-- dump date 20140619_051639
-- class Genbank::misc_feature
-- table misc_feature_note
-- id note
340322000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
340322000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340322000003 Walker A motif; other site
340322000004 ATP binding site [chemical binding]; other site
340322000005 Walker B motif; other site
340322000006 arginine finger; other site
340322000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
340322000008 DnaA box-binding interface [nucleotide binding]; other site
340322000009 DNA polymerase III subunit beta; Validated; Region: PRK07761
340322000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
340322000011 putative DNA binding surface [nucleotide binding]; other site
340322000012 dimer interface [polypeptide binding]; other site
340322000013 beta-clamp/clamp loader binding surface; other site
340322000014 beta-clamp/translesion DNA polymerase binding surface; other site
340322000015 recombination protein F; Reviewed; Region: recF; PRK00064
340322000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
340322000017 Walker A/P-loop; other site
340322000018 ATP binding site [chemical binding]; other site
340322000019 Q-loop/lid; other site
340322000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322000021 ABC transporter signature motif; other site
340322000022 Walker B; other site
340322000023 D-loop; other site
340322000024 H-loop/switch region; other site
340322000025 hypothetical protein; Provisional; Region: PRK00111
340322000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
340322000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
340322000028 ATP binding site [chemical binding]; other site
340322000029 Mg2+ binding site [ion binding]; other site
340322000030 G-X-G motif; other site
340322000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
340322000032 anchoring element; other site
340322000033 dimer interface [polypeptide binding]; other site
340322000034 ATP binding site [chemical binding]; other site
340322000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
340322000036 active site
340322000037 putative metal-binding site [ion binding]; other site
340322000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
340322000039 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
340322000040 Predicted membrane protein [Function unknown]; Region: COG2364
340322000041 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
340322000042 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
340322000043 DNA gyrase subunit A; Validated; Region: PRK05560
340322000044 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
340322000045 CAP-like domain; other site
340322000046 active site
340322000047 primary dimer interface [polypeptide binding]; other site
340322000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
340322000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
340322000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
340322000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
340322000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
340322000053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
340322000054 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
340322000055 Amino acid permease; Region: AA_permease; pfam00324
340322000056 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
340322000057 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
340322000058 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
340322000059 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
340322000060 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
340322000061 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
340322000062 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
340322000063 NAD(P) binding site [chemical binding]; other site
340322000064 catalytic residues [active]
340322000065 Predicted membrane protein [Function unknown]; Region: COG2855
340322000066 Transcriptional regulator [Transcription]; Region: LysR; COG0583
340322000067 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
340322000068 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
340322000069 dimerization interface [polypeptide binding]; other site
340322000070 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
340322000071 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
340322000072 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
340322000073 DSBA-like thioredoxin domain; Region: DSBA; pfam01323
340322000074 Penicillinase repressor; Region: Pencillinase_R; pfam03965
340322000075 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
340322000076 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
340322000077 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
340322000078 active site
340322000079 metal binding site [ion binding]; metal-binding site
340322000080 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
340322000081 Protein of unknown function (DUF418); Region: DUF418; cl12135
340322000082 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
340322000083 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
340322000084 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
340322000085 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
340322000086 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
340322000087 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
340322000088 putative active site [active]
340322000089 putative metal binding site [ion binding]; other site
340322000090 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
340322000091 putative ADP-binding pocket [chemical binding]; other site
340322000092 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
340322000093 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
340322000094 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
340322000095 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
340322000096 Bacterial sugar transferase; Region: Bac_transf; pfam02397
340322000097 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
340322000098 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
340322000099 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
340322000100 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
340322000101 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
340322000102 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
340322000103 Divergent AAA domain; Region: AAA_4; pfam04326
340322000104 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
340322000105 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
340322000106 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
340322000107 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
340322000108 intersubunit interface [polypeptide binding]; other site
340322000109 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
340322000110 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
340322000111 ABC-ATPase subunit interface; other site
340322000112 dimer interface [polypeptide binding]; other site
340322000113 putative PBP binding regions; other site
340322000114 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
340322000115 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322000116 Walker A/P-loop; other site
340322000117 ATP binding site [chemical binding]; other site
340322000118 Q-loop/lid; other site
340322000119 ABC transporter signature motif; other site
340322000120 Walker B; other site
340322000121 D-loop; other site
340322000122 H-loop/switch region; other site
340322000123 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
340322000124 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
340322000125 putative ligand binding site [chemical binding]; other site
340322000126 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
340322000127 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
340322000128 TM-ABC transporter signature motif; other site
340322000129 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
340322000130 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
340322000131 Walker A/P-loop; other site
340322000132 ATP binding site [chemical binding]; other site
340322000133 Q-loop/lid; other site
340322000134 ABC transporter signature motif; other site
340322000135 Walker B; other site
340322000136 D-loop; other site
340322000137 H-loop/switch region; other site
340322000138 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
340322000139 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
340322000140 active site
340322000141 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
340322000142 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
340322000143 Helix-turn-helix domain; Region: HTH_18; pfam12833
340322000144 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
340322000145 putative septation inhibitor protein; Reviewed; Region: PRK00159
340322000146 Protein Kinases, catalytic domain; Region: PKc_like; cl09925
340322000147 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
340322000148 active site
340322000149 ATP binding site [chemical binding]; other site
340322000150 substrate binding site [chemical binding]; other site
340322000151 activation loop (A-loop); other site
340322000152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
340322000153 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
340322000154 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
340322000155 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
340322000156 PASTA domain; Region: PASTA; pfam03793
340322000157 Protein Kinases, catalytic domain; Region: PKc_like; cl09925
340322000158 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
340322000159 active site
340322000160 ATP binding site [chemical binding]; other site
340322000161 substrate binding site [chemical binding]; other site
340322000162 activation loop (A-loop); other site
340322000163 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
340322000164 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
340322000165 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
340322000166 Protein phosphatase 2C; Region: PP2C; pfam00481
340322000167 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
340322000168 active site
340322000169 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
340322000170 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
340322000171 phosphopeptide binding site; other site
340322000172 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
340322000173 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
340322000174 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
340322000175 phosphopeptide binding site; other site
340322000176 putative succinate dehydrogenase; Reviewed; Region: PRK12842
340322000177 metabolite-proton symporter; Region: 2A0106; TIGR00883
340322000178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322000179 putative substrate translocation pore; other site
340322000180 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
340322000181 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844
340322000182 Predicted oxidoreductase [General function prediction only]; Region: COG3573
340322000183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
340322000184 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
340322000185 NAD(P) binding site [chemical binding]; other site
340322000186 active site
340322000187 Transcriptional regulator [Transcription]; Region: IclR; COG1414
340322000188 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
340322000189 putative DNA binding site [nucleotide binding]; other site
340322000190 putative Zn2+ binding site [ion binding]; other site
340322000191 Bacterial transcriptional regulator; Region: IclR; pfam01614
340322000192 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
340322000193 succinic semialdehyde dehydrogenase; Region: PLN02278
340322000194 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
340322000195 tetramerization interface [polypeptide binding]; other site
340322000196 NAD(P) binding site [chemical binding]; other site
340322000197 catalytic residues [active]
340322000198 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
340322000199 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
340322000200 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
340322000201 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
340322000202 active site residue [active]
340322000203 Sulfite exporter TauE/SafE; Region: TauE; pfam01925
340322000204 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
340322000205 active site residue [active]
340322000206 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
340322000207 active site residue [active]
340322000208 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
340322000209 putative homodimer interface [polypeptide binding]; other site
340322000210 putative homotetramer interface [polypeptide binding]; other site
340322000211 putative allosteric switch controlling residues; other site
340322000212 putative metal binding site [ion binding]; other site
340322000213 putative homodimer-homodimer interface [polypeptide binding]; other site
340322000214 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
340322000215 putative metal binding residues [ion binding]; other site
340322000216 signature motif; other site
340322000217 dimer interface [polypeptide binding]; other site
340322000218 active site
340322000219 polyP binding site; other site
340322000220 substrate binding site [chemical binding]; other site
340322000221 acceptor-phosphate pocket; other site
340322000222 MgtC family; Region: MgtC; pfam02308
340322000223 Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337
340322000224 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
340322000225 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
340322000226 oligomer interface [polypeptide binding]; other site
340322000227 metal binding site [ion binding]; metal-binding site
340322000228 metal binding site [ion binding]; metal-binding site
340322000229 putative Cl binding site [ion binding]; other site
340322000230 basic sphincter; other site
340322000231 hydrophobic gate; other site
340322000232 periplasmic entrance; other site
340322000233 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
340322000234 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
340322000235 dimer interface [polypeptide binding]; other site
340322000236 hexamer interface [polypeptide binding]; other site
340322000237 active site 2 [active]
340322000238 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
340322000239 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
340322000240 putative ion selectivity filter; other site
340322000241 putative pore gating glutamate residue; other site
340322000242 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201
340322000243 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875
340322000244 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
340322000245 putative active site [active]
340322000246 PhoH-like protein; Region: PhoH; pfam02562
340322000247 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
340322000248 Citrate transporter; Region: CitMHS; pfam03600
340322000249 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
340322000250 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
340322000251 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
340322000252 ATP binding site [chemical binding]; other site
340322000253 Mg2+ binding site [ion binding]; other site
340322000254 G-X-G motif; other site
340322000255 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
340322000256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
340322000257 active site
340322000258 phosphorylation site [posttranslational modification]
340322000259 intermolecular recognition site; other site
340322000260 dimerization interface [polypeptide binding]; other site
340322000261 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
340322000262 putative DNA binding site [nucleotide binding]; other site
340322000263 putative Zn2+ binding site [ion binding]; other site
340322000264 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
340322000265 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159
340322000266 putative ligand binding site [chemical binding]; other site
340322000267 putative NAD binding site [chemical binding]; other site
340322000268 catalytic site [active]
340322000269 biotin synthase; Validated; Region: PRK06256
340322000270 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
340322000271 FeS/SAM binding site; other site
340322000272 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
340322000273 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357
340322000274 CHY zinc finger; Region: zf-CHY; pfam05495
340322000275 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
340322000276 cytosine deaminase; Provisional; Region: PRK09230
340322000277 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
340322000278 active site
340322000279 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
340322000280 NAD-dependent deacetylase; Provisional; Region: PRK05333
340322000281 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
340322000282 Lipase (class 2); Region: Lipase_2; pfam01674
340322000283 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
340322000284 Lipase (class 2); Region: Lipase_2; pfam01674
340322000285 Transcriptional regulators [Transcription]; Region: MarR; COG1846
340322000286 Winged helix DNA-binding domain; Region: HTH_27; pfam13463
340322000287 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
340322000288 alpha-gamma subunit interface [polypeptide binding]; other site
340322000289 beta-gamma subunit interface [polypeptide binding]; other site
340322000290 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
340322000291 gamma-beta subunit interface [polypeptide binding]; other site
340322000292 alpha-beta subunit interface [polypeptide binding]; other site
340322000293 urease subunit alpha; Reviewed; Region: ureC; PRK13207
340322000294 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
340322000295 subunit interactions [polypeptide binding]; other site
340322000296 active site
340322000297 flap region; other site
340322000298 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
340322000299 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
340322000300 dimer interface [polypeptide binding]; other site
340322000301 catalytic residues [active]
340322000302 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
340322000303 UreF; Region: UreF; pfam01730
340322000304 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
340322000305 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
340322000306 HSP90 family protein; Provisional; Region: PRK14083
340322000307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
340322000308 ATP binding site [chemical binding]; other site
340322000309 Mg2+ binding site [ion binding]; other site
340322000310 G-X-G motif; other site
340322000311 AMP nucleosidase; Region: AMP-nucleosdse; TIGR01717
340322000312 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
340322000313 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
340322000314 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
340322000315 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
340322000316 NAD binding site [chemical binding]; other site
340322000317 catalytic Zn binding site [ion binding]; other site
340322000318 structural Zn binding site [ion binding]; other site
340322000319 Transcriptional regulators [Transcription]; Region: PurR; COG1609
340322000320 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
340322000321 DNA binding site [nucleotide binding]
340322000322 domain linker motif; other site
340322000323 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
340322000324 dimerization interface [polypeptide binding]; other site
340322000325 ligand binding site [chemical binding]; other site
340322000326 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
340322000327 histidinol dehydrogenase; Region: hisD; TIGR00069
340322000328 NAD binding site [chemical binding]; other site
340322000329 dimerization interface [polypeptide binding]; other site
340322000330 product binding site; other site
340322000331 substrate binding site [chemical binding]; other site
340322000332 zinc binding site [ion binding]; other site
340322000333 catalytic residues [active]
340322000334 Citrate transporter; Region: CitMHS; pfam03600
340322000335 fructuronate transporter; Provisional; Region: PRK10034; cl15264
340322000336 DDE domain; Region: DDE_Tnp_IS240; pfam13610
340322000337 Integrase core domain; Region: rve; pfam00665
340322000338 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
340322000339 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
340322000340 Multicopper oxidase; Region: Cu-oxidase; pfam00394
340322000341 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
340322000342 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
340322000343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
340322000344 active site
340322000345 phosphorylation site [posttranslational modification]
340322000346 intermolecular recognition site; other site
340322000347 dimerization interface [polypeptide binding]; other site
340322000348 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
340322000349 DNA binding site [nucleotide binding]
340322000350 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
340322000351 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
340322000352 dimerization interface [polypeptide binding]; other site
340322000353 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
340322000354 dimer interface [polypeptide binding]; other site
340322000355 phosphorylation site [posttranslational modification]
340322000356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
340322000357 ATP binding site [chemical binding]; other site
340322000358 Mg2+ binding site [ion binding]; other site
340322000359 G-X-G motif; other site
340322000360 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
340322000361 metal-binding site [ion binding]
340322000362 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
340322000363 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
340322000364 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
340322000365 motif I; other site
340322000366 motif II; other site
340322000367 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563
340322000368 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563
340322000369 Transcriptional regulators [Transcription]; Region: Lrp; COG1522
340322000370 AsnC family; Region: AsnC_trans_reg; pfam01037
340322000371 DDE domain; Region: DDE_Tnp_IS240; pfam13610
340322000372 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
340322000373 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
340322000374 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
340322000375 motif II; other site
340322000376 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
340322000377 metal-binding site [ion binding]
340322000378 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
340322000379 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
340322000380 multiple promoter invertase; Provisional; Region: mpi; PRK13413
340322000381 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
340322000382 catalytic residues [active]
340322000383 catalytic nucleophile [active]
340322000384 Presynaptic Site I dimer interface [polypeptide binding]; other site
340322000385 Synaptic Antiparallel dimer interface [polypeptide binding]; other site
340322000386 Synaptic Flat tetramer interface [polypeptide binding]; other site
340322000387 Synaptic Site I dimer interface [polypeptide binding]; other site
340322000388 DNA binding site [nucleotide binding]
340322000389 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
340322000390 DNA-binding interface [nucleotide binding]; DNA binding site
340322000391 DDE superfamily endonuclease; Region: DDE_3; pfam13358
340322000392 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
340322000393 putative active site [active]
340322000394 redox center [active]
340322000395 Thioredoxin; Region: Thioredoxin_4; pfam13462
340322000396 DSBA-like thioredoxin domain; Region: DSBA; pfam01323
340322000397 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
340322000398 dimerization interface [polypeptide binding]; other site
340322000399 putative DNA binding site [nucleotide binding]; other site
340322000400 putative Zn2+ binding site [ion binding]; other site
340322000401 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
340322000402 Peptidase family M23; Region: Peptidase_M23; pfam01551
340322000403 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
340322000404 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
340322000405 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
340322000406 Copper resistance protein D; Region: CopD; pfam05425
340322000407 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
340322000408 CopC domain; Region: CopC; pfam04234
340322000409 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
340322000410 dimerization interface [polypeptide binding]; other site
340322000411 putative DNA binding site [nucleotide binding]; other site
340322000412 putative Zn2+ binding site [ion binding]; other site
340322000413 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
340322000414 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
340322000415 Soluble P-type ATPase [General function prediction only]; Region: COG4087
340322000416 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
340322000417 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
340322000418 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
340322000419 Soluble P-type ATPase [General function prediction only]; Region: COG4087
340322000420 Homeodomain-like domain; Region: HTH_23; pfam13384
340322000421 Winged helix-turn helix; Region: HTH_29; pfam13551
340322000422 Homeodomain-like domain; Region: HTH_32; pfam13565
340322000423 DDE superfamily endonuclease; Region: DDE_3; pfam13358
340322000424 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
340322000425 DDE superfamily endonuclease; Region: DDE_5; cl17874
340322000426 Integrase core domain; Region: rve_3; pfam13683
340322000427 HTH-like domain; Region: HTH_21; pfam13276
340322000428 Integrase core domain; Region: rve; pfam00665
340322000429 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
340322000430 Helix-turn-helix domain; Region: HTH_38; pfam13936
340322000431 Integrase core domain; Region: rve; pfam00665
340322000432 Transposase; Region: HTH_Tnp_1; cl17663
340322000433 Cadmium resistance transporter; Region: Cad; pfam03596
340322000434 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
340322000435 dimerization interface [polypeptide binding]; other site
340322000436 putative DNA binding site [nucleotide binding]; other site
340322000437 putative Zn2+ binding site [ion binding]; other site
340322000438 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
340322000439 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
340322000440 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
340322000441 FeoA domain; Region: FeoA; pfam04023
340322000442 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
340322000443 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
340322000444 multiple promoter invertase; Provisional; Region: mpi; PRK13413
340322000445 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
340322000446 catalytic residues [active]
340322000447 catalytic nucleophile [active]
340322000448 Presynaptic Site I dimer interface [polypeptide binding]; other site
340322000449 Synaptic Antiparallel dimer interface [polypeptide binding]; other site
340322000450 Synaptic Flat tetramer interface [polypeptide binding]; other site
340322000451 Synaptic Site I dimer interface [polypeptide binding]; other site
340322000452 DNA binding site [nucleotide binding]
340322000453 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
340322000454 DNA-binding interface [nucleotide binding]; DNA binding site
340322000455 multiple promoter invertase; Provisional; Region: mpi; PRK13413
340322000456 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
340322000457 catalytic residues [active]
340322000458 catalytic nucleophile [active]
340322000459 Presynaptic Site I dimer interface [polypeptide binding]; other site
340322000460 Synaptic Antiparallel dimer interface [polypeptide binding]; other site
340322000461 Synaptic Flat tetramer interface [polypeptide binding]; other site
340322000462 Synaptic Site I dimer interface [polypeptide binding]; other site
340322000463 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
340322000464 DNA-binding interface [nucleotide binding]; DNA binding site
340322000465 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
340322000466 dimerization interface [polypeptide binding]; other site
340322000467 putative DNA binding site [nucleotide binding]; other site
340322000468 putative Zn2+ binding site [ion binding]; other site
340322000469 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
340322000470 Cadmium resistance transporter; Region: Cad; pfam03596
340322000471 mercuric reductase; Region: MerA; TIGR02053
340322000472 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
340322000473 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
340322000474 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
340322000475 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
340322000476 DNA binding residues [nucleotide binding]
340322000477 dimer interface [polypeptide binding]; other site
340322000478 metal binding site [ion binding]; metal-binding site
340322000479 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340322000480 salt bridge; other site
340322000481 non-specific DNA binding site [nucleotide binding]; other site
340322000482 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
340322000483 sequence-specific DNA binding site [nucleotide binding]; other site
340322000484 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
340322000485 catalytic tetrad [active]
340322000486 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
340322000487 active site
340322000488 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340322000489 ATPases associated with a variety of cellular activities; Region: AAA; smart00382
340322000490 Walker A motif; other site
340322000491 ATP binding site [chemical binding]; other site
340322000492 Walker B motif; other site
340322000493 arginine finger; other site
340322000494 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737
340322000495 DDE domain; Region: DDE_Tnp_IS240; pfam13610
340322000496 Integrase core domain; Region: rve; pfam00665
340322000497 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
340322000498 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
340322000499 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
340322000500 NAD(P) binding site [chemical binding]; other site
340322000501 catalytic residues [active]
340322000502 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
340322000503 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
340322000504 active site
340322000505 catalytic tetrad [active]
340322000506 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
340322000507 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
340322000508 amidohydrolase; Region: amidohydrolases; TIGR01891
340322000509 metal binding site [ion binding]; metal-binding site
340322000510 Predicted membrane protein [Function unknown]; Region: COG2149
340322000511 Domain of unknown function (DUF202); Region: DUF202; pfam02656
340322000512 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340322000513 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
340322000514 non-specific DNA binding site [nucleotide binding]; other site
340322000515 salt bridge; other site
340322000516 sequence-specific DNA binding site [nucleotide binding]; other site
340322000517 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
340322000518 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
340322000519 DeoR C terminal sensor domain; Region: DeoRC; pfam00455
340322000520 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
340322000521 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
340322000522 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
340322000523 active site
340322000524 motif I; other site
340322000525 motif II; other site
340322000526 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
340322000527 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
340322000528 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
340322000529 catalytic core [active]
340322000530 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
340322000531 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
340322000532 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
340322000533 polyol permease family; Region: 2A0118; TIGR00897
340322000534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322000535 putative substrate translocation pore; other site
340322000536 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
340322000537 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
340322000538 DeoR C terminal sensor domain; Region: DeoRC; pfam00455
340322000539 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
340322000540 D-xylulose kinase; Region: XylB; TIGR01312
340322000541 nucleotide binding site [chemical binding]; other site
340322000542 Pantoate-beta-alanine ligase; Region: PanC; cd00560
340322000543 pantoate--beta-alanine ligase; Region: panC; TIGR00018
340322000544 active site
340322000545 ATP-binding site [chemical binding]; other site
340322000546 pantoate-binding site; other site
340322000547 HXXH motif; other site
340322000548 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
340322000549 oligomerization interface [polypeptide binding]; other site
340322000550 active site
340322000551 metal binding site [ion binding]; metal-binding site
340322000552 Fic family protein [Function unknown]; Region: COG3177
340322000553 Fic/DOC family; Region: Fic; pfam02661
340322000554 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
340322000555 active site
340322000556 DNA binding site [nucleotide binding]
340322000557 hypothetical protein; Provisional; Region: PRK07758
340322000558 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
340322000559 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
340322000560 substrate binding pocket [chemical binding]; other site
340322000561 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
340322000562 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
340322000563 motif II; other site
340322000564 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
340322000565 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
340322000566 trimer interface [polypeptide binding]; other site
340322000567 putative metal binding site [ion binding]; other site
340322000568 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
340322000569 putative DNA binding site [nucleotide binding]; other site
340322000570 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
340322000571 enterobactin exporter EntS; Provisional; Region: PRK10489
340322000572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322000573 putative substrate translocation pore; other site
340322000574 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
340322000575 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
340322000576 DXD motif; other site
340322000577 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
340322000578 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
340322000579 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
340322000580 Ankyrin repeats (many copies); Region: Ank_5; pfam13857
340322000581 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
340322000582 DeoR C terminal sensor domain; Region: DeoRC; pfam00455
340322000583 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
340322000584 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
340322000585 active site
340322000586 intersubunit interface [polypeptide binding]; other site
340322000587 catalytic residue [active]
340322000588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322000589 D-galactonate transporter; Region: 2A0114; TIGR00893
340322000590 putative substrate translocation pore; other site
340322000591 AAA domain; Region: AAA_33; pfam13671
340322000592 AAA domain; Region: AAA_17; pfam13207
340322000593 Sulfite exporter TauE/SafE; Region: TauE; pfam01925
340322000594 Predicted permeases [General function prediction only]; Region: RarD; COG2962
340322000595 Predicted membrane protein [Function unknown]; Region: COG2860
340322000596 UPF0126 domain; Region: UPF0126; pfam03458
340322000597 UPF0126 domain; Region: UPF0126; pfam03458
340322000598 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187
340322000599 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
340322000600 tetramerization interface [polypeptide binding]; other site
340322000601 active site
340322000602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805
340322000603 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
340322000604 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
340322000605 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
340322000606 hypothetical protein; Provisional; Region: PRK10621
340322000607 Sulfite exporter TauE/SafE; Region: TauE; pfam01925
340322000608 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
340322000609 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
340322000610 putative Mg++ binding site [ion binding]; other site
340322000611 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
340322000612 nucleotide binding region [chemical binding]; other site
340322000613 ATP-binding site [chemical binding]; other site
340322000614 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
340322000615 maltose O-acetyltransferase; Provisional; Region: PRK10092
340322000616 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
340322000617 active site
340322000618 substrate binding site [chemical binding]; other site
340322000619 trimer interface [polypeptide binding]; other site
340322000620 CoA binding site [chemical binding]; other site
340322000621 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
340322000622 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
340322000623 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
340322000624 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
340322000625 RNA binding surface [nucleotide binding]; other site
340322000626 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
340322000627 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
340322000628 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
340322000629 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
340322000630 DNA binding site [nucleotide binding]
340322000631 active site
340322000632 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
340322000633 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
340322000634 homotrimer interaction site [polypeptide binding]; other site
340322000635 putative active site [active]
340322000636 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
340322000637 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
340322000638 active site
340322000639 Zn binding site [ion binding]; other site
340322000640 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
340322000641 Transcriptional regulators [Transcription]; Region: PhnF; COG2188
340322000642 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
340322000643 DNA-binding site [nucleotide binding]; DNA binding site
340322000644 UTRA domain; Region: UTRA; pfam07702
340322000645 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
340322000646 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
340322000647 substrate binding site [chemical binding]; other site
340322000648 ATP binding site [chemical binding]; other site
340322000649 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
340322000650 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
340322000651 tetrameric interface [polypeptide binding]; other site
340322000652 NAD binding site [chemical binding]; other site
340322000653 catalytic residues [active]
340322000654 KduI/IolB family; Region: KduI; cl01508
340322000655 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
340322000656 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
340322000657 PYR/PP interface [polypeptide binding]; other site
340322000658 dimer interface [polypeptide binding]; other site
340322000659 TPP binding site [chemical binding]; other site
340322000660 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
340322000661 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
340322000662 TPP-binding site; other site
340322000663 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
340322000664 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
340322000665 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
340322000666 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
340322000667 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
340322000668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322000669 Major Facilitator Superfamily; Region: MFS_1; pfam07690
340322000670 putative substrate translocation pore; other site
340322000671 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
340322000672 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
340322000673 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
340322000674 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
340322000675 Transcriptional regulators [Transcription]; Region: PurR; COG1609
340322000676 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
340322000677 DNA binding site [nucleotide binding]
340322000678 domain linker motif; other site
340322000679 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
340322000680 dimerization interface [polypeptide binding]; other site
340322000681 ligand binding site [chemical binding]; other site
340322000682 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
340322000683 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
340322000684 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
340322000685 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
340322000686 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
340322000687 DNA-binding site [nucleotide binding]; DNA binding site
340322000688 RNA-binding motif; other site
340322000689 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
340322000690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322000691 dimer interface [polypeptide binding]; other site
340322000692 conserved gate region; other site
340322000693 putative PBP binding loops; other site
340322000694 ABC-ATPase subunit interface; other site
340322000695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322000696 dimer interface [polypeptide binding]; other site
340322000697 conserved gate region; other site
340322000698 putative PBP binding loops; other site
340322000699 ABC-ATPase subunit interface; other site
340322000700 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
340322000701 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
340322000702 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322000703 Walker A/P-loop; other site
340322000704 ATP binding site [chemical binding]; other site
340322000705 Q-loop/lid; other site
340322000706 ABC transporter signature motif; other site
340322000707 Walker B; other site
340322000708 D-loop; other site
340322000709 H-loop/switch region; other site
340322000710 TOBE domain; Region: TOBE_2; pfam08402
340322000711 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
340322000712 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
340322000713 motif II; other site
340322000714 Transcriptional regulators [Transcription]; Region: PurR; COG1609
340322000715 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
340322000716 DNA binding site [nucleotide binding]
340322000717 domain linker motif; other site
340322000718 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
340322000719 dimerization interface [polypeptide binding]; other site
340322000720 ligand binding site [chemical binding]; other site
340322000721 Predicted O-methyltransferase [General function prediction only]; Region: COG4122
340322000722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340322000723 S-adenosylmethionine binding site [chemical binding]; other site
340322000724 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
340322000725 Acetyltransferases [General function prediction only]; Region: RimI; COG0456
340322000726 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
340322000727 Coenzyme A binding pocket [chemical binding]; other site
340322000728 Transcriptional regulators [Transcription]; Region: PurR; COG1609
340322000729 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
340322000730 DNA binding site [nucleotide binding]
340322000731 domain linker motif; other site
340322000732 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
340322000733 dimerization interface [polypeptide binding]; other site
340322000734 ligand binding site [chemical binding]; other site
340322000735 Sugar (and other) transporter; Region: Sugar_tr; pfam00083
340322000736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322000737 putative substrate translocation pore; other site
340322000738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322000739 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
340322000740 PAS domain; Region: PAS_9; pfam13426
340322000741 putative active site [active]
340322000742 heme pocket [chemical binding]; other site
340322000743 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
340322000744 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
340322000745 active site
340322000746 dimer interface [polypeptide binding]; other site
340322000747 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
340322000748 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
340322000749 active site
340322000750 FMN binding site [chemical binding]; other site
340322000751 substrate binding site [chemical binding]; other site
340322000752 3Fe-4S cluster binding site [ion binding]; other site
340322000753 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
340322000754 domain interface; other site
340322000755 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
340322000756 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
340322000757 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
340322000758 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
340322000759 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
340322000760 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249
340322000761 short chain dehydrogenase; Provisional; Region: PRK07904
340322000762 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
340322000763 NAD(P) binding site [chemical binding]; other site
340322000764 active site
340322000765 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
340322000766 FAD binding domain; Region: FAD_binding_4; pfam01565
340322000767 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
340322000768 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
340322000769 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
340322000770 Predicted membrane protein [Function unknown]; Region: COG2246
340322000771 GtrA-like protein; Region: GtrA; pfam04138
340322000772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
340322000773 MOSC domain; Region: MOSC; pfam03473
340322000774 Predicted glycosyltransferases [General function prediction only]; Region: COG1216
340322000775 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
340322000776 active site
340322000777 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
340322000778 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
340322000779 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
340322000780 Walker A/P-loop; other site
340322000781 ATP binding site [chemical binding]; other site
340322000782 Q-loop/lid; other site
340322000783 ABC transporter signature motif; other site
340322000784 Walker B; other site
340322000785 D-loop; other site
340322000786 H-loop/switch region; other site
340322000787 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
340322000788 ABC-2 type transporter; Region: ABC2_membrane; pfam01061
340322000789 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
340322000790 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
340322000791 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
340322000792 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
340322000793 NAD(P) binding site [chemical binding]; other site
340322000794 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
340322000795 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
340322000796 hypothetical protein; Provisional; Region: PRK11568
340322000797 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597
340322000798 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
340322000799 ATP binding site [chemical binding]; other site
340322000800 substrate interface [chemical binding]; other site
340322000801 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
340322000802 active site residue [active]
340322000803 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
340322000804 MoaE homodimer interface [polypeptide binding]; other site
340322000805 MoaD interaction [polypeptide binding]; other site
340322000806 active site residues [active]
340322000807 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
340322000808 MPT binding site; other site
340322000809 trimer interface [polypeptide binding]; other site
340322000810 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
340322000811 trimer interface [polypeptide binding]; other site
340322000812 dimer interface [polypeptide binding]; other site
340322000813 putative active site [active]
340322000814 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
340322000815 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
340322000816 dimer interface [polypeptide binding]; other site
340322000817 putative functional site; other site
340322000818 putative MPT binding site; other site
340322000819 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
340322000820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322000821 dimer interface [polypeptide binding]; other site
340322000822 conserved gate region; other site
340322000823 putative PBP binding loops; other site
340322000824 ABC-ATPase subunit interface; other site
340322000825 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
340322000826 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
340322000827 Ubiquitin-like proteins; Region: UBQ; cl00155
340322000828 charged pocket; other site
340322000829 hydrophobic patch; other site
340322000830 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
340322000831 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
340322000832 Walker A/P-loop; other site
340322000833 ATP binding site [chemical binding]; other site
340322000834 Q-loop/lid; other site
340322000835 ABC transporter signature motif; other site
340322000836 Walker B; other site
340322000837 D-loop; other site
340322000838 H-loop/switch region; other site
340322000839 Predicted membrane protein [Function unknown]; Region: COG1950
340322000840 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
340322000841 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
340322000842 pyridoxal 5'-phosphate binding site [chemical binding]; other site
340322000843 homodimer interface [polypeptide binding]; other site
340322000844 catalytic residue [active]
340322000845 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
340322000846 MgtE intracellular N domain; Region: MgtE_N; pfam03448
340322000847 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
340322000848 Divalent cation transporter; Region: MgtE; cl00786
340322000849 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
340322000850 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
340322000851 transmembrane helices; other site
340322000852 prephenate dehydrogenase; Validated; Region: PRK06545
340322000853 prephenate dehydrogenase; Validated; Region: PRK08507
340322000854 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
340322000855 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
340322000856 nucleoside/Zn binding site; other site
340322000857 dimer interface [polypeptide binding]; other site
340322000858 catalytic motif [active]
340322000859 CsbD-like; Region: CsbD; cl17424
340322000860 MMPL family; Region: MMPL; pfam03176
340322000861 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
340322000862 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
340322000863 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
340322000864 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
340322000865 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
340322000866 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322000867 Q-loop/lid; other site
340322000868 ABC transporter signature motif; other site
340322000869 Walker B; other site
340322000870 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
340322000871 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
340322000872 active site
340322000873 HIGH motif; other site
340322000874 nucleotide binding site [chemical binding]; other site
340322000875 active site
340322000876 KMSKS motif; other site
340322000877 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
340322000878 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457
340322000879 putative active site [active]
340322000880 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
340322000881 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
340322000882 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
340322000883 catalytic residue [active]
340322000884 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
340322000885 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
340322000886 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340322000887 Walker A motif; other site
340322000888 ATP binding site [chemical binding]; other site
340322000889 Walker B motif; other site
340322000890 arginine finger; other site
340322000891 hypothetical protein; Validated; Region: PRK00153
340322000892 recombination protein RecR; Reviewed; Region: recR; PRK00076
340322000893 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278
340322000894 RecR protein; Region: RecR; pfam02132
340322000895 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
340322000896 putative active site [active]
340322000897 putative metal-binding site [ion binding]; other site
340322000898 tetramer interface [polypeptide binding]; other site
340322000899 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
340322000900 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
340322000901 acyl-activating enzyme (AAE) consensus motif; other site
340322000902 AMP binding site [chemical binding]; other site
340322000903 active site
340322000904 CoA binding site [chemical binding]; other site
340322000905 Phosphopantetheine attachment site; Region: PP-binding; pfam00550
340322000906 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
340322000907 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
340322000908 putative trimer interface [polypeptide binding]; other site
340322000909 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
340322000910 putative CoA binding site [chemical binding]; other site
340322000911 putative CoA binding site [chemical binding]; other site
340322000912 putative trimer interface [polypeptide binding]; other site
340322000913 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
340322000914 putative trimer interface [polypeptide binding]; other site
340322000915 putative CoA binding site [chemical binding]; other site
340322000916 Predicted membrane protein [Function unknown]; Region: COG2311
340322000917 Protein of unknown function (DUF418); Region: DUF418; pfam04235
340322000918 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
340322000919 catalytic triad [active]
340322000920 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
340322000921 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
340322000922 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
340322000923 DNA polymerase III subunit epsilon; Validated; Region: PRK05601
340322000924 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
340322000925 active site
340322000926 substrate binding site [chemical binding]; other site
340322000927 2-isopropylmalate synthase; Validated; Region: PRK03739
340322000928 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
340322000929 active site
340322000930 catalytic residues [active]
340322000931 metal binding site [ion binding]; metal-binding site
340322000932 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
340322000933 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
340322000934 aspartate kinase; Reviewed; Region: PRK06635
340322000935 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
340322000936 putative nucleotide binding site [chemical binding]; other site
340322000937 putative catalytic residues [active]
340322000938 putative Mg ion binding site [ion binding]; other site
340322000939 putative aspartate binding site [chemical binding]; other site
340322000940 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
340322000941 putative allosteric regulatory site; other site
340322000942 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
340322000943 putative allosteric regulatory residue; other site
340322000944 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
340322000945 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
340322000946 RNA polymerase sigma factor; Provisional; Region: PRK12535
340322000947 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
340322000948 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
340322000949 DNA binding residues [nucleotide binding]
340322000950 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
340322000951 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
340322000952 heme binding pocket [chemical binding]; other site
340322000953 Transcriptional regulators [Transcription]; Region: Lrp; COG1522
340322000954 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
340322000955 AsnC family; Region: AsnC_trans_reg; pfam01037
340322000956 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
340322000957 Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687
340322000958 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
340322000959 dimerization interface [polypeptide binding]; other site
340322000960 putative DNA binding site [nucleotide binding]; other site
340322000961 putative Zn2+ binding site [ion binding]; other site
340322000962 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
340322000963 arsenical-resistance protein; Region: acr3; TIGR00832
340322000964 Low molecular weight phosphatase family; Region: LMWPc; cl00105
340322000965 active site
340322000966 Low molecular weight phosphatase family; Region: LMWPc; cl00105
340322000967 Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320
340322000968 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612
340322000969 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654
340322000970 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
340322000971 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
340322000972 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
340322000973 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650
340322000974 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
340322000975 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
340322000976 Domain of unknown function (DUF4040); Region: DUF4040; cl00676
340322000977 Predicted membrane protein [Function unknown]; Region: COG1511
340322000978 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274
340322000979 Malonate transporter MadL subunit; Region: MadL; cl04273
340322000980 Transcriptional regulator [Transcription]; Region: LysR; COG0583
340322000981 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
340322000982 dimerization interface [polypeptide binding]; other site
340322000983 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
340322000984 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
340322000985 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
340322000986 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293; cl07913
340322000987 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134
340322000988 malonate decarboxylase acyl carrier protein; Region: malonate_delta; TIGR03130
340322000989 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
340322000990 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874
340322000991 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
340322000992 Coenzyme A transferase; Region: CoA_trans; cl17247
340322000993 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
340322000994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
340322000995 active site
340322000996 phosphorylation site [posttranslational modification]
340322000997 intermolecular recognition site; other site
340322000998 dimerization interface [polypeptide binding]; other site
340322000999 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
340322001000 DNA binding site [nucleotide binding]
340322001001 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
340322001002 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
340322001003 dimerization interface [polypeptide binding]; other site
340322001004 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
340322001005 dimer interface [polypeptide binding]; other site
340322001006 phosphorylation site [posttranslational modification]
340322001007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
340322001008 ATP binding site [chemical binding]; other site
340322001009 Mg2+ binding site [ion binding]; other site
340322001010 G-X-G motif; other site
340322001011 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
340322001012 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
340322001013 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
340322001014 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
340322001015 putative active site [active]
340322001016 putative metal binding site [ion binding]; other site
340322001017 Yqey-like protein; Region: YqeY; pfam09424
340322001018 Transglycosylase; Region: Transgly; pfam00912
340322001019 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
340322001020 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
340322001021 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
340322001022 Transcription factor WhiB; Region: Whib; pfam02467
340322001023 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
340322001024 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
340322001025 homotrimer interaction site [polypeptide binding]; other site
340322001026 putative active site [active]
340322001027 metabolite-proton symporter; Region: 2A0106; TIGR00883
340322001028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322001029 putative substrate translocation pore; other site
340322001030 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
340322001031 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
340322001032 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
340322001033 acyl-activating enzyme (AAE) consensus motif; other site
340322001034 acyl-activating enzyme (AAE) consensus motif; other site
340322001035 putative AMP binding site [chemical binding]; other site
340322001036 putative active site [active]
340322001037 putative CoA binding site [chemical binding]; other site
340322001038 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
340322001039 Winged helix DNA-binding domain; Region: HTH_27; pfam13463
340322001040 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
340322001041 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
340322001042 NAD(P) binding site [chemical binding]; other site
340322001043 active site
340322001044 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
340322001045 active site
340322001046 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
340322001047 acyl-coenzyme A oxidase; Region: PLN02526
340322001048 active site
340322001049 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
340322001050 putative active site [active]
340322001051 putative catalytic site [active]
340322001052 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
340322001053 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
340322001054 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
340322001055 ligand binding site [chemical binding]; other site
340322001056 flexible hinge region; other site
340322001057 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
340322001058 putative switch regulator; other site
340322001059 non-specific DNA interactions [nucleotide binding]; other site
340322001060 DNA binding site [nucleotide binding]
340322001061 sequence specific DNA binding site [nucleotide binding]; other site
340322001062 putative cAMP binding site [chemical binding]; other site
340322001063 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
340322001064 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
340322001065 minor groove reading motif; other site
340322001066 helix-hairpin-helix signature motif; other site
340322001067 substrate binding pocket [chemical binding]; other site
340322001068 active site
340322001069 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
340322001070 Thioredoxin-like; Region: Thioredoxin_8; pfam13905
340322001071 catalytic residues [active]
340322001072 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
340322001073 putative active site [active]
340322001074 putative CoA binding site [chemical binding]; other site
340322001075 nudix motif; other site
340322001076 metal binding site [ion binding]; metal-binding site
340322001077 Colicin V production protein; Region: Colicin_V; pfam02674
340322001078 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
340322001079 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
340322001080 active site
340322001081 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
340322001082 Putative lysophospholipase; Region: Hydrolase_4; pfam12146
340322001083 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
340322001084 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
340322001085 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
340322001086 motif II; other site
340322001087 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
340322001088 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
340322001089 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
340322001090 ATP binding site [chemical binding]; other site
340322001091 Walker A motif; other site
340322001092 hexamer interface [polypeptide binding]; other site
340322001093 Walker B motif; other site
340322001094 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
340322001095 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
340322001096 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
340322001097 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
340322001098 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
340322001099 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
340322001100 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
340322001101 ATP binding site [chemical binding]; other site
340322001102 putative Mg++ binding site [ion binding]; other site
340322001103 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
340322001104 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
340322001105 DNA-binding site [nucleotide binding]; DNA binding site
340322001106 RNA-binding motif; other site
340322001107 DNA topoisomerase I subunit omega; Validated; Region: PRK07561
340322001108 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
340322001109 active site
340322001110 interdomain interaction site; other site
340322001111 putative metal-binding site [ion binding]; other site
340322001112 nucleotide binding site [chemical binding]; other site
340322001113 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
340322001114 domain I; other site
340322001115 DNA binding groove [nucleotide binding]
340322001116 phosphate binding site [ion binding]; other site
340322001117 domain II; other site
340322001118 domain III; other site
340322001119 nucleotide binding site [chemical binding]; other site
340322001120 catalytic site [active]
340322001121 domain IV; other site
340322001122 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
340322001123 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
340322001124 YhhN-like protein; Region: YhhN; pfam07947
340322001125 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
340322001126 dimerization interface [polypeptide binding]; other site
340322001127 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
340322001128 cyclase homology domain; Region: CHD; cd07302
340322001129 nucleotidyl binding site; other site
340322001130 metal binding site [ion binding]; metal-binding site
340322001131 dimer interface [polypeptide binding]; other site
340322001132 DNA polymerase III subunit delta'; Validated; Region: PRK07940
340322001133 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
340322001134 Walker A motif; other site
340322001135 ATP binding site [chemical binding]; other site
340322001136 Walker B motif; other site
340322001137 arginine finger; other site
340322001138 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
340322001139 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
340322001140 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019
340322001141 active site
340322001142 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
340322001143 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
340322001144 RNA binding surface [nucleotide binding]; other site
340322001145 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
340322001146 active site
340322001147 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
340322001148 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
340322001149 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
340322001150 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
340322001151 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
340322001152 NAD binding site [chemical binding]; other site
340322001153 catalytic Zn binding site [ion binding]; other site
340322001154 substrate binding site [chemical binding]; other site
340322001155 structural Zn binding site [ion binding]; other site
340322001156 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
340322001157 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
340322001158 classical (c) SDRs; Region: SDR_c; cd05233
340322001159 NAD(P) binding site [chemical binding]; other site
340322001160 active site
340322001161 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
340322001162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
340322001163 NAD(P) binding site [chemical binding]; other site
340322001164 active site
340322001165 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
340322001166 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
340322001167 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
340322001168 Ligand binding site; other site
340322001169 Putative Catalytic site; other site
340322001170 DXD motif; other site
340322001171 Ribonuclease HI [DNA replication, recombination, and repair]; Region: RnhA; COG0328
340322001172 RNA/DNA hybrid binding site [nucleotide binding]; other site
340322001173 active site
340322001174 Predicted glycosyltransferases [General function prediction only]; Region: COG1216
340322001175 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
340322001176 Probable Catalytic site; other site
340322001177 metal-binding site
340322001178 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
340322001179 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
340322001180 putative active site [active]
340322001181 putative metal binding site [ion binding]; other site
340322001182 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
340322001183 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
340322001184 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
340322001185 putative NAD(P) binding site [chemical binding]; other site
340322001186 putative substrate binding site [chemical binding]; other site
340322001187 catalytic Zn binding site [ion binding]; other site
340322001188 structural Zn binding site [ion binding]; other site
340322001189 dimer interface [polypeptide binding]; other site
340322001190 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
340322001191 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
340322001192 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
340322001193 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
340322001194 substrate binding site; other site
340322001195 tetramer interface; other site
340322001196 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
340322001197 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
340322001198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
340322001199 NAD(P) binding site [chemical binding]; other site
340322001200 active site
340322001201 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
340322001202 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
340322001203 NAD binding site [chemical binding]; other site
340322001204 substrate binding site [chemical binding]; other site
340322001205 homodimer interface [polypeptide binding]; other site
340322001206 active site
340322001207 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370
340322001208 dimer interface [polypeptide binding]; other site
340322001209 FMN binding site [chemical binding]; other site
340322001210 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
340322001211 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
340322001212 siderophore binding site; other site
340322001213 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
340322001214 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
340322001215 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
340322001216 Zn binding site [ion binding]; other site
340322001217 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
340322001218 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
340322001219 Excalibur calcium-binding domain; Region: Excalibur; smart00894
340322001220 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
340322001221 Putative esterase; Region: Esterase; pfam00756
340322001222 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
340322001223 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
340322001224 active site
340322001225 homodimer interface [polypeptide binding]; other site
340322001226 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
340322001227 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063
340322001228 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
340322001229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
340322001230 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
340322001231 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
340322001232 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
340322001233 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
340322001234 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
340322001235 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
340322001236 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
340322001237 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
340322001238 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
340322001239 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
340322001240 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
340322001241 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
340322001242 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
340322001243 active site
340322001244 tetramer interface; other site
340322001245 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
340322001246 putative deacylase active site [active]
340322001247 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
340322001248 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340322001249 non-specific DNA binding site [nucleotide binding]; other site
340322001250 salt bridge; other site
340322001251 sequence-specific DNA binding site [nucleotide binding]; other site
340322001252 Predicted transcriptional regulator [General function prediction only]; Region: COG3800
340322001253 Domain of unknown function (DUF955); Region: DUF955; pfam06114
340322001254 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
340322001255 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
340322001256 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
340322001257 putative Iron-sulfur protein interface [polypeptide binding]; other site
340322001258 proximal heme binding site [chemical binding]; other site
340322001259 distal heme binding site [chemical binding]; other site
340322001260 putative dimer interface [polypeptide binding]; other site
340322001261 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
340322001262 L-aspartate oxidase; Provisional; Region: PRK06175
340322001263 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
340322001264 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
340322001265 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
340322001266 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
340322001267 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
340322001268 intersubunit interface [polypeptide binding]; other site
340322001269 Uncharacterized conserved protein [Function unknown]; Region: COG4127
340322001270 Restriction endonuclease; Region: Mrr_cat; pfam04471
340322001271 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
340322001272 Predicted membrane protein [Function unknown]; Region: COG2733
340322001273 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
340322001274 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
340322001275 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
340322001276 Major Facilitator Superfamily; Region: MFS_1; pfam07690
340322001277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322001278 putative substrate translocation pore; other site
340322001279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322001280 putative substrate translocation pore; other site
340322001281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322001282 Major Facilitator Superfamily; Region: MFS_1; pfam07690
340322001283 putative substrate translocation pore; other site
340322001284 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
340322001285 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
340322001286 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
340322001287 putative active site [active]
340322001288 putative substrate binding site [chemical binding]; other site
340322001289 putative cosubstrate binding site; other site
340322001290 catalytic site [active]
340322001291 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
340322001292 intersubunit interface [polypeptide binding]; other site
340322001293 active site
340322001294 catalytic residue [active]
340322001295 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
340322001296 putative homodimer interface [polypeptide binding]; other site
340322001297 putative homotetramer interface [polypeptide binding]; other site
340322001298 putative allosteric switch controlling residues; other site
340322001299 putative metal binding site [ion binding]; other site
340322001300 putative homodimer-homodimer interface [polypeptide binding]; other site
340322001301 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
340322001302 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
340322001303 metal-binding site [ion binding]
340322001304 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
340322001305 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
340322001306 ATP-dependent protease Lon; Provisional; Region: PRK13765
340322001307 Htaa; Region: HtaA; pfam04213
340322001308 Htaa; Region: HtaA; pfam04213
340322001309 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
340322001310 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
340322001311 intersubunit interface [polypeptide binding]; other site
340322001312 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
340322001313 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
340322001314 dimer interface [polypeptide binding]; other site
340322001315 putative PBP binding regions; other site
340322001316 ABC-ATPase subunit interface; other site
340322001317 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559
340322001318 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
340322001319 Walker A/P-loop; other site
340322001320 ATP binding site [chemical binding]; other site
340322001321 Q-loop/lid; other site
340322001322 ABC transporter signature motif; other site
340322001323 Walker B; other site
340322001324 D-loop; other site
340322001325 H-loop/switch region; other site
340322001326 Htaa; Region: HtaA; pfam04213
340322001327 Htaa; Region: HtaA; pfam04213
340322001328 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
340322001329 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
340322001330 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
340322001331 FAD binding domain; Region: FAD_binding_4; pfam01565
340322001332 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
340322001333 hypothetical protein; Provisional; Region: PRK07758
340322001334 Domain of unknown function (DU1801); Region: DUF1801; pfam08818
340322001335 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605
340322001336 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
340322001337 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
340322001338 acyl-activating enzyme (AAE) consensus motif; other site
340322001339 AMP binding site [chemical binding]; other site
340322001340 active site
340322001341 CoA binding site [chemical binding]; other site
340322001342 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
340322001343 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
340322001344 putative ADP-binding pocket [chemical binding]; other site
340322001345 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
340322001346 catalytic core [active]
340322001347 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
340322001348 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
340322001349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
340322001350 dimer interface [polypeptide binding]; other site
340322001351 phosphorylation site [posttranslational modification]
340322001352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
340322001353 ATP binding site [chemical binding]; other site
340322001354 Mg2+ binding site [ion binding]; other site
340322001355 G-X-G motif; other site
340322001356 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
340322001357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
340322001358 active site
340322001359 phosphorylation site [posttranslational modification]
340322001360 intermolecular recognition site; other site
340322001361 dimerization interface [polypeptide binding]; other site
340322001362 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
340322001363 DNA binding site [nucleotide binding]
340322001364 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
340322001365 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
340322001366 FtsX-like permease family; Region: FtsX; pfam02687
340322001367 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
340322001368 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
340322001369 FtsX-like permease family; Region: FtsX; pfam02687
340322001370 exopolyphosphatase; Region: exo_poly_only; TIGR03706
340322001371 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
340322001372 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
340322001373 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
340322001374 DNA binding domain, excisionase family; Region: excise; TIGR01764
340322001375 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
340322001376 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1
340322001377 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
340322001378 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
340322001379 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
340322001380 tRNA; other site
340322001381 putative tRNA binding site [nucleotide binding]; other site
340322001382 putative NADP binding site [chemical binding]; other site
340322001383 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
340322001384 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
340322001385 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
340322001386 domain interfaces; other site
340322001387 active site
340322001388 Transcriptional regulator [Transcription]; Region: LysR; COG0583
340322001389 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
340322001390 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
340322001391 dimerization interface [polypeptide binding]; other site
340322001392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322001393 metabolite-proton symporter; Region: 2A0106; TIGR00883
340322001394 putative substrate translocation pore; other site
340322001395 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
340322001396 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
340322001397 AP (apurinic/apyrimidinic) site pocket; other site
340322001398 DNA interaction; other site
340322001399 Metal-binding active site; metal-binding site
340322001400 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
340322001401 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
340322001402 active site
340322001403 metal binding site [ion binding]; metal-binding site
340322001404 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
340322001405 active site
340322001406 Fe binding site [ion binding]; other site
340322001407 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
340322001408 Dehydroquinase class II; Region: DHquinase_II; pfam01220
340322001409 active site
340322001410 trimer interface [polypeptide binding]; other site
340322001411 dimer interface [polypeptide binding]; other site
340322001412 quinate/shikimate dehydrogenase; Provisional; Region: PRK14027
340322001413 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
340322001414 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
340322001415 shikimate binding site; other site
340322001416 NAD(P) binding site [chemical binding]; other site
340322001417 Ribosomal protein L7/L12 [Translation, ribosomal structure and biogenesis]; Region: RplL; COG0222
340322001418 L11 interface [polypeptide binding]; other site
340322001419 putative EF-Tu interaction site [polypeptide binding]; other site
340322001420 putative EF-G interaction site [polypeptide binding]; other site
340322001421 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
340322001422 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
340322001423 Walker A/P-loop; other site
340322001424 ATP binding site [chemical binding]; other site
340322001425 Q-loop/lid; other site
340322001426 ABC transporter signature motif; other site
340322001427 Walker B; other site
340322001428 D-loop; other site
340322001429 H-loop/switch region; other site
340322001430 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
340322001431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322001432 dimer interface [polypeptide binding]; other site
340322001433 conserved gate region; other site
340322001434 putative PBP binding loops; other site
340322001435 ABC-ATPase subunit interface; other site
340322001436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
340322001437 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
340322001438 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
340322001439 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
340322001440 active site
340322001441 homodimer interface [polypeptide binding]; other site
340322001442 SAM binding site [chemical binding]; other site
340322001443 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
340322001444 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
340322001445 active site
340322001446 Domain of unknown function (DUF3806); Region: DUF3806; pfam12713
340322001447 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
340322001448 dimer interface [polypeptide binding]; other site
340322001449 active site
340322001450 Schiff base residues; other site
340322001451 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
340322001452 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
340322001453 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
340322001454 substrate binding site [chemical binding]; other site
340322001455 active site
340322001456 protoporphyrinogen oxidase; Reviewed; Region: PRK11883
340322001457 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
340322001458 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
340322001459 inhibitor-cofactor binding pocket; inhibition site
340322001460 pyridoxal 5'-phosphate binding site [chemical binding]; other site
340322001461 catalytic residue [active]
340322001462 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
340322001463 catalytic core [active]
340322001464 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
340322001465 Thioredoxin-like; Region: Thioredoxin_8; pfam13905
340322001466 catalytic residues [active]
340322001467 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
340322001468 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
340322001469 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
340322001470 ResB-like family; Region: ResB; pfam05140
340322001471 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
340322001472 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
340322001473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322001474 dimer interface [polypeptide binding]; other site
340322001475 conserved gate region; other site
340322001476 putative PBP binding loops; other site
340322001477 ABC-ATPase subunit interface; other site
340322001478 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
340322001479 NMT1/THI5 like; Region: NMT1; pfam09084
340322001480 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005
340322001481 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
340322001482 Walker A/P-loop; other site
340322001483 ATP binding site [chemical binding]; other site
340322001484 Q-loop/lid; other site
340322001485 ABC transporter signature motif; other site
340322001486 Walker B; other site
340322001487 D-loop; other site
340322001488 H-loop/switch region; other site
340322001489 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
340322001490 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
340322001491 active site
340322001492 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
340322001493 homotrimer interaction site [polypeptide binding]; other site
340322001494 putative active site [active]
340322001495 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
340322001496 putative DNA binding site [nucleotide binding]; other site
340322001497 dimerization interface [polypeptide binding]; other site
340322001498 putative Zn2+ binding site [ion binding]; other site
340322001499 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012
340322001500 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
340322001501 UbiA prenyltransferase family; Region: UbiA; pfam01040
340322001502 acetolactate synthase catalytic subunit; Validated; Region: PRK08327
340322001503 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
340322001504 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
340322001505 acyl-activating enzyme (AAE) consensus motif; other site
340322001506 AMP binding site [chemical binding]; other site
340322001507 active site
340322001508 CoA binding site [chemical binding]; other site
340322001509 Predicted membrane protein [Function unknown]; Region: COG2259
340322001510 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
340322001511 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
340322001512 dimer interface [polypeptide binding]; other site
340322001513 NADP binding site [chemical binding]; other site
340322001514 catalytic residues [active]
340322001515 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
340322001516 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
340322001517 putative active site [active]
340322001518 catalytic residue [active]
340322001519 Transcriptional regulator [Transcription]; Region: LysR; COG0583
340322001520 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
340322001521 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447
340322001522 putative dimerization interface [polypeptide binding]; other site
340322001523 putative substrate binding pocket [chemical binding]; other site
340322001524 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
340322001525 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
340322001526 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
340322001527 active site
340322001528 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
340322001529 active site 1 [active]
340322001530 active site 2 [active]
340322001531 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
340322001532 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
340322001533 multiple promoter invertase; Provisional; Region: mpi; PRK13413
340322001534 catalytic residues [active]
340322001535 catalytic nucleophile [active]
340322001536 Presynaptic Site I dimer interface [polypeptide binding]; other site
340322001537 Synaptic Antiparallel dimer interface [polypeptide binding]; other site
340322001538 Synaptic Flat tetramer interface [polypeptide binding]; other site
340322001539 Synaptic Site I dimer interface [polypeptide binding]; other site
340322001540 DNA binding site [nucleotide binding]
340322001541 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
340322001542 DNA-binding interface [nucleotide binding]; DNA binding site
340322001543 Uncharacterized conserved protein [Function unknown]; Region: COG1479
340322001544 Protein of unknown function DUF262; Region: DUF262; pfam03235
340322001545 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
340322001546 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
340322001547 DNA binding site [nucleotide binding]
340322001548 active site
340322001549 DDE domain; Region: DDE_Tnp_IS240; pfam13610
340322001550 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
340322001551 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
340322001552 Protein of unknown function (DUF2872); Region: DUF2872; pfam11071
340322001553 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
340322001554 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
340322001555 dimerization interface [polypeptide binding]; other site
340322001556 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
340322001557 dimer interface [polypeptide binding]; other site
340322001558 phosphorylation site [posttranslational modification]
340322001559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
340322001560 ATP binding site [chemical binding]; other site
340322001561 Mg2+ binding site [ion binding]; other site
340322001562 G-X-G motif; other site
340322001563 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
340322001564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
340322001565 active site
340322001566 phosphorylation site [posttranslational modification]
340322001567 intermolecular recognition site; other site
340322001568 dimerization interface [polypeptide binding]; other site
340322001569 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
340322001570 DNA binding site [nucleotide binding]
340322001571 Protein of unknown function (DUF1624); Region: DUF1624; cl01394
340322001572 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
340322001573 active site
340322001574 DDE domain; Region: DDE_Tnp_IS240; pfam13610
340322001575 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
340322001576 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
340322001577 DDE domain; Region: DDE_Tnp_IS240; pfam13610
340322001578 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
340322001579 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
340322001580 LGFP repeat; Region: LGFP; pfam08310
340322001581 LGFP repeat; Region: LGFP; pfam08310
340322001582 LGFP repeat; Region: LGFP; pfam08310
340322001583 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
340322001584 Integrase core domain; Region: rve; pfam00665
340322001585 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
340322001586 Integrase core domain; Region: rve; pfam00665
340322001587 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
340322001588 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
340322001589 catalytic residues [active]
340322001590 catalytic nucleophile [active]
340322001591 Presynaptic Site I dimer interface [polypeptide binding]; other site
340322001592 Synaptic Antiparallel dimer interface [polypeptide binding]; other site
340322001593 Synaptic Flat tetramer interface [polypeptide binding]; other site
340322001594 Synaptic Site I dimer interface [polypeptide binding]; other site
340322001595 DNA binding site [nucleotide binding]
340322001596 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
340322001597 DNA-binding interface [nucleotide binding]; DNA binding site
340322001598 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
340322001599 multiple promoter invertase; Provisional; Region: mpi; PRK13413
340322001600 catalytic residues [active]
340322001601 catalytic nucleophile [active]
340322001602 Presynaptic Site I dimer interface [polypeptide binding]; other site
340322001603 Synaptic Antiparallel dimer interface [polypeptide binding]; other site
340322001604 Synaptic Flat tetramer interface [polypeptide binding]; other site
340322001605 Synaptic Site I dimer interface [polypeptide binding]; other site
340322001606 DNA binding site [nucleotide binding]
340322001607 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
340322001608 DNA-binding interface [nucleotide binding]; DNA binding site
340322001609 DDE domain; Region: DDE_Tnp_IS240; pfam13610
340322001610 Integrase core domain; Region: rve; pfam00665
340322001611 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
340322001612 Predicted membrane protein [Function unknown]; Region: COG4325
340322001613 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
340322001614 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
340322001615 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
340322001616 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
340322001617 substrate binding site [chemical binding]; other site
340322001618 oxyanion hole (OAH) forming residues; other site
340322001619 trimer interface [polypeptide binding]; other site
340322001620 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
340322001621 aromatic arch; other site
340322001622 DCoH dimer interaction site [polypeptide binding]; other site
340322001623 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
340322001624 DCoH tetramer interaction site [polypeptide binding]; other site
340322001625 substrate binding site [chemical binding]; other site
340322001626 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129
340322001627 catalytic triad [active]
340322001628 active site nucleophile [active]
340322001629 O-succinylbenzoate synthase; Provisional; Region: PRK02901
340322001630 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
340322001631 active site
340322001632 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
340322001633 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
340322001634 dimer interface [polypeptide binding]; other site
340322001635 tetramer interface [polypeptide binding]; other site
340322001636 PYR/PP interface [polypeptide binding]; other site
340322001637 TPP binding site [chemical binding]; other site
340322001638 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
340322001639 TPP-binding site; other site
340322001640 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
340322001641 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
340322001642 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
340322001643 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
340322001644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340322001645 S-adenosylmethionine binding site [chemical binding]; other site
340322001646 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
340322001647 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
340322001648 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
340322001649 substrate binding pocket [chemical binding]; other site
340322001650 chain length determination region; other site
340322001651 substrate-Mg2+ binding site; other site
340322001652 catalytic residues [active]
340322001653 aspartate-rich region 1; other site
340322001654 active site lid residues [active]
340322001655 aspartate-rich region 2; other site
340322001656 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
340322001657 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
340322001658 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
340322001659 putative homodimer interface [polypeptide binding]; other site
340322001660 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
340322001661 heterodimer interface [polypeptide binding]; other site
340322001662 homodimer interface [polypeptide binding]; other site
340322001663 50S ribosomal protein L11; Validated; Region: rplK; PRK00140
340322001664 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
340322001665 23S rRNA interface [nucleotide binding]; other site
340322001666 L7/L12 interface [polypeptide binding]; other site
340322001667 putative thiostrepton binding site; other site
340322001668 L25 interface [polypeptide binding]; other site
340322001669 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
340322001670 mRNA/rRNA interface [nucleotide binding]; other site
340322001671 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
340322001672 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
340322001673 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
340322001674 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
340322001675 inhibitor-cofactor binding pocket; inhibition site
340322001676 pyridoxal 5'-phosphate binding site [chemical binding]; other site
340322001677 catalytic residue [active]
340322001678 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
340322001679 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
340322001680 tetramerization interface [polypeptide binding]; other site
340322001681 NAD(P) binding site [chemical binding]; other site
340322001682 catalytic residues [active]
340322001683 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
340322001684 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
340322001685 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
340322001686 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
340322001687 Soluble P-type ATPase [General function prediction only]; Region: COG4087
340322001688 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
340322001689 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
340322001690 Protein of unknown function (DUF541); Region: SIMPL; pfam04402
340322001691 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
340322001692 23S rRNA interface [nucleotide binding]; other site
340322001693 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
340322001694 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
340322001695 core dimer interface [polypeptide binding]; other site
340322001696 peripheral dimer interface [polypeptide binding]; other site
340322001697 L10 interface [polypeptide binding]; other site
340322001698 L11 interface [polypeptide binding]; other site
340322001699 putative EF-Tu interaction site [polypeptide binding]; other site
340322001700 putative EF-G interaction site [polypeptide binding]; other site
340322001701 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
340322001702 Tetraspanin family; Region: Tetraspannin; pfam00335
340322001703 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
340322001704 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
340322001705 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
340322001706 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
340322001707 RPB1 interaction site [polypeptide binding]; other site
340322001708 RPB10 interaction site [polypeptide binding]; other site
340322001709 RPB11 interaction site [polypeptide binding]; other site
340322001710 RPB3 interaction site [polypeptide binding]; other site
340322001711 RPB12 interaction site [polypeptide binding]; other site
340322001712 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
340322001713 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
340322001714 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
340322001715 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
340322001716 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
340322001717 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
340322001718 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
340322001719 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
340322001720 G-loop; other site
340322001721 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
340322001722 DNA binding site [nucleotide binding]
340322001723 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
340322001724 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340322001725 salt bridge; other site
340322001726 non-specific DNA binding site [nucleotide binding]; other site
340322001727 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
340322001728 sequence-specific DNA binding site [nucleotide binding]; other site
340322001729 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
340322001730 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
340322001731 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
340322001732 S17 interaction site [polypeptide binding]; other site
340322001733 S8 interaction site; other site
340322001734 16S rRNA interaction site [nucleotide binding]; other site
340322001735 streptomycin interaction site [chemical binding]; other site
340322001736 23S rRNA interaction site [nucleotide binding]; other site
340322001737 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
340322001738 30S ribosomal protein S7; Validated; Region: PRK05302
340322001739 elongation factor G; Reviewed; Region: PRK00007
340322001740 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
340322001741 G1 box; other site
340322001742 putative GEF interaction site [polypeptide binding]; other site
340322001743 GTP/Mg2+ binding site [chemical binding]; other site
340322001744 Switch I region; other site
340322001745 G2 box; other site
340322001746 G3 box; other site
340322001747 Switch II region; other site
340322001748 G4 box; other site
340322001749 G5 box; other site
340322001750 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
340322001751 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
340322001752 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
340322001753 elongation factor Tu; Reviewed; Region: PRK00049
340322001754 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
340322001755 G1 box; other site
340322001756 GEF interaction site [polypeptide binding]; other site
340322001757 GTP/Mg2+ binding site [chemical binding]; other site
340322001758 Switch I region; other site
340322001759 G2 box; other site
340322001760 G3 box; other site
340322001761 Switch II region; other site
340322001762 G4 box; other site
340322001763 G5 box; other site
340322001764 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
340322001765 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
340322001766 Antibiotic Binding Site [chemical binding]; other site
340322001767 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
340322001768 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
340322001769 Walker A/P-loop; other site
340322001770 ATP binding site [chemical binding]; other site
340322001771 Q-loop/lid; other site
340322001772 ABC transporter signature motif; other site
340322001773 Walker B; other site
340322001774 D-loop; other site
340322001775 H-loop/switch region; other site
340322001776 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
340322001777 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
340322001778 ABC-ATPase subunit interface; other site
340322001779 dimer interface [polypeptide binding]; other site
340322001780 putative PBP binding regions; other site
340322001781 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
340322001782 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
340322001783 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
340322001784 ABC-ATPase subunit interface; other site
340322001785 dimer interface [polypeptide binding]; other site
340322001786 putative PBP binding regions; other site
340322001787 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
340322001788 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
340322001789 conserved cys residue [active]
340322001790 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
340322001791 succinate CoA transferase; Region: YgfH_subfam; TIGR03458
340322001792 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
340322001793 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
340322001794 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
340322001795 50S ribosomal protein L3; Validated; Region: rplC; PRK00001
340322001796 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
340322001797 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
340322001798 50S ribosomal protein L2; Validated; Region: rplB; PRK09374
340322001799 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
340322001800 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
340322001801 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
340322001802 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
340322001803 putative translocon binding site; other site
340322001804 protein-rRNA interface [nucleotide binding]; other site
340322001805 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
340322001806 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412
340322001807 G-X-X-G motif; other site
340322001808 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
340322001809 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
340322001810 23S rRNA interface [nucleotide binding]; other site
340322001811 5S rRNA interface [nucleotide binding]; other site
340322001812 putative antibiotic binding site [chemical binding]; other site
340322001813 L25 interface [polypeptide binding]; other site
340322001814 L27 interface [polypeptide binding]; other site
340322001815 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
340322001816 putative translocon interaction site; other site
340322001817 23S rRNA interface [nucleotide binding]; other site
340322001818 signal recognition particle (SRP54) interaction site; other site
340322001819 L23 interface [polypeptide binding]; other site
340322001820 trigger factor interaction site; other site
340322001821 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
340322001822 50S ribosomal protein L14; Validated; Region: rplN; PRK05483
340322001823 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
340322001824 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
340322001825 RNA binding site [nucleotide binding]; other site
340322001826 50S ribosomal protein L5; Validated; Region: rplE; PRK00010
340322001827 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
340322001828 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
340322001829 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
340322001830 active site
340322001831 catalytic triad [active]
340322001832 oxyanion hole [active]
340322001833 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
340322001834 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
340322001835 active site
340322001836 catalytic tetrad [active]
340322001837 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
340322001838 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
340322001839 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
340322001840 putative molybdopterin cofactor binding site [chemical binding]; other site
340322001841 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
340322001842 putative molybdopterin cofactor binding site; other site
340322001843 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
340322001844 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
340322001845 Walker A/P-loop; other site
340322001846 ATP binding site [chemical binding]; other site
340322001847 Q-loop/lid; other site
340322001848 ABC transporter signature motif; other site
340322001849 Walker B; other site
340322001850 D-loop; other site
340322001851 H-loop/switch region; other site
340322001852 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
340322001853 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322001854 Walker A/P-loop; other site
340322001855 ATP binding site [chemical binding]; other site
340322001856 Q-loop/lid; other site
340322001857 ABC transporter signature motif; other site
340322001858 Walker B; other site
340322001859 D-loop; other site
340322001860 H-loop/switch region; other site
340322001861 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
340322001862 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
340322001863 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
340322001864 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
340322001865 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
340322001866 Coenzyme A binding pocket [chemical binding]; other site
340322001867 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
340322001868 50S ribosomal protein L6; Validated; Region: rplF; PRK05498
340322001869 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
340322001870 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
340322001871 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
340322001872 5S rRNA interface [nucleotide binding]; other site
340322001873 L27 interface [polypeptide binding]; other site
340322001874 23S rRNA interface [nucleotide binding]; other site
340322001875 L5 interface [polypeptide binding]; other site
340322001876 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
340322001877 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
340322001878 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
340322001879 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
340322001880 23S rRNA binding site [nucleotide binding]; other site
340322001881 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
340322001882 metabolite-proton symporter; Region: 2A0106; TIGR00883
340322001883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322001884 putative substrate translocation pore; other site
340322001885 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
340322001886 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
340322001887 acyl-activating enzyme (AAE) consensus motif; other site
340322001888 AMP binding site [chemical binding]; other site
340322001889 active site
340322001890 CoA binding site [chemical binding]; other site
340322001891 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
340322001892 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
340322001893 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
340322001894 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
340322001895 CoenzymeA binding site [chemical binding]; other site
340322001896 subunit interaction site [polypeptide binding]; other site
340322001897 PHB binding site; other site
340322001898 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
340322001899 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
340322001900 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
340322001901 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
340322001902 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
340322001903 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
340322001904 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
340322001905 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
340322001906 FAD binding pocket [chemical binding]; other site
340322001907 FAD binding motif [chemical binding]; other site
340322001908 phosphate binding motif [ion binding]; other site
340322001909 beta-alpha-beta structure motif; other site
340322001910 NAD(p) ribose binding residues [chemical binding]; other site
340322001911 NAD binding pocket [chemical binding]; other site
340322001912 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
340322001913 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
340322001914 catalytic loop [active]
340322001915 iron binding site [ion binding]; other site
340322001916 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
340322001917 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
340322001918 substrate binding site [chemical binding]; other site
340322001919 oxyanion hole (OAH) forming residues; other site
340322001920 trimer interface [polypeptide binding]; other site
340322001921 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
340322001922 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
340322001923 dimer interface [polypeptide binding]; other site
340322001924 active site
340322001925 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
340322001926 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
340322001927 substrate binding site [chemical binding]; other site
340322001928 oxyanion hole (OAH) forming residues; other site
340322001929 trimer interface [polypeptide binding]; other site
340322001930 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
340322001931 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
340322001932 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
340322001933 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
340322001934 CoenzymeA binding site [chemical binding]; other site
340322001935 subunit interaction site [polypeptide binding]; other site
340322001936 PHB binding site; other site
340322001937 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
340322001938 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
340322001939 substrate binding site [chemical binding]; other site
340322001940 dimer interface [polypeptide binding]; other site
340322001941 NADP binding site [chemical binding]; other site
340322001942 catalytic residues [active]
340322001943 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
340322001944 active site 2 [active]
340322001945 active site 1 [active]
340322001946 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
340322001947 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
340322001948 NAD binding site [chemical binding]; other site
340322001949 catalytic residues [active]
340322001950 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
340322001951 Zn2+ binding site [ion binding]; other site
340322001952 Mg2+ binding site [ion binding]; other site
340322001953 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
340322001954 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
340322001955 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
340322001956 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
340322001957 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
340322001958 catalytic loop [active]
340322001959 iron binding site [ion binding]; other site
340322001960 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
340322001961 classical (c) SDRs; Region: SDR_c; cd05233
340322001962 NAD(P) binding site [chemical binding]; other site
340322001963 active site
340322001964 hypothetical protein; Provisional; Region: PRK08296
340322001965 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
340322001966 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
340322001967 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
340322001968 Cytochrome P450; Region: p450; cl12078
340322001969 Transcriptional regulator [Transcription]; Region: IclR; COG1414
340322001970 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
340322001971 Bacterial transcriptional regulator; Region: IclR; pfam01614
340322001972 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
340322001973 SecY translocase; Region: SecY; pfam00344
340322001974 adenylate kinase; Reviewed; Region: adk; PRK00279
340322001975 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
340322001976 AMP-binding site [chemical binding]; other site
340322001977 ATP-AMP (Ap5A)-binding site [chemical binding]; other site
340322001978 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
340322001979 active site
340322001980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
340322001981 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
340322001982 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
340322001983 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
340322001984 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
340322001985 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
340322001986 Right handed beta helix region; Region: Beta_helix; pfam13229
340322001987 Right handed beta helix region; Region: Beta_helix; pfam13229
340322001988 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
340322001989 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
340322001990 NAD binding site [chemical binding]; other site
340322001991 homodimer interface [polypeptide binding]; other site
340322001992 active site
340322001993 substrate binding site [chemical binding]; other site
340322001994 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
340322001995 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
340322001996 DXD motif; other site
340322001997 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
340322001998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
340322001999 NAD(P) binding site [chemical binding]; other site
340322002000 active site
340322002001 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
340322002002 rRNA binding site [nucleotide binding]; other site
340322002003 predicted 30S ribosome binding site; other site
340322002004 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
340322002005 30S ribosomal protein S13; Region: bact_S13; TIGR03631
340322002006 30S ribosomal protein S11; Validated; Region: PRK05309
340322002007 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
340322002008 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
340322002009 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
340322002010 RNA binding surface [nucleotide binding]; other site
340322002011 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
340322002012 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
340322002013 alphaNTD - beta interaction site [polypeptide binding]; other site
340322002014 alphaNTD homodimer interface [polypeptide binding]; other site
340322002015 alphaNTD - beta' interaction site [polypeptide binding]; other site
340322002016 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
340322002017 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
340322002018 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
340322002019 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570
340322002020 dimerization interface 3.5A [polypeptide binding]; other site
340322002021 active site
340322002022 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
340322002023 Coenzyme A binding pocket [chemical binding]; other site
340322002024 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919
340322002025 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
340322002026 FAD binding domain; Region: FAD_binding_4; pfam01565
340322002027 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
340322002028 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
340322002029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340322002030 S-adenosylmethionine binding site [chemical binding]; other site
340322002031 TIGR02611 family protein; Region: TIGR02611
340322002032 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
340322002033 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
340322002034 active site
340322002035 catalytic residues [active]
340322002036 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
340322002037 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
340322002038 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
340322002039 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
340322002040 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
340322002041 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
340322002042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
340322002043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
340322002044 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
340322002045 23S rRNA interface [nucleotide binding]; other site
340322002046 L3 interface [polypeptide binding]; other site
340322002047 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
340322002048 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
340322002049 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
340322002050 active site
340322002051 substrate binding site [chemical binding]; other site
340322002052 metal binding site [ion binding]; metal-binding site
340322002053 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
340322002054 alanine racemase; Reviewed; Region: alr; PRK00053
340322002055 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
340322002056 active site
340322002057 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
340322002058 dimer interface [polypeptide binding]; other site
340322002059 substrate binding site [chemical binding]; other site
340322002060 catalytic residues [active]
340322002061 Predicted ATPase or kinase [General function prediction only]; Region: COG0802
340322002062 Predicted permease [General function prediction only]; Region: COG2985
340322002063 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
340322002064 TrkA-C domain; Region: TrkA_C; pfam02080
340322002065 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
340322002066 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
340322002067 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
340322002068 Glycoprotease family; Region: Peptidase_M22; pfam00814
340322002069 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
340322002070 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
340322002071 Coenzyme A binding pocket [chemical binding]; other site
340322002072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
340322002073 UGMP family protein; Validated; Region: PRK09604
340322002074 Uncharacterized conserved protein [Function unknown]; Region: COG0062
340322002075 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
340322002076 putative substrate binding site [chemical binding]; other site
340322002077 putative ATP binding site [chemical binding]; other site
340322002078 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
340322002079 oligomerisation interface [polypeptide binding]; other site
340322002080 mobile loop; other site
340322002081 roof hairpin; other site
340322002082 chaperonin GroEL; Reviewed; Region: groEL; PRK12849
340322002083 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
340322002084 ring oligomerisation interface [polypeptide binding]; other site
340322002085 ATP/Mg binding site [chemical binding]; other site
340322002086 stacking interactions; other site
340322002087 hinge regions; other site
340322002088 Transcription factor WhiB; Region: Whib; pfam02467
340322002089 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
340322002090 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
340322002091 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
340322002092 DNA binding residues [nucleotide binding]
340322002093 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
340322002094 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
340322002095 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
340322002096 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
340322002097 active site
340322002098 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
340322002099 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
340322002100 phosphate binding site [ion binding]; other site
340322002101 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
340322002102 EamA-like transporter family; Region: EamA; pfam00892
340322002103 Transcriptional regulator [Transcription]; Region: LysR; COG0583
340322002104 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
340322002105 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
340322002106 putative dimerization interface [polypeptide binding]; other site
340322002107 GMP synthase; Reviewed; Region: guaA; PRK00074
340322002108 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
340322002109 AMP/PPi binding site [chemical binding]; other site
340322002110 candidate oxyanion hole; other site
340322002111 catalytic triad [active]
340322002112 potential glutamine specificity residues [chemical binding]; other site
340322002113 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
340322002114 ATP Binding subdomain [chemical binding]; other site
340322002115 Ligand Binding sites [chemical binding]; other site
340322002116 Dimerization subdomain; other site
340322002117 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
340322002118 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
340322002119 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
340322002120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
340322002121 active site
340322002122 phosphorylation site [posttranslational modification]
340322002123 intermolecular recognition site; other site
340322002124 dimerization interface [polypeptide binding]; other site
340322002125 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
340322002126 dimerization interface [polypeptide binding]; other site
340322002127 DNA binding residues [nucleotide binding]
340322002128 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
340322002129 CT1975-like protein; Region: Cas_CT1975; pfam09344
340322002130 DNA Polymerase Y-family; Region: PolY_like; cd03468
340322002131 active site
340322002132 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
340322002133 DNA binding site [nucleotide binding]
340322002134 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
340322002135 putative dimer interface [polypeptide binding]; other site
340322002136 putative [2Fe-2S] cluster binding site [ion binding]; other site
340322002137 prenyltransferase; Reviewed; Region: ubiA; PRK13105
340322002138 UbiA prenyltransferase family; Region: UbiA; pfam01040
340322002139 phytoene desaturase; Region: crtI_fam; TIGR02734
340322002140 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
340322002141 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
340322002142 active site lid residues [active]
340322002143 substrate binding pocket [chemical binding]; other site
340322002144 catalytic residues [active]
340322002145 substrate-Mg2+ binding site; other site
340322002146 aspartate-rich region 1; other site
340322002147 aspartate-rich region 2; other site
340322002148 MMPL family; Region: MMPL; pfam03176
340322002149 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
340322002150 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
340322002151 substrate binding pocket [chemical binding]; other site
340322002152 chain length determination region; other site
340322002153 substrate-Mg2+ binding site; other site
340322002154 catalytic residues [active]
340322002155 aspartate-rich region 1; other site
340322002156 active site lid residues [active]
340322002157 aspartate-rich region 2; other site
340322002158 Transcriptional regulators [Transcription]; Region: MarR; COG1846
340322002159 MarR family; Region: MarR_2; pfam12802
340322002160 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
340322002161 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
340322002162 NAD(P) binding site [chemical binding]; other site
340322002163 active site
340322002164 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
340322002165 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
340322002166 DNA photolyase; Region: DNA_photolyase; pfam00875
340322002167 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
340322002168 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
340322002169 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
340322002170 Walker A/P-loop; other site
340322002171 ATP binding site [chemical binding]; other site
340322002172 Q-loop/lid; other site
340322002173 ABC transporter signature motif; other site
340322002174 Walker B; other site
340322002175 D-loop; other site
340322002176 H-loop/switch region; other site
340322002177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322002178 dimer interface [polypeptide binding]; other site
340322002179 conserved gate region; other site
340322002180 putative PBP binding loops; other site
340322002181 ABC-ATPase subunit interface; other site
340322002182 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
340322002183 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
340322002184 Walker A/P-loop; other site
340322002185 ATP binding site [chemical binding]; other site
340322002186 Q-loop/lid; other site
340322002187 ABC transporter signature motif; other site
340322002188 Walker B; other site
340322002189 D-loop; other site
340322002190 H-loop/switch region; other site
340322002191 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
340322002192 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
340322002193 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
340322002194 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
340322002195 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
340322002196 active site
340322002197 PHP Thumb interface [polypeptide binding]; other site
340322002198 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
340322002199 generic binding surface II; other site
340322002200 generic binding surface I; other site
340322002201 Uncharacterized conserved protein [Function unknown]; Region: COG3402
340322002202 Predicted membrane protein [Function unknown]; Region: COG3428
340322002203 Bacterial PH domain; Region: DUF304; pfam03703
340322002204 Bacterial PH domain; Region: DUF304; cl01348
340322002205 Bacterial PH domain; Region: DUF304; pfam03703
340322002206 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
340322002207 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
340322002208 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
340322002209 FeoA domain; Region: FeoA; pfam04023
340322002210 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
340322002211 NAD-dependent deacetylase; Provisional; Region: PRK00481
340322002212 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
340322002213 NAD+ binding site [chemical binding]; other site
340322002214 substrate binding site [chemical binding]; other site
340322002215 Zn binding site [ion binding]; other site
340322002216 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
340322002217 nucleoside/Zn binding site; other site
340322002218 dimer interface [polypeptide binding]; other site
340322002219 catalytic motif [active]
340322002220 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
340322002221 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
340322002222 siderophore binding site; other site
340322002223 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
340322002224 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
340322002225 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
340322002226 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
340322002227 homodimer interface [polypeptide binding]; other site
340322002228 NADP binding site [chemical binding]; other site
340322002229 substrate binding site [chemical binding]; other site
340322002230 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
340322002231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
340322002232 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399
340322002233 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
340322002234 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
340322002235 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
340322002236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322002237 metabolite-proton symporter; Region: 2A0106; TIGR00883
340322002238 putative substrate translocation pore; other site
340322002239 Transcriptional regulator [Transcription]; Region: LysR; COG0583
340322002240 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
340322002241 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
340322002242 putative substrate binding pocket [chemical binding]; other site
340322002243 dimerization interface [polypeptide binding]; other site
340322002244 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
340322002245 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
340322002246 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
340322002247 homotrimer interaction site [polypeptide binding]; other site
340322002248 putative active site [active]
340322002249 Family of unknown function (DUF1028); Region: DUF1028; pfam06267
340322002250 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
340322002251 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
340322002252 metal binding site [ion binding]; metal-binding site
340322002253 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
340322002254 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
340322002255 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613
340322002256 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
340322002257 homodimer interface [polypeptide binding]; other site
340322002258 substrate-cofactor binding pocket; other site
340322002259 pyridoxal 5'-phosphate binding site [chemical binding]; other site
340322002260 catalytic residue [active]
340322002261 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
340322002262 Carbon starvation protein CstA; Region: CstA; pfam02554
340322002263 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
340322002264 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
340322002265 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
340322002266 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
340322002267 tetramer interface [polypeptide binding]; other site
340322002268 active site
340322002269 Mg2+/Mn2+ binding site [ion binding]; other site
340322002270 citrate synthase; Provisional; Region: PRK14033
340322002271 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111
340322002272 dimer interface [polypeptide binding]; other site
340322002273 active site
340322002274 citrylCoA binding site [chemical binding]; other site
340322002275 oxalacetate/citrate binding site [chemical binding]; other site
340322002276 coenzyme A binding site [chemical binding]; other site
340322002277 catalytic triad [active]
340322002278 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
340322002279 Transcriptional regulators [Transcription]; Region: GntR; COG1802
340322002280 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
340322002281 DNA-binding site [nucleotide binding]; DNA binding site
340322002282 FCD domain; Region: FCD; pfam07729
340322002283 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
340322002284 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
340322002285 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
340322002286 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
340322002287 FAD binding pocket [chemical binding]; other site
340322002288 FAD binding motif [chemical binding]; other site
340322002289 phosphate binding motif [ion binding]; other site
340322002290 NAD binding pocket [chemical binding]; other site
340322002291 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
340322002292 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
340322002293 Walker A/P-loop; other site
340322002294 ATP binding site [chemical binding]; other site
340322002295 Q-loop/lid; other site
340322002296 ABC transporter signature motif; other site
340322002297 Walker B; other site
340322002298 D-loop; other site
340322002299 H-loop/switch region; other site
340322002300 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
340322002301 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
340322002302 ABC-ATPase subunit interface; other site
340322002303 dimer interface [polypeptide binding]; other site
340322002304 putative PBP binding regions; other site
340322002305 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
340322002306 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
340322002307 ABC-ATPase subunit interface; other site
340322002308 dimer interface [polypeptide binding]; other site
340322002309 putative PBP binding regions; other site
340322002310 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
340322002311 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
340322002312 siderophore binding site; other site
340322002313 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
340322002314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322002315 putative substrate translocation pore; other site
340322002316 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
340322002317 putative catalytic site [active]
340322002318 putative metal binding site [ion binding]; other site
340322002319 putative phosphate binding site [ion binding]; other site
340322002320 Predicted membrane protein [Function unknown]; Region: COG2860
340322002321 UPF0126 domain; Region: UPF0126; pfam03458
340322002322 UPF0126 domain; Region: UPF0126; pfam03458
340322002323 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
340322002324 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
340322002325 intersubunit interface [polypeptide binding]; other site
340322002326 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
340322002327 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
340322002328 Walker A/P-loop; other site
340322002329 ATP binding site [chemical binding]; other site
340322002330 Q-loop/lid; other site
340322002331 ABC transporter signature motif; other site
340322002332 Walker B; other site
340322002333 D-loop; other site
340322002334 H-loop/switch region; other site
340322002335 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
340322002336 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
340322002337 ABC-ATPase subunit interface; other site
340322002338 dimer interface [polypeptide binding]; other site
340322002339 putative PBP binding regions; other site
340322002340 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
340322002341 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
340322002342 active site
340322002343 HIGH motif; other site
340322002344 dimer interface [polypeptide binding]; other site
340322002345 KMSKS motif; other site
340322002346 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
340322002347 RDD family; Region: RDD; pfam06271
340322002348 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
340322002349 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
340322002350 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
340322002351 NlpC/P60 family; Region: NLPC_P60; pfam00877
340322002352 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
340322002353 active site
340322002354 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
340322002355 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340322002356 non-specific DNA binding site [nucleotide binding]; other site
340322002357 salt bridge; other site
340322002358 sequence-specific DNA binding site [nucleotide binding]; other site
340322002359 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
340322002360 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
340322002361 active site
340322002362 substrate binding site [chemical binding]; other site
340322002363 metal binding site [ion binding]; metal-binding site
340322002364 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
340322002365 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
340322002366 metal binding site [ion binding]; metal-binding site
340322002367 putative dimer interface [polypeptide binding]; other site
340322002368 flavoprotein disulfide reductase; Reviewed; Region: PRK07845
340322002369 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
340322002370 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
340322002371 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
340322002372 pyruvate carboxylase; Reviewed; Region: PRK12999
340322002373 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
340322002374 ATP-grasp domain; Region: ATP-grasp_4; cl17255
340322002375 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
340322002376 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
340322002377 active site
340322002378 catalytic residues [active]
340322002379 metal binding site [ion binding]; metal-binding site
340322002380 homodimer binding site [polypeptide binding]; other site
340322002381 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
340322002382 carboxyltransferase (CT) interaction site; other site
340322002383 biotinylation site [posttranslational modification]; other site
340322002384 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
340322002385 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
340322002386 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
340322002387 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
340322002388 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
340322002389 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
340322002390 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
340322002391 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
340322002392 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
340322002393 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
340322002394 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
340322002395 tetramer interface [polypeptide binding]; other site
340322002396 active site
340322002397 Mg2+/Mn2+ binding site [ion binding]; other site
340322002398 citrate synthase; Provisional; Region: PRK14033
340322002399 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111
340322002400 dimer interface [polypeptide binding]; other site
340322002401 active site
340322002402 citrylCoA binding site [chemical binding]; other site
340322002403 oxalacetate/citrate binding site [chemical binding]; other site
340322002404 coenzyme A binding site [chemical binding]; other site
340322002405 catalytic triad [active]
340322002406 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
340322002407 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340322002408 non-specific DNA binding site [nucleotide binding]; other site
340322002409 salt bridge; other site
340322002410 sequence-specific DNA binding site [nucleotide binding]; other site
340322002411 Predicted transcriptional regulator [General function prediction only]; Region: COG3800
340322002412 Domain of unknown function (DUF955); Region: DUF955; pfam06114
340322002413 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
340322002414 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
340322002415 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
340322002416 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
340322002417 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
340322002418 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
340322002419 carboxyltransferase (CT) interaction site; other site
340322002420 biotinylation site [posttranslational modification]; other site
340322002421 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
340322002422 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
340322002423 active site residue [active]
340322002424 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
340322002425 active site residue [active]
340322002426 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
340322002427 Predicted acyltransferases [Lipid metabolism]; Region: COG1835
340322002428 Maf-like protein; Region: Maf; pfam02545
340322002429 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
340322002430 active site
340322002431 dimer interface [polypeptide binding]; other site
340322002432 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822
340322002433 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
340322002434 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
340322002435 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
340322002436 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
340322002437 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
340322002438 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
340322002439 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
340322002440 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
340322002441 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
340322002442 ATP-grasp domain; Region: ATP-grasp; pfam02222
340322002443 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
340322002444 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
340322002445 Uncharacterized conserved protein [Function unknown]; Region: COG1434
340322002446 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
340322002447 putative active site [active]
340322002448 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
340322002449 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
340322002450 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
340322002451 active site
340322002452 non-prolyl cis peptide bond; other site
340322002453 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642
340322002454 putative beta-ketoacyl acyl carrier protein [ACP]reductase (BKR), subgroup 2, classical (c) SDR; Region: BKR_2_SDR_c; cd05349
340322002455 putative NAD(P) binding site [chemical binding]; other site
340322002456 active site
340322002457 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
340322002458 RibD C-terminal domain; Region: RibD_C; cl17279
340322002459 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353
340322002460 putative dimer interface [polypeptide binding]; other site
340322002461 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
340322002462 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
340322002463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322002464 dimer interface [polypeptide binding]; other site
340322002465 conserved gate region; other site
340322002466 putative PBP binding loops; other site
340322002467 ABC-ATPase subunit interface; other site
340322002468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322002469 dimer interface [polypeptide binding]; other site
340322002470 conserved gate region; other site
340322002471 putative PBP binding loops; other site
340322002472 ABC-ATPase subunit interface; other site
340322002473 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901
340322002474 putative hydrophobic ligand binding site [chemical binding]; other site
340322002475 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
340322002476 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
340322002477 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
340322002478 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
340322002479 Walker A/P-loop; other site
340322002480 ATP binding site [chemical binding]; other site
340322002481 Q-loop/lid; other site
340322002482 ABC transporter signature motif; other site
340322002483 Walker B; other site
340322002484 D-loop; other site
340322002485 H-loop/switch region; other site
340322002486 TOBE domain; Region: TOBE_2; pfam08402
340322002487 TIGR03089 family protein; Region: TIGR03089
340322002488 Transcriptional regulator [Transcription]; Region: LytR; COG1316
340322002489 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
340322002490 Predicted glycosyltransferases [General function prediction only]; Region: COG1216
340322002491 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
340322002492 Probable Catalytic site; other site
340322002493 metal-binding site
340322002494 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
340322002495 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
340322002496 active site
340322002497 Substrate binding site; other site
340322002498 Mg++ binding site; other site
340322002499 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
340322002500 putative trimer interface [polypeptide binding]; other site
340322002501 putative CoA binding site [chemical binding]; other site
340322002502 Transcription factor WhiB; Region: Whib; pfam02467
340322002503 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
340322002504 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
340322002505 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
340322002506 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
340322002507 active site
340322002508 substrate binding site [chemical binding]; other site
340322002509 metal binding site [ion binding]; metal-binding site
340322002510 mannose-6-phosphate isomerase; Provisional; Region: PRK15131
340322002511 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
340322002512 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
340322002513 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
340322002514 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
340322002515 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
340322002516 homotetramer interface [polypeptide binding]; other site
340322002517 ligand binding site [chemical binding]; other site
340322002518 catalytic site [active]
340322002519 NAD binding site [chemical binding]; other site
340322002520 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
340322002521 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
340322002522 TMP-binding site; other site
340322002523 ATP-binding site [chemical binding]; other site
340322002524 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
340322002525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
340322002526 active site
340322002527 phosphorylation site [posttranslational modification]
340322002528 intermolecular recognition site; other site
340322002529 dimerization interface [polypeptide binding]; other site
340322002530 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
340322002531 DNA binding site [nucleotide binding]
340322002532 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
340322002533 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
340322002534 dimerization interface [polypeptide binding]; other site
340322002535 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
340322002536 dimer interface [polypeptide binding]; other site
340322002537 phosphorylation site [posttranslational modification]
340322002538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
340322002539 ATP binding site [chemical binding]; other site
340322002540 Mg2+ binding site [ion binding]; other site
340322002541 G-X-G motif; other site
340322002542 lipoprotein LpqB; Provisional; Region: PRK13616
340322002543 Sporulation and spore germination; Region: Germane; pfam10646
340322002544 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
340322002545 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
340322002546 active site
340322002547 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
340322002548 30S subunit binding site; other site
340322002549 preprotein translocase subunit SecA; Reviewed; Region: PRK12904
340322002550 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
340322002551 ATP binding site [chemical binding]; other site
340322002552 putative Mg++ binding site [ion binding]; other site
340322002553 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
340322002554 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
340322002555 nucleotide binding region [chemical binding]; other site
340322002556 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
340322002557 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
340322002558 Predicted GTPases [General function prediction only]; Region: COG1162
340322002559 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
340322002560 GTPase/Zn-binding domain interface [polypeptide binding]; other site
340322002561 GTP/Mg2+ binding site [chemical binding]; other site
340322002562 G4 box; other site
340322002563 G1 box; other site
340322002564 Switch I region; other site
340322002565 G2 box; other site
340322002566 G3 box; other site
340322002567 Switch II region; other site
340322002568 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
340322002569 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
340322002570 hinge; other site
340322002571 active site
340322002572 Uncharacterized conserved protein [Function unknown]; Region: COG2135
340322002573 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
340322002574 active site
340322002575 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
340322002576 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
340322002577 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
340322002578 DNA binding residues [nucleotide binding]
340322002579 Transcription factor WhiB; Region: Whib; pfam02467
340322002580 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268
340322002581 DEAD-like helicases superfamily; Region: DEXDc; smart00487
340322002582 ATP binding site [chemical binding]; other site
340322002583 Mg++ binding site [ion binding]; other site
340322002584 motif III; other site
340322002585 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
340322002586 nucleotide binding region [chemical binding]; other site
340322002587 ATP-binding site [chemical binding]; other site
340322002588 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
340322002589 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350
340322002590 TIGR02569 family protein; Region: TIGR02569_actnb
340322002591 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
340322002592 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
340322002593 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
340322002594 Family description; Region: UvrD_C_2; pfam13538
340322002595 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
340322002596 Ion channel; Region: Ion_trans_2; pfam07885
340322002597 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
340322002598 TrkA-N domain; Region: TrkA_N; pfam02254
340322002599 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
340322002600 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
340322002601 putative NADH binding site [chemical binding]; other site
340322002602 putative active site [active]
340322002603 nudix motif; other site
340322002604 putative metal binding site [ion binding]; other site
340322002605 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
340322002606 Part of AAA domain; Region: AAA_19; pfam13245
340322002607 Family description; Region: UvrD_C_2; pfam13538
340322002608 HRDC domain; Region: HRDC; pfam00570
340322002609 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
340322002610 Uncharacterized conserved protein [Function unknown]; Region: COG5282
340322002611 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
340322002612 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
340322002613 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
340322002614 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
340322002615 hypothetical protein; Validated; Region: PRK00068
340322002616 Uncharacterized conserved protein [Function unknown]; Region: COG1615
340322002617 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
340322002618 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
340322002619 DNA-binding site [nucleotide binding]; DNA binding site
340322002620 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
340322002621 pyridoxal 5'-phosphate binding site [chemical binding]; other site
340322002622 homodimer interface [polypeptide binding]; other site
340322002623 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
340322002624 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
340322002625 active site
340322002626 multimer interface [polypeptide binding]; other site
340322002627 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
340322002628 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118
340322002629 predicted active site [active]
340322002630 catalytic triad [active]
340322002631 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
340322002632 substrate binding sites [chemical binding]; other site
340322002633 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
340322002634 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
340322002635 active site
340322002636 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
340322002637 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
340322002638 active site
340322002639 peptide chain release factor 2; Validated; Region: prfB; PRK00578
340322002640 This domain is found in peptide chain release factors; Region: PCRF; smart00937
340322002641 RF-1 domain; Region: RF-1; pfam00472
340322002642 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
340322002643 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322002644 Walker A/P-loop; other site
340322002645 ATP binding site [chemical binding]; other site
340322002646 Q-loop/lid; other site
340322002647 ABC transporter signature motif; other site
340322002648 Walker B; other site
340322002649 D-loop; other site
340322002650 H-loop/switch region; other site
340322002651 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
340322002652 FtsX-like permease family; Region: FtsX; pfam02687
340322002653 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
340322002654 SmpB-tmRNA interface; other site
340322002655 Uncharacterized conserved protein [Function unknown]; Region: COG3189
340322002656 cytidine deaminase; Validated; Region: PRK08298
340322002657 active site
340322002658 Zn binding site [ion binding]; other site
340322002659 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
340322002660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322002661 dimer interface [polypeptide binding]; other site
340322002662 conserved gate region; other site
340322002663 putative PBP binding loops; other site
340322002664 ABC-ATPase subunit interface; other site
340322002665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322002666 dimer interface [polypeptide binding]; other site
340322002667 conserved gate region; other site
340322002668 putative PBP binding loops; other site
340322002669 ABC-ATPase subunit interface; other site
340322002670 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
340322002671 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
340322002672 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
340322002673 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
340322002674 Walker A/P-loop; other site
340322002675 ATP binding site [chemical binding]; other site
340322002676 Q-loop/lid; other site
340322002677 ABC transporter signature motif; other site
340322002678 Walker B; other site
340322002679 D-loop; other site
340322002680 H-loop/switch region; other site
340322002681 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
340322002682 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
340322002683 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
340322002684 cofactor binding site; other site
340322002685 DNA binding site [nucleotide binding]
340322002686 substrate interaction site [chemical binding]; other site
340322002687 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
340322002688 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
340322002689 FAD binding pocket [chemical binding]; other site
340322002690 FAD binding motif [chemical binding]; other site
340322002691 phosphate binding motif [ion binding]; other site
340322002692 NAD binding pocket [chemical binding]; other site
340322002693 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
340322002694 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
340322002695 siderophore binding site; other site
340322002696 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
340322002697 putative active site [active]
340322002698 redox center [active]
340322002699 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
340322002700 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
340322002701 intersubunit interface [polypeptide binding]; other site
340322002702 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
340322002703 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
340322002704 ABC-ATPase subunit interface; other site
340322002705 dimer interface [polypeptide binding]; other site
340322002706 putative PBP binding regions; other site
340322002707 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
340322002708 ABC-ATPase subunit interface; other site
340322002709 dimer interface [polypeptide binding]; other site
340322002710 putative PBP binding regions; other site
340322002711 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
340322002712 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
340322002713 Walker A/P-loop; other site
340322002714 ATP binding site [chemical binding]; other site
340322002715 Q-loop/lid; other site
340322002716 ABC transporter signature motif; other site
340322002717 Walker B; other site
340322002718 D-loop; other site
340322002719 H-loop/switch region; other site
340322002720 aminotransferase; Validated; Region: PRK07777
340322002721 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
340322002722 pyridoxal 5'-phosphate binding site [chemical binding]; other site
340322002723 homodimer interface [polypeptide binding]; other site
340322002724 catalytic residue [active]
340322002725 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580
340322002726 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
340322002727 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
340322002728 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
340322002729 ATP binding site [chemical binding]; other site
340322002730 putative Mg++ binding site [ion binding]; other site
340322002731 helicase superfamily c-terminal domain; Region: HELICc; smart00490
340322002732 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
340322002733 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
340322002734 DNA-binding site [nucleotide binding]; DNA binding site
340322002735 RNA-binding motif; other site
340322002736 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969
340322002737 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
340322002738 substrate-cofactor binding pocket; other site
340322002739 homodimer interface [polypeptide binding]; other site
340322002740 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
340322002741 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
340322002742 pyridoxal 5'-phosphate binding site [chemical binding]; other site
340322002743 catalytic residue [active]
340322002744 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252
340322002745 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
340322002746 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
340322002747 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
340322002748 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
340322002749 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366
340322002750 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
340322002751 catalytic residue [active]
340322002752 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
340322002753 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
340322002754 dimer interface [polypeptide binding]; other site
340322002755 active site
340322002756 citrylCoA binding site [chemical binding]; other site
340322002757 NADH binding [chemical binding]; other site
340322002758 cationic pore residues; other site
340322002759 oxalacetate/citrate binding site [chemical binding]; other site
340322002760 coenzyme A binding site [chemical binding]; other site
340322002761 catalytic triad [active]
340322002762 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
340322002763 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
340322002764 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777
340322002765 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
340322002766 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
340322002767 Predicted membrane protein [Function unknown]; Region: COG3162
340322002768 Predicted symporter [General function prediction only]; Region: DhlC; COG4147
340322002769 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
340322002770 Na binding site [ion binding]; other site
340322002771 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
340322002772 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
340322002773 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
340322002774 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
340322002775 phosphate binding site [ion binding]; other site
340322002776 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
340322002777 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
340322002778 active site 2 [active]
340322002779 active site 1 [active]
340322002780 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
340322002781 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
340322002782 3-oxoacyl-[acyl-carrier protein]; Region: COG4982
340322002783 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
340322002784 putative NAD(P) binding site [chemical binding]; other site
340322002785 active site
340322002786 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
340322002787 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
340322002788 active site
340322002789 Septum formation; Region: Septum_form; pfam13845
340322002790 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
340322002791 hypothetical protein; Validated; Region: PRK07581
340322002792 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
340322002793 catalytic residues [active]
340322002794 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
340322002795 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
340322002796 folate binding site [chemical binding]; other site
340322002797 NADP+ binding site [chemical binding]; other site
340322002798 thymidylate synthase; Reviewed; Region: thyA; PRK01827
340322002799 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
340322002800 dimerization interface [polypeptide binding]; other site
340322002801 active site
340322002802 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
340322002803 active site
340322002804 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
340322002805 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
340322002806 ATP binding site [chemical binding]; other site
340322002807 putative Mg++ binding site [ion binding]; other site
340322002808 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
340322002809 nucleotide binding region [chemical binding]; other site
340322002810 ATP-binding site [chemical binding]; other site
340322002811 DEAD/H associated; Region: DEAD_assoc; pfam08494
340322002812 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
340322002813 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
340322002814 putative DNA binding site [nucleotide binding]; other site
340322002815 catalytic residue [active]
340322002816 putative H2TH interface [polypeptide binding]; other site
340322002817 putative catalytic residues [active]
340322002818 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
340322002819 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
340322002820 Predicted membrane protein [Function unknown]; Region: COG3304
340322002821 Domain of unknown function (DUF307); Region: DUF307; pfam03733
340322002822 Domain of unknown function (DUF307); Region: DUF307; pfam03733
340322002823 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
340322002824 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
340322002825 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
340322002826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322002827 putative substrate translocation pore; other site
340322002828 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
340322002829 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
340322002830 active site
340322002831 dimer interface [polypeptide binding]; other site
340322002832 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
340322002833 dimer interface [polypeptide binding]; other site
340322002834 active site
340322002835 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
340322002836 active site
340322002837 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
340322002838 Part of AAA domain; Region: AAA_19; pfam13245
340322002839 Family description; Region: UvrD_C_2; pfam13538
340322002840 FtsX-like permease family; Region: FtsX; pfam02687
340322002841 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
340322002842 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
340322002843 Walker A/P-loop; other site
340322002844 ATP binding site [chemical binding]; other site
340322002845 Q-loop/lid; other site
340322002846 ABC transporter signature motif; other site
340322002847 Walker B; other site
340322002848 D-loop; other site
340322002849 H-loop/switch region; other site
340322002850 Predicted transcriptional regulators [Transcription]; Region: COG1695
340322002851 Transcriptional regulator PadR-like family; Region: PadR; cl17335
340322002852 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
340322002853 Peptidase family M23; Region: Peptidase_M23; pfam01551
340322002854 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
340322002855 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
340322002856 active site
340322002857 substrate binding site [chemical binding]; other site
340322002858 cosubstrate binding site; other site
340322002859 catalytic site [active]
340322002860 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
340322002861 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421
340322002862 purine monophosphate binding site [chemical binding]; other site
340322002863 dimer interface [polypeptide binding]; other site
340322002864 putative catalytic residues [active]
340322002865 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
340322002866 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
340322002867 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
340322002868 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
340322002869 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
340322002870 30S ribosomal protein S18; Provisional; Region: PRK13401
340322002871 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
340322002872 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
340322002873 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
340322002874 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
340322002875 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
340322002876 Sulfate transporter family; Region: Sulfate_transp; pfam00916
340322002877 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
340322002878 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
340322002879 dimerization interface [polypeptide binding]; other site
340322002880 putative DNA binding site [nucleotide binding]; other site
340322002881 putative Zn2+ binding site [ion binding]; other site
340322002882 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
340322002883 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
340322002884 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
340322002885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
340322002886 active site
340322002887 phosphorylation site [posttranslational modification]
340322002888 intermolecular recognition site; other site
340322002889 dimerization interface [polypeptide binding]; other site
340322002890 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
340322002891 DNA binding site [nucleotide binding]
340322002892 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
340322002893 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
340322002894 dimerization interface [polypeptide binding]; other site
340322002895 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
340322002896 dimer interface [polypeptide binding]; other site
340322002897 phosphorylation site [posttranslational modification]
340322002898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
340322002899 ATP binding site [chemical binding]; other site
340322002900 Mg2+ binding site [ion binding]; other site
340322002901 G-X-G motif; other site
340322002902 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
340322002903 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
340322002904 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
340322002905 protein binding site [polypeptide binding]; other site
340322002906 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
340322002907 MPT binding site; other site
340322002908 trimer interface [polypeptide binding]; other site
340322002909 ADDz for ATRX, Dnmt3 and Dnmt3l PHD-like zinc finger domain; Region: ADDz; cl17040
340322002910 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
340322002911 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
340322002912 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
340322002913 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
340322002914 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
340322002915 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
340322002916 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
340322002917 active site
340322002918 tetramer interface; other site
340322002919 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
340322002920 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
340322002921 dimer interface [polypeptide binding]; other site
340322002922 putative functional site; other site
340322002923 putative MPT binding site; other site
340322002924 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
340322002925 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
340322002926 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
340322002927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322002928 putative substrate translocation pore; other site
340322002929 Predicted membrane protein [Function unknown]; Region: COG2259
340322002930 Predicted integral membrane protein [Function unknown]; Region: COG5660
340322002931 Putative zinc-finger; Region: zf-HC2; pfam13490
340322002932 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354
340322002933 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
340322002934 active site
340322002935 catalytic site [active]
340322002936 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
340322002937 Predicted methyltransferases [General function prediction only]; Region: COG0313
340322002938 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
340322002939 putative SAM binding site [chemical binding]; other site
340322002940 putative homodimer interface [polypeptide binding]; other site
340322002941 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
340322002942 methionyl-tRNA synthetase; Reviewed; Region: PRK12268
340322002943 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
340322002944 active site
340322002945 HIGH motif; other site
340322002946 KMSKS motif; other site
340322002947 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
340322002948 tRNA binding surface [nucleotide binding]; other site
340322002949 anticodon binding site; other site
340322002950 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
340322002951 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
340322002952 ATP binding site [chemical binding]; other site
340322002953 putative Mg++ binding site [ion binding]; other site
340322002954 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
340322002955 nucleotide binding region [chemical binding]; other site
340322002956 ATP-binding site [chemical binding]; other site
340322002957 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
340322002958 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
340322002959 active site
340322002960 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
340322002961 Domain of unknown function (DUF348); Region: DUF348; pfam03990
340322002962 Domain of unknown function (DUF348); Region: DUF348; pfam03990
340322002963 G5 domain; Region: G5; pfam07501
340322002964 Transglycosylase-like domain; Region: Transglycosylas; pfam06737
340322002965 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
340322002966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340322002967 S-adenosylmethionine binding site [chemical binding]; other site
340322002968 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
340322002969 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
340322002970 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
340322002971 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
340322002972 ABC transporter; Region: ABC_tran_2; pfam12848
340322002973 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
340322002974 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
340322002975 dimer interface [polypeptide binding]; other site
340322002976 pyridoxal binding site [chemical binding]; other site
340322002977 ATP binding site [chemical binding]; other site
340322002978 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
340322002979 Thioredoxin-like; Region: Thioredoxin_8; pfam13905
340322002980 catalytic residues [active]
340322002981 Uncharacterized conserved protein [Function unknown]; Region: COG1359
340322002982 Uncharacterized conserved protein [Function unknown]; Region: COG1359
340322002983 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
340322002984 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
340322002985 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
340322002986 active site
340322002987 motif I; other site
340322002988 motif II; other site
340322002989 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
340322002990 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
340322002991 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
340322002992 substrate binding site [chemical binding]; other site
340322002993 oxyanion hole (OAH) forming residues; other site
340322002994 trimer interface [polypeptide binding]; other site
340322002995 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
340322002996 Predicted membrane protein [General function prediction only]; Region: COG4194
340322002997 Predicted esterase [General function prediction only]; Region: COG0627
340322002998 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
340322002999 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
340322003000 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
340322003001 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
340322003002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4899
340322003003 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
340322003004 active site
340322003005 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
340322003006 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
340322003007 G1 box; other site
340322003008 putative GEF interaction site [polypeptide binding]; other site
340322003009 GTP/Mg2+ binding site [chemical binding]; other site
340322003010 Switch I region; other site
340322003011 G2 box; other site
340322003012 G3 box; other site
340322003013 Switch II region; other site
340322003014 G4 box; other site
340322003015 G5 box; other site
340322003016 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
340322003017 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
340322003018 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
340322003019 putative ligand binding site [chemical binding]; other site
340322003020 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
340322003021 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
340322003022 TM-ABC transporter signature motif; other site
340322003023 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
340322003024 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
340322003025 TM-ABC transporter signature motif; other site
340322003026 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
340322003027 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
340322003028 Walker A/P-loop; other site
340322003029 ATP binding site [chemical binding]; other site
340322003030 Q-loop/lid; other site
340322003031 ABC transporter signature motif; other site
340322003032 Walker B; other site
340322003033 D-loop; other site
340322003034 H-loop/switch region; other site
340322003035 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
340322003036 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
340322003037 Walker A/P-loop; other site
340322003038 ATP binding site [chemical binding]; other site
340322003039 Q-loop/lid; other site
340322003040 ABC transporter signature motif; other site
340322003041 Walker B; other site
340322003042 D-loop; other site
340322003043 H-loop/switch region; other site
340322003044 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
340322003045 putative active site [active]
340322003046 catalytic residue [active]
340322003047 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
340322003048 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
340322003049 FMN binding site [chemical binding]; other site
340322003050 substrate binding site [chemical binding]; other site
340322003051 putative catalytic residue [active]
340322003052 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
340322003053 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
340322003054 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
340322003055 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
340322003056 putative active site [active]
340322003057 catalytic residue [active]
340322003058 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
340322003059 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
340322003060 5S rRNA interface [nucleotide binding]; other site
340322003061 CTC domain interface [polypeptide binding]; other site
340322003062 L16 interface [polypeptide binding]; other site
340322003063 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
340322003064 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
340322003065 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
340322003066 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
340322003067 active site
340322003068 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
340322003069 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
340322003070 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
340322003071 active site
340322003072 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
340322003073 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
340322003074 Substrate binding site; other site
340322003075 Mg++ binding site; other site
340322003076 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
340322003077 active site
340322003078 substrate binding site [chemical binding]; other site
340322003079 CoA binding site [chemical binding]; other site
340322003080 Major Facilitator Superfamily; Region: MFS_1; pfam07690
340322003081 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
340322003082 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
340322003083 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
340322003084 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
340322003085 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
340322003086 Walker A/P-loop; other site
340322003087 ATP binding site [chemical binding]; other site
340322003088 Q-loop/lid; other site
340322003089 ABC transporter signature motif; other site
340322003090 Walker B; other site
340322003091 D-loop; other site
340322003092 H-loop/switch region; other site
340322003093 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
340322003094 Histidine kinase; Region: HisKA_3; pfam07730
340322003095 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
340322003096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
340322003097 active site
340322003098 phosphorylation site [posttranslational modification]
340322003099 intermolecular recognition site; other site
340322003100 dimerization interface [polypeptide binding]; other site
340322003101 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
340322003102 DNA binding residues [nucleotide binding]
340322003103 dimerization interface [polypeptide binding]; other site
340322003104 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
340322003105 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
340322003106 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
340322003107 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322003108 ABC transporter signature motif; other site
340322003109 Walker B; other site
340322003110 D-loop; other site
340322003111 H-loop/switch region; other site
340322003112 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
340322003113 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
340322003114 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322003115 Walker A/P-loop; other site
340322003116 ATP binding site [chemical binding]; other site
340322003117 Q-loop/lid; other site
340322003118 ABC transporter signature motif; other site
340322003119 Walker B; other site
340322003120 D-loop; other site
340322003121 H-loop/switch region; other site
340322003122 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
340322003123 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
340322003124 Excalibur calcium-binding domain; Region: Excalibur; pfam05901
340322003125 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
340322003126 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
340322003127 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
340322003128 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
340322003129 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
340322003130 ATP binding site [chemical binding]; other site
340322003131 putative Mg++ binding site [ion binding]; other site
340322003132 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
340322003133 nucleotide binding region [chemical binding]; other site
340322003134 ATP-binding site [chemical binding]; other site
340322003135 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
340322003136 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
340322003137 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
340322003138 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
340322003139 Walker A/P-loop; other site
340322003140 ATP binding site [chemical binding]; other site
340322003141 Q-loop/lid; other site
340322003142 ABC transporter signature motif; other site
340322003143 Walker B; other site
340322003144 D-loop; other site
340322003145 H-loop/switch region; other site
340322003146 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
340322003147 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
340322003148 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322003149 Walker A/P-loop; other site
340322003150 ATP binding site [chemical binding]; other site
340322003151 Q-loop/lid; other site
340322003152 ABC transporter signature motif; other site
340322003153 Walker B; other site
340322003154 D-loop; other site
340322003155 H-loop/switch region; other site
340322003156 Uncharacterized conserved protein [Function unknown]; Region: COG2898
340322003157 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
340322003158 Predicted esterase [General function prediction only]; Region: COG0627
340322003159 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
340322003160 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
340322003161 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
340322003162 homodimer interface [polypeptide binding]; other site
340322003163 metal binding site [ion binding]; metal-binding site
340322003164 Alpha helical Porin B; Region: PorB; pfam11565
340322003165 Alpha helical Porin B; Region: PorB; pfam11565
340322003166 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
340322003167 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254
340322003168 N-acetyl-D-glucosamine binding site [chemical binding]; other site
340322003169 enolase; Provisional; Region: eno; PRK00077
340322003170 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
340322003171 dimer interface [polypeptide binding]; other site
340322003172 metal binding site [ion binding]; metal-binding site
340322003173 substrate binding pocket [chemical binding]; other site
340322003174 Septum formation initiator; Region: DivIC; pfam04977
340322003175 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
340322003176 Uncharacterized conserved protein [Function unknown]; Region: COG1507
340322003177 exopolyphosphatase; Region: exo_poly_only; TIGR03706
340322003178 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
340322003179 Predicted transcriptional regulator [Transcription]; Region: COG1395
340322003180 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
340322003181 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
340322003182 Predicted membrane protein [Function unknown]; Region: COG4760
340322003183 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
340322003184 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
340322003185 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
340322003186 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
340322003187 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446
340322003188 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
340322003189 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
340322003190 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14828
340322003191 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
340322003192 catalytic residue [active]
340322003193 putative FPP diphosphate binding site; other site
340322003194 putative FPP binding hydrophobic cleft; other site
340322003195 dimer interface [polypeptide binding]; other site
340322003196 putative IPP diphosphate binding site; other site
340322003197 Flavodoxin domain; Region: Flavodoxin_5; pfam12724
340322003198 pantothenate kinase; Provisional; Region: PRK05439
340322003199 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
340322003200 ATP-binding site [chemical binding]; other site
340322003201 CoA-binding site [chemical binding]; other site
340322003202 Mg2+-binding site [ion binding]; other site
340322003203 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
340322003204 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
340322003205 dimer interface [polypeptide binding]; other site
340322003206 active site
340322003207 glycine-pyridoxal phosphate binding site [chemical binding]; other site
340322003208 folate binding site [chemical binding]; other site
340322003209 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
340322003210 Glutamine amidotransferase class-I; Region: GATase; pfam00117
340322003211 glutamine binding [chemical binding]; other site
340322003212 catalytic triad [active]
340322003213 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
340322003214 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824
340322003215 chorismate binding enzyme; Region: Chorismate_bind; cl10555
340322003216 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
340322003217 substrate-cofactor binding pocket; other site
340322003218 homodimer interface [polypeptide binding]; other site
340322003219 Aminotransferase class IV; Region: Aminotran_4; pfam01063
340322003220 pyridoxal 5'-phosphate binding site [chemical binding]; other site
340322003221 catalytic residue [active]
340322003222 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
340322003223 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
340322003224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
340322003225 Coenzyme A binding pocket [chemical binding]; other site
340322003226 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
340322003227 Allophanate hydrolase subunit 1; Region: AHS1; smart00796
340322003228 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
340322003229 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787
340322003230 putative active site [active]
340322003231 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
340322003232 Transcriptional regulators [Transcription]; Region: FadR; COG2186
340322003233 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
340322003234 DNA-binding site [nucleotide binding]; DNA binding site
340322003235 FCD domain; Region: FCD; pfam07729
340322003236 fumarate hydratase; Reviewed; Region: fumC; PRK00485
340322003237 Class II fumarases; Region: Fumarase_classII; cd01362
340322003238 active site
340322003239 tetramer interface [polypeptide binding]; other site
340322003240 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
340322003241 Predicted flavoprotein [General function prediction only]; Region: COG0431
340322003242 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
340322003243 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
340322003244 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
340322003245 putative active site [active]
340322003246 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
340322003247 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
340322003248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322003249 putative substrate translocation pore; other site
340322003250 Transcriptional regulators [Transcription]; Region: MarR; COG1846
340322003251 MarR family; Region: MarR_2; pfam12802
340322003252 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
340322003253 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
340322003254 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
340322003255 generic binding surface II; other site
340322003256 generic binding surface I; other site
340322003257 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
340322003258 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
340322003259 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
340322003260 Membrane protein of unknown function; Region: DUF360; pfam04020
340322003261 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
340322003262 Domain of unknown function DUF20; Region: UPF0118; pfam01594
340322003263 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
340322003264 Na2 binding site [ion binding]; other site
340322003265 putative substrate binding site 1 [chemical binding]; other site
340322003266 Na binding site 1 [ion binding]; other site
340322003267 putative substrate binding site 2 [chemical binding]; other site
340322003268 Putative esterase; Region: Esterase; pfam00756
340322003269 GTP-binding protein YchF; Reviewed; Region: PRK09601
340322003270 YchF GTPase; Region: YchF; cd01900
340322003271 G1 box; other site
340322003272 GTP/Mg2+ binding site [chemical binding]; other site
340322003273 Switch I region; other site
340322003274 G2 box; other site
340322003275 Switch II region; other site
340322003276 G3 box; other site
340322003277 G4 box; other site
340322003278 G5 box; other site
340322003279 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
340322003280 short chain dehydrogenase; Validated; Region: PRK06182
340322003281 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
340322003282 NADP binding site [chemical binding]; other site
340322003283 active site
340322003284 steroid binding site; other site
340322003285 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
340322003286 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
340322003287 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
340322003288 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
340322003289 MASE1; Region: MASE1; pfam05231
340322003290 PAS domain S-box; Region: sensory_box; TIGR00229
340322003291 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
340322003292 putative active site [active]
340322003293 heme pocket [chemical binding]; other site
340322003294 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199
340322003295 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
340322003296 metal binding site [ion binding]; metal-binding site
340322003297 active site
340322003298 I-site; other site
340322003299 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
340322003300 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
340322003301 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423
340322003302 DXD motif; other site
340322003303 NNMT/PNMT/TEMT family; Region: NNMT_PNMT_TEMT; pfam01234
340322003304 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
340322003305 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
340322003306 Domain of unknown function DUF108; Region: DUF108; pfam01958
340322003307 Protein of unknown function (DUF2872); Region: DUF2872; pfam11071
340322003308 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
340322003309 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
340322003310 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
340322003311 nudix motif; other site
340322003312 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
340322003313 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
340322003314 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
340322003315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322003316 putative substrate translocation pore; other site
340322003317 Transcriptional regulators [Transcription]; Region: MarR; COG1846
340322003318 MarR family; Region: MarR_2; pfam12802
340322003319 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
340322003320 Protein of unknown function, DUF488; Region: DUF488; pfam04343
340322003321 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
340322003322 NADH(P)-binding; Region: NAD_binding_10; pfam13460
340322003323 NAD(P) binding site [chemical binding]; other site
340322003324 putative active site [active]
340322003325 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
340322003326 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
340322003327 Sulfate transporter family; Region: Sulfate_transp; pfam00916
340322003328 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
340322003329 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867
340322003330 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
340322003331 metal ion-dependent adhesion site (MIDAS); other site
340322003332 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
340322003333 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
340322003334 catalytic core [active]
340322003335 conserved hypothetical protein; Region: TIGR03843
340322003336 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
340322003337 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
340322003338 tetramer interface [polypeptide binding]; other site
340322003339 active site
340322003340 Mg2+/Mn2+ binding site [ion binding]; other site
340322003341 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322003342 Walker A/P-loop; other site
340322003343 ATP binding site [chemical binding]; other site
340322003344 ABC transporter; Region: ABC_tran; pfam00005
340322003345 Q-loop/lid; other site
340322003346 ABC transporter signature motif; other site
340322003347 Walker B; other site
340322003348 D-loop; other site
340322003349 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322003350 H-loop/switch region; other site
340322003351 ABC transporter; Region: ABC_tran_2; pfam12848
340322003352 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
340322003353 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
340322003354 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
340322003355 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
340322003356 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
340322003357 PhnA protein; Region: PhnA; pfam03831
340322003358 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
340322003359 putative DNA binding site [nucleotide binding]; other site
340322003360 Transcriptional regulators [Transcription]; Region: MarR; COG1846
340322003361 putative Zn2+ binding site [ion binding]; other site
340322003362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322003363 Major Facilitator Superfamily; Region: MFS_1; pfam07690
340322003364 putative substrate translocation pore; other site
340322003365 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
340322003366 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
340322003367 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
340322003368 catalytic residue [active]
340322003369 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543
340322003370 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
340322003371 dimerization interface [polypeptide binding]; other site
340322003372 active site
340322003373 quinolinate synthetase; Provisional; Region: PRK09375
340322003374 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
340322003375 nudix motif; other site
340322003376 Uncharacterized conserved protein [General function prediction only]; Region: COG4111
340322003377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
340322003378 Protein of unknown function, DUF606; Region: DUF606; pfam04657
340322003379 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
340322003380 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
340322003381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
340322003382 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
340322003383 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
340322003384 dimer interface [polypeptide binding]; other site
340322003385 benzoate transport; Region: 2A0115; TIGR00895
340322003386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322003387 putative substrate translocation pore; other site
340322003388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322003389 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
340322003390 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
340322003391 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721
340322003392 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
340322003393 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
340322003394 Walker A/P-loop; other site
340322003395 ATP binding site [chemical binding]; other site
340322003396 Q-loop/lid; other site
340322003397 ABC transporter signature motif; other site
340322003398 Walker B; other site
340322003399 D-loop; other site
340322003400 H-loop/switch region; other site
340322003401 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
340322003402 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
340322003403 Walker A/P-loop; other site
340322003404 ATP binding site [chemical binding]; other site
340322003405 Q-loop/lid; other site
340322003406 ABC transporter signature motif; other site
340322003407 Walker B; other site
340322003408 D-loop; other site
340322003409 H-loop/switch region; other site
340322003410 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
340322003411 hypothetical protein; Provisional; Region: PRK06547
340322003412 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
340322003413 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
340322003414 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
340322003415 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
340322003416 Predicted integral membrane protein [Function unknown]; Region: COG5522
340322003417 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322003418 Walker A/P-loop; other site
340322003419 ATP binding site [chemical binding]; other site
340322003420 Q-loop/lid; other site
340322003421 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
340322003422 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322003423 ABC transporter signature motif; other site
340322003424 Walker B; other site
340322003425 D-loop; other site
340322003426 H-loop/switch region; other site
340322003427 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322003428 Walker A/P-loop; other site
340322003429 ATP binding site [chemical binding]; other site
340322003430 Q-loop/lid; other site
340322003431 ABC transporter signature motif; other site
340322003432 Walker B; other site
340322003433 D-loop; other site
340322003434 H-loop/switch region; other site
340322003435 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
340322003436 dimer interface [polypeptide binding]; other site
340322003437 catalytic triad [active]
340322003438 peroxidatic and resolving cysteines [active]
340322003439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
340322003440 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
340322003441 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
340322003442 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
340322003443 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424
340322003444 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
340322003445 nudix motif; other site
340322003446 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
340322003447 Trypsin; Region: Trypsin; pfam00089
340322003448 active site
340322003449 substrate binding sites [chemical binding]; other site
340322003450 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
340322003451 ArsC family; Region: ArsC; pfam03960
340322003452 catalytic residues [active]
340322003453 Uncharacterized membrane protein [Function unknown]; Region: COG3949
340322003454 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306
340322003455 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
340322003456 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
340322003457 G1 box; other site
340322003458 GTP/Mg2+ binding site [chemical binding]; other site
340322003459 G2 box; other site
340322003460 Switch I region; other site
340322003461 G3 box; other site
340322003462 Switch II region; other site
340322003463 G4 box; other site
340322003464 G5 box; other site
340322003465 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
340322003466 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710
340322003467 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
340322003468 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
340322003469 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
340322003470 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
340322003471 Ferredoxin [Energy production and conversion]; Region: COG1146
340322003472 4Fe-4S binding domain; Region: Fer4; pfam00037
340322003473 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
340322003474 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
340322003475 pyridoxal 5'-phosphate binding site [chemical binding]; other site
340322003476 homodimer interface [polypeptide binding]; other site
340322003477 catalytic residue [active]
340322003478 Predicted membrane protein [Function unknown]; Region: COG2246
340322003479 GtrA-like protein; Region: GtrA; pfam04138
340322003480 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
340322003481 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
340322003482 active site
340322003483 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
340322003484 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
340322003485 putative trimer interface [polypeptide binding]; other site
340322003486 putative CoA binding site [chemical binding]; other site
340322003487 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
340322003488 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
340322003489 Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism]; Region: DapD; COG2171
340322003490 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
340322003491 putative trimer interface [polypeptide binding]; other site
340322003492 putative CoA binding site [chemical binding]; other site
340322003493 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
340322003494 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
340322003495 metal binding site [ion binding]; metal-binding site
340322003496 putative dimer interface [polypeptide binding]; other site
340322003497 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
340322003498 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219
340322003499 substrate binding pocket [chemical binding]; other site
340322003500 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219
340322003501 inhibitor binding site; inhibition site
340322003502 dimer interface [polypeptide binding]; other site
340322003503 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
340322003504 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
340322003505 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
340322003506 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
340322003507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340322003508 S-adenosylmethionine binding site [chemical binding]; other site
340322003509 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
340322003510 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
340322003511 active site
340322003512 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
340322003513 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
340322003514 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
340322003515 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
340322003516 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
340322003517 ligand binding site; other site
340322003518 oligomer interface; other site
340322003519 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
340322003520 sulfate 1 binding site; other site
340322003521 Predicted O-methyltransferase [General function prediction only]; Region: COG4122
340322003522 Methyltransferase domain; Region: Methyltransf_24; pfam13578
340322003523 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
340322003524 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
340322003525 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
340322003526 DNA binding residues [nucleotide binding]
340322003527 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806
340322003528 sec-independent translocase; Provisional; Region: tatB; PRK00182
340322003529 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
340322003530 Domain of unknown function DUF59; Region: DUF59; pfam01883
340322003531 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
340322003532 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
340322003533 Predicted membrane protein [Function unknown]; Region: COG4420
340322003534 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
340322003535 MgtE intracellular N domain; Region: MgtE_N; smart00924
340322003536 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
340322003537 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
340322003538 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
340322003539 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
340322003540 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
340322003541 TPP-binding site [chemical binding]; other site
340322003542 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
340322003543 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
340322003544 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
340322003545 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322003546 Walker A/P-loop; other site
340322003547 ATP binding site [chemical binding]; other site
340322003548 Q-loop/lid; other site
340322003549 ABC transporter signature motif; other site
340322003550 Walker B; other site
340322003551 D-loop; other site
340322003552 H-loop/switch region; other site
340322003553 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
340322003554 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
340322003555 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322003556 Walker A/P-loop; other site
340322003557 ATP binding site [chemical binding]; other site
340322003558 Q-loop/lid; other site
340322003559 ABC transporter signature motif; other site
340322003560 Walker B; other site
340322003561 D-loop; other site
340322003562 H-loop/switch region; other site
340322003563 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
340322003564 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
340322003565 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
340322003566 shikimate binding site; other site
340322003567 NAD(P) binding site [chemical binding]; other site
340322003568 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
340322003569 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
340322003570 substrate binding pocket [chemical binding]; other site
340322003571 catalytic triad [active]
340322003572 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
340322003573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322003574 putative substrate translocation pore; other site
340322003575 Major Facilitator Superfamily; Region: MFS_1; pfam07690
340322003576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322003577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322003578 Major Facilitator Superfamily; Region: MFS_1; pfam07690
340322003579 putative substrate translocation pore; other site
340322003580 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
340322003581 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
340322003582 THF binding site; other site
340322003583 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
340322003584 substrate binding site [chemical binding]; other site
340322003585 THF binding site; other site
340322003586 zinc-binding site [ion binding]; other site
340322003587 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
340322003588 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
340322003589 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
340322003590 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
340322003591 active site
340322003592 nucleophile elbow; other site
340322003593 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
340322003594 Condensation domain; Region: Condensation; pfam00668
340322003595 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
340322003596 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
340322003597 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322003598 Q-loop/lid; other site
340322003599 ABC transporter signature motif; other site
340322003600 Walker B; other site
340322003601 D-loop; other site
340322003602 H-loop/switch region; other site
340322003603 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
340322003604 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
340322003605 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
340322003606 Walker A/P-loop; other site
340322003607 ATP binding site [chemical binding]; other site
340322003608 Q-loop/lid; other site
340322003609 ABC transporter signature motif; other site
340322003610 Walker B; other site
340322003611 D-loop; other site
340322003612 H-loop/switch region; other site
340322003613 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
340322003614 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
340322003615 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
340322003616 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
340322003617 PLD-like domain; Region: PLDc_2; pfam13091
340322003618 putative homodimer interface [polypeptide binding]; other site
340322003619 putative active site [active]
340322003620 catalytic site [active]
340322003621 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
340322003622 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
340322003623 ATP binding site [chemical binding]; other site
340322003624 putative Mg++ binding site [ion binding]; other site
340322003625 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
340322003626 nucleotide binding region [chemical binding]; other site
340322003627 ATP-binding site [chemical binding]; other site
340322003628 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
340322003629 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
340322003630 active site
340322003631 8-oxo-dGMP binding site [chemical binding]; other site
340322003632 nudix motif; other site
340322003633 metal binding site [ion binding]; metal-binding site
340322003634 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
340322003635 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
340322003636 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268
340322003637 ATP binding site [chemical binding]; other site
340322003638 Mg++ binding site [ion binding]; other site
340322003639 motif III; other site
340322003640 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
340322003641 nucleotide binding region [chemical binding]; other site
340322003642 ATP-binding site [chemical binding]; other site
340322003643 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
340322003644 putative RNA binding site [nucleotide binding]; other site
340322003645 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
340322003646 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
340322003647 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
340322003648 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
340322003649 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
340322003650 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
340322003651 active site
340322003652 dimer interface [polypeptide binding]; other site
340322003653 metal binding site [ion binding]; metal-binding site
340322003654 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
340322003655 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
340322003656 active site
340322003657 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
340322003658 Predicted symporter [General function prediction only]; Region: DhlC; COG4147
340322003659 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
340322003660 Na binding site [ion binding]; other site
340322003661 SNF2 Helicase protein; Region: DUF3670; pfam12419
340322003662 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
340322003663 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
340322003664 putative Mg++ binding site [ion binding]; other site
340322003665 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
340322003666 nucleotide binding region [chemical binding]; other site
340322003667 ATP-binding site [chemical binding]; other site
340322003668 Uncharacterized conserved protein [Function unknown]; Region: COG4279
340322003669 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
340322003670 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
340322003671 active site
340322003672 metal binding site [ion binding]; metal-binding site
340322003673 DNA binding site [nucleotide binding]
340322003674 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
340322003675 AAA domain; Region: AAA_27; pfam13514
340322003676 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
340322003677 Transcriptional regulators [Transcription]; Region: MarR; COG1846
340322003678 MarR family; Region: MarR_2; pfam12802
340322003679 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
340322003680 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
340322003681 ligand binding site [chemical binding]; other site
340322003682 flexible hinge region; other site
340322003683 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
340322003684 non-specific DNA interactions [nucleotide binding]; other site
340322003685 DNA binding site [nucleotide binding]
340322003686 sequence specific DNA binding site [nucleotide binding]; other site
340322003687 putative cAMP binding site [chemical binding]; other site
340322003688 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
340322003689 metal-binding site [ion binding]
340322003690 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
340322003691 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
340322003692 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
340322003693 motif II; other site
340322003694 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
340322003695 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
340322003696 synthetase active site [active]
340322003697 NTP binding site [chemical binding]; other site
340322003698 metal binding site [ion binding]; metal-binding site
340322003699 TAP-like protein; Region: Abhydrolase_4; pfam08386
340322003700 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
340322003701 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
340322003702 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
340322003703 active site
340322003704 HIGH motif; other site
340322003705 KMSK motif region; other site
340322003706 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
340322003707 tRNA binding surface [nucleotide binding]; other site
340322003708 anticodon binding site; other site
340322003709 diaminopimelate decarboxylase; Region: lysA; TIGR01048
340322003710 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
340322003711 active site
340322003712 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
340322003713 substrate binding site [chemical binding]; other site
340322003714 catalytic residues [active]
340322003715 dimer interface [polypeptide binding]; other site
340322003716 homoserine dehydrogenase; Provisional; Region: PRK06349
340322003717 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
340322003718 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
340322003719 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
340322003720 homoserine kinase; Provisional; Region: PRK01212
340322003721 Predicted transcriptional regulator [Transcription]; Region: COG2345
340322003722 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
340322003723 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
340322003724 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
340322003725 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
340322003726 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
340322003727 [4Fe-4S] binding site [ion binding]; other site
340322003728 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
340322003729 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
340322003730 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
340322003731 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
340322003732 molybdopterin cofactor binding site; other site
340322003733 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
340322003734 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
340322003735 MPT binding site; other site
340322003736 trimer interface [polypeptide binding]; other site
340322003737 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
340322003738 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
340322003739 active site
340322003740 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
340322003741 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
340322003742 Domain of unknown function DUF21; Region: DUF21; pfam01595
340322003743 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
340322003744 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
340322003745 Domain of unknown function DUF21; Region: DUF21; pfam01595
340322003746 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
340322003747 Transporter associated domain; Region: CorC_HlyC; pfam03471
340322003748 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
340322003749 GTP binding site; other site
340322003750 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
340322003751 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
340322003752 dimer interface [polypeptide binding]; other site
340322003753 putative functional site; other site
340322003754 putative MPT binding site; other site
340322003755 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
340322003756 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
340322003757 FeS/SAM binding site; other site
340322003758 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
340322003759 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620
340322003760 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
340322003761 dimer interface [polypeptide binding]; other site
340322003762 acyl-activating enzyme (AAE) consensus motif; other site
340322003763 putative active site [active]
340322003764 AMP binding site [chemical binding]; other site
340322003765 putative CoA binding site [chemical binding]; other site
340322003766 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
340322003767 transcription termination factor Rho; Provisional; Region: PRK12608
340322003768 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
340322003769 RNA binding site [nucleotide binding]; other site
340322003770 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
340322003771 multimer interface [polypeptide binding]; other site
340322003772 Walker A motif; other site
340322003773 ATP binding site [chemical binding]; other site
340322003774 Walker B motif; other site
340322003775 peptide chain release factor 1; Validated; Region: prfA; PRK00591
340322003776 This domain is found in peptide chain release factors; Region: PCRF; smart00937
340322003777 RF-1 domain; Region: RF-1; pfam00472
340322003778 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
340322003779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340322003780 S-adenosylmethionine binding site [chemical binding]; other site
340322003781 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
340322003782 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
340322003783 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
340322003784 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
340322003785 Mg++ binding site [ion binding]; other site
340322003786 putative catalytic motif [active]
340322003787 substrate binding site [chemical binding]; other site
340322003788 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
340322003789 F0F1 ATP synthase subunit A; Validated; Region: PRK05815
340322003790 F0F1 ATP synthase subunit C; Validated; Region: PRK07874
340322003791 F0F1 ATP synthase subunit B; Validated; Region: PRK05759
340322003792 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
340322003793 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
340322003794 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
340322003795 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
340322003796 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
340322003797 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
340322003798 beta subunit interaction interface [polypeptide binding]; other site
340322003799 Walker A motif; other site
340322003800 ATP binding site [chemical binding]; other site
340322003801 Walker B motif; other site
340322003802 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
340322003803 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
340322003804 core domain interface [polypeptide binding]; other site
340322003805 delta subunit interface [polypeptide binding]; other site
340322003806 epsilon subunit interface [polypeptide binding]; other site
340322003807 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
340322003808 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
340322003809 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
340322003810 alpha subunit interaction interface [polypeptide binding]; other site
340322003811 Walker A motif; other site
340322003812 ATP binding site [chemical binding]; other site
340322003813 Walker B motif; other site
340322003814 inhibitor binding site; inhibition site
340322003815 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
340322003816 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
340322003817 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
340322003818 gamma subunit interface [polypeptide binding]; other site
340322003819 epsilon subunit interface [polypeptide binding]; other site
340322003820 LBP interface [polypeptide binding]; other site
340322003821 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
340322003822 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637
340322003823 hypothetical protein; Provisional; Region: PRK03298
340322003824 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
340322003825 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
340322003826 dimer interface [polypeptide binding]; other site
340322003827 substrate binding site [chemical binding]; other site
340322003828 metal binding site [ion binding]; metal-binding site
340322003829 Uncharacterized conserved protein [Function unknown]; Region: COG0011
340322003830 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
340322003831 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
340322003832 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
340322003833 alkanesulfonate monooxygenase; Provisional; Region: PRK00719
340322003834 dimer interface [polypeptide binding]; other site
340322003835 active site
340322003836 non-prolyl cis peptide bond; other site
340322003837 insertion regions; other site
340322003838 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
340322003839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322003840 dimer interface [polypeptide binding]; other site
340322003841 conserved gate region; other site
340322003842 putative PBP binding loops; other site
340322003843 ABC-ATPase subunit interface; other site
340322003844 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
340322003845 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
340322003846 Walker A/P-loop; other site
340322003847 ATP binding site [chemical binding]; other site
340322003848 Q-loop/lid; other site
340322003849 ABC transporter signature motif; other site
340322003850 Walker B; other site
340322003851 D-loop; other site
340322003852 H-loop/switch region; other site
340322003853 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
340322003854 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
340322003855 substrate binding pocket [chemical binding]; other site
340322003856 membrane-bound complex binding site; other site
340322003857 hinge residues; other site
340322003858 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136
340322003859 glycogen branching enzyme; Provisional; Region: PRK05402
340322003860 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
340322003861 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
340322003862 active site
340322003863 catalytic site [active]
340322003864 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
340322003865 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
340322003866 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
340322003867 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
340322003868 active site
340322003869 catalytic site [active]
340322003870 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
340322003871 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322003872 Walker A/P-loop; other site
340322003873 ATP binding site [chemical binding]; other site
340322003874 Q-loop/lid; other site
340322003875 ABC transporter signature motif; other site
340322003876 Walker B; other site
340322003877 D-loop; other site
340322003878 H-loop/switch region; other site
340322003879 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
340322003880 Ligand binding site [chemical binding]; other site
340322003881 Electron transfer flavoprotein domain; Region: ETF; pfam01012
340322003882 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
340322003883 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
340322003884 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
340322003885 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
340322003886 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
340322003887 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
340322003888 catalytic residue [active]
340322003889 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
340322003890 HipA N-terminal domain; Region: couple_hipA; TIGR03071
340322003891 HipA-like N-terminal domain; Region: HipA_N; pfam07805
340322003892 HipA-like C-terminal domain; Region: HipA_C; pfam07804
340322003893 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340322003894 salt bridge; other site
340322003895 non-specific DNA binding site [nucleotide binding]; other site
340322003896 sequence-specific DNA binding site [nucleotide binding]; other site
340322003897 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
340322003898 Coenzyme A binding pocket [chemical binding]; other site
340322003899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340322003900 S-adenosylmethionine binding site [chemical binding]; other site
340322003901 AAA ATPase domain; Region: AAA_16; pfam13191
340322003902 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
340322003903 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
340322003904 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
340322003905 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322003906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322003907 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
340322003908 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
340322003909 active site
340322003910 catalytic site [active]
340322003911 substrate binding site [chemical binding]; other site
340322003912 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
340322003913 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
340322003914 nucleotide binding pocket [chemical binding]; other site
340322003915 K-X-D-G motif; other site
340322003916 catalytic site [active]
340322003917 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
340322003918 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
340322003919 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
340322003920 Dimer interface [polypeptide binding]; other site
340322003921 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
340322003922 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
340322003923 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
340322003924 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
340322003925 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
340322003926 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
340322003927 FAD binding pocket [chemical binding]; other site
340322003928 FAD binding motif [chemical binding]; other site
340322003929 phosphate binding motif [ion binding]; other site
340322003930 NAD binding pocket [chemical binding]; other site
340322003931 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
340322003932 phosphofructokinase; Region: PFK_mixed; TIGR02483
340322003933 active site
340322003934 ADP/pyrophosphate binding site [chemical binding]; other site
340322003935 dimerization interface [polypeptide binding]; other site
340322003936 allosteric effector site; other site
340322003937 fructose-1,6-bisphosphate binding site; other site
340322003938 Transcriptional regulators [Transcription]; Region: PurR; COG1609
340322003939 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
340322003940 DNA binding site [nucleotide binding]
340322003941 domain linker motif; other site
340322003942 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299
340322003943 dimerization interface [polypeptide binding]; other site
340322003944 putative ligand binding site [chemical binding]; other site
340322003945 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
340322003946 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
340322003947 Walker A/P-loop; other site
340322003948 ATP binding site [chemical binding]; other site
340322003949 Q-loop/lid; other site
340322003950 ABC transporter signature motif; other site
340322003951 Walker B; other site
340322003952 D-loop; other site
340322003953 H-loop/switch region; other site
340322003954 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
340322003955 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
340322003956 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
340322003957 TM-ABC transporter signature motif; other site
340322003958 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
340322003959 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
340322003960 ligand binding site [chemical binding]; other site
340322003961 dimerization interface [polypeptide binding]; other site
340322003962 D-ribose pyranase; Provisional; Region: PRK11797
340322003963 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
340322003964 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
340322003965 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
340322003966 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
340322003967 siderophore binding site; other site
340322003968 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
340322003969 Sodium Bile acid symporter family; Region: SBF; pfam01758
340322003970 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
340322003971 GatB/GatE catalytic domain; Region: GatB_N; pfam02934
340322003972 GatB domain; Region: GatB_Yqey; pfam02637
340322003973 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
340322003974 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
340322003975 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
340322003976 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
340322003977 active site
340322003978 catalytic tetrad [active]
340322003979 L-lysine exporter; Region: 2a75; TIGR00948
340322003980 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
340322003981 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
340322003982 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
340322003983 dimerization interface [polypeptide binding]; other site
340322003984 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
340322003985 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
340322003986 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
340322003987 putative dimer interface [polypeptide binding]; other site
340322003988 N-terminal domain interface [polypeptide binding]; other site
340322003989 putative substrate binding pocket (H-site) [chemical binding]; other site
340322003990 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
340322003991 Predicted membrane protein [Function unknown]; Region: COG2259
340322003992 dihydroxy-acid dehydratase; Provisional; Region: PRK12448
340322003993 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
340322003994 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
340322003995 Mechanosensitive ion channel; Region: MS_channel; pfam00924
340322003996 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
340322003997 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
340322003998 PYR/PP interface [polypeptide binding]; other site
340322003999 dimer interface [polypeptide binding]; other site
340322004000 TPP binding site [chemical binding]; other site
340322004001 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
340322004002 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
340322004003 TPP-binding site [chemical binding]; other site
340322004004 dimer interface [polypeptide binding]; other site
340322004005 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
340322004006 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
340322004007 putative valine binding site [chemical binding]; other site
340322004008 dimer interface [polypeptide binding]; other site
340322004009 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
340322004010 ketol-acid reductoisomerase; Provisional; Region: PRK05479
340322004011 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
340322004012 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
340322004013 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322004014 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
340322004015 ABC transporter signature motif; other site
340322004016 Walker B; other site
340322004017 D-loop; other site
340322004018 H-loop/switch region; other site
340322004019 Protein of unknown function (DUF1602); Region: DUF1602; pfam07673
340322004020 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
340322004021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322004022 Walker A/P-loop; other site
340322004023 ATP binding site [chemical binding]; other site
340322004024 Q-loop/lid; other site
340322004025 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
340322004026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322004027 dimer interface [polypeptide binding]; other site
340322004028 conserved gate region; other site
340322004029 putative PBP binding loops; other site
340322004030 ABC-ATPase subunit interface; other site
340322004031 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
340322004032 NMT1-like family; Region: NMT1_2; pfam13379
340322004033 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
340322004034 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
340322004035 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
340322004036 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
340322004037 Uncharacterized conserved protein [Function unknown]; Region: COG1479
340322004038 Protein of unknown function DUF262; Region: DUF262; pfam03235
340322004039 Uncharacterized conserved protein [Function unknown]; Region: COG3472
340322004040 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
340322004041 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
340322004042 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
340322004043 ligand binding site [chemical binding]; other site
340322004044 NAD binding site [chemical binding]; other site
340322004045 dimerization interface [polypeptide binding]; other site
340322004046 catalytic site [active]
340322004047 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
340322004048 putative L-serine binding site [chemical binding]; other site
340322004049 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
340322004050 tartrate dehydrogenase; Region: TTC; TIGR02089
340322004051 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
340322004052 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
340322004053 substrate binding pocket [chemical binding]; other site
340322004054 membrane-bound complex binding site; other site
340322004055 hinge residues; other site
340322004056 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
340322004057 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
340322004058 ligand binding site [chemical binding]; other site
340322004059 flexible hinge region; other site
340322004060 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
340322004061 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
340322004062 metal binding triad; other site
340322004063 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
340322004064 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
340322004065 active site
340322004066 catalytic site [active]
340322004067 substrate binding site [chemical binding]; other site
340322004068 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
340322004069 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
340322004070 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
340322004071 Methyltransferase domain; Region: Methyltransf_23; pfam13489
340322004072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340322004073 S-adenosylmethionine binding site [chemical binding]; other site
340322004074 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
340322004075 chorismate binding enzyme; Region: Chorismate_bind; pfam00425
340322004076 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
340322004077 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
340322004078 active site
340322004079 HIGH motif; other site
340322004080 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
340322004081 active site
340322004082 KMSKS motif; other site
340322004083 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340322004084 salt bridge; other site
340322004085 non-specific DNA binding site [nucleotide binding]; other site
340322004086 sequence-specific DNA binding site [nucleotide binding]; other site
340322004087 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
340322004088 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822
340322004089 putative hydrophobic ligand binding site [chemical binding]; other site
340322004090 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
340322004091 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
340322004092 WHG domain; Region: WHG; pfam13305
340322004093 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
340322004094 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
340322004095 ThiC-associated domain; Region: ThiC-associated; pfam13667
340322004096 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
340322004097 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
340322004098 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
340322004099 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
340322004100 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
340322004101 active site residue [active]
340322004102 Sulfite exporter TauE/SafE; Region: TauE; pfam01925
340322004103 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
340322004104 HD domain; Region: HD_4; pfam13328
340322004105 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
340322004106 Transcriptional regulator [Transcription]; Region: IclR; COG1414
340322004107 Bacterial transcriptional regulator; Region: IclR; pfam01614
340322004108 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
340322004109 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
340322004110 substrate binding site [chemical binding]; other site
340322004111 ligand binding site [chemical binding]; other site
340322004112 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
340322004113 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
340322004114 substrate binding site [chemical binding]; other site
340322004115 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
340322004116 active site
340322004117 Ap6A binding site [chemical binding]; other site
340322004118 nudix motif; other site
340322004119 metal binding site [ion binding]; metal-binding site
340322004120 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
340322004121 catalytic core [active]
340322004122 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
340322004123 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
340322004124 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
340322004125 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
340322004126 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
340322004127 ATP-grasp domain; Region: ATP-grasp_4; cl17255
340322004128 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
340322004129 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
340322004130 thiamine monophosphate kinase; Provisional; Region: PRK05731
340322004131 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
340322004132 ATP binding site [chemical binding]; other site
340322004133 dimerization interface [polypeptide binding]; other site
340322004134 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
340322004135 ligand binding site [chemical binding]; other site
340322004136 active site
340322004137 UGI interface [polypeptide binding]; other site
340322004138 catalytic site [active]
340322004139 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
340322004140 DAK2 domain; Region: Dak2; pfam02734
340322004141 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200
340322004142 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
340322004143 generic binding surface II; other site
340322004144 ssDNA binding site; other site
340322004145 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
340322004146 ATP binding site [chemical binding]; other site
340322004147 putative Mg++ binding site [ion binding]; other site
340322004148 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
340322004149 nucleotide binding region [chemical binding]; other site
340322004150 ATP-binding site [chemical binding]; other site
340322004151 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
340322004152 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
340322004153 carboxyltransferase (CT) interaction site; other site
340322004154 biotinylation site [posttranslational modification]; other site
340322004155 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
340322004156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340322004157 S-adenosylmethionine binding site [chemical binding]; other site
340322004158 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
340322004159 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
340322004160 active site
340322004161 (T/H)XGH motif; other site
340322004162 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
340322004163 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
340322004164 Walker A/P-loop; other site
340322004165 ATP binding site [chemical binding]; other site
340322004166 Q-loop/lid; other site
340322004167 ABC transporter signature motif; other site
340322004168 Walker B; other site
340322004169 D-loop; other site
340322004170 H-loop/switch region; other site
340322004171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322004172 dimer interface [polypeptide binding]; other site
340322004173 conserved gate region; other site
340322004174 putative PBP binding loops; other site
340322004175 ABC-ATPase subunit interface; other site
340322004176 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
340322004177 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
340322004178 substrate binding pocket [chemical binding]; other site
340322004179 membrane-bound complex binding site; other site
340322004180 hinge residues; other site
340322004181 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
340322004182 Predicted membrane protein [Function unknown]; Region: COG2035
340322004183 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
340322004184 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
340322004185 active site
340322004186 DNA binding site [nucleotide binding]
340322004187 Int/Topo IB signature motif; other site
340322004188 putative transposase OrfB; Reviewed; Region: PHA02517
340322004189 HTH-like domain; Region: HTH_21; pfam13276
340322004190 Integrase core domain; Region: rve; pfam00665
340322004191 Integrase core domain; Region: rve_3; pfam13683
340322004192 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
340322004193 Transposase; Region: HTH_Tnp_1; pfam01527
340322004194 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
340322004195 Uncharacterized conserved small protein [Function unknown]; Region: COG5428
340322004196 putative assembly protein; Provisional; Region: PRK10833
340322004197 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
340322004198 DNA polymerase I; Provisional; Region: PRK05755
340322004199 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
340322004200 active site
340322004201 metal binding site 1 [ion binding]; metal-binding site
340322004202 putative 5' ssDNA interaction site; other site
340322004203 metal binding site 3; metal-binding site
340322004204 metal binding site 2 [ion binding]; metal-binding site
340322004205 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
340322004206 putative DNA binding site [nucleotide binding]; other site
340322004207 putative metal binding site [ion binding]; other site
340322004208 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
340322004209 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
340322004210 active site
340322004211 DNA binding site [nucleotide binding]
340322004212 catalytic site [active]
340322004213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322004214 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340322004215 salt bridge; other site
340322004216 non-specific DNA binding site [nucleotide binding]; other site
340322004217 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
340322004218 sequence-specific DNA binding site [nucleotide binding]; other site
340322004219 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
340322004220 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
340322004221 active site
340322004222 catalytic tetrad [active]
340322004223 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
340322004224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340322004225 S-adenosylmethionine binding site [chemical binding]; other site
340322004226 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
340322004227 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
340322004228 RNA binding site [nucleotide binding]; other site
340322004229 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
340322004230 RNA binding site [nucleotide binding]; other site
340322004231 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
340322004232 RNA binding site [nucleotide binding]; other site
340322004233 S1 RNA binding domain; Region: S1; pfam00575
340322004234 RNA binding site [nucleotide binding]; other site
340322004235 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
340322004236 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
340322004237 active site turn [active]
340322004238 phosphorylation site [posttranslational modification]
340322004239 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
340322004240 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
340322004241 HPr interaction site; other site
340322004242 glycerol kinase (GK) interaction site [polypeptide binding]; other site
340322004243 active site
340322004244 phosphorylation site [posttranslational modification]
340322004245 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
340322004246 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
340322004247 CoA-binding site [chemical binding]; other site
340322004248 ATP-binding [chemical binding]; other site
340322004249 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
340322004250 active site
340322004251 tetramer interface [polypeptide binding]; other site
340322004252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322004253 putative substrate translocation pore; other site
340322004254 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
340322004255 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
340322004256 substrate binding site [chemical binding]; other site
340322004257 dimer interface [polypeptide binding]; other site
340322004258 ATP binding site [chemical binding]; other site
340322004259 Transcriptional regulators [Transcription]; Region: PurR; COG1609
340322004260 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
340322004261 DNA binding site [nucleotide binding]
340322004262 domain linker motif; other site
340322004263 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299
340322004264 dimerization interface [polypeptide binding]; other site
340322004265 putative ligand binding site [chemical binding]; other site
340322004266 excinuclease ABC subunit B; Provisional; Region: PRK05298
340322004267 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
340322004268 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
340322004269 nucleotide binding region [chemical binding]; other site
340322004270 ATP-binding site [chemical binding]; other site
340322004271 Ultra-violet resistance protein B; Region: UvrB; pfam12344
340322004272 UvrB/uvrC motif; Region: UVR; pfam02151
340322004273 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
340322004274 Ligand Binding Site [chemical binding]; other site
340322004275 Predicted transcriptional regulators [Transcription]; Region: COG1733
340322004276 HxlR-like helix-turn-helix; Region: HxlR; pfam01638
340322004277 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
340322004278 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
340322004279 NADP binding site [chemical binding]; other site
340322004280 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
340322004281 Part of AAA domain; Region: AAA_19; pfam13245
340322004282 Family description; Region: UvrD_C_2; pfam13538
340322004283 Predicted membrane protein [Function unknown]; Region: COG2259
340322004284 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
340322004285 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
340322004286 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
340322004287 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
340322004288 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
340322004289 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
340322004290 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
340322004291 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
340322004292 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
340322004293 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
340322004294 Ribosomal protein L20; Region: Ribosomal_L20; cd07026
340322004295 23S rRNA binding site [nucleotide binding]; other site
340322004296 L21 binding site [polypeptide binding]; other site
340322004297 L13 binding site [polypeptide binding]; other site
340322004298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322004299 dimer interface [polypeptide binding]; other site
340322004300 conserved gate region; other site
340322004301 putative PBP binding loops; other site
340322004302 ABC-ATPase subunit interface; other site
340322004303 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
340322004304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322004305 dimer interface [polypeptide binding]; other site
340322004306 conserved gate region; other site
340322004307 putative PBP binding loops; other site
340322004308 ABC-ATPase subunit interface; other site
340322004309 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
340322004310 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
340322004311 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
340322004312 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
340322004313 Walker A/P-loop; other site
340322004314 ATP binding site [chemical binding]; other site
340322004315 Q-loop/lid; other site
340322004316 ABC transporter signature motif; other site
340322004317 Walker B; other site
340322004318 D-loop; other site
340322004319 H-loop/switch region; other site
340322004320 TOBE domain; Region: TOBE_2; pfam08402
340322004321 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
340322004322 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
340322004323 active site
340322004324 catalytic site [active]
340322004325 metal binding site [ion binding]; metal-binding site
340322004326 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
340322004327 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
340322004328 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
340322004329 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
340322004330 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
340322004331 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
340322004332 dimer interface [polypeptide binding]; other site
340322004333 motif 1; other site
340322004334 active site
340322004335 motif 2; other site
340322004336 motif 3; other site
340322004337 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
340322004338 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
340322004339 putative tRNA-binding site [nucleotide binding]; other site
340322004340 B3/4 domain; Region: B3_4; pfam03483
340322004341 tRNA synthetase B5 domain; Region: B5; smart00874
340322004342 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769
340322004343 dimer interface [polypeptide binding]; other site
340322004344 motif 1; other site
340322004345 motif 3; other site
340322004346 motif 2; other site
340322004347 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
340322004348 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
340322004349 active site
340322004350 catalytic triad [active]
340322004351 oxyanion hole [active]
340322004352 Predicted acyltransferases [Lipid metabolism]; Region: COG1835
340322004353 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
340322004354 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
340322004355 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
340322004356 heterotetramer interface [polypeptide binding]; other site
340322004357 active site pocket [active]
340322004358 cleavage site
340322004359 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
340322004360 feedback inhibition sensing region; other site
340322004361 homohexameric interface [polypeptide binding]; other site
340322004362 nucleotide binding site [chemical binding]; other site
340322004363 N-acetyl-L-glutamate binding site [chemical binding]; other site
340322004364 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
340322004365 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
340322004366 inhibitor-cofactor binding pocket; inhibition site
340322004367 pyridoxal 5'-phosphate binding site [chemical binding]; other site
340322004368 catalytic residue [active]
340322004369 ornithine carbamoyltransferase; Provisional; Region: PRK00779
340322004370 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
340322004371 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
340322004372 arginine repressor; Provisional; Region: PRK03341
340322004373 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
340322004374 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
340322004375 argininosuccinate synthase; Provisional; Region: PRK13820
340322004376 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999
340322004377 ANP binding site [chemical binding]; other site
340322004378 Substrate Binding Site II [chemical binding]; other site
340322004379 Substrate Binding Site I [chemical binding]; other site
340322004380 argininosuccinate lyase; Provisional; Region: PRK00855
340322004381 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
340322004382 active sites [active]
340322004383 tetramer interface [polypeptide binding]; other site
340322004384 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
340322004385 metal ion-dependent adhesion site (MIDAS); other site
340322004386 Uncharacterized conserved protein [Function unknown]; Region: COG2835
340322004387 tyrosyl-tRNA synthetase; Validated; Region: PRK05912
340322004388 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
340322004389 active site
340322004390 HIGH motif; other site
340322004391 dimer interface [polypeptide binding]; other site
340322004392 KMSKS motif; other site
340322004393 S4 RNA-binding domain; Region: S4; smart00363
340322004394 RNA binding surface [nucleotide binding]; other site
340322004395 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
340322004396 Ligand Binding Site [chemical binding]; other site
340322004397 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
340322004398 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
340322004399 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
340322004400 active site
340322004401 motif I; other site
340322004402 motif II; other site
340322004403 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
340322004404 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
340322004405 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
340322004406 RNA binding surface [nucleotide binding]; other site
340322004407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340322004408 S-adenosylmethionine binding site [chemical binding]; other site
340322004409 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
340322004410 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
340322004411 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
340322004412 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
340322004413 Walker A/P-loop; other site
340322004414 ATP binding site [chemical binding]; other site
340322004415 Q-loop/lid; other site
340322004416 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
340322004417 ABC transporter signature motif; other site
340322004418 Walker B; other site
340322004419 D-loop; other site
340322004420 H-loop/switch region; other site
340322004421 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
340322004422 Thiamine pyrophosphokinase; Region: TPK; cl08415
340322004423 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
340322004424 CTP synthetase; Validated; Region: pyrG; PRK05380
340322004425 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
340322004426 Catalytic site [active]
340322004427 active site
340322004428 UTP binding site [chemical binding]; other site
340322004429 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
340322004430 active site
340322004431 putative oxyanion hole; other site
340322004432 catalytic triad [active]
340322004433 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
340322004434 dimer interface [polypeptide binding]; other site
340322004435 ADP-ribose binding site [chemical binding]; other site
340322004436 active site
340322004437 nudix motif; other site
340322004438 metal binding site [ion binding]; metal-binding site
340322004439 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
340322004440 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
340322004441 active site
340322004442 Int/Topo IB signature motif; other site
340322004443 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
340322004444 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322004445 Walker A/P-loop; other site
340322004446 ATP binding site [chemical binding]; other site
340322004447 Q-loop/lid; other site
340322004448 ABC transporter signature motif; other site
340322004449 Walker B; other site
340322004450 D-loop; other site
340322004451 H-loop/switch region; other site
340322004452 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
340322004453 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
340322004454 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
340322004455 P-loop; other site
340322004456 Magnesium ion binding site [ion binding]; other site
340322004457 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
340322004458 Magnesium ion binding site [ion binding]; other site
340322004459 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354
340322004460 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
340322004461 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
340322004462 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
340322004463 active site residue [active]
340322004464 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
340322004465 active site residue [active]
340322004466 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
340322004467 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
340322004468 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
340322004469 RNA binding surface [nucleotide binding]; other site
340322004470 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
340322004471 active site
340322004472 cytidylate kinase; Provisional; Region: cmk; PRK00023
340322004473 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
340322004474 CMP-binding site; other site
340322004475 The sites determining sugar specificity; other site
340322004476 GTP-binding protein Der; Reviewed; Region: PRK03003
340322004477 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
340322004478 G1 box; other site
340322004479 GTP/Mg2+ binding site [chemical binding]; other site
340322004480 Switch I region; other site
340322004481 G2 box; other site
340322004482 Switch II region; other site
340322004483 G3 box; other site
340322004484 G4 box; other site
340322004485 G5 box; other site
340322004486 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
340322004487 G1 box; other site
340322004488 GTP/Mg2+ binding site [chemical binding]; other site
340322004489 Switch I region; other site
340322004490 G2 box; other site
340322004491 G3 box; other site
340322004492 Switch II region; other site
340322004493 G4 box; other site
340322004494 G5 box; other site
340322004495 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
340322004496 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
340322004497 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978
340322004498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340322004499 S-adenosylmethionine binding site [chemical binding]; other site
340322004500 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
340322004501 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
340322004502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322004503 Walker B; other site
340322004504 D-loop; other site
340322004505 H-loop/switch region; other site
340322004506 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
340322004507 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
340322004508 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322004509 Walker A/P-loop; other site
340322004510 ATP binding site [chemical binding]; other site
340322004511 Q-loop/lid; other site
340322004512 ABC transporter signature motif; other site
340322004513 Walker B; other site
340322004514 D-loop; other site
340322004515 H-loop/switch region; other site
340322004516 zinc transporter ZupT; Provisional; Region: PRK04201
340322004517 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
340322004518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012
340322004519 SEC-C motif; Region: SEC-C; pfam02810
340322004520 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
340322004521 OsmC-like protein; Region: OsmC; cl00767
340322004522 preprotein translocase subunit SecA; Reviewed; Region: PRK12326
340322004523 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
340322004524 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
340322004525 nucleotide binding region [chemical binding]; other site
340322004526 ATP-binding site [chemical binding]; other site
340322004527 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
340322004528 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
340322004529 phosphopeptide binding site; other site
340322004530 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
340322004531 MerR HTH family regulatory protein; Region: MerR_1; pfam13411
340322004532 DNA binding residues [nucleotide binding]
340322004533 Uncharacterized conserved protein [Function unknown]; Region: COG1259
340322004534 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
340322004535 MerR HTH family regulatory protein; Region: MerR_1; pfam13411
340322004536 DNA binding residues [nucleotide binding]
340322004537 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
340322004538 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
340322004539 Domain of unknown function DUF21; Region: DUF21; pfam01595
340322004540 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
340322004541 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
340322004542 Domain of unknown function DUF21; Region: DUF21; pfam01595
340322004543 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
340322004544 Transporter associated domain; Region: CorC_HlyC; smart01091
340322004545 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
340322004546 DEAD-like helicases superfamily; Region: DEXDc; smart00487
340322004547 ATP binding site [chemical binding]; other site
340322004548 putative Mg++ binding site [ion binding]; other site
340322004549 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
340322004550 nucleotide binding region [chemical binding]; other site
340322004551 ATP-binding site [chemical binding]; other site
340322004552 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
340322004553 FAD binding pocket [chemical binding]; other site
340322004554 FAD binding motif [chemical binding]; other site
340322004555 phosphate binding motif [ion binding]; other site
340322004556 Siderophore-interacting protein; Region: SIP; pfam04954
340322004557 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
340322004558 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
340322004559 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
340322004560 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
340322004561 CoenzymeA binding site [chemical binding]; other site
340322004562 subunit interaction site [polypeptide binding]; other site
340322004563 PHB binding site; other site
340322004564 Methyltransferase domain; Region: Methyltransf_31; pfam13847
340322004565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340322004566 S-adenosylmethionine binding site [chemical binding]; other site
340322004567 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
340322004568 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
340322004569 Walker A/P-loop; other site
340322004570 ATP binding site [chemical binding]; other site
340322004571 Q-loop/lid; other site
340322004572 ABC transporter signature motif; other site
340322004573 Walker B; other site
340322004574 D-loop; other site
340322004575 H-loop/switch region; other site
340322004576 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
340322004577 ABC-2 type transporter; Region: ABC2_membrane; cl17235
340322004578 Transcriptional regulators [Transcription]; Region: RpiR; COG1737
340322004579 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
340322004580 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
340322004581 putative active site [active]
340322004582 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
340322004583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322004584 dimer interface [polypeptide binding]; other site
340322004585 conserved gate region; other site
340322004586 ABC-ATPase subunit interface; other site
340322004587 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
340322004588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322004589 dimer interface [polypeptide binding]; other site
340322004590 conserved gate region; other site
340322004591 ABC-ATPase subunit interface; other site
340322004592 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
340322004593 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
340322004594 Walker A/P-loop; other site
340322004595 ATP binding site [chemical binding]; other site
340322004596 Q-loop/lid; other site
340322004597 ABC transporter signature motif; other site
340322004598 Walker B; other site
340322004599 D-loop; other site
340322004600 H-loop/switch region; other site
340322004601 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
340322004602 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
340322004603 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
340322004604 motif I; other site
340322004605 active site
340322004606 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
340322004607 motif II; other site
340322004608 multifunctional thiamine-phosphate pyrophosphorylase/synthase/phosphomethylpyrimidine kinase; Provisional; Region: PRK09517
340322004609 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
340322004610 thiamine phosphate binding site [chemical binding]; other site
340322004611 active site
340322004612 pyrophosphate binding site [ion binding]; other site
340322004613 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
340322004614 dimer interface [polypeptide binding]; other site
340322004615 substrate binding site [chemical binding]; other site
340322004616 ATP binding site [chemical binding]; other site
340322004617 Putative transcription activator [Transcription]; Region: TenA; COG0819
340322004618 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
340322004619 substrate binding site [chemical binding]; other site
340322004620 multimerization interface [polypeptide binding]; other site
340322004621 ATP binding site [chemical binding]; other site
340322004622 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
340322004623 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
340322004624 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
340322004625 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
340322004626 metabolite-proton symporter; Region: 2A0106; TIGR00883
340322004627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322004628 putative substrate translocation pore; other site
340322004629 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
340322004630 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
340322004631 active site
340322004632 Predicted membrane protein [Function unknown]; Region: COG1971
340322004633 Domain of unknown function DUF; Region: DUF204; pfam02659
340322004634 Domain of unknown function DUF; Region: DUF204; pfam02659
340322004635 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
340322004636 Sodium Bile acid symporter family; Region: SBF; cl17470
340322004637 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
340322004638 A new structural DNA glycosylase; Region: AlkD_like; cd06561
340322004639 active site
340322004640 high affinity sulphate transporter 1; Region: sulP; TIGR00815
340322004641 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
340322004642 Sulfate transporter family; Region: Sulfate_transp; pfam00916
340322004643 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
340322004644 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
340322004645 Uncharacterized conserved protein [Function unknown]; Region: COG2353
340322004646 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
340322004647 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
340322004648 Ligand binding site; other site
340322004649 Putative Catalytic site; other site
340322004650 DXD motif; other site
340322004651 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
340322004652 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
340322004653 putative active site [active]
340322004654 catalytic triad [active]
340322004655 putative dimer interface [polypeptide binding]; other site
340322004656 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
340322004657 Secretory lipase; Region: LIP; pfam03583
340322004658 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
340322004659 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
340322004660 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
340322004661 active site
340322004662 putative homodimer interface [polypeptide binding]; other site
340322004663 SAM binding site [chemical binding]; other site
340322004664 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
340322004665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
340322004666 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
340322004667 classical (c) SDRs; Region: SDR_c; cd05233
340322004668 NAD(P) binding site [chemical binding]; other site
340322004669 active site
340322004670 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
340322004671 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
340322004672 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
340322004673 active site
340322004674 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
340322004675 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
340322004676 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
340322004677 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
340322004678 ATP binding site [chemical binding]; other site
340322004679 putative Mg++ binding site [ion binding]; other site
340322004680 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
340322004681 nucleotide binding region [chemical binding]; other site
340322004682 ATP-binding site [chemical binding]; other site
340322004683 DSHCT (NUC185) domain; Region: DSHCT; pfam08148
340322004684 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
340322004685 Predicted transcriptional regulator [Transcription]; Region: COG2378
340322004686 WYL domain; Region: WYL; pfam13280
340322004687 Predicted transcriptional regulator [Transcription]; Region: COG2378
340322004688 WYL domain; Region: WYL; pfam13280
340322004689 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
340322004690 Pup-like protein; Region: Pup; pfam05639
340322004691 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688
340322004692 proteasome ATPase; Region: pup_AAA; TIGR03689
340322004693 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340322004694 Walker A motif; other site
340322004695 ATP binding site [chemical binding]; other site
340322004696 Walker B motif; other site
340322004697 arginine finger; other site
340322004698 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
340322004699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340322004700 S-adenosylmethionine binding site [chemical binding]; other site
340322004701 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
340322004702 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
340322004703 active site
340322004704 metal binding site [ion binding]; metal-binding site
340322004705 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
340322004706 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
340322004707 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340322004708 non-specific DNA binding site [nucleotide binding]; other site
340322004709 salt bridge; other site
340322004710 sequence-specific DNA binding site [nucleotide binding]; other site
340322004711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322004712 Major Facilitator Superfamily; Region: MFS_1; pfam07690
340322004713 putative substrate translocation pore; other site
340322004714 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
340322004715 Aspartase; Region: Aspartase; cd01357
340322004716 active sites [active]
340322004717 tetramer interface [polypeptide binding]; other site
340322004718 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
340322004719 ATP phosphoribosyltransferase; Region: hisG; TIGR00070
340322004720 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
340322004721 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
340322004722 homodimer interface [polypeptide binding]; other site
340322004723 putative metal binding site [ion binding]; other site
340322004724 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
340322004725 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
340322004726 motif II; other site
340322004727 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
340322004728 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
340322004729 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219
340322004730 substrate binding pocket [chemical binding]; other site
340322004731 dimer interface [polypeptide binding]; other site
340322004732 inhibitor binding site; inhibition site
340322004733 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
340322004734 B12 binding site [chemical binding]; other site
340322004735 cobalt ligand [ion binding]; other site
340322004736 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
340322004737 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
340322004738 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
340322004739 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
340322004740 arsenical-resistance protein; Region: acr3; TIGR00832
340322004741 Low molecular weight phosphatase family; Region: LMWPc; cl00105
340322004742 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
340322004743 active site
340322004744 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
340322004745 Low molecular weight phosphatase family; Region: LMWPc; cl00105
340322004746 active site
340322004747 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447
340322004748 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
340322004749 active site
340322004750 HIGH motif; other site
340322004751 nucleotide binding site [chemical binding]; other site
340322004752 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
340322004753 active site
340322004754 KMSKS motif; other site
340322004755 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
340322004756 tRNA binding surface [nucleotide binding]; other site
340322004757 anticodon binding site; other site
340322004758 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
340322004759 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
340322004760 active site
340322004761 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
340322004762 catalytic tetrad [active]
340322004763 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
340322004764 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
340322004765 quinone interaction residues [chemical binding]; other site
340322004766 active site
340322004767 catalytic residues [active]
340322004768 FMN binding site [chemical binding]; other site
340322004769 substrate binding site [chemical binding]; other site
340322004770 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
340322004771 substrate binding site [chemical binding]; other site
340322004772 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
340322004773 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322004774 Walker A/P-loop; other site
340322004775 ATP binding site [chemical binding]; other site
340322004776 Q-loop/lid; other site
340322004777 ABC transporter signature motif; other site
340322004778 Walker B; other site
340322004779 D-loop; other site
340322004780 H-loop/switch region; other site
340322004781 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
340322004782 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
340322004783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322004784 Q-loop/lid; other site
340322004785 ABC transporter signature motif; other site
340322004786 Walker B; other site
340322004787 D-loop; other site
340322004788 H-loop/switch region; other site
340322004789 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
340322004790 Acetyltransferases [General function prediction only]; Region: RimI; COG0456
340322004791 Coenzyme A binding pocket [chemical binding]; other site
340322004792 membrane ATPase/protein kinase; Provisional; Region: PRK09435
340322004793 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
340322004794 Walker A; other site
340322004795 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
340322004796 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
340322004797 active site
340322004798 substrate binding site [chemical binding]; other site
340322004799 coenzyme B12 binding site [chemical binding]; other site
340322004800 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
340322004801 B12 binding site [chemical binding]; other site
340322004802 cobalt ligand [ion binding]; other site
340322004803 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
340322004804 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
340322004805 heterodimer interface [polypeptide binding]; other site
340322004806 substrate interaction site [chemical binding]; other site
340322004807 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185
340322004808 Uncharacterized conserved protein [Function unknown]; Region: COG0398
340322004809 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
340322004810 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
340322004811 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
340322004812 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
340322004813 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
340322004814 ferrochelatase; Reviewed; Region: hemH; PRK00035
340322004815 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
340322004816 C-terminal domain interface [polypeptide binding]; other site
340322004817 active site
340322004818 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
340322004819 active site
340322004820 N-terminal domain interface [polypeptide binding]; other site
340322004821 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
340322004822 NlpC/P60 family; Region: NLPC_P60; pfam00877
340322004823 aconitate hydratase; Validated; Region: PRK09277
340322004824 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
340322004825 substrate binding site [chemical binding]; other site
340322004826 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
340322004827 ligand binding site [chemical binding]; other site
340322004828 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
340322004829 substrate binding site [chemical binding]; other site
340322004830 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
340322004831 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
340322004832 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
340322004833 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
340322004834 catalytic triad [active]
340322004835 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
340322004836 NADH(P)-binding; Region: NAD_binding_10; pfam13460
340322004837 NAD(P) binding site [chemical binding]; other site
340322004838 active site
340322004839 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
340322004840 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
340322004841 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
340322004842 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
340322004843 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
340322004844 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
340322004845 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
340322004846 motif II; other site
340322004847 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
340322004848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762
340322004849 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
340322004850 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
340322004851 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322004852 Walker A/P-loop; other site
340322004853 ATP binding site [chemical binding]; other site
340322004854 Q-loop/lid; other site
340322004855 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
340322004856 ABC transporter signature motif; other site
340322004857 Walker B; other site
340322004858 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
340322004859 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
340322004860 catalytic site [active]
340322004861 BNR repeat-like domain; Region: BNR_2; pfam13088
340322004862 Asp-box motif; other site
340322004863 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
340322004864 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
340322004865 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
340322004866 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
340322004867 trimerization site [polypeptide binding]; other site
340322004868 active site
340322004869 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
340322004870 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
340322004871 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
340322004872 catalytic residue [active]
340322004873 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
340322004874 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
340322004875 Walker A/P-loop; other site
340322004876 ATP binding site [chemical binding]; other site
340322004877 Q-loop/lid; other site
340322004878 ABC transporter signature motif; other site
340322004879 Walker B; other site
340322004880 D-loop; other site
340322004881 H-loop/switch region; other site
340322004882 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
340322004883 FeS assembly protein SufD; Region: sufD; TIGR01981
340322004884 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
340322004885 FeS assembly protein SufB; Region: sufB; TIGR01980
340322004886 Predicted transcriptional regulator [Transcription]; Region: COG2345
340322004887 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
340322004888 putative DNA binding site [nucleotide binding]; other site
340322004889 putative Zn2+ binding site [ion binding]; other site
340322004890 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
340322004891 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
340322004892 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
340322004893 Walker A/P-loop; other site
340322004894 ATP binding site [chemical binding]; other site
340322004895 Q-loop/lid; other site
340322004896 ABC transporter signature motif; other site
340322004897 Walker B; other site
340322004898 D-loop; other site
340322004899 H-loop/switch region; other site
340322004900 ABC-2 type transporter; Region: ABC2_membrane; cl17235
340322004901 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
340322004902 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
340322004903 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
340322004904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4951
340322004905 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
340322004906 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
340322004907 ATP binding site [chemical binding]; other site
340322004908 putative Mg++ binding site [ion binding]; other site
340322004909 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
340322004910 nucleotide binding region [chemical binding]; other site
340322004911 ATP-binding site [chemical binding]; other site
340322004912 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
340322004913 Quinone oxidoreductase (QOR); Region: QOR2; cd05286
340322004914 NADP binding site [chemical binding]; other site
340322004915 dimer interface [polypeptide binding]; other site
340322004916 protoheme IX farnesyltransferase; Provisional; Region: PRK04375
340322004917 UbiA prenyltransferase family; Region: UbiA; pfam01040
340322004918 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
340322004919 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
340322004920 TPP-binding site [chemical binding]; other site
340322004921 dimer interface [polypeptide binding]; other site
340322004922 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
340322004923 PYR/PP interface [polypeptide binding]; other site
340322004924 dimer interface [polypeptide binding]; other site
340322004925 TPP binding site [chemical binding]; other site
340322004926 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
340322004927 putative active site [active]
340322004928 transaldolase; Provisional; Region: PRK03903
340322004929 catalytic residue [active]
340322004930 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
340322004931 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
340322004932 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
340322004933 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
340322004934 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429
340322004935 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
340322004936 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
340322004937 putative active site [active]
340322004938 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
340322004939 hydroxyglutarate oxidase; Provisional; Region: PRK11728
340322004940 ornithine cyclodeaminase; Validated; Region: PRK06199
340322004941 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423
340322004942 ammonium transporter; Region: amt; TIGR00836
340322004943 Preprotein translocase SecG subunit; Region: SecG; cl09123
340322004944 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
340322004945 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
340322004946 triosephosphate isomerase; Provisional; Region: PRK14567
340322004947 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
340322004948 substrate binding site [chemical binding]; other site
340322004949 dimer interface [polypeptide binding]; other site
340322004950 catalytic triad [active]
340322004951 Phosphoglycerate kinase; Region: PGK; pfam00162
340322004952 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
340322004953 substrate binding site [chemical binding]; other site
340322004954 hinge regions; other site
340322004955 ADP binding site [chemical binding]; other site
340322004956 catalytic site [active]
340322004957 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
340322004958 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
340322004959 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
340322004960 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
340322004961 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
340322004962 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
340322004963 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
340322004964 phosphate binding site [ion binding]; other site
340322004965 putative substrate binding pocket [chemical binding]; other site
340322004966 dimer interface [polypeptide binding]; other site
340322004967 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
340322004968 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
340322004969 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
340322004970 GIY-YIG motif/motif A; other site
340322004971 active site
340322004972 catalytic site [active]
340322004973 putative DNA binding site [nucleotide binding]; other site
340322004974 metal binding site [ion binding]; metal-binding site
340322004975 UvrB/uvrC motif; Region: UVR; pfam02151
340322004976 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
340322004977 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
340322004978 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
340322004979 homopentamer interface [polypeptide binding]; other site
340322004980 active site
340322004981 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
340322004982 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
340322004983 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
340322004984 dimerization interface [polypeptide binding]; other site
340322004985 active site
340322004986 riboflavin synthase subunit alpha; Provisional; Region: PRK09289
340322004987 Lumazine binding domain; Region: Lum_binding; pfam00677
340322004988 Lumazine binding domain; Region: Lum_binding; pfam00677
340322004989 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
340322004990 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
340322004991 catalytic motif [active]
340322004992 Zn binding site [ion binding]; other site
340322004993 RibD C-terminal domain; Region: RibD_C; pfam01872
340322004994 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
340322004995 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
340322004996 substrate binding site [chemical binding]; other site
340322004997 hexamer interface [polypeptide binding]; other site
340322004998 metal binding site [ion binding]; metal-binding site
340322004999 16S rRNA methyltransferase B; Provisional; Region: PRK14902
340322005000 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
340322005001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340322005002 S-adenosylmethionine binding site [chemical binding]; other site
340322005003 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
340322005004 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
340322005005 putative active site [active]
340322005006 substrate binding site [chemical binding]; other site
340322005007 putative cosubstrate binding site; other site
340322005008 catalytic site [active]
340322005009 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
340322005010 substrate binding site [chemical binding]; other site
340322005011 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
340322005012 active site
340322005013 catalytic residues [active]
340322005014 metal binding site [ion binding]; metal-binding site
340322005015 primosome assembly protein PriA; Provisional; Region: PRK14873
340322005016 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
340322005017 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
340322005018 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
340322005019 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
340322005020 Flavoprotein; Region: Flavoprotein; pfam02441
340322005021 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
340322005022 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758
340322005023 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
340322005024 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
340322005025 catalytic site [active]
340322005026 G-X2-G-X-G-K; other site
340322005027 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
340322005028 active site
340322005029 dimer interface [polypeptide binding]; other site
340322005030 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
340322005031 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
340322005032 ATP-grasp domain; Region: ATP-grasp_4; cl17255
340322005033 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
340322005034 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
340322005035 ATP-grasp domain; Region: ATP-grasp_4; cl17255
340322005036 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
340322005037 IMP binding site; other site
340322005038 dimer interface [polypeptide binding]; other site
340322005039 interdomain contacts; other site
340322005040 partial ornithine binding site; other site
340322005041 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
340322005042 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
340322005043 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
340322005044 catalytic site [active]
340322005045 subunit interface [polypeptide binding]; other site
340322005046 dihydroorotase; Validated; Region: pyrC; PRK09357
340322005047 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
340322005048 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
340322005049 active site
340322005050 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
340322005051 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
340322005052 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
340322005053 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
340322005054 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
340322005055 active site
340322005056 Uncharacterized conserved protein [Function unknown]; Region: COG4276
340322005057 hydrophobic ligand binding site; other site
340322005058 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
340322005059 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
340322005060 putative NAD(P) binding site [chemical binding]; other site
340322005061 putative active site [active]
340322005062 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
340322005063 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
340322005064 Transcription termination factor [Transcription]; Region: NusB; COG0781
340322005065 putative RNA binding site [nucleotide binding]; other site
340322005066 elongation factor P; Validated; Region: PRK00529
340322005067 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
340322005068 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
340322005069 RNA binding site [nucleotide binding]; other site
340322005070 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
340322005071 RNA binding site [nucleotide binding]; other site
340322005072 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
340322005073 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
340322005074 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
340322005075 active site
340322005076 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
340322005077 active site
340322005078 dimer interface [polypeptide binding]; other site
340322005079 metal binding site [ion binding]; metal-binding site
340322005080 shikimate kinase; Reviewed; Region: aroK; PRK00131
340322005081 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
340322005082 ADP binding site [chemical binding]; other site
340322005083 magnesium binding site [ion binding]; other site
340322005084 putative shikimate binding site; other site
340322005085 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
340322005086 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
340322005087 Tetramer interface [polypeptide binding]; other site
340322005088 active site
340322005089 FMN-binding site [chemical binding]; other site
340322005090 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
340322005091 dimerization interface [polypeptide binding]; other site
340322005092 putative DNA binding site [nucleotide binding]; other site
340322005093 putative Zn2+ binding site [ion binding]; other site
340322005094 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
340322005095 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
340322005096 ABC-ATPase subunit interface; other site
340322005097 dimer interface [polypeptide binding]; other site
340322005098 putative PBP binding regions; other site
340322005099 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
340322005100 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
340322005101 putative ligand binding residues [chemical binding]; other site
340322005102 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
340322005103 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
340322005104 Walker A/P-loop; other site
340322005105 ATP binding site [chemical binding]; other site
340322005106 Q-loop/lid; other site
340322005107 ABC transporter signature motif; other site
340322005108 Walker B; other site
340322005109 D-loop; other site
340322005110 H-loop/switch region; other site
340322005111 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
340322005112 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
340322005113 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
340322005114 shikimate binding site; other site
340322005115 NAD(P) binding site [chemical binding]; other site
340322005116 YceG-like family; Region: YceG; pfam02618
340322005117 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
340322005118 dimerization interface [polypeptide binding]; other site
340322005119 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
340322005120 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
340322005121 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
340322005122 motif 1; other site
340322005123 active site
340322005124 motif 2; other site
340322005125 motif 3; other site
340322005126 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
340322005127 recombination factor protein RarA; Reviewed; Region: PRK13342
340322005128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340322005129 Walker A motif; other site
340322005130 ATP binding site [chemical binding]; other site
340322005131 Walker B motif; other site
340322005132 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
340322005133 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
340322005134 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
340322005135 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
340322005136 dimer interface [polypeptide binding]; other site
340322005137 anticodon binding site; other site
340322005138 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
340322005139 homodimer interface [polypeptide binding]; other site
340322005140 motif 1; other site
340322005141 active site
340322005142 motif 2; other site
340322005143 GAD domain; Region: GAD; pfam02938
340322005144 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
340322005145 active site
340322005146 motif 3; other site
340322005147 Predicted metalloprotease [General function prediction only]; Region: COG2321
340322005148 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
340322005149 DEAD-like helicases superfamily; Region: DEXDc; smart00487
340322005150 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
340322005151 ATP binding site [chemical binding]; other site
340322005152 putative Mg++ binding site [ion binding]; other site
340322005153 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
340322005154 nucleotide binding region [chemical binding]; other site
340322005155 ATP-binding site [chemical binding]; other site
340322005156 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
340322005157 Predicted membrane protein [Function unknown]; Region: COG1511
340322005158 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
340322005159 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
340322005160 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
340322005161 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322005162 Q-loop/lid; other site
340322005163 ABC transporter signature motif; other site
340322005164 Walker B; other site
340322005165 D-loop; other site
340322005166 H-loop/switch region; other site
340322005167 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
340322005168 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
340322005169 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
340322005170 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
340322005171 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
340322005172 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
340322005173 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037
340322005174 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
340322005175 Serine dehydratase beta chain; Region: SDH_beta; pfam03315
340322005176 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
340322005177 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
340322005178 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
340322005179 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
340322005180 dimer interface [polypeptide binding]; other site
340322005181 motif 1; other site
340322005182 active site
340322005183 motif 2; other site
340322005184 motif 3; other site
340322005185 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
340322005186 anticodon binding site; other site
340322005187 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
340322005188 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
340322005189 active site
340322005190 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
340322005191 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
340322005192 Zn2+ binding site [ion binding]; other site
340322005193 Mg2+ binding site [ion binding]; other site
340322005194 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
340322005195 synthetase active site [active]
340322005196 NTP binding site [chemical binding]; other site
340322005197 metal binding site [ion binding]; metal-binding site
340322005198 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
340322005199 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
340322005200 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
340322005201 active site
340322005202 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
340322005203 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
340322005204 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
340322005205 Protein export membrane protein; Region: SecD_SecF; cl14618
340322005206 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342
340322005207 Protein export membrane protein; Region: SecD_SecF; cl14618
340322005208 Preprotein translocase subunit; Region: YajC; pfam02699
340322005209 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
340322005210 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340322005211 Walker A motif; other site
340322005212 ATP binding site [chemical binding]; other site
340322005213 Walker B motif; other site
340322005214 arginine finger; other site
340322005215 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
340322005216 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632
340322005217 RuvA N terminal domain; Region: RuvA_N; pfam01330
340322005218 RuvA, C-terminal domain; Region: RuvA_C; pfam07499
340322005219 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
340322005220 active site
340322005221 putative DNA-binding cleft [nucleotide binding]; other site
340322005222 dimer interface [polypeptide binding]; other site
340322005223 hypothetical protein; Validated; Region: PRK00110
340322005224 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
340322005225 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
340322005226 active site
340322005227 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
340322005228 catalytic triad [active]
340322005229 dimer interface [polypeptide binding]; other site
340322005230 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
340322005231 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
340322005232 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
340322005233 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
340322005234 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
340322005235 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
340322005236 putative acyl-acceptor binding pocket; other site
340322005237 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
340322005238 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
340322005239 nucleotide binding site/active site [active]
340322005240 HIT family signature motif; other site
340322005241 catalytic residue [active]
340322005242 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
340322005243 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
340322005244 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
340322005245 active site
340322005246 dimer interface [polypeptide binding]; other site
340322005247 motif 1; other site
340322005248 motif 2; other site
340322005249 motif 3; other site
340322005250 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
340322005251 anticodon binding site; other site
340322005252 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
340322005253 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372
340322005254 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
340322005255 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
340322005256 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
340322005257 hypothetical protein; Provisional; Region: PRK14059
340322005258 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
340322005259 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
340322005260 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
340322005261 SelR domain; Region: SelR; pfam01641
340322005262 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
340322005263 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
340322005264 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
340322005265 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
340322005266 catalytic site [active]
340322005267 putative active site [active]
340322005268 putative substrate binding site [chemical binding]; other site
340322005269 HRDC domain; Region: HRDC; pfam00570
340322005270 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154
340322005271 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
340322005272 TPP-binding site; other site
340322005273 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
340322005274 PYR/PP interface [polypeptide binding]; other site
340322005275 dimer interface [polypeptide binding]; other site
340322005276 TPP binding site [chemical binding]; other site
340322005277 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
340322005278 TRAM domain; Region: TRAM; pfam01938
340322005279 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
340322005280 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
340322005281 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
340322005282 trimer interface [polypeptide binding]; other site
340322005283 active site
340322005284 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
340322005285 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
340322005286 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
340322005287 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
340322005288 active site
340322005289 dimerization interface [polypeptide binding]; other site
340322005290 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
340322005291 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
340322005292 nucleotide binding site [chemical binding]; other site
340322005293 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
340322005294 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
340322005295 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
340322005296 Sigma-70 region 3; Region: Sigma70_r3; pfam04539
340322005297 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
340322005298 DNA binding residues [nucleotide binding]
340322005299 Predicted membrane protein [Function unknown]; Region: COG2311
340322005300 Protein of unknown function (DUF418); Region: DUF418; cl12135
340322005301 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
340322005302 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
340322005303 ATP binding site [chemical binding]; other site
340322005304 putative Mg++ binding site [ion binding]; other site
340322005305 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
340322005306 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
340322005307 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
340322005308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340322005309 S-adenosylmethionine binding site [chemical binding]; other site
340322005310 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
340322005311 putative active site [active]
340322005312 dimerization interface [polypeptide binding]; other site
340322005313 putative tRNAtyr binding site [nucleotide binding]; other site
340322005314 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
340322005315 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
340322005316 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
340322005317 Sigma-70 region 3; Region: Sigma70_r3; pfam04539
340322005318 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
340322005319 DNA binding residues [nucleotide binding]
340322005320 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
340322005321 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
340322005322 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
340322005323 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
340322005324 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
340322005325 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
340322005326 NAD binding site [chemical binding]; other site
340322005327 homodimer interface [polypeptide binding]; other site
340322005328 active site
340322005329 substrate binding site [chemical binding]; other site
340322005330 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
340322005331 PAC2 family; Region: PAC2; pfam09754
340322005332 DEAD-like helicases superfamily; Region: DEXDc; smart00487
340322005333 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
340322005334 ATP binding site [chemical binding]; other site
340322005335 putative Mg++ binding site [ion binding]; other site
340322005336 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
340322005337 nucleotide binding region [chemical binding]; other site
340322005338 ATP-binding site [chemical binding]; other site
340322005339 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
340322005340 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
340322005341 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
340322005342 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
340322005343 dimerization interface [polypeptide binding]; other site
340322005344 Predicted integral membrane protein [Function unknown]; Region: COG5473
340322005345 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
340322005346 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
340322005347 ATP binding site [chemical binding]; other site
340322005348 putative Mg++ binding site [ion binding]; other site
340322005349 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
340322005350 nucleotide binding region [chemical binding]; other site
340322005351 ATP-binding site [chemical binding]; other site
340322005352 Helicase associated domain (HA2); Region: HA2; pfam04408
340322005353 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
340322005354 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
340322005355 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
340322005356 ATP cone domain; Region: ATP-cone; pfam03477
340322005357 LexA repressor; Validated; Region: PRK00215
340322005358 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
340322005359 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
340322005360 Catalytic site [active]
340322005361 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
340322005362 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
340322005363 DeoR C terminal sensor domain; Region: DeoRC; pfam00455
340322005364 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
340322005365 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
340322005366 substrate binding site [chemical binding]; other site
340322005367 ATP binding site [chemical binding]; other site
340322005368 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
340322005369 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
340322005370 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
340322005371 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
340322005372 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
340322005373 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
340322005374 DeoR C terminal sensor domain; Region: DeoRC; pfam00455
340322005375 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
340322005376 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
340322005377 putative substrate binding site [chemical binding]; other site
340322005378 putative ATP binding site [chemical binding]; other site
340322005379 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
340322005380 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
340322005381 active site
340322005382 phosphorylation site [posttranslational modification]
340322005383 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
340322005384 active site
340322005385 P-loop; other site
340322005386 phosphorylation site [posttranslational modification]
340322005387 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
340322005388 Phosphotransferase System HPr (HPr) Family; Region: PTS_HPr_family; TIGR01003
340322005389 dimerization domain swap beta strand [polypeptide binding]; other site
340322005390 regulatory protein interface [polypeptide binding]; other site
340322005391 active site
340322005392 regulatory phosphorylation site [posttranslational modification]; other site
340322005393 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978
340322005394 pyrimidine utilization transport protein G; Region: RutG; TIGR03616
340322005395 GTPases [General function prediction only]; Region: HflX; COG2262
340322005396 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
340322005397 HflX GTPase family; Region: HflX; cd01878
340322005398 G1 box; other site
340322005399 GTP/Mg2+ binding site [chemical binding]; other site
340322005400 Switch I region; other site
340322005401 G2 box; other site
340322005402 G3 box; other site
340322005403 Switch II region; other site
340322005404 G4 box; other site
340322005405 G5 box; other site
340322005406 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
340322005407 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
340322005408 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
340322005409 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
340322005410 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
340322005411 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
340322005412 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
340322005413 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
340322005414 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
340322005415 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
340322005416 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
340322005417 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
340322005418 FeS/SAM binding site; other site
340322005419 TRAM domain; Region: TRAM; cl01282
340322005420 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
340322005421 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
340322005422 Walker A/P-loop; other site
340322005423 ATP binding site [chemical binding]; other site
340322005424 Q-loop/lid; other site
340322005425 ABC transporter signature motif; other site
340322005426 Walker B; other site
340322005427 D-loop; other site
340322005428 H-loop/switch region; other site
340322005429 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
340322005430 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
340322005431 substrate binding pocket [chemical binding]; other site
340322005432 membrane-bound complex binding site; other site
340322005433 hinge residues; other site
340322005434 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
340322005435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322005436 dimer interface [polypeptide binding]; other site
340322005437 conserved gate region; other site
340322005438 putative PBP binding loops; other site
340322005439 ABC-ATPase subunit interface; other site
340322005440 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
340322005441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322005442 dimer interface [polypeptide binding]; other site
340322005443 conserved gate region; other site
340322005444 putative PBP binding loops; other site
340322005445 ABC-ATPase subunit interface; other site
340322005446 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137
340322005447 recombinase A; Provisional; Region: recA; PRK09354
340322005448 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
340322005449 hexamer interface [polypeptide binding]; other site
340322005450 Walker A motif; other site
340322005451 ATP binding site [chemical binding]; other site
340322005452 Walker B motif; other site
340322005453 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
340322005454 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
340322005455 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
340322005456 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
340322005457 Walker A/P-loop; other site
340322005458 ATP binding site [chemical binding]; other site
340322005459 Q-loop/lid; other site
340322005460 ABC transporter signature motif; other site
340322005461 Walker B; other site
340322005462 D-loop; other site
340322005463 H-loop/switch region; other site
340322005464 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
340322005465 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
340322005466 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340322005467 non-specific DNA binding site [nucleotide binding]; other site
340322005468 salt bridge; other site
340322005469 sequence-specific DNA binding site [nucleotide binding]; other site
340322005470 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
340322005471 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
340322005472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350
340322005473 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
340322005474 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
340322005475 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
340322005476 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
340322005477 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
340322005478 TIGR03085 family protein; Region: TIGR03085
340322005479 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
340322005480 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
340322005481 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
340322005482 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
340322005483 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
340322005484 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
340322005485 dimer interface [polypeptide binding]; other site
340322005486 active site
340322005487 catalytic residue [active]
340322005488 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
340322005489 dihydrodipicolinate reductase; Provisional; Region: PRK00048
340322005490 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
340322005491 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
340322005492 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
340322005493 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
340322005494 oligomer interface [polypeptide binding]; other site
340322005495 RNA binding site [nucleotide binding]; other site
340322005496 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
340322005497 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
340322005498 RNase E interface [polypeptide binding]; other site
340322005499 trimer interface [polypeptide binding]; other site
340322005500 active site
340322005501 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
340322005502 putative nucleic acid binding region [nucleotide binding]; other site
340322005503 G-X-X-G motif; other site
340322005504 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
340322005505 RNA binding site [nucleotide binding]; other site
340322005506 domain interface; other site
340322005507 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
340322005508 16S/18S rRNA binding site [nucleotide binding]; other site
340322005509 S13e-L30e interaction site [polypeptide binding]; other site
340322005510 25S rRNA binding site [nucleotide binding]; other site
340322005511 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
340322005512 active site
340322005513 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
340322005514 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
340322005515 active site
340322005516 Riboflavin kinase; Region: Flavokinase; smart00904
340322005517 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
340322005518 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
340322005519 RNA binding site [nucleotide binding]; other site
340322005520 active site
340322005521 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
340322005522 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
340322005523 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
340322005524 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
340322005525 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
340322005526 active site
340322005527 metal binding site [ion binding]; metal-binding site
340322005528 putative phosphoesterase; Region: acc_ester; TIGR03729
340322005529 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
340322005530 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
340322005531 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
340322005532 DHH family; Region: DHH; pfam01368
340322005533 ribosome-binding factor A; Validated; Region: rbfA; PRK00521
340322005534 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
340322005535 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
340322005536 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
340322005537 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
340322005538 G1 box; other site
340322005539 putative GEF interaction site [polypeptide binding]; other site
340322005540 GTP/Mg2+ binding site [chemical binding]; other site
340322005541 Switch I region; other site
340322005542 G2 box; other site
340322005543 G3 box; other site
340322005544 Switch II region; other site
340322005545 G4 box; other site
340322005546 G5 box; other site
340322005547 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
340322005548 Translation-initiation factor 2; Region: IF-2; pfam11987
340322005549 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
340322005550 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
340322005551 putative RNA binding cleft [nucleotide binding]; other site
340322005552 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
340322005553 NusA N-terminal domain; Region: NusA_N; pfam08529
340322005554 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
340322005555 RNA binding site [nucleotide binding]; other site
340322005556 homodimer interface [polypeptide binding]; other site
340322005557 NusA-like KH domain; Region: KH_5; pfam13184
340322005558 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
340322005559 G-X-X-G motif; other site
340322005560 ribosome maturation protein RimP; Reviewed; Region: PRK00092
340322005561 Sm and related proteins; Region: Sm_like; cl00259
340322005562 Sm and related proteins; Region: Sm_like; cl00259
340322005563 heptamer interface [polypeptide binding]; other site
340322005564 Sm1 motif; other site
340322005565 hexamer interface [polypeptide binding]; other site
340322005566 RNA binding site [nucleotide binding]; other site
340322005567 Sm2 motif; other site
340322005568 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
340322005569 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
340322005570 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
340322005571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322005572 dimer interface [polypeptide binding]; other site
340322005573 conserved gate region; other site
340322005574 ABC-ATPase subunit interface; other site
340322005575 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
340322005576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322005577 dimer interface [polypeptide binding]; other site
340322005578 conserved gate region; other site
340322005579 putative PBP binding loops; other site
340322005580 ABC-ATPase subunit interface; other site
340322005581 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
340322005582 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
340322005583 Walker A/P-loop; other site
340322005584 ATP binding site [chemical binding]; other site
340322005585 Q-loop/lid; other site
340322005586 ABC transporter signature motif; other site
340322005587 Walker B; other site
340322005588 D-loop; other site
340322005589 H-loop/switch region; other site
340322005590 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
340322005591 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
340322005592 Walker A/P-loop; other site
340322005593 ATP binding site [chemical binding]; other site
340322005594 Q-loop/lid; other site
340322005595 ABC transporter signature motif; other site
340322005596 Walker B; other site
340322005597 D-loop; other site
340322005598 H-loop/switch region; other site
340322005599 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
340322005600 prolyl-tRNA synthetase; Provisional; Region: PRK09194
340322005601 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
340322005602 dimer interface [polypeptide binding]; other site
340322005603 motif 1; other site
340322005604 active site
340322005605 motif 2; other site
340322005606 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
340322005607 putative deacylase active site [active]
340322005608 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
340322005609 active site
340322005610 motif 3; other site
340322005611 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
340322005612 anticodon binding site; other site
340322005613 hypothetical protein; Validated; Region: PRK02101
340322005614 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240
340322005615 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
340322005616 metal ion-dependent adhesion site (MIDAS); other site
340322005617 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
340322005618 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340322005619 Walker A motif; other site
340322005620 ATP binding site [chemical binding]; other site
340322005621 Walker B motif; other site
340322005622 arginine finger; other site
340322005623 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
340322005624 active site
340322005625 SAM binding site [chemical binding]; other site
340322005626 homodimer interface [polypeptide binding]; other site
340322005627 Uncharacterized conserved protein [Function unknown]; Region: COG0397
340322005628 hypothetical protein; Validated; Region: PRK00029
340322005629 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
340322005630 dimer interface [polypeptide binding]; other site
340322005631 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
340322005632 dimer interface [polypeptide binding]; other site
340322005633 malate:quinone oxidoreductase; Validated; Region: PRK05257
340322005634 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
340322005635 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
340322005636 Putative lysophospholipase; Region: Hydrolase_4; pfam12146
340322005637 mycothione reductase; Region: mycothione_red; TIGR03452
340322005638 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
340322005639 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
340322005640 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
340322005641 active site
340322005642 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
340322005643 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
340322005644 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
340322005645 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
340322005646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
340322005647 active site
340322005648 phosphorylation site [posttranslational modification]
340322005649 intermolecular recognition site; other site
340322005650 dimerization interface [polypeptide binding]; other site
340322005651 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
340322005652 DNA binding residues [nucleotide binding]
340322005653 dimerization interface [polypeptide binding]; other site
340322005654 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
340322005655 Histidine kinase; Region: HisKA_3; pfam07730
340322005656 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
340322005657 Mg2+ binding site [ion binding]; other site
340322005658 G-X-G motif; other site
340322005659 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
340322005660 FtsX-like permease family; Region: FtsX; pfam02687
340322005661 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
340322005662 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
340322005663 Walker A/P-loop; other site
340322005664 ATP binding site [chemical binding]; other site
340322005665 Q-loop/lid; other site
340322005666 ABC transporter signature motif; other site
340322005667 Walker B; other site
340322005668 D-loop; other site
340322005669 H-loop/switch region; other site
340322005670 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
340322005671 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
340322005672 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
340322005673 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
340322005674 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
340322005675 active site
340322005676 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
340322005677 protein binding site [polypeptide binding]; other site
340322005678 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
340322005679 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
340322005680 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
340322005681 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
340322005682 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939
340322005683 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
340322005684 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
340322005685 Walker A/P-loop; other site
340322005686 ATP binding site [chemical binding]; other site
340322005687 Q-loop/lid; other site
340322005688 ABC transporter signature motif; other site
340322005689 Walker B; other site
340322005690 D-loop; other site
340322005691 H-loop/switch region; other site
340322005692 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
340322005693 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
340322005694 FeS/SAM binding site; other site
340322005695 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
340322005696 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
340322005697 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
340322005698 ribosome recycling factor; Reviewed; Region: frr; PRK00083
340322005699 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
340322005700 hinge region; other site
340322005701 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
340322005702 putative nucleotide binding site [chemical binding]; other site
340322005703 uridine monophosphate binding site [chemical binding]; other site
340322005704 homohexameric interface [polypeptide binding]; other site
340322005705 elongation factor Ts; Provisional; Region: tsf; PRK09377
340322005706 UBA/TS-N domain; Region: UBA; pfam00627
340322005707 Elongation factor TS; Region: EF_TS; pfam00889
340322005708 Elongation factor TS; Region: EF_TS; pfam00889
340322005709 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
340322005710 rRNA interaction site [nucleotide binding]; other site
340322005711 S8 interaction site; other site
340322005712 putative laminin-1 binding site; other site
340322005713 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
340322005714 Peptidase family M23; Region: Peptidase_M23; pfam01551
340322005715 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
340322005716 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
340322005717 active site
340322005718 DNA binding site [nucleotide binding]
340322005719 Int/Topo IB signature motif; other site
340322005720 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
340322005721 DNA protecting protein DprA; Region: dprA; TIGR00732
340322005722 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
340322005723 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
340322005724 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
340322005725 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
340322005726 hypothetical protein; Reviewed; Region: PRK12497
340322005727 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
340322005728 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
340322005729 RNA/DNA hybrid binding site [nucleotide binding]; other site
340322005730 active site
340322005731 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
340322005732 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
340322005733 Catalytic site [active]
340322005734 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
340322005735 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
340322005736 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
340322005737 siderophore binding site; other site
340322005738 CsbD-like; Region: CsbD; pfam05532
340322005739 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
340322005740 helix-hairpin-helix signature motif; other site
340322005741 substrate binding pocket [chemical binding]; other site
340322005742 active site
340322005743 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712
340322005744 amidase catalytic site [active]
340322005745 Zn binding residues [ion binding]; other site
340322005746 substrate binding site [chemical binding]; other site
340322005747 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
340322005748 Phage-related protein [Function unknown]; Region: COG5412
340322005749 membrane protein P6; Region: PHA01399
340322005750 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
340322005751 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254
340322005752 N-acetyl-D-glucosamine binding site [chemical binding]; other site
340322005753 catalytic residue [active]
340322005754 Phage protein Gp19/Gp15/Gp42; Region: Phage_Gp19; pfam09355
340322005755 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
340322005756 oligomer interface [polypeptide binding]; other site
340322005757 active site residues [active]
340322005758 Phage Terminase; Region: Terminase_1; pfam03354
340322005759 Phage terminase, small subunit; Region: Terminase_4; cl01525
340322005760 Restriction endonuclease; Region: Mrr_cat; pfam04471
340322005761 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
340322005762 catalytic site [active]
340322005763 putative active site [active]
340322005764 putative substrate binding site [chemical binding]; other site
340322005765 dimer interface [polypeptide binding]; other site
340322005766 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
340322005767 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
340322005768 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
340322005769 dimer interface [polypeptide binding]; other site
340322005770 ssDNA binding site [nucleotide binding]; other site
340322005771 tetramer (dimer of dimers) interface [polypeptide binding]; other site
340322005772 Prophage antirepressor [Transcription]; Region: COG3617
340322005773 BRO family, N-terminal domain; Region: Bro-N; smart01040
340322005774 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
340322005775 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
340322005776 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
340322005777 sequence-specific DNA binding site [nucleotide binding]; other site
340322005778 salt bridge; other site
340322005779 Domain of unknown function (DUF955); Region: DUF955; pfam06114
340322005780 TM2 domain; Region: TM2; pfam05154
340322005781 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
340322005782 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
340322005783 Int/Topo IB signature motif; other site
340322005784 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
340322005785 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
340322005786 active site
340322005787 pyrophosphate binding site [ion binding]; other site
340322005788 thiamine phosphate binding site [chemical binding]; other site
340322005789 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
340322005790 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
340322005791 thiS-thiF/thiG interaction site; other site
340322005792 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
340322005793 ThiS interaction site; other site
340322005794 putative active site [active]
340322005795 tetramer interface [polypeptide binding]; other site
340322005796 thiamine biosynthesis protein ThiF; Validated; Region: PRK05600
340322005797 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
340322005798 ATP binding site [chemical binding]; other site
340322005799 substrate interface [chemical binding]; other site
340322005800 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
340322005801 active site residue [active]
340322005802 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
340322005803 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
340322005804 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
340322005805 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
340322005806 RNA binding site [nucleotide binding]; other site
340322005807 Transcriptional regulators [Transcription]; Region: PurR; COG1609
340322005808 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
340322005809 DNA binding site [nucleotide binding]
340322005810 domain linker motif; other site
340322005811 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
340322005812 dimerization interface [polypeptide binding]; other site
340322005813 ligand binding site [chemical binding]; other site
340322005814 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
340322005815 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
340322005816 transmembrane helices; other site
340322005817 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
340322005818 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
340322005819 tetramer interface [polypeptide binding]; other site
340322005820 active site
340322005821 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
340322005822 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
340322005823 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
340322005824 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
340322005825 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
340322005826 RimM N-terminal domain; Region: RimM; pfam01782
340322005827 PRC-barrel domain; Region: PRC; pfam05239
340322005828 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
340322005829 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
340322005830 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
340322005831 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
340322005832 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
340322005833 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
340322005834 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322005835 Walker A/P-loop; other site
340322005836 ATP binding site [chemical binding]; other site
340322005837 Q-loop/lid; other site
340322005838 ABC transporter signature motif; other site
340322005839 Walker B; other site
340322005840 D-loop; other site
340322005841 H-loop/switch region; other site
340322005842 signal recognition particle protein; Provisional; Region: PRK10867
340322005843 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
340322005844 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
340322005845 P loop; other site
340322005846 GTP binding site [chemical binding]; other site
340322005847 Signal peptide binding domain; Region: SRP_SPB; pfam02978
340322005848 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227
340322005849 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
340322005850 metal binding triad; other site
340322005851 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
340322005852 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
340322005853 Zn2+ binding site [ion binding]; other site
340322005854 Mg2+ binding site [ion binding]; other site
340322005855 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
340322005856 Nitrogen regulatory protein P-II; Region: P-II; smart00938
340322005857 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
340322005858 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
340322005859 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
340322005860 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
340322005861 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
340322005862 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
340322005863 Walker A/P-loop; other site
340322005864 ATP binding site [chemical binding]; other site
340322005865 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
340322005866 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
340322005867 ABC transporter signature motif; other site
340322005868 Walker B; other site
340322005869 D-loop; other site
340322005870 H-loop/switch region; other site
340322005871 acylphosphatase; Provisional; Region: PRK14422
340322005872 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
340322005873 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
340322005874 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
340322005875 Transcriptional regulator [Transcription]; Region: LysR; COG0583
340322005876 dimerization interface [polypeptide binding]; other site
340322005877 Sulfite exporter TauE/SafE; Region: TauE; pfam01925
340322005878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815
340322005879 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
340322005880 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
340322005881 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
340322005882 DNA binding site [nucleotide binding]
340322005883 catalytic residue [active]
340322005884 H2TH interface [polypeptide binding]; other site
340322005885 putative catalytic residues [active]
340322005886 turnover-facilitating residue; other site
340322005887 intercalation triad [nucleotide binding]; other site
340322005888 8OG recognition residue [nucleotide binding]; other site
340322005889 putative reading head residues; other site
340322005890 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
340322005891 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
340322005892 ribonuclease III; Reviewed; Region: rnc; PRK00102
340322005893 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
340322005894 dimerization interface [polypeptide binding]; other site
340322005895 active site
340322005896 metal binding site [ion binding]; metal-binding site
340322005897 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
340322005898 dsRNA binding site [nucleotide binding]; other site
340322005899 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
340322005900 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
340322005901 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
340322005902 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
340322005903 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
340322005904 Walker A/P-loop; other site
340322005905 ATP binding site [chemical binding]; other site
340322005906 Q-loop/lid; other site
340322005907 ABC transporter signature motif; other site
340322005908 Walker B; other site
340322005909 D-loop; other site
340322005910 H-loop/switch region; other site
340322005911 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
340322005912 Walker A/P-loop; other site
340322005913 ATP binding site [chemical binding]; other site
340322005914 ABC transporter; Region: ABC_tran; pfam00005
340322005915 Q-loop/lid; other site
340322005916 ABC transporter signature motif; other site
340322005917 Walker B; other site
340322005918 D-loop; other site
340322005919 H-loop/switch region; other site
340322005920 glutamate dehydrogenase; Provisional; Region: PRK09414
340322005921 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
340322005922 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
340322005923 NAD(P) binding site [chemical binding]; other site
340322005924 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
340322005925 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
340322005926 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
340322005927 nucleotide binding site/active site [active]
340322005928 HIT family signature motif; other site
340322005929 catalytic residue [active]
340322005930 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
340322005931 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
340322005932 metal binding site [ion binding]; metal-binding site
340322005933 putative dimer interface [polypeptide binding]; other site
340322005934 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
340322005935 putative homodimer interface [polypeptide binding]; other site
340322005936 putative active site pocket [active]
340322005937 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
340322005938 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
340322005939 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
340322005940 putative metal binding site [ion binding]; other site
340322005941 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
340322005942 active site
340322005943 pyruvate kinase; Provisional; Region: PRK06247
340322005944 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
340322005945 domain interfaces; other site
340322005946 active site
340322005947 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
340322005948 Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Region: TrpC; COG0134
340322005949 phosphate binding site [ion binding]; other site
340322005950 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534
340322005951 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
340322005952 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
340322005953 Histidine biosynthesis protein; Region: His_biosynth; pfam00977
340322005954 substrate binding site [chemical binding]; other site
340322005955 glutamase interaction surface [polypeptide binding]; other site
340322005956 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
340322005957 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
340322005958 active site
340322005959 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
340322005960 Histidine biosynthesis protein; Region: His_biosynth; pfam00977
340322005961 catalytic residues [active]
340322005962 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
340322005963 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
340322005964 putative active site [active]
340322005965 oxyanion strand; other site
340322005966 catalytic triad [active]
340322005967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322005968 Major Facilitator Superfamily; Region: MFS_1; pfam07690
340322005969 putative substrate translocation pore; other site
340322005970 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
340322005971 putative active site pocket [active]
340322005972 4-fold oligomerization interface [polypeptide binding]; other site
340322005973 metal binding residues [ion binding]; metal-binding site
340322005974 3-fold/trimer interface [polypeptide binding]; other site
340322005975 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
340322005976 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
340322005977 pyridoxal 5'-phosphate binding site [chemical binding]; other site
340322005978 homodimer interface [polypeptide binding]; other site
340322005979 catalytic residue [active]
340322005980 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
340322005981 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
340322005982 NAD binding site [chemical binding]; other site
340322005983 dimerization interface [polypeptide binding]; other site
340322005984 product binding site; other site
340322005985 substrate binding site [chemical binding]; other site
340322005986 zinc binding site [ion binding]; other site
340322005987 catalytic residues [active]
340322005988 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
340322005989 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
340322005990 tetracycline repressor protein TetR; Provisional; Region: PRK13756
340322005991 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
340322005992 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
340322005993 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
340322005994 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
340322005995 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
340322005996 active site
340322005997 catalytic site [active]
340322005998 Methyltransferase domain; Region: Methyltransf_23; pfam13489
340322005999 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340322006000 S-adenosylmethionine binding site [chemical binding]; other site
340322006001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
340322006002 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
340322006003 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
340322006004 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
340322006005 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
340322006006 Transcriptional regulators [Transcription]; Region: PurR; COG1609
340322006007 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
340322006008 DNA binding site [nucleotide binding]
340322006009 domain linker motif; other site
340322006010 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
340322006011 dimerization interface [polypeptide binding]; other site
340322006012 ligand binding site [chemical binding]; other site
340322006013 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
340322006014 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
340322006015 Walker A/P-loop; other site
340322006016 ATP binding site [chemical binding]; other site
340322006017 Q-loop/lid; other site
340322006018 ABC transporter signature motif; other site
340322006019 Walker B; other site
340322006020 D-loop; other site
340322006021 H-loop/switch region; other site
340322006022 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
340322006023 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
340322006024 ABC-ATPase subunit interface; other site
340322006025 dimer interface [polypeptide binding]; other site
340322006026 putative PBP binding regions; other site
340322006027 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
340322006028 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
340322006029 putative binding site residues; other site
340322006030 Predicted transcriptional regulators [Transcription]; Region: COG1733
340322006031 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
340322006032 dimerization interface [polypeptide binding]; other site
340322006033 putative DNA binding site [nucleotide binding]; other site
340322006034 putative Zn2+ binding site [ion binding]; other site
340322006035 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
340322006036 active site
340322006037 catalytic site [active]
340322006038 substrate binding site [chemical binding]; other site
340322006039 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280
340322006040 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
340322006041 active site
340322006042 catalytic site [active]
340322006043 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
340322006044 synthetase active site [active]
340322006045 NTP binding site [chemical binding]; other site
340322006046 metal binding site [ion binding]; metal-binding site
340322006047 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
340322006048 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
340322006049 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
340322006050 RNA binding surface [nucleotide binding]; other site
340322006051 Uncharacterized conserved protein [Function unknown]; Region: COG1739
340322006052 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
340322006053 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
340322006054 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
340322006055 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
340322006056 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
340322006057 catalytic site [active]
340322006058 active site
340322006059 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
340322006060 threonine dehydratase; Validated; Region: PRK08639
340322006061 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
340322006062 tetramer interface [polypeptide binding]; other site
340322006063 pyridoxal 5'-phosphate binding site [chemical binding]; other site
340322006064 catalytic residue [active]
340322006065 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
340322006066 putative Ile/Val binding site [chemical binding]; other site
340322006067 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
340322006068 substrate binding site [chemical binding]; other site
340322006069 THF binding site; other site
340322006070 zinc-binding site [ion binding]; other site
340322006071 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
340322006072 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
340322006073 active site
340322006074 PHP Thumb interface [polypeptide binding]; other site
340322006075 metal binding site [ion binding]; metal-binding site
340322006076 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
340322006077 generic binding surface II; other site
340322006078 generic binding surface I; other site
340322006079 Predicted permeases [General function prediction only]; Region: RarD; COG2962
340322006080 EamA-like transporter family; Region: EamA; cl17759
340322006081 EamA-like transporter family; Region: EamA; cl17759
340322006082 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
340322006083 Cation efflux family; Region: Cation_efflux; pfam01545
340322006084 oxidoreductase; Provisional; Region: PRK06128
340322006085 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
340322006086 NAD(P) binding site [chemical binding]; other site
340322006087 active site
340322006088 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
340322006089 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
340322006090 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
340322006091 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842
340322006092 dimer interface [polypeptide binding]; other site
340322006093 active site
340322006094 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
340322006095 catalytic residues [active]
340322006096 substrate binding site [chemical binding]; other site
340322006097 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
340322006098 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
340322006099 dimer interface [polypeptide binding]; other site
340322006100 pyridoxal 5'-phosphate binding site [chemical binding]; other site
340322006101 catalytic residue [active]
340322006102 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
340322006103 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
340322006104 active site
340322006105 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
340322006106 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
340322006107 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322006108 Walker A/P-loop; other site
340322006109 ATP binding site [chemical binding]; other site
340322006110 Q-loop/lid; other site
340322006111 ABC transporter signature motif; other site
340322006112 Walker B; other site
340322006113 D-loop; other site
340322006114 H-loop/switch region; other site
340322006115 ABC transporter; Region: ABC_tran_2; pfam12848
340322006116 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
340322006117 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
340322006118 active site
340322006119 homotetramer interface [polypeptide binding]; other site
340322006120 homodimer interface [polypeptide binding]; other site
340322006121 DNA polymerase IV; Provisional; Region: PRK03348
340322006122 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
340322006123 active site
340322006124 DNA binding site [nucleotide binding]
340322006125 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
340322006126 HEAT repeats; Region: HEAT_2; pfam13646
340322006127 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788
340322006128 MerR HTH family regulatory protein; Region: MerR_1; pfam13411
340322006129 DNA binding residues [nucleotide binding]
340322006130 putative dimer interface [polypeptide binding]; other site
340322006131 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
340322006132 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
340322006133 HIGH motif; other site
340322006134 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
340322006135 active site
340322006136 KMSKS motif; other site
340322006137 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
340322006138 tRNA binding surface [nucleotide binding]; other site
340322006139 anticodon binding site; other site
340322006140 DivIVA protein; Region: DivIVA; pfam05103
340322006141 DivIVA domain; Region: DivI1A_domain; TIGR03544
340322006142 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
340322006143 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525
340322006144 Predicted integral membrane protein [Function unknown]; Region: COG0762
340322006145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
340322006146 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
340322006147 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
340322006148 catalytic residue [active]
340322006149 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
340322006150 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
340322006151 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
340322006152 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
340322006153 nucleotide binding site [chemical binding]; other site
340322006154 SulA interaction site; other site
340322006155 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
340322006156 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
340322006157 Cell division protein FtsQ; Region: FtsQ; pfam03799
340322006158 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
340322006159 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
340322006160 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
340322006161 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
340322006162 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
340322006163 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
340322006164 active site
340322006165 homodimer interface [polypeptide binding]; other site
340322006166 cell division protein FtsW; Region: ftsW; TIGR02614
340322006167 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141
340322006168 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
340322006169 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
340322006170 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
340322006171 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
340322006172 Mg++ binding site [ion binding]; other site
340322006173 putative catalytic motif [active]
340322006174 putative substrate binding site [chemical binding]; other site
340322006175 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
340322006176 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
340322006177 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
340322006178 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
340322006179 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
340322006180 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
340322006181 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
340322006182 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
340322006183 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
340322006184 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
340322006185 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
340322006186 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
340322006187 MraW methylase family; Region: Methyltransf_5; cl17771
340322006188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
340322006189 MraZ protein; Region: MraZ; pfam02381
340322006190 MraZ protein; Region: MraZ; pfam02381
340322006191 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
340322006192 Acetyltransferases [General function prediction only]; Region: RimI; COG0456
340322006193 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
340322006194 Coenzyme A binding pocket [chemical binding]; other site
340322006195 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
340322006196 FAD binding site [chemical binding]; other site
340322006197 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
340322006198 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
340322006199 substrate binding pocket [chemical binding]; other site
340322006200 chain length determination region; other site
340322006201 substrate-Mg2+ binding site; other site
340322006202 catalytic residues [active]
340322006203 aspartate-rich region 1; other site
340322006204 active site lid residues [active]
340322006205 aspartate-rich region 2; other site
340322006206 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
340322006207 Helix-turn-helix domain; Region: HTH_17; pfam12728
340322006208 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
340322006209 Catalytic domain of Protein Kinases; Region: PKc; cd00180
340322006210 active site
340322006211 ATP binding site [chemical binding]; other site
340322006212 substrate binding site [chemical binding]; other site
340322006213 activation loop (A-loop); other site
340322006214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
340322006215 PASTA domain; Region: PASTA; pfam03793
340322006216 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
340322006217 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
340322006218 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
340322006219 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
340322006220 Protein of unknown function (DUF2029); Region: DUF2029; cl09812
340322006221 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
340322006222 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
340322006223 Protein of unknown function (DUF2029); Region: DUF2029; cl09812
340322006224 Predicted esterase [General function prediction only]; Region: COG0627
340322006225 Predicted membrane protein [Function unknown]; Region: COG4763
340322006226 Acyltransferase family; Region: Acyl_transf_3; pfam01757
340322006227 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
340322006228 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
340322006229 putative acyl-acceptor binding pocket; other site
340322006230 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
340322006231 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
340322006232 nucleotide binding site [chemical binding]; other site
340322006233 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
340322006234 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
340322006235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
340322006236 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
340322006237 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
340322006238 NlpC/P60 family; Region: NLPC_P60; pfam00877
340322006239 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
340322006240 NlpC/P60 family; Region: NLPC_P60; pfam00877
340322006241 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
340322006242 heme bH binding site [chemical binding]; other site
340322006243 intrachain domain interface; other site
340322006244 heme bL binding site [chemical binding]; other site
340322006245 interchain domain interface [polypeptide binding]; other site
340322006246 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
340322006247 Qo binding site; other site
340322006248 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
340322006249 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
340322006250 iron-sulfur cluster [ion binding]; other site
340322006251 [2Fe-2S] cluster binding site [ion binding]; other site
340322006252 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
340322006253 Cytochrome c; Region: Cytochrom_C; pfam00034
340322006254 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
340322006255 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
340322006256 Subunit I/III interface [polypeptide binding]; other site
340322006257 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
340322006258 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
340322006259 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
340322006260 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
340322006261 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712
340322006262 active site
340322006263 dimer interface [polypeptide binding]; other site
340322006264 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991
340322006265 Ligand Binding Site [chemical binding]; other site
340322006266 Molecular Tunnel; other site
340322006267 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
340322006268 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
340322006269 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
340322006270 homotrimer interface [polypeptide binding]; other site
340322006271 Walker A motif; other site
340322006272 GTP binding site [chemical binding]; other site
340322006273 Walker B motif; other site
340322006274 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
340322006275 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
340322006276 putative dimer interface [polypeptide binding]; other site
340322006277 active site pocket [active]
340322006278 putative cataytic base [active]
340322006279 cobalamin synthase; Reviewed; Region: cobS; PRK00235
340322006280 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
340322006281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
340322006282 NAD(P) binding site [chemical binding]; other site
340322006283 active site
340322006284 Branched-chain amino acid aminotransferase; Region: DUF3665; pfam12427
340322006285 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
340322006286 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
340322006287 homodimer interface [polypeptide binding]; other site
340322006288 substrate-cofactor binding pocket; other site
340322006289 catalytic residue [active]
340322006290 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
340322006291 multifunctional aminopeptidase A; Provisional; Region: PRK00913
340322006292 interface (dimer of trimers) [polypeptide binding]; other site
340322006293 Substrate-binding/catalytic site; other site
340322006294 Zn-binding sites [ion binding]; other site
340322006295 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
340322006296 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
340322006297 E3 interaction surface; other site
340322006298 lipoyl attachment site [posttranslational modification]; other site
340322006299 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
340322006300 E3 interaction surface; other site
340322006301 lipoyl attachment site [posttranslational modification]; other site
340322006302 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
340322006303 E3 interaction surface; other site
340322006304 lipoyl attachment site [posttranslational modification]; other site
340322006305 e3 binding domain; Region: E3_binding; pfam02817
340322006306 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
340322006307 lipoate-protein ligase B; Provisional; Region: PRK14345
340322006308 lipoyl synthase; Provisional; Region: PRK05481
340322006309 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
340322006310 FeS/SAM binding site; other site
340322006311 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
340322006312 Predicted permease [General function prediction only]; Region: COG2985
340322006313 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
340322006314 TrkA-C domain; Region: TrkA_C; pfam02080
340322006315 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
340322006316 RDD family; Region: RDD; pfam06271
340322006317 glutamine synthetase, type I; Region: GlnA; TIGR00653
340322006318 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
340322006319 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
340322006320 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
340322006321 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
340322006322 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
340322006323 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
340322006324 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
340322006325 homotrimer interaction site [polypeptide binding]; other site
340322006326 putative active site [active]
340322006327 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
340322006328 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
340322006329 pyridoxal 5'-phosphate binding site [chemical binding]; other site
340322006330 catalytic residue [active]
340322006331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322006332 Major Facilitator Superfamily; Region: MFS_1; pfam07690
340322006333 putative substrate translocation pore; other site
340322006334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322006335 D-galactonate transporter; Region: 2A0114; TIGR00893
340322006336 putative substrate translocation pore; other site
340322006337 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
340322006338 heme binding pocket [chemical binding]; other site
340322006339 heme ligand [chemical binding]; other site
340322006340 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
340322006341 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
340322006342 metal binding triad; other site
340322006343 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
340322006344 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
340322006345 metal binding triad; other site
340322006346 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
340322006347 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
340322006348 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
340322006349 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
340322006350 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
340322006351 putative active site; other site
340322006352 putative metal binding residues [ion binding]; other site
340322006353 signature motif; other site
340322006354 putative triphosphate binding site [ion binding]; other site
340322006355 CHAD domain; Region: CHAD; pfam05235
340322006356 CHAD domain; Region: CHAD; pfam05235
340322006357 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
340322006358 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
340322006359 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
340322006360 RNB domain; Region: RNB; pfam00773
340322006361 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
340322006362 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
340322006363 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
340322006364 RNA/DNA hybrid binding site [nucleotide binding]; other site
340322006365 active site
340322006366 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
340322006367 catalytic core [active]
340322006368 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
340322006369 Putative zinc ribbon domain; Region: DUF164; pfam02591
340322006370 Uncharacterized conserved protein [Function unknown]; Region: COG0327
340322006371 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
340322006372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
340322006373 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
340322006374 Uncharacterized conserved protein [Function unknown]; Region: COG0327
340322006375 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
340322006376 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
340322006377 motif II; other site
340322006378 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
340322006379 Low molecular weight phosphatase family; Region: LMWPc; cd00115
340322006380 active site
340322006381 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
340322006382 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
340322006383 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
340322006384 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
340322006385 dimer interface [polypeptide binding]; other site
340322006386 TPP-binding site [chemical binding]; other site
340322006387 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
340322006388 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322006389 Walker A/P-loop; other site
340322006390 ATP binding site [chemical binding]; other site
340322006391 Q-loop/lid; other site
340322006392 ABC transporter signature motif; other site
340322006393 Walker B; other site
340322006394 D-loop; other site
340322006395 H-loop/switch region; other site
340322006396 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
340322006397 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
340322006398 TM-ABC transporter signature motif; other site
340322006399 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
340322006400 zinc binding site [ion binding]; other site
340322006401 putative ligand binding site [chemical binding]; other site
340322006402 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
340322006403 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
340322006404 Serine hydrolase; Region: Ser_hydrolase; cl17834
340322006405 acyl carrier protein; Provisional; Region: acpP; PRK00982
340322006406 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
340322006407 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
340322006408 active site
340322006409 motif I; other site
340322006410 motif II; other site
340322006411 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
340322006412 Uncharacterized conserved protein [Function unknown]; Region: COG4850
340322006413 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949
340322006414 Beta-lactamase; Region: Beta-lactamase; pfam00144
340322006415 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
340322006416 Domain of unknown function (DUF4274); Region: DUF4274; pfam14096
340322006417 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
340322006418 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
340322006419 putative active site [active]
340322006420 putative metal binding site [ion binding]; other site
340322006421 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
340322006422 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
340322006423 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
340322006424 DNA primase; Validated; Region: dnaG; PRK05667
340322006425 CHC2 zinc finger; Region: zf-CHC2; pfam01807
340322006426 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
340322006427 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
340322006428 active site
340322006429 metal binding site [ion binding]; metal-binding site
340322006430 interdomain interaction site; other site
340322006431 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
340322006432 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
340322006433 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607
340322006434 active site
340322006435 barstar interaction site; other site
340322006436 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
340322006437 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
340322006438 glutaminase active site [active]
340322006439 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
340322006440 dimer interface [polypeptide binding]; other site
340322006441 active site
340322006442 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
340322006443 dimer interface [polypeptide binding]; other site
340322006444 active site
340322006445 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
340322006446 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
340322006447 Zn2+ binding site [ion binding]; other site
340322006448 Mg2+ binding site [ion binding]; other site
340322006449 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
340322006450 Uncharacterized conserved protein [Function unknown]; Region: COG1434
340322006451 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
340322006452 putative active site [active]
340322006453 Repair protein; Region: Repair_PSII; pfam04536
340322006454 glycyl-tRNA synthetase; Provisional; Region: PRK04173
340322006455 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
340322006456 motif 1; other site
340322006457 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
340322006458 active site
340322006459 motif 2; other site
340322006460 motif 3; other site
340322006461 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
340322006462 anticodon binding site; other site
340322006463 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
340322006464 dimerization interface [polypeptide binding]; other site
340322006465 putative DNA binding site [nucleotide binding]; other site
340322006466 putative Zn2+ binding site [ion binding]; other site
340322006467 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
340322006468 metal binding site 2 [ion binding]; metal-binding site
340322006469 putative DNA binding helix; other site
340322006470 metal binding site 1 [ion binding]; metal-binding site
340322006471 dimer interface [polypeptide binding]; other site
340322006472 structural Zn2+ binding site [ion binding]; other site
340322006473 Domain of unknown function (DUF222); Region: DUF222; pfam02720
340322006474 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
340322006475 active site
340322006476 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
340322006477 diiron binding motif [ion binding]; other site
340322006478 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
340322006479 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
340322006480 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
340322006481 catalytic residue [active]
340322006482 putative FPP diphosphate binding site; other site
340322006483 putative FPP binding hydrophobic cleft; other site
340322006484 dimer interface [polypeptide binding]; other site
340322006485 putative IPP diphosphate binding site; other site
340322006486 Recombination protein O N terminal; Region: RecO_N; pfam11967
340322006487 DNA repair protein RecO; Reviewed; Region: recO; PRK00085
340322006488 Recombination protein O C terminal; Region: RecO_C; pfam02565
340322006489 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
340322006490 GTPase Era; Reviewed; Region: era; PRK00089
340322006491 G5 box; other site
340322006492 KH domain; Region: KH_2; pfam07650
340322006493 GTPase Era; Reviewed; Region: era; PRK00089
340322006494 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
340322006495 G1 box; other site
340322006496 GTP/Mg2+ binding site [chemical binding]; other site
340322006497 Switch I region; other site
340322006498 G2 box; other site
340322006499 Switch II region; other site
340322006500 G3 box; other site
340322006501 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
340322006502 Domain of unknown function DUF21; Region: DUF21; pfam01595
340322006503 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
340322006504 Transporter associated domain; Region: CorC_HlyC; smart01091
340322006505 metal-binding heat shock protein; Provisional; Region: PRK00016
340322006506 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
340322006507 PhoH-like protein; Region: PhoH; pfam02562
340322006508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
340322006509 RNA methyltransferase, RsmE family; Region: TIGR00046
340322006510 chaperone protein DnaJ; Provisional; Region: PRK14278
340322006511 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
340322006512 HSP70 interaction site [polypeptide binding]; other site
340322006513 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
340322006514 Zn binding sites [ion binding]; other site
340322006515 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
340322006516 dimer interface [polypeptide binding]; other site
340322006517 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
340322006518 coproporphyrinogen III oxidase; Validated; Region: PRK05628
340322006519 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
340322006520 FeS/SAM binding site; other site
340322006521 HemN C-terminal domain; Region: HemN_C; pfam06969
340322006522 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
340322006523 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
340322006524 acyl-activating enzyme (AAE) consensus motif; other site
340322006525 putative AMP binding site [chemical binding]; other site
340322006526 putative active site [active]
340322006527 putative CoA binding site [chemical binding]; other site
340322006528 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
340322006529 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
340322006530 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
340322006531 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
340322006532 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
340322006533 Walker A/P-loop; other site
340322006534 ATP binding site [chemical binding]; other site
340322006535 Q-loop/lid; other site
340322006536 ABC transporter signature motif; other site
340322006537 Walker B; other site
340322006538 D-loop; other site
340322006539 H-loop/switch region; other site
340322006540 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
340322006541 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
340322006542 active site
340322006543 Zn binding site [ion binding]; other site
340322006544 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
340322006545 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
340322006546 substrate binding pocket [chemical binding]; other site
340322006547 catalytic triad [active]
340322006548 trehalose synthase; Region: treS_nterm; TIGR02456
340322006549 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
340322006550 active site
340322006551 catalytic site [active]
340322006552 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
340322006553 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
340322006554 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
340322006555 active site
340322006556 metal binding site [ion binding]; metal-binding site
340322006557 nudix motif; other site
340322006558 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
340322006559 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
340322006560 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
340322006561 pyridoxal 5'-phosphate binding site [chemical binding]; other site
340322006562 homodimer interface [polypeptide binding]; other site
340322006563 catalytic residue [active]
340322006564 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
340322006565 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
340322006566 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
340322006567 choline/carnitine/betaine transport; Region: bcct; TIGR00842
340322006568 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231
340322006569 catalytic Zn binding site [ion binding]; other site
340322006570 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366
340322006571 structural Zn binding site [ion binding]; other site
340322006572 tetramer interface [polypeptide binding]; other site
340322006573 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351
340322006574 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
340322006575 motif II; other site
340322006576 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
340322006577 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
340322006578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322006579 dimer interface [polypeptide binding]; other site
340322006580 conserved gate region; other site
340322006581 ABC-ATPase subunit interface; other site
340322006582 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
340322006583 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
340322006584 Q-loop/lid; other site
340322006585 ABC transporter signature motif; other site
340322006586 Walker B; other site
340322006587 D-loop; other site
340322006588 H-loop/switch region; other site
340322006589 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
340322006590 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
340322006591 substrate binding pocket [chemical binding]; other site
340322006592 membrane-bound complex binding site; other site
340322006593 hinge residues; other site
340322006594 hydroxyglutarate oxidase; Provisional; Region: PRK11728
340322006595 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed
340322006596 Transcriptional regulators [Transcription]; Region: PhnF; COG2188
340322006597 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
340322006598 DNA-binding site [nucleotide binding]; DNA binding site
340322006599 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
340322006600 Predicted permeases [General function prediction only]; Region: COG0679
340322006601 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
340322006602 FAD binding domain; Region: FAD_binding_4; pfam01565
340322006603 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
340322006604 Transcriptional regulators [Transcription]; Region: GntR; COG1802
340322006605 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
340322006606 DNA-binding site [nucleotide binding]; DNA binding site
340322006607 FCD domain; Region: FCD; pfam07729
340322006608 DctM-like transporters; Region: DctM; pfam06808
340322006609 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
340322006610 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
340322006611 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
340322006612 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
340322006613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322006614 dimer interface [polypeptide binding]; other site
340322006615 conserved gate region; other site
340322006616 putative PBP binding loops; other site
340322006617 ABC-ATPase subunit interface; other site
340322006618 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
340322006619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322006620 dimer interface [polypeptide binding]; other site
340322006621 conserved gate region; other site
340322006622 putative PBP binding loops; other site
340322006623 ABC-ATPase subunit interface; other site
340322006624 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
340322006625 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
340322006626 Walker A/P-loop; other site
340322006627 ATP binding site [chemical binding]; other site
340322006628 Q-loop/lid; other site
340322006629 ABC transporter signature motif; other site
340322006630 Walker B; other site
340322006631 D-loop; other site
340322006632 H-loop/switch region; other site
340322006633 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
340322006634 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
340322006635 Walker A/P-loop; other site
340322006636 ATP binding site [chemical binding]; other site
340322006637 Q-loop/lid; other site
340322006638 ABC transporter signature motif; other site
340322006639 Walker B; other site
340322006640 D-loop; other site
340322006641 H-loop/switch region; other site
340322006642 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
340322006643 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
340322006644 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
340322006645 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
340322006646 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
340322006647 substrate binding site [chemical binding]; other site
340322006648 dimer interface [polypeptide binding]; other site
340322006649 ATP binding site [chemical binding]; other site
340322006650 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
340322006651 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
340322006652 bile acid transporter; Region: bass; TIGR00841
340322006653 Sodium Bile acid symporter family; Region: SBF; pfam01758
340322006654 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
340322006655 active site
340322006656 phosphate binding residues; other site
340322006657 catalytic residues [active]
340322006658 malate synthase G; Provisional; Region: PRK02999
340322006659 active site
340322006660 isocitrate lyase; Provisional; Region: PRK15063
340322006661 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
340322006662 tetramer interface [polypeptide binding]; other site
340322006663 active site
340322006664 Mg2+/Mn2+ binding site [ion binding]; other site
340322006665 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
340322006666 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
340322006667 putative active site [active]
340322006668 putative metal binding site [ion binding]; other site
340322006669 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
340322006670 Lamin Tail Domain; Region: LTD; pfam00932
340322006671 Esterase-like activity of phytase; Region: Phytase-like; pfam13449
340322006672 DctM-like transporters; Region: DctM; pfam06808
340322006673 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
340322006674 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
340322006675 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
340322006676 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
340322006677 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
340322006678 PemK-like protein; Region: PemK; pfam02452
340322006679 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
340322006680 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
340322006681 Ankyrin repeats (many copies); Region: Ank_4; pfam13637
340322006682 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
340322006683 Ankyrin repeats (many copies); Region: Ank_4; pfam13637
340322006684 hypothetical protein; Validated; Region: PRK05629
340322006685 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
340322006686 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
340322006687 Competence protein; Region: Competence; pfam03772
340322006688 SLBB domain; Region: SLBB; pfam10531
340322006689 Helix-hairpin-helix motif; Region: HHH_3; pfam12836
340322006690 Helix-hairpin-helix motif; Region: HHH; pfam00633
340322006691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
340322006692 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
340322006693 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
340322006694 catalytic core [active]
340322006695 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
340322006696 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
340322006697 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
340322006698 active site
340322006699 (T/H)XGH motif; other site
340322006700 Cutinase; Region: Cutinase; pfam01083
340322006701 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
340322006702 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
340322006703 putative catalytic cysteine [active]
340322006704 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159
340322006705 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
340322006706 putative ligand binding site [chemical binding]; other site
340322006707 putative NAD binding site [chemical binding]; other site
340322006708 catalytic site [active]
340322006709 glutamate 5-kinase; Region: proB; TIGR01027
340322006710 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
340322006711 nucleotide binding site [chemical binding]; other site
340322006712 homotetrameric interface [polypeptide binding]; other site
340322006713 putative phosphate binding site [ion binding]; other site
340322006714 putative allosteric binding site; other site
340322006715 PUA domain; Region: PUA; pfam01472
340322006716 GTPase CgtA; Reviewed; Region: obgE; PRK12296
340322006717 GTP1/OBG; Region: GTP1_OBG; pfam01018
340322006718 Obg GTPase; Region: Obg; cd01898
340322006719 G1 box; other site
340322006720 GTP/Mg2+ binding site [chemical binding]; other site
340322006721 Switch I region; other site
340322006722 G2 box; other site
340322006723 G3 box; other site
340322006724 Switch II region; other site
340322006725 G4 box; other site
340322006726 G5 box; other site
340322006727 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
340322006728 xanthine permease; Region: pbuX; TIGR03173
340322006729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195
340322006730 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
340322006731 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
340322006732 active site
340322006733 catalytic tetrad [active]
340322006734 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226
340322006735 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
340322006736 50S ribosomal protein L21; Validated; Region: rplU; PRK05573
340322006737 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
340322006738 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
340322006739 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
340322006740 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
340322006741 homodimer interface [polypeptide binding]; other site
340322006742 oligonucleotide binding site [chemical binding]; other site
340322006743 The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Region: 2A067; TIGR00921
340322006744 Pirin-related protein [General function prediction only]; Region: COG1741
340322006745 Pirin; Region: Pirin; pfam02678
340322006746 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
340322006747 Uncharacterized conserved protein [Function unknown]; Region: COG2128
340322006748 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
340322006749 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
340322006750 active site
340322006751 multimer interface [polypeptide binding]; other site
340322006752 Predicted acetyltransferase [General function prediction only]; Region: COG2388
340322006753 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
340322006754 hydrophobic ligand binding site; other site
340322006755 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
340322006756 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
340322006757 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
340322006758 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
340322006759 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
340322006760 active site
340322006761 HIGH motif; other site
340322006762 nucleotide binding site [chemical binding]; other site
340322006763 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
340322006764 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
340322006765 active site
340322006766 KMSKS motif; other site
340322006767 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
340322006768 tRNA binding surface [nucleotide binding]; other site
340322006769 anticodon binding site; other site
340322006770 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
340322006771 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
340322006772 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
340322006773 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
340322006774 Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077
340322006775 nucleotide binding site [chemical binding]; other site
340322006776 putative NEF/HSP70 interaction site [polypeptide binding]; other site
340322006777 SBD interface [polypeptide binding]; other site
340322006778 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
340322006779 malate dehydrogenase; Provisional; Region: PRK05442
340322006780 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
340322006781 NAD(P) binding site [chemical binding]; other site
340322006782 dimer interface [polypeptide binding]; other site
340322006783 malate binding site [chemical binding]; other site
340322006784 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
340322006785 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
340322006786 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
340322006787 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
340322006788 iron-sulfur cluster [ion binding]; other site
340322006789 [2Fe-2S] cluster binding site [ion binding]; other site
340322006790 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
340322006791 alpha subunit interface [polypeptide binding]; other site
340322006792 active site
340322006793 substrate binding site [chemical binding]; other site
340322006794 Fe binding site [ion binding]; other site
340322006795 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
340322006796 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
340322006797 FMN-binding pocket [chemical binding]; other site
340322006798 flavin binding motif; other site
340322006799 phosphate binding motif [ion binding]; other site
340322006800 beta-alpha-beta structure motif; other site
340322006801 NAD binding pocket [chemical binding]; other site
340322006802 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
340322006803 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
340322006804 catalytic loop [active]
340322006805 iron binding site [ion binding]; other site
340322006806 benzoate transport; Region: 2A0115; TIGR00895
340322006807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322006808 putative substrate translocation pore; other site
340322006809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322006810 Predicted permeases [General function prediction only]; Region: COG0679
340322006811 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
340322006812 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994
340322006813 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
340322006814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340322006815 Walker A motif; other site
340322006816 ATP binding site [chemical binding]; other site
340322006817 Walker B motif; other site
340322006818 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
340322006819 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844
340322006820 active site
340322006821 catalytic triad [active]
340322006822 oxyanion hole [active]
340322006823 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
340322006824 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
340322006825 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
340322006826 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
340322006827 Bacterial transcriptional regulator; Region: IclR; pfam01614
340322006828 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
340322006829 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
340322006830 dimer interface [polypeptide binding]; other site
340322006831 active site
340322006832 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
340322006833 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
340322006834 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
340322006835 DNA binding residues [nucleotide binding]
340322006836 dimerization interface [polypeptide binding]; other site
340322006837 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
340322006838 3-carboxy-cis,cis-muconate cycloisomerase; Region: protocat_pcaB; TIGR02426
340322006839 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
340322006840 tetramer interface [polypeptide binding]; other site
340322006841 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
340322006842 protocatechuate 3,4-dioxygenase, alpha subunit; Region: protocat_alph; TIGR02423
340322006843 active site
340322006844 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
340322006845 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
340322006846 active site
340322006847 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
340322006848 active site
340322006849 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829
340322006850 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
340322006851 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
340322006852 metal binding site [ion binding]; metal-binding site
340322006853 substrate binding pocket [chemical binding]; other site
340322006854 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438
340322006855 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
340322006856 active site
340322006857 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
340322006858 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
340322006859 iron-sulfur cluster [ion binding]; other site
340322006860 [2Fe-2S] cluster binding site [ion binding]; other site
340322006861 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
340322006862 putative alpha subunit interface [polypeptide binding]; other site
340322006863 putative active site [active]
340322006864 putative substrate binding site [chemical binding]; other site
340322006865 Fe binding site [ion binding]; other site
340322006866 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
340322006867 inter-subunit interface; other site
340322006868 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
340322006869 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
340322006870 catalytic loop [active]
340322006871 iron binding site [ion binding]; other site
340322006872 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
340322006873 FAD binding pocket [chemical binding]; other site
340322006874 FAD binding motif [chemical binding]; other site
340322006875 phosphate binding motif [ion binding]; other site
340322006876 beta-alpha-beta structure motif; other site
340322006877 NAD binding pocket [chemical binding]; other site
340322006878 Transcriptional regulators [Transcription]; Region: FadR; COG2186
340322006879 FCD domain; Region: FCD; pfam07729
340322006880 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
340322006881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
340322006882 NAD(P) binding site [chemical binding]; other site
340322006883 active site
340322006884 AAA ATPase domain; Region: AAA_16; pfam13191
340322006885 AAA domain; Region: AAA_22; pfam13401
340322006886 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
340322006887 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
340322006888 DNA binding residues [nucleotide binding]
340322006889 dimerization interface [polypeptide binding]; other site
340322006890 benzoate transport; Region: 2A0115; TIGR00895
340322006891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322006892 putative substrate translocation pore; other site
340322006893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322006894 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
340322006895 benzoate transporter; Region: benE; TIGR00843
340322006896 PAS domain; Region: PAS; smart00091
340322006897 PAS domain; Region: PAS_9; pfam13426
340322006898 putative active site [active]
340322006899 heme pocket [chemical binding]; other site
340322006900 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
340322006901 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
340322006902 dimer interface [polypeptide binding]; other site
340322006903 phosphorylation site [posttranslational modification]
340322006904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
340322006905 ATP binding site [chemical binding]; other site
340322006906 Mg2+ binding site [ion binding]; other site
340322006907 G-X-G motif; other site
340322006908 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
340322006909 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
340322006910 active site
340322006911 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
340322006912 [2Fe-2S] cluster binding site [ion binding]; other site
340322006913 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
340322006914 putative alpha subunit interface [polypeptide binding]; other site
340322006915 putative active site [active]
340322006916 putative substrate binding site [chemical binding]; other site
340322006917 Fe binding site [ion binding]; other site
340322006918 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
340322006919 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
340322006920 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
340322006921 NAD(P) binding site [chemical binding]; other site
340322006922 active site
340322006923 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
340322006924 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
340322006925 FMN-binding pocket [chemical binding]; other site
340322006926 flavin binding motif; other site
340322006927 phosphate binding motif [ion binding]; other site
340322006928 beta-alpha-beta structure motif; other site
340322006929 NAD binding pocket [chemical binding]; other site
340322006930 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
340322006931 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
340322006932 catalytic loop [active]
340322006933 iron binding site [ion binding]; other site
340322006934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
340322006935 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
340322006936 active site
340322006937 phosphorylation site [posttranslational modification]
340322006938 intermolecular recognition site; other site
340322006939 dimerization interface [polypeptide binding]; other site
340322006940 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
340322006941 DNA binding residues [nucleotide binding]
340322006942 dimerization interface [polypeptide binding]; other site
340322006943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322006944 putative substrate translocation pore; other site
340322006945 Major Facilitator Superfamily; Region: MFS_1; pfam07690
340322006946 Flavin reductase like domain; Region: Flavin_Reduct; smart00903
340322006947 SnoaL-like domain; Region: SnoaL_4; pfam13577
340322006948 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
340322006949 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
340322006950 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
340322006951 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
340322006952 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
340322006953 oligomer interface [polypeptide binding]; other site
340322006954 active site residues [active]
340322006955 Clp protease; Region: CLP_protease; pfam00574
340322006956 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
340322006957 oligomer interface [polypeptide binding]; other site
340322006958 active site residues [active]
340322006959 trigger factor; Provisional; Region: tig; PRK01490
340322006960 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
340322006961 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
340322006962 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
340322006963 dimerization interface [polypeptide binding]; other site
340322006964 putative DNA binding site [nucleotide binding]; other site
340322006965 putative Zn2+ binding site [ion binding]; other site
340322006966 Beta-lactamase; Region: Beta-lactamase; pfam00144
340322006967 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
340322006968 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
340322006969 MULE transposase domain; Region: MULE; pfam10551
340322006970 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
340322006971 Protein of unknown function (DUF418); Region: DUF418; pfam04235
340322006972 DSBA-like thioredoxin domain; Region: DSBA; pfam01323
340322006973 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
340322006974 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
340322006975 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
340322006976 Zn binding site [ion binding]; other site
340322006977 HTH-like domain; Region: HTH_21; pfam13276
340322006978 Integrase core domain; Region: rve; pfam00665
340322006979 Integrase core domain; Region: rve_3; pfam13683
340322006980 Transposase; Region: HTH_Tnp_1; cl17663
340322006981 Transcriptional regulator [Transcription]; Region: IclR; COG1414
340322006982 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
340322006983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322006984 metabolite-proton symporter; Region: 2A0106; TIGR00883
340322006985 putative substrate translocation pore; other site
340322006986 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
340322006987 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
340322006988 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
340322006989 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
340322006990 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
340322006991 catalytic Zn binding site [ion binding]; other site
340322006992 NAD binding site [chemical binding]; other site
340322006993 structural Zn binding site [ion binding]; other site
340322006994 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151
340322006995 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
340322006996 NAD(P) binding site [chemical binding]; other site
340322006997 catalytic residues [active]
340322006998 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337
340322006999 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745
340322007000 putative NAD(P) binding site [chemical binding]; other site
340322007001 active site
340322007002 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
340322007003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
340322007004 NAD(P) binding site [chemical binding]; other site
340322007005 active site
340322007006 Putative cyclase; Region: Cyclase; pfam04199
340322007007 phytoene desaturase; Region: crtI_fam; TIGR02734
340322007008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322007009 Major Facilitator Superfamily; Region: MFS_1; pfam07690
340322007010 putative substrate translocation pore; other site
340322007011 CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029
340322007012 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030
340322007013 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
340322007014 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
340322007015 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
340322007016 Walker A/P-loop; other site
340322007017 ATP binding site [chemical binding]; other site
340322007018 Q-loop/lid; other site
340322007019 ABC transporter signature motif; other site
340322007020 Walker B; other site
340322007021 D-loop; other site
340322007022 H-loop/switch region; other site
340322007023 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
340322007024 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
340322007025 Walker A/P-loop; other site
340322007026 ATP binding site [chemical binding]; other site
340322007027 Q-loop/lid; other site
340322007028 ABC transporter signature motif; other site
340322007029 Walker B; other site
340322007030 D-loop; other site
340322007031 H-loop/switch region; other site
340322007032 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
340322007033 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
340322007034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322007035 putative PBP binding loops; other site
340322007036 dimer interface [polypeptide binding]; other site
340322007037 ABC-ATPase subunit interface; other site
340322007038 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
340322007039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322007040 dimer interface [polypeptide binding]; other site
340322007041 conserved gate region; other site
340322007042 putative PBP binding loops; other site
340322007043 ABC-ATPase subunit interface; other site
340322007044 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
340322007045 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
340322007046 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
340322007047 hypothetical protein; Provisional; Region: PRK06062
340322007048 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
340322007049 inhibitor-cofactor binding pocket; inhibition site
340322007050 pyridoxal 5'-phosphate binding site [chemical binding]; other site
340322007051 catalytic residue [active]
340322007052 Domain of unknown function (DUF222); Region: DUF222; pfam02720
340322007053 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
340322007054 active site
340322007055 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
340322007056 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
340322007057 short chain dehydrogenase; Provisional; Region: PRK08219
340322007058 HetN oxidoreductase-like, classical (c) SDR; Region: HetN_like_SDR_c; cd08932
340322007059 putative NAD(P) binding site [chemical binding]; other site
340322007060 active site
340322007061 tetracycline repressor protein TetR; Provisional; Region: PRK13756
340322007062 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
340322007063 cystathionine gamma-synthase; Provisional; Region: PRK07811
340322007064 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
340322007065 homodimer interface [polypeptide binding]; other site
340322007066 substrate-cofactor binding pocket; other site
340322007067 pyridoxal 5'-phosphate binding site [chemical binding]; other site
340322007068 catalytic residue [active]
340322007069 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
340322007070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322007071 Walker A/P-loop; other site
340322007072 ATP binding site [chemical binding]; other site
340322007073 Q-loop/lid; other site
340322007074 ABC transporter signature motif; other site
340322007075 Walker B; other site
340322007076 D-loop; other site
340322007077 H-loop/switch region; other site
340322007078 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
340322007079 Mechanosensitive ion channel; Region: MS_channel; pfam00924
340322007080 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
340322007081 apolar tunnel; other site
340322007082 heme binding site [chemical binding]; other site
340322007083 dimerization interface [polypeptide binding]; other site
340322007084 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
340322007085 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
340322007086 Chromate transporter; Region: Chromate_transp; pfam02417
340322007087 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
340322007088 active site
340322007089 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
340322007090 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
340322007091 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
340322007092 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322007093 Walker A/P-loop; other site
340322007094 ATP binding site [chemical binding]; other site
340322007095 Q-loop/lid; other site
340322007096 ABC transporter signature motif; other site
340322007097 Walker B; other site
340322007098 D-loop; other site
340322007099 H-loop/switch region; other site
340322007100 ABC transporter; Region: ABC_tran_2; pfam12848
340322007101 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
340322007102 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
340322007103 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
340322007104 dimer interface [polypeptide binding]; other site
340322007105 ssDNA binding site [nucleotide binding]; other site
340322007106 tetramer (dimer of dimers) interface [polypeptide binding]; other site
340322007107 Copper resistance protein D; Region: CopD; pfam05425
340322007108 Predicted membrane protein [Function unknown]; Region: COG3336
340322007109 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
340322007110 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
340322007111 active site
340322007112 dimer interface [polypeptide binding]; other site
340322007113 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
340322007114 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
340322007115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322007116 dimer interface [polypeptide binding]; other site
340322007117 conserved gate region; other site
340322007118 putative PBP binding loops; other site
340322007119 ABC-ATPase subunit interface; other site
340322007120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322007121 dimer interface [polypeptide binding]; other site
340322007122 conserved gate region; other site
340322007123 putative PBP binding loops; other site
340322007124 ABC-ATPase subunit interface; other site
340322007125 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
340322007126 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
340322007127 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
340322007128 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
340322007129 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
340322007130 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
340322007131 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
340322007132 Walker A/P-loop; other site
340322007133 ATP binding site [chemical binding]; other site
340322007134 Q-loop/lid; other site
340322007135 ABC transporter signature motif; other site
340322007136 Walker B; other site
340322007137 D-loop; other site
340322007138 H-loop/switch region; other site
340322007139 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
340322007140 catalytic residues [active]
340322007141 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
340322007142 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
340322007143 catalytic Zn binding site [ion binding]; other site
340322007144 NAD binding site [chemical binding]; other site
340322007145 structural Zn binding site [ion binding]; other site
340322007146 Isochorismatase family; Region: Isochorismatase; pfam00857
340322007147 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
340322007148 catalytic triad [active]
340322007149 conserved cis-peptide bond; other site
340322007150 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
340322007151 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
340322007152 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
340322007153 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
340322007154 CGNR zinc finger; Region: zf-CGNR; pfam11706
340322007155 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861
340322007156 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
340322007157 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990
340322007158 Ligand Binding Site [chemical binding]; other site
340322007159 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
340322007160 AIR carboxylase; Region: AIRC; smart01001
340322007161 Uncharacterized conserved protein [Function unknown]; Region: COG1641
340322007162 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
340322007163 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
340322007164 classical (c) SDRs; Region: SDR_c; cd05233
340322007165 NAD(P) binding site [chemical binding]; other site
340322007166 active site
340322007167 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
340322007168 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
340322007169 catalytic site [active]
340322007170 putative active site [active]
340322007171 putative substrate binding site [chemical binding]; other site
340322007172 dimer interface [polypeptide binding]; other site
340322007173 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
340322007174 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
340322007175 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
340322007176 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
340322007177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
340322007178 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
340322007179 Ankyrin repeats (many copies); Region: Ank_4; pfam13637
340322007180 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
340322007181 BCCT family transporter; Region: BCCT; cl00569
340322007182 SdpI/YhfL protein family; Region: SdpI; pfam13630
340322007183 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
340322007184 glutaminase; Provisional; Region: PRK00971
340322007185 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
340322007186 Transcriptional regulators [Transcription]; Region: PurR; COG1609
340322007187 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
340322007188 DNA binding site [nucleotide binding]
340322007189 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
340322007190 dimerization interface [polypeptide binding]; other site
340322007191 ligand binding site [chemical binding]; other site
340322007192 Transcriptional regulators [Transcription]; Region: PurR; COG1609
340322007193 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
340322007194 DNA binding site [nucleotide binding]
340322007195 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
340322007196 dimerization interface [polypeptide binding]; other site
340322007197 ligand binding site [chemical binding]; other site
340322007198 glucuronate isomerase; Reviewed; Region: PRK02925
340322007199 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
340322007200 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
340322007201 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
340322007202 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
340322007203 glucuronide transporter; Provisional; Region: PRK09848
340322007204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322007205 putative substrate translocation pore; other site
340322007206 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
340322007207 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
340322007208 ATP-binding site [chemical binding]; other site
340322007209 Gluconate-6-phosphate binding site [chemical binding]; other site
340322007210 Shikimate kinase; Region: SKI; pfam01202
340322007211 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
340322007212 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
340322007213 active site
340322007214 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
340322007215 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
340322007216 active site
340322007217 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
340322007218 Isochorismatase family; Region: Isochorismatase; pfam00857
340322007219 catalytic triad [active]
340322007220 metal binding site [ion binding]; metal-binding site
340322007221 conserved cis-peptide bond; other site
340322007222 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
340322007223 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
340322007224 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
340322007225 catalytic triad [active]
340322007226 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
340322007227 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
340322007228 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
340322007229 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
340322007230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322007231 putative substrate translocation pore; other site
340322007232 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
340322007233 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
340322007234 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
340322007235 phosphate binding site [ion binding]; other site
340322007236 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
340322007237 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
340322007238 active site 2 [active]
340322007239 active site 1 [active]
340322007240 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
340322007241 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
340322007242 3-oxoacyl-[acyl-carrier protein]; Region: COG4982
340322007243 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
340322007244 putative NAD(P) binding site [chemical binding]; other site
340322007245 active site
340322007246 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
340322007247 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
340322007248 active site
340322007249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
340322007250 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
340322007251 NAD(P) binding site [chemical binding]; other site
340322007252 active site
340322007253 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
340322007254 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
340322007255 Glucitol operon activator [Transcription]; Region: GutM; COG4578
340322007256 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
340322007257 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
340322007258 active site
340322007259 dimerization interface [polypeptide binding]; other site
340322007260 ribonuclease PH; Reviewed; Region: rph; PRK00173
340322007261 Ribonuclease PH; Region: RNase_PH_bact; cd11362
340322007262 hexamer interface [polypeptide binding]; other site
340322007263 active site
340322007264 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
340322007265 glutamate racemase; Provisional; Region: PRK00865
340322007266 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
340322007267 MarR family; Region: MarR; pfam01047
340322007268 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
340322007269 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
340322007270 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
340322007271 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
340322007272 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
340322007273 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
340322007274 active site
340322007275 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
340322007276 DEAD/DEAH box helicase; Region: DEAD; pfam00270
340322007277 DEAD_2; Region: DEAD_2; pfam06733
340322007278 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
340322007279 Peptidyl-tRNA hydrolase [Translation, ribosomal structure and biogenesis]; Region: pth2; COG1990
340322007280 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
340322007281 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
340322007282 D-pathway; other site
340322007283 Putative ubiquinol binding site [chemical binding]; other site
340322007284 Low-spin heme (heme b) binding site [chemical binding]; other site
340322007285 Putative water exit pathway; other site
340322007286 Binuclear center (heme o3/CuB) [ion binding]; other site
340322007287 K-pathway; other site
340322007288 Putative proton exit pathway; other site
340322007289 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
340322007290 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
340322007291 dimer interface [polypeptide binding]; other site
340322007292 putative radical transfer pathway; other site
340322007293 diiron center [ion binding]; other site
340322007294 tyrosyl radical; other site
340322007295 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
340322007296 Ferritin-like domain; Region: Ferritin; pfam00210
340322007297 ferroxidase diiron center [ion binding]; other site
340322007298 Transcriptional regulators [Transcription]; Region: FadR; COG2186
340322007299 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
340322007300 DNA-binding site [nucleotide binding]; DNA binding site
340322007301 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
340322007302 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
340322007303 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
340322007304 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
340322007305 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
340322007306 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
340322007307 Protein of unknown function (DUF2895); Region: DUF2895; cl12968
340322007308 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
340322007309 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
340322007310 Class I ribonucleotide reductase; Region: RNR_I; cd01679
340322007311 active site
340322007312 dimer interface [polypeptide binding]; other site
340322007313 catalytic residues [active]
340322007314 effector binding site; other site
340322007315 R2 peptide binding site; other site
340322007316 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
340322007317 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
340322007318 catalytic residues [active]
340322007319 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
340322007320 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
340322007321 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
340322007322 homodimer interface [polypeptide binding]; other site
340322007323 NAD binding pocket [chemical binding]; other site
340322007324 ATP binding pocket [chemical binding]; other site
340322007325 Mg binding site [ion binding]; other site
340322007326 active-site loop [active]
340322007327 Fructosamine kinase; Region: Fructosamin_kin; cl17579
340322007328 Phosphotransferase enzyme family; Region: APH; pfam01636
340322007329 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
340322007330 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
340322007331 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
340322007332 NADP binding site [chemical binding]; other site
340322007333 dimer interface [polypeptide binding]; other site
340322007334 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
340322007335 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
340322007336 catalytic residues [active]
340322007337 phosphoglucomutase; Validated; Region: PRK07564
340322007338 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
340322007339 active site
340322007340 substrate binding site [chemical binding]; other site
340322007341 metal binding site [ion binding]; metal-binding site
340322007342 camphor resistance protein CrcB; Provisional; Region: ccrB; PRK00134
340322007343 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
340322007344 hypothetical protein; Provisional; Region: PRK05463
340322007345 Predicted membrane protein [General function prediction only]; Region: COG4194
340322007346 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
340322007347 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
340322007348 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
340322007349 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
340322007350 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
340322007351 FtsX-like permease family; Region: FtsX; pfam02687
340322007352 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
340322007353 FtsX-like permease family; Region: FtsX; pfam02687
340322007354 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
340322007355 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
340322007356 Walker A/P-loop; other site
340322007357 ATP binding site [chemical binding]; other site
340322007358 Q-loop/lid; other site
340322007359 ABC transporter signature motif; other site
340322007360 Walker B; other site
340322007361 D-loop; other site
340322007362 H-loop/switch region; other site
340322007363 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
340322007364 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
340322007365 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
340322007366 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
340322007367 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
340322007368 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
340322007369 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
340322007370 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
340322007371 MFS/sugar transport protein; Region: MFS_2; pfam13347
340322007372 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
340322007373 Methyltransferase domain; Region: Methyltransf_23; pfam13489
340322007374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
340322007375 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
340322007376 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
340322007377 hinge; other site
340322007378 active site
340322007379 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096
340322007380 GAF domain; Region: GAF_2; pfam13185
340322007381 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
340322007382 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
340322007383 DNA binding residues [nucleotide binding]
340322007384 dimerization interface [polypeptide binding]; other site
340322007385 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
340322007386 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
340322007387 dimer interface [polypeptide binding]; other site
340322007388 pyridoxal 5'-phosphate binding site [chemical binding]; other site
340322007389 catalytic residue [active]
340322007390 serine O-acetyltransferase; Region: cysE; TIGR01172
340322007391 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
340322007392 trimer interface [polypeptide binding]; other site
340322007393 active site
340322007394 substrate binding site [chemical binding]; other site
340322007395 CoA binding site [chemical binding]; other site
340322007396 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
340322007397 Coenzyme A binding pocket [chemical binding]; other site
340322007398 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
340322007399 CoA binding domain; Region: CoA_binding; smart00881
340322007400 CoA-ligase; Region: Ligase_CoA; pfam00549
340322007401 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
340322007402 ATP-grasp domain; Region: ATP-grasp_2; pfam08442
340322007403 CoA-ligase; Region: Ligase_CoA; pfam00549
340322007404 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
340322007405 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
340322007406 catalytic residues [active]
340322007407 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
340322007408 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
340322007409 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
340322007410 succinate CoA transferase; Region: YgfH_subfam; TIGR03458
340322007411 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
340322007412 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
340322007413 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
340322007414 FMN binding site [chemical binding]; other site
340322007415 active site
340322007416 catalytic residues [active]
340322007417 substrate binding site [chemical binding]; other site
340322007418 Phosphate uptake regulator [Inorganic ion transport and metabolism]; Region: PhoU; COG0704
340322007419 PhoU domain; Region: PhoU; pfam01895
340322007420 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
340322007421 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
340322007422 Walker A/P-loop; other site
340322007423 ATP binding site [chemical binding]; other site
340322007424 Q-loop/lid; other site
340322007425 ABC transporter signature motif; other site
340322007426 Walker B; other site
340322007427 D-loop; other site
340322007428 H-loop/switch region; other site
340322007429 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
340322007430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322007431 dimer interface [polypeptide binding]; other site
340322007432 conserved gate region; other site
340322007433 putative PBP binding loops; other site
340322007434 ABC-ATPase subunit interface; other site
340322007435 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
340322007436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322007437 dimer interface [polypeptide binding]; other site
340322007438 conserved gate region; other site
340322007439 putative PBP binding loops; other site
340322007440 ABC-ATPase subunit interface; other site
340322007441 PBP superfamily domain; Region: PBP_like_2; cl17296
340322007442 mycothiol synthase; Region: mycothiol_MshD; TIGR03448
340322007443 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
340322007444 Coenzyme A binding pocket [chemical binding]; other site
340322007445 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
340322007446 Coenzyme A binding pocket [chemical binding]; other site
340322007447 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
340322007448 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
340322007449 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
340322007450 nitrobindin heme-binding domain; Region: nitrobindin; cd07828
340322007451 heme-binding site [chemical binding]; other site
340322007452 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
340322007453 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
340322007454 pyridoxal 5'-phosphate binding site [chemical binding]; other site
340322007455 catalytic residue [active]
340322007456 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
340322007457 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
340322007458 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
340322007459 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
340322007460 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
340322007461 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
340322007462 dimerization interface [polypeptide binding]; other site
340322007463 putative ATP binding site [chemical binding]; other site
340322007464 amidophosphoribosyltransferase; Provisional; Region: PRK07847
340322007465 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
340322007466 active site
340322007467 tetramer interface [polypeptide binding]; other site
340322007468 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
340322007469 active site
340322007470 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
340322007471 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
340322007472 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
340322007473 channel protein, hemolysin III family; Region: hlyIII; TIGR01065
340322007474 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
340322007475 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
340322007476 dimerization interface [polypeptide binding]; other site
340322007477 ATP binding site [chemical binding]; other site
340322007478 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
340322007479 dimerization interface [polypeptide binding]; other site
340322007480 ATP binding site [chemical binding]; other site
340322007481 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
340322007482 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
340322007483 putative active site [active]
340322007484 catalytic triad [active]
340322007485 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
340322007486 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
340322007487 catalytic residues [active]
340322007488 dimer interface [polypeptide binding]; other site
340322007489 Predicted extracellular nuclease [General function prediction only]; Region: COG2374
340322007490 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
340322007491 generic binding surface II; other site
340322007492 generic binding surface I; other site
340322007493 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
340322007494 putative active site [active]
340322007495 putative catalytic site [active]
340322007496 putative Mg binding site IVb [ion binding]; other site
340322007497 putative phosphate binding site [ion binding]; other site
340322007498 putative DNA binding site [nucleotide binding]; other site
340322007499 putative Mg binding site IVa [ion binding]; other site
340322007500 Predicted deacetylase [General function prediction only]; Region: COG3233
340322007501 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
340322007502 putative active site [active]
340322007503 putative Zn binding site [ion binding]; other site
340322007504 Sodium:dicarboxylate symporter family; Region: SDF; cl00573
340322007505 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
340322007506 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
340322007507 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
340322007508 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
340322007509 ATP binding site [chemical binding]; other site
340322007510 active site
340322007511 substrate binding site [chemical binding]; other site
340322007512 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
340322007513 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
340322007514 tetramer interface [polypeptide binding]; other site
340322007515 aspartate aminotransferase; Provisional; Region: PRK05764
340322007516 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
340322007517 pyridoxal 5'-phosphate binding site [chemical binding]; other site
340322007518 homodimer interface [polypeptide binding]; other site
340322007519 catalytic residue [active]
340322007520 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
340322007521 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
340322007522 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
340322007523 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
340322007524 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
340322007525 nucleotide binding site/active site [active]
340322007526 HIT family signature motif; other site
340322007527 catalytic residue [active]
340322007528 Methyltransferase domain; Region: Methyltransf_31; pfam13847
340322007529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340322007530 S-adenosylmethionine binding site [chemical binding]; other site
340322007531 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
340322007532 POT family; Region: PTR2; cl17359
340322007533 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630
340322007534 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
340322007535 inhibitor-cofactor binding pocket; inhibition site
340322007536 pyridoxal 5'-phosphate binding site [chemical binding]; other site
340322007537 catalytic residue [active]
340322007538 AAA domain; Region: AAA_26; pfam13500
340322007539 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
340322007540 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109
340322007541 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
340322007542 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
340322007543 dimerization interface [polypeptide binding]; other site
340322007544 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
340322007545 dimer interface [polypeptide binding]; other site
340322007546 phosphorylation site [posttranslational modification]
340322007547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
340322007548 ATP binding site [chemical binding]; other site
340322007549 Mg2+ binding site [ion binding]; other site
340322007550 G-X-G motif; other site
340322007551 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
340322007552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
340322007553 active site
340322007554 phosphorylation site [posttranslational modification]
340322007555 intermolecular recognition site; other site
340322007556 dimerization interface [polypeptide binding]; other site
340322007557 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
340322007558 DNA binding site [nucleotide binding]
340322007559 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
340322007560 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
340322007561 DNA binding residues [nucleotide binding]
340322007562 dimer interface [polypeptide binding]; other site
340322007563 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
340322007564 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
340322007565 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820
340322007566 dimer interface [polypeptide binding]; other site
340322007567 active site
340322007568 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
340322007569 substrate binding site [chemical binding]; other site
340322007570 catalytic residue [active]
340322007571 pyruvate dehydrogenase; Provisional; Region: PRK06546
340322007572 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
340322007573 PYR/PP interface [polypeptide binding]; other site
340322007574 dimer interface [polypeptide binding]; other site
340322007575 tetramer interface [polypeptide binding]; other site
340322007576 TPP binding site [chemical binding]; other site
340322007577 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
340322007578 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
340322007579 TPP-binding site [chemical binding]; other site
340322007580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322007581 Major Facilitator Superfamily; Region: MFS_1; pfam07690
340322007582 putative substrate translocation pore; other site
340322007583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322007584 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
340322007585 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
340322007586 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
340322007587 Ion channel regulatory protein UNC-93; Region: UNC-93; pfam05978
340322007588 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
340322007589 active site
340322007590 catalytic residues [active]
340322007591 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
340322007592 active site
340322007593 catalytic residues [active]
340322007594 putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134
340322007595 putative succinate dehydrogenase; Reviewed; Region: PRK12842
340322007596 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
340322007597 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
340322007598 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
340322007599 NAD(P) binding site [chemical binding]; other site
340322007600 YCII-related domain; Region: YCII; cl00999
340322007601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322007602 metabolite-proton symporter; Region: 2A0106; TIGR00883
340322007603 putative substrate translocation pore; other site
340322007604 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
340322007605 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
340322007606 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
340322007607 dimerization interface [polypeptide binding]; other site
340322007608 substrate binding pocket [chemical binding]; other site
340322007609 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921
340322007610 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl17742
340322007611 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
340322007612 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
340322007613 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
340322007614 active site
340322007615 motif I; other site
340322007616 motif II; other site
340322007617 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
340322007618 Uncharacterized conserved protein [Function unknown]; Region: COG5646
340322007619 Uncharacterized conserved protein [Function unknown]; Region: COG2966
340322007620 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
340322007621 Uncharacterized conserved protein [Function unknown]; Region: COG3610
340322007622 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
340322007623 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
340322007624 active site
340322007625 homotetramer interface [polypeptide binding]; other site
340322007626 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
340322007627 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
340322007628 Transcriptional regulators [Transcription]; Region: PurR; COG1609
340322007629 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
340322007630 DNA binding site [nucleotide binding]
340322007631 domain linker motif; other site
340322007632 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
340322007633 putative dimerization interface [polypeptide binding]; other site
340322007634 putative ligand binding site [chemical binding]; other site
340322007635 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
340322007636 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
340322007637 intersubunit interface [polypeptide binding]; other site
340322007638 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
340322007639 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322007640 Walker A/P-loop; other site
340322007641 ATP binding site [chemical binding]; other site
340322007642 Q-loop/lid; other site
340322007643 ABC transporter signature motif; other site
340322007644 Walker B; other site
340322007645 D-loop; other site
340322007646 H-loop/switch region; other site
340322007647 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
340322007648 dimer interface [polypeptide binding]; other site
340322007649 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
340322007650 putative PBP binding regions; other site
340322007651 ABC-ATPase subunit interface; other site
340322007652 hypothetical protein; Provisional; Region: PRK12839
340322007653 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
340322007654 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
340322007655 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
340322007656 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
340322007657 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
340322007658 metabolite-proton symporter; Region: 2A0106; TIGR00883
340322007659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322007660 putative substrate translocation pore; other site
340322007661 Transcriptional regulator [Transcription]; Region: IclR; COG1414
340322007662 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
340322007663 Bacterial transcriptional regulator; Region: IclR; pfam01614
340322007664 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
340322007665 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
340322007666 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
340322007667 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
340322007668 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
340322007669 active site
340322007670 HIGH motif; other site
340322007671 nucleotide binding site [chemical binding]; other site
340322007672 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
340322007673 KMSKS motif; other site
340322007674 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
340322007675 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
340322007676 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
340322007677 active site turn [active]
340322007678 phosphorylation site [posttranslational modification]
340322007679 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
340322007680 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
340322007681 HPr interaction site; other site
340322007682 glycerol kinase (GK) interaction site [polypeptide binding]; other site
340322007683 active site
340322007684 phosphorylation site [posttranslational modification]
340322007685 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251
340322007686 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
340322007687 substrate binding [chemical binding]; other site
340322007688 active site
340322007689 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
340322007690 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
340322007691 active site
340322007692 trimer interface [polypeptide binding]; other site
340322007693 allosteric site; other site
340322007694 active site lid [active]
340322007695 hexamer (dimer of trimers) interface [polypeptide binding]; other site
340322007696 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
340322007697 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
340322007698 active site
340322007699 dimer interface [polypeptide binding]; other site
340322007700 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
340322007701 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
340322007702 inhibitor site; inhibition site
340322007703 active site
340322007704 dimer interface [polypeptide binding]; other site
340322007705 catalytic residue [active]
340322007706 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
340322007707 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
340322007708 nucleotide binding site [chemical binding]; other site
340322007709 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
340322007710 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
340322007711 putative active site cavity [active]
340322007712 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
340322007713 catalytic site [active]
340322007714 Asp-box motif; other site
340322007715 Transcriptional regulators [Transcription]; Region: FadR; COG2186
340322007716 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
340322007717 DNA-binding site [nucleotide binding]; DNA binding site
340322007718 FCD domain; Region: FCD; pfam07729
340322007719 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
340322007720 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
340322007721 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
340322007722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322007723 dimer interface [polypeptide binding]; other site
340322007724 conserved gate region; other site
340322007725 putative PBP binding loops; other site
340322007726 ABC-ATPase subunit interface; other site
340322007727 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
340322007728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340322007729 dimer interface [polypeptide binding]; other site
340322007730 conserved gate region; other site
340322007731 putative PBP binding loops; other site
340322007732 ABC-ATPase subunit interface; other site
340322007733 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
340322007734 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
340322007735 Walker A/P-loop; other site
340322007736 ATP binding site [chemical binding]; other site
340322007737 Q-loop/lid; other site
340322007738 ABC transporter signature motif; other site
340322007739 Walker B; other site
340322007740 D-loop; other site
340322007741 H-loop/switch region; other site
340322007742 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
340322007743 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
340322007744 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
340322007745 Walker A/P-loop; other site
340322007746 ATP binding site [chemical binding]; other site
340322007747 Q-loop/lid; other site
340322007748 ABC transporter signature motif; other site
340322007749 Walker B; other site
340322007750 D-loop; other site
340322007751 H-loop/switch region; other site
340322007752 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
340322007753 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
340322007754 Transcriptional regulators [Transcription]; Region: Lrp; COG1522
340322007755 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
340322007756 putative DNA binding site [nucleotide binding]; other site
340322007757 putative Zn2+ binding site [ion binding]; other site
340322007758 AsnC family; Region: AsnC_trans_reg; pfam01037
340322007759 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
340322007760 homotrimer interaction site [polypeptide binding]; other site
340322007761 zinc binding site [ion binding]; other site
340322007762 CDP-binding sites; other site
340322007763 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
340322007764 substrate binding site; other site
340322007765 dimer interface; other site
340322007766 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
340322007767 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
340322007768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
340322007769 active site
340322007770 phosphorylation site [posttranslational modification]
340322007771 intermolecular recognition site; other site
340322007772 dimerization interface [polypeptide binding]; other site
340322007773 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
340322007774 DNA binding site [nucleotide binding]
340322007775 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
340322007776 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
340322007777 dimerization interface [polypeptide binding]; other site
340322007778 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
340322007779 dimer interface [polypeptide binding]; other site
340322007780 phosphorylation site [posttranslational modification]
340322007781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
340322007782 ATP binding site [chemical binding]; other site
340322007783 Mg2+ binding site [ion binding]; other site
340322007784 G-X-G motif; other site
340322007785 DNA repair protein RadA; Provisional; Region: PRK11823
340322007786 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
340322007787 Walker A motif; other site
340322007788 ATP binding site [chemical binding]; other site
340322007789 Walker B motif; other site
340322007790 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
340322007791 Predicted nucleic-acid-binding protein (contains the HHH domain) [General function prediction only]; Region: COG1623
340322007792 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
340322007793 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
340322007794 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151
340322007795 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
340322007796 NAD(P) binding site [chemical binding]; other site
340322007797 catalytic residues [active]
340322007798 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
340322007799 active site clefts [active]
340322007800 zinc binding site [ion binding]; other site
340322007801 dimer interface [polypeptide binding]; other site
340322007802 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
340322007803 endonuclease III; Region: ENDO3c; smart00478
340322007804 minor groove reading motif; other site
340322007805 helix-hairpin-helix signature motif; other site
340322007806 substrate binding pocket [chemical binding]; other site
340322007807 active site
340322007808 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
340322007809 Mono-functional DNA-alkylating methyl methanesulfonate N-term; Region: MMS1_N; pfam10433
340322007810 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
340322007811 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
340322007812 acetoin reductases; Region: 23BDH; TIGR02415
340322007813 NAD binding site [chemical binding]; other site
340322007814 homotetramer interface [polypeptide binding]; other site
340322007815 homodimer interface [polypeptide binding]; other site
340322007816 active site
340322007817 substrate binding site [chemical binding]; other site
340322007818 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
340322007819 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
340322007820 Clp amino terminal domain; Region: Clp_N; pfam02861
340322007821 Clp amino terminal domain; Region: Clp_N; pfam02861
340322007822 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340322007823 Walker A motif; other site
340322007824 ATP binding site [chemical binding]; other site
340322007825 Walker B motif; other site
340322007826 arginine finger; other site
340322007827 UvrB/uvrC motif; Region: UVR; pfam02151
340322007828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340322007829 Walker A motif; other site
340322007830 ATP binding site [chemical binding]; other site
340322007831 Walker B motif; other site
340322007832 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
340322007833 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
340322007834 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516
340322007835 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
340322007836 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
340322007837 active site
340322007838 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
340322007839 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
340322007840 phenol 2-monooxygenase; Provisional; Region: PRK08294
340322007841 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979
340322007842 dimer interface [polypeptide binding]; other site
340322007843 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722
340322007844 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
340322007845 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
340322007846 Major Facilitator Superfamily; Region: MFS_1; pfam07690
340322007847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322007848 putative substrate translocation pore; other site
340322007849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322007850 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
340322007851 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
340322007852 dimer interface [polypeptide binding]; other site
340322007853 putative anticodon binding site; other site
340322007854 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
340322007855 motif 1; other site
340322007856 dimer interface [polypeptide binding]; other site
340322007857 active site
340322007858 motif 2; other site
340322007859 motif 3; other site
340322007860 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
340322007861 pantoate--beta-alanine ligase; Region: panC; TIGR00018
340322007862 active site
340322007863 nucleotide binding site [chemical binding]; other site
340322007864 HIGH motif; other site
340322007865 KMSKS motif; other site
340322007866 Rossmann-like domain; Region: Rossmann-like; pfam10727
340322007867 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
340322007868 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
340322007869 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
340322007870 catalytic center binding site [active]
340322007871 ATP binding site [chemical binding]; other site
340322007872 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
340322007873 homooctamer interface [polypeptide binding]; other site
340322007874 active site
340322007875 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
340322007876 dihydropteroate synthase; Region: DHPS; TIGR01496
340322007877 substrate binding pocket [chemical binding]; other site
340322007878 dimer interface [polypeptide binding]; other site
340322007879 inhibitor binding site; inhibition site
340322007880 GTP cyclohydrolase I; Provisional; Region: PLN03044
340322007881 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642
340322007882 homodecamer interface [polypeptide binding]; other site
340322007883 active site
340322007884 putative catalytic site residues [active]
340322007885 zinc binding site [ion binding]; other site
340322007886 GTP-CH-I/GFRP interaction surface; other site
340322007887 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
340322007888 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340322007889 Walker A motif; other site
340322007890 ATP binding site [chemical binding]; other site
340322007891 Walker B motif; other site
340322007892 arginine finger; other site
340322007893 Peptidase family M41; Region: Peptidase_M41; pfam01434
340322007894 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
340322007895 active site
340322007896 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
340322007897 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
340322007898 Ligand Binding Site [chemical binding]; other site
340322007899 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
340322007900 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
340322007901 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
340322007902 dimer interface [polypeptide binding]; other site
340322007903 substrate binding site [chemical binding]; other site
340322007904 metal binding sites [ion binding]; metal-binding site
340322007905 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262
340322007906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340322007907 S-adenosylmethionine binding site [chemical binding]; other site
340322007908 Predicted membrane protein [Function unknown]; Region: COG3766
340322007909 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
340322007910 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042
340322007911 Protein of unknown function DUF2617; Region: DUF2617; pfam10936
340322007912 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
340322007913 CAT RNA binding domain; Region: CAT_RBD; smart01061
340322007914 transcriptional antiterminator BglG; Provisional; Region: PRK09772
340322007915 PRD domain; Region: PRD; pfam00874
340322007916 PRD domain; Region: PRD; pfam00874
340322007917 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
340322007918 beta-galactosidase; Region: BGL; TIGR03356
340322007919 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
340322007920 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
340322007921 active site turn [active]
340322007922 phosphorylation site [posttranslational modification]
340322007923 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
340322007924 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
340322007925 HPr interaction site; other site
340322007926 glycerol kinase (GK) interaction site [polypeptide binding]; other site
340322007927 active site
340322007928 phosphorylation site [posttranslational modification]
340322007929 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
340322007930 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
340322007931 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
340322007932 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
340322007933 active site residue [active]
340322007934 Transcriptional regulators [Transcription]; Region: MarR; COG1846
340322007935 MarR family; Region: MarR; pfam01047
340322007936 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
340322007937 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
340322007938 acyl-activating enzyme (AAE) consensus motif; other site
340322007939 AMP binding site [chemical binding]; other site
340322007940 active site
340322007941 CoA binding site [chemical binding]; other site
340322007942 Phosphopantetheine attachment site; Region: PP-binding; pfam00550
340322007943 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
340322007944 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
340322007945 putative CoA binding site [chemical binding]; other site
340322007946 putative trimer interface [polypeptide binding]; other site
340322007947 Protein of unknown function (DUF3754); Region: DUF3754; pfam12576
340322007948 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
340322007949 putative trimer interface [polypeptide binding]; other site
340322007950 putative CoA binding site [chemical binding]; other site
340322007951 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407
340322007952 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101
340322007953 NAD(P) binding site [chemical binding]; other site
340322007954 catalytic residues [active]
340322007955 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
340322007956 chaperonin GroEL; Reviewed; Region: groEL; PRK12849
340322007957 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
340322007958 ring oligomerisation interface [polypeptide binding]; other site
340322007959 ATP/Mg binding site [chemical binding]; other site
340322007960 stacking interactions; other site
340322007961 hinge regions; other site
340322007962 Tubulin like; Region: Tubulin_2; pfam13809
340322007963 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
340322007964 metal ion-dependent adhesion site (MIDAS); other site
340322007965 hypothetical protein; Provisional; Region: PRK07907
340322007966 M20 Dipeptidases; Region: M20_Dipept_like; cd03893
340322007967 active site
340322007968 metal binding site [ion binding]; metal-binding site
340322007969 dimer interface [polypeptide binding]; other site
340322007970 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644
340322007971 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
340322007972 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
340322007973 Domain of unknown function (DUF4040); Region: DUF4040; cl00676
340322007974 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946
340322007975 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665
340322007976 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
340322007977 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
340322007978 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948
340322007979 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12592
340322007980 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
340322007981 carboxylate-amine ligase; Provisional; Region: PRK13517
340322007982 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
340322007983 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
340322007984 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
340322007985 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
340322007986 active site
340322007987 catalytic residues [active]
340322007988 metal binding site [ion binding]; metal-binding site
340322007989 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
340322007990 Coenzyme A binding pocket [chemical binding]; other site
340322007991 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
340322007992 putative catalytic site [active]
340322007993 putative phosphate binding site [ion binding]; other site
340322007994 active site
340322007995 metal binding site A [ion binding]; metal-binding site
340322007996 DNA binding site [nucleotide binding]
340322007997 putative AP binding site [nucleotide binding]; other site
340322007998 putative metal binding site B [ion binding]; other site
340322007999 cardiolipin synthetase; Reviewed; Region: cls; PRK01642
340322008000 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
340322008001 putative active site [active]
340322008002 catalytic site [active]
340322008003 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
340322008004 putative active site [active]
340322008005 catalytic site [active]
340322008006 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
340322008007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322008008 putative substrate translocation pore; other site
340322008009 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
340322008010 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
340322008011 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
340322008012 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
340322008013 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
340322008014 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
340322008015 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
340322008016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322008017 Walker A/P-loop; other site
340322008018 ATP binding site [chemical binding]; other site
340322008019 Q-loop/lid; other site
340322008020 ABC transporter signature motif; other site
340322008021 Walker B; other site
340322008022 D-loop; other site
340322008023 H-loop/switch region; other site
340322008024 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
340322008025 nudix motif; other site
340322008026 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
340322008027 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
340322008028 substrate binding pocket [chemical binding]; other site
340322008029 membrane-bound complex binding site; other site
340322008030 hinge residues; other site
340322008031 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
340322008032 Catalytic domain of Protein Kinases; Region: PKc; cd00180
340322008033 active site
340322008034 ATP binding site [chemical binding]; other site
340322008035 substrate binding site [chemical binding]; other site
340322008036 activation loop (A-loop); other site
340322008037 propionate/acetate kinase; Provisional; Region: PRK12379
340322008038 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
340322008039 phosphotransacetylase; Reviewed; Region: eutD; PRK09653
340322008040 ferredoxin-NADP+ reductase; Region: PLN02852
340322008041 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
340322008042 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153
340322008043 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
340322008044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
340322008045 ATP-grasp domain; Region: ATP-grasp; pfam02222
340322008046 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
340322008047 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
340322008048 GDP-binding site [chemical binding]; other site
340322008049 ACT binding site; other site
340322008050 IMP binding site; other site
340322008051 cardiolipin synthetase; Reviewed; Region: PRK12452
340322008052 Predicted membrane protein [Function unknown]; Region: COG4129
340322008053 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
340322008054 fructose-bisphosphate aldolase; Provisional; Region: PRK09197
340322008055 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
340322008056 active site
340322008057 intersubunit interface [polypeptide binding]; other site
340322008058 zinc binding site [ion binding]; other site
340322008059 Na+ binding site [ion binding]; other site
340322008060 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
340322008061 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
340322008062 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
340322008063 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
340322008064 active site
340322008065 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
340322008066 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
340322008067 active site residue [active]
340322008068 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
340322008069 active site residue [active]
340322008070 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340322008071 sequence-specific DNA binding site [nucleotide binding]; other site
340322008072 salt bridge; other site
340322008073 H+ Antiporter protein; Region: 2A0121; TIGR00900
340322008074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322008075 putative substrate translocation pore; other site
340322008076 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085
340322008077 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
340322008078 Clp amino terminal domain; Region: Clp_N; pfam02861
340322008079 Clp amino terminal domain; Region: Clp_N; pfam02861
340322008080 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340322008081 Walker A motif; other site
340322008082 ATP binding site [chemical binding]; other site
340322008083 Walker B motif; other site
340322008084 arginine finger; other site
340322008085 Protein of unknown function (DUF2730); Region: DUF2730; pfam10805
340322008086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340322008087 Walker A motif; other site
340322008088 ATP binding site [chemical binding]; other site
340322008089 Walker B motif; other site
340322008090 arginine finger; other site
340322008091 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
340322008092 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
340322008093 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
340322008094 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
340322008095 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
340322008096 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
340322008097 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
340322008098 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
340322008099 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
340322008100 Coenzyme A binding pocket [chemical binding]; other site
340322008101 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
340322008102 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
340322008103 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
340322008104 FAD binding pocket [chemical binding]; other site
340322008105 conserved FAD binding motif [chemical binding]; other site
340322008106 phosphate binding motif [ion binding]; other site
340322008107 beta-alpha-beta structure motif; other site
340322008108 NAD binding pocket [chemical binding]; other site
340322008109 Predicted amidohydrolase [General function prediction only]; Region: COG0388
340322008110 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
340322008111 putative active site [active]
340322008112 catalytic triad [active]
340322008113 putative dimer interface [polypeptide binding]; other site
340322008114 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
340322008115 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
340322008116 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
340322008117 NAD(P) binding site [chemical binding]; other site
340322008118 catalytic residues [active]
340322008119 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
340322008120 DNA binding residues [nucleotide binding]
340322008121 MerR HTH family regulatory protein; Region: MerR_1; pfam13411
340322008122 putative dimer interface [polypeptide binding]; other site
340322008123 chaperone protein DnaJ; Provisional; Region: PRK14279
340322008124 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
340322008125 HSP70 interaction site [polypeptide binding]; other site
340322008126 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
340322008127 Zn binding sites [ion binding]; other site
340322008128 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
340322008129 dimer interface [polypeptide binding]; other site
340322008130 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
340322008131 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
340322008132 dimer interface [polypeptide binding]; other site
340322008133 hsp70 (ATPase domain) interactions [polypeptide binding]; other site
340322008134 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
340322008135 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
340322008136 nucleotide binding site [chemical binding]; other site
340322008137 NEF interaction site [polypeptide binding]; other site
340322008138 SBD interface [polypeptide binding]; other site
340322008139 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
340322008140 Domain of unknown function DUF20; Region: UPF0118; pfam01594
340322008141 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983
340322008142 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
340322008143 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
340322008144 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
340322008145 NAD binding site [chemical binding]; other site
340322008146 substrate binding site [chemical binding]; other site
340322008147 catalytic Zn binding site [ion binding]; other site
340322008148 tetramer interface [polypeptide binding]; other site
340322008149 structural Zn binding site [ion binding]; other site
340322008150 Cadherin repeat-like domain; Region: CA_like; cl15786
340322008151 Sulfite exporter TauE/SafE; Region: TauE; pfam01925
340322008152 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
340322008153 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
340322008154 putative active site [active]
340322008155 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
340322008156 active site
340322008157 sulfate adenylyltransferase, large subunit; Region: CysN; TIGR02034
340322008158 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
340322008159 CysD dimerization site [polypeptide binding]; other site
340322008160 G1 box; other site
340322008161 putative GEF interaction site [polypeptide binding]; other site
340322008162 GTP/Mg2+ binding site [chemical binding]; other site
340322008163 Switch I region; other site
340322008164 G2 box; other site
340322008165 G3 box; other site
340322008166 Switch II region; other site
340322008167 G4 box; other site
340322008168 G5 box; other site
340322008169 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
340322008170 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786
340322008171 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
340322008172 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
340322008173 Active Sites [active]
340322008174 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
340322008175 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
340322008176 Active Sites [active]
340322008177 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
340322008178 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
340322008179 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
340322008180 ferredoxin-NADP+ reductase; Region: PLN02852
340322008181 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
340322008182 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
340322008183 dimer interface [polypeptide binding]; other site
340322008184 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
340322008185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
340322008186 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
340322008187 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
340322008188 Predicted ATPase [General function prediction only]; Region: COG3910
340322008189 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
340322008190 Walker A/P-loop; other site
340322008191 ATP binding site [chemical binding]; other site
340322008192 Q-loop/lid; other site
340322008193 ABC transporter signature motif; other site
340322008194 Walker B; other site
340322008195 D-loop; other site
340322008196 H-loop/switch region; other site
340322008197 Predicted ATPase [General function prediction only]; Region: COG3910
340322008198 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
340322008199 Walker A/P-loop; other site
340322008200 ATP binding site [chemical binding]; other site
340322008201 Q-loop/lid; other site
340322008202 ABC transporter signature motif; other site
340322008203 Walker B; other site
340322008204 D-loop; other site
340322008205 H-loop/switch region; other site
340322008206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322008207 Major Facilitator Superfamily; Region: MFS_1; pfam07690
340322008208 putative substrate translocation pore; other site
340322008209 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
340322008210 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
340322008211 putative metal binding site [ion binding]; other site
340322008212 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
340322008213 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340322008214 Walker A/P-loop; other site
340322008215 ATP binding site [chemical binding]; other site
340322008216 Q-loop/lid; other site
340322008217 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
340322008218 ABC transporter signature motif; other site
340322008219 Walker B; other site
340322008220 D-loop; other site
340322008221 H-loop/switch region; other site
340322008222 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
340322008223 Walker A/P-loop; other site
340322008224 ATP binding site [chemical binding]; other site
340322008225 Q-loop/lid; other site
340322008226 ABC transporter signature motif; other site
340322008227 Walker B; other site
340322008228 D-loop; other site
340322008229 H-loop/switch region; other site
340322008230 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
340322008231 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
340322008232 dimer interface [polypeptide binding]; other site
340322008233 FMN binding site [chemical binding]; other site
340322008234 NADPH bind site [chemical binding]; other site
340322008235 Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; Region: URH1; COG1957
340322008236 active site
340322008237 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
340322008238 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402
340322008239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
340322008240 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
340322008241 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
340322008242 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
340322008243 heme-binding site [chemical binding]; other site
340322008244 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
340322008245 FAD binding pocket [chemical binding]; other site
340322008246 FAD binding motif [chemical binding]; other site
340322008247 phosphate binding motif [ion binding]; other site
340322008248 beta-alpha-beta structure motif; other site
340322008249 NAD binding pocket [chemical binding]; other site
340322008250 Heme binding pocket [chemical binding]; other site
340322008251 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
340322008252 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
340322008253 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
340322008254 CAT RNA binding domain; Region: CAT_RBD; smart01061
340322008255 transcriptional antiterminator BglG; Provisional; Region: PRK09772
340322008256 PRD domain; Region: PRD; pfam00874
340322008257 PRD domain; Region: PRD; pfam00874
340322008258 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
340322008259 beta-galactosidase; Region: BGL; TIGR03356
340322008260 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
340322008261 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
340322008262 active site turn [active]
340322008263 phosphorylation site [posttranslational modification]
340322008264 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
340322008265 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
340322008266 HPr interaction site; other site
340322008267 glycerol kinase (GK) interaction site [polypeptide binding]; other site
340322008268 active site
340322008269 phosphorylation site [posttranslational modification]
340322008270 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957
340322008271 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
340322008272 intersubunit interface [polypeptide binding]; other site
340322008273 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
340322008274 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
340322008275 ABC-ATPase subunit interface; other site
340322008276 dimer interface [polypeptide binding]; other site
340322008277 putative PBP binding regions; other site
340322008278 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
340322008279 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
340322008280 ABC-ATPase subunit interface; other site
340322008281 dimer interface [polypeptide binding]; other site
340322008282 putative PBP binding regions; other site
340322008283 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
340322008284 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
340322008285 Walker A/P-loop; other site
340322008286 ATP binding site [chemical binding]; other site
340322008287 Q-loop/lid; other site
340322008288 ABC transporter signature motif; other site
340322008289 Walker B; other site
340322008290 D-loop; other site
340322008291 H-loop/switch region; other site
340322008292 aminotransferase AlaT; Validated; Region: PRK09265
340322008293 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
340322008294 pyridoxal 5'-phosphate binding site [chemical binding]; other site
340322008295 homodimer interface [polypeptide binding]; other site
340322008296 catalytic residue [active]
340322008297 Predicted multitransmembrane protein [Function unknown]; Region: COG5438
340322008298 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
340322008299 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
340322008300 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
340322008301 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
340322008302 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
340322008303 trimer interface [polypeptide binding]; other site
340322008304 active site
340322008305 Htaa; Region: HtaA; pfam04213
340322008306 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
340322008307 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
340322008308 VanW like protein; Region: VanW; pfam04294
340322008309 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
340322008310 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
340322008311 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
340322008312 Ligand Binding Site [chemical binding]; other site
340322008313 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021
340322008314 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
340322008315 Predicted acyltransferases [Lipid metabolism]; Region: COG1835
340322008316 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
340322008317 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
340322008318 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
340322008319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340322008320 S-adenosylmethionine binding site [chemical binding]; other site
340322008321 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
340322008322 active site
340322008323 substrate-binding site [chemical binding]; other site
340322008324 metal-binding site [ion binding]
340322008325 GTP binding site [chemical binding]; other site
340322008326 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
340322008327 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320
340322008328 gating phenylalanine in ion channel; other site
340322008329 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340322008330 S-adenosylmethionine binding site [chemical binding]; other site
340322008331 LabA_like proteins; Region: LabA_like; cd06167
340322008332 putative metal binding site [ion binding]; other site
340322008333 MMPL family; Region: MMPL; pfam03176
340322008334 MMPL family; Region: MMPL; pfam03176
340322008335 Predicted integral membrane protein [Function unknown]; Region: COG0392
340322008336 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
340322008337 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
340322008338 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
340322008339 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
340322008340 Phosphopantetheine attachment site; Region: PKS_PP; smart00823
340322008341 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
340322008342 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
340322008343 active site
340322008344 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
340322008345 Phosphopantetheine attachment site; Region: PKS_PP; smart00823
340322008346 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
340322008347 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
340322008348 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
340322008349 acyl-activating enzyme (AAE) consensus motif; other site
340322008350 active site
340322008351 Cutinase; Region: Cutinase; pfam01083
340322008352 Putative esterase; Region: Esterase; pfam00756
340322008353 S-formylglutathione hydrolase; Region: PLN02442
340322008354 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
340322008355 LGFP repeat; Region: LGFP; pfam08310
340322008356 LGFP repeat; Region: LGFP; pfam08310
340322008357 LGFP repeat; Region: LGFP; pfam08310
340322008358 Domain of unknown function (DUF222); Region: DUF222; pfam02720
340322008359 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
340322008360 active site
340322008361 Putative esterase; Region: Esterase; pfam00756
340322008362 S-formylglutathione hydrolase; Region: PLN02442
340322008363 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
340322008364 UbiA prenyltransferase family; Region: UbiA; pfam01040
340322008365 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
340322008366 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
340322008367 active site
340322008368 Predicted glycosyltransferases [General function prediction only]; Region: COG1216
340322008369 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
340322008370 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
340322008371 active site
340322008372 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
340322008373 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
340322008374 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
340322008375 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
340322008376 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
340322008377 UDP-galactopyranose mutase; Region: GLF; pfam03275
340322008378 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
340322008379 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
340322008380 amidase catalytic site [active]
340322008381 Zn binding residues [ion binding]; other site
340322008382 substrate binding site [chemical binding]; other site
340322008383 LGFP repeat; Region: LGFP; pfam08310
340322008384 glycerol kinase; Provisional; Region: glpK; PRK00047
340322008385 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
340322008386 N- and C-terminal domain interface [polypeptide binding]; other site
340322008387 active site
340322008388 MgATP binding site [chemical binding]; other site
340322008389 catalytic site [active]
340322008390 metal binding site [ion binding]; metal-binding site
340322008391 putative homotetramer interface [polypeptide binding]; other site
340322008392 glycerol binding site [chemical binding]; other site
340322008393 homodimer interface [polypeptide binding]; other site
340322008394 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
340322008395 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
340322008396 active site
340322008397 motif I; other site
340322008398 motif II; other site
340322008399 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
340322008400 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
340322008401 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
340322008402 putative acyl-acceptor binding pocket; other site
340322008403 seryl-tRNA synthetase; Provisional; Region: PRK05431
340322008404 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
340322008405 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
340322008406 dimer interface [polypeptide binding]; other site
340322008407 active site
340322008408 motif 1; other site
340322008409 motif 2; other site
340322008410 motif 3; other site
340322008411 Transcriptional regulators [Transcription]; Region: PhnF; COG2188
340322008412 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
340322008413 DNA-binding site [nucleotide binding]; DNA binding site
340322008414 UTRA domain; Region: UTRA; pfam07702
340322008415 Septum formation; Region: Septum_form; pfam13845
340322008416 Septum formation; Region: Septum_form; pfam13845
340322008417 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
340322008418 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
340322008419 catalytic core [active]
340322008420 prephenate dehydratase; Provisional; Region: PRK11898
340322008421 Prephenate dehydratase; Region: PDT; pfam00800
340322008422 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
340322008423 putative L-Phe binding site [chemical binding]; other site
340322008424 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
340322008425 Amidase; Region: Amidase; cl11426
340322008426 CAAX protease self-immunity; Region: Abi; pfam02517
340322008427 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
340322008428 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
340322008429 active site
340322008430 catalytic site [active]
340322008431 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
340322008432 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
340322008433 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
340322008434 active site
340322008435 catalytic site [active]
340322008436 Transcriptional regulator [Transcription]; Region: LytR; COG1316
340322008437 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
340322008438 T5orf172 domain; Region: T5orf172; pfam10544
340322008439 YheO-like PAS domain; Region: PAS_6; pfam08348
340322008440 HTH domain; Region: HTH_22; pfam13309
340322008441 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
340322008442 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
340322008443 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
340322008444 active site
340322008445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322008446 metabolite-proton symporter; Region: 2A0106; TIGR00883
340322008447 putative substrate translocation pore; other site
340322008448 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
340322008449 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
340322008450 pyridoxal 5'-phosphate binding site [chemical binding]; other site
340322008451 homodimer interface [polypeptide binding]; other site
340322008452 catalytic residue [active]
340322008453 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
340322008454 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
340322008455 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
340322008456 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
340322008457 putative active site [active]
340322008458 catalytic site [active]
340322008459 putative metal binding site [ion binding]; other site
340322008460 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
340322008461 fructuronate transporter; Provisional; Region: PRK10034; cl15264
340322008462 Transcriptional regulators [Transcription]; Region: FadR; COG2186
340322008463 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
340322008464 DNA-binding site [nucleotide binding]; DNA binding site
340322008465 FCD domain; Region: FCD; pfam07729
340322008466 L-asparaginase II; Region: Asparaginase_II; pfam06089
340322008467 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
340322008468 Aspartase; Region: Aspartase; cd01357
340322008469 active sites [active]
340322008470 tetramer interface [polypeptide binding]; other site
340322008471 L-asparagine permease; Provisional; Region: PRK15049
340322008472 pyruvate kinase; Provisional; Region: PRK14725
340322008473 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
340322008474 active site
340322008475 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
340322008476 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
340322008477 tetramer (dimer of dimers) interface [polypeptide binding]; other site
340322008478 NAD binding site [chemical binding]; other site
340322008479 dimer interface [polypeptide binding]; other site
340322008480 substrate binding site [chemical binding]; other site
340322008481 Predicted membrane protein [Function unknown]; Region: COG4425
340322008482 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
340322008483 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
340322008484 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
340322008485 motif II; other site
340322008486 Predicted flavoprotein [General function prediction only]; Region: COG0431
340322008487 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
340322008488 Transcriptional regulators [Transcription]; Region: FadR; COG2186
340322008489 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
340322008490 DNA-binding site [nucleotide binding]; DNA binding site
340322008491 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
340322008492 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
340322008493 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
340322008494 active site
340322008495 metal binding site [ion binding]; metal-binding site
340322008496 metabolite-proton symporter; Region: 2A0106; TIGR00883
340322008497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322008498 putative substrate translocation pore; other site
340322008499 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
340322008500 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
340322008501 active site
340322008502 substrate binding site [chemical binding]; other site
340322008503 FMN binding site [chemical binding]; other site
340322008504 putative catalytic residues [active]
340322008505 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
340322008506 pentamer interface [polypeptide binding]; other site
340322008507 dodecaamer interface [polypeptide binding]; other site
340322008508 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
340322008509 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
340322008510 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
340322008511 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
340322008512 DNA-binding site [nucleotide binding]; DNA binding site
340322008513 FCD domain; Region: FCD; pfam07729
340322008514 FAD dependent oxidoreductase; Region: DAO; pfam01266
340322008515 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
340322008516 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
340322008517 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
340322008518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
340322008519 aldehyde dehydrogenase family 7 member; Region: PLN02315
340322008520 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
340322008521 tetrameric interface [polypeptide binding]; other site
340322008522 NAD binding site [chemical binding]; other site
340322008523 catalytic residues [active]
340322008524 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
340322008525 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
340322008526 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
340322008527 NAD(P) binding site [chemical binding]; other site
340322008528 Uncharacterized conserved protein [Function unknown]; Region: COG4894
340322008529 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
340322008530 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
340322008531 metal binding site [ion binding]; metal-binding site
340322008532 putative dimer interface [polypeptide binding]; other site
340322008533 methionine sulfoxide reductase A; Provisional; Region: PRK00058
340322008534 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
340322008535 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
340322008536 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
340322008537 Transcriptional regulator [Transcription]; Region: LysR; COG0583
340322008538 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
340322008539 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
340322008540 putative dimerization interface [polypeptide binding]; other site
340322008541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322008542 putative substrate translocation pore; other site
340322008543 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
340322008544 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
340322008545 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
340322008546 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
340322008547 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
340322008548 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
340322008549 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
340322008550 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
340322008551 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
340322008552 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
340322008553 NAD(P) binding site [chemical binding]; other site
340322008554 active site
340322008555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322008556 putative substrate translocation pore; other site
340322008557 Transcriptional regulators [Transcription]; Region: MarR; COG1846
340322008558 MarR family; Region: MarR_2; pfam12802
340322008559 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
340322008560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
340322008561 active site
340322008562 phosphorylation site [posttranslational modification]
340322008563 intermolecular recognition site; other site
340322008564 dimerization interface [polypeptide binding]; other site
340322008565 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
340322008566 DNA binding residues [nucleotide binding]
340322008567 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
340322008568 Histidine kinase; Region: HisKA_3; pfam07730
340322008569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
340322008570 ATP binding site [chemical binding]; other site
340322008571 Mg2+ binding site [ion binding]; other site
340322008572 G-X-G motif; other site
340322008573 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449
340322008574 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
340322008575 active site
340322008576 catalytic site [active]
340322008577 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247
340322008578 60Kd inner membrane protein; Region: 60KD_IMP; cl00489
340322008579 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
340322008580 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
340322008581 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
340322008582 Ligand Binding Site [chemical binding]; other site
340322008583 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
340322008584 Ligand Binding Site [chemical binding]; other site
340322008585 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
340322008586 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
340322008587 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
340322008588 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558
340322008589 probable active site [active]
340322008590 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
340322008591 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
340322008592 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358
340322008593 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
340322008594 putative ligand binding site [chemical binding]; other site
340322008595 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
340322008596 MarR family; Region: MarR_2; pfam12802
340322008597 Predicted transcriptional regulators [Transcription]; Region: COG1725
340322008598 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
340322008599 DNA-binding site [nucleotide binding]; DNA binding site
340322008600 LabA_like proteins; Region: LabA_like; cd06167
340322008601 putative metal binding site [ion binding]; other site
340322008602 Uncharacterized conserved protein [Function unknown]; Region: COG1432
340322008603 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
340322008604 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
340322008605 Thioredoxin-like; Region: Thioredoxin_8; pfam13905
340322008606 catalytic residues [active]
340322008607 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
340322008608 metal-binding site [ion binding]
340322008609 benzoate transport; Region: 2A0115; TIGR00895
340322008610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322008611 putative substrate translocation pore; other site
340322008612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322008613 Predicted transcriptional regulators [Transcription]; Region: COG1695
340322008614 Transcriptional regulator PadR-like family; Region: PadR; pfam03551
340322008615 replicative DNA helicase; Provisional; Region: PRK05636
340322008616 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
340322008617 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
340322008618 Walker A motif; other site
340322008619 ATP binding site [chemical binding]; other site
340322008620 Walker B motif; other site
340322008621 DNA binding loops [nucleotide binding]
340322008622 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
340322008623 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
340322008624 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
340322008625 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
340322008626 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
340322008627 dimer interface [polypeptide binding]; other site
340322008628 ssDNA binding site [nucleotide binding]; other site
340322008629 tetramer (dimer of dimers) interface [polypeptide binding]; other site
340322008630 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
340322008631 Predicted integral membrane protein [Function unknown]; Region: COG5650
340322008632 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
340322008633 Transglycosylase; Region: Transgly; pfam00912
340322008634 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
340322008635 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
340322008636 MarR family; Region: MarR; pfam01047
340322008637 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
340322008638 Ligand Binding Site [chemical binding]; other site
340322008639 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
340322008640 Ligand Binding Site [chemical binding]; other site
340322008641 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
340322008642 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
340322008643 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
340322008644 active site residue [active]
340322008645 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
340322008646 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
340322008647 FtsX-like permease family; Region: FtsX; pfam02687
340322008648 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
340322008649 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
340322008650 Walker A/P-loop; other site
340322008651 ATP binding site [chemical binding]; other site
340322008652 Q-loop/lid; other site
340322008653 ABC transporter signature motif; other site
340322008654 Walker B; other site
340322008655 D-loop; other site
340322008656 H-loop/switch region; other site
340322008657 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
340322008658 HlyD family secretion protein; Region: HlyD_3; pfam13437
340322008659 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
340322008660 inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450
340322008661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
340322008662 hypothetical protein; Provisional; Region: PRK13663
340322008663 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
340322008664 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
340322008665 dimerization interface [polypeptide binding]; other site
340322008666 DPS ferroxidase diiron center [ion binding]; other site
340322008667 ion pore; other site
340322008668 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
340322008669 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
340322008670 putative DNA binding site [nucleotide binding]; other site
340322008671 catalytic residue [active]
340322008672 putative H2TH interface [polypeptide binding]; other site
340322008673 putative catalytic residues [active]
340322008674 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
340322008675 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
340322008676 hypothetical protein; Reviewed; Region: PRK09588
340322008677 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
340322008678 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
340322008679 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
340322008680 DNA binding site [nucleotide binding]
340322008681 active site
340322008682 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
340322008683 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
340322008684 putative NAD(P) binding site [chemical binding]; other site
340322008685 dimer interface [polypeptide binding]; other site
340322008686 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
340322008687 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
340322008688 intersubunit interface [polypeptide binding]; other site
340322008689 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
340322008690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322008691 putative substrate translocation pore; other site
340322008692 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
340322008693 Malic enzyme, N-terminal domain; Region: malic; pfam00390
340322008694 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
340322008695 putative NAD(P) binding site [chemical binding]; other site
340322008696 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
340322008697 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
340322008698 N- and C-terminal domain interface [polypeptide binding]; other site
340322008699 active site
340322008700 catalytic site [active]
340322008701 metal binding site [ion binding]; metal-binding site
340322008702 carbohydrate binding site [chemical binding]; other site
340322008703 ATP binding site [chemical binding]; other site
340322008704 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
340322008705 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
340322008706 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
340322008707 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
340322008708 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
340322008709 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
340322008710 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
340322008711 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
340322008712 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
340322008713 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
340322008714 metal ion-dependent adhesion site (MIDAS); other site
340322008715 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
340322008716 putative FMN binding site [chemical binding]; other site
340322008717 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
340322008718 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
340322008719 HIGH motif; other site
340322008720 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
340322008721 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
340322008722 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
340322008723 active site
340322008724 KMSKS motif; other site
340322008725 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
340322008726 tRNA binding surface [nucleotide binding]; other site
340322008727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
340322008728 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
340322008729 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340322008730 non-specific DNA binding site [nucleotide binding]; other site
340322008731 salt bridge; other site
340322008732 sequence-specific DNA binding site [nucleotide binding]; other site
340322008733 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583
340322008734 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
340322008735 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398
340322008736 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
340322008737 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
340322008738 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435
340322008739 Cupin domain; Region: Cupin_2; pfam07883
340322008740 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
340322008741 Transcriptional regulator [Transcription]; Region: IclR; COG1414
340322008742 Bacterial transcriptional regulator; Region: IclR; pfam01614
340322008743 benzoate transport; Region: 2A0115; TIGR00895
340322008744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322008745 putative substrate translocation pore; other site
340322008746 salicylate hydroxylase; Provisional; Region: PRK08163
340322008747 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
340322008748 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
340322008749 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
340322008750 SdpI/YhfL protein family; Region: SdpI; pfam13630
340322008751 Predicted integral membrane protein [Function unknown]; Region: COG5658
340322008752 anthranilate synthase component I; Provisional; Region: PRK13564
340322008753 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
340322008754 chorismate binding enzyme; Region: Chorismate_bind; pfam00425
340322008755 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
340322008756 Glutamine amidotransferase class-I; Region: GATase; pfam00117
340322008757 glutamine binding [chemical binding]; other site
340322008758 catalytic triad [active]
340322008759 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
340322008760 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
340322008761 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
340322008762 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
340322008763 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
340322008764 active site
340322008765 ribulose/triose binding site [chemical binding]; other site
340322008766 phosphate binding site [ion binding]; other site
340322008767 substrate (anthranilate) binding pocket [chemical binding]; other site
340322008768 product (indole) binding pocket [chemical binding]; other site
340322008769 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
340322008770 active site
340322008771 tryptophan synthase, beta subunit; Region: trpB; TIGR00263
340322008772 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
340322008773 pyridoxal 5'-phosphate binding site [chemical binding]; other site
340322008774 catalytic residue [active]
340322008775 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
340322008776 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
340322008777 substrate binding site [chemical binding]; other site
340322008778 active site
340322008779 catalytic residues [active]
340322008780 heterodimer interface [polypeptide binding]; other site
340322008781 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
340322008782 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
340322008783 active site
340322008784 phosphorylation site [posttranslational modification]
340322008785 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
340322008786 active site
340322008787 P-loop; other site
340322008788 phosphorylation site [posttranslational modification]
340322008789 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
340322008790 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
340322008791 Walker A/P-loop; other site
340322008792 ATP binding site [chemical binding]; other site
340322008793 Q-loop/lid; other site
340322008794 ABC transporter signature motif; other site
340322008795 Walker B; other site
340322008796 D-loop; other site
340322008797 H-loop/switch region; other site
340322008798 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
340322008799 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
340322008800 iron-sulfur cluster [ion binding]; other site
340322008801 [2Fe-2S] cluster binding site [ion binding]; other site
340322008802 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
340322008803 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
340322008804 active site
340322008805 FMN binding site [chemical binding]; other site
340322008806 substrate binding site [chemical binding]; other site
340322008807 homotetramer interface [polypeptide binding]; other site
340322008808 catalytic residue [active]
340322008809 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
340322008810 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
340322008811 Uncharacterized conserved protein [Function unknown]; Region: COG3358
340322008812 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
340322008813 putative DNA binding site [nucleotide binding]; other site
340322008814 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
340322008815 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
340322008816 active site
340322008817 FMN binding site [chemical binding]; other site
340322008818 substrate binding site [chemical binding]; other site
340322008819 homotetramer interface [polypeptide binding]; other site
340322008820 catalytic residue [active]
340322008821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
340322008822 NADH(P)-binding; Region: NAD_binding_10; pfam13460
340322008823 NAD(P) binding site [chemical binding]; other site
340322008824 active site
340322008825 short chain dehydrogenase; Provisional; Region: PRK08267
340322008826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
340322008827 NAD(P) binding site [chemical binding]; other site
340322008828 active site
340322008829 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
340322008830 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
340322008831 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
340322008832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322008833 putative substrate translocation pore; other site
340322008834 POT family; Region: PTR2; cl17359
340322008835 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
340322008836 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
340322008837 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
340322008838 active site
340322008839 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
340322008840 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
340322008841 active site
340322008842 dimer interface [polypeptide binding]; other site
340322008843 metal binding site [ion binding]; metal-binding site
340322008844 Sugar (and other) transporter; Region: Sugar_tr; pfam00083
340322008845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322008846 putative substrate translocation pore; other site
340322008847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322008848 Transcriptional regulator [Transcription]; Region: IclR; COG1414
340322008849 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
340322008850 Transcriptional regulator [Transcription]; Region: IclR; COG1414
340322008851 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
340322008852 Bacterial transcriptional regulator; Region: IclR; pfam01614
340322008853 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
340322008854 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
340322008855 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
340322008856 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
340322008857 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
340322008858 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
340322008859 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
340322008860 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
340322008861 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
340322008862 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
340322008863 Lamin Tail Domain; Region: LTD; pfam00932
340322008864 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
340322008865 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399
340322008866 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
340322008867 putative active site [active]
340322008868 putative metal binding site [ion binding]; other site
340322008869 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
340322008870 classical (c) SDRs; Region: SDR_c; cd05233
340322008871 NAD(P) binding site [chemical binding]; other site
340322008872 active site
340322008873 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
340322008874 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
340322008875 acyl-activating enzyme (AAE) consensus motif; other site
340322008876 putative AMP binding site [chemical binding]; other site
340322008877 putative active site [active]
340322008878 putative CoA binding site [chemical binding]; other site
340322008879 benzoate transport; Region: 2A0115; TIGR00895
340322008880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322008881 putative substrate translocation pore; other site
340322008882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322008883 Transcriptional regulator [Transcription]; Region: IclR; COG1414
340322008884 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
340322008885 Bacterial transcriptional regulator; Region: IclR; pfam01614
340322008886 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
340322008887 active site
340322008888 proline/glycine betaine transporter; Provisional; Region: PRK10642
340322008889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340322008890 putative substrate translocation pore; other site
340322008891 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525
340322008892 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
340322008893 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
340322008894 homodimer interface [polypeptide binding]; other site
340322008895 chemical substrate binding site [chemical binding]; other site
340322008896 oligomer interface [polypeptide binding]; other site
340322008897 metal binding site [ion binding]; metal-binding site
340322008898 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
340322008899 catalytic site [active]
340322008900 metal binding site [ion binding]; metal-binding site
340322008901 AAA ATPase domain; Region: AAA_16; pfam13191
340322008902 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
340322008903 Uncharacterized conserved protein [Function unknown]; Region: COG3410
340322008904 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
340322008905 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
340322008906 siderophore binding site; other site
340322008907 2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292
340322008908 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
340322008909 putative NAD(P) binding site [chemical binding]; other site
340322008910 putative dimer interface [polypeptide binding]; other site
340322008911 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
340322008912 Protein of unknown function (DUF1304); Region: DUF1304; cl01533
340322008913 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
340322008914 substrate binding site [chemical binding]; other site
340322008915 dimer interface [polypeptide binding]; other site
340322008916 ATP binding site [chemical binding]; other site
340322008917 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
340322008918 metal-binding site [ion binding]
340322008919 Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687
340322008920 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
340322008921 hypothetical protein; Validated; Region: PRK00228
340322008922 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
340322008923 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
340322008924 active site
340322008925 NTP binding site [chemical binding]; other site
340322008926 metal binding triad [ion binding]; metal-binding site
340322008927 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
340322008928 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
340322008929 Zn2+ binding site [ion binding]; other site
340322008930 Mg2+ binding site [ion binding]; other site
340322008931 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
340322008932 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
340322008933 active site
340322008934 Ap6A binding site [chemical binding]; other site
340322008935 nudix motif; other site
340322008936 metal binding site [ion binding]; metal-binding site
340322008937 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
340322008938 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
340322008939 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
340322008940 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
340322008941 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
340322008942 DNA binding residues [nucleotide binding]
340322008943 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
340322008944 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
340322008945 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
340322008946 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
340322008947 catalytic residues [active]
340322008948 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
340322008949 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
340322008950 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
340322008951 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
340322008952 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
340322008953 active site
340322008954 metal binding site [ion binding]; metal-binding site
340322008955 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
340322008956 ParB-like nuclease domain; Region: ParB; smart00470
340322008957 KorB domain; Region: KorB; pfam08535
340322008958 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
340322008959 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
340322008960 P-loop; other site
340322008961 Magnesium ion binding site [ion binding]; other site
340322008962 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
340322008963 Magnesium ion binding site [ion binding]; other site
340322008964 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
340322008965 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
340322008966 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
340322008967 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449
340322008968 ribonuclease P; Reviewed; Region: rnpA; PRK03459
340322008969 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
340322008970 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
340322008971 dimer interface [polypeptide binding]; other site
340322008972 ssDNA binding site [nucleotide binding]; other site
340322008973 tetramer (dimer of dimers) interface [polypeptide binding]; other site
340322008974 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
340322008975 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
340322008976 phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542
340322008977 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
340322008978 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
340322008979 Minor capsid protein; Region: Minor_capsid_2; pfam11114
340322008980 tape measure domain; Region: tape_meas_nterm; TIGR02675
340322008981 Secretion system effector C (SseC) like family; Region: SseC; pfam04888
340322008982 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
340322008983 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
340322008984 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
340322008985 Walker A motif; other site
340322008986 ATP binding site [chemical binding]; other site
340322008987 Walker B motif; other site
340322008988 DNA binding loops [nucleotide binding]