-- dump date   	20140619_050528
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
548476000001	Plasmid encoded RepA protein; Region: RepA_C; pfam04796
548476000002	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548476000003	Transposase; Region: HTH_Tnp_1; cl17663
548476000004	putative transposase OrfB; Reviewed; Region: PHA02517
548476000005	HTH-like domain; Region: HTH_21; pfam13276
548476000006	Integrase core domain; Region: rve; pfam00665
548476000007	Integrase core domain; Region: rve_3; pfam13683
548476000008	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
548476000009	dimerization interface [polypeptide binding]; other site
548476000010	putative DNA binding site [nucleotide binding]; other site
548476000011	putative Zn2+ binding site [ion binding]; other site
548476000016	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
548476000017	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
548476000018	catalytic residues [active]
548476000019	catalytic nucleophile [active]
548476000020	Presynaptic Site I dimer interface [polypeptide binding]; other site
548476000021	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
548476000022	Synaptic Flat tetramer interface [polypeptide binding]; other site
548476000023	Synaptic Site I dimer interface [polypeptide binding]; other site
548476000024	DNA binding site [nucleotide binding]
548476000025	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
548476000026	DNA-binding interface [nucleotide binding]; DNA binding site
548476000028	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
548476000029	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
548476000030	NADH(P)-binding; Region: NAD_binding_10; pfam13460
548476000031	NAD(P) binding site [chemical binding]; other site
548476000032	active site
548476000033	EamA-like transporter family; Region: EamA; pfam00892
548476000034	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
548476000035	EamA-like transporter family; Region: EamA; pfam00892
548476000036	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
548476000037	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
548476000038	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
548476000039	acyl-activating enzyme (AAE) consensus motif; other site
548476000040	AMP binding site [chemical binding]; other site
548476000041	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
548476000042	dimer interface [polypeptide binding]; other site
548476000043	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
548476000044	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
548476000045	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
548476000046	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
548476000047	active site
548476000048	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
548476000049	active site
548476000050	MarR family; Region: MarR_2; cl17246
548476000051	Transcriptional regulators [Transcription]; Region: MarR; COG1846
548476000053	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
548476000054	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
548476000055	P-loop; other site
548476000056	Magnesium ion binding site [ion binding]; other site
548476000057	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
548476000058	TrwC relaxase; Region: TrwC; pfam08751
548476000059	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
548476000060	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548476000061	Walker A motif; other site
548476000062	ATP binding site [chemical binding]; other site
548476000063	Walker B motif; other site
548476000064	Family description; Region: UvrD_C_2; pfam13538
548476000067	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548476000068	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
548476000069	Walker A motif; other site
548476000070	ATP binding site [chemical binding]; other site
548476000071	Walker B motif; other site
548476000072	arginine finger; other site
548476000073	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
548476000074	DnaA box-binding interface [nucleotide binding]; other site
548476000075	DNA polymerase III subunit beta; Validated; Region: PRK07761
548476000076	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
548476000077	putative DNA binding surface [nucleotide binding]; other site
548476000078	dimer interface [polypeptide binding]; other site
548476000079	beta-clamp/clamp loader binding surface; other site
548476000080	beta-clamp/translesion DNA polymerase binding surface; other site
548476000081	recombination protein F; Reviewed; Region: recF; PRK00064
548476000082	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
548476000083	Walker A/P-loop; other site
548476000084	ATP binding site [chemical binding]; other site
548476000085	Q-loop/lid; other site
548476000086	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548476000087	ABC transporter signature motif; other site
548476000088	Walker B; other site
548476000089	D-loop; other site
548476000090	H-loop/switch region; other site
548476000091	Protein of unknown function (DUF721); Region: DUF721; cl02324
548476000092	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
548476000093	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548476000094	ATP binding site [chemical binding]; other site
548476000095	Mg2+ binding site [ion binding]; other site
548476000096	G-X-G motif; other site
548476000097	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
548476000098	anchoring element; other site
548476000099	dimer interface [polypeptide binding]; other site
548476000100	ATP binding site [chemical binding]; other site
548476000101	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
548476000102	active site
548476000103	putative metal-binding site [ion binding]; other site
548476000104	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
548476000105	DNA gyrase subunit A; Validated; Region: PRK05560
548476000106	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
548476000107	CAP-like domain; other site
548476000108	active site
548476000109	primary dimer interface [polypeptide binding]; other site
548476000110	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
548476000111	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
548476000112	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
548476000113	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
548476000114	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
548476000115	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
548476000116	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
548476000117	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
548476000118	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
548476000119	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
548476000120	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
548476000121	Coenzyme A binding pocket [chemical binding]; other site
548476000122	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
548476000123	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
548476000124	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548476000125	Walker A/P-loop; other site
548476000126	ATP binding site [chemical binding]; other site
548476000127	Q-loop/lid; other site
548476000128	ABC transporter signature motif; other site
548476000129	Walker B; other site
548476000130	D-loop; other site
548476000131	H-loop/switch region; other site
548476000132	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
548476000133	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
548476000134	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
548476000135	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548476000136	ABC transporter signature motif; other site
548476000137	Walker B; other site
548476000138	D-loop; other site
548476000139	H-loop/switch region; other site
548476000140	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
548476000141	FAD binding site [chemical binding]; other site
548476000142	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
548476000143	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
548476000144	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
548476000145	substrate binding site [chemical binding]; other site
548476000146	THF binding site; other site
548476000147	zinc-binding site [ion binding]; other site
548476000148	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
548476000149	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548476000150	motif II; other site
548476000151	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
548476000152	active site
548476000153	Rhomboid family; Region: Rhomboid; pfam01694
548476000154	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
548476000155	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
548476000156	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548476000157	active site
548476000158	phosphorylation site [posttranslational modification]
548476000159	intermolecular recognition site; other site
548476000160	dimerization interface [polypeptide binding]; other site
548476000161	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
548476000162	dimerization interface [polypeptide binding]; other site
548476000163	DNA binding residues [nucleotide binding]
548476000164	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
548476000165	putative septation inhibitor protein; Reviewed; Region: PRK00159
548476000166	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
548476000167	Catalytic domain of Protein Kinases; Region: PKc; cd00180
548476000168	active site
548476000169	ATP binding site [chemical binding]; other site
548476000170	substrate binding site [chemical binding]; other site
548476000171	activation loop (A-loop); other site
548476000172	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
548476000173	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
548476000174	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
548476000175	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
548476000176	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
548476000177	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
548476000178	Catalytic domain of Protein Kinases; Region: PKc; cd00180
548476000179	active site
548476000180	ATP binding site [chemical binding]; other site
548476000181	substrate binding site [chemical binding]; other site
548476000182	activation loop (A-loop); other site
548476000183	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
548476000184	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
548476000185	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
548476000186	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
548476000187	Protein phosphatase 2C; Region: PP2C; pfam00481
548476000188	active site
548476000189	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
548476000190	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
548476000191	phosphopeptide binding site; other site
548476000192	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
548476000193	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
548476000194	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
548476000195	phosphopeptide binding site; other site
548476000196	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
548476000197	Secretory lipase; Region: LIP; pfam03583
548476000198	Predicted glycosyltransferase involved in capsule biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG4092
548476000199	putative transposase OrfB; Reviewed; Region: PHA02517
548476000200	HTH-like domain; Region: HTH_21; pfam13276
548476000201	Integrase core domain; Region: rve; pfam00665
548476000202	Integrase core domain; Region: rve_3; pfam13683
548476000203	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548476000204	Transposase; Region: HTH_Tnp_1; pfam01527
548476000205	HTH-like domain; Region: HTH_21; pfam13276
548476000206	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548476000207	Transposase; Region: HTH_Tnp_1; pfam01527
548476000208	Transposase, Mutator family; Region: Transposase_mut; pfam00872
548476000209	Transposase; Region: HTH_Tnp_1; cl17663
548476000210	HTH-like domain; Region: HTH_21; pfam13276
548476000211	Integrase core domain; Region: rve; pfam00665
548476000212	Integrase core domain; Region: rve; pfam00665
548476000213	putative transposase OrfB; Reviewed; Region: PHA02517
548476000214	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
548476000215	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
548476000216	acyl-activating enzyme (AAE) consensus motif; other site
548476000217	AMP binding site [chemical binding]; other site
548476000218	active site
548476000219	CoA binding site [chemical binding]; other site
548476000220	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
548476000221	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
548476000222	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
548476000223	putative trimer interface [polypeptide binding]; other site
548476000224	putative CoA binding site [chemical binding]; other site
548476000225	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
548476000226	putative trimer interface [polypeptide binding]; other site
548476000227	putative CoA binding site [chemical binding]; other site
548476000228	putative transposase OrfB; Reviewed; Region: PHA02517
548476000229	HTH-like domain; Region: HTH_21; pfam13276
548476000230	Integrase core domain; Region: rve; pfam00665
548476000231	Integrase core domain; Region: rve_3; pfam13683
548476000232	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548476000233	Transposase; Region: HTH_Tnp_1; cl17663
548476000234	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
548476000235	putative trimer interface [polypeptide binding]; other site
548476000236	putative CoA binding site [chemical binding]; other site
548476000237	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
548476000238	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
548476000239	putative transposase OrfB; Reviewed; Region: PHA02517
548476000240	HTH-like domain; Region: HTH_21; pfam13276
548476000241	Integrase core domain; Region: rve; pfam00665
548476000242	Integrase core domain; Region: rve_3; pfam13683
548476000243	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548476000244	Transposase; Region: HTH_Tnp_1; cl17663
548476000245	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548476000246	Transposase; Region: HTH_Tnp_1; pfam01527
548476000247	putative transposase OrfB; Reviewed; Region: PHA02517
548476000248	HTH-like domain; Region: HTH_21; pfam13276
548476000249	Integrase core domain; Region: rve; pfam00665
548476000250	Integrase core domain; Region: rve_3; pfam13683
548476000251	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548476000252	Transposase; Region: HTH_Tnp_1; cl17663
548476000253	putative transposase OrfB; Reviewed; Region: PHA02517
548476000254	HTH-like domain; Region: HTH_21; pfam13276
548476000255	Integrase core domain; Region: rve; pfam00665
548476000256	Integrase core domain; Region: rve_3; pfam13683
548476000257	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
548476000258	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
548476000259	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
548476000260	Lipase (class 2); Region: Lipase_2; pfam01674
548476000261	Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357
548476000262	CHY zinc finger; Region: zf-CHY; pfam05495
548476000263	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
548476000264	Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546
548476000265	putative metal binding site [ion binding]; other site
548476000266	biotin synthase; Validated; Region: PRK06256
548476000267	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
548476000268	FeS/SAM binding site; other site
548476000269	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
548476000270	NAD-dependent deacetylase; Provisional; Region: PRK05333
548476000271	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
548476000272	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
548476000273	Lipase (class 2); Region: Lipase_2; pfam01674
548476000274	AMP nucleosidase; Provisional; Region: PRK08292
548476000275	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
548476000276	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
548476000277	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
548476000278	active site
548476000279	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
548476000280	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
548476000281	Sulfate transporter family; Region: Sulfate_transp; pfam00916
548476000282	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
548476000283	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
548476000284	Ferritin-like domain; Region: Ferritin; pfam00210
548476000285	ferroxidase diiron center [ion binding]; other site
548476000286	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
548476000287	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
548476000288	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
548476000289	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805
548476000290	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
548476000291	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
548476000292	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
548476000293	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
548476000294	hypothetical protein; Provisional; Region: PRK10621
548476000295	HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643
548476000296	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
548476000297	ATP binding site [chemical binding]; other site
548476000298	putative Mg++ binding site [ion binding]; other site
548476000299	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
548476000300	nucleotide binding region [chemical binding]; other site
548476000301	ATP-binding site [chemical binding]; other site
548476000302	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
548476000303	galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527
548476000304	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
548476000305	active site
548476000306	substrate binding site [chemical binding]; other site
548476000307	trimer interface [polypeptide binding]; other site
548476000308	CoA binding site [chemical binding]; other site
548476000309	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
548476000310	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
548476000311	NAD(P) binding site [chemical binding]; other site
548476000312	active site
548476000313	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
548476000314	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
548476000315	NAD(P) binding site [chemical binding]; other site
548476000316	catalytic residues [active]
548476000317	BCCT family transporter; Region: BCCT; cl00569
548476000318	choline dehydrogenase; Validated; Region: PRK02106
548476000319	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
548476000320	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
548476000321	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
548476000322	RNA binding surface [nucleotide binding]; other site
548476000323	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
548476000324	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
548476000325	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
548476000326	active site
548476000327	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548476000328	Transposase; Region: HTH_Tnp_1; pfam01527
548476000329	putative transposase OrfB; Reviewed; Region: PHA02517
548476000330	HTH-like domain; Region: HTH_21; pfam13276
548476000331	Integrase core domain; Region: rve; pfam00665
548476000332	Integrase core domain; Region: rve_3; pfam13683
548476000333	Protease prsW family; Region: PrsW-protease; pfam13367
548476000334	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
548476000335	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
548476000336	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
548476000337	active site
548476000338	Zn binding site [ion binding]; other site
548476000339	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
548476000340	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
548476000341	Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
548476000342	Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249
548476000343	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
548476000344	classical (c) SDRs; Region: SDR_c; cd05233
548476000345	NAD(P) binding site [chemical binding]; other site
548476000346	active site
548476000347	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
548476000348	FAD binding domain; Region: FAD_binding_4; pfam01565
548476000349	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
548476000350	Predicted membrane protein [Function unknown]; Region: COG2246
548476000351	GtrA-like protein; Region: GtrA; pfam04138
548476000352	Predicted membrane protein [Function unknown]; Region: COG2246
548476000353	GtrA-like protein; Region: GtrA; pfam04138
548476000354	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
548476000355	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
548476000356	active site
548476000357	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
548476000358	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
548476000359	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
548476000360	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
548476000361	Walker A/P-loop; other site
548476000362	ATP binding site [chemical binding]; other site
548476000363	Q-loop/lid; other site
548476000364	ABC transporter signature motif; other site
548476000365	Walker B; other site
548476000366	D-loop; other site
548476000367	H-loop/switch region; other site
548476000368	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
548476000369	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
548476000370	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
548476000371	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
548476000372	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
548476000373	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
548476000374	NAD(P) binding site [chemical binding]; other site
548476000375	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
548476000376	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
548476000377	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
548476000378	NAD-dependent deacetylase; Provisional; Region: PRK00481
548476000379	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
548476000380	NAD+ binding site [chemical binding]; other site
548476000381	substrate binding site [chemical binding]; other site
548476000382	Zn binding site [ion binding]; other site
548476000383	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
548476000384	Domain of unknown function (DUF4288); Region: DUF4288; pfam14119
548476000385	molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597
548476000386	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
548476000387	ATP binding site [chemical binding]; other site
548476000388	substrate interface [chemical binding]; other site
548476000389	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
548476000390	active site residue [active]
548476000391	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
548476000392	MoaE homodimer interface [polypeptide binding]; other site
548476000393	MoaD interaction [polypeptide binding]; other site
548476000394	active site residues [active]
548476000395	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
548476000396	MPT binding site; other site
548476000397	trimer interface [polypeptide binding]; other site
548476000398	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
548476000399	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
548476000400	dimer interface [polypeptide binding]; other site
548476000401	putative functional site; other site
548476000402	putative MPT binding site; other site
548476000403	Ubiquitin-like proteins; Region: UBQ; cl00155
548476000404	charged pocket; other site
548476000405	hydrophobic patch; other site
548476000406	Membrane protein of unknown function; Region: DUF360; pfam04020
548476000407	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
548476000408	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
548476000409	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548476000410	homodimer interface [polypeptide binding]; other site
548476000411	catalytic residue [active]
548476000412	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
548476000413	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
548476000414	dimer interface [polypeptide binding]; other site
548476000415	PYR/PP interface [polypeptide binding]; other site
548476000416	TPP binding site [chemical binding]; other site
548476000417	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
548476000418	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
548476000419	TPP-binding site [chemical binding]; other site
548476000420	dimer interface [polypeptide binding]; other site
548476000421	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
548476000422	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
548476000423	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
548476000424	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
548476000425	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
548476000426	nudix motif; other site
548476000427	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
548476000428	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
548476000429	Predicted membrane protein [Function unknown]; Region: COG1511
548476000430	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
548476000431	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
548476000432	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
548476000433	Predicted membrane protein [Function unknown]; Region: COG1511
548476000434	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
548476000435	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
548476000436	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
548476000437	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
548476000438	TrkA-N domain; Region: TrkA_N; pfam02254
548476000439	Domain of unknown function (DUF202); Region: DUF202; cl09954
548476000440	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
548476000441	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
548476000442	transmembrane helices; other site
548476000443	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
548476000444	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
548476000445	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
548476000446	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
548476000447	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
548476000448	substrate binding sites [chemical binding]; other site
548476000449	prephenate dehydrogenase; Validated; Region: PRK06545
548476000450	prephenate dehydrogenase; Validated; Region: PRK08507
548476000451	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
548476000452	CsbD-like; Region: CsbD; pfam05532
548476000453	MMPL family; Region: MMPL; pfam03176
548476000454	MMPL family; Region: MMPL; pfam03176
548476000455	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
548476000456	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
548476000457	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
548476000458	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
548476000459	metal ion-dependent adhesion site (MIDAS); other site
548476000460	Tubulin like; Region: Tubulin_2; pfam13809
548476000461	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319
548476000462	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
548476000463	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
548476000464	active site
548476000465	HIGH motif; other site
548476000466	nucleotide binding site [chemical binding]; other site
548476000467	active site
548476000468	KMSKS motif; other site
548476000469	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
548476000470	Helix-turn-helix domain; Region: HTH_28; pfam13518
548476000471	MULE transposase domain; Region: MULE; pfam10551
548476000472	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
548476000473	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
548476000474	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548476000475	homodimer interface [polypeptide binding]; other site
548476000476	catalytic residue [active]
548476000477	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
548476000478	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
548476000479	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548476000480	Walker A motif; other site
548476000481	ATP binding site [chemical binding]; other site
548476000482	Walker B motif; other site
548476000483	arginine finger; other site
548476000484	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
548476000485	hypothetical protein; Validated; Region: PRK00153
548476000486	recombination protein RecR; Reviewed; Region: recR; PRK00076
548476000487	RecR protein; Region: RecR; pfam02132
548476000488	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
548476000489	putative active site [active]
548476000490	putative metal-binding site [ion binding]; other site
548476000491	tetramer interface [polypeptide binding]; other site
548476000492	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
548476000493	catalytic triad [active]
548476000494	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
548476000495	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
548476000496	DNA polymerase III subunit epsilon; Validated; Region: PRK05601
548476000497	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
548476000498	active site
548476000499	substrate binding site [chemical binding]; other site
548476000500	superantigen-like protein; Reviewed; Region: PRK13335
548476000501	2-isopropylmalate synthase; Validated; Region: PRK03739
548476000502	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
548476000503	active site
548476000504	catalytic residues [active]
548476000505	metal binding site [ion binding]; metal-binding site
548476000506	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
548476000507	Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188
548476000508	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
548476000509	aspartate kinase; Reviewed; Region: PRK06635
548476000510	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
548476000511	putative nucleotide binding site [chemical binding]; other site
548476000512	putative catalytic residues [active]
548476000513	putative Mg ion binding site [ion binding]; other site
548476000514	putative aspartate binding site [chemical binding]; other site
548476000515	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
548476000516	putative allosteric regulatory site; other site
548476000517	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
548476000518	putative allosteric regulatory residue; other site
548476000519	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
548476000520	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
548476000521	Cna protein B-type domain; Region: Cna_B; pfam05738
548476000522	Cna protein B-type domain; Region: Cna_B; pfam05738
548476000523	Cna protein B-type domain; Region: Cna_B; pfam05738
548476000524	Cna protein B-type domain; Region: Cna_B; pfam05738
548476000525	Cna protein B-type domain; Region: Cna_B; pfam05738
548476000526	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
548476000527	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
548476000528	active site
548476000529	catalytic site [active]
548476000530	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
548476000531	active site
548476000532	catalytic site [active]
548476000533	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
548476000534	Uncharacterized membrane protein [Function unknown]; Region: COG3949
548476000535	RNA polymerase sigma factor; Provisional; Region: PRK12535
548476000536	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
548476000537	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
548476000538	DNA binding residues [nucleotide binding]
548476000539	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
548476000540	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
548476000541	heme binding pocket [chemical binding]; other site
548476000542	Predicted membrane protein [Function unknown]; Region: COG1511
548476000543	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
548476000544	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
548476000545	MULE transposase domain; Region: MULE; pfam10551
548476000546	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
548476000547	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
548476000548	putative active site [active]
548476000549	putative metal binding site [ion binding]; other site
548476000550	Yqey-like protein; Region: YqeY; pfam09424
548476000551	Transglycosylase; Region: Transgly; pfam00912
548476000552	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
548476000553	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
548476000554	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
548476000555	Transcription factor WhiB; Region: Whib; pfam02467
548476000556	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
548476000557	homotrimer interaction site [polypeptide binding]; other site
548476000558	putative active site [active]
548476000559	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
548476000560	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
548476000561	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
548476000562	ligand binding site [chemical binding]; other site
548476000563	flexible hinge region; other site
548476000564	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
548476000565	putative switch regulator; other site
548476000566	non-specific DNA interactions [nucleotide binding]; other site
548476000567	DNA binding site [nucleotide binding]
548476000568	sequence specific DNA binding site [nucleotide binding]; other site
548476000569	putative cAMP binding site [chemical binding]; other site
548476000570	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
548476000571	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
548476000572	minor groove reading motif; other site
548476000573	helix-hairpin-helix signature motif; other site
548476000574	substrate binding pocket [chemical binding]; other site
548476000575	active site
548476000576	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
548476000577	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
548476000578	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
548476000579	catalytic residues [active]
548476000580	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
548476000581	putative active site [active]
548476000582	putative CoA binding site [chemical binding]; other site
548476000583	nudix motif; other site
548476000584	metal binding site [ion binding]; metal-binding site
548476000585	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
548476000586	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
548476000587	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
548476000588	active site
548476000589	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
548476000590	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
548476000591	Walker A/P-loop; other site
548476000592	ATP binding site [chemical binding]; other site
548476000593	Q-loop/lid; other site
548476000594	ABC transporter signature motif; other site
548476000595	Walker B; other site
548476000596	D-loop; other site
548476000597	H-loop/switch region; other site
548476000598	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
548476000599	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
548476000600	Walker A/P-loop; other site
548476000601	ATP binding site [chemical binding]; other site
548476000602	Q-loop/lid; other site
548476000603	ABC transporter signature motif; other site
548476000604	Walker B; other site
548476000605	D-loop; other site
548476000606	H-loop/switch region; other site
548476000607	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
548476000608	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
548476000609	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548476000610	dimer interface [polypeptide binding]; other site
548476000611	conserved gate region; other site
548476000612	putative PBP binding loops; other site
548476000613	ABC-ATPase subunit interface; other site
548476000614	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
548476000615	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548476000616	dimer interface [polypeptide binding]; other site
548476000617	conserved gate region; other site
548476000618	putative PBP binding loops; other site
548476000619	ABC-ATPase subunit interface; other site
548476000620	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
548476000621	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
548476000622	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
548476000623	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
548476000624	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
548476000625	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
548476000626	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
548476000627	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548476000628	motif II; other site
548476000629	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
548476000630	Type II/IV secretion system protein; Region: T2SE; pfam00437
548476000631	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
548476000632	ATP binding site [chemical binding]; other site
548476000633	Walker A motif; other site
548476000634	hexamer interface [polypeptide binding]; other site
548476000635	Walker B motif; other site
548476000636	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
548476000637	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
548476000638	helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816
548476000639	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
548476000640	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
548476000641	putative Mg++ binding site [ion binding]; other site
548476000642	helicase superfamily c-terminal domain; Region: HELICc; smart00490
548476000643	nucleotide binding region [chemical binding]; other site
548476000644	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
548476000645	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
548476000646	DNA-binding site [nucleotide binding]; DNA binding site
548476000647	RNA-binding motif; other site
548476000648	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
548476000649	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
548476000650	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
548476000651	DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051
548476000652	active site
548476000653	interdomain interaction site; other site
548476000654	putative metal-binding site [ion binding]; other site
548476000655	nucleotide binding site [chemical binding]; other site
548476000656	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
548476000657	domain I; other site
548476000658	phosphate binding site [ion binding]; other site
548476000659	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
548476000660	domain II; other site
548476000661	domain III; other site
548476000662	nucleotide binding site [chemical binding]; other site
548476000663	DNA binding groove [nucleotide binding]
548476000664	catalytic site [active]
548476000665	domain IV; other site
548476000666	Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754
548476000667	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
548476000668	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
548476000669	Predicted membrane protein [Function unknown]; Region: COG2311
548476000670	Protein of unknown function (DUF418); Region: DUF418; cl12135
548476000671	Protein of unknown function (DUF418); Region: DUF418; pfam04235
548476000672	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
548476000673	dimerization interface [polypeptide binding]; other site
548476000674	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
548476000675	cyclase homology domain; Region: CHD; cd07302
548476000676	nucleotidyl binding site; other site
548476000677	metal binding site [ion binding]; metal-binding site
548476000678	dimer interface [polypeptide binding]; other site
548476000679	DNA polymerase III subunit delta'; Validated; Region: PRK07940
548476000680	DNA polymerase III subunit delta'; Validated; Region: PRK08485
548476000681	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
548476000682	Protein of unknown function (DUF3644); Region: DUF3644; pfam12358
548476000683	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
548476000684	CoenzymeA binding site [chemical binding]; other site
548476000685	subunit interaction site [polypeptide binding]; other site
548476000686	PHB binding site; other site
548476000687	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
548476000688	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
548476000689	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
548476000690	active site
548476000691	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
548476000692	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
548476000693	active site
548476000694	trimer interface [polypeptide binding]; other site
548476000695	allosteric site; other site
548476000696	active site lid [active]
548476000697	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
548476000698	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
548476000699	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
548476000700	active site turn [active]
548476000701	phosphorylation site [posttranslational modification]
548476000702	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
548476000703	HPr interaction site; other site
548476000704	glycerol kinase (GK) interaction site [polypeptide binding]; other site
548476000705	active site
548476000706	phosphorylation site [posttranslational modification]
548476000707	acyl-CoA synthetase; Validated; Region: PRK07788
548476000708	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
548476000709	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
548476000710	acyl-activating enzyme (AAE) consensus motif; other site
548476000711	AMP binding site [chemical binding]; other site
548476000712	active site
548476000713	CoA binding site [chemical binding]; other site
548476000714	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
548476000715	active site
548476000716	catalytic triad [active]
548476000717	oxyanion hole [active]
548476000718	S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
548476000719	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
548476000720	NAD binding site [chemical binding]; other site
548476000721	catalytic Zn binding site [ion binding]; other site
548476000722	substrate binding site [chemical binding]; other site
548476000723	structural Zn binding site [ion binding]; other site
548476000724	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
548476000725	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
548476000726	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
548476000727	Thioredoxin; Region: Thioredoxin_4; pfam13462
548476000728	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
548476000729	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
548476000730	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
548476000731	substrate binding site; other site
548476000732	tetramer interface; other site
548476000733	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
548476000734	Divergent AAA domain; Region: AAA_4; pfam04326
548476000735	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
548476000736	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
548476000737	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
548476000738	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
548476000739	NADP binding site [chemical binding]; other site
548476000740	active site
548476000741	putative substrate binding site [chemical binding]; other site
548476000742	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
548476000743	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
548476000744	NAD binding site [chemical binding]; other site
548476000745	substrate binding site [chemical binding]; other site
548476000746	homodimer interface [polypeptide binding]; other site
548476000747	active site
548476000748	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
548476000749	Zn binding site [ion binding]; other site
548476000750	Putative esterase; Region: Esterase; pfam00756
548476000751	Predicted esterase [General function prediction only]; Region: COG0627
548476000752	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
548476000753	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
548476000754	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
548476000755	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
548476000756	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
548476000757	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
548476000758	non-specific DNA binding site [nucleotide binding]; other site
548476000759	salt bridge; other site
548476000760	sequence-specific DNA binding site [nucleotide binding]; other site
548476000761	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
548476000762	Domain of unknown function (DUF955); Region: DUF955; pfam06114
548476000763	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
548476000764	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
548476000765	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
548476000766	putative Iron-sulfur protein interface [polypeptide binding]; other site
548476000767	proximal heme binding site [chemical binding]; other site
548476000768	distal heme binding site [chemical binding]; other site
548476000769	putative dimer interface [polypeptide binding]; other site
548476000770	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
548476000771	L-aspartate oxidase; Provisional; Region: PRK06175
548476000772	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
548476000773	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
548476000774	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
548476000775	4Fe-4S binding domain; Region: Fer4; pfam00037
548476000776	T5orf172 domain; Region: T5orf172; pfam10544
548476000777	DEAD-like helicases superfamily; Region: DEXDc; smart00487
548476000778	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
548476000779	ATP binding site [chemical binding]; other site
548476000780	putative Mg++ binding site [ion binding]; other site
548476000781	putative transposase OrfB; Reviewed; Region: PHA02517
548476000782	HTH-like domain; Region: HTH_21; pfam13276
548476000783	Integrase core domain; Region: rve; pfam00665
548476000784	Integrase core domain; Region: rve_3; pfam13683
548476000785	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548476000786	Transposase; Region: HTH_Tnp_1; pfam01527
548476000787	Methyltransferase domain; Region: Methyltransf_26; pfam13659
548476000788	Predicted membrane protein [Function unknown]; Region: COG2733
548476000789	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
548476000790	Class I aldolases; Region: Aldolase_Class_I; cl17187
548476000791	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
548476000792	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
548476000793	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
548476000794	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
548476000795	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
548476000796	S-ribosylhomocysteinase; Provisional; Region: PRK02260
548476000797	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
548476000798	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
548476000799	active site
548476000800	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
548476000801	hypothetical protein; Reviewed; Region: PRK09588
548476000802	Fic family protein [Function unknown]; Region: COG3177
548476000803	Fic/DOC family; Region: Fic; pfam02661
548476000804	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
548476000805	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
548476000806	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
548476000807	phosphate binding site [ion binding]; other site
548476000808	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
548476000809	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
548476000810	active site 2 [active]
548476000811	active site 1 [active]
548476000812	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
548476000813	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
548476000814	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
548476000815	putative NAD(P) binding site [chemical binding]; other site
548476000816	active site
548476000817	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
548476000818	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
548476000819	active site
548476000820	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605
548476000821	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
548476000822	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
548476000823	acyl-activating enzyme (AAE) consensus motif; other site
548476000824	AMP binding site [chemical binding]; other site
548476000825	active site
548476000826	CoA binding site [chemical binding]; other site
548476000827	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605
548476000828	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
548476000829	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
548476000830	acyl-activating enzyme (AAE) consensus motif; other site
548476000831	AMP binding site [chemical binding]; other site
548476000832	active site
548476000833	CoA binding site [chemical binding]; other site
548476000834	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
548476000835	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
548476000836	putative ADP-binding pocket [chemical binding]; other site
548476000837	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
548476000838	catalytic core [active]
548476000839	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
548476000840	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
548476000841	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
548476000842	dimer interface [polypeptide binding]; other site
548476000843	phosphorylation site [posttranslational modification]
548476000844	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548476000845	ATP binding site [chemical binding]; other site
548476000846	Mg2+ binding site [ion binding]; other site
548476000847	G-X-G motif; other site
548476000848	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
548476000849	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548476000850	active site
548476000851	phosphorylation site [posttranslational modification]
548476000852	intermolecular recognition site; other site
548476000853	dimerization interface [polypeptide binding]; other site
548476000854	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
548476000855	DNA binding site [nucleotide binding]
548476000856	exopolyphosphatase; Region: exo_poly_only; TIGR03706
548476000857	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
548476000858	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
548476000859	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
548476000860	DNA binding domain, excisionase family; Region: excise; TIGR01764
548476000861	PemK-like protein; Region: PemK; cl00995
548476000862	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
548476000863	active site
548476000864	Tubby C 2; Region: Tub_2; cl02043
548476000865	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
548476000866	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548476000867	motif II; other site
548476000868	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
548476000869	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
548476000870	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
548476000871	tRNA; other site
548476000872	putative tRNA binding site [nucleotide binding]; other site
548476000873	putative NADP binding site [chemical binding]; other site
548476000874	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
548476000875	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
548476000876	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
548476000877	domain interfaces; other site
548476000878	active site
548476000879	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
548476000880	active site
548476000881	homodimer interface [polypeptide binding]; other site
548476000882	SAM binding site [chemical binding]; other site
548476000883	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
548476000884	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
548476000885	active site
548476000886	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
548476000887	dimer interface [polypeptide binding]; other site
548476000888	active site
548476000889	Schiff base residues; other site
548476000890	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
548476000891	substrate binding site [chemical binding]; other site
548476000892	active site
548476000893	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
548476000894	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
548476000895	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
548476000896	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
548476000897	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
548476000898	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548476000899	Walker A/P-loop; other site
548476000900	ATP binding site [chemical binding]; other site
548476000901	ABC transporter signature motif; other site
548476000902	Walker B; other site
548476000903	D-loop; other site
548476000904	H-loop/switch region; other site
548476000905	ABC transporter; Region: ABC_tran_2; pfam12848
548476000906	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
548476000907	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
548476000908	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548476000909	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
548476000910	Walker A/P-loop; other site
548476000911	ATP binding site [chemical binding]; other site
548476000912	Q-loop/lid; other site
548476000913	ABC transporter signature motif; other site
548476000914	Walker B; other site
548476000915	D-loop; other site
548476000916	H-loop/switch region; other site
548476000917	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
548476000918	FIC domain binding interface [polypeptide binding]; other site
548476000919	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
548476000920	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
548476000921	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
548476000922	LGFP repeat; Region: LGFP; pfam08310
548476000923	LGFP repeat; Region: LGFP; pfam08310
548476000924	LGFP repeat; Region: LGFP; pfam08310
548476000925	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
548476000926	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
548476000927	Presynaptic Site I dimer interface [polypeptide binding]; other site
548476000928	catalytic residues [active]
548476000929	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
548476000930	Synaptic Flat tetramer interface [polypeptide binding]; other site
548476000931	Synaptic Site I dimer interface [polypeptide binding]; other site
548476000932	DNA binding site [nucleotide binding]
548476000933	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
548476000934	DNA-binding interface [nucleotide binding]; DNA binding site
548476000935	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
548476000936	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
548476000937	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
548476000938	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
548476000939	FtsX-like permease family; Region: FtsX; pfam02687
548476000940	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
548476000941	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
548476000942	Walker A/P-loop; other site
548476000943	ATP binding site [chemical binding]; other site
548476000944	Q-loop/lid; other site
548476000945	ABC transporter signature motif; other site
548476000946	Walker B; other site
548476000947	D-loop; other site
548476000948	H-loop/switch region; other site
548476000949	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
548476000950	HlyD family secretion protein; Region: HlyD_3; pfam13437
548476000951	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
548476000952	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
548476000953	inhibitor-cofactor binding pocket; inhibition site
548476000954	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548476000955	catalytic residue [active]
548476000956	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
548476000957	catalytic core [active]
548476000958	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
548476000959	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
548476000960	catalytic residues [active]
548476000961	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
548476000962	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
548476000963	ResB-like family; Region: ResB; pfam05140
548476000964	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
548476000965	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
548476000966	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
548476000967	non-specific DNA binding site [nucleotide binding]; other site
548476000968	salt bridge; other site
548476000969	sequence-specific DNA binding site [nucleotide binding]; other site
548476000970	Protein of unknown function (DUF4229); Region: DUF4229; pfam14012
548476000971	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
548476000972	UbiA prenyltransferase family; Region: UbiA; pfam01040
548476000973	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
548476000974	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
548476000975	ABC-ATPase subunit  interface; other site
548476000976	dimer interface [polypeptide binding]; other site
548476000977	putative PBP binding regions; other site
548476000978	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
548476000979	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
548476000980	ABC-ATPase subunit  interface; other site
548476000981	dimer interface [polypeptide binding]; other site
548476000982	putative PBP binding regions; other site
548476000983	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
548476000984	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
548476000985	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
548476000986	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
548476000987	intersubunit interface [polypeptide binding]; other site
548476000988	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
548476000989	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
548476000990	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
548476000991	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
548476000992	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
548476000993	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
548476000994	acyl-activating enzyme (AAE) consensus motif; other site
548476000995	AMP binding site [chemical binding]; other site
548476000996	active site
548476000997	CoA binding site [chemical binding]; other site
548476000998	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
548476000999	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
548476001000	substrate binding site [chemical binding]; other site
548476001001	oxyanion hole (OAH) forming residues; other site
548476001002	trimer interface [polypeptide binding]; other site
548476001003	putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208
548476001004	oligomer interface [polypeptide binding]; other site
548476001005	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
548476001006	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322
548476001007	O-succinylbenzoate synthase; Provisional; Region: PRK02901
548476001008	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
548476001009	active site
548476001010	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548476001011	Walker A/P-loop; other site
548476001012	ATP binding site [chemical binding]; other site
548476001013	Q-loop/lid; other site
548476001014	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548476001015	ABC transporter signature motif; other site
548476001016	Walker B; other site
548476001017	D-loop; other site
548476001018	H-loop/switch region; other site
548476001019	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548476001020	AAA domain; Region: AAA_21; pfam13304
548476001021	Walker A/P-loop; other site
548476001022	ATP binding site [chemical binding]; other site
548476001023	Q-loop/lid; other site
548476001024	ABC transporter signature motif; other site
548476001025	Walker B; other site
548476001026	D-loop; other site
548476001027	H-loop/switch region; other site
548476001028	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
548476001029	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
548476001030	dimer interface [polypeptide binding]; other site
548476001031	tetramer interface [polypeptide binding]; other site
548476001032	PYR/PP interface [polypeptide binding]; other site
548476001033	TPP binding site [chemical binding]; other site
548476001034	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
548476001035	TPP-binding site; other site
548476001036	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
548476001037	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
548476001038	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
548476001039	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
548476001040	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548476001041	S-adenosylmethionine binding site [chemical binding]; other site
548476001042	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
548476001043	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
548476001044	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
548476001045	substrate binding pocket [chemical binding]; other site
548476001046	chain length determination region; other site
548476001047	substrate-Mg2+ binding site; other site
548476001048	catalytic residues [active]
548476001049	aspartate-rich region 1; other site
548476001050	active site lid residues [active]
548476001051	aspartate-rich region 2; other site
548476001052	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
548476001053	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
548476001054	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
548476001055	putative dimer interface [polypeptide binding]; other site
548476001056	N-terminal domain interface [polypeptide binding]; other site
548476001057	putative substrate binding pocket (H-site) [chemical binding]; other site
548476001058	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
548476001059	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
548476001060	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
548476001061	putative homodimer interface [polypeptide binding]; other site
548476001062	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
548476001063	heterodimer interface [polypeptide binding]; other site
548476001064	homodimer interface [polypeptide binding]; other site
548476001065	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
548476001066	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
548476001067	23S rRNA interface [nucleotide binding]; other site
548476001068	L7/L12 interface [polypeptide binding]; other site
548476001069	putative thiostrepton binding site; other site
548476001070	L25 interface [polypeptide binding]; other site
548476001071	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
548476001072	mRNA/rRNA interface [nucleotide binding]; other site
548476001073	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
548476001074	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
548476001075	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
548476001076	catalytic residue [active]
548476001077	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
548476001078	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
548476001079	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
548476001080	dimer interface [polypeptide binding]; other site
548476001081	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548476001082	catalytic residue [active]
548476001083	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
548476001084	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
548476001085	FAD binding pocket [chemical binding]; other site
548476001086	FAD binding motif [chemical binding]; other site
548476001087	phosphate binding motif [ion binding]; other site
548476001088	NAD binding pocket [chemical binding]; other site
548476001089	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
548476001090	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
548476001091	intersubunit interface [polypeptide binding]; other site
548476001092	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
548476001093	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
548476001094	ABC-ATPase subunit  interface; other site
548476001095	dimer interface [polypeptide binding]; other site
548476001096	putative PBP binding regions; other site
548476001097	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
548476001098	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
548476001099	ABC-ATPase subunit  interface; other site
548476001100	dimer interface [polypeptide binding]; other site
548476001101	putative PBP binding regions; other site
548476001102	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
548476001103	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
548476001104	Walker A/P-loop; other site
548476001105	ATP binding site [chemical binding]; other site
548476001106	Q-loop/lid; other site
548476001107	ABC transporter signature motif; other site
548476001108	Walker B; other site
548476001109	D-loop; other site
548476001110	H-loop/switch region; other site
548476001111	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
548476001112	23S rRNA interface [nucleotide binding]; other site
548476001113	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
548476001114	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
548476001115	L11 interface [polypeptide binding]; other site
548476001116	putative EF-Tu interaction site [polypeptide binding]; other site
548476001117	putative EF-G interaction site [polypeptide binding]; other site
548476001118	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
548476001119	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
548476001120	sequence-specific DNA binding site [nucleotide binding]; other site
548476001121	salt bridge; other site
548476001122	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
548476001123	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
548476001124	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
548476001125	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
548476001126	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
548476001127	RPB1 interaction site [polypeptide binding]; other site
548476001128	RPB10 interaction site [polypeptide binding]; other site
548476001129	RPB11 interaction site [polypeptide binding]; other site
548476001130	RPB3 interaction site [polypeptide binding]; other site
548476001131	RPB12 interaction site [polypeptide binding]; other site
548476001132	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
548476001133	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
548476001134	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
548476001135	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
548476001136	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
548476001137	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
548476001138	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
548476001139	G-loop; other site
548476001140	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
548476001141	DNA binding site [nucleotide binding]
548476001142	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
548476001143	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943
548476001144	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943
548476001145	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
548476001146	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
548476001147	Walker A/P-loop; other site
548476001148	ATP binding site [chemical binding]; other site
548476001149	Q-loop/lid; other site
548476001150	ABC transporter signature motif; other site
548476001151	Walker B; other site
548476001152	D-loop; other site
548476001153	H-loop/switch region; other site
548476001154	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
548476001155	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
548476001156	Walker A/P-loop; other site
548476001157	ATP binding site [chemical binding]; other site
548476001158	Q-loop/lid; other site
548476001159	ABC transporter signature motif; other site
548476001160	Walker B; other site
548476001161	D-loop; other site
548476001162	H-loop/switch region; other site
548476001163	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
548476001164	hypothetical protein; Provisional; Region: PRK06547
548476001165	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
548476001166	S17 interaction site [polypeptide binding]; other site
548476001167	S8 interaction site; other site
548476001168	16S rRNA interaction site [nucleotide binding]; other site
548476001169	streptomycin interaction site [chemical binding]; other site
548476001170	23S rRNA interaction site [nucleotide binding]; other site
548476001171	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
548476001172	30S ribosomal protein S7; Validated; Region: PRK05302
548476001173	elongation factor G; Reviewed; Region: PRK00007
548476001174	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
548476001175	G1 box; other site
548476001176	putative GEF interaction site [polypeptide binding]; other site
548476001177	GTP/Mg2+ binding site [chemical binding]; other site
548476001178	Switch I region; other site
548476001179	G2 box; other site
548476001180	G3 box; other site
548476001181	Switch II region; other site
548476001182	G4 box; other site
548476001183	G5 box; other site
548476001184	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
548476001185	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
548476001186	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
548476001187	elongation factor Tu; Reviewed; Region: PRK00049
548476001188	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
548476001189	G1 box; other site
548476001190	GEF interaction site [polypeptide binding]; other site
548476001191	GTP/Mg2+ binding site [chemical binding]; other site
548476001192	Switch I region; other site
548476001193	G2 box; other site
548476001194	G3 box; other site
548476001195	Switch II region; other site
548476001196	G4 box; other site
548476001197	G5 box; other site
548476001198	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
548476001199	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
548476001200	Antibiotic Binding Site [chemical binding]; other site
548476001201	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
548476001202	active site
548476001203	Asp23 family; Region: Asp23; pfam03780
548476001204	Asp23 family; Region: Asp23; pfam03780
548476001205	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
548476001206	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
548476001207	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
548476001208	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
548476001209	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
548476001210	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
548476001211	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
548476001212	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
548476001213	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
548476001214	putative translocon binding site; other site
548476001215	protein-rRNA interface [nucleotide binding]; other site
548476001216	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
548476001217	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
548476001218	G-X-X-G motif; other site
548476001219	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
548476001220	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
548476001221	23S rRNA interface [nucleotide binding]; other site
548476001222	5S rRNA interface [nucleotide binding]; other site
548476001223	putative antibiotic binding site [chemical binding]; other site
548476001224	L25 interface [polypeptide binding]; other site
548476001225	L27 interface [polypeptide binding]; other site
548476001226	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
548476001227	putative translocon interaction site; other site
548476001228	23S rRNA interface [nucleotide binding]; other site
548476001229	signal recognition particle (SRP54) interaction site; other site
548476001230	L23 interface [polypeptide binding]; other site
548476001231	trigger factor interaction site; other site
548476001232	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
548476001233	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
548476001234	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
548476001235	putative substrate binding site [chemical binding]; other site
548476001236	putative ATP binding site [chemical binding]; other site
548476001237	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
548476001238	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
548476001239	substrate binding [chemical binding]; other site
548476001240	active site
548476001241	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
548476001242	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
548476001243	active site turn [active]
548476001244	phosphorylation site [posttranslational modification]
548476001245	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
548476001246	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
548476001247	HPr interaction site; other site
548476001248	glycerol kinase (GK) interaction site [polypeptide binding]; other site
548476001249	active site
548476001250	phosphorylation site [posttranslational modification]
548476001251	Dynamin family; Region: Dynamin_N; pfam00350
548476001252	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
548476001253	G1 box; other site
548476001254	GTP/Mg2+ binding site [chemical binding]; other site
548476001255	G2 box; other site
548476001256	Switch I region; other site
548476001257	G3 box; other site
548476001258	Switch II region; other site
548476001259	G4 box; other site
548476001260	G5 box; other site
548476001261	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
548476001262	G1 box; other site
548476001263	GTP/Mg2+ binding site [chemical binding]; other site
548476001264	G2 box; other site
548476001265	Switch I region; other site
548476001266	G3 box; other site
548476001267	Switch II region; other site
548476001268	G4 box; other site
548476001269	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
548476001270	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
548476001271	active site
548476001272	nucleotide binding site [chemical binding]; other site
548476001273	HIGH motif; other site
548476001274	KMSKS motif; other site
548476001275	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
548476001276	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
548476001277	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
548476001278	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
548476001279	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
548476001280	active site
548476001281	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
548476001282	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
548476001283	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
548476001284	Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085
548476001285	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270
548476001286	Bacterial sugar transferase; Region: Bac_transf; pfam02397
548476001287	putative transposase OrfB; Reviewed; Region: PHA02517
548476001288	HTH-like domain; Region: HTH_21; pfam13276
548476001289	Integrase core domain; Region: rve; pfam00665
548476001290	Integrase core domain; Region: rve_3; pfam13683
548476001291	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548476001292	Transposase; Region: HTH_Tnp_1; cl17663
548476001293	MULE transposase domain; Region: MULE; pfam10551
548476001294	Integrase core domain; Region: rve; pfam00665
548476001295	Integrase core domain; Region: rve_3; pfam13683
548476001296	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
548476001297	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
548476001298	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
548476001299	RNA binding site [nucleotide binding]; other site
548476001300	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
548476001301	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
548476001302	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
548476001303	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
548476001304	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
548476001305	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
548476001306	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
548476001307	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
548476001308	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
548476001309	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
548476001310	5S rRNA interface [nucleotide binding]; other site
548476001311	L27 interface [polypeptide binding]; other site
548476001312	23S rRNA interface [nucleotide binding]; other site
548476001313	L5 interface [polypeptide binding]; other site
548476001314	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
548476001315	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
548476001316	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
548476001317	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
548476001318	23S rRNA binding site [nucleotide binding]; other site
548476001319	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
548476001320	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
548476001321	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548476001322	S-adenosylmethionine binding site [chemical binding]; other site
548476001323	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
548476001324	SecY translocase; Region: SecY; pfam00344
548476001325	adenylate kinase; Reviewed; Region: adk; PRK00279
548476001326	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
548476001327	AMP-binding site [chemical binding]; other site
548476001328	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
548476001329	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
548476001330	active site
548476001331	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
548476001332	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
548476001333	rRNA binding site [nucleotide binding]; other site
548476001334	predicted 30S ribosome binding site; other site
548476001335	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
548476001336	30S ribosomal protein S13; Region: bact_S13; TIGR03631
548476001337	30S ribosomal protein S11; Validated; Region: PRK05309
548476001338	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
548476001339	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
548476001340	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
548476001341	RNA binding surface [nucleotide binding]; other site
548476001342	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
548476001343	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
548476001344	alphaNTD - beta interaction site [polypeptide binding]; other site
548476001345	alphaNTD homodimer interface [polypeptide binding]; other site
548476001346	alphaNTD - beta' interaction site [polypeptide binding]; other site
548476001347	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
548476001348	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
548476001349	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
548476001350	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
548476001351	dimerization interface 3.5A [polypeptide binding]; other site
548476001352	active site
548476001353	type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919
548476001354	Subtilase family; Region: Peptidase_S8; pfam00082
548476001355	active site
548476001356	catalytic residues [active]
548476001357	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
548476001358	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
548476001359	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
548476001360	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
548476001361	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
548476001362	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
548476001363	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
548476001364	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
548476001365	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
548476001366	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
548476001367	23S rRNA interface [nucleotide binding]; other site
548476001368	L3 interface [polypeptide binding]; other site
548476001369	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
548476001370	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
548476001371	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
548476001372	active site
548476001373	substrate binding site [chemical binding]; other site
548476001374	metal binding site [ion binding]; metal-binding site
548476001375	ribonuclease E; Reviewed; Region: rne; PRK10811
548476001376	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
548476001377	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
548476001378	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
548476001379	glutaminase active site [active]
548476001380	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
548476001381	dimer interface [polypeptide binding]; other site
548476001382	active site
548476001383	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
548476001384	dimer interface [polypeptide binding]; other site
548476001385	active site
548476001386	alanine racemase; Reviewed; Region: alr; PRK00053
548476001387	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
548476001388	active site
548476001389	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
548476001390	dimer interface [polypeptide binding]; other site
548476001391	substrate binding site [chemical binding]; other site
548476001392	catalytic residues [active]
548476001393	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
548476001394	Predicted permease [General function prediction only]; Region: COG2985
548476001395	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
548476001396	TrkA-C domain; Region: TrkA_C; pfam02080
548476001397	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
548476001398	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
548476001399	Glycoprotease family; Region: Peptidase_M22; pfam00814
548476001400	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
548476001401	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
548476001402	Coenzyme A binding pocket [chemical binding]; other site
548476001403	UGMP family protein; Validated; Region: PRK09604
548476001404	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
548476001405	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548476001406	active site
548476001407	phosphorylation site [posttranslational modification]
548476001408	intermolecular recognition site; other site
548476001409	dimerization interface [polypeptide binding]; other site
548476001410	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
548476001411	DNA binding residues [nucleotide binding]
548476001412	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
548476001413	Mg2+ binding site [ion binding]; other site
548476001414	G-X-G motif; other site
548476001415	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
548476001416	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
548476001417	Walker A/P-loop; other site
548476001418	ATP binding site [chemical binding]; other site
548476001419	Q-loop/lid; other site
548476001420	ABC transporter signature motif; other site
548476001421	Walker B; other site
548476001422	D-loop; other site
548476001423	H-loop/switch region; other site
548476001424	FtsX-like permease family; Region: FtsX; pfam02687
548476001425	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
548476001426	oligomerisation interface [polypeptide binding]; other site
548476001427	mobile loop; other site
548476001428	roof hairpin; other site
548476001429	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
548476001430	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
548476001431	ring oligomerisation interface [polypeptide binding]; other site
548476001432	ATP/Mg binding site [chemical binding]; other site
548476001433	stacking interactions; other site
548476001434	hinge regions; other site
548476001435	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548476001436	ABC transporter signature motif; other site
548476001437	Walker B; other site
548476001438	D-loop; other site
548476001439	H-loop/switch region; other site
548476001440	Transcription factor WhiB; Region: Whib; pfam02467
548476001441	RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
548476001442	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
548476001443	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
548476001444	DNA binding residues [nucleotide binding]
548476001445	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
548476001446	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
548476001447	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
548476001448	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
548476001449	active site
548476001450	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
548476001451	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
548476001452	phosphate binding site [ion binding]; other site
548476001453	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
548476001454	EamA-like transporter family; Region: EamA; pfam00892
548476001455	Transcriptional regulator [Transcription]; Region: LysR; COG0583
548476001456	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
548476001457	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
548476001458	putative dimerization interface [polypeptide binding]; other site
548476001459	GMP synthase; Reviewed; Region: guaA; PRK00074
548476001460	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
548476001461	AMP/PPi binding site [chemical binding]; other site
548476001462	candidate oxyanion hole; other site
548476001463	catalytic triad [active]
548476001464	potential glutamine specificity residues [chemical binding]; other site
548476001465	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
548476001466	ATP Binding subdomain [chemical binding]; other site
548476001467	Ligand Binding sites [chemical binding]; other site
548476001468	Dimerization subdomain; other site
548476001469	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
548476001470	active site
548476001471	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
548476001472	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
548476001473	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
548476001474	catalytic residue [active]
548476001475	PspC domain; Region: PspC; cl00864
548476001476	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
548476001477	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
548476001478	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548476001479	ATP binding site [chemical binding]; other site
548476001480	Mg2+ binding site [ion binding]; other site
548476001481	G-X-G motif; other site
548476001482	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
548476001483	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548476001484	active site
548476001485	phosphorylation site [posttranslational modification]
548476001486	intermolecular recognition site; other site
548476001487	dimerization interface [polypeptide binding]; other site
548476001488	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
548476001489	dimerization interface [polypeptide binding]; other site
548476001490	DNA binding residues [nucleotide binding]
548476001491	DNA Polymerase Y-family; Region: PolY_like; cd03468
548476001492	DNA binding site [nucleotide binding]
548476001493	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
548476001494	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
548476001495	putative dimer interface [polypeptide binding]; other site
548476001496	putative [2Fe-2S] cluster binding site [ion binding]; other site
548476001497	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548476001498	dimer interface [polypeptide binding]; other site
548476001499	conserved gate region; other site
548476001500	ABC-ATPase subunit interface; other site
548476001501	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
548476001502	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
548476001503	Walker A/P-loop; other site
548476001504	ATP binding site [chemical binding]; other site
548476001505	Q-loop/lid; other site
548476001506	ABC transporter signature motif; other site
548476001507	Walker B; other site
548476001508	D-loop; other site
548476001509	H-loop/switch region; other site
548476001510	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
548476001511	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
548476001512	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
548476001513	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
548476001514	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
548476001515	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
548476001516	active site
548476001517	PHP Thumb interface [polypeptide binding]; other site
548476001518	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
548476001519	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
548476001520	generic binding surface II; other site
548476001521	generic binding surface I; other site
548476001522	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
548476001523	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
548476001524	salt bridge; other site
548476001525	non-specific DNA binding site [nucleotide binding]; other site
548476001526	sequence-specific DNA binding site [nucleotide binding]; other site
548476001527	Uncharacterized conserved protein [Function unknown]; Region: COG3402
548476001528	Predicted membrane protein [Function unknown]; Region: COG3428
548476001529	Bacterial PH domain; Region: DUF304; pfam03703
548476001530	Bacterial PH domain; Region: DUF304; pfam03703
548476001531	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
548476001532	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
548476001533	GTP/Mg2+ binding site [chemical binding]; other site
548476001534	G1 box; other site
548476001535	G2 box; other site
548476001536	Switch I region; other site
548476001537	G3 box; other site
548476001538	Switch II region; other site
548476001539	G4 box; other site
548476001540	G5 box; other site
548476001541	Nucleoside recognition; Region: Gate; pfam07670
548476001542	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
548476001543	pyruvate kinase; Provisional; Region: PRK14725
548476001544	domain interfaces; other site
548476001545	active site
548476001546	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
548476001547	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
548476001548	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
548476001549	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
548476001550	homodimer interface [polypeptide binding]; other site
548476001551	NADP binding site [chemical binding]; other site
548476001552	substrate binding site [chemical binding]; other site
548476001553	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
548476001554	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
548476001555	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
548476001556	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613
548476001557	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
548476001558	homodimer interface [polypeptide binding]; other site
548476001559	substrate-cofactor binding pocket; other site
548476001560	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548476001561	catalytic residue [active]
548476001562	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
548476001563	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
548476001564	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
548476001565	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
548476001566	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
548476001567	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
548476001568	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
548476001569	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
548476001570	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
548476001571	DNA binding residues [nucleotide binding]
548476001572	Anti-sigma-K factor rskA; Region: RskA; pfam10099
548476001573	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
548476001574	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
548476001575	DNA-binding site [nucleotide binding]; DNA binding site
548476001576	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
548476001577	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548476001578	homodimer interface [polypeptide binding]; other site
548476001579	catalytic residue [active]
548476001580	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
548476001581	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
548476001582	active site
548476001583	multimer interface [polypeptide binding]; other site
548476001584	glutamine amidotransferase subunit PdxT; Provisional; Region: PRK13525
548476001585	conserved cys residue [active]
548476001586	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
548476001587	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
548476001588	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
548476001589	active site
548476001590	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
548476001591	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
548476001592	active site
548476001593	Zn binding site [ion binding]; other site
548476001594	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
548476001595	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
548476001596	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
548476001597	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
548476001598	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
548476001599	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
548476001600	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548476001601	putative substrate translocation pore; other site
548476001602	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
548476001603	putative catalytic site [active]
548476001604	putative metal binding site [ion binding]; other site
548476001605	putative phosphate binding site [ion binding]; other site
548476001606	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
548476001607	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
548476001608	active site
548476001609	HIGH motif; other site
548476001610	dimer interface [polypeptide binding]; other site
548476001611	KMSKS motif; other site
548476001612	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
548476001613	RDD family; Region: RDD; pfam06271
548476001614	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
548476001615	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
548476001616	NlpC/P60 family; Region: NLPC_P60; pfam00877
548476001617	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
548476001618	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
548476001619	active site
548476001620	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
548476001621	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
548476001622	metal binding site [ion binding]; metal-binding site
548476001623	putative dimer interface [polypeptide binding]; other site
548476001624	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
548476001625	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
548476001626	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
548476001627	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
548476001628	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
548476001629	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
548476001630	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
548476001631	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
548476001632	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
548476001633	non-specific DNA binding site [nucleotide binding]; other site
548476001634	salt bridge; other site
548476001635	sequence-specific DNA binding site [nucleotide binding]; other site
548476001636	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
548476001637	Domain of unknown function (DUF955); Region: DUF955; cl01076
548476001638	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
548476001639	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
548476001640	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
548476001641	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
548476001642	tetramer interface [polypeptide binding]; other site
548476001643	active site
548476001644	Mg2+/Mn2+ binding site [ion binding]; other site
548476001645	citrate synthase; Provisional; Region: PRK14033
548476001646	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
548476001647	oxalacetate binding site [chemical binding]; other site
548476001648	citrylCoA binding site [chemical binding]; other site
548476001649	coenzyme A binding site [chemical binding]; other site
548476001650	catalytic triad [active]
548476001651	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
548476001652	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
548476001653	Walker A/P-loop; other site
548476001654	ATP binding site [chemical binding]; other site
548476001655	Q-loop/lid; other site
548476001656	ABC transporter signature motif; other site
548476001657	Walker B; other site
548476001658	D-loop; other site
548476001659	H-loop/switch region; other site
548476001660	Transposase, Mutator family; Region: Transposase_mut; pfam00872
548476001661	MULE transposase domain; Region: MULE; pfam10551
548476001662	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
548476001663	Short C-terminal domain; Region: SHOCT; pfam09851
548476001664	Transposase; Region: DEDD_Tnp_IS110; pfam01548
548476001665	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
548476001666	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
548476001667	pyruvate carboxylase; Reviewed; Region: PRK12999
548476001668	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
548476001669	ATP-grasp domain; Region: ATP-grasp_4; cl17255
548476001670	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
548476001671	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
548476001672	active site
548476001673	catalytic residues [active]
548476001674	metal binding site [ion binding]; metal-binding site
548476001675	homodimer binding site [polypeptide binding]; other site
548476001676	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
548476001677	carboxyltransferase (CT) interaction site; other site
548476001678	biotinylation site [posttranslational modification]; other site
548476001679	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
548476001680	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
548476001681	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
548476001682	Integrase core domain; Region: rve; pfam00665
548476001683	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
548476001684	Abi-like protein; Region: Abi_2; pfam07751
548476001685	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
548476001686	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
548476001687	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
548476001688	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
548476001689	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
548476001690	carboxyltransferase (CT) interaction site; other site
548476001691	biotinylation site [posttranslational modification]; other site
548476001692	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
548476001693	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
548476001694	active site residue [active]
548476001695	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
548476001696	active site residue [active]
548476001697	ATP-grasp domain; Region: ATP-grasp_4; cl17255
548476001698	Domain of unknown function (DUF4282); Region: DUF4282; pfam14110
548476001699	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
548476001700	Maf-like protein; Region: Maf; pfam02545
548476001701	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
548476001702	active site
548476001703	dimer interface [polypeptide binding]; other site
548476001704	Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822
548476001705	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
548476001706	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
548476001707	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
548476001708	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
548476001709	trehalose synthase; Region: treS_nterm; TIGR02456
548476001710	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
548476001711	active site
548476001712	catalytic site [active]
548476001713	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
548476001714	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548476001715	dimer interface [polypeptide binding]; other site
548476001716	conserved gate region; other site
548476001717	putative PBP binding loops; other site
548476001718	ABC-ATPase subunit interface; other site
548476001719	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548476001720	dimer interface [polypeptide binding]; other site
548476001721	conserved gate region; other site
548476001722	putative PBP binding loops; other site
548476001723	ABC-ATPase subunit interface; other site
548476001724	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
548476001725	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
548476001726	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
548476001727	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
548476001728	Walker A/P-loop; other site
548476001729	ATP binding site [chemical binding]; other site
548476001730	Q-loop/lid; other site
548476001731	ABC transporter signature motif; other site
548476001732	Walker B; other site
548476001733	D-loop; other site
548476001734	H-loop/switch region; other site
548476001735	TOBE domain; Region: TOBE_2; pfam08402
548476001736	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
548476001737	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
548476001738	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
548476001739	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
548476001740	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
548476001741	ATP-grasp domain; Region: ATP-grasp; pfam02222
548476001742	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
548476001743	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
548476001744	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
548476001745	substrate binding site [chemical binding]; other site
548476001746	dimer interface [polypeptide binding]; other site
548476001747	ATP binding site [chemical binding]; other site
548476001748	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
548476001749	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
548476001750	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
548476001751	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
548476001752	DNA binding residues [nucleotide binding]
548476001753	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
548476001754	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
548476001755	acyl-coenzyme A oxidase; Region: PLN02526
548476001756	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
548476001757	active site
548476001758	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
548476001759	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; cl16254
548476001760	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
548476001761	putative active site [active]
548476001762	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
548476001763	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
548476001764	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
548476001765	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
548476001766	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
548476001767	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
548476001768	substrate binding site [chemical binding]; other site
548476001769	oxyanion hole (OAH) forming residues; other site
548476001770	trimer interface [polypeptide binding]; other site
548476001771	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
548476001772	active site
548476001773	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
548476001774	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
548476001775	hypothetical protein; Provisional; Region: PRK05463
548476001776	Transcriptional regulators [Transcription]; Region: GntR; COG1802
548476001777	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
548476001778	DNA-binding site [nucleotide binding]; DNA binding site
548476001779	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
548476001780	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
548476001781	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
548476001782	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
548476001783	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
548476001784	carboxyltransferase (CT) interaction site; other site
548476001785	biotinylation site [posttranslational modification]; other site
548476001786	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
548476001787	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
548476001788	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
548476001789	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
548476001790	putative active site [active]
548476001791	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
548476001792	active site
548476001793	catalytic site [active]
548476001794	Protein of unknown function (DUF2891); Region: DUF2891; pfam11199
548476001795	Region found in RelA / SpoT proteins; Region: RelA_SpoT; smart00954
548476001796	metal binding triad [ion binding]; metal-binding site
548476001797	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
548476001798	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
548476001799	AAA domain; Region: AAA_14; pfam13173
548476001800	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
548476001801	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
548476001802	arginine deiminase; Provisional; Region: PRK01388
548476001803	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
548476001804	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
548476001805	Uncharacterized conserved protein [Function unknown]; Region: COG1479
548476001806	Protein of unknown function DUF262; Region: DUF262; pfam03235
548476001807	Uncharacterized conserved protein [Function unknown]; Region: COG3472
548476001808	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
548476001809	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
548476001810	inhibitor site; inhibition site
548476001811	active site
548476001812	dimer interface [polypeptide binding]; other site
548476001813	catalytic residue [active]
548476001814	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
548476001815	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
548476001816	putative active site cavity [active]
548476001817	Transcriptional regulators [Transcription]; Region: FadR; COG2186
548476001818	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
548476001819	DNA-binding site [nucleotide binding]; DNA binding site
548476001820	FCD domain; Region: FCD; pfam07729
548476001821	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
548476001822	Na binding site [ion binding]; other site
548476001823	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
548476001824	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
548476001825	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
548476001826	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
548476001827	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548476001828	dimer interface [polypeptide binding]; other site
548476001829	conserved gate region; other site
548476001830	putative PBP binding loops; other site
548476001831	ABC-ATPase subunit interface; other site
548476001832	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
548476001833	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
548476001834	Walker A/P-loop; other site
548476001835	ATP binding site [chemical binding]; other site
548476001836	Q-loop/lid; other site
548476001837	ABC transporter signature motif; other site
548476001838	Walker B; other site
548476001839	D-loop; other site
548476001840	H-loop/switch region; other site
548476001841	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
548476001842	homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
548476001843	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
548476001844	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
548476001845	AAA domain; Region: AAA_33; pfam13671
548476001846	ATP-binding site [chemical binding]; other site
548476001847	Gluconate-6-phosphate binding site [chemical binding]; other site
548476001848	fructuronate transporter; Provisional; Region: PRK10034; cl15264
548476001849	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
548476001850	Predicted esterase [General function prediction only]; Region: COG0627
548476001851	Cation efflux family; Region: Cation_efflux; cl00316
548476001852	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548476001853	metabolite-proton symporter; Region: 2A0106; TIGR00883
548476001854	putative substrate translocation pore; other site
548476001855	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
548476001856	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
548476001857	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
548476001858	active site
548476001859	allantoate amidohydrolase; Reviewed; Region: PRK09290
548476001860	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
548476001861	active site
548476001862	metal binding site [ion binding]; metal-binding site
548476001863	dimer interface [polypeptide binding]; other site
548476001864	MarR family; Region: MarR_2; pfam12802
548476001865	Protein of unknown function (DUF419); Region: DUF419; cl15265
548476001866	enoyl-CoA hydratase; Provisional; Region: PRK06688
548476001867	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
548476001868	substrate binding site [chemical binding]; other site
548476001869	oxyanion hole (OAH) forming residues; other site
548476001870	trimer interface [polypeptide binding]; other site
548476001871	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
548476001872	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
548476001873	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
548476001874	FMN binding site [chemical binding]; other site
548476001875	substrate binding site [chemical binding]; other site
548476001876	putative catalytic residue [active]
548476001877	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
548476001878	active site
548476001879	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
548476001880	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
548476001881	active site
548476001882	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
548476001883	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
548476001884	NAD(P) binding site [chemical binding]; other site
548476001885	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
548476001886	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
548476001887	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
548476001888	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
548476001889	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
548476001890	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
548476001891	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
548476001892	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
548476001893	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
548476001894	Uncharacterized membrane protein [Function unknown]; Region: COG3949
548476001895	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
548476001896	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
548476001897	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
548476001898	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
548476001899	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
548476001900	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
548476001901	inhibitor-cofactor binding pocket; inhibition site
548476001902	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548476001903	catalytic residue [active]
548476001904	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
548476001905	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
548476001906	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
548476001907	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
548476001908	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
548476001909	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
548476001910	inhibitor-cofactor binding pocket; inhibition site
548476001911	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548476001912	catalytic residue [active]
548476001913	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
548476001914	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
548476001915	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
548476001916	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
548476001917	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
548476001918	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
548476001919	NAD(P) binding site [chemical binding]; other site
548476001920	catalytic residues [active]
548476001921	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
548476001922	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
548476001923	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548476001924	homodimer interface [polypeptide binding]; other site
548476001925	catalytic residue [active]
548476001926	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
548476001927	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
548476001928	thiamine pyrophosphate protein; Validated; Region: PRK08199
548476001929	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
548476001930	PYR/PP interface [polypeptide binding]; other site
548476001931	dimer interface [polypeptide binding]; other site
548476001932	TPP binding site [chemical binding]; other site
548476001933	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
548476001934	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
548476001935	TPP-binding site [chemical binding]; other site
548476001936	Transcriptional regulator [Transcription]; Region: LysR; COG0583
548476001937	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
548476001938	dimerization interface [polypeptide binding]; other site
548476001939	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
548476001940	putative active site [active]
548476001941	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
548476001942	TIGR03089 family protein; Region: TIGR03089
548476001943	Transcriptional regulator [Transcription]; Region: LytR; COG1316
548476001944	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
548476001945	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
548476001946	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
548476001947	Probable Catalytic site; other site
548476001948	metal-binding site
548476001949	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
548476001950	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
548476001951	active site
548476001952	Substrate binding site; other site
548476001953	Mg++ binding site; other site
548476001954	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
548476001955	putative trimer interface [polypeptide binding]; other site
548476001956	putative CoA binding site [chemical binding]; other site
548476001957	Transcription factor WhiB; Region: Whib; pfam02467
548476001958	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
548476001959	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
548476001960	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
548476001961	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
548476001962	active site
548476001963	substrate binding site [chemical binding]; other site
548476001964	metal binding site [ion binding]; metal-binding site
548476001965	ferredoxin-NADP+ reductase; Region: PLN02852
548476001966	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
548476001967	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
548476001968	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
548476001969	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
548476001970	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
548476001971	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
548476001972	putative active site [active]
548476001973	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
548476001974	active site
548476001975	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
548476001976	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
548476001977	active site
548476001978	SAM binding site [chemical binding]; other site
548476001979	homodimer interface [polypeptide binding]; other site
548476001980	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
548476001981	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
548476001982	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
548476001983	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
548476001984	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
548476001985	TMP-binding site; other site
548476001986	ATP-binding site [chemical binding]; other site
548476001987	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
548476001988	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548476001989	active site
548476001990	phosphorylation site [posttranslational modification]
548476001991	intermolecular recognition site; other site
548476001992	dimerization interface [polypeptide binding]; other site
548476001993	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
548476001994	DNA binding site [nucleotide binding]
548476001995	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
548476001996	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
548476001997	dimerization interface [polypeptide binding]; other site
548476001998	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
548476001999	dimer interface [polypeptide binding]; other site
548476002000	phosphorylation site [posttranslational modification]
548476002001	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548476002002	ATP binding site [chemical binding]; other site
548476002003	Mg2+ binding site [ion binding]; other site
548476002004	G-X-G motif; other site
548476002005	lipoprotein LpqB; Provisional; Region: PRK13616
548476002006	Sporulation and spore germination; Region: Germane; pfam10646
548476002007	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
548476002008	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
548476002009	active site
548476002010	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
548476002011	30S subunit binding site; other site
548476002012	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
548476002013	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
548476002014	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
548476002015	nucleotide binding region [chemical binding]; other site
548476002016	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
548476002017	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
548476002018	Predicted GTPases [General function prediction only]; Region: COG1162
548476002019	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
548476002020	GTPase/Zn-binding domain interface [polypeptide binding]; other site
548476002021	GTP/Mg2+ binding site [chemical binding]; other site
548476002022	G4 box; other site
548476002023	G5 box; other site
548476002024	G1 box; other site
548476002025	Switch I region; other site
548476002026	G2 box; other site
548476002027	G3 box; other site
548476002028	Switch II region; other site
548476002029	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
548476002030	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
548476002031	hinge; other site
548476002032	active site
548476002033	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
548476002034	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
548476002035	putative deacylase active site [active]
548476002036	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
548476002037	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
548476002038	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
548476002039	DNA binding residues [nucleotide binding]
548476002040	Transcription factor WhiB; Region: Whib; pfam02467
548476002041	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
548476002042	DEAD-like helicases superfamily; Region: DEXDc; smart00487
548476002043	ATP binding site [chemical binding]; other site
548476002044	Mg++ binding site [ion binding]; other site
548476002045	motif III; other site
548476002046	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
548476002047	nucleotide binding region [chemical binding]; other site
548476002048	ATP-binding site [chemical binding]; other site
548476002049	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
548476002050	Protein of unknown function (DUF3152); Region: DUF3152; pfam11350
548476002051	TIGR02569 family protein; Region: TIGR02569_actnb
548476002052	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
548476002053	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
548476002054	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
548476002055	Part of AAA domain; Region: AAA_19; pfam13245
548476002056	Family description; Region: UvrD_C_2; pfam13538
548476002057	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
548476002058	Ion channel; Region: Ion_trans_2; pfam07885
548476002059	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
548476002060	TrkA-N domain; Region: TrkA_N; pfam02254
548476002061	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
548476002062	RPB3 interaction site [polypeptide binding]; other site
548476002063	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
548476002064	putative NADH binding site [chemical binding]; other site
548476002065	putative active site [active]
548476002066	nudix motif; other site
548476002067	putative metal binding site [ion binding]; other site
548476002068	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
548476002069	Part of AAA domain; Region: AAA_19; pfam13245
548476002070	Family description; Region: UvrD_C_2; pfam13538
548476002071	HRDC domain; Region: HRDC; pfam00570
548476002072	Protein of unknown function DUF45; Region: DUF45; pfam01863
548476002073	putative hydrolase; Region: TIGR03624
548476002074	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
548476002075	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
548476002076	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
548476002077	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
548476002078	hypothetical protein; Validated; Region: PRK00068
548476002079	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
548476002080	L-aspartate dehydrogenase; Provisional; Region: PRK13303
548476002081	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
548476002082	Domain of unknown function DUF108; Region: DUF108; pfam01958
548476002083	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
548476002084	metal ion-dependent adhesion site (MIDAS); other site
548476002085	Domain of unknown function (DUF1963); Region: DUF1963; pfam09234
548476002086	Domain of unknown function (DUF1990); Region: DUF1990; cl01969
548476002087	Predicted membrane protein [Function unknown]; Region: COG2311
548476002088	Protein of unknown function (DUF418); Region: DUF418; cl12135
548476002089	Protein of unknown function (DUF418); Region: DUF418; pfam04235
548476002090	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
548476002091	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
548476002092	intersubunit interface [polypeptide binding]; other site
548476002093	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
548476002094	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
548476002095	FAD binding pocket [chemical binding]; other site
548476002096	FAD binding motif [chemical binding]; other site
548476002097	phosphate binding motif [ion binding]; other site
548476002098	NAD binding pocket [chemical binding]; other site
548476002099	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
548476002100	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
548476002101	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
548476002102	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
548476002103	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
548476002104	Walker A/P-loop; other site
548476002105	ATP binding site [chemical binding]; other site
548476002106	Q-loop/lid; other site
548476002107	ABC transporter signature motif; other site
548476002108	Walker B; other site
548476002109	D-loop; other site
548476002110	H-loop/switch region; other site
548476002111	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
548476002112	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
548476002113	siderophore binding site; other site
548476002114	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
548476002115	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
548476002116	ABC-ATPase subunit  interface; other site
548476002117	dimer interface [polypeptide binding]; other site
548476002118	putative PBP binding regions; other site
548476002119	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
548476002120	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
548476002121	ABC-ATPase subunit  interface; other site
548476002122	dimer interface [polypeptide binding]; other site
548476002123	putative PBP binding regions; other site
548476002124	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
548476002125	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
548476002126	siderophore binding site; other site
548476002127	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
548476002128	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
548476002129	intersubunit interface [polypeptide binding]; other site
548476002130	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
548476002131	nudix motif; other site
548476002132	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
548476002133	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
548476002134	active site
548476002135	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
548476002136	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
548476002137	active site
548476002138	peptide chain release factor 2; Validated; Region: prfB; PRK00578
548476002139	This domain is found in peptide chain release factors; Region: PCRF; smart00937
548476002140	RF-1 domain; Region: RF-1; pfam00472
548476002141	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
548476002142	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548476002143	Walker A/P-loop; other site
548476002144	ATP binding site [chemical binding]; other site
548476002145	Q-loop/lid; other site
548476002146	ABC transporter signature motif; other site
548476002147	Walker B; other site
548476002148	D-loop; other site
548476002149	H-loop/switch region; other site
548476002150	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
548476002151	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
548476002152	SmpB-tmRNA interface; other site
548476002153	Protein of unknown function, DUF488; Region: DUF488; cl01246
548476002154	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
548476002155	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
548476002156	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
548476002157	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
548476002158	DJ-1 family protein; Region: not_thiJ; TIGR01383
548476002159	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
548476002160	conserved cys residue [active]
548476002161	Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
548476002162	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
548476002163	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
548476002164	amidohydrolase; Region: amidohydrolases; TIGR01891
548476002165	metal binding site [ion binding]; metal-binding site
548476002166	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
548476002167	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
548476002168	intersubunit interface [polypeptide binding]; other site
548476002169	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
548476002170	ABC-ATPase subunit  interface; other site
548476002171	dimer interface [polypeptide binding]; other site
548476002172	putative PBP binding regions; other site
548476002173	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
548476002174	ABC-ATPase subunit  interface; other site
548476002175	dimer interface [polypeptide binding]; other site
548476002176	putative PBP binding regions; other site
548476002177	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
548476002178	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
548476002179	Walker A/P-loop; other site
548476002180	ATP binding site [chemical binding]; other site
548476002181	Q-loop/lid; other site
548476002182	ABC transporter signature motif; other site
548476002183	Walker B; other site
548476002184	D-loop; other site
548476002185	H-loop/switch region; other site
548476002186	putative transposase OrfB; Reviewed; Region: PHA02517
548476002187	HTH-like domain; Region: HTH_21; pfam13276
548476002188	Integrase core domain; Region: rve; pfam00665
548476002189	Integrase core domain; Region: rve_3; pfam13683
548476002190	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548476002191	Transposase; Region: HTH_Tnp_1; cl17663
548476002192	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
548476002193	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
548476002194	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
548476002195	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
548476002196	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
548476002197	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
548476002198	aminotransferase; Validated; Region: PRK07777
548476002199	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
548476002200	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548476002201	homodimer interface [polypeptide binding]; other site
548476002202	catalytic residue [active]
548476002203	Protein of unknown function (DUF3239); Region: DUF3239; pfam11580
548476002204	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
548476002205	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
548476002206	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
548476002207	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
548476002208	ATP binding site [chemical binding]; other site
548476002209	putative Mg++ binding site [ion binding]; other site
548476002210	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
548476002211	nucleotide binding region [chemical binding]; other site
548476002212	ATP-binding site [chemical binding]; other site
548476002213	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
548476002214	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
548476002215	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
548476002216	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
548476002217	Protein of unknown function (DUF3235); Region: DUF3235; pfam11574
548476002218	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
548476002219	DNA-binding site [nucleotide binding]; DNA binding site
548476002220	RNA-binding motif; other site
548476002221	Protein of unknown function (DUF2771); Region: DUF2771; pfam10969
548476002222	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
548476002223	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
548476002224	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
548476002225	Sulfate transporter family; Region: Sulfate_transp; pfam00916
548476002226	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
548476002227	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
548476002228	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
548476002229	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
548476002230	catalytic residue [active]
548476002231	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
548476002232	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
548476002233	dimer interface [polypeptide binding]; other site
548476002234	active site
548476002235	citrylCoA binding site [chemical binding]; other site
548476002236	NADH binding [chemical binding]; other site
548476002237	cationic pore residues; other site
548476002238	oxalacetate/citrate binding site [chemical binding]; other site
548476002239	coenzyme A binding site [chemical binding]; other site
548476002240	catalytic triad [active]
548476002241	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
548476002242	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
548476002243	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
548476002244	active site
548476002245	catalytic tetrad [active]
548476002246	Protein of unknown function, DUF485; Region: DUF485; pfam04341
548476002247	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
548476002248	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
548476002249	Na binding site [ion binding]; other site
548476002250	Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
548476002251	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
548476002252	OsmC-like protein; Region: OsmC; pfam02566
548476002253	Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399
548476002254	putative active site [active]
548476002255	putative metal binding site [ion binding]; other site
548476002256	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
548476002257	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
548476002258	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
548476002259	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548476002260	Transposase; Region: HTH_Tnp_1; cl17663
548476002261	putative transposase OrfB; Reviewed; Region: PHA02517
548476002262	HTH-like domain; Region: HTH_21; pfam13276
548476002263	Integrase core domain; Region: rve; pfam00665
548476002264	Integrase core domain; Region: rve_3; pfam13683
548476002265	Protein of unknown function (DUF2871); Region: DUF2871; pfam11070
548476002266	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
548476002267	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548476002268	Walker A/P-loop; other site
548476002269	ATP binding site [chemical binding]; other site
548476002270	Q-loop/lid; other site
548476002271	ABC transporter signature motif; other site
548476002272	Walker B; other site
548476002273	D-loop; other site
548476002274	H-loop/switch region; other site
548476002275	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
548476002276	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
548476002277	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548476002278	Walker A/P-loop; other site
548476002279	ATP binding site [chemical binding]; other site
548476002280	Q-loop/lid; other site
548476002281	ABC transporter signature motif; other site
548476002282	Walker B; other site
548476002283	D-loop; other site
548476002284	H-loop/switch region; other site
548476002285	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
548476002286	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
548476002287	Walker A/P-loop; other site
548476002288	ATP binding site [chemical binding]; other site
548476002289	Q-loop/lid; other site
548476002290	ABC transporter signature motif; other site
548476002291	Walker B; other site
548476002292	D-loop; other site
548476002293	H-loop/switch region; other site
548476002294	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548476002295	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
548476002296	Walker A/P-loop; other site
548476002297	ATP binding site [chemical binding]; other site
548476002298	Q-loop/lid; other site
548476002299	ABC transporter signature motif; other site
548476002300	Walker B; other site
548476002301	D-loop; other site
548476002302	H-loop/switch region; other site
548476002303	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
548476002304	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
548476002305	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
548476002306	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
548476002307	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
548476002308	folate binding site [chemical binding]; other site
548476002309	NADP+ binding site [chemical binding]; other site
548476002310	thymidylate synthase; Reviewed; Region: thyA; PRK01827
548476002311	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
548476002312	dimerization interface [polypeptide binding]; other site
548476002313	active site
548476002314	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
548476002315	active site
548476002316	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
548476002317	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
548476002318	ATP binding site [chemical binding]; other site
548476002319	putative Mg++ binding site [ion binding]; other site
548476002320	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
548476002321	nucleotide binding region [chemical binding]; other site
548476002322	ATP-binding site [chemical binding]; other site
548476002323	DEAD/H associated; Region: DEAD_assoc; pfam08494
548476002324	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
548476002325	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
548476002326	phosphate binding site [ion binding]; other site
548476002327	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
548476002328	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
548476002329	putative DNA binding site [nucleotide binding]; other site
548476002330	catalytic residue [active]
548476002331	putative H2TH interface [polypeptide binding]; other site
548476002332	putative catalytic residues [active]
548476002333	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
548476002334	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
548476002335	hypothetical protein; Provisional; Region: PRK11770
548476002336	Domain of unknown function (DUF307); Region: DUF307; pfam03733
548476002337	Domain of unknown function (DUF307); Region: DUF307; pfam03733
548476002338	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
548476002339	active site
548476002340	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
548476002341	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
548476002342	active site
548476002343	dimer interface [polypeptide binding]; other site
548476002344	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
548476002345	dimer interface [polypeptide binding]; other site
548476002346	active site
548476002347	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
548476002348	active site
548476002349	substrate binding sites [chemical binding]; other site
548476002350	hypothetical protein; Provisional; Region: PRK07857
548476002351	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
548476002352	Part of AAA domain; Region: AAA_19; pfam13245
548476002353	Family description; Region: UvrD_C_2; pfam13538
548476002354	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
548476002355	Peptidase family M23; Region: Peptidase_M23; pfam01551
548476002356	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
548476002357	FtsX-like permease family; Region: FtsX; pfam02687
548476002358	FtsX-like permease family; Region: FtsX; pfam02687
548476002359	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
548476002360	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
548476002361	Walker A/P-loop; other site
548476002362	ATP binding site [chemical binding]; other site
548476002363	Q-loop/lid; other site
548476002364	ABC transporter signature motif; other site
548476002365	Walker B; other site
548476002366	D-loop; other site
548476002367	H-loop/switch region; other site
548476002368	Predicted transcriptional regulators [Transcription]; Region: COG1695
548476002369	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
548476002370	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
548476002371	Peptidase family M23; Region: Peptidase_M23; pfam01551
548476002372	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
548476002373	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
548476002374	active site
548476002375	cosubstrate binding site; other site
548476002376	substrate binding site [chemical binding]; other site
548476002377	catalytic site [active]
548476002378	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
548476002379	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
548476002380	purine monophosphate binding site [chemical binding]; other site
548476002381	dimer interface [polypeptide binding]; other site
548476002382	putative catalytic residues [active]
548476002383	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
548476002384	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
548476002385	Protein kinase domain; Region: Pkinase; pfam00069
548476002386	Catalytic domain of Protein Kinases; Region: PKc; cd00180
548476002387	active site
548476002388	ATP binding site [chemical binding]; other site
548476002389	substrate binding site [chemical binding]; other site
548476002390	activation loop (A-loop); other site
548476002391	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
548476002392	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
548476002393	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
548476002394	30S ribosomal protein S18; Provisional; Region: PRK13401
548476002395	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
548476002396	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
548476002397	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
548476002398	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
548476002399	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
548476002400	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
548476002401	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548476002402	active site
548476002403	phosphorylation site [posttranslational modification]
548476002404	intermolecular recognition site; other site
548476002405	dimerization interface [polypeptide binding]; other site
548476002406	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
548476002407	DNA binding site [nucleotide binding]
548476002408	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
548476002409	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
548476002410	dimerization interface [polypeptide binding]; other site
548476002411	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
548476002412	dimer interface [polypeptide binding]; other site
548476002413	phosphorylation site [posttranslational modification]
548476002414	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548476002415	ATP binding site [chemical binding]; other site
548476002416	Mg2+ binding site [ion binding]; other site
548476002417	G-X-G motif; other site
548476002418	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
548476002419	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
548476002420	protein binding site [polypeptide binding]; other site
548476002421	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
548476002422	MPT binding site; other site
548476002423	trimer interface [polypeptide binding]; other site
548476002424	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
548476002425	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
548476002426	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
548476002427	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
548476002428	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
548476002429	UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210
548476002430	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
548476002431	active site
548476002432	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
548476002433	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
548476002434	dimer interface [polypeptide binding]; other site
548476002435	putative functional site; other site
548476002436	putative MPT binding site; other site
548476002437	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
548476002438	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
548476002439	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
548476002440	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
548476002441	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
548476002442	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
548476002443	DNA binding site [nucleotide binding]
548476002444	active site
548476002445	Predicted membrane protein [Function unknown]; Region: COG2259
548476002446	Predicted integral membrane protein [Function unknown]; Region: COG5660
548476002447	Putative zinc-finger; Region: zf-HC2; pfam13490
548476002448	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
548476002449	Predicted methyltransferases [General function prediction only]; Region: COG0313
548476002450	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
548476002451	putative SAM binding site [chemical binding]; other site
548476002452	putative homodimer interface [polypeptide binding]; other site
548476002453	BCCT family transporter; Region: BCCT; pfam02028
548476002454	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
548476002455	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
548476002456	active site
548476002457	HIGH motif; other site
548476002458	KMSKS motif; other site
548476002459	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
548476002460	tRNA binding surface [nucleotide binding]; other site
548476002461	anticodon binding site; other site
548476002462	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
548476002463	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548476002464	putative substrate translocation pore; other site
548476002465	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
548476002466	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
548476002467	non-specific DNA binding site [nucleotide binding]; other site
548476002468	salt bridge; other site
548476002469	sequence-specific DNA binding site [nucleotide binding]; other site
548476002470	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
548476002471	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
548476002472	Coenzyme A binding pocket [chemical binding]; other site
548476002473	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
548476002474	active site
548476002475	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
548476002476	Domain of unknown function (DUF348); Region: DUF348; pfam03990
548476002477	Domain of unknown function (DUF348); Region: DUF348; pfam03990
548476002478	G5 domain; Region: G5; pfam07501
548476002479	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
548476002480	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
548476002481	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
548476002482	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
548476002483	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
548476002484	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
548476002485	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
548476002486	ABC transporter; Region: ABC_tran_2; pfam12848
548476002487	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
548476002488	Predicted permeases [General function prediction only]; Region: COG0679
548476002489	Uncharacterized conserved protein [Function unknown]; Region: COG1359
548476002490	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
548476002491	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
548476002492	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
548476002493	catalytic triad [active]
548476002494	catalytic triad [active]
548476002495	oxyanion hole [active]
548476002496	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
548476002497	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
548476002498	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
548476002499	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
548476002500	substrate binding site [chemical binding]; other site
548476002501	oxyanion hole (OAH) forming residues; other site
548476002502	trimer interface [polypeptide binding]; other site
548476002503	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
548476002504	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
548476002505	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
548476002506	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
548476002507	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
548476002508	NAD(P) binding site [chemical binding]; other site
548476002509	active site
548476002510	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
548476002511	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
548476002512	trimer interface [polypeptide binding]; other site
548476002513	putative metal binding site [ion binding]; other site
548476002514	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
548476002515	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
548476002516	active site
548476002517	nucleophile elbow; other site
548476002518	Predicted permease [General function prediction only]; Region: COG2985
548476002519	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
548476002520	TrkA-C domain; Region: TrkA_C; pfam02080
548476002521	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
548476002522	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
548476002523	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
548476002524	dimer interface [polypeptide binding]; other site
548476002525	active site
548476002526	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
548476002527	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
548476002528	substrate binding site [chemical binding]; other site
548476002529	oxyanion hole (OAH) forming residues; other site
548476002530	trimer interface [polypeptide binding]; other site
548476002531	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
548476002532	enoyl-CoA hydratase; Provisional; Region: PRK05862
548476002533	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
548476002534	substrate binding site [chemical binding]; other site
548476002535	oxyanion hole (OAH) forming residues; other site
548476002536	trimer interface [polypeptide binding]; other site
548476002537	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
548476002538	MarR family; Region: MarR; pfam01047
548476002539	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
548476002540	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
548476002541	acyl-activating enzyme (AAE) consensus motif; other site
548476002542	AMP binding site [chemical binding]; other site
548476002543	active site
548476002544	CoA binding site [chemical binding]; other site
548476002545	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
548476002546	acyl-coenzyme A oxidase; Region: PLN02526
548476002547	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
548476002548	active site
548476002549	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
548476002550	NAD(P) binding site [chemical binding]; other site
548476002551	active site
548476002552	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
548476002553	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
548476002554	active site
548476002555	Zn binding site [ion binding]; other site
548476002556	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
548476002557	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
548476002558	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
548476002559	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
548476002560	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
548476002561	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
548476002562	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
548476002563	tetrameric interface [polypeptide binding]; other site
548476002564	NAD binding site [chemical binding]; other site
548476002565	catalytic residues [active]
548476002566	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
548476002567	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
548476002568	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
548476002569	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
548476002570	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
548476002571	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
548476002572	CoA-transferase family III; Region: CoA_transf_3; pfam02515
548476002573	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
548476002574	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
548476002575	G1 box; other site
548476002576	putative GEF interaction site [polypeptide binding]; other site
548476002577	GTP/Mg2+ binding site [chemical binding]; other site
548476002578	Switch I region; other site
548476002579	G2 box; other site
548476002580	G3 box; other site
548476002581	Switch II region; other site
548476002582	G4 box; other site
548476002583	G5 box; other site
548476002584	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
548476002585	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
548476002586	NAD(P) binding site [chemical binding]; other site
548476002587	active site
548476002588	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
548476002589	putative active site [active]
548476002590	catalytic residue [active]
548476002591	Nitronate monooxygenase; Region: NMO; pfam03060
548476002592	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
548476002593	FMN binding site [chemical binding]; other site
548476002594	substrate binding site [chemical binding]; other site
548476002595	putative catalytic residue [active]
548476002596	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
548476002597	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
548476002598	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
548476002599	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
548476002600	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
548476002601	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
548476002602	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
548476002603	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
548476002604	putative active site [active]
548476002605	catalytic residue [active]
548476002606	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
548476002607	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
548476002608	5S rRNA interface [nucleotide binding]; other site
548476002609	CTC domain interface [polypeptide binding]; other site
548476002610	L16 interface [polypeptide binding]; other site
548476002611	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
548476002612	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
548476002613	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
548476002614	active site
548476002615	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
548476002616	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
548476002617	Substrate binding site; other site
548476002618	Mg++ binding site; other site
548476002619	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
548476002620	active site
548476002621	substrate binding site [chemical binding]; other site
548476002622	CoA binding site [chemical binding]; other site
548476002623	Major Facilitator Superfamily; Region: MFS_1; pfam07690
548476002624	multicopper oxidase; Provisional; Region: PRK10965
548476002625	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
548476002626	Multicopper oxidase; Region: Cu-oxidase; pfam00394
548476002627	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
548476002628	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719
548476002629	GIY-YIG motif/motif A; other site
548476002630	active site
548476002631	catalytic site [active]
548476002632	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
548476002633	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
548476002634	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729
548476002635	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608
548476002636	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
548476002637	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645
548476002638	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
548476002639	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
548476002640	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755
548476002641	Predicted membrane protein [Function unknown]; Region: COG2860
548476002642	UPF0126 domain; Region: UPF0126; pfam03458
548476002643	UPF0126 domain; Region: UPF0126; pfam03458
548476002644	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
548476002645	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
548476002646	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
548476002647	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
548476002648	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
548476002649	ATP binding site [chemical binding]; other site
548476002650	putative Mg++ binding site [ion binding]; other site
548476002651	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
548476002652	nucleotide binding region [chemical binding]; other site
548476002653	ATP-binding site [chemical binding]; other site
548476002654	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
548476002655	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
548476002656	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334
548476002657	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
548476002658	homodimer interface [polypeptide binding]; other site
548476002659	metal binding site [ion binding]; metal-binding site
548476002660	Alpha helical Porin B; Region: PorB; pfam11565
548476002661	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
548476002662	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
548476002663	N-acetyl-D-glucosamine binding site [chemical binding]; other site
548476002664	enolase; Provisional; Region: eno; PRK00077
548476002665	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
548476002666	dimer interface [polypeptide binding]; other site
548476002667	metal binding site [ion binding]; metal-binding site
548476002668	substrate binding pocket [chemical binding]; other site
548476002669	Septum formation initiator; Region: DivIC; pfam04977
548476002670	Uncharacterized conserved protein [Function unknown]; Region: COG1507
548476002671	exopolyphosphatase; Region: exo_poly_only; TIGR03706
548476002672	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
548476002673	Bax inhibitor 1 like; Region: BaxI_1; cl17691
548476002674	putative transposase OrfB; Reviewed; Region: PHA02517
548476002675	HTH-like domain; Region: HTH_21; pfam13276
548476002676	Integrase core domain; Region: rve; pfam00665
548476002677	Integrase core domain; Region: rve_3; pfam13683
548476002678	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548476002679	Transposase; Region: HTH_Tnp_1; pfam01527
548476002680	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
548476002681	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
548476002682	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
548476002683	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
548476002684	mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446
548476002685	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
548476002686	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
548476002687	catalytic residue [active]
548476002688	putative FPP diphosphate  binding site; other site
548476002689	putative FPP binding hydrophobic cleft; other site
548476002690	dimer interface [polypeptide binding]; other site
548476002691	putative IPP diphosphate binding site; other site
548476002692	pantothenate kinase; Provisional; Region: PRK05439
548476002693	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
548476002694	ATP-binding site [chemical binding]; other site
548476002695	CoA-binding site [chemical binding]; other site
548476002696	Mg2+-binding site [ion binding]; other site
548476002697	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
548476002698	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
548476002699	dimer interface [polypeptide binding]; other site
548476002700	active site
548476002701	glycine-pyridoxal phosphate binding site [chemical binding]; other site
548476002702	folate binding site [chemical binding]; other site
548476002703	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
548476002704	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
548476002705	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
548476002706	putative active site [active]
548476002707	PhoH-like protein; Region: PhoH; pfam02562
548476002708	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
548476002709	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
548476002710	Coenzyme A binding pocket [chemical binding]; other site
548476002711	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548476002712	Major Facilitator Superfamily; Region: MFS_1; pfam07690
548476002713	putative substrate translocation pore; other site
548476002714	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548476002715	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
548476002716	fumarate hydratase; Reviewed; Region: fumC; PRK00485
548476002717	Class II fumarases; Region: Fumarase_classII; cd01362
548476002718	active site
548476002719	tetramer interface [polypeptide binding]; other site
548476002720	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
548476002721	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
548476002722	putative active site [active]
548476002723	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
548476002724	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
548476002725	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
548476002726	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
548476002727	generic binding surface II; other site
548476002728	generic binding surface I; other site
548476002729	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
548476002730	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
548476002731	RmuC family; Region: RmuC; pfam02646
548476002732	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
548476002733	Domain of unknown function DUF20; Region: UPF0118; pfam01594
548476002734	GTP-binding protein YchF; Reviewed; Region: PRK09601
548476002735	YchF GTPase; Region: YchF; cd01900
548476002736	G1 box; other site
548476002737	GTP/Mg2+ binding site [chemical binding]; other site
548476002738	Switch I region; other site
548476002739	G2 box; other site
548476002740	Switch II region; other site
548476002741	G3 box; other site
548476002742	G4 box; other site
548476002743	G5 box; other site
548476002744	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
548476002745	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
548476002746	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
548476002747	metal binding site [ion binding]; metal-binding site
548476002748	putative dimer interface [polypeptide binding]; other site
548476002749	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
548476002750	intracellular protease, PfpI family; Region: PfpI; TIGR01382
548476002751	proposed catalytic triad [active]
548476002752	conserved cys residue [active]
548476002753	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
548476002754	Cation efflux family; Region: Cation_efflux; cl00316
548476002755	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
548476002756	succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407
548476002757	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
548476002758	NAD(P) binding site [chemical binding]; other site
548476002759	catalytic residues [active]
548476002760	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
548476002761	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
548476002762	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
548476002763	catalytic residue [active]
548476002764	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
548476002765	FAD binding domain; Region: FAD_binding_4; pfam01565
548476002766	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
548476002767	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548476002768	Major Facilitator Superfamily; Region: MFS_1; pfam07690
548476002769	putative substrate translocation pore; other site
548476002770	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14590
548476002771	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
548476002772	active site
548476002773	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
548476002774	Integrase core domain; Region: rve; pfam00665
548476002775	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
548476002776	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
548476002777	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
548476002778	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
548476002779	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
548476002780	PRC-barrel domain; Region: PRC; pfam05239
548476002781	Domain of unknown function (DUF2382); Region: DUF2382; pfam09557
548476002782	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
548476002783	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
548476002784	molybdopterin cofactor binding site; other site
548476002785	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
548476002786	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
548476002787	molybdopterin cofactor binding site; other site
548476002788	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
548476002789	4Fe-4S binding domain; Region: Fer4; cl02805
548476002790	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
548476002791	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
548476002792	dimerization interface [polypeptide binding]; other site
548476002793	putative ATP binding site [chemical binding]; other site
548476002794	selenocysteine synthase; Provisional; Region: PRK04311
548476002795	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
548476002796	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
548476002797	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
548476002798	catalytic residue [active]
548476002799	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
548476002800	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
548476002801	G1 box; other site
548476002802	GTP/Mg2+ binding site [chemical binding]; other site
548476002803	G2 box; other site
548476002804	Switch I region; other site
548476002805	G3 box; other site
548476002806	Switch II region; other site
548476002807	G4 box; other site
548476002808	G5 box; other site
548476002809	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
548476002810	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
548476002811	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
548476002812	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
548476002813	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
548476002814	non-specific DNA binding site [nucleotide binding]; other site
548476002815	salt bridge; other site
548476002816	sequence-specific DNA binding site [nucleotide binding]; other site
548476002817	zinc transporter ZupT; Provisional; Region: PRK04201
548476002818	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
548476002819	Protein of unknown function (DUF402); Region: DUF402; cl00979
548476002820	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
548476002821	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
548476002822	G1 box; other site
548476002823	GTP/Mg2+ binding site [chemical binding]; other site
548476002824	G2 box; other site
548476002825	Switch I region; other site
548476002826	G3 box; other site
548476002827	Switch II region; other site
548476002828	G4 box; other site
548476002829	G5 box; other site
548476002830	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
548476002831	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
548476002832	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
548476002833	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
548476002834	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
548476002835	Ferredoxin [Energy production and conversion]; Region: COG1146
548476002836	4Fe-4S binding domain; Region: Fer4; cl02805
548476002837	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
548476002838	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
548476002839	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548476002840	homodimer interface [polypeptide binding]; other site
548476002841	catalytic residue [active]
548476002842	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
548476002843	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
548476002844	active site
548476002845	Predicted membrane protein [Function unknown]; Region: COG2246
548476002846	GtrA-like protein; Region: GtrA; pfam04138
548476002847	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
548476002848	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
548476002849	sequence-specific DNA binding site [nucleotide binding]; other site
548476002850	salt bridge; other site
548476002851	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
548476002852	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
548476002853	putative active site [active]
548476002854	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
548476002855	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
548476002856	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
548476002857	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
548476002858	putative trimer interface [polypeptide binding]; other site
548476002859	putative CoA binding site [chemical binding]; other site
548476002860	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
548476002861	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
548476002862	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
548476002863	metal binding site [ion binding]; metal-binding site
548476002864	putative dimer interface [polypeptide binding]; other site
548476002865	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
548476002866	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
548476002867	dihydropteroate synthase; Region: DHPS; TIGR01496
548476002868	substrate binding pocket [chemical binding]; other site
548476002869	dimer interface [polypeptide binding]; other site
548476002870	inhibitor binding site; inhibition site
548476002871	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
548476002872	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
548476002873	DivIVA domain; Region: DivI1A_domain; TIGR03544
548476002874	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
548476002875	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
548476002876	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548476002877	S-adenosylmethionine binding site [chemical binding]; other site
548476002878	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
548476002879	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
548476002880	active site
548476002881	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
548476002882	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
548476002883	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
548476002884	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
548476002885	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
548476002886	ligand binding site; other site
548476002887	oligomer interface; other site
548476002888	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
548476002889	dimer interface [polypeptide binding]; other site
548476002890	N-terminal domain interface [polypeptide binding]; other site
548476002891	sulfate 1 binding site; other site
548476002892	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
548476002893	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
548476002894	RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
548476002895	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
548476002896	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
548476002897	DNA binding residues [nucleotide binding]
548476002898	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806
548476002899	sec-independent translocase; Provisional; Region: tatB; PRK00182
548476002900	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
548476002901	Domain of unknown function DUF59; Region: DUF59; pfam01883
548476002902	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
548476002903	G5 domain; Region: G5; pfam07501
548476002904	G5 domain; Region: G5; pfam07501
548476002905	G5 domain; Region: G5; pfam07501
548476002906	G5 domain; Region: G5; pfam07501
548476002907	G5 domain; Region: G5; pfam07501
548476002908	G5 domain; Region: G5; pfam07501
548476002909	G5 domain; Region: G5; pfam07501
548476002910	G5 domain; Region: G5; pfam07501
548476002911	G5 domain; Region: G5; pfam07501
548476002912	G5 domain; Region: G5; pfam07501
548476002913	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
548476002914	Integrase core domain; Region: rve; pfam00665
548476002915	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
548476002916	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
548476002917	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508
548476002918	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
548476002919	2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; Region: SucA; COG0567
548476002920	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
548476002921	TPP-binding site [chemical binding]; other site
548476002922	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
548476002923	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
548476002924	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
548476002925	substrate binding pocket [chemical binding]; other site
548476002926	catalytic triad [active]
548476002927	Transposase [DNA replication, recombination, and repair]; Region: COG5421
548476002928	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548476002929	Major Facilitator Superfamily; Region: MFS_1; pfam07690
548476002930	putative substrate translocation pore; other site
548476002931	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203
548476002932	PLD-like domain; Region: PLDc_2; pfam13091
548476002933	putative homodimer interface [polypeptide binding]; other site
548476002934	putative active site [active]
548476002935	catalytic site [active]
548476002936	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
548476002937	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
548476002938	putative Mg++ binding site [ion binding]; other site
548476002939	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
548476002940	nucleotide binding region [chemical binding]; other site
548476002941	ATP-binding site [chemical binding]; other site
548476002942	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
548476002943	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
548476002944	active site
548476002945	8-oxo-dGMP binding site [chemical binding]; other site
548476002946	nudix motif; other site
548476002947	metal binding site [ion binding]; metal-binding site
548476002948	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
548476002949	putative active site [active]
548476002950	putative metal binding site [ion binding]; other site
548476002951	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
548476002952	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
548476002953	Nucleoside recognition; Region: Gate; pfam07670
548476002954	Transcriptional regulator [Transcription]; Region: IclR; COG1414
548476002955	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
548476002956	Bacterial transcriptional regulator; Region: IclR; pfam01614
548476002957	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
548476002958	active sites [active]
548476002959	tetramer interface [polypeptide binding]; other site
548476002960	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
548476002961	urocanate hydratase; Provisional; Region: PRK05414
548476002962	imidazolonepropionase; Provisional; Region: PRK14085
548476002963	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
548476002964	active site
548476002965	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
548476002966	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
548476002967	ATP binding site [chemical binding]; other site
548476002968	Mg++ binding site [ion binding]; other site
548476002969	motif III; other site
548476002970	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
548476002971	nucleotide binding region [chemical binding]; other site
548476002972	ATP-binding site [chemical binding]; other site
548476002973	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
548476002974	putative RNA binding site [nucleotide binding]; other site
548476002975	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
548476002976	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
548476002977	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
548476002978	Na binding site [ion binding]; other site
548476002979	SNF2 Helicase protein; Region: DUF3670; pfam12419
548476002980	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
548476002981	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
548476002982	putative Mg++ binding site [ion binding]; other site
548476002983	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
548476002984	nucleotide binding region [chemical binding]; other site
548476002985	ATP-binding site [chemical binding]; other site
548476002986	Uncharacterized conserved protein [Function unknown]; Region: COG4279
548476002987	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
548476002988	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
548476002989	active site
548476002990	metal binding site [ion binding]; metal-binding site
548476002991	DNA binding site [nucleotide binding]
548476002992	AAA domain; Region: AAA_23; pfam13476
548476002993	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548476002994	Walker A/P-loop; other site
548476002995	ATP binding site [chemical binding]; other site
548476002996	Transcriptional regulators [Transcription]; Region: MarR; COG1846
548476002997	MarR family; Region: MarR_2; pfam12802
548476002998	TAP-like protein; Region: Abhydrolase_4; pfam08386
548476002999	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
548476003000	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
548476003001	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
548476003002	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
548476003003	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
548476003004	Cysteine-rich domain; Region: CCG; pfam02754
548476003005	Cysteine-rich domain; Region: CCG; pfam02754
548476003006	L-lactate permease; Region: Lactate_perm; cl00701
548476003007	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
548476003008	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
548476003009	L-lactate permease; Region: Lactate_perm; cl00701
548476003010	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
548476003011	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
548476003012	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
548476003013	active site
548476003014	HIGH motif; other site
548476003015	KMSK motif region; other site
548476003016	DALR anticodon binding domain; Region: DALR_1; smart00836
548476003017	anticodon binding site; other site
548476003018	tRNA binding surface [nucleotide binding]; other site
548476003019	diaminopimelate decarboxylase; Region: lysA; TIGR01048
548476003020	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
548476003021	active site
548476003022	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
548476003023	substrate binding site [chemical binding]; other site
548476003024	catalytic residues [active]
548476003025	dimer interface [polypeptide binding]; other site
548476003026	homoserine dehydrogenase; Provisional; Region: PRK06349
548476003027	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
548476003028	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
548476003029	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
548476003030	homoserine kinase; Provisional; Region: PRK01212
548476003031	Predicted transcriptional regulator [Transcription]; Region: COG2345
548476003032	Helix-turn-helix domain; Region: HTH_20; pfam12840
548476003033	putative DNA binding site [nucleotide binding]; other site
548476003034	putative Zn2+ binding site [ion binding]; other site
548476003035	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
548476003036	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548476003037	putative PBP binding loops; other site
548476003038	dimer interface [polypeptide binding]; other site
548476003039	ABC-ATPase subunit interface; other site
548476003040	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
548476003041	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548476003042	Walker A/P-loop; other site
548476003043	ATP binding site [chemical binding]; other site
548476003044	Q-loop/lid; other site
548476003045	ABC transporter signature motif; other site
548476003046	Walker B; other site
548476003047	D-loop; other site
548476003048	H-loop/switch region; other site
548476003049	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
548476003050	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
548476003051	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
548476003052	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
548476003053	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
548476003054	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
548476003055	GTP binding site; other site
548476003056	MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242
548476003057	trimer interface [polypeptide binding]; other site
548476003058	dimer interface [polypeptide binding]; other site
548476003059	putative active site [active]
548476003060	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
548476003061	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
548476003062	dimer interface [polypeptide binding]; other site
548476003063	putative functional site; other site
548476003064	putative MPT binding site; other site
548476003065	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
548476003066	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
548476003067	FeS/SAM binding site; other site
548476003068	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
548476003069	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620
548476003070	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
548476003071	acyl-activating enzyme (AAE) consensus motif; other site
548476003072	AMP binding site [chemical binding]; other site
548476003073	active site
548476003074	CoA binding site [chemical binding]; other site
548476003075	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
548476003076	transcription termination factor Rho; Provisional; Region: PRK12608
548476003077	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
548476003078	RNA binding site [nucleotide binding]; other site
548476003079	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
548476003080	multimer interface [polypeptide binding]; other site
548476003081	Walker A motif; other site
548476003082	ATP binding site [chemical binding]; other site
548476003083	Walker B motif; other site
548476003084	peptide chain release factor 1; Validated; Region: prfA; PRK00591
548476003085	This domain is found in peptide chain release factors; Region: PCRF; smart00937
548476003086	RF-1 domain; Region: RF-1; pfam00472
548476003087	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
548476003088	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548476003089	S-adenosylmethionine binding site [chemical binding]; other site
548476003090	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
548476003091	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
548476003092	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
548476003093	Mg++ binding site [ion binding]; other site
548476003094	putative catalytic motif [active]
548476003095	substrate binding site [chemical binding]; other site
548476003096	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
548476003097	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
548476003098	F0F1 ATP synthase subunit C; Validated; Region: PRK07874
548476003099	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
548476003100	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
548476003101	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
548476003102	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
548476003103	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
548476003104	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
548476003105	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
548476003106	beta subunit interaction interface [polypeptide binding]; other site
548476003107	Walker A motif; other site
548476003108	ATP binding site [chemical binding]; other site
548476003109	Walker B motif; other site
548476003110	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
548476003111	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
548476003112	core domain interface [polypeptide binding]; other site
548476003113	delta subunit interface [polypeptide binding]; other site
548476003114	epsilon subunit interface [polypeptide binding]; other site
548476003115	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
548476003116	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
548476003117	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
548476003118	alpha subunit interaction interface [polypeptide binding]; other site
548476003119	Walker A motif; other site
548476003120	ATP binding site [chemical binding]; other site
548476003121	Walker B motif; other site
548476003122	inhibitor binding site; inhibition site
548476003123	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
548476003124	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
548476003125	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
548476003126	gamma subunit interface [polypeptide binding]; other site
548476003127	epsilon subunit interface [polypeptide binding]; other site
548476003128	LBP interface [polypeptide binding]; other site
548476003129	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
548476003130	Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637
548476003131	hypothetical protein; Provisional; Region: PRK03298
548476003132	Domain of unknown function DUF77; Region: DUF77; pfam01910
548476003133	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
548476003134	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
548476003135	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
548476003136	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
548476003137	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
548476003138	Low molecular weight phosphatase family; Region: LMWPc; cl00105
548476003139	active site
548476003140	glycogen branching enzyme; Provisional; Region: PRK05402
548476003141	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
548476003142	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
548476003143	active site
548476003144	catalytic site [active]
548476003145	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
548476003146	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
548476003147	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
548476003148	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
548476003149	active site
548476003150	catalytic site [active]
548476003151	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
548476003152	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548476003153	Walker A/P-loop; other site
548476003154	ATP binding site [chemical binding]; other site
548476003155	Q-loop/lid; other site
548476003156	ABC transporter signature motif; other site
548476003157	Walker B; other site
548476003158	D-loop; other site
548476003159	H-loop/switch region; other site
548476003160	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
548476003161	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
548476003162	Ligand binding site [chemical binding]; other site
548476003163	Electron transfer flavoprotein domain; Region: ETF; pfam01012
548476003164	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
548476003165	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
548476003166	Ligand Binding Site [chemical binding]; other site
548476003167	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
548476003168	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
548476003169	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
548476003170	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
548476003171	catalytic residue [active]
548476003172	Putative esterase; Region: Esterase; pfam00756
548476003173	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
548476003174	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
548476003175	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
548476003176	active site
548476003177	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548476003178	S-adenosylmethionine binding site [chemical binding]; other site
548476003179	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
548476003180	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
548476003181	Ligand Binding Site [chemical binding]; other site
548476003182	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
548476003183	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
548476003184	putative active site [active]
548476003185	homotetrameric interface [polypeptide binding]; other site
548476003186	metal binding site [ion binding]; metal-binding site
548476003187	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
548476003188	Beta-lactamase; Region: Beta-lactamase; pfam00144
548476003189	Helix-turn-helix domain; Region: HTH_20; pfam12840
548476003190	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
548476003191	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
548476003192	active site
548476003193	catalytic site [active]
548476003194	substrate binding site [chemical binding]; other site
548476003195	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
548476003196	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
548476003197	nucleotide binding pocket [chemical binding]; other site
548476003198	K-X-D-G motif; other site
548476003199	catalytic site [active]
548476003200	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
548476003201	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
548476003202	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
548476003203	Dimer interface [polypeptide binding]; other site
548476003204	BRCT sequence motif; other site
548476003205	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548476003206	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
548476003207	active site
548476003208	motif I; other site
548476003209	motif II; other site
548476003210	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
548476003211	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
548476003212	active site
548476003213	motif I; other site
548476003214	motif II; other site
548476003215	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
548476003216	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
548476003217	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
548476003218	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
548476003219	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
548476003220	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
548476003221	active site
548476003222	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548476003223	Major Facilitator Superfamily; Region: MFS_1; pfam07690
548476003224	putative substrate translocation pore; other site
548476003225	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
548476003226	phosphofructokinase; Region: PFK_mixed; TIGR02483
548476003227	active site
548476003228	ADP/pyrophosphate binding site [chemical binding]; other site
548476003229	dimerization interface [polypeptide binding]; other site
548476003230	allosteric effector site; other site
548476003231	fructose-1,6-bisphosphate binding site; other site
548476003232	putative transporter; Validated; Region: PRK03818
548476003233	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
548476003234	TrkA-C domain; Region: TrkA_C; pfam02080
548476003235	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
548476003236	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
548476003237	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
548476003238	GatB domain; Region: GatB_Yqey; smart00845
548476003239	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
548476003240	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
548476003241	putative NAD(P) binding site [chemical binding]; other site
548476003242	putative substrate binding site [chemical binding]; other site
548476003243	catalytic Zn binding site [ion binding]; other site
548476003244	structural Zn binding site [ion binding]; other site
548476003245	dimer interface [polypeptide binding]; other site
548476003246	Uncharacterized membrane protein [Function unknown]; Region: COG3949
548476003247	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
548476003248	Lysine efflux permease [General function prediction only]; Region: COG1279
548476003249	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
548476003250	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
548476003251	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
548476003252	dimerization interface [polypeptide binding]; other site
548476003253	Predicted membrane protein [Function unknown]; Region: COG2259
548476003254	Transposase; Region: DEDD_Tnp_IS110; pfam01548
548476003255	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
548476003256	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
548476003257	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
548476003258	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
548476003259	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
548476003260	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
548476003261	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
548476003262	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
548476003263	PYR/PP interface [polypeptide binding]; other site
548476003264	dimer interface [polypeptide binding]; other site
548476003265	TPP binding site [chemical binding]; other site
548476003266	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
548476003267	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
548476003268	TPP-binding site [chemical binding]; other site
548476003269	dimer interface [polypeptide binding]; other site
548476003270	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
548476003271	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
548476003272	putative valine binding site [chemical binding]; other site
548476003273	dimer interface [polypeptide binding]; other site
548476003274	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
548476003275	ketol-acid reductoisomerase; Provisional; Region: PRK05479
548476003276	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
548476003277	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
548476003278	Uncharacterized conserved protein [Function unknown]; Region: COG1479
548476003279	Protein of unknown function DUF262; Region: DUF262; pfam03235
548476003280	Uncharacterized conserved protein [Function unknown]; Region: COG3472
548476003281	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
548476003282	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
548476003283	ligand binding site [chemical binding]; other site
548476003284	NAD binding site [chemical binding]; other site
548476003285	dimerization interface [polypeptide binding]; other site
548476003286	catalytic site [active]
548476003287	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
548476003288	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
548476003289	tartrate dehydrogenase; Region: TTC; TIGR02089
548476003290	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
548476003291	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
548476003292	ligand binding site [chemical binding]; other site
548476003293	flexible hinge region; other site
548476003294	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
548476003295	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
548476003296	metal binding triad; other site
548476003297	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
548476003298	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
548476003299	active site
548476003300	catalytic site [active]
548476003301	substrate binding site [chemical binding]; other site
548476003302	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
548476003303	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
548476003304	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
548476003305	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
548476003306	putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773
548476003307	translation initiation factor IF-2; Validated; Region: infB; PRK05306
548476003308	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
548476003309	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
548476003310	ABC-ATPase subunit  interface; other site
548476003311	dimer interface [polypeptide binding]; other site
548476003312	putative PBP binding regions; other site
548476003313	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
548476003314	anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771
548476003315	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
548476003316	anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772
548476003317	intersubunit interface [polypeptide binding]; other site
548476003318	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
548476003319	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
548476003320	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
548476003321	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
548476003322	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
548476003323	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
548476003324	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
548476003325	active site
548476003326	HIGH motif; other site
548476003327	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
548476003328	active site
548476003329	KMSKS motif; other site
548476003330	MarR family; Region: MarR_2; cl17246
548476003331	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
548476003332	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
548476003333	Transcriptional regulator [Transcription]; Region: IclR; COG1414
548476003334	Bacterial transcriptional regulator; Region: IclR; pfam01614
548476003335	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
548476003336	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
548476003337	substrate binding site [chemical binding]; other site
548476003338	ligand binding site [chemical binding]; other site
548476003339	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
548476003340	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
548476003341	substrate binding site [chemical binding]; other site
548476003342	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
548476003343	active site
548476003344	Ap6A binding site [chemical binding]; other site
548476003345	nudix motif; other site
548476003346	metal binding site [ion binding]; metal-binding site
548476003347	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
548476003348	catalytic core [active]
548476003349	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
548476003350	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
548476003351	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
548476003352	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
548476003353	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
548476003354	ATP-grasp domain; Region: ATP-grasp_4; cl17255
548476003355	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
548476003356	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
548476003357	thiamine monophosphate kinase; Provisional; Region: PRK05731
548476003358	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
548476003359	ATP binding site [chemical binding]; other site
548476003360	dimerization interface [polypeptide binding]; other site
548476003361	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
548476003362	ligand binding site [chemical binding]; other site
548476003363	active site
548476003364	UGI interface [polypeptide binding]; other site
548476003365	catalytic site [active]
548476003366	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
548476003367	DAK2 domain; Region: Dak2; pfam02734
548476003368	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
548476003369	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
548476003370	generic binding surface II; other site
548476003371	ssDNA binding site; other site
548476003372	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
548476003373	ATP binding site [chemical binding]; other site
548476003374	putative Mg++ binding site [ion binding]; other site
548476003375	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
548476003376	nucleotide binding region [chemical binding]; other site
548476003377	ATP-binding site [chemical binding]; other site
548476003378	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
548476003379	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
548476003380	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
548476003381	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
548476003382	active site
548476003383	(T/H)XGH motif; other site
548476003384	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
548476003385	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
548476003386	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
548476003387	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
548476003388	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
548476003389	putative hydrophobic ligand binding site [chemical binding]; other site
548476003390	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
548476003391	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
548476003392	NAD(P) binding site [chemical binding]; other site
548476003393	active site
548476003394	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
548476003395	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
548476003396	active site
548476003397	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
548476003398	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
548476003399	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
548476003400	dihydroorotase; Validated; Region: pyrC; PRK09357
548476003401	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
548476003402	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
548476003403	active site
548476003404	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
548476003405	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
548476003406	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
548476003407	catalytic site [active]
548476003408	subunit interface [polypeptide binding]; other site
548476003409	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
548476003410	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
548476003411	ATP-grasp domain; Region: ATP-grasp_4; cl17255
548476003412	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
548476003413	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
548476003414	ATP-grasp domain; Region: ATP-grasp_4; cl17255
548476003415	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
548476003416	IMP binding site; other site
548476003417	dimer interface [polypeptide binding]; other site
548476003418	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
548476003419	active site
548476003420	dimer interface [polypeptide binding]; other site
548476003421	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
548476003422	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
548476003423	catalytic site [active]
548476003424	G-X2-G-X-G-K; other site
548476003425	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
548476003426	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
548476003427	Flavoprotein; Region: Flavoprotein; pfam02441
548476003428	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
548476003429	S-adenosylmethionine synthetase; Validated; Region: PRK05250
548476003430	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
548476003431	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
548476003432	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
548476003433	primosome assembly protein PriA; Provisional; Region: PRK14873
548476003434	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
548476003435	active site
548476003436	catalytic residues [active]
548476003437	metal binding site [ion binding]; metal-binding site
548476003438	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
548476003439	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
548476003440	putative active site [active]
548476003441	substrate binding site [chemical binding]; other site
548476003442	putative cosubstrate binding site; other site
548476003443	catalytic site [active]
548476003444	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
548476003445	substrate binding site [chemical binding]; other site
548476003446	16S rRNA methyltransferase B; Provisional; Region: PRK14902
548476003447	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
548476003448	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548476003449	S-adenosylmethionine binding site [chemical binding]; other site
548476003450	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
548476003451	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
548476003452	substrate binding site [chemical binding]; other site
548476003453	hexamer interface [polypeptide binding]; other site
548476003454	metal binding site [ion binding]; metal-binding site
548476003455	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
548476003456	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
548476003457	catalytic motif [active]
548476003458	Zn binding site [ion binding]; other site
548476003459	RibD C-terminal domain; Region: RibD_C; pfam01872
548476003460	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
548476003461	Lumazine binding domain; Region: Lum_binding; pfam00677
548476003462	Lumazine binding domain; Region: Lum_binding; pfam00677
548476003463	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
548476003464	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
548476003465	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
548476003466	dimerization interface [polypeptide binding]; other site
548476003467	active site
548476003468	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
548476003469	homopentamer interface [polypeptide binding]; other site
548476003470	active site
548476003471	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
548476003472	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
548476003473	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
548476003474	GIY-YIG motif/motif A; other site
548476003475	active site
548476003476	catalytic site [active]
548476003477	putative DNA binding site [nucleotide binding]; other site
548476003478	metal binding site [ion binding]; metal-binding site
548476003479	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
548476003480	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
548476003481	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
548476003482	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
548476003483	phosphate binding site [ion binding]; other site
548476003484	putative substrate binding pocket [chemical binding]; other site
548476003485	dimer interface [polypeptide binding]; other site
548476003486	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
548476003487	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
548476003488	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
548476003489	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
548476003490	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
548476003491	Phosphoglycerate kinase; Region: PGK; pfam00162
548476003492	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
548476003493	substrate binding site [chemical binding]; other site
548476003494	hinge regions; other site
548476003495	ADP binding site [chemical binding]; other site
548476003496	catalytic site [active]
548476003497	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
548476003498	triosephosphate isomerase; Provisional; Region: PRK14567
548476003499	substrate binding site [chemical binding]; other site
548476003500	dimer interface [polypeptide binding]; other site
548476003501	catalytic triad [active]
548476003502	Preprotein translocase SecG subunit; Region: SecG; cl09123
548476003503	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
548476003504	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
548476003505	putative active site [active]
548476003506	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
548476003507	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
548476003508	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
548476003509	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
548476003510	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
548476003511	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
548476003512	putative active site [active]
548476003513	transaldolase; Provisional; Region: PRK03903
548476003514	catalytic residue [active]
548476003515	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
548476003516	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
548476003517	TPP-binding site [chemical binding]; other site
548476003518	dimer interface [polypeptide binding]; other site
548476003519	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
548476003520	PYR/PP interface [polypeptide binding]; other site
548476003521	dimer interface [polypeptide binding]; other site
548476003522	TPP binding site [chemical binding]; other site
548476003523	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
548476003524	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
548476003525	UbiA prenyltransferase family; Region: UbiA; pfam01040
548476003526	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
548476003527	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
548476003528	NADP binding site [chemical binding]; other site
548476003529	dimer interface [polypeptide binding]; other site
548476003530	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
548476003531	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
548476003532	ABC-2 type transporter; Region: ABC2_membrane; cl17235
548476003533	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
548476003534	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
548476003535	Walker A/P-loop; other site
548476003536	ATP binding site [chemical binding]; other site
548476003537	Q-loop/lid; other site
548476003538	ABC transporter signature motif; other site
548476003539	Walker B; other site
548476003540	D-loop; other site
548476003541	H-loop/switch region; other site
548476003542	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
548476003543	Predicted transcriptional regulator [Transcription]; Region: COG2345
548476003544	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
548476003545	putative DNA binding site [nucleotide binding]; other site
548476003546	putative Zn2+ binding site [ion binding]; other site
548476003547	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
548476003548	FeS assembly protein SufB; Region: sufB; TIGR01980
548476003549	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
548476003550	FeS assembly protein SufD; Region: sufD; TIGR01981
548476003551	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
548476003552	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
548476003553	Walker A/P-loop; other site
548476003554	ATP binding site [chemical binding]; other site
548476003555	Q-loop/lid; other site
548476003556	ABC transporter signature motif; other site
548476003557	Walker B; other site
548476003558	D-loop; other site
548476003559	H-loop/switch region; other site
548476003560	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
548476003561	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
548476003562	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
548476003563	catalytic residue [active]
548476003564	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
548476003565	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
548476003566	trimerization site [polypeptide binding]; other site
548476003567	active site
548476003568	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
548476003569	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
548476003570	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
548476003571	active site
548476003572	P-loop; other site
548476003573	phosphorylation site [posttranslational modification]
548476003574	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
548476003575	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
548476003576	active site
548476003577	phosphorylation site [posttranslational modification]
548476003578	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
548476003579	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
548476003580	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548476003581	Walker A/P-loop; other site
548476003582	ATP binding site [chemical binding]; other site
548476003583	Q-loop/lid; other site
548476003584	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
548476003585	ABC transporter signature motif; other site
548476003586	Walker B; other site
548476003587	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
548476003588	Winged helix-turn helix; Region: HTH_29; pfam13551
548476003589	Helix-turn-helix domain; Region: HTH_28; pfam13518
548476003590	Integrase core domain; Region: rve; pfam00665
548476003591	putative transposase OrfB; Reviewed; Region: PHA02517
548476003592	HTH-like domain; Region: HTH_21; pfam13276
548476003593	Integrase core domain; Region: rve; pfam00665
548476003594	Integrase core domain; Region: rve_3; pfam13683
548476003595	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548476003596	Transposase; Region: HTH_Tnp_1; pfam01527
548476003597	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
548476003598	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
548476003599	DNA binding residues [nucleotide binding]
548476003600	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
548476003601	hypothetical protein; Validated; Region: PRK00194
548476003602	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
548476003603	NADH(P)-binding; Region: NAD_binding_10; pfam13460
548476003604	NAD(P) binding site [chemical binding]; other site
548476003605	active site
548476003606	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
548476003607	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
548476003608	aconitate hydratase; Validated; Region: PRK09277
548476003609	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
548476003610	substrate binding site [chemical binding]; other site
548476003611	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
548476003612	ligand binding site [chemical binding]; other site
548476003613	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
548476003614	substrate binding site [chemical binding]; other site
548476003615	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
548476003616	NlpC/P60 family; Region: NLPC_P60; pfam00877
548476003617	ferrochelatase; Reviewed; Region: hemH; PRK00035
548476003618	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
548476003619	C-terminal domain interface [polypeptide binding]; other site
548476003620	active site
548476003621	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
548476003622	active site
548476003623	N-terminal domain interface [polypeptide binding]; other site
548476003624	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
548476003625	Uncharacterized conserved protein [Function unknown]; Region: COG0398
548476003626	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
548476003627	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
548476003628	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
548476003629	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
548476003630	Helix-turn-helix domain; Region: HTH_28; pfam13518
548476003631	MULE transposase domain; Region: MULE; pfam10551
548476003632	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
548476003633	substrate binding site [chemical binding]; other site
548476003634	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
548476003635	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
548476003636	quinone interaction residues [chemical binding]; other site
548476003637	active site
548476003638	catalytic residues [active]
548476003639	FMN binding site [chemical binding]; other site
548476003640	substrate binding site [chemical binding]; other site
548476003641	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
548476003642	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
548476003643	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
548476003644	active site
548476003645	HIGH motif; other site
548476003646	nucleotide binding site [chemical binding]; other site
548476003647	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
548476003648	active site
548476003649	KMSKS motif; other site
548476003650	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
548476003651	tRNA binding surface [nucleotide binding]; other site
548476003652	anticodon binding site; other site
548476003653	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
548476003654	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548476003655	motif II; other site
548476003656	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
548476003657	homodimer interface [polypeptide binding]; other site
548476003658	putative metal binding site [ion binding]; other site
548476003659	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
548476003660	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
548476003661	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
548476003662	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
548476003663	Aspartase; Region: Aspartase; cd01357
548476003664	active sites [active]
548476003665	tetramer interface [polypeptide binding]; other site
548476003666	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
548476003667	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
548476003668	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
548476003669	Potassium binding sites [ion binding]; other site
548476003670	Cesium cation binding sites [ion binding]; other site
548476003671	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
548476003672	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
548476003673	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
548476003674	active site
548476003675	metal binding site [ion binding]; metal-binding site
548476003676	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
548476003677	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548476003678	S-adenosylmethionine binding site [chemical binding]; other site
548476003679	proteasome ATPase; Region: pup_AAA; TIGR03689
548476003680	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548476003681	Walker A motif; other site
548476003682	ATP binding site [chemical binding]; other site
548476003683	Walker B motif; other site
548476003684	arginine finger; other site
548476003685	proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688
548476003686	Pup-like protein; Region: Pup; pfam05639
548476003687	Pup-ligase protein; Region: Pup_ligase; cl15463
548476003688	WYL domain; Region: WYL; pfam13280
548476003689	Predicted transcriptional regulator [Transcription]; Region: COG2378
548476003690	WYL domain; Region: WYL; pfam13280
548476003691	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
548476003692	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
548476003693	Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902
548476003694	DEAD-like helicases superfamily; Region: DEXDc; smart00487
548476003695	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
548476003696	ATP binding site [chemical binding]; other site
548476003697	putative Mg++ binding site [ion binding]; other site
548476003698	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
548476003699	nucleotide binding region [chemical binding]; other site
548476003700	ATP-binding site [chemical binding]; other site
548476003701	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
548476003702	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
548476003703	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
548476003704	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
548476003705	active site
548476003706	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
548476003707	hypothetical protein; Provisional; Region: PRK05599
548476003708	NAD(P) binding site [chemical binding]; other site
548476003709	active site
548476003710	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
548476003711	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
548476003712	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
548476003713	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
548476003714	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
548476003715	putative active site [active]
548476003716	catalytic triad [active]
548476003717	putative dimer interface [polypeptide binding]; other site
548476003718	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
548476003719	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
548476003720	Ligand binding site; other site
548476003721	Putative Catalytic site; other site
548476003722	DXD motif; other site
548476003723	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
548476003724	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
548476003725	Walker A/P-loop; other site
548476003726	ATP binding site [chemical binding]; other site
548476003727	Q-loop/lid; other site
548476003728	ABC transporter signature motif; other site
548476003729	Walker B; other site
548476003730	D-loop; other site
548476003731	H-loop/switch region; other site
548476003732	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
548476003733	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
548476003734	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
548476003735	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
548476003736	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548476003737	dimer interface [polypeptide binding]; other site
548476003738	conserved gate region; other site
548476003739	putative PBP binding loops; other site
548476003740	ABC-ATPase subunit interface; other site
548476003741	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
548476003742	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548476003743	dimer interface [polypeptide binding]; other site
548476003744	conserved gate region; other site
548476003745	putative PBP binding loops; other site
548476003746	ABC-ATPase subunit interface; other site
548476003747	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
548476003748	YceI-like domain; Region: YceI; pfam04264
548476003749	metabolite-proton symporter; Region: 2A0106; TIGR00883
548476003750	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548476003751	putative substrate translocation pore; other site
548476003752	bile acid transporter; Region: bass; TIGR00841
548476003753	Sodium Bile acid symporter family; Region: SBF; pfam01758
548476003754	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
548476003755	FAD binding domain; Region: FAD_binding_4; pfam01565
548476003756	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
548476003757	Cysteine-rich domain; Region: CCG; pfam02754
548476003758	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
548476003759	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
548476003760	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
548476003761	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
548476003762	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
548476003763	dimer interface [polypeptide binding]; other site
548476003764	substrate binding site [chemical binding]; other site
548476003765	ATP binding site [chemical binding]; other site
548476003766	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548476003767	Methyltransferase domain; Region: Methyltransf_31; pfam13847
548476003768	S-adenosylmethionine binding site [chemical binding]; other site
548476003769	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
548476003770	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
548476003771	oligomer interface [polypeptide binding]; other site
548476003772	metal binding site [ion binding]; metal-binding site
548476003773	metal binding site [ion binding]; metal-binding site
548476003774	putative Cl binding site [ion binding]; other site
548476003775	basic sphincter; other site
548476003776	hydrophobic gate; other site
548476003777	periplasmic entrance; other site
548476003778	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
548476003779	CoenzymeA binding site [chemical binding]; other site
548476003780	subunit interaction site [polypeptide binding]; other site
548476003781	PHB binding site; other site
548476003782	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
548476003783	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
548476003784	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
548476003785	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
548476003786	active site
548476003787	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
548476003788	DEAD-like helicases superfamily; Region: DEXDc; smart00487
548476003789	ATP binding site [chemical binding]; other site
548476003790	Mg++ binding site [ion binding]; other site
548476003791	motif III; other site
548476003792	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
548476003793	nucleotide binding region [chemical binding]; other site
548476003794	ATP-binding site [chemical binding]; other site
548476003795	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
548476003796	metal ion-dependent adhesion site (MIDAS); other site
548476003797	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
548476003798	DNA binding residues [nucleotide binding]
548476003799	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
548476003800	putative dimer interface [polypeptide binding]; other site
548476003801	Bifunctional nuclease; Region: DNase-RNase; cl00553
548476003802	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
548476003803	DNA binding residues [nucleotide binding]
548476003804	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
548476003805	dimer interface [polypeptide binding]; other site
548476003806	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
548476003807	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
548476003808	phosphopeptide binding site; other site
548476003809	preprotein translocase subunit SecA; Reviewed; Region: PRK12326
548476003810	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
548476003811	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
548476003812	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
548476003813	nucleotide binding region [chemical binding]; other site
548476003814	ATP-binding site [chemical binding]; other site
548476003815	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
548476003816	OsmC-like protein; Region: OsmC; pfam02566
548476003817	hypothetical protein; Provisional; Region: PRK04233
548476003818	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
548476003819	dimer interface [polypeptide binding]; other site
548476003820	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
548476003821	WHG domain; Region: WHG; pfam13305
548476003822	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
548476003823	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
548476003824	DNA methylase; Region: N6_N4_Mtase; pfam01555
548476003825	DNA methylase; Region: N6_N4_Mtase; cl17433
548476003826	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
548476003827	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548476003828	S-adenosylmethionine binding site [chemical binding]; other site
548476003829	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
548476003830	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
548476003831	Walker A/P-loop; other site
548476003832	ATP binding site [chemical binding]; other site
548476003833	Q-loop/lid; other site
548476003834	ABC transporter signature motif; other site
548476003835	Walker B; other site
548476003836	D-loop; other site
548476003837	H-loop/switch region; other site
548476003838	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
548476003839	Histidine kinase; Region: HisKA_3; pfam07730
548476003840	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
548476003841	Mg2+ binding site [ion binding]; other site
548476003842	G-X-G motif; other site
548476003843	DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360
548476003844	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548476003845	active site
548476003846	phosphorylation site [posttranslational modification]
548476003847	intermolecular recognition site; other site
548476003848	dimerization interface [polypeptide binding]; other site
548476003849	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
548476003850	DNA binding residues [nucleotide binding]
548476003851	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
548476003852	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
548476003853	GTP-binding protein Der; Reviewed; Region: PRK03003
548476003854	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
548476003855	G1 box; other site
548476003856	GTP/Mg2+ binding site [chemical binding]; other site
548476003857	Switch I region; other site
548476003858	G2 box; other site
548476003859	Switch II region; other site
548476003860	G3 box; other site
548476003861	G4 box; other site
548476003862	G5 box; other site
548476003863	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
548476003864	G1 box; other site
548476003865	GTP/Mg2+ binding site [chemical binding]; other site
548476003866	Switch I region; other site
548476003867	G2 box; other site
548476003868	G3 box; other site
548476003869	Switch II region; other site
548476003870	G4 box; other site
548476003871	G5 box; other site
548476003872	cytidylate kinase; Provisional; Region: cmk; PRK00023
548476003873	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
548476003874	CMP-binding site; other site
548476003875	The sites determining sugar specificity; other site
548476003876	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
548476003877	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
548476003878	RNA binding surface [nucleotide binding]; other site
548476003879	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
548476003880	active site
548476003881	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
548476003882	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
548476003883	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
548476003884	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
548476003885	P-loop; other site
548476003886	Magnesium ion binding site [ion binding]; other site
548476003887	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
548476003888	Magnesium ion binding site [ion binding]; other site
548476003889	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
548476003890	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
548476003891	active site
548476003892	Int/Topo IB signature motif; other site
548476003893	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
548476003894	dimer interface [polypeptide binding]; other site
548476003895	ADP-ribose binding site [chemical binding]; other site
548476003896	active site
548476003897	nudix motif; other site
548476003898	metal binding site [ion binding]; metal-binding site
548476003899	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
548476003900	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
548476003901	Protein of unknown function DUF115; Region: MAF_flag10; cl17471
548476003902	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
548476003903	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
548476003904	Walker A/P-loop; other site
548476003905	ATP binding site [chemical binding]; other site
548476003906	Q-loop/lid; other site
548476003907	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
548476003908	ABC transporter signature motif; other site
548476003909	Walker B; other site
548476003910	D-loop; other site
548476003911	H-loop/switch region; other site
548476003912	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
548476003913	ATP-NAD kinase; Region: NAD_kinase; pfam01513
548476003914	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
548476003915	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
548476003916	RNA binding surface [nucleotide binding]; other site
548476003917	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548476003918	S-adenosylmethionine binding site [chemical binding]; other site
548476003919	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
548476003920	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548476003921	active site
548476003922	motif I; other site
548476003923	motif II; other site
548476003924	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548476003925	putative transposase OrfB; Reviewed; Region: PHA02517
548476003926	HTH-like domain; Region: HTH_21; pfam13276
548476003927	Integrase core domain; Region: rve; pfam00665
548476003928	Integrase core domain; Region: rve_3; pfam13683
548476003929	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548476003930	Transposase; Region: HTH_Tnp_1; pfam01527
548476003931	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
548476003932	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
548476003933	active site
548476003934	HIGH motif; other site
548476003935	dimer interface [polypeptide binding]; other site
548476003936	KMSKS motif; other site
548476003937	S4 RNA-binding domain; Region: S4; smart00363
548476003938	RNA binding surface [nucleotide binding]; other site
548476003939	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
548476003940	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
548476003941	metal ion-dependent adhesion site (MIDAS); other site
548476003942	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
548476003943	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
548476003944	L-asparagine permease; Provisional; Region: PRK15049
548476003945	argininosuccinate lyase; Provisional; Region: PRK00855
548476003946	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
548476003947	active sites [active]
548476003948	tetramer interface [polypeptide binding]; other site
548476003949	argininosuccinate synthase; Provisional; Region: PRK13820
548476003950	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
548476003951	ANP binding site [chemical binding]; other site
548476003952	Substrate Binding Site II [chemical binding]; other site
548476003953	Substrate Binding Site I [chemical binding]; other site
548476003954	arginine repressor; Provisional; Region: PRK03341
548476003955	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
548476003956	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
548476003957	ornithine carbamoyltransferase; Provisional; Region: PRK00779
548476003958	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
548476003959	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
548476003960	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
548476003961	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
548476003962	inhibitor-cofactor binding pocket; inhibition site
548476003963	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548476003964	catalytic residue [active]
548476003965	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
548476003966	feedback inhibition sensing region; other site
548476003967	homohexameric interface [polypeptide binding]; other site
548476003968	nucleotide binding site [chemical binding]; other site
548476003969	N-acetyl-L-glutamate binding site [chemical binding]; other site
548476003970	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
548476003971	heterotetramer interface [polypeptide binding]; other site
548476003972	active site pocket [active]
548476003973	cleavage site
548476003974	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
548476003975	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
548476003976	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
548476003977	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
548476003978	putative tRNA-binding site [nucleotide binding]; other site
548476003979	B3/4 domain; Region: B3_4; pfam03483
548476003980	tRNA synthetase B5 domain; Region: B5; smart00874
548476003981	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
548476003982	dimer interface [polypeptide binding]; other site
548476003983	motif 1; other site
548476003984	motif 3; other site
548476003985	motif 2; other site
548476003986	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
548476003987	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
548476003988	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
548476003989	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
548476003990	dimer interface [polypeptide binding]; other site
548476003991	motif 1; other site
548476003992	active site
548476003993	motif 2; other site
548476003994	motif 3; other site
548476003995	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
548476003996	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
548476003997	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
548476003998	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
548476003999	23S rRNA binding site [nucleotide binding]; other site
548476004000	L21 binding site [polypeptide binding]; other site
548476004001	L13 binding site [polypeptide binding]; other site
548476004002	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
548476004003	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
548476004004	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
548476004005	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
548476004006	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
548476004007	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
548476004008	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
548476004009	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
548476004010	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
548476004011	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
548476004012	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
548476004013	Part of AAA domain; Region: AAA_19; pfam13245
548476004014	ACT domain; Region: ACT_3; pfam10000
548476004015	Family description; Region: UvrD_C_2; pfam13538
548476004016	Uncharacterized conserved protein [Function unknown]; Region: COG4850
548476004017	Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949
548476004018	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
548476004019	Ligand Binding Site [chemical binding]; other site
548476004020	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
548476004021	Ligand Binding Site [chemical binding]; other site
548476004022	excinuclease ABC subunit B; Provisional; Region: PRK05298
548476004023	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
548476004024	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
548476004025	nucleotide binding region [chemical binding]; other site
548476004026	ATP-binding site [chemical binding]; other site
548476004027	Ultra-violet resistance protein B; Region: UvrB; pfam12344
548476004028	UvrB/uvrC motif; Region: UVR; pfam02151
548476004029	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
548476004030	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
548476004031	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
548476004032	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
548476004033	CoA-binding site [chemical binding]; other site
548476004034	ATP-binding [chemical binding]; other site
548476004035	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
548476004036	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
548476004037	RNA binding site [nucleotide binding]; other site
548476004038	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
548476004039	RNA binding site [nucleotide binding]; other site
548476004040	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
548476004041	RNA binding site [nucleotide binding]; other site
548476004042	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
548476004043	RNA binding site [nucleotide binding]; other site
548476004044	Methyltransferase domain; Region: Methyltransf_31; pfam13847
548476004045	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548476004046	S-adenosylmethionine binding site [chemical binding]; other site
548476004047	RDD family; Region: RDD; pfam06271
548476004048	5'-3' exonuclease; Region: 53EXOc; smart00475
548476004049	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
548476004050	active site
548476004051	metal binding site 1 [ion binding]; metal-binding site
548476004052	putative 5' ssDNA interaction site; other site
548476004053	metal binding site 3; metal-binding site
548476004054	metal binding site 2 [ion binding]; metal-binding site
548476004055	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
548476004056	putative DNA binding site [nucleotide binding]; other site
548476004057	putative metal binding site [ion binding]; other site
548476004058	DNA polymerase I; Provisional; Region: PRK05755
548476004059	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
548476004060	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
548476004061	active site
548476004062	DNA binding site [nucleotide binding]
548476004063	catalytic site [active]
548476004064	Domain of unknown function (DUF368); Region: DUF368; pfam04018
548476004065	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
548476004066	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
548476004067	substrate binding pocket [chemical binding]; other site
548476004068	membrane-bound complex binding site; other site
548476004069	hinge residues; other site
548476004070	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548476004071	dimer interface [polypeptide binding]; other site
548476004072	conserved gate region; other site
548476004073	putative PBP binding loops; other site
548476004074	ABC-ATPase subunit interface; other site
548476004075	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
548476004076	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
548476004077	Walker A/P-loop; other site
548476004078	ATP binding site [chemical binding]; other site
548476004079	Q-loop/lid; other site
548476004080	ABC transporter signature motif; other site
548476004081	Walker B; other site
548476004082	D-loop; other site
548476004083	H-loop/switch region; other site
548476004084	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
548476004085	elongation factor P; Validated; Region: PRK00529
548476004086	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
548476004087	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
548476004088	RNA binding site [nucleotide binding]; other site
548476004089	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
548476004090	RNA binding site [nucleotide binding]; other site
548476004091	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
548476004092	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
548476004093	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
548476004094	active site
548476004095	Dehydroquinase class II; Region: DHquinase_II; pfam01220
548476004096	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
548476004097	trimer interface [polypeptide binding]; other site
548476004098	active site
548476004099	dimer interface [polypeptide binding]; other site
548476004100	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
548476004101	dimer interface [polypeptide binding]; other site
548476004102	active site
548476004103	metal binding site [ion binding]; metal-binding site
548476004104	shikimate kinase; Reviewed; Region: aroK; PRK00131
548476004105	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
548476004106	ADP binding site [chemical binding]; other site
548476004107	magnesium binding site [ion binding]; other site
548476004108	putative shikimate binding site; other site
548476004109	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
548476004110	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
548476004111	Tetramer interface [polypeptide binding]; other site
548476004112	active site
548476004113	FMN-binding site [chemical binding]; other site
548476004114	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
548476004115	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
548476004116	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
548476004117	shikimate binding site; other site
548476004118	NAD(P) binding site [chemical binding]; other site
548476004119	YceG-like family; Region: YceG; pfam02618
548476004120	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
548476004121	dimerization interface [polypeptide binding]; other site
548476004122	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
548476004123	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
548476004124	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
548476004125	motif 1; other site
548476004126	active site
548476004127	motif 2; other site
548476004128	motif 3; other site
548476004129	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
548476004130	DHHA1 domain; Region: DHHA1; pfam02272
548476004131	recombination factor protein RarA; Reviewed; Region: PRK13342
548476004132	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548476004133	Walker A motif; other site
548476004134	ATP binding site [chemical binding]; other site
548476004135	Walker B motif; other site
548476004136	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
548476004137	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
548476004138	active site
548476004139	ATP binding site [chemical binding]; other site
548476004140	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
548476004141	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
548476004142	dimer interface [polypeptide binding]; other site
548476004143	anticodon binding site; other site
548476004144	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
548476004145	homodimer interface [polypeptide binding]; other site
548476004146	motif 1; other site
548476004147	active site
548476004148	motif 2; other site
548476004149	GAD domain; Region: GAD; pfam02938
548476004150	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
548476004151	active site
548476004152	motif 3; other site
548476004153	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
548476004154	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
548476004155	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
548476004156	FOG: CBS domain [General function prediction only]; Region: COG0517
548476004157	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
548476004158	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
548476004159	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
548476004160	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
548476004161	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
548476004162	LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037
548476004163	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
548476004164	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
548476004165	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
548476004166	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
548476004167	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
548476004168	dimer interface [polypeptide binding]; other site
548476004169	motif 1; other site
548476004170	active site
548476004171	motif 2; other site
548476004172	motif 3; other site
548476004173	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
548476004174	anticodon binding site; other site
548476004175	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
548476004176	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
548476004177	dimer interface [polypeptide binding]; other site
548476004178	catalytic triad [active]
548476004179	peroxidatic and resolving cysteines [active]
548476004180	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
548476004181	active site
548476004182	Predicted membrane protein [Function unknown]; Region: COG2323
548476004183	NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530
548476004184	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
548476004185	active site
548476004186	metal binding site [ion binding]; metal-binding site
548476004187	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
548476004188	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
548476004189	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
548476004190	Zn2+ binding site [ion binding]; other site
548476004191	Mg2+ binding site [ion binding]; other site
548476004192	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
548476004193	synthetase active site [active]
548476004194	NTP binding site [chemical binding]; other site
548476004195	metal binding site [ion binding]; metal-binding site
548476004196	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
548476004197	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
548476004198	Protein of unknown function (DUF552); Region: DUF552; cl00775
548476004199	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
548476004200	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
548476004201	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
548476004202	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
548476004203	Protein export membrane protein; Region: SecD_SecF; pfam02355
548476004204	Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342
548476004205	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
548476004206	Preprotein translocase subunit; Region: YajC; pfam02699
548476004207	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
548476004208	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548476004209	Walker A motif; other site
548476004210	ATP binding site [chemical binding]; other site
548476004211	Walker B motif; other site
548476004212	arginine finger; other site
548476004213	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
548476004214	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
548476004215	RuvA N terminal domain; Region: RuvA_N; pfam01330
548476004216	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
548476004217	active site
548476004218	putative DNA-binding cleft [nucleotide binding]; other site
548476004219	dimer interface [polypeptide binding]; other site
548476004220	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
548476004221	FMN binding site [chemical binding]; other site
548476004222	dimer interface [polypeptide binding]; other site
548476004223	hypothetical protein; Validated; Region: PRK00110
548476004224	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
548476004225	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
548476004226	active site
548476004227	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
548476004228	catalytic triad [active]
548476004229	dimer interface [polypeptide binding]; other site
548476004230	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
548476004231	putative transposase OrfB; Reviewed; Region: PHA02517
548476004232	HTH-like domain; Region: HTH_21; pfam13276
548476004233	Integrase core domain; Region: rve; pfam00665
548476004234	Integrase core domain; Region: rve_3; pfam13683
548476004235	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548476004236	Transposase; Region: HTH_Tnp_1; cl17663
548476004237	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
548476004238	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
548476004239	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
548476004240	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
548476004241	putative acyl-acceptor binding pocket; other site
548476004242	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
548476004243	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
548476004244	nucleotide binding site/active site [active]
548476004245	HIT family signature motif; other site
548476004246	catalytic residue [active]
548476004247	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
548476004248	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
548476004249	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
548476004250	active site
548476004251	dimer interface [polypeptide binding]; other site
548476004252	motif 1; other site
548476004253	motif 2; other site
548476004254	motif 3; other site
548476004255	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
548476004256	anticodon binding site; other site
548476004257	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
548476004258	Protein of unknown function (DUF461); Region: DUF461; pfam04314
548476004259	Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372
548476004260	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
548476004261	metal ion-dependent adhesion site (MIDAS); other site
548476004262	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320
548476004263	gating phenylalanine in ion channel; other site
548476004264	RibD C-terminal domain; Region: RibD_C; cl17279
548476004265	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
548476004266	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
548476004267	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
548476004268	SelR domain; Region: SelR; pfam01641
548476004269	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
548476004270	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
548476004271	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
548476004272	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
548476004273	catalytic site [active]
548476004274	putative active site [active]
548476004275	putative substrate binding site [chemical binding]; other site
548476004276	HRDC domain; Region: HRDC; pfam00570
548476004277	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
548476004278	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
548476004279	TPP-binding site; other site
548476004280	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
548476004281	PYR/PP interface [polypeptide binding]; other site
548476004282	dimer interface [polypeptide binding]; other site
548476004283	TPP binding site [chemical binding]; other site
548476004284	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
548476004285	TRAM domain; Region: TRAM; pfam01938
548476004286	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
548476004287	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
548476004288	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
548476004289	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
548476004290	trimer interface [polypeptide binding]; other site
548476004291	active site
548476004292	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
548476004293	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
548476004294	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
548476004295	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
548476004296	nucleotide binding site [chemical binding]; other site
548476004297	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
548476004298	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
548476004299	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
548476004300	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
548476004301	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
548476004302	DNA binding residues [nucleotide binding]
548476004303	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
548476004304	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
548476004305	dimerization domain swap beta strand [polypeptide binding]; other site
548476004306	regulatory protein interface [polypeptide binding]; other site
548476004307	active site
548476004308	regulatory phosphorylation site [posttranslational modification]; other site
548476004309	DAK2 domain; Region: Dak2; cl03685
548476004310	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
548476004311	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
548476004312	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
548476004313	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
548476004314	ATP binding site [chemical binding]; other site
548476004315	putative Mg++ binding site [ion binding]; other site
548476004316	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
548476004317	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
548476004318	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
548476004319	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548476004320	S-adenosylmethionine binding site [chemical binding]; other site
548476004321	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
548476004322	putative active site [active]
548476004323	dimerization interface [polypeptide binding]; other site
548476004324	putative tRNAtyr binding site [nucleotide binding]; other site
548476004325	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
548476004326	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
548476004327	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
548476004328	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
548476004329	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
548476004330	DNA binding residues [nucleotide binding]
548476004331	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
548476004332	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
548476004333	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
548476004334	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
548476004335	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
548476004336	NAD binding site [chemical binding]; other site
548476004337	homodimer interface [polypeptide binding]; other site
548476004338	active site
548476004339	substrate binding site [chemical binding]; other site
548476004340	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
548476004341	PAC2 family; Region: PAC2; pfam09754
548476004342	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
548476004343	ATP binding site [chemical binding]; other site
548476004344	putative Mg++ binding site [ion binding]; other site
548476004345	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
548476004346	nucleotide binding region [chemical binding]; other site
548476004347	ATP-binding site [chemical binding]; other site
548476004348	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
548476004349	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
548476004350	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
548476004351	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
548476004352	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
548476004353	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
548476004354	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
548476004355	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
548476004356	dimer interface [polypeptide binding]; other site
548476004357	decamer (pentamer of dimers) interface [polypeptide binding]; other site
548476004358	catalytic triad [active]
548476004359	peroxidatic and resolving cysteines [active]
548476004360	Transcriptional regulator [Transcription]; Region: LysR; COG0583
548476004361	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
548476004362	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
548476004363	dimerization interface [polypeptide binding]; other site
548476004364	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
548476004365	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
548476004366	ATP binding site [chemical binding]; other site
548476004367	putative Mg++ binding site [ion binding]; other site
548476004368	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
548476004369	nucleotide binding region [chemical binding]; other site
548476004370	ATP-binding site [chemical binding]; other site
548476004371	Helicase associated domain (HA2); Region: HA2; pfam04408
548476004372	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
548476004373	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
548476004374	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
548476004375	ATP cone domain; Region: ATP-cone; pfam03477
548476004376	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
548476004377	dimerization interface [polypeptide binding]; other site
548476004378	putative DNA binding site [nucleotide binding]; other site
548476004379	LexA repressor; Validated; Region: PRK00215
548476004380	putative Zn2+ binding site [ion binding]; other site
548476004381	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
548476004382	Catalytic site [active]
548476004383	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
548476004384	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
548476004385	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
548476004386	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
548476004387	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
548476004388	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
548476004389	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
548476004390	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
548476004391	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
548476004392	putative substrate binding site [chemical binding]; other site
548476004393	putative ATP binding site [chemical binding]; other site
548476004394	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
548476004395	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
548476004396	active site
548476004397	phosphorylation site [posttranslational modification]
548476004398	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
548476004399	active site
548476004400	P-loop; other site
548476004401	phosphorylation site [posttranslational modification]
548476004402	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
548476004403	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
548476004404	dimerization domain swap beta strand [polypeptide binding]; other site
548476004405	regulatory protein interface [polypeptide binding]; other site
548476004406	active site
548476004407	regulatory phosphorylation site [posttranslational modification]; other site
548476004408	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
548476004409	GTPases [General function prediction only]; Region: HflX; COG2262
548476004410	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
548476004411	HflX GTPase family; Region: HflX; cd01878
548476004412	G1 box; other site
548476004413	GTP/Mg2+ binding site [chemical binding]; other site
548476004414	Switch I region; other site
548476004415	G2 box; other site
548476004416	G3 box; other site
548476004417	Switch II region; other site
548476004418	G4 box; other site
548476004419	G5 box; other site
548476004420	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
548476004421	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
548476004422	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
548476004423	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
548476004424	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019
548476004425	active site
548476004426	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
548476004427	catalytic site [active]
548476004428	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
548476004429	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
548476004430	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
548476004431	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
548476004432	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
548476004433	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
548476004434	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
548476004435	FMN binding site [chemical binding]; other site
548476004436	active site
548476004437	substrate binding site [chemical binding]; other site
548476004438	catalytic residue [active]
548476004439	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
548476004440	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
548476004441	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
548476004442	FeS/SAM binding site; other site
548476004443	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
548476004444	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
548476004445	Walker A/P-loop; other site
548476004446	ATP binding site [chemical binding]; other site
548476004447	Q-loop/lid; other site
548476004448	ABC transporter signature motif; other site
548476004449	Walker B; other site
548476004450	D-loop; other site
548476004451	H-loop/switch region; other site
548476004452	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
548476004453	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
548476004454	substrate binding pocket [chemical binding]; other site
548476004455	membrane-bound complex binding site; other site
548476004456	hinge residues; other site
548476004457	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548476004458	dimer interface [polypeptide binding]; other site
548476004459	conserved gate region; other site
548476004460	putative PBP binding loops; other site
548476004461	ABC-ATPase subunit interface; other site
548476004462	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548476004463	dimer interface [polypeptide binding]; other site
548476004464	conserved gate region; other site
548476004465	putative PBP binding loops; other site
548476004466	ABC-ATPase subunit interface; other site
548476004467	recombination regulator RecX; Reviewed; Region: recX; PRK00117
548476004468	recombinase A; Provisional; Region: recA; PRK09354
548476004469	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
548476004470	hexamer interface [polypeptide binding]; other site
548476004471	Walker A motif; other site
548476004472	ATP binding site [chemical binding]; other site
548476004473	Walker B motif; other site
548476004474	Transposase [DNA replication, recombination, and repair]; Region: COG5421
548476004475	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
548476004476	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
548476004477	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
548476004478	Walker A/P-loop; other site
548476004479	ATP binding site [chemical binding]; other site
548476004480	Q-loop/lid; other site
548476004481	ABC transporter signature motif; other site
548476004482	Walker B; other site
548476004483	D-loop; other site
548476004484	H-loop/switch region; other site
548476004485	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
548476004486	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
548476004487	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
548476004488	non-specific DNA binding site [nucleotide binding]; other site
548476004489	salt bridge; other site
548476004490	sequence-specific DNA binding site [nucleotide binding]; other site
548476004491	Competence-damaged protein; Region: CinA; pfam02464
548476004492	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
548476004493	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350
548476004494	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
548476004495	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
548476004496	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
548476004497	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
548476004498	TIGR03085 family protein; Region: TIGR03085
548476004499	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
548476004500	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
548476004501	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
548476004502	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
548476004503	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
548476004504	dimer interface [polypeptide binding]; other site
548476004505	active site
548476004506	catalytic residue [active]
548476004507	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
548476004508	dihydrodipicolinate reductase; Provisional; Region: PRK00048
548476004509	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
548476004510	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
548476004511	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
548476004512	active site
548476004513	AMIN domain; Region: AMIN; pfam11741
548476004514	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
548476004515	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
548476004516	oligomer interface [polypeptide binding]; other site
548476004517	RNA binding site [nucleotide binding]; other site
548476004518	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
548476004519	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
548476004520	RNase E interface [polypeptide binding]; other site
548476004521	trimer interface [polypeptide binding]; other site
548476004522	active site
548476004523	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
548476004524	putative nucleic acid binding region [nucleotide binding]; other site
548476004525	G-X-X-G motif; other site
548476004526	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
548476004527	RNA binding site [nucleotide binding]; other site
548476004528	domain interface; other site
548476004529	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
548476004530	16S/18S rRNA binding site [nucleotide binding]; other site
548476004531	S13e-L30e interaction site [polypeptide binding]; other site
548476004532	25S rRNA binding site [nucleotide binding]; other site
548476004533	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
548476004534	active site
548476004535	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
548476004536	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
548476004537	active site
548476004538	Riboflavin kinase; Region: Flavokinase; smart00904
548476004539	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
548476004540	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
548476004541	RNA binding site [nucleotide binding]; other site
548476004542	active site
548476004543	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
548476004544	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
548476004545	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
548476004546	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
548476004547	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
548476004548	active site
548476004549	metal binding site [ion binding]; metal-binding site
548476004550	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
548476004551	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
548476004552	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
548476004553	DHH family; Region: DHH; pfam01368
548476004554	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
548476004555	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
548476004556	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
548476004557	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
548476004558	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
548476004559	G1 box; other site
548476004560	putative GEF interaction site [polypeptide binding]; other site
548476004561	GTP/Mg2+ binding site [chemical binding]; other site
548476004562	Switch I region; other site
548476004563	G2 box; other site
548476004564	G3 box; other site
548476004565	Switch II region; other site
548476004566	G4 box; other site
548476004567	G5 box; other site
548476004568	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
548476004569	Translation-initiation factor 2; Region: IF-2; pfam11987
548476004570	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
548476004571	Protein of unknown function (DUF448); Region: DUF448; pfam04296
548476004572	putative RNA binding cleft [nucleotide binding]; other site
548476004573	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
548476004574	NusA N-terminal domain; Region: NusA_N; pfam08529
548476004575	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
548476004576	RNA binding site [nucleotide binding]; other site
548476004577	homodimer interface [polypeptide binding]; other site
548476004578	NusA-like KH domain; Region: KH_5; pfam13184
548476004579	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
548476004580	G-X-X-G motif; other site
548476004581	ribosome maturation protein RimP; Reviewed; Region: PRK00092
548476004582	Sm and related proteins; Region: Sm_like; cl00259
548476004583	Predicted membrane protein [Function unknown]; Region: COG4270
548476004584	prolyl-tRNA synthetase; Provisional; Region: PRK09194
548476004585	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
548476004586	dimer interface [polypeptide binding]; other site
548476004587	motif 1; other site
548476004588	active site
548476004589	motif 2; other site
548476004590	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
548476004591	putative deacylase active site [active]
548476004592	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
548476004593	active site
548476004594	motif 3; other site
548476004595	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
548476004596	anticodon binding site; other site
548476004597	hypothetical protein; Validated; Region: PRK02101
548476004598	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
548476004599	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
548476004600	nucleotide binding site/active site [active]
548476004601	HIT family signature motif; other site
548476004602	catalytic residue [active]
548476004603	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
548476004604	hypothetical protein; Validated; Region: PRK00029
548476004605	Uncharacterized conserved protein [Function unknown]; Region: COG0397
548476004606	malate:quinone oxidoreductase; Validated; Region: PRK05257
548476004607	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
548476004608	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
548476004609	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
548476004610	mycothione reductase; Reviewed; Region: PRK07846
548476004611	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
548476004612	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
548476004613	methionine aminopeptidase; Provisional; Region: PRK12318
548476004614	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
548476004615	active site
548476004616	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
548476004617	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
548476004618	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
548476004619	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
548476004620	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
548476004621	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
548476004622	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
548476004623	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
548476004624	active site
548476004625	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
548476004626	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
548476004627	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
548476004628	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
548476004629	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
548476004630	Protein of unknown function (DUF2631); Region: DUF2631; pfam10939
548476004631	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
548476004632	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
548476004633	Walker A/P-loop; other site
548476004634	ATP binding site [chemical binding]; other site
548476004635	Q-loop/lid; other site
548476004636	ABC transporter signature motif; other site
548476004637	Walker B; other site
548476004638	D-loop; other site
548476004639	H-loop/switch region; other site
548476004640	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
548476004641	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
548476004642	FeS/SAM binding site; other site
548476004643	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
548476004644	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
548476004645	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
548476004646	ribosome recycling factor; Reviewed; Region: frr; PRK00083
548476004647	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
548476004648	hinge region; other site
548476004649	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
548476004650	putative nucleotide binding site [chemical binding]; other site
548476004651	uridine monophosphate binding site [chemical binding]; other site
548476004652	homohexameric interface [polypeptide binding]; other site
548476004653	elongation factor Ts; Provisional; Region: tsf; PRK09377
548476004654	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
548476004655	Elongation factor TS; Region: EF_TS; pfam00889
548476004656	Elongation factor TS; Region: EF_TS; pfam00889
548476004657	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
548476004658	rRNA interaction site [nucleotide binding]; other site
548476004659	S8 interaction site; other site
548476004660	putative laminin-1 binding site; other site
548476004661	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
548476004662	Peptidase family M23; Region: Peptidase_M23; pfam01551
548476004663	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
548476004664	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
548476004665	active site
548476004666	DNA binding site [nucleotide binding]
548476004667	Int/Topo IB signature motif; other site
548476004668	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
548476004669	DNA protecting protein DprA; Region: dprA; TIGR00732
548476004670	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
548476004671	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
548476004672	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548476004673	Walker A motif; other site
548476004674	ATP binding site [chemical binding]; other site
548476004675	Walker B motif; other site
548476004676	arginine finger; other site
548476004677	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
548476004678	hypothetical protein; Reviewed; Region: PRK12497
548476004679	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
548476004680	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
548476004681	RNA/DNA hybrid binding site [nucleotide binding]; other site
548476004682	active site
548476004683	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
548476004684	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
548476004685	Catalytic site [active]
548476004686	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
548476004687	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
548476004688	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
548476004689	Catalytic site [active]
548476004690	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
548476004691	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
548476004692	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
548476004693	ThiC-associated domain; Region: ThiC-associated; pfam13667
548476004694	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
548476004695	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
548476004696	active site
548476004697	pyrophosphate binding site [ion binding]; other site
548476004698	thiamine phosphate binding site [chemical binding]; other site
548476004699	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
548476004700	hydroxyglutarate oxidase; Provisional; Region: PRK11728
548476004701	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
548476004702	thiS-thiF/thiG interaction site; other site
548476004703	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
548476004704	ThiS interaction site; other site
548476004705	putative active site [active]
548476004706	tetramer interface [polypeptide binding]; other site
548476004707	thiamine biosynthesis protein ThiF; Validated; Region: PRK05600
548476004708	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
548476004709	ATP binding site [chemical binding]; other site
548476004710	substrate interface [chemical binding]; other site
548476004711	Predicted membrane protein [Function unknown]; Region: COG1511
548476004712	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
548476004713	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
548476004714	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
548476004715	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
548476004716	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
548476004717	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
548476004718	active site
548476004719	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
548476004720	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
548476004721	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
548476004722	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
548476004723	RNA binding site [nucleotide binding]; other site
548476004724	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
548476004725	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
548476004726	RimM N-terminal domain; Region: RimM; pfam01782
548476004727	PRC-barrel domain; Region: PRC; pfam05239
548476004728	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
548476004729	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
548476004730	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
548476004731	WHG domain; Region: WHG; pfam13305
548476004732	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
548476004733	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
548476004734	signal recognition particle protein; Provisional; Region: PRK10867
548476004735	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
548476004736	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
548476004737	P loop; other site
548476004738	GTP binding site [chemical binding]; other site
548476004739	Signal peptide binding domain; Region: SRP_SPB; pfam02978
548476004740	PII uridylyl-transferase; Provisional; Region: glnD; PRK00227
548476004741	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
548476004742	metal binding triad; other site
548476004743	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
548476004744	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
548476004745	Zn2+ binding site [ion binding]; other site
548476004746	Mg2+ binding site [ion binding]; other site
548476004747	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
548476004748	Nitrogen regulatory protein P-II; Region: P-II; smart00938
548476004749	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
548476004750	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612
548476004751	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654
548476004752	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
548476004753	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
548476004754	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
548476004755	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650
548476004756	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
548476004757	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
548476004758	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
548476004759	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
548476004760	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
548476004761	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
548476004762	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
548476004763	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
548476004764	Walker A/P-loop; other site
548476004765	ATP binding site [chemical binding]; other site
548476004766	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
548476004767	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
548476004768	ABC transporter signature motif; other site
548476004769	Walker B; other site
548476004770	D-loop; other site
548476004771	H-loop/switch region; other site
548476004772	acylphosphatase; Provisional; Region: PRK14422
548476004773	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
548476004774	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
548476004775	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
548476004776	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
548476004777	DNA binding site [nucleotide binding]
548476004778	catalytic residue [active]
548476004779	H2TH interface [polypeptide binding]; other site
548476004780	putative catalytic residues [active]
548476004781	turnover-facilitating residue; other site
548476004782	intercalation triad [nucleotide binding]; other site
548476004783	8OG recognition residue [nucleotide binding]; other site
548476004784	putative reading head residues; other site
548476004785	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
548476004786	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
548476004787	ribonuclease III; Reviewed; Region: rnc; PRK00102
548476004788	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
548476004789	dimerization interface [polypeptide binding]; other site
548476004790	active site
548476004791	metal binding site [ion binding]; metal-binding site
548476004792	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
548476004793	dsRNA binding site [nucleotide binding]; other site
548476004794	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
548476004795	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
548476004796	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
548476004797	glutamate dehydrogenase; Provisional; Region: PRK09414
548476004798	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
548476004799	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
548476004800	NAD(P) binding site [chemical binding]; other site
548476004801	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
548476004802	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
548476004803	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
548476004804	metal binding site [ion binding]; metal-binding site
548476004805	putative dimer interface [polypeptide binding]; other site
548476004806	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
548476004807	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
548476004808	homodimer interface [polypeptide binding]; other site
548476004809	active site pocket [active]
548476004810	pyruvate kinase; Provisional; Region: PRK06247
548476004811	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
548476004812	domain interfaces; other site
548476004813	active site
548476004814	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
548476004815	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
548476004816	active site
548476004817	ribulose/triose binding site [chemical binding]; other site
548476004818	phosphate binding site [ion binding]; other site
548476004819	substrate (anthranilate) binding pocket [chemical binding]; other site
548476004820	product (indole) binding pocket [chemical binding]; other site
548476004821	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534
548476004822	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
548476004823	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
548476004824	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
548476004825	substrate binding site [chemical binding]; other site
548476004826	glutamase interaction surface [polypeptide binding]; other site
548476004827	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
548476004828	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
548476004829	active site
548476004830	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
548476004831	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
548476004832	catalytic residues [active]
548476004833	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
548476004834	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
548476004835	putative active site [active]
548476004836	oxyanion strand; other site
548476004837	catalytic triad [active]
548476004838	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548476004839	Major Facilitator Superfamily; Region: MFS_1; pfam07690
548476004840	putative substrate translocation pore; other site
548476004841	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
548476004842	putative active site pocket [active]
548476004843	4-fold oligomerization interface [polypeptide binding]; other site
548476004844	metal binding residues [ion binding]; metal-binding site
548476004845	3-fold/trimer interface [polypeptide binding]; other site
548476004846	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
548476004847	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
548476004848	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548476004849	homodimer interface [polypeptide binding]; other site
548476004850	catalytic residue [active]
548476004851	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
548476004852	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
548476004853	NAD binding site [chemical binding]; other site
548476004854	dimerization interface [polypeptide binding]; other site
548476004855	product binding site; other site
548476004856	substrate binding site [chemical binding]; other site
548476004857	zinc binding site [ion binding]; other site
548476004858	catalytic residues [active]
548476004859	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
548476004860	tetracycline repressor protein TetR; Provisional; Region: PRK13756
548476004861	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
548476004862	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
548476004863	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
548476004864	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
548476004865	active site
548476004866	catalytic site [active]
548476004867	DNA polymerase III subunit epsilon; Validated; Region: PRK06195
548476004868	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
548476004869	active site
548476004870	catalytic site [active]
548476004871	substrate binding site [chemical binding]; other site
548476004872	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038
548476004873	Dimer interface [polypeptide binding]; other site
548476004874	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
548476004875	synthetase active site [active]
548476004876	NTP binding site [chemical binding]; other site
548476004877	metal binding site [ion binding]; metal-binding site
548476004878	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
548476004879	RNA binding surface [nucleotide binding]; other site
548476004880	Uncharacterized conserved protein [Function unknown]; Region: COG1739
548476004881	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
548476004882	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
548476004883	threonine dehydratase; Validated; Region: PRK08639
548476004884	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
548476004885	tetramer interface [polypeptide binding]; other site
548476004886	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548476004887	catalytic residue [active]
548476004888	C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585
548476004889	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
548476004890	Transposase [DNA replication, recombination, and repair]; Region: COG5421
548476004891	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
548476004892	substrate binding site [chemical binding]; other site
548476004893	THF binding site; other site
548476004894	zinc-binding site [ion binding]; other site
548476004895	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
548476004896	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
548476004897	active site
548476004898	PHP Thumb interface [polypeptide binding]; other site
548476004899	metal binding site [ion binding]; metal-binding site
548476004900	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
548476004901	generic binding surface II; other site
548476004902	generic binding surface I; other site
548476004903	Predicted permeases [General function prediction only]; Region: RarD; COG2962
548476004904	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
548476004905	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
548476004906	RNA binding surface [nucleotide binding]; other site
548476004907	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
548476004908	active site
548476004909	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
548476004910	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
548476004911	active site
548476004912	homotetramer interface [polypeptide binding]; other site
548476004913	homodimer interface [polypeptide binding]; other site
548476004914	DNA polymerase IV; Provisional; Region: PRK03348
548476004915	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
548476004916	active site
548476004917	DNA binding site [nucleotide binding]
548476004918	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
548476004919	DNA-binding site [nucleotide binding]; DNA binding site
548476004920	Transcriptional regulators [Transcription]; Region: FadR; COG2186
548476004921	FCD domain; Region: FCD; pfam07729
548476004922	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548476004923	putative substrate translocation pore; other site
548476004924	Major Facilitator Superfamily; Region: MFS_1; pfam07690
548476004925	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
548476004926	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
548476004927	HIGH motif; other site
548476004928	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
548476004929	active site
548476004930	KMSKS motif; other site
548476004931	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
548476004932	tRNA binding surface [nucleotide binding]; other site
548476004933	anticodon binding site; other site
548476004934	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
548476004935	active site
548476004936	DivIVA domain; Region: DivI1A_domain; TIGR03544
548476004937	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
548476004938	Predicted integral membrane protein [Function unknown]; Region: COG0762
548476004939	Protein of unknown function (DUF552); Region: DUF552; pfam04472
548476004940	Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325
548476004941	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
548476004942	catalytic residue [active]
548476004943	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
548476004944	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
548476004945	cell division protein FtsZ; Validated; Region: PRK09330
548476004946	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
548476004947	nucleotide binding site [chemical binding]; other site
548476004948	SulA interaction site; other site
548476004949	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
548476004950	Cell division protein FtsQ; Region: FtsQ; pfam03799
548476004951	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
548476004952	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
548476004953	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
548476004954	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
548476004955	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
548476004956	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
548476004957	active site
548476004958	homodimer interface [polypeptide binding]; other site
548476004959	cell division protein FtsW; Region: ftsW; TIGR02614
548476004960	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141
548476004961	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
548476004962	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
548476004963	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
548476004964	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
548476004965	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
548476004966	Mg++ binding site [ion binding]; other site
548476004967	putative catalytic motif [active]
548476004968	putative substrate binding site [chemical binding]; other site
548476004969	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
548476004970	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
548476004971	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
548476004972	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
548476004973	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
548476004974	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
548476004975	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
548476004976	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
548476004977	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
548476004978	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
548476004979	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
548476004980	MraW methylase family; Region: Methyltransf_5; cl17771
548476004981	cell division protein MraZ; Reviewed; Region: PRK00326
548476004982	MraZ protein; Region: MraZ; pfam02381
548476004983	MraZ protein; Region: MraZ; pfam02381
548476004984	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
548476004985	FtsX-like permease family; Region: FtsX; pfam02687
548476004986	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
548476004987	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
548476004988	Walker A/P-loop; other site
548476004989	ATP binding site [chemical binding]; other site
548476004990	Q-loop/lid; other site
548476004991	ABC transporter signature motif; other site
548476004992	Walker B; other site
548476004993	D-loop; other site
548476004994	H-loop/switch region; other site
548476004995	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
548476004996	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
548476004997	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
548476004998	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
548476004999	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
548476005000	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
548476005001	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
548476005002	substrate binding pocket [chemical binding]; other site
548476005003	chain length determination region; other site
548476005004	substrate-Mg2+ binding site; other site
548476005005	catalytic residues [active]
548476005006	aspartate-rich region 1; other site
548476005007	active site lid residues [active]
548476005008	aspartate-rich region 2; other site
548476005009	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
548476005010	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
548476005011	Catalytic domain of Protein Kinases; Region: PKc; cd00180
548476005012	active site
548476005013	ATP binding site [chemical binding]; other site
548476005014	substrate binding site [chemical binding]; other site
548476005015	activation loop (A-loop); other site
548476005016	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
548476005017	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
548476005018	Predicted membrane protein [Function unknown]; Region: COG4763
548476005019	Acyltransferase family; Region: Acyl_transf_3; pfam01757
548476005020	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
548476005021	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
548476005022	putative acyl-acceptor binding pocket; other site
548476005023	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
548476005024	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
548476005025	nucleotide binding site [chemical binding]; other site
548476005026	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
548476005027	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
548476005028	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
548476005029	NlpC/P60 family; Region: NLPC_P60; pfam00877
548476005030	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
548476005031	NlpC/P60 family; Region: NLPC_P60; pfam00877
548476005032	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
548476005033	heme bH binding site [chemical binding]; other site
548476005034	intrachain domain interface; other site
548476005035	heme bL binding site [chemical binding]; other site
548476005036	interchain domain interface [polypeptide binding]; other site
548476005037	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
548476005038	Qo binding site; other site
548476005039	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
548476005040	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
548476005041	iron-sulfur cluster [ion binding]; other site
548476005042	[2Fe-2S] cluster binding site [ion binding]; other site
548476005043	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
548476005044	Cytochrome c; Region: Cytochrom_C; pfam00034
548476005045	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
548476005046	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
548476005047	Subunit I/III interface [polypeptide binding]; other site
548476005048	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
548476005049	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
548476005050	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
548476005051	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
548476005052	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
548476005053	active site
548476005054	dimer interface [polypeptide binding]; other site
548476005055	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
548476005056	Ligand Binding Site [chemical binding]; other site
548476005057	Molecular Tunnel; other site
548476005058	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
548476005059	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
548476005060	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435
548476005061	active site pocket [active]
548476005062	Branched-chain amino acid aminotransferase; Region: DUF3665; pfam12427
548476005063	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
548476005064	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
548476005065	homodimer interface [polypeptide binding]; other site
548476005066	substrate-cofactor binding pocket; other site
548476005067	catalytic residue [active]
548476005068	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
548476005069	multifunctional aminopeptidase A; Provisional; Region: PRK00913
548476005070	interface (dimer of trimers) [polypeptide binding]; other site
548476005071	Substrate-binding/catalytic site; other site
548476005072	Zn-binding sites [ion binding]; other site
548476005073	glutaminase; Provisional; Region: PRK00971
548476005074	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
548476005075	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
548476005076	catalytic triad [active]
548476005077	metal binding site [ion binding]; metal-binding site
548476005078	conserved cis-peptide bond; other site
548476005079	2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927
548476005080	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
548476005081	E3 interaction surface; other site
548476005082	lipoyl attachment site [posttranslational modification]; other site
548476005083	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
548476005084	E3 interaction surface; other site
548476005085	lipoyl attachment site [posttranslational modification]; other site
548476005086	e3 binding domain; Region: E3_binding; pfam02817
548476005087	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
548476005088	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548476005089	Major Facilitator Superfamily; Region: MFS_1; pfam07690
548476005090	putative substrate translocation pore; other site
548476005091	glycine dehydrogenase; Provisional; Region: PRK05367
548476005092	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
548476005093	tetramer interface [polypeptide binding]; other site
548476005094	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548476005095	catalytic residue [active]
548476005096	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
548476005097	tetramer interface [polypeptide binding]; other site
548476005098	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548476005099	catalytic residue [active]
548476005100	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
548476005101	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
548476005102	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
548476005103	lipoyl attachment site [posttranslational modification]; other site
548476005104	lipoate-protein ligase B; Provisional; Region: PRK14345
548476005105	lipoyl synthase; Provisional; Region: PRK05481
548476005106	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
548476005107	FeS/SAM binding site; other site
548476005108	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
548476005109	RDD family; Region: RDD; pfam06271
548476005110	glutamine synthetase, type I; Region: GlnA; TIGR00653
548476005111	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
548476005112	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
548476005113	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
548476005114	heme binding pocket [chemical binding]; other site
548476005115	Htaa; Region: HtaA; pfam04213
548476005116	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
548476005117	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
548476005118	Walker A/P-loop; other site
548476005119	ATP binding site [chemical binding]; other site
548476005120	Q-loop/lid; other site
548476005121	ABC transporter signature motif; other site
548476005122	Walker B; other site
548476005123	D-loop; other site
548476005124	H-loop/switch region; other site
548476005125	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
548476005126	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
548476005127	ABC-ATPase subunit  interface; other site
548476005128	dimer interface [polypeptide binding]; other site
548476005129	putative PBP binding regions; other site
548476005130	ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
548476005131	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
548476005132	intersubunit interface [polypeptide binding]; other site
548476005133	Htaa; Region: HtaA; pfam04213
548476005134	Htaa; Region: HtaA; pfam04213
548476005135	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320
548476005136	gating phenylalanine in ion channel; other site
548476005137	META domain; Region: META; cl01245
548476005138	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
548476005139	nudix motif; other site
548476005140	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
548476005141	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
548476005142	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
548476005143	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548476005144	catalytic residue [active]
548476005145	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548476005146	Major Facilitator Superfamily; Region: MFS_1; pfam07690
548476005147	putative substrate translocation pore; other site
548476005148	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
548476005149	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
548476005150	metal binding triad; other site
548476005151	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
548476005152	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
548476005153	metal binding triad; other site
548476005154	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
548476005155	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
548476005156	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
548476005157	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
548476005158	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
548476005159	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
548476005160	putative active site; other site
548476005161	putative metal binding residues [ion binding]; other site
548476005162	signature motif; other site
548476005163	putative triphosphate binding site [ion binding]; other site
548476005164	CHAD domain; Region: CHAD; pfam05235
548476005165	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
548476005166	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
548476005167	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
548476005168	RNB domain; Region: RNB; pfam00773
548476005169	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
548476005170	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
548476005171	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
548476005172	RNA/DNA hybrid binding site [nucleotide binding]; other site
548476005173	active site
548476005174	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
548476005175	catalytic core [active]
548476005176	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
548476005177	Putative zinc ribbon domain; Region: DUF164; pfam02591
548476005178	Uncharacterized conserved protein [Function unknown]; Region: COG0327
548476005179	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
548476005180	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
548476005181	Low molecular weight phosphatase family; Region: LMWPc; cd00115
548476005182	active site
548476005183	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
548476005184	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
548476005185	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
548476005186	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
548476005187	dimer interface [polypeptide binding]; other site
548476005188	TPP-binding site [chemical binding]; other site
548476005189	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
548476005190	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
548476005191	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
548476005192	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548476005193	active site
548476005194	motif I; other site
548476005195	motif II; other site
548476005196	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548476005197	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
548476005198	Beta-lactamase; Region: Beta-lactamase; pfam00144
548476005199	Excalibur calcium-binding domain; Region: Excalibur; smart00894
548476005200	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
548476005201	Mechanosensitive ion channel; Region: MS_channel; pfam00924
548476005202	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
548476005203	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
548476005204	Predicted membrane protein [Function unknown]; Region: COG2860
548476005205	UPF0126 domain; Region: UPF0126; pfam03458
548476005206	UPF0126 domain; Region: UPF0126; pfam03458
548476005207	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548476005208	AAA domain; Region: AAA_23; pfam13476
548476005209	AAA domain; Region: AAA_21; pfam13304
548476005210	Walker A/P-loop; other site
548476005211	ATP binding site [chemical binding]; other site
548476005212	AAA domain; Region: AAA_21; pfam13304
548476005213	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
548476005214	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
548476005215	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
548476005216	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
548476005217	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
548476005218	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924
548476005219	Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795
548476005220	Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983
548476005221	YrhK-like protein; Region: YrhK; pfam14145
548476005222	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
548476005223	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
548476005224	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
548476005225	ATP binding site [chemical binding]; other site
548476005226	putative Mg++ binding site [ion binding]; other site
548476005227	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
548476005228	nucleotide binding region [chemical binding]; other site
548476005229	ATP-binding site [chemical binding]; other site
548476005230	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
548476005231	Integrase core domain; Region: rve; pfam00665
548476005232	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
548476005233	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
548476005234	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
548476005235	Excalibur calcium-binding domain; Region: Excalibur; smart00894
548476005236	putative transposase OrfB; Reviewed; Region: PHA02517
548476005237	HTH-like domain; Region: HTH_21; pfam13276
548476005238	Integrase core domain; Region: rve; pfam00665
548476005239	Integrase core domain; Region: rve_3; pfam13683
548476005240	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548476005241	Transposase; Region: HTH_Tnp_1; cl17663
548476005242	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
548476005243	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
548476005244	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
548476005245	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
548476005246	putative glycosyl transferase; Provisional; Region: PRK10073
548476005247	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
548476005248	active site
548476005249	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
548476005250	PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063
548476005251	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
548476005252	PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063
548476005253	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
548476005254	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
548476005255	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
548476005256	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
548476005257	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
548476005258	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
548476005259	active site
548476005260	homodimer interface [polypeptide binding]; other site
548476005261	DNA primase; Validated; Region: dnaG; PRK05667
548476005262	CHC2 zinc finger; Region: zf-CHC2; pfam01807
548476005263	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
548476005264	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
548476005265	active site
548476005266	metal binding site [ion binding]; metal-binding site
548476005267	interdomain interaction site; other site
548476005268	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
548476005269	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
548476005270	RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607
548476005271	active site
548476005272	barstar interaction site; other site
548476005273	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
548476005274	Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399
548476005275	putative active site [active]
548476005276	putative metal binding site [ion binding]; other site
548476005277	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
548476005278	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
548476005279	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
548476005280	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
548476005281	Zn2+ binding site [ion binding]; other site
548476005282	Mg2+ binding site [ion binding]; other site
548476005283	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
548476005284	Repair protein; Region: Repair_PSII; cl01535
548476005285	glycyl-tRNA synthetase; Provisional; Region: PRK04173
548476005286	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
548476005287	motif 1; other site
548476005288	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
548476005289	active site
548476005290	motif 2; other site
548476005291	motif 3; other site
548476005292	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
548476005293	anticodon binding site; other site
548476005294	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
548476005295	dimerization interface [polypeptide binding]; other site
548476005296	putative DNA binding site [nucleotide binding]; other site
548476005297	putative Zn2+ binding site [ion binding]; other site
548476005298	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
548476005299	metal binding site 2 [ion binding]; metal-binding site
548476005300	putative DNA binding helix; other site
548476005301	metal binding site 1 [ion binding]; metal-binding site
548476005302	dimer interface [polypeptide binding]; other site
548476005303	structural Zn2+ binding site [ion binding]; other site
548476005304	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829
548476005305	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
548476005306	catalytic residue [active]
548476005307	putative FPP diphosphate  binding site; other site
548476005308	putative FPP binding hydrophobic cleft; other site
548476005309	dimer interface [polypeptide binding]; other site
548476005310	putative IPP diphosphate binding site; other site
548476005311	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
548476005312	Recombination protein O N terminal; Region: RecO_N; pfam11967
548476005313	Recombination protein O C terminal; Region: RecO_C; pfam02565
548476005314	GTPase Era; Reviewed; Region: era; PRK00089
548476005315	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
548476005316	G1 box; other site
548476005317	GTP/Mg2+ binding site [chemical binding]; other site
548476005318	Switch I region; other site
548476005319	G2 box; other site
548476005320	Switch II region; other site
548476005321	G3 box; other site
548476005322	G4 box; other site
548476005323	G5 box; other site
548476005324	KH domain; Region: KH_2; pfam07650
548476005325	pyridoxamine kinase; Validated; Region: PRK05756
548476005326	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
548476005327	dimer interface [polypeptide binding]; other site
548476005328	pyridoxal binding site [chemical binding]; other site
548476005329	ATP binding site [chemical binding]; other site
548476005330	metal-binding heat shock protein; Provisional; Region: PRK00016
548476005331	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
548476005332	PhoH-like protein; Region: PhoH; pfam02562
548476005333	RNA methyltransferase, RsmE family; Region: TIGR00046
548476005334	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
548476005335	chaperone protein DnaJ; Provisional; Region: PRK14278
548476005336	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
548476005337	HSP70 interaction site [polypeptide binding]; other site
548476005338	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
548476005339	Zn binding sites [ion binding]; other site
548476005340	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
548476005341	dimer interface [polypeptide binding]; other site
548476005342	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
548476005343	AAA ATPase domain; Region: AAA_16; pfam13191
548476005344	coproporphyrinogen III oxidase; Validated; Region: PRK05628
548476005345	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
548476005346	FeS/SAM binding site; other site
548476005347	HemN C-terminal domain; Region: HemN_C; pfam06969
548476005348	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
548476005349	Domain of unknown function DUF21; Region: DUF21; pfam01595
548476005350	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
548476005351	Transporter associated domain; Region: CorC_HlyC; smart01091
548476005352	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
548476005353	Domain of unknown function DUF21; Region: DUF21; pfam01595
548476005354	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
548476005355	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
548476005356	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
548476005357	acyl-activating enzyme (AAE) consensus motif; other site
548476005358	putative AMP binding site [chemical binding]; other site
548476005359	putative active site [active]
548476005360	putative CoA binding site [chemical binding]; other site
548476005361	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
548476005362	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
548476005363	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
548476005364	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
548476005365	substrate binding pocket [chemical binding]; other site
548476005366	catalytic triad [active]
548476005367	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
548476005368	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
548476005369	active site
548476005370	metal binding site [ion binding]; metal-binding site
548476005371	nudix motif; other site
548476005372	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
548476005373	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
548476005374	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
548476005375	Walker A/P-loop; other site
548476005376	ATP binding site [chemical binding]; other site
548476005377	Q-loop/lid; other site
548476005378	ABC transporter signature motif; other site
548476005379	Walker B; other site
548476005380	D-loop; other site
548476005381	H-loop/switch region; other site
548476005382	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
548476005383	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
548476005384	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548476005385	homodimer interface [polypeptide binding]; other site
548476005386	catalytic residue [active]
548476005387	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
548476005388	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
548476005389	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
548476005390	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
548476005391	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
548476005392	DNA-binding site [nucleotide binding]; DNA binding site
548476005393	UTRA domain; Region: UTRA; pfam07702
548476005394	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
548476005395	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
548476005396	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
548476005397	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548476005398	dimer interface [polypeptide binding]; other site
548476005399	conserved gate region; other site
548476005400	putative PBP binding loops; other site
548476005401	ABC-ATPase subunit interface; other site
548476005402	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
548476005403	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548476005404	ABC-ATPase subunit interface; other site
548476005405	putative PBP binding loops; other site
548476005406	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
548476005407	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
548476005408	Walker A/P-loop; other site
548476005409	ATP binding site [chemical binding]; other site
548476005410	Q-loop/lid; other site
548476005411	ABC transporter signature motif; other site
548476005412	Walker B; other site
548476005413	D-loop; other site
548476005414	H-loop/switch region; other site
548476005415	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
548476005416	Walker A/P-loop; other site
548476005417	ATP binding site [chemical binding]; other site
548476005418	Q-loop/lid; other site
548476005419	ABC transporter signature motif; other site
548476005420	Walker B; other site
548476005421	D-loop; other site
548476005422	H-loop/switch region; other site
548476005423	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
548476005424	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
548476005425	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
548476005426	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548476005427	active site
548476005428	phosphorylation site [posttranslational modification]
548476005429	intermolecular recognition site; other site
548476005430	dimerization interface [polypeptide binding]; other site
548476005431	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
548476005432	DNA binding residues [nucleotide binding]
548476005433	dimerization interface [polypeptide binding]; other site
548476005434	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
548476005435	Histidine kinase; Region: HisKA_3; pfam07730
548476005436	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
548476005437	Protease prsW family; Region: PrsW-protease; pfam13367
548476005438	Protease prsW family; Region: PrsW-protease; pfam13367
548476005439	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
548476005440	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
548476005441	metal binding site [ion binding]; metal-binding site
548476005442	dimer interface [polypeptide binding]; other site
548476005443	Putative esterase; Region: Esterase; pfam00756
548476005444	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
548476005445	active site
548476005446	GTP-binding protein LepA; Provisional; Region: PRK05433
548476005447	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
548476005448	G1 box; other site
548476005449	putative GEF interaction site [polypeptide binding]; other site
548476005450	GTP/Mg2+ binding site [chemical binding]; other site
548476005451	Switch I region; other site
548476005452	G2 box; other site
548476005453	G3 box; other site
548476005454	Switch II region; other site
548476005455	G4 box; other site
548476005456	G5 box; other site
548476005457	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
548476005458	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
548476005459	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
548476005460	PemK-like protein; Region: PemK; pfam02452
548476005461	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
548476005462	DNA adenine methylase (dam); Region: dam; TIGR00571
548476005463	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
548476005464	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
548476005465	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
548476005466	hypothetical protein; Validated; Region: PRK05629
548476005467	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
548476005468	Competence protein; Region: Competence; pfam03772
548476005469	SLBB domain; Region: SLBB; pfam10531
548476005470	comEA protein; Region: comE; TIGR01259
548476005471	EDD domain protein, DegV family; Region: DegV; TIGR00762
548476005472	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
548476005473	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
548476005474	catalytic core [active]
548476005475	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
548476005476	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
548476005477	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
548476005478	active site
548476005479	(T/H)XGH motif; other site
548476005480	Cutinase; Region: Cutinase; pfam01083
548476005481	Cutinase; Region: Cutinase; pfam01083
548476005482	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
548476005483	Divergent AAA domain; Region: AAA_4; pfam04326
548476005484	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
548476005485	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
548476005486	putative DNA binding site [nucleotide binding]; other site
548476005487	putative Zn2+ binding site [ion binding]; other site
548476005488	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
548476005489	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
548476005490	putative catalytic cysteine [active]
548476005491	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
548476005492	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
548476005493	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159
548476005494	putative ligand binding site [chemical binding]; other site
548476005495	putative NAD binding site [chemical binding]; other site
548476005496	catalytic site [active]
548476005497	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159
548476005498	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
548476005499	putative ligand binding site [chemical binding]; other site
548476005500	putative NAD binding site [chemical binding]; other site
548476005501	catalytic site [active]
548476005502	gamma-glutamyl kinase; Provisional; Region: PRK05429
548476005503	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
548476005504	nucleotide binding site [chemical binding]; other site
548476005505	homotetrameric interface [polypeptide binding]; other site
548476005506	putative phosphate binding site [ion binding]; other site
548476005507	putative allosteric binding site; other site
548476005508	PUA domain; Region: PUA; pfam01472
548476005509	GTPase CgtA; Reviewed; Region: obgE; PRK12296
548476005510	GTP1/OBG; Region: GTP1_OBG; pfam01018
548476005511	Obg GTPase; Region: Obg; cd01898
548476005512	G1 box; other site
548476005513	GTP/Mg2+ binding site [chemical binding]; other site
548476005514	Switch I region; other site
548476005515	G2 box; other site
548476005516	G3 box; other site
548476005517	Switch II region; other site
548476005518	G4 box; other site
548476005519	G5 box; other site
548476005520	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
548476005521	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
548476005522	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
548476005523	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
548476005524	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
548476005525	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
548476005526	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
548476005527	homodimer interface [polypeptide binding]; other site
548476005528	oligonucleotide binding site [chemical binding]; other site
548476005529	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
548476005530	arsenical-resistance protein; Region: acr3; TIGR00832
548476005531	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
548476005532	dimerization interface [polypeptide binding]; other site
548476005533	putative DNA binding site [nucleotide binding]; other site
548476005534	putative Zn2+ binding site [ion binding]; other site
548476005535	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
548476005536	active site
548476005537	multimer interface [polypeptide binding]; other site
548476005538	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
548476005539	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
548476005540	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
548476005541	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
548476005542	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
548476005543	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
548476005544	active site
548476005545	HIGH motif; other site
548476005546	nucleotide binding site [chemical binding]; other site
548476005547	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
548476005548	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
548476005549	active site
548476005550	KMSKS motif; other site
548476005551	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
548476005552	tRNA binding surface [nucleotide binding]; other site
548476005553	anticodon binding site; other site
548476005554	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
548476005555	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
548476005556	oligomerization interface [polypeptide binding]; other site
548476005557	active site
548476005558	metal binding site [ion binding]; metal-binding site
548476005559	pantoate--beta-alanine ligase; Region: panC; TIGR00018
548476005560	Pantoate-beta-alanine ligase; Region: PanC; cd00560
548476005561	active site
548476005562	ATP-binding site [chemical binding]; other site
548476005563	pantoate-binding site; other site
548476005564	HXXH motif; other site
548476005565	malate dehydrogenase; Provisional; Region: PRK05442
548476005566	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
548476005567	NAD(P) binding site [chemical binding]; other site
548476005568	dimer interface [polypeptide binding]; other site
548476005569	malate binding site [chemical binding]; other site
548476005570	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
548476005571	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
548476005572	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
548476005573	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
548476005574	active site
548476005575	substrate binding site [chemical binding]; other site
548476005576	metal binding site [ion binding]; metal-binding site
548476005577	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
548476005578	intersubunit interface [polypeptide binding]; other site
548476005579	active site
548476005580	catalytic residue [active]
548476005581	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
548476005582	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
548476005583	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
548476005584	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
548476005585	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
548476005586	active site
548476005587	catalytic motif [active]
548476005588	Zn binding site [ion binding]; other site
548476005589	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
548476005590	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
548476005591	Nucleoside recognition; Region: Gate; pfam07670
548476005592	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
548476005593	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
548476005594	MarR family; Region: MarR_2; pfam12802
548476005595	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
548476005596	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
548476005597	ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994
548476005598	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
548476005599	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548476005600	Walker A motif; other site
548476005601	ATP binding site [chemical binding]; other site
548476005602	Walker B motif; other site
548476005603	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
548476005604	benzoate transport; Region: 2A0115; TIGR00895
548476005605	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548476005606	putative substrate translocation pore; other site
548476005607	short chain dehydrogenase; Provisional; Region: PRK06114
548476005608	classical (c) SDRs; Region: SDR_c; cd05233
548476005609	NAD(P) binding site [chemical binding]; other site
548476005610	active site
548476005611	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
548476005612	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
548476005613	oligomer interface [polypeptide binding]; other site
548476005614	active site residues [active]
548476005615	Clp protease; Region: CLP_protease; pfam00574
548476005616	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
548476005617	oligomer interface [polypeptide binding]; other site
548476005618	active site residues [active]
548476005619	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
548476005620	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
548476005621	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
548476005622	FeoA domain; Region: FeoA; pfam04023
548476005623	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
548476005624	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
548476005625	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
548476005626	Class I ribonucleotide reductase; Region: RNR_I; cd01679
548476005627	active site
548476005628	dimer interface [polypeptide binding]; other site
548476005629	catalytic residues [active]
548476005630	effector binding site; other site
548476005631	R2 peptide binding site; other site
548476005632	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
548476005633	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
548476005634	dimer interface [polypeptide binding]; other site
548476005635	putative radical transfer pathway; other site
548476005636	diiron center [ion binding]; other site
548476005637	tyrosyl radical; other site
548476005638	Predicted flavoprotein [General function prediction only]; Region: COG0431
548476005639	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
548476005640	trigger factor; Provisional; Region: tig; PRK01490
548476005641	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
548476005642	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
548476005643	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
548476005644	Peptidase family M23; Region: Peptidase_M23; pfam01551
548476005645	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
548476005646	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
548476005647	active site
548476005648	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
548476005649	tape measure domain; Region: tape_meas_nterm; TIGR02675
548476005650	NlpC/P60 family; Region: NLPC_P60; cl17555
548476005651	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
548476005652	Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053
548476005653	P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651
548476005654	Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152
548476005655	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
548476005656	phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542
548476005657	Phage terminase large subunit; Region: Terminase_3; cl12054
548476005658	Terminase-like family; Region: Terminase_6; pfam03237
548476005659	Homeodomain-like domain; Region: HTH_23; cl17451
548476005660	ParB-like nuclease domain; Region: ParBc; pfam02195
548476005661	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
548476005662	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09744
548476005663	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
548476005664	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
548476005665	dimer interface [polypeptide binding]; other site
548476005666	putative radical transfer pathway; other site
548476005667	diiron center [ion binding]; other site
548476005668	tyrosyl radical; other site
548476005669	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
548476005670	trimer interface [polypeptide binding]; other site
548476005671	active site
548476005672	Endodeoxyribonuclease RusA; Region: RusA; cl01885
548476005673	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
548476005674	DNA methylase; Region: N6_N4_Mtase; pfam01555
548476005675	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
548476005676	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
548476005677	ssDNA binding site [nucleotide binding]; other site
548476005678	dimer interface [polypeptide binding]; other site
548476005679	tetramer (dimer of dimers) interface [polypeptide binding]; other site
548476005680	Thymidylate synthase complementing protein; Region: Thy1; cl03630
548476005681	Helix-turn-helix domain; Region: HTH_36; pfam13730
548476005682	recombination and repair protein RecT; Reviewed; Region: recT; PRK09846
548476005683	YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588
548476005684	Helix-turn-helix domain; Region: HTH_17; pfam12728
548476005685	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
548476005686	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
548476005687	non-specific DNA binding site [nucleotide binding]; other site
548476005688	salt bridge; other site
548476005689	sequence-specific DNA binding site [nucleotide binding]; other site
548476005690	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
548476005691	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
548476005692	DNA binding site [nucleotide binding]
548476005693	Int/Topo IB signature motif; other site
548476005694	active site
548476005695	catalytic residues [active]
548476005696	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
548476005697	amidase catalytic site [active]
548476005698	Zn binding residues [ion binding]; other site
548476005699	substrate binding site [chemical binding]; other site
548476005700	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
548476005701	active site
548476005702	catalytic site [active]
548476005703	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
548476005704	Protein of unknown function (DUF3584); Region: DUF3584; pfam12128
548476005705	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
548476005706	Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382
548476005707	Uncharacterized archaeal coiled-coil protein [Function unknown]; Region: COG1340
548476005708	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cd07307
548476005709	Phage major tail protein 2; Region: Phage_tail_2; cl11463
548476005710	P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651
548476005711	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
548476005712	Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152
548476005713	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
548476005714	thioester formation/cholesterol transfer; other site
548476005715	Phage terminase large subunit; Region: Terminase_3; cl12054
548476005716	Terminase-like family; Region: Terminase_6; pfam03237
548476005717	Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306
548476005718	protein-splicing catalytic site; other site
548476005719	thioester formation/cholesterol transfer; other site
548476005720	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl16942
548476005721	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
548476005722	ParB-like nuclease domain; Region: ParB; smart00470
548476005723	Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_2; cd08822
548476005724	putative active site [active]
548476005725	putative substrate binding site [chemical binding]; other site
548476005726	putative cosubstrate binding site; other site
548476005727	catalytic site [active]
548476005728	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
548476005729	Walker A/P-loop; other site
548476005730	ATP binding site [chemical binding]; other site
548476005731	Q-loop/lid; other site
548476005732	ABC transporter signature motif; other site
548476005733	Walker B; other site
548476005734	D-loop; other site
548476005735	H-loop/switch region; other site
548476005736	PS-10 peptidase S37; Region: Peptidase_S37; pfam05576
548476005737	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
548476005738	trimer interface [polypeptide binding]; other site
548476005739	active site
548476005740	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
548476005741	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
548476005742	dimer interface [polypeptide binding]; other site
548476005743	ssDNA binding site [nucleotide binding]; other site
548476005744	tetramer (dimer of dimers) interface [polypeptide binding]; other site
548476005745	Helix-turn-helix domain; Region: HTH_36; pfam13730
548476005746	NUMOD4 motif; Region: NUMOD4; pfam07463
548476005747	HNH endonuclease; Region: HNH_3; pfam13392
548476005748	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
548476005749	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
548476005750	active site
548476005751	DNA binding site [nucleotide binding]
548476005752	Int/Topo IB signature motif; other site
548476005753	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
548476005754	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
548476005755	active site
548476005756	catalytic tetrad [active]
548476005757	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
548476005758	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
548476005759	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
548476005760	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
548476005761	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
548476005762	Zn binding site [ion binding]; other site
548476005763	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548476005764	Transposase; Region: HTH_Tnp_1; pfam01527
548476005765	putative transposase OrfB; Reviewed; Region: PHA02517
548476005766	HTH-like domain; Region: HTH_21; pfam13276
548476005767	Integrase core domain; Region: rve; pfam00665
548476005768	Integrase core domain; Region: rve_3; pfam13683
548476005769	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
548476005770	active site
548476005771	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
548476005772	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
548476005773	DNA-binding site [nucleotide binding]; DNA binding site
548476005774	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
548476005775	short chain dehydrogenase; Provisional; Region: PRK08219
548476005776	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
548476005777	NAD(P) binding site [chemical binding]; other site
548476005778	active site
548476005779	CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029
548476005780	alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030
548476005781	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
548476005782	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
548476005783	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
548476005784	Walker A/P-loop; other site
548476005785	ATP binding site [chemical binding]; other site
548476005786	Q-loop/lid; other site
548476005787	ABC transporter signature motif; other site
548476005788	Walker B; other site
548476005789	D-loop; other site
548476005790	H-loop/switch region; other site
548476005791	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
548476005792	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
548476005793	Walker A/P-loop; other site
548476005794	ATP binding site [chemical binding]; other site
548476005795	Q-loop/lid; other site
548476005796	ABC transporter signature motif; other site
548476005797	Walker B; other site
548476005798	D-loop; other site
548476005799	H-loop/switch region; other site
548476005800	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
548476005801	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
548476005802	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548476005803	dimer interface [polypeptide binding]; other site
548476005804	ABC-ATPase subunit interface; other site
548476005805	putative PBP binding loops; other site
548476005806	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
548476005807	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548476005808	dimer interface [polypeptide binding]; other site
548476005809	conserved gate region; other site
548476005810	putative PBP binding loops; other site
548476005811	ABC-ATPase subunit interface; other site
548476005812	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
548476005813	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
548476005814	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
548476005815	cystathionine gamma-synthase; Provisional; Region: PRK07811
548476005816	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
548476005817	homodimer interface [polypeptide binding]; other site
548476005818	substrate-cofactor binding pocket; other site
548476005819	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548476005820	catalytic residue [active]
548476005821	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
548476005822	Mechanosensitive ion channel; Region: MS_channel; pfam00924
548476005823	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
548476005824	apolar tunnel; other site
548476005825	heme binding site [chemical binding]; other site
548476005826	dimerization interface [polypeptide binding]; other site
548476005827	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
548476005828	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
548476005829	hexamer interface [polypeptide binding]; other site
548476005830	ligand binding site [chemical binding]; other site
548476005831	putative active site [active]
548476005832	NAD(P) binding site [chemical binding]; other site
548476005833	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
548476005834	active site
548476005835	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
548476005836	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548476005837	Walker A/P-loop; other site
548476005838	ATP binding site [chemical binding]; other site
548476005839	Q-loop/lid; other site
548476005840	ABC transporter signature motif; other site
548476005841	Walker B; other site
548476005842	D-loop; other site
548476005843	H-loop/switch region; other site
548476005844	ABC transporter; Region: ABC_tran_2; pfam12848
548476005845	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
548476005846	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
548476005847	dimer interface [polypeptide binding]; other site
548476005848	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
548476005849	ssDNA binding site [nucleotide binding]; other site
548476005850	tetramer (dimer of dimers) interface [polypeptide binding]; other site
548476005851	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
548476005852	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
548476005853	Transcriptional regulator [Transcription]; Region: LysR; COG0583
548476005854	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
548476005855	Sulfatase; Region: Sulfatase; cl17466
548476005856	PspC domain; Region: PspC; pfam04024
548476005857	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
548476005858	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
548476005859	NAD(P) binding site [chemical binding]; other site
548476005860	active site
548476005861	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
548476005862	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
548476005863	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
548476005864	catalytic site [active]
548476005865	putative active site [active]
548476005866	putative substrate binding site [chemical binding]; other site
548476005867	dimer interface [polypeptide binding]; other site
548476005868	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
548476005869	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
548476005870	FAD binding pocket [chemical binding]; other site
548476005871	FAD binding motif [chemical binding]; other site
548476005872	phosphate binding motif [ion binding]; other site
548476005873	NAD binding pocket [chemical binding]; other site
548476005874	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
548476005875	active site
548476005876	DNA binding site [nucleotide binding]
548476005877	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
548476005878	CoA binding domain; Region: CoA_binding; smart00881
548476005879	CoA-ligase; Region: Ligase_CoA; pfam00549
548476005880	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
548476005881	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
548476005882	CoA-ligase; Region: Ligase_CoA; pfam00549
548476005883	Bacterial Ig-like domain; Region: Big_5; pfam13205
548476005884	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
548476005885	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
548476005886	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
548476005887	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
548476005888	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
548476005889	DNA binding residues [nucleotide binding]
548476005890	MULE transposase domain; Region: MULE; pfam10551
548476005891	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
548476005892	Helix-turn-helix domain; Region: HTH_28; pfam13518
548476005893	MULE transposase domain; Region: MULE; pfam10551
548476005894	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
548476005895	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
548476005896	Walker A/P-loop; other site
548476005897	ATP binding site [chemical binding]; other site
548476005898	Q-loop/lid; other site
548476005899	ABC transporter signature motif; other site
548476005900	Walker B; other site
548476005901	D-loop; other site
548476005902	H-loop/switch region; other site
548476005903	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
548476005904	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
548476005905	ABC-ATPase subunit  interface; other site
548476005906	dimer interface [polypeptide binding]; other site
548476005907	putative PBP binding regions; other site
548476005908	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
548476005909	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
548476005910	intersubunit interface [polypeptide binding]; other site
548476005911	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
548476005912	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
548476005913	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
548476005914	catalytic triad [active]
548476005915	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
548476005916	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
548476005917	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
548476005918	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
548476005919	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
548476005920	Walker A/P-loop; other site
548476005921	ATP binding site [chemical binding]; other site
548476005922	Q-loop/lid; other site
548476005923	ABC transporter signature motif; other site
548476005924	Walker B; other site
548476005925	D-loop; other site
548476005926	H-loop/switch region; other site
548476005927	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
548476005928	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
548476005929	TM-ABC transporter signature motif; other site
548476005930	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
548476005931	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
548476005932	putative ligand binding site [chemical binding]; other site
548476005933	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
548476005934	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
548476005935	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
548476005936	phosphate binding site [ion binding]; other site
548476005937	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
548476005938	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
548476005939	active site 2 [active]
548476005940	active site 1 [active]
548476005941	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
548476005942	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
548476005943	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
548476005944	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
548476005945	putative NAD(P) binding site [chemical binding]; other site
548476005946	active site
548476005947	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
548476005948	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
548476005949	active site
548476005950	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
548476005951	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
548476005952	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548476005953	dimer interface [polypeptide binding]; other site
548476005954	conserved gate region; other site
548476005955	putative PBP binding loops; other site
548476005956	ABC-ATPase subunit interface; other site
548476005957	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
548476005958	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548476005959	dimer interface [polypeptide binding]; other site
548476005960	conserved gate region; other site
548476005961	putative PBP binding loops; other site
548476005962	ABC-ATPase subunit interface; other site
548476005963	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
548476005964	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
548476005965	Walker A/P-loop; other site
548476005966	ATP binding site [chemical binding]; other site
548476005967	Q-loop/lid; other site
548476005968	ABC transporter signature motif; other site
548476005969	Walker B; other site
548476005970	D-loop; other site
548476005971	H-loop/switch region; other site
548476005972	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
548476005973	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
548476005974	Walker A/P-loop; other site
548476005975	ATP binding site [chemical binding]; other site
548476005976	Q-loop/lid; other site
548476005977	ABC transporter signature motif; other site
548476005978	Walker B; other site
548476005979	D-loop; other site
548476005980	H-loop/switch region; other site
548476005981	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
548476005982	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
548476005983	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
548476005984	HflK protein; Region: hflK; TIGR01933
548476005985	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
548476005986	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
548476005987	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
548476005988	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
548476005989	FeS/SAM binding site; other site
548476005990	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
548476005991	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
548476005992	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
548476005993	xanthine permease; Region: pbuX; TIGR03173
548476005994	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
548476005995	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
548476005996	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
548476005997	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
548476005998	integral membrane protein; Region: integ_memb_HG; TIGR03954
548476005999	Glucitol operon activator protein (GutM); Region: GutM; cl01890
548476006000	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
548476006001	active site
548476006002	dimerization interface [polypeptide binding]; other site
548476006003	ribonuclease PH; Reviewed; Region: rph; PRK00173
548476006004	Ribonuclease PH; Region: RNase_PH_bact; cd11362
548476006005	hexamer interface [polypeptide binding]; other site
548476006006	active site
548476006007	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
548476006008	glutamate racemase; Provisional; Region: PRK00865
548476006009	Rhomboid family; Region: Rhomboid; pfam01694
548476006010	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
548476006011	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
548476006012	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
548476006013	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
548476006014	active site
548476006015	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
548476006016	DEAD/DEAH box helicase; Region: DEAD; pfam00270
548476006017	ATP binding site [chemical binding]; other site
548476006018	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
548476006019	putative Mg++ binding site [ion binding]; other site
548476006020	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
548476006021	Peptidyl-tRNA hydrolase [Translation, ribosomal structure and biogenesis]; Region: pth2; cl17334
548476006022	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
548476006023	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
548476006024	phosphoserine phosphatase SerB; Region: serB; TIGR00338
548476006025	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548476006026	motif II; other site
548476006027	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
548476006028	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
548476006029	D-pathway; other site
548476006030	Putative ubiquinol binding site [chemical binding]; other site
548476006031	Low-spin heme (heme b) binding site [chemical binding]; other site
548476006032	Putative water exit pathway; other site
548476006033	Binuclear center (heme o3/CuB) [ion binding]; other site
548476006034	K-pathway; other site
548476006035	Putative proton exit pathway; other site
548476006036	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
548476006037	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
548476006038	dimer interface [polypeptide binding]; other site
548476006039	putative radical transfer pathway; other site
548476006040	diiron center [ion binding]; other site
548476006041	tyrosyl radical; other site
548476006042	Transcriptional regulators [Transcription]; Region: FadR; COG2186
548476006043	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
548476006044	DNA-binding site [nucleotide binding]; DNA binding site
548476006045	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
548476006046	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
548476006047	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
548476006048	Class I ribonucleotide reductase; Region: RNR_I; cd01679
548476006049	active site
548476006050	dimer interface [polypeptide binding]; other site
548476006051	catalytic residues [active]
548476006052	effector binding site; other site
548476006053	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
548476006054	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
548476006055	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
548476006056	catalytic residues [active]
548476006057	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
548476006058	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
548476006059	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548476006060	putative substrate translocation pore; other site
548476006061	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
548476006062	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
548476006063	homodimer interface [polypeptide binding]; other site
548476006064	NAD binding pocket [chemical binding]; other site
548476006065	ATP binding pocket [chemical binding]; other site
548476006066	Mg binding site [ion binding]; other site
548476006067	active-site loop [active]
548476006068	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
548476006069	active site
548476006070	Fructosamine kinase; Region: Fructosamin_kin; cl17579
548476006071	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
548476006072	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
548476006073	catalytic residues [active]
548476006074	phosphoglucomutase; Validated; Region: PRK07564
548476006075	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
548476006076	active site
548476006077	substrate binding site [chemical binding]; other site
548476006078	metal binding site [ion binding]; metal-binding site
548476006079	camphor resistance protein CrcB; Provisional; Region: ccrB; PRK00134
548476006080	CrcB-like protein; Region: CRCB; pfam02537
548476006081	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
548476006082	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
548476006083	FtsX-like permease family; Region: FtsX; pfam02687
548476006084	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
548476006085	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
548476006086	FtsX-like permease family; Region: FtsX; pfam02687
548476006087	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
548476006088	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
548476006089	Walker A/P-loop; other site
548476006090	ATP binding site [chemical binding]; other site
548476006091	Q-loop/lid; other site
548476006092	ABC transporter signature motif; other site
548476006093	Walker B; other site
548476006094	D-loop; other site
548476006095	H-loop/switch region; other site
548476006096	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
548476006097	active site lid residues [active]
548476006098	substrate binding pocket [chemical binding]; other site
548476006099	catalytic residues [active]
548476006100	substrate-Mg2+ binding site; other site
548476006101	aspartate-rich region 1; other site
548476006102	aspartate-rich region 2; other site
548476006103	phytoene desaturase; Region: crtI_fam; TIGR02734
548476006104	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
548476006105	Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020
548476006106	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
548476006107	MgtE intracellular N domain; Region: MgtE_N; pfam03448
548476006108	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
548476006109	Divalent cation transporter; Region: MgtE; pfam01769
548476006110	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
548476006111	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
548476006112	Integrase core domain; Region: rve; pfam00665
548476006113	Integrase core domain; Region: rve_3; cl15866
548476006114	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548476006115	Transposase; Region: HTH_Tnp_1; cl17663
548476006116	HTH-like domain; Region: HTH_21; pfam13276
548476006117	Integrase core domain; Region: rve; pfam00665
548476006118	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548476006119	Transposase; Region: HTH_Tnp_1; cl17663
548476006120	putative transposase OrfB; Reviewed; Region: PHA02517
548476006121	HTH-like domain; Region: HTH_21; pfam13276
548476006122	Integrase core domain; Region: rve; pfam00665
548476006123	Integrase core domain; Region: rve_3; pfam13683
548476006124	Integrase core domain; Region: rve_3; pfam13683
548476006125	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
548476006126	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
548476006127	Walker A motif; other site
548476006128	ATP binding site [chemical binding]; other site
548476006129	Walker B motif; other site
548476006130	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
548476006131	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
548476006132	hinge; other site
548476006133	active site
548476006134	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
548476006135	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
548476006136	DNA binding residues [nucleotide binding]
548476006137	dimerization interface [polypeptide binding]; other site
548476006138	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
548476006139	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
548476006140	dimer interface [polypeptide binding]; other site
548476006141	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548476006142	catalytic residue [active]
548476006143	serine O-acetyltransferase; Region: cysE; TIGR01172
548476006144	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
548476006145	trimer interface [polypeptide binding]; other site
548476006146	active site
548476006147	substrate binding site [chemical binding]; other site
548476006148	CoA binding site [chemical binding]; other site
548476006149	Predicted acetyltransferase [General function prediction only]; Region: COG2388
548476006150	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
548476006151	putative homodimer interface [polypeptide binding]; other site
548476006152	putative homotetramer interface [polypeptide binding]; other site
548476006153	putative allosteric switch controlling residues; other site
548476006154	putative metal binding site [ion binding]; other site
548476006155	putative homodimer-homodimer interface [polypeptide binding]; other site
548476006156	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
548476006157	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
548476006158	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
548476006159	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
548476006160	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
548476006161	FMN binding site [chemical binding]; other site
548476006162	active site
548476006163	catalytic residues [active]
548476006164	substrate binding site [chemical binding]; other site
548476006165	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
548476006166	PhoU domain; Region: PhoU; pfam01895
548476006167	PhoU domain; Region: PhoU; pfam01895
548476006168	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
548476006169	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
548476006170	Walker A/P-loop; other site
548476006171	ATP binding site [chemical binding]; other site
548476006172	Q-loop/lid; other site
548476006173	ABC transporter signature motif; other site
548476006174	Walker B; other site
548476006175	D-loop; other site
548476006176	H-loop/switch region; other site
548476006177	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
548476006178	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548476006179	dimer interface [polypeptide binding]; other site
548476006180	conserved gate region; other site
548476006181	ABC-ATPase subunit interface; other site
548476006182	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
548476006183	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548476006184	dimer interface [polypeptide binding]; other site
548476006185	conserved gate region; other site
548476006186	putative PBP binding loops; other site
548476006187	ABC-ATPase subunit interface; other site
548476006188	PBP superfamily domain; Region: PBP_like_2; cl17296
548476006189	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
548476006190	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
548476006191	Coenzyme A binding pocket [chemical binding]; other site
548476006192	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
548476006193	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
548476006194	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
548476006195	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
548476006196	heme-binding site [chemical binding]; other site
548476006197	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
548476006198	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
548476006199	homodimer interface [polypeptide binding]; other site
548476006200	substrate-cofactor binding pocket; other site
548476006201	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548476006202	catalytic residue [active]
548476006203	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
548476006204	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
548476006205	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
548476006206	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
548476006207	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
548476006208	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
548476006209	dimerization interface [polypeptide binding]; other site
548476006210	putative ATP binding site [chemical binding]; other site
548476006211	amidophosphoribosyltransferase; Provisional; Region: PRK07847
548476006212	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
548476006213	active site
548476006214	tetramer interface [polypeptide binding]; other site
548476006215	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
548476006216	active site
548476006217	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
548476006218	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
548476006219	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
548476006220	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
548476006221	active site 2 [active]
548476006222	active site 1 [active]
548476006223	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
548476006224	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
548476006225	NAD(P) binding site [chemical binding]; other site
548476006226	active site
548476006227	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
548476006228	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
548476006229	dimer interface [polypeptide binding]; other site
548476006230	active site
548476006231	acyl-coenzyme A oxidase; Region: PLN02636
548476006232	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
548476006233	active site
548476006234	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
548476006235	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
548476006236	Predicted esterase [General function prediction only]; Region: COG0627
548476006237	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
548476006238	putative homotetramer interface [polypeptide binding]; other site
548476006239	putative homodimer interface [polypeptide binding]; other site
548476006240	putative allosteric switch controlling residues; other site
548476006241	putative metal binding site [ion binding]; other site
548476006242	putative homodimer-homodimer interface [polypeptide binding]; other site
548476006243	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
548476006244	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
548476006245	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
548476006246	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
548476006247	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
548476006248	active site residue [active]
548476006249	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
548476006250	Transposase [DNA replication, recombination, and repair]; Region: COG5421
548476006251	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
548476006252	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
548476006253	dimerization interface [polypeptide binding]; other site
548476006254	ATP binding site [chemical binding]; other site
548476006255	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
548476006256	dimerization interface [polypeptide binding]; other site
548476006257	ATP binding site [chemical binding]; other site
548476006258	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
548476006259	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
548476006260	putative active site [active]
548476006261	catalytic triad [active]
548476006262	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
548476006263	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
548476006264	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
548476006265	generic binding surface II; other site
548476006266	generic binding surface I; other site
548476006267	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
548476006268	putative active site [active]
548476006269	putative catalytic site [active]
548476006270	putative Mg binding site IVb [ion binding]; other site
548476006271	putative phosphate binding site [ion binding]; other site
548476006272	putative DNA binding site [nucleotide binding]; other site
548476006273	putative Mg binding site IVa [ion binding]; other site
548476006274	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
548476006275	active site
548476006276	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
548476006277	putative active site [active]
548476006278	putative Zn binding site [ion binding]; other site
548476006279	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
548476006280	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
548476006281	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
548476006282	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
548476006283	ATP binding site [chemical binding]; other site
548476006284	active site
548476006285	substrate binding site [chemical binding]; other site
548476006286	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
548476006287	adenylosuccinate lyase; Region: purB; TIGR00928
548476006288	tetramer interface [polypeptide binding]; other site
548476006289	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
548476006290	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
548476006291	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
548476006292	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
548476006293	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
548476006294	nucleotide binding site/active site [active]
548476006295	HIT family signature motif; other site
548476006296	catalytic residue [active]
548476006297	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
548476006298	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
548476006299	dimerization interface [polypeptide binding]; other site
548476006300	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
548476006301	dimer interface [polypeptide binding]; other site
548476006302	phosphorylation site [posttranslational modification]
548476006303	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548476006304	ATP binding site [chemical binding]; other site
548476006305	Mg2+ binding site [ion binding]; other site
548476006306	G-X-G motif; other site
548476006307	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
548476006308	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548476006309	active site
548476006310	phosphorylation site [posttranslational modification]
548476006311	intermolecular recognition site; other site
548476006312	dimerization interface [polypeptide binding]; other site
548476006313	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
548476006314	DNA binding site [nucleotide binding]
548476006315	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
548476006316	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
548476006317	DNA binding residues [nucleotide binding]
548476006318	dimer interface [polypeptide binding]; other site
548476006319	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
548476006320	pyruvate dehydrogenase; Provisional; Region: PRK06546
548476006321	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
548476006322	PYR/PP interface [polypeptide binding]; other site
548476006323	dimer interface [polypeptide binding]; other site
548476006324	tetramer interface [polypeptide binding]; other site
548476006325	TPP binding site [chemical binding]; other site
548476006326	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
548476006327	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
548476006328	TPP-binding site [chemical binding]; other site
548476006329	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
548476006330	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548476006331	putative substrate translocation pore; other site
548476006332	putative transposase OrfB; Reviewed; Region: PHA02517
548476006333	HTH-like domain; Region: HTH_21; pfam13276
548476006334	Integrase core domain; Region: rve; pfam00665
548476006335	Integrase core domain; Region: rve_3; pfam13683
548476006336	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548476006337	Transposase; Region: HTH_Tnp_1; pfam01527
548476006338	Uncharacterized conserved protein [Function unknown]; Region: COG2966
548476006339	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
548476006340	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
548476006341	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
548476006342	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
548476006343	active site
548476006344	homotetramer interface [polypeptide binding]; other site
548476006345	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
548476006346	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
548476006347	Transcriptional regulators [Transcription]; Region: PurR; COG1609
548476006348	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
548476006349	DNA binding site [nucleotide binding]
548476006350	domain linker motif; other site
548476006351	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
548476006352	putative dimerization interface [polypeptide binding]; other site
548476006353	putative ligand binding site [chemical binding]; other site
548476006354	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
548476006355	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
548476006356	intersubunit interface [polypeptide binding]; other site
548476006357	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
548476006358	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548476006359	Walker A/P-loop; other site
548476006360	ATP binding site [chemical binding]; other site
548476006361	Q-loop/lid; other site
548476006362	ABC transporter signature motif; other site
548476006363	Walker B; other site
548476006364	D-loop; other site
548476006365	H-loop/switch region; other site
548476006366	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
548476006367	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
548476006368	dimer interface [polypeptide binding]; other site
548476006369	putative PBP binding regions; other site
548476006370	ABC-ATPase subunit  interface; other site
548476006371	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
548476006372	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
548476006373	Walker A/P-loop; other site
548476006374	ATP binding site [chemical binding]; other site
548476006375	Q-loop/lid; other site
548476006376	ABC transporter signature motif; other site
548476006377	Walker B; other site
548476006378	D-loop; other site
548476006379	H-loop/switch region; other site
548476006380	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
548476006381	Walker A/P-loop; other site
548476006382	ATP binding site [chemical binding]; other site
548476006383	Q-loop/lid; other site
548476006384	ABC transporter signature motif; other site
548476006385	Walker B; other site
548476006386	D-loop; other site
548476006387	H-loop/switch region; other site
548476006388	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
548476006389	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
548476006390	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
548476006391	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
548476006392	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
548476006393	active site
548476006394	HIGH motif; other site
548476006395	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
548476006396	KMSKS motif; other site
548476006397	tRNA binding surface [nucleotide binding]; other site
548476006398	anticodon binding site; other site
548476006399	This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840
548476006400	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
548476006401	homotrimer interaction site [polypeptide binding]; other site
548476006402	zinc binding site [ion binding]; other site
548476006403	CDP-binding sites; other site
548476006404	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
548476006405	substrate binding site; other site
548476006406	dimer interface; other site
548476006407	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
548476006408	DNA repair protein RadA; Provisional; Region: PRK11823
548476006409	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
548476006410	Walker A motif; other site
548476006411	ATP binding site [chemical binding]; other site
548476006412	Walker B motif; other site
548476006413	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
548476006414	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
548476006415	active site clefts [active]
548476006416	zinc binding site [ion binding]; other site
548476006417	dimer interface [polypeptide binding]; other site
548476006418	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
548476006419	endonuclease III; Region: ENDO3c; smart00478
548476006420	minor groove reading motif; other site
548476006421	helix-hairpin-helix signature motif; other site
548476006422	substrate binding pocket [chemical binding]; other site
548476006423	active site
548476006424	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
548476006425	Uncharacterized conserved protein [Function unknown]; Region: COG2966
548476006426	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
548476006427	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
548476006428	Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
548476006429	Secretory lipase; Region: LIP; pfam03583
548476006430	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
548476006431	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
548476006432	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
548476006433	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
548476006434	Clp amino terminal domain; Region: Clp_N; pfam02861
548476006435	Clp amino terminal domain; Region: Clp_N; pfam02861
548476006436	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548476006437	Walker A motif; other site
548476006438	ATP binding site [chemical binding]; other site
548476006439	Walker B motif; other site
548476006440	arginine finger; other site
548476006441	UvrB/uvrC motif; Region: UVR; pfam02151
548476006442	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548476006443	Walker A motif; other site
548476006444	ATP binding site [chemical binding]; other site
548476006445	Walker B motif; other site
548476006446	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
548476006447	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548476006448	Major Facilitator Superfamily; Region: MFS_1; pfam07690
548476006449	putative substrate translocation pore; other site
548476006450	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
548476006451	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
548476006452	dimer interface [polypeptide binding]; other site
548476006453	putative anticodon binding site; other site
548476006454	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
548476006455	motif 1; other site
548476006456	dimer interface [polypeptide binding]; other site
548476006457	active site
548476006458	motif 2; other site
548476006459	motif 3; other site
548476006460	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
548476006461	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
548476006462	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
548476006463	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
548476006464	pantoate--beta-alanine ligase; Region: panC; TIGR00018
548476006465	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
548476006466	active site
548476006467	nucleotide binding site [chemical binding]; other site
548476006468	HIGH motif; other site
548476006469	KMSKS motif; other site
548476006470	Rossmann-like domain; Region: Rossmann-like; pfam10727
548476006471	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
548476006472	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
548476006473	catalytic center binding site [active]
548476006474	ATP binding site [chemical binding]; other site
548476006475	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
548476006476	homooctamer interface [polypeptide binding]; other site
548476006477	active site
548476006478	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
548476006479	dihydropteroate synthase; Region: DHPS; TIGR01496
548476006480	substrate binding pocket [chemical binding]; other site
548476006481	dimer interface [polypeptide binding]; other site
548476006482	inhibitor binding site; inhibition site
548476006483	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
548476006484	homodecamer interface [polypeptide binding]; other site
548476006485	GTP cyclohydrolase I; Provisional; Region: PLN03044
548476006486	active site
548476006487	putative catalytic site residues [active]
548476006488	zinc binding site [ion binding]; other site
548476006489	GTP-CH-I/GFRP interaction surface; other site
548476006490	FtsH Extracellular; Region: FtsH_ext; pfam06480
548476006491	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
548476006492	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548476006493	Walker A motif; other site
548476006494	ATP binding site [chemical binding]; other site
548476006495	Walker B motif; other site
548476006496	arginine finger; other site
548476006497	Peptidase family M41; Region: Peptidase_M41; pfam01434
548476006498	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
548476006499	active site
548476006500	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
548476006501	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
548476006502	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
548476006503	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
548476006504	dimer interface [polypeptide binding]; other site
548476006505	substrate binding site [chemical binding]; other site
548476006506	metal binding sites [ion binding]; metal-binding site
548476006507	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
548476006508	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
548476006509	putative active site [active]
548476006510	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
548476006511	putative active site [active]
548476006512	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
548476006513	Active site serine [active]
548476006514	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
548476006515	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
548476006516	Walker A/P-loop; other site
548476006517	ATP binding site [chemical binding]; other site
548476006518	Q-loop/lid; other site
548476006519	ABC transporter signature motif; other site
548476006520	Walker B; other site
548476006521	D-loop; other site
548476006522	H-loop/switch region; other site
548476006523	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
548476006524	Histidine kinase; Region: HisKA_3; pfam07730
548476006525	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548476006526	ATP binding site [chemical binding]; other site
548476006527	Mg2+ binding site [ion binding]; other site
548476006528	G-X-G motif; other site
548476006529	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
548476006530	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548476006531	active site
548476006532	phosphorylation site [posttranslational modification]
548476006533	intermolecular recognition site; other site
548476006534	dimerization interface [polypeptide binding]; other site
548476006535	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
548476006536	DNA binding residues [nucleotide binding]
548476006537	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
548476006538	Glutamine amidotransferase class-I; Region: GATase; pfam00117
548476006539	glutamine binding [chemical binding]; other site
548476006540	catalytic triad [active]
548476006541	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
548476006542	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
548476006543	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
548476006544	Aminotransferase class IV; Region: Aminotran_4; pfam01063
548476006545	substrate-cofactor binding pocket; other site
548476006546	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548476006547	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
548476006548	active site residue [active]
548476006549	HicB family; Region: HicB; pfam05534
548476006550	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
548476006551	MarR family; Region: MarR_2; pfam12802
548476006552	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
548476006553	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
548476006554	acyl-activating enzyme (AAE) consensus motif; other site
548476006555	AMP binding site [chemical binding]; other site
548476006556	active site
548476006557	CoA binding site [chemical binding]; other site
548476006558	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
548476006559	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
548476006560	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
548476006561	putative trimer interface [polypeptide binding]; other site
548476006562	putative CoA binding site [chemical binding]; other site
548476006563	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
548476006564	putative trimer interface [polypeptide binding]; other site
548476006565	putative CoA binding site [chemical binding]; other site
548476006566	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
548476006567	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
548476006568	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
548476006569	ring oligomerisation interface [polypeptide binding]; other site
548476006570	ATP/Mg binding site [chemical binding]; other site
548476006571	stacking interactions; other site
548476006572	hinge regions; other site
548476006573	Predicted membrane protein [Function unknown]; Region: COG1297
548476006574	putative oligopeptide transporter, OPT family; Region: TIGR00733
548476006575	hypothetical protein; Provisional; Region: PRK07907
548476006576	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
548476006577	active site
548476006578	metal binding site [ion binding]; metal-binding site
548476006579	dimer interface [polypeptide binding]; other site
548476006580	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644
548476006581	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
548476006582	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
548476006583	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
548476006584	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946
548476006585	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665
548476006586	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
548476006587	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
548476006588	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948
548476006589	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12592
548476006590	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
548476006591	carboxylate-amine ligase; Provisional; Region: PRK13517
548476006592	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
548476006593	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
548476006594	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
548476006595	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
548476006596	active site
548476006597	catalytic residues [active]
548476006598	metal binding site [ion binding]; metal-binding site
548476006599	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
548476006600	Coenzyme A binding pocket [chemical binding]; other site
548476006601	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
548476006602	putative catalytic site [active]
548476006603	putative phosphate binding site [ion binding]; other site
548476006604	active site
548476006605	metal binding site A [ion binding]; metal-binding site
548476006606	DNA binding site [nucleotide binding]
548476006607	putative AP binding site [nucleotide binding]; other site
548476006608	putative metal binding site B [ion binding]; other site
548476006609	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
548476006610	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
548476006611	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
548476006612	putative active site [active]
548476006613	catalytic site [active]
548476006614	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
548476006615	putative active site [active]
548476006616	catalytic site [active]
548476006617	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
548476006618	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548476006619	putative substrate translocation pore; other site
548476006620	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
548476006621	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
548476006622	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
548476006623	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548476006624	Walker A/P-loop; other site
548476006625	ATP binding site [chemical binding]; other site
548476006626	Q-loop/lid; other site
548476006627	ABC transporter signature motif; other site
548476006628	Walker B; other site
548476006629	D-loop; other site
548476006630	H-loop/switch region; other site
548476006631	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
548476006632	nudix motif; other site
548476006633	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
548476006634	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
548476006635	substrate binding pocket [chemical binding]; other site
548476006636	membrane-bound complex binding site; other site
548476006637	hinge residues; other site
548476006638	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
548476006639	Catalytic domain of Protein Kinases; Region: PKc; cd00180
548476006640	active site
548476006641	ATP binding site [chemical binding]; other site
548476006642	substrate binding site [chemical binding]; other site
548476006643	activation loop (A-loop); other site
548476006644	propionate/acetate kinase; Provisional; Region: PRK12379
548476006645	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
548476006646	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
548476006647	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
548476006648	active site turn [active]
548476006649	phosphorylation site [posttranslational modification]
548476006650	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
548476006651	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
548476006652	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
548476006653	HPr interaction site; other site
548476006654	glycerol kinase (GK) interaction site [polypeptide binding]; other site
548476006655	active site
548476006656	phosphorylation site [posttranslational modification]
548476006657	transcriptional antiterminator BglG; Provisional; Region: PRK09772
548476006658	CAT RNA binding domain; Region: CAT_RBD; smart01061
548476006659	PRD domain; Region: PRD; pfam00874
548476006660	PRD domain; Region: PRD; pfam00874
548476006661	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
548476006662	active site
548476006663	catalytic site [active]
548476006664	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
548476006665	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
548476006666	ATP-grasp domain; Region: ATP-grasp; pfam02222
548476006667	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
548476006668	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
548476006669	GDP-binding site [chemical binding]; other site
548476006670	ACT binding site; other site
548476006671	IMP binding site; other site
548476006672	Abi-like protein; Region: Abi_2; cl01988
548476006673	Predicted membrane protein [Function unknown]; Region: COG4129
548476006674	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
548476006675	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
548476006676	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
548476006677	transmembrane helices; other site
548476006678	L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228
548476006679	tartrate dehydratase subunit alpha; Validated; Region: PRK08230
548476006680	Cupin domain; Region: Cupin_2; cl17218
548476006681	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
548476006682	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
548476006683	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
548476006684	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
548476006685	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
548476006686	active site
548476006687	intersubunit interface [polypeptide binding]; other site
548476006688	zinc binding site [ion binding]; other site
548476006689	Na+ binding site [ion binding]; other site
548476006690	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
548476006691	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
548476006692	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
548476006693	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
548476006694	active site
548476006695	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
548476006696	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
548476006697	active site residue [active]
548476006698	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
548476006699	active site residue [active]
548476006700	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
548476006701	Clp amino terminal domain; Region: Clp_N; pfam02861
548476006702	Clp amino terminal domain; Region: Clp_N; pfam02861
548476006703	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548476006704	Walker A motif; other site
548476006705	ATP binding site [chemical binding]; other site
548476006706	Walker B motif; other site
548476006707	arginine finger; other site
548476006708	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548476006709	Walker A motif; other site
548476006710	ATP binding site [chemical binding]; other site
548476006711	Walker B motif; other site
548476006712	arginine finger; other site
548476006713	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
548476006714	WHG domain; Region: WHG; pfam13305
548476006715	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
548476006716	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
548476006717	FAD binding pocket [chemical binding]; other site
548476006718	conserved FAD binding motif [chemical binding]; other site
548476006719	phosphate binding motif [ion binding]; other site
548476006720	beta-alpha-beta structure motif; other site
548476006721	NAD binding pocket [chemical binding]; other site
548476006722	Predicted amidohydrolase [General function prediction only]; Region: COG0388
548476006723	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
548476006724	putative active site [active]
548476006725	catalytic triad [active]
548476006726	putative dimer interface [polypeptide binding]; other site
548476006727	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
548476006728	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
548476006729	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
548476006730	NAD(P) binding site [chemical binding]; other site
548476006731	catalytic residues [active]
548476006732	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
548476006733	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
548476006734	DNA binding residues [nucleotide binding]
548476006735	putative dimer interface [polypeptide binding]; other site
548476006736	chaperone protein DnaJ; Provisional; Region: PRK14279
548476006737	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
548476006738	HSP70 interaction site [polypeptide binding]; other site
548476006739	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
548476006740	Zn binding sites [ion binding]; other site
548476006741	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
548476006742	dimer interface [polypeptide binding]; other site
548476006743	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
548476006744	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
548476006745	dimer interface [polypeptide binding]; other site
548476006746	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
548476006747	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
548476006748	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
548476006749	nucleotide binding site [chemical binding]; other site
548476006750	NEF interaction site [polypeptide binding]; other site
548476006751	SBD interface [polypeptide binding]; other site
548476006752	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
548476006753	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
548476006754	Walker A/P-loop; other site
548476006755	ATP binding site [chemical binding]; other site
548476006756	Q-loop/lid; other site
548476006757	ABC transporter signature motif; other site
548476006758	Walker B; other site
548476006759	D-loop; other site
548476006760	H-loop/switch region; other site
548476006761	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
548476006762	ABC-ATPase subunit  interface; other site
548476006763	dimer interface [polypeptide binding]; other site
548476006764	putative PBP binding regions; other site
548476006765	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
548476006766	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
548476006767	ABC-ATPase subunit  interface; other site
548476006768	dimer interface [polypeptide binding]; other site
548476006769	putative PBP binding regions; other site
548476006770	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
548476006771	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
548476006772	siderophore binding site; other site
548476006773	Proline dehydrogenase; Region: Pro_dh; cl03282
548476006774	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
548476006775	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
548476006776	NAD(P) binding site [chemical binding]; other site
548476006777	catalytic residues [active]
548476006778	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
548476006779	Domain of unknown function DUF20; Region: UPF0118; pfam01594
548476006780	nucleosidase; Provisional; Region: PRK05634
548476006781	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
548476006782	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
548476006783	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
548476006784	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
548476006785	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
548476006786	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
548476006787	CysD dimerization site [polypeptide binding]; other site
548476006788	G1 box; other site
548476006789	putative GEF interaction site [polypeptide binding]; other site
548476006790	GTP/Mg2+ binding site [chemical binding]; other site
548476006791	Switch I region; other site
548476006792	G2 box; other site
548476006793	G3 box; other site
548476006794	Switch II region; other site
548476006795	G4 box; other site
548476006796	G5 box; other site
548476006797	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
548476006798	Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G.  Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786
548476006799	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
548476006800	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
548476006801	Active Sites [active]
548476006802	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
548476006803	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
548476006804	Active Sites [active]
548476006805	ferredoxin-NADP+ reductase; Region: PLN02852
548476006806	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
548476006807	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
548476006808	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548476006809	Walker A/P-loop; other site
548476006810	ATP binding site [chemical binding]; other site
548476006811	Q-loop/lid; other site
548476006812	ABC transporter signature motif; other site
548476006813	Walker B; other site
548476006814	D-loop; other site
548476006815	H-loop/switch region; other site
548476006816	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
548476006817	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
548476006818	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
548476006819	Walker A/P-loop; other site
548476006820	ATP binding site [chemical binding]; other site
548476006821	Q-loop/lid; other site
548476006822	ABC transporter signature motif; other site
548476006823	Walker B; other site
548476006824	D-loop; other site
548476006825	H-loop/switch region; other site
548476006826	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
548476006827	4Fe-4S binding domain; Region: Fer4; cl02805
548476006828	Cysteine-rich domain; Region: CCG; pfam02754
548476006829	Cysteine-rich domain; Region: CCG; pfam02754
548476006830	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
548476006831	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
548476006832	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
548476006833	aminotransferase AlaT; Validated; Region: PRK09265
548476006834	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
548476006835	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548476006836	homodimer interface [polypeptide binding]; other site
548476006837	catalytic residue [active]
548476006838	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
548476006839	active site
548476006840	Predicted multitransmembrane protein [Function unknown]; Region: COG5438
548476006841	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
548476006842	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
548476006843	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
548476006844	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
548476006845	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
548476006846	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548476006847	Walker A/P-loop; other site
548476006848	ATP binding site [chemical binding]; other site
548476006849	Q-loop/lid; other site
548476006850	ABC transporter signature motif; other site
548476006851	Walker B; other site
548476006852	D-loop; other site
548476006853	H-loop/switch region; other site
548476006854	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
548476006855	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
548476006856	VanW like protein; Region: VanW; pfam04294
548476006857	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
548476006858	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
548476006859	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
548476006860	Ligand Binding Site [chemical binding]; other site
548476006861	Protein of unknown function (DUF2613); Region: DUF2613; pfam11021
548476006862	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
548476006863	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
548476006864	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
548476006865	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
548476006866	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
548476006867	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548476006868	S-adenosylmethionine binding site [chemical binding]; other site
548476006869	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
548476006870	active site
548476006871	substrate-binding site [chemical binding]; other site
548476006872	metal-binding site [ion binding]
548476006873	GTP binding site [chemical binding]; other site
548476006874	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548476006875	S-adenosylmethionine binding site [chemical binding]; other site
548476006876	LabA_like proteins; Region: LabA_like; cd06167
548476006877	putative metal binding site [ion binding]; other site
548476006878	MMPL family; Region: MMPL; pfam03176
548476006879	MMPL family; Region: MMPL; pfam03176
548476006880	Predicted integral membrane protein [Function unknown]; Region: COG0392
548476006881	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
548476006882	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
548476006883	active site
548476006884	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
548476006885	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
548476006886	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
548476006887	Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835
548476006888	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
548476006889	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
548476006890	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
548476006891	active site
548476006892	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
548476006893	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
548476006894	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
548476006895	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
548476006896	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
548476006897	acyl-activating enzyme (AAE) consensus motif; other site
548476006898	active site
548476006899	Cutinase; Region: Cutinase; pfam01083
548476006900	Putative esterase; Region: Esterase; pfam00756
548476006901	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
548476006902	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
548476006903	LGFP repeat; Region: LGFP; pfam08310
548476006904	LGFP repeat; Region: LGFP; pfam08310
548476006905	LGFP repeat; Region: LGFP; pfam08310
548476006906	LGFP repeat; Region: LGFP; pfam08310
548476006907	Predicted esterase [General function prediction only]; Region: COG0627
548476006908	S-formylglutathione hydrolase; Region: PLN02442
548476006909	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
548476006910	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
548476006911	active site
548476006912	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
548476006913	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
548476006914	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
548476006915	active site
548476006916	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
548476006917	Transposase; Region: DEDD_Tnp_IS110; pfam01548
548476006918	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
548476006919	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
548476006920	UDP-galactopyranose mutase; Region: GLF; pfam03275
548476006921	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
548476006922	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
548476006923	amidase catalytic site [active]
548476006924	Zn binding residues [ion binding]; other site
548476006925	substrate binding site [chemical binding]; other site
548476006926	LGFP repeat; Region: LGFP; pfam08310
548476006927	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
548476006928	active site
548476006929	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548476006930	Transposase; Region: HTH_Tnp_1; cl17663
548476006931	putative transposase OrfB; Reviewed; Region: PHA02517
548476006932	HTH-like domain; Region: HTH_21; pfam13276
548476006933	Integrase core domain; Region: rve; pfam00665
548476006934	Integrase core domain; Region: rve_3; pfam13683
548476006935	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548476006936	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
548476006937	active site
548476006938	motif I; other site
548476006939	motif II; other site
548476006940	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548476006941	glycerol kinase; Provisional; Region: glpK; PRK00047
548476006942	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
548476006943	N- and C-terminal domain interface [polypeptide binding]; other site
548476006944	active site
548476006945	MgATP binding site [chemical binding]; other site
548476006946	catalytic site [active]
548476006947	metal binding site [ion binding]; metal-binding site
548476006948	putative homotetramer interface [polypeptide binding]; other site
548476006949	glycerol binding site [chemical binding]; other site
548476006950	homodimer interface [polypeptide binding]; other site
548476006951	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
548476006952	amphipathic channel; other site
548476006953	Asn-Pro-Ala signature motifs; other site
548476006954	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
548476006955	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
548476006956	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
548476006957	putative acyl-acceptor binding pocket; other site
548476006958	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
548476006959	seryl-tRNA synthetase; Provisional; Region: PRK05431
548476006960	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
548476006961	dimer interface [polypeptide binding]; other site
548476006962	active site
548476006963	motif 1; other site
548476006964	motif 2; other site
548476006965	motif 3; other site
548476006966	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
548476006967	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
548476006968	DNA-binding site [nucleotide binding]; DNA binding site
548476006969	UTRA domain; Region: UTRA; pfam07702
548476006970	Septum formation; Region: Septum_form; pfam13845
548476006971	Septum formation; Region: Septum_form; pfam13845
548476006972	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
548476006973	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
548476006974	catalytic core [active]
548476006975	prephenate dehydratase; Provisional; Region: PRK11898
548476006976	Prephenate dehydratase; Region: PDT; pfam00800
548476006977	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
548476006978	putative L-Phe binding site [chemical binding]; other site
548476006979	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
548476006980	Amidase; Region: Amidase; cl11426
548476006981	CAAX protease self-immunity; Region: Abi; pfam02517
548476006982	Transcriptional regulator [Transcription]; Region: LytR; COG1316
548476006983	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
548476006984	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
548476006985	putative active site [active]
548476006986	catalytic site [active]
548476006987	putative metal binding site [ion binding]; other site
548476006988	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
548476006989	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
548476006990	tetramer (dimer of dimers) interface [polypeptide binding]; other site
548476006991	NAD binding site [chemical binding]; other site
548476006992	dimer interface [polypeptide binding]; other site
548476006993	substrate binding site [chemical binding]; other site
548476006994	Predicted membrane protein [Function unknown]; Region: COG4425
548476006995	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
548476006996	methionine sulfoxide reductase A; Provisional; Region: PRK00058
548476006997	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
548476006998	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
548476006999	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
548476007000	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
548476007001	Carbon starvation protein CstA; Region: CstA; pfam02554
548476007002	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
548476007003	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
548476007004	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
548476007005	P loop; other site
548476007006	Nucleotide binding site [chemical binding]; other site
548476007007	DTAP/Switch II; other site
548476007008	Switch I; other site
548476007009	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
548476007010	Transcriptional regulator [Transcription]; Region: LysR; COG0583
548476007011	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
548476007012	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
548476007013	dimerization interface [polypeptide binding]; other site
548476007014	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548476007015	putative substrate translocation pore; other site
548476007016	Major Facilitator Superfamily; Region: MFS_1; pfam07690
548476007017	Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
548476007018	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
548476007019	Lsr2; Region: Lsr2; pfam11774
548476007020	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
548476007021	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548476007022	active site
548476007023	phosphorylation site [posttranslational modification]
548476007024	intermolecular recognition site; other site
548476007025	dimerization interface [polypeptide binding]; other site
548476007026	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
548476007027	DNA binding residues [nucleotide binding]
548476007028	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
548476007029	Histidine kinase; Region: HisKA_3; pfam07730
548476007030	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548476007031	ATP binding site [chemical binding]; other site
548476007032	Mg2+ binding site [ion binding]; other site
548476007033	G-X-G motif; other site
548476007034	Domain of unknown function (DUF2020); Region: DUF2020; pfam09449
548476007035	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
548476007036	active site
548476007037	catalytic site [active]
548476007038	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
548476007039	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
548476007040	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
548476007041	Predicted membrane protein [Function unknown]; Region: COG2261
548476007042	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
548476007043	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
548476007044	Ligand Binding Site [chemical binding]; other site
548476007045	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
548476007046	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
548476007047	active site
548476007048	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
548476007049	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548476007050	Walker A/P-loop; other site
548476007051	ATP binding site [chemical binding]; other site
548476007052	Q-loop/lid; other site
548476007053	ABC transporter signature motif; other site
548476007054	Walker B; other site
548476007055	D-loop; other site
548476007056	H-loop/switch region; other site
548476007057	Predicted transcriptional regulators [Transcription]; Region: COG1725
548476007058	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
548476007059	DNA-binding site [nucleotide binding]; DNA binding site
548476007060	LabA_like proteins; Region: LabA_like; cd06167
548476007061	putative metal binding site [ion binding]; other site
548476007062	Uncharacterized conserved protein [Function unknown]; Region: COG1432
548476007063	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
548476007064	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
548476007065	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
548476007066	catalytic residues [active]
548476007067	Heavy-metal-associated domain; Region: HMA; pfam00403
548476007068	metal-binding site [ion binding]
548476007069	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
548476007070	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
548476007071	metal-binding site [ion binding]
548476007072	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
548476007073	benzoate transport; Region: 2A0115; TIGR00895
548476007074	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548476007075	putative substrate translocation pore; other site
548476007076	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548476007077	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
548476007078	replicative DNA helicase; Region: DnaB; TIGR00665
548476007079	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
548476007080	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
548476007081	Walker A motif; other site
548476007082	ATP binding site [chemical binding]; other site
548476007083	Walker B motif; other site
548476007084	DNA binding loops [nucleotide binding]
548476007085	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
548476007086	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
548476007087	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
548476007088	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
548476007089	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
548476007090	dimer interface [polypeptide binding]; other site
548476007091	ssDNA binding site [nucleotide binding]; other site
548476007092	tetramer (dimer of dimers) interface [polypeptide binding]; other site
548476007093	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
548476007094	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
548476007095	Predicted integral membrane protein [Function unknown]; Region: COG5650
548476007096	Transglycosylase; Region: Transgly; pfam00912
548476007097	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
548476007098	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
548476007099	Transcriptional regulators [Transcription]; Region: MarR; COG1846
548476007100	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
548476007101	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
548476007102	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
548476007103	Ligand Binding Site [chemical binding]; other site
548476007104	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
548476007105	Ligand Binding Site [chemical binding]; other site
548476007106	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
548476007107	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
548476007108	active site residue [active]
548476007109	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
548476007110	hypothetical protein; Provisional; Region: PRK13663
548476007111	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
548476007112	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
548476007113	putative substrate binding site [chemical binding]; other site
548476007114	putative ATP binding site [chemical binding]; other site
548476007115	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
548476007116	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
548476007117	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
548476007118	Walker A/P-loop; other site
548476007119	ATP binding site [chemical binding]; other site
548476007120	Q-loop/lid; other site
548476007121	ABC transporter signature motif; other site
548476007122	Walker B; other site
548476007123	D-loop; other site
548476007124	H-loop/switch region; other site
548476007125	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
548476007126	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
548476007127	Histidine kinase; Region: HisKA_3; pfam07730
548476007128	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548476007129	ATP binding site [chemical binding]; other site
548476007130	Mg2+ binding site [ion binding]; other site
548476007131	G-X-G motif; other site
548476007132	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
548476007133	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548476007134	active site
548476007135	phosphorylation site [posttranslational modification]
548476007136	intermolecular recognition site; other site
548476007137	dimerization interface [polypeptide binding]; other site
548476007138	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
548476007139	DNA binding residues [nucleotide binding]
548476007140	dimerization interface [polypeptide binding]; other site
548476007141	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
548476007142	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
548476007143	VanZ like family; Region: VanZ; cl01971
548476007144	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
548476007145	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
548476007146	NADP binding site [chemical binding]; other site
548476007147	dimer interface [polypeptide binding]; other site
548476007148	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
548476007149	Na2 binding site [ion binding]; other site
548476007150	putative substrate binding site 1 [chemical binding]; other site
548476007151	Na binding site 1 [ion binding]; other site
548476007152	putative substrate binding site 2 [chemical binding]; other site
548476007153	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
548476007154	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
548476007155	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548476007156	Transposase; Region: HTH_Tnp_1; pfam01527
548476007157	putative transposase OrfB; Reviewed; Region: PHA02517
548476007158	HTH-like domain; Region: HTH_21; pfam13276
548476007159	Integrase core domain; Region: rve; pfam00665
548476007160	Integrase core domain; Region: rve_3; pfam13683
548476007161	putative transposase OrfB; Reviewed; Region: PHA02517
548476007162	HTH-like domain; Region: HTH_21; pfam13276
548476007163	Integrase core domain; Region: rve; pfam00665
548476007164	Integrase core domain; Region: rve_3; pfam13683
548476007165	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548476007166	Transposase; Region: HTH_Tnp_1; cl17663
548476007167	EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463
548476007168	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
548476007169	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
548476007170	active site
548476007171	HIGH motif; other site
548476007172	nucleotide binding site [chemical binding]; other site
548476007173	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
548476007174	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
548476007175	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
548476007176	active site
548476007177	KMSKS motif; other site
548476007178	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
548476007179	tRNA binding surface [nucleotide binding]; other site
548476007180	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
548476007181	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
548476007182	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
548476007183	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
548476007184	ATP binding site [chemical binding]; other site
548476007185	putative Mg++ binding site [ion binding]; other site
548476007186	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
548476007187	nucleotide binding region [chemical binding]; other site
548476007188	ATP-binding site [chemical binding]; other site
548476007189	Helix-turn-helix domain; Region: HTH_17; cl17695
548476007190	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
548476007191	Mrr N-terminal domain; Region: Mrr_N; pfam14338
548476007192	Restriction endonuclease; Region: Mrr_cat; pfam04471
548476007193	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
548476007194	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
548476007195	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
548476007196	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
548476007197	HsdM N-terminal domain; Region: HsdM_N; pfam12161
548476007198	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548476007199	S-adenosylmethionine binding site [chemical binding]; other site
548476007200	Fic/DOC family; Region: Fic; cl00960
548476007201	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
548476007202	MOSC domain; Region: MOSC; pfam03473
548476007203	Divergent AAA domain; Region: AAA_4; pfam04326
548476007204	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
548476007205	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
548476007206	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
548476007207	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
548476007208	Fic family protein [Function unknown]; Region: COG3177
548476007209	Fic/DOC family; Region: Fic; pfam02661
548476007210	Putative glycolipid-binding; Region: Glycolipid_bind; cl01425
548476007211	hypothetical protein; Provisional; Region: PRK09256
548476007212	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
548476007213	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
548476007214	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
548476007215	non-specific DNA binding site [nucleotide binding]; other site
548476007216	salt bridge; other site
548476007217	sequence-specific DNA binding site [nucleotide binding]; other site
548476007218	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
548476007219	dimerization interface [polypeptide binding]; other site
548476007220	putative DNA binding site [nucleotide binding]; other site
548476007221	putative Zn2+ binding site [ion binding]; other site
548476007222	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
548476007223	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
548476007224	Soluble P-type ATPase [General function prediction only]; Region: COG4087
548476007225	Zeta toxin; Region: Zeta_toxin; pfam06414
548476007226	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
548476007227	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
548476007228	NAD(P) binding site [chemical binding]; other site
548476007229	catalytic residues [active]
548476007230	Helix-turn-helix domain; Region: HTH_18; pfam12833
548476007231	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
548476007232	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
548476007233	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
548476007234	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
548476007235	succinic semialdehyde dehydrogenase; Region: PLN02278
548476007236	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
548476007237	tetramerization interface [polypeptide binding]; other site
548476007238	NAD(P) binding site [chemical binding]; other site
548476007239	catalytic residues [active]
548476007240	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
548476007241	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
548476007242	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
548476007243	N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266
548476007244	tetramer interface [polypeptide binding]; other site
548476007245	C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256
548476007246	tetramer interface [polypeptide binding]; other site
548476007247	active site
548476007248	metal binding site [ion binding]; metal-binding site
548476007249	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
548476007250	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
548476007251	NAD binding site [chemical binding]; other site
548476007252	catalytic residues [active]
548476007253	Transcriptional regulators [Transcription]; Region: GntR; COG1802
548476007254	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
548476007255	DNA-binding site [nucleotide binding]; DNA binding site
548476007256	FCD domain; Region: FCD; pfam07729
548476007257	hypothetical protein; Provisional; Region: PRK12764
548476007258	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
548476007259	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
548476007260	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548476007261	metabolite-proton symporter; Region: 2A0106; TIGR00883
548476007262	putative substrate translocation pore; other site
548476007263	phenol 2-monooxygenase; Provisional; Region: PRK08294
548476007264	FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979
548476007265	dimer interface [polypeptide binding]; other site
548476007266	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
548476007267	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548476007268	Walker A/P-loop; other site
548476007269	ATP binding site [chemical binding]; other site
548476007270	Q-loop/lid; other site
548476007271	ABC transporter signature motif; other site
548476007272	Walker B; other site
548476007273	D-loop; other site
548476007274	H-loop/switch region; other site
548476007275	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
548476007276	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
548476007277	TM-ABC transporter signature motif; other site
548476007278	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
548476007279	zinc binding site [ion binding]; other site
548476007280	putative ligand binding site [chemical binding]; other site
548476007281	anthranilate synthase component I; Provisional; Region: PRK13564
548476007282	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
548476007283	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
548476007284	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
548476007285	Glutamine amidotransferase class-I; Region: GATase; pfam00117
548476007286	glutamine binding [chemical binding]; other site
548476007287	catalytic triad [active]
548476007288	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
548476007289	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
548476007290	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
548476007291	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
548476007292	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
548476007293	active site
548476007294	ribulose/triose binding site [chemical binding]; other site
548476007295	phosphate binding site [ion binding]; other site
548476007296	substrate (anthranilate) binding pocket [chemical binding]; other site
548476007297	product (indole) binding pocket [chemical binding]; other site
548476007298	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
548476007299	active site
548476007300	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
548476007301	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
548476007302	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548476007303	catalytic residue [active]
548476007304	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
548476007305	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
548476007306	substrate binding site [chemical binding]; other site
548476007307	active site
548476007308	catalytic residues [active]
548476007309	heterodimer interface [polypeptide binding]; other site
548476007310	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
548476007311	active site
548476007312	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
548476007313	Integrase core domain; Region: rve; pfam00665
548476007314	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
548476007315	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
548476007316	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
548476007317	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
548476007318	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
548476007319	iron-sulfur cluster [ion binding]; other site
548476007320	[2Fe-2S] cluster binding site [ion binding]; other site
548476007321	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
548476007322	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
548476007323	phosphoribosylformylglycinamidine synthase; Provisional; Region: PLN03206
548476007324	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
548476007325	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
548476007326	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
548476007327	hypothetical protein; Validated; Region: PRK00228
548476007328	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
548476007329	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
548476007330	active site
548476007331	NTP binding site [chemical binding]; other site
548476007332	metal binding triad [ion binding]; metal-binding site
548476007333	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
548476007334	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
548476007335	Zn2+ binding site [ion binding]; other site
548476007336	Mg2+ binding site [ion binding]; other site
548476007337	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
548476007338	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
548476007339	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
548476007340	Uncharacterized conserved protein [Function unknown]; Region: COG2353
548476007341	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
548476007342	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
548476007343	Zn binding site [ion binding]; other site
548476007344	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
548476007345	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
548476007346	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
548476007347	DNA binding residues [nucleotide binding]
548476007348	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
548476007349	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
548476007350	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
548476007351	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
548476007352	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
548476007353	catalytic residues [active]
548476007354	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
548476007355	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
548476007356	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
548476007357	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
548476007358	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
548476007359	active site
548476007360	metal binding site [ion binding]; metal-binding site
548476007361	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
548476007362	ParB-like nuclease domain; Region: ParBc; pfam02195
548476007363	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
548476007364	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
548476007365	P-loop; other site
548476007366	Magnesium ion binding site [ion binding]; other site
548476007367	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
548476007368	Magnesium ion binding site [ion binding]; other site
548476007369	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
548476007370	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
548476007371	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548476007372	S-adenosylmethionine binding site [chemical binding]; other site
548476007373	putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449
548476007374	ribonuclease P; Reviewed; Region: rnpA; PRK03459
548476007375	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399