O157:H7 str. EDL933 tail component encoded by cryptic prophage CP-933M; partial NP_286904.1 1292210 D 155864 CDS NP_286905.1 15800889 959030 1293413..1293802 1 NC_002655.2 hypothetical protein 1293802 959030 Z1383 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286905.1 1293413 D 155864 CDS NP_286906.1 15800890 959031 complement(1293927..1294679) 1 NC_002655.2 hypothetical protein 1294679 959031 Z1385 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286906.1 1293927 R 155864 CDS NP_286907.1 15800891 959032 1295011..1295127 1 NC_002655.2 No significant matches; hypothetical protein 1295127 959032 Z1386 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286907.1 1295011 D 155864 CDS NP_286908.1 15800892 959033 complement(1295276..1295458) 1 NC_002655.2 hypothetical protein 1295458 959033 Z1387 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286908.1 1295276 R 155864 CDS NP_286909.1 15800893 959035 1296076..1297194 1 NC_002655.2 hydrogenase-1 small subunit 1297194 hyaA 959035 hyaA Escherichia coli O157:H7 str. EDL933 hydrogenase-1 small subunit NP_286909.1 1296076 D 155864 CDS NP_286910.1 15800894 959036 1297191..1298984 1 NC_002655.2 involved in hydrogen cycling during fermentative growth; hydrogenase 1 large subunit 1298984 hyaB 959036 hyaB Escherichia coli O157:H7 str. EDL933 hydrogenase 1 large subunit NP_286910.1 1297191 D 155864 CDS NP_286911.1 15800895 959037 1299003..1299710 1 NC_002655.2 hydrogenase 1 b-type cytochrome subunit 1299710 hyaC 959037 hyaC Escherichia coli O157:H7 str. EDL933 hydrogenase 1 b-type cytochrome subunit NP_286911.1 1299003 D 155864 CDS NP_286912.1 15800896 959038 1299707..1300294 1 NC_002655.2 HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1); hydrogenase 1 maturation protease 1300294 hyaD 959038 hyaD Escherichia coli O157:H7 str. EDL933 hydrogenase 1 maturation protease NP_286912.1 1299707 D 155864 CDS NP_286913.1 15800897 959040 1300291..1300689 1 NC_002655.2 involved in processing hydrogenases HyaA and HyaB; hydrogenase-1 operon protein HyaE 1300689 hyaE 959040 hyaE Escherichia coli O157:H7 str. EDL933 hydrogenase-1 operon protein HyaE NP_286913.1 1300291 D 155864 CDS NP_286914.1 15800898 959041 1300686..1301543 1 NC_002655.2 hydrogenase-1 operon protein HyaF 1301543 hyaF 959041 hyaF Escherichia coli O157:H7 str. EDL933 hydrogenase-1 operon protein HyaF NP_286914.1 1300686 D 155864 CDS NP_286915.1 15800899 959042 1301677..1303221 1 NC_002655.2 third cytochrome oxidase, subunit I 1303221 appC 959042 appC Escherichia coli O157:H7 str. EDL933 third cytochrome oxidase, subunit I NP_286915.1 1301677 D 155864 CDS NP_286916.1 15800900 959043 1303233..1304369 1 NC_002655.2 third cytochrome oxidase, subunit II 1304369 appB 959043 appB Escherichia coli O157:H7 str. EDL933 third cytochrome oxidase, subunit II NP_286916.1 1303233 D 155864 CDS NP_286917.1 15800901 959044 1304524..1305858 1 NC_002655.2 phosphoanhydride phosphorylase 1305858 appA 959044 appA Escherichia coli O157:H7 str. EDL933 phosphoanhydride phosphorylase NP_286917.1 1304524 D 155864 CDS NP_286918.1 15800902 959045 complement(1305978..1308158) 1 NC_002655.2 cryptic autophosphorylating protein tyrosine kinase Etk 1308158 yccC 959045 yccC Escherichia coli O157:H7 str. EDL933 cryptic autophosphorylating protein tyrosine kinase Etk NP_286918.1 1305978 R 155864 CDS NP_286919.2 161367623 959046 complement(1308178..1308624) 1 NC_002655.2 Etk and Etp are a tyrosine kinase-tyrosine phosphatase pair, etp dephosphorylates etk; phosphotyrosine-protein phosphatase 1308624 etp 959046 etp Escherichia coli O157:H7 str. EDL933 phosphotyrosine-protein phosphatase NP_286919.2 1308178 R 155864 CDS NP_286920.1 15800904 959047 complement(1308612..1309751) 1 NC_002655.2 function in exopolysaccharide production 1309751 yccZ 959047 yccZ Escherichia coli O157:H7 str. EDL933 function in exopolysaccharide production NP_286920.1 1308612 R 155864 CDS NP_286921.1 15800905 959048 complement(1309797..1311893) 1 NC_002655.2 hypothetical protein 1311893 ymcA 959048 ymcA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286921.1 1309797 R 155864 CDS NP_286922.1 15800906 959049 complement(1311893..1312639) 1 NC_002655.2 hypothetical protein 1312639 ymcB 959049 ymcB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286922.1 1311893 R 155864 CDS NP_286923.1 15800907 959050 complement(1312636..1313280) 1 NC_002655.2 regulator 1313280 ymcC 959050 ymcC Escherichia coli O157:H7 str. EDL933 regulator NP_286923.1 1312636 R 155864 CDS NP_286924.1 15800908 959051 complement(1313387..1313710) 1 NC_002655.2 hypothetical protein 1313710 ymcD 959051 ymcD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286924.1 1313387 R 155864 CDS NP_286925.1 15800909 959052 complement(1314134..1314346) 1 NC_002655.2 cold shock-like protein 1314346 cspH 959052 cspH Escherichia coli O157:H7 str. EDL933 cold shock-like protein NP_286925.1 1314134 R 155864 CDS NP_286926.1 15800910 959053 1314632..1314844 1 NC_002655.2 cold shock protein CspG 1314844 cspG 959053 cspG Escherichia coli O157:H7 str. EDL933 cold shock protein CspG NP_286926.1 1314632 D 155864 CDS NP_286927.1 15800911 959054 1315018..1315248 1 NC_002655.2 cold shock gene 1315248 sfa 959054 sfa Escherichia coli O157:H7 str. EDL933 cold shock gene NP_286927.1 1315018 D 155864 CDS NP_286928.1 15800912 959055 complement(1315459..1316532) 1 NC_002655.2 hypothetical protein 1316532 yccM 959055 yccM Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286928.1 1315459 R 155864 CDS NP_286929.2 161367622 959056 complement(1316604..1319348) 1 NC_002655.2 Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide; hybrid sensory histidine kinase TorS 1319348 torS 959056 torS Escherichia coli O157:H7 str. EDL933 hybrid sensory histidine kinase TorS NP_286929.2 1316604 R 155864 CDS NP_286930.1 15800914 959057 1319431..1320459 1 NC_002655.2 periplasmic sensory protein associated with the TorRS two-component regulatory system; TMAO reductase system periplasmic protein TorT 1320459 torT 959057 torT Escherichia coli O157:H7 str. EDL933 TMAO reductase system periplasmic protein TorT NP_286930.1 1319431 D 155864 CDS NP_286931.1 15800915 959058 complement(1320432..1321124) 1 NC_002655.2 response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes; DNA-binding transcriptional regulator TorR 1321124 torR 959058 torR Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator TorR NP_286931.1 1320432 R 155864 CDS NP_286932.1 15800916 959059 1321254..1322426 1 NC_002655.2 trimethylamine N-oxide reductase 1322426 torC 959059 torC Escherichia coli O157:H7 str. EDL933 trimethylamine N-oxide reductase NP_286932.1 1321254 D 155864 CDS NP_286933.1 15800917 959060 1322426..1324972 1 NC_002655.2 trimethylamine N-oxide reductase subunit 1324972 torA 959060 torA Escherichia coli O157:H7 str. EDL933 trimethylamine N-oxide reductase subunit NP_286933.1 1322426 D 155864 CDS NP_286934.1 15800918 959061 1324969..1325568 1 NC_002655.2 TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; chaperone protein TorD 1325568 torD 959061 torD Escherichia coli O157:H7 str. EDL933 chaperone protein TorD NP_286934.1 1324969 D 155864 CDS NP_286935.1 15800919 959062 complement(1325722..1326027) 1 NC_002655.2 with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA; chaperone-modulator protein CbpM 1326027 yccD 959062 yccD Escherichia coli O157:H7 str. EDL933 chaperone-modulator protein CbpM NP_286935.1 1325722 R 155864 CDS NP_286936.1 15800920 959063 complement(1326027..1326947) 1 NC_002655.2 functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock; curved DNA-binding protein CbpA 1326947 cbpA 959063 cbpA Escherichia coli O157:H7 str. EDL933 curved DNA-binding protein CbpA NP_286936.1 1326027 R 155864 CDS NP_286937.1 15800921 959064 1327207..1328106 1 NC_002655.2 hypothetical protein 1328106 959064 Z1419 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286937.1 1327207 D 155864 CDS NP_286938.1 15800922 959065 1328114..1328464 1 NC_002655.2 hypothetical protein 1328464 959065 Z1420 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286938.1 1328114 D 155864 CDS NP_286939.1 15800923 959066 1328755..1329996 1 NC_002655.2 glucose-1-phosphatase/inositol phosphatase 1329996 agp 959066 agp Escherichia coli O157:H7 str. EDL933 glucose-1-phosphatase/inositol phosphatase NP_286939.1 1328755 D 155864 CDS NP_286940.1 15800924 959067 complement(1330034..1330261) 1 NC_002655.2 hypothetical protein 1330261 yccJ 959067 yccJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286940.1 1330034 R 155864 CDS NP_286941.1 15800925 959068 complement(1330282..1330827) 1 NC_002655.2 stationary phase that binds TrpR repressor; TrpR binding protein WrbA 1330827 wrbA 959068 wrbA Escherichia coli O157:H7 str. EDL933 TrpR binding protein WrbA NP_286941.1 1330282 R 155864 CDS NP_286942.1 15800926 959069 complement(1330857..1332191) 1 NC_002655.2 integrase for bacteriophage BP-933W 1332191 intW 959069 intW Escherichia coli O157:H7 str. EDL933 integrase for bacteriophage BP-933W NP_286942.1 1330857 R 155864 CDS NP_286943.1 15800927 959070 complement(1332220..1332519) 1 NC_002655.2 excisionase 1332519 xisW 959070 xisW Escherichia coli O157:H7 str. EDL933 excisionase NP_286943.1 1332220 R 155864 CDS NP_286944.1 15800928 959071 complement(1332590..1332901) 1 NC_002655.2 hypothetical protein 1332901 959071 Z1426 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286944.1 1332590 R 155864 CDS NP_286945.1 15800929 959072 complement(1332961..1333326) 1 NC_002655.2 No significant matches; hypothetical protein 1333326 959072 Z1428 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286945.1 1332961 R 155864 CDS NP_286946.1 15800930 959073 complement(1333238..1333861) 1 NC_002655.2 hypothetical protein 1333861 959073 Z1429 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286946.1 1333238 R 155864 CDS NP_286947.1 15800931 959074 complement(1333865..1334152) 1 NC_002655.2 hypothetical protein 1334152 959074 Z1430 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286947.1 1333865 R 155864 CDS NP_286948.1 15800932 959075 1334191..1334487 1 NC_002655.2 No significant matches; hypothetical protein 1334487 959075 Z1431 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286948.1 1334191 D 155864 CDS NP_286949.1 15800933 959076 complement(1334931..1335704) 1 NC_002655.2 hypothetical protein 1335704 959076 Z1432 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286949.1 1334931 R 155864 CDS NP_286950.1 15800934 959077 complement(1336021..1336302) 1 NC_002655.2 hypothetical protein 1336302 959077 Z1433 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286950.1 1336021 R 155864 CDS NP_286951.1 15800935 959078 complement(1336313..1336504) 1 NC_002655.2 hypothetical protein 1336504 959078 Z1434 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286951.1 1336313 R 155864 CDS NP_286952.1 15800936 959079 complement(1336659..1337336) 1 NC_002655.2 exonuclease of bacteriophage BP-933W 1337336 exoW 959079 exoW Escherichia coli O157:H7 str. EDL933 exonuclease of bacteriophage BP-933W NP_286952.1 1336659 R 155864 CDS NP_286953.1 15800937 959080 complement(1337333..1338118) 1 NC_002655.2 Bet recombination protein of bacteriophage BP-933W 1338118 betW 959080 betW Escherichia coli O157:H7 str. EDL933 Bet recombination protein of bacteriophage BP-933W NP_286953.1 1337333 R 155864 CDS NP_286954.1 15800938 959081 complement(1338124..1338420) 1 NC_002655.2 host-nuclease inhibitor protein Gam of bacteriphage BP-933W 1338420 gamW 959081 gamW Escherichia coli O157:H7 str. EDL933 host-nuclease inhibitor protein Gam of bacteriphage BP-933W NP_286954.1 1338124 R 155864 CDS NP_286955.1 15800939 959082 complement(1338496..1338765) 1 NC_002655.2 Kil protein of bacteriphage BP-933W 1338765 kilW 959082 kilW Escherichia coli O157:H7 str. EDL933 Kil protein of bacteriphage BP-933W NP_286955.1 1338496 R 155864 CDS NP_286956.1 15800940 959083 complement(1338845..1339213) 1 NC_002655.2 single-stranded DNA binding protein 1339213 ssbW 959083 ssbW Escherichia coli O157:H7 str. EDL933 single-stranded DNA binding protein NP_286956.1 1338845 R 155864 CDS NP_286957.1 15800941 959084 complement(1339364..1339834) 1 NC_002655.2 hypothetical protein 1339834 959084 Z1441 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286957.1 1339364 R 155864 CDS NP_286958.1 15800942 959085 complement(1339893..1340276) 1 NC_002655.2 antitermination protein N of bacteriophage BP-933W 1340276 959085 Z1442 Escherichia coli O157:H7 str. EDL933 antitermination protein N of bacteriophage BP-933W NP_286958.1 1339893 R 155864 CDS NP_286959.1 15800943 959086 complement(1340765..1340929) 1 NC_002655.2 hypothetical protein 1340929 959086 Z1443 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286959.1 1340765 R 155864 CDS NP_286960.1 15800944 959087 complement(1340932..1341978) 1 NC_002655.2 serine/threonine kinase encoded by bacteriophage BP-933W 1341978 959087 Z1444 Escherichia coli O157:H7 str. EDL933 serine/threonine kinase encoded by bacteriophage BP-933W NP_286960.1 1340932 R 155864 CDS NP_286961.1 15800945 959088 complement(1341972..1342433) 1 NC_002655.2 hypothetical protein 1342433 959088 Z1445 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286961.1 1341972 R 155864 CDS NP_286962.1 15800946 959089 complement(1342501..1342842) 1 NC_002655.2 hypothetical protein 1342842 959089 Z1446 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286962.1 1342501 R 155864 CDS NP_286963.1 15800947 959090 complement(1342903..1343610) 1 NC_002655.2 repressor protein CI of bacteriophage BP-933W 1343610 959090 Z1447 Escherichia coli O157:H7 str. EDL933 repressor protein CI of bacteriophage BP-933W NP_286963.1 1342903 R 155864 CDS NP_286964.1 15800948 959091 1343689..1343916 1 NC_002655.2 regulatory protein Cro of bacteriophage BP-933W 1343916 959091 Z1448 Escherichia coli O157:H7 str. EDL933 regulatory protein Cro of bacteriophage BP-933W NP_286964.1 1343689 D 155864 CDS NP_286965.1 15800949 959092 1344055..1344351 1 NC_002655.2 regulatory protein CII of bacteriophage BP-933W 1344351 959092 Z1449 Escherichia coli O157:H7 str. EDL933 regulatory protein CII of bacteriophage BP-933W NP_286965.1 1344055 D 155864 CDS NP_286966.1 15800950 959093 1344384..1345322 1 NC_002655.2 replication protein O of bacteriophage BP-933W 1345322 959093 Z1450 Escherichia coli O157:H7 str. EDL933 replication protein O of bacteriophage BP-933W NP_286966.1 1344384 D 155864 CDS NP_286967.1 15800951 959094 1345319..1346020 1 NC_002655.2 replication protein P of bacteriophage BP-933W 1346020 959094 Z1451 Escherichia coli O157:H7 str. EDL933 replication protein P of bacteriophage BP-933W NP_286967.1 1345319 D 155864 CDS NP_286968.1 15800952 959095 1346378..1346656 1 NC_002655.2 hypothetical protein 1346656 959095 Z1452 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286968.1 1346378 D 155864 CDS NP_286969.1 15800953 959096 1347208..1347654 1 NC_002655.2 hypothetical protein 1347654 959096 Z1453 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286969.1 1347208 D 155864 CDS NP_286970.1 15800954 959097 1347651..1348178 1 NC_002655.2 DNA N-6-adenine-methyltransferase of bacteriophage BP-933W 1348178 959097 Z1454 Escherichia coli O157:H7 str. EDL933 DNA N-6-adenine-methyltransferase of bacteriophage BP-933W NP_286970.1 1347651 D 155864 CDS NP_286971.1 15800955 959098 1348366..1349409 1 NC_002655.2 hypothetical protein 1349409 959098 Z1456 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286971.1 1348366 D 155864 CDS NP_286972.1 15800956 959099 1349555..1350283 1 NC_002655.2 DNA-binding protein Roi of bacteriophage BP-933W 1350283 959099 Z1457 Escherichia coli O157:H7 str. EDL933 DNA-binding protein Roi of bacteriophage BP-933W NP_286972.1 1349555 D 155864 CDS NP_286973.1 15800957 959100 1350283..1350888 1 NC_002655.2 hypothetical protein 1350888 959100 Z1458 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286973.1 1350283 D 155864 CDS NP_286974.1 15800958 959101 1351072..1351506 1 NC_002655.2 antitermination protein Q of bacteriophage BP-933W 1351506 959101 Z1459 Escherichia coli O157:H7 str. EDL933 antitermination protein Q of bacteriophage BP-933W NP_286974.1 1351072 D 155864 CDS NP_286975.1 15800959 959102 1351809..1351907 1 NC_002655.2 hypothetical protein 1351907 959102 Z1460 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286975.1 1351809 D 155864 CDS NP_286976.1 15800960 959106 1352290..1353249 1 NC_002655.2 shiga-like toxin II A subunit encoded by bacteriophage BP-933W 1353249 stx2A 959106 stx2A Escherichia coli O157:H7 str. EDL933 shiga-like toxin II A subunit encoded by bacteriophage BP-933W NP_286976.1 1352290 D 155864 CDS NP_286977.1 15800961 959107 1353261..1353530 1 NC_002655.2 shiga-like toxin II B subunit encoded by bacteriophage BP-933W 1353530 stx2B 959107 stx2B Escherichia coli O157:H7 str. EDL933 shiga-like toxin II B subunit encoded by bacteriophage BP-933W NP_286977.1 1353261 D 155864 CDS NP_286978.1 15800962 959108 1354017..1355954 1 NC_002655.2 hypothetical protein 1355954 959108 Z1466 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286978.1 1354017 D 155864 CDS NP_286979.1 15800963 959109 1356135..1356581 1 NC_002655.2 hypothetical protein 1356581 959109 Z1467 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286979.1 1356135 D 155864 CDS NP_286980.1 15800964 959110 1356658..1356873 1 NC_002655.2 lysis protein S of bacteriophage BP-933W 1356873 959110 Z1468 Escherichia coli O157:H7 str. EDL933 lysis protein S of bacteriophage BP-933W NP_286980.1 1356658 D 155864 CDS NP_286981.1 15800965 959111 1356878..1357411 1 NC_002655.2 lysozyme protein R of bacteriophage BP-933W 1357411 959111 Z1469 Escherichia coli O157:H7 str. EDL933 lysozyme protein R of bacteriophage BP-933W NP_286981.1 1356878 D 155864 CDS NP_286982.1 15800966 959112 1357682..1358251 1 NC_002655.2 No significant matches; antirepressor protein Ant of bacteriophage BP-933W 1358251 959112 Z1471 Escherichia coli O157:H7 str. EDL933 antirepressor protein Ant of bacteriophage BP-933W NP_286982.1 1357682 D 155864 CDS NP_286983.1 15800967 959113 1358405..1358869 1 NC_002655.2 endopeptidase Rz of bacteriophage BP-933W 1358869 959113 Z1473 Escherichia coli O157:H7 str. EDL933 endopeptidase Rz of bacteriophage BP-933W NP_286983.1 1358405 D 155864 CDS NP_286984.1 15800968 959114 complement(1358901..1359194) 1 NC_002655.2 Bor protein of bacteriophage BP-933W 1359194 borW 959114 borW Escherichia coli O157:H7 str. EDL933 Bor protein of bacteriophage BP-933W NP_286984.1 1358901 R 155864 CDS NP_286985.1 15800969 959115 1359603..1360409 1 NC_002655.2 terminase small subunit of bacteriophage BP-933W 1360409 959115 Z1475 Escherichia coli O157:H7 str. EDL933 terminase small subunit of bacteriophage BP-933W NP_286985.1 1359603 D 155864 CDS NP_286986.1 15800970 959116 1360390..1362096 1 NC_002655.2 terminase large subunit of bacteriophage BP-933W 1362096 959116 Z1476 Escherichia coli O157:H7 str. EDL933 terminase large subunit of bacteriophage BP-933W NP_286986.1 1360390 D 155864 CDS NP_286987.1 15800971 959117 1362096..1364240 1 NC_002655.2 portal protein of bacteriophage BP-933W 1364240 959117 Z1477 Escherichia coli O157:H7 str. EDL933 portal protein of bacteriophage BP-933W NP_286987.1 1362096 D 155864 CDS NP_286988.1 15800972 959118 1364398..1365405 1 NC_002655.2 hypothetical protein 1365405 959118 Z1478 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286988.1 1364398 D 155864 CDS NP_286989.1 15800973 959119 1365429..1366643 1 NC_002655.2 hypothetical protein 1366643 959119 Z1479 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286989.1 1365429 D 155864 CDS NP_286990.1 15800974 959120 1366699..1367088 1 NC_002655.2 hypothetical protein 1367088 959120 Z1480 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286990.1 1366699 D 155864 CDS NP_286991.1 15800975 959121 1367138..1367599 1 NC_002655.2 hypothetical protein 1367599 959121 Z1481 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286991.1 1367138 D 155864 CDS NP_286992.1 15800976 959122 1368146..1368796 1 NC_002655.2 hypothetical protein 1368796 959122 Z1482 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286992.1 1368146 D 155864 CDS NP_286993.1 15800977 959123 1368793..1370730 1 NC_002655.2 tail fiber protein of bacteriophage BP-933W 1370730 959123 Z1483 Escherichia coli O157:H7 str. EDL933 tail fiber protein of bacteriophage BP-933W NP_286993.1 1368793 D 155864 CDS NP_286994.1 15800978 959124 1370693..1371001 1 NC_002655.2 tail fiber protein of bacteriophage BP-933W 1371001 959124 Z1484 Escherichia coli O157:H7 str. EDL933 tail fiber protein of bacteriophage BP-933W NP_286994.1 1370693 D 155864 CDS NP_286995.1 15800979 959125 1371048..1371329 1 NC_002655.2 hypothetical protein 1371329 959125 Z1485 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286995.1 1371048 D 155864 CDS NP_286996.1 15800980 959126 1371546..1373249 1 NC_002655.2 hypothetical protein 1373249 959126 Z1486 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286996.1 1371546 D 155864 CDS NP_286997.1 15800981 959127 1373291..1374514 1 NC_002655.2 hypothetical protein 1374514 959127 Z1487 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286997.1 1373291 D 155864 CDS NP_286998.1 15800982 959128 1374813..1375430 1 NC_002655.2 hypothetical protein 1375430 959128 Z1488 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_286998.1 1374813 D 155864 CDS NP_286999.1 15800983 959129 1375521..1376255 1 NC_002655.2 outer membrane protein Lom of bacteriophage BP-933W 1376255 lomW 959129 lomW Escherichia coli O157:H7 str. EDL933 outer membrane protein Lom of bacteriophage BP-933W NP_286999.1 1375521 D 155864 CDS NP_287000.1 15800984 959130 1376685..1377086 1 NC_002655.2 hypothetical protein 1377086 959130 Z1490 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287000.1 1376685 D 155864 CDS NP_287001.1 15800985 959131 1377180..1377836 1 NC_002655.2 hypothetical protein 1377836 959131 Z1491 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287001.1 1377180 D 155864 CDS NP_287002.1 15800986 959132 1377839..1378285 1 NC_002655.2 hypothetical protein 1378285 959132 Z1492 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287002.1 1377839 D 155864 CDS NP_287003.1 15800987 959133 1378295..1378546 1 NC_002655.2 hypothetical protein 1378546 959133 Z1493 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287003.1 1378295 D 155864 CDS NP_287004.1 15800988 959134 1378557..1379822 1 NC_002655.2 hypothetical protein 1379822 959134 Z1494 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287004.1 1378557 D 155864 CDS NP_287005.1 15800989 959135 1379853..1388273 1 NC_002655.2 hypothetical protein 1388273 959135 Z1495 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287005.1 1379853 D 155864 CDS NP_287006.1 15800990 959136 complement(1388824..1389168) 1 NC_002655.2 hypothetical protein 1389168 959136 Z1498 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287006.1 1388824 R 155864 CDS NP_287007.1 15800991 959137 complement(1389734..1390129) 1 NC_002655.2 hypothetical protein 1390129 959137 Z1500 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287007.1 1389734 R 155864 CDS NP_287008.1 15800992 959139 complement(1390129..1391028) 1 NC_002655.2 hypothetical protein 1391028 959139 Z1501 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287008.1 1390129 R 155864 CDS NP_287009.1 15800993 959140 complement(1391294..1391923) 1 NC_002655.2 hypothetical protein 1391923 959140 Z1503 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287009.1 1391294 R 155864 CDS NP_287011.1 15800995 959142 complement(1393103..1394497) 1 NC_002655.2 transporter 1394497 ycdG 959142 ycdG Escherichia coli O157:H7 str. EDL933 transporter NP_287011.1 1393103 R 155864 CDS NP_287012.1 15800996 959143 complement(1394452..1394910) 1 NC_002655.2 4-hydroxyphenylacetate 3-monooxygenase 1394910 959143 Z1506 Escherichia coli O157:H7 str. EDL933 4-hydroxyphenylacetate 3-monooxygenase NP_287012.1 1394452 R 155864 CDS NP_287013.1 15800997 959144 complement(1394957..1395547) 1 NC_002655.2 hypothetical protein 1395547 959144 Z1507 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287013.1 1394957 R 155864 CDS NP_287014.1 15800998 959145 complement(1395557..1396357) 1 NC_002655.2 acetyltransferase 1396357 959145 Z1508 Escherichia coli O157:H7 str. EDL933 acetyltransferase NP_287014.1 1395557 R 155864 CDS NP_287015.1 15800999 959146 complement(1396365..1396751) 1 NC_002655.2 hypothetical protein 1396751 959146 Z1509 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287015.1 1396365 R 155864 CDS NP_287016.1 15801000 959147 complement(1396763..1397497) 1 NC_002655.2 synthetase 1397497 959147 Z1510 Escherichia coli O157:H7 str. EDL933 synthetase NP_287016.1 1396763 R 155864 CDS NP_287017.1 15801001 959148 complement(1397455..1398603) 1 NC_002655.2 hypothetical protein 1398603 959148 Z1511 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287017.1 1397455 R 155864 CDS NP_287018.1 15801002 959149 1398834..1399472 1 NC_002655.2 tet operon regulator 1399472 ycdC 959149 ycdC Escherichia coli O157:H7 str. EDL933 tet operon regulator NP_287018.1 1398834 D 155864 CDS NP_287019.1 15801003 959150 complement(1399512..1403474) 1 NC_002655.2 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein; trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 1403474 putA 959150 putA Escherichia coli O157:H7 str. EDL933 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase NP_287019.1 1399512 R 155864 CDS NP_287020.1 15801004 959151 1403897..1405405 1 NC_002655.2 major sodium/proline symporter 1405405 putP 959151 putP Escherichia coli O157:H7 str. EDL933 major sodium/proline symporter NP_287020.1 1403897 D 155864 CDS NP_287021.1 15801005 959152 complement(1405554..1406897) 1 NC_002655.2 No significant matches; hypothetical protein 1406897 959152 Z1516 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287021.1 1405554 R 155864 CDS NP_287022.1 15801006 959153 1407460..1407606 1 NC_002655.2 No significant matches; hypothetical protein 1407606 959153 Z1517 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287022.1 1407460 D 155864 CDS NP_287023.1 15801007 959154 complement(1407897..1408043) 1 NC_002655.2 No significant matches; hypothetical protein 1408043 959154 Z1518 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287023.1 1407897 R 155864 CDS NP_287024.1 15801008 959155 1408070..1408909 1 NC_002655.2 hypothetical protein 1408909 959155 Z1519 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287024.1 1408070 D 155864 CDS NP_287025.1 15801009 959156 1408967..1410094 1 NC_002655.2 hypothetical protein 1410094 ycdO 959156 ycdO Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287025.1 1408967 D 155864 CDS NP_287026.1 15801010 959157 1410100..1411371 1 NC_002655.2 hypothetical protein 1411371 ycdB 959157 ycdB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287026.1 1410100 D 155864 CDS NP_287027.1 15801011 959158 1411715..1412779 1 NC_002655.2 hypothetical protein 1412779 phoH 959158 phoH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287027.1 1411715 D 155864 CDS NP_287028.1 15801012 959159 complement(1412829..1413242) 1 NC_002655.2 in Yersinia this gene is involved in biofilm formation and hemin adsorption; in Escherichia coli it is involved in PGA biosynthesis and export; PGA biosynthesis protein 1413242 pgaD 959159 pgaD Escherichia coli O157:H7 str. EDL933 PGA biosynthesis protein NP_287028.1 1412829 R 155864 CDS NP_287029.1 15801013 959160 complement(1413244..1414569) 1 NC_002655.2 predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein; N-glycosyltransferase 1414569 ycdQ 959160 ycdQ Escherichia coli O157:H7 str. EDL933 N-glycosyltransferase NP_287029.1 1413244 R 155864 CDS NP_287030.1 15801014 959161 complement(1414562..1416580) 1 NC_002655.2 in Yersinia this protein is involved in biofilm formation and hemin adsorption; related protein PgaB in Escherichia coli is an outer membrane N-deacetylase involved in poly-beta-1,6-N-acetyl-D-glucosamine (PGA) export; outer membrane N-deacetylase 1416580 pgaB 959161 pgaB Escherichia coli O157:H7 str. EDL933 outer membrane N-deacetylase NP_287030.1 1414562 R 155864 CDS NP_287031.1 15801015 959162 complement(1416589..1419012) 1 NC_002655.2 outer membrane protein essential for the synthesis of poly-beta-1,6-N-acetyl-D-glucosamine (PGA); adhesin required for biofilm formation; PgaA (HmsH) seems to translocate and/or dock PGA to the cell surface; member of the hmsHFRS (ycdSRQP or pgaABCD in Escherichia coli) operon in Yersinia; outer membrane protein PgaA 1419012 pgaA 959162 pgaA Escherichia coli O157:H7 str. EDL933 outer membrane protein PgaA NP_287031.1 1416589 R 155864 CDS NP_287032.1 15801016 959163 1419599..1420957 1 NC_002655.2 hypothetical protein 1420957 ycdT 959163 ycdT Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287032.1 1419599 D 155864 CDS NP_287033.1 15801017 959164 1421055..1422665 1 NC_002655.2 hypothetical protein 1422665 959164 Z1528 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287033.1 1421055 D 155864 CDS NP_287034.1 15801018 959165 complement(1422767..1423258) 1 NC_002655.2 hypothetical protein 1423258 959165 Z1530 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287034.1 1422767 R 155864 CDS NP_287035.1 15801019 959166 complement(1423263..1424075) 1 NC_002655.2 hypothetical protein 1424075 959166 Z1531 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287035.1 1423263 R 155864 CDS NP_287036.1 15801020 959167 1424667..1424747 1 NC_002655.2 No significant matches; hypothetical protein 1424747 959167 Z1532 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287036.1 1424667 D 155864 CDS NP_287037.1 15801021 959168 1424754..1425545 1 NC_002655.2 oxidoreductase 1425545 959168 Z1533 Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_287037.1 1424754 D 155864 CDS NP_287038.1 15801022 959169 complement(1425691..1426380) 1 NC_002655.2 chaperone 1426380 959169 Z1534 Escherichia coli O157:H7 str. EDL933 chaperone NP_287038.1 1425691 R 155864 CDS NP_287039.1 15801023 959170 complement(1426377..1427711) 1 NC_002655.2 hypothetical protein 1427711 959170 Z1535 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287039.1 1426377 R 155864 CDS NP_287040.1 15801024 959171 complement(1427727..1430249) 1 NC_002655.2 usher protein 1430249 959171 Z1536 Escherichia coli O157:H7 str. EDL933 usher protein NP_287040.1 1427727 R 155864 CDS NP_287041.1 15801025 959172 complement(1430302..1431024) 1 NC_002655.2 chaperone 1431024 959172 Z1537 Escherichia coli O157:H7 str. EDL933 chaperone NP_287041.1 1430302 R 155864 CDS NP_287042.1 15801026 959173 complement(1431089..1431649) 1 NC_002655.2 pilin subunit 1431649 959173 Z1538 Escherichia coli O157:H7 str. EDL933 pilin subunit NP_287042.1 1431089 R 155864 CDS NP_287043.1 15801027 959174 complement(1431692..1432315) 1 NC_002655.2 No significant matches; hypothetical protein 1432315 959174 Z1539 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287043.1 1431692 R 155864 CDS NP_287044.1 15801028 959175 complement(1432584..1432694) 1 NC_002655.2 No significant matches; hypothetical protein 1432694 959175 Z1540 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287044.1 1432584 R 155864 CDS NP_287045.1 15801029 959176 complement(1433156..1433275) 1 NC_002655.2 No significant matches; hypothetical protein 1433275 959176 Z1541 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287045.1 1433156 R 155864 CDS NP_287046.1 15801030 959177 1433706..1437518 1 NC_002655.2 ShlA/HecA/FhaA exofamily protein 1437518 959177 Z1542 Escherichia coli O157:H7 str. EDL933 ShlA/HecA/FhaA exofamily protein NP_287046.1 1433706 D 155864 CDS NP_287047.1 15801031 959178 1437607..1439226 1 NC_002655.2 ShlA/HecA/FhaA exofamily protein 1439226 959178 Z1543 Escherichia coli O157:H7 str. EDL933 ShlA/HecA/FhaA exofamily protein NP_287047.1 1437607 D 155864 CDS NP_287048.1 15801032 959179 1439242..1439610 1 NC_002655.2 ACP synthase 1439610 959179 Z1544 Escherichia coli O157:H7 str. EDL933 ACP synthase NP_287048.1 1439242 D 155864 CDS NP_287049.1 15801033 959180 1439630..1440385 1 NC_002655.2 fatty acyl chain reductase 1440385 959180 Z1545 Escherichia coli O157:H7 str. EDL933 fatty acyl chain reductase NP_287049.1 1439630 D 155864 CDS NP_287050.1 15801034 959181 1440389..1440937 1 NC_002655.2 fatty acyl chain dehydrase 1440937 959181 Z1546 Escherichia coli O157:H7 str. EDL933 fatty acyl chain dehydrase NP_287050.1 1440389 D 155864 CDS NP_287051.1 15801035 959182 1440959..1441240 1 NC_002655.2 acyl carrier protein 1441240 959182 Z1547 Escherichia coli O157:H7 str. EDL933 acyl carrier protein NP_287051.1 1440959 D 155864 CDS NP_287052.1 15801036 959183 1441276..1442436 1 NC_002655.2 glycine cleavage system protein T 1442436 959183 Z1548 Escherichia coli O157:H7 str. EDL933 glycine cleavage system protein T NP_287052.1 1441276 D 155864 CDS NP_287053.1 15801037 959185 1442510..1445068 1 NC_002655.2 beta-ketoacyl-[acyl carrier protein] synthase 1445068 959185 Z1549 Escherichia coli O157:H7 str. EDL933 beta-ketoacyl-[acyl carrier protein] synthase NP_287053.1 1442510 D 155864 CDS NP_287054.1 15801038 959186 1445073..1446296 1 NC_002655.2 hypothetical protein 1446296 959186 Z1550 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287054.1 1445073 D 155864 CDS NP_287055.1 15801039 959187 1446293..1447246 1 NC_002655.2 No significant matches; hypothetical protein 1447246 959187 Z1551 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287055.1 1446293 D 155864 CDS NP_287056.1 15801040 959188 1447257..1447964 1 NC_002655.2 hypothetical protein 1447964 959188 Z1552 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287056.1 1447257 D 155864 CDS NP_287057.1 15801041 959189 1447948..1448604 1 NC_002655.2 No significant matches; hypothetical protein 1448604 959189 Z1553 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287057.1 1447948 D 155864 CDS NP_287058.1 15801042 959190 1448605..1449915 1 NC_002655.2 hypothetical protein 1449915 959190 Z1554 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287058.1 1448605 D 155864 CDS NP_287059.1 15801043 959191 1449924..1450712 1 NC_002655.2 No significant matches; hypothetical protein 1450712 959191 Z1555 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287059.1 1449924 D 155864 CDS NP_287060.1 15801044 959192 1450709..1452097 1 NC_002655.2 No significant matches; hypothetical protein 1452097 959192 Z1556 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287060.1 1450709 D 155864 CDS NP_287061.1 15801045 959193 1452729..1453052 1 NC_002655.2 hypothetical protein 1453052 959193 Z1557 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287061.1 1452729 D 155864 CDS NP_287062.1 15801046 959194 1453049..1454035 1 NC_002655.2 hypothetical protein 1454035 ycdU 959194 ycdU Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287062.1 1453049 D 155864 CDS NP_287063.1 15801047 959195 1454402..1455604 1 NC_002655.2 P4 family integrase 1455604 959195 Z1559 Escherichia coli O157:H7 str. EDL933 P4 family integrase NP_287063.1 1454402 D 155864 CDS NP_287064.1 15801048 959196 complement(1455791..1457608) 1 NC_002655.2 No significant matches; hypothetical protein 1457608 959196 Z1560 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287064.1 1455791 R 155864 CDS NP_287065.1 15801049 959197 1457976..1458077 1 NC_002655.2 hypothetical protein 1458077 959197 Z1561 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287065.1 1457976 D 155864 CDS NP_287066.1 15801050 959198 1458104..1458541 1 NC_002655.2 hypothetical protein 1458541 959198 Z1562 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287066.1 1458104 D 155864 CDS NP_287067.1 15801051 959199 1458720..1459016 1 NC_002655.2 prophage regulatory protein 1459016 959199 Z1563 Escherichia coli O157:H7 str. EDL933 prophage regulatory protein NP_287067.1 1458720 D 155864 CDS NP_287068.1 15801052 959200 1459243..1459440 1 NC_002655.2 hypothetical protein 1459440 959200 Z1564 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287068.1 1459243 D 155864 CDS NP_287069.1 15801053 959201 1459641..1461044 1 NC_002655.2 hypothetical protein 1461044 959201 Z1565 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287069.1 1459641 D 155864 CDS NP_287071.1 15801055 959205 1461865..1462428 1 NC_002655.2 No significant matches; hypothetical protein 1462428 959205 Z1567 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287071.1 1461865 D 155864 CDS NP_287072.1 15801056 959206 1462559..1464943 1 NC_002655.2 helicase 1464943 959206 Z1568 Escherichia coli O157:H7 str. EDL933 helicase NP_287072.1 1462559 D 155864 CDS NP_287073.1 15801057 959208 complement(1465105..1465374) 1 NC_002655.2 No significant matches; hypothetical protein 1465374 959208 Z1569 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287073.1 1465105 R 155864 CDS NP_287074.1 15801058 959209 complement(1465700..1467238) 1 NC_002655.2 hypothetical protein 1467238 959209 Z1570 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287074.1 1465700 R 155864 CDS NP_287075.1 15801059 959210 complement(1467288..1467635) 1 NC_002655.2 hypothetical protein 1467635 959210 Z1571 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287075.1 1467288 R 155864 CDS NP_287076.1 15801060 959212 complement(1468088..1468399) 1 NC_002655.2 transposase 1468399 959212 Z1572 Escherichia coli O157:H7 str. EDL933 transposase NP_287076.1 1468088 R 155864 CDS NP_287077.1 15801061 959213 1468539..1469357 1 NC_002655.2 hypothetical protein 1469357 959213 Z1573 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287077.1 1468539 D 155864 CDS NP_287078.1 15801062 959217 1469470..1470009 1 NC_002655.2 complement resistance protein 1470009 959217 Z1574 Escherichia coli O157:H7 str. EDL933 complement resistance protein NP_287078.1 1469470 D 155864 CDS NP_287079.1 15801063 959219 complement(1470057..1470350) 1 NC_002655.2 No significant matches; hypothetical protein 1470350 959219 Z1575 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287079.1 1470057 R 155864 CDS NP_287080.1 15801064 959222 complement(1470332..1470622) 1 NC_002655.2 No significant matches; hypothetical protein 1470622 959222 Z1576 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287080.1 1470332 R 155864 CDS NP_287082.1 15801066 959224 1471308..1471667 1 NC_002655.2 diacylglycerol kinase 1471667 959224 Z1578 Escherichia coli O157:H7 str. EDL933 diacylglycerol kinase NP_287082.1 1471308 D 155864 CDS NP_287083.1 15801067 959225 complement(1471760..1473379) 1 NC_002655.2 hypothetical protein 1473379 959225 Z1579 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287083.1 1471760 R 155864 CDS NP_287084.1 15801068 959226 complement(1473604..1473885) 1 NC_002655.2 No significant matches; hypothetical protein 1473885 959226 Z1580 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287084.1 1473604 R 155864 CDS NP_287085.1 15801069 959228 1474260..1474958 1 NC_002655.2 urease accessory protein D 1474958 ureD_2 959228 ureD_2 Escherichia coli O157:H7 str. EDL933 urease accessory protein D NP_287085.1 1474260 D 155864 CDS NP_287086.1 15801070 959229 1475049..1475351 1 NC_002655.2 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; urease subunit gamma 1475351 ureA 959229 ureA Escherichia coli O157:H7 str. EDL933 urease subunit gamma NP_287086.1 1475049 D 155864 CDS NP_287087.1 15801071 959230 1475360..1475680 1 NC_002655.2 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active; urease subunit beta 1475680 ureB 959230 ureB Escherichia coli O157:H7 str. EDL933 urease subunit beta NP_287087.1 1475360 D 155864 CDS NP_287088.1 15801072 959231 1475670..1477376 1 NC_002655.2 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 1477376 ureC 959231 ureC Escherichia coli O157:H7 str. EDL933 urease subunit alpha NP_287088.1 1475670 D 155864 CDS NP_287089.1 15801073 959232 1477386..1477850 1 NC_002655.2 involved in the assembly of the urease metallocenter; possible nickel donor; urease accessory protein UreE 1477850 ureE 959232 ureE Escherichia coli O157:H7 str. EDL933 urease accessory protein UreE NP_287089.1 1477386 D 155864 CDS NP_287090.1 15801074 959233 1477851..1478525 1 NC_002655.2 urease accessory protein F 1478525 ureF_2 959233 ureF_2 Escherichia coli O157:H7 str. EDL933 urease accessory protein F NP_287090.1 1477851 D 155864 CDS NP_287091.1 15801075 959235 1478537..1479154 1 NC_002655.2 urease accessory protein G 1479154 ureG_2 959235 ureG_2 Escherichia coli O157:H7 str. EDL933 urease accessory protein G NP_287091.1 1478537 D 155864 CDS NP_287092.1 15801076 959236 complement(1479202..1479333) 1 NC_002655.2 hypothetical protein 1479333 959236 Z1588 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287092.1 1479202 R 155864 CDS NP_287093.1 15801077 959237 complement(1479410..1479751) 1 NC_002655.2 hypothetical protein 1479751 959237 Z1589 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287093.1 1479410 R 155864 CDS NP_287094.1 15801078 959240 complement(1479813..1479941) 1 NC_002655.2 hypothetical protein 1479941 959240 Z1590 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287094.1 1479813 R 155864 CDS NP_287095.1 15801079 959241 1480366..1480629 1 NC_002655.2 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1480629 rpmE2 959241 rpmE2 Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L31 NP_287095.1 1480366 D 155864 CDS NP_287096.1 15801080 959242 1480931..1481071 1 NC_002655.2 No significant matches; hypothetical protein 1481071 959242 Z1592 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287096.1 1480931 D 155864 CDS NP_287097.1 15801081 959244 complement(1481486..1481638) 1 NC_002655.2 No significant matches; hypothetical protein 1481638 959244 Z1593 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287097.1 1481486 R 155864 CDS NP_287098.1 15801082 959245 complement(1481944..1482681) 1 NC_002655.2 No significant matches; hypothetical protein 1482681 959245 Z1594 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287098.1 1481944 R 155864 CDS NP_287099.1 15801083 959249 complement(1483064..1483204) 1 NC_002655.2 No significant matches; hypothetical protein 1483204 959249 Z1595 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287099.1 1483064 R 155864 CDS NP_287100.1 15801084 959253 complement(1483635..1483808) 1 NC_002655.2 No significant matches; hypothetical protein 1483808 959253 Z1596 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287100.1 1483635 R 155864 CDS NP_287101.1 15801085 959255 complement(1484148..1484633) 1 NC_002655.2 hypothetical protein 1484633 959255 Z1597 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287101.1 1484148 R 155864 CDS NP_287102.1 15801086 959256 1484953..1485378 1 NC_002655.2 hypothetical protein 1485378 959256 Z1598 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287102.1 1484953 D 155864 CDS NP_287103.1 15801087 959259 1485375..1485725 1 NC_002655.2 hypothetical protein 1485725 959259 Z1599 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287103.1 1485375 D 155864 CDS NP_287104.1 15801088 959261 1485756..1487369 1 NC_002655.2 hypothetical protein 1487369 959261 Z1600 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287104.1 1485756 D 155864 CDS NP_287105.1 15801089 959262 complement(1487373..1488230) 1 NC_002655.2 hypothetical protein 1488230 959262 Z1601 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287105.1 1487373 R 155864 CDS NP_287106.1 15801090 959265 complement(1488312..1488674) 1 NC_002655.2 hypothetical protein 1488674 959265 Z1602 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287106.1 1488312 R 155864 CDS NP_287107.1 15801091 959266 complement(1489230..1489697) 1 NC_002655.2 hypothetical protein 1489697 terW_2 959266 terW_2 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287107.1 1489230 R 155864 CDS NP_287108.1 15801092 959267 complement(1489715..1490923) 1 NC_002655.2 No significant matches; hypothetical protein 1490923 959267 Z1604 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287108.1 1489715 R 155864 CDS NP_287109.1 15801093 959268 complement(1490934..1491890) 1 NC_002655.2 hypothetical protein 1491890 959268 Z1605 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287109.1 1490934 R 155864 CDS NP_287110.1 15801094 959269 complement(1491890..1493005) 1 NC_002655.2 hypothetical protein 1493005 959269 Z1606 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287110.1 1491890 R 155864 CDS NP_287111.1 15801095 959270 complement(1492971..1493966) 1 NC_002655.2 hypothetical protein 1493966 959270 Z1607 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287111.1 1492971 R 155864 CDS NP_287112.1 15801096 959271 complement(1493737..1494879) 1 NC_002655.2 hypothetical protein 1494879 959271 Z1608 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287112.1 1493737 R 155864 CDS NP_287113.1 15801097 959272 complement(1494889..1495947) 1 NC_002655.2 hypothetical protein 1495947 959272 Z1609 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287113.1 1494889 R 155864 CDS NP_287114.1 15801098 959274 1496270..1496851 1 NC_002655.2 phage inhibition, colicin resistance and tellurite resistance protein 1496851 terZ_2 959274 terZ_2 Escherichia coli O157:H7 str. EDL933 phage inhibition, colicin resistance and tellurite resistance protein NP_287114.1 1496270 D 155864 CDS NP_287115.1 15801099 959276 1496851..1498008 1 NC_002655.2 phage inhibition, colicin resistance and tellurite resistance protein 1498008 terA_2 959276 terA_2 Escherichia coli O157:H7 str. EDL933 phage inhibition, colicin resistance and tellurite resistance protein NP_287115.1 1496851 D 155864 CDS NP_287116.1 15801100 959277 1498031..1498486 1 NC_002655.2 phage inhibition, colicin resistance and tellurite resistance protein 1498486 terB_2 959277 terB_2 Escherichia coli O157:H7 str. EDL933 phage inhibition, colicin resistance and tellurite resistance protein NP_287116.1 1498031 D 155864 CDS NP_287117.1 15801101 959278 1498509..1499549 1 NC_002655.2 phage inhibition, colicin resistance and tellurite resistance protein 1499549 terC_2 959278 terC_2 Escherichia coli O157:H7 str. EDL933 phage inhibition, colicin resistance and tellurite resistance protein NP_287117.1 1498509 D 155864 CDS NP_287118.1 15801102 959279 1499598..1500176 1 NC_002655.2 phage inhibition, colicin resistance and tellurite resistance protein 1500176 terD_2 959279 terD_2 Escherichia coli O157:H7 str. EDL933 phage inhibition, colicin resistance and tellurite resistance protein NP_287118.1 1499598 D 155864 CDS NP_287119.1 15801103 959280 1500245..1500820 1 NC_002655.2 phage inhibition, colicin resistance and tellurite resistance protein 1500820 terE_2 959280 terE_2 Escherichia coli O157:H7 str. EDL933 phage inhibition, colicin resistance and tellurite resistance protein NP_287119.1 1500245 D 155864 CDS NP_287120.1 15801104 959282 1501242..1501550 1 NC_002655.2 phage inhibition, colicin resistance and tellurite resistance protein 1501550 terF_2 959282 terF_2 Escherichia coli O157:H7 str. EDL933 phage inhibition, colicin resistance and tellurite resistance protein NP_287120.1 1501242 D 155864 CDS NP_287121.1 15801105 959284 complement(1502142..1504232) 1 NC_002655.2 IrgA-homologue adhesin (Iha); TonB-dependent; acts as a specific receptor of enterobactin; fur-regulated; urovirulence factor; bifunctional enterobactin receptor/adhesin protein 1504232 959284 Z1617 Escherichia coli O157:H7 str. EDL933 bifunctional enterobactin receptor/adhesin protein NP_287121.1 1502142 R 155864 CDS NP_287123.1 15801107 959287 complement(1504902..1505189) 1 NC_002655.2 No significant matches; hypothetical protein 1505189 959287 Z1619 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287123.1 1504902 R 155864 CDS NP_287124.1 15801108 959288 1505686..1505904 1 NC_002655.2 hypothetical protein 1505904 959288 Z1620 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287124.1 1505686 D 155864 CDS NP_287125.1 15801109 959290 complement(1506306..1506404) 1 NC_002655.2 No significant matches; hypothetical protein 1506404 959290 Z1621 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287125.1 1506306 R 155864 CDS NP_287126.1 15801110 959291 1506537..1506872 1 NC_002655.2 hypothetical protein 1506872 959291 Z1622 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287126.1 1506537 D 155864 CDS NP_287127.1 15801111 959292 1507389..1507523 1 NC_002655.2 No significant matches; hypothetical protein 1507523 959292 Z1623 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287127.1 1507389 D 155864 CDS NP_287128.1 15801112 959297 complement(1507653..1507847) 1 NC_002655.2 No significant matches; hypothetical protein 1507847 959297 Z1624 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287128.1 1507653 R 155864 CDS NP_287129.1 15801113 959299 1508168..1508440 1 NC_002655.2 No significant matches; hypothetical protein 1508440 959299 Z1625 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287129.1 1508168 D 155864 CDS NP_287130.1 15801114 959300 1508832..1508939 1 NC_002655.2 No significant matches; hypothetical protein 1508939 959300 Z1626 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287130.1 1508832 D 155864 CDS NP_287131.1 15801115 959302 1509005..1509202 1 NC_002655.2 No significant matches; hypothetical protein 1509202 959302 Z1627 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287131.1 1509005 D 155864 CDS NP_287132.1 15801116 959303 1509286..1509405 1 NC_002655.2 No significant matches; hypothetical protein 1509405 959303 Z1628 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287132.1 1509286 D 155864 CDS NP_287133.1 15804977 959648 join(1509932..1510384,1510384..1511055) 1 NC_002655.2 glycosyl transferase 1511055 959648 Z1629m Escherichia coli O157:H7 str. EDL933 glycosyl transferase NP_287133.1 1509932 D 155864 CDS NP_287134.1 15801117 959304 complement(1511197..1511472) 1 NC_002655.2 hypothetical protein 1511472 959304 Z1631 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287134.1 1511197 R 155864 CDS NP_287135.1 15801118 959307 complement(1511474..1511977) 1 NC_002655.2 IS1 protein InsB 1511977 959307 Z1632 Escherichia coli O157:H7 str. EDL933 IS1 protein InsB NP_287135.1 1511474 R 155864 CDS NP_287136.1 15801119 959308 complement(1512409..1512879) 1 NC_002655.2 No significant matches; hypothetical protein 1512879 959308 Z1633 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287136.1 1512409 R 155864 CDS NP_287137.1 15801120 959310 1513325..1513834 1 NC_002655.2 No significant matches; hypothetical protein 1513834 959310 Z1634 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287137.1 1513325 D 155864 CDS NP_287138.1 15801121 959311 1513923..1514546 1 NC_002655.2 No significant matches; hypothetical protein 1514546 959311 Z1635 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287138.1 1513923 D 155864 CDS NP_287139.1 15801122 959314 1514642..1514875 1 NC_002655.2 No significant matches; hypothetical protein 1514875 959314 Z1636 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287139.1 1514642 D 155864 CDS NP_287140.1 15801123 959315 complement(1514928..1515119) 1 NC_002655.2 No significant matches; hypothetical protein 1515119 959315 Z1637 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287140.1 1514928 R 155864 CDS NP_287141.1 15801124 959316 complement(1515713..1516600) 1 NC_002655.2 transposase 1516600 959316 Z1638 Escherichia coli O157:H7 str. EDL933 transposase NP_287141.1 1515713 R 155864 CDS NP_287142.1 15801125 959319 complement(1516600..1516926) 1 NC_002655.2 hypothetical protein 1516926 959319 Z1639 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287142.1 1516600 R 155864 CDS NP_287143.1 15801126 959321 1517107..1518153 1 NC_002655.2 hypothetical protein 1518153 959321 Z1640 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287143.1 1517107 D 155864 CDS NP_287144.1 15801127 959322 1518394..1518909 1 NC_002655.2 No significant matches; hypothetical protein 1518909 959322 Z1641 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287144.1 1518394 D 155864 CDS NP_287145.1 15801128 959324 1518939..1521074 1 NC_002655.2 hypothetical protein 1521074 959324 Z1642 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287145.1 1518939 D 155864 CDS NP_287146.1 15801129 959328 1521574..1522806 1 NC_002655.2 hypothetical protein 1522806 959328 Z1643 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287146.1 1521574 D 155864 CDS NP_287147.1 15801130 959329 1522791..1523429 1 NC_002655.2 hypothetical protein 1523429 959329 Z1644 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287147.1 1522791 D 155864 CDS NP_287148.1 15801131 959330 1523798..1524442 1 NC_002655.2 No significant matches; hypothetical protein 1524442 959330 Z1645 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287148.1 1523798 D 155864 CDS NP_287149.1 15801132 959331 1524490..1524645 1 NC_002655.2 No significant matches; hypothetical protein 1524645 959331 Z1646 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287149.1 1524490 D 155864 CDS NP_287150.1 15801133 959333 complement(1525140..1525388) 1 NC_002655.2 hypothetical protein 1525388 959333 Z1647 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287150.1 1525140 R 155864 CDS NP_287151.1 15801134 959334 1525442..1525867 1 NC_002655.2 hypothetical protein 1525867 959334 Z1648 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287151.1 1525442 D 155864 CDS NP_287152.1 15801135 959335 complement(1526167..1526349) 1 NC_002655.2 No significant matches; hypothetical protein 1526349 959335 Z1649 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287152.1 1526167 R 155864 CDS NP_287153.1 15801136 959336 1526678..1527550 1 NC_002655.2 hypothetical protein 1527550 959336 Z1650 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287153.1 1526678 D 155864 CDS NP_287154.1 15801137 959338 1527754..1530771 1 NC_002655.2 adhesin 1530771 959338 Z1651 Escherichia coli O157:H7 str. EDL933 adhesin NP_287154.1 1527754 D 155864 CDS NP_287155.1 15801138 959340 1530879..1533266 1 NC_002655.2 hypothetical protein 1533266 959340 Z1652 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287155.1 1530879 D 155864 CDS NP_287156.1 15801139 959341 1533263..1534168 1 NC_002655.2 hypothetical protein 1534168 959341 Z1653 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287156.1 1533263 D 155864 CDS NP_287157.1 15801140 959342 1534165..1535235 1 NC_002655.2 hypothetical protein 1535235 959342 Z1654 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287157.1 1534165 D 155864 CDS NP_287158.1 15801141 959343 1535575..1536393 1 NC_002655.2 hypothetical protein 1536393 959343 Z1655 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287158.1 1535575 D 155864 CDS NP_287159.1 15801142 959345 1536484..1536969 1 NC_002655.2 hypothetical protein 1536969 959345 Z1656 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287159.1 1536484 D 155864 CDS NP_287160.1 15801143 959346 1536985..1537461 1 NC_002655.2 RadC family DNA repair protein 1537461 959346 Z1657 Escherichia coli O157:H7 str. EDL933 RadC family DNA repair protein NP_287160.1 1536985 D 155864 CDS NP_287161.1 15801144 959347 1537908..1538282 1 NC_002655.2 structural protein 1538282 959347 Z1658 Escherichia coli O157:H7 str. EDL933 structural protein NP_287161.1 1537908 D 155864 CDS NP_287162.1 15801145 959348 complement(1538585..1539472) 1 NC_002655.2 transposase for IS629 1539472 959348 Z1660 Escherichia coli O157:H7 str. EDL933 transposase for IS629 NP_287162.1 1538585 R 155864 CDS NP_287163.1 15801146 959350 complement(1539472..1539798) 1 NC_002655.2 hypothetical protein 1539798 959350 Z1661 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287163.1 1539472 R 155864 CDS NP_287164.1 15801147 959353 1540013..1540504 1 NC_002655.2 hypothetical protein 1540504 959353 Z1662 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287164.1 1540013 D 155864 CDS NP_287165.1 15801148 959354 1540471..1540713 1 NC_002655.2 hypothetical protein 1540713 959354 Z1663 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287165.1 1540471 D 155864 CDS NP_287166.1 15801149 959356 1540798..1541640 1 NC_002655.2 hypothetical protein 1541640 959356 Z1664 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287166.1 1540798 D 155864 CDS NP_287167.1 15801150 959358 1542072..1543049 1 NC_002655.2 dehydrogenase 1543049 ycdW 959358 ycdW Escherichia coli O157:H7 str. EDL933 dehydrogenase NP_287167.1 1542072 D 155864 CDS NP_287168.1 15801151 959359 1543104..1543841 1 NC_002655.2 hydrolase 1543841 ycdX 959359 ycdX Escherichia coli O157:H7 str. EDL933 hydrolase NP_287168.1 1543104 D 155864 CDS NP_287169.1 15801152 959360 1543865..1544419 1 NC_002655.2 oxidoreductase component 1544419 ycdY 959360 ycdY Escherichia coli O157:H7 str. EDL933 oxidoreductase component NP_287169.1 1543865 D 155864 CDS NP_287170.1 15801153 959362 1544473..1545012 1 NC_002655.2 hypothetical protein 1545012 ycdZ 959362 ycdZ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287170.1 1544473 D 155864 CDS NP_287171.1 15801154 959365 complement(1545076..1545909) 1 NC_002655.2 curli production assembly/transport component, 2nd curli operon 1545909 csgG 959365 csgG Escherichia coli O157:H7 str. EDL933 curli production assembly/transport component, 2nd curli operon NP_287171.1 1545076 R 155864 CDS NP_287172.1 15801155 959366 complement(1545936..1546352) 1 NC_002655.2 nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgF 1546352 csgF 959366 csgF Escherichia coli O157:H7 str. EDL933 curli assembly protein CsgF NP_287172.1 1545936 R 155864 CDS NP_287173.1 15801156 959367 complement(1546377..1546766) 1 NC_002655.2 chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgE 1546766 csgE 959367 csgE Escherichia coli O157:H7 str. EDL933 curli assembly protein CsgE NP_287173.1 1546377 R 155864 CDS NP_287174.1 15801157 959369 complement(1546771..1547421) 1 NC_002655.2 activates the csgBA and csgDEFG operons involved in biofilm formation; DNA-binding transcriptional regulator CsgD 1547421 csgD 959369 csgD Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator CsgD NP_287174.1 1546771 R 155864 CDS NP_287175.1 15801158 959370 1548176..1548631 1 NC_002655.2 CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface; curlin minor subunit 1548631 csgB 959370 csgB Escherichia coli O157:H7 str. EDL933 curlin minor subunit NP_287175.1 1548176 D 155864 CDS NP_287176.1 15801159 959371 1548672..1549130 1 NC_002655.2 cryptic curlin major subunit 1549130 csgA 959371 csgA Escherichia coli O157:H7 str. EDL933 cryptic curlin major subunit NP_287176.1 1548672 D 155864 CDS NP_287177.1 15801160 959373 1549189..1549521 1 NC_002655.2 involved in autoagglutination of curliated cells; not involved in production of curli fibers; autoagglutination protein 1549521 csgC 959373 csgC Escherichia coli O157:H7 str. EDL933 autoagglutination protein NP_287177.1 1549189 D 155864 CDS NP_287178.1 15801161 959374 1549642..1549953 1 NC_002655.2 hypothetical protein 1549953 959374 Z1678 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287178.1 1549642 D 155864 CDS NP_287179.1 15801162 959375 1550048..1550581 1 NC_002655.2 hypothetical protein 1550581 959375 Z1679 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287179.1 1550048 D 155864 CDS NP_287180.1 15801163 959376 1550523..1552004 1 NC_002655.2 synthase 1552004 ymdC 959376 ymdC Escherichia coli O157:H7 str. EDL933 synthase NP_287180.1 1550523 D 155864 CDS NP_287181.1 15801164 959379 complement(1552012..1553169) 1 NC_002655.2 required for the transfer of succinyl residues to the glucan backbone; glucans biosynthesis protein 1553169 mdoC 959379 mdoC Escherichia coli O157:H7 str. EDL933 glucans biosynthesis protein NP_287181.1 1552012 R 155864 CDS NP_287182.1 15801165 959380 1553562..1555097 1 NC_002655.2 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan; glucan biosynthesis protein G 1555097 mdoG 959380 mdoG Escherichia coli O157:H7 str. EDL933 glucan biosynthesis protein G NP_287182.1 1553562 D 155864 CDS NP_287183.1 15801166 959381 1555090..1557633 1 NC_002655.2 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space; glucosyltransferase MdoH 1557633 mdoH 959381 mdoH Escherichia coli O157:H7 str. EDL933 glucosyltransferase MdoH NP_287183.1 1555090 D 155864 CDS NP_287184.1 15801167 959382 1557806..1558033 1 NC_002655.2 hypothetical protein 1558033 yceK 959382 yceK Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287184.1 1557806 D 155864 CDS NP_287185.1 15801168 959385 complement(1558034..1558411) 1 NC_002655.2 hypothetical protein 1558411 msyB 959385 msyB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287185.1 1558034 R 155864 CDS NP_287186.1 15801169 959386 complement(1558438..1558536) 1 NC_002655.2 hypothetical protein 1558536 959386 Z1687 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287186.1 1558438 R 155864 CDS NP_287187.1 15801170 959387 complement(1558491..1559558) 1 NC_002655.2 hypothetical protein 1559558 yceE 959387 yceE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287187.1 1558491 R 155864 CDS NP_287188.1 15801171 959388 complement(1559889..1560809) 1 NC_002655.2 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 1560809 959388 Z1690 Escherichia coli O157:H7 str. EDL933 lipid A biosynthesis lauroyl acyltransferase NP_287188.1 1559889 R 155864 CDS NP_287189.1 15801172 959389 1561034..1562086 1 NC_002655.2 hypothetical protein 1562086 yceA 959389 yceA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287189.1 1561034 D 155864 CDS NP_287190.1 15801173 959391 complement(1562128..1562703) 1 NC_002655.2 hypothetical protein 1562703 yceI 959391 yceI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287190.1 1562128 R 155864 CDS NP_287191.1 15801174 959393 complement(1562707..1563273) 1 NC_002655.2 cytochrome 1563273 959393 Z1693 Escherichia coli O157:H7 str. EDL933 cytochrome NP_287191.1 1562707 R 155864 CDS NP_287192.1 15801175 959395 complement(1563534..1563674) 1 NC_002655.2 hypothetical protein 1563674 yceO 959395 yceO Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287192.1 1563534 R 155864 CDS NP_287193.1 15801176 959396 complement(1563695..1564813) 1 NC_002655.2 catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids; N-methyltryptophan oxidase 1564813 solA 959396 solA Escherichia coli O157:H7 str. EDL933 N-methyltryptophan oxidase NP_287193.1 1563695 R 155864 CDS NP_287194.1 15801177 959397 complement(1564928..1565182) 1 NC_002655.2 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssS 1565182 bssS 959397 bssS Escherichia coli O157:H7 str. EDL933 biofilm formation regulatory protein BssS NP_287194.1 1564928 R 155864 CDS NP_287195.1 15801178 959399 complement(1565472..1565717) 1 NC_002655.2 DNA damage-inducible protein I 1565717 dinI 959399 dinI Escherichia coli O157:H7 str. EDL933 DNA damage-inducible protein I NP_287195.1 1565472 R 155864 CDS NP_287196.1 15801179 959400 complement(1565791..1566837) 1 NC_002655.2 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 1566837 pyrC 959400 pyrC Escherichia coli O157:H7 str. EDL933 dihydroorotase NP_287196.1 1565791 R 155864 CDS NP_287197.1 15801180 959401 complement(1566943..1567503) 1 NC_002655.2 hypothetical protein 1567503 yceB 959401 yceB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287197.1 1566943 R 155864 CDS NP_287198.1 15801181 959403 complement(1567637..1568284) 1 NC_002655.2 cofactor involved in the reduction of disulfides; glutaredoxin 1568284 grxB 959403 grxB Escherichia coli O157:H7 str. EDL933 glutaredoxin NP_287198.1 1567637 R 155864 CDS NP_287199.2 161367621 959404 complement(1568348..1569556) 1 NC_002655.2 Confers resistance to norfloxacin and enoxacin; multidrug resistance protein MdtH 1569556 yceL 959404 yceL Escherichia coli O157:H7 str. EDL933 multidrug resistance protein MdtH NP_287199.2 1568348 R 155864 CDS NP_287200.1 15801183 959405 1569792..1570376 1 NC_002655.2 ribosomal-protein-S5-alanine N-acetyltransferase 1570376 rimJ 959405 rimJ Escherichia coli O157:H7 str. EDL933 ribosomal-protein-S5-alanine N-acetyltransferase NP_287200.1 1569792 D 155864 CDS NP_287201.1 15801184 959406 1570387..1571034 1 NC_002655.2 hypothetical protein 1571034 yceH 959406 yceH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287201.1 1570387 D 155864 CDS NP_287202.1 15801185 959407 1571036..1571959 1 NC_002655.2 virulence factor 1571959 mviM 959407 mviM Escherichia coli O157:H7 str. EDL933 virulence factor NP_287202.1 1571036 D 155864 CDS NP_287203.1 15801186 959408 1572069..1573604 1 NC_002655.2 virulence factor 1573604 mviN 959408 mviN Escherichia coli O157:H7 str. EDL933 virulence factor NP_287203.1 1572069 D 155864 CDS NP_287204.1 15801187 959409 complement(1573644..1574060) 1 NC_002655.2 flagellar synthesis protein FlgN 1574060 flgN 959409 flgN Escherichia coli O157:H7 str. EDL933 flagellar synthesis protein FlgN NP_287204.1 1573644 R 155864 CDS NP_287205.1 15801188 959410 complement(1574065..1574358) 1 NC_002655.2 regulates the flagellar specific sigma28 transcription factor; anti-sigma-28 factor FlgM 1574358 flgM 959410 flgM Escherichia coli O157:H7 str. EDL933 anti-sigma-28 factor FlgM NP_287205.1 1574065 R 155864 CDS NP_287206.1 15801189 959412 complement(1574434..1575093) 1 NC_002655.2 required for the assembly of the flagellar basal body P-ring; flagellar basal body P-ring biosynthesis protein FlgA 1575093 flgA 959412 flgA Escherichia coli O157:H7 str. EDL933 flagellar basal body P-ring biosynthesis protein FlgA NP_287206.1 1574434 R 155864 CDS NP_287207.1 15801190 959413 1575248..1575664 1 NC_002655.2 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella; flagellar basal-body rod protein FlgB 1575664 flgB 959413 flgB Escherichia coli O157:H7 str. EDL933 flagellar basal-body rod protein FlgB NP_287207.1 1575248 D 155864 CDS NP_287208.1 15801191 959415 1575668..1576072 1 NC_002655.2 with FlgF and B makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgC 1576072 flgC 959415 flgC Escherichia coli O157:H7 str. EDL933 flagellar basal body rod protein FlgC NP_287208.1 1575668 D 155864 CDS NP_287209.1 15801192 959416 1576084..1576779 1 NC_002655.2 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production; flagellar basal body rod modification protein 1576779 flgD 959416 flgD Escherichia coli O157:H7 str. EDL933 flagellar basal body rod modification protein NP_287209.1 1576084 D 155864 CDS NP_287210.1 15801193 959417 1576804..1578009 1 NC_002655.2 the hook connects flagellar basal body to the flagellar filament; flagellar hook protein FlgE 1578009 flgE 959417 flgE Escherichia coli O157:H7 str. EDL933 flagellar hook protein FlgE NP_287210.1 1576804 D 155864 CDS NP_287211.1 15801194 959418 1578029..1578784 1 NC_002655.2 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgF 1578784 flgF 959418 flgF Escherichia coli O157:H7 str. EDL933 flagellar basal body rod protein FlgF NP_287211.1 1578029 D 155864 CDS NP_287212.1 15801195 959421 1578922..1579704 1 NC_002655.2 makes up the distal portion of the flagellar basal body rod; flagellar basal body rod protein FlgG 1579704 flgG 959421 flgG Escherichia coli O157:H7 str. EDL933 flagellar basal body rod protein FlgG NP_287212.1 1578922 D 155864 CDS NP_287213.1 15801196 959422 1579757..1580455 1 NC_002655.2 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod; flagellar basal body L-ring protein 1580455 flgH 959422 flgH Escherichia coli O157:H7 str. EDL933 flagellar basal body L-ring protein NP_287213.1 1579757 D 155864 CDS NP_287214.1 15801197 959423 1580467..1581564 1 NC_002655.2 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum; flagellar basal body P-ring biosynthesis protein FlgA 1581564 flgI 959423 flgI Escherichia coli O157:H7 str. EDL933 flagellar basal body P-ring biosynthesis protein FlgA NP_287214.1 1580467 D 155864 CDS NP_287215.1 15801198 959424 1581564..1582505 1 NC_002655.2 Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; flagellar rod assembly protein/muramidase FlgJ 1582505 flgJ 959424 flgJ Escherichia coli O157:H7 str. EDL933 flagellar rod assembly protein/muramidase FlgJ NP_287215.1 1581564 D 155864 CDS NP_287216.1 15801199 959425 1582571..1584214 1 NC_002655.2 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook; flagellar hook-associated protein FlgK 1584214 flgK 959425 flgK Escherichia coli O157:H7 str. EDL933 flagellar hook-associated protein FlgK NP_287216.1 1582571 D 155864 CDS NP_287217.1 15801200 959427 1584226..1585179 1 NC_002655.2 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes; flagellar hook-associated protein FlgL 1585179 flgL 959427 flgL Escherichia coli O157:H7 str. EDL933 flagellar hook-associated protein FlgL NP_287217.1 1584226 D 155864 CDS NP_287218.1 15801201 959428 complement(1585374..1588559) 1 NC_002655.2 bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase; ribonuclease E 1588559 rne 959428 rne Escherichia coli O157:H7 str. EDL933 ribonuclease E NP_287218.1 1585374 R 155864 CDS NP_287219.1 15801202 959429 1588640..1589014 1 NC_002655.2 hypothetical protein 1589014 959429 Z1724 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287219.1 1588640 D 155864 CDS NP_287220.1 15801203 959430 1589132..1590091 1 NC_002655.2 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C 1590091 yceC 959430 yceC Escherichia coli O157:H7 str. EDL933 23S rRNA pseudouridylate synthase C NP_287220.1 1589132 D 155864 CDS NP_287221.2 161367620 959431 complement(1590192..1590776) 1 NC_002655.2 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 1590776 maf 959431 maf Escherichia coli O157:H7 str. EDL933 Maf-like protein NP_287221.2 1590192 R 155864 CDS NP_287222.1 15801205 959432 1590975..1591496 1 NC_002655.2 hypothetical protein 1591496 yceD 959432 yceD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287222.1 1590975 D 155864 CDS NP_287223.1 15801206 959433 1591548..1591721 1 NC_002655.2 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1591721 rpmF 959433 rpmF Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L32 NP_287223.1 1591548 D 155864 CDS NP_287224.2 161367619 959434 1591802..1592872 1 NC_002655.2 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 1592872 plsX 959434 plsX Escherichia coli O157:H7 str. EDL933 glycerol-3-phosphate acyltransferase PlsX NP_287224.2 1591802 D 155864 CDS NP_287225.1 15801208 959435 1592940..1593893 1 NC_002655.2 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 1593893 fabH 959435 fabH Escherichia coli O157:H7 str. EDL933 3-oxoacyl-ACP synthase NP_287225.1 1592940 D 155864 CDS NP_287226.1 15801209 959436 1593909..1594838 1 NC_002655.2 ACP S-malonyltransferase 1594838 fabD 959436 fabD Escherichia coli O157:H7 str. EDL933 ACP S-malonyltransferase NP_287226.1 1593909 D 155864 CDS NP_287227.1 15801210 959437 1594851..1595585 1 NC_002655.2 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 1595585 fabG 959437 fabG Escherichia coli O157:H7 str. EDL933 3-ketoacyl-ACP reductase NP_287227.1 1594851 D 155864 CDS NP_287228.1 15801211 959438 1595796..1596032 1 NC_002655.2 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1596032 acpP 959438 acpP Escherichia coli O157:H7 str. EDL933 acyl carrier protein NP_287228.1 1595796 D 155864 CDS NP_287229.1 15801212 959439 1596120..1597361 1 NC_002655.2 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 1597361 fabF 959439 fabF Escherichia coli O157:H7 str. EDL933 3-oxoacyl-ACP synthase NP_287229.1 1596120 D 155864 CDS NP_287230.1 15801213 959440 1597481..1598290 1 NC_002655.2 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase 1598290 pabC 959440 pabC Escherichia coli O157:H7 str. EDL933 4-amino-4-deoxychorismate lyase NP_287230.1 1597481 D 155864 CDS NP_287231.1 15801214 959444 1598293..1599315 1 NC_002655.2 hypothetical protein 1599315 yceG 959444 yceG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287231.1 1598293 D 155864 CDS NP_287232.1 15801215 959446 1599305..1599946 1 NC_002655.2 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 1599946 tmk 959446 tmk Escherichia coli O157:H7 str. EDL933 thymidylate kinase NP_287232.1 1599305 D 155864 CDS NP_287233.1 15801216 959447 1599943..1600947 1 NC_002655.2 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 1600947 holB 959447 holB Escherichia coli O157:H7 str. EDL933 DNA polymerase III subunit delta' NP_287233.1 1599943 D 155864 CDS NP_287234.1 15801217 959448 1600958..1601755 1 NC_002655.2 metallodependent hydrolase 1601755 ycfH 959448 ycfH Escherichia coli O157:H7 str. EDL933 metallodependent hydrolase NP_287234.1 1600958 D 155864 CDS NP_287235.1 15801218 959449 1602051..1603484 1 NC_002655.2 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucose-specific transporter subunit IIBC 1603484 ptsG 959449 ptsG Escherichia coli O157:H7 str. EDL933 PTS system glucose-specific transporter subunit IIBC NP_287235.1 1602051 D 155864 CDS NP_287236.1 15801219 959453 complement(1603544..1605733) 1 NC_002655.2 ferric-rhodotorulic acid outer membrane transporter 1605733 fhuE 959453 fhuE Escherichia coli O157:H7 str. EDL933 ferric-rhodotorulic acid outer membrane transporter NP_287236.1 1603544 R 155864 CDS NP_287237.1 15801220 959454 1606087..1606446 1 NC_002655.2 purine nucleoside phosphoramidase 1606446 ycfF 959454 ycfF Escherichia coli O157:H7 str. EDL933 purine nucleoside phosphoramidase NP_287237.1 1606087 D 155864 CDS NP_287238.1 15801221 959456 1606449..1606826 1 NC_002655.2 hypothetical protein 1606826 ycfL 959456 ycfL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287238.1 1606449 D 155864 CDS NP_287239.1 15801222 959457 1606840..1607481 1 NC_002655.2 hypothetical protein 1607481 ycfM 959457 ycfM Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287239.1 1606840 D 155864 CDS NP_287240.1 15801223 959458 1607462..1608286 1 NC_002655.2 catalyzes the phosphorylation of thiamine to thiamine phosphate; thiamine kinase 1608286 thiK 959458 thiK Escherichia coli O157:H7 str. EDL933 thiamine kinase NP_287240.1 1607462 D 155864 CDS NP_287241.1 15801224 959459 1608297..1609322 1 NC_002655.2 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 1609322 ycfO 959459 ycfO Escherichia coli O157:H7 str. EDL933 beta-hexosaminidase NP_287241.1 1608297 D 155864 CDS NP_287242.2 161367618 959460 1609345..1609887 1 NC_002655.2 hypothetical protein 1609887 ycfP 959460 ycfP Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287242.2 1609345 D 155864 CDS NP_287243.1 15801226 959461 1610288..1611592 1 NC_002655.2 NADH dehydrogenase 1611592 ndh 959461 ndh Escherichia coli O157:H7 str. EDL933 NADH dehydrogenase NP_287243.1 1610288 D 155864 CDS NP_287244.1 15801227 959463 1611819..1612358 1 NC_002655.2 hypothetical protein 1612358 ycfJ 959463 ycfJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287244.1 1611819 D 155864 CDS NP_287245.1 15801228 959464 complement(1612420..1613130) 1 NC_002655.2 hypothetical protein 1613130 ycfQ 959464 ycfQ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287245.1 1612420 R 155864 CDS NP_287246.1 15801229 959465 1613293..1613550 1 NC_002655.2 hypothetical protein 1613550 ycfR 959465 ycfR Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287246.1 1613293 D 155864 CDS NP_287247.1 15801230 959467 complement(1613633..1614595) 1 NC_002655.2 hypothetical protein 1614595 ycfS 959467 ycfS Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287247.1 1613633 R 155864 CDS NP_287248.1 15801231 959468 complement(1614739..1618185) 1 NC_002655.2 transcription-repair coupling factor 1618185 mfd 959468 mfd Escherichia coli O157:H7 str. EDL933 transcription-repair coupling factor NP_287248.1 1614739 R 155864 CDS NP_287249.1 15801232 959469 complement(1618313..1619386) 1 NC_002655.2 hypothetical protein 1619386 ycfT 959469 ycfT Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287249.1 1618313 R 155864 CDS NP_287250.1 15801233 959470 1619648..1620847 1 NC_002655.2 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolC 1620847 ycfU 959470 ycfU Escherichia coli O157:H7 str. EDL933 outer membrane-specific lipoprotein transporter subunit LolC NP_287250.1 1619648 D 155864 CDS NP_287251.2 161367617 959471 1620840..1621541 1 NC_002655.2 outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone; lipoprotein transporter ATP-binding subunit 1621541 lolD 959471 lolD Escherichia coli O157:H7 str. EDL933 lipoprotein transporter ATP-binding subunit NP_287251.2 1620840 D 155864 CDS NP_287252.1 15801235 959472 1621541..1622785 1 NC_002655.2 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE 1622785 ycfW 959472 ycfW Escherichia coli O157:H7 str. EDL933 outer membrane-specific lipoprotein transporter subunit LolE NP_287252.1 1621541 D 155864 CDS NP_287253.1 15801236 959473 1622814..1623725 1 NC_002655.2 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase 1623725 ycfX 959473 ycfX Escherichia coli O157:H7 str. EDL933 N-acetyl-D-glucosamine kinase NP_287253.1 1622814 D 155864 CDS NP_287254.1 15801237 959474 1623741..1624562 1 NC_002655.2 Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 1624562 cobB 959474 cobB Escherichia coli O157:H7 str. EDL933 NAD-dependent deacetylase NP_287254.1 1623741 D 155864 CDS NP_287255.1 15801238 959475 complement(1624718..1625764) 1 NC_002655.2 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate; spermidine/putrescine ABC transporter substrate-binding protein 1625764 potD 959475 potD Escherichia coli O157:H7 str. EDL933 spermidine/putrescine ABC transporter substrate-binding protein NP_287255.1 1624718 R 155864 CDS NP_287256.1 15801239 959476 complement(1625761..1626555) 1 NC_002655.2 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter 1626555 potC 959476 potC Escherichia coli O157:H7 str. EDL933 spermidine/putrescine ABC transporter NP_287256.1 1625761 R 155864 CDS NP_287257.1 15801240 959477 complement(1626722..1627840) 1 NC_002655.2 hypothetical protein 1627840 intN 959477 intN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287257.1 1626722 R 155864 CDS NP_287258.1 15801241 959478 complement(1627809..1628087) 1 NC_002655.2 No significant matches; excisionase 1628087 xisN 959478 xisN Escherichia coli O157:H7 str. EDL933 excisionase NP_287258.1 1627809 R 155864 CDS NP_287259.1 15801242 959480 complement(1628140..1628484) 1 NC_002655.2 No significant matches; hypothetical protein 1628484 959480 Z1766 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287259.1 1628140 R 155864 CDS NP_287260.1 15801243 959481 1628545..1629177 1 NC_002655.2 No significant matches; hypothetical protein 1629177 959481 Z1768 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287260.1 1628545 D 155864 CDS NP_287261.1 15801244 959482 complement(1629292..1629522) 1 NC_002655.2 hypothetical protein 1629522 959482 Z1769 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287261.1 1629292 R 155864 CDS NP_287262.1 15801245 959483 complement(1629760..1630236) 1 NC_002655.2 hypothetical protein 1630236 959483 Z1770 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287262.1 1629760 R 155864 CDS NP_287263.1 15801246 959484 1630361..1630684 1 NC_002655.2 hypothetical protein 1630684 959484 Z1771 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287263.1 1630361 D 155864 CDS NP_287264.1 15801247 959485 1630668..1631093 1 NC_002655.2 hypothetical protein 1631093 959485 Z1772 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287264.1 1630668 D 155864 CDS NP_287265.1 15801248 959486 1631162..1632199 1 NC_002655.2 hypothetical protein 1632199 959486 Z1773 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287265.1 1631162 D 155864 CDS NP_287266.1 15801249 959487 1631991..1632653 1 NC_002655.2 hypothetical protein 1632653 959487 Z1774 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287266.1 1631991 D 155864 CDS NP_287267.1 15801250 959488 1632687..1633403 1 NC_002655.2 hypothetical protein 1633403 959488 Z1775 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287267.1 1632687 D 155864 CDS NP_287268.1 15801251 959489 1633400..1633717 1 NC_002655.2 No significant matches; hypothetical protein 1633717 959489 Z1776 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287268.1 1633400 D 155864 CDS NP_287269.1 15801252 959490 1633714..1634016 1 NC_002655.2 hypothetical protein 1634016 959490 Z1777 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287269.1 1633714 D 155864 CDS NP_287270.1 15801253 959491 1634006..1634323 1 NC_002655.2 hypothetical protein 1634323 959491 Z1778 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287270.1 1634006 D 155864 CDS NP_287271.1 15801254 959492 1634277..1634594 1 NC_002655.2 No significant matches; hypothetical protein 1634594 959492 Z1779 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287271.1 1634277 D 155864 CDS NP_287272.1 15801255 959493 1634581..1635018 1 NC_002655.2 hypothetical protein 1635018 959493 Z1780 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287272.1 1634581 D 155864 CDS NP_287273.1 15801256 959499 1635214..1635801 1 NC_002655.2 hypothetical protein 1635801 959499 Z1781 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287273.1 1635214 D 155864 CDS NP_287274.1 15801257 959501 1635917..1636021 1 NC_002655.2 No significant matches; hypothetical protein 1636021 959501 Z1782 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287274.1 1635917 D 155864 CDS NP_287275.1 15801258 959503 1636210..1636422 1 NC_002655.2 Gef-like protein encoded by prophage CP-933N 1636422 959503 Z1783 Escherichia coli O157:H7 str. EDL933 Gef-like protein encoded by prophage CP-933N NP_287275.1 1636210 D 155864 CDS NP_287276.1 15801259 959505 1636870..1637919 1 NC_002655.2 hypothetical protein 1637919 959505 Z1784 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287276.1 1636870 D 155864 CDS NP_287277.1 15801260 959510 1637932..1638303 1 NC_002655.2 endodeoxyribonuclease of prophage CP-933N 1638303 959510 Z1785 Escherichia coli O157:H7 str. EDL933 endodeoxyribonuclease of prophage CP-933N NP_287277.1 1637932 D 155864 CDS NP_287278.1 15801261 959511 1638293..1638664 1 NC_002655.2 Q antiterminator of prophage CP-933N 1638664 959511 Z1786 Escherichia coli O157:H7 str. EDL933 Q antiterminator of prophage CP-933N NP_287278.1 1638293 D 155864 CDS NP_287279.1 15801262 959512 1638810..1639634 1 NC_002655.2 hypothetical protein 1639634 959512 Z1787 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287279.1 1638810 D 155864 CDS NP_287280.1 15801263 959513 1639921..1640160 1 NC_002655.2 hypothetical protein 1640160 959513 Z1788 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287280.1 1639921 D 155864 CDS NP_287281.1 15801264 959517 1640255..1640968 1 NC_002655.2 envelope protein encoded within prophage CP-933N 1640968 959517 Z1789 Escherichia coli O157:H7 str. EDL933 envelope protein encoded within prophage CP-933N NP_287281.1 1640255 D 155864 CDS NP_287282.1 15801265 959534 1641736..1643589 1 NC_002655.2 hypothetical protein 1643589 959534 Z1793 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287282.1 1641736 D 155864 CDS NP_287283.1 15801266 959539 1643640..1643954 1 NC_002655.2 holin protein 1643954 959539 Z1794 Escherichia coli O157:H7 str. EDL933 holin protein NP_287283.1 1643640 D 155864 CDS NP_287284.1 15801267 959544 1643959..1644303 1 NC_002655.2 hypothetical protein 1644303 959544 Z1795 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287284.1 1643959 D 155864 CDS NP_287285.1 15801268 959547 1644354..1644887 1 NC_002655.2 endolysin of prophage CP-933N 1644887 959547 Z1796 Escherichia coli O157:H7 str. EDL933 endolysin of prophage CP-933N NP_287285.1 1644354 D 155864 CDS NP_287286.1 15801269 959548 1645161..1645856 1 NC_002655.2 antirepressor of prophage CP-933N 1645856 959548 Z1797 Escherichia coli O157:H7 str. EDL933 antirepressor of prophage CP-933N NP_287286.1 1645161 D 155864 CDS NP_287287.1 15801270 959549 1646079..1646552 1 NC_002655.2 endopeptidase of prophage CP-933N 1646552 959549 Z1798 Escherichia coli O157:H7 str. EDL933 endopeptidase of prophage CP-933N NP_287287.1 1646079 D 155864 CDS NP_287288.1 15801271 959550 1646885..1647217 1 NC_002655.2 hypothetical protein 1647217 959550 Z1799 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287288.1 1646885 D 155864 CDS NP_287289.1 15801272 959551 1647591..1647956 1 NC_002655.2 hypothetical protein 1647956 959551 Z1800 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287289.1 1647591 D 155864 CDS NP_287290.1 15801273 959553 1648245..1648808 1 NC_002655.2 No significant matches; hypothetical protein 1648808 959553 Z1802 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287290.1 1648245 D 155864 CDS NP_287291.1 15801274 959554 1648805..1650466 1 NC_002655.2 terminase encoded by prophage CP-933N 1650466 959554 Z1803 Escherichia coli O157:H7 str. EDL933 terminase encoded by prophage CP-933N NP_287291.1 1648805 D 155864 CDS NP_287292.1 15801275 959555 1650530..1652467 1 NC_002655.2 hypothetical protein 1652467 959555 Z1804 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287292.1 1650530 D 155864 CDS NP_287293.1 15801276 959556 1652512..1652733 1 NC_002655.2 No significant matches; hypothetical protein 1652733 959556 Z1805 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287293.1 1652512 D 155864 CDS NP_287294.1 15801277 959557 1652679..1655258 1 NC_002655.2 hypothetical protein 1655258 959557 Z1806 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287294.1 1652679 D 155864 CDS NP_287295.1 15801278 959559 1655261..1655587 1 NC_002655.2 No significant matches; hypothetical protein 1655587 959559 Z1807 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287295.1 1655261 D 155864 CDS NP_287296.1 15801279 959562 1655744..1655947 1 NC_002655.2 hypothetical protein 1655947 959562 Z1808 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287296.1 1655744 D 155864 CDS NP_287297.1 15801280 959564 1655944..1656390 1 NC_002655.2 hypothetical protein 1656390 959564 Z1809 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287297.1 1655944 D 155864 CDS NP_287298.1 15801281 959566 1656387..1656731 1 NC_002655.2 hypothetical protein 1656731 959566 Z1810 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287298.1 1656387 D 155864 CDS NP_287299.1 15801282 959567 1656728..1657513 1 NC_002655.2 tail component encoded by prophage CP-933N 1657513 959567 Z1811 Escherichia coli O157:H7 str. EDL933 tail component encoded by prophage CP-933N NP_287299.1 1656728 D 155864 CDS NP_287300.1 15801283 959568 1657480..1657902 1 NC_002655.2 tail assembly chaperone encoded by prophage CP-933N 1657902 959568 Z1812 Escherichia coli O157:H7 str. EDL933 tail assembly chaperone encoded by prophage CP-933N NP_287300.1 1657480 D 155864 CDS NP_287301.1 15801284 959569 1657926..1658207 1 NC_002655.2 hypothetical protein 1658207 959569 Z1813 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287301.1 1657926 D 155864 CDS NP_287302.1 15801285 959570 1658259..1659452 1 NC_002655.2 hypothetical protein 1659452 959570 Z1814 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287302.1 1658259 D 155864 CDS NP_287303.1 15801286 959572 1659673..1660371 1 NC_002655.2 tail component L homolog encoded by prophage CP-933N 1660371 959572 Z1815 Escherichia coli O157:H7 str. EDL933 tail component L homolog encoded by prophage CP-933N NP_287303.1 1659673 D 155864 CDS NP_287304.1 15801287 959573 1660546..1660704 1 NC_002655.2 No significant matches; hypothetical protein 1660704 959573 Z1816 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287304.1 1660546 D 155864 CDS NP_287305.1 15801288 959574 1660751..1660861 1 NC_002655.2 No significant matches; hypothetical protein 1660861 959574 Z1817 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287305.1 1660751 D 155864 CDS NP_287306.1 15801289 959576 1661164..1662042 1 NC_002655.2 antirepressor protein encoded by prophage CP-933N 1662042 959576 Z1818 Escherichia coli O157:H7 str. EDL933 antirepressor protein encoded by prophage CP-933N NP_287306.1 1661164 D 155864 CDS NP_287307.1 15801290 959578 1662096..1662833 1 NC_002655.2 tail component K homolog encoded by prophage CP-933N 1662833 959578 Z1819 Escherichia coli O157:H7 str. EDL933 tail component K homolog encoded by prophage CP-933N NP_287307.1 1662096 D 155864 CDS NP_287308.1 15801291 959579 1662830..1663015 1 NC_002655.2 hypothetical protein 1663015 959579 Z1820 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287308.1 1662830 D 155864 CDS NP_287309.1 15801292 959580 complement(1663272..1663508) 1 NC_002655.2 No significant matches; hypothetical protein 1663508 959580 Z1821 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287309.1 1663272 R 155864 CDS NP_287310.1 15801293 959581 1663537..1665486 1 NC_002655.2 hypothetical protein 1665486 959581 Z1822 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287310.1 1663537 D 155864 CDS NP_287311.1 15801294 959582 1666077..1666661 1 NC_002655.2 No significant matches; hypothetical protein 1666661 959582 Z1823 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287311.1 1666077 D 155864 CDS NP_287312.1 15801295 959583 1666666..1669479 1 NC_002655.2 hypothetical protein 1669479 959583 Z1824 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287312.1 1666666 D 155864 CDS NP_287313.1 15801296 959585 complement(1670022..1670927) 1 NC_002655.2 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1670927 959585 Z1825 Escherichia coli O157:H7 str. EDL933 insertion element IS2 transposase InsD NP_287313.1 1670022 R 155864 CDS NP_287314.1 15801297 959586 complement(1671089..1671250) 1 NC_002655.2 IS encoded protein 1671250 959586 Z1826 Escherichia coli O157:H7 str. EDL933 IS encoded protein NP_287314.1 1671089 R 155864 CDS NP_287315.1 15801298 959587 1671207..1671560 1 NC_002655.2 IS encoded protein 1671560 959587 Z1827 Escherichia coli O157:H7 str. EDL933 IS encoded protein NP_287315.1 1671207 D 155864 CDS NP_287316.1 15801299 959588 complement(1672124..1673485) 1 NC_002655.2 No significant matches; hypothetical protein 1673485 959588 Z1829 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287316.1 1672124 R 155864 CDS NP_287317.1 15801300 959589 complement(1673849..1674712) 1 NC_002655.2 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter 1674712 potB 959589 potB Escherichia coli O157:H7 str. EDL933 spermidine/putrescine ABC transporter NP_287317.1 1673849 R 155864 CDS NP_287318.1 15801301 959590 complement(1674696..1675832) 1 NC_002655.2 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase 1675832 potA 959590 potA Escherichia coli O157:H7 str. EDL933 putrescine/spermidine ABC transporter ATPase NP_287318.1 1674696 R 155864 CDS NP_287319.1 15801302 959591 1676082..1677308 1 NC_002655.2 catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 1677308 pepT 959591 pepT Escherichia coli O157:H7 str. EDL933 peptidase T NP_287319.1 1676082 D 155864 CDS NP_287320.1 15801303 959592 complement(1677357..1678487) 1 NC_002655.2 hypothetical protein 1678487 ycfD 959592 ycfD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287320.1 1677357 R 155864 CDS NP_287321.1 15801304 959593 1678706..1679956 1 NC_002655.2 integrase of prophage CP-933C 1679956 959593 Z1835 Escherichia coli O157:H7 str. EDL933 integrase of prophage CP-933C NP_287321.1 1678706 D 155864 CDS NP_287323.1 15801306 959595 complement(1680376..1680546) 1 NC_002655.2 No significant matches; hypothetical protein 1680546 959595 Z1838 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287323.1 1680376 R 155864 CDS NP_287324.1 15801307 959596 complement(1681010..1681141) 1 NC_002655.2 No significant matches; hypothetical protein 1681141 959596 Z1839 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287324.1 1681010 R 155864 CDS NP_287325.1 15801308 959597 1681526..1681711 1 NC_002655.2 No significant matches; hypothetical protein 1681711 959597 Z1840 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287325.1 1681526 D 155864 CDS NP_287326.1 15801309 959598 1681874..1682134 1 NC_002655.2 No significant matches; hypothetical protein 1682134 959598 Z1841 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287326.1 1681874 D 155864 CDS NP_287327.1 15801310 959599 1682436..1683410 1 NC_002655.2 No significant matches; hypothetical protein 1683410 959599 Z1842 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287327.1 1682436 D 155864 CDS NP_287328.1 15801311 959600 1683407..1684567 1 NC_002655.2 No significant matches; hypothetical protein 1684567 959600 Z1843 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287328.1 1683407 D 155864 CDS NP_287329.1 15801312 959601 1684938..1685189 1 NC_002655.2 No significant matches; hypothetical protein 1685189 959601 Z1844 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287329.1 1684938 D 155864 CDS NP_287330.1 15801313 959602 1685186..1685596 1 NC_002655.2 ssDNA-binding protein 1685596 959602 Z1845 Escherichia coli O157:H7 str. EDL933 ssDNA-binding protein NP_287330.1 1685186 D 155864 CDS NP_287331.1 15801314 959603 1685926..1686228 1 NC_002655.2 No significant matches; hypothetical protein 1686228 959603 Z1846 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287331.1 1685926 D 155864 CDS NP_287332.1 15801315 959604 1686521..1687678 1 NC_002655.2 capsid protein of prophage CP-933C 1687678 959604 Z1847 Escherichia coli O157:H7 str. EDL933 capsid protein of prophage CP-933C NP_287332.1 1686521 D 155864 CDS NP_287333.1 15801316 959605 1687718..1688290 1 NC_002655.2 head maturation protease of prophage CP-933C 1688290 959605 Z1848 Escherichia coli O157:H7 str. EDL933 head maturation protease of prophage CP-933C NP_287333.1 1687718 D 155864 CDS NP_287334.1 15801317 959607 1688292..1689503 1 NC_002655.2 portal protein of prophage CP-933C 1689503 959607 Z1849 Escherichia coli O157:H7 str. EDL933 portal protein of prophage CP-933C NP_287334.1 1688292 D 155864 CDS NP_287335.1 15801318 959608 complement(1689595..1689876) 1 NC_002655.2 No significant matches; hypothetical protein 1689876 959608 Z1850 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287335.1 1689595 R 155864 CDS NP_287336.1 15801319 959610 1689835..1690131 1 NC_002655.2 hypothetical protein 1690131 959610 Z1851 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287336.1 1689835 D 155864 CDS NP_287337.1 15801320 959611 1690182..1690571 1 NC_002655.2 holin protein of prophage CP-933C 1690571 959611 Z1852 Escherichia coli O157:H7 str. EDL933 holin protein of prophage CP-933C NP_287337.1 1690182 D 155864 CDS NP_287338.1 15801321 959612 1690861..1691217 1 NC_002655.2 hypothetical protein 1691217 959612 Z1853 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287338.1 1690861 D 155864 CDS NP_287339.1 15801322 959613 1691333..1692862 1 NC_002655.2 terminase of prophage CP-933C 1692862 959613 Z1854 Escherichia coli O157:H7 str. EDL933 terminase of prophage CP-933C NP_287339.1 1691333 D 155864 CDS NP_287340.1 15801323 959614 1692876..1693157 1 NC_002655.2 No significant matches; hypothetical protein 1693157 959614 Z1855 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287340.1 1692876 D 155864 CDS NP_287341.1 15801324 959615 complement(1692900..1693238) 1 NC_002655.2 No significant matches; hypothetical protein 1693238 959615 Z1856 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287341.1 1692900 R 155864 CDS NP_287342.1 15801325 959616 complement(1693462..1693737) 1 NC_002655.2 No significant matches; hypothetical protein 1693737 959616 Z1857 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287342.1 1693462 R 155864 CDS NP_287343.1 15801326 959617 complement(1694014..1695396) 1 NC_002655.2 sensor protein PhoQ 1695396 phoQ 959617 phoQ Escherichia coli O157:H7 str. EDL933 sensor protein PhoQ NP_287343.1 1694014 R 155864 CDS NP_287344.1 15801327 959618 complement(1695474..1696145) 1 NC_002655.2 response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress; DNA-binding transcriptional regulator PhoP 1696145 phoP 959618 phoP Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator PhoP NP_287344.1 1695474 R 155864 CDS NP_287345.1 15801328 959619 complement(1696314..1697684) 1 NC_002655.2 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 1697684 purB 959619 purB Escherichia coli O157:H7 str. EDL933 adenylosuccinate lyase NP_287345.1 1696314 R 155864 CDS NP_287346.1 15801329 959647 complement(1697688..1698329) 1 NC_002655.2 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein 1698329 ycfC 959647 ycfC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287346.1 1697688 R 155864 CDS NP_287347.2 161367616 959790 complement(1698365..1699471) 1 NC_002655.2 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 1699471 mnmA 959790 mnmA Escherichia coli O157:H7 str. EDL933 tRNA-specific 2-thiouridylase MnmA NP_287347.2 1698365 R 155864 CDS NP_287348.1 15801331 959806 complement(1699525..1699986) 1 NC_002655.2 phosphohydrolase 1699986 959806 Z1863 Escherichia coli O157:H7 str. EDL933 phosphohydrolase NP_287348.1 1699525 R 155864 CDS NP_287349.1 15801332 959820 complement(1699996..1700619) 1 NC_002655.2 catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase E 1700619 ymfC 959820 ymfC Escherichia coli O157:H7 str. EDL933 23S rRNA pseudouridine synthase E NP_287349.1 1699996 R 155864 CDS NP_287350.1 15801333 959821 1700821..1702071 1 NC_002655.2 Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase 1702071 icdA 959821 icdA Escherichia coli O157:H7 str. EDL933 isocitrate dehydrogenase NP_287350.1 1700821 D 155864 CDS NP_287351.1 15801334 959822 complement(1702185..1703327) 1 NC_002655.2 integrase of prophage CP-933X 1703327 959822 Z1866 Escherichia coli O157:H7 str. EDL933 integrase of prophage CP-933X NP_287351.1 1702185 R 155864 CDS NP_287352.1 15801335 959823 complement(1703317..1703553) 1 NC_002655.2 integrase of prophage CP-933X 1703553 959823 Z1867 Escherichia coli O157:H7 str. EDL933 integrase of prophage CP-933X NP_287352.1 1703317 R 155864 CDS NP_287353.1 15801336 959824 1703657..1704400 1 NC_002655.2 replication protein O of prophage CP-933X 1704400 959824 Z1868 Escherichia coli O157:H7 str. EDL933 replication protein O of prophage CP-933X NP_287353.1 1703657 D 155864 CDS NP_287354.1 15801337 959825 1704516..1705181 1 NC_002655.2 replication protein P of prophage CP-933X 1705181 959825 Z1869 Escherichia coli O157:H7 str. EDL933 replication protein P of prophage CP-933X NP_287354.1 1704516 D 155864 CDS NP_287355.1 15801338 959826 1705548..1705880 1 NC_002655.2 member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation; multidrug efflux protein 1705880 emrE 959826 emrE Escherichia coli O157:H7 str. EDL933 multidrug efflux protein NP_287355.1 1705548 D 155864 CDS NP_287356.1 15801339 959827 1706125..1707651 1 NC_002655.2 hypothetical protein 1707651 959827 Z1871 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287356.1 1706125 D 155864 CDS NP_287357.1 15801340 959828 1708153..1708608 1 NC_002655.2 DLP12 prophage; hypothetical protein 1708608 ybcN 959828 ybcN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287357.1 1708153 D 155864 CDS NP_287358.1 15801341 959829 1709058..1709420 1 NC_002655.2 DLP12 prophage; Holliday junction resolvase; endodeoxyribonuclease RUS 1709420 rus 959829 rus Escherichia coli O157:H7 str. EDL933 endodeoxyribonuclease RUS NP_287358.1 1709058 D 155864 CDS NP_287359.1 15801342 959830 1709554..1710243 1 NC_002655.2 antiterminator Q of prophage CP-933X 1710243 959830 Z1874 Escherichia coli O157:H7 str. EDL933 antiterminator Q of prophage CP-933X NP_287359.1 1709554 D 155864 CDS NP_287360.1 15801343 959831 1710565..1710870 1 NC_002655.2 holin protein of prophage CP-933X 1710870 959831 Z1875 Escherichia coli O157:H7 str. EDL933 holin protein of prophage CP-933X NP_287360.1 1710565 D 155864 CDS NP_287361.1 15801344 959832 1710857..1711333 1 NC_002655.2 endolysin of prophage CP-933X 1711333 959832 Z1876 Escherichia coli O157:H7 str. EDL933 endolysin of prophage CP-933X NP_287361.1 1710857 D 155864 CDS NP_287362.1 15801345 959833 1711474..1711791 1 NC_002655.2 endopeptidase of prophage CP-933X 1711791 959833 Z1877 Escherichia coli O157:H7 str. EDL933 endopeptidase of prophage CP-933X NP_287362.1 1711474 D 155864 CDS NP_287363.1 15801346 959834 complement(1711823..1712116) 1 NC_002655.2 Bor protein of prophage CP-933X 1712116 959834 Z1878 Escherichia coli O157:H7 str. EDL933 Bor protein of prophage CP-933X NP_287363.1 1711823 R 155864 CDS NP_287364.1 15801347 959835 complement(1712408..1712860) 1 NC_002655.2 envelope protein of prophage CP-933X 1712860 959835 Z1879 Escherichia coli O157:H7 str. EDL933 envelope protein of prophage CP-933X NP_287364.1 1712408 R 155864 CDS NP_287365.1 15801348 959836 1713104..1713310 1 NC_002655.2 hypothetical protein 1713310 959836 Z1880 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287365.1 1713104 D 155864 CDS NP_287366.1 15801349 959837 complement(1713475..1713669) 1 NC_002655.2 hypothetical protein 1713669 959837 Z1881 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287366.1 1713475 R 155864 CDS NP_287367.1 15801350 959838 1714058..1714603 1 NC_002655.2 DNA packaging protein of prophage CP-933X 1714603 959838 Z1882 Escherichia coli O157:H7 str. EDL933 DNA packaging protein of prophage CP-933X NP_287367.1 1714058 D 155864 CDS NP_287368.1 15801351 959839 1714578..1716503 1 NC_002655.2 DNA packaging protein of prophage CP-933X 1716503 959839 Z1883 Escherichia coli O157:H7 str. EDL933 DNA packaging protein of prophage CP-933X NP_287368.1 1714578 D 155864 CDS NP_287369.1 15801352 959840 1716551..1716706 1 NC_002655.2 head-tail joining protein of prophage CP-933X 1716706 959840 Z1884 Escherichia coli O157:H7 str. EDL933 head-tail joining protein of prophage CP-933X NP_287369.1 1716551 D 155864 CDS NP_287370.1 15801353 959841 1716703..1718304 1 NC_002655.2 capsid structural protein of prophage CP-933X 1718304 959841 Z1885 Escherichia coli O157:H7 str. EDL933 capsid structural protein of prophage CP-933X NP_287370.1 1716703 D 155864 CDS NP_287371.1 15801354 959843 1718285..1719604 1 NC_002655.2 capsid protein of prophage CP-933X 1719604 959843 Z1886 Escherichia coli O157:H7 str. EDL933 capsid protein of prophage CP-933X NP_287371.1 1718285 D 155864 CDS NP_287372.2 157267358 959844 1719608..>1719952 1 NC_002655.2 head-DNA stabilization protein of prophage CP-933X >1719952 959844 Z1887 Escherichia coli O157:H7 str. EDL933 head-DNA stabilization protein of prophage CP-933X NP_287372.2 1719608 D 155864 CDS NP_287373.1 15801356 959845 1720003..1721028 1 NC_002655.2 capsid protein of prophage CP-933X 1721028 959845 Z1888 Escherichia coli O157:H7 str. EDL933 capsid protein of prophage CP-933X NP_287373.1 1720003 D 155864 CDS NP_287374.1 15801357 959846 1721031..1721468 1 NC_002655.2 DNA packaging protein of prophage CP-933X 1721468 959846 Z1889 Escherichia coli O157:H7 str. EDL933 DNA packaging protein of prophage CP-933X NP_287374.1 1721031 D 155864 CDS NP_287375.1 15801358 959847 1721480..1721833 1 NC_002655.2 head-tail joining protein of prophage CP-933X 1721833 959847 Z1890 Escherichia coli O157:H7 str. EDL933 head-tail joining protein of prophage CP-933X NP_287375.1 1721480 D 155864 CDS NP_287376.1 15801359 959848 1722178..1722423 1 NC_002655.2 tail component of prophage CP-933X 1722423 959848 Z1891 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933X NP_287376.1 1722178 D 155864 CDS NP_287377.1 15801360 959849 1722420..1722815 1 NC_002655.2 tail component of prophage CP-933X 1722815 959849 Z1893 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933X NP_287377.1 1722420 D 155864 CDS NP_287378.1 15801361 959850 1722793..1723563 1 NC_002655.2 tail component of prophage CP-933X 1723563 959850 Z1894 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933X NP_287378.1 1722793 D 155864 CDS NP_287379.1 15801362 959851 1723579..1724001 1 NC_002655.2 tail component of prophage CP-933X 1724001 959851 Z1895 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933X NP_287379.1 1723579 D 155864 CDS NP_287380.1 15801363 959852 1723983..1724417 1 NC_002655.2 tail component of prophage CP-933X 1724417 959852 Z1896 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933X NP_287380.1 1723983 D 155864 CDS NP_287381.1 15801364 959853 1724410..>1725748 1 NC_002655.2 tail component of prophage CP-933X >1725748 959853 Z1898 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933X NP_287381.1 1724410 D 155864 CDS NP_287382.1 15801365 959854 1730065..1730391 1 NC_002655.2 No significant matches; hypothetical protein 1730391 959854 Z1901 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287382.1 1730065 D 155864 CDS NP_287383.1 15801366 959855 1730401..1730751 1 NC_002655.2 head-tail adaptor of prophage CP-933X 1730751 959855 Z1902 Escherichia coli O157:H7 str. EDL933 head-tail adaptor of prophage CP-933X NP_287383.1 1730401 D 155864 CDS NP_287384.1 15801367 959856 1730748..1730993 1 NC_002655.2 hypothetical protein 1730993 959856 Z1903 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287384.1 1730748 D 155864 CDS NP_287385.1 15801368 959857 1730929..1731195 1 NC_002655.2 hypothetical protein 1731195 959857 Z1905 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287385.1 1730929 D 155864 CDS NP_287386.1 15801369 959858 1731192..1731536 1 NC_002655.2 hypothetical protein 1731536 959858 Z1906 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287386.1 1731192 D 155864 CDS NP_287387.1 15801370 959859 1731533..1732321 1 NC_002655.2 tail component of prophage CP-933X 1732321 959859 Z1908 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933X NP_287387.1 1731533 D 155864 CDS NP_287388.1 15801371 959860 1732327..1732569 1 NC_002655.2 hypothetical protein 1732569 959860 Z1910 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287388.1 1732327 D 155864 CDS NP_287389.1 15801372 959861 1732727..1733008 1 NC_002655.2 hypothetical protein 1733008 959861 Z1912 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287389.1 1732727 D 155864 CDS NP_287390.1 15801373 959862 1733056..1736136 1 NC_002655.2 tail component of prophage CP-933X 1736136 959862 Z1913 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933X NP_287390.1 1733056 D 155864 CDS NP_287391.1 15801374 959863 1736470..1736907 1 NC_002655.2 minor tail fiber protein of prophage CP-933X 1736907 959863 Z1914 Escherichia coli O157:H7 str. EDL933 minor tail fiber protein of prophage CP-933X NP_287391.1 1736470 D 155864 CDS NP_287392.1 15801375 959864 1737105..1738271 1 NC_002655.2 tail protein (partial) of prophage CP-933X 1738271 959864 Z1915 Escherichia coli O157:H7 str. EDL933 tail protein (partial) of prophage CP-933X NP_287392.1 1737105 D 155864 CDS NP_287393.1 15801376 959865 1738220..1740568 1 NC_002655.2 tail protein (partial) of prophage CP-933X 1740568 959865 Z1916 Escherichia coli O157:H7 str. EDL933 tail protein (partial) of prophage CP-933X NP_287393.1 1738220 D 155864 CDS NP_287394.1 15801377 959866 1740636..1741235 1 NC_002655.2 prophage protein 1741235 959866 Z1917 Escherichia coli O157:H7 str. EDL933 prophage protein NP_287394.1 1740636 D 155864 CDS NP_287395.1 15801378 959867 1741294..1744215 1 NC_002655.2 membrane protein of prophage CP-933X 1744215 959867 Z1918 Escherichia coli O157:H7 str. EDL933 membrane protein of prophage CP-933X NP_287395.1 1741294 D 155864 CDS NP_287396.1 15801379 959869 complement(1741797..1742546) 1 NC_002655.2 hypothetical protein 1742546 959869 Z1919 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287396.1 1741797 R 155864 CDS NP_287397.1 15801380 959870 1744215..1744796 1 NC_002655.2 tail fiber protein of prophage CP-933X 1744796 959870 Z1920 Escherichia coli O157:H7 str. EDL933 tail fiber protein of prophage CP-933X NP_287397.1 1744215 D 155864 CDS NP_287398.1 15801381 959871 complement(1744916..1745806) 1 NC_002655.2 hypothetical protein 1745806 959871 Z1921 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287398.1 1744916 R 155864 CDS NP_287399.1 15801382 959872 complement(1745825..1746331) 1 NC_002655.2 hypothetical protein 1746331 959872 Z1922 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287399.1 1745825 R 155864 CDS NP_287400.1 15801383 959873 complement(1746368..1746874) 1 NC_002655.2 hypothetical protein 1746874 959873 Z1923 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287400.1 1746368 R 155864 CDS NP_287401.1 15801384 959874 complement(1746947..1747129) 1 NC_002655.2 hypothetical protein 1747129 959874 Z1924 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287401.1 1746947 R 155864 CDS NP_287402.1 15801385 959875 complement(1747627..1748295) 1 NC_002655.2 hypothetical protein 1748295 959875 Z1925 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287402.1 1747627 R 155864 CDS NP_287403.1 15801386 959876 1748352..1748600 1 NC_002655.2 hypothetical protein 1748600 959876 Z1926 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287403.1 1748352 D 155864 CDS NP_287404.1 15801387 959877 1748655..1749113 1 NC_002655.2 hypothetical protein 1749113 959877 Z1927 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287404.1 1748655 D 155864 CDS NP_287405.1 15801388 959878 1749317..1749409 1 NC_002655.2 hypothetical protein 1749409 959878 Z1928 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287405.1 1749317 D 155864 CDS NP_287406.1 15801389 959879 1749459..1750997 1 NC_002655.2 hypothetical protein 1750997 959879 Z1929 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287406.1 1749459 D 155864 CDS NP_287407.1 15801390 959880 complement(1751300..1752784) 1 NC_002655.2 protease encoded within prophage CP-933X 1752784 959880 Z1930 Escherichia coli O157:H7 str. EDL933 protease encoded within prophage CP-933X NP_287407.1 1751300 R 155864 CDS NP_287408.1 15801391 959882 complement(1752971..1753924) 1 NC_002655.2 outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA; outer membrane protease 1753924 959882 Z1931 Escherichia coli O157:H7 str. EDL933 outer membrane protease NP_287408.1 1752971 R 155864 CDS NP_287409.1 15801392 959883 1754406..1754741 1 NC_002655.2 hypothetical protein 1754741 959883 Z1932 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287409.1 1754406 D 155864 CDS NP_287410.1 15801393 959884 1754793..1755119 1 NC_002655.2 hypothetical protein 1755119 959884 Z1933 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287410.1 1754793 D 155864 CDS NP_287411.1 15801394 959885 1755359..1756006 1 NC_002655.2 transposase for IS629 1756006 959885 Z1934 Escherichia coli O157:H7 str. EDL933 transposase for IS629 NP_287411.1 1755359 D 155864 CDS NP_287412.1 15801395 959886 1756588..1756800 1 NC_002655.2 hypothetical protein 1756800 959886 Z1935 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287412.1 1756588 D 155864 CDS NP_287413.1 15801396 959887 complement(1757172..1757438) 1 NC_002655.2 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE 1757438 minE 959887 minE Escherichia coli O157:H7 str. EDL933 cell division topological specificity factor MinE NP_287413.1 1757172 R 155864 CDS NP_287414.1 15801397 959888 complement(1757442..1758254) 1 NC_002655.2 ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums; cell division inhibitor MinD 1758254 minD 959888 minD Escherichia coli O157:H7 str. EDL933 cell division inhibitor MinD NP_287414.1 1757442 R 155864 CDS NP_287415.1 15801398 959889 complement(1758278..1758973) 1 NC_002655.2 blocks the formation of polar Z-ring septums; septum formation inhibitor 1758973 minC 959889 minC Escherichia coli O157:H7 str. EDL933 septum formation inhibitor NP_287415.1 1758278 R 155864 CDS NP_287416.1 15801399 959890 1759493..1759861 1 NC_002655.2 hypothetical protein 1759861 ycgJ 959890 ycgJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287416.1 1759493 D 155864 CDS NP_287417.1 15801400 959891 complement(1759964..1760365) 1 NC_002655.2 hypothetical protein 1760365 ycgK 959891 ycgK Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287417.1 1759964 R 155864 CDS NP_287418.1 15801401 959892 1760574..1760900 1 NC_002655.2 hypothetical protein 1760900 ycgL 959892 ycgL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287418.1 1760574 D 155864 CDS NP_287419.1 15801402 959893 1760972..1761631 1 NC_002655.2 hypothetical protein 1761631 959893 Z1942 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287419.1 1760972 D 155864 CDS NP_287420.2 161367615 959894 1761723..1762169 1 NC_002655.2 hypothetical protein 1762169 ycgN 959894 ycgN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287420.2 1761723 D 155864 CDS NP_287421.1 15801404 959895 complement(1762376..1763293) 1 NC_002655.2 Acts by forming a pore-like structure upon contact with mammalian cells; hemolysin E 1763293 hlyE 959895 hlyE Escherichia coli O157:H7 str. EDL933 hemolysin E NP_287421.1 1762376 R 155864 CDS NP_287422.1 15801405 959896 1763660..1764079 1 NC_002655.2 binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuD 1764079 umuD 959896 umuD Escherichia coli O157:H7 str. EDL933 DNA polymerase V subunit UmuD NP_287422.1 1763660 D 155864 CDS NP_287423.1 15801406 959897 1764079..1765347 1 NC_002655.2 binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuC 1765347 umuC 959897 umuC Escherichia coli O157:H7 str. EDL933 DNA polymerase V subunit UmuC NP_287423.1 1764079 D 155864 CDS NP_287424.1 15801407 959898 complement(1765393..1765923) 1 NC_002655.2 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B 1765923 dsbB 959898 dsbB Escherichia coli O157:H7 str. EDL933 disulfide bond formation protein B NP_287424.1 1765393 R 155864 CDS NP_287425.1 15801408 959899 complement(1766069..1767610) 1 NC_002655.2 involved in regulation of intracellular pH under alkaline conditions; sodium/proton antiporter 1767610 nhaB 959899 nhaB Escherichia coli O157:H7 str. EDL933 sodium/proton antiporter NP_287425.1 1766069 R 155864 CDS NP_287426.1 15801409 959900 1767832..1768551 1 NC_002655.2 Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator 1768551 fadR 959900 fadR Escherichia coli O157:H7 str. EDL933 fatty acid metabolism regulator NP_287426.1 1767832 D 155864 CDS NP_287427.1 15801410 959901 complement(1768603..1770135) 1 NC_002655.2 SpoVR family protein 1770135 ycgB 959901 ycgB Escherichia coli O157:H7 str. EDL933 SpoVR family protein NP_287427.1 1768603 R 155864 CDS NP_287428.1 15801411 960218 1770498..1771796 1 NC_002655.2 catalyzes the oxidative deamination of D-amino acids; D-amino acid dehydrogenase small subunit 1771796 dadA 960218 dadA Escherichia coli O157:H7 str. EDL933 D-amino acid dehydrogenase small subunit NP_287428.1 1770498 D 155864 CDS NP_287429.1 15801412 960219 1771806..1772876 1 NC_002655.2 catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA; alanine racemase 1772876 dadX 960219 dadX Escherichia coli O157:H7 str. EDL933 alanine racemase NP_287429.1 1771806 D 155864 CDS NP_287430.2 161367614 960225 complement(1773268..1775004) 1 NC_002655.2 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli; potassium/proton antiporter 1775004 960225 Z1954 Escherichia coli O157:H7 str. EDL933 potassium/proton antiporter NP_287430.2 1773268 R 155864 CDS NP_287431.1 15801414 960229 complement(1775100..1776014) 1 NC_002655.2 catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine; L,D-carboxypeptidase A 1776014 ldcA 960229 ldcA Escherichia coli O157:H7 str. EDL933 L,D-carboxypeptidase A NP_287431.1 1775100 R 155864 CDS NP_287432.1 15801415 960231 1776000..1776725 1 NC_002655.2 murein transglycosylase E 1776725 mltE 960231 mltE Escherichia coli O157:H7 str. EDL933 murein transglycosylase E NP_287432.1 1776000 D 155864 CDS NP_287433.1 15801416 960242 complement(1776913..1777803) 1 NC_002655.2 transposase for IS629 1777803 960242 Z1957 Escherichia coli O157:H7 str. EDL933 transposase for IS629 NP_287433.1 1776913 R 155864 CDS NP_287434.1 15801417 960334 complement(1777800..1778126) 1 NC_002655.2 hypothetical protein 1778126 960334 Z1958 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287434.1 1777800 R 155864 CDS NP_287435.1 15801418 960358 complement(1778178..1778774) 1 NC_002655.2 hypothetical protein 1778774 ycgR 960358 ycgR Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287435.1 1778178 R 155864 CDS NP_287436.1 15801419 960379 1778975..1779229 1 NC_002655.2 hypothetical protein 1779229 ymgE 960379 ymgE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287436.1 1778975 D 155864 CDS NP_287437.1 15801420 960384 complement(1779279..1781249) 1 NC_002655.2 TonB dependent outer membrane receptor 1781249 prrA 960384 prrA Escherichia coli O157:H7 str. EDL933 TonB dependent outer membrane receptor NP_287437.1 1779279 R 155864 CDS NP_287438.1 15801421 960430 complement(1781275..1782129) 1 NC_002655.2 involved in molybdenum transport; molybdenum transport protein ModD 1782129 modD 960430 modD Escherichia coli O157:H7 str. EDL933 molybdenum transport protein ModD NP_287438.1 1781275 R 155864 CDS NP_287439.1 15801422 960437 complement(1782294..1782938) 1 NC_002655.2 hypothetical protein 1782938 960437 Z1963 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287439.1 1782294 R 155864 CDS NP_287440.1 15801423 960440 complement(1782948..1783706) 1 NC_002655.2 iron ABC transporter ATP-binding protein 1783706 960440 Z1964 Escherichia coli O157:H7 str. EDL933 iron ABC transporter ATP-binding protein NP_287440.1 1782948 R 155864 CDS NP_287441.1 15801424 960443 complement(1783703..1784683) 1 NC_002655.2 iron ABC transporter permease 1784683 960443 Z1965 Escherichia coli O157:H7 str. EDL933 iron ABC transporter permease NP_287441.1 1783703 R 155864 CDS NP_287442.1 15801425 960444 complement(1784683..1785705) 1 NC_002655.2 hypothetical protein 1785705 960444 Z1966 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287442.1 1784683 R 155864 CDS NP_287443.1 15801426 960445 complement(1785813..1786013) 1 NC_002655.2 No significant matches; hypothetical protein 1786013 960445 Z1967 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287443.1 1785813 R 155864 CDS NP_287444.1 15801427 960446 complement(1786041..1787498) 1 NC_002655.2 trehalase, periplasmic 1787498 treA 960446 treA Escherichia coli O157:H7 str. EDL933 trehalase, periplasmic NP_287444.1 1786041 R 155864 CDS NP_287445.1 15801428 960447 complement(1788045..1789466) 1 NC_002655.2 phosphotransferaese subunit; phosphorylates dihydroxyacetone along with DhaK/DhaL; dihydroxyacetone kinase subunit DhaM 1789466 ycgC 960447 ycgC Escherichia coli O157:H7 str. EDL933 dihydroxyacetone kinase subunit DhaM NP_287445.1 1788045 R 155864 CDS NP_287446.1 15801429 960449 complement(1789474..1790106) 1 NC_002655.2 with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone; dihydroxyacetone kinase subunit DhaL 1790106 960449 Z1970 Escherichia coli O157:H7 str. EDL933 dihydroxyacetone kinase subunit DhaL NP_287446.1 1789474 R 155864 CDS NP_287447.1 15801430 960450 complement(1790117..1791217) 1 NC_002655.2 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK 1791217 960450 Z1971 Escherichia coli O157:H7 str. EDL933 dihydroxyacetone kinase subunit DhaK NP_287447.1 1790117 R 155864 CDS NP_287448.1 15801431 960451 complement(1791522..1793165) 1 NC_002655.2 adhesion protein 1793165 960451 Z1972 Escherichia coli O157:H7 str. EDL933 adhesion protein NP_287448.1 1791522 R 155864 CDS NP_287449.1 15801432 960453 complement(1794009..1795100) 1 NC_002655.2 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 1795100 ychF 960453 ychF Escherichia coli O157:H7 str. EDL933 GTP-dependent nucleic acid-binding protein EngD NP_287449.1 1794009 R 155864 CDS NP_287450.1 15801433 960454 complement(1795217..1795801) 1 NC_002655.2 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 1795801 pth 960454 pth Escherichia coli O157:H7 str. EDL933 peptidyl-tRNA hydrolase NP_287450.1 1795217 R 155864 CDS NP_287451.1 15801434 960455 1796079..1796357 1 NC_002655.2 YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function; hypothetical protein 1796357 ychH 960455 ychH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287451.1 1796079 D 155864 CDS NP_287452.1 15801435 960456 complement(1796412..1798064) 1 NC_002655.2 role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport; sulfate transporter YchM 1798064 ychM 960456 ychM Escherichia coli O157:H7 str. EDL933 sulfate transporter YchM NP_287452.1 1796412 R 155864 CDS NP_287453.1 15801436 960457 complement(1798216..1799163) 1 NC_002655.2 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 1799163 prsA 960457 prsA Escherichia coli O157:H7 str. EDL933 ribose-phosphate pyrophosphokinase NP_287453.1 1798216 R 155864 CDS NP_287454.1 15801437 960458 complement(1799314..1800165) 1 NC_002655.2 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 1800165 ipk 960458 ipk Escherichia coli O157:H7 str. EDL933 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase NP_287454.1 1799314 R 155864 CDS NP_287455.1 15801438 960459 complement(1800165..1800788) 1 NC_002655.2 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; molecular chaperone LolB 1800788 lolB 960459 lolB Escherichia coli O157:H7 str. EDL933 molecular chaperone LolB NP_287455.1 1800165 R 155864 CDS NP_287456.1 15801439 960460 1801002..1802258 1 NC_002655.2 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 1802258 hemA 960460 hemA Escherichia coli O157:H7 str. EDL933 glutamyl-tRNA reductase NP_287456.1 1801002 D 155864 CDS NP_287457.1 15801440 960461 1802300..1803382 1 NC_002655.2 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1803382 prfA 960461 prfA Escherichia coli O157:H7 str. EDL933 peptide chain release factor 1 NP_287457.1 1802300 D 155864 CDS NP_287458.1 15801441 960462 1803382..1804215 1 NC_002655.2 HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1804215 hemK 960462 hemK Escherichia coli O157:H7 str. EDL933 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase NP_287458.1 1803382 D 155864 CDS NP_287459.1 15801442 960463 1804212..1804604 1 NC_002655.2 transcriptional regulator 1804604 960463 Z1984 Escherichia coli O157:H7 str. EDL933 transcriptional regulator NP_287459.1 1804212 D 155864 CDS NP_287460.1 15801443 960464 1804608..1805417 1 NC_002655.2 transcriptional regulator 1805417 ychA 960464 ychA Escherichia coli O157:H7 str. EDL933 transcriptional regulator NP_287460.1 1804608 D 155864 CDS NP_287461.1 15801444 960465 1805453..1806307 1 NC_002655.2 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1806307 kdsA 960465 kdsA Escherichia coli O157:H7 str. EDL933 2-dehydro-3-deoxyphosphooctonate aldolase NP_287461.1 1805453 D 155864 CDS NP_287462.1 15801445 960466 complement(1806455..1806589) 1 NC_002655.2 No significant matches; hypothetical protein 1806589 960466 Z1987 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287462.1 1806455 R 155864 CDS NP_287463.1 15801446 960467 complement(1806991..1807125) 1 NC_002655.2 No significant matches; hypothetical protein 1807125 960467 Z1989 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287463.1 1806991 R 155864 CDS NP_287464.1 15801447 960468 complement(1808027..1809127) 1 NC_002655.2 calcium/sodium:proton antiporter 1809127 chaA 960468 chaA Escherichia coli O157:H7 str. EDL933 calcium/sodium:proton antiporter NP_287464.1 1808027 R 155864 CDS NP_287465.1 15801448 960469 1809397..1809627 1 NC_002655.2 in Escherichia coli this protein ly regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions; cation transport regulator 1809627 chaB 960469 chaB Escherichia coli O157:H7 str. EDL933 cation transport regulator NP_287465.1 1809397 D 155864 CDS NP_287466.1 15801449 960470 1809788..1810483 1 NC_002655.2 cation transport regulator 1810483 chaC 960470 chaC Escherichia coli O157:H7 str. EDL933 cation transport regulator NP_287466.1 1809788 D 155864 CDS NP_287467.1 15801450 960471 complement(1810527..1810880) 1 NC_002655.2 hypothetical protein 1810880 ychN 960471 ychN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287467.1 1810527 R 155864 CDS NP_287468.1 15801451 960472 1811207..1812460 1 NC_002655.2 hypothetical protein 1812460 ychP 960472 ychP Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287468.1 1811207 D 155864 CDS NP_287469.1 15801452 960473 complement(1812461..1813111) 1 NC_002655.2 two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase; transcriptional regulator NarL 1813111 narL 960473 narL Escherichia coli O157:H7 str. EDL933 transcriptional regulator NarL NP_287469.1 1812461 R 155864 CDS NP_287470.1 15801453 960474 complement(1813104..1814900) 1 NC_002655.2 nitrate/nitrite sensor protein NarX 1814900 narX 960474 narX Escherichia coli O157:H7 str. EDL933 nitrate/nitrite sensor protein NarX NP_287470.1 1813104 R 155864 CDS NP_287471.1 15801454 960475 1815239..1816630 1 NC_002655.2 nitrite extrusion protein 1816630 narK 960475 narK Escherichia coli O157:H7 str. EDL933 nitrite extrusion protein NP_287471.1 1815239 D 155864 CDS NP_287472.1 15801455 960477 1817023..1820766 1 NC_002655.2 nitrate reductase 1 subunit alpha 1820766 narG 960477 narG Escherichia coli O157:H7 str. EDL933 nitrate reductase 1 subunit alpha NP_287472.1 1817023 D 155864 CDS NP_287473.1 15801456 960478 1820763..1822301 1 NC_002655.2 nitrate reductase 1 subunit beta 1822301 narH 960478 narH Escherichia coli O157:H7 str. EDL933 nitrate reductase 1 subunit beta NP_287473.1 1820763 D 155864 CDS NP_287474.1 15801457 960479 1822298..1823008 1 NC_002655.2 nitrate reductase 1, delta subunit, assembly function 1823008 narJ 960479 narJ Escherichia coli O157:H7 str. EDL933 nitrate reductase 1, delta subunit, assembly function NP_287474.1 1822298 D 155864 CDS NP_287475.1 15801458 960480 1823008..1823685 1 NC_002655.2 nitrate reductase 1, cytochrome b(NR), gamma subunit 1823685 narI 960480 narI Escherichia coli O157:H7 str. EDL933 nitrate reductase 1, cytochrome b(NR), gamma subunit NP_287475.1 1823008 D 155864 CDS NP_287477.1 15801460 960484 complement(1824763..1825605) 1 NC_002655.2 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase 1825605 purU 960484 purU Escherichia coli O157:H7 str. EDL933 formyltetrahydrofolate deformylase NP_287477.1 1824763 R 155864 CDS NP_287478.1 15801461 960485 complement(1825655..1826113) 1 NC_002655.2 hypothetical protein 1826113 ychJ 960485 ychJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287478.1 1825655 R 155864 CDS NP_287479.1 15801462 960486 1826187..1827131 1 NC_002655.2 hypothetical protein 1827131 ychK 960486 ychK Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287479.1 1826187 D 155864 CDS NP_287480.1 15801463 960487 1827223..1828236 1 NC_002655.2 response regulator of RpoS 1828236 hnr 960487 hnr Escherichia coli O157:H7 str. EDL933 response regulator of RpoS NP_287480.1 1827223 D 155864 CDS NP_287481.1 15801464 960488 1828438..1829346 1 NC_002655.2 together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP-glucose-1-phosphate uridylyltransferase 1829346 galU 960488 galU Escherichia coli O157:H7 str. EDL933 UTP-glucose-1-phosphate uridylyltransferase NP_287481.1 1828438 D 155864 CDS NP_287482.1 15801465 960489 complement(1829490..1829903) 1 NC_002655.2 global DNA-binding transcriptional dual regulator H-NS 1829903 hns 960489 hns Escherichia coli O157:H7 str. EDL933 global DNA-binding transcriptional dual regulator H-NS NP_287482.1 1829490 R 155864 CDS NP_287483.1 15801466 960490 1830507..1831124 1 NC_002655.2 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 1831124 tdk 960490 tdk Escherichia coli O157:H7 str. EDL933 thymidine kinase NP_287483.1 1830507 D 155864 CDS NP_287484.1 15801467 960491 complement(1831425..1834100) 1 NC_002655.2 bifunctional acetaldehyde-CoA/alcohol dehydrogenase 1834100 adhE 960491 adhE Escherichia coli O157:H7 str. EDL933 bifunctional acetaldehyde-CoA/alcohol dehydrogenase NP_287484.1 1831425 R 155864 CDS NP_287485.1 15801468 960492 1834577..1835224 1 NC_002655.2 hypothetical protein 1835224 ychE 960492 ychE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287485.1 1834577 D 155864 CDS NP_287486.1 15801469 960493 1835963..1837594 1 NC_002655.2 oligopeptide transport; periplasmic binding protein 1837594 oppA 960493 oppA Escherichia coli O157:H7 str. EDL933 oligopeptide transport; periplasmic binding protein NP_287486.1 1835963 D 155864 CDS NP_287487.1 15801470 960494 1837680..1838600 1 NC_002655.2 oligopeptide transporter permease 1838600 oppB 960494 oppB Escherichia coli O157:H7 str. EDL933 oligopeptide transporter permease NP_287487.1 1837680 D 155864 CDS NP_287488.1 15801471 960495 1838615..1839523 1 NC_002655.2 oligopeptide transport permease 1839523 oppC 960495 oppC Escherichia coli O157:H7 str. EDL933 oligopeptide transport permease NP_287488.1 1838615 D 155864 CDS NP_287489.1 15801472 960496 1839535..1840548 1 NC_002655.2 oligopeptide ABC transporter ATP-binding protein 1840548 oppD 960496 oppD Escherichia coli O157:H7 str. EDL933 oligopeptide ABC transporter ATP-binding protein NP_287489.1 1839535 D 155864 CDS NP_287490.1 15801473 960497 1840545..1841549 1 NC_002655.2 oligopeptide ABC transporter ATP-binding protein 1841549 oppF 960497 oppF Escherichia coli O157:H7 str. EDL933 oligopeptide ABC transporter ATP-binding protein NP_287490.1 1840545 D 155864 CDS NP_287491.2 161367613 960498 complement(1841602..1841931) 1 NC_002655.2 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein 1841931 960498 Z2024 Escherichia coli O157:H7 str. EDL933 dsDNA-mimic protein NP_287491.2 1841602 R 155864 CDS NP_287492.1 15801475 960499 complement(1841966..1843426) 1 NC_002655.2 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol); cardiolipin synthetase 1843426 cls 960499 cls Escherichia coli O157:H7 str. EDL933 cardiolipin synthetase NP_287492.1 1841966 R 155864 CDS NP_287493.1 15801476 960501 complement(1843798..1845051) 1 NC_002655.2 voltage-gated potassium channel 1845051 kch 960501 kch Escherichia coli O157:H7 str. EDL933 voltage-gated potassium channel NP_287493.1 1843798 R 155864 CDS NP_287494.2 161367612 960503 complement(1845352..1845648) 1 NC_002655.2 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; hypothetical protein 1845648 yciI 960503 yciI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287494.2 1845352 R 155864 CDS NP_287495.1 15801478 960504 1845873..1846592 1 NC_002655.2 membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins; transporter 1846592 tonB 960504 tonB Escherichia coli O157:H7 str. EDL933 transporter NP_287495.1 1845873 D 155864 CDS NP_287496.1 15801479 960505 complement(1846632..1847030) 1 NC_002655.2 YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase of proteins; acyl-CoA thioester hydrolase 1847030 yciA 960505 yciA Escherichia coli O157:H7 str. EDL933 acyl-CoA thioester hydrolase NP_287496.1 1846632 R 155864 CDS NP_287497.1 15801480 960506 complement(1847135..1847674) 1 NC_002655.2 Involved in cell division; probably involved in intracellular septation; intracellular septation protein A 1847674 yciB 960506 yciB Escherichia coli O157:H7 str. EDL933 intracellular septation protein A NP_287497.1 1847135 R 155864 CDS NP_287498.1 15801481 960507 complement(1847704..1848447) 1 NC_002655.2 hypothetical protein 1848447 yciC 960507 yciC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287498.1 1847704 R 155864 CDS NP_287499.1 15801482 960508 1848804..1849442 1 NC_002655.2 receptor for colicin S4; outer membrane protein W 1849442 yciD 960508 yciD Escherichia coli O157:H7 str. EDL933 outer membrane protein W NP_287499.1 1848804 D 155864 CDS NP_287500.1 15801483 960509 complement(1849488..1850618) 1 NC_002655.2 integrase for prophage CP-933O 1850618 intO 960509 intO Escherichia coli O157:H7 str. EDL933 integrase for prophage CP-933O NP_287500.1 1849488 R 155864 CDS NP_287501.1 15801484 960510 complement(1850909..1853380) 1 NC_002655.2 exonuclease VIII 1853380 exoO 960510 exoO Escherichia coli O157:H7 str. EDL933 exonuclease VIII NP_287501.1 1850909 R 155864 CDS NP_287502.1 15801485 960511 complement(1853473..1853673) 1 NC_002655.2 hypothetical protein 1853673 960511 Z2038 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287502.1 1853473 R 155864 CDS NP_287503.1 15801486 960512 complement(1853661..1853954) 1 NC_002655.2 regulator of cell division encoded by prophage CP-933O 1853954 960512 Z2039 Escherichia coli O157:H7 str. EDL933 regulator of cell division encoded by prophage CP-933O NP_287503.1 1853661 R 155864 CDS NP_287504.1 15801487 960513 1854323..1854556 1 NC_002655.2 No significant matches; hypothetical protein 1854556 960513 Z2040 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287504.1 1854323 D 155864 CDS NP_287505.1 15801488 960514 complement(1854534..1854941) 1 NC_002655.2 No significant matches; hypothetical protein 1854941 960514 Z2041 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287505.1 1854534 R 155864 CDS NP_287506.1 15801489 960515 complement(1854964..1855182) 1 NC_002655.2 hypothetical protein 1855182 960515 Z2042 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287506.1 1854964 R 155864 CDS NP_287507.1 15801490 960516 complement(1855255..1855554) 1 NC_002655.2 No significant matches; hypothetical protein 1855554 960516 Z2043 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287507.1 1855255 R 155864 CDS NP_287508.1 15801491 960517 complement(1855818..1856225) 1 NC_002655.2 The transcriptional repressor of DicA (divison cell) has a hypothetical DNA binding domain. It represses the transcription of dicB and dicC, but its specific role in cellular replication and mode of action are still unknown.; transcriptional repressor DicA 1856225 960517 Z2045 Escherichia coli O157:H7 str. EDL933 transcriptional repressor DicA NP_287508.1 1855818 R 155864 CDS NP_287509.1 15801492 960518 1856302..1856529 1 NC_002655.2 DNA-binding transcriptional regulator DicC 1856529 960518 Z2046 Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator DicC NP_287509.1 1856302 D 155864 CDS NP_287510.1 15801493 960519 1856513..1857064 1 NC_002655.2 hypothetical protein 1857064 960519 Z2047 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287510.1 1856513 D 155864 CDS NP_287511.1 15801494 960520 1857036..1858076 1 NC_002655.2 hypothetical protein 1858076 960520 Z2048 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287511.1 1857036 D 155864 CDS NP_287512.1 15801495 960521 1857865..1858530 1 NC_002655.2 hypothetical protein 1858530 960521 Z2049 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287512.1 1857865 D 155864 CDS NP_287513.1 15801496 960522 1858717..1859298 1 NC_002655.2 hypothetical protein 1859298 960522 Z2051 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287513.1 1858717 D 155864 CDS NP_287514.1 15801497 960523 1859890..1859997 1 NC_002655.2 No significant matches; hypothetical protein 1859997 960523 Z2052 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287514.1 1859890 D 155864 CDS NP_287515.1 15801498 960524 1860158..1860916 1 NC_002655.2 intestinal colonization factor encoded by prophage CP-933O 1860916 960524 Z2053 Escherichia coli O157:H7 str. EDL933 intestinal colonization factor encoded by prophage CP-933O NP_287515.1 1860158 D 155864 CDS NP_287516.1 15801499 960525 1861195..1861407 1 NC_002655.2 killer protein encoded by prophage CP-933O; paralogous proteins disrupt host membranes when produced in excess 1861407 960525 Z2054 Escherichia coli O157:H7 str. EDL933 killer protein encoded by prophage CP-933O; paralogous proteins disrupt host membranes when produced in excess NP_287516.1 1861195 D 155864 CDS NP_287517.1 15801500 960526 1861628..1861885 1 NC_002655.2 hypothetical protein 1861885 960526 Z2055 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287517.1 1861628 D 155864 CDS NP_287518.1 15801501 960527 1862299..1863282 1 NC_002655.2 hypothetical protein 1863282 960527 Z2056 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287518.1 1862299 D 155864 CDS NP_287519.1 15801502 960528 1863295..1863654 1 NC_002655.2 endonuclease of prophage CP-933O 1863654 960528 Z2057 Escherichia coli O157:H7 str. EDL933 endonuclease of prophage CP-933O NP_287519.1 1863295 D 155864 CDS NP_287520.1 15801503 960529 1863651..1864193 1 NC_002655.2 No significant matches; hypothetical protein 1864193 960529 Z2058 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287520.1 1863651 D 155864 CDS NP_287521.1 15801504 960530 1864312..1864632 1 NC_002655.2 hypothetical protein 1864632 960530 Z2059 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287521.1 1864312 D 155864 CDS NP_287522.1 15801505 960531 1864783..1865841 1 NC_002655.2 DNA adenine methyltransferase encoded by prophage CP-933O 1865841 960531 Z2060 Escherichia coli O157:H7 str. EDL933 DNA adenine methyltransferase encoded by prophage CP-933O NP_287522.1 1864783 D 155864 CDS NP_287524.1 15801507 960535 1866638..1867588 1 NC_002655.2 phage protein YjhS encoded within prophage CP-933O 1867588 960535 Z2065 Escherichia coli O157:H7 str. EDL933 phage protein YjhS encoded within prophage CP-933O NP_287524.1 1866638 D 155864 CDS NP_287525.1 15801508 960536 1867576..1868448 1 NC_002655.2 hypothetical protein 1868448 960536 Z2066 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287525.1 1867576 D 155864 CDS NP_287526.1 15801509 960537 1868303..1868491 1 NC_002655.2 No significant matches; hypothetical protein 1868491 960537 Z2068 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287526.1 1868303 D 155864 CDS NP_287527.1 15801510 960538 1868940..1869146 1 NC_002655.2 holin protein of prophage CP-933O 1869146 960538 Z2069 Escherichia coli O157:H7 str. EDL933 holin protein of prophage CP-933O NP_287527.1 1868940 D 155864 CDS NP_287528.1 15801511 960539 1869148..1869495 1 NC_002655.2 hypothetical protein 1869495 960539 Z2070 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287528.1 1869148 D 155864 CDS NP_287529.1 15801512 960540 1869546..1869776 1 NC_002655.2 endolysin of prophage CP933-O; partial 1869776 960540 Z2071 Escherichia coli O157:H7 str. EDL933 endolysin of prophage CP933-O; partial NP_287529.1 1869546 D 155864 CDS NP_287530.1 15801513 960541 1870229..1870576 1 NC_002655.2 IS encoded proteinen coded by prophage CP-933O 1870576 960541 Z2072 Escherichia coli O157:H7 str. EDL933 IS encoded proteinen coded by prophage CP-933O NP_287530.1 1870229 D 155864 CDS NP_287531.1 15801514 960542 complement(1871077..1871724) 1 NC_002655.2 transposase within CP-933O 1871724 960542 Z2073 Escherichia coli O157:H7 str. EDL933 transposase within CP-933O NP_287531.1 1871077 R 155864 CDS NP_287532.1 15801515 960543 complement(1871964..1872290) 1 NC_002655.2 IS encoded protein within CP-933O 1872290 960543 Z2074 Escherichia coli O157:H7 str. EDL933 IS encoded protein within CP-933O NP_287532.1 1871964 R 155864 CDS NP_287533.1 15801516 960544 1872625..1873119 1 NC_002655.2 hypothetical protein 1873119 960544 Z2075 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287533.1 1872625 D 155864 CDS NP_287534.1 15801517 960545 1873441..1873593 1 NC_002655.2 No significant matches; hypothetical protein 1873593 960545 Z2076 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287534.1 1873441 D 155864 CDS NP_287535.1 15801518 960546 1873867..1874514 1 NC_002655.2 hypothetical protein 1874514 960546 Z2077 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287535.1 1873867 D 155864 CDS NP_287536.1 15801519 960547 1874668..1875090 1 NC_002655.2 transposase within CP-933O 1875090 960547 Z2078 Escherichia coli O157:H7 str. EDL933 transposase within CP-933O NP_287536.1 1874668 D 155864 CDS NP_287537.1 15801520 960548 complement(1875212..1875622) 1 NC_002655.2 IS encoded protein within CP-933O 1875622 960548 Z2079 Escherichia coli O157:H7 str. EDL933 IS encoded protein within CP-933O NP_287537.1 1875212 R 155864 CDS NP_287538.1 15801521 960549 complement(1875922..1876614) 1 NC_002655.2 IS encoded protein within CP-933O 1876614 960549 Z2080 Escherichia coli O157:H7 str. EDL933 IS encoded protein within CP-933O NP_287538.1 1875922 R 155864 CDS NP_287539.1 15801522 960550 complement(1876695..1877042) 1 NC_002655.2 IS encoded protein within CP-933O 1877042 960550 Z2081 Escherichia coli O157:H7 str. EDL933 IS encoded protein within CP-933O NP_287539.1 1876695 R 155864 CDS NP_287540.1 15801523 960551 1877451..1878332 1 NC_002655.2 transposase within CP-933O; partial 1878332 960551 Z2082 Escherichia coli O157:H7 str. EDL933 transposase within CP-933O; partial NP_287540.1 1877451 D 155864 CDS NP_287541.1 15801524 960552 complement(1878382..1878717) 1 NC_002655.2 hypothetical protein 1878717 960552 Z2083 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287541.1 1878382 R 155864 CDS NP_287542.1 15801525 960553 complement(1878802..1879269) 1 NC_002655.2 integrase within CP-933O; partial 1879269 960553 Z2084 Escherichia coli O157:H7 str. EDL933 integrase within CP-933O; partial NP_287542.1 1878802 R 155864 CDS NP_287543.1 15801526 960554 complement(1879335..1880579) 1 NC_002655.2 exonuclease VIII 1880579 960554 Z2085 Escherichia coli O157:H7 str. EDL933 exonuclease VIII NP_287543.1 1879335 R 155864 CDS NP_287544.1 15801527 960555 complement(1880857..1881150) 1 NC_002655.2 division inhibition protein DicB within CP-933O 1881150 960555 Z2086 Escherichia coli O157:H7 str. EDL933 division inhibition protein DicB within CP-933O NP_287544.1 1880857 R 155864 CDS NP_287545.1 15801528 960556 complement(1881371..1881436) 1 NC_002655.2 No significant matches; hypothetical protein 1881436 960556 Z2087 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287545.1 1881371 R 155864 CDS NP_287546.1 15801529 960557 complement(1881820..1882470) 1 NC_002655.2 No significant matches; hypothetical protein 1882470 960557 Z2088 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287546.1 1881820 R 155864 CDS NP_287547.1 15801530 960558 complement(1882470..1882703) 1 NC_002655.2 hypothetical protein 1882703 960558 Z2089 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287547.1 1882470 R 155864 CDS NP_287548.1 15801531 960559 complement(1882915..1883553) 1 NC_002655.2 repressor protein encoded within prophage CP-933O 1883553 960559 Z2090 Escherichia coli O157:H7 str. EDL933 repressor protein encoded within prophage CP-933O NP_287548.1 1882915 R 155864 CDS NP_287549.1 15801532 960560 1883633..1883887 1 NC_002655.2 hypothetical protein 1883887 960560 Z2091 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287549.1 1883633 D 155864 CDS NP_287550.1 15801533 960561 1883871..1884296 1 NC_002655.2 hypothetical protein 1884296 960561 Z2092 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287550.1 1883871 D 155864 CDS NP_287551.1 15801534 960562 1884365..1885408 1 NC_002655.2 hypothetical protein 1885408 960562 Z2093 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287551.1 1884365 D 155864 CDS NP_287552.1 15801535 960563 1885200..1885862 1 NC_002655.2 hypothetical protein 1885862 960563 Z2094 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287552.1 1885200 D 155864 CDS NP_287553.1 15801536 960564 1885896..1886153 1 NC_002655.2 hypothetical protein 1886153 960564 Z2095 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287553.1 1885896 D 155864 CDS NP_287554.1 15801537 960565 1886131..1886613 1 NC_002655.2 hypothetical protein 1886613 960565 Z2096 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287554.1 1886131 D 155864 CDS NP_287555.1 15801538 960566 1887144..1887455 1 NC_002655.2 No significant matches; hypothetical protein 1887455 960566 Z2097 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287555.1 1887144 D 155864 CDS NP_287556.1 15801539 960567 1887803..1888360 1 NC_002655.2 hypothetical protein 1888360 960567 Z2098 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287556.1 1887803 D 155864 CDS NP_287557.1 15801540 960568 1888927..1889271 1 NC_002655.2 hypothetical protein 1889271 960568 Z2099 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287557.1 1888927 D 155864 CDS NP_287558.1 15801541 960569 1889668..1890717 1 NC_002655.2 hypothetical protein 1890717 960569 Z2100 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287558.1 1889668 D 155864 CDS NP_287559.1 15801542 960570 1890730..1891035 1 NC_002655.2 endonuclease encoded within prophage CP-933O 1891035 960570 Z2101 Escherichia coli O157:H7 str. EDL933 endonuclease encoded within prophage CP-933O NP_287559.1 1890730 D 155864 CDS NP_287560.1 15801543 960571 1891086..1891652 1 NC_002655.2 No significant matches; hypothetical protein 1891652 960571 Z2102 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287560.1 1891086 D 155864 CDS NP_287561.1 15801544 960572 1891790..1892074 1 NC_002655.2 hypothetical protein 1892074 960572 Z2103 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287561.1 1891790 D 155864 CDS NP_287562.1 15801545 960573 1892210..1892923 1 NC_002655.2 AraC family transcriptional regulator 1892923 960573 Z2104 Escherichia coli O157:H7 str. EDL933 AraC family transcriptional regulator NP_287562.1 1892210 D 155864 CDS NP_287563.1 15801546 960574 1893311..1893541 1 NC_002655.2 No significant matches; hypothetical protein 1893541 960574 Z2105 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287563.1 1893311 D 155864 CDS NP_287564.1 15801547 960575 1893498..1893806 1 NC_002655.2 No significant matches; hypothetical protein 1893806 960575 Z2106 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287564.1 1893498 D 155864 CDS NP_287565.1 15801548 960576 1893803..1893970 1 NC_002655.2 No significant matches; hypothetical protein 1893970 960576 Z2107 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287565.1 1893803 D 155864 CDS NP_287566.1 15801549 960577 1894381..1895331 1 NC_002655.2 phage protein YjhS encoded within prophage CP-933O 1895331 960577 Z2108 Escherichia coli O157:H7 str. EDL933 phage protein YjhS encoded within prophage CP-933O NP_287566.1 1894381 D 155864 CDS NP_287567.1 15801550 960578 1895319..1896233 1 NC_002655.2 phage protein YjhS encoded within prophage CP-933O 1896233 960578 Z2109 Escherichia coli O157:H7 str. EDL933 phage protein YjhS encoded within prophage CP-933O NP_287567.1 1895319 D 155864 CDS NP_287568.1 15801551 960580 1896409..1896735 1 NC_002655.2 transposase encoded within prophage CP-933O 1896735 960580 Z2110 Escherichia coli O157:H7 str. EDL933 transposase encoded within prophage CP-933O NP_287568.1 1896409 D 155864 CDS NP_287569.1 15801552 960581 1896975..1897622 1 NC_002655.2 transposase encoded within prophage CP-933O 1897622 960581 Z2111 Escherichia coli O157:H7 str. EDL933 transposase encoded within prophage CP-933O NP_287569.1 1896975 D 155864 CDS NP_287570.1 15801553 960582 complement(1897625..1898422) 1 NC_002655.2 ClpP-like protease encoded within prophage CP-933O 1898422 960582 Z2112 Escherichia coli O157:H7 str. EDL933 ClpP-like protease encoded within prophage CP-933O NP_287570.1 1897625 R 155864 CDS NP_287571.1 15801554 960583 complement(1898650..1899156) 1 NC_002655.2 hypothetical protein 1899156 960583 Z2113 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287571.1 1898650 R 155864 CDS NP_287572.1 15801555 960584 complement(1899500..1900006) 1 NC_002655.2 No significant matches; hypothetical protein 1900006 960584 Z2114 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287572.1 1899500 R 155864 CDS NP_287573.1 15801556 960585 complement(1900215..1900775) 1 NC_002655.2 No significant matches; hypothetical protein 1900775 960585 Z2115 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287573.1 1900215 R 155864 CDS NP_287574.1 15801557 960586 complement(1900720..1902228) 1 NC_002655.2 hypothetical protein 1902228 960586 Z2116 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287574.1 1900720 R 155864 CDS NP_287575.1 15801558 960587 complement(1902336..1902812) 1 NC_002655.2 No significant matches; hypothetical protein 1902812 960587 Z2117 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287575.1 1902336 R 155864 CDS NP_287576.1 15801559 960588 complement(1903267..1903734) 1 NC_002655.2 endopeptidase Rz of prophage CP-933O 1903734 960588 Z2118 Escherichia coli O157:H7 str. EDL933 endopeptidase Rz of prophage CP-933O NP_287576.1 1903267 R 155864 CDS NP_287577.1 15801560 960589 complement(1903736..1903888) 1 NC_002655.2 No significant matches; hypothetical protein 1903888 960589 Z2119 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287577.1 1903736 R 155864 CDS NP_287578.1 15801561 960590 complement(1904070..1904603) 1 NC_002655.2 endolysin of prophage CP-933O 1904603 960590 Z2120 Escherichia coli O157:H7 str. EDL933 endolysin of prophage CP-933O NP_287578.1 1904070 R 155864 CDS NP_287579.1 15801562 960591 1904721..1905035 1 NC_002655.2 No significant matches; hypothetical protein 1905035 960591 Z2121 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287579.1 1904721 D 155864 CDS NP_287580.1 15801563 960592 complement(1905291..1905497) 1 NC_002655.2 holin protein of prophage CP-933O 1905497 960592 Z2122 Escherichia coli O157:H7 str. EDL933 holin protein of prophage CP-933O NP_287580.1 1905291 R 155864 CDS NP_287581.1 15801564 960593 1905505..1905666 1 NC_002655.2 No significant matches; hypothetical protein 1905666 960593 Z2123 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287581.1 1905505 D 155864 CDS NP_287582.1 15801565 960594 1906248..1906523 1 NC_002655.2 No significant matches; hypothetical protein 1906523 960594 Z2124 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287582.1 1906248 D 155864 CDS NP_287583.1 15801566 960595 1906763..1907323 1 NC_002655.2 prophage CP-933O IS protein 1907323 960595 Z2127 Escherichia coli O157:H7 str. EDL933 prophage CP-933O IS protein NP_287583.1 1906763 D 155864 CDS NP_287584.1 15801567 960596 1907373..1908911 1 NC_002655.2 prophage CP-933O IS protein 1908911 960596 Z2130 Escherichia coli O157:H7 str. EDL933 prophage CP-933O IS protein NP_287584.1 1907373 D 155864 CDS NP_287585.1 15801568 960597 1909139..1911103 1 NC_002655.2 terminase large subunit of prophage CP-933O 1911103 960597 Z2131 Escherichia coli O157:H7 str. EDL933 terminase large subunit of prophage CP-933O NP_287585.1 1909139 D 155864 CDS NP_287586.1 15801569 960598 1911153..1911293 1 NC_002655.2 head completion protein of prophage CP-933O 1911293 960598 Z2132 Escherichia coli O157:H7 str. EDL933 head completion protein of prophage CP-933O NP_287586.1 1911153 D 155864 CDS NP_287587.1 15801570 960599 1911290..1912882 1 NC_002655.2 capsid assembly protein of prophage CP-933O 1912882 960599 Z2133 Escherichia coli O157:H7 str. EDL933 capsid assembly protein of prophage CP-933O NP_287587.1 1911290 D 155864 CDS NP_287588.1 15801571 960600 1912872..1914377 1 NC_002655.2 head-tail preconnector protein of prophage CP-933O 1914377 960600 Z2134 Escherichia coli O157:H7 str. EDL933 head-tail preconnector protein of prophage CP-933O NP_287588.1 1912872 D 155864 CDS NP_287589.1 15801572 960601 1914414..1914761 1 NC_002655.2 capsid protein small subunit of prophage CP-933O 1914761 960601 Z2135 Escherichia coli O157:H7 str. EDL933 capsid protein small subunit of prophage CP-933O NP_287589.1 1914414 D 155864 CDS NP_287590.1 15801573 960602 1914819..1915085 1 NC_002655.2 major capsid protein of prophage CP-933O 1915085 960602 Z2136 Escherichia coli O157:H7 str. EDL933 major capsid protein of prophage CP-933O NP_287590.1 1914819 D 155864 CDS NP_287591.1 15801574 960603 1915178..1915807 1 NC_002655.2 tail component of prophage CP-933O 1915807 960603 Z2137 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933O NP_287591.1 1915178 D 155864 CDS NP_287592.1 15801575 960604 1915749..1916252 1 NC_002655.2 tail component of prophage CP-933O 1916252 960604 Z2138 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933O NP_287592.1 1915749 D 155864 CDS NP_287593.1 15801576 960605 1916279..1916692 1 NC_002655.2 tail component of prophage CP-933O 1916692 960605 Z2139 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933O NP_287593.1 1916279 D 155864 CDS NP_287594.1 15801577 960606 1916673..1919252 1 NC_002655.2 tail component of prophage CP-933O 1919252 960606 Z2140 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933O NP_287594.1 1916673 D 155864 CDS NP_287595.1 15801578 960607 1919249..1919578 1 NC_002655.2 tail component of prophage CP-933O 1919578 960607 Z2141 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933O NP_287595.1 1919249 D 155864 CDS NP_287596.1 15801579 960608 1919578..1920276 1 NC_002655.2 tail component of prophage CP-933O 1920276 960608 Z2142 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933O NP_287596.1 1919578 D 155864 CDS NP_287597.1 15801580 960609 1920149..1921030 1 NC_002655.2 tail component of prophage CP-933O 1921030 960609 Z2143 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933O NP_287597.1 1920149 D 155864 CDS NP_287598.1 15801581 960610 1920928..1921605 1 NC_002655.2 tail component of prophage CP-933O 1921605 960610 Z2144 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933O NP_287598.1 1920928 D 155864 CDS NP_287599.1 15801582 960611 1921846..1925322 1 NC_002655.2 tail component of prophage CP-933O 1925322 960611 Z2145 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933O NP_287599.1 1921846 D 155864 CDS NP_287600.1 15801583 960612 1925390..1925989 1 NC_002655.2 outer membrane protein Lom of prophage CP-933O 1925989 960612 Z2146 Escherichia coli O157:H7 str. EDL933 outer membrane protein Lom of prophage CP-933O NP_287600.1 1925390 D 155864 CDS NP_287601.1 15801584 960613 1926048..1927367 1 NC_002655.2 tail fiber protein of prophage CP-933O 1927367 960613 Z2147 Escherichia coli O157:H7 str. EDL933 tail fiber protein of prophage CP-933O NP_287601.1 1926048 D 155864 CDS NP_287602.1 15801585 960614 1927369..1927638 1 NC_002655.2 hypothetical protein 1927638 960614 Z2148 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287602.1 1927369 D 155864 CDS NP_287603.1 15801586 960615 1927752..1928327 1 NC_002655.2 hypothetical protein 1928327 960615 Z2149 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287603.1 1927752 D 155864 CDS NP_287604.1 15801587 960616 1928400..1929029 1 NC_002655.2 hypothetical protein 1929029 960616 Z2150 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287604.1 1928400 D 155864 CDS NP_287605.1 15801588 960617 1929111..1929752 1 NC_002655.2 hypothetical protein 1929752 960617 Z2151 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287605.1 1929111 D 155864 CDS NP_287606.1 15801589 960618 complement(1929903..1930250) 1 NC_002655.2 hypothetical protein 1930250 960618 Z2152 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287606.1 1929903 R 155864 CDS NP_287607.1 15801590 960619 1930289..1931572 1 NC_002655.2 transporter 1931572 ydfJ 960619 ydfJ Escherichia coli O157:H7 str. EDL933 transporter NP_287607.1 1930289 D 155864 CDS NP_287608.1 15801591 960620 1931661..1933121 1 NC_002655.2 oxidoreductase 1933121 ydfI 960620 ydfI Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_287608.1 1931661 D 155864 CDS NP_287609.1 15801592 960621 complement(1933157..1933360) 1 NC_002655.2 hypothetical protein 1933360 960621 Z2156 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287609.1 1933157 R 155864 CDS NP_287610.1 15801593 960622 complement(1933537..1934223) 1 NC_002655.2 hypothetical protein 1934223 ydfH 960622 ydfH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287610.1 1933537 R 155864 CDS NP_287611.1 15801594 960623 complement(1934312..1935058) 1 NC_002655.2 NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine; 3-hydroxy acid dehydrogenase 1935058 ydfG 960623 ydfG Escherichia coli O157:H7 str. EDL933 3-hydroxy acid dehydrogenase NP_287611.1 1934312 R 155864 CDS NP_287612.1 15801595 960624 1935195..1937240 1 NC_002655.2 dipeptidyl carboxypeptidase II 1937240 dcp 960624 dcp Escherichia coli O157:H7 str. EDL933 dipeptidyl carboxypeptidase II NP_287612.1 1935195 D 155864 CDS NP_287613.1 15801596 960625 complement(1937285..1937803) 1 NC_002655.2 competence damage-inducible protein A 1937803 ydeJ 960625 ydeJ Escherichia coli O157:H7 str. EDL933 competence damage-inducible protein A NP_287613.1 1937285 R 155864 CDS NP_287614.1 15801597 960626 1938079..1938471 1 NC_002655.2 hypothetical protein 1938471 ydeI 960626 ydeI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287614.1 1938079 D 155864 CDS NP_287615.1 15801598 960627 1938726..1939616 1 NC_002655.2 hypothetical protein 1939616 ydeH 960627 ydeH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287615.1 1938726 D 155864 CDS NP_287616.1 15801599 960628 complement(1940038..1941021) 1 NC_002655.2 upregulated by FixLJ/FixK under oxygen limitation; involved in regulation of genes involved in carbon and amino acid metabolism; transcriptional activator FtrA 1941021 ftrA 960628 ftrA Escherichia coli O157:H7 str. EDL933 transcriptional activator FtrA NP_287616.1 1940038 R 155864 CDS NP_287617.1 15801600 960629 1941104..1941499 1 NC_002655.2 No significant matches; hypothetical protein 1941499 960629 Z2165 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287617.1 1941104 D 155864 CDS NP_287618.1 15801601 960630 complement(1941540..1942727) 1 NC_002655.2 YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters; MFS-type transporter YdeE 1942727 ydeF 960630 ydeF Escherichia coli O157:H7 str. EDL933 MFS-type transporter YdeE NP_287618.1 1941540 R 155864 CDS NP_287619.1 15801602 960631 1943021..1943821 1 NC_002655.2 O-acetylserine/cysteine export protein 1943821 ydeD 960631 ydeD Escherichia coli O157:H7 str. EDL933 O-acetylserine/cysteine export protein NP_287619.1 1943021 D 155864 CDS NP_287620.1 15801603 960632 complement(1943852..1944070) 1 NC_002655.2 hypothetical protein 1944070 marB 960632 marB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287620.1 1943852 R 155864 CDS NP_287621.2 161367611 960633 complement(1944102..1944485) 1 NC_002655.2 transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF; DNA-binding transcriptional activator MarA 1944485 marA 960633 marA Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional activator MarA NP_287621.2 1944102 R 155864 CDS NP_287622.2 161367610 960634 complement(1944505..1944939) 1 NC_002655.2 Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes; MarR family transcriptional regulator 1944939 marR 960634 marR Escherichia coli O157:H7 str. EDL933 MarR family transcriptional regulator NP_287622.2 1944505 R 155864 CDS NP_287623.1 15801606 960635 1945151..1945816 1 NC_002655.2 protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function; multiple drug resistance protein MarC 1945816 ydeB 960635 ydeB Escherichia coli O157:H7 str. EDL933 multiple drug resistance protein MarC NP_287623.1 1945151 D 155864 CDS NP_287624.1 15801607 960636 complement(1945841..1947031) 1 NC_002655.2 sugar efflux transporter 1947031 ydeA 960636 ydeA Escherichia coli O157:H7 str. EDL933 sugar efflux transporter NP_287624.1 1945841 R 155864 CDS NP_287625.1 15801608 960637 complement(1947183..1947452) 1 NC_002655.2 hypothetical protein 1947452 960637 Z2175 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287625.1 1947183 R 155864 CDS NP_287626.1 15801609 960638 complement(1947510..1948298) 1 NC_002655.2 hypothetical protein 1948298 960638 Z2176 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287626.1 1947510 R 155864 CDS NP_287627.1 15801610 960639 complement(1948376..1949257) 1 NC_002655.2 LysR family transcriptional regulator 1949257 yneJ 960639 yneJ Escherichia coli O157:H7 str. EDL933 LysR family transcriptional regulator NP_287627.1 1948376 R 155864 CDS NP_287628.1 15801611 960640 1949334..1950746 1 NC_002655.2 in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; succinate semialdehyde dehydrogenase 1950746 yneI 960640 yneI Escherichia coli O157:H7 str. EDL933 succinate semialdehyde dehydrogenase NP_287628.1 1949334 D 155864 CDS NP_287629.1 15801612 960641 1950810..1951736 1 NC_002655.2 catalyzes the formation of glutamate from glutamine; glutaminase 1951736 yneH 960641 yneH Escherichia coli O157:H7 str. EDL933 glutaminase NP_287629.1 1950810 D 155864 CDS NP_287630.1 15801613 960642 1951736..1952095 1 NC_002655.2 hypothetical protein 1952095 960642 Z2180 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287630.1 1951736 D 155864 CDS NP_287631.1 15801614 960643 1952264..1952428 1 NC_002655.2 No significant matches; hypothetical protein 1952428 960643 Z2181 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287631.1 1952264 D 155864 CDS NP_287632.1 15801615 960644 1952706..1953653 1 NC_002655.2 hypothetical protein 1953653 960644 Z2182 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287632.1 1952706 D 155864 CDS NP_287633.2 157267359 960645 1953880..1955331 1 NC_002655.2 catalyzes the formation of D-tagaturonate from D-altronate; altronate oxidoreductase 1955331 uxaB 960645 uxaB Escherichia coli O157:H7 str. EDL933 altronate oxidoreductase NP_287633.2 1953880 D 155864 CDS NP_287634.1 15801617 960646 1955477..1956442 1 NC_002655.2 hypothetical protein 1956442 960646 Z2185 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287634.1 1955477 D 155864 CDS NP_287635.1 15801618 960647 complement(1956446..1957204) 1 NC_002655.2 catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase 1957204 960647 Z2186 Escherichia coli O157:H7 str. EDL933 trans-aconitate 2-methyltransferase NP_287635.1 1956446 R 155864 CDS NP_287636.1 15801619 960648 complement(1957261..1957551) 1 NC_002655.2 autoinducer-2 (AI-2) modifying protein LsrG 1957551 960648 Z2187 Escherichia coli O157:H7 str. EDL933 autoinducer-2 (AI-2) modifying protein LsrG NP_287636.1 1957261 R 155864 CDS NP_287637.1 15801620 960649 complement(1957575..1958450) 1 NC_002655.2 aldolase 1958450 yneB 960649 yneB Escherichia coli O157:H7 str. EDL933 aldolase NP_287637.1 1957575 R 155864 CDS NP_287638.1 15801621 960650 complement(1958477..1959499) 1 NC_002655.2 LACI-type transcriptional regulator 1959499 960650 Z2189 Escherichia coli O157:H7 str. EDL933 LACI-type transcriptional regulator NP_287638.1 1958477 R 155864 CDS NP_287639.1 15801622 960651 complement(1959511..1960503) 1 NC_002655.2 transport system permease 1960503 ydeZ 960651 ydeZ Escherichia coli O157:H7 str. EDL933 transport system permease NP_287639.1 1959511 R 155864 CDS NP_287640.1 15801623 960652 complement(1960503..1961531) 1 NC_002655.2 transport system permease 1961531 ydeY 960652 ydeY Escherichia coli O157:H7 str. EDL933 transport system permease NP_287640.1 1960503 R 155864 CDS NP_287641.1 15801624 960653 complement(1961525..1963060) 1 NC_002655.2 ABC transporter ATP-binding protein 1963060 960653 Z2192 Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_287641.1 1961525 R 155864 CDS NP_287642.1 15801625 960654 1963309..1964262 1 NC_002655.2 SorC family transcriptional regulator 1964262 ydeW 960654 ydeW Escherichia coli O157:H7 str. EDL933 SorC family transcriptional regulator NP_287642.1 1963309 D 155864 CDS NP_287643.1 15801626 960655 1964341..1965933 1 NC_002655.2 autoinducer-2 (AI-2) kinase 1965933 ydeV 960655 ydeV Escherichia coli O157:H7 str. EDL933 autoinducer-2 (AI-2) kinase NP_287643.1 1964341 D 155864 CDS NP_287644.1 15801627 960656 1966464..1970495 1 NC_002655.2 lipoprotein 1970495 ydeK 960656 ydeK Escherichia coli O157:H7 str. EDL933 lipoprotein NP_287644.1 1966464 D 155864 CDS NP_287645.1 15801628 960657 1970492..1971892 1 NC_002655.2 ABC transporter ATP-binding protein 1971892 960657 Z2196 Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_287645.1 1970492 D 155864 CDS NP_287646.1 15801629 960658 1972050..1973072 1 NC_002655.2 DNA-binding regulator 1973072 hipA 960658 hipA Escherichia coli O157:H7 str. EDL933 DNA-binding regulator NP_287646.1 1972050 D 155864 CDS NP_287647.1 15801630 960659 1973409..1973612 1 NC_002655.2 hypothetical protein 1973612 960659 Z2199 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287647.1 1973409 D 155864 CDS NP_287648.1 15801631 960660 1974046..1974609 1 NC_002655.2 major fimbrial subunit 1974609 960660 Z2200 Escherichia coli O157:H7 str. EDL933 major fimbrial subunit NP_287648.1 1974046 D 155864 CDS NP_287649.1 15801632 960661 1974961..1975680 1 NC_002655.2 fimbrial chaperone protein 1975680 960661 Z2201 Escherichia coli O157:H7 str. EDL933 fimbrial chaperone protein NP_287649.1 1974961 D 155864 CDS NP_287650.1 15801633 960662 1975722..1978373 1 NC_002655.2 fimbrial usher protein 1978373 960662 Z2203 Escherichia coli O157:H7 str. EDL933 fimbrial usher protein NP_287650.1 1975722 D 155864 CDS NP_287651.1 15801634 960663 1978387..1978917 1 NC_002655.2 fimbrial-like protein 1978917 960663 Z2204 Escherichia coli O157:H7 str. EDL933 fimbrial-like protein NP_287651.1 1978387 D 155864 CDS NP_287652.1 15801635 960664 1978930..1979433 1 NC_002655.2 fimbrial-like protein 1979433 960664 Z2205 Escherichia coli O157:H7 str. EDL933 fimbrial-like protein NP_287652.1 1978930 D 155864 CDS NP_287653.1 15801636 960665 1979493..1980407 1 NC_002655.2 adhesin FimH 1980407 960665 Z2206 Escherichia coli O157:H7 str. EDL933 adhesin FimH NP_287653.1 1979493 D 155864 CDS NP_287654.1 15801637 960666 1980741..1983020 1 NC_002655.2 in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase; oxidoreductase 1983020 960666 Z2207 Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_287654.1 1980741 D 155864 CDS NP_287655.1 15801638 960667 1983268..1983465 1 NC_002655.2 hypothetical protein 1983465 960667 Z2208 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287655.1 1983268 D 155864 CDS NP_287656.1 15801639 960668 1983539..1984300 1 NC_002655.2 regulates the cellular response to acid resistance; transcriptional regulator YdeO 1984300 960668 Z2209 Escherichia coli O157:H7 str. EDL933 transcriptional regulator YdeO NP_287656.1 1983539 D 155864 CDS NP_287657.1 15801640 960669 1984671..1986386 1 NC_002655.2 sulfatase 1986386 960669 Z2210 Escherichia coli O157:H7 str. EDL933 sulfatase NP_287657.1 1984671 D 155864 CDS NP_287658.1 15801641 960670 1986423..1987595 1 NC_002655.2 hypothetical protein 1987595 960670 Z2211 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287658.1 1986423 D 155864 CDS NP_287659.1 15801642 960672 1987886..1989571 1 NC_002655.2 ABC transporter ATP-binding protein 1989571 yddA 960672 yddA Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_287659.1 1987886 D 155864 CDS NP_287660.1 15801643 960673 1989609..1991981 1 NC_002655.2 hypothetical protein 1991981 yddB 960673 yddB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287660.1 1989609 D 155864 CDS NP_287661.1 15801644 960674 1992026..1994821 1 NC_002655.2 peptidase 1994821 pqqL 960674 pqqL Escherichia coli O157:H7 str. EDL933 peptidase NP_287661.1 1992026 D 155864 CDS NP_287662.1 15801645 960675 1995182..1996582 1 NC_002655.2 glutamate decarboxylase 1996582 gadB 960675 gadB Escherichia coli O157:H7 str. EDL933 glutamate decarboxylase NP_287662.1 1995182 D 155864 CDS NP_287663.1 15801646 960676 1996738..1998273 1 NC_002655.2 acid sensitivity protein 1998273 xasA 960676 xasA Escherichia coli O157:H7 str. EDL933 acid sensitivity protein NP_287663.1 1996738 D 155864 CDS NP_287664.1 15801647 960677 1998404..1999723 1 NC_002655.2 hypothetical protein 1999723 960677 Z2217 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287664.1 1998404 D 155864 CDS NP_287665.1 15801648 960678 2000100..2001482 1 NC_002655.2 hypothetical protein 2001482 960678 Z2219 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287665.1 2000100 D 155864 CDS NP_287666.1 15805003 959622 join(2001483..2002721,2002721..2003896) 1 NC_002655.2 heme-regulated phosphodiesterase with phosphodiesterase activity with cAMP but not with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate; cAMP phosphodiesterase 2003896 959622 Z2221m Escherichia coli O157:H7 str. EDL933 cAMP phosphodiesterase NP_287666.1 2001483 D 155864 CDS NP_287667.1 15801649 960679 2004154..2004735 1 NC_002655.2 catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide: Zn dependent; involved in peptidoglycan synthesis; D-alanyl-D-alanine dipeptidase 2004735 960679 Z2222 Escherichia coli O157:H7 str. EDL933 D-alanyl-D-alanine dipeptidase NP_287667.1 2004154 D 155864 CDS NP_287668.1 15801650 960680 2004749..2006299 1 NC_002655.2 hemin-binding lipoprotein 2006299 960680 Z2223 Escherichia coli O157:H7 str. EDL933 hemin-binding lipoprotein NP_287668.1 2004749 D 155864 CDS NP_287669.1 15801651 960682 2006342..2007322 1 NC_002655.2 transport system permease 2007322 960682 Z2224 Escherichia coli O157:H7 str. EDL933 transport system permease NP_287669.1 2006342 D 155864 CDS NP_287670.1 15801652 960683 2007319..2008215 1 NC_002655.2 ATP-dependent peptide transporter membrane subunit 2008215 960683 Z2225 Escherichia coli O157:H7 str. EDL933 ATP-dependent peptide transporter membrane subunit NP_287670.1 2007319 D 155864 CDS NP_287671.1 15801653 960684 2008212..2009198 1 NC_002655.2 ABC transporter ATP-binding protein 2009198 960684 Z2226 Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_287671.1 2008212 D 155864 CDS NP_287672.1 15801654 960685 2009191..2010117 1 NC_002655.2 ABC transporter ATP-binding protein 2010117 960685 Z2227 Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_287672.1 2009191 D 155864 CDS NP_287673.1 15801655 960686 complement(2010173..2010604) 1 NC_002655.2 osmotically inducible protein 2010604 osmC 960686 osmC Escherichia coli O157:H7 str. EDL933 osmotically inducible protein NP_287673.1 2010173 R 155864 CDS NP_287674.2 161367609 960687 2010950..2011165 1 NC_002655.2 biofilm-dependent modulation protein 2011165 960687 Z2229 Escherichia coli O157:H7 str. EDL933 biofilm-dependent modulation protein NP_287674.2 2010950 D 155864 CDS NP_287675.1 15801657 960688 2011267..2011404 1 NC_002655.2 protein D; stationary-phase-induced ribosome-associated; in Escherichia coli this protein becomes associated with the ribosome; expression increases during stationary phase; 30S ribosomal subunit S22 2011404 rpsV 960688 rpsV Escherichia coli O157:H7 str. EDL933 30S ribosomal subunit S22 NP_287675.1 2011267 D 155864 CDS NP_287676.2 228979048 960690 2011561..2013258 1 NC_002655.2 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 2013258 sfcA 960690 sfcA Escherichia coli O157:H7 str. EDL933 malate dehydrogenase NP_287676.2 2011561 D 155864 CDS NP_287677.2 161367608 960692 2013392..2014402 1 NC_002655.2 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 2014402 adhP 960692 adhP Escherichia coli O157:H7 str. EDL933 alcohol dehydrogenase NP_287677.2 2013392 D 155864 CDS NP_287678.1 15801660 960694 2014470..2014832 1 NC_002655.2 hypothetical protein 2014832 yddM 960694 yddM Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287678.1 2014470 D 155864 CDS NP_287679.1 15801661 960699 complement(2015060..2015713) 1 NC_002655.2 nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase; formate dehydrogenase-N subunit gamma 2015713 fdnI 960699 fdnI Escherichia coli O157:H7 str. EDL933 formate dehydrogenase-N subunit gamma NP_287679.1 2015060 R 155864 CDS NP_287680.1 15801662 960701 complement(2015706..2016590) 1 NC_002655.2 formate dehydrogenase-N, nitrate-inducible, iron-sulfur beta subunit 2016590 fdnH 960701 fdnH Escherichia coli O157:H7 str. EDL933 formate dehydrogenase-N, nitrate-inducible, iron-sulfur beta subunit NP_287680.1 2015706 R 155864 CDS NP_287681.1 15801663 960702 complement(2016603..2019650) 1 NC_002655.2 formate dehydrogenase-N, nitrate-inducible, alpha subunit 2019650 fdnG 960702 fdnG Escherichia coli O157:H7 str. EDL933 formate dehydrogenase-N, nitrate-inducible, alpha subunit NP_287681.1 2016603 R 155864 CDS NP_287682.1 15801664 960703 2019882..2020763 1 NC_002655.2 hypothetical protein 2020763 yddG 960703 yddG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287682.1 2019882 D 155864 CDS NP_287683.1 15801665 960704 2021022..2022122 1 NC_002655.2 porin 2022122 960704 Z2239 Escherichia coli O157:H7 str. EDL933 porin NP_287683.1 2021022 D 155864 CDS NP_287684.1 15801666 960705 2022291..2022794 1 NC_002655.2 hypothetical protein 2022794 960705 Z2240 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287684.1 2022291 D 155864 CDS NP_287685.1 15801667 960706 2022917..2023549 1 NC_002655.2 hypothetical protein 2023549 960706 Z2241 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287685.1 2022917 D 155864 CDS NP_287686.1 15801668 960707 2023612..2024871 1 NC_002655.2 hypothetical protein 2024871 960707 Z2242 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287686.1 2023612 D 155864 CDS NP_287687.1 15801669 960708 2025177..2026565 1 NC_002655.2 nitrite extrusion protein 2 2026565 narU 960708 narU Escherichia coli O157:H7 str. EDL933 nitrite extrusion protein 2 NP_287687.1 2025177 D 155864 CDS NP_287688.1 15801670 960709 2026647..2030387 1 NC_002655.2 cryptic nitrate reductase 2 subunit alpha 2030387 narZ 960709 narZ Escherichia coli O157:H7 str. EDL933 cryptic nitrate reductase 2 subunit alpha NP_287688.1 2026647 D 155864 CDS NP_287689.1 15801671 960710 2030384..2031928 1 NC_002655.2 cryptic nitrate reductase 2 subunit beta 2031928 narY 960710 narY Escherichia coli O157:H7 str. EDL933 cryptic nitrate reductase 2 subunit beta NP_287689.1 2030384 D 155864 CDS NP_287690.1 15801672 960713 2031928..2032623 1 NC_002655.2 cryptic nitrate reductase 2 subunit delta 2032623 narW 960713 narW Escherichia coli O157:H7 str. EDL933 cryptic nitrate reductase 2 subunit delta NP_287690.1 2031928 D 155864 CDS NP_287691.1 15801673 960731 2032620..2033300 1 NC_002655.2 cryptic nitrate reductase 2 subunit gamma 2033300 narV 960731 narV Escherichia coli O157:H7 str. EDL933 cryptic nitrate reductase 2 subunit gamma NP_287691.1 2032620 D 155864 CDS NP_287692.1 15801674 960735 2033379..2034272 1 NC_002655.2 hypothetical protein 2034272 yddE 960735 yddE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287692.1 2033379 D 155864 CDS NP_287693.1 15801675 960739 complement(2034368..2034523) 1 NC_002655.2 hypothetical protein 2034523 960739 Z2249 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287693.1 2034368 R 155864 CDS NP_287694.1 15801676 960742 complement(2034478..2035212) 1 NC_002655.2 N-hydroxyarylamine O-acetyltransferase 2035212 960742 Z2250 Escherichia coli O157:H7 str. EDL933 N-hydroxyarylamine O-acetyltransferase NP_287694.1 2034478 R 155864 CDS NP_287695.1 15801677 960744 2035511..2035954 1 NC_002655.2 hypothetical protein 2035954 960744 Z2251 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287695.1 2035511 D 155864 CDS NP_287696.1 15801678 960745 complement(2035958..2036224) 1 NC_002655.2 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase 2036224 ydcE 960745 ydcE Escherichia coli O157:H7 str. EDL933 4-oxalocrotonate tautomerase NP_287696.1 2035958 R 155864 CDS NP_287697.1 15801679 960765 complement(2036554..2037165) 1 NC_002655.2 H repeat-containing Rhs element protein 2037165 960765 Z2253 Escherichia coli O157:H7 str. EDL933 H repeat-containing Rhs element protein NP_287697.1 2036554 R 155864 CDS NP_287698.1 15801680 960766 complement(2037265..2037444) 1 NC_002655.2 H repeat-containing Rhs element protein 2037444 960766 Z2254 Escherichia coli O157:H7 str. EDL933 H repeat-containing Rhs element protein NP_287698.1 2037265 R 155864 CDS NP_287699.1 15801681 960768 complement(2037736..2037885) 1 NC_002655.2 No significant matches; Rhs element protein 2037885 960768 Z2255 Escherichia coli O157:H7 str. EDL933 Rhs element protein NP_287699.1 2037736 R 155864 CDS NP_287700.1 15801682 960769 complement(2037952..2038161) 1 NC_002655.2 Rhs element protein 2038161 960769 Z2256 Escherichia coli O157:H7 str. EDL933 Rhs element protein NP_287700.1 2037952 R 155864 CDS NP_287701.1 15801683 960770 complement(2038358..2040328) 1 NC_002655.2 Rhs element protein 2040328 960770 Z2257 Escherichia coli O157:H7 str. EDL933 Rhs element protein NP_287701.1 2038358 R 155864 CDS NP_287702.1 15801684 960774 complement(2040412..2042130) 1 NC_002655.2 Rhs element protein 2042130 960774 Z2259 Escherichia coli O157:H7 str. EDL933 Rhs element protein NP_287702.1 2040412 R 155864 CDS NP_287703.1 15801685 960775 complement(2042057..2042560) 1 NC_002655.2 Rhs element protein 2042560 960775 Z2261 Escherichia coli O157:H7 str. EDL933 Rhs element protein NP_287703.1 2042057 R 155864 CDS NP_287704.1 15801686 960776 complement(2042627..2044771) 1 NC_002655.2 Rhs element protein 2044771 vgrE 960776 vgrE Escherichia coli O157:H7 str. EDL933 Rhs element protein NP_287704.1 2042627 R 155864 CDS NP_287705.1 15801687 960780 2044997..2045143 1 NC_002655.2 No significant matches; Rhs element protein 2045143 960780 Z2263 Escherichia coli O157:H7 str. EDL933 Rhs element protein NP_287705.1 2044997 D 155864 CDS NP_287706.1 15801688 960782 complement(2045556..2045768) 1 NC_002655.2 hypothetical protein 2045768 960782 Z2264 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287706.1 2045556 R 155864 CDS NP_287707.1 15801689 960783 complement(2045844..2046461) 1 NC_002655.2 transferase 2046461 960783 Z2265 Escherichia coli O157:H7 str. EDL933 transferase NP_287707.1 2045844 R 155864 CDS NP_287708.1 15801690 960787 2046677..2048227 1 NC_002655.2 L-asparagine permease 2048227 ansP 960787 ansP Escherichia coli O157:H7 str. EDL933 L-asparagine permease NP_287708.1 2046677 D 155864 CDS NP_287709.1 15801691 960790 complement(2048342..2049403) 1 NC_002655.2 receptor 2049403 960790 Z2267 Escherichia coli O157:H7 str. EDL933 receptor NP_287709.1 2048342 R 155864 CDS NP_287710.1 15801692 960791 2049645..2051747 1 NC_002655.2 outer membrane receptor for iron transport 2051747 960791 Z2268 Escherichia coli O157:H7 str. EDL933 outer membrane receptor for iron transport NP_287710.1 2049645 D 155864 CDS NP_287711.1 15801693 960792 complement(2051783..2052505) 1 NC_002655.2 DNA-binding transcriptional regulator 2052505 960792 Z2269 Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator NP_287711.1 2051783 R 155864 CDS NP_287712.1 15801694 960806 complement(2052646..2053776) 1 NC_002655.2 oxidoreductase 2053776 yncB 960806 yncB Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_287712.1 2052646 R 155864 CDS NP_287713.1 15801695 960808 2053864..2054382 1 NC_002655.2 resistance protein 2054382 960808 Z2271 Escherichia coli O157:H7 str. EDL933 resistance protein NP_287713.1 2053864 D 155864 CDS NP_287714.1 15801696 960812 2054379..2054828 1 NC_002655.2 hypothetical protein 2054828 960812 Z2272 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287714.1 2054379 D 155864 CDS NP_287715.1 15801697 960818 complement(2054829..2055062) 1 NC_002655.2 hypothetical protein 2055062 960818 Z2273 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287715.1 2054829 R 155864 CDS NP_287716.1 15801698 960819 complement(2055148..2055369) 1 NC_002655.2 hypothetical protein 2055369 960819 Z2274 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287716.1 2055148 R 155864 CDS NP_287717.1 15801699 960824 complement(2055708..2057132) 1 NC_002655.2 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; gamma-aminobutyraldehyde dehydrogenase 2057132 960824 Z2275 Escherichia coli O157:H7 str. EDL933 gamma-aminobutyraldehyde dehydrogenase NP_287717.1 2055708 R 155864 CDS NP_287718.1 15801700 960825 complement(2057154..2057948) 1 NC_002655.2 transport system permease 2057948 960825 Z2276 Escherichia coli O157:H7 str. EDL933 transport system permease NP_287718.1 2057154 R 155864 CDS NP_287719.1 15801701 960829 complement(2057938..2058879) 1 NC_002655.2 transport system permease 2058879 960829 Z2277 Escherichia coli O157:H7 str. EDL933 transport system permease NP_287719.1 2057938 R 155864 CDS NP_287720.1 15801702 960830 complement(2058880..2059893) 1 NC_002655.2 ABC transporter ATP-binding protein 2059893 960830 Z2278 Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_287720.1 2058880 R 155864 CDS NP_287721.1 15801703 960831 complement(2059911..2061056) 1 NC_002655.2 transporter 2061056 960831 Z2279 Escherichia coli O157:H7 str. EDL933 transporter NP_287721.1 2059911 R 155864 CDS NP_287722.1 15801704 960832 complement(2061301..2062707) 1 NC_002655.2 multifunctional transcriptional regulator/ABC transporter ATP-binding protein 2062707 960832 Z2280 Escherichia coli O157:H7 str. EDL933 multifunctional transcriptional regulator/ABC transporter ATP-binding protein NP_287722.1 2061301 R 155864 CDS NP_287723.1 15801705 960844 complement(2062786..2063223) 1 NC_002655.2 hypothetical protein 2063223 960844 Z2281 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287723.1 2062786 R 155864 CDS NP_287724.1 15801706 960899 2063263..2063460 1 NC_002655.2 hypothetical protein 2063460 960899 Z2282 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287724.1 2063263 D 155864 CDS NP_287725.1 15801707 960921 2063646..2063876 1 NC_002655.2 hypothetical protein 2063876 960921 Z2283 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287725.1 2063646 D 155864 CDS NP_287726.1 15801708 960922 complement(2063968..2065971) 1 NC_002655.2 collagenase 2065971 ydcP 960922 ydcP Escherichia coli O157:H7 str. EDL933 collagenase NP_287726.1 2063968 R 155864 CDS NP_287727.1 15801709 960929 complement(2066002..2066538) 1 NC_002655.2 hypothetical protein 2066538 ydcN 960929 ydcN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287727.1 2066002 R 155864 CDS NP_287728.1 15801710 960944 2066573..2067802 1 NC_002655.2 membrane transport protein 2067802 960944 Z2286 Escherichia coli O157:H7 str. EDL933 membrane transport protein NP_287728.1 2066573 D 155864 CDS NP_287729.1 15801711 960969 complement(2067837..2068505) 1 NC_002655.2 hypothetical protein 2068505 960969 Z2287 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287729.1 2067837 R 155864 CDS NP_287730.1 15801712 960971 complement(2068811..2069404) 1 NC_002655.2 with TehA confers resistance to tellurite; tellurite resistance protein TehB 2069404 tehB 960971 tehB Escherichia coli O157:H7 str. EDL933 tellurite resistance protein TehB NP_287730.1 2068811 R 155864 CDS NP_287731.1 15801713 960974 complement(2069401..2070393) 1 NC_002655.2 potassium-tellurite ethidium and proflavin transporter 2070393 tehA 960974 tehA Escherichia coli O157:H7 str. EDL933 potassium-tellurite ethidium and proflavin transporter NP_287731.1 2069401 R 155864 CDS NP_287732.1 15801714 960976 2070517..2071497 1 NC_002655.2 hypothetical protein 2071497 960976 Z2290 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287732.1 2070517 D 155864 CDS NP_287733.1 15801715 960977 complement(2071732..2072028) 1 NC_002655.2 hypothetical protein 2072028 960977 Z2291 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287733.1 2071732 R 155864 CDS NP_287734.1 15801716 960981 complement(2072091..2072258) 1 NC_002655.2 hypothetical protein 2072258 ydcH 960981 ydcH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287734.1 2072091 R 155864 CDS NP_287735.1 15801717 960983 2072331..2072534 1 NC_002655.2 hypothetical protein 2072534 960983 Z2293 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287735.1 2072331 D 155864 CDS NP_287736.1 15801718 960984 complement(2072455..2074110) 1 NC_002655.2 involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans; glucan biosynthesis protein D 2074110 mdoD 960984 mdoD Escherichia coli O157:H7 str. EDL933 glucan biosynthesis protein D NP_287736.1 2072455 R 155864 CDS NP_287737.1 15801719 960985 complement(2074336..2074860) 1 NC_002655.2 hypothetical protein 2074860 960985 Z2296 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287737.1 2074336 R 155864 CDS NP_287738.1 15801720 960986 complement(2074877..2075515) 1 NC_002655.2 hypothetical protein 2075515 960986 Z2297 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287738.1 2074877 R 155864 CDS NP_287739.1 15801721 960987 complement(2075484..2075681) 1 NC_002655.2 hypothetical protein 2075681 960987 Z2298 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287739.1 2075484 R 155864 CDS NP_287740.1 15801722 960988 2075757..2076821 1 NC_002655.2 LysR family transcriptional regulator 2076821 960988 Z2299 Escherichia coli O157:H7 str. EDL933 LysR family transcriptional regulator NP_287740.1 2075757 D 155864 CDS NP_287741.1 15801723 960989 complement(2076859..2078499) 1 NC_002655.2 methyl-accepting chemotaxis protein III, ribose sensor receptor 2078499 trg 960989 trg Escherichia coli O157:H7 str. EDL933 methyl-accepting chemotaxis protein III, ribose sensor receptor NP_287741.1 2076859 R 155864 CDS NP_287742.1 15801724 960990 2078840..2079007 1 NC_002655.2 hypothetical protein 2079007 960990 Z2301 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287742.1 2078840 D 155864 CDS NP_287743.1 15801725 960991 complement(2079119..2079292) 1 NC_002655.2 hypothetical protein 2079292 ydcA 960991 ydcA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287743.1 2079119 R 155864 CDS NP_287744.1 15801726 960992 complement(2079537..2080103) 1 NC_002655.2 B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm; cytochrome b561 2080103 cybB 960992 cybB Escherichia coli O157:H7 str. EDL933 cytochrome b561 NP_287744.1 2079537 R 155864 CDS NP_287745.1 15801727 960993 2080256..2081257 1 NC_002655.2 glyceraldehyde-3-phosphate dehydrogenase 2081257 gapC 960993 gapC Escherichia coli O157:H7 str. EDL933 glyceraldehyde-3-phosphate dehydrogenase NP_287745.1 2080256 D 155864 CDS NP_287746.1 15801728 960994 complement(2081299..2082738) 1 NC_002655.2 NAD-linked; aldehyde dehydrogenase 2082738 aldA 960994 aldA Escherichia coli O157:H7 str. EDL933 aldehyde dehydrogenase NP_287746.1 2081299 R 155864 CDS NP_287747.1 15801729 960995 complement(2082935..2083735) 1 NC_002655.2 hypothetical protein 2083735 ydcF 960995 ydcF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287747.1 2082935 R 155864 CDS NP_287748.1 15801730 960996 complement(2083851..2084228) 1 NC_002655.2 No significant matches; hypothetical protein 2084228 960996 Z2309 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287748.1 2083851 R 155864 CDS NP_287749.1 15801731 960997 complement(2084353..2084784) 1 NC_002655.2 No significant matches; hypothetical protein 2084784 960997 Z2310 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287749.1 2084353 R 155864 CDS NP_287750.1 15801732 960998 complement(2084771..2085139) 1 NC_002655.2 No significant matches; hypothetical protein 2085139 960998 Z2311 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287750.1 2084771 R 155864 CDS NP_287751.1 15801733 960999 complement(2085114..2085539) 1 NC_002655.2 No significant matches; hypothetical protein 2085539 960999 Z2312 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287751.1 2085114 R 155864 CDS NP_287752.1 15801734 961000 complement(2085685..2089530) 1 NC_002655.2 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA 2089530 hrpA 961000 hrpA Escherichia coli O157:H7 str. EDL933 ATP-dependent RNA helicase HrpA NP_287752.1 2085685 R 155864 CDS NP_287753.1 15801735 961001 2089788..2090393 1 NC_002655.2 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds; azoreductase 2090393 acpD 961001 acpD Escherichia coli O157:H7 str. EDL933 azoreductase NP_287753.1 2089788 D 155864 CDS NP_287754.1 15801736 961002 complement(2090444..2091736) 1 NC_002655.2 hypothetical protein 2091736 ynbD 961002 ynbD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287754.1 2090444 R 155864 CDS NP_287755.1 15801737 961003 complement(2091750..2093507) 1 NC_002655.2 hypothetical protein 2093507 961003 Z2317 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287755.1 2091750 R 155864 CDS NP_287756.1 15801738 961004 complement(2093523..2094419) 1 NC_002655.2 phosphatidate cytidylyltransferase 2094419 961004 Z2318 Escherichia coli O157:H7 str. EDL933 phosphatidate cytidylyltransferase NP_287756.1 2093523 R 155864 CDS NP_287757.1 15801739 961005 complement(2094419..2095030) 1 NC_002655.2 hypothetical protein 2095030 961005 Z2319 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287757.1 2094419 R 155864 CDS NP_287758.1 15801740 961006 complement(2095195..2097507) 1 NC_002655.2 hypothetical protein 2097507 ydbD 961006 ydbD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287758.1 2095195 R 155864 CDS NP_287759.1 15801741 961007 complement(2097565..2098425) 1 NC_002655.2 oxidoreductase 2098425 ydbC 961007 ydbC Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_287759.1 2097565 R 155864 CDS NP_287760.1 15801742 961008 complement(2098645..2101104) 1 NC_002655.2 hypothetical protein 2101104 961008 Z2322 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287760.1 2098645 R 155864 CDS NP_287761.1 15801743 961009 complement(2101324..2104044) 1 NC_002655.2 hypothetical protein 2104044 961009 Z2323 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287761.1 2101324 R 155864 CDS NP_287762.1 15801744 961010 complement(2104315..2104434) 1 NC_002655.2 No significant matches; hypothetical protein 2104434 961010 Z2325 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287762.1 2104315 R 155864 CDS NP_287763.1 15801745 961011 complement(2104774..2105103) 1 NC_002655.2 hypothetical protein 2105103 ydbL 961011 ydbL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287763.1 2104774 R 155864 CDS NP_287764.1 15801746 961012 complement(2105105..2105290) 1 NC_002655.2 hypothetical protein 2105290 ynbE 961012 ynbE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287764.1 2105105 R 155864 CDS NP_287765.1 15801747 961013 complement(2105287..2107926) 1 NC_002655.2 hypothetical protein 2107926 ydbH 961013 ydbH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287765.1 2105287 R 155864 CDS NP_287766.1 15801748 961014 2108135..2109124 1 NC_002655.2 Catalyzes the reduction of sulfopyruvate to (R)-sulfolactate much more efficiently than the reverse reaction. Also catalyzes the reduction of oxaloacetate, alpha-ketoglutarate, and to a much lower extent, KHTCA, but not pyruvate. Involved in the biosynthes; D-lactate dehydrogenase 2109124 ldhA 961014 ldhA Escherichia coli O157:H7 str. EDL933 D-lactate dehydrogenase NP_287766.1 2108135 D 155864 CDS NP_287767.1 15801749 961015 2109236..2109658 1 NC_002655.2 heat-inducible protein 2109658 hslJ 961015 hslJ Escherichia coli O157:H7 str. EDL933 heat-inducible protein NP_287767.1 2109236 D 155864 CDS NP_287768.1 15801750 961016 2110195..2113719 1 NC_002655.2 oxidoreductase, Fe-S subunit 2113719 ydbK 961016 ydbK Escherichia coli O157:H7 str. EDL933 oxidoreductase, Fe-S subunit NP_287768.1 2110195 D 155864 CDS NP_287769.1 15801751 961017 2114085..2114456 1 NC_002655.2 hypothetical protein 2114456 961017 Z2333 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287769.1 2114085 D 155864 CDS NP_287770.1 15801752 961018 2114431..2115198 1 NC_002655.2 hypothetical protein 2115198 961018 Z2334 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287770.1 2114431 D 155864 CDS NP_287771.1 15801753 961019 2115267..2115773 1 NC_002655.2 hypothetical protein 2115773 ynaF 961019 ynaF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287771.1 2115267 D 155864 CDS NP_287772.1 15801754 961020 complement(2116354..2116995) 1 NC_002655.2 hypothetical protein 2116995 961020 Z2337 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287772.1 2116354 R 155864 CDS NP_287773.1 15801755 961021 complement(2117077..2117706) 1 NC_002655.2 hypothetical protein 2117706 961021 Z2338 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287773.1 2117077 R 155864 CDS NP_287774.1 15801756 961022 complement(2117779..2118354) 1 NC_002655.2 hypothetical protein 2118354 961022 Z2339 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287774.1 2117779 R 155864 CDS NP_287775.1 15801757 961023 complement(2118738..2120057) 1 NC_002655.2 tail fiber protein encoded by prophage CP-933R 2120057 961023 Z2340 Escherichia coli O157:H7 str. EDL933 tail fiber protein encoded by prophage CP-933R NP_287775.1 2118738 R 155864 CDS NP_287776.2 315064809 961024 complement(2120116..>2120442) 1 NC_002655.2 outer membrane protein Lom encoded by prophage CP-933R >2120442 961024 Z2342 Escherichia coli O157:H7 str. EDL933 outer membrane protein Lom encoded by prophage CP-933R NP_287776.2 2120116 R 155864 CDS NP_287777.1 15801759 961025 complement(2120536..2120817) 1 NC_002655.2 outer membrane protein Lom encoded by prophage CP-933R 2120817 961025 Z2343 Escherichia coli O157:H7 str. EDL933 outer membrane protein Lom encoded by prophage CP-933R NP_287777.1 2120536 R 155864 CDS NP_287778.1 15801760 961026 complement(2120885..2123818) 1 NC_002655.2 tail fiber protein encoded by prophage CP-933R 2123818 961026 Z2344 Escherichia coli O157:H7 str. EDL933 tail fiber protein encoded by prophage CP-933R NP_287778.1 2120885 R 155864 CDS NP_287779.1 15801761 961027 complement(2123826..2124359) 1 NC_002655.2 phage tail protein encoded by prophage CP-933R 2124359 961027 Z2346 Escherichia coli O157:H7 str. EDL933 phage tail protein encoded by prophage CP-933R NP_287779.1 2123826 R 155864 CDS NP_287780.1 15801762 961030 2124196..2125020 1 NC_002655.2 copper-zinc superoxide dismutase encoded within prophage CP-933R 2125020 961030 Z2347 Escherichia coli O157:H7 str. EDL933 copper-zinc superoxide dismutase encoded within prophage CP-933R NP_287780.1 2124196 D 155864 CDS NP_287781.1 15801763 961033 complement(2125211..2125345) 1 NC_002655.2 phage tail protein encoded by prophage CP-933R 2125345 961033 Z2348 Escherichia coli O157:H7 str. EDL933 phage tail protein encoded by prophage CP-933R NP_287781.1 2125211 R 155864 CDS NP_287782.1 15801764 961034 complement(2125364..2125642) 1 NC_002655.2 phage tail protein encoded by prophage CP-933R 2125642 961034 Z2350 Escherichia coli O157:H7 str. EDL933 phage tail protein encoded by prophage CP-933R NP_287782.1 2125364 R 155864 CDS NP_287783.1 15801765 961037 complement(2125787..2126461) 1 NC_002655.2 tail component of prophage CP-933R 2126461 961037 Z2351 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933R NP_287783.1 2125787 R 155864 CDS NP_287784.1 15801766 961047 complement(2126541..2127239) 1 NC_002655.2 tail component of prophage CP-933R 2127239 961047 Z2352 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933R NP_287784.1 2126541 R 155864 CDS NP_287785.1 15801767 961050 complement(2127239..2127568) 1 NC_002655.2 tail component of prophage CP-933R 2127568 961050 Z2353 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933R NP_287785.1 2127239 R 155864 CDS NP_287786.1 15801768 961055 complement(2127565..2128329) 1 NC_002655.2 tail component of prophage CP-933R 2128329 961055 Z2354 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933R NP_287786.1 2127565 R 155864 CDS NP_287787.1 15801769 961059 complement(2128281..2130143) 1 NC_002655.2 tail component of prophage CP-933R 2130143 961059 Z2355 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933R NP_287787.1 2128281 R 155864 CDS NP_287788.1 15801770 961066 complement(2130124..2130537) 1 NC_002655.2 tail component of prophage CP-933R 2130537 961066 Z2356 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933R NP_287788.1 2130124 R 155864 CDS NP_287789.1 15801771 961078 complement(2130564..2131067) 1 NC_002655.2 tail component of prophage CP-933R 2131067 961078 Z2357 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933R NP_287789.1 2130564 R 155864 CDS NP_287790.1 15801772 961087 complement(2131009..2131671) 1 NC_002655.2 tail component of prophage CP-933R 2131671 961087 Z2358 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933R NP_287790.1 2131009 R 155864 CDS NP_287791.1 15801773 961089 complement(2131731..2131997) 1 NC_002655.2 capsid structural protein of prophage CP-933R 2131997 961089 Z2359 Escherichia coli O157:H7 str. EDL933 capsid structural protein of prophage CP-933R NP_287791.1 2131731 R 155864 CDS NP_287792.1 15801774 961096 complement(2132055..2132402) 1 NC_002655.2 capsid protein of prophage CP-933R 2132402 961096 Z2360 Escherichia coli O157:H7 str. EDL933 capsid protein of prophage CP-933R NP_287792.1 2132055 R 155864 CDS NP_287793.1 15801775 961099 complement(2132439..2133944) 1 NC_002655.2 capsid assembly protein of prophage CP-933R 2133944 961099 Z2361 Escherichia coli O157:H7 str. EDL933 capsid assembly protein of prophage CP-933R NP_287793.1 2132439 R 155864 CDS NP_287794.1 15801776 961100 complement(2133934..2135526) 1 NC_002655.2 capsid protein of prophage CP-933R 2135526 961100 Z2362 Escherichia coli O157:H7 str. EDL933 capsid protein of prophage CP-933R NP_287794.1 2133934 R 155864 CDS NP_287795.1 15801777 961101 complement(2135523..2135663) 1 NC_002655.2 DNA packaging protein of prophage CP-933R 2135663 961101 Z2363 Escherichia coli O157:H7 str. EDL933 DNA packaging protein of prophage CP-933R NP_287795.1 2135523 R 155864 CDS NP_287796.1 15801778 961103 complement(2135713..2137677) 1 NC_002655.2 DNA packaging protein of prophage CP-933R; terminase large subunit 2137677 961103 Z2364 Escherichia coli O157:H7 str. EDL933 DNA packaging protein of prophage CP-933R; terminase large subunit NP_287796.1 2135713 R 155864 CDS NP_287797.1 15801779 961104 complement(2137613..2138122) 1 NC_002655.2 DNA packaging protein of prophage CP-933R; terminase small subunit 2138122 961104 Z2365 Escherichia coli O157:H7 str. EDL933 DNA packaging protein of prophage CP-933R; terminase small subunit NP_287797.1 2137613 R 155864 CDS NP_287798.1 15801780 961105 2138517..2138741 1 NC_002655.2 hypothetical protein 2138741 961105 Z2366 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287798.1 2138517 D 155864 CDS NP_287799.1 15801781 961106 2139140..2139253 1 NC_002655.2 No significant matches; hypothetical protein 2139253 961106 Z2367 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287799.1 2139140 D 155864 CDS NP_287800.1 15801782 961108 complement(2139379..2139519) 1 NC_002655.2 No significant matches; hypothetical protein 2139519 961108 Z2368 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287800.1 2139379 R 155864 CDS NP_287801.1 15801783 961109 complement(2139602..2140069) 1 NC_002655.2 endopeptidase Rz of prophage CP-933R 2140069 961109 Z2369 Escherichia coli O157:H7 str. EDL933 endopeptidase Rz of prophage CP-933R NP_287801.1 2139602 R 155864 CDS NP_287802.1 15801784 961110 complement(2140221..2140403) 1 NC_002655.2 No significant matches; hypothetical protein 2140403 961110 Z2370 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287802.1 2140221 R 155864 CDS NP_287803.1 15801785 961111 complement(2140559..2141092) 1 NC_002655.2 lysozyme R of prophage CP-933R 2141092 961111 Z2371 Escherichia coli O157:H7 str. EDL933 lysozyme R of prophage CP-933R NP_287803.1 2140559 R 155864 CDS NP_287804.1 15801786 961113 complement(2141118..2141489) 1 NC_002655.2 hypothetical protein 2141489 961113 Z2372 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287804.1 2141118 R 155864 CDS NP_287805.1 15801787 961114 complement(2141494..2141700) 1 NC_002655.2 holin protein of prophage CP-933R 2141700 961114 Z2374 Escherichia coli O157:H7 str. EDL933 holin protein of prophage CP-933R NP_287805.1 2141494 R 155864 CDS NP_287806.1 15801788 961115 2142020..2142346 1 NC_002655.2 hypothetical protein 2142346 961115 Z2375 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287806.1 2142020 D 155864 CDS NP_287807.1 15801789 961116 2142587..2143234 1 NC_002655.2 IS629 transposase within prophage CP-933R 2143234 961116 Z2376 Escherichia coli O157:H7 str. EDL933 IS629 transposase within prophage CP-933R NP_287807.1 2142587 D 155864 CDS NP_287808.1 15801790 961117 complement(2143317..2145167) 1 NC_002655.2 hypothetical protein 2145167 961117 Z2377 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287808.1 2143317 R 155864 CDS NP_287809.1 15801791 961118 complement(2145579..2145746) 1 NC_002655.2 No significant matches; hypothetical protein 2145746 961118 Z2378 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287809.1 2145579 R 155864 CDS NP_287810.1 15801792 961119 complement(2145743..2146237) 1 NC_002655.2 hypothetical protein 2146237 961119 Z2379 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287810.1 2145743 R 155864 CDS NP_287811.1 15801793 961124 complement(2146736..2146900) 1 NC_002655.2 No significant matches; hypothetical protein 2146900 961124 Z2382 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287811.1 2146736 R 155864 CDS NP_287812.1 15801794 961125 complement(2146893..2147411) 1 NC_002655.2 No significant matches; hypothetical protein 2147411 961125 Z2384 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287812.1 2146893 R 155864 CDS NP_287813.1 15801795 961126 complement(2147578..2148177) 1 NC_002655.2 No significant matches; hypothetical protein 2148177 961126 Z2385 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287813.1 2147578 R 155864 CDS NP_287814.1 15801796 961127 2148677..2150068 1 NC_002655.2 No significant matches; hypothetical protein 2150068 961127 Z2386 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287814.1 2148677 D 155864 CDS NP_287815.1 15801797 961128 2150065..2151057 1 NC_002655.2 No significant matches; hypothetical protein 2151057 961128 Z2387 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287815.1 2150065 D 155864 CDS NP_287816.1 15801798 961129 complement(2151025..2152176) 1 NC_002655.2 DNA modification methyltransferase encoded within prophage CP-933R 2152176 961129 Z2389 Escherichia coli O157:H7 str. EDL933 DNA modification methyltransferase encoded within prophage CP-933R NP_287816.1 2151025 R 155864 CDS NP_287817.1 15801799 961130 complement(2152608..2152865) 1 NC_002655.2 hypothetical protein 2152865 961130 Z2390 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287817.1 2152608 R 155864 CDS NP_287818.1 15801800 961131 complement(2152932..2153093) 1 NC_002655.2 hypothetical protein 2153093 961131 Z2391 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287818.1 2152932 R 155864 CDS NP_287819.1 15801801 961132 complement(2153104..2153367) 1 NC_002655.2 No significant matches; hypothetical protein 2153367 961132 Z2392 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287819.1 2153104 R 155864 CDS NP_287820.1 15801802 961134 complement(2153619..2153831) 1 NC_002655.2 No significant matches; hypothetical protein 2153831 961134 Z2393 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287820.1 2153619 R 155864 CDS NP_287821.1 15801803 961136 complement(2153937..2154359) 1 NC_002655.2 No significant matches; hypothetical protein 2154359 961136 Z2394 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287821.1 2153937 R 155864 CDS NP_287822.1 15801804 961137 complement(2154375..2155187) 1 NC_002655.2 hypothetical protein 2155187 961137 Z2395 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287822.1 2154375 R 155864 CDS NP_287823.1 15801805 961138 complement(2155159..2155905) 1 NC_002655.2 acts to load the DnaB helicase onto the intiation site durning DNA replication; replication protein 2155905 961138 Z2396 Escherichia coli O157:H7 str. EDL933 replication protein NP_287823.1 2155159 R 155864 CDS NP_287824.1 15801806 961139 complement(2155912..2156700) 1 NC_002655.2 hypothetical protein 2156700 961139 Z2397 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287824.1 2155912 R 155864 CDS NP_287825.1 15801807 961140 complement(2156778..2157200) 1 NC_002655.2 hypothetical protein 2157200 961140 Z2398 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287825.1 2156778 R 155864 CDS NP_287826.1 15801808 961142 complement(2157197..2157523) 1 NC_002655.2 regulatory protein Cro of prophage CP-933R 2157523 961142 Z2399 Escherichia coli O157:H7 str. EDL933 regulatory protein Cro of prophage CP-933R NP_287826.1 2157197 R 155864 CDS NP_287827.1 15801809 961143 2157531..2157827 1 NC_002655.2 represssor protein encoded within prophage CP-933R 2157827 961143 Z2400 Escherichia coli O157:H7 str. EDL933 represssor protein encoded within prophage CP-933R NP_287827.1 2157531 D 155864 CDS NP_287828.1 15801810 961144 2158194..2158373 1 NC_002655.2 hypothetical protein 2158373 961144 Z2402 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287828.1 2158194 D 155864 CDS NP_287829.1 15801811 961145 complement(2158351..2158527) 1 NC_002655.2 hypothetical protein 2158527 961145 Z2403 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287829.1 2158351 R 155864 CDS NP_287830.1 15801812 961147 complement(2158536..2159147) 1 NC_002655.2 prophage CP-933R superinfection exclusion protein 2159147 sieB 961147 sieB Escherichia coli O157:H7 str. EDL933 prophage CP-933R superinfection exclusion protein NP_287830.1 2158536 R 155864 CDS NP_287831.1 15801813 961149 2159454..2159687 1 NC_002655.2 Rac prophage Kil protein; Kil overexpression leads to morphological defects and inhibits cell division; FtsZ inhibitor protein 2159687 kil 961149 kil Escherichia coli O157:H7 str. EDL933 FtsZ inhibitor protein NP_287831.1 2159454 D 155864 CDS NP_287832.1 15801814 961150 2159932..2160207 1 NC_002655.2 Rac prophage hypothetical protein; hypothetical protein 2160207 racC 961150 racC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287832.1 2159932 D 155864 CDS NP_287833.1 15801815 961151 2160309..2162909 1 NC_002655.2 The RecE (also known as exonuclease VIII) pathway is an alternative pathway for the initiation of homologous recombination in Escherichia coli. The RecE pathway is activated in recB, recC sbcA (suppressors of recB and recC) mutants. Activation of the RecE pathway results in the production of at least two phage proteins relevant for recombinational repair. RecE is a duplex DNA-specific exonuclease which produces 3' overhangs in duplex DNA by preferentially degrading the 5'-ending strands. Recombinational repair of E.coli chromosomal DNA involves as well other proteins: RecA, RecF, RecJ, RecO, RecR, and RuvC.; exonuclease VIII 2162909 recE 961151 recE Escherichia coli O157:H7 str. EDL933 exonuclease VIII NP_287833.1 2160309 D 155864 CDS NP_287834.1 15801816 961152 2162902..2163711 1 NC_002655.2 recombination and repair protein RecT 2163711 recT 961152 recT Escherichia coli O157:H7 str. EDL933 recombination and repair protein RecT NP_287834.1 2162902 D 155864 CDS NP_287835.1 15801817 961165 2163767..2163916 1 NC_002655.2 seems to be involved in restriction alleviation and enhancement of modification by EcoKI, but not in restriction alleviation of type III restriction systems; Rac prophage; restriction alleviation and modification protein 2163916 lar 961165 lar Escherichia coli O157:H7 str. EDL933 restriction alleviation and modification protein NP_287835.1 2163767 D 155864 CDS NP_287836.1 15801818 961168 2163882..2164142 1 NC_002655.2 Rac prophage; hypothetical protein 2164142 ydaC 961168 ydaC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287836.1 2163882 D 155864 CDS NP_287837.1 15801819 961170 2164218..2164457 1 NC_002655.2 hypothetical protein 2164457 ydaQ 961170 ydaQ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287837.1 2164218 D 155864 CDS NP_287838.1 15801820 961182 2164459..2165694 1 NC_002655.2 integrase for prophage CP-933R 2165694 intR 961182 intR Escherichia coli O157:H7 str. EDL933 integrase for prophage CP-933R NP_287838.1 2164459 D 155864 CDS NP_287839.1 15801821 961183 2165746..2166681 1 NC_002655.2 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 2166681 ydaO 961183 ydaO Escherichia coli O157:H7 str. EDL933 C32 tRNA thiolase NP_287839.1 2165746 D 155864 CDS NP_287840.1 15801822 961184 complement(2166810..2168183) 1 NC_002655.2 exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA; ATP-dependent RNA helicase DbpA 2168183 dbpA 961184 dbpA Escherichia coli O157:H7 str. EDL933 ATP-dependent RNA helicase DbpA NP_287840.1 2166810 R 155864 CDS NP_287841.1 15801823 961186 complement(2168661..2169644) 1 NC_002655.2 zinc transporter 2169644 zntB 961186 zntB Escherichia coli O157:H7 str. EDL933 zinc transporter NP_287841.1 2168661 R 155864 CDS NP_287842.1 15801824 961215 2169839..2171131 1 NC_002655.2 hypothetical protein 2171131 961215 Z2421 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287842.1 2169839 D 155864 CDS NP_287843.1 15801825 961224 complement(2171152..2171715) 1 NC_002655.2 hypothetical protein 2171715 ydaL 961224 ydaL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287843.1 2171152 R 155864 CDS NP_287844.1 15801826 961256 complement(2172045..2172953) 1 NC_002655.2 DNA-binding transcriptional regulator 2172953 ydaK 961256 ydaK Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator NP_287844.1 2172045 R 155864 CDS NP_287845.1 15801827 961259 2173129..2174439 1 NC_002655.2 aminohydrolase 2174439 ydaJ 961259 ydaJ Escherichia coli O157:H7 str. EDL933 aminohydrolase NP_287845.1 2173129 D 155864 CDS NP_287846.1 15801828 961261 2174439..2175884 1 NC_002655.2 hypothetical protein 2175884 961261 Z2427 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287846.1 2174439 D 155864 CDS NP_287847.1 15801829 961262 2175921..2176718 1 NC_002655.2 pump protein; disrupted by IS629 2176718 961262 Z2428 Escherichia coli O157:H7 str. EDL933 pump protein; disrupted by IS629 NP_287847.1 2175921 D 155864 CDS NP_287848.1 15801830 961266 2176744..2177070 1 NC_002655.2 hypothetical protein 2177070 961266 Z2429 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287848.1 2176744 D 155864 CDS NP_287849.1 15801831 961268 2177310..2177957 1 NC_002655.2 transposase for IS629 2177957 961268 Z2430 Escherichia coli O157:H7 str. EDL933 transposase for IS629 NP_287849.1 2177310 D 155864 CDS NP_287850.1 15801832 961269 2178068..2178760 1 NC_002655.2 pump protein; disrupted by IS629 2178760 961269 Z2431 Escherichia coli O157:H7 str. EDL933 pump protein; disrupted by IS629 NP_287850.1 2178068 D 155864 CDS NP_287851.1 15801833 961272 2178771..2179286 1 NC_002655.2 O-6-alkylguanine-DNA:cysteine-protein methyltransferase 2179286 ogt 961272 ogt Escherichia coli O157:H7 str. EDL933 O-6-alkylguanine-DNA:cysteine-protein methyltransferase NP_287851.1 2178771 D 155864 CDS NP_287852.1 15801834 961273 2179481..2180233 1 NC_002655.2 Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator 2180233 fnr 961273 fnr Escherichia coli O157:H7 str. EDL933 fumarate/nitrate reduction transcriptional regulator NP_287852.1 2179481 D 155864 CDS NP_287853.1 15801835 961275 2180385..2181335 1 NC_002655.2 with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE 2181335 ydaA 961275 ydaA Escherichia coli O157:H7 str. EDL933 universal stress protein UspE NP_287853.1 2180385 D 155864 CDS NP_287854.1 15801836 961276 complement(2181385..2181642) 1 NC_002655.2 hypothetical protein 2181642 ynaJ 961276 ynaJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287854.1 2181385 R 155864 CDS NP_287855.1 15801837 961278 2181886..2182917 1 NC_002655.2 hypothetical protein 2182917 961278 Z2437 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287855.1 2181886 D 155864 CDS NP_287856.1 15801838 961280 complement(2182968..2184602) 1 NC_002655.2 transport periplasmic protein 2184602 961280 Z2438 Escherichia coli O157:H7 str. EDL933 transport periplasmic protein NP_287856.1 2182968 R 155864 CDS NP_287857.1 15801839 961281 complement(2184918..2185817) 1 NC_002655.2 LysR family transcriptional regulator 2185817 ycjZ 961281 ycjZ Escherichia coli O157:H7 str. EDL933 LysR family transcriptional regulator NP_287857.1 2184918 R 155864 CDS NP_287858.1 15801840 961282 2185943..2186875 1 NC_002655.2 hypothetical protein 2186875 961282 Z2442 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287858.1 2185943 D 155864 CDS NP_287859.1 15801841 961283 2186875..2187243 1 NC_002655.2 hypothetical protein 2187243 961283 Z2444 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287859.1 2186875 D 155864 CDS NP_287860.1 15801842 961288 2187182..2187805 1 NC_002655.2 hypothetical protein 2187805 961288 Z2445 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287860.1 2187182 D 155864 CDS NP_287861.1 15801843 961290 2187814..2188464 1 NC_002655.2 hypothetical protein 2188464 961290 Z2446 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287861.1 2187814 D 155864 CDS NP_287862.1 15801844 961294 2188695..2189483 1 NC_002655.2 murein peptide amidase A 2189483 ycjI 961294 ycjI Escherichia coli O157:H7 str. EDL933 murein peptide amidase A NP_287862.1 2188695 D 155864 CDS NP_287863.1 15801845 961300 complement(2189458..2190423) 1 NC_002655.2 muconate cycloisomerase I 2190423 ycjG 961300 ycjG Escherichia coli O157:H7 str. EDL933 muconate cycloisomerase I NP_287863.1 2189458 R 155864 CDS NP_287864.1 15801846 961304 2190542..2191048 1 NC_002655.2 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 2191048 tpx 961304 tpx Escherichia coli O157:H7 str. EDL933 thiol peroxidase NP_287864.1 2190542 D 155864 CDS NP_287865.1 15801847 961305 complement(2191092..2192633) 1 NC_002655.2 regulates genes involved in the biosynthesis and transport of aromatic amino acids; DNA-binding transcriptional regulator TyrR 2192633 tyrR 961305 tyrR Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator TyrR NP_287865.1 2191092 R 155864 CDS NP_287866.1 15801848 961307 complement(2192781..2193842) 1 NC_002655.2 hypothetical protein 2193842 ycjF 961307 ycjF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287866.1 2192781 R 155864 CDS NP_287867.1 15801849 961308 complement(2193839..2195236) 1 NC_002655.2 hypothetical protein 2195236 ycjX 961308 ycjX Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287867.1 2193839 R 155864 CDS NP_287868.1 15801850 961309 2195391..2196389 1 NC_002655.2 LACI-type transcriptional regulator 2196389 ycjW 961309 ycjW Escherichia coli O157:H7 str. EDL933 LACI-type transcriptional regulator NP_287868.1 2195391 D 155864 CDS NP_287869.1 15801851 961310 complement(2196501..2197406) 1 NC_002655.2 hypothetical protein 2197406 ompG 961310 ompG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287869.1 2196501 R 155864 CDS NP_287870.1 15801852 961311 complement(2197451..2198533) 1 NC_002655.2 ABC transporter ATP-binding protein 2198533 ycjV 961311 ycjV Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_287870.1 2197451 R 155864 CDS NP_287871.1 15801853 961312 complement(2198547..2199206) 1 NC_002655.2 beta-phosphoglucomutase 2199206 ycjU 961312 ycjU Escherichia coli O157:H7 str. EDL933 beta-phosphoglucomutase NP_287871.1 2198547 R 155864 CDS NP_287872.1 15801854 961313 complement(2199203..2201470) 1 NC_002655.2 hypothetical protein 2201470 ycjT 961313 ycjT Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287872.1 2199203 R 155864 CDS NP_287873.1 15801855 961314 complement(2201467..2202522) 1 NC_002655.2 dehydrogenase 2202522 ycjS 961314 ycjS Escherichia coli O157:H7 str. EDL933 dehydrogenase NP_287873.1 2201467 R 155864 CDS NP_287874.1 15801856 961317 complement(2202532..2203320) 1 NC_002655.2 transient receptor potential locus 2203320 961317 Z2469 Escherichia coli O157:H7 str. EDL933 transient receptor potential locus NP_287874.1 2202532 R 155864 CDS NP_287875.1 15801857 961318 complement(2203338..2204390) 1 NC_002655.2 oxidoreductase 2204390 ycjQ 961318 ycjQ Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_287875.1 2203338 R 155864 CDS NP_287876.1 15801858 961319 complement(2204421..2205263) 1 NC_002655.2 transport system permease 2205263 ycjP 961319 ycjP Escherichia coli O157:H7 str. EDL933 transport system permease NP_287876.1 2204421 R 155864 CDS NP_287877.1 15801859 961322 complement(2205250..2206131) 1 NC_002655.2 binding-protein dependent transport protein 2206131 ycjO 961322 ycjO Escherichia coli O157:H7 str. EDL933 binding-protein dependent transport protein NP_287877.1 2205250 R 155864 CDS NP_287878.1 15804994 959646 complement(2206152..2207444) 1 NC_002655.2 sugar-binding periplasmic protein 2207444 959646 Z2474m Escherichia coli O157:H7 str. EDL933 sugar-binding periplasmic protein NP_287878.1 2206152 R 155864 CDS NP_287879.1 15804988 959629 complement(join(2207458..2208810,2208810..2209136)) 1 NC_002655.2 glycosidase 2209136 ycjM 959629 ycjM Escherichia coli O157:H7 str. EDL933 glycosidase NP_287879.1 2207458 R 155864 CDS NP_287880.1 15801860 961323 complement(2209347..2209661) 1 NC_002655.2 rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide; thiosulfate:cyanide sulfurtransferase 2209661 pspE 961323 pspE Escherichia coli O157:H7 str. EDL933 thiosulfate:cyanide sulfurtransferase NP_287880.1 2209347 R 155864 CDS NP_287881.1 15801861 961326 complement(2209736..2209957) 1 NC_002655.2 peripheral inner membrane phage-shock protein 2209957 pspD 961326 pspD Escherichia coli O157:H7 str. EDL933 peripheral inner membrane phage-shock protein NP_287881.1 2209736 R 155864 CDS NP_287882.1 15801862 961328 complement(2209966..2210325) 1 NC_002655.2 with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock; DNA-binding transcriptional activator PspC 2210325 pspC 961328 pspC Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional activator PspC NP_287882.1 2209966 R 155864 CDS NP_287883.1 15801863 961330 complement(2210325..2210549) 1 NC_002655.2 acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding; phage shock protein B 2210549 pspB 961330 pspB Escherichia coli O157:H7 str. EDL933 phage shock protein B NP_287883.1 2210325 R 155864 CDS NP_287884.1 15801864 961336 complement(2210603..2211271) 1 NC_002655.2 involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF; phage shock protein PspA 2211271 pspA 961336 pspA Escherichia coli O157:H7 str. EDL933 phage shock protein PspA NP_287884.1 2210603 R 155864 CDS NP_287885.2 161367607 961337 2211438..2212415 1 NC_002655.2 transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor; phage shock protein operon transcriptional activator 2212415 pspF 961337 pspF Escherichia coli O157:H7 str. EDL933 phage shock protein operon transcriptional activator NP_287885.2 2211438 D 155864 CDS NP_287886.1 15801866 961338 complement(2212546..2213811) 1 NC_002655.2 putrescine-inducible GABA aminotransferase; catalyzes the formation of glutamate and succinate semialdehyde from 4-aminobutyrate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 2213811 goaG 961338 goaG Escherichia coli O157:H7 str. EDL933 4-aminobutyrate aminotransferase NP_287886.1 2212546 R 155864 CDS NP_287887.1 15801867 961340 complement(2213849..2215129) 1 NC_002655.2 oxidoreductase 2215129 ordL 961340 ordL Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_287887.1 2213849 R 155864 CDS NP_287888.1 15801868 961341 complement(2215131..2216618) 1 NC_002655.2 catalyzes the formation of gamma-glutamyl-gamma-aminobutyrate from Gamma-glutamyl-gamma-aminobutyraldehyde; involved in putrescine degradation; gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase 2216618 aldH 961341 aldH Escherichia coli O157:H7 str. EDL933 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase NP_287888.1 2215131 R 155864 CDS NP_287889.1 15801869 961342 complement(2216768..2217325) 1 NC_002655.2 regulates genes involved in putrescine degradation; DNA-binding transcriptional repressor PuuR 2217325 ycjC 961342 ycjC Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional repressor PuuR NP_287889.1 2216768 R 155864 CDS NP_287890.1 15801870 961343 complement(2217352..2218128) 1 NC_002655.2 catalyzes the degradation of gamma-glutamyl-gamma-aminobutyrate into glutamate and gamma-aminobutyrate; gamma-glutamyl-gamma-aminobutyrate hydrolase 2218128 puuD 961343 puuD Escherichia coli O157:H7 str. EDL933 gamma-glutamyl-gamma-aminobutyrate hydrolase NP_287890.1 2217352 R 155864 CDS NP_287891.1 15801871 961344 2218250..2219746 1 NC_002655.2 glutamine synthetase 2219746 961344 Z2491 Escherichia coli O157:H7 str. EDL933 glutamine synthetase NP_287891.1 2218250 D 155864 CDS NP_287892.1 15801872 961345 2220049..2221434 1 NC_002655.2 amino acid/amine transport protein 2221434 ycjJ 961345 ycjJ Escherichia coli O157:H7 str. EDL933 amino acid/amine transport protein NP_287892.1 2220049 D 155864 CDS NP_287893.1 15801873 961347 2221569..2221814 1 NC_002655.2 hypothetical protein 2221814 ymjA 961347 ymjA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287893.1 2221569 D 155864 CDS NP_287894.1 15801874 961348 2222128..2223771 1 NC_002655.2 peptide transport periplasmic protein 2223771 sapA 961348 sapA Escherichia coli O157:H7 str. EDL933 peptide transport periplasmic protein NP_287894.1 2222128 D 155864 CDS NP_287895.1 15801875 961349 2223768..2224733 1 NC_002655.2 peptide transport permease 2224733 sapB 961349 sapB Escherichia coli O157:H7 str. EDL933 peptide transport permease NP_287895.1 2223768 D 155864 CDS NP_287896.1 15801876 961350 2224720..2225610 1 NC_002655.2 peptide transport permease 2225610 sapC 961350 sapC Escherichia coli O157:H7 str. EDL933 peptide transport permease NP_287896.1 2224720 D 155864 CDS NP_287897.1 15801877 961351 2225610..2226602 1 NC_002655.2 peptide ABC transporter ATP-binding protein 2226602 sapD 961351 sapD Escherichia coli O157:H7 str. EDL933 peptide ABC transporter ATP-binding protein NP_287897.1 2225610 D 155864 CDS NP_287898.1 15801878 961352 2226604..2227410 1 NC_002655.2 peptide ABC transporter ATP-binding protein 2227410 sapF 961352 sapF Escherichia coli O157:H7 str. EDL933 peptide ABC transporter ATP-binding protein NP_287898.1 2226604 D 155864 CDS NP_287899.1 15801879 961355 complement(2227462..2227902) 1 NC_002655.2 membrane transport protein 2227902 961355 Z2501 Escherichia coli O157:H7 str. EDL933 membrane transport protein NP_287899.1 2227462 R 155864 CDS NP_287900.1 15801880 961357 complement(2227907..2228626) 1 NC_002655.2 membrane transport protein 2228626 961357 Z2503 Escherichia coli O157:H7 str. EDL933 membrane transport protein NP_287900.1 2227907 R 155864 CDS NP_287901.1 15801881 961358 complement(2228635..2229072) 1 NC_002655.2 outer membrane channel protein 2229072 961358 Z2504 Escherichia coli O157:H7 str. EDL933 outer membrane channel protein NP_287901.1 2228635 R 155864 CDS NP_287902.1 15801882 961359 complement(2228981..2230009) 1 NC_002655.2 outer membrane channel protein 2230009 961359 Z2506 Escherichia coli O157:H7 str. EDL933 outer membrane channel protein NP_287902.1 2228981 R 155864 CDS NP_287903.1 15801883 961360 complement(2230013..2230180) 1 NC_002655.2 hypothetical protein 2230180 961360 Z2507 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287903.1 2230013 R 155864 CDS NP_287904.1 15801884 961362 complement(2230032..2233115) 1 NC_002655.2 efflux pump protein 2233115 961362 Z2508 Escherichia coli O157:H7 str. EDL933 efflux pump protein NP_287904.1 2230032 R 155864 CDS NP_287905.1 15801885 961364 complement(2233115..2234236) 1 NC_002655.2 efflux pump protein 2234236 961364 Z2509 Escherichia coli O157:H7 str. EDL933 efflux pump protein NP_287905.1 2233115 R 155864 CDS NP_287906.1 15801886 961365 complement(2234385..2234951) 1 NC_002655.2 transcriptional repressor 2234951 961365 Z2510 Escherichia coli O157:H7 str. EDL933 transcriptional repressor NP_287906.1 2234385 R 155864 CDS NP_287907.1 15801887 961366 2234706..2235092 1 NC_002655.2 No significant matches; hypothetical protein 2235092 961366 Z2511 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287907.1 2234706 D 155864 CDS NP_287908.1 15801888 961367 2235429..2236217 1 NC_002655.2 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-ACP reductase 2236217 fabI 961367 fabI Escherichia coli O157:H7 str. EDL933 enoyl-ACP reductase NP_287908.1 2235429 D 155864 CDS NP_287909.2 161367606 961369 2236362..2237489 1 NC_002655.2 oxidoreductase 2237489 yciW 961369 yciW Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_287909.2 2236362 D 155864 CDS NP_287910.1 15801890 961370 2237557..2239491 1 NC_002655.2 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II 2239491 rnb 961370 rnb Escherichia coli O157:H7 str. EDL933 exoribonuclease II NP_287910.1 2237557 D 155864 CDS NP_287911.1 15801891 961371 2239726..2241711 1 NC_002655.2 c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP; RNase II stability modulator 2241711 yciR 961371 yciR Escherichia coli O157:H7 str. EDL933 RNase II stability modulator NP_287911.1 2239726 D 155864 CDS NP_287912.1 15801892 961372 2241850..2242032 1 NC_002655.2 No significant matches; hypothetical protein 2242032 961372 Z2519 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287912.1 2241850 D 155864 CDS NP_287913.1 15801893 961374 2242123..2242872 1 NC_002655.2 DEOR-type transcriptional regulator 2242872 961374 Z2521 Escherichia coli O157:H7 str. EDL933 DEOR-type transcriptional regulator NP_287913.1 2242123 D 155864 CDS NP_287914.1 15801894 961375 2243141..2243359 1 NC_002655.2 lipoprotein 2243359 osmB 961375 osmB Escherichia coli O157:H7 str. EDL933 lipoprotein NP_287914.1 2243141 D 155864 CDS NP_287915.1 15801895 961376 complement(2243485..2243814) 1 NC_002655.2 involved in start site selection during the initiation of translation; translation initiation factor Sui1 2243814 yciH 961376 yciH Escherichia coli O157:H7 str. EDL933 translation initiation factor Sui1 NP_287915.1 2243485 R 155864 CDS NP_287916.1 15801896 961377 complement(2243811..2244548) 1 NC_002655.2 OMP decarboxylase; OMPDCase; OMPdecase; type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 2244548 pyrF 961377 pyrF Escherichia coli O157:H7 str. EDL933 orotidine 5'-phosphate decarboxylase NP_287916.1 2243811 R 155864 CDS NP_287917.1 15801897 961378 complement(2244741..2245910) 1 NC_002655.2 tetratricopeptide repeat protein 2245910 yciM 961378 yciM Escherichia coli O157:H7 str. EDL933 tetratricopeptide repeat protein NP_287917.1 2244741 R 155864 CDS NP_287918.1 15801898 961379 complement(2245917..2246225) 1 NC_002655.2 hypothetical protein 2246225 yciS 961379 yciS Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287918.1 2245917 R 155864 CDS NP_287919.1 15801899 961380 complement(2246374..2247138) 1 NC_002655.2 phosphatidylglycerophosphatase B 2247138 pgpB 961380 pgpB Escherichia coli O157:H7 str. EDL933 phosphatidylglycerophosphatase B NP_287919.1 2246374 R 155864 CDS NP_287920.1 15801900 961381 2247309..2247899 1 NC_002655.2 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II 2247899 ribA 961381 ribA Escherichia coli O157:H7 str. EDL933 GTP cyclohydrolase II NP_287920.1 2247309 D 155864 CDS NP_287921.1 15801901 961382 complement(2247963..2250638) 1 NC_002655.2 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 2250638 acnA 961382 acnA Escherichia coli O157:H7 str. EDL933 aconitate hydratase NP_287921.1 2247963 R 155864 CDS NP_287922.1 15801902 961383 complement(2251011..2251190) 1 NC_002655.2 No significant matches; hypothetical protein 2251190 961383 Z2533 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287922.1 2251011 R 155864 CDS NP_287923.1 15801903 961385 complement(2251181..2251321) 1 NC_002655.2 No significant matches; hypothetical protein 2251321 961385 Z2534 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287923.1 2251181 R 155864 CDS NP_287924.1 15801904 961386 complement(2251640..2252614) 1 NC_002655.2 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB 2252614 cysB 961386 cysB Escherichia coli O157:H7 str. EDL933 transcriptional regulator CysB NP_287924.1 2251640 R 155864 CDS NP_287925.1 15801905 961387 complement(2252824..2255421) 1 NC_002655.2 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 2255421 topA 961387 topA Escherichia coli O157:H7 str. EDL933 DNA topoisomerase I NP_287925.1 2252824 R 155864 CDS NP_287926.1 15801906 961388 2255801..2256052 1 NC_002655.2 hypothetical protein 2256052 yciN 961388 yciN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287926.1 2255801 D 155864 CDS NP_287927.1 15801907 961389 complement(2256088..2257137) 1 NC_002655.2 SohB; periplasmic protein; member of the peptidase S49 family; periplasmic protease 2257137 sohB 961389 sohB Escherichia coli O157:H7 str. EDL933 periplasmic protease NP_287927.1 2256088 R 155864 CDS NP_287928.1 15801908 961390 2257357..2258115 1 NC_002655.2 short chain dehydrogenase 2258115 yciK 961390 yciK Escherichia coli O157:H7 str. EDL933 short chain dehydrogenase NP_287928.1 2257357 D 155864 CDS NP_287929.1 15801909 961391 2258112..2258702 1 NC_002655.2 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase 2258702 btuR 961391 btuR Escherichia coli O157:H7 str. EDL933 cob(I)yrinic acid a,c-diamide adenosyltransferase NP_287929.1 2258112 D 155864 CDS NP_287930.1 15801910 961392 complement(2258742..2259614) 1 NC_002655.2 catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; 23S rRNA pseudouridylate synthase B 2259614 yciL 961392 yciL Escherichia coli O157:H7 str. EDL933 23S rRNA pseudouridylate synthase B NP_287930.1 2258742 R 155864 CDS NP_287931.1 15801911 961393 complement(2259827..2261410) 1 NC_002655.2 hypothetical protein 2261410 961393 Z2542 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287931.1 2259827 R 155864 CDS NP_287932.1 15801912 961394 complement(2261438..2262094) 1 NC_002655.2 hypothetical protein 2262094 yciO 961394 yciO Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287932.1 2261438 R 155864 CDS NP_287933.1 15801913 961395 complement(2262055..2262936) 1 NC_002655.2 hypothetical protein 2262936 yciV 961395 yciV Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287933.1 2262055 R 155864 CDS NP_287935.1 15804985 959632 join(2263210..2264475,2264477..2264773) 1 NC_002655.2 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 2264773 trpE 959632 trpE Escherichia coli O157:H7 str. EDL933 anthranilate synthase component I NP_287935.1 2263210 D 155864 CDS NP_287936.1 15801915 961397 2264773..2266368 1 NC_002655.2 bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis; bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase 2266368 trpD 961397 trpD Escherichia coli O157:H7 str. EDL933 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase NP_287936.1 2264773 D 155864 CDS NP_287937.1 15801916 961398 2266369..2267730 1 NC_002655.2 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 2267730 trpC 961398 trpC Escherichia coli O157:H7 str. EDL933 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase NP_287937.1 2266369 D 155864 CDS NP_287938.1 15801917 961399 2267742..2268935 1 NC_002655.2 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 2268935 trpB 961399 trpB Escherichia coli O157:H7 str. EDL933 tryptophan synthase subunit beta NP_287938.1 2267742 D 155864 CDS NP_287939.1 15801918 961400 2268935..2269741 1 NC_002655.2 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 2269741 trpA 961400 trpA Escherichia coli O157:H7 str. EDL933 tryptophan synthase subunit alpha NP_287939.1 2268935 D 155864 CDS NP_287940.1 15801919 961402 2270098..2270301 1 NC_002655.2 hypothetical protein 2270301 yciG 961402 yciG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287940.1 2270098 D 155864 CDS NP_287941.1 15801920 961403 2270387..2270887 1 NC_002655.2 hypothetical protein 2270887 yciF 961403 yciF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287941.1 2270387 D 155864 CDS NP_287942.1 15801921 961404 2270933..2271439 1 NC_002655.2 hypothetical protein 2271439 yciE 961404 yciE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287942.1 2270933 D 155864 CDS NP_287943.1 15801922 961405 complement(2271499..2271606) 1 NC_002655.2 hypothetical protein 2271606 961405 Z2557 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287943.1 2271499 R 155864 CDS NP_287944.1 15801923 961406 complement(2272056..2272193) 1 NC_002655.2 No significant matches; hypothetical protein 2272193 961406 Z2558 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287944.1 2272056 R 155864 CDS NP_287945.1 15801924 961408 complement(2272753..2273262) 1 NC_002655.2 hypothetical protein 2273262 961408 Z2560 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287945.1 2272753 R 155864 CDS NP_287946.1 15801925 961409 2273635..2273799 1 NC_002655.2 transposase (partial) 2273799 961409 Z2561 Escherichia coli O157:H7 str. EDL933 transposase (partial) NP_287946.1 2273635 D 155864 CDS NP_287947.1 15801926 961410 2274033..2274284 1 NC_002655.2 transposase (partial) 2274284 961410 Z2562 Escherichia coli O157:H7 str. EDL933 transposase (partial) NP_287947.1 2274033 D 155864 CDS NP_287948.1 15801927 961411 2274294..2274476 1 NC_002655.2 transposase (partial) 2274476 961411 Z2563 Escherichia coli O157:H7 str. EDL933 transposase (partial) NP_287948.1 2274294 D 155864 CDS NP_287949.1 15801928 961412 complement(2274910..2275500) 1 NC_002655.2 chaperone protein 2275500 961412 Z2565 Escherichia coli O157:H7 str. EDL933 chaperone protein NP_287949.1 2274910 R 155864 CDS NP_287950.1 15801929 961413 2275684..2276331 1 NC_002655.2 hypothetical protein 2276331 961413 Z6010 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287950.1 2275684 D 155864 CDS NP_287951.1 15801930 961414 complement(2276468..2276653) 1 NC_002655.2 No Hits; hypothetical protein 2276653 961414 Z6011 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287951.1 2276468 R 155864 CDS NP_287952.1 15801931 961415 complement(2277086..2277355) 1 NC_002655.2 hypothetical protein 2277355 961415 Z6012 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287952.1 2277086 R 155864 CDS NP_287953.1 15801932 961416 2277639..2278040 1 NC_002655.2 hypothetical protein 2278040 961416 Z6014 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287953.1 2277639 D 155864 CDS NP_287954.1 15801933 961417 2278037..2278384 1 NC_002655.2 hypothetical protein 2278384 961417 Z6015 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287954.1 2278037 D 155864 CDS NP_287955.1 15801934 961420 2278434..2279972 1 NC_002655.2 hypothetical protein 2279972 961420 Z6016 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287955.1 2278434 D 155864 CDS NP_287956.1 15801935 961421 2280257..2280604 1 NC_002655.2 transposase 2280604 961421 Z6017 Escherichia coli O157:H7 str. EDL933 transposase NP_287956.1 2280257 D 155864 CDS NP_287957.1 15801936 961427 2280634..2280891 1 NC_002655.2 transposase 2280891 961427 Z6019 Escherichia coli O157:H7 str. EDL933 transposase NP_287957.1 2280634 D 155864 CDS NP_287958.1 15801937 961428 complement(2280938..2281507) 1 NC_002655.2 hypothetical protein 2281507 961428 Z6020 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287958.1 2280938 R 155864 CDS NP_287959.1 15801938 961429 complement(2281573..2282484) 1 NC_002655.2 hypothetical protein 2282484 961429 Z6021 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287959.1 2281573 R 155864 CDS NP_287960.1 15801939 961430 2282949..2283650 1 NC_002655.2 integrase fragment 2283650 961430 Z6022 Escherichia coli O157:H7 str. EDL933 integrase fragment NP_287960.1 2282949 D 155864 CDS NP_287961.1 15801940 961432 2284311..2285636 1 NC_002655.2 hypothetical protein 2285636 961432 Z6024 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287961.1 2284311 D 155864 CDS NP_287962.1 15801941 961434 complement(2285976..2286506) 1 NC_002655.2 hypothetical protein 2286506 961434 Z6025 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287962.1 2285976 R 155864 CDS NP_287963.1 15801942 961435 complement(2286663..2286932) 1 NC_002655.2 hypothetical protein 2286932 961435 Z6026 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287963.1 2286663 R 155864 CDS NP_287964.1 15801943 961436 complement(2286934..2288247) 1 NC_002655.2 tail fiber protein of cryptic prophage CP-933P 2288247 961436 Z6027 Escherichia coli O157:H7 str. EDL933 tail fiber protein of cryptic prophage CP-933P NP_287964.1 2286934 R 155864 CDS NP_287965.1 15801944 961437 complement(2288399..2288998) 1 NC_002655.2 Lom-like outer membrane protein of cryptic prophage CP-933P 2288998 lomP 961437 lomP Escherichia coli O157:H7 str. EDL933 Lom-like outer membrane protein of cryptic prophage CP-933P NP_287965.1 2288399 R 155864 CDS NP_287966.1 15801945 961438 complement(2289066..2291414) 1 NC_002655.2 tail component of cryptic prophage CP-933P 2291414 961438 Z6029 Escherichia coli O157:H7 str. EDL933 tail component of cryptic prophage CP-933P NP_287966.1 2289066 R 155864 CDS NP_287967.1 15801946 961439 complement(2291363..2292718) 1 NC_002655.2 tail component of cryptic prophage CP-933P 2292718 961439 Z6030 Escherichia coli O157:H7 str. EDL933 tail component of cryptic prophage CP-933P NP_287967.1 2291363 R 155864 CDS NP_287968.1 15801947 961440 complement(2292880..2293560) 1 NC_002655.2 tail assembly protein of cryptic prophage CP-933P 2293560 961440 Z6031 Escherichia coli O157:H7 str. EDL933 tail assembly protein of cryptic prophage CP-933P NP_287968.1 2292880 R 155864 CDS NP_287969.1 15801948 961441 complement(2293458..2294132) 1 NC_002655.2 tail assembly protein of cryptic prophage CP-933P 2294132 961441 Z6032 Escherichia coli O157:H7 str. EDL933 tail assembly protein of cryptic prophage CP-933P NP_287969.1 2293458 R 155864 CDS NP_287970.1 15801949 961443 complement(2294212..2294910) 1 NC_002655.2 tail component of cryptic prophage CP-933P 2294910 961443 Z6033 Escherichia coli O157:H7 str. EDL933 tail component of cryptic prophage CP-933P NP_287970.1 2294212 R 155864 CDS NP_287971.1 15801950 961445 complement(2295244..2298486) 1 NC_002655.2 tail component of cryptic prophage CP-933P 2298486 961445 Z6034 Escherichia coli O157:H7 str. EDL933 tail component of cryptic prophage CP-933P NP_287971.1 2295244 R 155864 CDS NP_287972.1 15801951 961448 complement(2298534..2298815) 1 NC_002655.2 tail assembly protein of cryptic prophage CP-933P 2298815 961448 Z6035 Escherichia coli O157:H7 str. EDL933 tail assembly protein of cryptic prophage CP-933P NP_287972.1 2298534 R 155864 CDS NP_287973.1 15801952 961451 complement(2298839..2299261) 1 NC_002655.2 tail assembly protein of cryptic prophage CP-933P 2299261 961451 Z6036 Escherichia coli O157:H7 str. EDL933 tail assembly protein of cryptic prophage CP-933P NP_287973.1 2298839 R 155864 CDS NP_287974.1 15801953 961452 complement(2299228..2300013) 1 NC_002655.2 tail component of cryptic prophage CP-933P 2300013 961452 Z6037 Escherichia coli O157:H7 str. EDL933 tail component of cryptic prophage CP-933P NP_287974.1 2299228 R 155864 CDS NP_287975.1 15801954 961455 complement(2300010..2300354) 1 NC_002655.2 structural component of cryptic prophage CP-933P 2300354 961455 Z6038 Escherichia coli O157:H7 str. EDL933 structural component of cryptic prophage CP-933P NP_287975.1 2300010 R 155864 CDS NP_287976.1 15801955 961456 complement(2300351..2300797) 1 NC_002655.2 structural component of cryptic prophage CP-933P 2300797 961456 Z6039 Escherichia coli O157:H7 str. EDL933 structural component of cryptic prophage CP-933P NP_287976.1 2300351 R 155864 CDS NP_287977.1 15801956 961458 complement(2300794..2301051) 1 NC_002655.2 head-tail adaptor of cryptic prophage CP-933P 2301051 961458 Z6040 Escherichia coli O157:H7 str. EDL933 head-tail adaptor of cryptic prophage CP-933P NP_287977.1 2300794 R 155864 CDS NP_287978.1 15801957 961459 complement(2301154..2301480) 1 NC_002655.2 hypothetical protein 2301480 961459 Z6041 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287978.1 2301154 R 155864 CDS NP_287979.1 15801958 961460 complement(2301483..2304062) 1 NC_002655.2 hypothetical protein 2304062 961460 Z6042 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287979.1 2301483 R 155864 CDS NP_287980.1 15801959 961461 complement(2304008..2304229) 1 NC_002655.2 No Hits; hypothetical protein 2304229 961461 Z6043 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287980.1 2304008 R 155864 CDS NP_287981.1 15801960 961462 complement(2304274..2306211) 1 NC_002655.2 hypothetical protein 2306211 961462 Z6044 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287981.1 2304274 R 155864 CDS NP_287982.1 15801961 961463 complement(2306275..2307936) 1 NC_002655.2 terminase subunit encoded by cryptic prophage CP-933P 2307936 961463 Z6045 Escherichia coli O157:H7 str. EDL933 terminase subunit encoded by cryptic prophage CP-933P NP_287982.1 2306275 R 155864 CDS NP_287983.1 15801962 961464 complement(2307933..2308496) 1 NC_002655.2 terminase subunit encoded by cryptic prophage CP-933P 2308496 961464 Z6046 Escherichia coli O157:H7 str. EDL933 terminase subunit encoded by cryptic prophage CP-933P NP_287983.1 2307933 R 155864 CDS NP_287984.1 15801963 961465 complement(2308786..2309151) 1 NC_002655.2 DNAse encoded by cryptic prophage CP-933P 2309151 961465 Z6047 Escherichia coli O157:H7 str. EDL933 DNAse encoded by cryptic prophage CP-933P NP_287984.1 2308786 R 155864 CDS NP_287985.1 15801964 961467 2309193..2309420 1 NC_002655.2 hypothetical protein 2309420 961467 Z6048 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287985.1 2309193 D 155864 CDS NP_287986.1 15801965 961468 complement(2309783..2310250) 1 NC_002655.2 endopeptidase encoded by cryptic prophage CP-933U 2310250 961468 Z6049 Escherichia coli O157:H7 str. EDL933 endopeptidase encoded by cryptic prophage CP-933U NP_287986.1 2309783 R 155864 CDS NP_287987.1 15801966 961470 complement(2310404..2310973) 1 NC_002655.2 antirepressor protein encoded by cryptic prophage CP-933P 2310973 antP 961470 antP Escherichia coli O157:H7 str. EDL933 antirepressor protein encoded by cryptic prophage CP-933P NP_287987.1 2310404 R 155864 CDS NP_287988.1 15801967 961471 complement(2311244..2311777) 1 NC_002655.2 endolysin encoded by cryptic prophage CP-933P 2311777 961471 Z6051 Escherichia coli O157:H7 str. EDL933 endolysin encoded by cryptic prophage CP-933P NP_287988.1 2311244 R 155864 CDS NP_287989.1 15801968 961472 complement(2311828..2312175) 1 NC_002655.2 hypothetical protein 2312175 961472 Z6052 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287989.1 2311828 R 155864 CDS NP_287990.1 15801969 961475 complement(2312177..2312383) 1 NC_002655.2 holin protein encoded by cryptic prophage CP-933P 2312383 961475 Z6053 Escherichia coli O157:H7 str. EDL933 holin protein encoded by cryptic prophage CP-933P NP_287990.1 2312177 R 155864 CDS NP_287991.1 15801970 961476 complement(2312832..2314682) 1 NC_002655.2 hypothetical protein 2314682 961476 Z6054 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287991.1 2312832 R 155864 CDS NP_287992.1 15801971 961477 complement(2314997..2315164) 1 NC_002655.2 hypothetical protein 2315164 961477 Z6055 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287992.1 2314997 R 155864 CDS NP_287993.1 15801972 961478 complement(2315161..2315580) 1 NC_002655.2 hypothetical protein 2315580 961478 Z6056 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287993.1 2315161 R 155864 CDS NP_287994.1 15801973 961483 complement(2316231..2316920) 1 NC_002655.2 Q antiterminator encoded by prophage CP-933P 2316920 961483 Z6060 Escherichia coli O157:H7 str. EDL933 Q antiterminator encoded by prophage CP-933P NP_287994.1 2316231 R 155864 CDS NP_287995.1 15801974 961485 complement(2316917..2317276) 1 NC_002655.2 endonuclease encoded by cryptic prophage CP-933P 2317276 961485 Z6061 Escherichia coli O157:H7 str. EDL933 endonuclease encoded by cryptic prophage CP-933P NP_287995.1 2316917 R 155864 CDS NP_287996.1 15801975 961487 complement(2317289..2318338) 1 NC_002655.2 hypothetical protein 2318338 961487 Z6062 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287996.1 2317289 R 155864 CDS NP_287997.1 15801976 961488 complement(2318786..2318998) 1 NC_002655.2 cell killing protein encoded within cryptic prophage CP-933P 2318998 mokP 961488 mokP Escherichia coli O157:H7 str. EDL933 cell killing protein encoded within cryptic prophage CP-933P NP_287997.1 2318786 R 155864 CDS NP_287998.1 15801977 961489 complement(2319187..2319291) 1 NC_002655.2 No Hits; hypothetical protein 2319291 961489 Z6064 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287998.1 2319187 R 155864 CDS NP_287999.1 15801978 961492 complement(2319407..2320051) 1 NC_002655.2 hypothetical protein 2320051 961492 Z6065 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_287999.1 2319407 R 155864 CDS NP_288000.1 15801979 961495 complement(2320048..2320443) 1 NC_002655.2 exclusion protein ren of cryptic prophage CP-933P 2320443 renP 961495 renP Escherichia coli O157:H7 str. EDL933 exclusion protein ren of cryptic prophage CP-933P NP_288000.1 2320048 R 155864 CDS NP_288001.1 15801980 961498 complement(2320459..2321127) 1 NC_002655.2 hypothetical protein 2321127 961498 Z6067 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288001.1 2320459 R 155864 CDS NP_288002.1 15801981 961499 complement(2321049..2321228) 1 NC_002655.2 hypothetical protein 2321228 961499 Z6068 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288002.1 2321049 R 155864 CDS NP_288003.1 15801982 961500 complement(2321254..2321994) 1 NC_002655.2 acts to load the DnaB helicase onto the intiation site durning DNA replication; replication protein 2321994 961500 Z6069 Escherichia coli O157:H7 str. EDL933 replication protein NP_288003.1 2321254 R 155864 CDS NP_288004.1 15801983 961501 complement(2322001..2322978) 1 NC_002655.2 hypothetical protein 2322978 961501 Z6070 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288004.1 2322001 R 155864 CDS NP_288005.1 15801984 961502 complement(2322986..2323411) 1 NC_002655.2 hypothetical protein 2323411 961502 Z6071 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288005.1 2322986 R 155864 CDS NP_288006.1 15801985 961503 complement(2323408..2323710) 1 NC_002655.2 hypothetical protein 2323710 961503 Z6072 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288006.1 2323408 R 155864 CDS NP_288007.1 15801986 961504 2323745..2324179 1 NC_002655.2 repressor protein encoded by cryptic prophage CP-933P 2324179 961504 Z6073 Escherichia coli O157:H7 str. EDL933 repressor protein encoded by cryptic prophage CP-933P NP_288007.1 2323745 D 155864 CDS NP_288008.1 15801987 961505 2324200..2324391 1 NC_002655.2 hypothetical protein 2324391 961505 Z6074 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288008.1 2324200 D 155864 CDS NP_288009.1 15801988 961507 2324967..2325323 1 NC_002655.2 hypothetical protein 2325323 961507 Z6075 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288009.1 2324967 D 155864 CDS NP_288010.1 15801989 961508 2325395..2325613 1 NC_002655.2 hypothetical protein 2325613 961508 Z6076 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288010.1 2325395 D 155864 CDS NP_288011.1 15801990 961510 2326077..2326370 1 NC_002655.2 inhibitor of cell division encoded by cryptic prophage CP-933P 2326370 961510 Z6078 Escherichia coli O157:H7 str. EDL933 inhibitor of cell division encoded by cryptic prophage CP-933P NP_288011.1 2326077 D 155864 CDS NP_288012.1 15801991 961511 2326358..2326558 1 NC_002655.2 hypothetical protein 2326558 961511 Z6079 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288012.1 2326358 D 155864 CDS NP_288013.1 15801992 961513 2326651..2329122 1 NC_002655.2 exodeoxyribonuclease encoded by cryptic prophage CP-933P 2329122 exoP 961513 exoP Escherichia coli O157:H7 str. EDL933 exodeoxyribonuclease encoded by cryptic prophage CP-933P NP_288013.1 2326651 D 155864 CDS NP_288014.1 15801993 961514 2329195..2329446 1 NC_002655.2 excisionase 2329446 xisP 961514 xisP Escherichia coli O157:H7 str. EDL933 excisionase NP_288014.1 2329195 D 155864 CDS NP_288015.1 15801994 961518 2329466..2329636 1 NC_002655.2 integrase fragment, cryptic prophage CP-933P 2329636 intP_1 961518 intP_1 Escherichia coli O157:H7 str. EDL933 integrase fragment, cryptic prophage CP-933P NP_288015.1 2329466 D 155864 CDS NP_288016.1 15801995 961519 2329684..2330172 1 NC_002655.2 integrase fragment, cryptic prophage CP-933P 2330172 intP_2 961519 intP_2 Escherichia coli O157:H7 str. EDL933 integrase fragment, cryptic prophage CP-933P NP_288016.1 2329684 D 155864 CDS NP_288017.1 15801996 961520 complement(2330435..2330761) 1 NC_002655.2 hypothetical protein 2330761 961520 Z2569 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288017.1 2330435 R 155864 CDS NP_288018.1 15801997 961523 2330896..2331237 1 NC_002655.2 hypothetical protein 2331237 961523 Z2570 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288018.1 2330896 D 155864 CDS NP_288019.1 15801998 961524 2331272..2331832 1 NC_002655.2 spermidine N1-acetyltransferase 2331832 speG 961524 speG Escherichia coli O157:H7 str. EDL933 spermidine N1-acetyltransferase NP_288019.1 2331272 D 155864 CDS NP_288020.2 161367605 961525 complement(2331835..2332545) 1 NC_002655.2 hypothetical protein 2332545 ynfC 961525 ynfC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288020.2 2331835 R 155864 CDS NP_288021.1 15802000 961526 2332650..2332958 1 NC_002655.2 hypothetical protein 2332958 961526 Z2573 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288021.1 2332650 D 155864 CDS NP_288022.1 15802001 961527 2333157..2335583 1 NC_002655.2 oxidoreductase, major subunit 2335583 961527 Z2575 Escherichia coli O157:H7 str. EDL933 oxidoreductase, major subunit NP_288022.1 2333157 D 155864 CDS NP_288023.1 15802002 961528 2335641..2338067 1 NC_002655.2 oxidoreductase, major subunit 2338067 961528 Z2576 Escherichia coli O157:H7 str. EDL933 oxidoreductase, major subunit NP_288023.1 2335641 D 155864 CDS NP_288024.1 15802003 961529 2338078..2338695 1 NC_002655.2 oxidoreductase, Fe-S subunit 2338695 961529 Z2577 Escherichia coli O157:H7 str. EDL933 oxidoreductase, Fe-S subunit NP_288024.1 2338078 D 155864 CDS NP_288025.1 15802004 961530 2338697..2339551 1 NC_002655.2 DMSO reductase anchor subunit 2339551 961530 Z2579 Escherichia coli O157:H7 str. EDL933 DMSO reductase anchor subunit NP_288025.1 2338697 D 155864 CDS NP_288026.2 161367604 961535 2339594..2340208 1 NC_002655.2 binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane; twin-argninine leader-binding protein DmsD 2340208 961535 Z2581 Escherichia coli O157:H7 str. EDL933 twin-argninine leader-binding protein DmsD NP_288026.2 2339594 D 155864 CDS NP_288027.2 161367603 961537 2340402..2341658 1 NC_002655.2 voltage-gated ClC-type chloride channel ClcB 2341658 961537 Z2583 Escherichia coli O157:H7 str. EDL933 voltage-gated ClC-type chloride channel ClcB NP_288027.2 2340402 D 155864 CDS NP_288028.2 161367602 961539 complement(2341611..2342306) 1 NC_002655.2 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 2342306 bioD 961539 bioD Escherichia coli O157:H7 str. EDL933 dithiobiotin synthetase NP_288028.2 2341611 R 155864 CDS NP_288029.1 15802008 961540 complement(2342431..2343651) 1 NC_002655.2 NAGC-like transcriptional regulator 2343651 mlc 961540 mlc Escherichia coli O157:H7 str. EDL933 NAGC-like transcriptional regulator NP_288029.1 2342431 R 155864 CDS NP_288030.1 15802009 961542 complement(2343786..2344679) 1 NC_002655.2 LysR family transcriptional regulator 2344679 ynfL 961542 ynfL Escherichia coli O157:H7 str. EDL933 LysR family transcriptional regulator NP_288030.1 2343786 R 155864 CDS NP_288031.1 15802010 961543 2344786..2346039 1 NC_002655.2 transporter 2346039 ynfM 961543 ynfM Escherichia coli O157:H7 str. EDL933 transporter NP_288031.1 2344786 D 155864 CDS NP_288032.2 161367601 961544 2346463..2346771 1 NC_002655.2 required for growth and survival under moderately acid conditions; acid shock protein 2346771 asr 961544 asr Escherichia coli O157:H7 str. EDL933 acid shock protein NP_288032.2 2346463 D 155864 CDS NP_288033.1 15802012 961545 2347047..2347868 1 NC_002655.2 hypothetical protein 2347868 961545 Z2592 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288033.1 2347047 D 155864 CDS NP_288034.1 15802013 961546 complement(2347907..2348236) 1 NC_002655.2 with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtI 2348236 961546 Z2593 Escherichia coli O157:H7 str. EDL933 multidrug efflux system protein MdtI NP_288034.1 2347907 R 155864 CDS NP_288035.1 15802014 961548 complement(2348223..2348588) 1 NC_002655.2 with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtJ 2348588 961548 Z2594 Escherichia coli O157:H7 str. EDL933 multidrug efflux system protein MdtJ NP_288035.1 2348223 R 155864 CDS NP_288036.1 15802015 961549 2349000..2350034 1 NC_002655.2 transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes; transporter 2350034 tqsA 961549 tqsA Escherichia coli O157:H7 str. EDL933 transporter NP_288036.1 2349000 D 155864 CDS NP_288037.1 15802016 961550 complement(2350059..2351447) 1 NC_002655.2 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase 2351447 pntB 961550 pntB Escherichia coli O157:H7 str. EDL933 pyridine nucleotide transhydrogenase NP_288037.1 2350059 R 155864 CDS NP_288038.1 15802017 961551 complement(2351458..2352990) 1 NC_002655.2 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha 2352990 pntA 961551 pntA Escherichia coli O157:H7 str. EDL933 NAD(P) transhydrogenase subunit alpha NP_288038.1 2351458 R 155864 CDS NP_288039.1 15802018 961552 2353514..2354458 1 NC_002655.2 hypothetical protein 2354458 961552 Z2603 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288039.1 2353514 D 155864 CDS NP_288040.1 15802019 961554 2354644..2356026 1 NC_002655.2 arginine/ornithine antiporter 2356026 961554 Z2605 Escherichia coli O157:H7 str. EDL933 arginine/ornithine antiporter NP_288040.1 2354644 D 155864 CDS NP_288041.1 15802020 961555 2356063..2356785 1 NC_002655.2 short chain dehydrogenase 2356785 ydgB 961555 ydgB Escherichia coli O157:H7 str. EDL933 short chain dehydrogenase NP_288041.1 2356063 D 155864 CDS NP_288042.1 15802021 961556 complement(2356782..2357117) 1 NC_002655.2 hypothetical protein 2357117 ydgC 961556 ydgC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288042.1 2356782 R 155864 CDS NP_288043.1 15802022 961557 2357237..2357965 1 NC_002655.2 response regulator in two-component regulatory system with RstB; DNA-binding transcriptional regulator RstA 2357965 rstA 961557 rstA Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator RstA NP_288043.1 2357237 D 155864 CDS NP_288044.1 15802023 961558 2357969..2359270 1 NC_002655.2 sensor protein RstB 2359270 rstB 961558 rstB Escherichia coli O157:H7 str. EDL933 sensor protein RstB NP_288044.1 2357969 D 155864 CDS NP_288045.1 15802024 961559 2359347..2360276 1 NC_002655.2 binds to DNA replication terminator sequences to prevent passage of replication forks; DNA replication terminus site-binding protein 2360276 tus 961559 tus Escherichia coli O157:H7 str. EDL933 DNA replication terminus site-binding protein NP_288045.1 2359347 D 155864 CDS NP_288046.1 15802025 961561 complement(2360273..2361676) 1 NC_002655.2 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 2361676 fumC 961561 fumC Escherichia coli O157:H7 str. EDL933 fumarate hydratase NP_288046.1 2360273 R 155864 CDS NP_288047.1 15802026 961562 complement(2361819..2363465) 1 NC_002655.2 fumarase A 2363465 fumA 961562 fumA Escherichia coli O157:H7 str. EDL933 fumarase A NP_288047.1 2361819 R 155864 CDS NP_288048.1 15802027 961563 2363664..2364839 1 NC_002655.2 mannose-6-phosphate isomerase 2364839 manA 961563 manA Escherichia coli O157:H7 str. EDL933 mannose-6-phosphate isomerase NP_288048.1 2363664 D 155864 CDS NP_288049.1 15802028 961564 2364940..2366448 1 NC_002655.2 hypothetical protein 2366448 ydgA 961564 ydgA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288049.1 2364940 D 155864 CDS NP_288050.1 15802029 961565 complement(2366493..2366714) 1 NC_002655.2 hypothetical protein 2366714 961565 Z2618 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288050.1 2366493 R 155864 CDS NP_288051.1 15802030 961566 complement(2366729..2367757) 1 NC_002655.2 hypothetical protein 2367757 961566 Z2619 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288051.1 2366729 R 155864 CDS NP_288052.1 15802031 961567 complement(2367796..2369169) 1 NC_002655.2 glucuronide transporter 2369169 uidB 961567 uidB Escherichia coli O157:H7 str. EDL933 glucuronide transporter NP_288052.1 2367796 R 155864 CDS NP_288053.1 15804986 959631 complement(join(2369166..2370296,2370296..2370979)) 1 NC_002655.2 beta-D-glucuronidase 2370979 uidA 959631 uidA Escherichia coli O157:H7 str. EDL933 beta-D-glucuronidase NP_288053.1 2369166 R 155864 CDS NP_288054.1 15802032 961568 complement(2371370..2371960) 1 NC_002655.2 repressor for uid operon 2371960 uidR 961568 uidR Escherichia coli O157:H7 str. EDL933 repressor for uid operon NP_288054.1 2371370 R 155864 CDS NP_288055.1 15802033 961569 complement(2372189..2372956) 1 NC_002655.2 Acts on the hydroxyl group at position 7 of the steroid frame; 7-alpha-hydroxysteroid dehydrogenase 2372956 hdhA 961569 hdhA Escherichia coli O157:H7 str. EDL933 7-alpha-hydroxysteroid dehydrogenase NP_288055.1 2372189 R 155864 CDS NP_288056.1 15802034 961570 complement(2373068..2374096) 1 NC_002655.2 regulates malXY which are involved in maltose-glucose transport; DNA-binding transcriptional repressor MalI 2374096 malI 961570 malI Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional repressor MalI NP_288056.1 2373068 R 155864 CDS NP_288057.1 15802035 961571 2374271..2375863 1 NC_002655.2 phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site; bifunctional PTS system maltose and glucose-specific transporter subunits IICB 2375863 malX 961571 malX Escherichia coli O157:H7 str. EDL933 bifunctional PTS system maltose and glucose-specific transporter subunits IICB NP_288057.1 2374271 D 155864 CDS NP_288058.1 15802036 961572 2375873..2377045 1 NC_002655.2 hypothetical protein 2377045 malY 961572 malY Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288058.1 2375873 D 155864 CDS NP_288059.1 15802037 961573 2377149..2378150 1 NC_002655.2 catalyzes the formation of inosine from adenosine; adenosine deaminase 2378150 add 961573 add Escherichia coli O157:H7 str. EDL933 adenosine deaminase NP_288059.1 2377149 D 155864 CDS NP_288060.2 161367600 961574 complement(2378186..2379226) 1 NC_002655.2 oxidoreductase 2379226 961574 Z2629 Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_288060.2 2378186 R 155864 CDS NP_288061.1 15802039 961575 2379868..2380083 1 NC_002655.2 YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes; oriC-binding nucleoid-associated protein 2380083 961575 Z2631 Escherichia coli O157:H7 str. EDL933 oriC-binding nucleoid-associated protein NP_288061.1 2379868 D 155864 CDS NP_288062.1 15802040 961576 2380145..2380609 1 NC_002655.2 hypothetical protein 2380609 961576 Z2632 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288062.1 2380145 D 155864 CDS NP_288063.1 15802041 961577 2380686..2381267 1 NC_002655.2 Na(+)-translocating NADH-quinone reductase subunit E 2381267 961577 Z2633 Escherichia coli O157:H7 str. EDL933 Na(+)-translocating NADH-quinone reductase subunit E NP_288063.1 2380686 D 155864 CDS NP_288064.1 15802042 961578 2381267..2381845 1 NC_002655.2 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB 2381845 961578 Z2634 Escherichia coli O157:H7 str. EDL933 electron transport complex protein RnfB NP_288064.1 2381267 D 155864 CDS NP_288065.1 15802043 961579 2381838..2384060 1 NC_002655.2 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC 2384060 961579 Z2636 Escherichia coli O157:H7 str. EDL933 electron transport complex protein RnfC NP_288065.1 2381838 D 155864 CDS NP_288066.1 15802044 961580 2384061..2385119 1 NC_002655.2 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD 2385119 rnfD 961580 rnfD Escherichia coli O157:H7 str. EDL933 electron transport complex protein RnfD NP_288066.1 2384061 D 155864 CDS NP_288067.1 15802045 961583 2385123..2385743 1 NC_002655.2 part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG 2385743 961583 Z2640 Escherichia coli O157:H7 str. EDL933 electron transport complex protein RnfG NP_288067.1 2385123 D 155864 CDS NP_288068.1 15802046 961584 2385747..2386442 1 NC_002655.2 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex protein RsxE 2386442 ydgQ 961584 ydgQ Escherichia coli O157:H7 str. EDL933 electron transport complex protein RsxE NP_288068.1 2385747 D 155864 CDS NP_288069.1 15802047 961585 2386442..2387077 1 NC_002655.2 DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines; endonuclease III 2387077 nth 961585 nth Escherichia coli O157:H7 str. EDL933 endonuclease III NP_288069.1 2386442 D 155864 CDS NP_288070.1 15802048 961587 2387688..2389190 1 NC_002655.2 mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation; tripeptide transporter permease 2389190 tppB 961587 tppB Escherichia coli O157:H7 str. EDL933 tripeptide transporter permease NP_288070.1 2387688 D 155864 CDS NP_288071.1 15802049 961588 2389296..2389901 1 NC_002655.2 glutathionine S-transferase 2389901 gst 961588 gst Escherichia coli O157:H7 str. EDL933 glutathionine S-transferase NP_288071.1 2389296 D 155864 CDS NP_288072.1 15802050 961591 complement(2389945..2390808) 1 NC_002655.2 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase 2390808 pdxY 961591 pdxY Escherichia coli O157:H7 str. EDL933 pyridoxamine kinase NP_288072.1 2389945 R 155864 CDS NP_288073.1 15802051 961592 complement(2390867..2392153) 1 NC_002655.2 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 2392153 tyrS 961592 tyrS Escherichia coli O157:H7 str. EDL933 tyrosyl-tRNA synthetase NP_288073.1 2390867 R 155864 CDS NP_288074.1 15802052 961593 complement(2392271..2392927) 1 NC_002655.2 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 2392927 pdxH 961593 pdxH Escherichia coli O157:H7 str. EDL933 pyridoxamine 5'-phosphate oxidase NP_288074.1 2392271 R 155864 CDS NP_288075.1 15802053 961594 complement(2392986..2393234) 1 NC_002655.2 hypothetical protein 2393234 ydhA 961594 ydhA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288075.1 2392986 R 155864 CDS NP_288076.1 15802054 961598 complement(2393413..2394522) 1 NC_002655.2 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase 2394522 anmK 961598 anmK Escherichia coli O157:H7 str. EDL933 anhydro-N-acetylmuramic acid kinase NP_288076.1 2393413 R 155864 CDS NP_288077.1 15802055 961599 2394796..2395263 1 NC_002655.2 hypothetical protein 2395263 slyB 961599 slyB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288077.1 2394796 D 155864 CDS NP_288078.2 161367599 961601 complement(2395310..2395744) 1 NC_002655.2 Transcription regulator that can both activate or repress expression; transcriptional regulator SlyA 2395744 slyA 961601 slyA Escherichia coli O157:H7 str. EDL933 transcriptional regulator SlyA NP_288078.2 2395310 R 155864 CDS NP_288079.1 15802057 961602 2395945..2396181 1 NC_002655.2 hypothetical protein 2396181 961602 Z2658 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288079.1 2395945 D 155864 CDS NP_288080.1 15802058 961603 2396142..2397041 1 NC_002655.2 hypothetical protein 2397041 961603 Z2659 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288080.1 2396142 D 155864 CDS NP_288081.1 15802059 961604 2397041..2399053 1 NC_002655.2 hypothetical protein 2399053 961604 Z2660 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288081.1 2397041 D 155864 CDS NP_288082.1 15802060 961605 complement(2399054..2399575) 1 NC_002655.2 SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water; superoxide dismutase 2399575 sodC 961605 sodC Escherichia coli O157:H7 str. EDL933 superoxide dismutase NP_288082.1 2399054 R 155864 CDS NP_288083.1 15802061 961607 complement(2399764..2400552) 1 NC_002655.2 hypothetical protein 2400552 961607 Z2664 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288083.1 2399764 R 155864 CDS NP_288084.1 15802062 961609 complement(2400601..2400978) 1 NC_002655.2 hypothetical protein 2400978 961609 Z2665 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288084.1 2400601 R 155864 CDS NP_288085.1 15802063 961610 2400943..2401542 1 NC_002655.2 hypothetical protein 2401542 961610 Z2666 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288085.1 2400943 D 155864 CDS NP_288086.1 15802064 961612 2401579..2402676 1 NC_002655.2 FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide; N-ethylmaleimide reductase 2402676 nemA 961612 nemA Escherichia coli O157:H7 str. EDL933 N-ethylmaleimide reductase NP_288086.1 2401579 D 155864 CDS NP_288087.1 15802065 961613 2402757..2403164 1 NC_002655.2 Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione; glyoxalase I 2403164 gloA 961613 gloA Escherichia coli O157:H7 str. EDL933 glyoxalase I NP_288087.1 2402757 D 155864 CDS NP_288088.1 15802066 961614 2403267..2403914 1 NC_002655.2 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T 2403914 rnt 961614 rnt Escherichia coli O157:H7 str. EDL933 ribonuclease T NP_288088.1 2403267 D 155864 CDS NP_288089.1 15802067 961615 2404007..2408623 1 NC_002655.2 similar to the DNA and RNA helicase superfamily II and eukaryotic DEAD family of helicases; longest known protein in E. coli; ATP-dependent helicase Lhr 2408623 lhr 961615 lhr Escherichia coli O157:H7 str. EDL933 ATP-dependent helicase Lhr NP_288089.1 2404007 D 155864 CDS NP_288090.1 15802068 961616 complement(2408674..2409021) 1 NC_002655.2 hypothetical protein 2409021 ydhD 961616 ydhD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288090.1 2408674 R 155864 CDS NP_288091.1 15802069 961617 2409356..2410171 1 NC_002655.2 lipoprotein 2410171 ydhO 961617 ydhO Escherichia coli O157:H7 str. EDL933 lipoprotein NP_288091.1 2409356 D 155864 CDS NP_288092.1 15802070 961618 2410299..2410880 1 NC_002655.2 SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals; superoxide dismutase 2410880 sodB 961618 sodB Escherichia coli O157:H7 str. EDL933 superoxide dismutase NP_288092.1 2410299 D 155864 CDS NP_288093.1 15802071 961620 complement(2411026..2412195) 1 NC_002655.2 transporter 2412195 961620 Z2679 Escherichia coli O157:H7 str. EDL933 transporter NP_288093.1 2411026 R 155864 CDS NP_288094.1 15802072 961621 2412749..2413774 1 NC_002655.2 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR 2413774 purR 961621 purR Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional repressor PurR NP_288094.1 2412749 D 155864 CDS NP_288095.1 15802073 961628 complement(2413771..2414703) 1 NC_002655.2 DNA-binding transcriptional regulator 2414703 ydhB 961628 ydhB Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator NP_288095.1 2413771 R 155864 CDS NP_288096.1 15802074 961629 2414816..2416027 1 NC_002655.2 uncharacterized member of the major facilitator superfamily (MFS); inner membrane transport protein YdhC 2416027 ydhC 961629 ydhC Escherichia coli O157:H7 str. EDL933 inner membrane transport protein YdhC NP_288096.1 2414816 D 155864 CDS NP_288097.1 15802075 961630 2416318..2417466 1 NC_002655.2 catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge; cyclopropane-fatty-acyl-phospholipid synthase 2417466 cfa 961630 cfa Escherichia coli O157:H7 str. EDL933 cyclopropane-fatty-acyl-phospholipid synthase NP_288097.1 2416318 D 155864 CDS NP_288098.1 15802076 961631 complement(2417506..2418147) 1 NC_002655.2 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 2418147 ribE 961631 ribE Escherichia coli O157:H7 str. EDL933 riboflavin synthase subunit alpha NP_288098.1 2417506 R 155864 CDS NP_288099.1 15802077 961632 2418364..2419737 1 NC_002655.2 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein 2419737 ydhE 961632 ydhE Escherichia coli O157:H7 str. EDL933 multidrug efflux protein NP_288099.1 2418364 D 155864 CDS NP_288100.1 15802078 961633 complement(2419778..2421034) 1 NC_002655.2 hypothetical protein 2421034 961633 Z2691 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288100.1 2419778 R 155864 CDS NP_288101.1 15802079 961637 2421607..2421912 1 NC_002655.2 hypothetical protein 2421912 961637 Z2694 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288101.1 2421607 D 155864 CDS NP_288102.1 15802080 961638 2422038..2423642 1 NC_002655.2 hypothetical protein 2423642 961638 Z2695 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288102.1 2422038 D 155864 CDS NP_288103.1 15802081 961640 complement(2423654..2424466) 1 NC_002655.2 hypothetical protein 2424466 961640 Z2696 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288103.1 2423654 R 155864 CDS NP_288104.1 15802082 961641 complement(2424470..2425255) 1 NC_002655.2 hypothetical protein 2425255 ydhU 961641 ydhU Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288104.1 2424470 R 155864 CDS NP_288105.1 15802083 961642 complement(2425252..2425971) 1 NC_002655.2 oxidoreductase, Fe-S subunit 2425971 961642 Z2698 Escherichia coli O157:H7 str. EDL933 oxidoreductase, Fe-S subunit NP_288105.1 2425252 R 155864 CDS NP_288106.1 15802084 961643 complement(2425984..2426631) 1 NC_002655.2 hypothetical protein 2426631 961643 Z2700 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288106.1 2425984 R 155864 CDS NP_288107.1 15802085 961644 complement(2426635..2428737) 1 NC_002655.2 oxidoreductase 2428737 961644 Z2701 Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_288107.1 2426635 R 155864 CDS NP_288108.1 15802086 961645 complement(2428758..2429384) 1 NC_002655.2 hypothetical protein 2429384 961645 Z2702 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288108.1 2428758 R 155864 CDS NP_288109.1 15802087 961646 complement(2429840..2430049) 1 NC_002655.2 hypothetical protein 2430049 961646 Z2703 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288109.1 2429840 R 155864 CDS NP_288110.1 15802088 961647 2430606..2432018 1 NC_002655.2 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 2432018 pykF 961647 pykF Escherichia coli O157:H7 str. EDL933 pyruvate kinase NP_288110.1 2430606 D 155864 CDS NP_288111.1 15802089 961648 2432329..2432565 1 NC_002655.2 murein lipoprotein 2432565 lpp 961648 lpp Escherichia coli O157:H7 str. EDL933 murein lipoprotein NP_288111.1 2432329 D 155864 CDS NP_288112.1 15802090 961649 complement(2432628..2433632) 1 NC_002655.2 hypothetical protein 2433632 ynhG 961649 ynhG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288112.1 2432628 R 155864 CDS NP_288113.1 15802091 961650 complement(2433781..2434197) 1 NC_002655.2 Acts with SufS to catalyze the formation of L-alanine from L-cysteine; cysteine desufuration protein SufE 2434197 ynhA 961650 ynhA Escherichia coli O157:H7 str. EDL933 cysteine desufuration protein SufE NP_288113.1 2433781 R 155864 CDS NP_288114.1 15802092 961651 complement(2434210..2435430) 1 NC_002655.2 catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine; bifunctional cysteine desulfurase/selenocysteine lyase 2435430 961651 Z2708 Escherichia coli O157:H7 str. EDL933 bifunctional cysteine desulfurase/selenocysteine lyase NP_288114.1 2434210 R 155864 CDS NP_288115.1 15802093 961652 complement(2435427..2436698) 1 NC_002655.2 with SufBC activates cysteine desulfurase SufS; cysteine desulfurase 2436698 ynhC 961652 ynhC Escherichia coli O157:H7 str. EDL933 cysteine desulfurase NP_288115.1 2435427 R 155864 CDS NP_288116.1 15802094 961653 complement(2436673..2437419) 1 NC_002655.2 part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE; cysteine desulfurase 2437419 sufC 961653 sufC Escherichia coli O157:H7 str. EDL933 cysteine desulfurase NP_288116.1 2436673 R 155864 CDS NP_288117.1 15802095 961654 complement(2437429..2438955) 1 NC_002655.2 with SufCD activates cysteine desulfurase SufS; cysteine desulfurase 2438955 ynhE 961654 ynhE Escherichia coli O157:H7 str. EDL933 cysteine desulfurase NP_288117.1 2437429 R 155864 CDS NP_288118.1 15802096 961655 complement(2438925..2439293) 1 NC_002655.2 functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein; iron-sulfur cluster assembly scaffold protein 2439293 sufA 961655 sufA Escherichia coli O157:H7 str. EDL933 iron-sulfur cluster assembly scaffold protein NP_288118.1 2438925 R 155864 CDS NP_288119.1 15802097 961656 complement(2439842..2440111) 1 NC_002655.2 hypothetical protein 2440111 961656 Z2713 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288119.1 2439842 R 155864 CDS NP_288120.1 15802098 961657 complement(2440130..2440540) 1 NC_002655.2 hypothetical protein 2440540 961657 Z2714 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288120.1 2440130 R 155864 CDS NP_288121.1 15802099 961658 complement(2440537..2443593) 1 NC_002655.2 oxidase 2443593 ydiJ 961658 ydiJ Escherichia coli O157:H7 str. EDL933 oxidase NP_288121.1 2440537 R 155864 CDS NP_288122.1 15802100 961659 2443982..2445094 1 NC_002655.2 YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function; hypothetical protein 2445094 961659 Z2716 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288122.1 2443982 D 155864 CDS NP_288123.1 15802101 961660 2445496..2445879 1 NC_002655.2 hypothetical protein 2445879 961660 Z2717 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288123.1 2445496 D 155864 CDS NP_288124.1 15802102 961661 2445979..2447193 1 NC_002655.2 transport system permease 2447193 961661 Z2718 Escherichia coli O157:H7 str. EDL933 transport system permease NP_288124.1 2445979 D 155864 CDS NP_288125.1 15802103 961662 2447414..2448685 1 NC_002655.2 amino acid/amine transport protein 2448685 961662 Z2719 Escherichia coli O157:H7 str. EDL933 amino acid/amine transport protein NP_288125.1 2447414 D 155864 CDS NP_288126.1 15802104 961663 2448697..2449563 1 NC_002655.2 YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate; quinate/shikimate dehydrogenase 2449563 aroE 961663 aroE Escherichia coli O157:H7 str. EDL933 quinate/shikimate dehydrogenase NP_288126.1 2448697 D 155864 CDS NP_288127.1 15802105 961664 2449594..2450352 1 NC_002655.2 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 2450352 aroD 961664 aroD Escherichia coli O157:H7 str. EDL933 3-dehydroquinate dehydratase NP_288127.1 2449594 D 155864 CDS NP_288128.1 15802106 961665 2450497..2452092 1 NC_002655.2 hypothetical protein 2452092 ydiF 961665 ydiF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288128.1 2450497 D 155864 CDS NP_288129.2 161367598 961666 2452106..2453257 1 NC_002655.2 may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; acyl-CoA dehydrogenase 2453257 961666 Z2723 Escherichia coli O157:H7 str. EDL933 acyl-CoA dehydrogenase NP_288129.2 2452106 D 155864 CDS NP_288130.1 15802108 961667 complement(2453300..2454211) 1 NC_002655.2 AraC family transcriptional regulator 2454211 961667 Z2724 Escherichia coli O157:H7 str. EDL933 AraC family transcriptional regulator NP_288130.1 2453300 R 155864 CDS NP_288131.1 15802109 961668 2454532..2455296 1 NC_002655.2 YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; electron transfer flavoprotein YdiQ 2455296 ydiQ 961668 ydiQ Escherichia coli O157:H7 str. EDL933 electron transfer flavoprotein YdiQ NP_288131.1 2454532 D 155864 CDS NP_288132.1 15802110 961669 2455316..2456254 1 NC_002655.2 May play a role in a redox process; electron transfer flavoprotein subunit YdiR 2456254 ydiR 961669 ydiR Escherichia coli O157:H7 str. EDL933 electron transfer flavoprotein subunit YdiR NP_288132.1 2455316 D 155864 CDS NP_288133.1 15802111 961670 2456310..2457599 1 NC_002655.2 hypothetical protein 2457599 ydiS 961670 ydiS Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288133.1 2456310 D 155864 CDS NP_288134.1 15802112 961671 2457596..2457889 1 NC_002655.2 hypothetical protein 2457889 ydiT 961671 ydiT Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288134.1 2457596 D 155864 CDS NP_288135.1 15802113 961672 2457892..2459592 1 NC_002655.2 acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids; short chain acyl-CoA synthetase 2459592 ydiD 961672 ydiD Escherichia coli O157:H7 str. EDL933 short chain acyl-CoA synthetase NP_288135.1 2457892 D 155864 CDS NP_288136.1 15802114 961673 complement(2459649..2462027) 1 NC_002655.2 catalyzes the formation of phosphoenolpyruvate from pyruvate; phosphoenolpyruvate synthase 2462027 ppsA 961673 ppsA Escherichia coli O157:H7 str. EDL933 phosphoenolpyruvate synthase NP_288136.1 2459649 R 155864 CDS NP_288137.1 15802115 961674 2462360..2463193 1 NC_002655.2 hypothetical protein 2463193 ydiA 961674 ydiA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288137.1 2462360 D 155864 CDS NP_288138.1 15802116 961675 2463350..2464396 1 NC_002655.2 tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate; phospho-2-dehydro-3-deoxyheptonate aldolase 2464396 aroH 961675 aroH Escherichia coli O157:H7 str. EDL933 phospho-2-dehydro-3-deoxyheptonate aldolase NP_288138.1 2463350 D 155864 CDS NP_288139.1 15802117 961676 2464528..2464719 1 NC_002655.2 hypothetical protein 2464719 ydiE 961676 ydiE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288139.1 2464528 D 155864 CDS NP_288140.1 15802118 961677 complement(2464723..2466159) 1 NC_002655.2 hypothetical protein 2466159 961677 Z2735 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288140.1 2464723 R 155864 CDS NP_288141.1 15802119 961678 complement(2466222..2466935) 1 NC_002655.2 hypothetical protein 2466935 961678 Z2736 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288141.1 2466222 R 155864 CDS NP_288142.1 15802120 961679 complement(2467182..2467646) 1 NC_002655.2 lipoprotein 2467646 nlpC 961679 nlpC Escherichia coli O157:H7 str. EDL933 lipoprotein NP_288142.1 2467182 R 155864 CDS NP_288143.1 15802121 961680 complement(2467724..2468473) 1 NC_002655.2 ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell; vitamin B12-transporter ATPase 2468473 btuD 961680 btuD Escherichia coli O157:H7 str. EDL933 vitamin B12-transporter ATPase NP_288143.1 2467724 R 155864 CDS NP_288144.1 15802122 961681 complement(2468473..2469024) 1 NC_002655.2 similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane; glutathione peroxidase 2469024 btuE 961681 btuE Escherichia coli O157:H7 str. EDL933 glutathione peroxidase NP_288144.1 2468473 R 155864 CDS NP_288145.1 15802123 961682 complement(2469087..2470067) 1 NC_002655.2 with BtuD and BtuF transports vitamin B12 into the cell; vtamin B12-transporter permease 2470067 btuC 961682 btuC Escherichia coli O157:H7 str. EDL933 vtamin B12-transporter permease NP_288145.1 2469087 R 155864 CDS NP_288146.1 15802124 961683 complement(2470169..2470468) 1 NC_002655.2 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha 2470468 ihfA 961683 ihfA Escherichia coli O157:H7 str. EDL933 integration host factor subunit alpha NP_288146.1 2470169 R 155864 CDS NP_288147.1 15802125 961684 complement(2470473..2472860) 1 NC_002655.2 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 2472860 pheT 961684 pheT Escherichia coli O157:H7 str. EDL933 phenylalanyl-tRNA synthetase subunit beta NP_288147.1 2470473 R 155864 CDS NP_288148.1 15802126 961685 complement(2472875..2473858) 1 NC_002655.2 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 2473858 pheS 961685 pheS Escherichia coli O157:H7 str. EDL933 phenylalanyl-tRNA synthetase subunit alpha NP_288148.1 2472875 R 155864 CDS NP_288150.1 15802128 961687 complement(2474308..2474664) 1 NC_002655.2 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 2474664 rplT 961687 rplT Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L20 NP_288150.1 2474308 R 155864 CDS NP_288151.1 15802129 961688 complement(2474717..2474914) 1 NC_002655.2 50S ribosomal protein L35 2474914 rpmI 961688 rpmI Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L35 NP_288151.1 2474717 R 155864 CDS NP_288152.1 15802130 961689 complement(2475011..2475445) 1 NC_002655.2 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 2475445 infC 961689 infC Escherichia coli O157:H7 str. EDL933 translation initiation factor IF-3 NP_288152.1 2475011 R 155864 CDS NP_288153.1 15802131 961690 complement(2475557..2477485) 1 NC_002655.2 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase 2477485 thrS 961690 thrS Escherichia coli O157:H7 str. EDL933 threonyl-tRNA synthetase NP_288153.1 2475557 R 155864 CDS NP_288154.1 15802132 961691 2478008..2479906 1 NC_002655.2 hypothetical protein 2479906 961691 Z2749 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288154.1 2478008 D 155864 CDS NP_288155.1 15802133 961692 complement(2480241..2480999) 1 NC_002655.2 hypothetical protein 2480999 961692 Z2751 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288155.1 2480241 R 155864 CDS NP_288156.1 15802134 961693 2481286..2482215 1 NC_002655.2 6-phosphofructokinase 2482215 pfkB 961693 pfkB Escherichia coli O157:H7 str. EDL933 6-phosphofructokinase NP_288156.1 2481286 D 155864 CDS NP_288157.1 15802135 961694 2482316..2482606 1 NC_002655.2 hypothetical protein 2482606 961694 Z2753 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288157.1 2482316 D 155864 CDS NP_288158.1 15802136 961695 2482712..2483572 1 NC_002655.2 hypothetical protein 2483572 961695 Z2754 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288158.1 2482712 D 155864 CDS NP_288159.1 15802137 961696 complement(2483613..2484149) 1 NC_002655.2 hypothetical protein 2484149 961696 Z2755 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288159.1 2483613 R 155864 CDS NP_288160.1 15802138 961697 2484296..2484964 1 NC_002655.2 YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate; 2-deoxyglucose-6-phosphatase 2484964 961697 Z2756 Escherichia coli O157:H7 str. EDL933 2-deoxyglucose-6-phosphatase NP_288160.1 2484296 D 155864 CDS NP_288161.2 161367597 961698 2485127..2485717 1 NC_002655.2 hypothetical protein 2485717 961698 Z2757 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288161.2 2485127 D 155864 CDS NP_288162.1 15802140 961699 2485850..2487241 1 NC_002655.2 hypothetical protein 2487241 961699 Z2758 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288162.1 2485850 D 155864 CDS NP_288163.1 15802141 961700 complement(2487292..2488047) 1 NC_002655.2 hypothetical protein 2488047 961700 Z2759 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288163.1 2487292 R 155864 CDS NP_288164.1 15802142 961701 complement(2488336..2488599) 1 NC_002655.2 cell division modulator 2488599 961701 Z2760 Escherichia coli O157:H7 str. EDL933 cell division modulator NP_288164.1 2488336 R 155864 CDS NP_288165.1 15802143 961702 2488782..2491043 1 NC_002655.2 Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide; hydroperoxidase II 2491043 katE 961702 katE Escherichia coli O157:H7 str. EDL933 hydroperoxidase II NP_288165.1 2488782 D 155864 CDS NP_288166.1 15802144 961703 complement(2491090..2491848) 1 NC_002655.2 hypothetical protein 2491848 ydjC 961703 ydjC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288166.1 2491090 R 155864 CDS NP_288167.1 15802145 961704 complement(2491861..2493213) 1 NC_002655.2 6-phospho-beta-glucosidase 2493213 celF 961704 celF Escherichia coli O157:H7 str. EDL933 6-phospho-beta-glucosidase NP_288167.1 2491861 R 155864 CDS NP_288168.1 15802146 961705 complement(2493319..2494161) 1 NC_002655.2 represses the celABCDF-ydjC operon involved in carbon uptake; DNA-binding transcriptional regulator ChbR 2494161 celD 961705 celD Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator ChbR NP_288168.1 2493319 R 155864 CDS NP_288169.1 15802147 961706 complement(2494169..2494519) 1 NC_002655.2 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA 2494519 celC 961706 celC Escherichia coli O157:H7 str. EDL933 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA NP_288169.1 2494169 R 155864 CDS NP_288170.1 15802148 961707 complement(2494570..2495928) 1 NC_002655.2 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC 2495928 celB 961707 celB Escherichia coli O157:H7 str. EDL933 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC NP_288170.1 2494570 R 155864 CDS NP_288171.1 15802149 961708 complement(2496013..2496333) 1 NC_002655.2 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB 2496333 celA 961708 celA Escherichia coli O157:H7 str. EDL933 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB NP_288171.1 2496013 R 155864 CDS NP_288172.1 15802150 961709 complement(2496633..2496971) 1 NC_002655.2 osmotically-inducible lipoprotein E; activator of ntr-like gene protein; DNA-binding transcriptional activator OsmE 2496971 osmE 961709 osmE Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional activator OsmE NP_288172.1 2496633 R 155864 CDS NP_288173.1 15802151 961710 2497173..2498000 1 NC_002655.2 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 2498000 nadE 961710 nadE Escherichia coli O157:H7 str. EDL933 NAD synthetase NP_288173.1 2497173 D 155864 CDS NP_288174.1 15802152 961711 2498230..2499117 1 NC_002655.2 3' incision activity; acts with UvrC; nucleotide excision repair endonuclease 2499117 961711 Z2771 Escherichia coli O157:H7 str. EDL933 nucleotide excision repair endonuclease NP_288174.1 2498230 D 155864 CDS NP_288175.1 15802153 961712 complement(2499077..2499715) 1 NC_002655.2 hypothetical protein 2499715 961712 Z2774 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288175.1 2499077 R 155864 CDS NP_288176.1 15802154 961713 complement(2499855..2500340) 1 NC_002655.2 periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP; hypothetical protein 2500340 spy 961713 spy Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288176.1 2499855 R 155864 CDS NP_288177.1 15802155 961715 complement(2500670..2501638) 1 NC_002655.2 catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism; succinylglutamate desuccinylase 2501638 ydjS 961715 ydjS Escherichia coli O157:H7 str. EDL933 succinylglutamate desuccinylase NP_288177.1 2500670 R 155864 CDS NP_288178.1 15802156 961716 complement(2501631..2502974) 1 NC_002655.2 catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation; succinylarginine dihydrolase 2502974 961716 Z2777 Escherichia coli O157:H7 str. EDL933 succinylarginine dihydrolase NP_288178.1 2501631 R 155864 CDS NP_288179.1 15802157 961717 complement(2502971..2504449) 1 NC_002655.2 a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH; succinylglutamic semialdehyde dehydrogenase 2504449 astD 961717 astD Escherichia coli O157:H7 str. EDL933 succinylglutamic semialdehyde dehydrogenase NP_288179.1 2502971 R 155864 CDS NP_288180.1 15802158 961718 complement(2504446..2505480) 1 NC_002655.2 arginine succinyltransferase 2505480 961718 Z2779 Escherichia coli O157:H7 str. EDL933 arginine succinyltransferase NP_288180.1 2504446 R 155864 CDS NP_288181.1 15802159 961719 complement(2505477..2506697) 1 NC_002655.2 catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate; bifunctional succinylornithine transaminase/acetylornithine transaminase 2506697 argD 961719 argD Escherichia coli O157:H7 str. EDL933 bifunctional succinylornithine transaminase/acetylornithine transaminase NP_288181.1 2505477 R 155864 CDS NP_288182.1 15802160 961720 2507143..2507949 1 NC_002655.2 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III 2507949 xthA 961720 xthA Escherichia coli O157:H7 str. EDL933 exonuclease III NP_288182.1 2507143 D 155864 CDS NP_288183.1 15802161 961721 2508068..2508826 1 NC_002655.2 hypothetical protein 2508826 ydjX 961721 ydjX Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288183.1 2508068 D 155864 CDS NP_288184.1 15802162 961722 2508669..2509508 1 NC_002655.2 hypothetical protein 2509508 ydjY 961722 ydjY Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288184.1 2508669 D 155864 CDS NP_288185.1 15802163 961723 2509523..2510230 1 NC_002655.2 hypothetical protein 2510230 ydjZ 961723 ydjZ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288185.1 2509523 D 155864 CDS NP_288186.1 15802164 961724 2510230..2510778 1 NC_002655.2 hypothetical protein 2510778 ynjA 961724 ynjA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288186.1 2510230 D 155864 CDS NP_288187.1 15802165 961725 2510785..2511954 1 NC_002655.2 ABC transporter substrate-binding protein 2511954 961725 Z2786 Escherichia coli O157:H7 str. EDL933 ABC transporter substrate-binding protein NP_288187.1 2510785 D 155864 CDS NP_288188.1 15802166 961726 2511972..2513462 1 NC_002655.2 transport system permease 2513462 961726 Z2787 Escherichia coli O157:H7 str. EDL933 transport system permease NP_288188.1 2511972 D 155864 CDS NP_288189.1 15802167 961727 2513462..2514115 1 NC_002655.2 ABC transporter ATP-binding protein 2514115 961727 Z2788 Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_288189.1 2513462 D 155864 CDS NP_288190.1 15802168 961728 2514167..2515489 1 NC_002655.2 thiosulfate sulfurtransferase 2515489 961728 Z2789 Escherichia coli O157:H7 str. EDL933 thiosulfate sulfurtransferase NP_288190.1 2514167 D 155864 CDS NP_288191.1 15802169 961729 complement(2515498..2516124) 1 NC_002655.2 cytochrome oxidase 2516124 961729 Z2790 Escherichia coli O157:H7 str. EDL933 cytochrome oxidase NP_288191.1 2515498 R 155864 CDS NP_288192.1 15802170 961730 2516205..2516612 1 NC_002655.2 pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase 2516612 961730 Z2791 Escherichia coli O157:H7 str. EDL933 pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase NP_288192.1 2516205 D 155864 CDS NP_288193.1 15802171 961731 complement(2516578..2516850) 1 NC_002655.2 hypothetical protein 2516850 961731 Z2792 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288193.1 2516578 R 155864 CDS NP_288194.1 15802172 961732 2517086..2518429 1 NC_002655.2 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 2518429 gdhA 961732 gdhA Escherichia coli O157:H7 str. EDL933 glutamate dehydrogenase NP_288194.1 2517086 D 155864 CDS NP_288195.1 15802173 961733 complement(2518546..2519430) 1 NC_002655.2 hypothetical protein 2519430 961733 Z2795 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288195.1 2518546 R 155864 CDS NP_288196.1 15802174 961734 complement(2519714..2521675) 1 NC_002655.2 decatenates replicating daughter chromosomes; DNA topoisomerase III 2521675 topB 961734 topB Escherichia coli O157:H7 str. EDL933 DNA topoisomerase III NP_288196.1 2519714 R 155864 CDS NP_288197.1 15802175 961735 complement(2521680..2522723) 1 NC_002655.2 catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase 2522723 selD 961735 selD Escherichia coli O157:H7 str. EDL933 selenophosphate synthetase NP_288197.1 2521680 R 155864 CDS NP_288198.1 15802176 961736 complement(2522840..2523391) 1 NC_002655.2 hypothetical protein 2523391 ydjA 961736 ydjA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288198.1 2522840 R 155864 CDS NP_288199.1 15802177 961737 2523552..2525408 1 NC_002655.2 SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane; protease 4 2525408 sppA 961737 sppA Escherichia coli O157:H7 str. EDL933 protease 4 NP_288199.1 2523552 D 155864 CDS NP_288200.1 15802178 961738 2525431..2526234 1 NC_002655.2 hypothetical protein 2526234 961738 Z2800 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288200.1 2525431 D 155864 CDS NP_288201.1 15802179 961739 2526366..2527382 1 NC_002655.2 converts asparagine to aspartate and ammonia; asparaginase 2527382 ansA 961739 ansA Escherichia coli O157:H7 str. EDL933 asparaginase NP_288201.1 2526366 D 155864 CDS NP_288202.2 161367596 961740 2527393..2528034 1 NC_002655.2 catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide; nicotinamidase/pyrazinamidase 2528034 ydjB 961740 ydjB Escherichia coli O157:H7 str. EDL933 nicotinamidase/pyrazinamidase NP_288202.2 2527393 D 155864 CDS NP_288203.1 15802181 961741 complement(2528127..2529377) 1 NC_002655.2 transporter 2529377 ydjE 961741 ydjE Escherichia coli O157:H7 str. EDL933 transporter NP_288203.1 2528127 R 155864 CDS NP_288204.1 15802182 961742 2529440..2529766 1 NC_002655.2 hypothetical protein 2529766 961742 Z2804 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288204.1 2529440 D 155864 CDS NP_288205.1 15802183 961743 2529766..2530653 1 NC_002655.2 transposase 2530653 961743 Z2806 Escherichia coli O157:H7 str. EDL933 transposase NP_288205.1 2529766 D 155864 CDS NP_288206.1 15802184 961744 complement(2530916..2531674) 1 NC_002655.2 DEOR-type transcriptional regulator 2531674 961744 Z2808 Escherichia coli O157:H7 str. EDL933 DEOR-type transcriptional regulator NP_288206.1 2530916 R 155864 CDS NP_288207.1 15802185 961745 complement(2531811..2532791) 1 NC_002655.2 hypothetical protein 2532791 961745 Z2809 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288207.1 2531811 R 155864 CDS NP_288208.1 15802186 961746 complement(2532801..2533733) 1 NC_002655.2 kinase 2533733 961746 Z2810 Escherichia coli O157:H7 str. EDL933 kinase NP_288208.1 2532801 R 155864 CDS NP_288209.1 15802187 961747 complement(2533738..2534574) 1 NC_002655.2 aldolase 2534574 961747 Z2811 Escherichia coli O157:H7 str. EDL933 aldolase NP_288209.1 2533738 R 155864 CDS NP_288210.1 15802188 961748 complement(2534595..2535638) 1 NC_002655.2 oxidoreductase 2535638 ydjJ 961748 ydjJ Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_288210.1 2534595 R 155864 CDS NP_288211.1 15802189 961749 complement(2535655..2537034) 1 NC_002655.2 transporter 2537034 961749 Z2813 Escherichia coli O157:H7 str. EDL933 transporter NP_288211.1 2535655 R 155864 CDS NP_288212.1 15802190 961750 complement(2537061..2538137) 1 NC_002655.2 oxidoreductase 2538137 961750 Z2815 Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_288212.1 2537061 R 155864 CDS NP_288213.1 15802191 961751 complement(2538507..2538824) 1 NC_002655.2 hypothetical protein 2538824 961751 Z2816 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288213.1 2538507 R 155864 CDS NP_288214.1 15802192 961752 complement(2538821..2539234) 1 NC_002655.2 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 2539234 yeaA 961752 yeaA Escherichia coli O157:H7 str. EDL933 methionine sulfoxide reductase B NP_288214.1 2538821 R 155864 CDS NP_288215.1 15802193 961753 2539576..2540571 1 NC_002655.2 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; glyceraldehyde-3-phosphate dehydrogenase 2540571 gapA 961753 gapA Escherichia coli O157:H7 str. EDL933 glyceraldehyde-3-phosphate dehydrogenase NP_288215.1 2539576 D 155864 CDS NP_288216.1 15802194 961754 2540634..2541539 1 NC_002655.2 hypothetical protein 2541539 yeaD 961754 yeaD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288216.1 2540634 D 155864 CDS NP_288217.1 15802195 961755 complement(2541590..2542444) 1 NC_002655.2 aldehyde reductase 2542444 961755 Z2821 Escherichia coli O157:H7 str. EDL933 aldehyde reductase NP_288217.1 2541590 R 155864 CDS NP_288218.1 15802196 961756 complement(2542534..2543280) 1 NC_002655.2 hypothetical protein 2543280 yeaF 961756 yeaF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288218.1 2542534 R 155864 CDS NP_288219.1 15802197 961757 2543716..2545650 1 NC_002655.2 hypothetical protein 2545650 yeaG 961757 yeaG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288219.1 2543716 D 155864 CDS NP_288220.1 15802198 961758 2545763..2547046 1 NC_002655.2 hypothetical protein 2547046 yeaH 961758 yeaH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288220.1 2545763 D 155864 CDS NP_288221.1 15802199 961759 2547334..2548668 1 NC_002655.2 hypothetical protein 2548668 yeaI 961759 yeaI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288221.1 2547334 D 155864 CDS NP_288222.1 15802200 961760 2548849..2550339 1 NC_002655.2 hypothetical protein 2550339 yeaJ 961760 yeaJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288222.1 2548849 D 155864 CDS NP_288223.1 15802201 961761 2550382..2550885 1 NC_002655.2 hypothetical protein 2550885 yeaK 961761 yeaK Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288223.1 2550382 D 155864 CDS NP_288224.1 15802202 961762 complement(2550886..2551038) 1 NC_002655.2 hypothetical protein 2551038 961762 Z2828 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288224.1 2550886 R 155864 CDS NP_288225.1 15802203 961763 2551160..2551606 1 NC_002655.2 hypothetical protein 2551606 yeaL 961763 yeaL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288225.1 2551160 D 155864 CDS NP_288226.1 15802204 961764 complement(2551563..2552384) 1 NC_002655.2 AraC family transcriptional regulator 2552384 yeaM 961764 yeaM Escherichia coli O157:H7 str. EDL933 AraC family transcriptional regulator NP_288226.1 2551563 R 155864 CDS NP_288227.1 15802205 961765 2552481..2553662 1 NC_002655.2 amino acid/amine transport protein 2553662 yeaN 961765 yeaN Escherichia coli O157:H7 str. EDL933 amino acid/amine transport protein NP_288227.1 2552481 D 155864 CDS NP_288228.2 228979047 961766 2553717..2554064 1 NC_002655.2 hypothetical protein 2554064 yeaO 961766 yeaO Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288228.2 2553717 D 155864 CDS NP_288229.1 15802207 961767 complement(2554086..2554340) 1 NC_002655.2 hypothetical protein 2554340 yoaF 961767 yoaF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288229.1 2554086 R 155864 CDS NP_288230.1 15804995 959645 2554523..2555548 1 NC_002655.2 diguanylate cyclase 2555548 959645 Z2836m Escherichia coli O157:H7 str. EDL933 diguanylate cyclase NP_288230.1 2554523 D 155864 CDS NP_288231.1 15802208 961768 complement(2555815..2556063) 1 NC_002655.2 hypothetical protein 2556063 yeaQ 961768 yeaQ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288231.1 2555815 R 155864 CDS NP_288232.1 15802209 961769 complement(2556210..2556392) 1 NC_002655.2 hypothetical protein 2556392 yoaG 961769 yoaG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288232.1 2556210 R 155864 CDS NP_288233.1 15802210 961770 complement(2556396..2556755) 1 NC_002655.2 hypothetical protein 2556755 yeaR 961770 yeaR Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288233.1 2556396 R 155864 CDS NP_288234.1 15802211 961771 complement(2556928..2557566) 1 NC_002655.2 leucine export protein LeuE 2557566 yeaS 961771 yeaS Escherichia coli O157:H7 str. EDL933 leucine export protein LeuE NP_288234.1 2556928 R 155864 CDS NP_288235.1 15802212 961772 complement(2557693..2558637) 1 NC_002655.2 LysR family transcriptional regulator 2558637 yeaT 961772 yeaT Escherichia coli O157:H7 str. EDL933 LysR family transcriptional regulator NP_288235.1 2557693 R 155864 CDS NP_288236.1 15802213 961773 2558719..2559804 1 NC_002655.2 tartrate dehydrogenase 2559804 yeaU 961773 yeaU Escherichia coli O157:H7 str. EDL933 tartrate dehydrogenase NP_288236.1 2558719 D 155864 CDS NP_288237.1 15802214 961774 2560220..2561665 1 NC_002655.2 member of the betaine, carnitine, choline transporter (BCCT) family; unknown function; transporter 2561665 yeaV 961774 yeaV Escherichia coli O157:H7 str. EDL933 transporter NP_288237.1 2560220 D 155864 CDS NP_288238.1 15802215 961775 2561697..2562821 1 NC_002655.2 hypothetical protein 2562821 yeaW 961775 yeaW Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288238.1 2561697 D 155864 CDS NP_288239.1 15802216 961776 2562877..2563842 1 NC_002655.2 diogenase subunit beta 2563842 yeaX 961776 yeaX Escherichia coli O157:H7 str. EDL933 diogenase subunit beta NP_288239.1 2562877 D 155864 CDS NP_288240.1 15802217 961777 complement(2563897..2565024) 1 NC_002655.2 ribonuclease D 2565024 rnd 961777 rnd Escherichia coli O157:H7 str. EDL933 ribonuclease D NP_288240.1 2563897 R 155864 CDS NP_288241.1 15802218 961778 complement(2565094..2566779) 1 NC_002655.2 Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 2566779 fadD 961778 fadD Escherichia coli O157:H7 str. EDL933 long-chain-fatty-acid--CoA ligase NP_288241.1 2565094 R 155864 CDS NP_288242.1 15802219 961779 complement(2566984..2567565) 1 NC_002655.2 hypothetical protein 2567565 961779 Z2849 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288242.1 2566984 R 155864 CDS NP_288243.1 15802220 961780 complement(2567605..2568300) 1 NC_002655.2 hypothetical protein 2568300 yeaZ 961780 yeaZ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288243.1 2567605 R 155864 CDS NP_288244.1 15802221 961781 complement(2568358..2570268) 1 NC_002655.2 hypothetical protein 2570268 961781 Z2851 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288244.1 2568358 R 155864 CDS NP_288245.1 15802222 961782 2570352..2570744 1 NC_002655.2 hypothetical protein 2570744 961782 Z2852 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288245.1 2570352 D 155864 CDS NP_288246.1 15802223 961783 2571106..2571465 1 NC_002655.2 hypothetical protein 2571465 961783 Z2853 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288246.1 2571106 D 155864 CDS NP_288247.1 15802224 961784 complement(2571585..2571764) 1 NC_002655.2 hypothetical protein 2571764 961784 Z2854 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288247.1 2571585 R 155864 CDS NP_288248.1 15802225 961785 2571838..2573199 1 NC_002655.2 catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine; para-aminobenzoate synthase component I 2573199 pabB 961785 pabB Escherichia coli O157:H7 str. EDL933 para-aminobenzoate synthase component I NP_288248.1 2571838 D 155864 CDS NP_288249.1 15802226 961786 2573203..2573781 1 NC_002655.2 hypothetical protein 2573781 yeaB 961786 yeaB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288249.1 2573203 D 155864 CDS NP_288250.1 15802227 961787 2573965..2575329 1 NC_002655.2 L-serine dehydratase 1 2575329 sdaA 961787 sdaA Escherichia coli O157:H7 str. EDL933 L-serine dehydratase 1 NP_288250.1 2573965 D 155864 CDS NP_288251.1 15802228 961788 2575430..2577058 1 NC_002655.2 hypothetical protein 2577058 961788 Z2858 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288251.1 2575430 D 155864 CDS NP_288252.1 15802229 961789 complement(2577062..2578618) 1 NC_002655.2 transporter 2578618 yoaE 961789 yoaE Escherichia coli O157:H7 str. EDL933 transporter NP_288252.1 2577062 R 155864 CDS NP_288253.1 15802230 961790 2579083..2580054 1 NC_002655.2 PTS system mannose-specific transporter subunit IIAB 2580054 manX 961790 manX Escherichia coli O157:H7 str. EDL933 PTS system mannose-specific transporter subunit IIAB NP_288253.1 2579083 D 155864 CDS NP_288254.1 15802231 961791 2580117..2580917 1 NC_002655.2 PTS enzyme IIC, mannose-specific 2580917 manY 961791 manY Escherichia coli O157:H7 str. EDL933 PTS enzyme IIC, mannose-specific NP_288254.1 2580117 D 155864 CDS NP_288255.1 15802232 961792 2580921..2581781 1 NC_002655.2 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; PTS system mannose-specific transporter subunit IID 2581781 manZ 961792 manZ Escherichia coli O157:H7 str. EDL933 PTS system mannose-specific transporter subunit IID NP_288255.1 2580921 D 155864 CDS NP_288256.1 15802233 961793 2581836..2582294 1 NC_002655.2 hypothetical protein 2582294 961793 Z2863 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288256.1 2581836 D 155864 CDS NP_288257.1 15802234 961794 2582670..2583290 1 NC_002655.2 membrane protein YebN; hypothetical protein 2583290 961794 Z2864 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288257.1 2582670 D 155864 CDS NP_288258.1 15802235 961795 complement(2583287..2584096) 1 NC_002655.2 methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth; 23S rRNA methyltransferase 2584096 rrmA 961795 rrmA Escherichia coli O157:H7 str. EDL933 23S rRNA methyltransferase NP_288258.1 2583287 R 155864 CDS NP_288259.1 15802236 961796 complement(2584262..2584471) 1 NC_002655.2 cold shock-like protein CspC 2584471 cspC 961796 cspC Escherichia coli O157:H7 str. EDL933 cold shock-like protein CspC NP_288259.1 2584262 R 155864 CDS NP_288260.1 15802237 961797 complement(2584484..2584627) 1 NC_002655.2 hypothetical protein 2584627 961797 Z2869 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288260.1 2584484 R 155864 CDS NP_288261.1 15802238 961798 complement(2585296..2585583) 1 NC_002655.2 hypothetical protein 2585583 961798 Z2871 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288261.1 2585296 R 155864 CDS NP_288262.1 15802239 961799 complement(2585658..2585801) 1 NC_002655.2 hypothetical protein 2585801 961799 Z2872 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288262.1 2585658 R 155864 CDS NP_288263.1 15802240 961800 2585961..2586200 1 NC_002655.2 No significant matches; hypothetical protein 2586200 961800 Z2873 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288263.1 2585961 D 155864 CDS NP_288264.1 15802241 961801 complement(2586345..2587136) 1 NC_002655.2 regulator 2587136 961801 Z2874 Escherichia coli O157:H7 str. EDL933 regulator NP_288264.1 2586345 R 155864 CDS NP_288265.1 15802242 961802 2587202..2588686 1 NC_002655.2 transporter 2588686 961802 Z2875 Escherichia coli O157:H7 str. EDL933 transporter NP_288265.1 2587202 D 155864 CDS NP_288266.1 15802243 961803 complement(2588732..2589613) 1 NC_002655.2 metalloprotease; heat shock protein HtpX 2589613 htpX 961803 htpX Escherichia coli O157:H7 str. EDL933 heat shock protein HtpX NP_288266.1 2588732 R 155864 CDS NP_288267.1 15802244 961804 complement(2589805..2591853) 1 NC_002655.2 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease 2591853 prc 961804 prc Escherichia coli O157:H7 str. EDL933 carboxy-terminal protease NP_288267.1 2589805 R 155864 CDS NP_288268.1 15804984 959633 complement(2591873..2592571) 1 NC_002655.2 affects solute and DNA transport through an unknown mechanism; solute/DNA competence effector 2592571 proQ 959633 proQ Escherichia coli O157:H7 str. EDL933 solute/DNA competence effector NP_288268.1 2591873 R 155864 CDS NP_288269.1 15802245 961805 complement(2592668..2593219) 1 NC_002655.2 hypothetical protein 2593219 961805 Z2879 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288269.1 2592668 R 155864 CDS NP_288270.1 15802246 961806 2593295..2594578 1 NC_002655.2 hypothetical protein 2594578 961806 Z2880 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288270.1 2593295 D 155864 CDS NP_288271.1 15802247 961807 2594541..2597180 1 NC_002655.2 hypothetical protein 2597180 961807 Z2881 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288271.1 2594541 D 155864 CDS NP_288272.1 15802248 961808 2597255..2598700 1 NC_002655.2 in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA; rRNA (cytosine-C(5)-)-methyltransferase RsmF 2598700 yebU 961808 yebU Escherichia coli O157:H7 str. EDL933 rRNA (cytosine-C(5)-)-methyltransferase RsmF NP_288272.1 2597255 D 155864 CDS NP_288273.1 15802249 961809 2598803..2599054 1 NC_002655.2 hypothetical protein 2599054 961809 Z2883 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288273.1 2598803 D 155864 CDS NP_288274.1 15802250 961810 2599075..2599350 1 NC_002655.2 hypothetical protein 2599350 961810 Z2884 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288274.1 2599075 D 155864 CDS NP_288275.1 15802251 961811 complement(2599351..2600010) 1 NC_002655.2 Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins; serine/threonine protein phosphatase 1 2600010 pphA 961811 pphA Escherichia coli O157:H7 str. EDL933 serine/threonine protein phosphatase 1 NP_288275.1 2599351 R 155864 CDS NP_288276.1 15802252 961812 complement(2600403..2600744) 1 NC_002655.2 hypothetical protein 2600744 961812 Z2887 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288276.1 2600403 R 155864 CDS NP_288277.1 15802253 961813 complement(2600757..2601629) 1 NC_002655.2 resistance protein 2601629 961813 Z2888 Escherichia coli O157:H7 str. EDL933 resistance protein NP_288277.1 2600757 R 155864 CDS NP_288278.1 15802254 961814 complement(2601633..2602007) 1 NC_002655.2 hypothetical protein 2602007 961814 Z2889 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288278.1 2601633 R 155864 CDS NP_288279.1 15802255 961815 2602146..2602376 1 NC_002655.2 DNA polymerase III subunit theta 2602376 holE 961815 holE Escherichia coli O157:H7 str. EDL933 DNA polymerase III subunit theta NP_288279.1 2602146 D 155864 CDS NP_288280.1 15802256 961816 2602478..2603134 1 NC_002655.2 hypothetical protein 2603134 961816 Z2893 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288280.1 2602478 D 155864 CDS NP_288281.1 15802257 961817 2603158..2603820 1 NC_002655.2 3'-5' exonuclease activity on single or double-strand DNA; exodeoxyribonuclease X 2603820 961817 Z2894 Escherichia coli O157:H7 str. EDL933 exodeoxyribonuclease X NP_288281.1 2603158 D 155864 CDS NP_288282.1 15802258 961818 complement(2603817..2605877) 1 NC_002655.2 PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues; protease 2 2605877 ptrB 961818 ptrB Escherichia coli O157:H7 str. EDL933 protease 2 NP_288282.1 2603817 R 155864 CDS NP_288283.1 15802259 961819 complement(2606086..2606745) 1 NC_002655.2 hypothetical protein 2606745 yebE 961819 yebE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288283.1 2606086 R 155864 CDS NP_288284.1 15802260 961820 complement(2607073..2607441) 1 NC_002655.2 secreted protein; unknown function; hypothetical protein 2607441 yebF 961820 yebF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288284.1 2607073 R 155864 CDS NP_288285.1 15802261 961821 complement(2607496..2607786) 1 NC_002655.2 DNA damage-inducible protein YebG 2607786 yebG 961821 yebG Escherichia coli O157:H7 str. EDL933 DNA damage-inducible protein YebG NP_288285.1 2607496 R 155864 CDS NP_288286.1 15802262 961822 2607920..2609098 1 NC_002655.2 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 2609098 purT 961822 purT Escherichia coli O157:H7 str. EDL933 phosphoribosylglycinamide formyltransferase 2 NP_288286.1 2607920 D 155864 CDS NP_288287.1 15802263 961823 complement(2609154..2609795) 1 NC_002655.2 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 2609795 eda 961823 eda Escherichia coli O157:H7 str. EDL933 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase NP_288287.1 2609154 R 155864 CDS NP_288288.1 15802264 961824 complement(2609832..2611643) 1 NC_002655.2 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase 2611643 edd 961824 edd Escherichia coli O157:H7 str. EDL933 phosphogluconate dehydratase NP_288288.1 2609832 R 155864 CDS NP_288289.1 15802265 961825 complement(2611878..2613353) 1 NC_002655.2 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 2613353 zwf 961825 zwf Escherichia coli O157:H7 str. EDL933 glucose-6-phosphate 1-dehydrogenase NP_288289.1 2611878 R 155864 CDS NP_288290.1 15802266 961826 2613691..2614560 1 NC_002655.2 Represses the expression of the zwf, eda, glp and gap; DNA-binding transcriptional regulator HexR 2614560 yebK 961826 yebK Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator HexR NP_288290.1 2613691 D 155864 CDS NP_288291.1 15802267 961827 2614688..2616130 1 NC_002655.2 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 2616130 pykA 961827 pykA Escherichia coli O157:H7 str. EDL933 pyruvate kinase NP_288291.1 2614688 D 155864 CDS NP_288292.1 15802268 961828 complement(2616261..2617232) 1 NC_002655.2 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 2617232 msbB 961828 msbB Escherichia coli O157:H7 str. EDL933 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase NP_288292.1 2616261 R 155864 CDS NP_288293.2 161367595 961829 complement(2617352..2618674) 1 NC_002655.2 hypothetical protein 2618674 yebA 961829 yebA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288293.2 2617352 R 155864 CDS NP_288294.2 161367594 961830 complement(2618690..2619622) 1 NC_002655.2 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter periplasmic protein 2619622 znuA 961830 znuA Escherichia coli O157:H7 str. EDL933 high-affinity zinc transporter periplasmic protein NP_288294.2 2618690 R 155864 CDS NP_288295.1 15802271 961831 2619701..2620456 1 NC_002655.2 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter ATPase 2620456 znuC 961831 znuC Escherichia coli O157:H7 str. EDL933 high-affinity zinc transporter ATPase NP_288295.1 2619701 D 155864 CDS NP_288296.1 15802272 961832 2620453..2621238 1 NC_002655.2 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter membrane protein 2621238 znuB 961832 znuB Escherichia coli O157:H7 str. EDL933 high-affinity zinc transporter membrane protein NP_288296.1 2620453 D 155864 CDS NP_288297.1 15802273 961833 complement(2621484..2622494) 1 NC_002655.2 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 2622494 ruvB 961833 ruvB Escherichia coli O157:H7 str. EDL933 Holliday junction DNA helicase RuvB NP_288297.1 2621484 R 155864 CDS NP_288298.1 15802274 961834 complement(2622503..2623114) 1 NC_002655.2 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 2623114 ruvA 961834 ruvA Escherichia coli O157:H7 str. EDL933 Holliday junction DNA helicase RuvA NP_288298.1 2622503 R 155864 CDS NP_288299.2 161367593 961835 2623389..2623991 1 NC_002655.2 hypothetical protein 2623991 yebB 961835 yebB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288299.2 2623389 D 155864 CDS NP_288300.1 15802276 961836 complement(2623993..2624514) 1 NC_002655.2 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 2624514 ruvC 961836 ruvC Escherichia coli O157:H7 str. EDL933 Holliday junction resolvase NP_288300.1 2623993 R 155864 CDS NP_288301.1 15802277 961837 complement(2624549..2625289) 1 NC_002655.2 hypothetical protein 2625289 yebC 961837 yebC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288301.1 2624549 R 155864 CDS NP_288302.1 15802278 961838 complement(2625318..2625770) 1 NC_002655.2 converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase 2625770 ntpA 961838 ntpA Escherichia coli O157:H7 str. EDL933 dATP pyrophosphohydrolase NP_288302.1 2625318 R 155864 CDS NP_288303.1 15802279 961839 complement(2625888..2627660) 1 NC_002655.2 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 2627660 aspS 961839 aspS Escherichia coli O157:H7 str. EDL933 aspartyl-tRNA synthetase NP_288303.1 2625888 R 155864 CDS NP_288304.2 161367592 961840 2627970..2628536 1 NC_002655.2 hypothetical protein 2628536 yecD 961840 yecD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288304.2 2627970 D 155864 CDS NP_288305.1 15802281 961841 2628533..2629351 1 NC_002655.2 hypothetical protein 2629351 yecE 961841 yecE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288305.1 2628533 D 155864 CDS NP_288306.2 161367591 961842 2629404..2629799 1 NC_002655.2 hypothetical protein 2629799 yecN 961842 yecN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288306.2 2629404 D 155864 CDS NP_288307.1 15802283 961843 2629840..2630583 1 NC_002655.2 hypothetical protein 2630583 yecO 961843 yecO Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288307.1 2629840 D 155864 CDS NP_288308.1 15802284 961844 2630580..2631551 1 NC_002655.2 hypothetical protein 2631551 yecP 961844 yecP Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288308.1 2630580 D 155864 CDS NP_288309.1 15802285 961845 complement(2631716..2634163) 1 NC_002655.2 biotin sulfoxide reductase 2634163 bisZ 961845 bisZ Escherichia coli O157:H7 str. EDL933 biotin sulfoxide reductase NP_288309.1 2631716 R 155864 CDS NP_288310.1 15802286 961846 complement(2634170..2635270) 1 NC_002655.2 cytochrome C 2635270 yecK 961846 yecK Escherichia coli O157:H7 str. EDL933 cytochrome C NP_288310.1 2634170 R 155864 CDS NP_288311.1 15804982 959636 complement(2635661..2636407) 1 NC_002655.2 copper homeostasis protein CutC 2636407 cutC 959636 cutC Escherichia coli O157:H7 str. EDL933 copper homeostasis protein CutC NP_288311.1 2635661 R 155864 CDS NP_288312.1 15802287 961847 complement(2636421..2636993) 1 NC_002655.2 hypothetical protein 2636993 yecM 961847 yecM Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288312.1 2636421 R 155864 CDS NP_288313.1 15802288 961848 2637203..2638936 1 NC_002655.2 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 2638936 argS 961848 argS Escherichia coli O157:H7 str. EDL933 arginyl-tRNA synthetase NP_288313.1 2637203 D 155864 CDS NP_288314.1 15802289 961849 2639113..2639601 1 NC_002655.2 hypothetical protein 2639601 yecT 961849 yecT Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288314.1 2639113 D 155864 CDS NP_288315.1 15802290 961850 complement(2639721..2640113) 1 NC_002655.2 flagellar protein 2640113 flhE 961850 flhE Escherichia coli O157:H7 str. EDL933 flagellar protein NP_288315.1 2639721 R 155864 CDS NP_288316.1 15802291 961851 complement(2640113..2642191) 1 NC_002655.2 membrane protein involved in the flagellar export apparatus; flagellar biosynthesis protein FlhA 2642191 flhA 961851 flhA Escherichia coli O157:H7 str. EDL933 flagellar biosynthesis protein FlhA NP_288316.1 2640113 R 155864 CDS NP_288317.1 15802292 961852 complement(2642184..2643332) 1 NC_002655.2 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; flagellar biosynthesis protein FlhB 2643332 flhB 961852 flhB Escherichia coli O157:H7 str. EDL933 flagellar biosynthesis protein FlhB NP_288317.1 2642184 R 155864 CDS NP_288318.1 15802293 961853 complement(2643534..2644178) 1 NC_002655.2 cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation; chemotaxis regulator CheZ 2644178 cheZ 961853 cheZ Escherichia coli O157:H7 str. EDL933 chemotaxis regulator CheZ NP_288318.1 2643534 R 155864 CDS NP_288319.1 15802294 961854 complement(2644189..2644578) 1 NC_002655.2 chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble; chemotaxis regulatory protein CheY 2644578 cheY 961854 cheY Escherichia coli O157:H7 str. EDL933 chemotaxis regulatory protein CheY NP_288319.1 2644189 R 155864 CDS NP_288320.1 15802295 961855 complement(2644593..2645642) 1 NC_002655.2 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins; chemotaxis-specific methylesterase 2645642 cheB 961855 cheB Escherichia coli O157:H7 str. EDL933 chemotaxis-specific methylesterase NP_288320.1 2644593 R 155864 CDS NP_288321.1 15802296 961856 complement(2645645..2646505) 1 NC_002655.2 methylates the MCP; chemotaxis methyltransferase CheR 2646505 cheR 961856 cheR Escherichia coli O157:H7 str. EDL933 chemotaxis methyltransferase CheR NP_288321.1 2645645 R 155864 CDS NP_288322.1 15802297 961857 complement(2646524..2648125) 1 NC_002655.2 mediates taxis toward dipeptides; methyl-accepting protein IV 2648125 tap 961857 tap Escherichia coli O157:H7 str. EDL933 methyl-accepting protein IV NP_288322.1 2646524 R 155864 CDS NP_288323.1 15802298 961858 complement(2648171..2649832) 1 NC_002655.2 methyl-accepting chemotaxis protein II 2649832 tar 961858 tar Escherichia coli O157:H7 str. EDL933 methyl-accepting chemotaxis protein II NP_288323.1 2648171 R 155864 CDS NP_288324.1 15802299 961859 complement(2649975..2650478) 1 NC_002655.2 purine-binding chemotaxis protein 2650478 cheW 961859 cheW Escherichia coli O157:H7 str. EDL933 purine-binding chemotaxis protein NP_288324.1 2649975 R 155864 CDS NP_288325.1 15802300 961860 complement(2650499..2652463) 1 NC_002655.2 chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component; chemotaxis protein CheA 2652463 cheA 961860 cheA Escherichia coli O157:H7 str. EDL933 chemotaxis protein CheA NP_288325.1 2650499 R 155864 CDS NP_288326.1 15802301 961861 complement(2652468..2653394) 1 NC_002655.2 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotB 2653394 motB 961861 motB Escherichia coli O157:H7 str. EDL933 flagellar motor protein MotB NP_288326.1 2652468 R 155864 CDS NP_288327.1 15802302 961862 complement(2653391..2654278) 1 NC_002655.2 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotA 2654278 motA 961862 motA Escherichia coli O157:H7 str. EDL933 flagellar motor protein MotA NP_288327.1 2653391 R 155864 CDS NP_288328.1 15802303 961863 complement(2654405..2654983) 1 NC_002655.2 With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems; transcriptional activator FlhC 2654983 flhC 961863 flhC Escherichia coli O157:H7 str. EDL933 transcriptional activator FlhC NP_288328.1 2654405 R 155864 CDS NP_288329.1 15802304 961864 complement(2654986..2655345) 1 NC_002655.2 with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems; transcriptional activator FlhD 2655345 flhD 961864 flhD Escherichia coli O157:H7 str. EDL933 transcriptional activator FlhD NP_288329.1 2654986 R 155864 CDS NP_288331.1 15802306 961866 2656116..2656544 1 NC_002655.2 ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspC 2656544 yecG 961866 yecG Escherichia coli O157:H7 str. EDL933 universal stress protein UspC NP_288331.1 2656116 D 155864 CDS NP_288332.1 15802307 961867 complement(2656551..2657975) 1 NC_002655.2 trehalose-6-phosphate synthase 2657975 otsA 961867 otsA Escherichia coli O157:H7 str. EDL933 trehalose-6-phosphate synthase NP_288332.1 2656551 R 155864 CDS NP_288333.1 15802308 961868 complement(2657950..2658750) 1 NC_002655.2 biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature; trehalose-6-phosphate phosphatase 2658750 otsB 961868 otsB Escherichia coli O157:H7 str. EDL933 trehalose-6-phosphate phosphatase NP_288333.1 2657950 R 155864 CDS NP_288334.1 15804999 959637 complement(2658917..2659906) 1 NC_002655.2 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter permease 2659906 araH 959637 araH Escherichia coli O157:H7 str. EDL933 L-arabinose transporter permease NP_288334.1 2658917 R 155864 CDS NP_288335.1 15802309 961869 complement(2659918..2661432) 1 NC_002655.2 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter ATP-binding protein 2661432 araG 961869 araG Escherichia coli O157:H7 str. EDL933 L-arabinose transporter ATP-binding protein NP_288335.1 2659918 R 155864 CDS NP_288336.1 15802310 961870 complement(2661502..2662491) 1 NC_002655.2 L-arabinose-binding periplasmic protein 2662491 araF 961870 araF Escherichia coli O157:H7 str. EDL933 L-arabinose-binding periplasmic protein NP_288336.1 2661502 R 155864 CDS NP_288337.1 15802311 961871 2663288..2663791 1 NC_002655.2 ferritin 2663791 yecI 961871 yecI Escherichia coli O157:H7 str. EDL933 ferritin NP_288337.1 2663288 D 155864 CDS NP_288339.1 15802313 961873 2664585..2664908 1 NC_002655.2 hypothetical protein 2664908 961873 Z2959 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288339.1 2664585 D 155864 CDS NP_288340.1 15802314 961874 2665079..2665576 1 NC_002655.2 cytoplasmic iron storage protein; ferritin 2665576 ftn 961874 ftn Escherichia coli O157:H7 str. EDL933 ferritin NP_288340.1 2665079 D 155864 CDS NP_288341.1 15802315 961875 complement(2665613..2665852) 1 NC_002655.2 hypothetical protein 2665852 yecH 961875 yecH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288341.1 2665613 R 155864 CDS NP_288342.1 15802316 961876 2666044..2667255 1 NC_002655.2 tyrosine-specific transporter 2667255 tyrP 961876 tyrP Escherichia coli O157:H7 str. EDL933 tyrosine-specific transporter NP_288342.1 2666044 D 155864 CDS NP_288343.1 15802317 961877 complement(2667317..2667982) 1 NC_002655.2 hypothetical protein 2667982 yecA 961877 yecA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288343.1 2667317 R 155864 CDS NP_288344.1 15802318 961878 complement(2668339..2669340) 1 NC_002655.2 integrase for prophage CP-933T 2669340 intT 961878 intT Escherichia coli O157:H7 str. EDL933 integrase for prophage CP-933T NP_288344.1 2668339 R 155864 CDS NP_288345.1 15802319 961879 complement(2669346..2669693) 1 NC_002655.2 No significant matches; hypothetical protein 2669693 961879 Z2967 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288345.1 2669346 R 155864 CDS NP_288346.1 15802320 961880 complement(2669723..2670373) 1 NC_002655.2 No significant matches; hypothetical protein 2670373 961880 Z2968 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288346.1 2669723 R 155864 CDS NP_288347.1 15802321 961881 complement(2670389..2670793) 1 NC_002655.2 hypothetical protein 2670793 961881 Z2969 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288347.1 2670389 R 155864 CDS NP_288348.1 15802322 961882 2671092..2671295 1 NC_002655.2 regulator for prophage CP-933T 2671295 coxT 961882 coxT Escherichia coli O157:H7 str. EDL933 regulator for prophage CP-933T NP_288348.1 2671092 D 155864 CDS NP_288349.1 15802323 961883 2671317..2671667 1 NC_002655.2 No significant matches; hypothetical protein 2671667 961883 Z2971 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288349.1 2671317 D 155864 CDS NP_288350.1 15802324 961884 2671678..2671956 1 NC_002655.2 No significant matches; hypothetical protein 2671956 961884 Z2972 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288350.1 2671678 D 155864 CDS NP_288351.1 15802325 961885 2671968..2672210 1 NC_002655.2 No significant matches; hypothetical protein 2672210 961885 Z2973 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288351.1 2671968 D 155864 CDS NP_288352.1 15802326 961886 2672413..2672829 1 NC_002655.2 No significant matches; hypothetical protein 2672829 961886 Z2974 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288352.1 2672413 D 155864 CDS NP_288353.1 15802327 961887 2673316..2673615 1 NC_002655.2 No significant matches; hypothetical protein 2673615 961887 Z2975 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288353.1 2673316 D 155864 CDS NP_288354.1 15802328 961888 2673938..2674168 1 NC_002655.2 No significant matches; hypothetical protein 2674168 961888 Z2976 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288354.1 2673938 D 155864 CDS NP_288355.1 15802329 961889 2674241..2674606 1 NC_002655.2 No significant matches; hypothetical protein 2674606 961889 Z2977 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288355.1 2674241 D 155864 CDS NP_288356.1 15802330 961890 2674613..2677435 1 NC_002655.2 replication protein for prophage CP-933T 2677435 961890 Z2978 Escherichia coli O157:H7 str. EDL933 replication protein for prophage CP-933T NP_288356.1 2674613 D 155864 CDS NP_288357.1 15802331 961891 2677512..2678471 1 NC_002655.2 stability/partitioning protein encoded within prophage CP-933T 2678471 961891 Z2979 Escherichia coli O157:H7 str. EDL933 stability/partitioning protein encoded within prophage CP-933T NP_288357.1 2677512 D 155864 CDS NP_288358.1 15802332 961892 2678476..2678790 1 NC_002655.2 stability/partitioning protein encoded within CP-933T 2678790 961892 Z2980 Escherichia coli O157:H7 str. EDL933 stability/partitioning protein encoded within CP-933T NP_288358.1 2678476 D 155864 CDS NP_288359.1 15802333 961893 complement(2678810..2679499) 1 NC_002655.2 IS629 transposase encoded within prophage CP-933T 2679499 961893 Z2981 Escherichia coli O157:H7 str. EDL933 IS629 transposase encoded within prophage CP-933T NP_288359.1 2678810 R 155864 CDS NP_288360.1 15802334 961894 complement(2679499..2679825) 1 NC_002655.2 prophage-associated protein 2679825 961894 Z2982 Escherichia coli O157:H7 str. EDL933 prophage-associated protein NP_288360.1 2679499 R 155864 CDS NP_288361.1 15802335 961895 2679996..2680412 1 NC_002655.2 tail fiber assembly protein of prophage CP-933T 2680412 961895 Z2983 Escherichia coli O157:H7 str. EDL933 tail fiber assembly protein of prophage CP-933T NP_288361.1 2679996 D 155864 CDS NP_288362.1 15802336 961896 complement(2680456..2681061) 1 NC_002655.2 serine acetlyltransferase of prophage CP-933T 2681061 961896 Z2984 Escherichia coli O157:H7 str. EDL933 serine acetlyltransferase of prophage CP-933T NP_288362.1 2680456 R 155864 CDS NP_288363.1 15802337 961897 complement(2681185..2681679) 1 NC_002655.2 tail fiber protein of prophage CP-933T 2681679 961897 Z2985 Escherichia coli O157:H7 str. EDL933 tail fiber protein of prophage CP-933T NP_288363.1 2681185 R 155864 CDS NP_288364.1 15802338 961898 complement(2681686..2682522) 1 NC_002655.2 tail fiber protein of prophage CP-933T 2682522 961898 Z2986 Escherichia coli O157:H7 str. EDL933 tail fiber protein of prophage CP-933T NP_288364.1 2681686 R 155864 CDS NP_288365.1 15802339 961899 complement(2682399..2684489) 1 NC_002655.2 tail fiber component of prophage CP-933T 2684489 961899 Z2987 Escherichia coli O157:H7 str. EDL933 tail fiber component of prophage CP-933T NP_288365.1 2682399 R 155864 CDS NP_288366.1 15802340 961900 complement(2684476..2684631) 1 NC_002655.2 tail fiber protein component of prophage CP-933T 2684631 961900 Z2988 Escherichia coli O157:H7 str. EDL933 tail fiber protein component of prophage CP-933T NP_288366.1 2684476 R 155864 CDS NP_288367.1 15802341 961901 complement(2684640..2685005) 1 NC_002655.2 hypothetical protein 2685005 961901 Z2989 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288367.1 2684640 R 155864 CDS NP_288368.1 15802342 961902 complement(2685060..2685572) 1 NC_002655.2 tail fiber component of prophage CP-933T 2685572 961902 Z2990 Escherichia coli O157:H7 str. EDL933 tail fiber component of prophage CP-933T NP_288368.1 2685060 R 155864 CDS NP_288369.1 15802343 961903 complement(2685572..2686756) 1 NC_002655.2 tail sheath protein of prophage CP-933T 2686756 961903 Z2991 Escherichia coli O157:H7 str. EDL933 tail sheath protein of prophage CP-933T NP_288369.1 2685572 R 155864 CDS NP_288370.1 15802344 961904 2686884..2687237 1 NC_002655.2 tail assembly protein of prophage CP-933T 2687237 961904 Z2992 Escherichia coli O157:H7 str. EDL933 tail assembly protein of prophage CP-933T NP_288370.1 2686884 D 155864 CDS NP_288371.1 15802345 961905 complement(2687188..2688378) 1 NC_002655.2 IS30 transposase encoded within prophage CP-933T 2688378 tra8_2 961905 tra8_2 Escherichia coli O157:H7 str. EDL933 IS30 transposase encoded within prophage CP-933T NP_288371.1 2687188 R 155864 CDS NP_288372.1 15802346 961906 complement(2688478..2688870) 1 NC_002655.2 No significant matches; hypothetical protein 2688870 961906 Z2994 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288372.1 2688478 R 155864 CDS NP_288373.1 15802347 961910 complement(2689751..2690299) 1 NC_002655.2 phosphatidylglycerophosphate synthetase 2690299 pgsA 961910 pgsA Escherichia coli O157:H7 str. EDL933 phosphatidylglycerophosphate synthetase NP_288373.1 2689751 R 155864 CDS NP_288374.2 161367590 961911 complement(2690356..2692188) 1 NC_002655.2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 2692188 uvrC 961911 uvrC Escherichia coli O157:H7 str. EDL933 excinuclease ABC subunit C NP_288374.2 2690356 R 155864 CDS NP_288375.1 15802349 961912 complement(2692185..2692841) 1 NC_002655.2 in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system; response regulator 2692841 uvrY 961912 uvrY Escherichia coli O157:H7 str. EDL933 response regulator NP_288375.1 2692185 R 155864 CDS NP_288376.1 15802350 961913 2693300..2693524 1 NC_002655.2 hypothetical protein 2693524 yecF 961913 yecF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288376.1 2693300 D 155864 CDS NP_288377.1 15802351 961914 complement(2693592..2694314) 1 NC_002655.2 regulates genes involved in cell division; DNA-binding transcriptional activator SdiA 2694314 sdiA 961914 sdiA Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional activator SdiA NP_288377.1 2693592 R 155864 CDS NP_288378.1 15802352 961915 complement(2694544..2695296) 1 NC_002655.2 amino-acid ABC transporter ATP-binding protein YecC 2695296 yecC 961915 yecC Escherichia coli O157:H7 str. EDL933 amino-acid ABC transporter ATP-binding protein YecC NP_288378.1 2694544 R 155864 CDS NP_288379.1 15802353 961916 complement(2695293..2695961) 1 NC_002655.2 transport system permease 2695961 yecS 961916 yecS Escherichia coli O157:H7 str. EDL933 transport system permease NP_288379.1 2695293 R 155864 CDS NP_288380.2 161367589 961917 complement(2695976..2696962) 1 NC_002655.2 catalyzes the formation of pyruvate from D-cysteine; D-cysteine desulfhydrase 2696962 yedO 961917 yedO Escherichia coli O157:H7 str. EDL933 D-cysteine desulfhydrase NP_288380.2 2695976 R 155864 CDS NP_288381.1 15802355 961918 complement(2697067..2697867) 1 NC_002655.2 cystine transporter subunit 2697867 fliY 961918 fliY Escherichia coli O157:H7 str. EDL933 cystine transporter subunit NP_288381.1 2697067 R 155864 CDS NP_288382.1 15802356 961919 complement(2697955..2698542) 1 NC_002655.2 expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence; flagella biosynthesis protein FliZ 2698542 fliZ 961919 fliZ Escherichia coli O157:H7 str. EDL933 flagella biosynthesis protein FliZ NP_288382.1 2697955 R 155864 CDS NP_288383.1 15802357 961920 complement(2698552..2699271) 1 NC_002655.2 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes; flagellar biosynthesis sigma factor 2699271 fliA 961920 fliA Escherichia coli O157:H7 str. EDL933 flagellar biosynthesis sigma factor NP_288383.1 2698552 R 155864 CDS NP_288384.1 15802358 961921 complement(2699591..2701348) 1 NC_002655.2 structural flagella protein; individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes; flagellin 2701348 fliC 961921 fliC Escherichia coli O157:H7 str. EDL933 flagellin NP_288384.1 2699591 R 155864 CDS NP_288385.1 15802359 961922 2701614..2703011 1 NC_002655.2 involved in flagellin assembly; flagellar capping protein 2703011 fliD 961922 fliD Escherichia coli O157:H7 str. EDL933 flagellar capping protein NP_288385.1 2701614 D 155864 CDS NP_288386.1 15802360 961923 2703036..2703446 1 NC_002655.2 flagellin specific chaperone; flagellar protein FliS 2703446 fliS 961923 fliS Escherichia coli O157:H7 str. EDL933 flagellar protein FliS NP_288386.1 2703036 D 155864 CDS NP_288387.1 15802361 961925 2703446..2703811 1 NC_002655.2 binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family; flagellar biosynthesis protein FliT 2703811 fliT 961925 fliT Escherichia coli O157:H7 str. EDL933 flagellar biosynthesis protein FliT NP_288387.1 2703446 D 155864 CDS NP_288388.1 15802362 961926 2703889..2705376 1 NC_002655.2 converts 1,4-alpha-D-glucans to maltodextrin; alpha-amylase 2705376 amyA 961926 amyA Escherichia coli O157:H7 str. EDL933 alpha-amylase NP_288388.1 2703889 D 155864 CDS NP_288389.1 15802363 961927 complement(2705410..2705823) 1 NC_002655.2 hypothetical protein 2705823 yedD 961927 yedD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288389.1 2705410 R 155864 CDS NP_288390.1 15802364 961928 2706010..2707215 1 NC_002655.2 hypothetical protein 2707215 yedE 961928 yedE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288390.1 2706010 D 155864 CDS NP_288391.1 15802365 961929 2707212..2707445 1 NC_002655.2 hypothetical protein 2707445 yedF 961929 yedF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288391.1 2707212 D 155864 CDS NP_288392.1 15802366 961930 2707554..2708222 1 NC_002655.2 hypothetical protein 2708222 yedK 961930 yedK Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288392.1 2707554 D 155864 CDS NP_288393.1 15802367 961931 2708333..2708812 1 NC_002655.2 hypothetical protein 2708812 yedL 961931 yedL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288393.1 2708333 D 155864 CDS NP_288394.1 15802368 961932 complement(2708950..2710089) 1 NC_002655.2 hypothetical protein 2710089 961932 Z3023 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288394.1 2708950 R 155864 CDS NP_288395.1 15802369 961933 2710471..2710770 1 NC_002655.2 hypothetical protein 2710770 961933 Z3025 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288395.1 2710471 D 155864 CDS NP_288396.1 15802370 961934 complement(2710908..2712047) 1 NC_002655.2 hypothetical protein 2712047 961934 Z3026 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288396.1 2710908 R 155864 CDS NP_288397.1 15802371 961935 2712198..2712476 1 NC_002655.2 hypothetical protein 2712476 961935 Z3024 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288397.1 2712198 D 155864 CDS NP_288398.1 15802372 961937 complement(2712396..2712710) 1 NC_002655.2 forms a junction between the M-ring and FlgB during flagella biosynthesis; flagellar hook-basal body protein FliE 2712710 fliE 961937 fliE Escherichia coli O157:H7 str. EDL933 flagellar hook-basal body protein FliE NP_288398.1 2712396 R 155864 CDS NP_288399.1 15802373 961938 2712925..2714583 1 NC_002655.2 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod; flagellar MS-ring protein 2714583 fliF 961938 fliF Escherichia coli O157:H7 str. EDL933 flagellar MS-ring protein NP_288399.1 2712925 D 155864 CDS NP_288400.1 15802374 961939 2714576..2715571 1 NC_002655.2 One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein G 2715571 fliG 961939 fliG Escherichia coli O157:H7 str. EDL933 flagellar motor switch protein G NP_288400.1 2714576 D 155864 CDS NP_288401.2 161367588 961940 2715564..2716250 1 NC_002655.2 binds to and inhibits the function of flagella specific ATPase FliI; flagellar assembly protein H 2716250 fliH 961940 fliH Escherichia coli O157:H7 str. EDL933 flagellar assembly protein H NP_288401.2 2715564 D 155864 CDS NP_288402.2 161367587 961941 2716312..2717685 1 NC_002655.2 involved in type III protein export during flagellum assembly; flagellum-specific ATP synthase 2717685 fliI 961941 fliI Escherichia coli O157:H7 str. EDL933 flagellum-specific ATP synthase NP_288402.2 2716312 D 155864 CDS NP_288403.1 15802377 961942 2717704..2718147 1 NC_002655.2 rod/hook and filament chaperone; flagellar biosynthesis chaperone 2718147 fliJ 961942 fliJ Escherichia coli O157:H7 str. EDL933 flagellar biosynthesis chaperone NP_288403.1 2717704 D 155864 CDS NP_288404.1 15802378 961943 2718144..2719271 1 NC_002655.2 flagellar hook-length control protein 2719271 fliK 961943 fliK Escherichia coli O157:H7 str. EDL933 flagellar hook-length control protein NP_288404.1 2718144 D 155864 CDS NP_288405.1 15802379 961944 2719377..2719841 1 NC_002655.2 interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring; flagellar basal body protein FliL 2719841 fliL 961944 fliL Escherichia coli O157:H7 str. EDL933 flagellar basal body protein FliL NP_288405.1 2719377 D 155864 CDS NP_288406.1 15802380 961945 2719846..2720850 1 NC_002655.2 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation; flagellar motor switch protein FliM 2720850 fliM 961945 fliM Escherichia coli O157:H7 str. EDL933 flagellar motor switch protein FliM NP_288406.1 2719846 D 155864 CDS NP_288407.1 15802381 961946 2720847..2721260 1 NC_002655.2 One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein FliN 2721260 fliN 961946 fliN Escherichia coli O157:H7 str. EDL933 flagellar motor switch protein FliN NP_288407.1 2720847 D 155864 CDS NP_288408.2 161367586 961947 2721263..2721628 1 NC_002655.2 with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus; flagellar biosynthesis protein FliO 2721628 fliO 961947 fliO Escherichia coli O157:H7 str. EDL933 flagellar biosynthesis protein FliO NP_288408.2 2721263 D 155864 CDS NP_288409.1 15802383 961948 2721628..2722365 1 NC_002655.2 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliP 2722365 fliP 961948 fliP Escherichia coli O157:H7 str. EDL933 flagellar biosynthesis protein FliP NP_288409.1 2721628 D 155864 CDS NP_288410.1 15802384 961949 2722375..2722644 1 NC_002655.2 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliQ 2722644 fliQ 961949 fliQ Escherichia coli O157:H7 str. EDL933 flagellar biosynthesis protein FliQ NP_288410.1 2722375 D 155864 CDS NP_288411.1 15802385 961950 2722652..2723437 1 NC_002655.2 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliR 2723437 fliR 961950 fliR Escherichia coli O157:H7 str. EDL933 flagellar biosynthesis protein FliR NP_288411.1 2722652 D 155864 CDS NP_288412.1 15802386 961951 2723727..2724350 1 NC_002655.2 positive regulator for ctr capsule biosynthesis, positive transcription factor 2724350 rcsA 961951 rcsA Escherichia coli O157:H7 str. EDL933 positive regulator for ctr capsule biosynthesis, positive transcription factor NP_288412.1 2723727 D 155864 CDS NP_288413.1 15802387 961952 complement(2724394..2724582) 1 NC_002655.2 hypothetical protein 2724582 dsrB 961952 dsrB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288413.1 2724394 R 155864 CDS NP_288414.1 15802388 961953 2724730..2724972 1 NC_002655.2 hypothetical protein 2724972 961953 Z3043 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288414.1 2724730 D 155864 CDS NP_288415.1 15802389 961955 2725270..2726085 1 NC_002655.2 catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate; mannosyl-3-phosphoglycerate phosphatase 2726085 961955 Z3045 Escherichia coli O157:H7 str. EDL933 mannosyl-3-phosphoglycerate phosphatase NP_288415.1 2725270 D 155864 CDS NP_288416.1 15802390 961956 complement(2726082..2727776) 1 NC_002655.2 hypothetical protein 2727776 961956 Z3047 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288416.1 2726082 R 155864 CDS NP_288417.1 15802391 961957 complement(2727948..2728130) 1 NC_002655.2 hypothetical protein 2728130 961957 Z3048 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288417.1 2727948 R 155864 CDS NP_288418.1 15802392 961958 complement(2728209..2729126) 1 NC_002655.2 hypothetical protein 2729126 yedI 961958 yedI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288418.1 2728209 R 155864 CDS NP_288419.1 15802393 961959 2729299..2730219 1 NC_002655.2 hypothetical protein 2730219 yedA 961959 yedA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288419.1 2729299 D 155864 CDS NP_288420.1 15802394 961960 complement(2730208..2730678) 1 NC_002655.2 DNA mismatch endonuclease, patch repair protein 2730678 vsr 961960 vsr Escherichia coli O157:H7 str. EDL933 DNA mismatch endonuclease, patch repair protein NP_288420.1 2730208 R 155864 CDS NP_288421.1 15802395 961961 complement(2730659..2732077) 1 NC_002655.2 DNA cytosine methylase 2732077 dcm 961961 dcm Escherichia coli O157:H7 str. EDL933 DNA cytosine methylase NP_288421.1 2730659 R 155864 CDS NP_288422.1 15802396 961962 complement(2732144..2732839) 1 NC_002655.2 hypothetical protein 2732839 yedJ 961962 yedJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288422.1 2732144 R 155864 CDS NP_288423.1 15802397 961966 complement(2732935..2733243) 1 NC_002655.2 hypothetical protein 2733243 961966 Z3056 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288423.1 2732935 R 155864 CDS NP_288424.1 15802398 961967 2733780..2734454 1 NC_002655.2 hypothetical protein 2734454 961967 Z3057 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288424.1 2733780 D 155864 CDS NP_288425.1 15802399 961968 2734421..2734996 1 NC_002655.2 hypothetical protein 2734996 961968 Z3058 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288425.1 2734421 D 155864 CDS NP_288426.1 15802400 961970 2735588..2736439 1 NC_002655.2 Hsp31 stabilizes early unfolding protein intermediates under severe heat stress; chaperone protein HchA 2736439 yedU 961970 yedU Escherichia coli O157:H7 str. EDL933 chaperone protein HchA NP_288426.1 2735588 D 155864 CDS NP_288427.1 15802401 961972 complement(2736547..2737905) 1 NC_002655.2 2-component sensor protein 2737905 yedV 961972 yedV Escherichia coli O157:H7 str. EDL933 2-component sensor protein NP_288427.1 2736547 R 155864 CDS NP_288428.2 161367585 961973 complement(2737905..2738576) 1 NC_002655.2 induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced; transcriptional regulatory protein YedW 2738576 yedW 961973 yedW Escherichia coli O157:H7 str. EDL933 transcriptional regulatory protein YedW NP_288428.2 2737905 R 155864 CDS NP_288429.1 15802403 961974 2738710..2739123 1 NC_002655.2 hypothetical protein 2739123 961974 Z3062 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288429.1 2738710 D 155864 CDS NP_288430.1 15802404 961975 2739231..2740235 1 NC_002655.2 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ; sulfite oxidase subunit YedY 2740235 961975 Z3063 Escherichia coli O157:H7 str. EDL933 sulfite oxidase subunit YedY NP_288430.1 2739231 D 155864 CDS NP_288431.1 15802405 961976 2740236..2740871 1 NC_002655.2 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme; sulfite oxidase subunit YedZ 2740871 961976 Z3064 Escherichia coli O157:H7 str. EDL933 sulfite oxidase subunit YedZ NP_288431.1 2740236 D 155864 CDS NP_288432.1 15802406 961977 2741128..2741778 1 NC_002655.2 hypothetical protein 2741778 961977 Z3065 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288432.1 2741128 D 155864 CDS NP_288433.1 15802407 961978 2741888..2742037 1 NC_002655.2 No significant matches; hypothetical protein 2742037 961978 Z3066 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288433.1 2741888 D 155864 CDS NP_288434.1 15802408 961979 2742091..2742651 1 NC_002655.2 cytochrome 2742651 yodB 961979 yodB Escherichia coli O157:H7 str. EDL933 cytochrome NP_288434.1 2742091 D 155864 CDS NP_288435.1 15802409 961980 2743223..2743582 1 NC_002655.2 No significant matches; hypothetical protein 2743582 961980 Z3069 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288435.1 2743223 D 155864 CDS NP_288436.1 15802410 961981 2743790..2744443 1 NC_002655.2 No significant matches; hypothetical protein 2744443 961981 Z3071 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288436.1 2743790 D 155864 CDS NP_288437.1 15802411 961982 2744768..2745922 1 NC_002655.2 hypothetical protein 2745922 961982 Z3072 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288437.1 2744768 D 155864 CDS NP_288438.1 15802412 961983 complement(2746048..2746317) 1 NC_002655.2 hypothetical protein 2746317 961983 Z3073 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288438.1 2746048 R 155864 CDS NP_288439.1 15802413 961984 complement(2746319..2747638) 1 NC_002655.2 tail fiber protein of prophage CP-933U 2747638 961984 Z3074 Escherichia coli O157:H7 str. EDL933 tail fiber protein of prophage CP-933U NP_288439.1 2746319 R 155864 CDS NP_288440.1 15802414 961985 complement(2747697..2748296) 1 NC_002655.2 prophage protein 2748296 lomU 961985 lomU Escherichia coli O157:H7 str. EDL933 prophage protein NP_288440.1 2747697 R 155864 CDS NP_288441.1 15802415 961986 complement(2748365..2751844) 1 NC_002655.2 tail fiber component J of prophage CP-933U 2751844 961986 Z3077 Escherichia coli O157:H7 str. EDL933 tail fiber component J of prophage CP-933U NP_288441.1 2748365 R 155864 CDS NP_288442.1 15802416 961987 complement(2752085..2752621) 1 NC_002655.2 tail fiber component I of prophage CP-933U 2752621 961987 Z3079 Escherichia coli O157:H7 str. EDL933 tail fiber component I of prophage CP-933U NP_288442.1 2752085 R 155864 CDS NP_288443.1 15802417 961988 complement(2752660..2753541) 1 NC_002655.2 tail fiber component K of prophage CP-933U 2753541 961988 Z3081 Escherichia coli O157:H7 str. EDL933 tail fiber component K of prophage CP-933U NP_288443.1 2752660 R 155864 CDS NP_288444.1 15802418 961989 complement(2753414..2754112) 1 NC_002655.2 tail fiber component L of prophage CP-933U 2754112 961989 Z3082 Escherichia coli O157:H7 str. EDL933 tail fiber component L of prophage CP-933U NP_288444.1 2753414 R 155864 CDS NP_288445.1 15802419 961990 complement(2754112..2754441) 1 NC_002655.2 tail fiber component M of prophage CP-933U 2754441 961990 Z3083 Escherichia coli O157:H7 str. EDL933 tail fiber component M of prophage CP-933U NP_288445.1 2754112 R 155864 CDS NP_288446.1 15802420 961991 complement(2754438..2757092) 1 NC_002655.2 tail fiber component H of prophage CP-933U 2757092 961991 Z3084 Escherichia coli O157:H7 str. EDL933 tail fiber component H of prophage CP-933U NP_288446.1 2754438 R 155864 CDS NP_288447.1 15802421 961992 complement(2757127..2757435) 1 NC_002655.2 tail fiber component T of prophage CP-933U 2757435 961992 Z3085 Escherichia coli O157:H7 str. EDL933 tail fiber component T of prophage CP-933U NP_288447.1 2757127 R 155864 CDS NP_288448.1 15802422 961993 complement(2757462..2757884) 1 NC_002655.2 tail fiber component G of prophage CP-933U 2757884 961993 Z3086 Escherichia coli O157:H7 str. EDL933 tail fiber component G of prophage CP-933U NP_288448.1 2757462 R 155864 CDS NP_288449.1 15802423 961994 complement(2757898..2758650) 1 NC_002655.2 tail fiber component V of prophage CP-933U 2758650 961994 Z3087 Escherichia coli O157:H7 str. EDL933 tail fiber component V of prophage CP-933U NP_288449.1 2757898 R 155864 CDS NP_288450.1 15802424 961995 complement(2758658..2759056) 1 NC_002655.2 tail fiber component U of prophage CP-933U 2759056 961995 Z3088 Escherichia coli O157:H7 str. EDL933 tail fiber component U of prophage CP-933U NP_288450.1 2758658 R 155864 CDS NP_288451.1 15802425 961996 complement(2759069..2759698) 1 NC_002655.2 tail fiber component Z of prophage CP-933U 2759698 961996 Z3089 Escherichia coli O157:H7 str. EDL933 tail fiber component Z of prophage CP-933U NP_288451.1 2759069 R 155864 CDS NP_288452.1 15802426 961997 complement(2759695..2759976) 1 NC_002655.2 No significant matches; hypothetical protein 2759976 961997 Z3090 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288452.1 2759695 R 155864 CDS NP_288453.1 15802427 961998 complement(2759969..2760295) 1 NC_002655.2 No significant matches; hypothetical protein 2760295 961998 Z3091 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288453.1 2759969 R 155864 CDS NP_288454.1 15802428 961999 complement(2760383..2761423) 1 NC_002655.2 No significant matches; hypothetical protein 2761423 961999 Z3092 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288454.1 2760383 R 155864 CDS NP_288455.1 15802429 962000 2761545..2761871 1 NC_002655.2 hypothetical protein 2761871 962000 Z3093 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288455.1 2761545 D 155864 CDS NP_288456.1 15802430 962001 2761893..2762759 1 NC_002655.2 transposase encoded within prophage CP-933U 2762759 962001 Z3095 Escherichia coli O157:H7 str. EDL933 transposase encoded within prophage CP-933U NP_288456.1 2761893 D 155864 CDS NP_288457.1 15802431 962002 complement(2762762..2763721) 1 NC_002655.2 peptidase encoded within prophage CP-933U 2763721 962002 Z3097 Escherichia coli O157:H7 str. EDL933 peptidase encoded within prophage CP-933U NP_288457.1 2762762 R 155864 CDS NP_288458.1 15802432 962003 complement(2763666..2765168) 1 NC_002655.2 head-tail preconnector protein of prophage CP-933U 2765168 962003 Z3098 Escherichia coli O157:H7 str. EDL933 head-tail preconnector protein of prophage CP-933U NP_288458.1 2763666 R 155864 CDS NP_288459.1 15802433 962004 complement(2765377..2767389) 1 NC_002655.2 DNA packaging protein of prophage CP-933U 2767389 962004 Z3099 Escherichia coli O157:H7 str. EDL933 DNA packaging protein of prophage CP-933U NP_288459.1 2765377 R 155864 CDS NP_288460.1 15802434 962005 complement(2767497..2767973) 1 NC_002655.2 No significant matches; hypothetical protein 2767973 962005 Z3100 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288460.1 2767497 R 155864 CDS NP_288461.1 15802435 962006 complement(2768428..2768895) 1 NC_002655.2 endopeptidase of prophage CP-933U 2768895 962006 Z3101 Escherichia coli O157:H7 str. EDL933 endopeptidase of prophage CP-933U NP_288461.1 2768428 R 155864 CDS NP_288462.1 15802436 962007 complement(2769049..2769618) 1 NC_002655.2 No significant matches; antirepressor protein of prophage CP-933U 2769618 antU 962007 antU Escherichia coli O157:H7 str. EDL933 antirepressor protein of prophage CP-933U NP_288462.1 2769049 R 155864 CDS NP_288463.1 15802437 962008 complement(2769889..2770422) 1 NC_002655.2 endolysin of prophage CP-933U 2770422 962008 Z3104 Escherichia coli O157:H7 str. EDL933 endolysin of prophage CP-933U NP_288463.1 2769889 R 155864 CDS NP_288464.1 15802438 962009 complement(2770473..2770820) 1 NC_002655.2 hypothetical protein 2770820 962009 Z3105 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288464.1 2770473 R 155864 CDS NP_288465.1 15802439 962010 complement(2770822..2771136) 1 NC_002655.2 holin protein of prophage CP-933U 2771136 962010 Z3106 Escherichia coli O157:H7 str. EDL933 holin protein of prophage CP-933U NP_288465.1 2770822 R 155864 CDS NP_288466.1 15802440 962011 complement(2771187..2773040) 1 NC_002655.2 hypothetical protein 2773040 962011 Z3107 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288466.1 2771187 R 155864 CDS NP_288467.1 15802441 962012 complement(2773354..2773521) 1 NC_002655.2 No significant matches; hypothetical protein 2773521 962012 Z3108 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288467.1 2773354 R 155864 CDS NP_288468.1 15802442 962013 complement(2773518..2773937) 1 NC_002655.2 hypothetical protein 2773937 962013 Z3109 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288468.1 2773518 R 155864 CDS NP_288469.1 15802443 962017 complement(2774580..2775269) 1 NC_002655.2 antitermination protein Q 2775269 962017 Z3114 Escherichia coli O157:H7 str. EDL933 antitermination protein Q NP_288469.1 2774580 R 155864 CDS NP_288470.1 15802444 962018 complement(2775266..2775625) 1 NC_002655.2 endonuclease encoded within prophage CP-933U 2775625 962018 Z3115 Escherichia coli O157:H7 str. EDL933 endonuclease encoded within prophage CP-933U NP_288470.1 2775266 R 155864 CDS NP_288471.1 15802445 962019 complement(2775638..2776687) 1 NC_002655.2 hypothetical protein 2776687 962019 Z3116 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288471.1 2775638 R 155864 CDS NP_288472.1 15802446 962020 2776770..2777093 1 NC_002655.2 No significant matches; hypothetical protein 2777093 962020 Z3117 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288472.1 2776770 D 155864 CDS NP_288473.1 15802447 962021 complement(2777534..2777638) 1 NC_002655.2 No significant matches; hypothetical protein 2777638 962021 Z3118 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288473.1 2777534 R 155864 CDS NP_288474.1 15802448 962022 complement(2777748..2778311) 1 NC_002655.2 hypothetical protein 2778311 962022 Z3119 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288474.1 2777748 R 155864 CDS NP_288475.1 15802449 962023 complement(2778438..2778749) 1 NC_002655.2 No significant matches; hypothetical protein 2778749 962023 Z3120 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288475.1 2778438 R 155864 CDS NP_288476.1 15802450 962024 complement(2778931..2779287) 1 NC_002655.2 No significant matches; hypothetical protein 2779287 962024 Z3121 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288476.1 2778931 R 155864 CDS NP_288477.1 15802451 962025 complement(2779530..2780294) 1 NC_002655.2 hypothetical protein 2780294 962025 Z3122 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288477.1 2779530 R 155864 CDS NP_288478.1 15802452 962026 complement(2780263..2780925) 1 NC_002655.2 hypothetical protein 2780925 962026 Z3123 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288478.1 2780263 R 155864 CDS NP_288479.1 15802453 962027 complement(2780717..2781754) 1 NC_002655.2 hypothetical protein 2781754 962027 Z3124 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288479.1 2780717 R 155864 CDS NP_288480.1 15802454 962028 complement(2781823..2782248) 1 NC_002655.2 hypothetical protein 2782248 962028 Z3125 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288480.1 2781823 R 155864 CDS NP_288481.1 15802455 962029 2782567..2783157 1 NC_002655.2 repressor protein of prophage CP-933U 2783157 962029 Z3126 Escherichia coli O157:H7 str. EDL933 repressor protein of prophage CP-933U NP_288481.1 2782567 D 155864 CDS NP_288482.1 15802456 962030 2783489..2783641 1 NC_002655.2 hypothetical protein 2783641 962030 Z3127 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288482.1 2783489 D 155864 CDS NP_288483.1 15802457 962031 2784122..2784310 1 NC_002655.2 inhibitor of cell division encoded within prophage CP-933U 2784310 962031 Z3128 Escherichia coli O157:H7 str. EDL933 inhibitor of cell division encoded within prophage CP-933U NP_288483.1 2784122 D 155864 CDS NP_288484.1 15802458 962032 2784593..2787064 1 NC_002655.2 exodeoxyribonuclease VIII 2787064 exoU 962032 exoU Escherichia coli O157:H7 str. EDL933 exodeoxyribonuclease VIII NP_288484.1 2784593 D 155864 CDS NP_288485.1 15802459 962033 2787326..2788348 1 NC_002655.2 integrase for prophage CP-933U 2788348 intU 962033 intU Escherichia coli O157:H7 str. EDL933 integrase for prophage CP-933U NP_288485.1 2787326 D 155864 CDS NP_288486.1 15802460 962035 2788545..2789381 1 NC_002655.2 hypothetical protein 2789381 962035 Z3132 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288486.1 2788545 D 155864 CDS NP_288487.1 15802461 962037 2789871..2797853 1 NC_002655.2 invasin 2797853 962037 Z3135 Escherichia coli O157:H7 str. EDL933 invasin NP_288487.1 2789871 D 155864 CDS NP_288488.1 15802462 962038 complement(2790411..2790656) 1 NC_002655.2 No significant matches; hypothetical protein 2790656 962038 Z3136 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288488.1 2790411 R 155864 CDS NP_288489.1 15802463 962039 complement(2798115..2799167) 1 NC_002655.2 hypothetical protein 2799167 962039 Z3137 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288489.1 2798115 R 155864 CDS NP_288490.1 15802464 962040 2799481..2800797 1 NC_002655.2 shikimate transporter 2800797 shiA 962040 shiA Escherichia coli O157:H7 str. EDL933 shikimate transporter NP_288490.1 2799481 D 155864 CDS NP_288491.1 15802465 962041 2800899..2802353 1 NC_002655.2 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile; AMP nucleosidase 2802353 amn 962041 amn Escherichia coli O157:H7 str. EDL933 AMP nucleosidase NP_288491.1 2800899 D 155864 CDS NP_288492.1 15802466 962042 2802696..2803412 1 NC_002655.2 hypothetical protein 2803412 962042 Z3140 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288492.1 2802696 D 155864 CDS NP_288493.1 15802467 962044 complement(2804038..2804361) 1 NC_002655.2 hypothetical protein 2804361 962044 Z3143 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288493.1 2804038 R 155864 CDS NP_288494.2 161367584 962045 complement(2804386..2805678) 1 NC_002655.2 hypothetical protein 2805678 962045 Z3144 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288494.2 2804386 R 155864 CDS NP_288495.1 15802469 962047 complement(2805799..2806749) 1 NC_002655.2 LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB; transcriptional regulator Cbl 2806749 cbl 962047 cbl Escherichia coli O157:H7 str. EDL933 transcriptional regulator Cbl NP_288495.1 2805799 R 155864 CDS NP_288496.1 15802470 962048 complement(2806851..2807768) 1 NC_002655.2 Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation; nitrogen assimilation transcriptional regulator 2807768 nac 962048 nac Escherichia coli O157:H7 str. EDL933 nitrogen assimilation transcriptional regulator NP_288496.1 2806851 R 155864 CDS NP_288497.1 15802471 962050 complement(2808225..2809157) 1 NC_002655.2 hypothetical protein 2809157 erfK 962050 erfK Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288497.1 2808225 R 155864 CDS NP_288498.1 15802472 962051 complement(2809222..2810301) 1 NC_002655.2 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 2810301 cobT 962051 cobT Escherichia coli O157:H7 str. EDL933 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase NP_288498.1 2809222 R 155864 CDS NP_288499.1 15802473 962052 complement(2810313..2811056) 1 NC_002655.2 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase 2811056 cobS 962052 cobS Escherichia coli O157:H7 str. EDL933 cobalamin synthase NP_288499.1 2810313 R 155864 CDS NP_288500.1 15802474 962053 complement(2811053..2811598) 1 NC_002655.2 catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP; adenosylcobinamide kinase 2811598 cobU 962053 cobU Escherichia coli O157:H7 str. EDL933 adenosylcobinamide kinase NP_288500.1 2811053 R 155864 CDS NP_288501.1 15802475 962054 2811939..2812340 1 NC_002655.2 hypothetical protein 2812340 962054 Z3154 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288501.1 2811939 D 155864 CDS NP_288502.1 15802476 962055 2812337..2812684 1 NC_002655.2 hypothetical protein 2812684 962055 Z3155 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288502.1 2812337 D 155864 CDS NP_288503.1 15802477 962056 2812734..2814272 1 NC_002655.2 hypothetical protein 2814272 962056 Z3156 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288503.1 2812734 D 155864 CDS NP_288504.1 15802478 962057 2815709..2817868 1 NC_002655.2 outer membrane receptor for iron compound or colicin 2817868 962057 Z3159 Escherichia coli O157:H7 str. EDL933 outer membrane receptor for iron compound or colicin NP_288504.1 2815709 D 155864 CDS NP_288505.1 15802479 962058 2818240..2818566 1 NC_002655.2 hypothetical protein 2818566 962058 Z3161 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288505.1 2818240 D 155864 CDS NP_288506.1 15802480 962059 2818563..2819453 1 NC_002655.2 IS629 transposase 2819453 962059 Z3162 Escherichia coli O157:H7 str. EDL933 IS629 transposase NP_288506.1 2818563 D 155864 CDS NP_288507.1 15802481 962060 2819535..2819756 1 NC_002655.2 hypothetical protein 2819756 yeeT 962060 yeeT Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288507.1 2819535 D 155864 CDS NP_288508.1 15802482 962061 2819830..2820198 1 NC_002655.2 structural protein 2820198 yeeU 962061 yeeU Escherichia coli O157:H7 str. EDL933 structural protein NP_288508.1 2819830 D 155864 CDS NP_288509.1 15802483 962062 2820287..2820550 1 NC_002655.2 hypothetical protein 2820550 962062 Z3165 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288509.1 2820287 D 155864 CDS NP_288510.1 15802484 962063 2820657..2820851 1 NC_002655.2 hypothetical protein 2820851 yeeW 962063 yeeW Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288510.1 2820657 D 155864 CDS NP_288511.1 15802485 962064 2821293..2821649 1 NC_002655.2 No significant matches; hypothetical protein 2821649 962064 Z3167 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288511.1 2821293 D 155864 CDS NP_288512.1 15802486 962065 complement(2821750..2822145) 1 NC_002655.2 hypothetical protein 2822145 yeeX 962065 yeeX Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288512.1 2821750 R 155864 CDS NP_288513.1 15802487 962066 complement(2822251..2823309) 1 NC_002655.2 hypothetical protein 2823309 yeeA 962066 yeeA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288513.1 2822251 R 155864 CDS NP_288514.1 15802488 962067 complement(2823508..2823981) 1 NC_002655.2 DNA gyrase inhibitor 2823981 sbmC 962067 sbmC Escherichia coli O157:H7 str. EDL933 DNA gyrase inhibitor NP_288514.1 2823508 R 155864 CDS NP_288515.1 15802489 962068 complement(2824100..2825272) 1 NC_002655.2 removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 2825272 dacD 962068 dacD Escherichia coli O157:H7 str. EDL933 D-alanyl-D-alanine carboxypeptidase NP_288515.1 2824100 R 155864 CDS NP_288516.2 157267360 962069 2825476..2826903 1 NC_002655.2 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I 2826903 sbcB 962069 sbcB Escherichia coli O157:H7 str. EDL933 exonuclease I NP_288516.2 2825476 D 155864 CDS NP_288517.1 15802491 962070 complement(2826946..2827173) 1 NC_002655.2 hypothetical protein 2827173 yeeD 962070 yeeD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288517.1 2826946 R 155864 CDS NP_288518.1 15802492 962071 complement(2827187..2828245) 1 NC_002655.2 transport system permease 2828245 yeeE 962071 yeeE Escherichia coli O157:H7 str. EDL933 transport system permease NP_288518.1 2827187 R 155864 CDS NP_288519.1 15802493 962072 complement(2828424..2829788) 1 NC_002655.2 amino acid/amine transport protein 2829788 yeeF 962072 yeeF Escherichia coli O157:H7 str. EDL933 amino acid/amine transport protein NP_288519.1 2828424 R 155864 CDS NP_288520.1 15802494 962073 complement(2830049..2830999) 1 NC_002655.2 LysR family transcriptional regulator 2830999 yeeY 962073 yeeY Escherichia coli O157:H7 str. EDL933 LysR family transcriptional regulator NP_288520.1 2830049 R 155864 CDS NP_288521.1 15802495 962074 complement(2831024..2831848) 1 NC_002655.2 enzyme of sugar metabolism 2831848 962074 Z3178 Escherichia coli O157:H7 str. EDL933 enzyme of sugar metabolism NP_288521.1 2831024 R 155864 CDS NP_288522.1 15802496 962075 2831921..2832127 1 NC_002655.2 No significant matches; hypothetical protein 2832127 962075 Z3179 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288522.1 2831921 D 155864 CDS NP_288524.1 15802498 962077 2832470..2833369 1 NC_002655.2 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 2833369 hisG 962077 hisG Escherichia coli O157:H7 str. EDL933 ATP phosphoribosyltransferase NP_288524.1 2832470 D 155864 CDS NP_288525.1 15802499 962078 2833375..2834679 1 NC_002655.2 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 2834679 hisD 962078 hisD Escherichia coli O157:H7 str. EDL933 histidinol dehydrogenase NP_288525.1 2833375 D 155864 CDS NP_288526.1 15802500 962079 2834676..2835746 1 NC_002655.2 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 2835746 hisC 962079 hisC Escherichia coli O157:H7 str. EDL933 histidinol-phosphate aminotransferase NP_288526.1 2834676 D 155864 CDS NP_288527.2 161367583 962080 2835746..2836813 1 NC_002655.2 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 2836813 hisB 962080 hisB Escherichia coli O157:H7 str. EDL933 imidazole glycerol-phosphate dehydratase/histidinol phosphatase NP_288527.2 2835746 D 155864 CDS NP_288528.1 15802502 962081 2836813..2837403 1 NC_002655.2 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 2837403 hisH 962081 hisH Escherichia coli O157:H7 str. EDL933 imidazole glycerol phosphate synthase subunit HisH NP_288528.1 2836813 D 155864 CDS NP_288529.2 161367582 962082 2837403..2838140 1 NC_002655.2 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2838140 hisA 962082 hisA Escherichia coli O157:H7 str. EDL933 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase NP_288529.2 2837403 D 155864 CDS NP_288530.1 15802504 962083 2838122..2838898 1 NC_002655.2 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 2838898 hisF 962083 hisF Escherichia coli O157:H7 str. EDL933 imidazole glycerol phosphate synthase subunit HisF NP_288530.1 2838122 D 155864 CDS NP_288531.1 15802505 962084 2838892..2839503 1 NC_002655.2 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase 2839503 hisI 962084 hisI Escherichia coli O157:H7 str. EDL933 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase NP_288531.1 2838892 D 155864 CDS NP_288532.1 15802506 962085 complement(2839600..2840613) 1 NC_002655.2 regulator of length of O-antigen component of lipopolysaccharide chains 2840613 wzzB 962085 wzzB Escherichia coli O157:H7 str. EDL933 regulator of length of O-antigen component of lipopolysaccharide chains NP_288532.1 2839600 R 155864 CDS NP_288533.1 15802507 962086 complement(2840723..2841889) 1 NC_002655.2 UDP-glucose 6-dehydrogenase 2841889 ugd 962086 ugd Escherichia coli O157:H7 str. EDL933 UDP-glucose 6-dehydrogenase NP_288533.1 2840723 R 155864 CDS NP_288534.1 15802508 962087 complement(2842138..2843544) 1 NC_002655.2 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 2843544 gnd 962087 gnd Escherichia coli O157:H7 str. EDL933 6-phosphogluconate dehydrogenase NP_288534.1 2842138 R 155864 CDS NP_288535.1 15802509 962088 complement(2843745..2844410) 1 NC_002655.2 acetyl transferase; O-antigen biosynthesis 2844410 wbdR 962088 wbdR Escherichia coli O157:H7 str. EDL933 acetyl transferase; O-antigen biosynthesis NP_288535.1 2843745 R 155864 CDS NP_288536.1 15802510 962089 complement(2845674..2847044) 1 NC_002655.2 phosphomannomutase 2847044 manB 962089 manB Escherichia coli O157:H7 str. EDL933 phosphomannomutase NP_288536.1 2845674 R 155864 CDS NP_288537.1 15802511 962090 complement(2847048..2848496) 1 NC_002655.2 mannose-1-phosphate guanylyltransferase 2848496 manC 962090 manC Escherichia coli O157:H7 str. EDL933 mannose-1-phosphate guanylyltransferase NP_288537.1 2847048 R 155864 CDS NP_288538.1 15802512 962091 complement(2848478..2848987) 1 NC_002655.2 GDP-mannose mannosyl hydrolase 2848987 wbdQ 962091 wbdQ Escherichia coli O157:H7 str. EDL933 GDP-mannose mannosyl hydrolase NP_288538.1 2848478 R 155864 CDS NP_288539.1 15802513 962092 complement(2848990..2849955) 1 NC_002655.2 fucose synthetase 2849955 fcI 962092 fcI Escherichia coli O157:H7 str. EDL933 fucose synthetase NP_288539.1 2848990 R 155864 CDS NP_288540.1 15802514 962093 complement(2849958..2851076) 1 NC_002655.2 GDP-mannose dehydratase 2851076 962093 Z3198 Escherichia coli O157:H7 str. EDL933 GDP-mannose dehydratase NP_288540.1 2849958 R 155864 CDS NP_288541.1 15802515 962094 complement(2851096..2852310) 1 NC_002655.2 glycosyl transferase 2852310 wbdP 962094 wbdP Escherichia coli O157:H7 str. EDL933 glycosyl transferase NP_288541.1 2851096 R 155864 CDS NP_288542.1 15802516 962095 complement(2852335..2853429) 1 NC_002655.2 perosamine synthetase 2853429 per 962095 per Escherichia coli O157:H7 str. EDL933 perosamine synthetase NP_288542.1 2852335 R 155864 CDS NP_288543.1 15802517 962096 complement(2853432..2854823) 1 NC_002655.2 O antigen flippase Wzx 2854823 wzx 962096 wzx Escherichia coli O157:H7 str. EDL933 O antigen flippase Wzx NP_288543.1 2853432 R 155864 CDS NP_288544.1 15802518 962097 complement(2854810..2855556) 1 NC_002655.2 glycosyl transferase 2855556 wbdO 962097 wbdO Escherichia coli O157:H7 str. EDL933 glycosyl transferase NP_288544.1 2854810 R 155864 CDS NP_288545.1 15802519 962098 complement(2855525..2856709) 1 NC_002655.2 O antigen polymerase 2856709 wzy 962098 wzy Escherichia coli O157:H7 str. EDL933 O antigen polymerase NP_288545.1 2855525 R 155864 CDS NP_288546.1 15802520 962099 complement(2856706..2857488) 1 NC_002655.2 glycosyl transferase 2857488 wbdN 962099 wbdN Escherichia coli O157:H7 str. EDL933 glycosyl transferase NP_288546.1 2856706 R 155864 CDS NP_288547.1 15802521 962100 complement(2857807..2858700) 1 NC_002655.2 together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP-glucose-1-phosphate uridylyltransferase 2858700 galF 962100 galF Escherichia coli O157:H7 str. EDL933 UTP-glucose-1-phosphate uridylyltransferase NP_288547.1 2857807 R 155864 CDS NP_288548.1 15802522 962101 complement(2858943..2859938) 1 NC_002655.2 UDP-galactose 4-epimerase 2859938 962101 Z3206 Escherichia coli O157:H7 str. EDL933 UDP-galactose 4-epimerase NP_288548.1 2858943 R 155864 CDS NP_288549.1 15802523 962102 complement(2860096..2861490) 1 NC_002655.2 WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid; colanic acid biosynthesis protein 2861490 wcaM 962102 wcaM Escherichia coli O157:H7 str. EDL933 colanic acid biosynthesis protein NP_288549.1 2860096 R 155864 CDS NP_288550.1 15802524 962103 complement(2861501..2862721) 1 NC_002655.2 colanic acid biosynthesis glycosyl transferase 2862721 wcaL 962103 wcaL Escherichia coli O157:H7 str. EDL933 colanic acid biosynthesis glycosyl transferase NP_288550.1 2861501 R 155864 CDS NP_288551.1 15802525 962104 complement(2862718..2863998) 1 NC_002655.2 pyruvyl transferase 2863998 wcaK 962104 wcaK Escherichia coli O157:H7 str. EDL933 pyruvyl transferase NP_288551.1 2862718 R 155864 CDS NP_288552.1 15802526 962105 complement(2864178..2865656) 1 NC_002655.2 colanic acid exporter 2865656 wzxC 962105 wzxC Escherichia coli O157:H7 str. EDL933 colanic acid exporter NP_288552.1 2864178 R 155864 CDS NP_288553.1 15802527 962106 complement(2865658..2867052) 1 NC_002655.2 WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid; UDP-glucose lipid carrier transferase 2867052 wcaJ 962106 wcaJ Escherichia coli O157:H7 str. EDL933 UDP-glucose lipid carrier transferase NP_288553.1 2865658 R 155864 CDS NP_288554.1 15802528 962107 complement(2867107..2868477) 1 NC_002655.2 phosphomannomutase 2868477 cpsG 962107 cpsG Escherichia coli O157:H7 str. EDL933 phosphomannomutase NP_288554.1 2867107 R 155864 CDS NP_288555.1 15802529 962108 complement(2868670..2870106) 1 NC_002655.2 mannose-1-phosphate guanylyltransferase 2870106 cpsB 962108 cpsB Escherichia coli O157:H7 str. EDL933 mannose-1-phosphate guanylyltransferase NP_288555.1 2868670 R 155864 CDS NP_288556.1 15802530 962109 complement(2870109..2871332) 1 NC_002655.2 glycosyl transferase 2871332 wcaI 962109 wcaI Escherichia coli O157:H7 str. EDL933 glycosyl transferase NP_288556.1 2870109 R 155864 CDS NP_288557.1 15802531 956665 complement(2871329..2871811) 1 NC_002655.2 GDP-mannose mannosyl hydrolase 2871811 wcaH 956665 wcaH Escherichia coli O157:H7 str. EDL933 GDP-mannose mannosyl hydrolase NP_288557.1 2871329 R 155864 CDS NP_288558.1 15802532 957230 complement(2871811..2872776) 1 NC_002655.2 nucleotide di-P-sugar epimerase or dehydratase 2872776 wcaG 957230 wcaG Escherichia coli O157:H7 str. EDL933 nucleotide di-P-sugar epimerase or dehydratase NP_288558.1 2871811 R 155864 CDS NP_288559.1 15802533 957035 complement(2872779..2873900) 1 NC_002655.2 GDP-D-mannose dehydratase 2873900 gmd 957035 gmd Escherichia coli O157:H7 str. EDL933 GDP-D-mannose dehydratase NP_288559.1 2872779 R 155864 CDS NP_288560.1 15802534 956732 complement(2873929..2874477) 1 NC_002655.2 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); colanic acid biosynthesis acetyltransferase WcaF 2874477 wcaF 956732 wcaF Escherichia coli O157:H7 str. EDL933 colanic acid biosynthesis acetyltransferase WcaF NP_288560.1 2873929 R 155864 CDS NP_288561.1 15802535 956927 complement(2874493..2875239) 1 NC_002655.2 glycosyl transferase 2875239 wcaE 956927 wcaE Escherichia coli O157:H7 str. EDL933 glycosyl transferase NP_288561.1 2874493 R 155864 CDS NP_288562.1 15802536 959508 complement(2875250..2876467) 1 NC_002655.2 essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance; colanic acid biosynthesis protein 2876467 wcaD 959508 wcaD Escherichia coli O157:H7 str. EDL933 colanic acid biosynthesis protein NP_288562.1 2875250 R 155864 CDS NP_288563.1 15802537 958422 complement(2876442..2877659) 1 NC_002655.2 glycosyl transferase 2877659 wcaC 958422 wcaC Escherichia coli O157:H7 str. EDL933 glycosyl transferase NP_288563.1 2876442 R 155864 CDS NP_288564.1 15802538 958129 complement(2877656..2878144) 1 NC_002655.2 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium; colanic acid biosynthesis acetyltransferase WcaB 2878144 wcaB 958129 wcaB Escherichia coli O157:H7 str. EDL933 colanic acid biosynthesis acetyltransferase WcaB NP_288564.1 2877656 R 155864 CDS NP_288565.1 15802539 956990 complement(2878147..2878986) 1 NC_002655.2 glycosyl transferase 2878986 wcaA 956990 wcaA Escherichia coli O157:H7 str. EDL933 glycosyl transferase NP_288565.1 2878147 R 155864 CDS NP_288566.2 161367581 956738 complement(2879079..2881241) 1 NC_002655.2 Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide); tyrosine kinase 2881241 956738 Z3224 Escherichia coli O157:H7 str. EDL933 tyrosine kinase NP_288566.2 2879079 R 155864 CDS NP_288567.1 15802541 956740 complement(2881244..2881687) 1 NC_002655.2 Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis; tyrosine phosphatase 2881687 wzb 956740 wzb Escherichia coli O157:H7 str. EDL933 tyrosine phosphatase NP_288567.1 2881244 R 155864 CDS NP_288568.1 15802542 956750 complement(2881693..2882832) 1 NC_002655.2 polysaccharide export protein 2882832 wza 956750 wza Escherichia coli O157:H7 str. EDL933 polysaccharide export protein NP_288568.1 2881693 R 155864 CDS NP_288569.1 15802543 958470 2883426..2885075 1 NC_002655.2 transporter 2885075 yegH 958470 yegH Escherichia coli O157:H7 str. EDL933 transporter NP_288569.1 2883426 D 155864 CDS NP_288570.1 15802544 960786 2885150..2885488 1 NC_002655.2 hypothetical protein 2885488 960786 Z3230 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288570.1 2885150 D 155864 CDS NP_288571.1 15802545 958088 2885478..2885768 1 NC_002655.2 hypothetical protein 2885768 958088 Z3231 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288571.1 2885478 D 155864 CDS NP_288572.2 157267361 956763 complement(2885821..2887674) 1 NC_002655.2 YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs; assembly protein 2887674 asmA 956763 asmA Escherichia coli O157:H7 str. EDL933 assembly protein NP_288572.2 2885821 R 155864 CDS NP_288573.1 15802547 959524 complement(2887696..2888277) 1 NC_002655.2 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 2888277 dcd 959524 dcd Escherichia coli O157:H7 str. EDL933 deoxycytidine triphosphate deaminase NP_288573.1 2887696 R 155864 CDS NP_288574.2 161367580 956798 complement(2888369..2889010) 1 NC_002655.2 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 2889010 udk 956798 udk Escherichia coli O157:H7 str. EDL933 uridine kinase NP_288574.2 2888369 R 155864 CDS NP_288575.1 15804978 959644 join(2889330..2889785,2889787..2892648) 1 NC_002655.2 contains a MASE1 (Membrane-Associated Sensor) domain; potentially involved in signal transduction; sensor protein 2892648 959644 Z3235m Escherichia coli O157:H7 str. EDL933 sensor protein NP_288575.1 2889330 D 155864 CDS NP_288576.1 15802549 958151 complement(2892749..2893597) 1 NC_002655.2 inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine; 3-methyladenine DNA glycosylase 2893597 alkA 958151 alkA Escherichia coli O157:H7 str. EDL933 3-methyladenine DNA glycosylase NP_288576.1 2892749 R 155864 CDS NP_288577.2 161367579 961423 2893731..2895083 1 NC_002655.2 chaperone 2895083 yegD 961423 yegD Escherichia coli O157:H7 str. EDL933 chaperone NP_288577.2 2893731 D 155864 CDS NP_288578.1 15802551 956769 complement(2895096..2897036) 1 NC_002655.2 chaperonin 2897036 956769 Z3239 Escherichia coli O157:H7 str. EDL933 chaperonin NP_288578.1 2895096 R 155864 CDS NP_288579.1 15802552 956785 complement(2897033..2897794) 1 NC_002655.2 hypothetical protein 2897794 956785 Z3240 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288579.1 2897033 R 155864 CDS NP_288580.1 15802553 956810 complement(2897791..2898450) 1 NC_002655.2 hypothetical protein 2898450 956810 Z3241 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288580.1 2897791 R 155864 CDS NP_288581.1 15802554 956829 2899022..2899168 1 NC_002655.2 No significant matches; hypothetical protein 2899168 956829 Z3242 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288581.1 2899022 D 155864 CDS NP_288582.2 161367578 956779 2899668..2900915 1 NC_002655.2 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtA 2900915 956779 Z3243 Escherichia coli O157:H7 str. EDL933 multidrug efflux system subunit MdtA NP_288582.2 2899668 D 155864 CDS NP_288583.1 15802556 956780 2900915..2904037 1 NC_002655.2 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtB 2904037 yegN 956780 yegN Escherichia coli O157:H7 str. EDL933 multidrug efflux system subunit MdtB NP_288583.1 2900915 D 155864 CDS NP_288584.1 15802557 956783 2904038..2907115 1 NC_002655.2 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtC 2907115 yegO 956783 yegO Escherichia coli O157:H7 str. EDL933 multidrug efflux system subunit MdtC NP_288584.1 2904038 D 155864 CDS NP_288585.1 15802558 956803 2907116..2908531 1 NC_002655.2 multidrug efflux system protein MdtE 2908531 yegB 956803 yegB Escherichia coli O157:H7 str. EDL933 multidrug efflux system protein MdtE NP_288585.1 2907116 D 155864 CDS NP_288586.1 15802559 958087 2908528..2909931 1 NC_002655.2 signal transduction histidine-protein kinase BaeS 2909931 baeS 958087 baeS Escherichia coli O157:H7 str. EDL933 signal transduction histidine-protein kinase BaeS NP_288586.1 2908528 D 155864 CDS NP_288587.1 15802560 959577 2909928..2910650 1 NC_002655.2 response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport; DNA-binding transcriptional regulator BaeR 2910650 baeR 959577 baeR Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator BaeR NP_288587.1 2909928 D 155864 CDS NP_288588.1 15802561 956806 2910802..2911173 1 NC_002655.2 hypothetical protein 2911173 956806 Z3249 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288588.1 2910802 D 155864 CDS NP_288589.1 15802562 958264 2911321..2912682 1 NC_002655.2 hypothetical protein 2912682 yegQ 958264 yegQ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288589.1 2911321 D 155864 CDS NP_288590.1 15802563 957197 complement(2913012..2913389) 1 NC_002655.2 hypothetical protein 2913389 957197 Z3251 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288590.1 2913012 R 155864 CDS NP_288591.1 15802564 957780 2913735..2914634 1 NC_002655.2 cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role; lipid kinase 2914634 957780 Z3252 Escherichia coli O157:H7 str. EDL933 lipid kinase NP_288591.1 2913735 D 155864 CDS NP_288592.1 15802565 956860 complement(2914716..2915162) 1 NC_002655.2 galactitol utilization operon repressor 2915162 gatR 956860 gatR Escherichia coli O157:H7 str. EDL933 galactitol utilization operon repressor NP_288592.1 2914716 R 155864 CDS NP_288593.1 15802566 956811 complement(2915595..2916635) 1 NC_002655.2 Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate; galactitol-1-phosphate dehydrogenase 2916635 gatD 956811 gatD Escherichia coli O157:H7 str. EDL933 galactitol-1-phosphate dehydrogenase NP_288593.1 2915595 R 155864 CDS NP_288594.1 15802567 959443 complement(2916683..2918038) 1 NC_002655.2 PTS system galactitol-specific enzyme IIC 2918038 gatC 959443 gatC Escherichia coli O157:H7 str. EDL933 PTS system galactitol-specific enzyme IIC NP_288594.1 2916683 R 155864 CDS NP_288595.1 15802568 959320 complement(2918042..2918326) 1 NC_002655.2 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIB 2918326 gatB 959320 gatB Escherichia coli O157:H7 str. EDL933 PTS system galactitol-specific transporter subunit IIB NP_288595.1 2918042 R 155864 CDS NP_288596.1 15802569 956751 complement(2918357..2918809) 1 NC_002655.2 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIA 2918809 gatA 956751 gatA Escherichia coli O157:H7 str. EDL933 PTS system galactitol-specific transporter subunit IIA NP_288596.1 2918357 R 155864 CDS NP_288597.1 15802570 961356 complement(2918819..2920081) 1 NC_002655.2 tagatose 6-phosphate kinase 1 2920081 gatZ 961356 gatZ Escherichia coli O157:H7 str. EDL933 tagatose 6-phosphate kinase 1 NP_288597.1 2918819 R 155864 CDS NP_288598.2 161367577 956817 complement(2920110..2920964) 1 NC_002655.2 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 2920964 gatY 956817 gatY Escherichia coli O157:H7 str. EDL933 tagatose-bisphosphate aldolase NP_288598.2 2920110 R 155864 CDS NP_288599.2 161367576 956818 complement(2921263..2922315) 1 NC_002655.2 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate; fructose-bisphosphate aldolase 2922315 956818 Z3260 Escherichia coli O157:H7 str. EDL933 fructose-bisphosphate aldolase NP_288599.2 2921263 R 155864 CDS NP_288600.1 15802573 956819 2922573..2923850 1 NC_002655.2 nucleoside permease 2923850 yegT 956819 yegT Escherichia coli O157:H7 str. EDL933 nucleoside permease NP_288600.1 2922573 D 155864 CDS NP_288601.1 15802574 956838 2923847..2924851 1 NC_002655.2 hypothetical protein 2924851 956838 Z3262 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288601.1 2923847 D 155864 CDS NP_288602.1 15802575 960980 2924848..2925813 1 NC_002655.2 kinase 2925813 960980 Z3263 Escherichia coli O157:H7 str. EDL933 kinase NP_288602.1 2924848 D 155864 CDS NP_288603.1 15802576 956824 complement(2925787..2926533) 1 NC_002655.2 transcriptional regulator 2926533 yegW 956824 yegW Escherichia coli O157:H7 str. EDL933 transcriptional regulator NP_288603.1 2925787 R 155864 CDS NP_288604.1 15802577 956825 complement(2926585..2927412) 1 NC_002655.2 hypothetical protein 2927412 yegX 956825 yegX Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288604.1 2926585 R 155864 CDS NP_288605.1 15802578 956831 complement(2927468..2928268) 1 NC_002655.2 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 2928268 thiD 956831 thiD Escherichia coli O157:H7 str. EDL933 phosphomethylpyrimidine kinase NP_288605.1 2927468 R 155864 CDS NP_288606.1 15802579 956840 complement(2928265..2929053) 1 NC_002655.2 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 2929053 thiM 956840 thiM Escherichia coli O157:H7 str. EDL933 hydroxyethylthiazole kinase NP_288606.1 2928265 R 155864 CDS NP_288607.1 15802580 956846 2929387..2929626 1 NC_002655.2 No significant matches; hypothetical protein 2929626 956846 Z3269 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288607.1 2929387 D 155864 CDS NP_288608.1 15802581 961426 complement(2930190..2930309) 1 NC_002655.2 No significant matches; hypothetical protein 2930309 961426 Z3270 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288608.1 2930190 R 155864 CDS NP_288609.1 15802582 961346 2930677..2931024 1 NC_002655.2 No significant matches; hypothetical protein 2931024 961346 Z3271 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288609.1 2930677 D 155864 CDS NP_288610.1 15802583 956848 2931034..2931348 1 NC_002655.2 No significant matches; hypothetical protein 2931348 956848 Z3272 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288610.1 2931034 D 155864 CDS NP_288611.1 15802584 957814 complement(2931458..2931730) 1 NC_002655.2 hypothetical protein 2931730 yohL 957814 yohL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288611.1 2931458 R 155864 CDS NP_288612.1 15802585 956851 2931851..2932702 1 NC_002655.2 membrane protein conferring nickel and cobalt resistance; nickel/cobalt efflux protein RcnA 2932702 yohM 956851 yohM Escherichia coli O157:H7 str. EDL933 nickel/cobalt efflux protein RcnA NP_288612.1 2931851 D 155864 CDS NP_288613.1 15802586 956854 2932740..2933258 1 NC_002655.2 hypothetical protein 2933258 956854 Z3275 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288613.1 2932740 D 155864 CDS NP_288614.1 15802587 957303 complement(2933340..2934374) 1 NC_002655.2 fimbrial protein 2934374 957303 Z3276 Escherichia coli O157:H7 str. EDL933 fimbrial protein NP_288614.1 2933340 R 155864 CDS NP_288615.1 15802588 958121 complement(2934385..2936865) 1 NC_002655.2 hypothetical protein 2936865 yehB 958121 yehB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288615.1 2934385 R 155864 CDS NP_288616.1 15802589 956856 complement(2936881..2937603) 1 NC_002655.2 chaperone protein 2937603 yehC 956856 yehC Escherichia coli O157:H7 str. EDL933 chaperone protein NP_288616.1 2936881 R 155864 CDS NP_288617.1 15802590 956858 complement(2937643..2938185) 1 NC_002655.2 fimbrial-like protein 2938185 yehD 956858 yehD Escherichia coli O157:H7 str. EDL933 fimbrial-like protein NP_288617.1 2937643 R 155864 CDS NP_288618.1 15802591 956869 complement(2938477..2938758) 1 NC_002655.2 hypothetical protein 2938758 yehE 956869 yehE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288618.1 2938477 R 155864 CDS NP_288619.2 161367575 956870 complement(2939020..2940129) 1 NC_002655.2 ATPase 2940129 mrp 956870 mrp Escherichia coli O157:H7 str. EDL933 ATPase NP_288619.2 2939020 R 155864 CDS NP_288620.1 15802593 956881 2940261..2942294 1 NC_002655.2 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 2942294 metG 956881 metG Escherichia coli O157:H7 str. EDL933 methionyl-tRNA synthetase NP_288620.1 2940261 D 155864 CDS NP_288621.1 15802594 959445 2942435..2943163 1 NC_002655.2 hypothetical protein 2943163 molR_A 959445 molR_A Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288621.1 2942435 D 155864 CDS NP_288622.1 15802595 959384 2943353..2946244 1 NC_002655.2 hypothetical protein 2946244 molR_B 959384 molR_B Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288622.1 2943353 D 155864 CDS NP_288623.1 15802596 956672 2946257..2947537 1 NC_002655.2 hypothetical protein 2947537 molR_C 956672 molR_C Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288623.1 2946257 D 155864 CDS NP_288624.1 15802597 956882 2947503..2949242 1 NC_002655.2 hypothetical protein 2949242 molR_D 956882 molR_D Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288624.1 2947503 D 155864 CDS NP_288625.1 15802598 956885 2949252..2952881 1 NC_002655.2 regulator 2952881 yehI 956885 yehI Escherichia coli O157:H7 str. EDL933 regulator NP_288625.1 2949252 D 155864 CDS NP_288626.1 15802599 956886 2952943..2953260 1 NC_002655.2 hypothetical protein 2953260 yehK 956886 yehK Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288626.1 2952943 D 155864 CDS NP_288629.1 15802602 956890 2954435..2955589 1 NC_002655.2 hypothetical protein 2955589 yehL 956890 yehL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288629.1 2954435 D 155864 CDS NP_288630.1 15802603 956901 2955600..2957129 1 NC_002655.2 hypothetical protein 2957129 956901 Z3292 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288630.1 2955600 D 155864 CDS NP_288631.1 15802604 959414 2957148..2957879 1 NC_002655.2 hypothetical protein 2957879 959414 Z3293 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288631.1 2957148 D 155864 CDS NP_288632.1 15802605 956826 2957872..2959008 1 NC_002655.2 hypothetical protein 2959008 yehP 956826 yehP Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288632.1 2957872 D 155864 CDS NP_288633.1 15802606 959372 2959005..2961242 1 NC_002655.2 hypothetical protein 2961242 yehQ 959372 yehQ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288633.1 2959005 D 155864 CDS NP_288634.1 15802607 956904 complement(2961049..2961939) 1 NC_002655.2 transposase for IS629 2961939 956904 Z3297 Escherichia coli O157:H7 str. EDL933 transposase for IS629 NP_288634.1 2961049 R 155864 CDS NP_288635.1 15802608 956905 complement(2961936..2962262) 1 NC_002655.2 hypothetical protein 2962262 956905 Z3299 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288635.1 2961936 R 155864 CDS NP_288636.1 15802609 956908 2962434..2962907 1 NC_002655.2 hypothetical protein 2962907 yehR 956908 yehR Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288636.1 2962434 D 155864 CDS NP_288637.1 15802610 957157 complement(2962949..2963419) 1 NC_002655.2 hypothetical protein 2963419 yehS 957157 yehS Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288637.1 2962949 R 155864 CDS NP_288638.1 15802611 959558 complement(2963466..2964200) 1 NC_002655.2 unknown function; when overproduced it confers drug-resistance; two-component response-regulatory protein YehT 2964200 yehT 959558 yehT Escherichia coli O157:H7 str. EDL933 two-component response-regulatory protein YehT NP_288638.1 2963466 R 155864 CDS NP_288639.1 15802612 956913 complement(2964182..2965867) 1 NC_002655.2 2-component sensor protein 2965867 yehU 956913 yehU Escherichia coli O157:H7 str. EDL933 2-component sensor protein NP_288639.1 2964182 R 155864 CDS NP_288640.1 15802613 956918 2966382..2966630 1 NC_002655.2 hypothetical protein 2966630 956918 Z3305 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288640.1 2966382 D 155864 CDS NP_288641.1 15802614 956920 complement(2966998..2967267) 1 NC_002655.2 hypothetical protein 2967267 956920 Z3306 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288641.1 2966998 R 155864 CDS NP_288642.1 15802615 956923 complement(2967269..2967547) 1 NC_002655.2 tail fiber protein encoded within prophage CP-933V 2967547 956923 Z3307 Escherichia coli O157:H7 str. EDL933 tail fiber protein encoded within prophage CP-933V NP_288642.1 2967269 R 155864 CDS NP_288643.1 15802616 956925 complement(2967774..2968589) 1 NC_002655.2 tail fiber protein encoded within prophage CP-933V 2968589 956925 Z3309 Escherichia coli O157:H7 str. EDL933 tail fiber protein encoded within prophage CP-933V NP_288643.1 2967774 R 155864 CDS NP_288644.1 15802617 960805 complement(2968648..2969247) 1 NC_002655.2 Lom-like outer membrane protein of prophage CP-933V 2969247 960805 Z3310 Escherichia coli O157:H7 str. EDL933 Lom-like outer membrane protein of prophage CP-933V NP_288644.1 2968648 R 155864 CDS NP_288645.1 15802618 958961 complement(2969318..2972815) 1 NC_002655.2 tail fiber protein of prophage CP-933V 2972815 958961 Z3311 Escherichia coli O157:H7 str. EDL933 tail fiber protein of prophage CP-933V NP_288645.1 2969318 R 155864 CDS NP_288646.1 15802619 957692 2972490..2973476 1 NC_002655.2 superoxide dismutase 2973476 957692 Z3312 Escherichia coli O157:H7 str. EDL933 superoxide dismutase NP_288646.1 2972490 D 155864 CDS NP_288647.1 15802620 958214 complement(2973667..2974347) 1 NC_002655.2 tail component of prophage CP-933V 2974347 958214 Z3313 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933V NP_288647.1 2973667 R 155864 CDS NP_288648.1 15802621 956926 complement(2974245..2974919) 1 NC_002655.2 tail component of prophage CP-933V 2974919 956926 Z3314 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933V NP_288648.1 2974245 R 155864 CDS NP_288649.1 15802622 959525 complement(2974999..2975697) 1 NC_002655.2 tail component of prophage CP-933V 2975697 959525 Z3315 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933V NP_288649.1 2974999 R 155864 CDS NP_288650.1 15802623 956924 complement(2976031..2976207) 1 NC_002655.2 No significant matches; hypothetical protein 2976207 956924 Z3316 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288650.1 2976031 R 155864 CDS NP_288651.1 15802624 957148 complement(2976204..2979113) 1 NC_002655.2 tail component of prophage CP-933V 2979113 957148 Z3318 Escherichia coli O157:H7 str. EDL933 tail component of prophage CP-933V NP_288651.1 2976204 R 155864 CDS NP_288652.1 15802625 956929 complement(2979166..2979447) 1 NC_002655.2 hypothetical protein 2979447 956929 Z3319 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288652.1 2979166 R 155864 CDS NP_288653.1 15802626 956933 complement(2979471..2979845) 1 NC_002655.2 hypothetical protein 2979845 956933 Z3320 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288653.1 2979471 R 155864 CDS NP_288654.1 15802627 956998 complement(2979851..2980696) 1 NC_002655.2 major tail subunit encoded within prophage CP-933V 2980696 956998 Z3322 Escherichia coli O157:H7 str. EDL933 major tail subunit encoded within prophage CP-933V NP_288654.1 2979851 R 155864 CDS NP_288655.1 15802628 959606 complement(2980626..2980970) 1 NC_002655.2 hypothetical protein 2980970 959606 Z3323 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288655.1 2980626 R 155864 CDS NP_288656.1 15802629 956937 complement(2980967..2981413) 1 NC_002655.2 hypothetical protein 2981413 956937 Z3325 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288656.1 2980967 R 155864 CDS NP_288657.1 15802630 956949 complement(2981410..2981760) 1 NC_002655.2 hypothetical protein 2981760 956949 Z3326 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288657.1 2981410 R 155864 CDS NP_288658.1 15802631 956951 complement(2981770..2982096) 1 NC_002655.2 No significant matches; hypothetical protein 2982096 956951 Z3327 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288658.1 2981770 R 155864 CDS NP_288659.1 15802632 959455 complement(2982093..2984678) 1 NC_002655.2 portal protein for prophage CP-933V 2984678 959455 Z3328 Escherichia coli O157:H7 str. EDL933 portal protein for prophage CP-933V NP_288659.1 2982093 R 155864 CDS NP_288660.1 15802633 958114 complement(2984624..2984845) 1 NC_002655.2 No significant matches; hypothetical protein 2984845 958114 Z3329 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288660.1 2984624 R 155864 CDS NP_288661.1 15802634 957098 complement(2984890..2986827) 1 NC_002655.2 hypothetical protein 2986827 957098 Z3331 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288661.1 2984890 R 155864 CDS NP_288662.1 15802635 957299 complement(2986891..2988552) 1 NC_002655.2 hypothetical protein 2988552 957299 Z3332 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288662.1 2986891 R 155864 CDS NP_288663.2 157267362 956954 complement(2988549..2989112) 1 NC_002655.2 No significant matches; hypothetical protein 2989112 956954 Z3333 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288663.2 2988549 R 155864 CDS NP_288664.1 15802637 956955 2989505..2989750 1 NC_002655.2 No significant matches; hypothetical protein 2989750 956955 Z3334 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288664.1 2989505 D 155864 CDS NP_288665.1 15802638 956957 2989810..2990037 1 NC_002655.2 hypothetical protein 2990037 956957 Z3335 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288665.1 2989810 D 155864 CDS NP_288666.2 157267363 956965 complement(2990402..2990869) 1 NC_002655.2 endopeptidase Rz for prophage CP-933V 2990869 956965 Z3336 Escherichia coli O157:H7 str. EDL933 endopeptidase Rz for prophage CP-933V NP_288666.2 2990402 R 155864 CDS NP_288667.1 15802640 956718 complement(2991023..2991592) 1 NC_002655.2 antirepressor of prophage CP-933V 2991592 antV 956718 antV Escherichia coli O157:H7 str. EDL933 antirepressor of prophage CP-933V NP_288667.1 2991023 R 155864 CDS NP_288668.1 15802641 958284 complement(2991863..2992396) 1 NC_002655.2 No significant matches; endolysin R of prophage CP-933V 2992396 958284 Z3339 Escherichia coli O157:H7 str. EDL933 endolysin R of prophage CP-933V NP_288668.1 2991863 R 155864 CDS NP_288669.1 15802642 959522 complement(2992401..2992673) 1 NC_002655.2 lysis protein S of prophage CP-933V 2992673 959522 Z3340 Escherichia coli O157:H7 str. EDL933 lysis protein S of prophage CP-933V NP_288669.1 2992401 R 155864 CDS NP_288670.1 15802643 956966 complement(2992694..2993113) 1 NC_002655.2 hypothetical protein 2993113 956966 Z3341 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288670.1 2992694 R 155864 CDS NP_288671.1 15802644 958100 complement(2993297..2995243) 1 NC_002655.2 hypothetical protein 2995243 958100 Z3342 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288671.1 2993297 R 155864 CDS NP_288672.1 15802645 956702 complement(2995754..2996023) 1 NC_002655.2 shiga-like toxin 1 subunit B encoded within prophage CP-933V 2996023 stx1B 956702 stx1B Escherichia coli O157:H7 str. EDL933 shiga-like toxin 1 subunit B encoded within prophage CP-933V NP_288672.1 2995754 R 155864 CDS NP_288673.1 15802646 956968 complement(2996033..2996980) 1 NC_002655.2 shiga-like toxin 1 subunit A encoded within prophage CP-933V 2996980 stx1A 956968 stx1A Escherichia coli O157:H7 str. EDL933 shiga-like toxin 1 subunit A encoded within prophage CP-933V NP_288673.1 2996033 R 155864 CDS NP_288674.1 15802647 956970 complement(2997487..2997921) 1 NC_002655.2 antitermination protein Q for prophage CP-933V 2997921 956970 Z3345 Escherichia coli O157:H7 str. EDL933 antitermination protein Q for prophage CP-933V NP_288674.1 2997487 R 155864 CDS NP_288675.1 15802648 956976 complement(2998105..2998710) 1 NC_002655.2 hypothetical protein 2998710 956976 Z3346 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288675.1 2998105 R 155864 CDS NP_288676.1 15802649 961324 complement(2998703..2998777) 1 NC_002655.2 hypothetical protein 2998777 961324 Z3347 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288676.1 2998703 R 155864 CDS NP_288677.1 15802650 956687 complement(2998872..2999303) 1 NC_002655.2 No significant matches; hypothetical protein 2999303 956687 Z3348 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288677.1 2998872 R 155864 CDS NP_288678.1 15802651 956991 complement(2999449..2999976) 1 NC_002655.2 DNA methyltransferase encoded within prophage CP-933V 2999976 956991 Z3349 Escherichia coli O157:H7 str. EDL933 DNA methyltransferase encoded within prophage CP-933V NP_288678.1 2999449 R 155864 CDS NP_288679.1 15802652 956992 complement(2999973..3000419) 1 NC_002655.2 hypothetical protein 3000419 956992 Z3351 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288679.1 2999973 R 155864 CDS NP_288680.1 15802653 957004 complement(3000443..3000802) 1 NC_002655.2 hypothetical protein 3000802 957004 Z3352 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288680.1 3000443 R 155864 CDS NP_288681.1 15802654 957007 complement(3000972..3001250) 1 NC_002655.2 hypothetical protein 3001250 957007 Z3353 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288681.1 3000972 R 155864 CDS NP_288682.1 15802655 957013 complement(3001321..3001611) 1 NC_002655.2 No significant matches; exclusion protein ren of prophage CP-933V 3001611 957013 Z3354 Escherichia coli O157:H7 str. EDL933 exclusion protein ren of prophage CP-933V NP_288682.1 3001321 R 155864 CDS NP_288683.1 15802656 958844 complement(3001608..3002309) 1 NC_002655.2 DNA replication protein P of prophage CP-933V 3002309 958844 Z3355 Escherichia coli O157:H7 str. EDL933 DNA replication protein P of prophage CP-933V NP_288683.1 3001608 R 155864 CDS NP_288684.1 15802657 957881 complement(3002306..3003244) 1 NC_002655.2 DNA replication protein O of prophage CP-933V 3003244 957881 Z3356 Escherichia coli O157:H7 str. EDL933 DNA replication protein O of prophage CP-933V NP_288684.1 3002306 R 155864 CDS NP_288685.1 15802658 957015 complement(3003277..3003573) 1 NC_002655.2 regulatory protein CII of prophage CP-933V 3003573 957015 Z3357 Escherichia coli O157:H7 str. EDL933 regulatory protein CII of prophage CP-933V NP_288685.1 3003277 R 155864 CDS NP_288686.1 15802659 961320 3004015..3004662 1 NC_002655.2 repressor protein CI of prophage CP-933V 3004662 961320 Z3358 Escherichia coli O157:H7 str. EDL933 repressor protein CI of prophage CP-933V NP_288686.1 3004015 D 155864 CDS NP_288687.1 15802660 959494 3004785..3004892 1 NC_002655.2 No significant matches; hypothetical protein 3004892 959494 Z3359 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288687.1 3004785 D 155864 CDS NP_288688.1 15802661 960216 3005074..3005625 1 NC_002655.2 No significant matches; hypothetical protein 3005625 960216 Z3360 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288688.1 3005074 D 155864 CDS NP_288689.1 15802662 959309 3006138..3006410 1 NC_002655.2 transcription antitermination protein N of prophage CP-933V 3006410 959309 Z3361 Escherichia coli O157:H7 str. EDL933 transcription antitermination protein N of prophage CP-933V NP_288689.1 3006138 D 155864 CDS NP_288690.1 15802663 957017 complement(3006548..3007009) 1 NC_002655.2 superinfection exclusion protein B of prophage CP-933V 3007009 957017 Z3362 Escherichia coli O157:H7 str. EDL933 superinfection exclusion protein B of prophage CP-933V NP_288690.1 3006548 R 155864 CDS NP_288691.1 15802664 958548 3007270..3007638 1 NC_002655.2 ssDNA-binding protein 3007638 958548 Z3363 Escherichia coli O157:H7 str. EDL933 ssDNA-binding protein NP_288691.1 3007270 D 155864 CDS NP_288692.1 15802665 958550 3007718..3007987 1 NC_002655.2 host killing protein Kil of prophage CP-933V 3007987 958550 Z3364 Escherichia coli O157:H7 str. EDL933 host killing protein Kil of prophage CP-933V NP_288692.1 3007718 D 155864 CDS NP_288693.1 15802666 957029 3008063..3008359 1 NC_002655.2 host-nuclease inhibitor protein Gam of prophage CP-933V 3008359 957029 Z3365 Escherichia coli O157:H7 str. EDL933 host-nuclease inhibitor protein Gam of prophage CP-933V NP_288693.1 3008063 D 155864 CDS NP_288694.1 15802667 959532 3008365..3009150 1 NC_002655.2 recombination protein Bet of prophage CP-933V 3009150 959532 Z3366 Escherichia coli O157:H7 str. EDL933 recombination protein Bet of prophage CP-933V NP_288694.1 3008365 D 155864 CDS NP_288695.1 15802668 959500 3009147..3009824 1 NC_002655.2 exonuclease of prophage CP-933V 3009824 959500 Z3367 Escherichia coli O157:H7 str. EDL933 exonuclease of prophage CP-933V NP_288695.1 3009147 D 155864 CDS NP_288696.1 15802669 957000 3009979..3010170 1 NC_002655.2 hypothetical protein 3010170 957000 Z3368 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288696.1 3009979 D 155864 CDS NP_288697.1 15802670 957033 3010181..3010462 1 NC_002655.2 hypothetical protein 3010462 957033 Z3369 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288697.1 3010181 D 155864 CDS NP_288698.1 15802671 957042 3010779..3011726 1 NC_002655.2 hypothetical protein 3011726 957042 Z3370 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288698.1 3010779 D 155864 CDS NP_288699.1 15802672 956994 3012238..3012594 1 NC_002655.2 hypothetical protein 3012594 956994 Z3371 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288699.1 3012238 D 155864 CDS NP_288700.1 15802673 961175 3012591..3012953 1 NC_002655.2 hypothetical protein 3012953 961175 Z3372 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288700.1 3012591 D 155864 CDS NP_288701.1 15802674 956963 3013095..3013283 1 NC_002655.2 No significant matches; hypothetical protein 3013283 956963 Z3373 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288701.1 3013095 D 155864 CDS NP_288702.1 15802675 957053 3013287..3013421 1 NC_002655.2 No significant matches; hypothetical protein 3013421 957053 Z3374 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288702.1 3013287 D 155864 CDS NP_288703.1 15802676 956722 3013728..3015014 1 NC_002655.2 integrase for prophage CP-933V 3015014 intV 956722 intV Escherichia coli O157:H7 str. EDL933 integrase for prophage CP-933V NP_288703.1 3013728 D 155864 CDS NP_288704.1 15802677 960500 3015089..3015736 1 NC_002655.2 transcriptional regulator 3015736 yehV 960500 yehV Escherichia coli O157:H7 str. EDL933 transcriptional regulator NP_288704.1 3015089 D 155864 CDS NP_288705.1 15802678 957747 complement(3015884..3016615) 1 NC_002655.2 transport system permease 3016615 yehW 957747 yehW Escherichia coli O157:H7 str. EDL933 transport system permease NP_288705.1 3015884 R 155864 CDS NP_288706.1 15802679 957426 complement(3016620..3017546) 1 NC_002655.2 ABC transporter ATP-binding protein 3017546 yehX 957426 yehX Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_288706.1 3016620 R 155864 CDS NP_288707.1 15802680 957055 complement(3017539..3018696) 1 NC_002655.2 transport system permease 3018696 yehY 957055 yehY Escherichia coli O157:H7 str. EDL933 transport system permease NP_288707.1 3017539 R 155864 CDS NP_288708.1 15802681 959451 complement(3018703..3019620) 1 NC_002655.2 transport system permease 3019620 yehZ 959451 yehZ Escherichia coli O157:H7 str. EDL933 transport system permease NP_288708.1 3018703 R 155864 CDS NP_288709.1 15802682 957679 complement(3019872..3022169) 1 NC_002655.2 beta-D-glucoside glucohydrolase 3022169 bglX 957679 bglX Escherichia coli O157:H7 str. EDL933 beta-D-glucoside glucohydrolase NP_288709.1 3019872 R 155864 CDS NP_288710.1 15802683 957060 3022365..3024080 1 NC_002655.2 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase 3024080 dld 957060 dld Escherichia coli O157:H7 str. EDL933 D-lactate dehydrogenase NP_288710.1 3022365 D 155864 CDS NP_288711.1 15802684 961422 complement(3024118..3025059) 1 NC_002655.2 specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7; D-alanyl-D-alanine endopeptidase 3025059 pbpG 961422 pbpG Escherichia coli O157:H7 str. EDL933 D-alanyl-D-alanine endopeptidase NP_288711.1 3024118 R 155864 CDS NP_288712.1 15802685 957376 complement(3025224..3025835) 1 NC_002655.2 hypothetical protein 3025835 yohC 957376 yohC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288712.1 3025224 R 155864 CDS NP_288713.1 15802686 957247 3025945..3026559 1 NC_002655.2 hypothetical protein 3026559 yohD 957247 yohD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288713.1 3025945 D 155864 CDS NP_288714.1 15802687 957061 complement(3026689..3027450) 1 NC_002655.2 acetoin dehydrogenase 3027450 yohF 957061 yohF Escherichia coli O157:H7 str. EDL933 acetoin dehydrogenase NP_288714.1 3026689 R 155864 CDS NP_288715.4 189458503 957062 complement(3027503..3028939) 1 NC_002655.2 may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance outer membrane protein MdtQ 3028939 yohG 957062 yohG Escherichia coli O157:H7 str. EDL933 multidrug resistance outer membrane protein MdtQ NP_288715.4 3027503 R 155864 CDS NP_288716.1 15802689 959452 complement(3029283..3029375) 1 NC_002655.2 No significant matches; hypothetical protein 3029375 959452 Z3388 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288716.1 3029283 R 155864 CDS NP_288717.1 15802690 957879 complement(3029633..3030583) 1 NC_002655.2 tRNA-dihydrouridine synthase C 3030583 yohI 957879 yohI Escherichia coli O157:H7 str. EDL933 tRNA-dihydrouridine synthase C NP_288717.1 3029633 R 155864 CDS NP_288718.1 15802691 957065 complement(3030743..3031936) 1 NC_002655.2 catalyzes the formation of catechol from salicylate; salicylate hydroxylase 3031936 957065 Z3390 Escherichia coli O157:H7 str. EDL933 salicylate hydroxylase NP_288718.1 3030743 R 155864 CDS NP_288719.1 15802692 957070 complement(3031951..3032598) 1 NC_002655.2 glutathione-S-transferase 3032598 957070 Z3391 Escherichia coli O157:H7 str. EDL933 glutathione-S-transferase NP_288719.1 3031951 R 155864 CDS NP_288720.1 15802693 957074 complement(3032604..3033305) 1 NC_002655.2 isomerase-decarboxylase 3033305 957074 Z3392 Escherichia coli O157:H7 str. EDL933 isomerase-decarboxylase NP_288720.1 3032604 R 155864 CDS NP_288721.1 15802694 957071 complement(3033320..3034348) 1 NC_002655.2 1,2-dioxygenase 3034348 957071 Z3393 Escherichia coli O157:H7 str. EDL933 1,2-dioxygenase NP_288721.1 3033320 R 155864 CDS NP_288722.1 15802695 959392 complement(3034360..3035718) 1 NC_002655.2 transporter 3035718 959392 Z3394 Escherichia coli O157:H7 str. EDL933 transporter NP_288722.1 3034360 R 155864 CDS NP_288723.1 15802696 957075 3035797..3036753 1 NC_002655.2 regulator 3036753 957075 Z3395 Escherichia coli O157:H7 str. EDL933 regulator NP_288723.1 3035797 D 155864 CDS NP_288724.1 15802697 957077 3036884..3037282 1 NC_002655.2 hypothetical protein 3037282 yohJ 957077 yohJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288724.1 3036884 D 155864 CDS NP_288725.1 15802698 957079 3037279..3037974 1 NC_002655.2 hypothetical protein 3037974 yohK 957079 yohK Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288725.1 3037279 D 155864 CDS NP_288726.2 157267365 957083 3038104..3038988 1 NC_002655.2 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 3038988 cdd 957083 cdd Escherichia coli O157:H7 str. EDL933 cytidine deaminase NP_288726.2 3038104 D 155864 CDS NP_288727.1 15802700 957084 3039138..3039857 1 NC_002655.2 hypothetical protein 3039857 sanA 957084 sanA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288727.1 3039138 D 155864 CDS NP_288728.1 15802701 957105 3039860..3040099 1 NC_002655.2 hypothetical protein 3040099 957105 Z3400 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288728.1 3039860 D 155864 CDS NP_288729.1 15802702 957019 3040293..3041531 1 NC_002655.2 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain; oxidoreductase 3041531 957019 Z3401 Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_288729.1 3040293 D 155864 CDS NP_288730.2 161367574 956984 3041525..3042760 1 NC_002655.2 catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines; dihydropyrimidine dehydrogenase 3042760 yeiA 956984 yeiA Escherichia coli O157:H7 str. EDL933 dihydropyrimidine dehydrogenase NP_288730.2 3041525 D 155864 CDS NP_288731.1 15802704 957108 complement(3043004..3044014) 1 NC_002655.2 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane protein 3044014 mglC 957108 mglC Escherichia coli O157:H7 str. EDL933 beta-methylgalactoside transporter inner membrane protein NP_288731.1 3043004 R 155864 CDS NP_288732.1 15802705 957113 complement(3044030..3045550) 1 NC_002655.2 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein 3045550 mglA 957113 mglA Escherichia coli O157:H7 str. EDL933 galactose/methyl galaxtoside transporter ATP-binding protein NP_288732.1 3044030 R 155864 CDS NP_288733.1 15802706 959466 complement(3045611..3046609) 1 NC_002655.2 galactose-binding transport protein; receptor for galactose taxis 3046609 mglB 959466 mglB Escherichia coli O157:H7 str. EDL933 galactose-binding transport protein; receptor for galactose taxis NP_288733.1 3045611 R 155864 CDS NP_288734.1 15802707 959368 complement(3046889..3047929) 1 NC_002655.2 negative regulator of the mglBAC operon for galactose utilization; DNA-binding transcriptional regulator GalS 3047929 galS 959368 galS Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator GalS NP_288734.1 3046889 R 155864 CDS NP_288735.2 161367573 959519 complement(3048071..3049228) 1 NC_002655.2 hypothetical protein 3049228 959519 Z3408 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288735.2 3048071 R 155864 CDS NP_288736.1 15802709 957115 complement(3049245..3049913) 1 NC_002655.2 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 3049913 folE 957115 folE Escherichia coli O157:H7 str. EDL933 GTP cyclohydrolase I NP_288736.1 3049245 R 155864 CDS NP_288737.1 15802710 959327 3050171..3051007 1 NC_002655.2 esterase 3051007 yeiG 959327 yeiG Escherichia coli O157:H7 str. EDL933 esterase NP_288737.1 3050171 D 155864 CDS NP_288738.1 15802711 956749 complement(3051039..3053018) 1 NC_002655.2 Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein; colicin I receptor 3053018 cirA 956749 cirA Escherichia coli O157:H7 str. EDL933 colicin I receptor NP_288738.1 3051039 R 155864 CDS NP_288739.1 15802712 957056 complement(3053310..3054779) 1 NC_002655.2 lysine transporter 3054779 lysP 957056 lysP Escherichia coli O157:H7 str. EDL933 lysine transporter NP_288739.1 3053310 R 155864 CDS NP_288740.1 15802713 957119 complement(3054984..3055865) 1 NC_002655.2 DNA-binding transcriptional regulator 3055865 yeiE 957119 yeiE Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator NP_288740.1 3054984 R 155864 CDS NP_288741.1 15802714 957967 3055964..3057013 1 NC_002655.2 hypothetical protein 3057013 yeiH 957967 yeiH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288741.1 3055964 D 155864 CDS NP_288742.1 15802715 959540 3057087..3057944 1 NC_002655.2 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 3057944 nfo 959540 nfo Escherichia coli O157:H7 str. EDL933 endonuclease IV NP_288742.1 3057087 D 155864 CDS NP_288743.1 15802716 959355 3057947..3059035 1 NC_002655.2 hypothetical protein 3059035 yeiI 959355 yeiI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288743.1 3057947 D 155864 CDS NP_288744.1 15802717 959542 complement(3059091..3060332) 1 NC_002655.2 transport system permease 3060332 yeiJ 959542 yeiJ Escherichia coli O157:H7 str. EDL933 transport system permease NP_288744.1 3059091 R 155864 CDS NP_288745.1 15802718 957121 complement(3060441..3061382) 1 NC_002655.2 Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively; ribonucleoside hydrolase 2 3061382 rihB 957121 rihB Escherichia coli O157:H7 str. EDL933 ribonucleoside hydrolase 2 NP_288745.1 3060441 R 155864 CDS NP_288746.1 15802719 957264 3061551..3062210 1 NC_002655.2 activator of nucleoside metabolism; DNA-binding transcriptional activator YeiL 3062210 yeiL 957264 yeiL Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional activator YeiL NP_288746.1 3061551 D 155864 CDS NP_288747.1 15802720 961179 complement(3062281..3063531) 1 NC_002655.2 transport system permease 3063531 yeiM 961179 yeiM Escherichia coli O157:H7 str. EDL933 transport system permease NP_288747.1 3062281 R 155864 CDS NP_288748.1 15802721 957764 complement(3063625..3064563) 1 NC_002655.2 hypothetical protein 3064563 yeiN 957764 yeiN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288748.1 3063625 R 155864 CDS NP_288749.1 15802722 959203 complement(3064551..3065492) 1 NC_002655.2 hypothetical protein 3065492 yeiC 959203 yeiC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288749.1 3064551 R 155864 CDS NP_288750.1 15802723 957126 complement(3065916..3067607) 1 NC_002655.2 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system fructose-specific transporter subunit IIBC 3067607 fruA 957126 fruA Escherichia coli O157:H7 str. EDL933 PTS system fructose-specific transporter subunit IIBC NP_288750.1 3065916 R 155864 CDS NP_288751.1 15802724 959326 complement(3067624..3068562) 1 NC_002655.2 converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase 3068562 fruK 959326 fruK Escherichia coli O157:H7 str. EDL933 1-phosphofructokinase NP_288751.1 3067624 R 155864 CDS NP_288752.1 15802725 958260 complement(3068562..3069692) 1 NC_002655.2 phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein 3069692 fruB 958260 fruB Escherichia coli O157:H7 str. EDL933 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein NP_288752.1 3068562 R 155864 CDS NP_288753.1 15802726 957127 3070060..3071241 1 NC_002655.2 transport 3071241 yeiO 957127 yeiO Escherichia coli O157:H7 str. EDL933 transport NP_288753.1 3070060 D 155864 CDS NP_288754.2 161367572 957283 3071647..3072219 1 NC_002655.2 Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein; elongation factor P 3072219 yeiP 957283 yeiP Escherichia coli O157:H7 str. EDL933 elongation factor P NP_288754.2 3071647 D 155864 CDS NP_288755.1 15802728 956940 3072442..3073908 1 NC_002655.2 oxidoreductase 3073908 yeiQ 956940 yeiQ Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_288755.1 3072442 D 155864 CDS NP_288756.1 15802729 959298 3074026..3075012 1 NC_002655.2 hypothetical protein 3075012 yeiR 959298 yeiR Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288756.1 3074026 D 155864 CDS NP_288757.1 15802730 957393 3075015..3075764 1 NC_002655.2 hypothetical protein 3075764 957393 Z3433 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288757.1 3075015 D 155864 CDS NP_288758.1 15802731 957128 3076177..3076743 1 NC_002655.2 by similarity, Spr seems to have peptidase activity; involved in thermoresistance; outer membrane lipoprotein 3076743 spr 957128 spr Escherichia coli O157:H7 str. EDL933 outer membrane lipoprotein NP_288758.1 3076177 D 155864 CDS NP_288759.1 15802732 957134 3076925..3078481 1 NC_002655.2 hypothetical protein 3078481 rtn 957134 rtn Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288759.1 3076925 D 155864 CDS NP_288760.2 161367571 957136 3078563..3080377 1 NC_002655.2 hypothetical protein 3080377 yejA 957136 yejA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288760.2 3078563 D 155864 CDS NP_288761.1 15802734 957359 3080378..3081472 1 NC_002655.2 transport system permease 3081472 yejB 957359 yejB Escherichia coli O157:H7 str. EDL933 transport system permease NP_288761.1 3080378 D 155864 CDS NP_288762.1 15802735 957403 3081472..3082497 1 NC_002655.2 transport system permease 3082497 yejE 957403 yejE Escherichia coli O157:H7 str. EDL933 transport system permease NP_288762.1 3081472 D 155864 CDS NP_288763.1 15802736 958086 3082499..3084088 1 NC_002655.2 ABC transporter ATP-binding protein 3084088 yejF 958086 yejF Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_288763.1 3082499 D 155864 CDS NP_288764.1 15802737 957142 complement(3084092..3084436) 1 NC_002655.2 hypothetical protein 3084436 yejG 957142 yejG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288764.1 3084092 R 155864 CDS NP_288765.1 15802738 959264 complement(3084769..3085959) 1 NC_002655.2 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system protein 3085959 bcr 959264 bcr Escherichia coli O157:H7 str. EDL933 bicyclomycin/multidrug efflux system protein NP_288765.1 3084769 R 155864 CDS NP_288766.1 15802739 959609 complement(3085987..3086682) 1 NC_002655.2 catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA; 16S rRNA pseudouridylate synthase A 3086682 rsuA 959609 rsuA Escherichia coli O157:H7 str. EDL933 16S rRNA pseudouridylate synthase A NP_288766.1 3085987 R 155864 CDS NP_288767.1 15802740 961287 3086831..3088591 1 NC_002655.2 ATP-dependent helicase 3088591 yejH 961287 yejH Escherichia coli O157:H7 str. EDL933 ATP-dependent helicase NP_288767.1 3086831 D 155864 CDS NP_288768.1 15802741 957144 3088716..3089000 1 NC_002655.2 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 3089000 rplY 957144 rplY Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L25 NP_288768.1 3088716 D 155864 CDS NP_288769.1 15802742 957153 complement(3089139..3090146) 1 NC_002655.2 nucleoid-associated protein NdpA 3090146 yejK 957153 yejK Escherichia coli O157:H7 str. EDL933 nucleoid-associated protein NdpA NP_288769.1 3089139 R 155864 CDS NP_288770.1 15802743 957154 3090328..3090555 1 NC_002655.2 hypothetical protein 3090555 yejL 957154 yejL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288770.1 3090328 D 155864 CDS NP_288771.1 15802744 957420 3090575..3092335 1 NC_002655.2 sulfatase 3092335 yejM 957420 yejM Escherichia coli O157:H7 str. EDL933 sulfatase NP_288771.1 3090575 D 155864 CDS NP_288772.1 15802745 957156 complement(3092587..3095097) 1 NC_002655.2 ABC transporter ATP-binding protein 3095097 yejO 957156 yejO Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_288772.1 3092587 R 155864 CDS NP_288773.1 15802746 959502 3095498..3096145 1 NC_002655.2 nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes; transcriptional regulator NarP 3096145 narP 959502 narP Escherichia coli O157:H7 str. EDL933 transcriptional regulator NarP NP_288773.1 3095498 D 155864 CDS NP_288774.1 15802747 959377 complement(3096180..3097232) 1 NC_002655.2 subunit of heme lyase 3097232 ccmH 959377 ccmH Escherichia coli O157:H7 str. EDL933 subunit of heme lyase NP_288774.1 3096180 R 155864 CDS NP_288775.1 15802748 959498 complement(3097229..3097786) 1 NC_002655.2 disulfide oxidoreductase 3097786 dsbE 959498 dsbE Escherichia coli O157:H7 str. EDL933 disulfide oxidoreductase NP_288775.1 3097229 R 155864 CDS NP_288776.1 15802749 957050 complement(3097783..3099726) 1 NC_002655.2 cytochrome C biogenesis protein 3099726 ccmF 957050 ccmF Escherichia coli O157:H7 str. EDL933 cytochrome C biogenesis protein NP_288776.1 3097783 R 155864 CDS NP_288777.1 15802750 957167 complement(3099723..3100202) 1 NC_002655.2 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome C biogenesis protein CcmE 3100202 ccmE 957167 ccmE Escherichia coli O157:H7 str. EDL933 cytochrome C biogenesis protein CcmE NP_288777.1 3099723 R 155864 CDS NP_288778.1 15802751 957172 complement(3100199..3100408) 1 NC_002655.2 heme exporter protein C 3100408 ccmD 957172 ccmD Escherichia coli O157:H7 str. EDL933 heme exporter protein C NP_288778.1 3100199 R 155864 CDS NP_288779.1 15802752 957176 complement(3100405..3101142) 1 NC_002655.2 heme exporter protein C 3101142 ccmC 957176 ccmC Escherichia coli O157:H7 str. EDL933 heme exporter protein C NP_288779.1 3100405 R 155864 CDS NP_288780.1 15802753 957177 complement(3101184..3101846) 1 NC_002655.2 heme exporter protein B, cytochrome C biogenesis protein 3101846 ccmB 957177 ccmB Escherichia coli O157:H7 str. EDL933 heme exporter protein B, cytochrome C biogenesis protein NP_288780.1 3101184 R 155864 CDS NP_288781.1 15802754 957178 complement(3101843..3102460) 1 NC_002655.2 ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA 3102460 ccmA 957178 ccmA Escherichia coli O157:H7 str. EDL933 cytochrome c biogenesis protein CcmA NP_288781.1 3101843 R 155864 CDS NP_288782.1 15802755 960378 complement(3102479..3103081) 1 NC_002655.2 with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone; cytochrome C 3103081 napC 960378 napC Escherichia coli O157:H7 str. EDL933 cytochrome C NP_288782.1 3102479 R 155864 CDS NP_288783.2 161367570 959552 complement(3103091..3103540) 1 NC_002655.2 small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA; citrate reductase cytochrome C subunit 3103540 napB 959552 napB Escherichia coli O157:H7 str. EDL933 citrate reductase cytochrome C subunit NP_288783.2 3103091 R 155864 CDS NP_288784.1 15802757 957268 complement(3103537..3104400) 1 NC_002655.2 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component 3104400 napH 957268 napH Escherichia coli O157:H7 str. EDL933 quinol dehydrogenase membrane component NP_288784.1 3103537 R 155864 CDS NP_288785.1 15802758 957182 complement(3104387..3105082) 1 NC_002655.2 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component 3105082 napG 957182 napG Escherichia coli O157:H7 str. EDL933 quinol dehydrogenase periplasmic component NP_288785.1 3104387 R 155864 CDS NP_288786.1 15802759 957183 complement(3105089..3107575) 1 NC_002655.2 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit 3107575 napA 957183 napA Escherichia coli O157:H7 str. EDL933 nitrate reductase catalytic subunit NP_288786.1 3105089 R 155864 CDS NP_288787.1 15802760 957465 complement(3107572..3107835) 1 NC_002655.2 assembly protein for periplasmic nitrate reductase 3107835 napD 957465 napD Escherichia coli O157:H7 str. EDL933 assembly protein for periplasmic nitrate reductase NP_288787.1 3107572 R 155864 CDS NP_288788.1 15802761 958901 complement(3107825..3108319) 1 NC_002655.2 Predicted role in electron transfer to the periplasmic nitrate reductase NapA.; ferredoxin-type protein 3108319 napF 958901 napF Escherichia coli O157:H7 str. EDL933 ferredoxin-type protein NP_288788.1 3107825 R 155864 CDS NP_288789.1 15802762 957186 3108726..3109214 1 NC_002655.2 serine protease inhibitor, inhibits trypsin and other proteases; ecotin 3109214 eco 957186 eco Escherichia coli O157:H7 str. EDL933 ecotin NP_288789.1 3108726 D 155864 CDS NP_288790.1 15802763 957188 complement(3109364..3111010) 1 NC_002655.2 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase 3111010 yojH 957188 yojH Escherichia coli O157:H7 str. EDL933 malate:quinone oxidoreductase NP_288790.1 3109364 R 155864 CDS NP_288791.1 15802764 961107 complement(3111228..3112871) 1 NC_002655.2 efflux pump for the antibacterial peptide microcin J25; multidrug transporter membrane protein/ATP-binding component 3112871 yojI 961107 yojI Escherichia coli O157:H7 str. EDL933 multidrug transporter membrane protein/ATP-binding component NP_288791.1 3111228 R 155864 CDS NP_288792.1 15802765 961035 complement(3112947..3113597) 1 NC_002655.2 DNA repair system specific for alkylated DNA 3113597 alkB 961035 alkB Escherichia coli O157:H7 str. EDL933 DNA repair system specific for alkylated DNA NP_288792.1 3112947 R 155864 CDS NP_288793.1 15802766 957191 complement(3113597..3114661) 1 NC_002655.2 O6-methylguanine-DNA methyltransferase; transcription activator/repressor 3114661 ada 957191 ada Escherichia coli O157:H7 str. EDL933 O6-methylguanine-DNA methyltransferase; transcription activator/repressor NP_288793.1 3113597 R 155864 CDS NP_288794.1 15802767 957195 complement(3114735..3115790) 1 NC_002655.2 catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway; thiamine biosynthesis lipoprotein ApbE 3115790 yojL 957195 yojL Escherichia coli O157:H7 str. EDL933 thiamine biosynthesis lipoprotein ApbE NP_288794.1 3114735 R 155864 CDS NP_288795.1 15802768 958280 complement(3115902..3117005) 1 NC_002655.2 allows for ions and hydrophilic solutes to cross the outer membrane; porin 3117005 ompC 958280 ompC Escherichia coli O157:H7 str. EDL933 porin NP_288795.1 3115902 R 155864 CDS NP_288796.1 15802769 961178 3117744..3120416 1 NC_002655.2 phosphotransfer intermediate protein in two-component regulatory system with RcsBC 3120416 yojN 961178 yojN Escherichia coli O157:H7 str. EDL933 phosphotransfer intermediate protein in two-component regulatory system with RcsBC NP_288796.1 3117744 D 155864 CDS NP_288797.1 15802770 961169 3120433..3121083 1 NC_002655.2 two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF; transcriptional regulator RcsB 3121083 rcsB 961169 rcsB Escherichia coli O157:H7 str. EDL933 transcriptional regulator RcsB NP_288797.1 3120433 D 155864 CDS NP_288798.2 161367569 957032 complement(3121283..3124132) 1 NC_002655.2 hybrid sensory kinase in two-component regulatory system with RcsB and YojN 3124132 rcsC 957032 rcsC Escherichia coli O157:H7 str. EDL933 hybrid sensory kinase in two-component regulatory system with RcsB and YojN NP_288798.2 3121283 R 155864 CDS NP_288799.1 15802772 956682 complement(3124407..3125183) 1 NC_002655.2 hypothetical protein 3125183 956682 Z3478 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288799.1 3124407 R 155864 CDS NP_288800.1 15802773 957161 complement(3125188..3125970) 1 NC_002655.2 hypothetical protein 3125970 957161 Z3479 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288800.1 3125188 R 155864 CDS NP_288801.1 15802774 957461 complement(3126043..3126837) 1 NC_002655.2 hypothetical protein 3126837 957461 Z3480 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288801.1 3126043 R 155864 CDS NP_288802.1 15802775 961302 complement(3126838..3131442) 1 NC_002655.2 hypothetical protein 3131442 961302 Z3481 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288802.1 3126838 R 155864 CDS NP_288803.2 228979046 957200 complement(3131376..3131999) 1 NC_002655.2 hypothetical protein 3131999 957200 Z3482 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288803.2 3131376 R 155864 CDS NP_288804.2 161367568 957203 complement(3131996..3133594) 1 NC_002655.2 hypothetical protein 3133594 yfaA 957203 yfaA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288804.2 3131996 R 155864 CDS NP_288805.1 15802778 957213 complement(3133832..3136459) 1 NC_002655.2 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 3136459 gyrA 957213 gyrA Escherichia coli O157:H7 str. EDL933 DNA gyrase subunit A NP_288805.1 3133832 R 155864 CDS NP_288806.1 15802779 958473 3136606..3137328 1 NC_002655.2 Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 3137328 ubiG 958473 ubiG Escherichia coli O157:H7 str. EDL933 3-demethylubiquinone-9 3-methyltransferase NP_288806.1 3136606 D 155864 CDS NP_288807.1 15802780 958126 complement(3137469..3141221) 1 NC_002655.2 adhesin 3141221 yfaL 958126 yfaL Escherichia coli O157:H7 str. EDL933 adhesin NP_288807.1 3137469 R 155864 CDS NP_288808.1 15802781 957217 3141917..3144202 1 NC_002655.2 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 3144202 nrdA 957217 nrdA Escherichia coli O157:H7 str. EDL933 ribonucleotide-diphosphate reductase subunit alpha NP_288808.1 3141917 D 155864 CDS NP_288809.1 15802782 957218 3144429..3145559 1 NC_002655.2 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 3145559 nrdB 957218 nrdB Escherichia coli O157:H7 str. EDL933 ribonucleotide-diphosphate reductase subunit beta NP_288809.1 3144429 D 155864 CDS NP_288810.1 15802783 957159 3145559..3145813 1 NC_002655.2 plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases; 2Fe-2S ferredoxin 3145813 yfaE 957159 yfaE Escherichia coli O157:H7 str. EDL933 2Fe-2S ferredoxin NP_288810.1 3145559 D 155864 CDS NP_288811.1 15802784 958448 complement(3145867..3146517) 1 NC_002655.2 hypothetical protein 3146517 inaA 958448 inaA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288811.1 3145867 R 155864 CDS NP_288812.1 15802785 957220 complement(3146598..3147788) 1 NC_002655.2 antibiotic efflux protein 3147788 957220 Z3494 Escherichia coli O157:H7 str. EDL933 antibiotic efflux protein NP_288812.1 3146598 R 155864 CDS NP_288813.1 15802786 957276 3147940..3148818 1 NC_002655.2 regulator 3148818 957276 Z3495 Escherichia coli O157:H7 str. EDL933 regulator NP_288813.1 3147940 D 155864 CDS NP_288814.1 15802787 957222 3149282..3150352 1 NC_002655.2 No significant matches; hypothetical protein 3150352 957222 Z3496 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288814.1 3149282 D 155864 CDS NP_288815.1 15802788 957223 complement(3150576..3151652) 1 NC_002655.2 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase 3151652 glpQ 957223 glpQ Escherichia coli O157:H7 str. EDL933 glycerophosphodiester phosphodiesterase NP_288815.1 3150576 R 155864 CDS NP_288816.1 15802789 957229 complement(3151657..3153015) 1 NC_002655.2 catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell; sn-glycerol-3-phosphate transporter 3153015 glpT 957229 glpT Escherichia coli O157:H7 str. EDL933 sn-glycerol-3-phosphate transporter NP_288816.1 3151657 R 155864 CDS NP_288817.1 15802790 959442 3153288..3154916 1 NC_002655.2 anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A 3154916 glpA 959442 glpA Escherichia coli O157:H7 str. EDL933 sn-glycerol-3-phosphate dehydrogenase subunit A NP_288817.1 3153288 D 155864 CDS NP_288818.1 15802791 956952 3154906..3156165 1 NC_002655.2 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 3156165 glpB 956952 glpB Escherichia coli O157:H7 str. EDL933 anaerobic glycerol-3-phosphate dehydrogenase subunit B NP_288818.1 3154906 D 155864 CDS NP_288819.1 15802792 959546 3156162..3157352 1 NC_002655.2 anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 3157352 glpC 959546 glpC Escherichia coli O157:H7 str. EDL933 sn-glycerol-3-phosphate dehydrogenase subunit C NP_288819.1 3156162 D 155864 CDS NP_288820.1 15802793 958312 3157545..3158471 1 NC_002655.2 hypothetical protein 3158471 yfaD 958312 yfaD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288820.1 3157545 D 155864 CDS NP_288821.1 15802794 957237 complement(3158512..3159264) 1 NC_002655.2 aldolase 3159264 957237 Z3503 Escherichia coli O157:H7 str. EDL933 aldolase NP_288821.1 3158512 R 155864 CDS NP_288822.1 15802795 957238 complement(3159332..3160660) 1 NC_002655.2 transporter 3160660 957238 Z3504 Escherichia coli O157:H7 str. EDL933 transporter NP_288822.1 3159332 R 155864 CDS NP_288823.1 15802796 959528 complement(3160678..3161895) 1 NC_002655.2 racemase 3161895 959528 Z3505 Escherichia coli O157:H7 str. EDL933 racemase NP_288823.1 3160678 R 155864 CDS NP_288824.1 15802797 959533 complement(3161898..3162680) 1 NC_002655.2 regulator 3162680 959533 Z3506 Escherichia coli O157:H7 str. EDL933 regulator NP_288824.1 3161898 R 155864 CDS NP_288825.1 15802798 960973 complement(3162900..3164102) 1 NC_002655.2 competence damage-inducible protein A 3164102 960973 Z3507 Escherichia coli O157:H7 str. EDL933 competence damage-inducible protein A NP_288825.1 3162900 R 155864 CDS NP_288826.1 15802799 957240 complement(3164202..3164765) 1 NC_002655.2 hypothetical protein 3164765 957240 Z3508 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288826.1 3164202 R 155864 CDS NP_288827.1 15802800 957241 3165023..3165448 1 NC_002655.2 hypothetical protein 3165448 yfaO 957241 yfaO Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288827.1 3165023 D 155864 CDS NP_288828.1 15802801 958508 complement(3165487..3166089) 1 NC_002655.2 protein induced by aluminum 3166089 ais 958508 ais Escherichia coli O157:H7 str. EDL933 protein induced by aluminum NP_288828.1 3165487 R 155864 CDS NP_288829.2 161367567 956897 3166397..3167536 1 NC_002655.2 catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose; UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase 3167536 956897 Z3511 Escherichia coli O157:H7 str. EDL933 UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase NP_288829.2 3166397 D 155864 CDS NP_288830.1 15802803 957251 3167540..3168508 1 NC_002655.2 catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate; undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase 3168508 957251 Z3512 Escherichia coli O157:H7 str. EDL933 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase NP_288830.1 3167540 D 155864 CDS NP_288831.1 15802804 957675 3168508..3170490 1 NC_002655.2 Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains; bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase 3170490 957675 Z3513 Escherichia coli O157:H7 str. EDL933 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase NP_288831.1 3168508 D 155864 CDS NP_288832.1 15802805 959273 3170487..3171377 1 NC_002655.2 hypothetical protein 3171377 959273 Z3514 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288832.1 3170487 D 155864 CDS NP_288833.1 15802806 957170 3171377..3173029 1 NC_002655.2 catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A; 4-amino-4-deoxy-L-arabinose transferase 3173029 arnT 957170 arnT Escherichia coli O157:H7 str. EDL933 4-amino-4-deoxy-L-arabinose transferase NP_288833.1 3171377 D 155864 CDS NP_288834.1 15802807 959301 3173026..3173361 1 NC_002655.2 No significant matches; hypothetical protein 3173361 959301 Z3516 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288834.1 3173026 D 155864 CDS NP_288835.2 161367566 957272 3173361..3173747 1 NC_002655.2 hypothetical protein 3173747 957272 Z3517 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288835.2 3173361 D 155864 CDS NP_288836.1 15802809 959289 complement(3173741..3174037) 1 NC_002655.2 polymyxin resistance protein B 3174037 pmrD 959289 pmrD Escherichia coli O157:H7 str. EDL933 polymyxin resistance protein B NP_288836.1 3173741 R 155864 CDS NP_288838.1 15802811 959419 complement(3174117..3175472) 1 NC_002655.2 O-succinylbenzoic acid--CoA ligase 3175472 menE 959419 menE Escherichia coli O157:H7 str. EDL933 O-succinylbenzoic acid--CoA ligase NP_288838.1 3174117 R 155864 CDS NP_288839.1 15802812 957275 complement(3175469..3176431) 1 NC_002655.2 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 3176431 menC 957275 menC Escherichia coli O157:H7 str. EDL933 O-succinylbenzoate synthase NP_288839.1 3175469 R 155864 CDS NP_288840.1 15802813 959317 complement(3176431..3177288) 1 NC_002655.2 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 3177288 menB 959317 menB Escherichia coli O157:H7 str. EDL933 naphthoate synthase NP_288840.1 3176431 R 155864 CDS NP_288841.1 15802814 957858 complement(3177303..3178061) 1 NC_002655.2 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase 3178061 yfbB 957858 yfbB Escherichia coli O157:H7 str. EDL933 acyl-CoA thioester hydrolase NP_288841.1 3177303 R 155864 CDS NP_288842.1 15802815 957277 complement(3178058..3179728) 1 NC_002655.2 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 3179728 menD 957277 menD Escherichia coli O157:H7 str. EDL933 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase NP_288842.1 3178058 R 155864 CDS NP_288843.3 189458504 957285 complement(3179817..3181112) 1 NC_002655.2 synthesizes isochorismate acid from chorismate; menaquinone-specific isochorismate synthase 3181112 menF 957285 menF Escherichia coli O157:H7 str. EDL933 menaquinone-specific isochorismate synthase NP_288843.3 3179817 R 155864 CDS NP_288844.1 15802817 961187 complement(3181191..3181496) 1 NC_002655.2 hypothetical protein 3181496 elaB 961187 elaB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288844.1 3181191 R 155864 CDS NP_288845.1 15802818 958335 complement(3181551..3182012) 1 NC_002655.2 hypothetical protein 3182012 elaA 958335 elaA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288845.1 3181551 R 155864 CDS NP_288846.2 161367564 957820 3182077..3182994 1 NC_002655.2 member of metallo-beta-lactamase; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 3182994 elaC 957820 elaC Escherichia coli O157:H7 str. EDL933 ribonuclease Z NP_288846.2 3182077 D 155864 CDS NP_288847.1 15802820 957300 3183182..3184405 1 NC_002655.2 ElaD; specific cysteine protease which targets ubiquitin and ubiquitin-like proteins covalently bound to target proteins; SseL in Salmonella is required for macrophage killing and virulence, and it is secreted by the salmonella pathogenicity island 2 type III secretion system; deubiquitinase 3184405 elaD 957300 elaD Escherichia coli O157:H7 str. EDL933 deubiquitinase NP_288847.1 3183182 D 155864 CDS NP_288848.1 15802821 957310 3185192..3185434 1 NC_002655.2 hypothetical protein 3185434 957310 Z3531 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288848.1 3185192 D 155864 CDS NP_288849.1 15802822 957316 3185537..3186040 1 NC_002655.2 hypothetical protein 3186040 yfbM 957316 yfbM Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288849.1 3185537 D 155864 CDS NP_288850.2 161367563 957323 complement(3186107..3187564) 1 NC_002655.2 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N 3187564 nuoN 957323 nuoN Escherichia coli O157:H7 str. EDL933 NADH dehydrogenase subunit N NP_288850.2 3186107 R 155864 CDS NP_288851.1 15802824 957330 complement(3187571..3189100) 1 NC_002655.2 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M 3189100 nuoM 957330 nuoM Escherichia coli O157:H7 str. EDL933 NADH dehydrogenase subunit M NP_288851.1 3187571 R 155864 CDS NP_288852.1 15802825 959531 complement(3189331..3191172) 1 NC_002655.2 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L 3191172 nuoL 959531 nuoL Escherichia coli O157:H7 str. EDL933 NADH dehydrogenase subunit L NP_288852.1 3189331 R 155864 CDS NP_288853.1 15802826 957520 complement(3191169..3191471) 1 NC_002655.2 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K 3191471 nuoK 957520 nuoK Escherichia coli O157:H7 str. EDL933 NADH dehydrogenase subunit K NP_288853.1 3191169 R 155864 CDS NP_288854.1 15802827 961418 complement(3191468..3192022) 1 NC_002655.2 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J 3192022 nuoJ 961418 nuoJ Escherichia coli O157:H7 str. EDL933 NADH dehydrogenase subunit J NP_288854.1 3191468 R 155864 CDS NP_288855.1 15802828 957341 complement(3192034..3192576) 1 NC_002655.2 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 3192576 nuoI 957341 nuoI Escherichia coli O157:H7 str. EDL933 NADH dehydrogenase subunit I NP_288855.1 3192034 R 155864 CDS NP_288856.1 15802829 956906 complement(3192591..3193568) 1 NC_002655.2 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H 3193568 nuoH 956906 nuoH Escherichia coli O157:H7 str. EDL933 NADH dehydrogenase subunit H NP_288856.1 3192591 R 155864 CDS NP_288857.1 15802830 957432 complement(3193565..3196297) 1 NC_002655.2 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G 3196297 nuoG 957432 nuoG Escherichia coli O157:H7 str. EDL933 NADH dehydrogenase subunit G NP_288857.1 3193565 R 155864 CDS NP_288858.1 15802831 959260 complement(3196344..3197681) 1 NC_002655.2 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase; NADH dehydrogenase I subunit F 3197681 nuoF 959260 nuoF Escherichia coli O157:H7 str. EDL933 NADH dehydrogenase I subunit F NP_288858.1 3196344 R 155864 CDS NP_288859.1 15802832 957351 complement(3197678..3198178) 1 NC_002655.2 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E 3198178 nuoE 957351 nuoE Escherichia coli O157:H7 str. EDL933 NADH dehydrogenase subunit E NP_288859.1 3197678 R 155864 CDS NP_288860.1 15802833 958352 complement(3198181..3199983) 1 NC_002655.2 NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms; bifunctional NADH:ubiquinone oxidoreductase subunit C/D 3199983 nuoC 958352 nuoC Escherichia coli O157:H7 str. EDL933 bifunctional NADH:ubiquinone oxidoreductase subunit C/D NP_288860.1 3198181 R 155864 CDS NP_288861.1 15802834 958339 complement(3200077..3200739) 1 NC_002655.2 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 3200739 nuoB 958339 nuoB Escherichia coli O157:H7 str. EDL933 NADH dehydrogenase subunit B NP_288861.1 3200077 R 155864 CDS NP_288862.1 15802835 957052 complement(3200755..3201198) 1 NC_002655.2 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A 3201198 nuoA 957052 nuoA Escherichia coli O157:H7 str. EDL933 NADH dehydrogenase subunit A NP_288862.1 3200755 R 155864 CDS NP_288863.1 15802836 957618 complement(3201829..3202767) 1 NC_002655.2 LysR family transcriptional regulator 3202767 lrhA 957618 lrhA Escherichia coli O157:H7 str. EDL933 LysR family transcriptional regulator NP_288863.1 3201829 R 155864 CDS NP_288864.1 15802837 957354 3203687..3204904 1 NC_002655.2 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase 3204904 957354 Z3551 Escherichia coli O157:H7 str. EDL933 aminotransferase NP_288864.1 3203687 D 155864 CDS NP_288865.1 15802838 957793 3204988..3205587 1 NC_002655.2 hypothetical protein 3205587 957793 Z3552 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288865.1 3204988 D 155864 CDS NP_288866.1 15802839 958204 complement(3205646..3207478) 1 NC_002655.2 transporter 3207478 yfbS 958204 yfbS Escherichia coli O157:H7 str. EDL933 transporter NP_288866.1 3205646 R 155864 CDS NP_288867.1 15802840 956786 complement(3207565..3208215) 1 NC_002655.2 phosphatase 3208215 yfbT 956786 yfbT Escherichia coli O157:H7 str. EDL933 phosphatase NP_288867.1 3207565 R 155864 CDS NP_288868.2 161367562 957358 complement(3208226..3208720) 1 NC_002655.2 hypothetical protein 3208720 957358 Z3555 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288868.2 3208226 R 155864 CDS NP_288869.1 15802842 957374 complement(3208803..3209258) 1 NC_002655.2 hypothetical protein 3209258 957374 Z3556 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288869.1 3208803 R 155864 CDS NP_288870.1 15802843 958184 3209596..3210798 1 NC_002655.2 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 3210798 ackA 958184 ackA Escherichia coli O157:H7 str. EDL933 acetate kinase NP_288870.1 3209596 D 155864 CDS NP_288871.1 15802844 959575 3210873..3213017 1 NC_002655.2 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 3213017 pta 959575 pta Escherichia coli O157:H7 str. EDL933 phosphate acetyltransferase NP_288871.1 3210873 D 155864 CDS NP_288872.2 161367561 957381 3213207..3214727 1 NC_002655.2 hypothetical protein 3214727 yfcC 957381 yfcC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288872.2 3213207 D 155864 CDS NP_288873.1 15802846 957158 complement(3214760..3215302) 1 NC_002655.2 regulator 3215302 957158 Z3561 Escherichia coli O157:H7 str. EDL933 regulator NP_288873.1 3214760 R 155864 CDS NP_288874.1 15802847 958187 complement(3215360..3215914) 1 NC_002655.2 phosphodiesterase 3215914 yfcE 958187 yfcE Escherichia coli O157:H7 str. EDL933 phosphodiesterase NP_288874.1 3215360 R 155864 CDS NP_288875.1 15802848 957386 complement(3215967..3216611) 1 NC_002655.2 hypothetical protein 3216611 yfcF 957386 yfcF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288875.1 3215967 R 155864 CDS NP_288876.1 15802849 959295 3216747..3217394 1 NC_002655.2 glutathione S-transferase 3217394 yfcG 959295 yfcG Escherichia coli O157:H7 str. EDL933 glutathione S-transferase NP_288876.1 3216747 D 155864 CDS NP_288877.1 15802850 958188 3217451..3217813 1 NC_002655.2 catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate; D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase 3217813 folX 958188 folX Escherichia coli O157:H7 str. EDL933 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase NP_288877.1 3217451 D 155864 CDS NP_288878.1 15802851 957388 3217834..3218727 1 NC_002655.2 sugar nucleotide epimerase 3218727 957388 Z3566 Escherichia coli O157:H7 str. EDL933 sugar nucleotide epimerase NP_288878.1 3217834 D 155864 CDS NP_288879.1 15802852 959027 complement(3218775..3219665) 1 NC_002655.2 hypothetical protein 3219665 yfcI 959027 yfcI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288879.1 3218775 R 155864 CDS NP_288880.1 15802853 961714 complement(3219862..3220635) 1 NC_002655.2 histidine/lysine/arginine/ornithine transporter subunit 3220635 hisP 961714 hisP Escherichia coli O157:H7 str. EDL933 histidine/lysine/arginine/ornithine transporter subunit NP_288880.1 3219862 R 155864 CDS NP_288881.1 15802854 957390 complement(3220643..3221359) 1 NC_002655.2 histidine transport, membrane protein M 3221359 hisM 957390 hisM Escherichia coli O157:H7 str. EDL933 histidine transport, membrane protein M NP_288881.1 3220643 R 155864 CDS NP_288882.1 15802855 957391 complement(3221356..3222042) 1 NC_002655.2 histidine transport system permease 3222042 hisQ 957391 hisQ Escherichia coli O157:H7 str. EDL933 histidine transport system permease NP_288882.1 3221356 R 155864 CDS NP_288883.1 15802856 959529 complement(3222132..3222914) 1 NC_002655.2 histidine-binding periplasmic protein of high-affinity histidine transport system 3222914 hisJ 959529 hisJ Escherichia coli O157:H7 str. EDL933 histidine-binding periplasmic protein of high-affinity histidine transport system NP_288883.1 3222132 R 155864 CDS NP_288884.1 15802857 959530 complement(3223135..3223917) 1 NC_002655.2 lysine-, arginine-, ornithine-binding periplasmic protein 3223917 argT 959530 argT Escherichia coli O157:H7 str. EDL933 lysine-, arginine-, ornithine-binding periplasmic protein NP_288884.1 3223135 R 155864 CDS NP_288885.1 15802858 959527 complement(3224183..3224752) 1 NC_002655.2 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 3224752 ubiX 959527 ubiX Escherichia coli O157:H7 str. EDL933 3-octaprenyl-4-hydroxybenzoate carboxy-lyase NP_288885.1 3224183 R 155864 CDS NP_288886.1 15802859 959520 complement(3224847..3226364) 1 NC_002655.2 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 3226364 purF 959520 purF Escherichia coli O157:H7 str. EDL933 amidophosphoribosyltransferase NP_288886.1 3224847 R 155864 CDS NP_288887.1 15802860 957414 complement(3226401..3226889) 1 NC_002655.2 membrane protein required for colicin V production; colicin V production protein 3226889 cvpA 957414 cvpA Escherichia coli O157:H7 str. EDL933 colicin V production protein NP_288887.1 3226401 R 155864 CDS NP_288888.1 15802861 959039 complement(3227331..3227993) 1 NC_002655.2 hypothetical protein 3227993 dedD 959039 dedD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288888.1 3227331 R 155864 CDS NP_288889.1 15802862 957529 complement(3227983..3229251) 1 NC_002655.2 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase 3229251 folC 957529 folC Escherichia coli O157:H7 str. EDL933 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase NP_288889.1 3227983 R 155864 CDS NP_288890.1 15802863 957472 complement(3229321..3230235) 1 NC_002655.2 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 3230235 accD 957472 accD Escherichia coli O157:H7 str. EDL933 acetyl-CoA carboxylase subunit beta NP_288890.1 3229321 R 155864 CDS NP_288891.1 15802864 957482 complement(3230391..3231050) 1 NC_002655.2 hypothetical protein 3231050 dedA 957482 dedA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288891.1 3230391 R 155864 CDS NP_288892.1 15802865 957710 complement(3231133..3231945) 1 NC_002655.2 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 3231945 truA 957710 truA Escherichia coli O157:H7 str. EDL933 tRNA pseudouridine synthase A NP_288892.1 3231133 R 155864 CDS NP_288893.1 15802866 957527 complement(3231945..3232958) 1 NC_002655.2 semialdehyde dehydrogenase 3232958 usg 957527 usg Escherichia coli O157:H7 str. EDL933 semialdehyde dehydrogenase NP_288893.1 3231945 R 155864 CDS NP_288894.1 15802867 957490 complement(3233024..3234160) 1 NC_002655.2 catalyzes the formation of 3-hydroxy-4-phospho-hydroxy-alpha-ketobutyrate from erythronate-4-phosphate; erythronate-4-phosphate dehydrogenase 3234160 pdxB 957490 pdxB Escherichia coli O157:H7 str. EDL933 erythronate-4-phosphate dehydrogenase NP_288894.1 3233024 R 155864 CDS NP_288895.1 15802868 957499 3234259..3235254 1 NC_002655.2 in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein; flagella biosynthesis regulator 3235254 flk 957499 flk Escherichia coli O157:H7 str. EDL933 flagella biosynthesis regulator NP_288895.1 3234259 D 155864 CDS NP_288896.1 15802869 958147 complement(3235251..3236429) 1 NC_002655.2 hypothetical protein 3236429 958147 Z3585 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288896.1 3235251 R 155864 CDS NP_288897.1 15802870 957480 complement(3236704..3237924) 1 NC_002655.2 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 3237924 fabB 957480 fabB Escherichia coli O157:H7 str. EDL933 3-oxoacyl-ACP synthase NP_288897.1 3236704 R 155864 CDS NP_288898.2 161367560 957500 3238083..3240089 1 NC_002655.2 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 3240089 mnmC 957500 mnmC Escherichia coli O157:H7 str. EDL933 5-methylaminomethyl-2-thiouridine methyltransferase NP_288898.2 3238083 D 155864 CDS NP_288899.1 15802872 957504 complement(3240210..3240488) 1 NC_002655.2 hypothetical protein 3240488 957504 Z3588 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288899.1 3240210 R 155864 CDS NP_288900.1 15802873 957505 complement(3240522..3241070) 1 NC_002655.2 transporting ATPase 3241070 957505 Z3589 Escherichia coli O157:H7 str. EDL933 transporting ATPase NP_288900.1 3240522 R 155864 CDS NP_288901.1 15802874 957506 complement(3241070..3241879) 1 NC_002655.2 hypothetical protein 3241879 yfcA 957506 yfcA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288901.1 3241070 R 155864 CDS NP_288902.1 15802875 961271 complement(3241879..3242703) 1 NC_002655.2 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase 3242703 mepA 961271 mepA Escherichia coli O157:H7 str. EDL933 penicillin-insensitive murein endopeptidase NP_288902.1 3241879 R 155864 CDS NP_288903.1 15802876 961327 complement(3242707..3243792) 1 NC_002655.2 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 3243792 aroC 961327 aroC Escherichia coli O157:H7 str. EDL933 chorismate synthase NP_288903.1 3242707 R 155864 CDS NP_288904.1 15802877 961293 complement(3243827..3245092) 1 NC_002655.2 involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 3245092 yfcB 961293 yfcB Escherichia coli O157:H7 str. EDL933 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase NP_288904.1 3243827 R 155864 CDS NP_288905.1 15802878 957513 3244925..3245476 1 NC_002655.2 hypothetical protein 3245476 957513 Z3594 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288905.1 3244925 D 155864 CDS NP_288906.1 15802879 957583 complement(3245647..3246489) 1 NC_002655.2 hypothetical protein 3246489 957583 Z3595 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288906.1 3245647 R 155864 CDS NP_288907.1 15802880 957046 complement(3246491..3247012) 1 NC_002655.2 minor fimbrial subunit 3247012 957046 Z3596 Escherichia coli O157:H7 str. EDL933 minor fimbrial subunit NP_288907.1 3246491 R 155864 CDS NP_288908.1 15802881 960278 complement(3247009..3247479) 1 NC_002655.2 minor fimbrial subunit 3247479 960278 Z3597 Escherichia coli O157:H7 str. EDL933 minor fimbrial subunit NP_288908.1 3247009 R 155864 CDS NP_288909.1 15802882 957516 complement(3247476..3248069) 1 NC_002655.2 minor fimbrial subunit 3248069 957516 Z3598 Escherichia coli O157:H7 str. EDL933 minor fimbrial subunit NP_288909.1 3247476 R 155864 CDS NP_288910.1 15802883 957517 complement(3247987..3248745) 1 NC_002655.2 fimbrial chaperone 3248745 yfcS 957517 yfcS Escherichia coli O157:H7 str. EDL933 fimbrial chaperone NP_288910.1 3247987 R 155864 CDS NP_288911.2 157267366 957523 complement(3248768..3251407) 1 NC_002655.2 fimbrial usher 3251407 957523 Z3600 Escherichia coli O157:H7 str. EDL933 fimbrial usher NP_288911.2 3248768 R 155864 CDS NP_288912.1 15802885 957669 complement(3251489..3252052) 1 NC_002655.2 major fimbrial subunit 3252052 957669 Z3601 Escherichia coli O157:H7 str. EDL933 major fimbrial subunit NP_288912.1 3251489 R 155864 CDS NP_288913.1 15802886 958720 complement(3252698..3253183) 1 NC_002655.2 phosphohistidine phosphatase 3253183 958720 Z3603 Escherichia coli O157:H7 str. EDL933 phosphohistidine phosphatase NP_288913.1 3252698 R 155864 CDS NP_288914.1 15802887 959521 complement(3253386..3255530) 1 NC_002655.2 multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate; multifunctional fatty acid oxidation complex subunit alpha 3255530 fadJ 959521 fadJ Escherichia coli O157:H7 str. EDL933 multifunctional fatty acid oxidation complex subunit alpha NP_288914.1 3253386 R 155864 CDS NP_288915.1 15802888 957526 complement(3255530..3256840) 1 NC_002655.2 FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth; 3-ketoacyl-CoA thiolase 3256840 fadI 957526 fadI Escherichia coli O157:H7 str. EDL933 3-ketoacyl-CoA thiolase NP_288915.1 3255530 R 155864 CDS NP_288916.1 15802889 958565 complement(3257020..3257328) 1 NC_002655.2 hypothetical protein 3257328 958565 Z3606 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288916.1 3257020 R 155864 CDS NP_288917.1 15802890 961192 3257670..3259016 1 NC_002655.2 long-chain fatty acid outer membrane transporter 3259016 fadL 961192 fadL Escherichia coli O157:H7 str. EDL933 long-chain fatty acid outer membrane transporter NP_288917.1 3257670 D 155864 CDS NP_288918.1 15802891 958349 3259381..3260412 1 NC_002655.2 hypothetical protein 3260412 958349 Z3609 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288918.1 3259381 D 155864 CDS NP_288919.1 15802892 957528 complement(3260807..3261562) 1 NC_002655.2 lipoprotein precursor 3261562 vacJ 957528 vacJ Escherichia coli O157:H7 str. EDL933 lipoprotein precursor NP_288919.1 3260807 R 155864 CDS NP_288920.1 15802893 957531 3261856..3262788 1 NC_002655.2 transport 3262788 yfdC 957531 yfdC Escherichia coli O157:H7 str. EDL933 transport NP_288920.1 3261856 D 155864 CDS NP_288921.1 15802894 960221 3263064..3264257 1 NC_002655.2 prophage integrase 3264257 intC 960221 intC Escherichia coli O157:H7 str. EDL933 prophage integrase NP_288921.1 3263064 D 155864 CDS NP_288922.1 15802895 957541 complement(3264432..3265568) 1 NC_002655.2 prophage DNA injection protein 3265568 957541 Z3614 Escherichia coli O157:H7 str. EDL933 prophage DNA injection protein NP_288922.1 3264432 R 155864 CDS NP_288923.1 15802896 960714 complement(3265578..3266258) 1 NC_002655.2 prophage DNA injection protein 3266258 960714 Z3615 Escherichia coli O157:H7 str. EDL933 prophage DNA injection protein NP_288923.1 3265578 R 155864 CDS NP_288924.1 15802897 960715 complement(3266245..3266712) 1 NC_002655.2 hypothetical protein 3266712 960715 Z3616 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288924.1 3266245 R 155864 CDS NP_288925.1 15802898 961333 complement(3266712..3267281) 1 NC_002655.2 No significant matches; hypothetical protein 3267281 961333 Z3617 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288925.1 3266712 R 155864 CDS NP_288926.1 15802899 957542 3267264..3267959 1 NC_002655.2 No significant matches; hypothetical protein 3267959 957542 Z3618 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288926.1 3267264 D 155864 CDS NP_288927.1 15802900 957545 complement(3268139..3268282) 1 NC_002655.2 No significant matches; hypothetical protein 3268282 957545 Z3619 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288927.1 3268139 R 155864 CDS NP_288928.1 15802901 961230 complement(3268629..3270041) 1 NC_002655.2 No significant matches; hypothetical protein 3270041 961230 Z3620 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288928.1 3268629 R 155864 CDS NP_288929.1 15802902 959294 complement(3270228..3270404) 1 NC_002655.2 No significant matches; hypothetical protein 3270404 959294 Z3621 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288929.1 3270228 R 155864 CDS NP_288930.1 15802903 957549 3270707..3271333 1 NC_002655.2 resolvase 3271333 957549 Z3622 Escherichia coli O157:H7 str. EDL933 resolvase NP_288930.1 3270707 D 155864 CDS NP_288931.1 15802904 958132 complement(3271931..3273178) 1 NC_002655.2 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease 3273178 lacY 958132 lacY Escherichia coli O157:H7 str. EDL933 galactoside permease NP_288931.1 3271931 R 155864 CDS NP_288932.1 15802905 956713 complement(3273250..3274167) 1 NC_002655.2 phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least; aminoimidazole riboside kinase 3274167 956713 Z3624 Escherichia coli O157:H7 str. EDL933 aminoimidazole riboside kinase NP_288932.1 3273250 R 155864 CDS NP_288933.1 15802906 957503 3274383..3275816 1 NC_002655.2 sucrose hydrolase 3275816 957503 Z3625 Escherichia coli O157:H7 str. EDL933 sucrose hydrolase NP_288933.1 3274383 D 155864 CDS NP_288934.1 15802907 957550 complement(3275824..3276819) 1 NC_002655.2 sucrose specific transcriptional regulator 3276819 957550 Z3626 Escherichia coli O157:H7 str. EDL933 sucrose specific transcriptional regulator NP_288934.1 3275824 R 155864 CDS NP_288935.1 15802908 957553 3277062..3277280 1 NC_002655.2 D-serine permease 3277280 957553 Z3627 Escherichia coli O157:H7 str. EDL933 D-serine permease NP_288935.1 3277062 D 155864 CDS NP_288936.1 15802909 957546 3277298..3278626 1 NC_002655.2 catalyzes the formation of pyruvate from serine; D-serine dehydratase 3278626 dsdA 957546 dsdA Escherichia coli O157:H7 str. EDL933 D-serine dehydratase NP_288936.1 3277298 D 155864 CDS NP_288937.1 15802910 957510 complement(3278734..3280272) 1 NC_002655.2 multidrug resistance protein Y 3280272 emrY 957510 emrY Escherichia coli O157:H7 str. EDL933 multidrug resistance protein Y NP_288937.1 3278734 R 155864 CDS NP_288938.1 15802911 959344 complement(3280272..3281435) 1 NC_002655.2 multidrug resistance protein K 3281435 emrK 959344 emrK Escherichia coli O157:H7 str. EDL933 multidrug resistance protein K NP_288938.1 3280272 R 155864 CDS NP_288939.1 15802912 958096 3281851..3282465 1 NC_002655.2 response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance; DNA-binding transcriptional activator EvgA 3282465 evgA 958096 evgA Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional activator EvgA NP_288939.1 3281851 D 155864 CDS NP_288940.1 15802913 957555 3282470..3286063 1 NC_002655.2 hybrid sensory histidine kinase in two-component regulatory system with EvgA 3286063 evgS 957555 evgS Escherichia coli O157:H7 str. EDL933 hybrid sensory histidine kinase in two-component regulatory system with EvgA NP_288940.1 3282470 D 155864 CDS NP_288941.1 15804989 959628 complement(join(3286119..3287087,3287084..3287299)) 1 NC_002655.2 hypothetical protein 3287299 yfdE 959628 yfdE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288941.1 3286119 R 155864 CDS NP_288942.1 15802914 958378 complement(3287334..3288278) 1 NC_002655.2 member of the AEC family of auxin efflux transporters; unknown function; transporter YfdV 3288278 958378 Z3635 Escherichia coli O157:H7 str. EDL933 transporter YfdV NP_288942.1 3287334 R 155864 CDS NP_288943.1 15802915 956741 complement(3288348..3290042) 1 NC_002655.2 catalyzes the formation of formyl-CoA from oxalyl-CoA; oxalyl-CoA decarboxylase 3290042 956741 Z3637 Escherichia coli O157:H7 str. EDL933 oxalyl-CoA decarboxylase NP_288943.1 3288348 R 155864 CDS NP_288944.1 15802916 957557 complement(3290096..3291346) 1 NC_002655.2 catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA; formyl-coenzyme A transferase 3291346 957557 Z3639 Escherichia coli O157:H7 str. EDL933 formyl-coenzyme A transferase NP_288944.1 3290096 R 155864 CDS NP_288945.1 15802917 957561 complement(3291859..3292494) 1 NC_002655.2 hypothetical protein 3292494 957561 Z3640 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288945.1 3291859 R 155864 CDS NP_288946.1 15802918 959420 3292790..3293065 1 NC_002655.2 hypothetical protein 3293065 959420 Z3641 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288946.1 3292790 D 155864 CDS NP_288947.1 15802919 957568 complement(3293142..3293384) 1 NC_002655.2 hypothetical protein 3293384 957568 Z3642 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288947.1 3293142 R 155864 CDS NP_288948.2 161367559 957573 3293738..3294658 1 NC_002655.2 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock; lipid A biosynthesis palmitoleoyl acyltransferase 3294658 ddg 957573 ddg Escherichia coli O157:H7 str. EDL933 lipid A biosynthesis palmitoleoyl acyltransferase NP_288948.2 3293738 D 155864 CDS NP_288949.1 15802921 957576 complement(3295150..3296388) 1 NC_002655.2 aminotransferase 3296388 957576 Z3644 Escherichia coli O157:H7 str. EDL933 aminotransferase NP_288949.1 3295150 R 155864 CDS NP_288950.1 15802922 957579 3296765..3298462 1 NC_002655.2 sensor protein 3298462 957579 Z3645 Escherichia coli O157:H7 str. EDL933 sensor protein NP_288950.1 3296765 D 155864 CDS NP_288951.1 15802923 957585 3298477..3299211 1 NC_002655.2 2-component transcriptional regulator 3299211 957585 Z3646 Escherichia coli O157:H7 str. EDL933 2-component transcriptional regulator NP_288951.1 3298477 D 155864 CDS NP_288952.1 15802924 957584 3299224..3300081 1 NC_002655.2 AraC family transcriptional regulator 3300081 957584 Z3647 Escherichia coli O157:H7 str. EDL933 AraC family transcriptional regulator NP_288952.1 3299224 D 155864 CDS NP_288953.1 15802925 957582 complement(3300084..3302579) 1 NC_002655.2 PTS system enzyme IIA component, enzyme I 3302579 957582 Z3648 Escherichia coli O157:H7 str. EDL933 PTS system enzyme IIA component, enzyme I NP_288953.1 3300084 R 155864 CDS NP_288954.1 15802926 957593 complement(3302604..3303641) 1 NC_002655.2 metalloprotein; exoaminopeptidase 3303641 957593 Z3649 Escherichia coli O157:H7 str. EDL933 exoaminopeptidase NP_288954.1 3302604 R 155864 CDS NP_288955.1 15802927 957594 complement(3303641..3304726) 1 NC_002655.2 Xaa-Pro aminopeptidase; limited methionine aminopeptidase; aminopeptidase 3304726 957594 Z3651 Escherichia coli O157:H7 str. EDL933 aminopeptidase NP_288955.1 3303641 R 155864 CDS NP_288956.1 15802928 957598 complement(3304741..3305988) 1 NC_002655.2 transporter 3305988 957598 Z3652 Escherichia coli O157:H7 str. EDL933 transporter NP_288956.1 3304741 R 155864 CDS NP_288957.1 15802929 959383 complement(3306010..3306336) 1 NC_002655.2 PTS system enzyme IIB component 3306336 959383 Z3653 Escherichia coli O157:H7 str. EDL933 PTS system enzyme IIB component NP_288957.1 3306010 R 155864 CDS NP_288958.1 15802930 961924 complement(3306555..3307520) 1 NC_002655.2 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; glucokinase 3307520 glk 961924 glk Escherichia coli O157:H7 str. EDL933 glucokinase NP_288958.1 3306555 R 155864 CDS NP_288959.1 15802931 959138 3307724..3308980 1 NC_002655.2 hypothetical protein 3308980 959138 Z3655 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288959.1 3307724 D 155864 CDS NP_288960.1 15802932 957602 3309095..3309421 1 NC_002655.2 hypothetical protein 3309421 957602 Z3656 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288960.1 3309095 D 155864 CDS NP_288962.1 15802934 960734 complement(3309561..3310799) 1 NC_002655.2 manganese transport protein MntH 3310799 960734 Z3658 Escherichia coli O157:H7 str. EDL933 manganese transport protein MntH NP_288962.1 3309561 R 155864 CDS NP_288963.1 15802935 960712 3311135..3312337 1 NC_002655.2 permease of transport system for 3 nucleosides 3312337 nupC 960712 nupC Escherichia coli O157:H7 str. EDL933 permease of transport system for 3 nucleosides NP_288963.1 3311135 D 155864 CDS NP_288964.1 15802936 960721 complement(3312387..3314615) 1 NC_002655.2 hypothetical protein 3314615 yfeA 960721 yfeA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288964.1 3312387 R 155864 CDS NP_288965.1 15802937 957610 3315080..3315439 1 NC_002655.2 hypothetical protein 3315439 yfeC 957610 yfeC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288965.1 3315080 D 155864 CDS NP_288966.1 15802938 956903 3315441..3315833 1 NC_002655.2 hypothetical protein 3315833 yfeD 956903 yfeD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288966.1 3315441 D 155864 CDS NP_288967.1 15802939 959536 complement(3315873..3317081) 1 NC_002655.2 virulence protein 3317081 959536 Z3664 Escherichia coli O157:H7 str. EDL933 virulence protein NP_288967.1 3315873 R 155864 CDS NP_288968.1 15802940 957612 complement(3317632..3319047) 1 NC_002655.2 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 3319047 gltX 957612 gltX Escherichia coli O157:H7 str. EDL933 glutamyl-tRNA synthetase NP_288968.1 3317632 R 155864 CDS NP_288969.1 15802941 958232 3319823..3320164 1 NC_002655.2 hypothetical protein 3320164 958232 Z3672 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288969.1 3319823 D 155864 CDS NP_288970.1 15805001 959627 complement(3320155..3321081) 1 NC_002655.2 transcriptional regulator 3321081 yfeR 959627 yfeR Escherichia coli O157:H7 str. EDL933 transcriptional regulator NP_288970.1 3320155 R 155864 CDS NP_288971.1 15802942 958427 3321171..3322169 1 NC_002655.2 cytochrome oxidase 3322169 yfeH 958427 yfeH Escherichia coli O157:H7 str. EDL933 cytochrome oxidase NP_288971.1 3321171 D 155864 CDS NP_288972.1 15802943 957623 complement(3322166..3322384) 1 NC_002655.2 No significant matches; hypothetical protein 3322384 957623 Z3676 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288972.1 3322166 R 155864 CDS NP_288973.1 15802944 957625 complement(3322386..3324401) 1 NC_002655.2 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 3324401 ligA 957625 ligA Escherichia coli O157:H7 str. EDL933 NAD-dependent DNA ligase LigA NP_288973.1 3322386 R 155864 CDS NP_288974.1 15802945 957627 complement(3324472..3325458) 1 NC_002655.2 interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA 3325458 zipA 957627 zipA Escherichia coli O157:H7 str. EDL933 cell division protein ZipA NP_288974.1 3324472 R 155864 CDS NP_288975.1 15802946 957629 3325688..3326449 1 NC_002655.2 role in sulfur assimilation; sulfate transport protein CysZ 3326449 cysZ 957629 cysZ Escherichia coli O157:H7 str. EDL933 sulfate transport protein CysZ NP_288975.1 3325688 D 155864 CDS NP_288976.1 15802947 957634 3326634..3327605 1 NC_002655.2 CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; cysteine synthase A 3327605 cysK 957634 cysK Escherichia coli O157:H7 str. EDL933 cysteine synthase A NP_288976.1 3326634 D 155864 CDS NP_288977.1 15802948 957637 3327989..3328246 1 NC_002655.2 PTS system phosphohistidinoprotein-hexose phosphotransferase Hpr 3328246 ptsH 957637 ptsH Escherichia coli O157:H7 str. EDL933 PTS system phosphohistidinoprotein-hexose phosphotransferase Hpr NP_288977.1 3327989 D 155864 CDS NP_288978.1 15802949 957641 3328291..3330018 1 NC_002655.2 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 3330018 ptsI 957641 ptsI Escherichia coli O157:H7 str. EDL933 phosphoenolpyruvate-protein phosphotransferase NP_288978.1 3328291 D 155864 CDS NP_288979.1 15802950 957642 3330059..3330568 1 NC_002655.2 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; PTS system glucose-specific transporter 3330568 crr 957642 crr Escherichia coli O157:H7 str. EDL933 PTS system glucose-specific transporter NP_288979.1 3330059 D 155864 CDS NP_288980.2 157267367 957643 complement(3330611..3331462) 1 NC_002655.2 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxal kinase 3331462 pdxK 957643 pdxK Escherichia coli O157:H7 str. EDL933 pyridoxal kinase NP_288980.2 3330611 R 155864 CDS NP_288981.1 15802952 958482 3331567..3331899 1 NC_002655.2 hypothetical protein 3331899 yfeK 958482 yfeK Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288981.1 3331567 D 155864 CDS NP_288982.1 15802953 958490 complement(3331937..3332848) 1 NC_002655.2 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide; cysteine synthase B 3332848 cysM 958490 cysM Escherichia coli O157:H7 str. EDL933 cysteine synthase B NP_288982.1 3331937 R 155864 CDS NP_288983.1 15802954 958489 complement(3332982..3334079) 1 NC_002655.2 sulfate/thiosulfate transporter subunit 3334079 cysA 958489 cysA Escherichia coli O157:H7 str. EDL933 sulfate/thiosulfate transporter subunit NP_288983.1 3332982 R 155864 CDS NP_288984.1 15804983 959635 complement(3334069..3334944) 1 NC_002655.2 Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import; sulfate/thiosulfate transporter permease subunit 3334944 cysW 959635 cysW Escherichia coli O157:H7 str. EDL933 sulfate/thiosulfate transporter permease subunit NP_288984.1 3334069 R 155864 CDS NP_288985.1 15802955 959620 complement(3334944..3335777) 1 NC_002655.2 sulfate/thiosulfate transporter subunit 3335777 cysU 959620 cysU Escherichia coli O157:H7 str. EDL933 sulfate/thiosulfate transporter subunit NP_288985.1 3334944 R 155864 CDS NP_288986.1 15802956 957646 complement(3335777..3336793) 1 NC_002655.2 thiosulfate transporter subunit 3336793 cysP 957646 cysP Escherichia coli O157:H7 str. EDL933 thiosulfate transporter subunit NP_288986.1 3335777 R 155864 CDS NP_288987.2 161367558 957651 complement(3336951..3337742) 1 NC_002655.2 short chain dehydrogenase 3337742 ucpA 957651 ucpA Escherichia coli O157:H7 str. EDL933 short chain dehydrogenase NP_288987.2 3336951 R 155864 CDS NP_288988.1 15802958 957653 complement(3337871..3338728) 1 NC_002655.2 hypothetical protein 3338728 yfeT 957653 yfeT Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288988.1 3337871 R 155864 CDS NP_288989.1 15802959 957656 3338892..3339788 1 NC_002655.2 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid 6-phosphate etherase 3339788 murQ 957656 murQ Escherichia coli O157:H7 str. EDL933 N-acetylmuramic acid 6-phosphate etherase NP_288989.1 3338892 D 155864 CDS NP_288990.1 15802960 957975 3339792..3341216 1 NC_002655.2 belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component; PTS system N-acetylmuramic acid transporter subunit IIBC 3341216 murP 957975 murP Escherichia coli O157:H7 str. EDL933 PTS system N-acetylmuramic acid transporter subunit IIBC NP_288990.1 3339792 D 155864 CDS NP_288991.2 161367557 958111 3341221..3342525 1 NC_002655.2 hypothetical protein 3342525 958111 Z3695 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288991.2 3341221 D 155864 CDS NP_288992.1 15802962 959394 complement(3342583..3343509) 1 NC_002655.2 hypothetical protein 3343509 959394 Z3696 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288992.1 3342583 R 155864 CDS NP_288993.1 15802963 957657 complement(3343578..3344153) 1 NC_002655.2 hypothetical protein 3344153 957657 Z3697 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288993.1 3343578 R 155864 CDS NP_288994.1 15802964 957663 complement(3344214..3344669) 1 NC_002655.2 hypothetical protein 3344669 957663 Z3698 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288994.1 3344214 R 155864 CDS NP_288995.2 161367556 957664 complement(3344650..3345075) 1 NC_002655.2 acetyltransferase 3345075 957664 Z3699 Escherichia coli O157:H7 str. EDL933 acetyltransferase NP_288995.2 3344650 R 155864 CDS NP_288996.1 15802966 957665 3345289..3346158 1 NC_002655.2 N-acetylmuramoyl-L-alanine amidase 3346158 amiA 957665 amiA Escherichia coli O157:H7 str. EDL933 N-acetylmuramoyl-L-alanine amidase NP_288996.1 3345289 D 155864 CDS NP_288997.1 15802967 957667 3346162..3347061 1 NC_002655.2 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 3347061 hemF 957667 hemF Escherichia coli O157:H7 str. EDL933 coproporphyrinogen III oxidase NP_288997.1 3346162 D 155864 CDS NP_288998.1 15802968 957125 complement(3347067..3348119) 1 NC_002655.2 activates the transcription of the ethanolamine utilization operon; transcriptional regulator EutR 3348119 yfeG 957125 yfeG Escherichia coli O157:H7 str. EDL933 transcriptional regulator EutR NP_288998.1 3347067 R 155864 CDS NP_288999.1 15802969 960434 complement(3348165..3348671) 1 NC_002655.2 hypothetical protein 3348671 960434 Z3703 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_288999.1 3348165 R 155864 CDS NP_289000.1 15802970 957668 complement(3348678..3349337) 1 NC_002655.2 hypothetical protein 3349337 957668 Z3704 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289000.1 3348678 R 155864 CDS NP_289001.1 15802971 957670 complement(3349347..3350234) 1 NC_002655.2 catalyzes the formation of acetaldehyde from ethanolamine; ethanolamine ammonia-lyase small subunit 3350234 eutC 957670 eutC Escherichia coli O157:H7 str. EDL933 ethanolamine ammonia-lyase small subunit NP_289001.1 3349347 R 155864 CDS NP_289002.1 15802972 957672 complement(3350255..3351616) 1 NC_002655.2 ethanolamine ammonia-lyase, heavy chain 3351616 eutB 957672 eutB Escherichia coli O157:H7 str. EDL933 ethanolamine ammonia-lyase, heavy chain NP_289002.1 3350255 R 155864 CDS NP_289003.1 15802973 957674 complement(3351628..3353031) 1 NC_002655.2 ethanolamine utilization protein EutA; reactivating factor for ethanolamine ammonia lyase 3353031 eutA 957674 eutA Escherichia coli O157:H7 str. EDL933 reactivating factor for ethanolamine ammonia lyase NP_289003.1 3351628 R 155864 CDS NP_289004.1 15802974 957676 complement(3353028..3354254) 1 NC_002655.2 ethanolamine transport protein 3354254 eutH 957676 eutH Escherichia coli O157:H7 str. EDL933 ethanolamine transport protein NP_289004.1 3353028 R 155864 CDS NP_289005.1 15802975 957680 complement(3354354..3355568) 1 NC_002655.2 iron-containing alcohol dehydrogenase 3355568 eutG 957680 eutG Escherichia coli O157:H7 str. EDL933 iron-containing alcohol dehydrogenase NP_289005.1 3354354 R 155864 CDS NP_289006.1 15802976 957682 complement(3355531..3356367) 1 NC_002655.2 hypothetical protein 3356367 eutJ 957682 eutJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289006.1 3355531 R 155864 CDS NP_289007.1 15802977 957684 complement(3356378..3357781) 1 NC_002655.2 ethanolamine utilization; acetaldehyde dehydrogenase 3357781 eutE 957684 eutE Escherichia coli O157:H7 str. EDL933 ethanolamine utilization; acetaldehyde dehydrogenase NP_289007.1 3356378 R 155864 CDS NP_289008.1 15802978 957691 complement(3357793..3358080) 1 NC_002655.2 detox protein 3358080 cchB 957691 cchB Escherichia coli O157:H7 str. EDL933 detox protein NP_289008.1 3357793 R 155864 CDS NP_289009.2 161367555 957693 complement(3358187..3358480) 1 NC_002655.2 detox protein 3358480 cchA 957693 cchA Escherichia coli O157:H7 str. EDL933 detox protein NP_289009.2 3358187 R 155864 CDS NP_289010.1 15802980 957696 complement(3358519..3359535) 1 NC_002655.2 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 3359535 eutD 957696 eutD Escherichia coli O157:H7 str. EDL933 phosphotransacetylase NP_289010.1 3358519 R 155864 CDS NP_289011.1 15802981 957698 complement(3359532..3360263) 1 NC_002655.2 hypothetical protein 3360263 957698 Z3715 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289011.1 3359532 R 155864 CDS NP_289012.1 15802982 957699 complement(3360260..3360961) 1 NC_002655.2 ethanolamine utilization protein EutQ 3360961 957699 Z3716 Escherichia coli O157:H7 str. EDL933 ethanolamine utilization protein EutQ NP_289012.1 3360260 R 155864 CDS NP_289013.1 15802983 957700 complement(3360936..3361415) 1 NC_002655.2 hypothetical protein 3361415 957700 Z3717 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289013.1 3360936 R 155864 CDS NP_289014.1 15802984 957702 complement(3361428..3361835) 1 NC_002655.2 hypothetical protein 3361835 957702 Z3718 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289014.1 3361428 R 155864 CDS NP_289015.1 15802985 957704 complement(3362056..3364335) 1 NC_002655.2 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme 3364335 957704 Z3719 Escherichia coli O157:H7 str. EDL933 malic enzyme NP_289015.1 3362056 R 155864 CDS NP_289016.1 15802986 957711 3364624..3365574 1 NC_002655.2 Maintains the balance of metabolites in the pentose-phosphate pathway; transaldolase A 3365574 talA 957711 talA Escherichia coli O157:H7 str. EDL933 transaldolase A NP_289016.1 3364624 D 155864 CDS NP_289017.1 15802987 957718 3365594..3367597 1 NC_002655.2 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 3367597 tktB 957718 tktB Escherichia coli O157:H7 str. EDL933 transketolase NP_289017.1 3365594 D 155864 CDS NP_289018.1 15802988 957721 complement(3367692..3368735) 1 NC_002655.2 hypothetical protein 3368735 957721 Z3722 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289018.1 3367692 R 155864 CDS NP_289019.1 15802989 957723 complement(3368861..3369436) 1 NC_002655.2 hypothetical protein 3369436 yffH 957723 yffH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289019.1 3368861 R 155864 CDS NP_289020.1 15802990 960795 complement(3369504..3371483) 1 NC_002655.2 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); oxidoreductase Fe-S binding subunit 3371483 yffG 960795 yffG Escherichia coli O157:H7 str. EDL933 oxidoreductase Fe-S binding subunit NP_289020.1 3369504 R 155864 CDS NP_289021.1 15802991 960722 3371689..3373389 1 NC_002655.2 nitrate/nitrite sensor protein NarQ 3373389 narQ 960722 narQ Escherichia coli O157:H7 str. EDL933 nitrate/nitrite sensor protein NarQ NP_289021.1 3371689 D 155864 CDS NP_289022.1 15802992 957725 3373553..3376666 1 NC_002655.2 aminoglycoside/multidrug efflux system 3376666 acrD 957725 acrD Escherichia coli O157:H7 str. EDL933 aminoglycoside/multidrug efflux system NP_289022.1 3373553 D 155864 CDS NP_289023.1 15802993 957727 3377205..3377561 1 NC_002655.2 hypothetical protein 3377561 yffB 957727 yffB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289023.1 3377205 D 155864 CDS NP_289024.1 15802994 957867 3377565..3378692 1 NC_002655.2 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 3378692 dapE 957867 dapE Escherichia coli O157:H7 str. EDL933 succinyl-diaminopimelate desuccinylase NP_289024.1 3377565 D 155864 CDS NP_289025.1 15802995 961036 3378720..3378920 1 NC_002655.2 hypothetical protein 3378920 961036 Z3731 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289025.1 3378720 D 155864 CDS NP_289026.2 161367554 957734 complement(3379001..3379699) 1 NC_002655.2 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase 3379699 ypfH 957734 ypfH Escherichia coli O157:H7 str. EDL933 esterase NP_289026.2 3379001 R 155864 CDS NP_289027.1 15802997 957735 complement(3379773..3381788) 1 NC_002655.2 hypothetical protein 3381788 ypfI 957735 ypfI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289027.1 3379773 R 155864 CDS NP_289028.1 15802998 957737 complement(3381803..3382666) 1 NC_002655.2 hypothetical protein 3382666 957737 Z3734 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289028.1 3381803 R 155864 CDS NP_289029.1 15802999 957467 complement(3382834..3383547) 1 NC_002655.2 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 3383547 purC 957467 purC Escherichia coli O157:H7 str. EDL933 phosphoribosylaminoimidazole-succinocarboxamide synthase NP_289029.1 3382834 R 155864 CDS NP_289030.2 157267368 959543 complement(3383760..3384797) 1 NC_002655.2 lipoprotein 3384797 nlpB 959543 nlpB Escherichia coli O157:H7 str. EDL933 lipoprotein NP_289030.2 3383760 R 155864 CDS NP_289031.1 15803001 957738 complement(3384811..3385689) 1 NC_002655.2 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 3385689 dapA 957738 dapA Escherichia coli O157:H7 str. EDL933 dihydrodipicolinate synthase NP_289031.1 3384811 R 155864 CDS NP_289032.2 161367553 957739 3385835..3386407 1 NC_002655.2 negative transcriptional regulator of the gcvTHP operon; glycine cleavage system transcriptional repressor 3386407 gcvR 957739 gcvR Escherichia coli O157:H7 str. EDL933 glycine cleavage system transcriptional repressor NP_289032.2 3385835 D 155864 CDS NP_289033.1 15803003 957792 3386407..3386877 1 NC_002655.2 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 3386877 bcp 957792 bcp Escherichia coli O157:H7 str. EDL933 thioredoxin-dependent thiol peroxidase NP_289033.1 3386407 D 155864 CDS NP_289034.1 15803004 957091 3387091..3387747 1 NC_002655.2 hydrogenase 4 Fe-S subunit 3387747 hyfA 957091 hyfA Escherichia coli O157:H7 str. EDL933 hydrogenase 4 Fe-S subunit NP_289034.1 3387091 D 155864 CDS NP_289035.1 15803005 957742 3387747..3389765 1 NC_002655.2 Catalyzes the transfer of electrons from NADH to ubiquinone; hydrogenase 4 subunit B 3389765 hyfB 957742 hyfB Escherichia coli O157:H7 str. EDL933 hydrogenase 4 subunit B NP_289035.1 3387747 D 155864 CDS NP_289036.1 15803006 957743 3389755..3390723 1 NC_002655.2 hydrogenase 4 membrane subunit 3390723 hyfC 957743 hyfC Escherichia coli O157:H7 str. EDL933 hydrogenase 4 membrane subunit NP_289036.1 3389755 D 155864 CDS NP_289037.1 15803007 956883 3390740..3392179 1 NC_002655.2 hydrogenase 4 subunit D 3392179 hyfD 956883 hyfD Escherichia coli O157:H7 str. EDL933 hydrogenase 4 subunit D NP_289037.1 3390740 D 155864 CDS NP_289038.1 15803008 957815 3392191..3392841 1 NC_002655.2 interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide; hydrogenase 4 membrane subunit 3392841 hyfE 957815 hyfE Escherichia coli O157:H7 str. EDL933 hydrogenase 4 membrane subunit NP_289038.1 3392191 D 155864 CDS NP_289039.1 15803009 956967 3392846..3394426 1 NC_002655.2 Catalyzes the transfer of electrons from NADH to ubiquinone; hydrogenase 4 subunit F 3394426 hyfF 956967 hyfF Escherichia coli O157:H7 str. EDL933 hydrogenase 4 subunit F NP_289039.1 3392846 D 155864 CDS NP_289040.1 15803010 959545 3394416..3396131 1 NC_002655.2 hydrogenase 4 subunit 3396131 hyfG 959545 hyfG Escherichia coli O157:H7 str. EDL933 hydrogenase 4 subunit NP_289040.1 3394416 D 155864 CDS NP_289041.1 15803011 957744 3396141..3396686 1 NC_002655.2 probable electron transfer protein for hydrogenase 4; hydrogenase 4 is believed to be silent in E. coli under conditions tested so far; hydrogenase 4 subunit H 3396686 hyfH 957744 hyfH Escherichia coli O157:H7 str. EDL933 hydrogenase 4 subunit H NP_289041.1 3396141 D 155864 CDS NP_289042.1 15803012 959571 3396683..3397441 1 NC_002655.2 hydrogenase 4 Fe-S subunit 3397441 hyfI 959571 hyfI Escherichia coli O157:H7 str. EDL933 hydrogenase 4 Fe-S subunit NP_289042.1 3396683 D 155864 CDS NP_289043.1 15803013 961407 3397371..3397847 1 NC_002655.2 protein processing element 3397847 961407 Z3750 Escherichia coli O157:H7 str. EDL933 protein processing element NP_289043.1 3397371 D 155864 CDS NP_289044.1 15803014 958161 3397877..3399916 1 NC_002655.2 2-component regulator 3399916 hyfR 958161 hyfR Escherichia coli O157:H7 str. EDL933 2-component regulator NP_289044.1 3397877 D 155864 CDS NP_289045.1 15803015 961354 3399913..3400761 1 NC_002655.2 inner membrane protein presumed to act as a formate transporter; member of the hyf operon; formate transporter 3400761 focB 961354 focB Escherichia coli O157:H7 str. EDL933 formate transporter NP_289045.1 3399913 D 155864 CDS NP_289046.1 15803016 957749 complement(3400799..3401860) 1 NC_002655.2 permease 3401860 perM 957749 perM Escherichia coli O157:H7 str. EDL933 permease NP_289046.1 3400799 R 155864 CDS NP_289047.1 15803017 957750 3402073..3403536 1 NC_002655.2 hypothetical protein 3403536 957750 Z3757 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289047.1 3402073 D 155864 CDS NP_289048.1 15803018 957753 3403557..3403916 1 NC_002655.2 oxidoreductase 3403916 957753 Z3758 Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_289048.1 3403557 D 155864 CDS NP_289049.1 15803019 957755 complement(3404054..3404800) 1 NC_002655.2 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; DNA replication initiation factor 3404800 957755 Z3759 Escherichia coli O157:H7 str. EDL933 DNA replication initiation factor NP_289049.1 3404054 R 155864 CDS NP_289050.1 15803020 957761 complement(3404850..3406139) 1 NC_002655.2 uracil transporter 3406139 uraA 957761 uraA Escherichia coli O157:H7 str. EDL933 uracil transporter NP_289050.1 3404850 R 155864 CDS NP_289051.2 161367552 961291 complement(3406225..3406851) 1 NC_002655.2 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 3406851 upp 961291 upp Escherichia coli O157:H7 str. EDL933 uracil phosphoribosyltransferase NP_289051.2 3406225 R 155864 CDS NP_289052.1 15803022 961316 3407176..3408213 1 NC_002655.2 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 3408213 purM 961316 purM Escherichia coli O157:H7 str. EDL933 phosphoribosylaminoimidazole synthetase NP_289052.1 3407176 D 155864 CDS NP_289053.1 15803023 961321 3408213..3408851 1 NC_002655.2 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 3408851 purN 961321 purN Escherichia coli O157:H7 str. EDL933 phosphoribosylglycinamide formyltransferase NP_289053.1 3408213 D 155864 CDS NP_289054.1 15803024 957762 3409022..3411088 1 NC_002655.2 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 3411088 ppk 957762 ppk Escherichia coli O157:H7 str. EDL933 polyphosphate kinase NP_289054.1 3409022 D 155864 CDS NP_289055.1 15803025 957770 3411093..3412634 1 NC_002655.2 exopolyphosphatase 3412634 ppx 957770 ppx Escherichia coli O157:H7 str. EDL933 exopolyphosphatase NP_289055.1 3411093 D 155864 CDS NP_289056.1 15803026 958361 complement(3412673..3414916) 1 NC_002655.2 cytochrome C biogenesis protein 3414916 958361 Z3766 Escherichia coli O157:H7 str. EDL933 cytochrome C biogenesis protein NP_289056.1 3412673 R 155864 CDS NP_289057.1 15803027 958386 complement(3415098..3415250) 1 NC_002655.2 No significant matches; hypothetical protein 3415250 958386 Z3767 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289057.1 3415098 R 155864 CDS NP_289058.1 15803028 957900 3415268..3415459 1 NC_002655.2 hypothetical protein 3415459 957900 Z3768 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289058.1 3415268 D 155864 CDS NP_289059.1 15803029 959398 3415770..3416288 1 NC_002655.2 outer membrane lipoprotein 3416288 959398 Z3769 Escherichia coli O157:H7 str. EDL933 outer membrane lipoprotein NP_289059.1 3415770 D 155864 CDS NP_289060.1 15803030 957775 3416304..3416843 1 NC_002655.2 hypothetical protein 3416843 957775 Z3770 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289060.1 3416304 D 155864 CDS NP_289061.1 15803031 957778 complement(3416936..3418513) 1 NC_002655.2 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 3418513 guaA 957778 guaA Escherichia coli O157:H7 str. EDL933 GMP synthase NP_289061.1 3416936 R 155864 CDS NP_289062.1 15803032 957789 complement(3418582..3420048) 1 NC_002655.2 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 3420048 guaB 957789 guaB Escherichia coli O157:H7 str. EDL933 inosine 5'-monophosphate dehydrogenase NP_289062.1 3418582 R 155864 CDS NP_289063.1 15803033 959509 3420210..3421580 1 NC_002655.2 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 3421580 xseA 959509 xseA Escherichia coli O157:H7 str. EDL933 exodeoxyribonuclease VII large subunit NP_289063.1 3420210 D 155864 CDS NP_289064.2 161367551 959526 complement(3421861..3423333) 1 NC_002655.2 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 3423333 engA 959526 engA Escherichia coli O157:H7 str. EDL933 GTP-binding protein EngA NP_289064.2 3421861 R 155864 CDS NP_289065.1 15803035 961353 complement(3423451..3424629) 1 NC_002655.2 with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis; outer membrane protein assembly complex subunit YfgL 3424629 961353 Z3775 Escherichia coli O157:H7 str. EDL933 outer membrane protein assembly complex subunit YfgL NP_289065.1 3423451 R 155864 CDS NP_289066.1 15803036 961303 complement(3424640..3425260) 1 NC_002655.2 hypothetical protein 3425260 961303 Z3776 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289066.1 3424640 R 155864 CDS NP_289067.1 15803037 957790 complement(3425278..3426552) 1 NC_002655.2 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 3426552 hisS 957790 hisS Escherichia coli O157:H7 str. EDL933 histidyl-tRNA synthetase NP_289067.1 3425278 R 155864 CDS NP_289068.1 15803038 957794 complement(3426663..3427781) 1 NC_002655.2 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 3427781 ispG 957794 ispG Escherichia coli O157:H7 str. EDL933 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase NP_289068.1 3426663 R 155864 CDS NP_289069.1 15803039 957798 complement(3427808..3428821) 1 NC_002655.2 cytoskeletal protein RodZ 3428821 yfgA 957798 yfgA Escherichia coli O157:H7 str. EDL933 cytoskeletal protein RodZ NP_289069.1 3427808 R 155864 CDS NP_289070.1 15803040 957803 complement(3429106..3430260) 1 NC_002655.2 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 3430260 yfgB 957803 yfgB Escherichia coli O157:H7 str. EDL933 ribosomal RNA large subunit methyltransferase N NP_289070.1 3429106 R 155864 CDS NP_289071.1 15803041 957806 complement(3430410..3430841) 1 NC_002655.2 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 3430841 ndk 957806 ndk Escherichia coli O157:H7 str. EDL933 nucleoside diphosphate kinase NP_289071.1 3430410 R 155864 CDS NP_289072.1 15803042 960730 complement(3430982..3431560) 1 NC_002655.2 No significant matches; hypothetical protein 3431560 960730 Z3782 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289072.1 3430982 R 155864 CDS NP_289073.1 15803043 957807 complement(3431836..3432657) 1 NC_002655.2 dimethyl sulfoxide reductase subunit C 3432657 957807 Z3783 Escherichia coli O157:H7 str. EDL933 dimethyl sulfoxide reductase subunit C NP_289073.1 3431836 R 155864 CDS NP_289074.1 15803044 957809 complement(3432650..3433087) 1 NC_002655.2 dimethyl sulfoxide reductase subunit B 3433087 957809 Z3784 Escherichia coli O157:H7 str. EDL933 dimethyl sulfoxide reductase subunit B NP_289074.1 3432650 R 155864 CDS NP_289075.1 15803045 957810 complement(3433276..3435657) 1 NC_002655.2 dimethyl sulfoxide reductase subunit A 3435657 957810 Z3785 Escherichia coli O157:H7 str. EDL933 dimethyl sulfoxide reductase subunit A NP_289075.1 3433276 R 155864 CDS NP_289076.2 161367550 957817 complement(3435821..3438133) 1 NC_002655.2 penicillin-insensitive transglycosylase/transpeptidase; penicillin-binding protein 1C 3438133 pbpC 957817 pbpC Escherichia coli O157:H7 str. EDL933 penicillin-binding protein 1C NP_289076.2 3435821 R 155864 CDS NP_289077.1 15803047 957818 complement(3438134..3443095) 1 NC_002655.2 hypothetical protein 3443095 957818 Z3787 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289077.1 3438134 R 155864 CDS NP_289078.2 161367549 957822 3443302..3444147 1 NC_002655.2 catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds; 3-mercaptopyruvate sulfurtransferase 3444147 sseA 957822 sseA Escherichia coli O157:H7 str. EDL933 3-mercaptopyruvate sulfurtransferase NP_289078.2 3443302 D 155864 CDS NP_289079.1 15803049 957827 complement(3444647..3445456) 1 NC_002655.2 enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I; enhanced serine sensitivity protein SseB 3445456 sseB 957827 sseB Escherichia coli O157:H7 str. EDL933 enhanced serine sensitivity protein SseB NP_289079.1 3444647 R 155864 CDS NP_289080.2 161367548 959184 complement(3445567..3446850) 1 NC_002655.2 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase 3446850 pepB 959184 pepB Escherichia coli O157:H7 str. EDL933 aminopeptidase NP_289080.2 3445567 R 155864 CDS NP_289081.1 15803051 959402 complement(3447028..3447228) 1 NC_002655.2 hypothetical protein 3447228 yfhJ 959402 yfhJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289081.1 3447028 R 155864 CDS NP_289082.1 15803052 957832 complement(3447240..3447575) 1 NC_002655.2 [2FE-2S] ferredoxin, electron carrer protein 3447575 fdx 957832 fdx Escherichia coli O157:H7 str. EDL933 [2FE-2S] ferredoxin, electron carrer protein NP_289082.1 3447240 R 155864 CDS NP_289083.1 15803053 957772 complement(3447577..3449427) 1 NC_002655.2 involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA 3449427 hscA 957772 hscA Escherichia coli O157:H7 str. EDL933 chaperone protein HscA NP_289083.1 3447577 R 155864 CDS NP_289084.1 15803054 957840 complement(3449444..3449959) 1 NC_002655.2 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB 3449959 hscB 957840 hscB Escherichia coli O157:H7 str. EDL933 co-chaperone HscB NP_289084.1 3449444 R 155864 CDS NP_289085.1 15803055 957129 complement(3450055..3450378) 1 NC_002655.2 forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein; iron-sulfur cluster assembly protein 3450378 iscA 957129 iscA Escherichia coli O157:H7 str. EDL933 iron-sulfur cluster assembly protein NP_289085.1 3450055 R 155864 CDS NP_289086.1 15803056 957837 complement(3450395..3450781) 1 NC_002655.2 scaffold protein 3450781 957837 Z3796 Escherichia coli O157:H7 str. EDL933 scaffold protein NP_289086.1 3450395 R 155864 CDS NP_289087.1 15803057 957843 complement(3450809..3452047) 1 NC_002655.2 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase 3452047 yfhO 957843 yfhO Escherichia coli O157:H7 str. EDL933 cysteine desulfurase NP_289087.1 3450809 R 155864 CDS NP_289088.1 15803058 957689 complement(3452135..3452623) 1 NC_002655.2 regulates the expression of the iscRSUA operon; DNA-binding transcriptional regulator IscR 3452623 957689 Z3798 Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator IscR NP_289088.1 3452135 R 155864 CDS NP_289089.1 15803059 957846 complement(3452924..3453661) 1 NC_002655.2 ATP synthase subunit beta 3453661 957846 Z3799 Escherichia coli O157:H7 str. EDL933 ATP synthase subunit beta NP_289089.1 3452924 R 155864 CDS NP_289090.1 15803060 957848 3454701..3455582 1 NC_002655.2 hydrolase 3455582 957848 Z3802 Escherichia coli O157:H7 str. EDL933 hydrolase NP_289090.1 3454701 D 155864 CDS NP_289091.2 161367547 958388 3455773..3457053 1 NC_002655.2 stationary phase inducible protein CsiE 3457053 csiE 958388 csiE Escherichia coli O157:H7 str. EDL933 stationary phase inducible protein CsiE NP_289091.2 3455773 D 155864 CDS NP_289092.1 15803062 958412 complement(3457045..3458184) 1 NC_002655.2 transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; 3-phenylpropionic acid transporter 3458184 hcaT 958412 hcaT Escherichia coli O157:H7 str. EDL933 3-phenylpropionic acid transporter NP_289092.1 3457045 R 155864 CDS NP_289093.1 15803063 957329 complement(3458345..3459235) 1 NC_002655.2 activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional regulator HcaR 3459235 hcaR 957329 hcaR Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator HcaR NP_289093.1 3458345 R 155864 CDS NP_289094.1 15803064 957853 3459371..3460732 1 NC_002655.2 large terminal subunit of phenylpropionate dioxygenase 3460732 hcaA1 957853 hcaA1 Escherichia coli O157:H7 str. EDL933 large terminal subunit of phenylpropionate dioxygenase NP_289094.1 3459371 D 155864 CDS NP_289095.1 15803065 957854 3460729..3461247 1 NC_002655.2 3-phenylpropionate dioxygenase subunit beta 3461247 hcaA2 957854 hcaA2 Escherichia coli O157:H7 str. EDL933 3-phenylpropionate dioxygenase subunit beta NP_289095.1 3460729 D 155864 CDS NP_289096.1 15803066 957855 3461247..3461567 1 NC_002655.2 3-phenylpropionate dioxygenase ferredoxin subunit 3461567 hcaC 957855 hcaC Escherichia coli O157:H7 str. EDL933 3-phenylpropionate dioxygenase ferredoxin subunit NP_289096.1 3461247 D 155864 CDS NP_289097.1 15803067 960726 3461564..3462376 1 NC_002655.2 Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate; 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase 3462376 hcaB 960726 hcaB Escherichia coli O157:H7 str. EDL933 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase NP_289097.1 3461564 D 155864 CDS NP_289098.1 15803068 958539 3462386..3463588 1 NC_002655.2 phenylpropionate dioxygenase ferredoxin reductase subunit 3463588 hcaD 958539 hcaD Escherichia coli O157:H7 str. EDL933 phenylpropionate dioxygenase ferredoxin reductase subunit NP_289098.1 3462386 D 155864 CDS NP_289099.1 15803069 957862 3463640..3464107 1 NC_002655.2 hypothetical protein 3464107 yphA 957862 yphA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289099.1 3463640 D 155864 CDS NP_289100.1 15803070 957869 complement(3464155..3465027) 1 NC_002655.2 hypothetical protein 3465027 yphB 957869 yphB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289100.1 3464155 R 155864 CDS NP_289101.1 15805002 959623 complement(3465039..3466133) 1 NC_002655.2 Zn-dependent dehydrogenase 3466133 yphC 959623 yphC Escherichia coli O157:H7 str. EDL933 Zn-dependent dehydrogenase NP_289101.1 3465039 R 155864 CDS NP_289102.1 15803071 957871 complement(3466166..3467164) 1 NC_002655.2 transport system permease 3467164 yphD 957871 yphD Escherichia coli O157:H7 str. EDL933 transport system permease NP_289102.1 3466166 R 155864 CDS NP_289103.1 15803072 961180 complement(3467189..3468700) 1 NC_002655.2 ABC transporter ATP-binding protein 3468700 yphE 961180 yphE Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_289103.1 3467189 R 155864 CDS NP_289104.1 15803073 956939 complement(3468723..3469706) 1 NC_002655.2 LACI-type transcriptional regulator 3469706 yphF 956939 yphF Escherichia coli O157:H7 str. EDL933 LACI-type transcriptional regulator NP_289104.1 3468723 R 155864 CDS NP_289105.1 15803074 957875 complement(3469803..3473177) 1 NC_002655.2 hypothetical protein 3473177 yphG 957875 yphG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289105.1 3469803 R 155864 CDS NP_289106.1 15803075 957880 3473196..3474395 1 NC_002655.2 NAGC-like transcriptional regulator 3474395 yphH 957880 yphH Escherichia coli O157:H7 str. EDL933 NAGC-like transcriptional regulator NP_289106.1 3473196 D 155864 CDS NP_289107.1 15803076 957380 complement(3474458..3475711) 1 NC_002655.2 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 3475711 glyA 957380 glyA Escherichia coli O157:H7 str. EDL933 serine hydroxymethyltransferase NP_289107.1 3474458 R 155864 CDS NP_289108.1 15803077 959263 3476039..3477229 1 NC_002655.2 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine; nitric oxide dioxygenase 3477229 hmpA 959263 hmpA Escherichia coli O157:H7 str. EDL933 nitric oxide dioxygenase NP_289108.1 3476039 D 155864 CDS NP_289109.1 15803078 961286 complement(3477274..3477612) 1 NC_002655.2 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; nitrogen regulatory protein P-II 1 3477612 glnB 961286 glnB Escherichia coli O157:H7 str. EDL933 nitrogen regulatory protein P-II 1 NP_289109.1 3477274 R 155864 CDS NP_289110.1 15803079 957883 complement(3477673..3479007) 1 NC_002655.2 2-component transcriptional regulator 3479007 yfhA 957883 yfhA Escherichia coli O157:H7 str. EDL933 2-component transcriptional regulator NP_289110.1 3477673 R 155864 CDS NP_289111.1 15803080 957887 complement(3478997..3479710) 1 NC_002655.2 hypothetical protein 3479710 yfhG 957887 yfhG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289111.1 3478997 R 155864 CDS NP_289112.1 15803081 957893 complement(3479875..3481365) 1 NC_002655.2 2-component sensor protein 3481365 yfhK 957893 yfhK Escherichia coli O157:H7 str. EDL933 2-component sensor protein NP_289112.1 3479875 R 155864 CDS NP_289113.1 15803082 957901 complement(3481878..3485765) 1 NC_002655.2 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase 3485765 purL 957901 purL Escherichia coli O157:H7 str. EDL933 phosphoribosylformylglycinamidine synthase NP_289113.1 3481878 R 155864 CDS NP_289114.1 15803083 958091 3486160..3487578 1 NC_002655.2 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function; transglycosylase 3487578 yfhD 958091 yfhD Escherichia coli O157:H7 str. EDL933 transglycosylase NP_289114.1 3486160 D 155864 CDS NP_289115.1 15803084 958078 complement(3487575..3488111) 1 NC_002655.2 tRNA-specific adenosine deaminase 3488111 yfhC 958078 yfhC Escherichia coli O157:H7 str. EDL933 tRNA-specific adenosine deaminase NP_289115.1 3487575 R 155864 CDS NP_289116.2 161367546 957606 complement(3488136..3488771) 1 NC_002655.2 hypothetical protein 3488771 yfhB 957606 yfhB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289116.2 3488136 R 155864 CDS NP_289117.2 161367545 957907 3488980..3489828 1 NC_002655.2 DNA-binding transcriptional regulator 3489828 yfhH 957907 yfhH Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator NP_289117.2 3488980 D 155864 CDS NP_289118.1 15803087 957913 3489884..3490144 1 NC_002655.2 hypothetical protein 3490144 yfhL 957913 yfhL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289118.1 3489884 D 155864 CDS NP_289119.1 15803088 957917 complement(3490416..3490568) 1 NC_002655.2 No significant matches; hypothetical protein 3490568 957917 Z3843 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289119.1 3490416 R 155864 CDS NP_289120.1 15803089 957918 complement(3490841..3491221) 1 NC_002655.2 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 3491221 acpS 957918 acpS Escherichia coli O157:H7 str. EDL933 4'-phosphopantetheinyl transferase NP_289120.1 3490841 R 155864 CDS NP_289121.1 15803090 957924 complement(3491221..3491952) 1 NC_002655.2 involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase 3491952 pdxJ 957924 pdxJ Escherichia coli O157:H7 str. EDL933 pyridoxine 5'-phosphate synthase NP_289121.1 3491221 R 155864 CDS NP_289122.1 15803091 957925 complement(3491964..3492692) 1 NC_002655.2 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 3492692 recO 957925 recO Escherichia coli O157:H7 str. EDL933 DNA repair protein RecO NP_289122.1 3491964 R 155864 CDS NP_289123.1 15803092 957928 complement(3492704..3493609) 1 NC_002655.2 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 3493609 era 957928 era Escherichia coli O157:H7 str. EDL933 GTP-binding protein Era NP_289123.1 3492704 R 155864 CDS NP_289124.1 15803093 957930 complement(3493606..3494286) 1 NC_002655.2 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 3494286 rnc 957930 rnc Escherichia coli O157:H7 str. EDL933 ribonuclease III NP_289124.1 3493606 R 155864 CDS NP_289125.1 15803094 957939 3494344..3494508 1 NC_002655.2 No significant matches; hypothetical protein 3494508 957939 Z3849 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289125.1 3494344 D 155864 CDS NP_289126.1 15803095 957941 complement(3494559..3495533) 1 NC_002655.2 catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins; signal peptidase I 3495533 lepB 957941 lepB Escherichia coli O157:H7 str. EDL933 signal peptidase I NP_289126.1 3494559 R 155864 CDS NP_289127.1 15803096 957944 complement(3495549..3497348) 1 NC_002655.2 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 3497348 lepA 957944 lepA Escherichia coli O157:H7 str. EDL933 GTP-binding protein LepA NP_289127.1 3495549 R 155864 CDS NP_289128.1 15803097 957946 complement(3497546..3498025) 1 NC_002655.2 involved in the reduction of the SoxR iron-sulfur cluster; SoxR reducing system protein RseC 3498025 rseC 957946 rseC Escherichia coli O157:H7 str. EDL933 SoxR reducing system protein RseC NP_289128.1 3497546 R 155864 CDS NP_289129.1 15803098 957951 complement(3498022..3498978) 1 NC_002655.2 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; periplasmic negative regulator of sigmaE 3498978 rseB 957951 rseB Escherichia coli O157:H7 str. EDL933 periplasmic negative regulator of sigmaE NP_289129.1 3498022 R 155864 CDS NP_289130.1 15803099 957954 complement(3498978..3499616) 1 NC_002655.2 anti-RNA polymerase sigma factor SigE 3499616 rseA 957954 rseA Escherichia coli O157:H7 str. EDL933 anti-RNA polymerase sigma factor SigE NP_289130.1 3498978 R 155864 CDS NP_289131.1 15803100 957965 complement(3499649..3500224) 1 NC_002655.2 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE 3500224 rpoE 957965 rpoE Escherichia coli O157:H7 str. EDL933 RNA polymerase sigma factor RpoE NP_289131.1 3499649 R 155864 CDS NP_289132.1 15803101 957968 3500632..3502254 1 NC_002655.2 catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 3502254 nadB 957968 nadB Escherichia coli O157:H7 str. EDL933 L-aspartate oxidase NP_289132.1 3500632 D 155864 CDS NP_289133.1 15803102 959275 complement(3502239..3503096) 1 NC_002655.2 hypothetical protein 3503096 yfiC 959275 yfiC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289133.1 3502239 R 155864 CDS NP_289134.1 15803103 959293 3503108..3504442 1 NC_002655.2 facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 3504442 srmB 959293 srmB Escherichia coli O157:H7 str. EDL933 ATP-dependent RNA helicase SrmB NP_289134.1 3503108 D 155864 CDS NP_289135.1 15803104 956956 complement(3504475..3505401) 1 NC_002655.2 LysR family transcriptional regulator 3505401 yfiE 956956 yfiE Escherichia coli O157:H7 str. EDL933 LysR family transcriptional regulator NP_289135.1 3504475 R 155864 CDS NP_289136.1 15803105 959378 3505459..3506046 1 NC_002655.2 neutral amino-acid efflux protein 3506046 yfiK 959378 yfiK Escherichia coli O157:H7 str. EDL933 neutral amino-acid efflux protein NP_289136.1 3505459 D 155864 CDS NP_289137.1 15803106 957971 complement(3506102..3506485) 1 NC_002655.2 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA 3506485 yfiD 957971 yfiD Escherichia coli O157:H7 str. EDL933 autonomous glycyl radical cofactor GrcA NP_289137.1 3506102 R 155864 CDS NP_289138.1 15803107 957972 3506790..3507479 1 NC_002655.2 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 3507479 ung 957972 ung Escherichia coli O157:H7 str. EDL933 uracil-DNA glycosylase NP_289138.1 3506790 D 155864 CDS NP_289139.1 15803108 957978 complement(3507527..3508564) 1 NC_002655.2 methyltransferase 3508564 yfiF 957978 yfiF Escherichia coli O157:H7 str. EDL933 methyltransferase NP_289139.1 3507527 R 155864 CDS NP_289140.1 15803109 957979 complement(3508554..3508757) 1 NC_002655.2 No significant matches; hypothetical protein 3508757 957979 Z3866 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289140.1 3508554 R 155864 CDS NP_289141.1 15803110 957981 3508771..3509190 1 NC_002655.2 thioredoxin 3509190 trxC 957981 trxC Escherichia coli O157:H7 str. EDL933 thioredoxin NP_289141.1 3508771 D 155864 CDS NP_289142.1 15803111 957983 3509235..3509957 1 NC_002655.2 hypothetical protein 3509957 yfiP 957983 yfiP Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289142.1 3509235 D 155864 CDS NP_289143.1 15803112 957987 3509989..3512649 1 NC_002655.2 hypothetical protein 3512649 yfiQ 957987 yfiQ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289143.1 3509989 D 155864 CDS NP_289144.1 15803113 957988 3512760..3514118 1 NC_002655.2 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 3514118 pssA 957988 pssA Escherichia coli O157:H7 str. EDL933 phosphatidylserine synthase NP_289144.1 3512760 D 155864 CDS NP_289145.1 15803114 960432 3514215..3514487 1 NC_002655.2 hypothetical protein 3514487 yfiM 960432 yfiM Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289145.1 3514215 D 155864 CDS NP_289146.1 15803115 959504 complement(3514484..3515782) 1 NC_002655.2 alpha-ketoglutarate transporter 3515782 kgtP 959504 kgtP Escherichia coli O157:H7 str. EDL933 alpha-ketoglutarate transporter NP_289146.1 3514484 R 155864 CDS NP_289147.1 15803116 958006 complement(3521568..3524153) 1 NC_002655.2 protein disaggregation chaperone 3524153 clpB 958006 clpB Escherichia coli O157:H7 str. EDL933 protein disaggregation chaperone NP_289147.1 3521568 R 155864 CDS NP_289148.1 15803117 958009 complement(3524271..3525002) 1 NC_002655.2 hypothetical protein 3525002 yfiH 958009 yfiH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289148.1 3524271 R 155864 CDS NP_289149.1 15803118 960934 complement(3524999..3525979) 1 NC_002655.2 responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D 3525979 rluD 960934 rluD Escherichia coli O157:H7 str. EDL933 23S rRNA pseudouridine synthase D NP_289149.1 3524999 R 155864 CDS NP_289150.1 15803119 960368 3526114..3526851 1 NC_002655.2 with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline; outer membrane protein assembly complex subunit YfiO 3526851 960368 Z3889 Escherichia coli O157:H7 str. EDL933 outer membrane protein assembly complex subunit YfiO NP_289150.1 3526114 D 155864 CDS NP_289151.1 15803120 956875 3527122..3527463 1 NC_002655.2 associated with 30S ribosomal subunit; interferes with translation elongation; translation inhibitor protein RaiA 3527463 yfiA 956875 yfiA Escherichia coli O157:H7 str. EDL933 translation inhibitor protein RaiA NP_289151.1 3527122 D 155864 CDS NP_289152.1 15803121 958015 3527713..3528873 1 NC_002655.2 catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; bifunctional chorismate mutase/prephenate dehydratase 3528873 pheA 958015 pheA Escherichia coli O157:H7 str. EDL933 bifunctional chorismate mutase/prephenate dehydratase NP_289152.1 3527713 D 155864 CDS NP_289153.1 15803122 958018 complement(3528916..3530037) 1 NC_002655.2 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase 3530037 tyrA 958018 tyrA Escherichia coli O157:H7 str. EDL933 bifunctional chorismate mutase/prephenate dehydrogenase NP_289153.1 3528916 R 155864 CDS NP_289154.1 15803123 958019 complement(3530048..3531118) 1 NC_002655.2 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 3531118 aroF 958019 aroF Escherichia coli O157:H7 str. EDL933 phospho-2-dehydro-3-deoxyheptonate aldolase NP_289154.1 3530048 R 155864 CDS NP_289155.1 15803124 957905 3531289..3531693 1 NC_002655.2 hypothetical protein 3531693 yfiL 957905 yfiL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289155.1 3531289 D 155864 CDS NP_289156.1 15803125 956960 3531843..3532361 1 NC_002655.2 hypothetical protein 3532361 956960 Z3897 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289156.1 3531843 D 155864 CDS NP_289157.1 15803126 958022 3532351..3533577 1 NC_002655.2 hypothetical protein 3533577 yfiN 958022 yfiN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289157.1 3532351 D 155864 CDS NP_289158.1 15803127 958027 3533593..3534075 1 NC_002655.2 outer membrane lipoprotein 3534075 yfiB 958027 yfiB Escherichia coli O157:H7 str. EDL933 outer membrane lipoprotein NP_289158.1 3533593 D 155864 CDS NP_289159.1 15803128 958030 complement(3534152..3534499) 1 NC_002655.2 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 3534499 rplS 958030 rplS Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L19 NP_289159.1 3534152 R 155864 CDS NP_289160.1 15803129 958031 complement(3534541..3535308) 1 NC_002655.2 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 3535308 trmD 958031 trmD Escherichia coli O157:H7 str. EDL933 tRNA (guanine-N(1)-)-methyltransferase NP_289160.1 3534541 R 155864 CDS NP_289161.2 161367544 958032 complement(3535339..3535887) 1 NC_002655.2 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 3535887 rimM 958032 rimM Escherichia coli O157:H7 str. EDL933 16S rRNA-processing protein RimM NP_289161.2 3535339 R 155864 CDS NP_289162.1 15803131 956739 complement(3535906..3536154) 1 NC_002655.2 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 3536154 rpsP 956739 rpsP Escherichia coli O157:H7 str. EDL933 30S ribosomal protein S16 NP_289162.1 3535906 R 155864 CDS NP_289163.1 15803132 959351 complement(3536291..3537652) 1 NC_002655.2 with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins; signal recognition particle protein 3537652 ffh 959351 ffh Escherichia coli O157:H7 str. EDL933 signal recognition particle protein NP_289163.1 3536291 R 155864 CDS NP_289164.1 15803133 958735 3537744..3538610 1 NC_002655.2 hypothetical protein 3538610 958735 Z3905 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289164.1 3537744 D 155864 CDS NP_289165.1 15804990 959626 3538656..3539918 1 NC_002655.2 hypothetical protein 3539918 yfjD 959626 yfjD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289165.1 3538656 D 155864 CDS NP_289166.1 15803134 957103 complement(3539973..3540566) 1 NC_002655.2 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 3540566 grpE 957103 grpE Escherichia coli O157:H7 str. EDL933 heat shock protein GrpE NP_289166.1 3539973 R 155864 CDS NP_289167.1 15803135 958034 3540689..3541567 1 NC_002655.2 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 3541567 ppnK 958034 ppnK Escherichia coli O157:H7 str. EDL933 inorganic polyphosphate/ATP-NAD kinase NP_289167.1 3540689 D 155864 CDS NP_289168.1 15803136 958036 3541653..3543314 1 NC_002655.2 recombination and repair protein 3543314 recN 958036 recN Escherichia coli O157:H7 str. EDL933 recombination and repair protein NP_289168.1 3541653 D 155864 CDS NP_289169.1 15803137 957902 3543652..3543804 1 NC_002655.2 small membrane protein A 3543804 smpA 957902 smpA Escherichia coli O157:H7 str. EDL933 small membrane protein A NP_289169.1 3543652 D 155864 CDS NP_289170.2 161367543 958546 complement(3543866..3544156) 1 NC_002655.2 hypothetical protein 3544156 958546 Z3911 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289170.2 3543866 R 155864 CDS NP_289171.1 15803139 958037 complement(3544146..3544622) 1 NC_002655.2 hypothetical protein 3544622 958037 Z3912 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289171.1 3544146 R 155864 CDS NP_289172.1 15803140 958044 3544754..3545236 1 NC_002655.2 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 3545236 smpB 958044 smpB Escherichia coli O157:H7 str. EDL933 SsrA-binding protein NP_289172.1 3544754 D 155864 CDS NP_289173.1 15803141 956667 3546082..3546330 1 NC_002655.2 hypothetical protein 3546330 956667 Z3916 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289173.1 3546082 D 155864 CDS NP_289174.1 15803142 958049 complement(3546530..3546616) 1 NC_002655.2 No significant matches; hypothetical protein 3546616 958049 Z3917 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289174.1 3546530 R 155864 CDS NP_289175.1 15803143 958050 complement(3546832..3547422) 1 NC_002655.2 chaperone protein 3547422 958050 Z3918 Escherichia coli O157:H7 str. EDL933 chaperone protein NP_289175.1 3546832 R 155864 CDS NP_289176.1 15803144 958051 3547605..3548255 1 NC_002655.2 hypothetical protein 3548255 958051 Z3919 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289176.1 3547605 D 155864 CDS NP_289177.1 15803145 958058 3548334..3549392 1 NC_002655.2 hypothetical protein 3549392 958058 Z3920 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289177.1 3548334 D 155864 CDS NP_289178.1 15803146 958060 complement(3549522..3550001) 1 NC_002655.2 hypothetical protein 3550001 958060 Z3921 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289178.1 3549522 R 155864 CDS NP_289179.1 15803147 958064 3550280..3550606 1 NC_002655.2 transposase 3550606 958064 Z3922 Escherichia coli O157:H7 str. EDL933 transposase NP_289179.1 3550280 D 155864 CDS NP_289180.1 15803148 958065 3550606..3550812 1 NC_002655.2 hypothetical protein 3550812 958065 Z3923 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289180.1 3550606 D 155864 CDS NP_289181.1 15803149 957279 3550847..3551065 1 NC_002655.2 transposase 3551065 957279 Z3924 Escherichia coli O157:H7 str. EDL933 transposase NP_289181.1 3550847 D 155864 CDS NP_289182.1 15803150 959339 3551085..3551495 1 NC_002655.2 transposase 3551495 959339 Z3925 Escherichia coli O157:H7 str. EDL933 transposase NP_289182.1 3551085 D 155864 CDS NP_289183.1 15803151 957556 complement(3551577..3552050) 1 NC_002655.2 hypothetical protein 3552050 957556 Z3926 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289183.1 3551577 R 155864 CDS NP_289184.1 15803152 958212 complement(3552256..3553428) 1 NC_002655.2 hypothetical protein 3553428 958212 Z3927 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289184.1 3552256 R 155864 CDS NP_289185.1 15803153 958067 complement(3553836..3553946) 1 NC_002655.2 No significant matches; hypothetical protein 3553946 958067 Z3929 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289185.1 3553836 R 155864 CDS NP_289186.1 15803154 958068 complement(3554089..3554847) 1 NC_002655.2 hypothetical protein 3554847 958068 Z3931 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289186.1 3554089 R 155864 CDS NP_289187.1 15803155 958069 complement(3555085..3555708) 1 NC_002655.2 antiterminator of prophage CP-933Y 3555708 958069 Z3932 Escherichia coli O157:H7 str. EDL933 antiterminator of prophage CP-933Y NP_289187.1 3555085 R 155864 CDS NP_289188.1 15803156 958070 complement(3555705..3556370) 1 NC_002655.2 hypothetical protein 3556370 958070 Z3933 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289188.1 3555705 R 155864 CDS NP_289189.1 15803157 958071 complement(3556367..3556567) 1 NC_002655.2 hypothetical protein 3556567 958071 Z3934 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289189.1 3556367 R 155864 CDS NP_289190.1 15803158 958687 complement(3556953..3557558) 1 NC_002655.2 hypothetical protein 3557558 958687 Z3935 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289190.1 3556953 R 155864 CDS NP_289191.1 15803159 961454 3557855..3558610 1 NC_002655.2 IS30 transposase 3558610 tra8_3 961454 tra8_3 Escherichia coli O157:H7 str. EDL933 IS30 transposase NP_289191.1 3557855 D 155864 CDS NP_289192.1 15803160 958072 3558670..3558948 1 NC_002655.2 No significant matches; hypothetical protein 3558948 958072 Z3937 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289192.1 3558670 D 155864 CDS NP_289193.1 15803161 958077 3559119..3559238 1 NC_002655.2 No significant matches; hypothetical protein 3559238 958077 Z3938 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289193.1 3559119 D 155864 CDS NP_289194.1 15803162 958079 complement(3559338..3560246) 1 NC_002655.2 No significant matches; hypothetical protein 3560246 958079 Z3939 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289194.1 3559338 R 155864 CDS NP_289195.1 15803163 958092 complement(3560643..3561113) 1 NC_002655.2 No significant matches; hypothetical protein 3561113 958092 Z3940 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289195.1 3560643 R 155864 CDS NP_289196.1 15803164 957282 complement(3561154..3561375) 1 NC_002655.2 No significant matches; hypothetical protein 3561375 957282 Z3941 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289196.1 3561154 R 155864 CDS NP_289197.1 15803165 958080 complement(3561775..3563187) 1 NC_002655.2 No significant matches; hypothetical protein 3563187 958080 Z3942 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289197.1 3561775 R 155864 CDS NP_289198.1 15803166 956686 complement(3563184..3564509) 1 NC_002655.2 No significant matches; hypothetical protein 3564509 956686 Z3943 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289198.1 3563184 R 155864 CDS NP_289199.1 15803167 959361 complement(3564664..3565707) 1 NC_002655.2 hypothetical protein 3565707 959361 Z3945 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289199.1 3564664 R 155864 CDS NP_289200.1 15803168 956685 complement(3566030..3566236) 1 NC_002655.2 DNA binding protein 3566236 956685 Z3946 Escherichia coli O157:H7 str. EDL933 DNA binding protein NP_289200.1 3566030 R 155864 CDS NP_289201.1 15803169 960720 complement(3566336..3567187) 1 NC_002655.2 No significant matches; hypothetical protein 3567187 960720 Z3947 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289201.1 3566336 R 155864 CDS NP_289202.1 15803170 959506 complement(3567614..3572200) 1 NC_002655.2 ABC transporter ATP-binding protein 3572200 ypjA 959506 ypjA Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_289202.1 3567614 R 155864 CDS NP_289203.1 15803171 959496 complement(3572539..3572682) 1 NC_002655.2 hypothetical protein 3572682 959496 Z3949 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289203.1 3572539 R 155864 CDS NP_289204.1 15803172 958085 complement(3573136..3574485) 1 NC_002655.2 hypothetical protein 3574485 958085 Z3950 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289204.1 3573136 R 155864 CDS NP_289205.1 15803173 961325 complement(3574993..3575145) 1 NC_002655.2 No significant matches; hypothetical protein 3575145 961325 Z3951 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289205.1 3574993 R 155864 CDS NP_289206.1 15803174 958089 3575873..3577111 1 NC_002655.2 hypothetical protein 3577111 958089 Z3954 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289206.1 3575873 D 155864 CDS NP_289207.1 15803175 958090 3577118..3578125 1 NC_002655.2 hypothetical protein 3578125 958090 Z3955 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289207.1 3577118 D 155864 CDS NP_289208.2 161367542 958097 3578462..3579439 1 NC_002655.2 in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution; hypothetical protein 3579439 958097 Z3956 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289208.2 3578462 D 155864 CDS NP_289209.1 15803177 958098 3579393..3580727 1 NC_002655.2 catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate; hydroxyglutarate oxidase 3580727 ygaF 958098 ygaF Escherichia coli O157:H7 str. EDL933 hydroxyglutarate oxidase NP_289209.1 3579393 D 155864 CDS NP_289210.1 15803178 958101 3580750..3582198 1 NC_002655.2 catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; succinate-semialdehyde dehydrogenase I 3582198 gabD 958101 gabD Escherichia coli O157:H7 str. EDL933 succinate-semialdehyde dehydrogenase I NP_289210.1 3580750 D 155864 CDS NP_289211.1 15803179 958102 3582212..3583492 1 NC_002655.2 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 3583492 gabT 958102 gabT Escherichia coli O157:H7 str. EDL933 4-aminobutyrate aminotransferase NP_289211.1 3582212 D 155864 CDS NP_289212.1 15803180 958106 3583730..3585130 1 NC_002655.2 gamma-aminobutyrate transporter 3585130 gabP 958106 gabP Escherichia coli O157:H7 str. EDL933 gamma-aminobutyrate transporter NP_289212.1 3583730 D 155864 CDS NP_289214.2 161367541 960476 3585151..3585813 1 NC_002655.2 regulator of gab gene expression; DNA-binding transcriptional regulator CsiR 3585813 ygaE 960476 ygaE Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator CsiR NP_289214.2 3585151 D 155864 CDS NP_289215.1 15803183 958075 complement(3585814..3586263) 1 NC_002655.2 LysM domain/BON superfamily protein 3586263 ygaU 958075 ygaU Escherichia coli O157:H7 str. EDL933 LysM domain/BON superfamily protein NP_289215.1 3585814 R 155864 CDS NP_289216.1 15803184 958066 complement(3586347..3586505) 1 NC_002655.2 hypothetical protein 3586505 958066 Z3965 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289216.1 3586347 R 155864 CDS NP_289217.1 15803185 958107 3586688..3586987 1 NC_002655.2 hypothetical protein 3586987 958107 Z3966 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289217.1 3586688 D 155864 CDS NP_289218.1 15803186 958109 3586997..3587515 1 NC_002655.2 hypothetical protein 3587515 ygaP 958109 ygaP Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289218.1 3586997 D 155864 CDS NP_289219.1 15803187 958518 complement(3587568..3587972) 1 NC_002655.2 DNA binding protein 3587972 stpA 958518 stpA Escherichia coli O157:H7 str. EDL933 DNA binding protein NP_289219.1 3587568 R 155864 CDS NP_289220.1 15803188 959318 3588640..3589089 1 NC_002655.2 hypothetical protein 3589089 959318 Z3970 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289220.1 3588640 D 155864 CDS NP_289221.1 15803189 956958 complement(3589126..3589470) 1 NC_002655.2 hypothetical protein 3589470 ygaC 956958 ygaC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289221.1 3589126 R 155864 CDS NP_289222.1 15803190 958113 3589610..3589951 1 NC_002655.2 hypothetical protein 3589951 ygaM 958113 ygaM Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289222.1 3589610 D 155864 CDS NP_289223.1 15803191 958118 complement(3590101..3591435) 1 NC_002655.2 hypothetical protein 3591435 958118 Z3973 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289223.1 3590101 R 155864 CDS NP_289224.1 15803192 958441 3591523..3591954 1 NC_002655.2 hypothetical protein 3591954 958441 Z3974 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289224.1 3591523 D 155864 CDS NP_289225.1 15803193 958447 3592163..3592408 1 NC_002655.2 glutaredoxin-like protein 3592408 nrdH 958447 nrdH Escherichia coli O157:H7 str. EDL933 glutaredoxin-like protein NP_289225.1 3592163 D 155864 CDS NP_289226.1 15803194 957903 3592405..3592815 1 NC_002655.2 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 3592815 nrdI 957903 nrdI Escherichia coli O157:H7 str. EDL933 ribonucleotide reductase stimulatory protein NP_289226.1 3592405 D 155864 CDS NP_289227.1 15803195 958123 3592788..3594932 1 NC_002655.2 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 3594932 nrdE 958123 nrdE Escherichia coli O157:H7 str. EDL933 ribonucleotide-diphosphate reductase subunit alpha NP_289227.1 3592788 D 155864 CDS NP_289228.1 15803196 958124 3594942..3595901 1 NC_002655.2 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 3595901 nrdF 958124 nrdF Escherichia coli O157:H7 str. EDL933 ribonucleotide-diphosphate reductase subunit beta NP_289228.1 3594942 D 155864 CDS NP_289229.1 15803197 958127 3596257..3597459 1 NC_002655.2 with ProWX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter ATP-binding subunit 3597459 proV 958127 proV Escherichia coli O157:H7 str. EDL933 glycine betaine transporter ATP-binding subunit NP_289229.1 3596257 D 155864 CDS NP_289230.1 15803198 958130 3597452..3598516 1 NC_002655.2 with ProVX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter membrane protein 3598516 proW 958130 proW Escherichia coli O157:H7 str. EDL933 glycine betaine transporter membrane protein NP_289230.1 3597452 D 155864 CDS NP_289231.1 15803199 958117 3598573..3599565 1 NC_002655.2 with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine; glycine betaine transporter periplasmic subunit 3599565 proX 958117 proX Escherichia coli O157:H7 str. EDL933 glycine betaine transporter periplasmic subunit NP_289231.1 3598573 D 155864 CDS NP_289232.1 15803200 958108 3599757..3600941 1 NC_002655.2 transporter 3600941 958108 Z3982 Escherichia coli O157:H7 str. EDL933 transporter NP_289232.1 3599757 D 155864 CDS NP_289233.1 15803201 958105 3601065..3601802 1 NC_002655.2 hypothetical protein 3601802 958105 Z3983 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289233.1 3601065 D 155864 CDS NP_289234.1 15803202 958131 3601792..3602127 1 NC_002655.2 hypothetical protein 3602127 ygaH 958131 ygaH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289234.1 3601792 D 155864 CDS NP_289235.1 15803203 958137 3602218..3602748 1 NC_002655.2 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB; transcriptional repressor MprA 3602748 emrR 958137 emrR Escherichia coli O157:H7 str. EDL933 transcriptional repressor MprA NP_289235.1 3602218 D 155864 CDS NP_289236.1 15803204 958138 3602875..3604047 1 NC_002655.2 multidrug resistance secretion protein 3604047 emrA 958138 emrA Escherichia coli O157:H7 str. EDL933 multidrug resistance secretion protein NP_289236.1 3602875 D 155864 CDS NP_289237.1 15803205 957369 3604064..3605602 1 NC_002655.2 multidrug resistance protein B 3605602 emrB 957369 emrB Escherichia coli O157:H7 str. EDL933 multidrug resistance protein B NP_289237.1 3604064 D 155864 CDS NP_289238.1 15803206 960942 complement(3605666..3606181) 1 NC_002655.2 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 3606181 ygaG 960942 ygaG Escherichia coli O157:H7 str. EDL933 S-ribosylhomocysteinase NP_289238.1 3605666 R 155864 CDS NP_289239.1 15803207 959286 complement(3606331..3607887) 1 NC_002655.2 involved in the first step of glutathione biosynthesis; glutamate--cysteine ligase 3607887 gshA 959286 gshA Escherichia coli O157:H7 str. EDL933 glutamate--cysteine ligase NP_289239.1 3606331 R 155864 CDS NP_289240.1 15803208 957957 complement(3607960..3608388) 1 NC_002655.2 hypothetical protein 3608388 957957 Z3990 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289240.1 3607960 R 155864 CDS NP_289241.1 15803209 958139 complement(3608385..3608951) 1 NC_002655.2 YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent; fructose-1-phosphatase 3608951 yqaB 958139 yqaB Escherichia coli O157:H7 str. EDL933 fructose-1-phosphatase NP_289241.1 3608385 R 155864 CDS NP_289242.1 15803210 956962 complement(3610180..3610365) 1 NC_002655.2 affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator 3610365 csrA 956962 csrA Escherichia coli O157:H7 str. EDL933 carbon storage regulator NP_289242.1 3610180 R 155864 CDS NP_289243.1 15803211 958243 complement(3610595..3613231) 1 NC_002655.2 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 3613231 alaS 958243 alaS Escherichia coli O157:H7 str. EDL933 alanyl-tRNA synthetase NP_289243.1 3610595 R 155864 CDS NP_289244.1 15803212 958152 3612917..3613318 1 NC_002655.2 No significant matches; hypothetical protein 3613318 958152 Z4000 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289244.1 3612917 D 155864 CDS NP_289245.1 15803213 956712 complement(3613359..3613859) 1 NC_002655.2 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 3613859 recX 956712 recX Escherichia coli O157:H7 str. EDL933 recombination regulator RecX NP_289245.1 3613359 R 155864 CDS NP_289246.1 15803214 958481 complement(3613927..3614988) 1 NC_002655.2 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 3614988 recA 958481 recA Escherichia coli O157:H7 str. EDL933 recombinase A NP_289246.1 3613927 R 155864 CDS NP_289247.1 15803215 958154 complement(3615068..3615565) 1 NC_002655.2 competence damage-inducible protein A 3615565 ygaD 958154 ygaD Escherichia coli O157:H7 str. EDL933 competence damage-inducible protein A NP_289247.1 3615068 R 155864 CDS NP_289248.1 15803216 958155 complement(3615710..3616795) 1 NC_002655.2 membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan; murein hydrolase B 3616795 mltB 958155 mltB Escherichia coli O157:H7 str. EDL933 murein hydrolase B NP_289248.1 3615710 R 155864 CDS NP_289249.1 15803217 958148 3617050..3617445 1 NC_002655.2 PTS system, glucitol/sorbitol-specific IIC component, one of two; frag 3617445 srlA_1 958148 srlA_1 Escherichia coli O157:H7 str. EDL933 PTS system, glucitol/sorbitol-specific IIC component, one of two; frag NP_289249.1 3617050 D 155864 CDS NP_289250.1 15803218 958136 3617478..3617612 1 NC_002655.2 PTS system, glucitol/sorbitol-specific IIC component, one of two; frag 3617612 srlA_2 958136 srlA_2 Escherichia coli O157:H7 str. EDL933 PTS system, glucitol/sorbitol-specific IIC component, one of two; frag NP_289250.1 3617478 D 155864 CDS NP_289251.1 15803219 958164 3617609..3617815 1 NC_002655.2 PTS system, glucitol/sorbitol-specific IIB component and second of two IIC components; frag 3617815 srlE_1 958164 srlE_1 Escherichia coli O157:H7 str. EDL933 PTS system, glucitol/sorbitol-specific IIB component and second of two IIC components; frag NP_289251.1 3617609 D 155864 CDS NP_289252.1 15803220 958167 3617920..3618570 1 NC_002655.2 PTS system, glucitol/sorbitol-specific IIB component and second of two IIC components; frag 3618570 srlE_2 958167 srlE_2 Escherichia coli O157:H7 str. EDL933 PTS system, glucitol/sorbitol-specific IIB component and second of two IIC components; frag NP_289252.1 3617920 D 155864 CDS NP_289253.1 15803221 958241 3618581..3618952 1 NC_002655.2 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucitol/sorbitol-specific transporter subunit IIA 3618952 srlB 958241 srlB Escherichia coli O157:H7 str. EDL933 PTS system glucitol/sorbitol-specific transporter subunit IIA NP_289253.1 3618581 D 155864 CDS NP_289254.1 15803222 957080 3618956..3619735 1 NC_002655.2 catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate; sorbitol-6-phosphate dehydrogenase 3619735 srlD 957080 srlD Escherichia coli O157:H7 str. EDL933 sorbitol-6-phosphate dehydrogenase NP_289254.1 3618956 D 155864 CDS NP_289255.1 15803223 958170 3619841..3620200 1 NC_002655.2 regulator for glucitol utilization; DNA-binding transcriptional activator GutM 3620200 gutM 958170 gutM Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional activator GutM NP_289255.1 3619841 D 155864 CDS NP_289256.1 15803224 958179 3620352..3621041 1 NC_002655.2 regulates genes involved in glucitol utilization; DNA-binding transcriptional repressor SrlR 3621041 srlR 958179 srlR Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional repressor SrlR NP_289256.1 3620352 D 155864 CDS NP_289257.2 161367540 958166 3621034..3621999 1 NC_002655.2 catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate; D-arabinose 5-phosphate isomerase 3621999 gutQ 958166 gutQ Escherichia coli O157:H7 str. EDL933 D-arabinose 5-phosphate isomerase NP_289257.2 3621034 D 155864 CDS NP_289258.2 161367539 958171 complement(3621996..3623510) 1 NC_002655.2 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon; anaerobic nitric oxide reductase transcriptional regulator 3623510 ygaA 958171 ygaA Escherichia coli O157:H7 str. EDL933 anaerobic nitric oxide reductase transcriptional regulator NP_289258.2 3621996 R 155864 CDS NP_289259.1 15803227 958174 3623697..3624932 1 NC_002655.2 detoxifies nitric oxide using NADH; anaerobic nitric oxide reductase flavorubredoxin 3624932 958174 Z4018 Escherichia coli O157:H7 str. EDL933 anaerobic nitric oxide reductase flavorubredoxin NP_289259.1 3623697 D 155864 CDS NP_289260.1 15803228 961331 3624929..3626062 1 NC_002655.2 catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase; nitric oxide reductase 3626062 ygbD 961331 ygbD Escherichia coli O157:H7 str. EDL933 nitric oxide reductase NP_289260.1 3624929 D 155864 CDS NP_289261.1 15803229 957086 complement(3626190..3628442) 1 NC_002655.2 transcriptional regulatory protein 3628442 hypF 957086 hypF Escherichia coli O157:H7 str. EDL933 transcriptional regulatory protein NP_289261.1 3626190 R 155864 CDS NP_289262.1 15803230 960982 complement(3628595..3629122) 1 NC_002655.2 involved in electron transport from formate to hydrogen; electron transport protein HydN 3629122 hydN 960982 hydN Escherichia coli O157:H7 str. EDL933 electron transport protein HydN NP_289262.1 3628595 R 155864 CDS NP_289263.1 15803231 958175 complement(3629271..3630284) 1 NC_002655.2 ascBF operon repressor 3630284 ascG 958175 ascG Escherichia coli O157:H7 str. EDL933 ascBF operon repressor NP_289263.1 3629271 R 155864 CDS NP_289264.1 15803232 958177 3630541..3631998 1 NC_002655.2 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system cellobiose/arbutin/salicin-specific transporter subunit IIBC 3631998 ascF 958177 ascF Escherichia coli O157:H7 str. EDL933 PTS system cellobiose/arbutin/salicin-specific transporter subunit IIBC NP_289264.1 3630541 D 155864 CDS NP_289265.1 15803233 960884 3632007..3633431 1 NC_002655.2 cryptic 6-phospho-beta-glucosidase 3633431 ascB 960884 ascB Escherichia coli O157:H7 str. EDL933 cryptic 6-phospho-beta-glucosidase NP_289265.1 3632007 D 155864 CDS NP_289266.1 15803234 959495 complement(3633555..3634025) 1 NC_002655.2 involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; hydrogenase 3 maturation protease 3634025 hycI 959495 hycI Escherichia coli O157:H7 str. EDL933 hydrogenase 3 maturation protease NP_289266.1 3633555 R 155864 CDS NP_289267.1 15803235 961285 complement(3634018..3634428) 1 NC_002655.2 processing of large subunit (HycE) of hydrogenase 3 (part of the FHL complex) 3634428 hycH 961285 hycH Escherichia coli O157:H7 str. EDL933 processing of large subunit (HycE) of hydrogenase 3 (part of the FHL complex) NP_289267.1 3634018 R 155864 CDS NP_289268.1 15803236 961295 complement(3634425..3635192) 1 NC_002655.2 hydrogenase activity 3635192 hycG 961295 hycG Escherichia coli O157:H7 str. EDL933 hydrogenase activity NP_289268.1 3634425 R 155864 CDS NP_289269.1 15803237 958178 complement(3635192..3635734) 1 NC_002655.2 electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate; formate hydrogenlyase complex iron-sulfur subunit 3635734 hycF 958178 hycF Escherichia coli O157:H7 str. EDL933 formate hydrogenlyase complex iron-sulfur subunit NP_289269.1 3635192 R 155864 CDS NP_289270.1 15803238 958180 complement(3635744..3637453) 1 NC_002655.2 large subunit of hydrogenase 3 (part of FHL complex) 3637453 hycE 958180 hycE Escherichia coli O157:H7 str. EDL933 large subunit of hydrogenase 3 (part of FHL complex) NP_289270.1 3635744 R 155864 CDS NP_289271.1 15803239 959323 complement(3637471..3638394) 1 NC_002655.2 membrane-spanning protein of hydrogenase 3 (part of FHL complex) 3638394 hycD 959323 hycD Escherichia coli O157:H7 str. EDL933 membrane-spanning protein of hydrogenase 3 (part of FHL complex) NP_289271.1 3637471 R 155864 CDS NP_289272.1 15803240 958062 complement(3638397..3640223) 1 NC_002655.2 catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3); formate hydrogenlyase subunit 3 3640223 hycC 958062 hycC Escherichia coli O157:H7 str. EDL933 formate hydrogenlyase subunit 3 NP_289272.1 3638397 R 155864 CDS NP_289273.1 15803241 958181 complement(3640220..3640831) 1 NC_002655.2 small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) 3640831 hycB 958181 hycB Escherichia coli O157:H7 str. EDL933 small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) NP_289273.1 3640220 R 155864 CDS NP_289274.1 15803242 958172 complement(3640956..3641417) 1 NC_002655.2 regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon; formate hydrogenlyase regulatory protein HycA 3641417 hycA 958172 hycA Escherichia coli O157:H7 str. EDL933 formate hydrogenlyase regulatory protein HycA NP_289274.1 3640956 R 155864 CDS NP_289275.1 15803243 958854 complement(3641451..3641588) 1 NC_002655.2 No significant matches; hypothetical protein 3641588 958854 Z4034 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289275.1 3641451 R 155864 CDS NP_289276.1 15803244 958185 3641629..3641979 1 NC_002655.2 plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein 3641979 hypA 958185 hypA Escherichia coli O157:H7 str. EDL933 hydrogenase nickel incorporation protein NP_289276.1 3641629 D 155864 CDS NP_289277.1 15803245 958186 3641983..3642855 1 NC_002655.2 GTP hydrolase involved in nickel liganding into hydrogenases; hydrogenase nickel incorporation protein HypB 3642855 hypB 958186 hypB Escherichia coli O157:H7 str. EDL933 hydrogenase nickel incorporation protein HypB NP_289277.1 3641983 D 155864 CDS NP_289278.1 15803246 958189 3642846..3643118 1 NC_002655.2 HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase; hydrogenase assembly chaperone 3643118 hypC 958189 hypC Escherichia coli O157:H7 str. EDL933 hydrogenase assembly chaperone NP_289278.1 3642846 D 155864 CDS NP_289279.1 15803247 958190 3643118..3644239 1 NC_002655.2 pleiotrophic effects on 3 hydrogenase isozymes 3644239 hypD 958190 hypD Escherichia coli O157:H7 str. EDL933 pleiotrophic effects on 3 hydrogenase isozymes NP_289279.1 3643118 D 155864 CDS NP_289280.1 15803248 959715 3644278..3645246 1 NC_002655.2 plays structural role in maturation of all 3 hydrogenase 3645246 hypE 959715 hypE Escherichia coli O157:H7 str. EDL933 plays structural role in maturation of all 3 hydrogenase NP_289280.1 3644278 D 155864 CDS NP_289281.1 15803249 959312 3645320..3647398 1 NC_002655.2 formate hydrogenlyase transcriptional activator 3647398 fhlA 959312 fhlA Escherichia coli O157:H7 str. EDL933 formate hydrogenlyase transcriptional activator NP_289281.1 3645320 D 155864 CDS NP_289282.1 15803250 958192 complement(3647435..3647788) 1 NC_002655.2 hypothetical protein 3647788 ygbA 958192 ygbA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289282.1 3647435 R 155864 CDS NP_289283.1 15803251 958196 complement(3647865..3647999) 1 NC_002655.2 No significant matches; hypothetical protein 3647999 958196 Z4042 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289283.1 3647865 R 155864 CDS NP_289284.1 15803252 960689 3648075..3650636 1 NC_002655.2 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 3650636 mutS 960689 mutS Escherichia coli O157:H7 str. EDL933 DNA mismatch repair protein MutS NP_289284.1 3648075 D 155864 CDS NP_289285.1 15803253 958197 3650742..3651398 1 NC_002655.2 serine/threonine-specific protein phosphatase 2 3651398 pphB 958197 pphB Escherichia coli O157:H7 str. EDL933 serine/threonine-specific protein phosphatase 2 NP_289285.1 3650742 D 155864 CDS NP_289286.1 15803254 958176 complement(3651439..3651675) 1 NC_002655.2 hypothetical protein 3651675 958176 Z4045 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289286.1 3651439 R 155864 CDS NP_289287.1 15803255 958198 complement(3651686..3653113) 1 NC_002655.2 hypothetical protein 3653113 958198 Z4046 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289287.1 3651686 R 155864 CDS NP_289288.1 15803256 958201 complement(3653113..3653706) 1 NC_002655.2 decarboxylase 3653706 958201 Z4047 Escherichia coli O157:H7 str. EDL933 decarboxylase NP_289288.1 3653113 R 155864 CDS NP_289289.1 15803257 956807 3653820..3654260 1 NC_002655.2 regulator 3654260 956807 Z4048 Escherichia coli O157:H7 str. EDL933 regulator NP_289289.1 3653820 D 155864 CDS NP_289290.1 15803258 960243 complement(3654380..3655372) 1 NC_002655.2 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses; RNA polymerase sigma factor RpoS 3655372 rpoS 960243 rpoS Escherichia coli O157:H7 str. EDL933 RNA polymerase sigma factor RpoS NP_289290.1 3654380 R 155864 CDS NP_289291.1 15803259 958191 complement(3655435..3656574) 1 NC_002655.2 outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus; lipoprotein NlpD 3656574 nlpD 958191 nlpD Escherichia coli O157:H7 str. EDL933 lipoprotein NlpD NP_289291.1 3655435 R 155864 CDS NP_289292.1 15803260 958203 complement(3656714..3657340) 1 NC_002655.2 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins; protein-L-isoaspartate O-methyltransferase 3657340 pcm 958203 pcm Escherichia coli O157:H7 str. EDL933 protein-L-isoaspartate O-methyltransferase NP_289292.1 3656714 R 155864 CDS NP_289293.1 15803261 958038 complement(3657334..3658095) 1 NC_002655.2 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE 3658095 surE 958038 surE Escherichia coli O157:H7 str. EDL933 stationary phase survival protein SurE NP_289293.1 3657334 R 155864 CDS NP_289294.1 15803262 959812 complement(3658076..3659125) 1 NC_002655.2 catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D 3659125 truD 959812 truD Escherichia coli O157:H7 str. EDL933 tRNA pseudouridine synthase D NP_289294.1 3658076 R 155864 CDS NP_289295.1 15803263 958205 complement(3659122..3659601) 1 NC_002655.2 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 3659601 ispF 958205 ispF Escherichia coli O157:H7 str. EDL933 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase NP_289295.1 3659122 R 155864 CDS NP_289296.1 15803264 958207 complement(3659601..3660311) 1 NC_002655.2 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 3660311 ispD 958207 ispD Escherichia coli O157:H7 str. EDL933 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase NP_289296.1 3659601 R 155864 CDS NP_289297.1 15803265 958045 complement(3660330..3660641) 1 NC_002655.2 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB 3660641 ftsB 958045 ftsB Escherichia coli O157:H7 str. EDL933 cell division protein FtsB NP_289297.1 3660330 R 155864 CDS NP_289298.1 15803266 957011 complement(3660835..3661158) 1 NC_002655.2 hypothetical protein 3661158 ygbE 957011 ygbE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289298.1 3660835 R 155864 CDS NP_289299.1 15803267 957346 complement(3661208..3661813) 1 NC_002655.2 converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis; adenylylsulfate kinase 3661813 cysC 957346 cysC Escherichia coli O157:H7 str. EDL933 adenylylsulfate kinase NP_289299.1 3661208 R 155864 CDS NP_289300.1 15803268 958208 complement(3661813..3663240) 1 NC_002655.2 may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ; sulfate adenylyltransferase subunit 1 3663240 cysN 958208 cysN Escherichia coli O157:H7 str. EDL933 sulfate adenylyltransferase subunit 1 NP_289300.1 3661813 R 155864 CDS NP_289301.1 15803269 958209 complement(3663242..3664150) 1 NC_002655.2 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 3664150 cysD 958209 cysD Escherichia coli O157:H7 str. EDL933 sulfate adenylyltransferase subunit 2 NP_289301.1 3663242 R 155864 CDS NP_289302.1 15803270 959560 3664402..3665439 1 NC_002655.2 catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3; alkaline phosphatase 3665439 iap 959560 iap Escherichia coli O157:H7 str. EDL933 alkaline phosphatase NP_289302.1 3664402 D 155864 CDS NP_289303.1 15803271 960428 complement(3665829..3666122) 1 NC_002655.2 hypothetical protein 3666122 ygbF 960428 ygbF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289303.1 3665829 R 155864 CDS NP_289304.1 15803272 960422 complement(3666119..3667042) 1 NC_002655.2 hypothetical protein 3667042 960422 Z4064 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289304.1 3666119 R 155864 CDS NP_289305.1 15803273 958213 complement(3667039..3667689) 1 NC_002655.2 hypothetical protein 3667689 958213 Z4065 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289305.1 3667039 R 155864 CDS NP_289306.1 15803274 958216 complement(3667671..3668417) 1 NC_002655.2 hypothetical protein 3668417 958216 Z4066 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289306.1 3667671 R 155864 CDS NP_289307.1 15803275 958217 complement(3668428..3669483) 1 NC_002655.2 hypothetical protein 3669483 958217 Z4067 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289307.1 3668428 R 155864 CDS NP_289308.1 15803276 959305 complement(3669495..3670031) 1 NC_002655.2 No significant matches; hypothetical protein 3670031 959305 Z4068 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289308.1 3669495 R 155864 CDS NP_289309.1 15803277 959497 complement(3670028..3671590) 1 NC_002655.2 hypothetical protein 3671590 959497 Z4069 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289309.1 3670028 R 155864 CDS NP_289310.1 15803278 958379 complement(3671688..3674387) 1 NC_002655.2 hypothetical protein 3674387 ygcB 958379 ygcB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289310.1 3671688 R 155864 CDS NP_289311.1 15803279 958220 complement(3674579..3674731) 1 NC_002655.2 hypothetical protein 3674731 958220 Z4071 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289311.1 3674579 R 155864 CDS NP_289312.1 15803280 958221 complement(3674995..3675729) 1 NC_002655.2 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 3675729 cysH 958221 cysH Escherichia coli O157:H7 str. EDL933 phosphoadenosine phosphosulfate reductase NP_289312.1 3674995 R 155864 CDS NP_289313.1 15803281 959281 complement(3675803..3677515) 1 NC_002655.2 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta 3677515 cysI 959281 cysI Escherichia coli O157:H7 str. EDL933 sulfite reductase subunit beta NP_289313.1 3675803 R 155864 CDS NP_289314.1 15803282 959221 complement(3677515..3679314) 1 NC_002655.2 catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity; sulfite reductase subunit alpha 3679314 cysJ 959221 cysJ Escherichia coli O157:H7 str. EDL933 sulfite reductase subunit alpha NP_289314.1 3677515 R 155864 CDS NP_289315.1 15803283 961174 3679630..3679995 1 NC_002655.2 6-pyruvoyl tetrahydrobiopterin synthase 3679995 ygcM 961174 ygcM Escherichia coli O157:H7 str. EDL933 6-pyruvoyl tetrahydrobiopterin synthase NP_289315.1 3679630 D 155864 CDS NP_289316.1 15803284 958222 3680043..3681344 1 NC_002655.2 hypothetical protein 3681344 ygcN 958222 ygcN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289316.1 3680043 D 155864 CDS NP_289317.1 15803285 957041 3681299..3681595 1 NC_002655.2 hypothetical protein 3681595 957041 Z4077 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289317.1 3681299 D 155864 CDS NP_289318.1 15803286 958115 3681612..3682187 1 NC_002655.2 anti-terminator regulatory protein 3682187 ygcP 958115 ygcP Escherichia coli O157:H7 str. EDL933 anti-terminator regulatory protein NP_289318.1 3681612 D 155864 CDS NP_289319.1 15803287 958228 complement(3682335..3682610) 1 NC_002655.2 hypothetical protein 3682610 958228 Z4079 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289319.1 3682335 R 155864 CDS NP_289320.1 15803288 958229 complement(3682626..3683195) 1 NC_002655.2 hypothetical protein 3683195 958229 Z4080 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289320.1 3682626 R 155864 CDS NP_289321.1 15803289 958230 complement(3683192..3683977) 1 NC_002655.2 transporter 3683977 ygcR 958230 ygcR Escherichia coli O157:H7 str. EDL933 transporter NP_289321.1 3683192 R 155864 CDS NP_289322.1 15804979 959643 complement(join(3683949..3684266,3684266..3685357)) 1 NC_002655.2 major facilitator superfamily permease 3685357 959643 Z4083m Escherichia coli O157:H7 str. EDL933 major facilitator superfamily permease NP_289322.1 3683949 R 155864 CDS NP_289323.1 15803290 958231 complement(3685379..3686173) 1 NC_002655.2 alkyl-dihydroxyacetonephosphate synthase 3686173 958231 Z4084 Escherichia coli O157:H7 str. EDL933 alkyl-dihydroxyacetonephosphate synthase NP_289323.1 3685379 R 155864 CDS NP_289324.1 15803291 958234 complement(3686903..3687763) 1 NC_002655.2 oxidoreductase 3687763 ygcW 958234 ygcW Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_289324.1 3686903 R 155864 CDS NP_289325.1 15803292 958235 3688007..3689284 1 NC_002655.2 transporter 3689284 yqcE 958235 yqcE Escherichia coli O157:H7 str. EDL933 transporter NP_289325.1 3688007 D 155864 CDS NP_289326.1 15803293 958236 3689311..3690789 1 NC_002655.2 kinase 3690789 ygcE 958236 ygcE Escherichia coli O157:H7 str. EDL933 kinase NP_289326.1 3689311 D 155864 CDS NP_289328.1 15803295 958233 complement(3691853..3692524) 1 NC_002655.2 hypothetical protein 3692524 ygcF 958233 ygcF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289328.1 3691853 R 155864 CDS NP_289329.1 15803296 958240 3692805..3693299 1 NC_002655.2 hypothetical protein 3693299 958240 Z4090 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289329.1 3692805 D 155864 CDS NP_289330.1 15803297 958239 3693289..3693987 1 NC_002655.2 hypothetical protein 3693987 958239 Z4091 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289330.1 3693289 D 155864 CDS NP_289331.1 15803298 959390 3694221..3695369 1 NC_002655.2 hypothetical protein 3695369 959390 Z4092 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289331.1 3694221 D 155864 CDS NP_289332.1 15803299 958242 3695375..3696280 1 NC_002655.2 hypothetical protein 3696280 958242 Z4093 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289332.1 3695375 D 155864 CDS NP_289333.1 15803300 958245 complement(3696340..3697638) 1 NC_002655.2 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 3697638 eno 958245 eno Escherichia coli O157:H7 str. EDL933 phosphopyruvate hydratase NP_289333.1 3696340 R 155864 CDS NP_289334.1 15803301 958246 complement(3697726..3699363) 1 NC_002655.2 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 3699363 pyrG 958246 pyrG Escherichia coli O157:H7 str. EDL933 CTP synthetase NP_289334.1 3697726 R 155864 CDS NP_289335.1 15803302 958247 complement(3699591..3700382) 1 NC_002655.2 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase Era; nucleoside triphosphate pyrophosphohydrolase 3700382 mazG 958247 mazG Escherichia coli O157:H7 str. EDL933 nucleoside triphosphate pyrophosphohydrolase NP_289335.1 3699591 R 155864 CDS NP_289336.1 15803303 958248 complement(3700453..3700788) 1 NC_002655.2 MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system; toxin ChpA 3700788 chpA 958248 chpA Escherichia coli O157:H7 str. EDL933 toxin ChpA NP_289336.1 3700453 R 155864 CDS NP_289337.1 15803304 958252 complement(3700788..3701036) 1 NC_002655.2 part of the MazF-MazE toxin-antitoxin system; conteracts MazF; antitoxin MazE 3701036 chpR 958252 chpR Escherichia coli O157:H7 str. EDL933 antitoxin MazE NP_289337.1 3700788 R 155864 CDS NP_289338.1 15803305 958253 complement(3701114..3703348) 1 NC_002655.2 (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP; GDP/GTP pyrophosphokinase 3703348 relA 958253 relA Escherichia coli O157:H7 str. EDL933 GDP/GTP pyrophosphokinase NP_289338.1 3701114 R 155864 CDS NP_289339.1 15803306 958250 complement(3703396..3704697) 1 NC_002655.2 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase 3704697 rumA 958250 rumA Escherichia coli O157:H7 str. EDL933 23S rRNA 5-methyluridine methyltransferase NP_289339.1 3703396 R 155864 CDS NP_289340.1 15803307 958008 3704754..3707510 1 NC_002655.2 part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system; hybrid sensory histidine kinase BarA 3707510 barA 958008 barA Escherichia coli O157:H7 str. EDL933 hybrid sensory histidine kinase BarA NP_289340.1 3704754 D 155864 CDS NP_289341.1 15803308 958251 complement(3707743..3709083) 1 NC_002655.2 glucarate dehydratase 3709083 ygcX 958251 ygcX Escherichia coli O157:H7 str. EDL933 glucarate dehydratase NP_289341.1 3707743 R 155864 CDS NP_289342.1 15803309 958256 complement(3709104..3710201) 1 NC_002655.2 glucarate dehydratase 3710201 ygcY 958256 ygcY Escherichia coli O157:H7 str. EDL933 glucarate dehydratase NP_289342.1 3709104 R 155864 CDS NP_289343.1 15803310 958257 complement(3710223..3710444) 1 NC_002655.2 hypothetical protein 3710444 958257 Z4104 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289343.1 3710223 R 155864 CDS NP_289344.1 15803311 958258 complement(3710446..3711798) 1 NC_002655.2 transporter 3711798 958258 Z4105 Escherichia coli O157:H7 str. EDL933 transporter NP_289344.1 3710446 R 155864 CDS NP_289345.1 15803312 958259 complement(3712233..3712682) 1 NC_002655.2 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 3712682 958259 Z4106 Escherichia coli O157:H7 str. EDL933 flavodoxin NP_289345.1 3712233 R 155864 CDS NP_289346.1 15803313 957078 complement(3712700..3713482) 1 NC_002655.2 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C 3713482 957078 Z4107 Escherichia coli O157:H7 str. EDL933 tRNA pseudouridine synthase C NP_289346.1 3712700 R 155864 CDS NP_289347.1 15803314 958307 complement(3713482..3713811) 1 NC_002655.2 hypothetical protein 3713811 958307 Z4108 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289347.1 3713482 R 155864 CDS NP_289348.1 15803315 958261 complement(3714433..3714978) 1 NC_002655.2 SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function; SecY interacting protein Syd 3714978 syd 958261 syd Escherichia coli O157:H7 str. EDL933 SecY interacting protein Syd NP_289348.1 3714433 R 155864 CDS NP_289349.1 15803316 956767 3715046..3715894 1 NC_002655.2 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 3715894 queF 956767 queF Escherichia coli O157:H7 str. EDL933 7-cyano-7-deazaguanine reductase NP_289349.1 3715046 D 155864 CDS NP_289350.1 15803317 958262 3716006..3717370 1 NC_002655.2 hypothetical protein 3717370 ygdH 958262 ygdH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289350.1 3716006 D 155864 CDS NP_289351.1 15803318 958263 3717927..3719216 1 NC_002655.2 serine transporter 3719216 sdaC 958263 sdaC Escherichia coli O157:H7 str. EDL933 serine transporter NP_289351.1 3717927 D 155864 CDS NP_289352.1 15803319 958265 3719274..3720641 1 NC_002655.2 L-serine dehydratase 3720641 sdaB 958265 sdaB Escherichia coli O157:H7 str. EDL933 L-serine dehydratase NP_289352.1 3719274 D 155864 CDS NP_289353.1 15803320 958266 3720663..3721508 1 NC_002655.2 has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups; exonuclease IX 3721508 xni 958266 xni Escherichia coli O157:H7 str. EDL933 exonuclease IX NP_289353.1 3720663 D 155864 CDS NP_289354.1 15803321 958299 complement(3721563..3722714) 1 NC_002655.2 L-1,2-propanediol oxidoreductase 3722714 fucO 958299 fucO Escherichia coli O157:H7 str. EDL933 L-1,2-propanediol oxidoreductase NP_289354.1 3721563 R 155864 CDS NP_289355.1 15803322 958302 complement(3722739..3723386) 1 NC_002655.2 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase 3723386 fucA 958302 fucA Escherichia coli O157:H7 str. EDL933 L-fuculose phosphate aldolase NP_289355.1 3722739 R 155864 CDS NP_289356.1 15803323 957232 3723933..3725249 1 NC_002655.2 L-fucose transporter 3725249 fucP 957232 fucP Escherichia coli O157:H7 str. EDL933 L-fucose transporter NP_289356.1 3723933 D 155864 CDS NP_289357.1 15803324 958301 3725282..3727057 1 NC_002655.2 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 3727057 fucI 958301 fucI Escherichia coli O157:H7 str. EDL933 L-fucose isomerase NP_289357.1 3725282 D 155864 CDS NP_289358.1 15803325 958268 3727136..3728584 1 NC_002655.2 L-fuculokinase 3728584 fucK 958268 fucK Escherichia coli O157:H7 str. EDL933 L-fuculokinase NP_289358.1 3727136 D 155864 CDS NP_289359.1 15803326 958270 3728586..3729008 1 NC_002655.2 protein of fucose operon 3729008 fucU 958270 fucU Escherichia coli O157:H7 str. EDL933 protein of fucose operon NP_289359.1 3728586 D 155864 CDS NP_289360.1 15803327 958272 3729066..3729797 1 NC_002655.2 regulates expression of genes involved in L-fucose utilization; DNA-binding transcriptional activator FucR 3729797 fucR 958272 fucR Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional activator FucR NP_289360.1 3729066 D 155864 CDS NP_289361.1 15803328 958273 complement(3729841..3730941) 1 NC_002655.2 RNA 2'-O-ribose methyltransferase 3730941 ygdE 958273 ygdE Escherichia coli O157:H7 str. EDL933 RNA 2'-O-ribose methyltransferase NP_289361.1 3729841 R 155864 CDS NP_289362.1 15803329 958274 complement(3730934..3731329) 1 NC_002655.2 hypothetical protein 3731329 ygdD 958274 ygdD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289362.1 3730934 R 155864 CDS NP_289363.1 15803330 958267 complement(3731348..3732265) 1 NC_002655.2 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA 3732265 gcvA 958267 gcvA Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional activator GcvA NP_289363.1 3731348 R 155864 CDS NP_289364.1 15803331 958947 complement(3732616..3732846) 1 NC_002655.2 hypothetical protein 3732846 958947 Z4126 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289364.1 3732616 R 155864 CDS NP_289365.1 15803332 956864 3733035..3734240 1 NC_002655.2 cysteine sulfinate desulfinase 3734240 956864 Z4127 Escherichia coli O157:H7 str. EDL933 cysteine sulfinate desulfinase NP_289365.1 3733035 D 155864 CDS NP_289366.1 15803333 958277 3734240..3734683 1 NC_002655.2 hypothetical protein 3734683 ygdK 958277 ygdK Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289366.1 3734240 D 155864 CDS NP_289367.1 15803334 958278 complement(3734734..3735540) 1 NC_002655.2 hypothetical protein 3735540 ygdL 958278 ygdL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289367.1 3734734 R 155864 CDS NP_289368.1 15803335 958279 complement(3735779..3736876) 1 NC_002655.2 membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase A 3736876 mltA 958279 mltA Escherichia coli O157:H7 str. EDL933 murein transglycosylase A NP_289368.1 3735779 R 155864 CDS NP_289369.1 15803336 959411 complement(3737455..3738798) 1 NC_002655.2 amidase 3738798 959411 Z4134 Escherichia coli O157:H7 str. EDL933 amidase NP_289369.1 3737455 R 155864 CDS NP_289370.1 15803337 957960 3738940..3740271 1 NC_002655.2 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase 3740271 argA 957960 argA Escherichia coli O157:H7 str. EDL933 N-acetylglutamate synthase NP_289370.1 3738940 D 155864 CDS NP_289371.1 15803338 958288 complement(3740333..3742159) 1 NC_002655.2 helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit alpha 3742159 recD 958288 recD Escherichia coli O157:H7 str. EDL933 exonuclease V subunit alpha NP_289371.1 3740333 R 155864 CDS NP_289372.1 15803339 958289 complement(3742159..3745701) 1 NC_002655.2 helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit beta 3745701 recB 958289 recB Escherichia coli O157:H7 str. EDL933 exonuclease V subunit beta NP_289372.1 3742159 R 155864 CDS NP_289373.1 15803340 958290 complement(3745694..3748582) 1 NC_002655.2 protease III 3748582 ptr 958290 ptr Escherichia coli O157:H7 str. EDL933 protease III NP_289373.1 3745694 R 155864 CDS NP_289374.1 15803341 958276 complement(3748758..3752126) 1 NC_002655.2 catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination; exonuclease V subunit gamma 3752126 recC 958276 recC Escherichia coli O157:H7 str. EDL933 exonuclease V subunit gamma NP_289374.1 3748758 R 155864 CDS NP_289375.1 15803342 958296 complement(3752139..3752462) 1 NC_002655.2 hypothetical protein 3752462 ppdC 958296 ppdC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289375.1 3752139 R 155864 CDS NP_289376.2 161367538 958291 complement(3752447..3752854) 1 NC_002655.2 hypothetical protein 3752854 ygdB 958291 ygdB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289376.2 3752447 R 155864 CDS NP_289377.1 15803344 961190 complement(3752851..3753414) 1 NC_002655.2 hypothetical protein 3753414 ppdB 961190 ppdB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289377.1 3752851 R 155864 CDS NP_289378.1 15803345 958545 complement(3753405..3753875) 1 NC_002655.2 hypothetical protein 3753875 ppdA 958545 ppdA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289378.1 3753405 R 155864 CDS NP_289379.1 15803346 959426 complement(3754059..3754853) 1 NC_002655.2 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 3754853 thyA 959426 thyA Escherichia coli O157:H7 str. EDL933 thymidylate synthase NP_289379.1 3754059 R 155864 CDS NP_289380.1 15803347 958292 complement(3754860..3755735) 1 NC_002655.2 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 3755735 lgt 958292 lgt Escherichia coli O157:H7 str. EDL933 prolipoprotein diacylglyceryl transferase NP_289380.1 3754860 R 155864 CDS NP_289381.1 15803348 958294 complement(3755886..3758132) 1 NC_002655.2 member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr; fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain 3758132 ptsP 958294 ptsP Escherichia coli O157:H7 str. EDL933 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain NP_289381.1 3755886 R 155864 CDS NP_289382.1 15803349 958297 complement(3758145..3758675) 1 NC_002655.2 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 3758675 ygdP 958297 ygdP Escherichia coli O157:H7 str. EDL933 dinucleoside polyphosphate hydrolase NP_289382.1 3758145 R 155864 CDS NP_289383.1 15803350 958298 complement(3759028..3759174) 1 NC_002655.2 No significant matches; hypothetical protein 3759174 958298 Z4148 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289383.1 3759028 R 155864 CDS NP_289384.1 15803351 958300 3759360..3760049 1 NC_002655.2 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 3760049 mutH 958300 mutH Escherichia coli O157:H7 str. EDL933 DNA mismatch repair protein NP_289384.1 3759360 D 155864 CDS NP_289385.1 15803352 958303 3760118..3760831 1 NC_002655.2 transporter 3760831 958303 Z4150 Escherichia coli O157:H7 str. EDL933 transporter NP_289385.1 3760118 D 155864 CDS NP_289386.1 15803353 958295 3760969..3761187 1 NC_002655.2 hypothetical protein 3761187 958295 Z4151 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289386.1 3760969 D 155864 CDS NP_289387.1 15803354 958310 3761295..3762335 1 NC_002655.2 complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH; aldo/keto reductase 3762335 tas 958310 tas Escherichia coli O157:H7 str. EDL933 aldo/keto reductase NP_289387.1 3761295 D 155864 CDS NP_289388.1 15803355 957841 complement(3762367..3763560) 1 NC_002655.2 lysophospholipid transporter LplT 3763560 ygeD 957841 ygeD Escherichia coli O157:H7 str. EDL933 lysophospholipid transporter LplT NP_289388.1 3762367 R 155864 CDS NP_289389.1 15803356 958304 complement(3763553..3765712) 1 NC_002655.2 Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase 3765712 aas 958304 aas Escherichia coli O157:H7 str. EDL933 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase NP_289389.1 3763553 R 155864 CDS NP_289390.1 15803357 958305 3766299..3767330 1 NC_002655.2 controls transcription of galETKM; DNA-binding transcriptional regulator GalR 3767330 galR 958305 galR Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator GalR NP_289390.1 3766299 D 155864 CDS NP_289391.1 15803358 958308 complement(3767337..3768599) 1 NC_002655.2 catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding; diaminopimelate decarboxylase 3768599 lysA 958308 lysA Escherichia coli O157:H7 str. EDL933 diaminopimelate decarboxylase NP_289391.1 3767337 R 155864 CDS NP_289392.1 15803359 958309 3768721..3769656 1 NC_002655.2 activates the transcription of the lysA gene encoding diaminopimelate decarboxylase; LysR family transcriptional regulator 3769656 lysR 958309 lysR Escherichia coli O157:H7 str. EDL933 LysR family transcriptional regulator NP_289392.1 3768721 D 155864 CDS NP_289393.1 15803360 959363 complement(3769643..3770335) 1 NC_002655.2 racemase 3770335 ygeA 959363 ygeA Escherichia coli O157:H7 str. EDL933 racemase NP_289393.1 3769643 R 155864 CDS NP_289394.1 15803361 958165 complement(3770464..3771882) 1 NC_002655.2 low-affinity L-arabinose transport system proton symport protein 3771882 araE 958165 araE Escherichia coli O157:H7 str. EDL933 low-affinity L-arabinose transport system proton symport protein NP_289394.1 3770464 R 155864 CDS NP_289395.1 15803362 959349 complement(3772197..3772958) 1 NC_002655.2 catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate; 2-deoxy-D-gluconate 3-dehydrogenase 3772958 kduD 959349 kduD Escherichia coli O157:H7 str. EDL933 2-deoxy-D-gluconate 3-dehydrogenase NP_289395.1 3772197 R 155864 CDS NP_289396.1 15803363 958313 complement(3772988..3773824) 1 NC_002655.2 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate; 5-keto-4-deoxyuronate isomerase 3773824 kduI 958313 kduI Escherichia coli O157:H7 str. EDL933 5-keto-4-deoxyuronate isomerase NP_289396.1 3772988 R 155864 CDS NP_289397.2 161367537 958314 complement(3774111..3775292) 1 NC_002655.2 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase 3775292 yqeF 958314 yqeF Escherichia coli O157:H7 str. EDL933 acetyl-CoA acetyltransferase NP_289397.2 3774111 R 155864 CDS NP_289398.1 15803365 958315 3775547..3776776 1 NC_002655.2 transporter protein 3776776 958315 Z4165 Escherichia coli O157:H7 str. EDL933 transporter protein NP_289398.1 3775547 D 155864 CDS NP_289399.1 15803366 956916 3777176..3777868 1 NC_002655.2 hypothetical protein 3777868 yqeH 956916 yqeH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289399.1 3777176 D 155864 CDS NP_289400.1 15803367 957233 3778202..3779011 1 NC_002655.2 sensory transducer 3779011 yqeI 957233 yqeI Escherichia coli O157:H7 str. EDL933 sensory transducer NP_289400.1 3778202 D 155864 CDS NP_289401.1 15803368 958999 3779095..3779487 1 NC_002655.2 hypothetical protein 3779487 yqeJ 958999 yqeJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289401.1 3779095 D 155864 CDS NP_289402.1 15803369 958318 complement(3779636..3780073) 1 NC_002655.2 hypothetical protein 3780073 yqeK 958318 yqeK Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289402.1 3779636 R 155864 CDS NP_289403.1 15803370 958517 complement(3780201..3780437) 1 NC_002655.2 No significant matches; hypothetical protein 3780437 958517 Z4170 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289403.1 3780201 R 155864 CDS NP_289404.1 15803371 958503 3780491..3780982 1 NC_002655.2 hypothetical protein 3780982 958503 Z4171 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289404.1 3780491 D 155864 CDS NP_289405.1 15803372 958319 3781208..3781699 1 NC_002655.2 hypothetical protein 3781699 ygeG 958319 ygeG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289405.1 3781208 D 155864 CDS NP_289406.1 15803373 958321 3782034..3783410 1 NC_002655.2 transcriptional regulator 3783410 ygeH 958321 ygeH Escherichia coli O157:H7 str. EDL933 transcriptional regulator NP_289406.1 3782034 D 155864 CDS NP_289407.1 15803374 958322 3783577..3783795 1 NC_002655.2 hypothetical protein 3783795 958322 Z4174 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289407.1 3783577 D 155864 CDS NP_289408.1 15803375 958323 3783880..3784383 1 NC_002655.2 hypothetical protein 3784383 958323 Z4175 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289408.1 3783880 D 155864 CDS NP_289409.1 15803376 958324 complement(3784402..3784848) 1 NC_002655.2 2-component transcriptional regulator 3784848 958324 Z4176 Escherichia coli O157:H7 str. EDL933 2-component transcriptional regulator NP_289409.1 3784402 R 155864 CDS NP_289410.1 15803377 959541 3785201..3785335 1 NC_002655.2 No significant matches; hypothetical protein 3785335 959541 Z4177 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289410.1 3785201 D 155864 CDS NP_289411.1 15803378 958135 complement(3785257..3785688) 1 NC_002655.2 hypothetical protein 3785688 958135 Z4178 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289411.1 3785257 R 155864 CDS NP_289412.1 15803379 958326 complement(3785705..3785965) 1 NC_002655.2 hypothetical protein 3785965 958326 Z4179 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289412.1 3785705 R 155864 CDS NP_289413.1 15803380 961173 complement(3786504..3787238) 1 NC_002655.2 lipoprotein of type III secretion apparatus 3787238 961173 Z4180 Escherichia coli O157:H7 str. EDL933 lipoprotein of type III secretion apparatus NP_289413.1 3786504 R 155864 CDS NP_289414.1 15803381 957709 complement(3787235..3787567) 1 NC_002655.2 Type III secretion apparatus protein 3787567 957709 Z4181 Escherichia coli O157:H7 str. EDL933 Type III secretion apparatus protein NP_289414.1 3787235 R 155864 CDS NP_289415.1 15803382 959507 complement(3787866..3788654) 1 NC_002655.2 hypothetical protein 3788654 959507 Z4182 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289415.1 3787866 R 155864 CDS NP_289416.1 15803383 958330 complement(3788951..3789034) 1 NC_002655.2 No significant matches; hypothetical protein 3789034 958330 Z4183 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289416.1 3788951 R 155864 CDS NP_289417.1 15803384 956948 3789283..3789783 1 NC_002655.2 No significant matches; hypothetical protein 3789783 956948 Z4184 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289417.1 3789283 D 155864 CDS NP_289418.1 15803385 957768 complement(3790140..3791261) 1 NC_002655.2 Required for surface presentation of invasion plasmid antigens; required for invasion and for secretion of the three ipa proteins; surface presentation of antigens protein SpaS 3791261 957768 Z4185 Escherichia coli O157:H7 str. EDL933 surface presentation of antigens protein SpaS NP_289418.1 3790140 R 155864 CDS NP_289419.1 15803386 958328 complement(3791270..3791506) 1 NC_002655.2 integral membrane protein-component of typeIII secretion apparatus 3791506 958328 Z4186 Escherichia coli O157:H7 str. EDL933 integral membrane protein-component of typeIII secretion apparatus NP_289419.1 3791270 R 155864 CDS NP_289420.1 15803387 958332 complement(3791585..3792037) 1 NC_002655.2 type III secretion apparatus protein 3792037 958332 Z4187 Escherichia coli O157:H7 str. EDL933 type III secretion apparatus protein NP_289420.1 3791585 R 155864 CDS NP_289421.1 15803388 958333 complement(3792039..3792299) 1 NC_002655.2 type III secretion apparatus protein 3792299 958333 Z4188 Escherichia coli O157:H7 str. EDL933 type III secretion apparatus protein NP_289421.1 3792039 R 155864 CDS NP_289422.1 15803389 958334 complement(3792310..3792975) 1 NC_002655.2 part of a type III secretory system probably involved in invasion into eukaryotic cells; surface presentation of antigens protein SpaP 3792975 spaP 958334 spaP Escherichia coli O157:H7 str. EDL933 surface presentation of antigens protein SpaP NP_289422.1 3792310 R 155864 CDS NP_289423.1 15803390 958331 complement(3792965..3793951) 1 NC_002655.2 involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells; surface presentation of antigens protein SpaO 3793951 958331 Z4190 Escherichia coli O157:H7 str. EDL933 surface presentation of antigens protein SpaO NP_289423.1 3792965 R 155864 CDS NP_289424.1 15803391 958336 complement(3793911..3794480) 1 NC_002655.2 type III secretion apparatus protein 3794480 958336 Z4191 Escherichia coli O157:H7 str. EDL933 type III secretion apparatus protein NP_289424.1 3793911 R 155864 CDS NP_289425.1 15803392 957826 complement(3794553..3794786) 1 NC_002655.2 No significant matches; hypothetical protein 3794786 957826 Z4192 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289425.1 3794553 R 155864 CDS NP_289426.1 15803393 961154 complement(3794764..3795099) 1 NC_002655.2 type III secretion apparatus protein 3795099 961154 Z4193 Escherichia coli O157:H7 str. EDL933 type III secretion apparatus protein NP_289426.1 3794764 R 155864 CDS NP_289427.1 15803394 957284 complement(3795212..3796531) 1 NC_002655.2 Invasion protein InvC; necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase; ATP synthase SpaL 3796531 957284 Z4194 Escherichia coli O157:H7 str. EDL933 ATP synthase SpaL NP_289427.1 3795212 R 155864 CDS NP_289428.1 15803395 958340 complement(3796536..3798596) 1 NC_002655.2 type III secretion apparatus protein 3798596 958340 Z4195 Escherichia coli O157:H7 str. EDL933 type III secretion apparatus protein NP_289428.1 3796536 R 155864 CDS NP_289429.1 15803396 958345 complement(3798589..3799734) 1 NC_002655.2 hypothetical protein 3799734 958345 Z4196 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289429.1 3798589 R 155864 CDS NP_289430.1 15803397 958346 complement(3799739..3801442) 1 NC_002655.2 type III secretion apparatus protein 3801442 958346 Z4197 Escherichia coli O157:H7 str. EDL933 type III secretion apparatus protein NP_289430.1 3799739 R 155864 CDS NP_289431.1 15803398 958342 complement(3801439..3802188) 1 NC_002655.2 regulatory protein for type III secretion apparatus 3802188 958342 Z4198 Escherichia coli O157:H7 str. EDL933 regulatory protein for type III secretion apparatus NP_289431.1 3801439 R 155864 CDS NP_289432.1 15803399 958337 complement(3802534..3802713) 1 NC_002655.2 No significant matches; hypothetical protein 3802713 958337 Z4199 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289432.1 3802534 R 155864 CDS NP_289433.1 15803400 958343 complement(3802780..3803808) 1 NC_002655.2 hypothetical protein 3803808 958343 Z4200 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289433.1 3802780 R 155864 CDS NP_289434.1 15803401 958344 complement(3803822..3804427) 1 NC_002655.2 hypothetical protein 3804427 958344 Z4201 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289434.1 3803822 R 155864 CDS NP_289435.1 15803402 958227 complement(3804817..3805488) 1 NC_002655.2 lipoprotein 3805488 958227 Z4203 Escherichia coli O157:H7 str. EDL933 lipoprotein NP_289435.1 3804817 R 155864 CDS NP_289436.1 15803403 958353 3805982..3808240 1 NC_002655.2 molybdenum cofactor-binding protein; participates in purine salvage; xanthine dehydrogenase subunit XdhA 3808240 958353 Z4205 Escherichia coli O157:H7 str. EDL933 xanthine dehydrogenase subunit XdhA NP_289436.1 3805982 D 155864 CDS NP_289437.2 157267369 958358 3808251..3809129 1 NC_002655.2 FAD-binding subunit; with XdhA and XdhC participates in purine salvage; xanthine dehydrogenase subunit XdhB 3809129 ygeT 958358 ygeT Escherichia coli O157:H7 str. EDL933 xanthine dehydrogenase subunit XdhB NP_289437.2 3808251 D 155864 CDS NP_289438.1 15803405 959352 3809126..3809605 1 NC_002655.2 iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage; xanthine dehydrogenase subunit XdhC 3809605 959352 Z4207 Escherichia coli O157:H7 str. EDL933 xanthine dehydrogenase subunit XdhC NP_289438.1 3809126 D 155864 CDS NP_289439.1 15803406 958354 complement(3809645..3811423) 1 NC_002655.2 transcriptional regulator 3811423 ygeV 958354 ygeV Escherichia coli O157:H7 str. EDL933 transcriptional regulator NP_289439.1 3809645 R 155864 CDS NP_289440.1 15803407 958325 3811899..3813089 1 NC_002655.2 catalyzes the formation of L-citruline from L-ornithine and carbamoylphosphate; aspartate/ornithine carbamoyltransferase 3813089 958325 Z4209 Escherichia coli O157:H7 str. EDL933 aspartate/ornithine carbamoyltransferase NP_289440.1 3811899 D 155864 CDS NP_289441.1 15803408 958311 3813147..3814343 1 NC_002655.2 catalyzes the formation of pyruvate from 2,3-diaminopropionate; diaminopropionate ammonia-lyase 3814343 ygeX 958311 ygeX Escherichia coli O157:H7 str. EDL933 diaminopropionate ammonia-lyase NP_289441.1 3813147 D 155864 CDS NP_289442.1 15803409 958286 3814401..3815612 1 NC_002655.2 Zn-dependent extracellular dipeptidase; similar to succinyl-diaminopimelate desuccinylases; peptidase 3815612 ygeY 958286 ygeY Escherichia coli O157:H7 str. EDL933 peptidase NP_289442.1 3814401 D 155864 CDS NP_289443.2 161367536 958355 3815665..3817050 1 NC_002655.2 catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position; phenylhydantoinase 3817050 958355 Z4212 Escherichia coli O157:H7 str. EDL933 phenylhydantoinase NP_289443.2 3815665 D 155864 CDS NP_289444.1 15803411 958359 3817098..3818030 1 NC_002655.2 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 3818030 yqeA 958359 yqeA Escherichia coli O157:H7 str. EDL933 carbamate kinase NP_289444.1 3817098 D 155864 CDS NP_289445.1 15803412 958244 complement(3818071..3819696) 1 NC_002655.2 synthase 3819696 958244 Z4214 Escherichia coli O157:H7 str. EDL933 synthase NP_289445.1 3818071 R 155864 CDS NP_289446.1 15803413 958356 complement(3819744..3820451) 1 NC_002655.2 hypothetical protein 3820451 958356 Z4215 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289446.1 3819744 R 155864 CDS NP_289447.1 15803414 958360 3820617..3821195 1 NC_002655.2 hypothetical protein 3821195 ygfJ 958360 ygfJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289447.1 3820617 D 155864 CDS NP_289448.1 15803415 958362 3821519..3824617 1 NC_002655.2 with YgfM and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfK mutants are unable to reduce selenate; involved in purine salvage process; seems to act as an oxidoreductase, but sequence similarity suggests it is a dihydrothymine dehydrogenase; selenate reductase subunit YgfK 3824617 958362 Z4217 Escherichia coli O157:H7 str. EDL933 selenate reductase subunit YgfK NP_289448.1 3821519 D 155864 CDS NP_289449.2 161367535 958364 3824620..3825948 1 NC_002655.2 in Escherichia coli expression is induced in response to phase-specific signals and controlled by RpoS; chlorohydrolase/aminohydrolase 3825948 958364 Z4218 Escherichia coli O157:H7 str. EDL933 chlorohydrolase/aminohydrolase NP_289449.2 3824620 D 155864 CDS NP_289450.1 15803417 958366 3825998..3826777 1 NC_002655.2 with YgfK and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfM contains a FAD domain; selenate reductase subunit YgfM 3826777 958366 Z4219 Escherichia coli O157:H7 str. EDL933 selenate reductase subunit YgfM NP_289450.1 3825998 D 155864 CDS NP_289451.1 15803418 958859 3826774..3829644 1 NC_002655.2 with YgfK and YgfM forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; molybdopterin-containing enzyme; oxidase activity toward hypoxanthine and xanthine can be detected if these substrates are present at high concentration; selenate reductase subunit YgfN 3829644 958859 Z4220 Escherichia coli O157:H7 str. EDL933 selenate reductase subunit YgfN NP_289451.1 3826774 D 155864 CDS NP_289452.1 15803419 960724 3829752..3831209 1 NC_002655.2 transporter 3831209 ygfO 960724 ygfO Escherichia coli O157:H7 str. EDL933 transporter NP_289452.1 3829752 D 155864 CDS NP_289453.1 15803420 958367 3831224..3832543 1 NC_002655.2 Catalyzes the deamination of guanine; guanine deaminase 3832543 ygfP 958367 ygfP Escherichia coli O157:H7 str. EDL933 guanine deaminase NP_289453.1 3831224 D 155864 CDS NP_289454.1 15803421 958369 3832579..3833946 1 NC_002655.2 hypothetical protein 3833946 958369 Z4223 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289454.1 3832579 D 155864 CDS NP_289455.1 15803422 958373 complement(3833982..3834377) 1 NC_002655.2 oxidoreductase, Fe-S subunit 3834377 ygfS 958373 ygfS Escherichia coli O157:H7 str. EDL933 oxidoreductase, Fe-S subunit NP_289455.1 3833982 R 155864 CDS NP_289456.1 15803423 958357 complement(3834470..3836404) 1 NC_002655.2 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); oxidoreductase Fe-S binding subunit 3836404 ygfT 958357 ygfT Escherichia coli O157:H7 str. EDL933 oxidoreductase Fe-S binding subunit NP_289456.1 3834470 R 155864 CDS NP_289457.1 15803424 958368 3836756..3838273 1 NC_002655.2 permease 3838273 ygfU 958368 ygfU Escherichia coli O157:H7 str. EDL933 permease NP_289457.1 3836756 D 155864 CDS NP_289458.1 15803425 957290 3838523..3839071 1 NC_002655.2 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase 3839071 957290 Z4227 Escherichia coli O157:H7 str. EDL933 isopentenyl-diphosphate delta-isomerase NP_289458.1 3838523 D 155864 CDS NP_289459.1 15803426 958385 complement(3839114..3840631) 1 NC_002655.2 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 3840631 lysS 958385 lysS Escherichia coli O157:H7 str. EDL933 lysyl-tRNA synthetase NP_289459.1 3839114 R 155864 CDS NP_289460.1 15803427 958370 complement(join(3840641..3841663,3841665..3841739)) 1 NC_002655.2 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 3841739 prfB 958370 prfB Escherichia coli O157:H7 str. EDL933 peptide chain release factor 2 NP_289460.1 3840641 R 155864 CDS NP_289461.1 15803428 958389 complement(3841830..3843563) 1 NC_002655.2 5'-3' single-stranded-DNA-specific exonuclease; ssDNA exonuclease RecJ 3843563 recJ 958389 recJ Escherichia coli O157:H7 str. EDL933 ssDNA exonuclease RecJ NP_289461.1 3841830 R 155864 CDS NP_289462.1 15803429 958374 complement(3843569..3844279) 1 NC_002655.2 DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity; thiol:disulfide interchange protein DsbC 3844279 dsbC 958374 dsbC Escherichia coli O157:H7 str. EDL933 thiol:disulfide interchange protein DsbC NP_289462.1 3843569 R 155864 CDS NP_289463.1 15803430 958371 complement(3844304..3845200) 1 NC_002655.2 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 3845200 xerD 958371 xerD Escherichia coli O157:H7 str. EDL933 site-specific tyrosine recombinase XerD NP_289463.1 3844304 R 155864 CDS NP_289464.1 15803431 958365 3845312..3845833 1 NC_002655.2 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic; flavodoxin FldB 3845833 fldB 958365 fldB Escherichia coli O157:H7 str. EDL933 flavodoxin FldB NP_289464.1 3845312 D 155864 CDS NP_289465.1 15803432 958376 complement(3845873..3846280) 1 NC_002655.2 hypothetical protein 3846280 958376 Z4234 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289465.1 3845873 R 155864 CDS NP_289466.1 15803433 958377 complement(3846261..3846527) 1 NC_002655.2 hypothetical protein 3846527 ygfY 958377 ygfY Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289466.1 3846261 R 155864 CDS NP_289467.1 15803434 958375 3846770..3847750 1 NC_002655.2 physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator; global regulator 3847750 ygfZ 958375 ygfZ Escherichia coli O157:H7 str. EDL933 global regulator NP_289467.1 3846770 D 155864 CDS NP_289468.1 15803435 959462 complement(3847827..3848486) 1 NC_002655.2 oxidoreductase 3848486 959462 Z4237 Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_289468.1 3847827 R 155864 CDS NP_289469.1 15803436 961936 complement(3848650..3848961) 1 NC_002655.2 hypothetical protein 3848961 yqfB 961936 yqfB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289469.1 3848650 R 155864 CDS NP_289470.1 15803437 958383 3849000..3850439 1 NC_002655.2 6-phospho-beta-glucosidase 3850439 bglA 958383 bglA Escherichia coli O157:H7 str. EDL933 6-phospho-beta-glucosidase NP_289470.1 3849000 D 155864 CDS NP_289471.1 15803438 961098 complement(3850605..3853478) 1 NC_002655.2 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 3853478 gcvP 961098 gcvP Escherichia coli O157:H7 str. EDL933 glycine dehydrogenase NP_289471.1 3850605 R 155864 CDS NP_289472.1 15803439 960788 complement(3853596..3853985) 1 NC_002655.2 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 3853985 gcvH 960788 gcvH Escherichia coli O157:H7 str. EDL933 glycine cleavage system protein H NP_289472.1 3853596 R 155864 CDS NP_289473.1 15803440 958729 complement(3854009..3855103) 1 NC_002655.2 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 3855103 gcvT 958729 gcvT Escherichia coli O157:H7 str. EDL933 glycine cleavage system aminomethyltransferase T NP_289473.1 3854009 R 155864 CDS NP_289474.1 15803441 958380 complement(3855551..3856753) 1 NC_002655.2 hypothetical protein 3856753 visC 958380 visC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289474.1 3855551 R 155864 CDS NP_289475.1 15803442 959204 complement(3856777..3857955) 1 NC_002655.2 Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone; 2-octaprenyl-6-methoxyphenyl hydroxylase 3857955 ubiH 959204 ubiH Escherichia coli O157:H7 str. EDL933 2-octaprenyl-6-methoxyphenyl hydroxylase NP_289475.1 3856777 R 155864 CDS NP_289476.1 15803443 959337 complement(3857952..3859277) 1 NC_002655.2 exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide; proline aminopeptidase P II 3859277 pepP 959337 pepP Escherichia coli O157:H7 str. EDL933 proline aminopeptidase P II NP_289476.1 3857952 R 155864 CDS NP_289477.2 161367534 958387 complement(3859303..3859881) 1 NC_002655.2 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein 3859881 ygfB 958387 ygfB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289477.2 3859303 R 155864 CDS NP_289478.1 15803445 961267 3860049..3860378 1 NC_002655.2 Z-ring-associated protein 3860378 ygfE 961267 ygfE Escherichia coli O157:H7 str. EDL933 Z-ring-associated protein NP_289478.1 3860049 D 155864 CDS NP_289479.1 15803446 958390 3860678..3861226 1 NC_002655.2 ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function; ligase 3861226 ygfA 958390 ygfA Escherichia coli O157:H7 str. EDL933 ligase NP_289479.1 3860678 D 155864 CDS NP_289481.1 15803448 959584 complement(3862008..3863240) 1 NC_002655.2 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 3863240 serA 959584 serA Escherichia coli O157:H7 str. EDL933 D-3-phosphoglycerate dehydrogenase NP_289481.1 3862008 R 155864 CDS NP_289482.1 15803449 958393 complement(3863495..3864154) 1 NC_002655.2 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 3864154 rpiA 958393 rpiA Escherichia coli O157:H7 str. EDL933 ribose-5-phosphate isomerase A NP_289482.1 3863495 R 155864 CDS NP_289483.1 15803450 957896 3864537..3865430 1 NC_002655.2 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein 3865430 iciA 957896 iciA Escherichia coli O157:H7 str. EDL933 chromosome replication initiation inhibitor protein NP_289483.1 3864537 D 155864 CDS NP_289484.1 15803451 958327 3865634..3867778 1 NC_002655.2 MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 3867778 sbm 958327 sbm Escherichia coli O157:H7 str. EDL933 methylmalonyl-CoA mutase NP_289484.1 3865634 D 155864 CDS NP_289485.1 15803452 958396 3867771..3868766 1 NC_002655.2 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 3868766 ygfD 958396 ygfD Escherichia coli O157:H7 str. EDL933 arginine/ornithine transport system ATPase NP_289485.1 3867771 D 155864 CDS NP_289486.2 161367533 958403 3868777..3869562 1 NC_002655.2 catalyzes the formation of propanoyl-CoA from methylmalonyl-CoA; methylmalonyl-CoA decarboxylase 3869562 ygfG 958403 ygfG Escherichia coli O157:H7 str. EDL933 methylmalonyl-CoA decarboxylase NP_289486.2 3868777 D 155864 CDS NP_289487.1 15803454 958395 3869586..3871064 1 NC_002655.2 coenzyme A transferase 3871064 ygfH 958395 ygfH Escherichia coli O157:H7 str. EDL933 coenzyme A transferase NP_289487.1 3869586 D 155864 CDS NP_289488.1 15803455 958407 complement(3871379..3871957) 1 NC_002655.2 LysR family transcriptional regulator 3871957 958407 Z4258 Escherichia coli O157:H7 str. EDL933 LysR family transcriptional regulator NP_289488.1 3871379 R 155864 CDS NP_289489.1 15803456 958397 complement(3872124..3872864) 1 NC_002655.2 hypothetical protein 3872864 yggE 958397 yggE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289489.1 3872124 R 155864 CDS NP_289490.1 15803457 959537 complement(3872957..3873592) 1 NC_002655.2 Involved in the export of arginine; arginine exporter protein 3873592 yggA 959537 yggA Escherichia coli O157:H7 str. EDL933 arginine exporter protein NP_289490.1 3872957 R 155864 CDS NP_289491.1 15803458 958316 complement(3873731..3874591) 1 NC_002655.2 participates in the regulation of osmotic pressure changes within the cel; mechanosensitive ion channel MscS 3874591 yggB 958316 yggB Escherichia coli O157:H7 str. EDL933 mechanosensitive ion channel MscS NP_289491.1 3873731 R 155864 CDS NP_289492.2 161367532 958398 complement(3874949..3876028) 1 NC_002655.2 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 3876028 fba 958398 fba Escherichia coli O157:H7 str. EDL933 fructose-bisphosphate aldolase NP_289492.2 3874949 R 155864 CDS NP_289493.1 15803460 957143 complement(3876243..3877406) 1 NC_002655.2 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 3877406 pgk 957143 pgk Escherichia coli O157:H7 str. EDL933 phosphoglycerate kinase NP_289493.1 3876243 R 155864 CDS NP_289494.1 15803461 959243 complement(3877456..3878475) 1 NC_002655.2 NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate; erythrose 4-phosphate dehydrogenase 3878475 epd 959243 epd Escherichia coli O157:H7 str. EDL933 erythrose 4-phosphate dehydrogenase NP_289494.1 3877456 R 155864 CDS NP_289495.1 15803462 957101 3878847..3879278 1 NC_002655.2 hypothetical protein 3879278 957101 Z4267 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289495.1 3878847 D 155864 CDS NP_289496.1 15803463 958401 3879301..3879879 1 NC_002655.2 hypothetical protein 3879879 958401 Z4268 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289496.1 3879301 D 155864 CDS NP_289497.1 15803464 958418 3879880..3880587 1 NC_002655.2 hypothetical protein 3880587 958418 Z4269 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289497.1 3879880 D 155864 CDS NP_289498.1 15803465 959364 3880575..3881252 1 NC_002655.2 ABC transporter ATP-binding protein 3881252 959364 Z4270 Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_289498.1 3880575 D 155864 CDS NP_289499.1 15803466 958169 3881213..3881923 1 NC_002655.2 ABC transporter ATP-binding protein 3881923 958169 Z4271 Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_289499.1 3881213 D 155864 CDS NP_289500.1 15803467 958405 complement(3881895..3882608) 1 NC_002655.2 fructose transport system kinase 3882608 frcK 958405 frcK Escherichia coli O157:H7 str. EDL933 fructose transport system kinase NP_289500.1 3881895 R 155864 CDS NP_289501.1 15803468 958338 complement(3882605..3883114) 1 NC_002655.2 DNA-binding transcriptional regulator 3883114 yggD 958338 yggD Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator NP_289501.1 3882605 R 155864 CDS NP_289502.1 15803469 958468 complement(3883136..3884101) 1 NC_002655.2 fructose-1,6-bisphosphatase II-like protein 3884101 yggF 958468 yggF Escherichia coli O157:H7 str. EDL933 fructose-1,6-bisphosphatase II-like protein NP_289502.1 3883136 R 155864 CDS NP_289503.1 15803470 958409 complement(3884098..3885087) 1 NC_002655.2 oxidoreductase 3885087 958409 Z4276 Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_289503.1 3884098 R 155864 CDS NP_289504.1 15803471 958491 complement(3885390..3886778) 1 NC_002655.2 PTS system, mannitol-specific enzyme II component, cryptic 3886778 cmtA 958491 cmtA Escherichia coli O157:H7 str. EDL933 PTS system, mannitol-specific enzyme II component, cryptic NP_289504.1 3885390 R 155864 CDS NP_289505.1 15803472 959538 complement(3886806..3887249) 1 NC_002655.2 TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein; mannitol phosphotransferase subunit EIIA 3887249 cmtB 959538 cmtB Escherichia coli O157:H7 str. EDL933 mannitol phosphotransferase subunit EIIA NP_289505.1 3886806 R 155864 CDS NP_289506.1 15803473 958486 complement(3887563..3889554) 1 NC_002655.2 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 3889554 tktA 958486 tktA Escherichia coli O157:H7 str. EDL933 transketolase NP_289506.1 3887563 R 155864 CDS NP_289507.1 15803474 958413 3889706..3890590 1 NC_002655.2 hypothetical protein 3890590 yggG 958413 yggG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289507.1 3889706 D 155864 CDS NP_289508.1 15803475 958399 complement(3890796..3891716) 1 NC_002655.2 catalyzes the formation of putrescine from agmatine; agmatinase 3891716 speB 958399 speB Escherichia coli O157:H7 str. EDL933 agmatinase NP_289508.1 3890796 R 155864 CDS NP_289509.1 15803476 958414 complement(3891852..3892583) 1 NC_002655.2 No significant matches; hypothetical protein 3892583 958414 Z4282 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289509.1 3891852 R 155864 CDS NP_289510.1 15803477 958416 complement(3892729..3894705) 1 NC_002655.2 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; arginine decarboxylase 3894705 speA 958416 speA Escherichia coli O157:H7 str. EDL933 arginine decarboxylase NP_289510.1 3892729 R 155864 CDS NP_289511.1 15803478 958428 complement(3894714..3894860) 1 NC_002655.2 hypothetical protein 3894860 yqgB 958428 yqgB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289511.1 3894714 R 155864 CDS NP_289512.1 15803479 958430 3894981..3895196 1 NC_002655.2 hypothetical protein 3895196 yqgC 958430 yqgC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289512.1 3894981 D 155864 CDS NP_289513.1 15803480 958432 complement(3895193..3895444) 1 NC_002655.2 hypothetical protein 3895444 yqgD 958432 yqgD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289513.1 3895193 R 155864 CDS NP_289514.1 15803481 958421 3895500..3896654 1 NC_002655.2 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 3896654 metK 958421 metK Escherichia coli O157:H7 str. EDL933 S-adenosylmethionine synthetase NP_289514.1 3895500 D 155864 CDS NP_289515.1 15803482 958406 3897091..3898485 1 NC_002655.2 galactose-proton symport of transport system 3898485 galP 958406 galP Escherichia coli O157:H7 str. EDL933 galactose-proton symport of transport system NP_289515.1 3897091 D 155864 CDS NP_289516.1 15803483 958420 3898562..3899059 1 NC_002655.2 hypothetical protein 3899059 sprT 958420 sprT Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289516.1 3898562 D 155864 CDS NP_289517.1 15803484 958408 3899154..3899861 1 NC_002655.2 DNA-specific endonuclease I 3899861 endA 958408 endA Escherichia coli O157:H7 str. EDL933 DNA-specific endonuclease I NP_289517.1 3899154 D 155864 CDS NP_289518.2 161367531 958425 3899941..3900672 1 NC_002655.2 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 3900672 yggJ 958425 yggJ Escherichia coli O157:H7 str. EDL933 16S ribosomal RNA methyltransferase RsmE NP_289518.2 3899941 D 155864 CDS NP_289519.1 15803486 958424 3900685..3901632 1 NC_002655.2 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 3901632 gshB 958424 gshB Escherichia coli O157:H7 str. EDL933 glutathione synthetase NP_289519.1 3900685 D 155864 CDS NP_289520.2 161367530 959535 3901744..3902307 1 NC_002655.2 hypothetical protein 3902307 yqgE 959535 yqgE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289520.2 3901744 D 155864 CDS NP_289521.1 15803488 958382 3902307..3902723 1 NC_002655.2 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 3902723 yqgF 958382 yqgF Escherichia coli O157:H7 str. EDL933 Holliday junction resolvase-like protein NP_289521.1 3902307 D 155864 CDS NP_289522.1 15803489 958431 complement(3902918..3903943) 1 NC_002655.2 protein transport 3903943 yggR 958431 yggR Escherichia coli O157:H7 str. EDL933 protein transport NP_289522.1 3902918 R 155864 CDS NP_289523.1 15803490 958162 3903916..3904620 1 NC_002655.2 hypothetical protein 3904620 yggS 958162 yggS Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289523.1 3903916 D 155864 CDS NP_289524.1 15803491 957823 3904638..3905204 1 NC_002655.2 resistance protein 3905204 yggT 957823 yggT Escherichia coli O157:H7 str. EDL933 resistance protein NP_289524.1 3904638 D 155864 CDS NP_289525.2 161367529 958419 3905201..3905491 1 NC_002655.2 hypothetical protein 3905491 yggU 958419 yggU Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289525.2 3905201 D 155864 CDS NP_289526.1 15803493 958435 3905499..3906092 1 NC_002655.2 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 3906092 yggV 958435 yggV Escherichia coli O157:H7 str. EDL933 deoxyribonucleotide triphosphate pyrophosphatase NP_289526.1 3905499 D 155864 CDS NP_289527.1 15803494 958219 3906085..3907221 1 NC_002655.2 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 3907221 yggW 958219 yggW Escherichia coli O157:H7 str. EDL933 coproporphyrinogen III oxidase NP_289527.1 3906085 D 155864 CDS NP_289528.1 15803495 958436 complement(3907464..3908471) 1 NC_002655.2 alpha helix chain 3908471 yggM 958436 yggM Escherichia coli O157:H7 str. EDL933 alpha helix chain NP_289528.1 3907464 R 155864 CDS NP_289529.1 15803496 961194 complement(3908588..3909634) 1 NC_002655.2 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II 3909634 ansB 961194 ansB Escherichia coli O157:H7 str. EDL933 L-asparaginase II NP_289529.1 3908588 R 155864 CDS NP_289530.1 15803497 961166 complement(3909810..3910529) 1 NC_002655.2 hypothetical protein 3910529 yggN 961166 yggN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289530.1 3909810 R 155864 CDS NP_289531.2 161367528 958438 complement(3910713..3911039) 1 NC_002655.2 hypothetical protein 3911039 yggL 958438 yggL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289531.2 3910713 R 155864 CDS NP_289532.1 15803499 958423 complement(3911039..3911758) 1 NC_002655.2 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 3911758 trmB 958423 trmB Escherichia coli O157:H7 str. EDL933 tRNA (guanine-N(7)-)-methyltransferase NP_289532.1 3911039 R 155864 CDS NP_289533.1 15803500 958446 3911919..3912971 1 NC_002655.2 adenine DNA glycosylase 3912971 mutY 958446 mutY Escherichia coli O157:H7 str. EDL933 adenine DNA glycosylase NP_289533.1 3911919 D 155864 CDS NP_289534.1 15803501 958439 3912999..3913274 1 NC_002655.2 hypothetical protein 3913274 yggX 958439 yggX Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289534.1 3912999 D 155864 CDS NP_289535.1 15803502 958440 3913336..3914418 1 NC_002655.2 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C 3914418 mltC 958440 mltC Escherichia coli O157:H7 str. EDL933 murein transglycosylase C NP_289535.1 3913336 D 155864 CDS NP_289536.1 15803503 958452 3914572..3915876 1 NC_002655.2 transport of nucleosides, permease 3915876 nupG 958452 nupG Escherichia coli O157:H7 str. EDL933 transport of nucleosides, permease NP_289536.1 3914572 D 155864 CDS NP_289537.1 15803504 958455 complement(3915926..3918121) 1 NC_002655.2 ornithine decarboxylase 3918121 speC 958455 speC Escherichia coli O157:H7 str. EDL933 ornithine decarboxylase NP_289537.1 3915926 R 155864 CDS NP_289538.1 15803505 958442 3918459..3919166 1 NC_002655.2 transporter 3919166 yqgA 958442 yqgA Escherichia coli O157:H7 str. EDL933 transporter NP_289538.1 3918459 D 155864 CDS NP_289539.1 15803506 956707 3919545..3920810 1 NC_002655.2 pathogenicity island integrase 3920810 956707 Z4313 Escherichia coli O157:H7 str. EDL933 pathogenicity island integrase NP_289539.1 3919545 D 155864 CDS NP_289540.2 157267370 957179 complement(3920927..3921712) 1 NC_002655.2 hypothetical protein 3921712 957179 Z4314 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289540.2 3920927 R 155864 CDS NP_289541.1 15803508 958449 3921801..3922475 1 NC_002655.2 hypothetical protein 3922475 958449 Z4315 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289541.1 3921801 D 155864 CDS NP_289542.1 15803509 958456 3922472..3922819 1 NC_002655.2 hypothetical protein 3922819 958456 Z4316 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289542.1 3922472 D 155864 CDS NP_289543.1 15803510 958460 3922839..3924287 1 NC_002655.2 hypothetical protein 3924287 958460 Z4317 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289543.1 3922839 D 155864 CDS NP_289544.1 15803511 958457 complement(3924088..3925032) 1 NC_002655.2 hypothetical protein 3925032 958457 Z4318 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289544.1 3924088 R 155864 CDS NP_289545.1 15803512 958451 3924862..3924936 1 NC_002655.2 No significant matches; hypothetical protein 3924936 958451 Z4320 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289545.1 3924862 D 155864 CDS NP_289546.1 15803513 961193 complement(3925141..3925674) 1 NC_002655.2 PagC-like membrane protein 3925674 961193 Z4321 Escherichia coli O157:H7 str. EDL933 PagC-like membrane protein NP_289546.1 3925141 R 155864 CDS NP_289547.1 15803514 958426 complement(3926262..3926462) 1 NC_002655.2 No significant matches; hypothetical protein 3926462 958426 Z4322 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289547.1 3926262 R 155864 CDS NP_289548.1 15803515 958341 complement(3926749..3927303) 1 NC_002655.2 No significant matches; hypothetical protein 3927303 958341 Z4323 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289548.1 3926749 R 155864 CDS NP_289549.1 15803516 958453 3927142..3927882 1 NC_002655.2 transposase 3927882 958453 Z4324 Escherichia coli O157:H7 str. EDL933 transposase NP_289549.1 3927142 D 155864 CDS NP_289550.1 15803517 958417 3928356..3928526 1 NC_002655.2 No significant matches; hypothetical protein 3928526 958417 Z4325 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289550.1 3928356 D 155864 CDS NP_289551.1 15803518 956950 3928670..3930319 1 NC_002655.2 enterotoxin 3930319 956950 Z4326 Escherichia coli O157:H7 str. EDL933 enterotoxin NP_289551.1 3928670 D 155864 CDS NP_289553.1 15803520 958461 3930927..3931916 1 NC_002655.2 hypothetical protein 3931916 958461 Z4328 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289553.1 3930927 D 155864 CDS NP_289554.1 15803521 958464 3931965..3932639 1 NC_002655.2 No significant matches; hypothetical protein 3932639 958464 Z4329 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289554.1 3931965 D 155864 CDS NP_289555.1 15803522 958465 3933017..3933862 1 NC_002655.2 transposase 3933862 958465 Z4330 Escherichia coli O157:H7 str. EDL933 transposase NP_289555.1 3933017 D 155864 CDS NP_289557.1 15803524 956959 3934514..3935815 1 NC_002655.2 cytotoxin 3935815 956959 Z4332 Escherichia coli O157:H7 str. EDL933 cytotoxin NP_289557.1 3934514 D 155864 CDS NP_289558.1 15803525 958282 3935821..3936648 1 NC_002655.2 cytotoxin 3936648 958282 Z4333 Escherichia coli O157:H7 str. EDL933 cytotoxin NP_289558.1 3935821 D 155864 CDS NP_289559.1 15803526 958459 complement(3936688..3937335) 1 NC_002655.2 IS629 transposase 3937335 958459 Z4334 Escherichia coli O157:H7 str. EDL933 IS629 transposase NP_289559.1 3936688 R 155864 CDS NP_289560.1 15803527 957274 complement(3937575..3937901) 1 NC_002655.2 hypothetical protein 3937901 957274 Z4335 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289560.1 3937575 R 155864 CDS NP_289561.1 15803528 957180 3938092..3938439 1 NC_002655.2 hypothetical protein 3938439 957180 Z4336 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289561.1 3938092 D 155864 CDS NP_289562.1 15803529 959251 3938489..3940027 1 NC_002655.2 hypothetical protein 3940027 959251 Z4337 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289562.1 3938489 D 155864 CDS NP_289563.1 15803530 958462 3940250..3940600 1 NC_002655.2 hypothetical protein 3940600 958462 Z4338 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289563.1 3940250 D 155864 CDS NP_289564.1 15803531 958467 3940813..3942216 1 NC_002655.2 hypothetical protein 3942216 958467 Z4340 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289564.1 3940813 D 155864 CDS NP_289565.1 15803532 958466 complement(3942722..3944038) 1 NC_002655.2 transporter 3944038 pitB 958466 pitB Escherichia coli O157:H7 str. EDL933 transporter NP_289565.1 3942722 R 155864 CDS NP_289566.1 15803533 958472 complement(3944330..3946189) 1 NC_002655.2 catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction; bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase 3946189 gsp 958472 gsp Escherichia coli O157:H7 str. EDL933 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase NP_289566.1 3944330 R 155864 CDS NP_289567.1 15803534 958471 3946346..3947260 1 NC_002655.2 YghU; B2989; one of eight glutathione transferases from E. coli; glutathione S-transferase 3947260 958471 Z4343 Escherichia coli O157:H7 str. EDL933 glutathione S-transferase NP_289567.1 3946346 D 155864 CDS NP_289568.1 15803535 958474 complement(3947383..3947631) 1 NC_002655.2 hydrogenase 2 accessory protein HypG 3947631 hybG 958474 hybG Escherichia coli O157:H7 str. EDL933 hydrogenase 2 accessory protein HypG NP_289568.1 3947383 R 155864 CDS NP_289569.1 15803536 958485 complement(3947644..3947985) 1 NC_002655.2 plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein HybF 3947985 hypA 958485 hypA Escherichia coli O157:H7 str. EDL933 hydrogenase nickel incorporation protein HybF NP_289569.1 3947644 R 155864 CDS NP_289570.1 15803537 958475 complement(3947978..3948466) 1 NC_002655.2 hydrogenase 2-specific chaperone 3948466 hybE 958475 hybE Escherichia coli O157:H7 str. EDL933 hydrogenase 2-specific chaperone NP_289570.1 3947978 R 155864 CDS NP_289571.1 15803538 958483 complement(3948459..3948953) 1 NC_002655.2 protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); hydrogenase 2 maturation endopeptidase 3948953 hybD 958483 hybD Escherichia coli O157:H7 str. EDL933 hydrogenase 2 maturation endopeptidase NP_289571.1 3948459 R 155864 CDS NP_289572.1 15803539 958476 complement(3948953..3950656) 1 NC_002655.2 involved in hydrogen uptake; hydrogenase 2 large subunit 3950656 hybC 958476 hybC Escherichia coli O157:H7 str. EDL933 hydrogenase 2 large subunit NP_289572.1 3948953 R 155864 CDS NP_289573.1 15803540 958480 complement(3950653..3951831) 1 NC_002655.2 HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits; hydrogenase 2 b cytochrome subunit 3951831 hybB 958480 hybB Escherichia coli O157:H7 str. EDL933 hydrogenase 2 b cytochrome subunit NP_289573.1 3950653 R 155864 CDS NP_289574.1 15803541 958469 complement(3951821..3952807) 1 NC_002655.2 Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; hydrogenase 2 protein HybA 3952807 hybA 958469 hybA Escherichia coli O157:H7 str. EDL933 hydrogenase 2 protein HybA NP_289574.1 3951821 R 155864 CDS NP_289575.1 15803542 958478 complement(3952810..3953928) 1 NC_002655.2 involved in hydrogen uptake; hydrogenase 2 small subunit 3953928 958478 Z4351 Escherichia coli O157:H7 str. EDL933 hydrogenase 2 small subunit NP_289575.1 3952810 R 155864 CDS NP_289576.1 15803543 958320 complement(3954117..3954404) 1 NC_002655.2 hypothetical protein 3954404 958320 Z4352 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289576.1 3954117 R 155864 CDS NP_289577.1 15803544 958477 complement(3954523..3955449) 1 NC_002655.2 hypothetical protein 3955449 958477 Z4353 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289577.1 3954523 R 155864 CDS NP_289578.1 15803545 958479 3955567..3956607 1 NC_002655.2 aldo/keto reductase 3956607 958479 Z4354 Escherichia coli O157:H7 str. EDL933 aldo/keto reductase NP_289578.1 3955567 D 155864 CDS NP_289579.1 15803546 957436 complement(3956647..3957141) 1 NC_002655.2 hypothetical protein 3957141 yqhA 957436 yqhA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289579.1 3956647 R 155864 CDS NP_289580.1 15803547 961274 3957332..3958216 1 NC_002655.2 oxidoreductase 3958216 yghA 961274 yghA Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_289580.1 3957332 D 155864 CDS NP_289581.1 15803548 961277 3958392..3958637 1 NC_002655.2 hypothetical protein 3958637 961277 Z4357 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289581.1 3958392 D 155864 CDS NP_289582.1 15803549 958487 complement(3958488..3958913) 1 NC_002655.2 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbD 3958913 exbD 958487 exbD Escherichia coli O157:H7 str. EDL933 biopolymer transport protein ExbD NP_289582.1 3958488 R 155864 CDS NP_289583.1 15803550 959561 complement(3958920..3959654) 1 NC_002655.2 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbB 3959654 exbB 959561 exbB Escherichia coli O157:H7 str. EDL933 biopolymer transport protein ExbB NP_289583.1 3958920 R 155864 CDS NP_289584.1 15803551 961969 complement(3959647..3959802) 1 NC_002655.2 hypothetical protein 3959802 961969 Z4360 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289584.1 3959647 R 155864 CDS NP_289585.1 15803552 958488 3959906..3961093 1 NC_002655.2 catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 3961093 metC 958488 metC Escherichia coli O157:H7 str. EDL933 cystathionine beta-lyase NP_289585.1 3959906 D 155864 CDS NP_289586.1 15803553 961339 3961233..3961892 1 NC_002655.2 hypothetical protein 3961892 yghB 961339 yghB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289586.1 3961233 D 155864 CDS NP_289587.1 15803554 961329 complement(3961932..3963059) 1 NC_002655.2 AraC family transcriptional regulator 3963059 yqhC 961329 yqhC Escherichia coli O157:H7 str. EDL933 AraC family transcriptional regulator NP_289587.1 3961932 R 155864 CDS NP_289588.1 15803555 959332 3963025..3964188 1 NC_002655.2 oxidoreductase 3964188 yqhD 959332 yqhD Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_289588.1 3963025 D 155864 CDS NP_289589.2 161367527 957304 3964293..3965120 1 NC_002655.2 methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate; 2,5-diketo-D-gluconate reductase A 3965120 dkgA 957304 dkgA Escherichia coli O157:H7 str. EDL933 2,5-diketo-D-gluconate reductase A NP_289589.2 3964293 D 155864 CDS NP_289590.1 15803557 958492 3965321..3965596 1 NC_002655.2 hypothetical protein 3965596 958492 Z4367 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289590.1 3965321 D 155864 CDS NP_289591.2 157267371 958494 3965590..3966243 1 NC_002655.2 hypothetical protein 3966243 yqhG 958494 yqhG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289591.2 3965590 D 155864 CDS NP_289592.1 15803559 958495 3966292..3966549 1 NC_002655.2 outer membrane lipoprotein 3966549 yqhH 958495 yqhH Escherichia coli O157:H7 str. EDL933 outer membrane lipoprotein NP_289592.1 3966292 D 155864 CDS NP_289593.1 15803560 958500 complement(3966592..3968811) 1 NC_002655.2 hypothetical protein 3968811 958500 Z4370 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289593.1 3966592 R 155864 CDS NP_289594.1 15803561 958496 complement(3968922..3970334) 1 NC_002655.2 repressor protein for FtsI 3970334 sufI 958496 sufI Escherichia coli O157:H7 str. EDL933 repressor protein for FtsI NP_289594.1 3968922 R 155864 CDS NP_289595.1 15803562 958493 complement(3970409..3971146) 1 NC_002655.2 1-acyl-sn-glycerol-3-phosphate acyltransferase 3971146 plsC 958493 plsC Escherichia coli O157:H7 str. EDL933 1-acyl-sn-glycerol-3-phosphate acyltransferase NP_289595.1 3970409 R 155864 CDS NP_289596.1 15803563 958400 complement(3971380..3973638) 1 NC_002655.2 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 3973638 parC 958400 parC Escherichia coli O157:H7 str. EDL933 DNA topoisomerase IV subunit A NP_289596.1 3971380 R 155864 CDS NP_289597.1 15803564 958499 complement(3973776..3975383) 1 NC_002655.2 YgiS; uncharacterized periplasmic protein that seems to be part of a binding-protein-dependent transport system; hypothetical protein 3975383 958499 Z4374 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289597.1 3973776 R 155864 CDS NP_289598.1 15803565 958702 complement(3975492..3975974) 1 NC_002655.2 hypothetical protein 3975974 958702 Z4375 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289598.1 3975492 R 155864 CDS NP_289599.1 15803566 958347 complement(3976027..3976419) 1 NC_002655.2 hypothetical protein 3976419 ygiW 958347 ygiW Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289599.1 3976027 R 155864 CDS NP_289600.1 15803567 958498 3976571..3977230 1 NC_002655.2 QseB; response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes; DNA-binding transcriptional regulator QseB 3977230 qseB 958498 qseB Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator QseB NP_289600.1 3976571 D 155864 CDS NP_289601.1 15803568 958502 3977227..3978576 1 NC_002655.2 QseC; sensor protein QseC 3978576 qseC 958502 qseC Escherichia coli O157:H7 str. EDL933 sensor protein QseC NP_289601.1 3977227 D 155864 CDS NP_289602.1 15803569 958510 3978686..3979267 1 NC_002655.2 modulator of drug activity B 3979267 mdaB 958510 mdaB Escherichia coli O157:H7 str. EDL933 modulator of drug activity B NP_289602.1 3978686 D 155864 CDS NP_289603.1 15803570 958514 3979298..3979612 1 NC_002655.2 hypothetical protein 3979612 ygiN 958514 ygiN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289603.1 3979298 D 155864 CDS NP_289604.1 15803571 956887 complement(3979657..3980544) 1 NC_002655.2 hypothetical protein 3980544 956887 Z4381 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289604.1 3979657 R 155864 CDS NP_289605.1 15803572 959283 complement(3980541..3981488) 1 NC_002655.2 iron ABC transporter substrate-binding protein 3981488 959283 Z4382 Escherichia coli O157:H7 str. EDL933 iron ABC transporter substrate-binding protein NP_289605.1 3980541 R 155864 CDS NP_289606.1 15803573 958504 complement(3981499..3982548) 1 NC_002655.2 iron ABC transporter permease 3982548 958504 Z4383 Escherichia coli O157:H7 str. EDL933 iron ABC transporter permease NP_289606.1 3981499 R 155864 CDS NP_289607.1 15803574 958513 complement(3982545..3983528) 1 NC_002655.2 iron ABC transporter permease 3983528 958513 Z4384 Escherichia coli O157:H7 str. EDL933 iron ABC transporter permease NP_289607.1 3982545 R 155864 CDS NP_289608.1 15803575 958505 complement(3983525..3984334) 1 NC_002655.2 ABC transporter ATP-binding protein 3984334 958505 Z4385 Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_289608.1 3983525 R 155864 CDS NP_289609.1 15803576 958501 3984708..3986849 1 NC_002655.2 iron compound receptor 3986849 958501 Z4386 Escherichia coli O157:H7 str. EDL933 iron compound receptor NP_289609.1 3984708 D 155864 CDS NP_289610.1 15803577 958226 complement(3986913..3988805) 1 NC_002655.2 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 3988805 parE 958226 parE Escherichia coli O157:H7 str. EDL933 DNA topoisomerase IV subunit B NP_289610.1 3986913 R 155864 CDS NP_289611.1 15803578 958506 complement(3988834..3989415) 1 NC_002655.2 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase 3989415 yqiA 958506 yqiA Escherichia coli O157:H7 str. EDL933 esterase NP_289611.1 3988834 R 155864 CDS NP_289612.1 15803579 958507 complement(3989415..3990242) 1 NC_002655.2 cyclic 3',5'-adenosine monophosphate phosphodiesterase 3990242 icc 958507 icc Escherichia coli O157:H7 str. EDL933 cyclic 3',5'-adenosine monophosphate phosphodiesterase NP_289612.1 3989415 R 155864 CDS NP_289613.1 15803580 959516 complement(3990267..3990689) 1 NC_002655.2 hypothetical protein 3990689 yqiB 959516 yqiB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289613.1 3990267 R 155864 CDS NP_289614.1 15803581 961965 complement(3990690..3991319) 1 NC_002655.2 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose pyrophosphatase 3991319 nudF 961965 nudF Escherichia coli O157:H7 str. EDL933 ADP-ribose pyrophosphatase NP_289614.1 3990690 R 155864 CDS NP_289615.2 161367526 958511 3991524..3993005 1 NC_002655.2 trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell; outer membrane channel protein 3993005 tolC 958511 tolC Escherichia coli O157:H7 str. EDL933 outer membrane channel protein NP_289615.2 3991524 D 155864 CDS NP_289616.1 15803583 958512 3993005..3993265 1 NC_002655.2 hypothetical protein 3993265 ygiA 958512 ygiA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289616.1 3993005 D 155864 CDS NP_289617.2 161367525 959515 3993153..3993824 1 NC_002655.2 hypothetical protein 3993824 ygiB 959515 ygiB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289617.2 3993153 D 155864 CDS NP_289618.1 15803585 961964 3993830..3994990 1 NC_002655.2 synthetase/amidase 3994990 ygiC 961964 ygiC Escherichia coli O157:H7 str. EDL933 synthetase/amidase NP_289618.1 3993830 D 155864 CDS NP_289619.1 15803586 958515 complement(3995028..3995843) 1 NC_002655.2 seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine; hypothetical protein 3995843 ygiD 958515 ygiD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289619.1 3995028 R 155864 CDS NP_289620.1 15803587 958516 3995959..3996732 1 NC_002655.2 zinc transporter ZupT 3996732 ygiE 958516 ygiE Escherichia coli O157:H7 str. EDL933 zinc transporter ZupT NP_289620.1 3995959 D 155864 CDS NP_289621.1 15803588 961335 complement(3996790..3996960) 1 NC_002655.2 No significant matches; hypothetical protein 3996960 961335 Z4398 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289621.1 3996790 R 155864 CDS NP_289622.1 15803589 961299 complement(3997222..3997875) 1 NC_002655.2 DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase 3997875 ribB 961299 ribB Escherichia coli O157:H7 str. EDL933 3,4-dihydroxy-2-butanone 4-phosphate synthase NP_289622.1 3997222 R 155864 CDS NP_289623.1 15803590 961425 3998213..3998548 1 NC_002655.2 hypothetical protein 3998548 961425 Z4400 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289623.1 3998213 D 155864 CDS NP_289624.1 15803591 959514 complement(3998583..3998789) 1 NC_002655.2 Involved in glycogen synthesis. May be involved in glycogen priming; glycogen synthesis protein GlgS 3998789 glgS 959514 glgS Escherichia coli O157:H7 str. EDL933 glycogen synthesis protein GlgS NP_289624.1 3998583 R 155864 CDS NP_289625.1 15803592 961963 3999052..3999666 1 NC_002655.2 oxidoreductase 3999666 961963 Z4402 Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_289625.1 3999052 D 155864 CDS NP_289626.1 15803593 958520 3999708..4001369 1 NC_002655.2 hypothetical protein 4001369 958520 Z4403 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289626.1 3999708 D 155864 CDS NP_289627.1 15803594 958521 complement(4002163..4003596) 1 NC_002655.2 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase 4003596 958521 Z4405 Escherichia coli O157:H7 str. EDL933 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase NP_289627.1 4002163 R 155864 CDS NP_289628.1 15803595 959563 complement(4003644..4006484) 1 NC_002655.2 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 4006484 glnE 959563 glnE Escherichia coli O157:H7 str. EDL933 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase NP_289628.1 4003644 R 155864 CDS NP_289629.1 15803596 958526 complement(4006507..4007808) 1 NC_002655.2 hypothetical protein 4007808 ygiF 958526 ygiF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289629.1 4006507 R 155864 CDS NP_289630.1 15803597 958527 4008050..4008670 1 NC_002655.2 signal transduction protein 4008670 ygiM 958527 ygiM Escherichia coli O157:H7 str. EDL933 signal transduction protein NP_289630.1 4008050 D 155864 CDS NP_289631.1 15803598 958528 4008734..4009972 1 NC_002655.2 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 4009972 cca 958528 cca Escherichia coli O157:H7 str. EDL933 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase NP_289631.1 4008734 D 155864 CDS NP_289632.1 15803599 958529 complement(4010153..4010974) 1 NC_002655.2 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase 4010974 uppP 958529 uppP Escherichia coli O157:H7 str. EDL933 undecaprenyl pyrophosphate phosphatase NP_289632.1 4010153 R 155864 CDS NP_289633.1 15803600 958519 complement(4011065..4011436) 1 NC_002655.2 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin; bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase 4011436 folB 958519 folB Escherichia coli O157:H7 str. EDL933 bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase NP_289633.1 4011065 R 155864 CDS NP_289634.1 15803601 959565 4011539..4012156 1 NC_002655.2 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY 4012156 ygiH 959565 ygiH Escherichia coli O157:H7 str. EDL933 glycerol-3-phosphate acyltransferase PlsY NP_289634.1 4011539 D 155864 CDS NP_289635.1 15803602 961971 complement(4012169..4013101) 1 NC_002655.2 activates expression of genes required for L-tartrate-dependent anaerobic growth on glycerol; transcriptional activator TtdR 4013101 ygiP 961971 ygiP Escherichia coli O157:H7 str. EDL933 transcriptional activator TtdR NP_289635.1 4012169 R 155864 CDS NP_289636.1 15803603 958530 4013308..4014219 1 NC_002655.2 Involved in the tartrate degradation pathway; tartrate dehydratase subunit alpha 4014219 ttdA 958530 ttdA Escherichia coli O157:H7 str. EDL933 tartrate dehydratase subunit alpha NP_289636.1 4013308 D 155864 CDS NP_289637.1 15803604 958372 4014216..4014821 1 NC_002655.2 Involved in the tartrate degradation pathway; L(+)-tartrate dehydratase subunit beta 4014821 ttdB 958372 ttdB Escherichia coli O157:H7 str. EDL933 L(+)-tartrate dehydratase subunit beta NP_289637.1 4014216 D 155864 CDS NP_289638.1 15803605 961221 4014870..4016333 1 NC_002655.2 hypothetical protein 4016333 ygjE 961221 ygjE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289638.1 4014870 D 155864 CDS NP_289639.1 15803606 959257 complement(4016376..4017389) 1 NC_002655.2 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 4017389 ygjD 959257 ygjD Escherichia coli O157:H7 str. EDL933 DNA-binding/iron metalloprotein/AP endonuclease NP_289639.1 4016376 R 155864 CDS NP_289640.1 15803607 958532 4017627..4017842 1 NC_002655.2 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 4017842 rpsU 958532 rpsU Escherichia coli O157:H7 str. EDL933 30S ribosomal protein S21 NP_289640.1 4017627 D 155864 CDS NP_289641.1 15803608 958533 4017953..4019698 1 NC_002655.2 synthesizes RNA primers at the replication forks; DNA primase 4019698 dnaG 958533 dnaG Escherichia coli O157:H7 str. EDL933 DNA primase NP_289641.1 4017953 D 155864 CDS NP_289642.1 15803609 958534 4019893..4021734 1 NC_002655.2 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 4021734 rpoD 958534 rpoD Escherichia coli O157:H7 str. EDL933 RNA polymerase sigma factor RpoD NP_289642.1 4019893 D 155864 CDS NP_289643.1 15803610 958536 complement(4021813..4022319) 1 NC_002655.2 G/U mismatch-specific DNA glycosylase 4022319 ygjF 958536 ygjF Escherichia coli O157:H7 str. EDL933 G/U mismatch-specific DNA glycosylase NP_289643.1 4021813 R 155864 CDS NP_289644.1 15803611 958551 complement(4022573..4023337) 1 NC_002655.2 hypothetical protein 4023337 yqjH 958551 yqjH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289644.1 4022573 R 155864 CDS NP_289645.1 15803612 960239 4023625..4024248 1 NC_002655.2 hypothetical protein 4024248 yqjI 960239 yqjI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289645.1 4023625 D 155864 CDS NP_289646.1 15803613 958561 complement(4024402..4025922) 1 NC_002655.2 aerotaxis sensor receptor, flavoprotein 4025922 aer 958561 aer Escherichia coli O157:H7 str. EDL933 aerotaxis sensor receptor, flavoprotein NP_289646.1 4024402 R 155864 CDS NP_289647.2 161367524 958552 4026313..4027719 1 NC_002655.2 catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate; putrescine--2-oxoglutarate aminotransferase 4027719 ygjG 958552 ygjG Escherichia coli O157:H7 str. EDL933 putrescine--2-oxoglutarate aminotransferase NP_289647.2 4026313 D 155864 CDS NP_289648.1 15803615 961517 complement(4027761..4028093) 1 NC_002655.2 hypothetical protein 4028093 ygjH 961517 ygjH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289648.1 4027761 R 155864 CDS NP_289649.1 15803616 958572 4028312..4029295 1 NC_002655.2 DNA-binding transcriptional repressor EbgR 4029295 ebgR 958572 ebgR Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional repressor EbgR NP_289649.1 4028312 D 155864 CDS NP_289650.2 161367523 961444 4029479..4032571 1 NC_002655.2 in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit alpha 4032571 ebgA 961444 ebgA Escherichia coli O157:H7 str. EDL933 cryptic beta-D-galactosidase subunit alpha NP_289650.2 4029479 D 155864 CDS NP_289651.1 15803618 958555 4032568..4033017 1 NC_002655.2 in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit beta 4033017 ebgC 958555 ebgC Escherichia coli O157:H7 str. EDL933 cryptic beta-D-galactosidase subunit beta NP_289651.1 4032568 D 155864 CDS NP_289652.1 15803619 958556 4033080..4034513 1 NC_002655.2 oxidoreductase 4034513 ygjI 958556 ygjI Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_289652.1 4033080 D 155864 CDS NP_289653.1 15803620 960426 4034647..4035717 1 NC_002655.2 hypothetical protein 4035717 ygjJ 960426 ygjJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289653.1 4034647 D 155864 CDS NP_289654.1 15803621 958786 4035734..4038085 1 NC_002655.2 glycosyl hydrolase 4038085 ygjK 958786 ygjK Escherichia coli O157:H7 str. EDL933 glycosyl hydrolase NP_289654.1 4035734 D 155864 CDS NP_289655.1 15803622 960277 4038511..4040529 1 NC_002655.2 NADPH dehydrogenase 4040529 ygjL 960277 ygjL Escherichia coli O157:H7 str. EDL933 NADPH dehydrogenase NP_289655.1 4038511 D 155864 CDS NP_289656.1 15803623 956720 complement(4040574..4040990) 1 NC_002655.2 hypothetical protein 4040990 ygjM 956720 ygjM Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289656.1 4040574 R 155864 CDS NP_289657.1 15803624 958558 complement(4040987..4041301) 1 NC_002655.2 hypothetical protein 4041301 ygjN 958558 ygjN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289657.1 4040987 R 155864 CDS NP_289658.1 15803625 959810 complement(4041585..4042721) 1 NC_002655.2 hypothetical protein 4042721 ygjO 959810 ygjO Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289658.1 4041585 R 155864 CDS NP_289659.1 15803626 960962 4042770..4043309 1 NC_002655.2 hypothetical protein 4043309 ygjP 960962 ygjP Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289659.1 4042770 D 155864 CDS NP_289660.1 15803627 958559 4043386..4044078 1 NC_002655.2 hypothetical protein 4044078 ygjQ 958559 ygjQ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289660.1 4043386 D 155864 CDS NP_289661.1 15803628 958059 4044139..4045143 1 NC_002655.2 hypothetical protein 4045143 ygjR 958059 ygjR Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289661.1 4044139 D 155864 CDS NP_289662.1 15803629 960979 4045427..4046392 1 NC_002655.2 transporter 4046392 ygjT 960979 ygjT Escherichia coli O157:H7 str. EDL933 transporter NP_289662.1 4045427 D 155864 CDS NP_289663.1 15803630 958142 4046791..4048035 1 NC_002655.2 involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 4048035 ygjU 958142 ygjU Escherichia coli O157:H7 str. EDL933 serine/threonine transporter SstT NP_289663.1 4046791 D 155864 CDS NP_289664.1 15803631 958560 complement(4048040..4048591) 1 NC_002655.2 hypothetical protein 4048591 ygjV 958560 ygjV Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289664.1 4048040 R 155864 CDS NP_289665.1 15803632 958562 complement(4048674..4050161) 1 NC_002655.2 altronate hydrolase 4050161 uxaA 958562 uxaA Escherichia coli O157:H7 str. EDL933 altronate hydrolase NP_289665.1 4048674 R 155864 CDS NP_289666.1 15803633 961442 complement(4050176..4051588) 1 NC_002655.2 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism; glucuronate isomerase 4051588 uxaC 961442 uxaC Escherichia coli O157:H7 str. EDL933 glucuronate isomerase NP_289666.1 4050176 R 155864 CDS NP_289667.1 15803634 958081 4051952..4053370 1 NC_002655.2 transport of hexuronates 4053370 exuT 958081 exuT Escherichia coli O157:H7 str. EDL933 transport of hexuronates NP_289667.1 4051952 D 155864 CDS NP_289668.2 161367522 958563 4053500..4054276 1 NC_002655.2 regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.; DNA-binding transcriptional repressor ExuR 4054276 exuR 958563 exuR Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional repressor ExuR NP_289668.2 4053500 D 155864 CDS NP_289669.1 15803636 958564 4054621..4055283 1 NC_002655.2 hypothetical protein 4055283 yqjA 958564 yqjA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289669.1 4054621 D 155864 CDS NP_289670.1 15803637 958568 4055287..4055670 1 NC_002655.2 hypothetical protein 4055670 yqjB 958568 yqjB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289670.1 4055287 D 155864 CDS NP_289671.2 228979045 958569 4055817..4056185 1 NC_002655.2 hypothetical protein 4056185 yqjC 958569 yqjC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289671.2 4055817 D 155864 CDS NP_289672.1 15803639 958574 4056223..4056528 1 NC_002655.2 hypothetical protein 4056528 yqjD 958574 yqjD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289672.1 4056223 D 155864 CDS NP_289673.1 15803640 958571 4056531..4056935 1 NC_002655.2 hypothetical protein 4056935 yqjE 958571 yqjE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289673.1 4056531 D 155864 CDS NP_289674.1 15803641 958576 4056925..4057224 1 NC_002655.2 hypothetical protein 4057224 958576 Z4454 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289674.1 4056925 D 155864 CDS NP_289675.1 15803642 958578 4057320..4057802 1 NC_002655.2 hypothetical protein 4057802 yqjF 958578 yqjF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289675.1 4057320 D 155864 CDS NP_289676.1 15803643 958580 4057872..4058858 1 NC_002655.2 transferase 4058858 yqjG 958580 yqjG Escherichia coli O157:H7 str. EDL933 transferase NP_289676.1 4057872 D 155864 CDS NP_289677.1 15803644 957366 4059150..4059515 1 NC_002655.2 cytochrome 4059515 yhaH 957366 yhaH Escherichia coli O157:H7 str. EDL933 cytochrome NP_289677.1 4059150 D 155864 CDS NP_289678.1 15803645 958063 4059756..4060112 1 NC_002655.2 cytochrome 4060112 yhaI 958063 yhaI Escherichia coli O157:H7 str. EDL933 cytochrome NP_289678.1 4059756 D 155864 CDS NP_289679.1 15803646 958076 complement(4060163..4061059) 1 NC_002655.2 LysR family transcriptional regulator 4061059 yhaJ 958076 yhaJ Escherichia coli O157:H7 str. EDL933 LysR family transcriptional regulator NP_289679.1 4060163 R 155864 CDS NP_289680.1 15803647 958582 4061164..4061865 1 NC_002655.2 hypothetical protein 4061865 yhaK 958582 yhaK Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289680.1 4061164 D 155864 CDS NP_289681.1 15803648 961198 4061882..4062052 1 NC_002655.2 hypothetical protein 4062052 yhaL 961198 yhaL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289681.1 4061882 D 155864 CDS NP_289682.1 15803649 961203 complement(4062186..4063496) 1 NC_002655.2 hypothetical protein 4063496 961203 Z4462 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289682.1 4062186 R 155864 CDS NP_289683.1 15803650 960249 complement(4063524..4064855) 1 NC_002655.2 transport system permease 4064855 yhaO 960249 yhaO Escherichia coli O157:H7 str. EDL933 transport system permease NP_289683.1 4063524 R 155864 CDS NP_289684.1 15803651 958585 complement(4065130..4066500) 1 NC_002655.2 L-serine deaminase 4066500 958585 Z4464 Escherichia coli O157:H7 str. EDL933 L-serine deaminase NP_289684.1 4065130 R 155864 CDS NP_289685.1 15803652 961449 complement(4066566..4067018) 1 NC_002655.2 hypothetical protein 4067018 yhaR 961449 yhaR Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289685.1 4066566 R 155864 CDS NP_289686.1 15803653 958549 complement(4066969..4069263) 1 NC_002655.2 formate acetyltransferase 3 4069263 tdcE 958549 tdcE Escherichia coli O157:H7 str. EDL933 formate acetyltransferase 3 NP_289686.1 4066969 R 155864 CDS NP_289687.1 15803654 958587 complement(4069297..4070517) 1 NC_002655.2 catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism; propionate/acetate kinase 4070517 tdcD 958587 tdcD Escherichia coli O157:H7 str. EDL933 propionate/acetate kinase NP_289687.1 4069297 R 155864 CDS NP_289688.1 15803655 961447 complement(4070531..4071862) 1 NC_002655.2 involved in the import of threonine and serine in combination with the import of a proton; threonine/serine transporter TdcC 4071862 tdcC 961447 tdcC Escherichia coli O157:H7 str. EDL933 threonine/serine transporter TdcC NP_289688.1 4070531 R 155864 CDS NP_289689.1 15803656 958586 complement(4071884..4072873) 1 NC_002655.2 catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; threonine dehydratase 4072873 tdcB 958586 tdcB Escherichia coli O157:H7 str. EDL933 threonine dehydratase NP_289689.1 4071884 R 155864 CDS NP_289690.1 15803657 961446 complement(4072972..4073910) 1 NC_002655.2 regulates the tdcABCDEFG operon which is involved in amino acid degradation; DNA-binding transcriptional activator TdcA 4073910 tdcA 961446 tdcA Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional activator TdcA NP_289690.1 4072972 R 155864 CDS NP_289691.1 15803658 958589 4074099..4074443 1 NC_002655.2 participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon; DNA-binding transcriptional activator TdcR 4074443 tdcR 958589 tdcR Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional activator TdcR NP_289691.1 4074099 D 155864 CDS NP_289692.1 15803659 960252 4074678..4075238 1 NC_002655.2 hypothetical protein 4075238 yhaB 960252 yhaB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289692.1 4074678 D 155864 CDS NP_289693.1 15803660 959211 4075260..4076447 1 NC_002655.2 hypothetical protein 4076447 yhaC 959211 yhaC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289693.1 4075260 D 155864 CDS NP_289695.2 161367521 958591 complement(4077076..4078221) 1 NC_002655.2 glycerate kinase 4078221 yhaD 958591 yhaD Escherichia coli O157:H7 str. EDL933 glycerate kinase NP_289695.2 4077076 R 155864 CDS NP_289696.2 161367520 961202 complement(4078318..4079208) 1 NC_002655.2 catalyzes the reduction of tartronate semialdehyde to glycerate; tartronate semialdehyde reductase 4079208 garR 961202 garR Escherichia coli O157:H7 str. EDL933 tartronate semialdehyde reductase NP_289696.2 4078318 R 155864 CDS NP_289697.1 15803664 958592 complement(4079238..4080008) 1 NC_002655.2 cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate; alpha-dehydro-beta-deoxy-D-glucarate aldolase 4080008 yhaF 958592 yhaF Escherichia coli O157:H7 str. EDL933 alpha-dehydro-beta-deoxy-D-glucarate aldolase NP_289697.1 4079238 R 155864 CDS NP_289698.1 15803665 958584 complement(4080024..4081358) 1 NC_002655.2 transporter 4081358 yhaU 958584 yhaU Escherichia coli O157:H7 str. EDL933 transporter NP_289698.1 4080024 R 155864 CDS NP_289699.1 15803666 958606 4081733..4083304 1 NC_002655.2 hydrolase 4083304 yhaG 958606 yhaG Escherichia coli O157:H7 str. EDL933 hydrolase NP_289699.1 4081733 D 155864 CDS NP_289700.1 15803667 958593 4083453..4083788 1 NC_002655.2 SohA; PrlF; involved in protein secretion; when overproduced or mutated, it induces growth defect and increased export of a reporter protein; a PrlF mutation induces the activity of the Lon protease, and a Lon-deficient strain suppresses the phenotype conferred by the PrlF mutation; regulator PrlF 4083788 sohA 958593 sohA Escherichia coli O157:H7 str. EDL933 regulator PrlF NP_289700.1 4083453 D 155864 CDS NP_289701.1 15803668 958363 4083788..4084252 1 NC_002655.2 hypothetical protein 4084252 yhaV 958363 yhaV Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289701.1 4083788 D 155864 CDS NP_289702.1 15803669 958202 complement(4084307..4085116) 1 NC_002655.2 transcriptional repressor for the agaZVWA and agaSYBCDI operons; DNA-binding transcriptional regulator AgaR 4085116 agaR 958202 agaR Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator AgaR NP_289702.1 4084307 R 155864 CDS NP_289703.1 15803670 958594 4085365..4086645 1 NC_002655.2 tagatose 6-phosphate kinase 2 4086645 agaZ 958594 agaZ Escherichia coli O157:H7 str. EDL933 tagatose 6-phosphate kinase 2 NP_289703.1 4085365 D 155864 CDS NP_289704.1 15803671 958596 4086632..4087141 1 NC_002655.2 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake;involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 4087141 agaV 958596 agaV Escherichia coli O157:H7 str. EDL933 PTS system N-acetylgalactosamine-specific transporter subunit IIB NP_289704.1 4086632 D 155864 CDS NP_289705.1 15803672 959218 4087152..4087931 1 NC_002655.2 phosphotransferase system enzyme subunit 4087931 959218 Z4486 Escherichia coli O157:H7 str. EDL933 phosphotransferase system enzyme subunit NP_289705.1 4087152 D 155864 CDS NP_289706.1 15803673 961206 4087921..4088799 1 NC_002655.2 phosphotransferase system enzyme subunit 4088799 961206 Z4487 Escherichia coli O157:H7 str. EDL933 phosphotransferase system enzyme subunit NP_289706.1 4087921 D 155864 CDS NP_289707.1 15803674 959227 4088817..4089251 1 NC_002655.2 phosphotransferase system enzyme subunit 4089251 959227 Z4488 Escherichia coli O157:H7 str. EDL933 phosphotransferase system enzyme subunit NP_289707.1 4088817 D 155864 CDS NP_289708.1 15803675 958598 4089248..4090381 1 NC_002655.2 N-acetylgalctosamine-6-phosphate deacetylase 4090381 958598 Z4489 Escherichia coli O157:H7 str. EDL933 N-acetylgalctosamine-6-phosphate deacetylase NP_289708.1 4089248 D 155864 CDS NP_289709.1 15803676 959215 4090732..4091886 1 NC_002655.2 tagatose-6-phosphate aldose/ketose isomerase 4091886 agaS 959215 agaS Escherichia coli O157:H7 str. EDL933 tagatose-6-phosphate aldose/ketose isomerase NP_289709.1 4090732 D 155864 CDS NP_289710.1 15803677 958597 4091899..4092759 1 NC_002655.2 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 4092759 kbaY 958597 kbaY Escherichia coli O157:H7 str. EDL933 tagatose-bisphosphate aldolase NP_289710.1 4091899 D 155864 CDS NP_289711.1 15803678 959220 4092926..4093402 1 NC_002655.2 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 4093402 agaB 959220 agaB Escherichia coli O157:H7 str. EDL933 PTS system N-acetylgalactosamine-specific transporter subunit IIB NP_289711.1 4092926 D 155864 CDS NP_289712.1 15803679 958595 4093669..4094244 1 NC_002655.2 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane;protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIC 4094244 agaC 958595 agaC Escherichia coli O157:H7 str. EDL933 PTS system N-acetylgalactosamine-specific transporter subunit IIC NP_289712.1 4093669 D 155864 CDS NP_289713.1 15803680 958600 4094234..4095025 1 NC_002655.2 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IID 4095025 agaD 958600 agaD Escherichia coli O157:H7 str. EDL933 PTS system N-acetylgalactosamine-specific transporter subunit IID NP_289713.1 4094234 D 155864 CDS NP_289714.1 15804981 959638 4095026..4095781 1 NC_002655.2 galactosamine-6-phosphate isomerase 4095781 agaI 959638 agaI Escherichia coli O157:H7 str. EDL933 galactosamine-6-phosphate isomerase NP_289714.1 4095026 D 155864 CDS NP_289715.1 15803681 959441 4096182..4096766 1 NC_002655.2 fimbrial-like protein 4096766 yraH 959441 yraH Escherichia coli O157:H7 str. EDL933 fimbrial-like protein NP_289715.1 4096182 D 155864 CDS NP_289716.1 15803682 959450 4096846..4097541 1 NC_002655.2 chaperone 4097541 yraI 959450 yraI Escherichia coli O157:H7 str. EDL933 chaperone NP_289716.1 4096846 D 155864 CDS NP_289717.1 15803683 957181 4097570..4100086 1 NC_002655.2 hypothetical protein 4100086 yraJ 957181 yraJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289717.1 4097570 D 155864 CDS NP_289718.1 15803684 959296 4099926..4100450 1 NC_002655.2 hypothetical protein 4100450 959296 Z4501 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289718.1 4099926 D 155864 CDS NP_289719.1 15803685 959239 4100476..4100802 1 NC_002655.2 hypothetical protein 4100802 959239 Z4502 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289719.1 4100476 D 155864 CDS NP_289720.1 15803686 960271 4101042..4101689 1 NC_002655.2 transposase 4101689 960271 Z4503 Escherichia coli O157:H7 str. EDL933 transposase NP_289720.1 4101042 D 155864 CDS NP_289721.1 15803687 959238 4101655..4102146 1 NC_002655.2 fimbrial protein 4102146 959238 Z4504 Escherichia coli O157:H7 str. EDL933 fimbrial protein NP_289721.1 4101655 D 155864 CDS NP_289722.1 15803688 958599 complement(4102189..4103049) 1 NC_002655.2 hypothetical protein 4103049 yraL 958599 yraL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289722.1 4102189 R 155864 CDS NP_289723.1 15803689 958602 4103114..4105150 1 NC_002655.2 glycosylase 4105150 yraM 958602 yraM Escherichia coli O157:H7 str. EDL933 glycosylase NP_289723.1 4103114 D 155864 CDS NP_289724.1 15803690 959252 4105108..4105503 1 NC_002655.2 hypothetical protein 4105503 yraN 959252 yraN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289724.1 4105108 D 155864 CDS NP_289725.1 15803691 961219 4105523..4106113 1 NC_002655.2 Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein; chromosome replication initiator DnaA 4106113 yraO 961219 yraO Escherichia coli O157:H7 str. EDL933 chromosome replication initiator DnaA NP_289725.1 4105523 D 155864 CDS NP_289726.1 15803692 959254 4106123..4106698 1 NC_002655.2 hypothetical protein 4106698 yraP 959254 yraP Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289726.1 4106123 D 155864 CDS NP_289727.1 15803693 958603 complement(4106812..4107852) 1 NC_002655.2 hypothetical protein 4107852 yraQ 958603 yraQ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289727.1 4106812 R 155864 CDS NP_289728.1 15803694 959246 complement(4107925..4108605) 1 NC_002655.2 hypothetical protein 4108605 yraR 959246 yraR Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289728.1 4107925 R 155864 CDS NP_289729.1 15803695 959258 4108646..4109206 1 NC_002655.2 hypothetical protein 4109206 yhbO 959258 yhbO Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289729.1 4108646 D 155864 CDS NP_289730.1 15803696 959216 complement(4109186..4109629) 1 NC_002655.2 hypothetical protein 4109629 yhbP 959216 yhbP Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289730.1 4109186 R 155864 CDS NP_289731.1 15803697 959214 4109680..4109982 1 NC_002655.2 GIY-YIG nuclease superfamily protein 4109982 yhbQ 959214 yhbQ Escherichia coli O157:H7 str. EDL933 GIY-YIG nuclease superfamily protein NP_289731.1 4109680 D 155864 CDS NP_289732.1 15803698 958604 complement(4109969..4110472) 1 NC_002655.2 hypothetical protein 4110472 yhbS 958604 yhbS Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289732.1 4109969 R 155864 CDS NP_289733.1 15803699 959247 complement(4110466..4110990) 1 NC_002655.2 hypothetical protein 4110990 yhbT 959247 yhbT Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289733.1 4110466 R 155864 CDS NP_289734.1 15803700 959250 4111199..4112194 1 NC_002655.2 collagenase 4112194 yhbU 959250 yhbU Escherichia coli O157:H7 str. EDL933 collagenase NP_289734.1 4111199 D 155864 CDS NP_289735.1 15803701 961217 4112185..4113081 1 NC_002655.2 hypothetical protein 4113081 yhbV 961217 yhbV Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289735.1 4112185 D 155864 CDS NP_289736.1 15803702 959248 4113162..4114169 1 NC_002655.2 hypothetical protein 4114169 yhbW 959248 yhbW Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289736.1 4113162 D 155864 CDS NP_289737.1 15803703 958605 complement(4114286..4115530) 1 NC_002655.2 tryptophan transporter of high affinity; tryptophan permease 4115530 mtr 958605 mtr Escherichia coli O157:H7 str. EDL933 tryptophan permease NP_289737.1 4114286 R 155864 CDS NP_289738.2 161367519 958607 complement(4115684..4117573) 1 NC_002655.2 participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division; ATP-dependent RNA helicase DeaD 4117573 deaD 958607 deaD Escherichia coli O157:H7 str. EDL933 ATP-dependent RNA helicase DeaD NP_289738.2 4115684 R 155864 CDS NP_289739.1 15803705 958608 complement(4117753..4118637) 1 NC_002655.2 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; lipoprotein NlpI 4118637 yhbM 958608 yhbM Escherichia coli O157:H7 str. EDL933 lipoprotein NlpI NP_289739.1 4117753 R 155864 CDS NP_289740.1 15803706 958609 complement(4118746..4120950) 1 NC_002655.2 polynucleotide phosphorylase 4120950 pnp 958609 pnp Escherichia coli O157:H7 str. EDL933 polynucleotide phosphorylase NP_289740.1 4118746 R 155864 CDS NP_289741.1 15803707 960736 complement(4121128..4121397) 1 NC_002655.2 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 4121397 rpsO 960736 rpsO Escherichia coli O157:H7 str. EDL933 30S ribosomal protein S15 NP_289741.1 4121128 R 155864 CDS NP_289742.1 15803708 960733 complement(4121546..4122490) 1 NC_002655.2 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 4122490 truB 960733 truB Escherichia coli O157:H7 str. EDL933 tRNA pseudouridine synthase B NP_289742.1 4121546 R 155864 CDS NP_289743.1 15803709 958611 complement(4122490..4122891) 1 NC_002655.2 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 4122891 rbfA 958611 rbfA Escherichia coli O157:H7 str. EDL933 ribosome-binding factor A NP_289743.1 4122490 R 155864 CDS NP_289744.1 15803710 958612 complement(4123056..4125728) 1 NC_002655.2 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 4125728 infB 958612 infB Escherichia coli O157:H7 str. EDL933 translation initiation factor IF-2 NP_289744.1 4123056 R 155864 CDS NP_289745.1 15803711 958613 complement(4125753..4127240) 1 NC_002655.2 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 4127240 nusA 958613 nusA Escherichia coli O157:H7 str. EDL933 transcription elongation factor NusA NP_289745.1 4125753 R 155864 CDS NP_289746.2 161367518 958614 complement(4127268..4127720) 1 NC_002655.2 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 4127720 yhbC 958614 yhbC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289746.2 4127268 R 155864 CDS NP_289747.1 15803713 958616 4128351..4129694 1 NC_002655.2 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 4129694 argG 958616 argG Escherichia coli O157:H7 str. EDL933 argininosuccinate synthase NP_289747.1 4128351 D 155864 CDS NP_289748.1 15803714 958617 complement(4129702..4131345) 1 NC_002655.2 alkaline phosphatase 4131345 yhbX 958617 yhbX Escherichia coli O157:H7 str. EDL933 alkaline phosphatase NP_289748.1 4129702 R 155864 CDS NP_289749.1 15803715 958619 complement(4131887..4132219) 1 NC_002655.2 preprotein translocase subunit SecG 4132219 secG 958619 secG Escherichia coli O157:H7 str. EDL933 preprotein translocase subunit SecG NP_289749.1 4131887 R 155864 CDS NP_289750.1 15803716 958620 complement(4132447..4133784) 1 NC_002655.2 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 4133784 glmM 958620 glmM Escherichia coli O157:H7 str. EDL933 phosphoglucosamine mutase NP_289750.1 4132447 R 155864 CDS NP_289751.2 161367517 958621 complement(4133777..4134625) 1 NC_002655.2 catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate; dihydropteroate synthase 4134625 folP 958621 folP Escherichia coli O157:H7 str. EDL933 dihydropteroate synthase NP_289751.2 4133777 R 155864 CDS NP_289752.1 15803718 958622 complement(4134715..4136649) 1 NC_002655.2 inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins; ATP-dependent metalloprotease 4136649 hflB 958622 hflB Escherichia coli O157:H7 str. EDL933 ATP-dependent metalloprotease NP_289752.1 4134715 R 155864 CDS NP_289753.1 15803719 958623 complement(4136749..4137378) 1 NC_002655.2 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit; 23S rRNA methyltransferase 4137378 rrmJ 958623 rrmJ Escherichia coli O157:H7 str. EDL933 23S rRNA methyltransferase NP_289753.1 4136749 R 155864 CDS NP_289754.1 15803720 958624 4137504..4137797 1 NC_002655.2 RNA binding protein found associated to pre-50S subunit of the ribosome; role in ribosome assembly; necessary for optimal growth but not cell viability; RNA-binding protein YhbY 4137797 yhbY 958624 yhbY Escherichia coli O157:H7 str. EDL933 RNA-binding protein YhbY NP_289754.1 4137504 D 155864 CDS NP_289755.2 161367516 958625 complement(4137953..4138429) 1 NC_002655.2 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 4138429 greA 958625 greA Escherichia coli O157:H7 str. EDL933 transcription elongation factor GreA NP_289755.2 4137953 R 155864 CDS NP_289756.1 15803722 961450 4138677..4140110 1 NC_002655.2 penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 4140110 dacB 961450 dacB Escherichia coli O157:H7 str. EDL933 D-alanyl-D-alanine carboxypeptidase NP_289756.1 4138677 D 155864 CDS NP_289757.1 15803723 959234 complement(4140150..4141322) 1 NC_002655.2 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 4141322 obgE 959234 obgE Escherichia coli O157:H7 str. EDL933 GTPase ObgE NP_289757.1 4140150 R 155864 CDS NP_289758.1 15803724 958626 complement(4141338..4142303) 1 NC_002655.2 hypothetical protein 4142303 yhbE 958626 yhbE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289758.1 4141338 R 155864 CDS NP_289759.1 15803725 958627 complement(4142430..4142687) 1 NC_002655.2 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 4142687 rpmA 958627 rpmA Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L27 NP_289759.1 4142430 R 155864 CDS NP_289760.1 15803726 958628 complement(4142708..4143019) 1 NC_002655.2 50S ribosomal protein L21 4143019 rplU 958628 rplU Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L21 NP_289760.1 4142708 R 155864 CDS NP_289761.1 15803727 958629 4143278..4144249 1 NC_002655.2 octaprenyl diphosphate synthase 4144249 ispB 958629 ispB Escherichia coli O157:H7 str. EDL933 octaprenyl diphosphate synthase NP_289761.1 4143278 D 155864 CDS NP_289762.1 15803728 958630 4144478..4144756 1 NC_002655.2 activator of maltose metabolism genes; DNA-binding transcriptional regulator Nlp 4144756 nlp 958630 nlp Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator Nlp NP_289762.1 4144478 D 155864 CDS NP_289763.1 15803729 958631 complement(4144804..4146063) 1 NC_002655.2 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 4146063 murA 958631 murA Escherichia coli O157:H7 str. EDL933 UDP-N-acetylglucosamine 1-carboxyvinyltransferase NP_289763.1 4144804 R 155864 CDS NP_289764.1 15803730 958632 complement(4146118..4146387) 1 NC_002655.2 hypothetical protein 4146387 yrbA 958632 yrbA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289764.1 4146118 R 155864 CDS NP_289765.1 15803731 958633 complement(4146532..4146921) 1 NC_002655.2 hypothetical protein 4146921 yrbB 958633 yrbB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289765.1 4146532 R 155864 CDS NP_289766.1 15803732 958634 complement(4146825..4147460) 1 NC_002655.2 hypothetical protein 4147460 yrbC 958634 yrbC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289766.1 4146825 R 155864 CDS NP_289767.1 15803733 958635 complement(4147479..4148030) 1 NC_002655.2 hypothetical protein 4148030 yrbD 958635 yrbD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289767.1 4147479 R 155864 CDS NP_289768.1 15803734 958636 complement(4148035..4148817) 1 NC_002655.2 hypothetical protein 4148817 yrbE 958636 yrbE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289768.1 4148035 R 155864 CDS NP_289769.1 15803735 958637 complement(4148825..4149634) 1 NC_002655.2 ATP-binding subunit of a ABC toluene efflux transporter; ABC transporter ATP-binding protein 4149634 yrbF 958637 yrbF Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_289769.1 4148825 R 155864 CDS NP_289770.1 15803736 957437 4149844..4150821 1 NC_002655.2 YrbG; inner membrane protein involved in cell envelope integrity; sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers; calcium/sodium:proton antiporter 4150821 yrbG 957437 yrbG Escherichia coli O157:H7 str. EDL933 calcium/sodium:proton antiporter NP_289770.1 4149844 D 155864 CDS NP_289771.1 15803737 961401 4150835..4151821 1 NC_002655.2 D-arabinose 5-phosphate isomerase 4151821 yrbH 961401 yrbH Escherichia coli O157:H7 str. EDL933 D-arabinose 5-phosphate isomerase NP_289771.1 4150835 D 155864 CDS NP_289772.1 15803738 958043 4151842..4152408 1 NC_002655.2 forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 4152408 yrbI 958043 yrbI Escherichia coli O157:H7 str. EDL933 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase NP_289772.1 4151842 D 155864 CDS NP_289773.1 15803739 958638 4152405..4152980 1 NC_002655.2 hypothetical protein 4152980 yrbK 958638 yrbK Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289773.1 4152405 D 155864 CDS NP_289774.1 15803740 958639 4152949..4153506 1 NC_002655.2 LptA; periplasmic binding protein part of a ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system; lipopolysaccharide transport periplasmic protein LptA 4153506 yhbN 958639 yhbN Escherichia coli O157:H7 str. EDL933 lipopolysaccharide transport periplasmic protein LptA NP_289774.1 4152949 D 155864 CDS NP_289775.1 15803741 958640 4153513..4154238 1 NC_002655.2 ABC transporter ATP-binding protein 4154238 yhbG 958640 yhbG Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_289775.1 4153513 D 155864 CDS NP_289776.1 15803742 958641 4154286..4155719 1 NC_002655.2 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen; RNA polymerase factor sigma-54 4155719 rpoN 958641 rpoN Escherichia coli O157:H7 str. EDL933 RNA polymerase factor sigma-54 NP_289776.1 4154286 D 155864 CDS NP_289777.1 15803743 958642 4155742..4156029 1 NC_002655.2 YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing; sigma(54) modulation protein 4156029 yhbH 958642 yhbH Escherichia coli O157:H7 str. EDL933 sigma(54) modulation protein NP_289777.1 4155742 D 155864 CDS NP_289778.1 15803744 958643 4156147..4156638 1 NC_002655.2 PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN 4156638 ptsN 958643 ptsN Escherichia coli O157:H7 str. EDL933 PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN NP_289778.1 4156147 D 155864 CDS NP_289779.1 15803745 958645 4156684..4157538 1 NC_002655.2 hypothetical protein 4157538 yhbJ 958645 yhbJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289779.1 4156684 D 155864 CDS NP_289780.1 15803746 958646 4157535..4157807 1 NC_002655.2 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) 4157807 ptsO 958646 ptsO Escherichia coli O157:H7 str. EDL933 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) NP_289780.1 4157535 D 155864 CDS NP_289781.1 15803747 958647 4158021..4158653 1 NC_002655.2 hypothetical protein 4158653 yrbL 958647 yrbL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289781.1 4158021 D 155864 CDS NP_289782.1 15803748 958648 complement(4158650..4159378) 1 NC_002655.2 glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase 4159378 mtgA 958648 mtgA Escherichia coli O157:H7 str. EDL933 monofunctional biosynthetic peptidoglycan transglycosylase NP_289782.1 4158650 R 155864 CDS NP_289783.1 15803749 958649 complement(4159375..4160037) 1 NC_002655.2 isoprenoid biosynthesis protein with amidotransferase-like domain 4160037 yhbL 958649 yhbL Escherichia coli O157:H7 str. EDL933 isoprenoid biosynthesis protein with amidotransferase-like domain NP_289783.1 4159375 R 155864 CDS NP_289784.1 15803750 958650 complement(4160259..4162595) 1 NC_002655.2 sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA; aerobic respiration control sensor protein ArcB 4162595 arcB 958650 arcB Escherichia coli O157:H7 str. EDL933 aerobic respiration control sensor protein ArcB NP_289784.1 4160259 R 155864 CDS NP_289785.1 15803751 958652 complement(4162691..4163620) 1 NC_002655.2 hypothetical protein 4163620 yhcC 958652 yhcC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289785.1 4162691 R 155864 CDS NP_289786.1 15803752 958654 4164201..4168754 1 NC_002655.2 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; glutamate synthase 4168754 gltB 958654 gltB Escherichia coli O157:H7 str. EDL933 glutamate synthase NP_289786.1 4164201 D 155864 CDS NP_289787.1 15803753 958655 4168767..4170185 1 NC_002655.2 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase 4170185 gltD 958655 gltD Escherichia coli O157:H7 str. EDL933 glutamate synthase NP_289787.1 4168767 D 155864 CDS NP_289788.1 15803754 958656 4170369..4171418 1 NC_002655.2 hypothetical protein 4171418 yhcG 958656 yhcG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289788.1 4170369 D 155864 CDS NP_289789.1 15803755 958657 complement(4171478..4171942) 1 NC_002655.2 hypothetical protein 4171942 yhcH 958657 yhcH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289789.1 4171478 R 155864 CDS NP_289790.2 161367515 958658 complement(4171939..4172814) 1 NC_002655.2 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase 4172814 yhcI 958658 yhcI Escherichia coli O157:H7 str. EDL933 N-acetylmannosamine kinase NP_289790.2 4171939 R 155864 CDS NP_289791.1 15803757 958659 complement(4172811..4173500) 1 NC_002655.2 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 4173500 yhcJ 958659 yhcJ Escherichia coli O157:H7 str. EDL933 N-acetylmannosamine-6-phosphate 2-epimerase NP_289791.1 4172811 R 155864 CDS NP_289792.2 161367514 958661 complement(4173548..4175038) 1 NC_002655.2 sialic acid transporter 4175038 nanT 958661 nanT Escherichia coli O157:H7 str. EDL933 sialic acid transporter NP_289792.2 4173548 R 155864 CDS NP_289793.1 15803759 958662 complement(4175147..4176040) 1 NC_002655.2 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase 4176040 nanA 958662 nanA Escherichia coli O157:H7 str. EDL933 N-acetylneuraminate lyase NP_289793.1 4175147 R 155864 CDS NP_289794.1 15803760 958663 complement(4176162..4176953) 1 NC_002655.2 Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization; transcriptional regulator NanR 4176953 yhcK 958663 yhcK Escherichia coli O157:H7 str. EDL933 transcriptional regulator NanR NP_289794.1 4176162 R 155864 CDS NP_289795.1 15803761 958665 4177333..4178697 1 NC_002655.2 YhcL; uncharacterized member of the DcuC family of anaerobic dicarboxylate transporters; probable role in transport of carboxylates across the inner membrane from the periplasm; its encoding gene is not essential for growth and is probably cryptic; cryptic C4-dicarboxylate transporter DcuD 4178697 958665 Z4585 Escherichia coli O157:H7 str. EDL933 cryptic C4-dicarboxylate transporter DcuD NP_289795.1 4177333 D 155864 CDS NP_289796.1 15803762 958666 complement(4178732..4179229) 1 NC_002655.2 ClpXP protease specificity-enhancing factor 4179229 sspB 958666 sspB Escherichia coli O157:H7 str. EDL933 ClpXP protease specificity-enhancing factor NP_289796.1 4178732 R 155864 CDS NP_289797.1 15803763 959207 complement(4179235..4179873) 1 NC_002655.2 transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation; stringent starvation protein A 4179873 sspA 959207 sspA Escherichia coli O157:H7 str. EDL933 stringent starvation protein A NP_289797.1 4179235 R 155864 CDS NP_289798.1 15803764 958573 complement(4180268..4180660) 1 NC_002655.2 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 4180660 rpsI 958573 rpsI Escherichia coli O157:H7 str. EDL933 30S ribosomal protein S9 NP_289798.1 4180268 R 155864 CDS NP_289799.1 15803765 959313 complement(4180676..4181104) 1 NC_002655.2 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 4181104 rplM 959313 rplM Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L13 NP_289799.1 4180676 R 155864 CDS NP_289800.1 15803766 957298 complement(4181323..4182450) 1 NC_002655.2 hypothetical protein 4182450 yhcM 957298 yhcM Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289800.1 4181323 R 155864 CDS NP_289801.1 15803767 958667 4182638..4183042 1 NC_002655.2 cytochrome d ubiquinol oxidase subunit III 4183042 yhcB 958667 yhcB Escherichia coli O157:H7 str. EDL933 cytochrome d ubiquinol oxidase subunit III NP_289801.1 4182638 D 155864 CDS NP_289802.1 15803768 958668 4183196..4184563 1 NC_002655.2 serine endoprotease 4184563 degQ 958668 degQ Escherichia coli O157:H7 str. EDL933 serine endoprotease NP_289802.1 4183196 D 155864 CDS NP_289803.1 15803769 958669 4184653..4185720 1 NC_002655.2 serine endoprotease 4185720 degS 958669 degS Escherichia coli O157:H7 str. EDL933 serine endoprotease NP_289803.1 4184653 D 155864 CDS NP_289804.1 15803770 958670 complement(4185784..4186722) 1 NC_002655.2 oxidizes malate to oxaloacetate; malate dehydrogenase 4186722 mdh 958670 mdh Escherichia coli O157:H7 str. EDL933 malate dehydrogenase NP_289804.1 4185784 R 155864 CDS NP_289805.1 15803771 958671 4187157..4187627 1 NC_002655.2 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor ArgR 4187627 argR 958671 argR Escherichia coli O157:H7 str. EDL933 arginine repressor ArgR NP_289805.1 4187157 D 155864 CDS NP_289806.1 15803772 958673 4187941..4188255 1 NC_002655.2 hypothetical protein 4188255 yhcN 958673 yhcN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289806.1 4187941 D 155864 CDS NP_289807.1 15803773 958674 complement(4188311..4188583) 1 NC_002655.2 hypothetical protein 4188583 yhcO 958674 yhcO Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289807.1 4188311 R 155864 CDS NP_289808.1 15803774 958675 complement(4188676..4190643) 1 NC_002655.2 with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeB 4190643 yhcP 958675 yhcP Escherichia coli O157:H7 str. EDL933 p-hydroxybenzoic acid efflux subunit AaeB NP_289808.1 4188676 R 155864 CDS NP_289809.1 15803775 958676 complement(4190649..4191578) 1 NC_002655.2 with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeA 4191578 yhcQ 958676 yhcQ Escherichia coli O157:H7 str. EDL933 p-hydroxybenzoic acid efflux subunit AaeA NP_289809.1 4190649 R 155864 CDS NP_289810.2 161367513 958677 complement(4191586..4191789) 1 NC_002655.2 membrane protein AaeX; the gene is a member of the aaeXAB operon; hypothetical protein 4191789 yhcR 958677 yhcR Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289810.2 4191586 R 155864 CDS NP_289811.1 15803777 958678 4191972..4192901 1 NC_002655.2 QseA; DNA-binding transcriptional regulator 4192901 qseA 958678 qseA Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator NP_289811.1 4191972 D 155864 CDS NP_289812.1 15803778 958679 complement(4193035..4194480) 1 NC_002655.2 responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA; protease TldD 4194480 tldD 958679 tldD Escherichia coli O157:H7 str. EDL933 protease TldD NP_289812.1 4193035 R 155864 CDS NP_289813.1 15803779 958680 complement(4194636..4198436) 1 NC_002655.2 hypothetical protein 4198436 958680 Z4604 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289813.1 4194636 R 155864 CDS NP_289814.2 161367512 958681 complement(4198504..4199973) 1 NC_002655.2 involved in the processing of the 5'end of 16S rRNA; ribonuclease G 4199973 cafA 958681 cafA Escherichia coli O157:H7 str. EDL933 ribonuclease G NP_289814.2 4198504 R 155864 CDS NP_289815.1 15803781 958682 complement(4199963..4200556) 1 NC_002655.2 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 4200556 maf 958682 maf Escherichia coli O157:H7 str. EDL933 Maf-like protein NP_289815.1 4199963 R 155864 CDS NP_289816.1 15803782 958683 complement(4200565..4201053) 1 NC_002655.2 part of cell wall structural complex MreBCD; transmembrane component; rod shape-determining protein MreD 4201053 mreD 958683 mreD Escherichia coli O157:H7 str. EDL933 rod shape-determining protein MreD NP_289816.1 4200565 R 155864 CDS NP_289817.1 15803783 958684 complement(4201053..4202156) 1 NC_002655.2 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 4202156 mreC 958684 mreC Escherichia coli O157:H7 str. EDL933 rod shape-determining protein MreC NP_289817.1 4201053 R 155864 CDS NP_289818.2 228979044 958686 complement(4202222..4203265) 1 NC_002655.2 functions in MreBCD complex in some organisms; rod shape-determining protein MreB 4203265 mreB 958686 mreB Escherichia coli O157:H7 str. EDL933 rod shape-determining protein MreB NP_289818.2 4202222 R 155864 CDS NP_289819.1 15803785 958688 complement(4203570..4205510) 1 NC_002655.2 regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules; regulatory protein CsrD 4205510 yhdA 958688 yhdA Escherichia coli O157:H7 str. EDL933 regulatory protein CsrD NP_289819.1 4203570 R 155864 CDS NP_289820.1 15803786 958689 4205662..4206636 1 NC_002655.2 dehydrogenase 4206636 yhdH 958689 yhdH Escherichia coli O157:H7 str. EDL933 dehydrogenase NP_289820.1 4205662 D 155864 CDS NP_289821.1 15803787 958690 complement(4206694..4206795) 1 NC_002655.2 hypothetical protein 4206795 958690 Z4613 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289821.1 4206694 R 155864 CDS NP_289822.1 15803788 958691 4206922..4207041 1 NC_002655.2 hypothetical protein 4207041 958691 Z4614 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289822.1 4206922 D 155864 CDS NP_289823.1 15803789 958692 4207614..4208084 1 NC_002655.2 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 4208084 accB 958692 accB Escherichia coli O157:H7 str. EDL933 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit NP_289823.1 4207614 D 155864 CDS NP_289824.1 15803790 958693 4208095..4209444 1 NC_002655.2 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 4209444 accC 958693 accC Escherichia coli O157:H7 str. EDL933 acetyl-CoA carboxylase biotin carboxylase subunit NP_289824.1 4208095 D 155864 CDS NP_289825.1 15803791 958694 4209553..4209795 1 NC_002655.2 hypothetical protein 4209795 yhdT 958694 yhdT Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289825.1 4209553 D 155864 CDS NP_289826.2 161367511 958695 4209785..4211236 1 NC_002655.2 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 4211236 panF 958695 panF Escherichia coli O157:H7 str. EDL933 sodium/panthothenate symporter NP_289826.2 4209785 D 155864 CDS NP_289827.1 15803793 958696 4211248..4212129 1 NC_002655.2 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase 4212129 prmA 958696 prmA Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L11 methyltransferase NP_289827.1 4211248 D 155864 CDS NP_289828.1 15803794 958697 4212458..4213423 1 NC_002655.2 tRNA-dihydrouridine synthase B 4213423 yhdG 958697 yhdG Escherichia coli O157:H7 str. EDL933 tRNA-dihydrouridine synthase B NP_289828.1 4212458 D 155864 CDS NP_289829.1 15803795 958698 4213449..4213745 1 NC_002655.2 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; Fis family transcriptional regulator 4213745 fis 958698 fis Escherichia coli O157:H7 str. EDL933 Fis family transcriptional regulator NP_289829.1 4213449 D 155864 CDS NP_289830.2 161367510 958699 4213830..4214714 1 NC_002655.2 methyltransferase 4214714 yhdJ 958699 yhdJ Escherichia coli O157:H7 str. EDL933 methyltransferase NP_289830.2 4213830 D 155864 CDS NP_289831.1 15803797 958704 4214798..4214977 1 NC_002655.2 hypothetical protein 4214977 yhdU 958704 yhdU Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289831.1 4214798 D 155864 CDS NP_289832.1 15803798 958706 complement(4214980..4215642) 1 NC_002655.2 DNA-binding transcriptional regulator EnvR 4215642 envR 958706 envR Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator EnvR NP_289832.1 4214980 R 155864 CDS NP_289833.1 15803799 958709 4216041..4217198 1 NC_002655.2 transmembrane protein affects septum formation and cell membrane permeability 4217198 acrE 958709 acrE Escherichia coli O157:H7 str. EDL933 transmembrane protein affects septum formation and cell membrane permeability NP_289833.1 4216041 D 155864 CDS NP_289834.1 15803800 958713 4217210..4219096 1 NC_002655.2 hypothetical protein 4219096 acrF_1 958713 acrF_1 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289834.1 4217210 D 155864 CDS NP_289835.1 15803801 958537 4219127..4220359 1 NC_002655.2 hypothetical protein 4220359 acrF_2 958537 acrF_2 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289835.1 4219127 D 155864 CDS NP_289836.1 15803802 958707 4220612..4220833 1 NC_002655.2 hypothetical protein 4220833 yhdV 958707 yhdV Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289836.1 4220612 D 155864 CDS NP_289837.1 15803803 961457 4221372..4222289 1 NC_002655.2 periplasmic binding transport protein 4222289 yhdW 961457 yhdW Escherichia coli O157:H7 str. EDL933 periplasmic binding transport protein NP_289837.1 4221372 D 155864 CDS NP_289838.1 15803804 958716 4222357..4223538 1 NC_002655.2 transport system permease 4223538 yhdX 958716 yhdX Escherichia coli O157:H7 str. EDL933 transport system permease NP_289838.1 4222357 D 155864 CDS NP_289839.1 15803805 958703 4223545..4224651 1 NC_002655.2 transport system permease 4224651 yhdY 958703 yhdY Escherichia coli O157:H7 str. EDL933 transport system permease NP_289839.1 4223545 D 155864 CDS NP_289840.1 15803806 958701 4224659..4225417 1 NC_002655.2 ABC transporter ATP-binding protein 4225417 yhdZ 958701 yhdZ Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_289840.1 4224659 D 155864 CDS NP_289841.1 15803807 958731 4231254..4232024 1 NC_002655.2 transferase 4232024 958731 Z4650 Escherichia coli O157:H7 str. EDL933 transferase NP_289841.1 4231254 D 155864 CDS NP_289842.1 15803808 961469 complement(4232000..4232257) 1 NC_002655.2 hypothetical protein 4232257 yrdB 961469 yrdB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289842.1 4232000 R 155864 CDS NP_289843.1 15803809 958734 complement(4232254..4233072) 1 NC_002655.2 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 4233072 aroE 958734 aroE Escherichia coli O157:H7 str. EDL933 shikimate 5-dehydrogenase NP_289843.1 4232254 R 155864 CDS NP_289844.1 15803810 958732 complement(4233077..4233649) 1 NC_002655.2 RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA; ribosome maturation factor 4233649 yrdC 958732 yrdC Escherichia coli O157:H7 str. EDL933 ribosome maturation factor NP_289844.1 4233077 R 155864 CDS NP_289845.1 15803811 959325 complement(4233654..4234172) 1 NC_002655.2 DNA topoisomerase 4234172 yrdD 959325 yrdD Escherichia coli O157:H7 str. EDL933 DNA topoisomerase NP_289845.1 4233654 R 155864 CDS NP_289846.1 15803812 957231 complement(4234225..4234698) 1 NC_002655.2 hypothetical protein 4234698 smg 957231 smg Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289846.1 4234225 R 155864 CDS NP_289847.1 15803813 958737 complement(4234670..4235794) 1 NC_002655.2 DNA protecting protein DprA 4235794 smf 958737 smf Escherichia coli O157:H7 str. EDL933 DNA protecting protein DprA NP_289847.1 4234670 R 155864 CDS NP_289848.1 15803814 961473 4235924..4236433 1 NC_002655.2 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 4236433 def 961473 def Escherichia coli O157:H7 str. EDL933 peptide deformylase NP_289848.1 4235924 D 155864 CDS NP_289849.1 15803815 958738 4236448..4237395 1 NC_002655.2 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 4237395 fmt 958738 fmt Escherichia coli O157:H7 str. EDL933 methionyl-tRNA formyltransferase NP_289849.1 4236448 D 155864 CDS NP_289850.1 15803816 958740 4237441..4238730 1 NC_002655.2 catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase; 16S rRNA methyltransferase GidB 4238730 sun 958740 sun Escherichia coli O157:H7 str. EDL933 16S rRNA methyltransferase GidB NP_289850.1 4237441 D 155864 CDS NP_289851.1 15803817 961474 4238752..4240128 1 NC_002655.2 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane protein 4240128 trkA 961474 trkA Escherichia coli O157:H7 str. EDL933 potassium transporter peripheral membrane protein NP_289851.1 4238752 D 155864 CDS NP_289852.1 15803818 958756 4240258..4240668 1 NC_002655.2 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 4240668 mscL 958756 mscL Escherichia coli O157:H7 str. EDL933 large-conductance mechanosensitive channel NP_289852.1 4240258 D 155864 CDS NP_289853.2 157267372 958746 complement(4240939..4241364) 1 NC_002655.2 mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators; zinc-responsive transcriptional regulator 4241364 zntR 958746 zntR Escherichia coli O157:H7 str. EDL933 zinc-responsive transcriptional regulator NP_289853.2 4240939 R 155864 CDS NP_289854.1 15803820 961494 complement(4241375..4241743) 1 NC_002655.2 hypothetical protein 4241743 yhdN 961494 yhdN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289854.1 4241375 R 155864 CDS NP_289855.1 15803821 958759 complement(4241850..4242233) 1 NC_002655.2 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 4242233 rplQ 958759 rplQ Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L17 NP_289855.1 4241850 R 155864 CDS NP_289856.1 15803822 958748 complement(4242274..4243263) 1 NC_002655.2 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 4243263 rpoA 958748 rpoA Escherichia coli O157:H7 str. EDL933 DNA-directed RNA polymerase subunit alpha NP_289856.1 4242274 R 155864 CDS NP_289857.1 15803823 961480 complement(4243289..4243909) 1 NC_002655.2 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 4243909 rpsD 961480 rpsD Escherichia coli O157:H7 str. EDL933 30S ribosomal protein S4 NP_289857.1 4243289 R 155864 CDS NP_289858.1 15803824 958770 complement(4243943..4244332) 1 NC_002655.2 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 4244332 rpsK 958770 rpsK Escherichia coli O157:H7 str. EDL933 30S ribosomal protein S11 NP_289858.1 4243943 R 155864 CDS NP_289859.1 15803825 961491 complement(4244349..4244705) 1 NC_002655.2 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 4244705 rpsM 961491 rpsM Escherichia coli O157:H7 str. EDL933 30S ribosomal protein S13 NP_289859.1 4244349 R 155864 CDS NP_289860.1 15803826 958730 complement(4244852..4244968) 1 NC_002655.2 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 4244968 rpmJ 958730 rpmJ Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L36 NP_289860.1 4244852 R 155864 CDS NP_289861.1 15803827 958757 complement(4245000..4246331) 1 NC_002655.2 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 4246331 secY 958757 secY Escherichia coli O157:H7 str. EDL933 preprotein translocase subunit SecY NP_289861.1 4245000 R 155864 CDS NP_289862.1 15803828 961484 complement(4246339..4246773) 1 NC_002655.2 late assembly protein; 50S ribosomal protein L15 4246773 rplO 961484 rplO Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L15 NP_289862.1 4246339 R 155864 CDS NP_289863.1 15803829 958758 complement(4246777..4246956) 1 NC_002655.2 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 4246956 rpmD 958758 rpmD Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L30 NP_289863.1 4246777 R 155864 CDS NP_289864.1 15803830 961486 complement(4246960..4247463) 1 NC_002655.2 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 4247463 rpsE 961486 rpsE Escherichia coli O157:H7 str. EDL933 30S ribosomal protein S5 NP_289864.1 4246960 R 155864 CDS NP_289865.1 15803831 958760 complement(4247478..4247831) 1 NC_002655.2 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 4247831 rplR 958760 rplR Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L18 NP_289865.1 4247478 R 155864 CDS NP_289866.1 15803832 958750 complement(4247841..4248374) 1 NC_002655.2 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 4248374 rplF 958750 rplF Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L6 NP_289866.1 4247841 R 155864 CDS NP_289867.1 15803833 958728 complement(4248387..4248779) 1 NC_002655.2 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 4248779 rpsH 958728 rpsH Escherichia coli O157:H7 str. EDL933 30S ribosomal protein S8 NP_289867.1 4248387 R 155864 CDS NP_289868.1 15803834 958763 complement(4248813..4249118) 1 NC_002655.2 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 4249118 rpsN 958763 rpsN Escherichia coli O157:H7 str. EDL933 30S ribosomal protein S14 NP_289868.1 4248813 R 155864 CDS NP_289869.1 15803835 958768 complement(4249133..4249672) 1 NC_002655.2 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 4249672 rplE 958768 rplE Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L5 NP_289869.1 4249133 R 155864 CDS NP_289870.1 15803836 961490 complement(4249687..4250001) 1 NC_002655.2 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 4250001 rplX 961490 rplX Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L24 NP_289870.1 4249687 R 155864 CDS NP_289871.1 15803837 958775 complement(4250012..4250383) 1 NC_002655.2 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 4250383 rplN 958775 rplN Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L14 NP_289871.1 4250012 R 155864 CDS NP_289872.1 15803838 958773 complement(4250548..4250802) 1 NC_002655.2 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 4250802 rpsQ 958773 rpsQ Escherichia coli O157:H7 str. EDL933 30S ribosomal protein S17 NP_289872.1 4250548 R 155864 CDS NP_289873.1 15803839 961497 complement(4250802..4250993) 1 NC_002655.2 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 4250993 rpmC 961497 rpmC Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L29 NP_289873.1 4250802 R 155864 CDS NP_289874.1 15803840 958767 complement(4250993..4251403) 1 NC_002655.2 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 4251403 rplP 958767 rplP Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L16 NP_289874.1 4250993 R 155864 CDS NP_289875.1 15803841 961493 complement(4251416..4252117) 1 NC_002655.2 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 4252117 rpsC 961493 rpsC Escherichia coli O157:H7 str. EDL933 30S ribosomal protein S3 NP_289875.1 4251416 R 155864 CDS NP_289876.1 15803842 958554 complement(4252135..4252467) 1 NC_002655.2 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 4252467 rplV 958554 rplV Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L22 NP_289876.1 4252135 R 155864 CDS NP_289877.1 15803843 958783 complement(4252482..4252760) 1 NC_002655.2 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 4252760 rpsS 958783 rpsS Escherichia coli O157:H7 str. EDL933 30S ribosomal protein S19 NP_289877.1 4252482 R 155864 CDS NP_289878.1 15803844 961506 complement(4252777..4253598) 1 NC_002655.2 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 4253598 rplB 961506 rplB Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L2 NP_289878.1 4252777 R 155864 CDS NP_289879.1 15803845 958774 complement(4253616..4253918) 1 NC_002655.2 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 4253918 rplW 958774 rplW Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L23 NP_289879.1 4253616 R 155864 CDS NP_289880.1 15803846 961496 complement(4253915..4254520) 1 NC_002655.2 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 4254520 rplD 961496 rplD Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L4 NP_289880.1 4253915 R 155864 CDS NP_289881.1 15803847 961453 complement(4254531..4255160) 1 NC_002655.2 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 4255160 rplC 961453 rplC Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L3 NP_289881.1 4254531 R 155864 CDS NP_289882.1 15803848 958790 complement(4255193..4255504) 1 NC_002655.2 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 4255504 rpsJ 958790 rpsJ Escherichia coli O157:H7 str. EDL933 30S ribosomal protein S10 NP_289882.1 4255193 R 155864 CDS NP_289883.1 15803849 958791 4255883..4256350 1 NC_002655.2 leader peptidase 4256350 hopD 958791 hopD Escherichia coli O157:H7 str. EDL933 leader peptidase NP_289883.1 4255883 D 155864 CDS NP_289884.1 15803850 958798 complement(4256347..4256823) 1 NC_002655.2 iron storage protein; bacterioferritin 4256823 958798 Z4695 Escherichia coli O157:H7 str. EDL933 bacterioferritin NP_289884.1 4256347 R 155864 CDS NP_289885.1 15803851 961512 complement(4256896..4257090) 1 NC_002655.2 bacterioferritin-associated ferredoxin 4257090 yheA 961512 yheA Escherichia coli O157:H7 str. EDL933 bacterioferritin-associated ferredoxin NP_289885.1 4256896 R 155864 CDS NP_289886.1 15803852 958801 complement(4257273..4258457) 1 NC_002655.2 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 4258457 tuf 958801 tuf Escherichia coli O157:H7 str. EDL933 elongation factor Tu NP_289886.1 4257273 R 155864 CDS NP_289887.1 15803853 961515 complement(4258528..4260642) 1 NC_002655.2 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 4260642 fusA 961515 fusA Escherichia coli O157:H7 str. EDL933 elongation factor G NP_289887.1 4258528 R 155864 CDS NP_289888.1 15803854 958803 complement(4260739..4261209) 1 NC_002655.2 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 4261209 rpsG 958803 rpsG Escherichia coli O157:H7 str. EDL933 30S ribosomal protein S7 NP_289888.1 4260739 R 155864 CDS NP_289889.1 15803855 958802 complement(4261306..4261680) 1 NC_002655.2 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 4261680 rpsL 958802 rpsL Escherichia coli O157:H7 str. EDL933 30S ribosomal protein S12 NP_289889.1 4261306 R 155864 CDS NP_289890.1 15803856 961516 complement(4261806..4262093) 1 NC_002655.2 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusB 4262093 yheL 961516 yheL Escherichia coli O157:H7 str. EDL933 sulfur transfer complex subunit TusB NP_289890.1 4261806 R 155864 CDS NP_289891.1 15803857 958811 complement(4262101..4262460) 1 NC_002655.2 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur relay protein TusC 4262460 yheM 958811 yheM Escherichia coli O157:H7 str. EDL933 sulfur relay protein TusC NP_289891.1 4262101 R 155864 CDS NP_289892.1 15803858 961521 complement(4262460..4262846) 1 NC_002655.2 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD 4262846 yheN 961521 yheN Escherichia coli O157:H7 str. EDL933 sulfur transfer complex subunit TusD NP_289892.1 4262460 R 155864 CDS NP_289893.1 15803859 958804 complement(4262846..4263580) 1 NC_002655.2 hypothetical protein 4263580 yheO 958804 yheO Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289893.1 4262846 R 155864 CDS NP_289894.1 15803860 958444 complement(4263735..4264547) 1 NC_002655.2 rotamase; FKBP-type peptidylprolyl isomerase 4264547 fkpA 958444 fkpA Escherichia coli O157:H7 str. EDL933 FKBP-type peptidylprolyl isomerase NP_289894.1 4263735 R 155864 CDS NP_289895.1 15803861 961315 4264768..4264986 1 NC_002655.2 hypothetical protein 4264986 slyX 961315 slyX Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289895.1 4264768 D 155864 CDS NP_289896.1 15803862 961279 complement(4265035..4265625) 1 NC_002655.2 rotamase; FKBP-type peptidylprolyl isomerase 4265625 slyD 961279 slyD Escherichia coli O157:H7 str. EDL933 FKBP-type peptidylprolyl isomerase NP_289896.1 4265035 R 155864 CDS NP_289897.1 15803863 961297 complement(4265720..4265920) 1 NC_002655.2 No significant matches; hypothetical protein 4265920 961297 Z4708 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289897.1 4265720 R 155864 CDS NP_289898.1 15803864 958813 complement(4265957..4267735) 1 NC_002655.2 involved in potassium efflux; glutathione-regulated potassium-efflux system protein KefB 4267735 kefB 958813 kefB Escherichia coli O157:H7 str. EDL933 glutathione-regulated potassium-efflux system protein KefB NP_289898.1 4265957 R 155864 CDS NP_289899.1 15803865 961522 complement(4267735..4268289) 1 NC_002655.2 required for KefB activity; glutathione-regulated potassium-efflux system ancillary protein KefG 4268289 yheR 961522 yheR Escherichia coli O157:H7 str. EDL933 glutathione-regulated potassium-efflux system ancillary protein KefG NP_289899.1 4267735 R 155864 CDS NP_289900.1 15803866 958805 4268417..4270330 1 NC_002655.2 ABC transporter ATP-binding protein 4270330 yheS 958805 yheS Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_289900.1 4268417 D 155864 CDS NP_289901.1 15803867 958814 4270330..4271352 1 NC_002655.2 hydrolase 4271352 yheT 958814 yheT Escherichia coli O157:H7 str. EDL933 hydrolase NP_289901.1 4270330 D 155864 CDS NP_289902.1 15803868 958818 4271346..4271564 1 NC_002655.2 hypothetical protein 4271564 yheU 958818 yheU Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289902.1 4271346 D 155864 CDS NP_289903.1 15803869 958831 4271618..4272487 1 NC_002655.2 phosphoribulokinase 4272487 prkB 958831 prkB Escherichia coli O157:H7 str. EDL933 phosphoribulokinase NP_289903.1 4271618 D 155864 CDS NP_289904.1 15803870 958807 complement(4272542..4272946) 1 NC_002655.2 hypothetical protein 4272946 yhfA 958807 yhfA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289904.1 4272542 R 155864 CDS NP_289905.1 15803871 958797 4273248..4273880 1 NC_002655.2 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein 4273880 crp 958797 crp Escherichia coli O157:H7 str. EDL933 cAMP-regulatory protein NP_289905.1 4273248 D 155864 CDS NP_289906.1 15803872 958823 4273931..4276021 1 NC_002655.2 hypothetical protein 4276021 yhfK 958823 yhfK Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289906.1 4273931 D 155864 CDS NP_289907.1 15803873 961532 complement(4276088..4277308) 1 NC_002655.2 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate; bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase 4277308 argD 961532 argD Escherichia coli O157:H7 str. EDL933 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase NP_289907.1 4276088 R 155864 CDS NP_289908.1 15803874 958824 complement(4277394..4277957) 1 NC_002655.2 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 4277957 pabA 958824 pabA Escherichia coli O157:H7 str. EDL933 para-aminobenzoate synthase component II NP_289908.1 4277394 R 155864 CDS NP_289909.1 15803875 961531 complement(4277989..4278591) 1 NC_002655.2 cell filamentation protein Fic 4278591 fic 961531 fic Escherichia coli O157:H7 str. EDL933 cell filamentation protein Fic NP_289909.1 4277989 R 155864 CDS NP_289910.1 15803876 958827 complement(4278581..4278748) 1 NC_002655.2 hypothetical protein 4278748 yhfG 958827 yhfG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289910.1 4278581 R 155864 CDS NP_289911.1 15803877 961533 complement(4278853..4279425) 1 NC_002655.2 peptidyl-prolyl cis-trans isomerase A 4279425 ppiA 961533 ppiA Escherichia coli O157:H7 str. EDL933 peptidyl-prolyl cis-trans isomerase A NP_289911.1 4278853 R 155864 CDS NP_289912.1 15803878 958828 4279696..4280877 1 NC_002655.2 hypothetical protein 4280877 yhfC 958828 yhfC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289912.1 4279696 D 155864 CDS NP_289913.1 15803879 961534 4281139..4283682 1 NC_002655.2 nitrite reductase (NAD(P)H) subunit 4283682 nirB 961534 nirB Escherichia coli O157:H7 str. EDL933 nitrite reductase (NAD(P)H) subunit NP_289913.1 4281139 D 155864 CDS NP_289914.1 15803880 958830 4283679..4284005 1 NC_002655.2 involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations; nitrite reductase small subunit 4284005 nirD 958830 nirD Escherichia coli O157:H7 str. EDL933 nitrite reductase small subunit NP_289914.1 4283679 D 155864 CDS NP_289915.1 15805004 959621 4284131..4284937 1 NC_002655.2 member of the FNT family of formate and nitrite transporters; nitrite transporter NirC 4284937 nirC 959621 nirC Escherichia coli O157:H7 str. EDL933 nitrite transporter NirC NP_289915.1 4284131 D 155864 CDS NP_289916.1 15803881 961541 4284956..4286329 1 NC_002655.2 multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin; siroheme synthase 4286329 cysG 961541 cysG Escherichia coli O157:H7 str. EDL933 siroheme synthase NP_289916.1 4284956 D 155864 CDS NP_289917.1 15803882 958832 4286584..4286751 1 NC_002655.2 hypothetical protein 4286751 yhfL 958832 yhfL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289917.1 4286584 D 155864 CDS NP_289918.1 15803883 961536 4286996..4288384 1 NC_002655.2 inner membrane protein possibly involved in fructoselysine transport; member of the flr operon; fructoselysine transporter 4288384 frlA 961536 frlA Escherichia coli O157:H7 str. EDL933 fructoselysine transporter NP_289918.1 4286996 D 155864 CDS NP_289919.1 15803884 958541 4288384..4289427 1 NC_002655.2 catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine; fructoselysine-6-P-deglycase 4289427 frlB 958541 frlB Escherichia coli O157:H7 str. EDL933 fructoselysine-6-P-deglycase NP_289919.1 4288384 D 155864 CDS NP_289920.1 15803885 958833 4289478..4290305 1 NC_002655.2 YhfOP; YhfP; YhfO; FrlC; catalyzes the interconversion of fructoselysine and psicoselysine; fructoselysine 3-epimerase 4290305 958833 Z4733 Escherichia coli O157:H7 str. EDL933 fructoselysine 3-epimerase NP_289920.1 4289478 D 155864 CDS NP_289921.1 15804996 959642 4290302..4291090 1 NC_002655.2 fructoselysine 6-kinase 4291090 959642 Z4734m Escherichia coli O157:H7 str. EDL933 fructoselysine 6-kinase NP_289921.1 4290302 D 155864 CDS NP_289922.1 15803886 961538 4291124..4291921 1 NC_002655.2 may act as a transcriptional regulator of a fructoselysine-induced operon containing the yhfM, yhfN, yhfO, yhfP, yhfQ, and yhfR genes; DNA-binding transcriptional regulator FrlR 4291921 yhfR 961538 yhfR Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator FrlR NP_289922.1 4291124 D 155864 CDS NP_289923.1 15803887 958834 complement(4292052..4293056) 1 NC_002655.2 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 4293056 trpS 958834 trpS Escherichia coli O157:H7 str. EDL933 tryptophanyl-tRNA synthetase NP_289923.1 4292052 R 155864 CDS NP_289924.1 15803888 958842 complement(4293049..4293807) 1 NC_002655.2 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase 4293807 gph 958842 gph Escherichia coli O157:H7 str. EDL933 phosphoglycolate phosphatase NP_289924.1 4293049 R 155864 CDS NP_289925.1 15803889 961547 complement(4293800..4294477) 1 NC_002655.2 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 4294477 rpe 961547 rpe Escherichia coli O157:H7 str. EDL933 ribulose-phosphate 3-epimerase NP_289925.1 4293800 R 155864 CDS NP_289926.1 15803890 958843 complement(4294495..4295331) 1 NC_002655.2 DNA adenine methylase 4295331 dam 958843 dam Escherichia coli O157:H7 str. EDL933 DNA adenine methylase NP_289926.1 4294495 R 155864 CDS NP_289927.1 15803891 961560 complement(4295438..4296724) 1 NC_002655.2 hypothetical protein 4296724 damX 961560 damX Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289927.1 4295438 R 155864 CDS NP_289928.1 15803892 958849 complement(4296816..4297904) 1 NC_002655.2 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 4297904 aroB 958849 aroB Escherichia coli O157:H7 str. EDL933 3-dehydroquinate synthase NP_289928.1 4296816 R 155864 CDS NP_289929.2 161367509 961553 complement(4297961..4298482) 1 NC_002655.2 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I 4298482 aroK 961553 aroK Escherichia coli O157:H7 str. EDL933 shikimate kinase I NP_289929.2 4297961 R 155864 CDS NP_289930.1 15803894 958855 complement(4298883..4300121) 1 NC_002655.2 outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa; porin 4300121 hofQ 958855 hofQ Escherichia coli O157:H7 str. EDL933 porin NP_289930.1 4298883 R 155864 CDS NP_289931.1 15803895 958856 complement(4300033..4300476) 1 NC_002655.2 hypothetical protein 4300476 yrfA 958856 yrfA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289931.1 4300033 R 155864 CDS NP_289932.1 15803896 958865 complement(4300427..4300867) 1 NC_002655.2 hypothetical protein 4300867 yrfB 958865 yrfB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289932.1 4300427 R 155864 CDS NP_289933.1 15803897 958839 complement(4300851..4301390) 1 NC_002655.2 hypothetical protein 4301390 yrfC 958839 yrfC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289933.1 4300851 R 155864 CDS NP_289934.1 15803898 958826 complement(4301374..4302195) 1 NC_002655.2 hypothetical protein 4302195 yrfD 958826 yrfD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289934.1 4301374 R 155864 CDS NP_289935.2 228979043 958881 4302288..4304840 1 NC_002655.2 bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits; peptidoglycan synthetase 4304840 mrcA 958881 mrcA Escherichia coli O157:H7 str. EDL933 peptidoglycan synthetase NP_289935.2 4302288 D 155864 CDS NP_289936.1 15803900 958125 complement(4305005..4305565) 1 NC_002655.2 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose diphosphatase NudE 4305565 nudE 958125 nudE Escherichia coli O157:H7 str. EDL933 ADP-ribose diphosphatase NudE NP_289936.1 4305005 R 155864 CDS NP_289937.1 15803901 959306 4305885..4308020 1 NC_002655.2 dehydrogenase 4308020 yrfF 959306 yrfF Escherichia coli O157:H7 str. EDL933 dehydrogenase NP_289937.1 4305885 D 155864 CDS NP_289938.1 15803902 960875 4308040..4308753 1 NC_002655.2 phosphatase 4308753 yrfG 960875 yrfG Escherichia coli O157:H7 str. EDL933 phosphatase NP_289938.1 4308040 D 155864 CDS NP_289939.1 15803903 960872 4308764..4309165 1 NC_002655.2 ribosome-associated heat shock protein Hsp15 4309165 yrfH 960872 yrfH Escherichia coli O157:H7 str. EDL933 ribosome-associated heat shock protein Hsp15 NP_289939.1 4308764 D 155864 CDS NP_289940.2 161367508 958884 4309190..4310068 1 NC_002655.2 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; heat shock protein 33 4310068 hslO 958884 hslO Escherichia coli O157:H7 str. EDL933 heat shock protein 33 NP_289940.2 4309190 D 155864 CDS NP_289941.1 15803905 961582 complement(4310131..4311855) 1 NC_002655.2 transport 4311855 yhgE 961582 yhgE Escherichia coli O157:H7 str. EDL933 transport NP_289941.1 4310131 R 155864 CDS NP_289942.1 15803906 958888 complement(4311931..4312062) 1 NC_002655.2 No significant matches; hypothetical protein 4312062 958888 Z4757 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289942.1 4311931 R 155864 CDS NP_289943.1 15803907 958885 4312234..4313856 1 NC_002655.2 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 4313856 pckA 958885 pckA Escherichia coli O157:H7 str. EDL933 phosphoenolpyruvate carboxykinase NP_289943.1 4312234 D 155864 CDS NP_289944.1 15803908 959479 complement(4313932..4315284) 1 NC_002655.2 membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; osmolarity sensor protein 4315284 envZ 959479 envZ Escherichia coli O157:H7 str. EDL933 osmolarity sensor protein NP_289944.1 4313932 R 155864 CDS NP_289945.1 15803909 957766 complement(4315281..4316000) 1 NC_002655.2 part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; osmolarity response regulator 4316000 ompR 957766 ompR Escherichia coli O157:H7 str. EDL933 osmolarity response regulator NP_289945.1 4315281 R 155864 CDS NP_289946.2 161367507 958110 4316228..4316704 1 NC_002655.2 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB 4316704 greB 958110 greB Escherichia coli O157:H7 str. EDL933 transcription elongation factor GreB NP_289946.2 4316228 D 155864 CDS NP_289947.1 15803911 958889 4316900..4319122 1 NC_002655.2 hypothetical protein 4319122 yhgF 958889 yhgF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289947.1 4316900 D 155864 CDS NP_289948.1 15803912 957589 4319560..4319787 1 NC_002655.2 ferrous iron transport protein A 4319787 feoA 957589 feoA Escherichia coli O157:H7 str. EDL933 ferrous iron transport protein A NP_289948.1 4319560 D 155864 CDS NP_289949.1 15803913 957596 4319804..4322125 1 NC_002655.2 cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake; ferrous iron transport protein B 4322125 feoB 957596 feoB Escherichia coli O157:H7 str. EDL933 ferrous iron transport protein B NP_289949.1 4319804 D 155864 CDS NP_289950.1 15803914 958890 4322125..4322361 1 NC_002655.2 hypothetical protein 4322361 yhgG 958890 yhgG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289950.1 4322125 D 155864 CDS NP_289951.1 15803915 961581 4322564..4323442 1 NC_002655.2 hypothetical protein 4323442 yhgA 961581 yhgA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289951.1 4322564 D 155864 CDS NP_289952.1 15803916 958896 complement(4323469..4324239) 1 NC_002655.2 Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis; carboxylesterase BioH 4324239 bioH 958896 bioH Escherichia coli O157:H7 str. EDL933 carboxylesterase BioH NP_289952.1 4323469 R 155864 CDS NP_289953.2 161367506 958897 4324277..4324960 1 NC_002655.2 involved in high-affinity gluconate transport; gluconate periplasmic binding protein 4324960 yhgH 958897 yhgH Escherichia coli O157:H7 str. EDL933 gluconate periplasmic binding protein NP_289953.2 4324277 D 155864 CDS NP_289954.1 15803918 961586 4325019..4325594 1 NC_002655.2 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; DNA uptake protein 4325594 yhgI 961586 yhgI Escherichia coli O157:H7 str. EDL933 DNA uptake protein NP_289954.1 4325019 D 155864 CDS NP_289955.1 15803919 958902 4325955..4327271 1 NC_002655.2 high-affinity transport of gluconate / gluconate permease 4327271 gntT 958902 gntT Escherichia coli O157:H7 str. EDL933 high-affinity transport of gluconate / gluconate permease NP_289955.1 4325955 D 155864 CDS NP_289956.1 15803920 961590 complement(4327316..4329400) 1 NC_002655.2 amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 4329400 malQ 961590 malQ Escherichia coli O157:H7 str. EDL933 4-alpha-glucanotransferase NP_289956.1 4327316 R 155864 CDS NP_289957.1 15803921 958898 complement(4329410..4331803) 1 NC_002655.2 maltodextrin phosphorylase 4331803 malP 958898 malP Escherichia coli O157:H7 str. EDL933 maltodextrin phosphorylase NP_289957.1 4329410 R 155864 CDS NP_289958.1 15803922 961589 complement(4332063..4332164) 1 NC_002655.2 No significant matches; hypothetical protein 4332164 961589 Z4773 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289958.1 4332063 R 155864 CDS NP_289959.1 15803923 958900 4332415..4335120 1 NC_002655.2 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides; transcriptional regulator MalT 4335120 malT 958900 malT Escherichia coli O157:H7 str. EDL933 transcriptional regulator MalT NP_289959.1 4332415 D 155864 CDS NP_289960.1 15803924 958906 4335117..4335245 1 NC_002655.2 No significant matches; hypothetical protein 4335245 958906 Z4775 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289960.1 4335117 D 155864 CDS NP_289961.1 15803925 958926 4335181..4335465 1 NC_002655.2 hypothetical protein 4335465 958926 Z4776 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289961.1 4335181 D 155864 CDS NP_289962.1 15803926 961606 4335456..4335941 1 NC_002655.2 hypothetical protein 4335941 961606 Z4777 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289962.1 4335456 D 155864 CDS NP_289963.1 15803927 958908 complement(4335991..4337019) 1 NC_002655.2 catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester; RNA 3'-terminal-phosphate cyclase 4337019 958908 Z4778 Escherichia coli O157:H7 str. EDL933 RNA 3'-terminal-phosphate cyclase NP_289963.1 4335991 R 155864 CDS NP_289964.1 15803928 961595 complement(4337023..4338249) 1 NC_002655.2 hypothetical protein 4338249 rtcB 961595 rtcB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289964.1 4337023 R 155864 CDS NP_289965.1 15803929 958909 4338437..4340035 1 NC_002655.2 2-component regulator 4340035 rtcR 958909 rtcR Escherichia coli O157:H7 str. EDL933 2-component regulator NP_289965.1 4338437 D 155864 CDS NP_289966.1 15803930 961600 complement(4340017..4340775) 1 NC_002655.2 represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism; DNA-binding transcriptional repressor GlpR 4340775 glpR 961600 glpR Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional repressor GlpR NP_289966.1 4340017 R 155864 CDS NP_289967.1 15803931 958913 complement(4340792..4341622) 1 NC_002655.2 protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity; intramembrane serine protease GlpG 4341622 glpG 958913 glpG Escherichia coli O157:H7 str. EDL933 intramembrane serine protease GlpG NP_289967.1 4340792 R 155864 CDS NP_289968.1 15803932 961597 complement(4341667..4341993) 1 NC_002655.2 belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine; thiosulfate sulfurtransferase 4341993 glpE 961597 glpE Escherichia coli O157:H7 str. EDL933 thiosulfate sulfurtransferase NP_289968.1 4341667 R 155864 CDS NP_289969.1 15803933 958941 4342183..4343688 1 NC_002655.2 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; glycerol-3-phosphate dehydrogenase 4343688 glpD 958941 glpD Escherichia coli O157:H7 str. EDL933 glycerol-3-phosphate dehydrogenase NP_289969.1 4342183 D 155864 CDS NP_289970.1 15803934 961625 complement(4343903..4344505) 1 NC_002655.2 No significant matches; hypothetical protein 4344505 961625 Z4787 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289970.1 4343903 R 155864 CDS NP_289971.1 15803935 958875 complement(4344505..4345497) 1 NC_002655.2 hypothetical protein 4345497 958875 Z4788 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289971.1 4344505 R 155864 CDS NP_289972.1 15803936 958892 complement(4345523..4347031) 1 NC_002655.2 hypothetical protein 4347031 958892 Z4789 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289972.1 4345523 R 155864 CDS NP_289973.1 15803937 961619 complement(4347156..4349603) 1 NC_002655.2 glycogen phosphorylase 4349603 glgP 961619 glgP Escherichia coli O157:H7 str. EDL933 glycogen phosphorylase NP_289973.1 4347156 R 155864 CDS NP_289974.1 15803938 958927 complement(4349622..4351055) 1 NC_002655.2 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 4351055 glgA 958927 glgA Escherichia coli O157:H7 str. EDL933 glycogen synthase NP_289974.1 4349622 R 155864 CDS NP_289975.1 15803939 961608 complement(4351055..4352350) 1 NC_002655.2 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 4352350 glgC 961608 glgC Escherichia coli O157:H7 str. EDL933 glucose-1-phosphate adenylyltransferase NP_289975.1 4351055 R 155864 CDS NP_289976.1 15803940 958928 complement(4352368..4354341) 1 NC_002655.2 catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen; glycogen debranching protein 4354341 glgX 958928 glgX Escherichia coli O157:H7 str. EDL933 glycogen debranching protein NP_289976.1 4352368 R 155864 CDS NP_289977.1 15803941 961611 complement(4354338..4356524) 1 NC_002655.2 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein 4356524 glgB 961611 glgB Escherichia coli O157:H7 str. EDL933 glycogen branching protein NP_289977.1 4354338 R 155864 CDS NP_289978.1 15803942 958911 complement(4356797..4357900) 1 NC_002655.2 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 4357900 asd 958911 asd Escherichia coli O157:H7 str. EDL933 aspartate-semialdehyde dehydrogenase NP_289978.1 4356797 R 155864 CDS NP_289979.1 15803943 961596 4358092..4358685 1 NC_002655.2 YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP); dITP- and XTP- hydrolase 4358685 yhgN 961596 yhgN Escherichia coli O157:H7 str. EDL933 dITP- and XTP- hydrolase NP_289979.1 4358092 D 155864 CDS NP_289980.1 15803944 961622 complement(4358731..4360026) 1 NC_002655.2 DNA processing protein 4360026 961622 Z4799 Escherichia coli O157:H7 str. EDL933 DNA processing protein NP_289980.1 4358731 R 155864 CDS NP_289981.1 15803945 958957 complement(4360085..4361059) 1 NC_002655.2 ATP-dependent DNA helicase 4361059 958957 Z4801 Escherichia coli O157:H7 str. EDL933 ATP-dependent DNA helicase NP_289981.1 4360085 R 155864 CDS NP_289982.1 15803946 961639 complement(4361063..4361452) 1 NC_002655.2 ATP-dependent DNA helicase 4361452 961639 Z4802 Escherichia coli O157:H7 str. EDL933 ATP-dependent DNA helicase NP_289982.1 4361063 R 155864 CDS NP_289983.1 15803947 958942 complement(4361449..4362057) 1 NC_002655.2 ATP-dependent DNA helicase 4362057 958942 Z4803 Escherichia coli O157:H7 str. EDL933 ATP-dependent DNA helicase NP_289983.1 4361449 R 155864 CDS NP_289984.1 15803948 961623 complement(4362197..4363537) 1 NC_002655.2 low affinity gluconate transporter 4363537 gntU 961623 gntU Escherichia coli O157:H7 str. EDL933 low affinity gluconate transporter NP_289984.1 4362197 R 155864 CDS NP_289985.2 161367505 958944 complement(4363541..4364068) 1 NC_002655.2 thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate; gluconate kinase 4364068 gntK 958944 gntK Escherichia coli O157:H7 str. EDL933 gluconate kinase NP_289985.2 4363541 R 155864 CDS NP_289986.1 15803950 958943 complement(4364207..4365172) 1 NC_002655.2 gluconate (gnt) operon regulator 4365172 gntR 958943 gntR Escherichia coli O157:H7 str. EDL933 gluconate (gnt) operon regulator NP_289986.1 4364207 R 155864 CDS NP_289987.1 15803951 958953 complement(4365426..4366121) 1 NC_002655.2 hypothetical protein 4366121 yhhW 958953 yhhW Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289987.1 4365426 R 155864 CDS NP_289988.1 15803952 958972 complement(4366244..4367281) 1 NC_002655.2 dehydrogenase 4367281 yhhX 958972 yhhX Escherichia coli O157:H7 str. EDL933 dehydrogenase NP_289988.1 4366244 R 155864 CDS NP_289989.1 15803953 958937 4367627..4368103 1 NC_002655.2 YhhY; regulated by the fur regulator; unknown function; acetyltransferase YhhY 4368103 yhhY 958937 yhhY Escherichia coli O157:H7 str. EDL933 acetyltransferase YhhY NP_289989.1 4367627 D 155864 CDS NP_289990.1 15803954 961627 4368314..4369225 1 NC_002655.2 No significant matches; hypothetical protein 4369225 961627 Z4810 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289990.1 4368314 D 155864 CDS NP_289991.1 15803955 958938 complement(4369174..4369590) 1 NC_002655.2 No significant matches; hypothetical protein 4369590 958938 Z4811 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289991.1 4369174 R 155864 CDS NP_289992.1 15803956 961624 complement(4369960..4371705) 1 NC_002655.2 periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides; gamma-glutamyltranspeptidase 4371705 ggt 961624 ggt Escherichia coli O157:H7 str. EDL933 gamma-glutamyltranspeptidase NP_289992.1 4369960 R 155864 CDS NP_289993.1 15803957 958946 4371825..4372265 1 NC_002655.2 hypothetical protein 4372265 yhhA 958946 yhhA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289993.1 4371825 D 155864 CDS NP_289994.1 15803958 961626 complement(4372252..4372995) 1 NC_002655.2 hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate; glycerophosphodiester phosphodiesterase 4372995 ugpQ 961626 ugpQ Escherichia coli O157:H7 str. EDL933 glycerophosphodiester phosphodiesterase NP_289994.1 4372252 R 155864 CDS NP_289995.2 161367504 958956 complement(4372992..4374062) 1 NC_002655.2 part of the UgpABCE glycerol-3-phosphate uptake system; glycerol-3-phosphate transporter ATP-binding subunit 4374062 ugpC 958956 ugpC Escherichia coli O157:H7 str. EDL933 glycerol-3-phosphate transporter ATP-binding subunit NP_289995.2 4372992 R 155864 CDS NP_289996.1 15803960 961635 complement(4374064..4374909) 1 NC_002655.2 with UgpABC is involved in uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter membrane protein 4374909 ugpE 961635 ugpE Escherichia coli O157:H7 str. EDL933 glycerol-3-phosphate transporter membrane protein NP_289996.1 4374064 R 155864 CDS NP_289997.1 15803961 958958 complement(4374906..4375793) 1 NC_002655.2 with UgpEC is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter permease 4375793 ugpA 958958 ugpA Escherichia coli O157:H7 str. EDL933 glycerol-3-phosphate transporter permease NP_289997.1 4374906 R 155864 CDS NP_289998.1 15803962 961433 complement(4375892..4377208) 1 NC_002655.2 with UgpACE is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter periplasmic binding protein 4377208 ugpB 961433 ugpB Escherichia coli O157:H7 str. EDL933 glycerol-3-phosphate transporter periplasmic binding protein NP_289998.1 4375892 R 155864 CDS NP_289999.1 15803963 961431 complement(4377568..4378314) 1 NC_002655.2 No significant matches; hypothetical protein 4378314 961431 Z4823 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_289999.1 4377568 R 155864 CDS NP_290000.2 161367503 961424 complement(4378433..4379146) 1 NC_002655.2 with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit 4379146 livF 961424 livF Escherichia coli O157:H7 str. EDL933 leucine/isoleucine/valine transporter ATP-binding subunit NP_290000.2 4378433 R 155864 CDS NP_290001.1 15803965 961419 complement(4379148..4379915) 1 NC_002655.2 Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit 4379915 livG 961419 livG Escherichia coli O157:H7 str. EDL933 leucine/isoleucine/valine transporter ATP-binding subunit NP_290001.1 4379148 R 155864 CDS NP_290002.1 15803966 961384 complement(4379912..4381189) 1 NC_002655.2 Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter permease subunit 4381189 livM 961384 livM Escherichia coli O157:H7 str. EDL933 leucine/isoleucine/valine transporter permease subunit NP_290002.1 4379912 R 155864 CDS NP_290003.1 15803967 961373 complement(4381186..4382112) 1 NC_002655.2 LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter; branched-chain amino acid ABC transporter permease 4382112 livH 961373 livH Escherichia coli O157:H7 str. EDL933 branched-chain amino acid ABC transporter permease NP_290003.1 4381186 R 155864 CDS NP_290004.1 15803968 961368 complement(4382160..4383269) 1 NC_002655.2 high-affinity leucine-specific transport system; periplasmic binding protein 4383269 livK 961368 livK Escherichia coli O157:H7 str. EDL933 high-affinity leucine-specific transport system; periplasmic binding protein NP_290004.1 4382160 R 155864 CDS NP_290005.1 15803969 961363 4383693..4384076 1 NC_002655.2 hypothetical protein 4384076 yhhK 961363 yhhK Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290005.1 4383693 D 155864 CDS NP_290006.1 15803970 961361 complement(4384073..4384600) 1 NC_002655.2 hypothetical protein 4384600 961361 Z4832 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290006.1 4384073 R 155864 CDS NP_290007.1 15803971 961334 complement(4384607..4384873) 1 NC_002655.2 hypothetical protein 4384873 961334 Z4833 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290007.1 4384607 R 155864 CDS NP_290008.1 15803972 961332 complement(4385023..4386183) 1 NC_002655.2 high-affinity amino acid transport system; periplasmic binding protein 4386183 livJ 961332 livJ Escherichia coli O157:H7 str. EDL933 high-affinity amino acid transport system; periplasmic binding protein NP_290008.1 4385023 R 155864 CDS NP_290009.1 15803973 961306 complement(4386397..4387251) 1 NC_002655.2 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 4387251 rpoH 961306 rpoH Escherichia coli O157:H7 str. EDL933 RNA polymerase factor sigma-32 NP_290009.1 4386397 R 155864 CDS NP_290010.1 15803974 961301 complement(4387496..4388554) 1 NC_002655.2 ABC transporter, membrane protein; cell division protein FtsX 4388554 ftsX 961301 ftsX Escherichia coli O157:H7 str. EDL933 cell division protein FtsX NP_290010.1 4387496 R 155864 CDS NP_290011.1 15803975 961298 complement(4388547..4389215) 1 NC_002655.2 ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions; cell division protein FtsE 4389215 ftsE 961298 ftsE Escherichia coli O157:H7 str. EDL933 cell division protein FtsE NP_290011.1 4388547 R 155864 CDS NP_290012.1 15803976 961296 complement(4389218..4390714) 1 NC_002655.2 signal recognition protein receptor; functions in the targeting and insertion of membrane proteins; cell division protein FtsY 4390714 ftsY 961296 ftsY Escherichia coli O157:H7 str. EDL933 cell division protein FtsY NP_290012.1 4389218 R 155864 CDS NP_290013.1 15803977 961292 4390864..4391460 1 NC_002655.2 catalyzes the methylation of 16S rRNA at position G966; 16S rRNA m(2)G966-methyltransferase 4391460 rsmD 961292 rsmD Escherichia coli O157:H7 str. EDL933 16S rRNA m(2)G966-methyltransferase NP_290013.1 4390864 D 155864 CDS NP_290014.1 15803978 961289 4391450..4391719 1 NC_002655.2 hypothetical protein 4391719 yhhL 961289 yhhL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290014.1 4391450 D 155864 CDS NP_290015.1 15803979 961284 complement(4391722..4392081) 1 NC_002655.2 receptor 4392081 yhhM 961284 yhhM Escherichia coli O157:H7 str. EDL933 receptor NP_290015.1 4391722 R 155864 CDS NP_290016.1 15803980 961270 4392222..4392848 1 NC_002655.2 hypothetical protein 4392848 yhhN 961270 yhhN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290016.1 4392222 D 155864 CDS NP_290017.1 15803981 961265 4392922..4395120 1 NC_002655.2 P-type ATPase involved in the export of lead, cadmium, zinc and mercury; zinc/cadmium/mercury/lead-transporting ATPase 4395120 zntA 961265 zntA Escherichia coli O157:H7 str. EDL933 zinc/cadmium/mercury/lead-transporting ATPase NP_290017.1 4392922 D 155864 CDS NP_290018.1 15803982 961264 complement(4395222..4395467) 1 NC_002655.2 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA 4395467 yhhP 961264 yhhP Escherichia coli O157:H7 str. EDL933 sulfur transfer protein SirA NP_290018.1 4395222 R 155864 CDS NP_290019.1 15803983 961263 4395688..4396353 1 NC_002655.2 hypothetical protein 4396353 yhhQ 961263 yhhQ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290019.1 4395688 D 155864 CDS NP_290020.2 161367502 961260 4396426..4396983 1 NC_002655.2 hypothetical protein 4396983 961260 Z4846 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290020.2 4396426 D 155864 CDS NP_290021.2 161367501 961258 complement(4396987..4398204) 1 NC_002655.2 major facilitator superfamily transporter 4398204 yhhS 961258 yhhS Escherichia coli O157:H7 str. EDL933 major facilitator superfamily transporter NP_290021.2 4396987 R 155864 CDS NP_290022.1 15803986 961257 4398291..4399385 1 NC_002655.2 hypothetical protein 4399385 yhhT 961257 yhhT Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290022.1 4398291 D 155864 CDS NP_290023.1 15803987 961255 4399765..4400154 1 NC_002655.2 No significant matches; hypothetical protein 4400154 961255 Z4849 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290023.1 4399765 D 155864 CDS NP_290024.1 15803988 961254 4400223..4401281 1 NC_002655.2 O-methyltransferase 4401281 961254 Z4850 Escherichia coli O157:H7 str. EDL933 O-methyltransferase NP_290024.1 4400223 D 155864 CDS NP_290025.1 15803989 961253 4401322..4402044 1 NC_002655.2 No significant matches; hypothetical protein 4402044 961253 Z4851 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290025.1 4401322 D 155864 CDS NP_290026.1 15803990 961252 4402041..4402862 1 NC_002655.2 phospholipid biosynthesis acyltransferase 4402862 961252 Z4852 Escherichia coli O157:H7 str. EDL933 phospholipid biosynthesis acyltransferase NP_290026.1 4402041 D 155864 CDS NP_290027.1 15803991 961251 4402837..4403094 1 NC_002655.2 acyl carrier protein 4403094 961251 Z4853 Escherichia coli O157:H7 str. EDL933 acyl carrier protein NP_290027.1 4402837 D 155864 CDS NP_290028.1 15803992 961250 4403106..4403357 1 NC_002655.2 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 4403357 961250 Z4854 Escherichia coli O157:H7 str. EDL933 acyl carrier protein NP_290028.1 4403106 D 155864 CDS NP_290029.1 15803993 961249 4403362..4403943 1 NC_002655.2 hypothetical protein 4403943 961249 Z4855 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290029.1 4403362 D 155864 CDS NP_290030.1 15803994 961248 4403940..4405301 1 NC_002655.2 hypothetical protein 4405301 961248 Z4856 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290030.1 4403940 D 155864 CDS NP_290031.1 15803995 961247 4405288..4405641 1 NC_002655.2 No significant matches; hypothetical protein 4405641 961247 Z4857 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290031.1 4405288 D 155864 CDS NP_290032.1 15803996 961246 4405632..4407308 1 NC_002655.2 hypothetical protein 4407308 961246 Z4858 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290032.1 4405632 D 155864 CDS NP_290033.1 15803997 961245 4407312..4407734 1 NC_002655.2 hypothetical protein 4407734 961245 Z4859 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290033.1 4407312 D 155864 CDS NP_290034.1 15803998 961244 4407731..4408336 1 NC_002655.2 No significant matches; hypothetical protein 4408336 961244 Z4860 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290034.1 4407731 D 155864 CDS NP_290035.1 15803999 961243 4408305..4410623 1 NC_002655.2 hypothetical protein 4410623 961243 Z4861 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290035.1 4408305 D 155864 CDS NP_290036.1 15804000 961242 4410620..4411204 1 NC_002655.2 No significant matches; hypothetical protein 4411204 961242 Z4862 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290036.1 4410620 D 155864 CDS NP_290037.1 15804001 961241 4411206..4412375 1 NC_002655.2 FabB; beta-ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 4412375 961241 Z4863 Escherichia coli O157:H7 str. EDL933 3-oxoacyl-ACP synthase NP_290037.1 4411206 D 155864 CDS NP_290038.1 15804002 961240 4412372..4412836 1 NC_002655.2 hypothetical protein 4412836 961240 Z4864 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290038.1 4412372 D 155864 CDS NP_290039.1 15804003 961239 4412836..4413567 1 NC_002655.2 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 4413567 fabG 961239 fabG Escherichia coli O157:H7 str. EDL933 3-ketoacyl-ACP reductase NP_290039.1 4412836 D 155864 CDS NP_290040.1 15804004 961238 4413564..4414793 1 NC_002655.2 FabB; beta-ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 4414793 961238 Z4866 Escherichia coli O157:H7 str. EDL933 3-oxoacyl-ACP synthase NP_290040.1 4413564 D 155864 CDS NP_290041.1 15804005 961237 4414795..4415382 1 NC_002655.2 holo-(acyl carrier protein) synthase 2 4415382 961237 Z4867 Escherichia coli O157:H7 str. EDL933 holo-(acyl carrier protein) synthase 2 NP_290041.1 4414795 D 155864 CDS NP_290042.1 15804006 961236 4415493..4417067 1 NC_002655.2 periplasmic binding protein for nickel 4417067 nikA 961236 nikA Escherichia coli O157:H7 str. EDL933 periplasmic binding protein for nickel NP_290042.1 4415493 D 155864 CDS NP_290043.1 15804007 961235 4417067..4418011 1 NC_002655.2 with NikACDE is involved in nickel transport into the cell; nickel transporter permease NikB 4418011 nikB 961235 nikB Escherichia coli O157:H7 str. EDL933 nickel transporter permease NikB NP_290043.1 4417067 D 155864 CDS NP_290044.1 15804008 961234 4418008..4418841 1 NC_002655.2 with NikABDE is involved in nickel transport into the cell; nickel transporter permease NikC 4418841 nikC 961234 nikC Escherichia coli O157:H7 str. EDL933 nickel transporter permease NikC NP_290044.1 4418008 D 155864 CDS NP_290045.1 15804009 961233 4418841..4419605 1 NC_002655.2 with NikABCE is involved in nickel transport into the cell; nickel transporter ATP-binding protein NikD 4419605 nikD 961233 nikD Escherichia coli O157:H7 str. EDL933 nickel transporter ATP-binding protein NikD NP_290045.1 4418841 D 155864 CDS NP_290046.1 15804010 961232 4419602..4420408 1 NC_002655.2 with NikABCD is involved with nickel transport into the cell; nickel transporter ATP-binding protein NikE 4420408 nikE 961232 nikE Escherichia coli O157:H7 str. EDL933 nickel transporter ATP-binding protein NikE NP_290046.1 4419602 D 155864 CDS NP_290047.1 15804011 961231 4420414..4420815 1 NC_002655.2 Inhibits transcription at high concentrations of nickel; nickel responsive regulator 4420815 yhhG 961231 yhhG Escherichia coli O157:H7 str. EDL933 nickel responsive regulator NP_290047.1 4420414 D 155864 CDS NP_290048.1 15804012 961229 4421005..4421760 1 NC_002655.2 regulator 4421760 961229 Z4874 Escherichia coli O157:H7 str. EDL933 regulator NP_290048.1 4421005 D 155864 CDS NP_290049.1 15804013 961228 4421785..4422258 1 NC_002655.2 phosphotransferase system enzyme subunit 4422258 961228 Z4875 Escherichia coli O157:H7 str. EDL933 phosphotransferase system enzyme subunit NP_290049.1 4421785 D 155864 CDS NP_290050.1 15804014 961227 4422255..4422536 1 NC_002655.2 phosphotransferase system enzyme subunit 4422536 961227 Z4876 Escherichia coli O157:H7 str. EDL933 phosphotransferase system enzyme subunit NP_290050.1 4422255 D 155864 CDS NP_290051.1 15804015 961226 4422583..4423971 1 NC_002655.2 phosphotransferase system enzyme subunit 4423971 961226 Z4877 Escherichia coli O157:H7 str. EDL933 phosphotransferase system enzyme subunit NP_290051.1 4422583 D 155864 CDS NP_290052.1 15804016 961225 4423964..4425472 1 NC_002655.2 xylulose kinase 4425472 961225 Z4878 Escherichia coli O157:H7 str. EDL933 xylulose kinase NP_290052.1 4423964 D 155864 CDS NP_290053.1 15804017 961223 4425462..4425731 1 NC_002655.2 phosphocarrier protein 4425731 961223 Z4879 Escherichia coli O157:H7 str. EDL933 phosphocarrier protein NP_290053.1 4425462 D 155864 CDS NP_290054.1 15804018 961222 4425764..4426624 1 NC_002655.2 class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis; fructose-1,6-bisphosphate aldolase 4426624 gatY 961222 gatY Escherichia coli O157:H7 str. EDL933 fructose-1,6-bisphosphate aldolase NP_290054.1 4425764 D 155864 CDS NP_290055.1 15804019 961220 complement(4426674..4427033) 1 NC_002655.2 No significant matches; hypothetical protein 4427033 961220 Z4882 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290055.1 4426674 R 155864 CDS NP_290056.1 15804020 961218 complement(4427030..4427305) 1 NC_002655.2 No significant matches; hypothetical protein 4427305 961218 Z4883 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290056.1 4427030 R 155864 CDS NP_290057.1 15804021 961216 complement(4427378..4428505) 1 NC_002655.2 transporter 4428505 yhhJ 961216 yhhJ Escherichia coli O157:H7 str. EDL933 transporter NP_290057.1 4427378 R 155864 CDS NP_290058.1 15804022 961214 complement(4428502..4431186) 1 NC_002655.2 ABC transporter ATP-binding protein, fragment 1 4431186 yhiH 961214 yhiH Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein, fragment 1 NP_290058.1 4428502 R 155864 CDS NP_290059.1 15804023 961213 complement(4431234..4432301) 1 NC_002655.2 hypothetical protein 4432301 yhiI 961213 yhiI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290059.1 4431234 R 155864 CDS NP_290060.1 15804024 961212 complement(4432667..4434289) 1 NC_002655.2 hypothetical protein 4434289 yhiJ 961212 yhiJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290060.1 4432667 R 155864 CDS NP_290061.1 15804025 961211 complement(4434551..4436224) 1 NC_002655.2 hypothetical protein 4436224 961211 Z4888 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290061.1 4434551 R 155864 CDS NP_290062.1 15804026 961210 4436447..4437598 1 NC_002655.2 hypothetical protein 4437598 yhiM 961210 yhiM Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290062.1 4436447 D 155864 CDS NP_290063.1 15804027 961209 complement(4437916..4439118) 1 NC_002655.2 hypothetical protein 4439118 yhiN 961209 yhiN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290063.1 4437916 R 155864 CDS NP_290064.1 15804028 961208 4439351..4440850 1 NC_002655.2 low-affinity phosphate transport protein 4440850 pitA 961208 pitA Escherichia coli O157:H7 str. EDL933 low-affinity phosphate transport protein NP_290064.1 4439351 D 155864 CDS NP_290065.1 15804029 961207 complement(4440921..4441256) 1 NC_002655.2 ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspB 4441256 yhiO 961207 yhiO Escherichia coli O157:H7 str. EDL933 universal stress protein UspB NP_290065.1 4440921 R 155864 CDS NP_290066.1 15804030 961205 4441648..4442082 1 NC_002655.2 universal stress protein; broad regulatory function? 4442082 uspA 961205 uspA Escherichia coli O157:H7 str. EDL933 universal stress protein; broad regulatory function? NP_290066.1 4441648 D 155864 CDS NP_290067.1 15804031 961204 4442399..4443868 1 NC_002655.2 member of the POT family of peptide transporters; probable proton-dependent peptide transporter function; inner membrane transporter YhiP 4443868 yhiP 961204 yhiP Escherichia coli O157:H7 str. EDL933 inner membrane transporter YhiP NP_290067.1 4442399 D 155864 CDS NP_290068.1 15804032 961201 complement(4443917..4444669) 1 NC_002655.2 predicted SAM-dependent methyltransferase; methyltransferase 4444669 yhiQ 961201 yhiQ Escherichia coli O157:H7 str. EDL933 methyltransferase NP_290068.1 4443917 R 155864 CDS NP_290069.1 15804033 961200 complement(4444677..4446719) 1 NC_002655.2 oligopeptidase A 4446719 prlC 961200 prlC Escherichia coli O157:H7 str. EDL933 oligopeptidase A NP_290069.1 4444677 R 155864 CDS NP_290070.1 15804034 961199 4446922..4447764 1 NC_002655.2 hypothetical protein 4447764 yhiR 961199 yhiR Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290070.1 4446922 D 155864 CDS NP_290071.1 15804035 961197 4447836..4449188 1 NC_002655.2 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 4449188 gor 961197 gor Escherichia coli O157:H7 str. EDL933 glutathione reductase NP_290071.1 4447836 D 155864 CDS NP_290072.1 15804036 961196 4450069..4450422 1 NC_002655.2 regulates the expression of of the arsRBC involved in resistance to arsenic; ArsR family transcriptional regulator 4450422 arsR 961196 arsR Escherichia coli O157:H7 str. EDL933 ArsR family transcriptional regulator NP_290072.1 4450069 D 155864 CDS NP_290073.1 15804037 961195 4450476..4451765 1 NC_002655.2 arsenical pump membrane protein 4451765 arsB 961195 arsB Escherichia coli O157:H7 str. EDL933 arsenical pump membrane protein NP_290073.1 4450476 D 155864 CDS NP_290074.1 15804038 961191 4451778..4452203 1 NC_002655.2 arsenate reductase 4452203 arsC 961191 arsC Escherichia coli O157:H7 str. EDL933 arsenate reductase NP_290074.1 4451778 D 155864 CDS NP_290075.1 15804039 961189 4452315..4452422 1 NC_002655.2 No significant matches; hypothetical protein 4452422 961189 Z4906 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290075.1 4452315 D 155864 CDS NP_290076.1 15804040 961188 4452831..4453946 1 NC_002655.2 hypothetical protein 4453946 961188 Z4907 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290076.1 4452831 D 155864 CDS NP_290077.1 15804041 961185 4454268..4454867 1 NC_002655.2 hypothetical protein 4454867 slp 961185 slp Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290077.1 4454268 D 155864 CDS NP_290078.1 15804042 961181 4455023..4455553 1 NC_002655.2 hypothetical protein 4455553 yhiF 961181 yhiF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290078.1 4455023 D 155864 CDS NP_290079.1 15804043 961177 complement(4455614..4456642) 1 NC_002655.2 heme/hemoglobin transport protein 4456642 chuS 961177 chuS Escherichia coli O157:H7 str. EDL933 heme/hemoglobin transport protein NP_290079.1 4455614 R 155864 CDS NP_290080.1 15804044 961176 complement(4456691..4458673) 1 NC_002655.2 outer membrane heme/hemoglobin receptor 4458673 chuA 961176 chuA Escherichia coli O157:H7 str. EDL933 outer membrane heme/hemoglobin receptor NP_290080.1 4456691 R 155864 CDS NP_290081.1 15804045 961172 complement(4458949..4459233) 1 NC_002655.2 No significant matches; hypothetical protein 4459233 961172 Z4912 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290081.1 4458949 R 155864 CDS NP_290082.1 15804046 961171 4459356..4460270 1 NC_002655.2 periplasmic binding protein 4460270 chuT 961171 chuT Escherichia coli O157:H7 str. EDL933 periplasmic binding protein NP_290082.1 4459356 D 155864 CDS NP_290083.1 15804047 961167 4460290..4461627 1 NC_002655.2 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 4461627 chuW 961167 chuW Escherichia coli O157:H7 str. EDL933 coproporphyrinogen III oxidase NP_290083.1 4460290 D 155864 CDS NP_290084.1 15804048 961164 4461640..4462134 1 NC_002655.2 hypothetical protein 4462134 chuX 961164 chuX Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290084.1 4461640 D 155864 CDS NP_290085.1 15804049 961163 4462134..4462757 1 NC_002655.2 hypothetical protein 4462757 chuY 961163 chuY Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290085.1 4462134 D 155864 CDS NP_290086.1 15804050 961162 4462806..4463798 1 NC_002655.2 permease of iron compound ABC transport system 4463798 chuU 961162 chuU Escherichia coli O157:H7 str. EDL933 permease of iron compound ABC transport system NP_290086.1 4462806 D 155864 CDS NP_290087.1 15804051 961161 4463795..4464565 1 NC_002655.2 with HmuTU is involved in the transport of hemin; hemin importer ATP-binding subunit 4464565 hmuV 961161 hmuV Escherichia coli O157:H7 str. EDL933 hemin importer ATP-binding subunit NP_290087.1 4463795 D 155864 CDS NP_290088.1 15804052 961160 complement(4464617..4465264) 1 NC_002655.2 inner membrane protein involved in cell density-dependent acid resistance; part of the acid fitness island (AFI) of E. coli; Mg(2+) transport ATPase 4465264 yhiD 961160 yhiD Escherichia coli O157:H7 str. EDL933 Mg(2+) transport ATPase NP_290088.1 4464617 R 155864 CDS NP_290089.1 15804053 961159 complement(4465328..4465666) 1 NC_002655.2 acid-resistance protein 4465666 hdeB 961159 hdeB Escherichia coli O157:H7 str. EDL933 acid-resistance protein NP_290089.1 4465328 R 155864 CDS NP_290090.1 15804054 961158 complement(4465770..4466102) 1 NC_002655.2 inactive form; acid-resistance protein 4466102 hdeA 961158 hdeA Escherichia coli O157:H7 str. EDL933 acid-resistance protein NP_290090.1 4465770 R 155864 CDS NP_290091.1 15804055 961157 4466357..4466929 1 NC_002655.2 acid-resistance membrane protein 4466929 hdeD 961157 hdeD Escherichia coli O157:H7 str. EDL933 acid-resistance membrane protein NP_290091.1 4466357 D 155864 CDS NP_290092.1 15804056 961156 4467728..4468255 1 NC_002655.2 hypothetical protein 4468255 yhiE 961156 yhiE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290092.1 4467728 D 155864 CDS NP_290093.1 15804057 961155 4468594..4469751 1 NC_002655.2 with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds; multidrug efflux system protein MdtE 4469751 yhiU 961155 yhiU Escherichia coli O157:H7 str. EDL933 multidrug efflux system protein MdtE NP_290093.1 4468594 D 155864 CDS NP_290094.1 15804058 961153 4469776..4472889 1 NC_002655.2 transport system permease 4472889 yhiV 961153 yhiV Escherichia coli O157:H7 str. EDL933 transport system permease NP_290094.1 4469776 D 155864 CDS NP_290095.1 15804059 961148 complement(4473252..4473980) 1 NC_002655.2 AraC family transcriptional regulator 4473980 yhiW 961148 yhiW Escherichia coli O157:H7 str. EDL933 AraC family transcriptional regulator NP_290095.1 4473252 R 155864 CDS NP_290096.1 15804060 961146 complement(4474348..4475172) 1 NC_002655.2 regulates genes in response to acid and/or during stationary phase; DNA-binding transcriptional regulator GadX 4475172 yhiX 961146 yhiX Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator GadX NP_290096.1 4474348 R 155864 CDS NP_290097.1 15804061 961141 complement(4475543..4476943) 1 NC_002655.2 glutamate decarboxylase 4476943 gadA 961141 gadA Escherichia coli O157:H7 str. EDL933 glutamate decarboxylase NP_290097.1 4475543 R 155864 CDS NP_290098.1 15804062 961135 complement(4477154..4478551) 1 NC_002655.2 cytochrome C peroxidase 4478551 yhjA 961135 yhjA Escherichia coli O157:H7 str. EDL933 cytochrome C peroxidase NP_290098.1 4477154 R 155864 CDS NP_290099.1 15804063 961133 4478956..4480605 1 NC_002655.2 cytoplasmic; catalyzes the hydrolysis of trehalose to glucose; trehalase 4480605 treF 961133 treF Escherichia coli O157:H7 str. EDL933 trehalase NP_290099.1 4478956 D 155864 CDS NP_290100.1 15804064 961122 complement(4480656..4481258) 1 NC_002655.2 regulator 4481258 yhjB 961122 yhjB Escherichia coli O157:H7 str. EDL933 regulator NP_290100.1 4480656 R 155864 CDS NP_290101.1 15804065 961121 4481706..4482677 1 NC_002655.2 LysR family transcriptional regulator 4482677 yhjC 961121 yhjC Escherichia coli O157:H7 str. EDL933 LysR family transcriptional regulator NP_290101.1 4481706 D 155864 CDS NP_290102.1 15804066 961112 4482726..4483739 1 NC_002655.2 hypothetical protein 4483739 yhjD 961112 yhjD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290102.1 4482726 D 155864 CDS NP_290103.1 15804067 961102 4484151..4485473 1 NC_002655.2 transporter 4485473 yhjE 961102 yhjE Escherichia coli O157:H7 str. EDL933 transporter NP_290103.1 4484151 D 155864 CDS NP_290104.1 15804068 961097 complement(4485655..4487730) 1 NC_002655.2 hypothetical protein 4487730 yhjG 961097 yhjG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290104.1 4485655 R 155864 CDS NP_290105.1 15804069 961095 complement(4487785..4488552) 1 NC_002655.2 in Escherichia coli this protein is involved in flagellar function; diguanylate phosphodiesterase 4488552 yhjH 961095 yhjH Escherichia coli O157:H7 str. EDL933 diguanylate phosphodiesterase NP_290105.1 4487785 R 155864 CDS NP_290106.1 15804070 961094 4488565..4489713 1 NC_002655.2 2-dehydro-3-deoxygluconokinase 4489713 kdgK 961094 kdgK Escherichia coli O157:H7 str. EDL933 2-dehydro-3-deoxygluconokinase NP_290106.1 4488565 D 155864 CDS NP_290107.1 15804071 961093 complement(4489809..4491305) 1 NC_002655.2 hypothetical protein 4491305 yhjJ 961093 yhjJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290107.1 4489809 R 155864 CDS NP_290108.1 15804072 961092 complement(4491526..4492812) 1 NC_002655.2 involved in the transport of C4-dicarboxylates across the membrane; C4-dicarboxylate transporter DctA 4492812 dctA 961092 dctA Escherichia coli O157:H7 str. EDL933 C4-dicarboxylate transporter DctA NP_290108.1 4491526 R 155864 CDS NP_290109.1 15804073 961091 complement(4492995..4494950) 1 NC_002655.2 HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a phosphodiesterase from E. coli; phosphodiesterase 4494950 yhjK 961091 yhjK Escherichia coli O157:H7 str. EDL933 phosphodiesterase NP_290109.1 4492995 R 155864 CDS NP_290110.1 15804991 959625 complement(join(4495065..4498139,4498139..4498528)) 1 NC_002655.2 cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA; cellulose synthase subunit BcsC 4498528 yhjL 959625 yhjL Escherichia coli O157:H7 str. EDL933 cellulose synthase subunit BcsC NP_290110.1 4495065 R 155864 CDS NP_290111.1 15804074 961090 complement(4498510..4499616) 1 NC_002655.2 catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; endo-1,4-D-glucanase 4499616 yhjM 961090 yhjM Escherichia coli O157:H7 str. EDL933 endo-1,4-D-glucanase NP_290111.1 4498510 R 155864 CDS NP_290112.2 157267373 961088 complement(4499623..4501950) 1 NC_002655.2 binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP); cellulose synthase regulator protein 4501950 yhjN 961088 yhjN Escherichia coli O157:H7 str. EDL933 cellulose synthase regulator protein NP_290112.2 4499623 R 155864 CDS NP_290113.2 161367500 961086 complement(4501991..4504609) 1 NC_002655.2 polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis; cellulose synthase catalytic subunit 4504609 bcsA 961086 bcsA Escherichia coli O157:H7 str. EDL933 cellulose synthase catalytic subunit NP_290113.2 4501991 R 155864 CDS NP_290114.1 15804997 959641 complement(4504606..4505358) 1 NC_002655.2 cell division protein 4505358 959641 Z4950m Escherichia coli O157:H7 str. EDL933 cell division protein NP_290114.1 4504606 R 155864 CDS NP_290115.1 15804077 961085 complement(4505370..4505558) 1 NC_002655.2 hypothetical protein 4505558 yhjR 961085 yhjR Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290115.1 4505370 R 155864 CDS NP_290116.1 15804078 961084 4505831..4507402 1 NC_002655.2 protease 4507402 yhjS 961084 yhjS Escherichia coli O157:H7 str. EDL933 protease NP_290116.1 4505831 D 155864 CDS NP_290117.1 15804079 961083 4507402..4507590 1 NC_002655.2 hypothetical protein 4507590 yhjT 961083 yhjT Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290117.1 4507402 D 155864 CDS NP_290118.1 15804080 961082 4507587..4509266 1 NC_002655.2 hypothetical protein 4509266 yhjU 961082 yhjU Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290118.1 4507587 D 155864 CDS NP_290119.1 15804081 961081 complement(4509353..4509595) 1 NC_002655.2 No significant matches; hypothetical protein 4509595 961081 Z4955 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290119.1 4509353 R 155864 CDS NP_290120.1 15804082 961080 4509936..4511207 1 NC_002655.2 transporter protein 4511207 yhjV 961080 yhjV Escherichia coli O157:H7 str. EDL933 transporter protein NP_290120.1 4509936 D 155864 CDS NP_290121.1 15804083 961079 complement(4511237..4512241) 1 NC_002655.2 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide transporter ATP-binding subunit 4512241 dppF 961079 dppF Escherichia coli O157:H7 str. EDL933 dipeptide transporter ATP-binding subunit NP_290121.1 4511237 R 155864 CDS NP_290122.1 15804084 961077 complement(4512238..4513221) 1 NC_002655.2 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide transporter ATP-binding subunit 4513221 dppD 961077 dppD Escherichia coli O157:H7 str. EDL933 dipeptide transporter ATP-binding subunit NP_290122.1 4512238 R 155864 CDS NP_290123.1 15804085 961076 complement(4513232..4514134) 1 NC_002655.2 dipeptide transporter 4514134 dppC 961076 dppC Escherichia coli O157:H7 str. EDL933 dipeptide transporter NP_290123.1 4513232 R 155864 CDS NP_290124.1 15804086 961075 complement(4514144..4515163) 1 NC_002655.2 transports peptides consisting of two or three amino acids; dipeptide transporter permease DppB 4515163 dppB 961075 dppB Escherichia coli O157:H7 str. EDL933 dipeptide transporter permease DppB NP_290124.1 4514144 R 155864 CDS NP_290125.1 15804087 961074 complement(4515314..4516921) 1 NC_002655.2 dipeptide transport protein 4516921 dppA 961074 dppA Escherichia coli O157:H7 str. EDL933 dipeptide transport protein NP_290125.1 4515314 R 155864 CDS NP_290126.2 161367499 961072 complement(4517834..4519525) 1 NC_002655.2 catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide; phosphoethanolamine transferase 4519525 yhjW 961072 yhjW Escherichia coli O157:H7 str. EDL933 phosphoethanolamine transferase NP_290126.2 4517834 R 155864 CDS NP_290127.1 15804089 961071 complement(4519782..4520312) 1 NC_002655.2 fimbrial subunit 4520312 961071 Z4965 Escherichia coli O157:H7 str. EDL933 fimbrial subunit NP_290127.1 4519782 R 155864 CDS NP_290128.1 15804090 961070 complement(4520317..4521372) 1 NC_002655.2 fimbrial protein 4521372 961070 Z4966 Escherichia coli O157:H7 str. EDL933 fimbrial protein NP_290128.1 4520317 R 155864 CDS NP_290129.1 15804998 959640 complement(4521387..4523960) 1 NC_002655.2 PapC-like porin protein involved in fimbrial biogenesis 4523960 959640 Z4968m Escherichia coli O157:H7 str. EDL933 PapC-like porin protein involved in fimbrial biogenesis NP_290129.1 4521387 R 155864 CDS NP_290130.1 15804091 961069 complement(4523989..4524687) 1 NC_002655.2 fimbrial chaperone 4524687 961069 Z4969 Escherichia coli O157:H7 str. EDL933 fimbrial chaperone NP_290130.1 4523989 R 155864 CDS NP_290131.1 15804092 961068 complement(4524740..4525276) 1 NC_002655.2 major fimbrial subunit 4525276 961068 Z4971 Escherichia coli O157:H7 str. EDL933 major fimbrial subunit NP_290131.1 4524740 R 155864 CDS NP_290132.1 15804093 961067 complement(4525608..4526810) 1 NC_002655.2 resistance protein 4526810 yhjX 961067 yhjX Escherichia coli O157:H7 str. EDL933 resistance protein NP_290132.1 4525608 R 155864 CDS NP_290133.1 15804094 961065 complement(4527039..4527743) 1 NC_002655.2 lipase 4527743 yhjY 961065 yhjY Escherichia coli O157:H7 str. EDL933 lipase NP_290133.1 4527039 R 155864 CDS NP_290134.1 15804095 961064 4527895..4528458 1 NC_002655.2 constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine; 3-methyladenine DNA glycosylase 4528458 tag 961064 tag Escherichia coli O157:H7 str. EDL933 3-methyladenine DNA glycosylase NP_290134.1 4527895 D 155864 CDS NP_290135.1 15804096 961063 4528455..4528895 1 NC_002655.2 hypothetical protein 4528895 yiaC 961063 yiaC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290135.1 4528455 D 155864 CDS NP_290136.1 15804097 961062 complement(4528864..4531083) 1 NC_002655.2 biotin sulfoxide reductase 4531083 bisC 961062 bisC Escherichia coli O157:H7 str. EDL933 biotin sulfoxide reductase NP_290136.1 4528864 R 155864 CDS NP_290137.1 15804098 961061 4531350..4532009 1 NC_002655.2 outer membrane lipoprotein 4532009 yiaD 961061 yiaD Escherichia coli O157:H7 str. EDL933 outer membrane lipoprotein NP_290137.1 4531350 D 155864 CDS NP_290138.2 161367498 961060 4532113..4533087 1 NC_002655.2 Involved in the metabolism of aromatic amino acids; 2-hydroxyacid dehydrogenase 4533087 yiaE 961060 yiaE Escherichia coli O157:H7 str. EDL933 2-hydroxyacid dehydrogenase NP_290138.2 4532113 D 155864 CDS NP_290139.1 15804100 961058 complement(4533137..4533967) 1 NC_002655.2 hypothetical protein 4533967 yiaF 961058 yiaF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290139.1 4533137 R 155864 CDS NP_290140.1 15804101 961057 4534281..4534571 1 NC_002655.2 transcriptional regulator 4534571 yiaG 961057 yiaG Escherichia coli O157:H7 str. EDL933 transcriptional regulator NP_290140.1 4534281 D 155864 CDS NP_290141.1 15804102 961056 4534852..4535064 1 NC_002655.2 cold-shock protein 4535064 cspA 961056 cspA Escherichia coli O157:H7 str. EDL933 cold-shock protein NP_290141.1 4534852 D 155864 CDS NP_290142.1 15804103 961054 complement(4535252..4535464) 1 NC_002655.2 small toxic polypeptide 4535464 961054 Z4982 Escherichia coli O157:H7 str. EDL933 small toxic polypeptide NP_290142.1 4535252 R 155864 CDS NP_290143.1 15804104 961053 complement(4535727..4537796) 1 NC_002655.2 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 4537796 glyS 961053 glyS Escherichia coli O157:H7 str. EDL933 glycyl-tRNA synthetase subunit beta NP_290143.1 4535727 R 155864 CDS NP_290144.1 15804105 961052 complement(4537806..4538717) 1 NC_002655.2 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 4538717 glyQ 961052 glyQ Escherichia coli O157:H7 str. EDL933 glycyl-tRNA synthetase subunit alpha NP_290144.1 4537806 R 155864 CDS NP_290145.1 15804106 961051 complement(4538812..4539111) 1 NC_002655.2 No significant matches; hypothetical protein 4539111 961051 Z4985 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290145.1 4538812 R 155864 CDS NP_290146.1 15804107 961049 4539286..4540281 1 NC_002655.2 hypothetical protein 4540281 yiaH 961049 yiaH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290146.1 4539286 D 155864 CDS NP_290147.1 15804108 961048 complement(4540323..4540763) 1 NC_002655.2 hypothetical protein 4540763 yiaA 961048 yiaA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290147.1 4540323 R 155864 CDS NP_290148.1 15804109 961046 complement(4540806..4541159) 1 NC_002655.2 hypothetical protein 4541159 yiaB 961046 yiaB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290148.1 4540806 R 155864 CDS NP_290149.1 15804110 961045 complement(4541316..4542770) 1 NC_002655.2 xylulokinase 4542770 xylB 961045 xylB Escherichia coli O157:H7 str. EDL933 xylulokinase NP_290149.1 4541316 R 155864 CDS NP_290150.1 15804111 961044 complement(4542842..4544164) 1 NC_002655.2 catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase 4544164 xylA 961044 xylA Escherichia coli O157:H7 str. EDL933 xylose isomerase NP_290150.1 4542842 R 155864 CDS NP_290151.1 15804112 961043 4544530..4545522 1 NC_002655.2 periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity; D-xylose transporter subunit XylF 4545522 xylF 961043 xylF Escherichia coli O157:H7 str. EDL933 D-xylose transporter subunit XylF NP_290151.1 4544530 D 155864 CDS NP_290152.1 15804113 961042 4545600..4547141 1 NC_002655.2 with XylFH is part of the high affinity xylose ABC transporter; xylose transporter ATP-binding subunit 4547141 xylG 961042 xylG Escherichia coli O157:H7 str. EDL933 xylose transporter ATP-binding subunit NP_290152.1 4545600 D 155864 CDS NP_290153.1 15804114 961041 4547119..4548300 1 NC_002655.2 xylose transport, membrane component 4548300 xylH 961041 xylH Escherichia coli O157:H7 str. EDL933 xylose transport, membrane component NP_290153.1 4547119 D 155864 CDS NP_290154.1 15804115 961040 4548378..4549556 1 NC_002655.2 regulator of xyl operon 4549556 xylR 961040 xylR Escherichia coli O157:H7 str. EDL933 regulator of xyl operon NP_290154.1 4548378 D 155864 CDS NP_290155.1 15804116 961039 complement(4549664..4550488) 1 NC_002655.2 hypothetical protein 4550488 bax 961039 bax Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290155.1 4549664 R 155864 CDS NP_290156.1 15804117 961038 4550808..4552838 1 NC_002655.2 periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds; periplasmic alpha-amylase 4552838 malS 961038 malS Escherichia coli O157:H7 str. EDL933 periplasmic alpha-amylase NP_290156.1 4550808 D 155864 CDS NP_290157.1 15804118 961032 4553016..4554269 1 NC_002655.2 transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis; valine--pyruvate transaminase 4554269 avtA 961032 avtA Escherichia coli O157:H7 str. EDL933 valine--pyruvate transaminase NP_290157.1 4553016 D 155864 CDS NP_290158.1 15804119 961031 complement(4554421..4554894) 1 NC_002655.2 hypothetical protein 4554894 yiaI 961031 yiaI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290158.1 4554421 R 155864 CDS NP_290159.1 15804120 961029 4554445..4554789 1 NC_002655.2 No significant matches; hypothetical protein 4554789 961029 Z4999 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290159.1 4554445 D 155864 CDS NP_290160.1 15804121 961028 complement(4555138..4555953) 1 NC_002655.2 regulatory protein 4555953 961028 Z5000 Escherichia coli O157:H7 str. EDL933 regulatory protein NP_290160.1 4555138 R 155864 CDS NP_290161.1 15804122 960978 4556179..4557579 1 NC_002655.2 permease 4557579 960978 Z5001 Escherichia coli O157:H7 str. EDL933 permease NP_290161.1 4556179 D 155864 CDS NP_290162.1 15804123 960975 4557590..4559560 1 NC_002655.2 hypothetical protein 4559560 960975 Z5002 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290162.1 4557590 D 155864 CDS NP_290163.1 15804124 960972 complement(4559690..4560430) 1 NC_002655.2 hypothetical protein 4560430 yiaT 960972 yiaT Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290163.1 4559690 R 155864 CDS NP_290164.1 15804125 960970 4560554..4561528 1 NC_002655.2 LysR family transcriptional regulator 4561528 yiaU 960970 yiaU Escherichia coli O157:H7 str. EDL933 LysR family transcriptional regulator NP_290164.1 4560554 D 155864 CDS NP_290165.1 15804126 960968 complement(4561525..4562661) 1 NC_002655.2 hypothetical protein 4562661 yiaV 960968 yiaV Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290165.1 4561525 R 155864 CDS NP_290166.1 15804127 960967 complement(4562667..4562990) 1 NC_002655.2 hypothetical protein 4562990 yiaW 960967 yiaW Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290166.1 4562667 R 155864 CDS NP_290167.1 15804128 960966 complement(4563535..4565163) 1 NC_002655.2 lactaldehyde dehydrogenase 4565163 aldB 960966 aldB Escherichia coli O157:H7 str. EDL933 lactaldehyde dehydrogenase NP_290167.1 4563535 R 155864 CDS NP_290168.1 15804129 960965 complement(4565181..4566476) 1 NC_002655.2 hypothetical protein 4566476 960965 Z5009 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290168.1 4565181 R 155864 CDS NP_290169.1 15804130 960964 complement(4566606..4567757) 1 NC_002655.2 alcohol dehydrogenase 4567757 yiaY 960964 yiaY Escherichia coli O157:H7 str. EDL933 alcohol dehydrogenase NP_290169.1 4566606 R 155864 CDS NP_290170.1 15804131 960963 complement(4567946..4569790) 1 NC_002655.2 selenocysteinyl-tRNA-specific translation factor 4569790 selB 960963 selB Escherichia coli O157:H7 str. EDL933 selenocysteinyl-tRNA-specific translation factor NP_290170.1 4567946 R 155864 CDS NP_290171.1 15804132 960961 complement(4569787..4571178) 1 NC_002655.2 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase 4571178 selA 960961 selA Escherichia coli O157:H7 str. EDL933 selenocysteine synthase NP_290171.1 4569787 R 155864 CDS NP_290172.1 15804133 960960 complement(4571276..4571884) 1 NC_002655.2 glutathione S-transferase 4571884 yibF 960960 yibF Escherichia coli O157:H7 str. EDL933 glutathione S-transferase NP_290172.1 4571276 R 155864 CDS NP_290173.1 15804134 960959 4572113..4576246 1 NC_002655.2 rhsA protein in rhs element 4576246 rhsA 960959 rhsA Escherichia coli O157:H7 str. EDL933 rhsA protein in rhs element NP_290173.1 4572113 D 155864 CDS NP_290174.1 15804135 960958 4576267..4577109 1 NC_002655.2 hypothetical protein 4577109 yibA 960958 yibA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290174.1 4576267 D 155864 CDS NP_290175.1 15804136 960957 4577157..4578095 1 NC_002655.2 hypothetical protein 4578095 yibJ 960957 yibJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290175.1 4577157 D 155864 CDS NP_290176.1 15804137 960956 4578107..4578568 1 NC_002655.2 hypothetical protein 4578568 yibG 960956 yibG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290176.1 4578107 D 155864 CDS NP_290177.1 15804138 960955 complement(4580172..4581308) 1 NC_002655.2 hypothetical protein 4581308 yibH 960955 yibH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290177.1 4580172 R 155864 CDS NP_290178.1 15804139 960954 complement(4581311..4581673) 1 NC_002655.2 hypothetical protein 4581673 yibI 960954 yibI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290178.1 4581311 R 155864 CDS NP_290179.1 15804140 960953 4582210..4584123 1 NC_002655.2 PTS system mannitol-specific transporter subunit IIABC 4584123 mtlA 960953 mtlA Escherichia coli O157:H7 str. EDL933 PTS system mannitol-specific transporter subunit IIABC NP_290179.1 4582210 D 155864 CDS NP_290180.1 15804141 960952 4584218..4585366 1 NC_002655.2 mannitol-1-phosphate 5-dehydrogenase 4585366 mtlD 960952 mtlD Escherichia coli O157:H7 str. EDL933 mannitol-1-phosphate 5-dehydrogenase NP_290180.1 4584218 D 155864 CDS NP_290181.1 15804142 960951 4585366..4585953 1 NC_002655.2 Acts as a repressor of the mtlAD operon; mannitol repressor protein 4585953 mtlR 960951 mtlR Escherichia coli O157:H7 str. EDL933 mannitol repressor protein NP_290181.1 4585366 D 155864 CDS NP_290182.1 15804143 960950 4586459..4586821 1 NC_002655.2 hypothetical protein 4586821 yibL 960950 yibL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290182.1 4586459 D 155864 CDS NP_290183.1 15804144 960949 complement(4587135..4587293) 1 NC_002655.2 No significant matches; hypothetical protein 4587293 960949 Z5027 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290183.1 4587135 R 155864 CDS NP_290184.1 15804145 960948 4587466..4588047 1 NC_002655.2 No significant matches; hypothetical protein 4588047 960948 Z5028 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290184.1 4587466 D 155864 CDS NP_290185.1 15804146 960947 4588091..4592857 1 NC_002655.2 adhesin 4592857 960947 Z5029 Escherichia coli O157:H7 str. EDL933 adhesin NP_290185.1 4588091 D 155864 CDS NP_290186.1 15804147 960946 4593225..4594880 1 NC_002655.2 L-lactate permease 4594880 lldP 960946 lldP Escherichia coli O157:H7 str. EDL933 L-lactate permease NP_290186.1 4593225 D 155864 CDS NP_290187.1 15804148 960945 4594880..4595656 1 NC_002655.2 represses the lctPRD operon; DNA-binding transcriptional repressor LldR 4595656 lldR 960945 lldR Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional repressor LldR NP_290187.1 4594880 D 155864 CDS NP_290188.1 15804149 960943 4595653..4596843 1 NC_002655.2 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase 4596843 lldD 960943 lldD Escherichia coli O157:H7 str. EDL933 L-lactate dehydrogenase NP_290188.1 4595653 D 155864 CDS NP_290189.1 15804150 960941 4597029..4597502 1 NC_002655.2 member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates; tRNA/rRNA methyltransferase YibK 4597502 yibK 960941 yibK Escherichia coli O157:H7 str. EDL933 tRNA/rRNA methyltransferase YibK NP_290189.1 4597029 D 155864 CDS NP_290190.1 15804151 960940 complement(4597555..4598376) 1 NC_002655.2 catalyzes the O-acetylation of serine; serine acetyltransferase 4598376 cysE 960940 cysE Escherichia coli O157:H7 str. EDL933 serine acetyltransferase NP_290190.1 4597555 R 155864 CDS NP_290191.1 15804152 960939 complement(4598456..4599475) 1 NC_002655.2 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 4599475 gpsA 960939 gpsA Escherichia coli O157:H7 str. EDL933 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase NP_290191.1 4598456 R 155864 CDS NP_290192.1 15804153 960938 complement(4599475..4599942) 1 NC_002655.2 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 4599942 secB 960938 secB Escherichia coli O157:H7 str. EDL933 preprotein translocase subunit SecB NP_290192.1 4599475 R 155864 CDS NP_290193.1 15804154 960937 complement(4600005..4600256) 1 NC_002655.2 glutaredoxin 3 4600256 grxC 960937 grxC Escherichia coli O157:H7 str. EDL933 glutaredoxin 3 NP_290193.1 4600005 R 155864 CDS NP_290194.1 15804155 960936 complement(4600398..4600829) 1 NC_002655.2 hypothetical protein 4600829 yibN 960936 yibN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290194.1 4600398 R 155864 CDS NP_290195.1 15804156 960935 4601074..4602618 1 NC_002655.2 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 4602618 yibO 960935 yibO Escherichia coli O157:H7 str. EDL933 phosphoglyceromutase NP_290195.1 4601074 D 155864 CDS NP_290196.1 15804157 960933 4602628..4603911 1 NC_002655.2 hypothetical protein 4603911 yibP 960933 yibP Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290196.1 4602628 D 155864 CDS NP_290197.1 15804158 960932 4604041..4604874 1 NC_002655.2 hypothetical protein 4604874 yibQ 960932 yibQ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290197.1 4604041 D 155864 CDS NP_290198.1 15804159 960931 complement(4604880..4605896) 1 NC_002655.2 glycosyl transferase 4605896 yibD 960931 yibD Escherichia coli O157:H7 str. EDL933 glycosyl transferase NP_290198.1 4604880 R 155864 CDS NP_290199.1 15804160 960930 complement(4606135..4607160) 1 NC_002655.2 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase 4607160 tdh 960930 tdh Escherichia coli O157:H7 str. EDL933 L-threonine 3-dehydrogenase NP_290199.1 4606135 R 155864 CDS NP_290200.1 15804161 960928 complement(4607170..4608366) 1 NC_002655.2 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate CoA ligase 4608366 kbl 960928 kbl Escherichia coli O157:H7 str. EDL933 2-amino-3-ketobutyrate CoA ligase NP_290200.1 4607170 R 155864 CDS NP_290201.1 15804162 960927 complement(4608641..4609513) 1 NC_002655.2 hypothetical protein 4609513 htrL 960927 htrL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290201.1 4608641 R 155864 CDS NP_290202.1 15804163 960926 4609803..4610735 1 NC_002655.2 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-manno-heptose-6-epimerase 4610735 rfaD 960926 rfaD Escherichia coli O157:H7 str. EDL933 ADP-L-glycero-D-manno-heptose-6-epimerase NP_290202.1 4609803 D 155864 CDS NP_290203.1 15804164 960925 4610745..4611791 1 NC_002655.2 catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core; ADP-heptose--LPS heptosyltransferase 4611791 rfaF 960925 rfaF Escherichia coli O157:H7 str. EDL933 ADP-heptose--LPS heptosyltransferase NP_290203.1 4610745 D 155864 CDS NP_290204.1 15804165 960924 4611795..4612787 1 NC_002655.2 ADP-heptose--LPS heptosyltransferase 4612787 rfaC 960924 rfaC Escherichia coli O157:H7 str. EDL933 ADP-heptose--LPS heptosyltransferase NP_290204.1 4611795 D 155864 CDS NP_290205.1 15804166 960923 4612784..4613992 1 NC_002655.2 LPS biosynthesis rpteon 4613992 waaL 960923 waaL Escherichia coli O157:H7 str. EDL933 LPS biosynthesis rpteon NP_290205.1 4612784 D 155864 CDS NP_290206.1 15804167 960920 complement(4614028..4615170) 1 NC_002655.2 LPS biosynthesis rpteon 4615170 waaD 960920 waaD Escherichia coli O157:H7 str. EDL933 LPS biosynthesis rpteon NP_290206.1 4614028 R 155864 CDS NP_290207.1 15804168 960919 complement(4615179..4616192) 1 NC_002655.2 LPS biosynthesis rpteon 4616192 waaJ 960919 waaJ Escherichia coli O157:H7 str. EDL933 LPS biosynthesis rpteon NP_290207.1 4615179 R 155864 CDS NP_290208.1 15804169 960918 complement(4616217..4616924) 1 NC_002655.2 lipopolysaccharide core biosynthesis protein 4616924 waaY 960918 waaY Escherichia coli O157:H7 str. EDL933 lipopolysaccharide core biosynthesis protein NP_290208.1 4616217 R 155864 CDS NP_290209.1 15804170 960917 complement(4616950..4617957) 1 NC_002655.2 LPS biosynthesis rpteon 4617957 waaI 960917 waaI Escherichia coli O157:H7 str. EDL933 LPS biosynthesis rpteon NP_290209.1 4616950 R 155864 CDS NP_290210.1 15804171 960916 complement(4618000..4618806) 1 NC_002655.2 LPS biosynthesis rpteon 4618806 waaP 960916 waaP Escherichia coli O157:H7 str. EDL933 LPS biosynthesis rpteon NP_290210.1 4618000 R 155864 CDS NP_290211.1 15804172 960915 complement(4618790..4619914) 1 NC_002655.2 glucosyltransferase I; lipopolysaccharide core biosynthesis 4619914 rfaG 960915 rfaG Escherichia coli O157:H7 str. EDL933 glucosyltransferase I; lipopolysaccharide core biosynthesis NP_290211.1 4618790 R 155864 CDS NP_290212.1 15804173 960914 complement(4619911..4620969) 1 NC_002655.2 lipopolysaccharide core biosynthesis protein 4620969 waaQ 960914 waaQ Escherichia coli O157:H7 str. EDL933 lipopolysaccharide core biosynthesis protein NP_290212.1 4619911 R 155864 CDS NP_290213.1 15804174 960913 4621382..4622659 1 NC_002655.2 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 4622659 kdtA 960913 kdtA Escherichia coli O157:H7 str. EDL933 3-deoxy-D-manno-octulosonic-acid transferase NP_290213.1 4621382 D 155864 CDS NP_290214.1 15804175 960912 4622667..4623146 1 NC_002655.2 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 4623146 coaD 960912 coaD Escherichia coli O157:H7 str. EDL933 phosphopantetheine adenylyltransferase NP_290214.1 4622667 D 155864 CDS NP_290215.1 15804176 960911 complement(4623185..4623994) 1 NC_002655.2 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 4623994 mutM 960911 mutM Escherichia coli O157:H7 str. EDL933 formamidopyrimidine-DNA glycosylase NP_290215.1 4623185 R 155864 CDS NP_290216.1 15804177 960910 complement(4624092..4624259) 1 NC_002655.2 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 4624259 rpmG 960910 rpmG Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L33 NP_290216.1 4624092 R 155864 CDS NP_290217.1 15804178 960909 complement(4624280..4624516) 1 NC_002655.2 required for 70S ribosome assembly; 50S ribosomal protein L28 4624516 rpmB 960909 rpmB Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L28 NP_290217.1 4624280 R 155864 CDS NP_290218.1 15804179 960908 complement(4624733..4625407) 1 NC_002655.2 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 4625407 radC 960908 radC Escherichia coli O157:H7 str. EDL933 DNA repair protein RadC NP_290218.1 4624733 R 155864 CDS NP_290219.2 161367497 960907 4625573..4626793 1 NC_002655.2 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 4626793 dfp 960907 dfp Escherichia coli O157:H7 str. EDL933 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase NP_290219.2 4625573 D 155864 CDS NP_290220.1 15804181 960906 4626774..4627229 1 NC_002655.2 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 4627229 dut 960906 dut Escherichia coli O157:H7 str. EDL933 deoxyuridine 5'-triphosphate nucleotidohydrolase NP_290220.1 4626774 D 155864 CDS NP_290221.2 161367496 960905 4627336..4627932 1 NC_002655.2 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein 4627932 slmA 960905 slmA Escherichia coli O157:H7 str. EDL933 nucleoid occlusion protein NP_290221.2 4627336 D 155864 CDS NP_290222.1 15804183 960904 complement(4627969..4628610) 1 NC_002655.2 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 4628610 pyrE 960904 pyrE Escherichia coli O157:H7 str. EDL933 orotate phosphoribosyltransferase NP_290222.1 4627969 R 155864 CDS NP_290223.1 15804184 960903 complement(4628676..4629392) 1 NC_002655.2 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 4629392 rph 960903 rph Escherichia coli O157:H7 str. EDL933 ribonuclease PH NP_290223.1 4628676 R 155864 CDS NP_290224.1 15804185 960902 4629519..4630382 1 NC_002655.2 hypothetical protein 4630382 yicC 960902 yicC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290224.1 4629519 D 155864 CDS NP_290225.2 161367495 960901 4630603..4631427 1 NC_002655.2 DNA-damage-inducible protein D 4631427 dinD 960901 dinD Escherichia coli O157:H7 str. EDL933 DNA-damage-inducible protein D NP_290225.2 4630603 D 155864 CDS NP_290226.1 15804187 960900 4631665..4632336 1 NC_002655.2 hypothetical protein 4632336 yicG 960900 yicG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290226.1 4631665 D 155864 CDS NP_290227.2 161367494 960898 complement(4632333..4634015) 1 NC_002655.2 this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+; NAD-dependent DNA ligase LigB 4634015 ligB 960898 ligB Escherichia coli O157:H7 str. EDL933 NAD-dependent DNA ligase LigB NP_290227.2 4632333 R 155864 CDS NP_290228.1 15804189 960897 4634273..4634896 1 NC_002655.2 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 4634896 gmk 960897 gmk Escherichia coli O157:H7 str. EDL933 guanylate kinase NP_290228.1 4634273 D 155864 CDS NP_290229.1 15804190 960896 4634951..4635226 1 NC_002655.2 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 4635226 rpoZ 960896 rpoZ Escherichia coli O157:H7 str. EDL933 DNA-directed RNA polymerase subunit omega NP_290229.1 4634951 D 155864 CDS NP_290230.1 15804191 960895 4635245..4637353 1 NC_002655.2 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 4637353 spoT 960895 spoT Escherichia coli O157:H7 str. EDL933 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase NP_290230.1 4635245 D 155864 CDS NP_290231.1 15804192 960894 4637360..4638049 1 NC_002655.2 specifically modifies tRNA at position G18; tRNA guanosine-2'-O-methyltransferase 4638049 spoU 960894 spoU Escherichia coli O157:H7 str. EDL933 tRNA guanosine-2'-O-methyltransferase NP_290231.1 4637360 D 155864 CDS NP_290232.2 161367493 960893 4638055..4640136 1 NC_002655.2 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 4640136 recG 960893 recG Escherichia coli O157:H7 str. EDL933 ATP-dependent DNA helicase RecG NP_290232.2 4638055 D 155864 CDS NP_290233.1 15804194 960892 complement(4640121..4640987) 1 NC_002655.2 No significant matches; hypothetical protein 4640987 960892 Z5079 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290233.1 4640121 R 155864 CDS NP_290234.1 15804195 960891 complement(4640990..4642195) 1 NC_002655.2 glutamate transport 4642195 gltS 960891 gltS Escherichia coli O157:H7 str. EDL933 glutamate transport NP_290234.1 4640990 R 155864 CDS NP_290235.1 15804196 960890 4642475..4643866 1 NC_002655.2 transporter 4643866 yicE 960890 yicE Escherichia coli O157:H7 str. EDL933 transporter NP_290235.1 4642475 D 155864 CDS NP_290236.1 15804197 960889 4643987..4645696 1 NC_002655.2 hypothetical protein 4645696 yicH 960889 yicH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290236.1 4643987 D 155864 CDS NP_290237.1 15804198 960888 complement(4645749..4648067) 1 NC_002655.2 catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides; alpha-xylosidase 4648067 yicI 960888 yicI Escherichia coli O157:H7 str. EDL933 alpha-xylosidase NP_290237.1 4645749 R 155864 CDS NP_290238.2 161367492 960887 complement(4648077..4649459) 1 NC_002655.2 may be involved in the transport of galactosides-pentoses-hexuronides; transporter 4649459 yicJ 960887 yicJ Escherichia coli O157:H7 str. EDL933 transporter NP_290238.2 4648077 R 155864 CDS NP_290239.1 15804200 960885 4650042..4651223 1 NC_002655.2 integrase for prophage 933L and the LEE pathogenicity island 4651223 intL 960885 intL Escherichia coli O157:H7 str. EDL933 integrase for prophage 933L and the LEE pathogenicity island NP_290239.1 4650042 D 155864 CDS NP_290240.1 15804201 960883 4651322..4651672 1 NC_002655.2 hypothetical protein 4651672 960883 Z5088 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290240.1 4651322 D 155864 CDS NP_290241.1 15804202 960882 4651861..4652538 1 NC_002655.2 transposase 4652538 960882 Z5089 Escherichia coli O157:H7 str. EDL933 transposase NP_290241.1 4651861 D 155864 CDS NP_290242.1 15804203 960881 4652789..4653163 1 NC_002655.2 hypothetical protein 4653163 960881 Z5091 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290242.1 4652789 D 155864 CDS NP_290243.1 15804204 960880 4653160..4653651 1 NC_002655.2 hypothetical protein 4653651 960880 Z5092 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290243.1 4653160 D 155864 CDS NP_290244.1 15804205 960879 4653663..4653860 1 NC_002655.2 hypothetical protein 4653860 960879 Z5093 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290244.1 4653663 D 155864 CDS NP_290245.1 15804206 960878 4653945..4654286 1 NC_002655.2 hypothetical protein 4654286 960878 Z5094 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290245.1 4653945 D 155864 CDS NP_290246.1 15804207 960877 4654526..4654672 1 NC_002655.2 hypothetical protein 4654672 960877 Z5095 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290246.1 4654526 D 155864 CDS NP_290247.1 15804208 960876 4655042..4655443 1 NC_002655.2 prophage-associated protein 4655443 960876 Z5096 Escherichia coli O157:H7 str. EDL933 prophage-associated protein NP_290247.1 4655042 D 155864 CDS NP_290248.1 15804209 960874 4655440..4655787 1 NC_002655.2 prophage-associated protein 4655787 960874 Z5097 Escherichia coli O157:H7 str. EDL933 prophage-associated protein NP_290248.1 4655440 D 155864 CDS NP_290249.1 15804210 960873 4655837..4657375 1 NC_002655.2 prophage-associated protein 4657375 960873 Z5098 Escherichia coli O157:H7 str. EDL933 prophage-associated protein NP_290249.1 4655837 D 155864 CDS NP_290250.1 15804211 960871 complement(4658240..4658986) 1 NC_002655.2 hypothetical protein 4658986 espF 960871 espF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290250.1 4658240 R 155864 CDS NP_290251.1 15804212 960870 complement(4659071..4659349) 1 NC_002655.2 hypothetical protein 4659349 960870 Z5102 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290251.1 4659071 R 155864 CDS NP_290252.1 15804213 960869 complement(4659355..4659576) 1 NC_002655.2 hypothetical protein 4659576 escF 960869 escF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290252.1 4659355 R 155864 CDS NP_290253.1 15804214 960868 complement(4659612..4660019) 1 NC_002655.2 hypothetical protein 4660019 960868 Z5104 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290253.1 4659612 R 155864 CDS NP_290254.1 15804215 960867 complement(4660026..4660964) 1 NC_002655.2 hypothetical protein 4660964 espB 960867 espB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290254.1 4660026 R 155864 CDS NP_290255.1 15804216 960866 complement(4660985..4662109) 1 NC_002655.2 hypothetical protein 4662109 espD 960866 espD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290255.1 4660985 R 155864 CDS NP_290256.1 15804217 960865 complement(4662122..4662700) 1 NC_002655.2 hypothetical protein 4662700 espA 960865 espA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290256.1 4662122 R 155864 CDS NP_290257.1 15804218 960864 complement(4662759..4663814) 1 NC_002655.2 hypothetical protein 4663814 sepL 960864 sepL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290257.1 4662759 R 155864 CDS NP_290258.1 15804219 960863 4663957..4665177 1 NC_002655.2 hypothetical protein 4665177 escD 960863 escD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290258.1 4663957 D 155864 CDS NP_290259.1 15804220 960862 complement(4665441..4668245) 1 NC_002655.2 intimin adherence protein 4668245 eae 960862 eae Escherichia coli O157:H7 str. EDL933 intimin adherence protein NP_290259.1 4665441 R 155864 CDS NP_290260.1 15804221 960861 complement(4668305..4668775) 1 NC_002655.2 hypothetical protein 4668775 960861 Z5111 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290260.1 4668305 R 155864 CDS NP_290261.1 15804222 960860 complement(4668913..4670589) 1 NC_002655.2 translocated intimin receptor protein 4670589 tir 960860 tir Escherichia coli O157:H7 str. EDL933 translocated intimin receptor protein NP_290261.1 4668913 R 155864 CDS NP_290262.1 15804223 960859 complement(4671013..4671624) 1 NC_002655.2 hypothetical protein 4671624 960859 Z5113 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290262.1 4671013 R 155864 CDS NP_290263.1 15804224 960858 4671890..4672273 1 NC_002655.2 hypothetical protein 4672273 960858 Z5114 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290263.1 4671890 D 155864 CDS NP_290264.1 15804225 960857 complement(4672471..4672977) 1 NC_002655.2 hypothetical protein 4672977 960857 Z5115 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290264.1 4672471 R 155864 CDS NP_290265.1 15804226 960856 complement(4673008..4673925) 1 NC_002655.2 hypothetical protein 4673925 sepQ 960856 sepQ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290265.1 4673008 R 155864 CDS NP_290266.1 15804227 960855 complement(4673888..4674163) 1 NC_002655.2 hypothetical protein 4674163 960855 Z5117 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290266.1 4673888 R 155864 CDS NP_290267.1 15804228 960854 complement(4674297..4674674) 1 NC_002655.2 hypothetical protein 4674674 960854 Z5118 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290267.1 4674297 R 155864 CDS NP_290268.1 15804229 960853 complement(4674677..4676017) 1 NC_002655.2 hypothetical protein 4676017 escN 960853 escN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290268.1 4674677 R 155864 CDS NP_290269.1 15804230 960852 complement(4676001..4678028) 1 NC_002655.2 hypothetical protein 4678028 escV 960852 escV Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290269.1 4676001 R 155864 CDS NP_290270.1 15804231 960851 complement(4678025..4678378) 1 NC_002655.2 hypothetical protein 4678378 960851 Z5121 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290270.1 4678025 R 155864 CDS NP_290271.1 15804232 960850 4678563..4678862 1 NC_002655.2 hypothetical protein 4678862 sepZ 960850 sepZ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290271.1 4678563 D 155864 CDS NP_290272.1 15804233 960849 4678895..4679323 1 NC_002655.2 hypothetical protein 4679323 960849 Z5123 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290272.1 4678895 D 155864 CDS NP_290273.1 15804234 960848 4679326..4679898 1 NC_002655.2 hypothetical protein 4679898 escJ 960848 escJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290273.1 4679326 D 155864 CDS NP_290274.1 15804235 960847 4679904..4680359 1 NC_002655.2 hypothetical protein 4680359 960847 Z5125 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290274.1 4679904 D 155864 CDS NP_290275.1 15804236 960846 4680359..4681897 1 NC_002655.2 hypothetical protein 4681897 escC 960846 escC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290275.1 4680359 D 155864 CDS NP_290276.1 15804237 960845 4681911..4682366 1 NC_002655.2 hypothetical protein 4682366 cesD 960845 cesD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290276.1 4681911 D 155864 CDS NP_290277.1 15804238 960843 complement(4682750..4683163) 1 NC_002655.2 hypothetical protein 4683163 960843 Z5128 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290277.1 4682750 R 155864 CDS NP_290278.1 15804239 960842 complement(4683218..4683589) 1 NC_002655.2 negative regulator GrlR 4683589 960842 Z5129 Escherichia coli O157:H7 str. EDL933 negative regulator GrlR NP_290278.1 4683218 R 155864 CDS NP_290279.1 15804240 960841 4683785..4684243 1 NC_002655.2 hypothetical protein 4684243 960841 Z5131 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290279.1 4683785 D 155864 CDS NP_290280.1 15804241 960840 complement(4684240..4685277) 1 NC_002655.2 member of a type III secretion system which is part of a pathogenicity island in Salmonella, Yersinia and pathogenic Escherichia coli; secretion system apparatus protein SsaU 4685277 escU 960840 escU Escherichia coli O157:H7 str. EDL933 secretion system apparatus protein SsaU NP_290280.1 4684240 R 155864 CDS NP_290281.1 15804242 960839 complement(4685270..4686046) 1 NC_002655.2 hypothetical protein 4686046 escT 960839 escT Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290281.1 4685270 R 155864 CDS NP_290282.1 15804243 960838 complement(4686046..4686315) 1 NC_002655.2 hypothetical protein 4686315 escS 960838 escS Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290282.1 4686046 R 155864 CDS NP_290283.1 15804244 960837 complement(4686315..4686968) 1 NC_002655.2 part of a set of proteins involved in the infection of eukaryotic cells; in plant pathogens involved in the hypersensitivity response; type III secretion system protein 4686968 escR 960837 escR Escherichia coli O157:H7 str. EDL933 type III secretion system protein NP_290283.1 4686315 R 155864 CDS NP_290284.1 15804245 960836 complement(4686973..4687587) 1 NC_002655.2 hypothetical protein 4687587 960836 Z5136 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290284.1 4686973 R 155864 CDS NP_290285.1 15804246 960835 complement(4687613..4688212) 1 NC_002655.2 hypothetical protein 4688212 960835 Z5137 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290285.1 4687613 R 155864 CDS NP_290286.1 15804247 960834 complement(4688209..4688532) 1 NC_002655.2 hypothetical protein 4688532 960834 Z5138 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290286.1 4688209 R 155864 CDS NP_290287.1 15804248 960833 complement(4688536..4688754) 1 NC_002655.2 hypothetical protein 4688754 960833 Z5139 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290287.1 4688536 R 155864 CDS NP_290288.1 15804249 960828 complement(4688769..4689158) 1 NC_002655.2 hypothetical protein 4689158 960828 Z5140 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290288.1 4688769 R 155864 CDS NP_290289.1 15804250 960827 4690403..4691599 1 NC_002655.2 hypothetical protein 4691599 960827 Z5142 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290289.1 4690403 D 155864 CDS NP_290290.1 15804251 960826 4691727..4692545 1 NC_002655.2 hypothetical protein 4692545 960826 Z5143 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290290.1 4691727 D 155864 CDS NP_290291.1 15804252 960823 4693565..4694488 1 NC_002655.2 permease transporter 4694488 yicL 960823 yicL Escherichia coli O157:H7 str. EDL933 permease transporter NP_290291.1 4693565 D 155864 CDS NP_290292.1 15804253 960822 complement(4694492..4695310) 1 NC_002655.2 hypothetical protein 4695310 nlpA 960822 nlpA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290292.1 4694492 R 155864 CDS NP_290293.1 15804254 960821 4695463..4695825 1 NC_002655.2 No significant matches; hypothetical protein 4695825 960821 Z5148 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290293.1 4695463 D 155864 CDS NP_290294.2 161367491 960820 complement(4695866..4697056) 1 NC_002655.2 experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS; ribonucleoside transporter 4697056 nepI 960820 nepI Escherichia coli O157:H7 str. EDL933 ribonucleoside transporter NP_290294.2 4695866 R 155864 CDS NP_290295.1 15804256 960817 4697290..4697643 1 NC_002655.2 hypothetical protein 4697643 960817 Z5150 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290295.1 4697290 D 155864 CDS NP_290296.1 15804257 960816 4697627..4697950 1 NC_002655.2 hypothetical protein 4697950 960816 Z5151 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290296.1 4697627 D 155864 CDS NP_290297.1 15804258 960815 complement(4698066..4698545) 1 NC_002655.2 hypothetical protein 4698545 yicN 960815 yicN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290297.1 4698066 R 155864 CDS NP_290298.1 15804259 960814 complement(4698571..4698900) 1 NC_002655.2 hypothetical protein 4698900 960814 Z5153 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290298.1 4698571 R 155864 CDS NP_290299.1 15804260 960813 complement(4698909..4699982) 1 NC_002655.2 hypothetical protein 4699982 960813 Z5154 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290299.1 4698909 R 155864 CDS NP_290300.1 15804261 960811 4700079..4701845 1 NC_002655.2 catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type; cryptic adenine deaminase 4701845 yicP 960811 yicP Escherichia coli O157:H7 str. EDL933 cryptic adenine deaminase NP_290300.1 4700079 D 155864 CDS NP_290301.1 15804262 960810 complement(4701891..4703282) 1 NC_002655.2 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate; sugar phosphate antiporter 4703282 uhpT 960810 uhpT Escherichia coli O157:H7 str. EDL933 sugar phosphate antiporter NP_290301.1 4701891 R 155864 CDS NP_290302.1 15804263 960809 complement(4703420..4704742) 1 NC_002655.2 membrane protein regulates uhpT expression; regulatory protein UhpC 4704742 uhpC 960809 uhpC Escherichia coli O157:H7 str. EDL933 regulatory protein UhpC NP_290302.1 4703420 R 155864 CDS NP_290303.1 15804264 960807 complement(4704749..4706254) 1 NC_002655.2 Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph; sensory histidine kinase UhpB 4706254 uhpB 960807 uhpB Escherichia coli O157:H7 str. EDL933 sensory histidine kinase UhpB NP_290303.1 4704749 R 155864 CDS NP_290304.1 15804265 960804 complement(4706251..4706841) 1 NC_002655.2 response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter; DNA-binding transcriptional activator UhpA 4706841 uhpA 960804 uhpA Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional activator UhpA NP_290304.1 4706251 R 155864 CDS NP_290305.1 15804266 960802 complement(4707003..4708106) 1 NC_002655.2 No significant matches; hypothetical protein 4708106 960802 Z5160 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290305.1 4707003 R 155864 CDS NP_290306.1 15804267 960801 complement(4708122..4708499) 1 NC_002655.2 No significant matches; hypothetical protein 4708499 960801 Z5161 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290306.1 4708122 R 155864 CDS NP_290307.1 15804268 960800 complement(4708714..4709196) 1 NC_002655.2 No significant matches; hypothetical protein 4709196 960800 Z5162 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290307.1 4708714 R 155864 CDS NP_290308.1 15804269 960799 complement(4709344..4710009) 1 NC_002655.2 No significant matches; hypothetical protein 4710009 960799 Z5163 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290308.1 4709344 R 155864 CDS NP_290309.1 15804270 960798 complement(4710260..4710550) 1 NC_002655.2 with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit; acetolactate synthase 1 regulatory subunit 4710550 ilvN 960798 ilvN Escherichia coli O157:H7 str. EDL933 acetolactate synthase 1 regulatory subunit NP_290309.1 4710260 R 155864 CDS NP_290310.1 15804271 960797 complement(4710554..4712242) 1 NC_002655.2 catalyzes the formation of 2-acetolactate from pyruvate; acetolactate synthase catalytic subunit 4712242 ilvB 960797 ilvB Escherichia coli O157:H7 str. EDL933 acetolactate synthase catalytic subunit NP_290310.1 4710554 R 155864 CDS NP_290311.1 15804272 960796 complement(4712348..4712446) 1 NC_002655.2 ilvB operon leader peptide 4712446 ivbL 960796 ivbL Escherichia coli O157:H7 str. EDL933 ilvB operon leader peptide NP_290311.1 4712348 R 155864 CDS NP_290312.1 15804273 960794 4713374..4714564 1 NC_002655.2 multidrug efflux protein involved in adaptation to low energy shock; multidrug resistance protein D 4714564 emrD 960794 emrD Escherichia coli O157:H7 str. EDL933 multidrug resistance protein D NP_290312.1 4713374 D 155864 CDS NP_290313.1 15804274 960793 complement(4714572..4715069) 1 NC_002655.2 transcriptional regulator 4715069 yidF 960793 yidF Escherichia coli O157:H7 str. EDL933 transcriptional regulator NP_290313.1 4714572 R 155864 CDS NP_290314.1 15804275 960789 complement(4715066..4715428) 1 NC_002655.2 hypothetical protein 4715428 yidG 960789 yidG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290314.1 4715066 R 155864 CDS NP_290315.1 15804276 960785 complement(4715418..4715765) 1 NC_002655.2 hypothetical protein 4715765 yidH 960785 yidH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290315.1 4715418 R 155864 CDS NP_290316.1 15804277 960784 4715874..4716323 1 NC_002655.2 hypothetical protein 4716323 yidI 960784 yidI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290316.1 4715874 D 155864 CDS NP_290317.1 15804278 960781 complement(4716370..4717863) 1 NC_002655.2 sulfatase 4717863 yidJ 960781 yidJ Escherichia coli O157:H7 str. EDL933 sulfatase NP_290317.1 4716370 R 155864 CDS NP_290318.1 15804279 960779 complement(4717860..4719575) 1 NC_002655.2 uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function; symporter YidK 4719575 yidK 960779 yidK Escherichia coli O157:H7 str. EDL933 symporter YidK NP_290318.1 4717860 R 155864 CDS NP_290319.1 15804280 960778 4719712..4720635 1 NC_002655.2 AraC family transcriptional regulator 4720635 yidL 960778 yidL Escherichia coli O157:H7 str. EDL933 AraC family transcriptional regulator NP_290319.1 4719712 D 155864 CDS NP_290320.1 15804281 960777 complement(4720632..4721954) 1 NC_002655.2 6-phospho-beta-glucosidase 4721954 960777 Z5177 Escherichia coli O157:H7 str. EDL933 6-phospho-beta-glucosidase NP_290320.1 4720632 R 155864 CDS NP_290321.1 15804282 960773 complement(4721954..4723576) 1 NC_002655.2 PTS component 4723576 960773 Z5178 Escherichia coli O157:H7 str. EDL933 PTS component NP_290321.1 4721954 R 155864 CDS NP_290322.1 15804283 960772 4723866..4724582 1 NC_002655.2 transcriptional regulator 4724582 yidP 960772 yidP Escherichia coli O157:H7 str. EDL933 transcriptional regulator NP_290322.1 4723866 D 155864 CDS NP_290323.2 161367490 960771 complement(4724579..4726240) 1 NC_002655.2 hypothetical protein 4726240 yidE 960771 yidE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290323.2 4724579 R 155864 CDS NP_290324.2 161367489 960767 complement(4726436..4726864) 1 NC_002655.2 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent; heat shock chaperone IbpB 4726864 ibpB 960767 ibpB Escherichia coli O157:H7 str. EDL933 heat shock chaperone IbpB NP_290324.2 4726436 R 155864 CDS NP_290325.1 15804286 960764 complement(4726976..4727389) 1 NC_002655.2 with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; heat shock protein IbpA 4727389 ibpA 960764 ibpA Escherichia coli O157:H7 str. EDL933 heat shock protein IbpA NP_290325.1 4726976 R 155864 CDS NP_290326.2 161367488 960763 4727695..4728027 1 NC_002655.2 hypothetical protein 4728027 yidQ 960763 yidQ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290326.2 4727695 D 155864 CDS NP_290327.1 15804288 960762 complement(4728029..4729279) 1 NC_002655.2 hypothetical protein 4729279 yidR 960762 yidR Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290327.1 4728029 R 155864 CDS NP_290328.2 161367487 960761 4729344..4730408 1 NC_002655.2 FAD/NAD(P)-binding domain; oxidoreductase 4730408 yidS 960761 yidS Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_290328.2 4729344 D 155864 CDS NP_290329.2 161367486 960760 4730654..4731310 1 NC_002655.2 hypothetical protein 4731310 960760 Z5187 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290329.2 4730654 D 155864 CDS NP_290330.1 15804291 960759 complement(4731356..4732168) 1 NC_002655.2 YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins; sugar phosphatase 4732168 yidA 960759 yidA Escherichia coli O157:H7 str. EDL933 sugar phosphatase NP_290330.1 4731356 R 155864 CDS NP_290331.1 15804292 960758 complement(4732283..4732690) 1 NC_002655.2 hypothetical protein 4732690 yidB 960758 yidB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290331.1 4732283 R 155864 CDS NP_290332.1 15804293 960757 complement(4732921..4735335) 1 NC_002655.2 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 4735335 gyrB 960757 gyrB Escherichia coli O157:H7 str. EDL933 DNA gyrase subunit B NP_290332.1 4732921 R 155864 CDS NP_290333.1 15804294 960756 complement(4735364..4736437) 1 NC_002655.2 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 4736437 recF 960756 recF Escherichia coli O157:H7 str. EDL933 recombination protein F NP_290333.1 4735364 R 155864 CDS NP_290334.1 15804295 960755 complement(4736437..4737537) 1 NC_002655.2 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 4737537 dnaN 960755 dnaN Escherichia coli O157:H7 str. EDL933 DNA polymerase III subunit beta NP_290334.1 4736437 R 155864 CDS NP_290335.1 15804296 960754 complement(4737542..4738945) 1 NC_002655.2 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosome replication initiator DnaA 4738945 dnaA 960754 dnaA Escherichia coli O157:H7 str. EDL933 chromosome replication initiator DnaA NP_290335.1 4737542 R 155864 CDS NP_290336.1 15804297 960753 4739552..4739692 1 NC_002655.2 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 4739692 rpmH 960753 rpmH Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L34 NP_290336.1 4739552 D 155864 CDS NP_290337.1 15804298 960752 4739709..4740068 1 NC_002655.2 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 4740068 rnpA 960752 rnpA Escherichia coli O157:H7 str. EDL933 ribonuclease P NP_290337.1 4739709 D 155864 CDS NP_290338.1 15804299 960751 4740292..4741938 1 NC_002655.2 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 4741938 yidC 960751 yidC Escherichia coli O157:H7 str. EDL933 inner membrane protein translocase component YidC NP_290338.1 4740292 D 155864 CDS NP_290339.1 15804300 960750 4742044..4743408 1 NC_002655.2 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 4743408 trmE 960750 trmE Escherichia coli O157:H7 str. EDL933 tRNA modification GTPase TrmE NP_290339.1 4742044 D 155864 CDS NP_290340.1 15804301 960749 complement(4743556..4743777) 1 NC_002655.2 No significant matches; hypothetical protein 4743777 960749 Z5199 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290340.1 4743556 R 155864 CDS NP_290341.1 15804302 960748 complement(4743737..4745725) 1 NC_002655.2 hypothetical protein 4745725 960748 Z5200 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290341.1 4743737 R 155864 CDS NP_290342.1 15804303 960747 complement(4745830..4745934) 1 NC_002655.2 No significant matches; hypothetical protein 4745934 960747 Z5201 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290342.1 4745830 R 155864 CDS NP_290343.1 15804304 960746 4746125..4746199 1 NC_002655.2 tryptophanase 4746199 tnaL 960746 tnaL Escherichia coli O157:H7 str. EDL933 tryptophanase NP_290343.1 4746125 D 155864 CDS NP_290344.1 15804305 960743 4746405..4747835 1 NC_002655.2 tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan; tryptophanase 4747835 tnaA 960743 tnaA Escherichia coli O157:H7 str. EDL933 tryptophanase NP_290344.1 4746405 D 155864 CDS NP_290345.1 15804306 960741 4747926..4749173 1 NC_002655.2 tryptophan transporter of low affinity; tryptophan permease 4749173 tnaB 960741 tnaB Escherichia coli O157:H7 str. EDL933 tryptophan permease NP_290345.1 4747926 D 155864 CDS NP_290346.1 15804307 960740 4749305..4750480 1 NC_002655.2 Confers resistance to chloramphenicol; multidrug efflux system protein MdtL 4750480 yidY 960740 yidY Escherichia coli O157:H7 str. EDL933 multidrug efflux system protein MdtL NP_290346.1 4749305 D 155864 CDS NP_290347.1 15804308 960738 4750455..4751414 1 NC_002655.2 Involved in anaerobic NO protection; DNA-binding transcriptional regulator YidZ 4751414 yidZ 960738 yidZ Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator YidZ NP_290347.1 4750455 D 155864 CDS NP_290348.1 15804309 960737 4751559..4752320 1 NC_002655.2 hypothetical protein 4752320 yieE 960737 yieE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290348.1 4751559 D 155864 CDS NP_290349.1 15804310 960732 4752342..4752908 1 NC_002655.2 hypothetical protein 4752908 yieF 960732 yieF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290349.1 4752342 D 155864 CDS NP_290350.1 15804311 960729 complement(4752962..4754299) 1 NC_002655.2 membrane / transport protein 4754299 yieG 960729 yieG Escherichia coli O157:H7 str. EDL933 membrane / transport protein NP_290350.1 4752962 R 155864 CDS NP_290351.1 15804312 960728 4754465..4755130 1 NC_002655.2 YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily; 6-phosphogluconate phosphatase 4755130 yieH 960728 yieH Escherichia coli O157:H7 str. EDL933 6-phosphogluconate phosphatase NP_290351.1 4754465 D 155864 CDS NP_290352.1 15804313 960727 complement(4755267..4757675) 1 NC_002655.2 hypothetical protein 4757675 960727 Z5211 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290352.1 4755267 R 155864 CDS NP_290353.1 15804314 960725 4757976..4758647 1 NC_002655.2 No significant matches; hypothetical protein 4758647 960725 Z5212 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290353.1 4757976 D 155864 CDS NP_290354.1 15804315 960723 4758738..4759163 1 NC_002655.2 No significant matches; hypothetical protein 4759163 960723 Z5213 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290354.1 4758738 D 155864 CDS NP_290355.1 15804316 960719 complement(4759632..4762016) 1 NC_002655.2 hypothetical protein 4762016 960719 Z5214 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290355.1 4759632 R 155864 CDS NP_290356.1 15804317 960717 complement(4762542..4763267) 1 NC_002655.2 regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon; transcriptional regulator PhoU 4763267 phoU 960717 phoU Escherichia coli O157:H7 str. EDL933 transcriptional regulator PhoU NP_290356.1 4762542 R 155864 CDS NP_290357.1 15804318 960716 complement(4763282..4764055) 1 NC_002655.2 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 4764055 pstB 960716 pstB Escherichia coli O157:H7 str. EDL933 phosphate transporter ATP-binding protein NP_290357.1 4763282 R 155864 CDS NP_290358.1 15804319 960711 complement(4764238..4765128) 1 NC_002655.2 Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PtsA 4765128 pstA 960711 pstA Escherichia coli O157:H7 str. EDL933 phosphate transporter permease subunit PtsA NP_290358.1 4764238 R 155864 CDS NP_290359.1 15804320 960700 complement(4765128..4766087) 1 NC_002655.2 part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PstC 4766087 pstC 960700 pstC Escherichia coli O157:H7 str. EDL933 phosphate transporter permease subunit PstC NP_290359.1 4765128 R 155864 CDS NP_290360.1 15804321 960698 complement(4766174..4767214) 1 NC_002655.2 phosphate ABC transporter substrate-binding protein 4767214 pstS 960698 pstS Escherichia coli O157:H7 str. EDL933 phosphate ABC transporter substrate-binding protein NP_290360.1 4766174 R 155864 CDS NP_290361.1 15804322 960697 complement(4767426..4768508) 1 NC_002655.2 fimbrial protein 4768508 960697 Z5220 Escherichia coli O157:H7 str. EDL933 fimbrial protein NP_290361.1 4767426 R 155864 CDS NP_290362.1 15804323 960696 complement(4768536..4769606) 1 NC_002655.2 fimbrial protein 4769606 960696 Z5221 Escherichia coli O157:H7 str. EDL933 fimbrial protein NP_290362.1 4768536 R 155864 CDS NP_290363.1 15804324 960695 complement(4769618..4772152) 1 NC_002655.2 fimbrial usher 4772152 960695 Z5222 Escherichia coli O157:H7 str. EDL933 fimbrial usher NP_290363.1 4769618 R 155864 CDS NP_290364.1 15804325 960693 complement(4772174..4772335) 1 NC_002655.2 No significant matches; fimbrial chaperone 4772335 960693 Z5223 Escherichia coli O157:H7 str. EDL933 fimbrial chaperone NP_290364.1 4772174 R 155864 CDS NP_290365.1 15804326 960691 complement(4772476..4772859) 1 NC_002655.2 fimbrial chaperone 4772859 960691 Z5224 Escherichia coli O157:H7 str. EDL933 fimbrial chaperone NP_290365.1 4772476 R 155864 CDS NP_290366.1 15804327 960681 complement(4772963..4773565) 1 NC_002655.2 major fimbrial subunit 4773565 960681 Z5225 Escherichia coli O157:H7 str. EDL933 major fimbrial subunit NP_290366.1 4772963 R 155864 CDS NP_290368.1 15804329 960579 complement(4774265..4776094) 1 NC_002655.2 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 4776094 glmS 960579 glmS Escherichia coli O157:H7 str. EDL933 glucosamine--fructose-6-phosphate aminotransferase NP_290368.1 4774265 R 155864 CDS NP_290369.1 15804330 960502 complement(4776256..4777626) 1 NC_002655.2 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 4777626 glmU 960502 glmU Escherichia coli O157:H7 str. EDL933 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase NP_290369.1 4776256 R 155864 CDS NP_290370.1 15804331 960452 complement(4777978..4778397) 1 NC_002655.2 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon 4778397 atpC 960452 atpC Escherichia coli O157:H7 str. EDL933 ATP synthase F0F1 subunit epsilon NP_290370.1 4777978 R 155864 CDS NP_290371.1 15804332 960448 complement(4778418..4779800) 1 NC_002655.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta 4779800 atpD 960448 atpD Escherichia coli O157:H7 str. EDL933 ATP synthase F0F1 subunit beta NP_290371.1 4778418 R 155864 CDS NP_290372.1 15804333 960442 complement(4779827..4780690) 1 NC_002655.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma 4780690 atpG 960442 atpG Escherichia coli O157:H7 str. EDL933 ATP synthase F0F1 subunit gamma NP_290372.1 4779827 R 155864 CDS NP_290373.1 15804334 960441 complement(4780741..4782282) 1 NC_002655.2 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha 4782282 atpA 960441 atpA Escherichia coli O157:H7 str. EDL933 ATP synthase F0F1 subunit alpha NP_290373.1 4780741 R 155864 CDS NP_290374.1 15804335 960439 complement(4782295..4782828) 1 NC_002655.2 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta 4782828 atpH 960439 atpH Escherichia coli O157:H7 str. EDL933 ATP synthase F0F1 subunit delta NP_290374.1 4782295 R 155864 CDS NP_290375.1 15804336 960438 complement(4782843..4783313) 1 NC_002655.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B 4783313 atpF 960438 atpF Escherichia coli O157:H7 str. EDL933 ATP synthase F0F1 subunit B NP_290375.1 4782843 R 155864 CDS NP_290376.1 15804337 960436 complement(4783375..4783614) 1 NC_002655.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C 4783614 atpE 960436 atpE Escherichia coli O157:H7 str. EDL933 ATP synthase F0F1 subunit C NP_290376.1 4783375 R 155864 CDS NP_290377.1 15804338 960435 complement(4783661..4784476) 1 NC_002655.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A 4784476 atpB 960435 atpB Escherichia coli O157:H7 str. EDL933 ATP synthase F0F1 subunit A NP_290377.1 4783661 R 155864 CDS NP_290378.2 161367485 960433 complement(4784485..4784865) 1 NC_002655.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I 4784865 atpI 960433 atpI Escherichia coli O157:H7 str. EDL933 F0F1 ATP synthase subunit I NP_290378.2 4784485 R 155864 CDS NP_290379.1 15804340 960431 complement(4785482..4786105) 1 NC_002655.2 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 4786105 gidB 960431 gidB Escherichia coli O157:H7 str. EDL933 16S rRNA methyltransferase GidB NP_290379.1 4785482 R 155864 CDS NP_290380.1 15804341 960429 complement(4786169..4788058) 1 NC_002655.2 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 4788058 gidA 960429 gidA Escherichia coli O157:H7 str. EDL933 tRNA uridine 5-carboxymethylaminomethyl modification protein GidA NP_290380.1 4786169 R 155864 CDS NP_290381.1 15804342 960425 complement(4788437..4788880) 1 NC_002655.2 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 4788880 mioC 960425 mioC Escherichia coli O157:H7 str. EDL933 flavodoxin NP_290381.1 4788437 R 155864 CDS NP_290382.1 15804343 960424 complement(4788970..4789428) 1 NC_002655.2 transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC 4789428 asnC 960424 asnC Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator AsnC NP_290382.1 4788970 R 155864 CDS NP_290383.1 15804344 960423 4789580..4790572 1 NC_002655.2 catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 4790572 asnA 960423 asnA Escherichia coli O157:H7 str. EDL933 asparagine synthetase AsnA NP_290383.1 4789580 D 155864 CDS NP_290384.2 161367484 960421 complement(4790577..4792028) 1 NC_002655.2 contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA; hypothetical protein 4792028 yieM 960421 yieM Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290384.2 4790577 R 155864 CDS NP_290385.2 228979042 960420 complement(4792022..4793518) 1 NC_002655.2 interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase; regulatory ATPase RavA 4793518 yieN 960420 yieN Escherichia coli O157:H7 str. EDL933 regulatory ATPase RavA NP_290385.2 4792022 R 155864 CDS NP_290386.1 15804347 960419 4793741..4795609 1 NC_002655.2 Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH; potassium transport protein Kup 4795609 trkD 960419 trkD Escherichia coli O157:H7 str. EDL933 potassium transport protein Kup NP_290386.1 4793741 D 155864 CDS NP_290387.2 228979041 960418 4795776..4796195 1 NC_002655.2 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 4796195 rbsD 960418 rbsD Escherichia coli O157:H7 str. EDL933 D-ribose pyranase NP_290387.2 4795776 D 155864 CDS NP_290388.1 15804349 960417 4796203..4797708 1 NC_002655.2 with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain; D-ribose transporter ATP-binding protein 4797708 rbsA 960417 rbsA Escherichia coli O157:H7 str. EDL933 D-ribose transporter ATP-binding protein NP_290388.1 4796203 D 155864 CDS NP_290389.1 15804350 960416 4797713..4798678 1 NC_002655.2 functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease 4798678 rbsC 960416 rbsC Escherichia coli O157:H7 str. EDL933 ribose ABC transporter permease NP_290389.1 4797713 D 155864 CDS NP_290390.1 15804351 960415 4798703..4799593 1 NC_002655.2 periplasmic substrate-binding component of the ATP-dependent ribose transport system; D-ribose transporter subunit RbsB 4799593 rbsB 960415 rbsB Escherichia coli O157:H7 str. EDL933 D-ribose transporter subunit RbsB NP_290390.1 4798703 D 155864 CDS NP_290391.1 15804352 960414 4799719..4800648 1 NC_002655.2 catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase 4800648 rbsK 960414 rbsK Escherichia coli O157:H7 str. EDL933 ribokinase NP_290391.1 4799719 D 155864 CDS NP_290392.1 15804353 960413 4800652..4801644 1 NC_002655.2 DNA-binding transcriptional repressor of ribose metabolism; transcriptional repressor RbsR 4801644 rbsR 960413 rbsR Escherichia coli O157:H7 str. EDL933 transcriptional repressor RbsR NP_290392.1 4800652 D 155864 CDS NP_290393.1 15804354 960412 complement(4801610..4803037) 1 NC_002655.2 transporter 4803037 yieO 960412 yieO Escherichia coli O157:H7 str. EDL933 transporter NP_290393.1 4801610 R 155864 CDS NP_290394.1 15804355 960411 complement(4803060..4803752) 1 NC_002655.2 hypothetical protein 4803752 yieP 960411 yieP Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290394.1 4803060 R 155864 CDS NP_290395.1 15804992 959624 complement(4809553..4810392) 1 NC_002655.2 Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon; transcriptional regulator HdfR 4810392 yifA 959624 yifA Escherichia coli O157:H7 str. EDL933 transcriptional regulator HdfR NP_290395.1 4809553 R 155864 CDS NP_290396.1 15804356 960404 4810511..4810849 1 NC_002655.2 hypothetical protein 4810849 yifE 960404 yifE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290396.1 4810511 D 155864 CDS NP_290397.1 15804357 960403 complement(4810874..4812424) 1 NC_002655.2 among the AAA+ ATPases, the YifB protease belongs to the Helix 2 insert clade; unknown function; ATP-dependent protease 4812424 yifB 960403 yifB Escherichia coli O157:H7 str. EDL933 ATP-dependent protease NP_290397.1 4810874 R 155864 CDS NP_290398.1 15804358 960402 4812747..4812845 1 NC_002655.2 ilvG operon leader peptide 4812845 ilvL 960402 ilvL Escherichia coli O157:H7 str. EDL933 ilvG operon leader peptide NP_290398.1 4812747 D 155864 CDS NP_290399.1 15804359 960401 4812985..4814631 1 NC_002655.2 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase 2 catalytic subunit 4814631 ilvG 960401 ilvG Escherichia coli O157:H7 str. EDL933 acetolactate synthase 2 catalytic subunit NP_290399.1 4812985 D 155864 CDS NP_290400.1 15804360 960400 4814628..4814891 1 NC_002655.2 acetolactate synthase 2 regulatory subunit 4814891 ilvM 960400 ilvM Escherichia coli O157:H7 str. EDL933 acetolactate synthase 2 regulatory subunit NP_290400.1 4814628 D 155864 CDS NP_290401.1 15804361 960399 4814911..4815840 1 NC_002655.2 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 4815840 ilvE 960399 ilvE Escherichia coli O157:H7 str. EDL933 branched-chain amino acid aminotransferase NP_290401.1 4814911 D 155864 CDS NP_290402.1 15804362 960398 4815906..4817756 1 NC_002655.2 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 4817756 ilvD 960398 ilvD Escherichia coli O157:H7 str. EDL933 dihydroxy-acid dehydratase NP_290402.1 4815906 D 155864 CDS NP_290403.1 15804363 960397 4817759..4819306 1 NC_002655.2 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase 4819306 ilvA 960397 ilvA Escherichia coli O157:H7 str. EDL933 threonine dehydratase NP_290403.1 4817759 D 155864 CDS NP_290404.1 15804364 960396 complement(4819358..4820251) 1 NC_002655.2 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; IlvY family transcriptional regulator 4820251 ilvY 960396 ilvY Escherichia coli O157:H7 str. EDL933 IlvY family transcriptional regulator NP_290404.1 4819358 R 155864 CDS NP_290405.1 15804365 960395 4820401..4821876 1 NC_002655.2 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 4821876 ilvC 960395 ilvC Escherichia coli O157:H7 str. EDL933 ketol-acid reductoisomerase NP_290405.1 4820401 D 155864 CDS NP_290406.1 15804366 960394 complement(4821922..4822203) 1 NC_002655.2 peptidyl-prolyl cis-trans isomerase C 4822203 ppiC 960394 ppiC Escherichia coli O157:H7 str. EDL933 peptidyl-prolyl cis-trans isomerase C NP_290406.1 4821922 R 155864 CDS NP_290407.1 15804367 960393 complement(4822402..4822893) 1 NC_002655.2 hypothetical protein 4822893 960393 Z5287 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290407.1 4822402 R 155864 CDS NP_290408.1 15804368 960392 4823068..4825089 1 NC_002655.2 single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication; ATP-dependent DNA helicase Rep 4825089 rep 960392 rep Escherichia coli O157:H7 str. EDL933 ATP-dependent DNA helicase Rep NP_290408.1 4823068 D 155864 CDS NP_290409.1 15804369 960391 complement(4825136..4826620) 1 NC_002655.2 catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation; guanosine pentaphosphate phosphohydrolase 4826620 gppA 960391 gppA Escherichia coli O157:H7 str. EDL933 guanosine pentaphosphate phosphohydrolase NP_290409.1 4825136 R 155864 CDS NP_290410.1 15804370 960390 complement(4826756..4828021) 1 NC_002655.2 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation; ATP-dependent RNA helicase RhlB 4828021 rhlB 960390 rhlB Escherichia coli O157:H7 str. EDL933 ATP-dependent RNA helicase RhlB NP_290410.1 4826756 R 155864 CDS NP_290411.1 15804371 960389 4828098..4828481 1 NC_002655.2 thioredoxin 4828481 trxA 960389 trxA Escherichia coli O157:H7 str. EDL933 thioredoxin NP_290411.1 4828098 D 155864 CDS NP_290412.1 15804372 960388 4828622..4828723 1 NC_002655.2 rho operon leader peptide 4828723 rhoL 960388 rhoL Escherichia coli O157:H7 str. EDL933 rho operon leader peptide NP_290412.1 4828622 D 155864 CDS NP_290413.1 15804373 960387 4828808..4830067 1 NC_002655.2 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 4830067 rho 960387 rho Escherichia coli O157:H7 str. EDL933 transcription termination factor Rho NP_290413.1 4828808 D 155864 CDS NP_290414.1 15804374 960386 4830077..4830295 1 NC_002655.2 No significant matches; hypothetical protein 4830295 960386 Z5294 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290414.1 4830077 D 155864 CDS NP_290415.1 15804375 960385 4830307..4831410 1 NC_002655.2 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase 4831410 rfe 960385 rfe Escherichia coli O157:H7 str. EDL933 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase NP_290415.1 4830307 D 155864 CDS NP_290416.1 15804376 960383 4831419..4832468 1 NC_002655.2 Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein; lipopolysaccharide biosynthesis protein WzzE 4832468 wzzE 960383 wzzE Escherichia coli O157:H7 str. EDL933 lipopolysaccharide biosynthesis protein WzzE NP_290416.1 4831419 D 155864 CDS NP_290417.1 15804377 960382 4832482..4833654 1 NC_002655.2 UDP-N-acetylglucosamine 2-epimerase 4833654 wecB 960382 wecB Escherichia coli O157:H7 str. EDL933 UDP-N-acetylglucosamine 2-epimerase NP_290417.1 4832482 D 155864 CDS NP_290418.1 15804378 960381 4833651..4834913 1 NC_002655.2 catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid; UDP-N-acetyl-D-mannosamine dehydrogenase 4834913 wecC 960381 wecC Escherichia coli O157:H7 str. EDL933 UDP-N-acetyl-D-mannosamine dehydrogenase NP_290418.1 4833651 D 155864 CDS NP_290419.1 15804379 960380 4834913..4835980 1 NC_002655.2 dTDP-glucose 4,6-dehydratase 4835980 rffG 960380 rffG Escherichia coli O157:H7 str. EDL933 dTDP-glucose 4,6-dehydratase NP_290419.1 4834913 D 155864 CDS NP_290420.1 15804380 960377 4835999..4836880 1 NC_002655.2 glucose-1-phosphate thymidylyltransferase 4836880 rffH 960377 rffH Escherichia coli O157:H7 str. EDL933 glucose-1-phosphate thymidylyltransferase NP_290420.1 4835999 D 155864 CDS NP_290421.1 15804381 960376 4836987..4837532 1 NC_002655.2 TDP-fucosamine acetyltransferase 4837532 wecD 960376 wecD Escherichia coli O157:H7 str. EDL933 TDP-fucosamine acetyltransferase NP_290421.1 4836987 D 155864 CDS NP_290422.1 15804382 960375 4837537..4838667 1 NC_002655.2 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase 4838667 wecE 960375 wecE Escherichia coli O157:H7 str. EDL933 TDP-4-oxo-6-deoxy-D-glucose transaminase NP_290422.1 4837537 D 155864 CDS NP_290423.1 15804383 960374 4838669..4839919 1 NC_002655.2 cytochrome 4839919 wzxE 960374 wzxE Escherichia coli O157:H7 str. EDL933 cytochrome NP_290423.1 4838669 D 155864 CDS NP_290424.1 15804384 960373 4839916..4840995 1 NC_002655.2 catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis; 4-alpha-L-fucosyltransferase 4840995 960373 Z5304 Escherichia coli O157:H7 str. EDL933 4-alpha-L-fucosyltransferase NP_290424.1 4839916 D 155864 CDS NP_290425.1 15804385 960372 4840992..4842344 1 NC_002655.2 enterobacterial common antigen polymerase; common antigen polymerase 4842344 wecF 960372 wecF Escherichia coli O157:H7 str. EDL933 common antigen polymerase NP_290425.1 4840992 D 155864 CDS NP_290426.1 15804386 960371 4842347..4843087 1 NC_002655.2 UDP-N-acetyl-D-mannosaminuronic acid transferase 4843087 wecG 960371 wecG Escherichia coli O157:H7 str. EDL933 UDP-N-acetyl-D-mannosaminuronic acid transferase NP_290426.1 4842347 D 155864 CDS NP_290427.1 15804387 960370 4843278..4844663 1 NC_002655.2 uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function; transporter 4844663 yifK 960370 yifK Escherichia coli O157:H7 str. EDL933 transporter NP_290427.1 4843278 D 155864 CDS NP_290428.1 15804388 960364 4845349..4846584 1 NC_002655.2 arylsulfatase 4846584 aslB 960364 aslB Escherichia coli O157:H7 str. EDL933 arylsulfatase NP_290428.1 4845349 D 155864 CDS NP_290429.1 15804389 960363 complement(4846753..4848408) 1 NC_002655.2 arylsulfatase 4848408 aslA 960363 aslA Escherichia coli O157:H7 str. EDL933 arylsulfatase NP_290429.1 4846753 R 155864 CDS NP_290430.1 15804390 960362 complement(4849088..4850284) 1 NC_002655.2 protoheme IX biogenesis protein 4850284 hemY 960362 hemY Escherichia coli O157:H7 str. EDL933 protoheme IX biogenesis protein NP_290430.1 4849088 R 155864 CDS NP_290431.1 15804391 960361 complement(4850287..4851486) 1 NC_002655.2 uroporphyrinogen III C-methyltransferase 4851486 hemX 960361 hemX Escherichia coli O157:H7 str. EDL933 uroporphyrinogen III C-methyltransferase NP_290431.1 4850287 R 155864 CDS NP_290432.1 15804392 960360 complement(4851508..4852248) 1 NC_002655.2 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase 4852248 hemD 960360 hemD Escherichia coli O157:H7 str. EDL933 uroporphyrinogen-III synthase NP_290432.1 4851508 R 155864 CDS NP_290433.1 15804393 960359 complement(4852245..4853207) 1 NC_002655.2 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 4853207 hemC 960359 hemC Escherichia coli O157:H7 str. EDL933 porphobilinogen deaminase NP_290433.1 4852245 R 155864 CDS NP_290434.1 15804394 960357 4853574..4856120 1 NC_002655.2 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase 4856120 cyaA 960357 cyaA Escherichia coli O157:H7 str. EDL933 adenylate cyclase NP_290434.1 4853574 D 155864 CDS NP_290435.1 15804395 960356 complement(4856160..4856480) 1 NC_002655.2 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein 4856480 cyaY 960356 cyaY Escherichia coli O157:H7 str. EDL933 frataxin-like protein NP_290435.1 4856160 R 155864 CDS NP_290436.1 15804396 960355 4856271..4856756 1 NC_002655.2 hypothetical protein 4856756 960355 Z5324 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290436.1 4856271 D 155864 CDS NP_290437.1 15804397 960354 4856943..4857146 1 NC_002655.2 No significant matches; hypothetical protein 4857146 960354 Z5325 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290437.1 4856943 D 155864 CDS NP_290438.2 161367483 960353 4857183..4858007 1 NC_002655.2 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 4858007 dapF 960353 dapF Escherichia coli O157:H7 str. EDL933 diaminopimelate epimerase NP_290438.2 4857183 D 155864 CDS NP_290439.1 15804399 960352 4858004..4858711 1 NC_002655.2 hypothetical protein 4858711 yigA 960352 yigA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290439.1 4858004 D 155864 CDS NP_290440.1 15804400 960351 4858708..4859604 1 NC_002655.2 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 4859604 xerC 960351 xerC Escherichia coli O157:H7 str. EDL933 site-specific tyrosine recombinase XerC NP_290440.1 4858708 D 155864 CDS NP_290441.1 15804401 960350 4859604..4860320 1 NC_002655.2 YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function; flavin mononucleotide phosphatase 4860320 yigB 960350 yigB Escherichia coli O157:H7 str. EDL933 flavin mononucleotide phosphatase NP_290441.1 4859604 D 155864 CDS NP_290442.1 15804402 960349 4860404..4862566 1 NC_002655.2 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II 4862566 uvrD 960349 uvrD Escherichia coli O157:H7 str. EDL933 DNA-dependent helicase II NP_290442.1 4860404 D 155864 CDS NP_290443.1 15804403 960348 complement(4862611..4863513) 1 NC_002655.2 hypothetical protein 4863513 960348 Z5331 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290443.1 4862611 R 155864 CDS NP_290444.1 15804404 960347 complement(4863596..4864360) 1 NC_002655.2 hypothetical protein 4864360 960347 Z5332 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290444.1 4863596 R 155864 CDS NP_290445.1 15804405 960346 4864730..4865680 1 NC_002655.2 responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA 4865680 corA 960346 corA Escherichia coli O157:H7 str. EDL933 magnesium/nickel/cobalt transporter CorA NP_290445.1 4864730 D 155864 CDS NP_290446.1 15804406 960345 complement(4865722..4866213) 1 NC_002655.2 No significant matches; hypothetical protein 4866213 960345 Z5334 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290446.1 4865722 R 155864 CDS NP_290447.1 15804407 960344 complement(4866210..4867058) 1 NC_002655.2 No significant matches; hypothetical protein 4867058 960344 Z5335 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290447.1 4866210 R 155864 CDS NP_290448.1 15804408 960343 4867272..4867391 1 NC_002655.2 magnesium/cobalt transporter CorA 4867391 960343 Z5336 Escherichia coli O157:H7 str. EDL933 magnesium/cobalt transporter CorA NP_290448.1 4867272 D 155864 CDS NP_290449.1 15804409 960342 complement(4867416..4867802) 1 NC_002655.2 No significant matches; hypothetical protein 4867802 960342 Z5337 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290449.1 4867416 R 155864 CDS NP_290450.1 15804410 960341 4868007..4868318 1 NC_002655.2 No significant matches; hypothetical protein 4868318 960341 Z5339 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290450.1 4868007 D 155864 CDS NP_290451.1 15804411 960340 complement(4868365..4869252) 1 NC_002655.2 hypothetical protein 4869252 rarD 960340 rarD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290451.1 4868365 R 155864 CDS NP_290452.2 161367482 960339 complement(4869304..4869771) 1 NC_002655.2 hypothetical protein 4869771 yigI 960339 yigI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290452.2 4869304 R 155864 CDS NP_290453.1 15804413 960338 4869936..4870805 1 NC_002655.2 catalyzes the hydrolysis of phosphatidylcholine; phospholipase A 4870805 pldA 960338 pldA Escherichia coli O157:H7 str. EDL933 phospholipase A NP_290453.1 4869936 D 155864 CDS NP_290454.1 15804414 960337 4870932..4872767 1 NC_002655.2 functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway; ATP-dependent DNA helicase RecQ 4872767 recQ 960337 recQ Escherichia coli O157:H7 str. EDL933 ATP-dependent DNA helicase RecQ NP_290454.1 4870932 D 155864 CDS NP_290455.1 15804415 960336 4873083..4873451 1 NC_002655.2 hypothetical protein 4873451 yigJ 960336 yigJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290455.1 4873083 D 155864 CDS NP_290456.1 15804416 960335 complement(4873513..4873929) 1 NC_002655.2 hypothetical protein 4873929 yigK 960335 yigK Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290456.1 4873513 R 155864 CDS NP_290457.1 15804417 960333 4874244..4875266 1 NC_002655.2 lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates; lysophospholipase L2 4875266 pldB 960333 pldB Escherichia coli O157:H7 str. EDL933 lysophospholipase L2 NP_290457.1 4874244 D 155864 CDS NP_290458.1 15804418 960332 4875157..4876074 1 NC_002655.2 purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium; sugar phosphatase 4876074 960332 Z5347 Escherichia coli O157:H7 str. EDL933 sugar phosphatase NP_290458.1 4875157 D 155864 CDS NP_290459.1 15804419 960331 4876150..4877049 1 NC_002655.2 hypothetical protein 4877049 yigM 960331 yigM Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290459.1 4876150 D 155864 CDS NP_290460.1 15804420 960330 complement(4876937..4877890) 1 NC_002655.2 regulator for metE and metH 4877890 metR 960330 metR Escherichia coli O157:H7 str. EDL933 regulator for metE and metH NP_290460.1 4876937 R 155864 CDS NP_290461.1 15804421 960329 4878126..4880387 1 NC_002655.2 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 4880387 metE 960329 metE Escherichia coli O157:H7 str. EDL933 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase NP_290461.1 4878126 D 155864 CDS NP_290462.1 15804422 960328 complement(4880427..4881308) 1 NC_002655.2 hypothetical protein 4881308 960328 Z5352 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290462.1 4880427 R 155864 CDS NP_290463.1 15804423 960327 4881504..4882265 1 NC_002655.2 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase 4882265 udp 960327 udp Escherichia coli O157:H7 str. EDL933 uridine phosphorylase NP_290463.1 4881504 D 155864 CDS NP_290464.1 15804424 960326 4882406..4883833 1 NC_002655.2 YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner; DNA recombination protein RmuC 4883833 yigN 960326 yigN Escherichia coli O157:H7 str. EDL933 DNA recombination protein RmuC NP_290464.1 4882406 D 155864 CDS NP_290465.1 15804425 960325 4883928..4884683 1 NC_002655.2 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 4884683 ubiE 960325 ubiE Escherichia coli O157:H7 str. EDL933 ubiquinone/menaquinone biosynthesis methyltransferase NP_290465.1 4883928 D 155864 CDS NP_290466.1 15804426 960324 4884697..4885302 1 NC_002655.2 hypothetical protein 4885302 yigP 960324 yigP Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290466.1 4884697 D 155864 CDS NP_290467.1 15804427 960323 4885299..4886939 1 NC_002655.2 an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions; ubiquinone biosynthesis protein UbiB 4886939 ubiB 960323 ubiB Escherichia coli O157:H7 str. EDL933 ubiquinone biosynthesis protein UbiB NP_290467.1 4885299 D 155864 CDS NP_290468.1 15804428 960322 4886976..4887287 1 NC_002655.2 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin-arginine translocation protein TatA 4887287 tatA 960322 tatA Escherichia coli O157:H7 str. EDL933 twin-arginine translocation protein TatA NP_290468.1 4886976 D 155864 CDS NP_290469.2 161367481 960321 4887291..4887806 1 NC_002655.2 mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 4887806 tatB 960321 tatB Escherichia coli O157:H7 str. EDL933 sec-independent translocase NP_290469.2 4887291 D 155864 CDS NP_290470.1 15804430 960320 4887809..4888585 1 NC_002655.2 with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane; twin-arginine protein translocation system subunit TatC 4888585 tatC 960320 tatC Escherichia coli O157:H7 str. EDL933 twin-arginine protein translocation system subunit TatC NP_290470.1 4887809 D 155864 CDS NP_290471.1 15804431 960319 4888615..4889409 1 NC_002655.2 magnesium dependent; not involved in the Sec-independent protein export system; DNase TatD 4889409 tatD 960319 tatD Escherichia coli O157:H7 str. EDL933 DNase TatD NP_290471.1 4888615 D 155864 CDS NP_290472.1 15804432 960318 complement(4889406..4889894) 1 NC_002655.2 transcriptional activator RfaH 4889894 rfaH 960318 rfaH Escherichia coli O157:H7 str. EDL933 transcriptional activator RfaH NP_290472.1 4889406 R 155864 CDS NP_290473.1 15804433 960317 4890061..4891554 1 NC_002655.2 catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 4891554 yigC 960317 yigC Escherichia coli O157:H7 str. EDL933 3-octaprenyl-4-hydroxybenzoate carboxy-lyase NP_290473.1 4890061 D 155864 CDS NP_290474.1 15804434 960316 4891600..4892301 1 NC_002655.2 NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin; FMN reductase 4892301 fre 960316 fre Escherichia coli O157:H7 str. EDL933 FMN reductase NP_290474.1 4891600 D 155864 CDS NP_290475.1 15804435 960315 complement(4892493..4893656) 1 NC_002655.2 FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; 3-ketoacyl-CoA thiolase 4893656 fadA 960315 fadA Escherichia coli O157:H7 str. EDL933 3-ketoacyl-CoA thiolase NP_290475.1 4892493 R 155864 CDS NP_290476.1 15804436 960314 complement(4893666..4895855) 1 NC_002655.2 includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; multifunctional fatty acid oxidation complex subunit alpha 4895855 fadB 960314 fadB Escherichia coli O157:H7 str. EDL933 multifunctional fatty acid oxidation complex subunit alpha NP_290476.1 4893666 R 155864 CDS NP_290477.1 15804437 960313 4896045..4897376 1 NC_002655.2 catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters; proline dipeptidase 4897376 pepQ 960313 pepQ Escherichia coli O157:H7 str. EDL933 proline dipeptidase NP_290477.1 4896045 D 155864 CDS NP_290478.1 15804438 960312 4897373..4897990 1 NC_002655.2 hypothetical protein 4897990 yigZ 960312 yigZ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290478.1 4897373 D 155864 CDS NP_290479.1 15804439 960311 4898029..4899480 1 NC_002655.2 potassium transporter 4899480 trkH 960311 trkH Escherichia coli O157:H7 str. EDL933 potassium transporter NP_290479.1 4898029 D 155864 CDS NP_290480.1 15804440 960310 4899492..4900037 1 NC_002655.2 catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX; protoporphyrinogen oxidase 4900037 hemG 960310 hemG Escherichia coli O157:H7 str. EDL933 protoporphyrinogen oxidase NP_290480.1 4899492 D 155864 CDS NP_290481.1 15804441 960304 complement(4905622..4906134) 1 NC_002655.2 in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway; molybdopterin-guanine dinucleotide biosynthesis protein B 4906134 mobB 960304 mobB Escherichia coli O157:H7 str. EDL933 molybdopterin-guanine dinucleotide biosynthesis protein B NP_290481.1 4905622 R 155864 CDS NP_290482.1 15804442 960303 complement(4906131..4906715) 1 NC_002655.2 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein MobA 4906715 mobA 960303 mobA Escherichia coli O157:H7 str. EDL933 molybdopterin-guanine dinucleotide biosynthesis protein MobA NP_290482.1 4906131 R 155864 CDS NP_290483.1 15804443 960302 4906785..4907054 1 NC_002655.2 hypothetical protein 4907054 yihD 960302 yihD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290483.1 4906785 D 155864 CDS NP_290484.1 15804444 960301 4907131..4908117 1 NC_002655.2 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages; serine/threonine protein kinase 4908117 yihE 960301 yihE Escherichia coli O157:H7 str. EDL933 serine/threonine protein kinase NP_290484.1 4907131 D 155864 CDS NP_290485.1 15804445 960300 4908134..4908760 1 NC_002655.2 protein disulfide isomerase 4908760 dsbA 960300 dsbA Escherichia coli O157:H7 str. EDL933 protein disulfide isomerase NP_290485.1 4908134 D 155864 CDS NP_290486.1 15804446 960299 4908873..4910345 1 NC_002655.2 hypothetical protein 4910345 yihF 960299 yihF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290486.1 4908873 D 155864 CDS NP_290487.1 15804447 960298 complement(4910386..4911318) 1 NC_002655.2 acyltransferase 4911318 yihG 960298 yihG Escherichia coli O157:H7 str. EDL933 acyltransferase NP_290487.1 4910386 R 155864 CDS NP_290488.1 15804448 960297 4911682..4914468 1 NC_002655.2 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 4914468 polA 960297 polA Escherichia coli O157:H7 str. EDL933 DNA polymerase I NP_290488.1 4911682 D 155864 CDS NP_290489.2 161367480 960295 complement(4914850..4915482) 1 NC_002655.2 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 4915482 engB 960295 engB Escherichia coli O157:H7 str. EDL933 ribosome biogenesis GTP-binding protein YsxC NP_290489.2 4914850 R 155864 CDS NP_290491.1 15804451 960293 4916064..4916570 1 NC_002655.2 hypothetical protein 4916570 yihI 960293 yihI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290491.1 4916064 D 155864 CDS NP_290492.2 161367479 960292 4916759..4918132 1 NC_002655.2 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 4918132 hemN 960292 hemN Escherichia coli O157:H7 str. EDL933 coproporphyrinogen III oxidase NP_290492.2 4916759 D 155864 CDS NP_290493.1 15804453 960291 complement(4918544..4919953) 1 NC_002655.2 response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54; nitrogen regulation protein NR(I) 4919953 glnG 960291 glnG Escherichia coli O157:H7 str. EDL933 nitrogen regulation protein NR(I) NP_290493.1 4918544 R 155864 CDS NP_290494.1 15804454 960290 complement(4919965..4921014) 1 NC_002655.2 sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation; nitrogen regulation protein NR(II) 4921014 glnL 960290 glnL Escherichia coli O157:H7 str. EDL933 nitrogen regulation protein NR(II) NP_290494.1 4919965 R 155864 CDS NP_290495.1 15804455 960289 complement(4921188..4922597) 1 NC_002655.2 forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; glutamine synthetase 4922597 glnA 960289 glnA Escherichia coli O157:H7 str. EDL933 glutamine synthetase NP_290495.1 4921188 R 155864 CDS NP_290496.1 15804456 960288 4922970..4924793 1 NC_002655.2 GTP-binding protein 4924793 yihK 960288 yihK Escherichia coli O157:H7 str. EDL933 GTP-binding protein NP_290496.1 4922970 D 155864 CDS NP_290497.1 15804457 960287 4925010..4925720 1 NC_002655.2 transcriptional regulator 4925720 yihL 960287 yihL Escherichia coli O157:H7 str. EDL933 transcriptional regulator NP_290497.1 4925010 D 155864 CDS NP_290498.1 15804458 960286 4925728..4926708 1 NC_002655.2 hypothetical protein 4926708 yihM 960286 yihM Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290498.1 4925728 D 155864 CDS NP_290499.1 15804459 960285 4926810..4928075 1 NC_002655.2 resistance protein (transport) 4928075 yihN 960285 yihN Escherichia coli O157:H7 str. EDL933 resistance protein (transport) NP_290499.1 4926810 D 155864 CDS NP_290500.2 228979040 960284 complement(4928166..4928858) 1 NC_002655.2 porin involved in the transport of small molecular weight solutes (up to 600 Daltons) across the cell wall; specific substrate still unknown; porin 4928858 ompL 960284 ompL Escherichia coli O157:H7 str. EDL933 porin NP_290500.2 4928166 R 155864 CDS NP_290501.1 15804461 960283 complement(4928925..4930334) 1 NC_002655.2 permease 4930334 yihO 960283 yihO Escherichia coli O157:H7 str. EDL933 permease NP_290501.1 4928925 R 155864 CDS NP_290502.1 15804462 960282 complement(4930371..4931756) 1 NC_002655.2 permease 4931756 yihP 960282 yihP Escherichia coli O157:H7 str. EDL933 permease NP_290502.1 4930371 R 155864 CDS NP_290503.1 15804463 960281 complement(4931802..4933838) 1 NC_002655.2 alpha-glucosidase 4933838 yihQ 960281 yihQ Escherichia coli O157:H7 str. EDL933 alpha-glucosidase NP_290503.1 4931802 R 155864 CDS NP_290504.1 15804464 960280 complement(4933946..4934821) 1 NC_002655.2 hypothetical protein 4934821 960280 Z5415 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290504.1 4933946 R 155864 CDS NP_290505.1 15804465 960279 complement(4934882..4935784) 1 NC_002655.2 aldose-1-epimerase 4935784 yihR 960279 yihR Escherichia coli O157:H7 str. EDL933 aldose-1-epimerase NP_290505.1 4934882 R 155864 CDS NP_290506.1 15804466 960276 complement(4935851..4937092) 1 NC_002655.2 hypothetical protein 4937092 yihS 960276 yihS Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290506.1 4935851 R 155864 CDS NP_290507.1 15804467 960275 complement(4937108..4937986) 1 NC_002655.2 aldolase 4937986 yihT 960275 yihT Escherichia coli O157:H7 str. EDL933 aldolase NP_290507.1 4937108 R 155864 CDS NP_290508.1 15804468 960274 complement(4938010..4938906) 1 NC_002655.2 dehydrogenase 4938906 yihU 960274 yihU Escherichia coli O157:H7 str. EDL933 dehydrogenase NP_290508.1 4938010 R 155864 CDS NP_290509.1 15804469 960273 4939068..4939970 1 NC_002655.2 kinase 4939970 yihV 960273 yihV Escherichia coli O157:H7 str. EDL933 kinase NP_290509.1 4939068 D 155864 CDS NP_290510.1 15804470 960272 4939980..4940789 1 NC_002655.2 DEOR-type transcriptional activator 4940789 yihW 960272 yihW Escherichia coli O157:H7 str. EDL933 DEOR-type transcriptional activator NP_290510.1 4939980 D 155864 CDS NP_290511.2 161367478 960270 4940888..4941487 1 NC_002655.2 phosphatase 4941487 yihX 960270 yihX Escherichia coli O157:H7 str. EDL933 phosphatase NP_290511.2 4940888 D 155864 CDS NP_290512.1 15804472 960269 4941481..4942353 1 NC_002655.2 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN 4942353 rbn 960269 rbn Escherichia coli O157:H7 str. EDL933 ribonuclease BN NP_290512.1 4941481 D 155864 CDS NP_290513.1 15804473 960268 4942350..4942787 1 NC_002655.2 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 4942787 yihZ 960268 yihZ Escherichia coli O157:H7 str. EDL933 D-tyrosyl-tRNA(Tyr) deacylase NP_290513.1 4942350 D 155864 CDS NP_290514.1 15804474 960267 4942784..4943773 1 NC_002655.2 acetyltransferase 4943773 yiiD 960267 yiiD Escherichia coli O157:H7 str. EDL933 acetyltransferase NP_290514.1 4942784 D 155864 CDS NP_290515.1 15804475 960266 4944085..4945077 1 NC_002655.2 No significant matches; hypothetical protein 4945077 960266 Z5428 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290515.1 4944085 D 155864 CDS NP_290516.1 15804476 960265 4945084..4945998 1 NC_002655.2 No significant matches; hypothetical protein 4945998 960265 Z5429 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290516.1 4945084 D 155864 CDS NP_290517.1 15804477 960264 complement(4946391..4946507) 1 NC_002655.2 No significant matches; hypothetical protein 4946507 960264 Z5430 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290517.1 4946391 R 155864 CDS NP_290518.1 15804478 960263 4946665..4946910 1 NC_002655.2 hypothetical protein 4946910 yiiE 960263 yiiE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290518.1 4946665 D 155864 CDS NP_290519.1 15804479 960262 4947127..4947369 1 NC_002655.2 hypothetical protein 4947369 yiiF 960262 yiiF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290519.1 4947127 D 155864 CDS NP_290520.1 15804480 960261 complement(4947699..4948628) 1 NC_002655.2 required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE 4948628 fdhE 960261 fdhE Escherichia coli O157:H7 str. EDL933 formate dehydrogenase accessory protein FdhE NP_290520.1 4947699 R 155864 CDS NP_290521.1 15804481 960260 complement(4948625..4949260) 1 NC_002655.2 cytochrome b556(FDO) component; heme containing; formate dehydrogenase-O subunit gamma 4949260 fdoI 960260 fdoI Escherichia coli O157:H7 str. EDL933 formate dehydrogenase-O subunit gamma NP_290521.1 4948625 R 155864 CDS NP_290522.1 15804482 960259 complement(4949257..4950159) 1 NC_002655.2 formate dehydrogenase-O, iron-sulfur subunit 4950159 fdoH 960259 fdoH Escherichia coli O157:H7 str. EDL933 formate dehydrogenase-O, iron-sulfur subunit NP_290522.1 4949257 R 155864 CDS NP_290523.1 15804483 960258 complement(4950172..4953222) 1 NC_002655.2 formate dehydrogenase-O, major subunit 4953222 fdoG 960258 fdoG Escherichia coli O157:H7 str. EDL933 formate dehydrogenase-O, major subunit NP_290523.1 4950172 R 155864 CDS NP_290524.1 15804484 960257 4953416..4954249 1 NC_002655.2 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 4954249 fdhD 960257 fdhD Escherichia coli O157:H7 str. EDL933 formate dehydrogenase accessory protein NP_290524.1 4953416 D 155864 CDS NP_290525.1 15804485 960256 4954402..4955457 1 NC_002655.2 hypothetical protein 4955457 yiiG 960256 yiiG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290525.1 4954402 D 155864 CDS NP_290526.1 15804486 960255 complement(4955507..4957255) 1 NC_002655.2 repressor of the frv operon, involved in phosphoenolpyruvate:sugar phosphotransferase system; frv operon regulatory protein 4957255 frvR 960255 frvR Escherichia coli O157:H7 str. EDL933 frv operon regulatory protein NP_290526.1 4955507 R 155864 CDS NP_290527.1 15804487 960254 complement(4957255..4958325) 1 NC_002655.2 with FrvABR is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system which may be involved in the transport and phosphorylation of sugars; fructose-specific phosphotransferase system protein FrvX 4958325 frvX 960254 frvX Escherichia coli O157:H7 str. EDL933 fructose-specific phosphotransferase system protein FrvX NP_290527.1 4957255 R 155864 CDS NP_290528.1 15804488 960253 complement(4958315..4959760) 1 NC_002655.2 PTS system transporter subunits IIBC 4959760 frvB 960253 frvB Escherichia coli O157:H7 str. EDL933 PTS system transporter subunits IIBC NP_290528.1 4958315 R 155864 CDS NP_290529.1 15804489 960251 complement(4959765..4960211) 1 NC_002655.2 with FrvBRX is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system involved in the transport and phosphorylation of sugars; possibly responsible for the sugar specificity of the system; fructose-like phosphotransferase system subunit EIIA 4960211 frvA 960251 frvA Escherichia coli O157:H7 str. EDL933 fructose-like phosphotransferase system subunit EIIA NP_290529.1 4959765 R 155864 CDS NP_290530.1 15804490 960248 4960689..4962083 1 NC_002655.2 glycoporin 4962083 960248 Z5444 Escherichia coli O157:H7 str. EDL933 glycoporin NP_290530.1 4960689 D 155864 CDS NP_290531.1 15804491 960247 complement(4962124..4962438) 1 NC_002655.2 hypothetical protein 4962438 yiiL 960247 yiiL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290531.1 4962124 R 155864 CDS NP_290532.1 15804492 960246 complement(4962448..4963272) 1 NC_002655.2 rhamnulose-1-phosphate aldolase 4963272 rhaD 960246 rhaD Escherichia coli O157:H7 str. EDL933 rhamnulose-1-phosphate aldolase NP_290532.1 4962448 R 155864 CDS NP_290533.1 15804493 960245 complement(4963447..4964706) 1 NC_002655.2 catalyzes the formation of L-rhamnulose from L-rhamnose; L-rhamnose isomerase 4964706 rhaA 960245 rhaA Escherichia coli O157:H7 str. EDL933 L-rhamnose isomerase NP_290533.1 4963447 R 155864 CDS NP_290534.1 15804494 960244 complement(4964703..4966172) 1 NC_002655.2 catalyzes the ATP-dependent phosphorylation of rhamnulose; rhamnulokinase 4966172 rhaB 960244 rhaB Escherichia coli O157:H7 str. EDL933 rhamnulokinase NP_290534.1 4964703 R 155864 CDS NP_290535.1 15804495 960241 4966460..4967296 1 NC_002655.2 activates the expression of the rhaBAD operon and rhaT gene; transcriptional activator RhaS 4967296 rhaS 960241 rhaS Escherichia coli O157:H7 str. EDL933 transcriptional activator RhaS NP_290535.1 4966460 D 155864 CDS NP_290536.1 15804496 960240 4967280..4968218 1 NC_002655.2 activates the expression of rhaRS in response to L-rhamnose; transcriptional activator RhaR 4968218 rhaR 960240 rhaR Escherichia coli O157:H7 str. EDL933 transcriptional activator RhaR NP_290536.1 4967280 D 155864 CDS NP_290537.1 15804497 960238 complement(4968215..4969006) 1 NC_002655.2 rhamnose transport 4969006 rhaT 960238 rhaT Escherichia coli O157:H7 str. EDL933 rhamnose transport NP_290537.1 4968215 R 155864 CDS NP_290538.1 15804498 960237 4969534..4970154 1 NC_002655.2 SodA; manganese binding; only present under aerobic conditions; destroys free radicals; superoxide dismutase 4970154 sodA 960237 sodA Escherichia coli O157:H7 str. EDL933 superoxide dismutase NP_290538.1 4969534 D 155864 CDS NP_290539.2 161367477 960236 4970414..4971397 1 NC_002655.2 transports degraded pectin products into the bacterial cell; 2-keto-3-deoxygluconate permease 4971397 kdgT 960236 kdgT Escherichia coli O157:H7 str. EDL933 2-keto-3-deoxygluconate permease NP_290539.2 4970414 D 155864 CDS NP_290540.2 161367476 960235 4971546..4972220 1 NC_002655.2 hypothetical protein 4972220 yiiM 960235 yiiM Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290540.2 4971546 D 155864 CDS NP_290541.1 15804501 960234 complement(4972326..4973699) 1 NC_002655.2 part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; two-component sensor protein 4973699 cpxA 960234 cpxA Escherichia coli O157:H7 str. EDL933 two-component sensor protein NP_290541.1 4972326 R 155864 CDS NP_290542.1 15804502 960233 complement(4973696..4974394) 1 NC_002655.2 response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; DNA-binding transcriptional regulator CpxR 4974394 cpxR 960233 cpxR Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator CpxR NP_290542.1 4973696 R 155864 CDS NP_290543.2 161367475 960232 4974544..4975044 1 NC_002655.2 repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates; repressor CpxP 4975044 cpxP 960232 cpxP Escherichia coli O157:H7 str. EDL933 repressor CpxP NP_290543.2 4974544 D 155864 CDS NP_290544.1 15804504 960230 4975193..4976095 1 NC_002655.2 member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers; ferrous iron efflux protein F 4976095 fieF 960230 fieF Escherichia coli O157:H7 str. EDL933 ferrous iron efflux protein F NP_290544.1 4975193 D 155864 CDS NP_290545.1 15804505 960228 4976276..4977238 1 NC_002655.2 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 4977238 pfkA 960228 pfkA Escherichia coli O157:H7 str. EDL933 6-phosphofructokinase NP_290545.1 4976276 D 155864 CDS NP_290546.1 15804506 960227 4977557..4978546 1 NC_002655.2 sulfate transporter subunit 4978546 sbp 960227 sbp Escherichia coli O157:H7 str. EDL933 sulfate transporter subunit NP_290546.1 4977557 D 155864 CDS NP_290547.1 15804507 960226 4978653..4979408 1 NC_002655.2 CDP-diacylglycerol pyrophosphatase 4979408 cdh 960226 cdh Escherichia coli O157:H7 str. EDL933 CDP-diacylglycerol pyrophosphatase NP_290547.1 4978653 D 155864 CDS NP_290548.1 15804508 960224 complement(4979463..4980230) 1 NC_002655.2 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 4980230 tpiA 960224 tpiA Escherichia coli O157:H7 str. EDL933 triosephosphate isomerase NP_290548.1 4979463 R 155864 CDS NP_290549.1 15804509 960223 complement(4980338..4980937) 1 NC_002655.2 hypothetical protein 4980937 yiiQ 960223 yiiQ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290549.1 4980338 R 155864 CDS NP_290550.1 15804510 960222 4981038..4981478 1 NC_002655.2 hypothetical protein 4981478 yiiR 960222 yiiR Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290550.1 4981038 D 155864 CDS NP_290551.1 15804511 960220 4981690..4981989 1 NC_002655.2 hypothetical protein 4981989 yiiS 960220 yiiS Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290551.1 4981690 D 155864 CDS NP_290552.1 15804512 960217 4982016..4982444 1 NC_002655.2 with UspC and Usp E is involved in resistance to UV radiation; universal stress protein UspD 4982444 yiiT 960217 yiiT Escherichia coli O157:H7 str. EDL933 universal stress protein UspD NP_290552.1 4982016 D 155864 CDS NP_290553.1 15804513 960215 complement(4982449..4983195) 1 NC_002655.2 ferredoxin-NADP reductase 4983195 fpr 960215 fpr Escherichia coli O157:H7 str. EDL933 ferredoxin-NADP reductase NP_290553.1 4982449 R 155864 CDS NP_290554.1 15804514 960214 complement(4983292..4984302) 1 NC_002655.2 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 4984302 glpX 960214 glpX Escherichia coli O157:H7 str. EDL933 fructose 1,6-bisphosphatase II NP_290554.1 4983292 R 155864 CDS NP_290555.1 15804515 960213 complement(4984532..4986061) 1 NC_002655.2 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 4986061 glpK 960213 glpK Escherichia coli O157:H7 str. EDL933 glycerol kinase NP_290555.1 4984532 R 155864 CDS NP_290556.1 15804516 960212 complement(4986063..4986908) 1 NC_002655.2 facilitated diffusion of glycerol 4986908 glpF 960212 glpF Escherichia coli O157:H7 str. EDL933 facilitated diffusion of glycerol NP_290556.1 4986063 R 155864 CDS NP_290557.1 15804517 960211 4987334..4987579 1 NC_002655.2 hypothetical protein 4987579 yiiU 960211 yiiU Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290557.1 4987334 D 155864 CDS NP_290558.1 15804518 960210 complement(4987618..4988334) 1 NC_002655.2 No significant matches; hypothetical protein 4988334 960210 Z5474 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290558.1 4987618 R 155864 CDS NP_290559.1 15804519 960209 complement(4988367..4989053) 1 NC_002655.2 No significant matches; hypothetical protein 4989053 960209 Z5475 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290559.1 4988367 R 155864 CDS NP_290560.1 15804520 960208 complement(4989101..4989586) 1 NC_002655.2 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 4989586 menG 960208 menG Escherichia coli O157:H7 str. EDL933 ribonuclease activity regulator protein RraA NP_290560.1 4989101 R 155864 CDS NP_290561.1 15804521 960207 complement(4989679..4990605) 1 NC_002655.2 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 4990605 menA 960207 menA Escherichia coli O157:H7 str. EDL933 1,4-dihydroxy-2-naphthoate octaprenyltransferase NP_290561.1 4989679 R 155864 CDS NP_290562.1 15804522 960206 complement(4990672..4992003) 1 NC_002655.2 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 4992003 hslU 960206 hslU Escherichia coli O157:H7 str. EDL933 ATP-dependent protease ATP-binding subunit HslU NP_290562.1 4990672 R 155864 CDS NP_290563.1 15804523 960205 complement(4992013..4992543) 1 NC_002655.2 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 4992543 hslV 960205 hslV Escherichia coli O157:H7 str. EDL933 ATP-dependent protease peptidase subunit NP_290563.1 4992013 R 155864 CDS NP_290564.1 15804524 960204 complement(4992636..4993595) 1 NC_002655.2 cell division protein FtsN 4993595 ftsN 960204 ftsN Escherichia coli O157:H7 str. EDL933 cell division protein FtsN NP_290564.1 4992636 R 155864 CDS NP_290565.1 15804525 960203 complement(4993687..4994712) 1 NC_002655.2 negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins; DNA-binding transcriptional regulator CytR 4994712 cytR 960203 cytR Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator CytR NP_290565.1 4993687 R 155864 CDS NP_290566.1 15804526 960202 complement(4994868..4997066) 1 NC_002655.2 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 4997066 priA 960202 priA Escherichia coli O157:H7 str. EDL933 primosome assembly protein PriA NP_290566.1 4994868 R 155864 CDS NP_290567.1 15804527 960201 4997269..4997481 1 NC_002655.2 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 4997481 rpmE 960201 rpmE Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L31 NP_290567.1 4997269 D 155864 CDS NP_290568.1 15804528 960200 4997641..4998210 1 NC_002655.2 hypothetical protein 4998210 960200 Z5485 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290568.1 4997641 D 155864 CDS NP_290569.1 15804529 960199 4998089..4998790 1 NC_002655.2 hypothetical protein 4998790 960199 Z5487 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290569.1 4998089 D 155864 CDS NP_290570.1 15804530 960198 4998870..5001827 1 NC_002655.2 hypothetical protein 5001827 960198 Z5488 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290570.1 4998870 D 155864 CDS NP_290571.1 15804531 960197 5001829..5002065 1 NC_002655.2 hypothetical protein 5002065 960197 Z5489 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290571.1 5001829 D 155864 CDS NP_290572.1 15804532 960196 5002118..5002396 1 NC_002655.2 No significant matches; hypothetical protein 5002396 960196 Z5490 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290572.1 5002118 D 155864 CDS NP_290573.1 15804533 960195 complement(5002429..5002614) 1 NC_002655.2 hypothetical protein 5002614 960195 Z5491 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290573.1 5002429 R 155864 CDS NP_290574.1 15804534 960194 complement(5003058..5003666) 1 NC_002655.2 member of the NlpC/P60 superfamily of peptidases; peptidoglycan peptidase 5003666 yiiX 960194 yiiX Escherichia coli O157:H7 str. EDL933 peptidoglycan peptidase NP_290574.1 5003058 R 155864 CDS NP_290575.1 15804535 960193 complement(5003726..5004043) 1 NC_002655.2 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ 5004043 metJ 960193 metJ Escherichia coli O157:H7 str. EDL933 transcriptional repressor protein MetJ NP_290575.1 5003726 R 155864 CDS NP_290576.1 15804536 960192 5004320..5005480 1 NC_002655.2 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 5005480 metB 960192 metB Escherichia coli O157:H7 str. EDL933 cystathionine gamma-synthase NP_290576.1 5004320 D 155864 CDS NP_290577.1 15804537 960191 5005483..5007915 1 NC_002655.2 multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartate kinase II/homoserine dehydrogenase II 5007915 metL 960191 metL Escherichia coli O157:H7 str. EDL933 bifunctional aspartate kinase II/homoserine dehydrogenase II NP_290577.1 5005483 D 155864 CDS NP_290578.1 15804538 960190 5008264..5009154 1 NC_002655.2 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 5009154 metF 960190 metF Escherichia coli O157:H7 str. EDL933 5,10-methylenetetrahydrofolate reductase NP_290578.1 5008264 D 155864 CDS NP_290579.1 15804539 960189 5009483..5011663 1 NC_002655.2 catalase 5011663 katG 960189 katG Escherichia coli O157:H7 str. EDL933 catalase NP_290579.1 5009483 D 155864 CDS NP_290580.1 15804540 960188 5011724..5012662 1 NC_002655.2 hypothetical protein 5012662 yijE 960188 yijE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290580.1 5011724 D 155864 CDS NP_290581.1 15804541 960187 complement(5012689..5013306) 1 NC_002655.2 hypothetical protein 5013306 yijF 960187 yijF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290581.1 5012689 R 155864 CDS NP_290582.2 161367474 960186 complement(5013580..5014683) 1 NC_002655.2 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 5014683 gldA 960186 gldA Escherichia coli O157:H7 str. EDL933 glycerol dehydrogenase NP_290582.2 5013580 R 155864 CDS NP_290583.1 15804543 960185 complement(5014694..5015356) 1 NC_002655.2 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 5015356 talC 960185 talC Escherichia coli O157:H7 str. EDL933 fructose-6-phosphate aldolase NP_290583.1 5014694 R 155864 CDS NP_290584.1 15804544 960184 complement(5015368..5017503) 1 NC_002655.2 PEP-protein phosphotransferase system enzyme I 5017503 ptsA 960184 ptsA Escherichia coli O157:H7 str. EDL933 PEP-protein phosphotransferase system enzyme I NP_290584.1 5015368 R 155864 CDS NP_290585.1 15804545 960183 5017505..5017969 1 NC_002655.2 hypothetical protein 5017969 yijI 960183 yijI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290585.1 5017505 D 155864 CDS NP_290586.1 15805000 959634 5018178..5019257 1 NC_002655.2 FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site; fructose-like permease EIIC subunit 2 5019257 frwC 959634 frwC Escherichia coli O157:H7 str. EDL933 fructose-like permease EIIC subunit 2 NP_290586.1 5018178 D 155864 CDS NP_290587.1 15804546 960182 5019272..5019592 1 NC_002655.2 FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS; PTS system fructose-like transporter subunit EIIB 5019592 frwB 960182 frwB Escherichia coli O157:H7 str. EDL933 PTS system fructose-like transporter subunit EIIB NP_290587.1 5019272 D 155864 CDS NP_290588.1 15804547 960181 5019643..5021940 1 NC_002655.2 involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein; formate acetyltransferase 2 5021940 pflD 960181 pflD Escherichia coli O157:H7 str. EDL933 formate acetyltransferase 2 NP_290588.1 5019643 D 155864 CDS NP_290589.1 15804548 960180 5021906..5022784 1 NC_002655.2 pyruvate formate lyase II activase 5022784 pflC 960180 pflC Escherichia coli O157:H7 str. EDL933 pyruvate formate lyase II activase NP_290589.1 5021906 D 155864 CDS NP_290590.1 15804549 960179 5022786..5023127 1 NC_002655.2 FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog; fructose-like phosphotransferase EIIB subunit 3 5023127 frwD 960179 frwD Escherichia coli O157:H7 str. EDL933 fructose-like phosphotransferase EIIB subunit 3 NP_290590.1 5022786 D 155864 CDS NP_290591.1 15804550 960178 complement(5023114..5023965) 1 NC_002655.2 AraC family transcriptional regulator 5023965 yijO 960178 yijO Escherichia coli O157:H7 str. EDL933 AraC family transcriptional regulator NP_290591.1 5023114 R 155864 CDS NP_290592.1 15804551 960177 complement(5024180..5025913) 1 NC_002655.2 hypothetical protein 5025913 yijP 960177 yijP Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290592.1 5024180 R 155864 CDS NP_290593.1 15804552 960176 complement(5026096..5028747) 1 NC_002655.2 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 5028747 ppc 960176 ppc Escherichia coli O157:H7 str. EDL933 phosphoenolpyruvate carboxylase NP_290593.1 5026096 R 155864 CDS NP_290594.1 15804553 960175 complement(5029099..5030250) 1 NC_002655.2 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis; acetylornithine deacetylase 5030250 argE 960175 argE Escherichia coli O157:H7 str. EDL933 acetylornithine deacetylase NP_290594.1 5029099 R 155864 CDS NP_290595.1 15804554 960174 5030404..5031408 1 NC_002655.2 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 5031408 argC 960174 argC Escherichia coli O157:H7 str. EDL933 N-acetyl-gamma-glutamyl-phosphate reductase NP_290595.1 5030404 D 155864 CDS NP_290596.2 161367473 960173 5031419..5032192 1 NC_002655.2 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 5032192 argB 960173 argB Escherichia coli O157:H7 str. EDL933 acetylglutamate kinase NP_290596.2 5031419 D 155864 CDS NP_290597.1 15804556 960172 5032253..5033626 1 NC_002655.2 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 5033626 argH 960172 argH Escherichia coli O157:H7 str. EDL933 argininosuccinate lyase NP_290597.1 5032253 D 155864 CDS NP_290598.1 15804557 960171 5033893..5034810 1 NC_002655.2 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR 5034810 oxyR 960171 oxyR Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator OxyR NP_290598.1 5033893 D 155864 CDS NP_290599.2 161367472 960170 complement(5034793..5036193) 1 NC_002655.2 catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase 5036193 udhA 960170 udhA Escherichia coli O157:H7 str. EDL933 soluble pyridine nucleotide transhydrogenase NP_290599.2 5034793 R 155864 CDS NP_290600.1 15804559 960169 5036523..5037689 1 NC_002655.2 hippuricase 5037689 960169 Z5522 Escherichia coli O157:H7 str. EDL933 hippuricase NP_290600.1 5036523 D 155864 CDS NP_290601.1 15804560 960168 5037732..5039048 1 NC_002655.2 citrate permease 5039048 960168 Z5523 Escherichia coli O157:H7 str. EDL933 citrate permease NP_290601.1 5037732 D 155864 CDS NP_290602.1 15804561 960167 5039098..5039802 1 NC_002655.2 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR 5039802 yijC 960167 yijC Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional repressor FabR NP_290602.1 5039098 D 155864 CDS NP_290603.1 15804562 960166 5039802..5040161 1 NC_002655.2 hypothetical protein 5040161 yijD 960166 yijD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290603.1 5039802 D 155864 CDS NP_290604.1 15804563 960165 complement(5040201..5041301) 1 NC_002655.2 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase 5041301 trmA 960165 trmA Escherichia coli O157:H7 str. EDL933 tRNA (uracil-5-)-methyltransferase NP_290604.1 5040201 R 155864 CDS NP_290605.1 15804564 960164 5041670..5043514 1 NC_002655.2 involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space; vitamin B12/cobalamin outer membrane transporter 5043514 btuB 960164 btuB Escherichia coli O157:H7 str. EDL933 vitamin B12/cobalamin outer membrane transporter NP_290605.1 5041670 D 155864 CDS NP_290606.2 161367471 960163 5043459..5044316 1 NC_002655.2 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 5044316 murI 960163 murI Escherichia coli O157:H7 str. EDL933 glutamate racemase NP_290606.2 5043459 D 155864 CDS NP_290607.1 15804566 960158 5049837..5050865 1 NC_002655.2 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 5050865 murB 960158 murB Escherichia coli O157:H7 str. EDL933 UDP-N-acetylenolpyruvoylglucosamine reductase NP_290607.1 5049837 D 155864 CDS NP_290608.1 15804567 960157 5050862..5051827 1 NC_002655.2 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 5051827 birA 960157 birA Escherichia coli O157:H7 str. EDL933 biotin--protein ligase NP_290608.1 5050862 D 155864 CDS NP_290609.1 15804568 960156 complement(5051856..5052782) 1 NC_002655.2 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 5052782 coaA 960156 coaA Escherichia coli O157:H7 str. EDL933 pantothenate kinase NP_290609.1 5051856 R 155864 CDS NP_290610.1 15804569 960155 complement(5052976..5053131) 1 NC_002655.2 hypothetical protein 5053131 960155 Z5547 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290610.1 5052976 R 155864 CDS NP_290611.1 15804570 960150 5053707..5054891 1 NC_002655.2 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 5054891 tuf 960150 tuf Escherichia coli O157:H7 str. EDL933 elongation factor Tu NP_290611.1 5053707 D 155864 CDS NP_290612.1 15804571 960149 5055121..5055504 1 NC_002655.2 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 5055504 secE 960149 secE Escherichia coli O157:H7 str. EDL933 preprotein translocase subunit SecE NP_290612.1 5055121 D 155864 CDS NP_290613.1 15804572 960148 5055506..5056051 1 NC_002655.2 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 5056051 nusG 960148 nusG Escherichia coli O157:H7 str. EDL933 transcription antitermination protein NusG NP_290613.1 5055506 D 155864 CDS NP_290614.1 15804573 960147 5056210..5056638 1 NC_002655.2 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 5056638 rplK 960147 rplK Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L11 NP_290614.1 5056210 D 155864 CDS NP_290615.1 15804574 960146 5056642..5057346 1 NC_002655.2 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 5057346 rplA 960146 rplA Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L1 NP_290615.1 5056642 D 155864 CDS NP_290616.1 15804575 960145 5057638..5058135 1 NC_002655.2 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 5058135 rplJ 960145 rplJ Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L10 NP_290616.1 5057638 D 155864 CDS NP_290617.1 15804576 960144 5058202..5058567 1 NC_002655.2 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 5058567 rplL 960144 rplL Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L7/L12 NP_290617.1 5058202 D 155864 CDS NP_290618.1 15804577 960143 5058887..5062915 1 NC_002655.2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 5062915 rpoB 960143 rpoB Escherichia coli O157:H7 str. EDL933 DNA-directed RNA polymerase subunit beta NP_290618.1 5058887 D 155864 CDS NP_290619.1 15804578 960142 5062992..5067215 1 NC_002655.2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 5067215 rpoC 960142 rpoC Escherichia coli O157:H7 str. EDL933 DNA-directed RNA polymerase subunit beta' NP_290619.1 5062992 D 155864 CDS NP_290620.1 15804579 960141 5067428..5067871 1 NC_002655.2 heat shock protein C 5067871 htrC 960141 htrC Escherichia coli O157:H7 str. EDL933 heat shock protein C NP_290620.1 5067428 D 155864 CDS NP_290621.1 15804580 960140 complement(5068306..5069439) 1 NC_002655.2 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; thiamine biosynthesis protein ThiH 5069439 thiH 960140 thiH Escherichia coli O157:H7 str. EDL933 thiamine biosynthesis protein ThiH NP_290621.1 5068306 R 155864 CDS NP_290622.2 161367470 960139 complement(5069436..5070206) 1 NC_002655.2 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 5070206 thiG 960139 thiG Escherichia coli O157:H7 str. EDL933 thiazole synthase NP_290622.2 5069436 R 155864 CDS NP_290623.2 157267374 960138 complement(5070208..5070408) 1 NC_002655.2 with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS 5070408 thiS 960138 thiS Escherichia coli O157:H7 str. EDL933 sulfur carrier protein ThiS NP_290623.2 5070208 R 155864 CDS NP_290624.2 161367469 960137 complement(5070392..5071147) 1 NC_002655.2 catalyzes the adenylation of ThiS which is involved in the formation of 5-methyl-4-(beta-hydroxyethyl)thiazole phosphate; thiamine biosynthesis protein ThiF 5071147 thiF 960137 thiF Escherichia coli O157:H7 str. EDL933 thiamine biosynthesis protein ThiF NP_290624.2 5070392 R 155864 CDS NP_290625.1 15804584 960136 complement(5071140..5071775) 1 NC_002655.2 catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate; thiamine-phosphate pyrophosphorylase 5071775 thiE 960136 thiE Escherichia coli O157:H7 str. EDL933 thiamine-phosphate pyrophosphorylase NP_290625.1 5071140 R 155864 CDS NP_290626.1 15804585 960135 complement(5071775..5073670) 1 NC_002655.2 required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 5073670 thiC 960135 thiC Escherichia coli O157:H7 str. EDL933 thiamine biosynthesis protein ThiC NP_290626.1 5071775 R 155864 CDS NP_290627.1 15804586 960134 complement(5073903..5074379) 1 NC_002655.2 binds specifically to the major sigma factor sigma 70; active in stationary phase; anti-RNA polymerase sigma 70 factor 5074379 yjaE 960134 yjaE Escherichia coli O157:H7 str. EDL933 anti-RNA polymerase sigma 70 factor NP_290627.1 5073903 R 155864 CDS NP_290628.1 15804587 960133 5074474..5075247 1 NC_002655.2 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 5075247 nudC 960133 nudC Escherichia coli O157:H7 str. EDL933 NADH pyrophosphatase NP_290628.1 5074474 D 155864 CDS NP_290629.1 15804588 960132 5075287..5076351 1 NC_002655.2 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 5076351 hemE 960132 hemE Escherichia coli O157:H7 str. EDL933 uroporphyrinogen decarboxylase NP_290629.1 5075287 D 155864 CDS NP_290630.1 15804589 960131 5076361..5077032 1 NC_002655.2 Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures; endonuclease V 5077032 nfi 960131 nfi Escherichia coli O157:H7 str. EDL933 endonuclease V NP_290630.1 5076361 D 155864 CDS NP_290631.1 15804590 960130 5077075..5077665 1 NC_002655.2 hypothetical protein 5077665 yjaG 960130 yjaG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290631.1 5077075 D 155864 CDS NP_290632.1 15804591 960129 5077852..5078124 1 NC_002655.2 histone-like DNA-binding protein; transcriptional regulator HU subunit alpha 5078124 hupA 960129 hupA Escherichia coli O157:H7 str. EDL933 transcriptional regulator HU subunit alpha NP_290632.1 5077852 D 155864 CDS NP_290633.1 15804592 960128 5078137..5078832 1 NC_002655.2 hypothetical protein 5078832 yjaH 960128 yjaH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290633.1 5078137 D 155864 CDS NP_290634.2 161367468 960127 complement(5078834..5079259) 1 NC_002655.2 zinc resistance protein 5079259 zraP 960127 zraP Escherichia coli O157:H7 str. EDL933 zinc resistance protein NP_290634.2 5078834 R 155864 CDS NP_290635.1 15804594 960126 5079497..5080873 1 NC_002655.2 sensor protein ZraS 5080873 hydH 960126 hydH Escherichia coli O157:H7 str. EDL933 sensor protein ZraS NP_290635.1 5079497 D 155864 CDS NP_290636.1 15804595 960125 5080870..5082195 1 NC_002655.2 DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; transcriptional regulatory protein ZraR 5082195 hydG 960125 hydG Escherichia coli O157:H7 str. EDL933 transcriptional regulatory protein ZraR NP_290636.1 5080870 D 155864 CDS NP_290637.1 15804596 960124 complement(5082192..5083481) 1 NC_002655.2 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 5083481 purD 960124 purD Escherichia coli O157:H7 str. EDL933 phosphoribosylamine--glycine ligase NP_290637.1 5082192 R 155864 CDS NP_290638.1 15804597 960123 complement(5083493..5085082) 1 NC_002655.2 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 5085082 purH 960123 purH Escherichia coli O157:H7 str. EDL933 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase NP_290638.1 5083493 R 155864 CDS NP_290639.1 15804598 960118 complement(5090824..5091267) 1 NC_002655.2 hypothetical protein 5091267 yjaB 960118 yjaB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290639.1 5090824 R 155864 CDS NP_290640.1 15804599 960117 5091424..5092353 1 NC_002655.2 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 5092353 metA 960117 metA Escherichia coli O157:H7 str. EDL933 homoserine O-succinyltransferase NP_290640.1 5091424 D 155864 CDS NP_290641.1 15804600 960116 5092622..5094223 1 NC_002655.2 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle; malate synthase 5094223 aceB 960116 aceB Escherichia coli O157:H7 str. EDL933 malate synthase NP_290641.1 5092622 D 155864 CDS NP_290642.1 15804601 960115 5094238..5095557 1 NC_002655.2 Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates; isocitrate lyase 5095557 aceA 960115 aceA Escherichia coli O157:H7 str. EDL933 isocitrate lyase NP_290642.1 5094238 D 155864 CDS NP_290643.1 15804602 960114 5095741..5097477 1 NC_002655.2 catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol; bifunctional isocitrate dehydrogenase kinase/phosphatase 5097477 aceK 960114 aceK Escherichia coli O157:H7 str. EDL933 bifunctional isocitrate dehydrogenase kinase/phosphatase NP_290643.1 5095741 D 155864 CDS NP_290644.1 15804603 960113 complement(5097446..5099632) 1 NC_002655.2 regulator of acetyl CoA synthetase 5099632 arp 960113 arp Escherichia coli O157:H7 str. EDL933 regulator of acetyl CoA synthetase NP_290644.1 5097446 R 155864 CDS NP_290645.2 161367467 960112 complement(5099950..5100774) 1 NC_002655.2 regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase; IclR family transcriptional regulator 5100774 iclR 960112 iclR Escherichia coli O157:H7 str. EDL933 IclR family transcriptional regulator NP_290645.2 5099950 R 155864 CDS NP_290646.1 15804605 960111 5100974..5104657 1 NC_002655.2 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase 5104657 metH 960111 metH Escherichia coli O157:H7 str. EDL933 B12-dependent methionine synthase NP_290646.1 5100974 D 155864 CDS NP_290647.1 15804606 960110 5104877..5106508 1 NC_002655.2 alpha helix protein 5106508 yjbB 960110 yjbB Escherichia coli O157:H7 str. EDL933 alpha helix protein NP_290647.1 5104877 D 155864 CDS NP_290648.1 15804607 960109 complement(5106599..5107288) 1 NC_002655.2 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family; peptidase E 5107288 pepE 960109 pepE Escherichia coli O157:H7 str. EDL933 peptidase E NP_290648.1 5106599 R 155864 CDS NP_290649.1 15804608 960108 complement(5107671..5108912) 1 NC_002655.2 L-sorbose-1-P-reductase 5108912 960108 Z5613 Escherichia coli O157:H7 str. EDL933 L-sorbose-1-P-reductase NP_290649.1 5107671 R 155864 CDS NP_290650.1 15804609 960107 complement(5108952..5109776) 1 NC_002655.2 sorbose PTS component 5109776 960107 Z5614 Escherichia coli O157:H7 str. EDL933 sorbose PTS component NP_290650.1 5108952 R 155864 CDS NP_290651.1 15804610 960106 complement(5109787..5110584) 1 NC_002655.2 sorbose PTS component 5110584 960106 Z5615 Escherichia coli O157:H7 str. EDL933 sorbose PTS component NP_290651.1 5109787 R 155864 CDS NP_290652.1 15804611 960105 complement(5110650..5111144) 1 NC_002655.2 sorbose PTS component 5111144 960105 Z5616 Escherichia coli O157:H7 str. EDL933 sorbose PTS component NP_290652.1 5110650 R 155864 CDS NP_290653.1 15804612 960104 complement(5111144..5111551) 1 NC_002655.2 sorbose PTS component 5111551 960104 Z5617 Escherichia coli O157:H7 str. EDL933 sorbose PTS component NP_290653.1 5111144 R 155864 CDS NP_290654.1 15804613 960103 complement(5111561..5112367) 1 NC_002655.2 Converts D-sorbitol-dphosphate to D-fructose-6-phosphate; sorbitol-6-phosphate 2-dehydrogenase 5112367 960103 Z5618 Escherichia coli O157:H7 str. EDL933 sorbitol-6-phosphate 2-dehydrogenase NP_290654.1 5111561 R 155864 CDS NP_290655.1 15804614 960102 complement(5112437..5113405) 1 NC_002655.2 transcriptional regulator of sorbose uptake and utilization genes 5113405 960102 Z5619 Escherichia coli O157:H7 str. EDL933 transcriptional regulator of sorbose uptake and utilization genes NP_290655.1 5112437 R 155864 CDS NP_290656.1 15804615 960101 5113732..5114604 1 NC_002655.2 catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA; 23S rRNA pseudouridine synthase F 5114604 yjbC 960101 yjbC Escherichia coli O157:H7 str. EDL933 23S rRNA pseudouridine synthase F NP_290656.1 5113732 D 155864 CDS NP_290657.1 15804616 960100 complement(5114605..5114877) 1 NC_002655.2 hypothetical protein 5114877 yjbD 960100 yjbD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290657.1 5114605 R 155864 CDS NP_290658.1 15804617 960099 complement(5115130..5116479) 1 NC_002655.2 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive; aspartate kinase 5116479 lysC 960099 lysC Escherichia coli O157:H7 str. EDL933 aspartate kinase NP_290658.1 5115130 R 155864 CDS NP_290659.1 15804618 960098 5117004..5118653 1 NC_002655.2 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 5118653 pgi 960098 pgi Escherichia coli O157:H7 str. EDL933 glucose-6-phosphate isomerase NP_290659.1 5117004 D 155864 CDS NP_290660.1 15804619 960097 5119166..5119408 1 NC_002655.2 hypothetical protein 5119408 yjbE 960097 yjbE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290660.1 5119166 D 155864 CDS NP_290661.1 15804620 960096 5119492..5120160 1 NC_002655.2 hypothetical protein 5120160 yjbF 960096 yjbF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290661.1 5119492 D 155864 CDS NP_290662.1 15804621 960095 5120157..5120894 1 NC_002655.2 hypothetical protein 5120894 yjbG 960095 yjbG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290662.1 5120157 D 155864 CDS NP_290663.1 15804622 960094 5120894..5122990 1 NC_002655.2 hypothetical protein 5122990 yjbH 960094 yjbH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290663.1 5120894 D 155864 CDS NP_290664.1 15804623 960093 5123585..5123995 1 NC_002655.2 phosphate-starvation-inducible protein PsiE 5123995 yjbA 960093 yjbA Escherichia coli O157:H7 str. EDL933 phosphate-starvation-inducible protein PsiE NP_290664.1 5123585 D 155864 CDS NP_290665.1 15804624 960092 complement(5124039..5125514) 1 NC_002655.2 xylose/proton symporter; member of the major facilitator superfamily (MFS) of transporter; D-xylose transporter XylE 5125514 xylE 960092 xylE Escherichia coli O157:H7 str. EDL933 D-xylose transporter XylE NP_290665.1 5124039 R 155864 CDS NP_290666.1 15804625 960091 complement(5125886..5126776) 1 NC_002655.2 with MalKFE is involved in the transport of maltose into the cell; maltose ABC transporter permease 5126776 malG 960091 malG Escherichia coli O157:H7 str. EDL933 maltose ABC transporter permease NP_290666.1 5125886 R 155864 CDS NP_290667.1 15804626 960090 complement(5126791..5128335) 1 NC_002655.2 with MalKGE is involved in maltose transport into the cell; maltose transporter membrane protein 5128335 malF 960090 malF Escherichia coli O157:H7 str. EDL933 maltose transporter membrane protein NP_290667.1 5126791 R 155864 CDS NP_290668.1 15804627 960089 complement(5128489..5129679) 1 NC_002655.2 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis; maltose ABC transporter substrate-binding protein 5129679 malE 960089 malE Escherichia coli O157:H7 str. EDL933 maltose ABC transporter substrate-binding protein NP_290668.1 5128489 R 155864 CDS NP_290669.1 15804628 960088 5130044..5131159 1 NC_002655.2 with malEFG is involved in import of maltose/maltodextrin; maltose ABC transporter ATP-binding protein 5131159 malK 960088 malK Escherichia coli O157:H7 str. EDL933 maltose ABC transporter ATP-binding protein NP_290669.1 5130044 D 155864 CDS NP_290670.1 15804629 960087 5131231..5132571 1 NC_002655.2 porin involved in the transport of maltose and maltodextrins; maltoporin 5132571 lamB 960087 lamB Escherichia coli O157:H7 str. EDL933 maltoporin NP_290670.1 5131231 D 155864 CDS NP_290671.1 15804630 960086 5132722..5133642 1 NC_002655.2 maltose regulon periplasmic protein 5133642 malM 960086 malM Escherichia coli O157:H7 str. EDL933 maltose regulon periplasmic protein NP_290671.1 5132722 D 155864 CDS NP_290672.1 15804631 960085 5133871..5135451 1 NC_002655.2 in E. coli, some yjbl mutations have been reported as suppressors of dnaG mutations; hypothetical protein 5135451 yjbI 960085 yjbI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290672.1 5133871 D 155864 CDS NP_290673.2 161367466 960084 5135674..5136171 1 NC_002655.2 catalyzes the formation of 4-hydroxybenzoate from chorismate; chorismate pyruvate lyase 5136171 ubiC 960084 ubiC Escherichia coli O157:H7 str. EDL933 chorismate pyruvate lyase NP_290673.2 5135674 D 155864 CDS NP_290674.1 15804633 960083 5136184..5137056 1 NC_002655.2 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway; 4-hydroxybenzoate octaprenyltransferase 5137056 ubiA 960083 ubiA Escherichia coli O157:H7 str. EDL933 4-hydroxybenzoate octaprenyltransferase NP_290674.1 5136184 D 155864 CDS NP_290675.2 161367465 960082 complement(5137211..5139634) 1 NC_002655.2 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 5139634 plsB 960082 plsB Escherichia coli O157:H7 str. EDL933 glycerol-3-phosphate acyltransferase NP_290675.2 5137211 R 155864 CDS NP_290676.1 15804635 960081 5139805..5140173 1 NC_002655.2 diacylglycerol kinase 5140173 dgkA 960081 dgkA Escherichia coli O157:H7 str. EDL933 diacylglycerol kinase NP_290676.1 5139805 D 155864 CDS NP_290677.1 15804636 960080 5140283..5140891 1 NC_002655.2 Represses a number of genes involved in the response to DNA damage; LexA repressor 5140891 lexA 960080 lexA Escherichia coli O157:H7 str. EDL933 LexA repressor NP_290677.1 5140283 D 155864 CDS NP_290678.2 161367464 960079 5140964..5142289 1 NC_002655.2 DNA-damage-inducible SOS response protein 5142289 dinF 960079 dinF Escherichia coli O157:H7 str. EDL933 DNA-damage-inducible SOS response protein NP_290678.2 5140964 D 155864 CDS NP_290679.1 15804638 960078 5142405..5142614 1 NC_002655.2 unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential; stress-response protein 5142614 yjbJ 960078 yjbJ Escherichia coli O157:H7 str. EDL933 stress-response protein NP_290679.1 5142405 D 155864 CDS NP_290680.2 161367463 960077 complement(5142656..5143171) 1 NC_002655.2 Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB; zinc uptake transcriptional repressor 5143171 yjbK 960077 yjbK Escherichia coli O157:H7 str. EDL933 zinc uptake transcriptional repressor NP_290680.2 5142656 R 155864 CDS NP_290681.1 15804640 960076 5143490..5144446 1 NC_002655.2 hypothetical protein 5144446 960076 Z5646 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290681.1 5143490 D 155864 CDS NP_290682.1 15804641 960075 5144808..5145845 1 NC_002655.2 tRNA-dihydrouridine synthase A 5145845 yjbN 960075 yjbN Escherichia coli O157:H7 str. EDL933 tRNA-dihydrouridine synthase A NP_290682.1 5144808 D 155864 CDS NP_290683.2 161367462 960074 5145979..5146221 1 NC_002655.2 coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia; phage shock protein G 5146221 pspG 960074 pspG Escherichia coli O157:H7 str. EDL933 phage shock protein G NP_290683.2 5145979 D 155864 CDS NP_290684.1 15804643 960073 complement(5146387..5147370) 1 NC_002655.2 quinone oxidoreductase 5147370 qor 960073 qor Escherichia coli O157:H7 str. EDL933 quinone oxidoreductase NP_290684.1 5146387 R 155864 CDS NP_290685.1 15804644 960072 5147453..5148868 1 NC_002655.2 unwinds double stranded DNA; replicative DNA helicase 5148868 dnaB 960072 dnaB Escherichia coli O157:H7 str. EDL933 replicative DNA helicase NP_290685.1 5147453 D 155864 CDS NP_290686.1 15804645 960071 5148921..5150000 1 NC_002655.2 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 5150000 alr 960071 alr Escherichia coli O157:H7 str. EDL933 alanine racemase NP_290686.1 5148921 D 155864 CDS NP_290687.1 15804646 960070 5150253..5151446 1 NC_002655.2 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 5151446 tyrB 960070 tyrB Escherichia coli O157:H7 str. EDL933 aromatic amino acid aminotransferase NP_290687.1 5150253 D 155864 CDS NP_290688.1 15804647 960069 5152545..5153258 1 NC_002655.2 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase 5153258 aphA 960069 aphA Escherichia coli O157:H7 str. EDL933 acid phosphatase/phosphotransferase NP_290688.1 5152545 D 155864 CDS NP_290689.1 15804648 960068 5153369..5153785 1 NC_002655.2 hypothetical protein 5153785 yjbQ 960068 yjbQ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290689.1 5153369 D 155864 CDS NP_290690.1 15804649 960067 5153789..5154145 1 NC_002655.2 hypothetical protein 5154145 yjbR 960067 yjbR Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290690.1 5153789 D 155864 CDS NP_290691.1 15804650 960066 complement(5154180..5157002) 1 NC_002655.2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 5157002 uvrA 960066 uvrA Escherichia coli O157:H7 str. EDL933 excinuclease ABC subunit A NP_290691.1 5154180 R 155864 CDS NP_290692.1 15804651 960065 5157257..5157793 1 NC_002655.2 binds to single stranded DNA and PriA helcase facilitate replication restart; single-stranded DNA-binding protein 5157793 ssb 960065 ssb Escherichia coli O157:H7 str. EDL933 single-stranded DNA-binding protein NP_290692.1 5157257 D 155864 CDS NP_290693.1 15804652 960064 complement(5157892..5158242) 1 NC_002655.2 hypothetical protein 5158242 yjcB 960064 yjcB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290693.1 5157892 R 155864 CDS NP_290694.1 15804653 960063 5158602..5160188 1 NC_002655.2 hypothetical protein 5160188 yjcC 960063 yjcC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290694.1 5158602 D 155864 CDS NP_290695.1 15804654 960062 complement(5160191..5160514) 1 NC_002655.2 regulates genes involved in response to oxidative stress; DNA-binding transcriptional regulator SoxS 5160514 soxS 960062 soxS Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator SoxS NP_290695.1 5160191 R 155864 CDS NP_290696.1 15804655 960061 5160600..5161064 1 NC_002655.2 redox-sensitive transcriptional activator SoxR 5161064 soxR 960061 soxR Escherichia coli O157:H7 str. EDL933 redox-sensitive transcriptional activator SoxR NP_290696.1 5160600 D 155864 CDS NP_290697.1 15804656 960060 5161610..5162959 1 NC_002655.2 hypothetical protein 5162959 yjcD 960060 yjcD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290697.1 5161610 D 155864 CDS NP_290698.1 15804657 960059 5163110..5164759 1 NC_002655.2 hypothetical protein 5164759 yjcE 960059 yjcE Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290698.1 5163110 D 155864 CDS NP_290699.1 15804658 960058 complement(5164913..5166205) 1 NC_002655.2 hypothetical protein 5166205 yjcF 960058 yjcF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290699.1 5164913 R 155864 CDS NP_290700.1 15804659 960057 complement(5166386..5168035) 1 NC_002655.2 member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake; acetate permease 5168035 actP 960057 actP Escherichia coli O157:H7 str. EDL933 acetate permease NP_290700.1 5166386 R 155864 CDS NP_290701.1 15804660 960056 complement(5168032..5168346) 1 NC_002655.2 hypothetical protein 5168346 yjcH 960056 yjcH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290701.1 5168032 R 155864 CDS NP_290702.1 15804661 960055 complement(5168547..5170505) 1 NC_002655.2 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase 5170505 acs 960055 acs Escherichia coli O157:H7 str. EDL933 acetyl-CoA synthetase NP_290702.1 5168547 R 155864 CDS NP_290703.1 15804662 960054 5170898..5172334 1 NC_002655.2 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 5172334 nrfA 960054 nrfA Escherichia coli O157:H7 str. EDL933 cytochrome c552 NP_290703.1 5170898 D 155864 CDS NP_290704.1 15804663 960053 5172373..5172945 1 NC_002655.2 part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit 5172945 nrfB 960053 nrfB Escherichia coli O157:H7 str. EDL933 cytochrome c nitrite reductase pentaheme subunit NP_290704.1 5172373 D 155864 CDS NP_290705.1 15804664 960052 5172942..5173613 1 NC_002655.2 formate-dependent nitrite reductase; Fe-S centers 5173613 nrfC 960052 nrfC Escherichia coli O157:H7 str. EDL933 formate-dependent nitrite reductase; Fe-S centers NP_290705.1 5172942 D 155864 CDS NP_290706.1 15804665 960051 5173610..5174566 1 NC_002655.2 formate-dependent nitrate reductase complex; transmembrane protein 5174566 nrfD 960051 nrfD Escherichia coli O157:H7 str. EDL933 formate-dependent nitrate reductase complex; transmembrane protein NP_290706.1 5173610 D 155864 CDS NP_290707.1 15804666 960050 5174646..5176304 1 NC_002655.2 with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552; heme lyase subunit NrfE 5176304 nrfE 960050 nrfE Escherichia coli O157:H7 str. EDL933 heme lyase subunit NrfE NP_290707.1 5174646 D 155864 CDS NP_290708.1 15804667 960049 5176297..5176680 1 NC_002655.2 formate-dependent nitrite reductase complex subunit NrfF 5176680 nrfF 960049 nrfF Escherichia coli O157:H7 str. EDL933 formate-dependent nitrite reductase complex subunit NrfF NP_290708.1 5176297 D 155864 CDS NP_290709.1 15804668 960048 5176677..5177273 1 NC_002655.2 formate-dependent nitrite reductase complex subunit NrfG 5177273 nrfG 960048 nrfG Escherichia coli O157:H7 str. EDL933 formate-dependent nitrite reductase complex subunit NrfG NP_290709.1 5176677 D 155864 CDS NP_290710.1 15804669 960047 5177615..5178928 1 NC_002655.2 carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system; glutamate/aspartate:proton symporter 5178928 gltP 960047 gltP Escherichia coli O157:H7 str. EDL933 glutamate/aspartate:proton symporter NP_290710.1 5177615 D 155864 CDS NP_290711.1 15804670 960046 complement(5179106..5179795) 1 NC_002655.2 hypothetical protein 5179795 yjcO 960046 yjcO Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290711.1 5179106 R 155864 CDS NP_290712.1 15804671 960045 complement(5179889..5182036) 1 NC_002655.2 formate dehydrogenase 5182036 fdhF 960045 fdhF Escherichia coli O157:H7 str. EDL933 formate dehydrogenase NP_290712.1 5179889 R 155864 CDS NP_290713.1 15804672 960044 complement(5182234..5183700) 1 NC_002655.2 part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family; outer membrane efflux protein MdtP 5183700 yjcP 960044 yjcP Escherichia coli O157:H7 str. EDL933 outer membrane efflux protein MdtP NP_290713.1 5182234 R 155864 CDS NP_290714.2 161367461 960043 complement(5183697..5185748) 1 NC_002655.2 possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug efflux system protein MdtO 5185748 yjcQ 960043 yjcQ Escherichia coli O157:H7 str. EDL933 multidrug efflux system protein MdtO NP_290714.2 5183697 R 155864 CDS NP_290715.1 15804674 960042 complement(5185748..5186779) 1 NC_002655.2 with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance protein MdtN 5186779 yjcR 960042 yjcR Escherichia coli O157:H7 str. EDL933 multidrug resistance protein MdtN NP_290715.1 5185748 R 155864 CDS NP_290716.1 15804675 960041 complement(5187282..5189279) 1 NC_002655.2 hypothetical protein 5189279 yjcS 960041 yjcS Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290716.1 5187282 R 155864 CDS NP_290717.1 15804676 960040 5189540..5190265 1 NC_002655.2 transcriptional regulator 5190265 960040 Z5684 Escherichia coli O157:H7 str. EDL933 transcriptional regulator NP_290717.1 5189540 D 155864 CDS NP_290718.1 15804677 960039 complement(5190262..5191263) 1 NC_002655.2 kinase 5191263 960039 Z5686 Escherichia coli O157:H7 str. EDL933 kinase NP_290718.1 5190262 R 155864 CDS NP_290719.1 15804678 960038 complement(5191260..5192120) 1 NC_002655.2 hypothetical protein 5192120 960038 Z5687 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290719.1 5191260 R 155864 CDS NP_290720.1 15804679 960037 complement(5192135..5192818) 1 NC_002655.2 No significant matches; hypothetical protein 5192818 960037 Z5688 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290720.1 5192135 R 155864 CDS NP_290721.1 15804680 960036 complement(5192873..5193814) 1 NC_002655.2 ABC transporter substrate-binding protein 5193814 960036 Z5689 Escherichia coli O157:H7 str. EDL933 ABC transporter substrate-binding protein NP_290721.1 5192873 R 155864 CDS NP_290722.1 15804681 960035 complement(5193833..5194807) 1 NC_002655.2 permease of ribose ABC transport system 5194807 960035 Z5690 Escherichia coli O157:H7 str. EDL933 permease of ribose ABC transport system NP_290722.1 5193833 R 155864 CDS NP_290723.1 15804682 960034 complement(5194804..5196357) 1 NC_002655.2 ribose ABC transporter ATP-binding protein 5196357 960034 Z5691 Escherichia coli O157:H7 str. EDL933 ribose ABC transporter ATP-binding protein NP_290723.1 5194804 R 155864 CDS NP_290724.1 15804683 960033 5196438..5198708 1 NC_002655.2 histidine kinase 5198708 960033 Z5692 Escherichia coli O157:H7 str. EDL933 histidine kinase NP_290724.1 5196438 D 155864 CDS NP_290725.1 15804684 960032 5198777..5199106 1 NC_002655.2 hypothetical protein 5199106 960032 Z5694 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290725.1 5198777 D 155864 CDS NP_290726.1 15804685 960031 complement(5199183..5199941) 1 NC_002655.2 required for the use of phosphonates and phosphite as phosphorus sources; carbon-phosphorus lyase complex accessory protein 5199941 phnP 960031 phnP Escherichia coli O157:H7 str. EDL933 carbon-phosphorus lyase complex accessory protein NP_290726.1 5199183 R 155864 CDS NP_290727.1 15804686 960030 complement(5199943..5200272) 1 NC_002655.2 PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role; aminoalkylphosphonic acid N-acetyltransferase 5200272 phnO 960030 phnO Escherichia coli O157:H7 str. EDL933 aminoalkylphosphonic acid N-acetyltransferase NP_290727.1 5199943 R 155864 CDS NP_290728.1 15804687 960029 complement(5200365..5200922) 1 NC_002655.2 ribose 1,5-bisphosphokinase 5200922 phnN 960029 phnN Escherichia coli O157:H7 str. EDL933 ribose 1,5-bisphosphokinase NP_290728.1 5200365 R 155864 CDS NP_290729.1 15804688 960028 complement(5200922..5202058) 1 NC_002655.2 phosphonate metabolism protein 5202058 phnM 960028 phnM Escherichia coli O157:H7 str. EDL933 phosphonate metabolism protein NP_290729.1 5200922 R 155864 CDS NP_290730.1 15804689 960027 complement(5202055..5202735) 1 NC_002655.2 phosphonate ABC transporter ATP-binding protein 5202735 phnL 960027 phnL Escherichia coli O157:H7 str. EDL933 phosphonate ABC transporter ATP-binding protein NP_290730.1 5202055 R 155864 CDS NP_290731.1 15804690 960026 complement(5202846..5203604) 1 NC_002655.2 phosphonate C-P lyase system protein PhnK 5203604 phnK 960026 phnK Escherichia coli O157:H7 str. EDL933 phosphonate C-P lyase system protein PhnK NP_290731.1 5202846 R 155864 CDS NP_290732.1 15804691 960025 complement(5203601..5204446) 1 NC_002655.2 phosphonate metabolism protein 5204446 phnJ 960025 phnJ Escherichia coli O157:H7 str. EDL933 phosphonate metabolism protein NP_290732.1 5203601 R 155864 CDS NP_290733.1 15804692 960024 complement(5204439..5205503) 1 NC_002655.2 phosphonate metabolism protein 5205503 phnI 960024 phnI Escherichia coli O157:H7 str. EDL933 phosphonate metabolism protein NP_290733.1 5204439 R 155864 CDS NP_290734.1 15804693 960023 complement(5205503..5206087) 1 NC_002655.2 carbon-phosphorus lyase complex subunit 5206087 phnH 960023 phnH Escherichia coli O157:H7 str. EDL933 carbon-phosphorus lyase complex subunit NP_290734.1 5205503 R 155864 CDS NP_290735.1 15804694 960022 complement(5206084..5206536) 1 NC_002655.2 phosphonate metabolism protein 5206536 phnG 960022 phnG Escherichia coli O157:H7 str. EDL933 phosphonate metabolism protein NP_290735.1 5206084 R 155864 CDS NP_290736.1 15804695 960021 complement(5206537..5207262) 1 NC_002655.2 may be involved in phosphonate uptake and biodegradation; phosphonate metabolism transcriptional regulator PhnF 5207262 phnF 960021 phnF Escherichia coli O157:H7 str. EDL933 phosphonate metabolism transcriptional regulator PhnF NP_290736.1 5206537 R 155864 CDS NP_290737.1 15804696 960020 complement(5207283..5208113) 1 NC_002655.2 membrane channel protein component of Pn transporter 5208113 phnE 960020 phnE Escherichia coli O157:H7 str. EDL933 membrane channel protein component of Pn transporter NP_290737.1 5207283 R 155864 CDS NP_290738.1 15804697 960019 complement(5208168..5209184) 1 NC_002655.2 periplasmic binding protein component of Pn transporter 5209184 phnD 960019 phnD Escherichia coli O157:H7 str. EDL933 periplasmic binding protein component of Pn transporter NP_290738.1 5208168 R 155864 CDS NP_290739.1 15804698 960018 complement(5209209..5209997) 1 NC_002655.2 phosphonate/organophosphate ester transporter subunit 5209997 phnC 960018 phnC Escherichia coli O157:H7 str. EDL933 phosphonate/organophosphate ester transporter subunit NP_290739.1 5209209 R 155864 CDS NP_290740.1 15804699 960017 complement(5210130..5210573) 1 NC_002655.2 hypothetical protein 5210573 phnB 960017 phnB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290740.1 5210130 R 155864 CDS NP_290741.1 15804700 960016 complement(5210832..5211167) 1 NC_002655.2 hypothetical protein 5211167 phnA 960016 phnA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290741.1 5210832 R 155864 CDS NP_290742.1 15804701 960015 5211569..5213797 1 NC_002655.2 hypothetical protein 5213797 yjdA 960015 yjdA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290742.1 5211569 D 155864 CDS NP_290743.1 15804702 960014 5213827..5214672 1 NC_002655.2 hypothetical protein 5214672 yjcZ 960014 yjcZ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290743.1 5213827 D 155864 CDS NP_290744.1 15804703 960013 5214936..5216438 1 NC_002655.2 proline/glycine betaine transporter 5216438 proP 960013 proP Escherichia coli O157:H7 str. EDL933 proline/glycine betaine transporter NP_290744.1 5214936 D 155864 CDS NP_290745.1 15804704 960012 complement(5216615..5217706) 1 NC_002655.2 sensor protein BasS/PmrB 5217706 basS 960012 basS Escherichia coli O157:H7 str. EDL933 sensor protein BasS/PmrB NP_290745.1 5216615 R 155864 CDS NP_290746.1 15804705 960011 complement(5217716..5218384) 1 NC_002655.2 response regulator in two-component regulatory system with BasS; DNA-binding transcriptional regulator BasR 5218384 basR 960011 basR Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator BasR NP_290746.1 5217716 R 155864 CDS NP_290747.1 15804706 960010 complement(5218381..5220054) 1 NC_002655.2 with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division; cell division protein 5220054 yjdB 960010 yjdB Escherichia coli O157:H7 str. EDL933 cell division protein NP_290747.1 5218381 R 155864 CDS NP_290748.1 15804707 960009 complement(5220128..5221465) 1 NC_002655.2 arginine:agmatin antiporter 5221465 yjdE 960009 yjdE Escherichia coli O157:H7 str. EDL933 arginine:agmatin antiporter NP_290748.1 5220128 R 155864 CDS NP_290749.1 15804708 960008 complement(5221602..5222363) 1 NC_002655.2 AraC family transcriptional regulator 5222363 adiY 960008 adiY Escherichia coli O157:H7 str. EDL933 AraC family transcriptional regulator NP_290749.1 5221602 R 155864 CDS NP_290750.1 15804709 960007 complement(5222688..5224958) 1 NC_002655.2 biodegradative arginine decarboxylase 5224958 adiA 960007 adiA Escherichia coli O157:H7 str. EDL933 biodegradative arginine decarboxylase NP_290750.1 5222688 R 155864 CDS NP_290751.1 15804710 960006 complement(5225154..5226062) 1 NC_002655.2 DNA-binding transcriptional regulator MelR 5226062 melR 960006 melR Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator MelR NP_290751.1 5225154 R 155864 CDS NP_290752.1 15804711 960005 5226345..5227700 1 NC_002655.2 alpha-galactosidase 5227700 melA 960005 melA Escherichia coli O157:H7 str. EDL933 alpha-galactosidase NP_290752.1 5226345 D 155864 CDS NP_290753.1 15804712 960004 5227815..5229224 1 NC_002655.2 melibiose:sodium symporter 5229224 melB 960004 melB Escherichia coli O157:H7 str. EDL933 melibiose:sodium symporter NP_290753.1 5227815 D 155864 CDS NP_290754.1 15804713 960003 complement(5229363..5229992) 1 NC_002655.2 hypothetical protein 5229992 yjdF 960003 yjdF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290754.1 5229363 R 155864 CDS NP_290755.1 15804714 960002 complement(5230115..5231761) 1 NC_002655.2 fumarase B 5231761 fumB 960002 fumB Escherichia coli O157:H7 str. EDL933 fumarase B NP_290755.1 5230115 R 155864 CDS NP_290756.1 15804715 960001 complement(5231839..5233179) 1 NC_002655.2 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter 5233179 dcuB 960001 dcuB Escherichia coli O157:H7 str. EDL933 anaerobic C4-dicarboxylate transporter NP_290756.1 5231839 R 155864 CDS NP_290757.1 15804716 960000 complement(5233750..5234469) 1 NC_002655.2 response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration; DNA-binding transcriptional activator DcuR 5234469 yjdG 960000 yjdG Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional activator DcuR NP_290757.1 5233750 R 155864 CDS NP_290758.1 15804717 959999 complement(5234466..5236097) 1 NC_002655.2 C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration; sensory histidine kinase DcuS 5236097 yjdH 959999 yjdH Escherichia coli O157:H7 str. EDL933 sensory histidine kinase DcuS NP_290758.1 5234466 R 155864 CDS NP_290759.1 15804718 959998 5236278..5236508 1 NC_002655.2 hypothetical protein 5236508 yjdI 959998 yjdI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290759.1 5236278 D 155864 CDS NP_290760.1 15804719 959997 5236520..5236792 1 NC_002655.2 hypothetical protein 5236792 yjdJ 959997 yjdJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290760.1 5236520 D 155864 CDS NP_290761.1 15804720 959996 5237019..5237315 1 NC_002655.2 hypothetical protein 5237315 yjdK 959996 yjdK Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290761.1 5237019 D 155864 CDS NP_290762.1 15804721 959995 5237343..5237516 1 NC_002655.2 hypothetical protein 5237516 959995 Z5731 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290762.1 5237343 D 155864 CDS NP_290763.1 15804722 959994 complement(5237635..5239152) 1 NC_002655.2 class II; inducible; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; induced by high temperature, anaerobiosis, and low pH; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 5239152 lysS 959994 lysS Escherichia coli O157:H7 str. EDL933 lysyl-tRNA synthetase NP_290763.1 5237635 R 155864 CDS NP_290764.1 15804723 959993 complement(5239389..5240846) 1 NC_002655.2 peptide transporter 5240846 yjdL 959993 yjdL Escherichia coli O157:H7 str. EDL933 peptide transporter NP_290764.1 5239389 R 155864 CDS NP_290765.1 15804724 959992 complement(5240905..5243052) 1 NC_002655.2 lysine decarboxylase 1 5243052 cadA 959992 cadA Escherichia coli O157:H7 str. EDL933 lysine decarboxylase 1 NP_290765.1 5240905 R 155864 CDS NP_290766.1 15804725 959991 complement(5243132..5244466) 1 NC_002655.2 antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein; lysine/cadaverine antiporter 5244466 cadB 959991 cadB Escherichia coli O157:H7 str. EDL933 lysine/cadaverine antiporter NP_290766.1 5243132 R 155864 CDS NP_290767.1 15804726 959990 complement(5244832..5246370) 1 NC_002655.2 regulates the cadBA operon; DNA-binding transcriptional activator CadC 5246370 cadC 959990 cadC Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional activator CadC NP_290767.1 5244832 R 155864 CDS NP_290768.1 15804727 959988 complement(5247169..5247768) 1 NC_002655.2 transcriptional regulator 5247768 yjdC 959988 yjdC Escherichia coli O157:H7 str. EDL933 transcriptional regulator NP_290768.1 5247169 R 155864 CDS NP_290769.1 15804728 959987 complement(5247781..5249478) 1 NC_002655.2 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein 5249478 dipZ 959987 dipZ Escherichia coli O157:H7 str. EDL933 thiol:disulfide interchange protein NP_290769.1 5247781 R 155864 CDS NP_290770.1 15804729 959986 complement(5249454..5249792) 1 NC_002655.2 copper binding protein required for copper tolerance; involved in resistance toward heavy metals; divalent-cation tolerance protein CutA 5249792 cutA 959986 cutA Escherichia coli O157:H7 str. EDL933 divalent-cation tolerance protein CutA NP_290770.1 5249454 R 155864 CDS NP_290771.1 15804730 959985 complement(5249908..5251209) 1 NC_002655.2 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter 5251209 dcuA 959985 dcuA Escherichia coli O157:H7 str. EDL933 anaerobic C4-dicarboxylate transporter NP_290771.1 5249908 R 155864 CDS NP_290772.1 15804731 959984 complement(5251327..5252808) 1 NC_002655.2 catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase 5252808 aspA 959984 aspA Escherichia coli O157:H7 str. EDL933 aspartate ammonia-lyase NP_290772.1 5251327 R 155864 CDS NP_290773.2 161367460 959983 5253100..5253576 1 NC_002655.2 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA protein 5253576 fxsA 959983 fxsA Escherichia coli O157:H7 str. EDL933 FxsA protein NP_290773.2 5253100 D 155864 CDS NP_290774.1 15804733 959982 complement(5253592..5254848) 1 NC_002655.2 uncharacterized member of the APC superfamily of amino acid transporters; unknown function; hypothetical protein 5254848 yjeH 959982 yjeH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290774.1 5253592 R 155864 CDS NP_290775.1 15804734 959981 5255124..5255417 1 NC_002655.2 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 5255417 groES 959981 groES Escherichia coli O157:H7 str. EDL933 co-chaperonin GroES NP_290775.1 5255124 D 155864 CDS NP_290776.1 15804735 959980 5255461..5257107 1 NC_002655.2 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL 5257107 groEL 959980 groEL Escherichia coli O157:H7 str. EDL933 molecular chaperone GroEL NP_290776.1 5255461 D 155864 CDS NP_290777.1 15804736 959979 5257212..5257598 1 NC_002655.2 hypothetical protein 5257598 yjeI 959979 yjeI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290777.1 5257212 D 155864 CDS NP_290778.1 15804737 959978 complement(5257791..5258660) 1 NC_002655.2 hypothetical protein 5258660 yjeJ 959978 yjeJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290778.1 5257791 R 155864 CDS NP_290779.1 15804738 959977 complement(5258895..5259923) 1 NC_002655.2 hypothetical protein 5259923 yjeK 959977 yjeK Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290779.1 5258895 R 155864 CDS NP_290780.1 15804739 959976 5259965..5260531 1 NC_002655.2 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 5260531 efp 959976 efp Escherichia coli O157:H7 str. EDL933 elongation factor P NP_290780.1 5259965 D 155864 CDS NP_290781.1 15804740 959975 5260583..5260708 1 NC_002655.2 acts as and antidote to the bacteriolytic entericidin B in the EcnAB toxin-antitoxin complex; entericidin A 5260708 ecnA 959975 ecnA Escherichia coli O157:H7 str. EDL933 entericidin A NP_290781.1 5260583 D 155864 CDS NP_290782.1 15804741 959974 5260819..5260965 1 NC_002655.2 No significant matches; entericidin B 5260965 ecnB 959974 ecnB Escherichia coli O157:H7 str. EDL933 entericidin B NP_290782.1 5260819 D 155864 CDS NP_290783.1 15804742 959973 5260991..5261458 1 NC_002655.2 suppresses groEL, may be chaperone 5261458 sugE 959973 sugE Escherichia coli O157:H7 str. EDL933 suppresses groEL, may be chaperone NP_290783.1 5260991 D 155864 CDS NP_290784.1 15804743 959972 complement(5261455..5261988) 1 NC_002655.2 lipocalin; globomycin-sensitive outer membrane lipoprotein; outer membrane lipoprotein Blc 5261988 blc 959972 blc Escherichia coli O157:H7 str. EDL933 outer membrane lipoprotein Blc NP_290784.1 5261455 R 155864 CDS NP_290785.1 15804744 959971 complement(5262076..5263209) 1 NC_002655.2 beta-lactamase 5263209 ampC 959971 ampC Escherichia coli O157:H7 str. EDL933 beta-lactamase NP_290785.1 5262076 R 155864 CDS NP_290786.1 15804745 959970 complement(5263272..5263631) 1 NC_002655.2 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D 5263631 frdD 959970 frdD Escherichia coli O157:H7 str. EDL933 fumarate reductase subunit D NP_290786.1 5263272 R 155864 CDS NP_290787.1 15804746 959969 complement(5263642..5264037) 1 NC_002655.2 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C 5264037 frdC 959969 frdC Escherichia coli O157:H7 str. EDL933 fumarate reductase subunit C NP_290787.1 5263642 R 155864 CDS NP_290788.1 15804747 959968 complement(5264048..5264782) 1 NC_002655.2 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase iron-sulfur subunit 5264782 frdB 959968 frdB Escherichia coli O157:H7 str. EDL933 fumarate reductase iron-sulfur subunit NP_290788.1 5264048 R 155864 CDS NP_290789.1 15804748 959967 complement(5264775..5266583) 1 NC_002655.2 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit 5266583 frdA 959967 frdA Escherichia coli O157:H7 str. EDL933 fumarate reductase flavoprotein subunit NP_290789.1 5264775 R 155864 CDS NP_290790.2 161367459 959966 5266908..5267885 1 NC_002655.2 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 5267885 yjeA 959966 yjeA Escherichia coli O157:H7 str. EDL933 lysyl-tRNA synthetase NP_290790.2 5266908 D 155864 CDS NP_290791.1 15804750 959965 5268104..5269606 1 NC_002655.2 transport 5269606 yjeM 959965 yjeM Escherichia coli O157:H7 str. EDL933 transport NP_290791.1 5268104 D 155864 CDS NP_290792.1 15804751 959964 complement(5269757..5273080) 1 NC_002655.2 hypothetical protein 5273080 yjeP 959964 yjeP Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290792.1 5269757 R 155864 CDS NP_290793.1 15804752 959963 complement(5273102..5274070) 1 NC_002655.2 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase 5274070 psd 959963 psd Escherichia coli O157:H7 str. EDL933 phosphatidylserine decarboxylase NP_290793.1 5273102 R 155864 CDS NP_290794.2 161367458 959962 complement(5274167..5275219) 1 NC_002655.2 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 5275219 yjeQ 959962 yjeQ Escherichia coli O157:H7 str. EDL933 ribosome-associated GTPase NP_290794.2 5274167 R 155864 CDS NP_290795.2 161367457 959961 5275314..5275859 1 NC_002655.2 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 5275859 yjeR 959961 yjeR Escherichia coli O157:H7 str. EDL933 oligoribonuclease NP_290795.2 5275314 D 155864 CDS NP_290796.1 15804755 959957 complement(5276638..5277777) 1 NC_002655.2 hypothetical protein 5277777 yjeS 959957 yjeS Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290796.1 5276638 R 155864 CDS NP_290797.1 15804756 959956 5277776..5279323 1 NC_002655.2 hypothetical protein 5279323 yjeF 959956 yjeF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290797.1 5277776 D 155864 CDS NP_290798.1 15804757 959955 5279295..5279756 1 NC_002655.2 possibly involved in cell wall synthesis; ATPase 5279756 yjeE 959955 yjeE Escherichia coli O157:H7 str. EDL933 ATPase NP_290798.1 5279295 D 155864 CDS NP_290799.1 15804758 959954 5279775..5281112 1 NC_002655.2 N-acetylmuramoyl-L-alanine amidase 5281112 amiB 959954 amiB Escherichia coli O157:H7 str. EDL933 N-acetylmuramoyl-L-alanine amidase NP_290799.1 5279775 D 155864 CDS NP_290800.1 15804759 959953 5281122..5282969 1 NC_002655.2 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 5282969 mutL 959953 mutL Escherichia coli O157:H7 str. EDL933 DNA mismatch repair protein NP_290800.1 5281122 D 155864 CDS NP_290801.1 15804760 959952 5282962..5283912 1 NC_002655.2 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 5283912 miaA 959952 miaA Escherichia coli O157:H7 str. EDL933 tRNA delta(2)-isopentenylpyrophosphate transferase NP_290801.1 5282962 D 155864 CDS NP_290802.1 15804761 959951 5283998..5284306 1 NC_002655.2 Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq 5284306 hfq 959951 hfq Escherichia coli O157:H7 str. EDL933 RNA-binding protein Hfq NP_290802.1 5283998 D 155864 CDS NP_290803.1 15804762 959950 5284383..5285663 1 NC_002655.2 involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein; GTPase HflX 5285663 hflX 959950 hflX Escherichia coli O157:H7 str. EDL933 GTPase HflX NP_290803.1 5284383 D 155864 CDS NP_290804.1 15804763 959949 5285749..5287008 1 NC_002655.2 with HflC inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflK 5287008 hflK 959949 hflK Escherichia coli O157:H7 str. EDL933 FtsH protease regulator HflK NP_290804.1 5285749 D 155864 CDS NP_290805.1 15804764 959948 5287011..5288015 1 NC_002655.2 with HflK inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflC 5288015 hflC 959948 hflC Escherichia coli O157:H7 str. EDL933 FtsH protease regulator HflC NP_290805.1 5287011 D 155864 CDS NP_290806.1 15804765 959947 5288097..5288294 1 NC_002655.2 hypothetical protein 5288294 yjeT 959947 yjeT Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290806.1 5288097 D 155864 CDS NP_290807.1 15804766 959946 5288398..5289696 1 NC_002655.2 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 5289696 purA 959946 purA Escherichia coli O157:H7 str. EDL933 adenylosuccinate synthetase NP_290807.1 5288398 D 155864 CDS NP_290808.1 15804767 959945 5289902..5290327 1 NC_002655.2 negatively regulates the transcription of genes upregulated by nitrosative stress; transcriptional repressor NsrR 5290327 yjeB 959945 yjeB Escherichia coli O157:H7 str. EDL933 transcriptional repressor NsrR NP_290808.1 5289902 D 155864 CDS NP_290809.2 161367456 959944 5290366..5292807 1 NC_002655.2 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs; exoribonuclease R 5292807 vacB 959944 vacB Escherichia coli O157:H7 str. EDL933 exoribonuclease R NP_290809.2 5290366 D 155864 CDS NP_290810.1 15804769 959943 5292988..5293719 1 NC_002655.2 Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase 5293719 yjfH 959943 yjfH Escherichia coli O157:H7 str. EDL933 23S rRNA (guanosine-2'-O-)-methyltransferase NP_290810.1 5292988 D 155864 CDS NP_290811.1 15804770 959942 5293846..5294247 1 NC_002655.2 hypothetical protein 5294247 yjfI 959942 yjfI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290811.1 5293846 D 155864 CDS NP_290812.1 15804771 959941 5294266..5294964 1 NC_002655.2 alpha helical protein 5294964 yjfJ 959941 yjfJ Escherichia coli O157:H7 str. EDL933 alpha helical protein NP_290812.1 5294266 D 155864 CDS NP_290813.1 15804772 959940 5295015..5295674 1 NC_002655.2 hypothetical protein 5295674 yjfK 959940 yjfK Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290813.1 5295015 D 155864 CDS NP_290814.1 15804773 959939 5295692..5296090 1 NC_002655.2 hypothetical protein 5296090 yjfL 959939 yjfL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290814.1 5295692 D 155864 CDS NP_290815.1 15804774 959938 5296100..5296738 1 NC_002655.2 hypothetical protein 5296738 yjfM 959938 yjfM Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290815.1 5296100 D 155864 CDS NP_290816.1 15804775 959937 5296741..5297904 1 NC_002655.2 synthetase/amidase 5297904 yjfC 959937 yjfC Escherichia coli O157:H7 str. EDL933 synthetase/amidase NP_290816.1 5296741 D 155864 CDS NP_290817.1 15804776 959936 5297973..5299613 1 NC_002655.2 catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA; isovaleryl CoA dehydrogenase 5299613 aidB 959936 aidB Escherichia coli O157:H7 str. EDL933 isovaleryl CoA dehydrogenase NP_290817.1 5297973 D 155864 CDS NP_290818.1 15804777 959935 complement(5299730..5300032) 1 NC_002655.2 hypothetical protein 5300032 yjfN 959935 yjfN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290818.1 5299730 R 155864 CDS NP_290819.2 161367455 959934 complement(5300154..5300483) 1 NC_002655.2 in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility; biofilm stress and motility protein A 5300483 yjfO 959934 yjfO Escherichia coli O157:H7 str. EDL933 biofilm stress and motility protein A NP_290819.2 5300154 R 155864 CDS NP_290820.1 15804779 959933 5300665..5301414 1 NC_002655.2 YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo; esterase 5301414 yjfP 959933 yjfP Escherichia coli O157:H7 str. EDL933 esterase NP_290820.1 5300665 D 155864 CDS NP_290821.1 15804780 959932 complement(5301411..5302166) 1 NC_002655.2 negative regulator of ulaG and ulaABCDEF; transcriptional repressor UlaR 5302166 yjfQ 959932 yjfQ Escherichia coli O157:H7 str. EDL933 transcriptional repressor UlaR NP_290821.1 5301411 R 155864 CDS NP_290822.1 15804781 959931 complement(5302274..5303344) 1 NC_002655.2 L-ascorbate 6-phosphate lactonase 5303344 yjfR 959931 yjfR Escherichia coli O157:H7 str. EDL933 L-ascorbate 6-phosphate lactonase NP_290822.1 5302274 R 155864 CDS NP_290823.2 161367454 959930 5303693..5305090 1 NC_002655.2 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 5305090 ulaA 959930 ulaA Escherichia coli O157:H7 str. EDL933 PTS system ascorbate-specific transporter subunit IIC NP_290823.2 5303693 D 155864 CDS NP_290824.1 15804783 959929 5305106..5305411 1 NC_002655.2 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIB 5305411 sgaB 959929 sgaB Escherichia coli O157:H7 str. EDL933 PTS system L-ascorbate-specific transporter subunit IIB NP_290824.1 5305106 D 155864 CDS NP_290825.1 15804784 959928 5305421..5305885 1 NC_002655.2 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIA 5305885 ptxA 959928 ptxA Escherichia coli O157:H7 str. EDL933 PTS system L-ascorbate-specific transporter subunit IIA NP_290825.1 5305421 D 155864 CDS NP_290826.1 15804785 959927 5305899..5306549 1 NC_002655.2 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 5306549 ulaD 959927 ulaD Escherichia coli O157:H7 str. EDL933 3-keto-L-gulonate-6-phosphate decarboxylase NP_290826.1 5305899 D 155864 CDS NP_290827.1 15804786 959926 5306559..5307413 1 NC_002655.2 UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway; L-xylulose 5-phosphate 3-epimerase 5307413 sgaU 959926 sgaU Escherichia coli O157:H7 str. EDL933 L-xylulose 5-phosphate 3-epimerase NP_290827.1 5306559 D 155864 CDS NP_290828.1 15804787 959925 5307413..5308099 1 NC_002655.2 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 5308099 sgaE 959925 sgaE Escherichia coli O157:H7 str. EDL933 L-ribulose-5-phosphate 4-epimerase NP_290828.1 5307413 D 155864 CDS NP_290829.1 15804788 959924 complement(5308228..5308503) 1 NC_002655.2 hypothetical protein 5308503 yjfY 959924 yjfY Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290829.1 5308228 R 155864 CDS NP_290830.1 15804789 959923 5308830..5309225 1 NC_002655.2 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 5309225 rpsF 959923 rpsF Escherichia coli O157:H7 str. EDL933 30S ribosomal protein S6 NP_290830.1 5308830 D 155864 CDS NP_290831.1 15804790 959922 5309232..5309546 1 NC_002655.2 binds single-stranded DNA at the primosome assembly site; primosomal replication protein N 5309546 priB 959922 priB Escherichia coli O157:H7 str. EDL933 primosomal replication protein N NP_290831.1 5309232 D 155864 CDS NP_290832.1 15804791 959921 5309551..5309778 1 NC_002655.2 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 5309778 rpsR 959921 rpsR Escherichia coli O157:H7 str. EDL933 30S ribosomal protein S18 NP_290832.1 5309551 D 155864 CDS NP_290833.1 15804792 959920 5309820..5310269 1 NC_002655.2 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 5310269 rplI 959920 rplI Escherichia coli O157:H7 str. EDL933 50S ribosomal protein L9 NP_290833.1 5309820 D 155864 CDS NP_290834.1 15804793 959919 complement(5310340..5311134) 1 NC_002655.2 hypothetical protein 5311134 yjfZ 959919 yjfZ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290834.1 5310340 R 155864 CDS NP_290835.1 15804794 959918 complement(5311574..5311756) 1 NC_002655.2 No significant matches; hypothetical protein 5311756 959918 Z5814 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290835.1 5311574 R 155864 CDS NP_290836.1 15804795 959917 complement(5311757..5312173) 1 NC_002655.2 transposase 5312173 959917 Z5815 Escherichia coli O157:H7 str. EDL933 transposase NP_290836.1 5311757 R 155864 CDS NP_290837.1 15804796 959916 5312196..5313404 1 NC_002655.2 virulence protein 5313404 959916 Z5816 Escherichia coli O157:H7 str. EDL933 virulence protein NP_290837.1 5312196 D 155864 CDS NP_290838.1 15804797 959915 complement(5313539..5314213) 1 NC_002655.2 hypothetical protein 5314213 ytfB 959915 ytfB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290838.1 5313539 R 155864 CDS NP_290839.2 161367453 959914 5314395..5315015 1 NC_002655.2 FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; peptidyl-prolyl cis-trans isomerase 5315015 fklB 959914 fklB Escherichia coli O157:H7 str. EDL933 peptidyl-prolyl cis-trans isomerase NP_290839.2 5314395 D 155864 CDS NP_290840.1 15804799 959913 5315324..5316736 1 NC_002655.2 involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; D-alanine/D-serine/glycine permease 5316736 cycA 959913 cycA Escherichia coli O157:H7 str. EDL933 D-alanine/D-serine/glycine permease NP_290840.1 5315324 D 155864 CDS NP_290841.1 15804800 959912 complement(5316781..5317443) 1 NC_002655.2 Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein 5317443 ytfE 959912 ytfE Escherichia coli O157:H7 str. EDL933 iron-sulfur cluster repair di-iron protein NP_290841.1 5316781 R 155864 CDS NP_290842.1 15804801 959911 complement(5317551..5318525) 1 NC_002655.2 transmembrane subunit 5318525 ytfF 959911 ytfF Escherichia coli O157:H7 str. EDL933 transmembrane subunit NP_290842.1 5317551 R 155864 CDS NP_290843.1 15804802 959910 complement(5318624..5319484) 1 NC_002655.2 oxidoreductase 5319484 ytfG 959910 ytfG Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_290843.1 5318624 R 155864 CDS NP_290844.1 15804803 959909 5319483..5319953 1 NC_002655.2 hypothetical protein 5319953 ytfH 959909 ytfH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290844.1 5319483 D 155864 CDS NP_290845.1 15804804 959908 complement(5320071..5322014) 1 NC_002655.2 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein 5322014 cpdB 959908 cpdB Escherichia coli O157:H7 str. EDL933 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein NP_290845.1 5320071 R 155864 CDS NP_290846.1 15804805 959907 5322204..5322944 1 NC_002655.2 catalyzes the formation of AMP from adenosine-3',5'-bisphosphate; adenosine-3'(2'),5'-bisphosphate nucleotidase 5322944 cysQ 959907 cysQ Escherichia coli O157:H7 str. EDL933 adenosine-3'(2'),5'-bisphosphate nucleotidase NP_290846.1 5322204 D 155864 CDS NP_290847.1 15804806 959906 5323156..5324094 1 NC_002655.2 hypothetical protein 5324094 959906 Z5826 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290847.1 5323156 D 155864 CDS NP_290848.1 15804807 959905 complement(5324157..5324711) 1 NC_002655.2 hypothetical protein 5324711 ytfJ 959905 ytfJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290848.1 5324157 R 155864 CDS NP_290849.1 15804808 959904 5324997..5325242 1 NC_002655.2 hypothetical protein 5325242 ytfK 959904 ytfK Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290849.1 5324997 D 155864 CDS NP_290850.1 15804809 959903 complement(5325338..5326681) 1 NC_002655.2 transporter 5326681 ytfL 959903 ytfL Escherichia coli O157:H7 str. EDL933 transporter NP_290850.1 5325338 R 155864 CDS NP_290851.1 15804810 959902 complement(5327004..5327642) 1 NC_002655.2 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 5327642 msrA 959902 msrA Escherichia coli O157:H7 str. EDL933 methionine sulfoxide reductase A NP_290851.1 5327004 R 155864 CDS NP_290852.1 15804811 959881 5327848..5329581 1 NC_002655.2 hypothetical protein 5329581 ytfM 959881 ytfM Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290852.1 5327848 D 155864 CDS NP_290853.1 15804812 959868 5329578..5333357 1 NC_002655.2 hypothetical protein 5333357 ytfN 959868 ytfN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290853.1 5329578 D 155864 CDS NP_290854.1 15804813 959842 5333360..5333701 1 NC_002655.2 hypothetical protein 5333701 ytfP 959842 ytfP Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290854.1 5333360 D 155864 CDS NP_290855.1 15804814 959819 complement(5333442..5333711) 1 NC_002655.2 hypothetical protein 5333711 yjfA 959819 yjfA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290855.1 5333442 R 155864 CDS NP_290856.1 15804815 959818 5333907..5334164 1 NC_002655.2 part of the toxin-antitoxin ChpB-ChpS system; antitoxin ChpS 5334164 chpS 959818 chpS Escherichia coli O157:H7 str. EDL933 antitoxin ChpS NP_290856.1 5333907 D 155864 CDS NP_290857.1 15804816 959817 5334158..5334508 1 NC_002655.2 toxin of the ChpB-ChpS toxin-antitoxin system; toxin ChpB 5334508 chpB 959817 chpB Escherichia coli O157:H7 str. EDL933 toxin ChpB NP_290857.1 5334158 D 155864 CDS NP_290858.1 15804817 959816 complement(5334588..5335118) 1 NC_002655.2 catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase 5335118 ppa 959816 ppa Escherichia coli O157:H7 str. EDL933 inorganic pyrophosphatase NP_290858.1 5334588 R 155864 CDS NP_290859.1 15804818 959815 5335428..5336384 1 NC_002655.2 LACI-type transcriptional regulator 5336384 ytfQ 959815 ytfQ Escherichia coli O157:H7 str. EDL933 LACI-type transcriptional regulator NP_290859.1 5335428 D 155864 CDS NP_290860.1 15804819 959814 5336524..5338026 1 NC_002655.2 ABC transporter ATP-binding protein 5338026 959814 Z5839 Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_290860.1 5336524 D 155864 CDS NP_290861.1 15804820 959813 5338037..5339062 1 NC_002655.2 transport system permease 5339062 ytfT 959813 ytfT Escherichia coli O157:H7 str. EDL933 transport system permease NP_290861.1 5338037 D 155864 CDS NP_290862.1 15804821 959811 5339073..5340044 1 NC_002655.2 membrane component of a sugar ABC transporter system; ABC transporter permease 5340044 yjfF 959811 yjfF Escherichia coli O157:H7 str. EDL933 ABC transporter permease NP_290862.1 5339073 D 155864 CDS NP_290863.1 15804822 959809 complement(5340077..5341075) 1 NC_002655.2 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase 5341075 fbp 959809 fbp Escherichia coli O157:H7 str. EDL933 fructose-1,6-bisphosphatase NP_290863.1 5340077 R 155864 CDS NP_290864.1 15804823 959808 5341251..5342624 1 NC_002655.2 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase 5342624 yjfG 959808 yjfG Escherichia coli O157:H7 str. EDL933 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase NP_290864.1 5341251 D 155864 CDS NP_290865.1 15804824 959807 complement(5342780..5343331) 1 NC_002655.2 hypothetical protein 5343331 yjgA 959807 yjgA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290865.1 5342780 R 155864 CDS NP_290866.1 15804825 959805 5343425..5344777 1 NC_002655.2 protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD; peptidase PmbA 5344777 pmbA 959805 pmbA Escherichia coli O157:H7 str. EDL933 peptidase PmbA NP_290866.1 5343425 D 155864 CDS NP_290867.1 15804826 959804 5345045..5345347 1 NC_002655.2 cytochrome b562 5345347 cybC 959804 cybC Escherichia coli O157:H7 str. EDL933 cytochrome b562 NP_290867.1 5345045 D 155864 CDS NP_290868.1 15804827 959803 complement(5345392..5345856) 1 NC_002655.2 activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein 5345856 nrdG 959803 nrdG Escherichia coli O157:H7 str. EDL933 anaerobic ribonucleotide reductase-activating protein NP_290868.1 5345392 R 155864 CDS NP_290869.1 15804828 959802 complement(5346046..5348184) 1 NC_002655.2 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 5348184 nrdD 959802 nrdD Escherichia coli O157:H7 str. EDL933 anaerobic ribonucleoside triphosphate reductase NP_290869.1 5346046 R 155864 CDS NP_290870.1 15804829 959801 complement(5348578..5350233) 1 NC_002655.2 trehalose-6-phosphate hydrolase 5350233 treC 959801 treC Escherichia coli O157:H7 str. EDL933 trehalose-6-phosphate hydrolase NP_290870.1 5348578 R 155864 CDS NP_290871.1 15804830 959800 complement(5350283..5351704) 1 NC_002655.2 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system trehalose(maltose)-specific transporter subunit IIBC 5351704 treB 959800 treB Escherichia coli O157:H7 str. EDL933 PTS system trehalose(maltose)-specific transporter subunit IIBC NP_290871.1 5350283 R 155864 CDS NP_290872.1 15804831 959799 complement(5351823..5352770) 1 NC_002655.2 regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon; trehalose repressor 5352770 treR 959799 treR Escherichia coli O157:H7 str. EDL933 trehalose repressor NP_290872.1 5351823 R 155864 CDS NP_290873.1 15804832 959798 5352819..5353007 1 NC_002655.2 No significant matches; hypothetical protein 5353007 959798 Z5852 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290873.1 5352819 D 155864 CDS NP_290874.1 15804833 959797 5353148..5355844 1 NC_002655.2 P-type ATPase involved in magnesium influx; magnesium-transporting ATPase MgtA 5355844 mgtA 959797 mgtA Escherichia coli O157:H7 str. EDL933 magnesium-transporting ATPase MgtA NP_290874.1 5353148 D 155864 CDS NP_290875.1 15804834 959796 complement(5356050..5356475) 1 NC_002655.2 hypothetical protein 5356475 yjgF 959796 yjgF Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290875.1 5356050 R 155864 CDS NP_290876.1 15804835 959795 complement(5356509..5356970) 1 NC_002655.2 involved in the allosteric regulation of aspartate carbamoyltransferase; aspartate carbamoyltransferase 5356970 pyrI 959795 pyrI Escherichia coli O157:H7 str. EDL933 aspartate carbamoyltransferase NP_290876.1 5356509 R 155864 CDS NP_290877.1 15804836 959794 complement(5356983..5357918) 1 NC_002655.2 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase 5357918 pyrB 959794 pyrB Escherichia coli O157:H7 str. EDL933 aspartate carbamoyltransferase NP_290877.1 5356983 R 155864 CDS NP_290878.1 15804837 959793 complement(5357922..5358056) 1 NC_002655.2 pyrBI operon leader peptide 5358056 pyrL 959793 pyrL Escherichia coli O157:H7 str. EDL933 pyrBI operon leader peptide NP_290878.1 5357922 R 155864 CDS NP_290879.1 15804838 959792 5358036..5358158 1 NC_002655.2 hypothetical protein 5358158 yjgG_1 959792 yjgG_1 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290879.1 5358036 D 155864 CDS NP_290880.1 15804839 959791 5358186..5358368 1 NC_002655.2 hypothetical protein 5358368 yjgG_2 959791 yjgG_2 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290880.1 5358186 D 155864 CDS NP_290881.1 15804840 959789 complement(5358337..5358732) 1 NC_002655.2 hypothetical protein 5358732 yjgH 959789 yjgH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290881.1 5358337 R 155864 CDS NP_290882.1 15804841 959788 complement(5358863..5359576) 1 NC_002655.2 oxidoreductase 5359576 yjgI 959788 yjgI Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_290882.1 5358863 R 155864 CDS NP_290883.1 15804842 959787 5359750..5359914 1 NC_002655.2 hypothetical protein 5359914 959787 Z5863 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290883.1 5359750 D 155864 CDS NP_290884.1 15804843 959786 5359986..5360240 1 NC_002655.2 hypothetical protein 5360240 yjgJ 959786 yjgJ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290884.1 5359986 D 155864 CDS NP_290885.1 15804844 959785 5360376..5360837 1 NC_002655.2 hypothetical protein 5360837 yjgK 959785 yjgK Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290885.1 5360376 D 155864 CDS NP_290886.1 15804845 959784 5360960..5362750 1 NC_002655.2 hypothetical protein 5362750 yjgL 959784 yjgL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290886.1 5360960 D 155864 CDS NP_290887.1 15804846 959783 complement(5362807..5363811) 1 NC_002655.2 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III.; ornithine carbamoyltransferase subunit I 5363811 argI 959783 argI Escherichia coli O157:H7 str. EDL933 ornithine carbamoyltransferase subunit I NP_290887.1 5362807 R 155864 CDS NP_290888.1 15804847 959782 5363973..5364389 1 NC_002655.2 hypothetical protein 5364389 yjgD 959782 yjgD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290888.1 5363973 D 155864 CDS NP_290889.1 15804848 959781 complement(5364435..5364728) 1 NC_002655.2 hypothetical protein 5364728 959781 Z5868 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290889.1 5364435 R 155864 CDS NP_290890.1 15804849 959780 5365104..5366327 1 NC_002655.2 hypothetical protein 5366327 yjgN 959780 yjgN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290890.1 5365104 D 155864 CDS NP_290891.1 15804850 959779 complement(5366382..5369237) 1 NC_002655.2 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 5369237 valS 959779 valS Escherichia coli O157:H7 str. EDL933 valyl-tRNA synthetase NP_290891.1 5366382 R 155864 CDS NP_290892.1 15804851 959778 complement(5369237..5369680) 1 NC_002655.2 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi 5369680 holC 959778 holC Escherichia coli O157:H7 str. EDL933 DNA polymerase III subunit chi NP_290892.1 5369237 R 155864 CDS NP_290893.1 15804852 959777 complement(5370034..5371545) 1 NC_002655.2 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 5371545 pepA 959777 pepA Escherichia coli O157:H7 str. EDL933 leucyl aminopeptidase NP_290893.1 5370034 R 155864 CDS NP_290894.1 15804853 959776 5371812..5372912 1 NC_002655.2 hypothetical protein 5372912 yjgP 959776 yjgP Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290894.1 5371812 D 155864 CDS NP_290895.1 15804854 959775 5372909..5373994 1 NC_002655.2 hypothetical protein 5373994 yjgQ 959775 yjgQ Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290895.1 5372909 D 155864 CDS NP_290896.1 15804855 959774 complement(5374155..5375657) 1 NC_002655.2 hypothetical protein 5375657 yjgR 959774 yjgR Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290896.1 5374155 R 155864 CDS NP_290897.1 15804856 959773 complement(5375787..5376848) 1 NC_002655.2 oxidoreductase 5376848 yjgB 959773 yjgB Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_290897.1 5375787 R 155864 CDS NP_290898.1 15804857 959771 5377177..5379126 1 NC_002655.2 No significant matches; integrase 5379126 959771 Z5878 Escherichia coli O157:H7 str. EDL933 integrase NP_290898.1 5377177 D 155864 CDS NP_290899.1 15804858 959770 5379326..5379652 1 NC_002655.2 hypothetical protein 5379652 959770 Z5879 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290899.1 5379326 D 155864 CDS NP_290900.1 15804859 959769 5379892..5380539 1 NC_002655.2 transposase 5380539 959769 Z5880 Escherichia coli O157:H7 str. EDL933 transposase NP_290900.1 5379892 D 155864 CDS NP_290901.1 15804860 959768 complement(5380722..5381099) 1 NC_002655.2 No significant matches; hypothetical protein 5381099 959768 Z5881 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290901.1 5380722 R 155864 CDS NP_290902.1 15804861 959767 complement(5381221..5381487) 1 NC_002655.2 No significant matches; hypothetical protein 5381487 959767 Z5882 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290902.1 5381221 R 155864 CDS NP_290904.1 15804863 959765 complement(5382557..5383024) 1 NC_002655.2 hypothetical protein 5383024 959765 Z5884 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290904.1 5382557 R 155864 CDS NP_290905.1 15804864 959764 5383211..5383786 1 NC_002655.2 resolvase 5383786 959764 Z5885 Escherichia coli O157:H7 str. EDL933 resolvase NP_290905.1 5383211 D 155864 CDS NP_290906.1 15804865 959763 complement(5383985..5385301) 1 NC_002655.2 No significant matches; hypothetical protein 5385301 959763 Z5886 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290906.1 5383985 R 155864 CDS NP_290907.1 15804866 959762 complement(5385453..5386226) 1 NC_002655.2 No significant matches; hypothetical protein 5386226 959762 Z5887 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290907.1 5385453 R 155864 CDS NP_290908.1 15804867 959761 5386343..5386807 1 NC_002655.2 hypothetical protein 5386807 959761 Z5888 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290908.1 5386343 D 155864 CDS NP_290909.1 15804868 959760 5386840..5386941 1 NC_002655.2 No significant matches; hypothetical protein 5386941 959760 Z5889 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290909.1 5386840 D 155864 CDS NP_290910.1 15804869 959759 5387445..5388350 1 NC_002655.2 integrase 5388350 959759 Z5890 Escherichia coli O157:H7 str. EDL933 integrase NP_290910.1 5387445 D 155864 CDS NP_290911.1 15804870 959758 5388464..5388577 1 NC_002655.2 No significant matches; hypothetical protein 5388577 959758 Z5891 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290911.1 5388464 D 155864 CDS NP_290912.1 15804871 959757 complement(5388810..5389694) 1 NC_002655.2 hypothetical protein 5389694 959757 Z5892 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290912.1 5388810 R 155864 CDS NP_290913.1 15804872 959756 complement(5389648..5389971) 1 NC_002655.2 hypothetical protein 5389971 959756 Z5893 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290913.1 5389648 R 155864 CDS NP_290914.1 15804873 959755 complement(5390202..5391305) 1 NC_002655.2 No significant matches; hypothetical protein 5391305 959755 Z5894 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290914.1 5390202 R 155864 CDS NP_290915.1 15804874 959754 complement(5391309..5392016) 1 NC_002655.2 No significant matches; hypothetical protein 5392016 959754 Z5895 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290915.1 5391309 R 155864 CDS NP_290916.1 15804875 959753 complement(5392023..5393675) 1 NC_002655.2 hypothetical protein 5393675 959753 Z5896 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290916.1 5392023 R 155864 CDS NP_290917.1 15804876 959752 5393893..5397246 1 NC_002655.2 hypothetical protein 5397246 959752 Z5897 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290917.1 5393893 D 155864 CDS NP_290918.1 15804877 959751 5397246..5403560 1 NC_002655.2 hypothetical protein 5403560 959751 Z5898 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290918.1 5397246 D 155864 CDS NP_290919.1 15804878 959750 5403784..5406642 1 NC_002655.2 ATP-dependent helicase 5406642 959750 Z5899 Escherichia coli O157:H7 str. EDL933 ATP-dependent helicase NP_290919.1 5403784 D 155864 CDS NP_290920.1 15804879 959749 5406645..5411579 1 NC_002655.2 hypothetical protein 5411579 959749 Z5900 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290920.1 5406645 D 155864 CDS NP_290921.1 15804880 959748 5411579..5417920 1 NC_002655.2 helicase 5417920 959748 Z5901 Escherichia coli O157:H7 str. EDL933 helicase NP_290921.1 5411579 D 155864 CDS NP_290922.1 15804881 959747 5417917..5420031 1 NC_002655.2 helicase 5420031 959747 Z5902 Escherichia coli O157:H7 str. EDL933 helicase NP_290922.1 5417917 D 155864 CDS NP_290924.1 15804883 959745 complement(5420984..5421229) 1 NC_002655.2 hypothetical protein 5421229 959745 Z5904 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290924.1 5420984 R 155864 CDS NP_290925.1 15804884 959744 complement(5421525..5422505) 1 NC_002655.2 hypothetical protein 5422505 yjhS 959744 yjhS Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290925.1 5421525 R 155864 CDS NP_290926.1 15804885 959743 complement(5422570..5423784) 1 NC_002655.2 N-acetylneuraminic acid mutarotase 5423784 yjhT 959743 yjhT Escherichia coli O157:H7 str. EDL933 N-acetylneuraminic acid mutarotase NP_290926.1 5422570 R 155864 CDS NP_290927.1 15804886 959742 complement(5423696..5424421) 1 NC_002655.2 hypothetical protein 5424421 yjhA 959742 yjhA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290927.1 5423696 R 155864 CDS NP_290928.1 15804887 959741 5425868..5426470 1 NC_002655.2 inversion of on/off regulator of fimA; tyrosine recombinase 5426470 fimB 959741 fimB Escherichia coli O157:H7 str. EDL933 tyrosine recombinase NP_290928.1 5425868 D 155864 CDS NP_290929.1 15804888 959740 5426948..5427544 1 NC_002655.2 inversion of on/off regulator of fimA; tyrosine recombinase 5427544 fimE 959740 fimE Escherichia coli O157:H7 str. EDL933 tyrosine recombinase NP_290929.1 5426948 D 155864 CDS NP_290930.1 15804889 959739 5428009..5428557 1 NC_002655.2 major type 1 subunit fimbrin (pilin) 5428557 fimA 959739 fimA Escherichia coli O157:H7 str. EDL933 major type 1 subunit fimbrin (pilin) NP_290930.1 5428009 D 155864 CDS NP_290931.1 15804890 959738 5428514..5429161 1 NC_002655.2 fimbrial protein 5429161 fimI 959738 fimI Escherichia coli O157:H7 str. EDL933 fimbrial protein NP_290931.1 5428514 D 155864 CDS NP_290932.1 15804891 959737 5429198..5429923 1 NC_002655.2 periplasmic chaperone, required for type 1 fimbriae 5429923 fimC 959737 fimC Escherichia coli O157:H7 str. EDL933 periplasmic chaperone, required for type 1 fimbriae NP_290932.1 5429198 D 155864 CDS NP_290933.1 15804892 959736 5429990..5432626 1 NC_002655.2 outer membrane protein; export and assembly of type 1 fimbriae, interrupted 5432626 fimD 959736 fimD Escherichia coli O157:H7 str. EDL933 outer membrane protein; export and assembly of type 1 fimbriae, interrupted NP_290933.1 5429990 D 155864 CDS NP_290934.1 15804893 959735 5432636..5433166 1 NC_002655.2 fimbrial morphology protein 5433166 fimF 959735 fimF Escherichia coli O157:H7 str. EDL933 fimbrial morphology protein NP_290934.1 5432636 D 155864 CDS NP_290935.1 15804894 959734 5433179..5433682 1 NC_002655.2 fimbrial morphology protein 5433682 fimG 959734 fimG Escherichia coli O157:H7 str. EDL933 fimbrial morphology protein NP_290935.1 5433179 D 155864 CDS NP_290936.1 15804895 959733 5433702..5434604 1 NC_002655.2 minor fimbrial subunit, D-mannose specific adhesin 5434604 fimH 959733 fimH Escherichia coli O157:H7 str. EDL933 minor fimbrial subunit, D-mannose specific adhesin NP_290936.1 5433702 D 155864 CDS NP_290937.1 15804896 959732 complement(5434778..5436121) 1 NC_002655.2 fructuronate transporter 5436121 gntP 959732 gntP Escherichia coli O157:H7 str. EDL933 fructuronate transporter NP_290937.1 5434778 R 155864 CDS NP_290938.1 15804897 959731 5436461..5437645 1 NC_002655.2 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 5437645 uxuA 959731 uxuA Escherichia coli O157:H7 str. EDL933 mannonate dehydratase NP_290938.1 5436461 D 155864 CDS NP_290939.1 15804898 959730 5437727..5439187 1 NC_002655.2 mannonate oxidoreductase 5439187 uxuB 959730 uxuB Escherichia coli O157:H7 str. EDL933 mannonate oxidoreductase NP_290939.1 5437727 D 155864 CDS NP_290940.1 15804899 959729 5439402..5440175 1 NC_002655.2 regulates the expression of uxuBA; DNA-binding transcriptional repressor UxuR 5440175 uxuR 959729 uxuR Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional repressor UxuR NP_290940.1 5439402 D 155864 CDS NP_290941.1 15804900 959728 complement(5440316..5441146) 1 NC_002655.2 hypothetical protein 5441146 yjiC 959728 yjiC Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290941.1 5440316 R 155864 CDS NP_290942.1 15804901 959727 5441480..5441623 1 NC_002655.2 No significant matches; hypothetical protein 5441623 959727 Z5924 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290942.1 5441480 D 155864 CDS NP_290943.1 15804902 959726 5441810..5442211 1 NC_002655.2 inhibitor of RssB activity in response to DNA damage; blocks degradation of stationary phase sigma factor RpoS; DNA replication/recombination/repair protein 5442211 iraD 959726 iraD Escherichia coli O157:H7 str. EDL933 DNA replication/recombination/repair protein NP_290943.1 5441810 D 155864 CDS NP_290944.1 15804903 959725 complement(5442204..5442932) 1 NC_002655.2 DNA-binding transcriptional regulator 5442932 yjiE 959725 yjiE Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional regulator NP_290944.1 5442204 R 155864 CDS NP_290945.1 15804904 959724 complement(5443180..5444352) 1 NC_002655.2 isoaspartyl dipeptidase 5444352 iadA 959724 iadA Escherichia coli O157:H7 str. EDL933 isoaspartyl dipeptidase NP_290945.1 5443180 R 155864 CDS NP_290946.1 15804905 959723 complement(5444365..5444826) 1 NC_002655.2 hypothetical protein 5444826 yjiG 959723 yjiG Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290946.1 5444365 R 155864 CDS NP_290947.1 15804906 959722 complement(5444823..5445518) 1 NC_002655.2 hypothetical protein 5445518 yjiH 959722 yjiH Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290947.1 5444823 R 155864 CDS NP_290948.1 15804907 959721 5445654..5446100 1 NC_002655.2 hypothetical protein 5446100 959721 Z5930 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290948.1 5445654 D 155864 CDS NP_290949.1 15804908 959720 complement(5446463..5451565) 1 NC_002655.2 invasin 5451565 959720 Z5932 Escherichia coli O157:H7 str. EDL933 invasin NP_290949.1 5446463 R 155864 CDS NP_290950.1 15804909 959719 complement(5451915..5453093) 1 NC_002655.2 transporter 5453093 yjiJ 959719 yjiJ Escherichia coli O157:H7 str. EDL933 transporter NP_290950.1 5451915 R 155864 CDS NP_290951.1 15804910 959718 complement(5453161..5454150) 1 NC_002655.2 hypothetical protein 5454150 yjiK 959718 yjiK Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290951.1 5453161 R 155864 CDS NP_290952.1 15804911 959717 complement(5454269..5456464) 1 NC_002655.2 hypothetical protein 5456464 959717 Z5935 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290952.1 5454269 R 155864 CDS NP_290953.1 15804912 959716 complement(5457039..5457806) 1 NC_002655.2 hypothetical protein 5457806 yjiL 959716 yjiL Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290953.1 5457039 R 155864 CDS NP_290954.1 15804913 959714 complement(5457816..5458988) 1 NC_002655.2 hypothetical protein 5458988 yjiM 959714 yjiM Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290954.1 5457816 R 155864 CDS NP_290955.1 15804914 959713 complement(5459084..5460355) 1 NC_002655.2 hypothetical protein 5460355 yjiN 959713 yjiN Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290955.1 5459084 R 155864 CDS NP_290956.1 15804915 959712 complement(5460396..5461628) 1 NC_002655.2 transporter 5461628 yjiO 959712 yjiO Escherichia coli O157:H7 str. EDL933 transporter NP_290956.1 5460396 R 155864 CDS NP_290957.1 15804916 959711 5462095..5462877 1 NC_002655.2 hypothetical protein 5462877 959711 Z5940 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290957.1 5462095 D 155864 CDS NP_290958.1 15804917 959710 complement(5463295..5464707) 1 NC_002655.2 regulator 5464707 yjiR 959710 yjiR Escherichia coli O157:H7 str. EDL933 regulator NP_290958.1 5463295 R 155864 CDS NP_290959.1 15804918 959709 5464884..5465048 1 NC_002655.2 hypothetical protein 5465048 yjiS 959709 yjiS Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290959.1 5464884 D 155864 CDS NP_290960.1 15804980 959639 join(5465145..5465948,5465948..5467237) 1 NC_002655.2 hypothetical protein 5467237 959639 Z5943m Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290960.1 5465145 D 155864 CDS NP_290961.1 15804919 959708 complement(5467284..5467625) 1 NC_002655.2 involved in the degradation of RNA; may be involved in the recycling of RNA during the SOS response; endoribonuclease SymE 5467625 959708 Z5945 Escherichia coli O157:H7 str. EDL933 endoribonuclease SymE NP_290961.1 5467284 R 155864 CDS NP_290962.1 15804920 959707 complement(5467846..5469600) 1 NC_002655.2 restriction modification enzyme S subunit 5469600 959707 Z5946 Escherichia coli O157:H7 str. EDL933 restriction modification enzyme S subunit NP_290962.1 5467846 R 155864 CDS NP_290963.1 15804921 959706 complement(5469600..5471081) 1 NC_002655.2 restriction modification enzyme subunit M 5471081 959706 Z5947 Escherichia coli O157:H7 str. EDL933 restriction modification enzyme subunit M NP_290963.1 5469600 R 155864 CDS NP_290964.1 15804922 959705 complement(5471136..5473568) 1 NC_002655.2 restriction modification enzyme subunit R 5473568 959705 Z5948 Escherichia coli O157:H7 str. EDL933 restriction modification enzyme subunit R NP_290964.1 5471136 R 155864 CDS NP_290965.1 15804923 959704 5473846..5474130 1 NC_002655.2 hypothetical protein 5474130 959704 Z5949 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290965.1 5473846 D 155864 CDS NP_290966.1 15804924 959703 5474139..5475497 1 NC_002655.2 hypothetical protein 5475497 959703 Z5950 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290966.1 5474139 D 155864 CDS NP_290967.1 15804925 959702 complement(5475566..5476420) 1 NC_002655.2 GTP-binding protein YjiA 5476420 959702 Z5951 Escherichia coli O157:H7 str. EDL933 GTP-binding protein YjiA NP_290967.1 5475566 R 155864 CDS NP_290968.1 15804926 959701 complement(5476533..5476736) 1 NC_002655.2 hypothetical protein 5476736 yjiX 959701 yjiX Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290968.1 5476533 R 155864 CDS NP_290969.1 15804927 959700 complement(5476786..5478951) 1 NC_002655.2 carbon starvation protein 5478951 yjiY 959700 yjiY Escherichia coli O157:H7 str. EDL933 carbon starvation protein NP_290969.1 5476786 R 155864 CDS NP_290970.1 15804928 959699 complement(5479229..5479771) 1 NC_002655.2 No significant matches; hypothetical protein 5479771 959699 Z5954 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290970.1 5479229 R 155864 CDS NP_290971.1 15804929 959698 5480000..5481664 1 NC_002655.2 methyl-accepting chemotaxis protein I, serine sensor receptor 5481664 tsr 959698 tsr Escherichia coli O157:H7 str. EDL933 methyl-accepting chemotaxis protein I, serine sensor receptor NP_290971.1 5480000 D 155864 CDS NP_290972.1 15804930 959697 complement(5481713..5483074) 1 NC_002655.2 transport protein, cryptic, orf, joins former yjiZ and yjjL 5483074 yjiZ 959697 yjiZ Escherichia coli O157:H7 str. EDL933 transport protein, cryptic, orf, joins former yjiZ and yjjL NP_290972.1 5481713 R 155864 CDS NP_290973.1 15804931 959696 complement(5483290..5484096) 1 NC_002655.2 hypothetical protein 5484096 yjjM 959696 yjjM Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290973.1 5483290 R 155864 CDS NP_290974.1 15804932 959695 5484328..5485365 1 NC_002655.2 oxidoreductase 5485365 yjjN 959695 yjjN Escherichia coli O157:H7 str. EDL933 oxidoreductase NP_290974.1 5484328 D 155864 CDS NP_290975.2 161367452 959694 complement(5485502..5487793) 1 NC_002655.2 catalyzes the transfer of phosphoglycerol to the glucan backbone; phosphoglycerol transferase I 5487793 mdoB 959694 mdoB Escherichia coli O157:H7 str. EDL933 phosphoglycerol transferase I NP_290975.2 5485502 R 155864 CDS NP_290976.1 15804934 959693 complement(5488047..5488544) 1 NC_002655.2 hypothetical protein 5488544 yjjA 959693 yjjA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290976.1 5488047 R 155864 CDS NP_290977.1 15804935 959692 complement(5488590..5489327) 1 NC_002655.2 acts to load the DnaB helicase onto the initiation site during DNA replication; DNA replication protein DnaC 5489327 dnaC 959692 dnaC Escherichia coli O157:H7 str. EDL933 DNA replication protein DnaC NP_290977.1 5488590 R 155864 CDS NP_290978.1 15804936 959691 complement(5489330..5489869) 1 NC_002655.2 This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'; primosomal protein DnaI 5489869 dnaT 959691 dnaT Escherichia coli O157:H7 str. EDL933 primosomal protein DnaI NP_290978.1 5489330 R 155864 CDS NP_290979.2 228979039 959690 complement(5489976..5490449) 1 NC_002655.2 hypothetical protein 5490449 yjjB 959690 yjjB Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290979.2 5489976 R 155864 CDS NP_290980.1 15804938 959689 complement(5490440..5491273) 1 NC_002655.2 structural protein 5491273 yjjP 959689 yjjP Escherichia coli O157:H7 str. EDL933 structural protein NP_290980.1 5490440 R 155864 CDS NP_290981.1 15804939 959688 5491831..5492556 1 NC_002655.2 regulator 5492556 yjjQ 959688 yjjQ Escherichia coli O157:H7 str. EDL933 regulator NP_290981.1 5491831 D 155864 CDS NP_290982.2 161367451 959687 5492568..5493191 1 NC_002655.2 regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin; DNA-binding transcriptional activator BglJ 5493191 bglJ 959687 bglJ Escherichia coli O157:H7 str. EDL933 DNA-binding transcriptional activator BglJ NP_290982.2 5492568 D 155864 CDS NP_290983.1 15804941 959686 complement(5493229..5494017) 1 NC_002655.2 ferric hydroximate transport ferric iron reductase 5494017 fhuF 959686 fhuF Escherichia coli O157:H7 str. EDL933 ferric hydroximate transport ferric iron reductase NP_290983.1 5493229 R 155864 CDS NP_290984.1 15804942 959684 complement(5494709..5495740) 1 NC_002655.2 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase 5495740 rsmC 959684 rsmC Escherichia coli O157:H7 str. EDL933 16S ribosomal RNA m2G1207 methyltransferase NP_290984.1 5494709 R 155864 CDS NP_290985.1 15804943 959683 5495843..5496256 1 NC_002655.2 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 5496256 holD 959683 holD Escherichia coli O157:H7 str. EDL933 DNA polymerase III subunit psi NP_290985.1 5495843 D 155864 CDS NP_290986.1 15804944 959682 5496225..5496671 1 NC_002655.2 alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 5496671 rimI 959682 rimI Escherichia coli O157:H7 str. EDL933 ribosomal-protein-alanine N-acetyltransferase NP_290986.1 5496225 D 155864 CDS NP_290987.1 15804945 959681 5496686..5497363 1 NC_002655.2 manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily; nucleotidase 5497363 yjjG 959681 yjjG Escherichia coli O157:H7 str. EDL933 nucleotidase NP_290987.1 5496686 D 155864 CDS NP_290988.1 15804946 959680 5497454..5499043 1 NC_002655.2 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 5499043 prfC 959680 prfC Escherichia coli O157:H7 str. EDL933 peptide chain release factor 3 NP_290988.1 5497454 D 155864 CDS NP_290989.1 15804947 959679 5499436..5500041 1 NC_002655.2 hypothetical protein 5500041 osmY 959679 osmY Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290989.1 5499436 D 155864 CDS NP_290990.1 15804948 959678 5500150..5500329 1 NC_002655.2 No significant matches; hypothetical protein 5500329 959678 Z5978 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290990.1 5500150 D 155864 CDS NP_290991.1 15804949 959677 5500451..5501524 1 NC_002655.2 hypothetical protein 5501524 yjjU 959677 yjjU Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290991.1 5500451 D 155864 CDS NP_290992.1 15804950 959676 5501665..5502348 1 NC_002655.2 hypothetical protein 5502348 yjjV 959676 yjjV Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290992.1 5501665 D 155864 CDS NP_290993.1 15804951 959675 complement(5502516..5503379) 1 NC_002655.2 activating enzyme 5503379 yjjW 959675 yjjW Escherichia coli O157:H7 str. EDL933 activating enzyme NP_290993.1 5502516 R 155864 CDS NP_290994.1 15804952 959674 complement(5503351..5504901) 1 NC_002655.2 hypothetical protein 5504901 yjjI 959674 yjjI Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290994.1 5503351 R 155864 CDS NP_290995.1 15804953 959673 5505159..5505938 1 NC_002655.2 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 5505938 deoC 959673 deoC Escherichia coli O157:H7 str. EDL933 deoxyribose-phosphate aldolase NP_290995.1 5505159 D 155864 CDS NP_290996.1 15804954 959672 5506065..5507387 1 NC_002655.2 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 5507387 deoA 959672 deoA Escherichia coli O157:H7 str. EDL933 thymidine phosphorylase NP_290996.1 5506065 D 155864 CDS NP_290997.1 15804955 959671 5507439..5508662 1 NC_002655.2 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 5508662 deoB 959671 deoB Escherichia coli O157:H7 str. EDL933 phosphopentomutase NP_290997.1 5507439 D 155864 CDS NP_290998.1 15804956 959670 5508719..5509438 1 NC_002655.2 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 5509438 deoD 959670 deoD Escherichia coli O157:H7 str. EDL933 purine nucleoside phosphorylase NP_290998.1 5508719 D 155864 CDS NP_290999.1 15804957 959669 complement(5509599..5509862) 1 NC_002655.2 No significant matches; hypothetical protein 5509862 959669 Z5987 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_290999.1 5509599 R 155864 CDS NP_291000.1 15804958 959668 complement(5509894..5511582) 1 NC_002655.2 in E. coli the lipoate ligase A catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes; creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins; hypothetical protein 5511582 959668 Z5988 Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_291000.1 5509894 R 155864 CDS NP_291001.1 15804959 959667 5511688..5512656 1 NC_002655.2 catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase 5512656 serB 959667 serB Escherichia coli O157:H7 str. EDL933 phosphoserine phosphatase NP_291001.1 5511688 D 155864 CDS NP_291002.1 15804960 959666 5512705..5514087 1 NC_002655.2 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 5514087 sms 959666 sms Escherichia coli O157:H7 str. EDL933 DNA repair protein RadA NP_291002.1 5512705 D 155864 CDS NP_291003.2 161367450 959665 5514108..5515340 1 NC_002655.2 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase 5515340 nadR 959665 nadR Escherichia coli O157:H7 str. EDL933 nicotinamide-nucleotide adenylyltransferase NP_291003.2 5514108 D 155864 CDS NP_291004.1 15804962 959664 complement(5515648..5517315) 1 NC_002655.2 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein 5517315 yjjK 959664 yjjK Escherichia coli O157:H7 str. EDL933 ABC transporter ATP-binding protein NP_291004.1 5515648 R 155864 CDS NP_291005.2 161367449 959663 5517526..5519463 1 NC_002655.2 catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan; lytic murein transglycosylase 5519463 slt 959663 slt Escherichia coli O157:H7 str. EDL933 lytic murein transglycosylase NP_291005.2 5517526 D 155864 CDS NP_291006.1 15804964 959662 5519553..5519879 1 NC_002655.2 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 5519879 trpR 959662 trpR Escherichia coli O157:H7 str. EDL933 Trp operon repressor NP_291006.1 5519553 D 155864 CDS NP_291007.2 161367448 959661 complement(5520026..5520538) 1 NC_002655.2 pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog; NTPase 5520538 yjjX 959661 yjjX Escherichia coli O157:H7 str. EDL933 NTPase NP_291007.2 5520026 R 155864 CDS NP_291008.1 15804966 959660 5520590..5521237 1 NC_002655.2 catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate; phosphoglycerate mutase 5521237 gpmB 959660 gpmB Escherichia coli O157:H7 str. EDL933 phosphoglycerate mutase NP_291008.1 5520590 D 155864 CDS NP_291009.1 15804967 959659 complement(5521234..5522103) 1 NC_002655.2 right origin-binding protein 5522103 rob 959659 rob Escherichia coli O157:H7 str. EDL933 right origin-binding protein NP_291009.1 5521234 R 155864 CDS NP_291010.1 15804968 959658 5522314..5522787 1 NC_002655.2 hypothetical protein 5522787 creA 959658 creA Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_291010.1 5522314 D 155864 CDS NP_291011.1 15804969 959657 5522800..5523489 1 NC_002655.2 response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation; DNA-binding response regulator CreB 5523489 creB 959657 creB Escherichia coli O157:H7 str. EDL933 DNA-binding response regulator CreB NP_291011.1 5522800 D 155864 CDS NP_291012.1 15804970 959656 5523489..5524913 1 NC_002655.2 part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation; sensory histidine kinase CreC 5524913 creC 959656 creC Escherichia coli O157:H7 str. EDL933 sensory histidine kinase CreC NP_291012.1 5523489 D 155864 CDS NP_291013.1 15804971 959655 5524971..5526323 1 NC_002655.2 hypothetical protein 5526323 creD 959655 creD Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_291013.1 5524971 D 155864 CDS NP_291014.1 15804972 959654 complement(5526383..5527099) 1 NC_002655.2 two-component response regulator 5527099 arcA 959654 arcA Escherichia coli O157:H7 str. EDL933 two-component response regulator NP_291014.1 5526383 R 155864 CDS NP_291015.1 15804973 959653 5527195..5527335 1 NC_002655.2 hypothetical protein 5527335 yjjY 959653 yjjY Escherichia coli O157:H7 str. EDL933 hypothetical protein NP_291015.1 5527195 D 155864 CDS NP_291016.1 15804974 959652 5527735..5528421 1 NC_002655.2 member of the SPOUT superfamily of methyltransferases; RNA methyltransferase 5528421 lasT 959652 lasT Escherichia coli O157:H7 str. EDL933 RNA methyltransferase NP_291016.1 5527735 D 155864 CDS YP_325561.1 75994448 3683668 1..561 1 NC_007414.1 conjugal transfer repressor; 97 pct identical amino acid sequence and equal length to FIO1_ECOLI SW: P22707; conjugal transfer fertility inhibition protein FinO 561 finO 3683668 finO Escherichia coli O157:H7 str. EDL933 conjugal transfer fertility inhibition protein FinO YP_325561.1 1 D 155864 CDS YP_325562.1 75994449 3683669 698..949 1 NC_007414.1 54 pct identical (1 gap) to 23 residues of an approx. 269 aa protein EXOK_RHIME SW: P33693; hypothetical protein 949 3683669 L7002 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325562.1 698 D 155864 CDS YP_325563.1 75994450 3683670 1151..1612 1 NC_007414.1 15.6 kDa protein in finO 3' region precursor; 98 pct identical and equal length to YFI3_ECOLI SW: Q99342; hypothetical protein 1612 3683670 L7003 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325563.1 1151 D 155864 CDS YP_325564.1 75994451 3683671 1658..1867 1 NC_007414.1 55 pct identical (0 gaps) to 66 residues of an approx. 72 aa protein HHA_ECOLI SW: P23870; putative hemolysin expression-modulating protein 1867 3683671 L7004 Escherichia coli O157:H7 str. EDL933 putative hemolysin expression-modulating protein YP_325564.1 1658 D 155864 CDS YP_325565.1 75994452 3683672 1905..2243 1 NC_007414.1 98 pct identical (0 gaps) to 57 residues of an approx. 200 aa protein; plasmid R100 miniplasmid pSM1 ORF 4, TRSW: Q52340; hypothetical protein 2243 3683672 L7005 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325565.1 1905 D 155864 CDS YP_325566.1 75994453 3683697 2483..2737 1 NC_007414.1 RepA2 protein; 98 pct identical amino acid sequence and equal length to CPB2_ECOLI SW: P03847; replication protein 2737 cpb2 3683697 cpb2 Escherichia coli O157:H7 str. EDL933 replication protein YP_325566.1 2483 D 155864 CDS YP_325567.1 75994454 3683698 2973..3047 1 NC_007414.1 RepA6; leader peptide RepL 3047 3683698 L7007 Escherichia coli O157:H7 str. EDL933 leader peptide RepL YP_325567.1 2973 D 155864 CDS YP_325568.1 75994455 3683699 3040..3897 1 NC_007414.1 RepA; replication protein 3897 rep2 3683699 rep2 Escherichia coli O157:H7 str. EDL933 replication protein YP_325568.1 3040 D 155864 CDS YP_325569.1 75994456 3683700 4259..4453 1 NC_007414.1 95 pct identical to (0 gaps) 64 residues of a 128 aa protein REPA4 locus ECRSC1 accession V00351; replication protein 4453 3683700 L7009 Escherichia coli O157:H7 str. EDL933 replication protein YP_325569.1 4259 D 155864 CDS YP_325570.1 75994457 3683701 4810..5094 1 NC_007414.1 28 pct identical to 67 residues of a 82 aa protein Y4KO_RHISN SW : P55533; hypothetical protein 5094 3683701 L7010 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325570.1 4810 D 155864 CDS YP_325571.1 75994458 3683702 5094..5369 1 NC_007414.1 81 pct identical (1 gaps) to 42 residues of an approx. 42 aa protein ORF2 fragment TRSW Q47652; plasmid stability locus; hypothetical protein 5369 3683702 L7011 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325571.1 5094 D 155864 CDS YP_325572.1 75994459 3683703 complement(5440..5727) 1 NC_007414.1 37 pct identical (2 gaps) to 43 residues of an approx. 675 aa protein COP1_ARATH SW: P43254; hypothetical protein 5727 3683703 L7012 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325572.1 5440 R 155864 CDS YP_325574.1 75994460 3683713 complement(6029..6763) 1 NC_007414.1 98 pct identical to 188 residues of a 272 aa protein YIS2_SHISO SW: P16940; IS600; hypothetical protein 6763 3683713 L7014 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325574.1 6029 R 155864 CDS YP_325575.1 75994461 3683714 complement(6547..7056) 1 NC_007414.1 96 pct identical (0 gaps) to 139 residues of an approx. 426 aa protein transposase of IS91 accession Q47315; transposase 7056 3683714 L7015 Escherichia coli O157:H7 str. EDL933 transposase YP_325575.1 6547 R 155864 CDS YP_325576.1 75994462 3683715 7041..7280 1 NC_007414.1 26 pct identical (1 gaps) to 26 residues of an approx. 1180 aa protein ITA1_RAT SW: P18614; hypothetical protein 7280 3683715 L7016 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325576.1 7041 D 155864 CDS YP_325577.1 75994463 3683716 7373..9583 1 NC_007414.1 100 pct identical to katP ECEHECCTP accession Number X89017; EHEC-catalase/peroxidase 9583 katP 3683716 katP Escherichia coli O157:H7 str. EDL933 EHEC-catalase/peroxidase YP_325577.1 7373 D 155864 CDS YP_325578.1 75994464 3683717 9627..10016 1 NC_007414.1 100 pct identical (0 gaps) and equal length to an unidentified 129 aa protein, accession X97542; hypothetical protein 10016 3683717 L7018 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325578.1 9627 D 155864 CDS YP_325579.1 75994465 3683718 10174..11061 1 NC_007414.1 96 pct identical to 295 residues of a 296 aa protein TRA6_SHISO SW: P16942, IS629 transposase; transposase 11061 3683718 L7019 Escherichia coli O157:H7 str. EDL933 transposase YP_325579.1 10174 D 155864 CDS YP_325580.1 75994466 3683719 11242..15144 1 NC_007414.1 100 pct identical and equal length to a a putative exoprotein-precursor ECDNAPLAS accession X97542; putative exoprotein-precursor 15144 espP 3683719 espP Escherichia coli O157:H7 str. EDL933 putative exoprotein-precursor YP_325580.1 11242 D 155864 CDS YP_325581.1 75994467 3683720 complement(15307..15414) 1 NC_007414.1 42 pct identical (3 gaps) to 35 residues of an approx. 952 aa protein SEN3_YEAST SW: P32565; hypothetical protein 15414 3683720 L7021 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325581.1 15307 R 155864 CDS YP_325582.1 75994468 3683721 complement(15609..15881) 1 NC_007414.1 85 pct identical and equal length to ISA2_SHIDY SW: P03829, IS element iso-IS1N; transposase 15881 insA 3683721 insA Escherichia coli O157:H7 str. EDL933 transposase YP_325582.1 15609 R 155864 CDS YP_325583.1 75994469 3683722 complement(16148..16297) 1 NC_007414.1 85 pct identical (0 gaps) to 46 residues of an approx. 78 aa protein PERD_ECOLI SW:P43476, function unknown; hypothetical protein 16297 3683722 L7023 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325583.1 16148 R 155864 CDS YP_325584.1 75994470 3683723 16587..16721 1 NC_007414.1 49 pct identical (0 gaps) to 43 residues of an approx. 200 aa FIMB_ECOLI SW: P04742; regulatory protein 16721 3683723 L7024 Escherichia coli O157:H7 str. EDL933 regulatory protein YP_325584.1 16587 D 155864 CDS YP_325585.1 75994471 3683724 16882..17055 1 NC_007414.1 44 pct identical (0 gaps) to 23 residues of an approx. 136 aa protein YM33_MARPO SW: P38475; hypothetical protein 17055 3683724 L7025 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325585.1 16882 D 155864 CDS YP_325586.1 75994472 3683725 17323..18144 1 NC_007414.1 70 pct identical (0 gaps) to 102 residues of an approx. 152 aa protein SHF2 SW: P72437; hypothetical protein 18144 3683725 L7026 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325586.1 17323 D 155864 CDS YP_325587.1 75994473 3683726 18147..19250 1 NC_007414.1 32 pct identical (2 gaps) to 164 residues of an approx. 377 aa protein YPJH_BACSU SW: P42982; hypothetical protein 19250 3683726 L7027 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325587.1 18147 D 155864 CDS YP_325588.1 75994474 3683727 19340..21061 1 NC_007414.1 83 pct identical (0 gaps) to 513 residues of an approx. 577 aa protein YIJP_ECOLI SW: P32678; hypothetical protein 21061 3683727 L7028 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325588.1 19340 D 155864 CDS YP_325589.1 75994475 3683728 21102..22133 1 NC_007414.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 22133 3683728 L7029 Escherichia coli O157:H7 str. EDL933 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase YP_325589.1 21102 D 155864 CDS YP_325590.1 75994476 3683729 22421..22594 1 NC_007414.1 32 pct identical (0 gaps) to 57 residues of an approx. 364 aa protein PGLR_COCCA, SW: P26215; hypothetical protein 22594 3683729 L7030 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325590.1 22421 D 155864 CDS YP_325591.1 75994477 3683730 23016..25712 1 NC_007414.1 43 pct identical (17 gaps) to 131 residues of an approx. 904 aa protein TAGA TRSW: Q56595; hypothetical protein 25712 3683730 L7031 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325591.1 23016 D 155864 CDS YP_325592.1 75994478 3683731 25799..26674 1 NC_007414.1 99 pct identical (0 gaps) and equal length to locus ECPO157 accession Y09824; type II secretion protein 26674 etpC 3683731 etpC Escherichia coli O157:H7 str. EDL933 type II secretion protein YP_325592.1 25799 D 155864 CDS YP_325593.1 75994479 3683732 26714..28642 1 NC_007414.1 100 pct identical to locus ECPO157 accession Y09824, alternate start for etpD chosen in Y09824; type II secretion protein 28642 etpD 3683732 etpD Escherichia coli O157:H7 str. EDL933 type II secretion protein YP_325593.1 26714 D 155864 CDS YP_325594.1 75994480 3683733 28642..30147 1 NC_007414.1 99 pct identical (0 gaps) and equal length to locus ECPO157 accession Y09824; type II secretion protein 30147 etpE 3683733 etpE Escherichia coli O157:H7 str. EDL933 type II secretion protein YP_325594.1 28642 D 155864 CDS YP_325595.1 75994481 3683734 30149..31372 1 NC_007414.1 100 pct identical (0 gaps)to locus ECPO157 accession Y09824; type II secretion protein 31372 etpF 3683734 etpF Escherichia coli O157:H7 str. EDL933 type II secretion protein YP_325595.1 30149 D 155864 CDS YP_325596.1 75994482 3683735 31403..31837 1 NC_007414.1 100 pct identical (0 gaps) to locus ECPO157 accession Y09824; type II secretion protein 31837 etpG 3683735 etpG Escherichia coli O157:H7 str. EDL933 type II secretion protein YP_325596.1 31403 D 155864 CDS YP_325597.1 75994483 3683736 31834..32388 1 NC_007414.1 100 pct identical (0 gaps) to locus ECPO157 accession Y09824; type II secretion protein 32388 etpH 3683736 etpH Escherichia coli O157:H7 str. EDL933 type II secretion protein YP_325597.1 31834 D 155864 CDS YP_325598.1 75994484 3683737 32385..32750 1 NC_007414.1 100 pct identical to locus ECPO157 accession Y09824, different start in Y09824; type II secretion protein 32750 etpI 3683737 etpI Escherichia coli O157:H7 str. EDL933 type II secretion protein YP_325598.1 32385 D 155864 CDS YP_325599.1 75994485 3683738 32747..33346 1 NC_007414.1 100 pct identical (0 gaps) to locus ECPO157 accession Y09824; type II secretion protein 33346 etpJ 3683738 etpJ Escherichia coli O157:H7 str. EDL933 type II secretion protein YP_325599.1 32747 D 155864 CDS YP_325600.1 75994486 3683739 33343..34320 1 NC_007414.1 100 pct identical (0 gaps) to locus ECPO157 accession Y09824; type II secretion protein 34320 etpK 3683739 etpK Escherichia coli O157:H7 str. EDL933 type II secretion protein YP_325600.1 33343 D 155864 CDS YP_325601.1 75994487 3683740 34254..35531 1 NC_007414.1 100 pct identical (0 gaps) to locus ECPO157 accession Y09824, alternate start in Y09824; type II secretion protein 35531 etpL 3683740 etpL Escherichia coli O157:H7 str. EDL933 type II secretion protein YP_325601.1 34254 D 155864 CDS YP_325602.1 75994488 3683741 35518..36030 1 NC_007414.1 100 pct identical (0 gaps) to locus ECPO157 accession Y09824; type II secretion protein 36030 etpM 3683741 etpM Escherichia coli O157:H7 str. EDL933 type II secretion protein YP_325602.1 35518 D 155864 CDS YP_325603.1 75994489 3683742 36088..36921 1 NC_007414.1 100 pct identical (0 gaps) to locus ECPO157 accession Y09824, alternate start in Y09824; type II secretion protein 36921 etpN 3683742 etpN Escherichia coli O157:H7 str. EDL933 type II secretion protein YP_325603.1 36088 D 155864 CDS YP_325604.1 75994490 3683743 37013..37414 1 NC_007414.1 100 pct identical (0 gaps) to locus ECPO157 accession Y09824; type II secretion protein 37414 etpO 3683743 etpO Escherichia coli O157:H7 str. EDL933 type II secretion protein YP_325604.1 37013 D 155864 CDS YP_325605.1 75994491 3683744 37557..37898 1 NC_007414.1 97 pct identical (1 gaps) to 112 residues of an approx. 112 aa protein YI91_SHIDY SW: P39213, IS911; hypothetical protein 37898 3683744 L7045 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325605.1 37557 D 155864 CDS YP_325606.1 75994492 3683745 37943..38764 1 NC_007414.1 IS911; ORFB; 91 pct identical (0 gaps) to 265 residues of an approx. 267 aa protein SDIS911, accession X17613; hypothetical protein 38764 3683745 L7046 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325606.1 37943 D 155864 CDS YP_325607.1 75994493 3683746 39305..39820 1 NC_007414.1 99 pct identical (0 gaps) to 168 residues of an 168 aa protein EHEC-hlyC TRSW: Q47460, alternate start in Q47460; hemolysin transport protein 39820 EHEC-hlyC 3683746 EHEC-hlyC Escherichia coli O157:H7 str. EDL933 hemolysin transport protein YP_325607.1 39305 D 155864 CDS YP_325608.1 75994494 3683747 39822..42818 1 NC_007414.1 99 pct identical (0 gaps) and equal length to a protein EHEC-hlyA TRSW: Q47461; hemolysin toxin protein 42818 EHEC-hlyA 3683747 EHEC-hlyA Escherichia coli O157:H7 str. EDL933 hemolysin toxin protein YP_325608.1 39822 D 155864 CDS YP_325609.1 75994495 3683748 42868..44988 1 NC_007414.1 99 pct identical and equal length to EHEC-hlyB TRSW: Q47462; hemolysin transport protein 44988 EHEC-hlyB 3683748 EHEC-hlyB Escherichia coli O157:H7 str. EDL933 hemolysin transport protein YP_325609.1 42868 D 155864 CDS YP_325610.1 75994496 3683705 44992..46431 1 NC_007414.1 99 pct identical and equal length to EHEC-hlyD TRSW: Q47463; hemolysin transport protein 46431 EHEC-hlyD 3683705 EHEC-hlyD Escherichia coli O157:H7 str. EDL933 hemolysin transport protein YP_325610.1 44992 D 155864 CDS YP_325611.1 75994497 3683706 46498..46692 1 NC_007414.1 49 pct identical (0 gaps) to 41 residues of an approx.164 aa protein PAPX_ECOLI SW: P42193; hypothetical protein 46692 3683706 L7051 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325611.1 46498 D 155864 CDS YP_325612.1 75994498 3683707 46722..47006 1 NC_007414.1 52 pct identical (0 gaps) to 79 residues of an approx. 164 aa protein PAPX_ECOLI SW: P42193; hypothetical protein 47006 3683707 L7052 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325612.1 46722 D 155864 CDS YP_325613.1 75994499 3683708 47175..47405 1 NC_007414.1 47 pct identical (1 gaps) to 32 residues of an approx. 1240 aa protein R31240_1 TRSW: O00114; putative serine-threonine protein kinase 47405 3683708 L7053 Escherichia coli O157:H7 str. EDL933 putative serine-threonine protein kinase YP_325613.1 47175 D 155864 CDS YP_325614.1 75994500 3683709 47910..48266 1 NC_007414.1 100 pct identical and equal length to a 118 aa protein 'ORF3' locus FPLREPFIB accession M26308; replication protein 48266 3683709 L7054 Escherichia coli O157:H7 str. EDL933 replication protein YP_325614.1 47910 D 155864 CDS YP_325615.1 75994501 3683710 complement(47955..48272) 1 NC_007414.1 96 pct identical and equal length to a 105 aa protein 'ORF5' locus FPLREPFIB accession M26308; replication protein 48272 3683710 L7055 Escherichia coli O157:H7 str. EDL933 replication protein YP_325615.1 47955 R 155864 CDS YP_325616.2 161367664 3683711 complement(48551..49528) 1 NC_007414.1 99 pct identical and equal length to a 317 aa protein 'ORF1' locus FPLREPFIB accession M26308; replication protein 49528 3683711 L7056 Escherichia coli O157:H7 str. EDL933 replication protein YP_325616.2 48551 R 155864 CDS YP_325617.1 75994503 3683712 49266..49595 1 NC_007414.1 100 pct identical and equal length to a 109 aa protein 'ORF4' locus FPLREPFIB accession M26308; replication protein 49595 3683712 L7057 Escherichia coli O157:H7 str. EDL933 replication protein YP_325617.1 49266 D 155864 CDS YP_325618.1 75994504 3683687 complement(49936..50172) 1 NC_007414.1 32 pct identical (3 gaps) to 51 residues of an approx. 360 aa protein RECA_BRUAB SW: Q04761; hypothetical protein 50172 3683687 L7058 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325618.1 49936 R 155864 CDS YP_325619.1 75994505 3683688 complement(50133..50753) 1 NC_007414.1 23 pct identical (4 gaps) to 111 residues of an approx. 247 aa protein LANP_RAT SW: P49911; hypothetical protein 50753 3683688 L7059 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325619.1 50133 R 155864 CDS YP_325620.1 75994506 3683689 complement(50750..51433) 1 NC_007414.1 31 pct identical (8 gaps) to 179 residues of an approx. 344 aa protein KFRA TRSW: P71173; hypothetical protein 51433 3683689 L7060 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325620.1 50750 R 155864 CDS YP_325621.1 75994507 3683690 51489..51683 1 NC_007414.1 37 pct identical (0 gaps) to 30 residues of an approx. 680 aa protein PIRA7 accession U96688; hypothetical protein 51683 3683690 L7061 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325621.1 51489 D 155864 CDS YP_325622.1 75994508 3683691 51892..52110 1 NC_007414.1 90 pct identical amino acid sequence and equal length to ECU51588 accession U51588; plasmid maintenance protein CcdA 52110 ccdA 3683691 ccdA Escherichia coli O157:H7 str. EDL933 plasmid maintenance protein CcdA YP_325622.1 51892 D 155864 CDS YP_325623.1 75994509 3683692 52112..52417 1 NC_007414.1 controlled cell death protein; post-segregation toxin; toxin addiction system; plasmid maintenance protein CcdB 52417 ccdB 3683692 ccdB Escherichia coli O157:H7 str. EDL933 plasmid maintenance protein CcdB YP_325623.1 52112 D 155864 CDS YP_325624.1 75994510 3683693 52418..53224 1 NC_007414.1 protein D; 98 pct identical amino acid sequence and equal length to REDF_ECOLI SW: P06615; resolvase 53224 redF 3683693 redF Escherichia coli O157:H7 str. EDL933 resolvase YP_325624.1 52418 D 155864 CDS YP_325625.1 75994511 3683694 complement(53311..54201) 1 NC_007414.1 97 pct identical amino acid sequence and equal length to TRA6_SHISO SW: P16942, IS629; transposase 54201 tra6 3683694 tra6 Escherichia coli O157:H7 str. EDL933 transposase YP_325625.1 53311 R 155864 CDS YP_325626.1 75994512 3683695 complement(54198..54524) 1 NC_007414.1 100 pct identical to YIS3_SHISO SW: P16941, an IS629 protein; hypothetical protein 54524 3683695 L7066 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325626.1 54198 R 155864 CDS YP_325627.1 75994513 3683696 54669..54824 1 NC_007414.1 100 pct identical to a 51 aa protein of approx. 251 aa protein E1_ECOLI, TRSW: P03856; rep protein E1 54824 3683696 L7067 Escherichia coli O157:H7 str. EDL933 rep protein E1 YP_325627.1 54669 D 155864 CDS YP_325628.1 75994514 3683673 55412..56578 1 NC_007414.1 100 pct identical amino acid sequence and equal length to SOPA_ECOLI SW: P08866; plasmid-partitioning protein SopA 56578 sopA 3683673 sopA Escherichia coli O157:H7 str. EDL933 plasmid-partitioning protein SopA YP_325628.1 55412 D 155864 CDS YP_325629.1 75994515 3683674 56578..57549 1 NC_007414.1 SopB; plasmid-partitioning protein 57549 sopB 3683674 sopB Escherichia coli O157:H7 str. EDL933 plasmid-partitioning protein YP_325629.1 56578 D 155864 CDS YP_325630.1 75994516 3683675 57934..58206 1 NC_007414.1 100 pct identical to 25 residues of a 79 aa protein YPF8_ECOLI SW: P08868; hypothetical protein 58206 3683675 L7070 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325630.1 57934 D 155864 CDS YP_325631.1 75994517 3683676 complement(58290..58586) 1 NC_007414.1 36 pct identical (4 gaps) to 47 residues of an approx. 616 aa protein VE1_HPV1A SW: P03111; hypothetical protein 58586 3683676 L7071 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325631.1 58290 R 155864 CDS YP_325632.1 75994518 3683677 58849..60573 1 NC_007414.1 29 pct identical (21 gaps) to 521 residues of an approx. 608 aa protein RDPO_SCEOB SW: P19593; hypothetical protein 60573 3683677 L7072 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325632.1 58849 D 155864 CDS YP_325633.1 75994519 3683678 60650..61552 1 NC_007414.1 25 pct identical (21 gaps) to 126 residues of an approx. 160 aa protein CR18_ORYSA SW: Q06397; hypothetical protein 61552 3683678 L7073 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325633.1 60650 D 155864 CDS YP_325634.1 75994520 3683679 61938..62621 1 NC_007414.1 33 pct identical (14 gaps) to 204 residues of an approx. 232 aa TRSW: Q56638; putative methylase 62621 3683679 L7074 Escherichia coli O157:H7 str. EDL933 putative methylase YP_325634.1 61938 D 155864 CDS YP_325635.1 75994521 3683680 62737..63291 1 NC_007414.1 28 pct identical (3 gaps) to 101 residues of an approx. 184 aa protein X169_CRIGR SW: P41228; hypothetical protein 63291 3683680 L7075 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325635.1 62737 D 155864 CDS YP_325636.1 75994522 3683681 63337..64113 1 NC_007414.1 31 pct identical (2 gaps) to 60 residues of an approx. 480 aa protein VL2_HPV29 SW: P50800; hypothetical protein 64113 3683681 L7076 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325636.1 63337 D 155864 CDS YP_325637.1 75994523 3683682 64531..64956 1 NC_007414.1 36 pct identical (6 gaps) to 137 residues of an approx. 142 aa protein KLA1_ECOLI SW: P52602; hypothetical protein 64956 3683682 L7077 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325637.1 64531 D 155864 CDS YP_325638.1 75994524 3683683 65003..65425 1 NC_007414.1 25 pct identical (4 gaps) to 109 residues of an approx. 1976 aa protein MYSA_CAEEL SW: P12844; hypothetical protein 65425 3683683 L7078 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325638.1 65003 D 155864 CDS YP_325639.1 75994525 3683684 complement(65583..66113) 1 NC_007414.1 20 pct identical (2 gaps) to 96 residues of a 271 aa protein YG5W_YEAST SW: P53335; hypothetical protein 66113 3683684 L7079 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325639.1 65583 R 155864 CDS YP_325640.1 75994526 3683685 complement(66627..66887) 1 NC_007414.1 40 pct identical (1 gaps) to 42 residues of a 1051 aa protein EVI1_HUMAN SW: Q03112; hypothetical protein 66887 3683685 L7080 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325640.1 66627 R 155864 CDS YP_325641.1 75994527 3683686 66891..68252 1 NC_007414.1 27 pct identical to 67 residues of a 296 aa protein FIMP TRSW: Q46527; hypothetical protein 68252 3683686 L7081 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325641.1 66891 D 155864 CDS YP_325642.1 75994528 3683655 68299..68862 1 NC_007414.1 29 pct identical (3 gaps) to 139 residues of a 311 aa protein MYRB_MICGR SW: P43433; hypothetical protein 68862 3683655 L7082 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325642.1 68299 D 155864 CDS YP_325643.1 75994529 3683656 complement(68948..69403) 1 NC_007414.1 25 pct identical (1 gaps) to 106 residues of a 1807 aa protein VTA2_XENLA SW: P18709; hypothetical protein 69403 3683656 L7083 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325643.1 68948 R 155864 CDS YP_325644.1 75994530 3683657 69666..70157 1 NC_007414.1 95 pct identical (0 gaps) to 141 residues of a 179 aa protein SSBF_ECOLI SW: P18310; single-stranded DNA-binding protein 70157 ssb 3683657 ssb Escherichia coli O157:H7 str. EDL933 single-stranded DNA-binding protein YP_325644.1 69666 D 155864 CDS YP_325645.1 75994531 3683658 70187..70447 1 NC_007414.1 57 pct identical (1 gaps) to 65 residues of a 80 aa protein TRSW: P75677; hypothetical protein 70447 3683658 L7085 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325645.1 70187 D 155864 CDS YP_325646.2 161367665 3683659 70513..72471 1 NC_007414.1 99 pct identical (0 gaps) and equal length to a 83 aa protein, putative ORF1 TRSW: P96030; hypothetical protein 72471 3683659 L7086 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325646.2 70513 D 155864 CDS YP_325647.1 75994533 3683660 72523..72960 1 NC_007414.1 97 pct identical amino acid sequence and equal length to PSB1_ECOLI SW: P10031; plasmid SOS inhibition protein B 72960 psiB 3683660 psiB Escherichia coli O157:H7 str. EDL933 plasmid SOS inhibition protein B YP_325647.1 72523 D 155864 CDS YP_325648.1 75994534 3683661 72957..73718 1 NC_007414.1 PsiA; plasmid SOS inhibition protein A 73718 psiA 3683661 psiA Escherichia coli O157:H7 str. EDL933 plasmid SOS inhibition protein A YP_325648.1 72957 D 155864 CDS YP_325649.1 75994535 3683663 73892..74104 1 NC_007414.1 Mok; similar to F leading maintenance protein C; modulator of post-segregation killing protein 74104 flmC 3683663 flmC Escherichia coli O157:H7 str. EDL933 modulator of post-segregation killing protein YP_325649.1 73892 D 155864 CDS YP_325650.1 75994536 3683664 73950..74108 1 NC_007414.1 100 pct identical and equal length to an 52 aa protein FLMA_ECOLI, SW: P16077; small toxic polypeptide 74108 flmA 3683664 flmA Escherichia coli O157:H7 str. EDL933 small toxic polypeptide YP_325650.1 73950 D 155864 CDS YP_325651.1 75994537 3683665 74290..76263 1 NC_007414.1 70 pct identical (3 gaps) to 655 residues of an approx. 904 aa protein Q52336 TRSW: Q52336; putative nickase 76263 3683665 L7091 Escherichia coli O157:H7 str. EDL933 putative nickase YP_325651.1 74290 D 155864 CDS YP_325652.1 75994538 3683666 76331..76762 1 NC_007414.1 34 pct identical (0 gaps) to 77 residues of an approx. 421 aa protein TOLA_ECOLI SW: P19934; hypothetical protein 76762 3683666 L7092 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325652.1 76331 D 155864 CDS YP_325653.1 75994539 3683667 complement(77322..77681) 1 NC_007414.1 77 pct identical (1 gaps) to 91 residues of an approx. 288 aa protein TRA5_ECOLI SW: P05822, IS3; putative transposase 77681 3683667 L7093 Escherichia coli O157:H7 str. EDL933 putative transposase YP_325653.1 77322 R 155864 CDS YP_325654.1 75994540 3683648 77863..78273 1 NC_007414.1 70 pct identical (3 gaps) to 120 residues of an approx. 390 aa protein ISTA_ECOLI SW: P15025, IS21; transposase 78273 3683648 L7094 Escherichia coli O157:H7 str. EDL933 transposase YP_325654.1 77863 D 155864 CDS YP_325655.1 75994541 3683649 78542..88051 1 NC_007414.1 22 pct identical (44 gaps) to 444 residues of an approx. 2364 aa protein Clostridium sordellii cytotoxin L TRSW: Q46342; putative cytotoxin 88051 3683649 L7095 Escherichia coli O157:H7 str. EDL933 putative cytotoxin YP_325655.1 78542 D 155864 CDS YP_325656.1 75994542 3683650 88143..88415 1 NC_007414.1 85 pct identical (0 gaps) to 68 residues of an approx. 288 aa protein TRA5_ECOLI SW: P05822, IS3; putative transposase 88415 3683650 L7096 Escherichia coli O157:H7 str. EDL933 putative transposase YP_325656.1 88143 D 155864 CDS YP_325657.1 75994543 3683651 complement(88342..88845) 1 NC_007414.1 96 pct identical (0 gaps) to 84 residues of an approx. 108 aa protein YIS3_SHISO SW: P16941, IS629; hypothetical protein 88845 3683651 L7097 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325657.1 88342 R 155864 CDS YP_325658.1 75994544 3683652 88992..90290 1 NC_007414.1 96 pct identical to 432 residues of a 1756 aa protein TRI1_ECOLI SW: P14565, truncated by insertion of IS629; DNA helicase 90290 traI 3683652 traI Escherichia coli O157:H7 str. EDL933 DNA helicase YP_325658.1 88992 D 155864 CDS YP_325659.1 75994545 3683653 90310..91056 1 NC_007414.1 94 pct identical and equal length to TRX1_ECOLI SW: P22709; conjugal transfer pilus acetylation protein TraX 91056 traX 3683653 traX Escherichia coli O157:H7 str. EDL933 conjugal transfer pilus acetylation protein TraX YP_325659.1 90310 D 155864 CDS YP_325660.1 75994546 3683654 91115..91975 1 NC_007414.1 31.7 kDa protein in traX-finO intergenic region; 96 pct identical amino acid sequence and equal length to YPT2_ECOLI SW: Q99390; hypothetical protein 91975 ypt2 3683654 ypt2 Escherichia coli O157:H7 str. EDL933 hypothetical protein YP_325660.1 91115 D 155864 CDS