-- dump date 20111121_011513
-- class Genbank::misc_feature
-- table misc_feature_note
-- id note
293287000001 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
293287000002 P-loop; other site
293287000003 Transcriptional activator TraM; Region: Activator-TraM; cl11943
293287000004 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522
293287000005 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
293287000006 ParB-like partition proteins; Region: parB_part; TIGR00180
293287000007 ParB-like nuclease domain; Region: ParBc; cl02129
293287000008 KorB domain; Region: KorB; pfam08535
293287000009 KorB C-terminal beta-barrel domain; Region: KorB_C; pfam06613
293287000010 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
293287000011 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
293287000012 P-loop; other site
293287000013 Magnesium ion binding site; other site
293287000014 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
293287000015 Magnesium ion binding site; other site
293287000016 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
293287000017 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
293287000018 P-loop; other site
293287000019 Magnesium ion binding site; other site
293287000020 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
293287000021 Magnesium ion binding site; other site
293287000022 conjugal transfer protein TrbA; Provisional; Region: PRK13890
293287000023 Protein of unknown function (DUF2761); Region: DUF2761; pfam10959
293287000024 Antirestriction protein; Region: Antirestrict; pfam03230
293287000025 RelB antitoxin; Region: RelB; cl01171
293287000026 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
293287000027 Transposase; Region: Transposase_7; pfam01526
293287000028 Transposase and inactivated derivatives, TnpA family [DNA replication, recombination, and repair]; Region: COG4644
293287000029 Transposase and inactivated derivatives, TnpA family [DNA replication, recombination, and repair]; Region: COG4644
293287000030 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
293287000031 multiple promoter invertase; Provisional; Region: mpi; PRK13413
293287000032 catalytic residues; other site
293287000033 catalytic nucleophile; other site
293287000034 Presynaptic Site I dimer interface; other site
293287000035 Synaptic Antiparallel dimer interface; other site
293287000036 Synaptic Flat tetramer interface; other site
293287000037 Synaptic Site I dimer interface; other site
293287000038 DNA binding site
293287000039 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
293287000040 DNA-binding interface; DNA binding site
293287000041 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
293287000042 Chromate transporter; Region: Chromate_transp; cl00902
293287000043 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
293287000044 Chromate transporter; Region: Chromate_transp; cl00902
293287000045 Replication initiator protein A; Region: RPA; cl02339
293287000046 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
293287000047 dimer interface; other site
293287000048 ssDNA binding site; other site
293287000049 tetramer (dimer of dimers) interface; other site
293287000050 conjugal transfer protein TrbA; Provisional; Region: PRK13890
293287000051 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
293287000052 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
293287000053 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130
293287000054 ATP binding site; other site
293287000055 Walker A motif; other site
293287000056 hexamer interface; other site
293287000057 Walker B motif; other site
293287000058 TrbC/VIRB2 family; Region: TrbC; cl01583
293287000059 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
293287000060 conjugal transfer protein TrbE; Provisional; Region: PRK13891
293287000061 VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
293287000062 VirB8 protein; Region: VirB8; cl01500
293287000063 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
293287000064 VirB7 interaction site; other site
293287000065 conjugal transfer protein TrbH; Provisional; Region: PRK13883
293287000066 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
293287000067 Conjugal transfer protein TrbH; Region: TrbH; pfam07283
293287000068 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
293287000069 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314; cl02193
293287000070 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
293287000071 TrbM; Region: TrbM; cl06455
293287000072 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254
293287000073 N-acetyl-D-glucosamine binding site; other site
293287000074 catalytic residue; other site
293287000075 TraX protein; Region: TraX; cl05434
293287000076 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
293287000077 ligand binding site; other site
293287000078 Transposase; Region: Transposase_7; pfam01526
293287000079 Transposase and inactivated derivatives, TnpA family [DNA replication, recombination, and repair]; Region: COG4644
293287000080 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
293287000081 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
293287000082 amidohydrolase, AtzE family; Region: amido_AtzE; TIGR02715
293287000083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
293287000084 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
293287000085 active site 1
293287000086 dimer interface; other site
293287000087 hexamer interface; other site
293287000088 active site 2
293287000089 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
293287000090 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
293287000091 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
293287000092 delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237
293287000093 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
293287000094 NAD binding site; other site
293287000095 catalytic residues; other site
293287000096 mutated transporter gene; nonfunctional
293287000097 The alpha subunit of the Class III extradiol dioxygenase, 2-amino-5-chlorophenol 1,6-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of 2-amino-5-chlorophenol; Region: 2A5CPDO_A; cd07373
293287000098 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
293287000099 The beta subunit of the Class III extradiol dioxygenase, 2-amino-5-chlorophenol 1,6-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of 2-amino-5-chlorophenol; Region: 2A5CPDO_B; cd07372
293287000100 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
293287000101 putative active site; other site
293287000102 putative metal binding site; other site
293287000103 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
293287000104 homotrimer interaction site; other site
293287000105 putative active site; other site
293287000106 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
293287000107 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl01383
293287000108 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
293287000109 active site
293287000110 Muconolactone delta-isomerase; Region: MIase; cl01992
293287000111 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-...; Region: MLE; cd03318
293287000112 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
293287000113 octamer interface; other site
293287000114 active site
293287000115 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
293287000116 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
293287000117 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445
293287000118 dimerizarion interface; other site
293287000119 CrgA pocket; other site
293287000120 substrate binding pocket; other site
293287000121 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
293287000122 Transposase and inactivated derivatives, TnpA family [DNA replication, recombination, and repair]; Region: COG4644
293287000123 Transcriptional regulators [Transcription]; Region: GntR; COG1802
293287000124 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
293287000125 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
293287000126 NAD(P) binding site; other site
293287000127 catalytic residues; other site
293287000128 transposase based on nucleotide sequence but unknown protein based on predicted amino acids
293287000129 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
293287000130 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
293287000131 dimer interface; other site
293287000132 putative tRNA-binding site; other site
293287000133 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
293287000134 dimer interface; other site
293287000135 FMN binding site; other site
293287000136 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
293287000137 Protein of unknown function (DUF1311); Region: DUF1311; cl01530
293287000138 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
293287000139 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
293287000140 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a...; Region: Nitroreductase; cd02136
293287000141 putative FMN binding site; other site
293287000142 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
293287000143 Putative transposase; Region: Transposase_32; pfam04986
293287000144 Domain of unknown function; Region: DUF300; pfam03619
293287000145 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
293287000146 catalytic residues; other site
293287000147 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
293287000148 transmembrane helices; other site
293287000149 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
293287000150 Low molecular weight phosphatase family; Region: LMWPc; cd00115
293287000151 active site
293287000152 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
293287000153 putative DNA binding site; other site
293287000154 putative Zn2+ binding site; other site
293287000155 dimerization interface; other site
293287000156 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
293287000157 Putative transposase; Region: Transposase_32; pfam04986
293287000158 Transposase; Region: Transposase_7; pfam01526
293287000159 Transposase and inactivated derivatives, TnpA family [DNA replication, recombination, and repair]; Region: COG4644
293287000160 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
293287000161 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
293287000162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
293287000163 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication...; Region: TOPRIM_primases; cd01029
293287000164 active site
293287000165 metal-binding site
293287000166 interdomain interaction site; other site
293287000167 DNA topoisomerase III; Validated; Region: PRK08174
293287000168 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by...; Region: TOPRIM_TopoIA_TopoIII; cd03362
293287000169 active site
293287000170 putative interdomain interaction site; other site
293287000171 putative metal-binding site; other site
293287000172 putative nucleotide binding site; other site
293287000173 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186
293287000174 domain I; other site
293287000175 DNA binding groove
293287000176 phosphate binding site; other site
293287000177 domain II; other site
293287000178 domain III; other site
293287000179 nucleotide binding site; other site
293287000180 catalytic site; other site
293287000181 domain IV; other site
293287000182 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977
293287000183 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88)...; Region: Peptidase_S24_S26; cl10465
293287000184 Peptidase S26; Region: Peptidase_S26; pfam10502
293287000185 TraG/TraD family; Region: TraG; pfam02534
293287000186 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
293287000187 Walker A motif; other site
293287000188 ATP binding site; other site
293287000189 Walker B motif; other site
293287000190 conjugal transfer relaxase TraI; Provisional; Region: PRK13878
293287000191 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584
293287000192 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877
688245000193 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
688245000194 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245000195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245000196 Walker A motif; other site
688245000197 ATP binding site; other site
688245000198 Walker B motif; other site
688245000199 arginine finger; other site
688245000200 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
688245000201 DnaA box-binding interface; other site
688245000202 DNA polymerase III subunit beta; Validated; Region: PRK05643
688245000203 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140
688245000204 putative DNA binding surface; other site
688245000205 dimer interface; other site
688245000206 beta-clamp/clamp loader binding surface; other site
688245000207 beta-clamp/translesion DNA polymerase binding surface; other site
688245000208 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
688245000209 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245000210 ATP binding site; other site
688245000211 Mg2+ binding site; other site
688245000212 G-X-G motif; other site
688245000213 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822
688245000214 anchoring element; other site
688245000215 dimer interface; other site
688245000216 ATP binding site; other site
688245000217 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366
688245000218 active site
688245000219 putative metal-binding site; other site
688245000220 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
688245000221 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245000222 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245000223 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
688245000224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245000225 Putative cyclase; Region: Cyclase; cl00814
688245000226 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
688245000227 DUF35 OB-fold domain; Region: DUF35; pfam01796
688245000228 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245000229 short chain dehydrogenase; Validated; Region: PRK08264
688245000230 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl...; Region: SCP-x_thiolase; cd00829
688245000231 acetyl-CoA acetyltransferase; Provisional; Region: PRK12578
688245000232 active site
688245000233 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245000234 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155
688245000235 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245000236 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
688245000237 inter-subunit interface; other site
688245000238 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228
688245000239 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938
688245000240 iron-sulfur cluster; other site
688245000241 [2Fe-2S] cluster binding site; other site
688245000242 Ring hydroxylating alpha subunit (catalytic domain). This CD includes the catalytic domain (alpha) of aromatic-ring-hydroxylating dioxygenase systems of eubacteria. Eubacterial ring hydroxylating dioxygenases are multicomponent 1,2-dioxygenase...; Region: Ring_hydroxylating_alpha; cd00680
688245000243 interface residues; other site
688245000244 active site
688245000245 substrate binding pocket; other site
688245000246 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245000247 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
688245000248 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron...; Region: PDR_like; cd06185
688245000249 FMN-binding pocket; other site
688245000250 flavin binding motif; other site
688245000251 phosphate binding motif; other site
688245000252 beta-alpha-beta structure motif; other site
688245000253 NAD binding pocket; other site
688245000254 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
688245000255 catalytic loop; other site
688245000256 iron binding site; other site
688245000257 putative indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK08312
688245000258 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
688245000259 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231
688245000260 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
688245000261 dimer interface; other site
688245000262 PYR/PP interface; other site
688245000263 TPP binding site; other site
688245000264 substrate binding site; other site
688245000265 TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as indolepyruvate or phenylpyruvate, which are generated by the...; Region: TPP_IOR_alpha; cd02008
688245000266 TPP-binding site; other site
688245000267 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Beta; cd03057
688245000268 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
688245000269 C-terminal domain interface; other site
688245000270 GSH binding site (G-site); other site
688245000271 dimer interface; other site
688245000272 GST_C family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_C_Beta; cd03188
688245000273 dimer interface; other site
688245000274 N-terminal domain interface; other site
688245000275 substrate binding pocket (H-site); other site
688245000276 Uncharacterized protein family (UPF0153); Region: UPF0153; cl00497
688245000277 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
688245000278 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
688245000279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245000280 ATP binding site; other site
688245000281 Mg2+ binding site; other site
688245000282 G-X-G motif; other site
688245000283 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
688245000284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245000285 active site
688245000286 phosphorylation site
688245000287 intermolecular recognition site; other site
688245000288 dimerization interface; other site
688245000289 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
688245000290 DNA binding site
688245000291 Outer membrane efflux protein; Region: OEP; pfam02321
688245000292 Outer membrane efflux protein; Region: OEP; pfam02321
688245000293 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
688245000294 pyruvate carboxylase; Reviewed; Region: PRK12999
688245000295 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
688245000296 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
688245000297 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl12029
688245000298 helicase superfamily c-terminal domain; Region: HELICc2; cl09250
688245000299 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
688245000300 Domain of Unknown Function (DUF1520); Region: DUF1520; pfam07480
688245000301 Putative exonuclease, RdgC; Region: RdgC; cl01122
688245000302 beta-ketothiolase; Provisional; Region: PRK09051
688245000303 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
688245000304 dimer interface; other site
688245000305 active site
688245000306 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
688245000307 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
688245000308 DNA binding residues
688245000309 dimer interface; other site
688245000310 copper binding site; other site
688245000311 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
688245000312 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
688245000313 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144
688245000314 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
688245000315 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
688245000316 FMN binding site; other site
688245000317 active site
688245000318 substrate binding site; other site
688245000319 catalytic residue; other site
688245000320 glutathionine S-transferase; Provisional; Region: PRK10542
688245000321 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Beta; cd03057
688245000322 C-terminal domain interface; other site
688245000323 GSH binding site (G-site); other site
688245000324 dimer interface; other site
688245000325 GST_C family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_C_Beta; cd03188
688245000326 N-terminal domain interface; other site
688245000327 dimer interface; other site
688245000328 substrate binding pocket (H-site); other site
688245000329 NADPH-dependent FMN reductase; Region: FMN_red; cl00438
688245000330 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
688245000331 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520
688245000332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245000333 LysE type translocator; Region: LysE; cl00565
688245000334 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
688245000335 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
688245000336 P-loop; other site
688245000337 Magnesium ion binding site; other site
688245000338 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras; Region: Ras_like_GTPase; cl10444
688245000339 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
688245000340 Magnesium ion binding site; other site
688245000341 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245000342 ParB-like partition proteins; Region: parB_part; TIGR00180
688245000343 ParB-like nuclease domain; Region: ParBc; cl02129
688245000344 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214
688245000345 intersubunit interface; other site
688245000346 active site
688245000347 Zn2+ binding site; other site
688245000348 Peptidase dimerization domain; Region: M20_dimer; cl09126
688245000349 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
688245000350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245000351 Major Facilitator Superfamily; Region: MFS_1; pfam07690
688245000352 putative substrate translocation pore; other site
688245000353 Cupin domain; Region: Cupin_2; cl09118
688245000354 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
688245000355 RNA polymerase sigma factor; Provisional; Region: PRK11924
688245000356 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
688245000357 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
688245000358 DNA binding residues
688245000359 sulfite oxidase (SOX); Provisional; Region: PLN00177
688245000360 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
688245000361 Moco binding site; other site
688245000362 metal coordination site; other site
688245000363 dimerization interface; other site
688245000364 Cytochrome c; Region: Cytochrom_C; cl11414
688245000365 Sel1 repeat; Region: Sel1; cl02723
688245000366 FAD binding domain; Region: FAD_binding_4; cl10516
688245000367 D-lactate dehydrogenase; Region: PLN02805
688245000368 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245000369 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
688245000370 putative ligand binding site; other site
688245000371 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading...; Region: EFh; cd00051
688245000372 Ca2+ binding site; other site
688245000373 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
688245000374 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
688245000375 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245000376 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245000377 dimerization interface; other site
688245000378 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245000379 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409
688245000380 potential frameshift: common BLAST hit: gi|160895520|ref|YP_001561102.1| extracellular solute-binding protein
688245000381 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
688245000382 substrate binding pocket; other site
688245000383 membrane-bound complex binding site; other site
688245000384 hinge residues; other site
688245000385 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245000386 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
688245000387 aspartate racemase; Region: asp_race; TIGR00035
688245000388 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
688245000389 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224
688245000390 4Fe-4S binding domain; Region: Fer4; pfam00037
688245000391 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208
688245000392 dimerization interface; other site
688245000393 FAD binding pocket; other site
688245000394 FAD binding motif; other site
688245000395 catalytic residues; other site
688245000396 NAD binding pocket; other site
688245000397 phosphate binding motif; other site
688245000398 beta-alpha-beta structure motif; other site
688245000399 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346
688245000400 benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184
688245000401 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
688245000402 substrate binding site; other site
688245000403 oxyanion hole (OAH) forming residues; other site
688245000404 trimer interface; other site
688245000405 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cl11392
688245000406 substrate binding site; other site
688245000407 trimer interface; other site
688245000408 oxyanion hole (OAH) forming residues; other site
688245000409 threonine dehydratase; Provisional; Region: PRK07334
688245000410 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
688245000411 tetramer interface; other site
688245000412 pyridoxal 5'-phosphate binding site; other site
688245000413 catalytic residue; other site
688245000414 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
688245000415 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
688245000416 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
688245000417 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821
688245000418 active site
688245000419 substrate-binding site; other site
688245000420 metal-binding site
688245000421 GTP binding site; other site
688245000422 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245000423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245000424 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
688245000425 substrate binding pocket; other site
688245000426 dimerization interface; other site
688245000427 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
688245000428 active site
688245000429 metal-binding site
688245000430 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
688245000431 Ligand Binding Site; other site
688245000432 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
688245000433 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245000434 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245000435 dimerization interface; other site
688245000436 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245000437 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409
688245000438 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245000439 Transcriptional regulators [Transcription]; Region: MarR; COG1846
688245000440 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
688245000441 Flavin Reductases; Region: FlaRed; cl00801
688245000442 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
688245000443 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184
688245000444 glutathione reductase; Validated; Region: PRK06116
688245000445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245000446 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
688245000447 Septum formation topological specificity factor MinE; Region: MinE; cl00538
688245000448 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
688245000449 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a...; Region: MinD; cd02036
688245000450 Switch I; other site
688245000451 Switch II; other site
688245000452 septum formation inhibitor; Reviewed; Region: PRK01973
688245000453 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
688245000454 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
688245000455 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
688245000456 enoyl-CoA hydratase; Provisional; Region: PRK06142
688245000457 substrate binding site; other site
688245000458 oxyanion hole (OAH) forming residues; other site
688245000459 trimer interface; other site
688245000460 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
688245000461 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
688245000462 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245000463 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
688245000464 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293
688245000465 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056
688245000466 Permease family; Region: Xan_ur_permease; cl00967
688245000467 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
688245000468 succinate CoA transferases; Region: YgfH_subfam; TIGR03458
688245000469 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
688245000470 CoenzymeA binding site; other site
688245000471 subunit interaction site; other site
688245000472 PHB binding site; other site
688245000473 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
688245000474 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
688245000475 Walker A/P-loop; other site
688245000476 ATP binding site; other site
688245000477 Q-loop/lid; other site
688245000478 ABC transporter signature motif; other site
688245000479 Walker B; other site
688245000480 D-loop; other site
688245000481 H-loop/switch region; other site
688245000482 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
688245000483 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219
688245000484 Walker A/P-loop; other site
688245000485 ATP binding site; other site
688245000486 Q-loop/lid; other site
688245000487 ABC transporter signature motif; other site
688245000488 Walker B; other site
688245000489 D-loop; other site
688245000490 H-loop/switch region; other site
688245000491 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
688245000492 TM-ABC transporter signature motif; other site
688245000493 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
688245000494 TM-ABC transporter signature motif; other site
688245000495 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
688245000496 Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360
688245000497 putative ligand binding site; other site
688245000498 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262
688245000499 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245000500 aldehyde dehydrogenase; Provisional; Region: PRK11903
688245000501 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
688245000502 NAD(P) binding site; other site
688245000503 catalytic residues; other site
688245000504 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154
688245000505 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464
688245000506 ADP binding site; other site
688245000507 magnesium binding site; other site
688245000508 putative shikimate binding site; other site
688245000509 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
688245000510 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245000511 active site
688245000512 Peptidase family M48; Region: Peptidase_M48; cl12018
688245000513 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
688245000514 EamA-like transporter family; Region: EamA; cl01037
688245000515 Cupin domain; Region: Cupin_2; cl09118
688245000516 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
688245000517 muropeptide transporter; Reviewed; Region: ampG; PRK11902
688245000518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
688245000519 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
688245000520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245000521 active site
688245000522 phosphorylation site
688245000523 intermolecular recognition site; other site
688245000524 dimerization interface; other site
688245000525 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
688245000526 DNA binding site
688245000527 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
688245000528 dimerization interface; other site
688245000529 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans...; Region: HisKA; cd00082
688245000530 dimer interface; other site
688245000531 phosphorylation site
688245000532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245000533 ATP binding site; other site
688245000534 Mg2+ binding site; other site
688245000535 G-X-G motif; other site
688245000536 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
688245000537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245000538 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
688245000539 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
688245000540 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
688245000541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245000542 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
688245000543 Transposase DDE domain; Region: Transposase_11; pfam01609
688245000544 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
688245000545 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
688245000546 Ligand binding site; other site
688245000547 Putative Catalytic site; other site
688245000548 DXD motif; other site
688245000549 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
688245000550 O-Antigen ligase; Region: Wzy_C; cl04850
688245000551 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
688245000552 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
688245000553 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
688245000554 putative ADP-binding pocket; other site
688245000555 Zinc-finger domain; Region: zf-CHCC; cl01821
688245000556 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557
688245000557 homodimer interface; other site
688245000558 substrate-cofactor binding pocket; other site
688245000559 Aminotransferase class IV; Region: Aminotran_4; pfam01063
688245000560 catalytic residue; other site
688245000561 DNA repair protein RadA; Provisional; Region: PRK11823
688245000562 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
688245000563 Walker A motif/ATP binding site; other site
688245000564 ATP binding site; other site
688245000565 Walker B motif; other site
688245000566 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
688245000567 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
688245000568 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812
688245000569 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
688245000570 NAD(P) binding site; other site
688245000571 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
688245000572 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
688245000573 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245000574 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245000575 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
688245000576 dimerization interface; other site
688245000577 Predicted membrane protein [Function unknown]; Region: COG4125
688245000578 Bacterial Transmembrane Pair family; Region: BTP; pfam05232
688245000579 Bacterial Transmembrane Pair family; Region: BTP; pfam05232
688245000580 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; cl12073
688245000581 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616
688245000582 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
688245000583 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740
688245000584 substrate binding pocket; other site
688245000585 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
688245000586 B12 binding site; other site
688245000587 cobalt ligand; other site
688245000588 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
688245000589 Transcriptional regulators [Transcription]; Region: GntR; COG1802
688245000590 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245000591 DNA binding site
688245000592 FCD domain; Region: FCD; cl11656
688245000593 Sodium:dicarboxylate symporter family; Region: SDF; cl00573
688245000594 cardiolipin synthetase; Reviewed; Region: cls; PRK01642
688245000595 Phospholipase D. Active site motifs; The PLD superfamily includes enzymes involved in signal transduction, lipid biosynthesis, endonucleases and open reading frames in pathogenic viruses and bacteria. PLD hydrolyzes the terminal phosphodiester bond of...; Region: PLDc; cd00138
688245000596 active site
688245000597 signature motif; other site
688245000598 Phospholipase D. Active site motifs; The PLD superfamily includes enzymes involved in signal transduction, lipid biosynthesis, endonucleases and open reading frames in pathogenic viruses and bacteria. PLD hydrolyzes the terminal phosphodiester bond of...; Region: PLDc; cd00138
688245000599 active site
688245000600 signature motif; other site
688245000601 Ammonium Transporter Family; Region: Ammonium_transp; cl03012
688245000602 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
688245000603 active site
688245000604 catalytic site; other site
688245000605 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
688245000606 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
688245000607 pyridoxal 5'-phosphate binding site; other site
688245000608 catalytic residue; other site
688245000609 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067
688245000610 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880
688245000611 G1 box; other site
688245000612 GTP/Mg2+ binding site; other site
688245000613 Switch I region; other site
688245000614 G2 box; other site
688245000615 Switch II region; other site
688245000616 G3 box; other site
688245000617 G4 box; other site
688245000618 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
688245000619 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080
688245000620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245000621 ATP binding site; other site
688245000622 Mg2+ binding site; other site
688245000623 G-X-G motif; other site
688245000624 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
688245000625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245000626 active site
688245000627 phosphorylation site
688245000628 intermolecular recognition site; other site
688245000629 dimerization interface; other site
688245000630 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
688245000631 DNA binding site
688245000632 NodT family; Region: outer_NodT; TIGR01845
688245000633 Outer membrane efflux protein; Region: OEP; pfam02321
688245000634 Predicted permease; Region: FtsX; cl11418
688245000635 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
688245000636 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
688245000637 Walker A/P-loop; other site
688245000638 ATP binding site; other site
688245000639 Q-loop/lid; other site
688245000640 ABC transporter signature motif; other site
688245000641 Walker B; other site
688245000642 D-loop; other site
688245000643 H-loop/switch region; other site
688245000644 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
688245000645 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
688245000646 Esterase/lipase [General function prediction only]; Region: COG1647
688245000647 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
688245000648 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
688245000649 pyridoxal 5'-phosphate binding pocket; other site
688245000650 catalytic residue; other site
688245000651 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
688245000652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245000653 domain; Region: Succ_DH_flav_C; pfam02910
688245000654 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
688245000655 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
688245000656 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245000657 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
688245000658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245000659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
688245000660 S-adenosylmethionine binding site; other site
688245000661 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610
688245000662 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
688245000663 inhibitor-cofactor binding pocket; inhibition site
688245000664 pyridoxal 5'-phosphate binding site; other site
688245000665 catalytic residue; other site
688245000666 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
688245000667 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
688245000668 ATP binding site; other site
688245000669 putative Mg++ binding site; other site
688245000670 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
688245000671 nucleotide binding region; other site
688245000672 ATP-binding site; other site
688245000673 RQC domain; Region: RQC; pfam09382
688245000674 HRDC domain; Region: HRDC; cl02578
688245000675 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
688245000676 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245000677 DNA binding site
688245000678 UTRA domain; Region: UTRA; cl06649
688245000679 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
688245000680 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245000681 active site
688245000682 CoA-transferase family III; Region: CoA_transf_3; cl00778
688245000683 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245000684 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245000685 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245000686 dimerization interface; other site
688245000687 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184
688245000688 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245000689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245000690 dimer interface; other site
688245000691 conserved gate region; other site
688245000692 ABC-ATPase subunit interface; other site
688245000693 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
688245000694 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293
688245000695 Walker A/P-loop; other site
688245000696 ATP binding site; other site
688245000697 Q-loop/lid; other site
688245000698 ABC transporter signature motif; other site
688245000699 Walker B; other site
688245000700 D-loop; other site
688245000701 H-loop/switch region; other site
688245000702 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
688245000703 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245000704 DNA binding site
688245000705 UTRA domain; Region: UTRA; cl06649
688245000706 tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832
688245000707 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
688245000708 active sites
688245000709 tetramer interface; other site
688245000710 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
688245000711 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245000712 DNA binding site
688245000713 UTRA domain; Region: UTRA; cl06649
688245000714 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
688245000715 Sodium:solute symporter family; Region: SSF; cl00456
688245000716 urocanate hydratase; Provisional; Region: PRK05414
688245000717 urocanate hydratase; Region: hutU; TIGR01228
688245000718 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
688245000719 Peptidase dimerization domain; Region: M20_dimer; cl09126
688245000720 HutD; Region: HutD; cl01532
688245000721 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
688245000722 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria...; Region: Imidazolone-5PH; cd01296
688245000723 active site
688245000724 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
688245000725 FAD binding domain; Region: FAD_binding_4; cl10516
688245000726 histidinol-phosphate aminotransferase; Provisional; Region: PRK05166
688245000727 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688245000728 pyridoxal 5'-phosphate binding site; other site
688245000729 homodimer interface; other site
688245000730 catalytic residue; other site
688245000731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245000732 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
688245000733 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313
688245000734 active site
688245000735 N-formylglutamate amidohydrolase; Region: FGase; cl01522
688245000736 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
688245000737 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
688245000738 DNA binding residues
688245000739 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
688245000740 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
688245000741 NodT family; Region: outer_NodT; TIGR01845
688245000742 Outer membrane efflux protein; Region: OEP; pfam02321
688245000743 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206
688245000744 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
688245000745 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105
688245000746 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342
688245000747 trimer interface; other site
688245000748 eyelet of channel; other site
688245000749 biotin synthetase; Region: bioB; TIGR00433
688245000750 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
688245000751 FeS/SAM binding site; other site
688245000752 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
688245000753 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943
688245000754 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
688245000755 inhibitor-cofactor binding pocket; inhibition site
688245000756 pyridoxal 5'-phosphate binding site; other site
688245000757 catalytic residue; other site
688245000758 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
688245000759 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras; Region: Ras_like_GTPase; cl10444
688245000760 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
688245000761 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
688245000762 pyridoxal 5'-phosphate binding pocket; other site
688245000763 catalytic residue; other site
688245000764 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
688245000765 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245000766 DNA binding site
688245000767 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688245000768 pyridoxal 5'-phosphate binding site; other site
688245000769 homodimer interface; other site
688245000770 catalytic residue; other site
688245000771 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
688245000772 Permease family; Region: Xan_ur_permease; cl00967
688245000773 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
688245000774 pyridoxal 5'-phosphate (PLP) binding site; other site
688245000775 catalytic residue; other site
688245000776 acetylornithine aminotransferase; Provisional; Region: PRK02627
688245000777 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
688245000778 inhibitor-cofactor binding pocket; inhibition site
688245000779 pyridoxal 5'-phosphate binding site; other site
688245000780 catalytic residue; other site
688245000781 alanine racemase; Reviewed; Region: dadX; PRK03646
688245000782 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
688245000783 active site
688245000784 pyridoxal 5'-phosphate (PLP) binding site; other site
688245000785 substrate binding site; other site
688245000786 catalytic residues; other site
688245000787 dimer interface; other site
688245000788 lysophospholipid transporter LplT; Provisional; Region: PRK11195
688245000789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245000790 putative substrate translocation pore; other site
688245000791 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293
688245000792 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
688245000793 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
688245000794 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cd00216
688245000795 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
688245000796 Trp docking motif; other site
688245000797 'Velcro' closure; other site
688245000798 active site
688245000799 Cytochrome c; Region: Cytochrom_C; cl11414
688245000800 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
688245000801 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
688245000802 NAD binding site; other site
688245000803 catalytic residues; other site
688245000804 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl00174
688245000805 putative RNA binding sites; other site
688245000806 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
688245000807 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl00255
688245000808 Cysteine-rich domain; Region: CCG; pfam02754
688245000809 Cysteine-rich domain; Region: CCG; pfam02754
688245000810 FAD binding domain; Region: FAD_binding_4; cl10516
688245000811 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
688245000812 Ammonium Transporter Family; Region: Ammonium_transp; cl03012
688245000813 Nitrogen regulatory protein P-II; Region: P-II; cl00412
688245000814 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
688245000815 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
688245000816 Sulfatase; Region: Sulfatase; cl10460
688245000817 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245000818 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245000819 Transcriptional regulators [Transcription]; Region: MarR; COG1846
688245000820 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245000821 Mg chelatase-related protein; Region: TIGR00368
688245000822 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245000823 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245000824 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245000825 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245000826 dimerization interface; other site
688245000827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245000828 putative substrate translocation pore; other site
688245000829 2-nitropropane dioxygenase; Region: NPD; pfam03060
688245000830 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730
688245000831 FMN binding site; other site
688245000832 substrate binding site; other site
688245000833 putative catalytic residue; other site
688245000834 feruloyl-CoA synthase; Reviewed; Region: PRK08180
688245000835 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245000836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245000837 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
688245000838 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
688245000839 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
688245000840 putative ligand binding site; other site
688245000841 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl01276
688245000842 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
688245000843 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
688245000844 ligand binding site; other site
688245000845 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245000846 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245000847 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
688245000848 putative dimerization interface; other site
688245000849 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245000850 Uncharacterized conserved protein [Function unknown]; Region: COG3777
688245000851 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
688245000852 active site 2
688245000853 active site 1
688245000854 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
688245000855 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245000856 active site
688245000857 CoA-transferase family III; Region: CoA_transf_3; cl00778
688245000858 MmgE/PrpD family; Region: MmgE_PrpD; cl00912
688245000859 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245000860 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl09155
688245000861 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245000862 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
688245000863 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
688245000864 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
688245000865 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
688245000866 Walker A/P-loop; other site
688245000867 ATP binding site; other site
688245000868 Q-loop/lid; other site
688245000869 ABC transporter signature motif; other site
688245000870 Walker B; other site
688245000871 D-loop; other site
688245000872 H-loop/switch region; other site
688245000873 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
688245000874 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219
688245000875 Walker A/P-loop; other site
688245000876 ATP binding site; other site
688245000877 Q-loop/lid; other site
688245000878 ABC transporter signature motif; other site
688245000879 Walker B; other site
688245000880 D-loop; other site
688245000881 H-loop/switch region; other site
688245000882 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
688245000883 TM-ABC transporter signature motif; other site
688245000884 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
688245000885 TM-ABC transporter signature motif; other site
688245000886 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
688245000887 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330
688245000888 putative ligand binding site; other site
688245000889 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
688245000890 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
688245000891 FAD binding pocket; other site
688245000892 FAD binding motif; other site
688245000893 phosphate binding motif; other site
688245000894 beta-alpha-beta structure motif; other site
688245000895 NAD binding pocket; other site
688245000896 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918
688245000897 succinate CoA transferases; Region: YgfH_subfam; TIGR03458
688245000898 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
688245000899 galactarate dehydratase; Region: galactar-dH20; TIGR03248
688245000900 SAF domain; Region: SAF; cl00555
688245000901 SAF domain; Region: SAF; cl00555
688245000902 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245000903 glucarate dehydratase; Region: glucar-dehydr; TIGR03247
688245000904 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of...; Region: D-glucarate_dehydratase; cd03323
688245000905 active site
688245000906 tetramer interface; other site
688245000907 Transcriptional regulators [Transcription]; Region: FadR; COG2186
688245000908 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245000909 DNA binding site
688245000910 FCD domain; Region: FCD; cl11656
688245000911 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245000912 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
688245000913 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH), which is member of dihydrodipicolinate synthase (DHDPS) family that comprises several pyruvate-dependent class I aldolases. The enzyme is involved in...; Region: KDGDH; cd00951
688245000914 putative active site; other site
688245000915 catalytic residue; other site
688245000916 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245000917 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
688245000918 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245000919 glucarate dehydratase; Region: glucar-dehydr; TIGR03247
688245000920 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of...; Region: D-glucarate_dehydratase; cd03323
688245000921 active site
688245000922 tetramer interface; other site
688245000923 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
688245000924 delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237
688245000925 NAD(P) binding site; other site
688245000926 catalytic residues; other site
688245000927 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10632
688245000928 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245000929 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
688245000930 putative effector binding pocket; other site
688245000931 dimerization interface; other site
688245000932 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
688245000933 DSBA-like thioredoxin domain; Region: DSBA; pfam01323
688245000934 Putative cyclase; Region: Cyclase; cl00814
688245000935 LrgB-like family; Region: LrgB; cl00596
688245000936 LrgA family; Region: LrgA; cl00608
688245000937 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
688245000938 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245000939 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245000940 dimerization interface; other site
688245000941 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130
688245000942 pseudouridine synthase; Region: TIGR00093
688245000943 active site
688245000944 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
688245000945 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
688245000946 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222
688245000947 NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566
688245000948 LysE type translocator; Region: LysE; cl00565
688245000949 Transcriptional regulators [Transcription]; Region: Lrp; COG1522
688245000950 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245000951 Multicopper oxidase; Region: Cu-oxidase; cl11412
688245000952 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; cl00490
688245000953 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
688245000954 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
688245000955 HPP family; Region: HPP; pfam04982
688245000956 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010
688245000957 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
688245000958 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
688245000959 putative FMN binding site; other site
688245000960 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
688245000961 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245000962 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
688245000963 L-serine binding site; other site
688245000964 ACT domain interface; other site
688245000965 Predicted membrane protein [Function unknown]; Region: COG1297; cl14607
688245000966 putative oligopeptide transporter, OPT family; Region: TIGR00733
688245000967 Domain of unknown function (DUF1508); Region: DUF1508; cl01356
688245000968 Domain of unknown function (DUF1508); Region: DUF1508; cl01356
688245000969 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245000970 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
688245000971 GatB/GatE catalytic domain; Region: GatB_N; pfam02934
688245000972 GatB domain; Region: GatB_Yqey; cl11497
688245000973 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
688245000974 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
688245000975 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
688245000976 rod shape-determining protein MreB; Provisional; Region: PRK13927
688245000977 Cell division protein FtsA; Region: FtsA; cl11496
688245000978 rod shape-determining protein MreC; Provisional; Region: PRK13922
688245000979 rod shape-determining protein MreC; Region: MreC; pfam04085
688245000980 rod shape-determining protein MreD; Region: MreD; cl01087
688245000981 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
688245000982 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
688245000983 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
688245000984 Sulfite exporter TauE/SafE; Region: TauE; cl00498
688245000985 choline dehydrogenase; Validated; Region: PRK02106
688245000986 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
688245000987 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
688245000988 Domain of unknown function DUF140; Region: DUF140; cl00510
688245000989 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
688245000990 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245000991 Walker A/P-loop; other site
688245000992 ATP binding site; other site
688245000993 Q-loop/lid; other site
688245000994 ABC transporter signature motif; other site
688245000995 Walker B; other site
688245000996 D-loop; other site
688245000997 H-loop/switch region; other site
688245000998 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
688245000999 mce related protein; Region: MCE; pfam02470
688245001000 cation-binding hemerythrin HHE family protein; Provisional; Region: PRK01917
688245001001 MarC family integral membrane protein; Region: MarC; cl00919
688245001002 Dienelactone hydrolase family; Region: DLH; pfam01738
688245001003 CorA-like Mg2+ transporter protein; Region: CorA; cl00459
688245001004 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
688245001005 dimer interface; other site
688245001006 allosteric magnesium binding site; other site
688245001007 active site
688245001008 aspartate-rich active site metal binding site; other site
688245001009 Schiff base residues; other site
688245001010 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
688245001011 VanZ like family; Region: VanZ; cl01971
688245001012 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH...; Region: TRX_Fd_family; cd02980
688245001013 dimer interface; other site
688245001014 [2Fe-2S] cluster binding site; other site
688245001015 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
688245001016 potential frameshift: common BLAST hit: gi|160895834|ref|YP_001561416.1| Serine-type D-Ala-D-Ala carboxypeptidase
688245001017 Beta-lactamase; Region: Beta-lactamase; cl01009
688245001018 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
688245001019 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
688245001020 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
688245001021 streptomycin interaction site; other site
688245001022 23S rRNA interaction site; other site
688245001023 aminoacyl-tRNA interaction site (A-site); other site
688245001024 16S rRNA interaction site; other site
688245001025 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
688245001026 elongation factor G; Reviewed; Region: PRK00007
688245001027 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886
688245001028 G1 box; other site
688245001029 putative GEF interaction site; other site
688245001030 GTP/Mg2+ binding site; other site
688245001031 Switch I region; other site
688245001032 G2 box; other site
688245001033 G3 box; other site
688245001034 Switch II region; other site
688245001035 G4 box; other site
688245001036 G5 box; other site
688245001037 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088
688245001038 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434
688245001039 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713
688245001040 elongation factor Tu; Reviewed; Region: PRK12735
688245001041 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors...; Region: EF_Tu; cd01884
688245001042 G1 box; other site
688245001043 GEF interaction site; other site
688245001044 GTP/Mg2+ binding site; other site
688245001045 Switch I region; other site
688245001046 G2 box; other site
688245001047 G3 box; other site
688245001048 Switch II region; other site
688245001049 G4 box; other site
688245001050 G5 box; other site
688245001051 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
688245001052 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707
688245001053 Antibiotic Binding Site; other site
688245001054 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
688245001055 Ribosomal protein L3; Region: Ribosomal_L3; cl00324
688245001056 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
688245001057 Ribosomal protein L23; Region: Ribosomal_L23; cl00326
688245001058 50S ribosomal protein L2; Validated; Region: rplB; PRK09374
688245001059 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
688245001060 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
688245001061 Ribosomal protein S19; Region: Ribosomal_S19; cl00350
688245001062 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
688245001063 putative translocon binding site; other site
688245001064 protein-rRNA interface; other site
688245001065 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
688245001066 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412
688245001067 G-X-X-G motif; other site
688245001068 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
688245001069 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
688245001070 23S rRNA interface; other site
688245001071 5S rRNA interface; other site
688245001072 putative antibiotic binding site; other site
688245001073 L25 interface; other site
688245001074 L27 interface; other site
688245001075 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427
688245001076 23S rRNA interface; other site
688245001077 putative translocon interaction site; other site
688245001078 signal recognition particle (SRP54) interaction site; other site
688245001079 L23 interface; other site
688245001080 trigger factor interaction site; other site
688245001081 Ribosomal protein S17; Region: Ribosomal_S17; cl00351
688245001082 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
688245001083 catalytic triad; other site
688245001084 dimer interface; other site
688245001085 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
688245001086 Coenzyme A binding pocket; other site
688245001087 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
688245001088 Cytochrome C'; Region: Cytochrom_C_2; cl01610
688245001089 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966
688245001090 catalytic residues; other site
688245001091 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cl00025
688245001092 active pocket/dimerization site; other site
688245001093 active site
688245001094 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
688245001095 regulatory protein interface; other site
688245001096 active site
688245001097 regulatory phosphorylation site; other site
688245001098 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
688245001099 PEP-utilising enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524
688245001100 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
688245001101 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl09155
688245001102 Domain of unknown function (DUF1963); Region: DUF1963; cl01600
688245001103 lipoyl synthase; Provisional; Region: PRK05481
688245001104 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
688245001105 FeS/SAM binding site; other site
688245001106 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
688245001107 Protein of unknown function (DUF493); Region: DUF493; cl01102
688245001108 ATP synthase A chain; Region: ATP-synt_A; cl00413
688245001109 ATP synthase subunit C; Region: ATP-synt_C; cl00466
688245001110 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
688245001111 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
688245001112 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl00491
688245001113 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
688245001114 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
688245001115 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
688245001116 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
688245001117 beta subunit interaction interface; other site
688245001118 Walker A motif; other site
688245001119 ATP binding site; other site
688245001120 Walker B motif; other site
688245001121 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
688245001122 ATP synthase; Region: ATP-synt; cl00365
688245001123 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
688245001124 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
688245001125 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
688245001126 alpha subunit interaction interface; other site
688245001127 Walker A motif; other site
688245001128 ATP binding site; other site
688245001129 Walker B motif; other site
688245001130 inhibitor binding site; inhibition site
688245001131 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
688245001132 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
688245001133 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
688245001134 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458
688245001135 DNA binding site
688245001136 RNA-binding motif; other site
688245001137 Protein of unknown function (DUF1294); Region: DUF1294; cl01311
688245001138 Domain of unknown function (DUF477); Region: DUF477; cl01535
688245001139 Domain of unknown function (DUF477); Region: DUF477; cl01535
688245001140 LemA family; Region: LemA; cl00742
688245001141 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
688245001142 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161
688245001143 Cytochrome c; Region: Cytochrom_C; cl11414
688245001144 Cytochrome c; Region: Cytochrom_C; cl11414
688245001145 NodT family; Region: outer_NodT; TIGR01845
688245001146 Outer membrane efflux protein; Region: OEP; pfam02321
688245001147 Outer membrane efflux protein; Region: OEP; pfam02321
688245001148 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
688245001149 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
688245001150 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
688245001151 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
688245001152 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
688245001153 elongation factor Tu; Reviewed; Region: PRK12735
688245001154 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors...; Region: EF_Tu; cd01884
688245001155 G1 box; other site
688245001156 GEF interaction site; other site
688245001157 GTP/Mg2+ binding site; other site
688245001158 Switch I region; other site
688245001159 G2 box; other site
688245001160 G3 box; other site
688245001161 Switch II region; other site
688245001162 G4 box; other site
688245001163 G5 box; other site
688245001164 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
688245001165 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707
688245001166 Antibiotic Binding Site; other site
688245001167 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
688245001168 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
688245001169 Transcription termination factor nusG; Region: NusG; cl02766
688245001170 50S ribosomal protein L11; Validated; Region: rplK; PRK00140
688245001171 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
688245001172 23S rRNA interface; other site
688245001173 L7/L12 interface; other site
688245001174 putative thiostrepton binding site; other site
688245001175 L25 interface; other site
688245001176 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403
688245001177 mRNA/rRNA interface; other site
688245001178 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797
688245001179 23S rRNA interface; other site
688245001180 Interface with L7/L12 ribosomal proteins; other site
688245001181 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
688245001182 peripheral dimer interface; other site
688245001183 core dimer interface; other site
688245001184 L10 interface; other site
688245001185 L11 interface; other site
688245001186 putative EF-Tu interaction site; other site
688245001187 putative EF-G interaction site; other site
688245001188 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
688245001189 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK01497
688245001190 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
688245001191 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
688245001192 RPB11 interaction site; other site
688245001193 RPB12 interaction site; other site
688245001194 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
688245001195 RPB3 interaction site; other site
688245001196 RPB1 interaction site; other site
688245001197 RPB11 interaction site; other site
688245001198 RPB10 interaction site; other site
688245001199 DNA-directed RNA polymerase, gamma subunit; Region: rpoC1_cyan; TIGR02387
688245001200 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
688245001201 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
688245001202 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
688245001203 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK02597
688245001204 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
688245001205 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
688245001206 Rpb1 - Rpb6 interaction site; other site
688245001207 DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603
688245001208 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
688245001209 DNA binding site
688245001210 Rpb1 (beta') - Rpb2 (beta) interaction site; other site
688245001211 16S rRNA methyltransferase B; Provisional; Region: PRK10901
688245001212 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223
688245001213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
688245001214 S-adenosylmethionine binding site; other site
688245001215 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
688245001216 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
688245001217 dimerization interface; other site
688245001218 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
688245001219 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans...; Region: HisKA; cd00082
688245001220 dimer interface; other site
688245001221 phosphorylation site
688245001222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245001223 ATP binding site; other site
688245001224 Mg2+ binding site; other site
688245001225 G-X-G motif; other site
688245001226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245001227 active site
688245001228 phosphorylation site
688245001229 intermolecular recognition site; other site
688245001230 dimerization interface; other site
688245001231 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
688245001232 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
688245001233 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
688245001234 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
688245001235 UvrD/REP helicase; Region: UvrD-helicase; cl14126
688245001236 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
688245001237 Putative ATPase (DUF699); Region: DUF699; pfam05127
688245001238 UvrD/REP helicase; Region: UvrD-helicase; cl14126
688245001239 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
688245001240 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
688245001241 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
688245001242 C-terminal domain interface; other site
688245001243 GSH binding site (G-site); other site
688245001244 dimer interface; other site
688245001245 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cd00299
688245001246 N-terminal domain interface; other site
688245001247 dimer interface; other site
688245001248 substrate binding pocket (H-site); other site
688245001249 Protein of unknown function (DUF461); Region: DUF461; cl01071
688245001250 FIST N domain; Region: FIST; pfam08495
688245001251 FIST C domain; Region: FIST_C; pfam10442
688245001252 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
688245001253 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
688245001254 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
688245001255 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
688245001256 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245001257 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
688245001258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245001259 putative substrate translocation pore; other site
688245001260 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
688245001261 putative acyl-acceptor binding pocket; other site
688245001262 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249
688245001263 Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916
688245001264 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
688245001265 MASE1; Region: MASE1; cl01367
688245001266 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245001267 metal-binding site
688245001268 active site
688245001269 I-site; other site
688245001270 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409
688245001271 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
688245001272 Ligand Binding Site; other site
688245001273 Transcriptional regulators [Transcription]; Region: MarR; COG1846
688245001274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245001275 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255
688245001276 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245001277 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
688245001278 active site
688245001279 FMN binding site; other site
688245001280 substrate binding site; other site
688245001281 homotetramer interface; other site
688245001282 catalytic residue; other site
688245001283 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245001284 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
688245001285 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
688245001286 enoyl-CoA hydratase; Provisional; Region: PRK06142
688245001287 substrate binding site; other site
688245001288 oxyanion hole (OAH) forming residues; other site
688245001289 trimer interface; other site
688245001290 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
688245001291 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245001292 active site
688245001293 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
688245001294 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245001295 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586
688245001296 active site
688245001297 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
688245001298 homotrimer interaction site; other site
688245001299 putative active site; other site
688245001300 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
688245001301 active site
688245001302 catalytic triad; other site
688245001303 oxyanion hole; other site
688245001304 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among Gram...; Region: OMPLA; cd00541
688245001305 substrate binding site; other site
688245001306 dimerization interface; other site
688245001307 active site
688245001308 calcium binding site; other site
688245001309 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
688245001310 UvrD/REP helicase; Region: UvrD-helicase; cl14126
688245001311 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
688245001312 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882
688245001313 G1 box; other site
688245001314 GTP/Mg2+ binding site; other site
688245001315 G2 box; other site
688245001316 Switch I region; other site
688245001317 G3 box; other site
688245001318 Switch II region; other site
688245001319 Membrane transport protein; Region: Mem_trans; cl09117
688245001320 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cd00411
688245001321 tetramer interface; other site
688245001322 active site/substrate binding site
688245001323 primosome assembly protein PriA; Validated; Region: PRK05580
688245001324 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
688245001325 ATP binding site; other site
688245001326 putative Mg++ binding site; other site
688245001327 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl12029
688245001328 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
688245001329 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717
688245001330 substrate binding site; other site
688245001331 active site
688245001332 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl00357
688245001333 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
688245001334 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233
688245001335 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515
688245001336 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
688245001337 DsbD alpha interface; other site
688245001338 catalytic residues; other site
688245001339 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
688245001340 MatE; Region: MatE; pfam01554
688245001341 MatE; Region: MatE; pfam01554
688245001342 Creatinine amidohydrolase; Region: Creatininase; cl00618
688245001343 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245001344 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
688245001345 catalytic core; other site
688245001346 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245001347 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
688245001348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245001349 dimer interface; other site
688245001350 conserved gate region; other site
688245001351 putative PBP binding loops; other site
688245001352 ABC-ATPase subunit interface; other site
688245001353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245001354 dimer interface; other site
688245001355 conserved gate region; other site
688245001356 putative PBP binding loops; other site
688245001357 ABC-ATPase subunit interface; other site
688245001358 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
688245001359 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245001360 Walker A/P-loop; other site
688245001361 ATP binding site; other site
688245001362 Q-loop/lid; other site
688245001363 ABC transporter signature motif; other site
688245001364 Walker B; other site
688245001365 D-loop; other site
688245001366 H-loop/switch region; other site
688245001367 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
688245001368 hypothetical protein; Provisional; Region: PRK10281
688245001369 hypothetical protein; Provisional; Region: PRK10281
688245001370 aspartate aminotransferase; Provisional; Region: PRK06108
688245001371 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688245001372 pyridoxal 5'-phosphate binding site; other site
688245001373 homodimer interface; other site
688245001374 catalytic residue; other site
688245001375 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
688245001376 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245001377 DNA binding site
688245001378 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688245001379 pyridoxal 5'-phosphate binding site; other site
688245001380 homodimer interface; other site
688245001381 catalytic residue; other site
688245001382 YdjC-like protein; Region: YdjC; cl01344
688245001383 GtrA-like protein; Region: GtrA; cl00971
688245001384 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
688245001385 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
688245001386 Ligand binding site; other site
688245001387 Putative Catalytic site; other site
688245001388 DXD motif; other site
688245001389 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
688245001390 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052
688245001391 SAF domain; Region: SAF; cl00555
688245001392 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
688245001393 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl09471
688245001394 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
688245001395 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429
688245001396 Flagellar hook capping protein; Region: FlgD; cl04347
688245001397 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
688245001398 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
688245001399 Flagellar basal body protein FlaE; Region: FlaE; pfam07559
688245001400 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
688245001401 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429
688245001402 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
688245001403 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
688245001404 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
688245001405 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
688245001406 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
688245001407 Flagellar L-ring protein; Region: FlgH; cl00905
688245001408 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
688245001409 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
688245001410 flagellar rod assembly protein/muramidase FlgJ; Region: flagell_FlgJ; TIGR02541
688245001411 Rod binding protein; Region: Rod-binding; cl01626
688245001412 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743
688245001413 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945
688245001414 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429
688245001415 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870
688245001416 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
688245001417 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
688245001418 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
688245001419 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
688245001420 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017
688245001421 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; pfam01312
688245001422 FHIPEP family; Region: FHIPEP; cl07980
688245001423 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789
688245001424 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995
688245001425 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
688245001426 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
688245001427 Sigma-70 region 3; Region: Sigma70_r3; pfam04539
688245001428 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
688245001429 DNA binding residues
688245001430 Flagellar protein FliT; Region: FliT; cl05125
688245001431 Flagellar protein FliS; Region: FliS; cl00654
688245001432 flagellar capping protein; Reviewed; Region: fliD; PRK08032
688245001433 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
688245001434 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
688245001435 flagellin; Reviewed; Region: PRK08869
688245001436 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
688245001437 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
688245001438 flagellin; Reviewed; Region: PRK08869
688245001439 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
688245001440 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
688245001441 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
688245001442 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
688245001443 flagellar motor protein MotB; Validated; Region: motB; PRK09041
688245001444 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
688245001445 ligand binding site; other site
688245001446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245001447 active site
688245001448 phosphorylation site
688245001449 intermolecular recognition site; other site
688245001450 dimerization interface; other site
688245001451 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
688245001452 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
688245001453 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
688245001454 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
688245001455 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
688245001456 flagellar motor switch protein G; Validated; Region: fliG; PRK05686
688245001457 FliG C-terminal domain; Region: FliG_C; pfam01706
688245001458 Flagellar assembly protein FliH; Region: FliH; pfam02108
688245001459 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
688245001460 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
688245001461 Walker A motif/ATP binding site; other site
688245001462 Walker B motif; other site
688245001463 Flagellar FliJ protein; Region: FliJ; cl09161
688245001464 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
688245001465 Flagellar basal body-associated protein FliL; Region: FliL; cl00681
688245001466 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
688245001467 Surface presentation of antigens (SPOA); Region: SpoA; cl00819
688245001468 flagellar motor switch protein; Validated; Region: fliN; PRK05698
688245001469 Surface presentation of antigens (SPOA); Region: SpoA; cl00819
688245001470 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
688245001471 FliP family; Region: FliP; cl00593
688245001472 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
688245001473 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
688245001474 response regulator; Provisional; Region: PRK09483
688245001475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245001476 active site
688245001477 phosphorylation site
688245001478 intermolecular recognition site; other site
688245001479 dimerization interface; other site
688245001480 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
688245001481 DNA binding residues
688245001482 dimerization interface; other site
688245001483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245001484 active site
688245001485 phosphorylation site
688245001486 intermolecular recognition site; other site
688245001487 dimerization interface; other site
688245001488 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
688245001489 Histidine kinase; Region: HisKA_3; pfam07730
688245001490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245001491 ATP binding site; other site
688245001492 Mg2+ binding site; other site
688245001493 G-X-G motif; other site
688245001494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245001495 active site
688245001496 phosphorylation site
688245001497 intermolecular recognition site; other site
688245001498 dimerization interface; other site
688245001499 chemotaxis protein CheA; Provisional; Region: PRK10547
688245001500 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
688245001501 putative binding surface; other site
688245001502 active site
688245001503 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
688245001504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245001505 ATP binding site; other site
688245001506 Mg2+ binding site; other site
688245001507 G-X-G motif; other site
688245001508 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
688245001509 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
688245001510 putative CheA interaction surface; other site
688245001511 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
688245001512 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
688245001513 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245001514 CheD; Region: CheD; cl00810
688245001515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245001516 chemotaxis-specific methylesterase; Provisional; Region: PRK00742
688245001517 active site
688245001518 phosphorylation site
688245001519 intermolecular recognition site; other site
688245001520 dimerization interface; other site
688245001521 CheB methylesterase; Region: CheB_methylest; pfam01339
688245001522 ABC transporter ATPase component; Reviewed; Region: PRK11147
688245001523 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245001524 Walker A/P-loop; other site
688245001525 ATP binding site; other site
688245001526 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245001527 Q-loop/lid; other site
688245001528 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
688245001529 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
688245001530 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
688245001531 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
688245001532 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
688245001533 DNA binding residues
688245001534 putative dimer interface; other site
688245001535 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
688245001536 CoenzymeA binding site; other site
688245001537 subunit interaction site; other site
688245001538 PHB binding site; other site
688245001539 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
688245001540 isovaleryl-CoA dehydrogenase; Region: PLN02519
688245001541 substrate binding site; other site
688245001542 FAD binding site; other site
688245001543 catalytic base; other site
688245001544 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
688245001545 active site clefts
688245001546 zinc binding site; other site
688245001547 dimer interface; other site
688245001548 Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; cl01891
688245001549 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
688245001550 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
688245001551 dimer interface; other site
688245001552 active site
688245001553 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
688245001554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245001555 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
688245001556 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245001557 active site
688245001558 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
688245001559 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245001560 Protein of unknown function (DUF421); Region: DUF421; cl00990
688245001561 SEC-C motif; Region: SEC-C; cl12132
688245001562 hypothetical protein; Provisional; Region: PRK04233
688245001563 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
688245001564 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192
688245001565 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
688245001566 dimer interface; other site
688245001567 phosphorylation site
688245001568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245001569 ATP binding site; other site
688245001570 Mg2+ binding site; other site
688245001571 G-X-G motif; other site
688245001572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245001573 active site
688245001574 phosphorylation site
688245001575 intermolecular recognition site; other site
688245001576 dimerization interface; other site
688245001577 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
688245001578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245001579 active site
688245001580 phosphorylation site
688245001581 intermolecular recognition site; other site
688245001582 dimerization interface; other site
688245001583 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
688245001584 DNA binding residues
688245001585 dimerization interface; other site
688245001586 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
688245001587 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
688245001588 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572
688245001589 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
688245001590 AMP-binding domain protein; Validated; Region: PRK08315
688245001591 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245001592 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
688245001593 3-methylcrotonyl-CoA carboxylase; Region: PLN02820
688245001594 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513
688245001595 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
688245001596 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245001597 enoyl-CoA hydratase; Provisional; Region: PRK06142
688245001598 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
688245001599 substrate binding site; other site
688245001600 oxyanion hole (OAH) forming residues; other site
688245001601 trimer interface; other site
688245001602 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
688245001603 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
688245001604 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
688245001605 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
688245001606 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850
688245001607 carboxyltransferase (CT) interaction site; other site
688245001608 biotinylation site; other site
688245001609 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245001610 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
688245001611 active site
688245001612 catalytic residues; other site
688245001613 metal-binding site
688245001614 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973
688245001615 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
688245001616 putative deacylase active site; other site
688245001617 Protein of unknown function (DUF1289); Region: DUF1289; cl01304
688245001618 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
688245001619 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1,2...; Region: DsbA_HCCA_Iso; cd03022
688245001620 putative catalytic residue; other site
688245001621 Phosphoesterase family; Region: Phosphoesterase; cl10627
688245001622 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
688245001623 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
688245001624 Sodium:solute symporter family; Region: SSF; cl00456
688245001625 Predicted symporter [General function prediction only]; Region: DhlC; COG4147
688245001626 Protein of unknown function, DUF485; Region: DUF485; cl01231
688245001627 alpha-ketoglutarate transporter; Provisional; Region: PRK10406
688245001628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245001629 putative substrate translocation pore; other site
688245001630 metabolite-proton symporter; Region: 2A0106; TIGR00883
688245001631 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342
688245001632 trimer interface; other site
688245001633 eyelet of channel; other site
688245001634 excinuclease ABC, A subunit; Region: uvra; TIGR00630
688245001635 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
688245001636 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
688245001637 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245001638 Walker A/P-loop; other site
688245001639 ATP binding site; other site
688245001640 Q-loop/lid; other site
688245001641 ABC transporter signature motif; other site
688245001642 Walker B; other site
688245001643 D-loop; other site
688245001644 H-loop/switch region; other site
688245001645 excinuclease ABC, A subunit; Region: uvra; TIGR00630
688245001646 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
688245001647 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
688245001648 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
688245001649 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
688245001650 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688245001651 DctM-like transporters; Region: DctM; pfam06808
688245001652 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
688245001653 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710
688245001654 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
688245001655 peptide chain release factor 3; Provisional; Region: prfC; PRK00741
688245001656 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169
688245001657 G1 box; other site
688245001658 putative GEF interaction site; other site
688245001659 GTP/Mg2+ binding site; other site
688245001660 Switch I region; other site
688245001661 G2 box; other site
688245001662 G3 box; other site
688245001663 Switch II region; other site
688245001664 G4 box; other site
688245001665 G5 box; other site
688245001666 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding...; Region: Translation_Factor_II_like; cl02787
688245001667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245001668 Major Facilitator Superfamily; Region: MFS_1; pfam07690
688245001669 putative substrate translocation pore; other site
688245001670 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; cl00903
688245001671 Potassium-transporting ATPase A subunit; Region: KdpA; pfam03814
688245001672 K+-transporting ATPase, c chain; Region: KdpC; cl00944
688245001673 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
688245001674 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
688245001675 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
688245001676 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
688245001677 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
688245001678 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
688245001679 Ligand Binding Site; other site
688245001680 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
688245001681 dimer interface; other site
688245001682 phosphorylation site
688245001683 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245001684 ATP binding site; other site
688245001685 Mg2+ binding site; other site
688245001686 G-X-G motif; other site
688245001687 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
688245001688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245001689 active site
688245001690 phosphorylation site
688245001691 intermolecular recognition site; other site
688245001692 dimerization interface; other site
688245001693 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
688245001694 DNA binding site
688245001695 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
688245001696 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado...; Region: AdoHcyase; cd00401
688245001697 oligomerization interface; other site
688245001698 active site
688245001699 NAD+ binding site; other site
688245001700 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
688245001701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245001702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245001703 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537
688245001704 FAD binding site; other site
688245001705 rare lipoprotein A; Provisional; Region: PRK10672
688245001706 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
688245001707 Protein of unknown function (DUF519); Region: DUF519; cl04492
688245001708 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
688245001709 23S rRNA interface; other site
688245001710 L3 interface; other site
688245001711 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
688245001712 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
688245001713 multidrug efflux system protein MdtE; Provisional; Region: PRK10504
688245001714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245001715 putative substrate translocation pore; other site
688245001716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245001717 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
688245001718 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799
688245001719 FAD binding domain; Region: FAD_binding_4; cl10516
688245001720 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
688245001721 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
688245001722 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315
688245001723 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
688245001724 Permease family; Region: Xan_ur_permease; cl00967
688245001725 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245001726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245001727 dimer interface; other site
688245001728 conserved gate region; other site
688245001729 putative PBP binding loops; other site
688245001730 ABC-ATPase subunit interface; other site
688245001731 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
688245001732 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293
688245001733 Walker A/P-loop; other site
688245001734 ATP binding site; other site
688245001735 Q-loop/lid; other site
688245001736 ABC transporter signature motif; other site
688245001737 Walker B; other site
688245001738 D-loop; other site
688245001739 H-loop/switch region; other site
688245001740 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
688245001741 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
688245001742 active site
688245001743 non-prolyl cis peptide bond; other site
688245001744 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217
688245001745 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
688245001746 hypothetical protein; Provisional; Region: PRK11649
688245001747 Peptidase family M23; Region: Peptidase_M23; pfam01551
688245001748 tyrosyl-tRNA synthetase; Validated; Region: PRK05912
688245001749 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
688245001750 active site
688245001751 HIGH motif; other site
688245001752 dimer interface; other site
688245001753 KMSKS motif; other site
688245001754 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
688245001755 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245001756 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
688245001757 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
688245001758 dimerization interface; other site
688245001759 substrate binding pocket; other site
688245001760 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173
688245001761 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
688245001762 Substrate binding site; other site
688245001763 Mg++ binding site; other site
688245001764 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
688245001765 active site
688245001766 substrate binding site; other site
688245001767 CoA binding site; other site
688245001768 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans...; Region: HisKA; cd00082
688245001769 dimer interface; other site
688245001770 phosphorylation site
688245001771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245001772 ATP binding site; other site
688245001773 Mg2+ binding site; other site
688245001774 G-X-G motif; other site
688245001775 MASE2 domain; Region: MASE2; pfam05230
688245001776 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245001777 metal-binding site
688245001778 active site
688245001779 I-site; other site
688245001780 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245001781 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245001782 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
688245001783 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714
688245001784 glutaminase active site; other site
688245001785 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
688245001786 dimer interface; other site
688245001787 active site
688245001788 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
688245001789 dimer interface; other site
688245001790 active site
688245001791 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688245001792 DctM-like transporters; Region: DctM; pfam06808
688245001793 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
688245001794 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710
688245001795 Transcriptional regulators [Transcription]; Region: GntR; COG1802
688245001796 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245001797 DNA binding site
688245001798 FCD domain; Region: FCD; cl11656
688245001799 Protein of unknown function (DUF969); Region: DUF969; cl01573
688245001800 Protein of unknown function (DUF979); Region: DUF979; cl01572
688245001801 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
688245001802 putative substrate binding pocket; other site
688245001803 AC domain interface; other site
688245001804 catalytic triad; other site
688245001805 AB domain interface; other site
688245001806 interchain disulfide; other site
688245001807 LamB/YcsF family; Region: LamB_YcsF; cl00664
688245001808 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
688245001809 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
688245001810 Allophanate hydrolase subunit 2; Region: AHS2; cl00865
688245001811 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
688245001812 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
688245001813 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
688245001814 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
688245001815 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
688245001816 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850
688245001817 carboxyltransferase (CT) interaction site; other site
688245001818 biotinylation site; other site
688245001819 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
688245001820 metal-binding site
688245001821 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
688245001822 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
688245001823 metal-binding site
688245001824 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
688245001825 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
688245001826 riboflavin synthase subunit alpha; Provisional; Region: PRK13020
688245001827 Lumazine binding domain; Region: Lum_binding; pfam00677
688245001828 Lumazine binding domain; Region: Lum_binding; pfam00677
688245001829 Predicted acyltransferase [General function prediction only]; Region: COG4801
688245001830 Protein of unknown function (DUF342); Region: DUF342; pfam03961
688245001831 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
688245001832 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688245001833 pyridoxal 5'-phosphate binding site; other site
688245001834 homodimer interface; other site
688245001835 catalytic residue; other site
688245001836 Protein of unknown function (DUF1338); Region: DUF1338; cl02226
688245001837 Protein of unknown function (DUF1338); Region: DUF1338; cl02226
688245001838 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245001839 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
688245001840 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
688245001841 dimerization interface; other site
688245001842 substrate binding pocket; other site
688245001843 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
688245001844 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
688245001845 substrate binding pocket; other site
688245001846 membrane-bound complex binding site; other site
688245001847 hinge residues; other site
688245001848 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816
688245001849 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
688245001850 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342
688245001851 eyelet of channel; other site
688245001852 trimer interface; other site
688245001853 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
688245001854 DNA-K related protein; Region: DUF3731; pfam12531
688245001855 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245001856 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
688245001857 Nitrate and nitrite sensing; Region: NIT; pfam08376
688245001858 ANTAR domain; Region: ANTAR; pfam03861
688245001859 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
688245001860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245001861 dimer interface; other site
688245001862 conserved gate region; other site
688245001863 putative PBP binding loops; other site
688245001864 ABC-ATPase subunit interface; other site
688245001865 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293
688245001866 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
688245001867 Walker A/P-loop; other site
688245001868 ATP binding site; other site
688245001869 Q-loop/lid; other site
688245001870 ABC transporter signature motif; other site
688245001871 Walker B; other site
688245001872 D-loop; other site
688245001873 H-loop/switch region; other site
688245001874 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
688245001875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245001876 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
688245001877 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
688245001878 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
688245001879 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
688245001880 [2Fe-2S] cluster binding site; other site
688245001881 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_Nitrate-R-NapA-like; cd02754
688245001882 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
688245001883 [4Fe-4S] binding site; other site
688245001884 molybdopterin cofactor binding site; other site
688245001885 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
688245001886 molybdopterin cofactor binding site; other site
688245001887 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
688245001888 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
688245001889 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
688245001890 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
688245001891 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
688245001892 tetramerization interface; other site
688245001893 NAD(P) binding site; other site
688245001894 catalytic residues; other site
688245001895 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245001896 N-terminal plug; other site
688245001897 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
688245001898 ligand-binding site; other site
688245001899 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998
688245001900 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245001901 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147
688245001902 putative metal binding site; other site
688245001903 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
688245001904 putative PBP binding regions; other site
688245001905 ABC-ATPase subunit interface; other site
688245001906 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
688245001907 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
688245001908 Walker A/P-loop; other site
688245001909 ATP binding site; other site
688245001910 Q-loop/lid; other site
688245001911 ABC transporter signature motif; other site
688245001912 Walker B; other site
688245001913 D-loop; other site
688245001914 H-loop/switch region; other site
688245001915 Fusaric acid resistance protein family; Region: FUSC; pfam04632
688245001916 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245001917 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
688245001918 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
688245001919 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
688245001920 putative dimerization interface; other site
688245001921 CreA protein; Region: CreA; cl01154
688245001922 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
688245001923 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245001924 N-terminal plug; other site
688245001925 ligand-binding site; other site
688245001926 cyanophycin synthetase; Provisional; Region: PRK14016
688245001927 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
688245001928 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
688245001929 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
688245001930 cyanophycin synthetase; Provisional; Region: PRK14016
688245001931 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
688245001932 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
688245001933 ABC transporter transmembrane region; Region: ABC_membrane; cl00549
688245001934 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
688245001935 Walker A/P-loop; other site
688245001936 ATP binding site; other site
688245001937 Q-loop/lid; other site
688245001938 ABC transporter signature motif; other site
688245001939 Walker B; other site
688245001940 D-loop; other site
688245001941 H-loop/switch region; other site
688245001942 Domain of unknown function (DUF1854); Region: DUF1854; pfam08909
688245001943 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading...; Region: EFh; cd00051
688245001944 Ca2+ binding site; other site
688245001945 5'-nucleotidase; Region: 5-nucleotidase; pfam06189
688245001946 Ammonium Transporter Family; Region: Ammonium_transp; cl03012
688245001947 general secretion pathway protein F; Region: GspF; TIGR02120
688245001948 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
688245001949 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
688245001950 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245001951 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
688245001952 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_N_GTT1_like; cd03046
688245001953 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
688245001954 putative C-terminal domain interface; other site
688245001955 putative GSH binding site (G-site); other site
688245001956 putative dimer interface; other site
688245001957 GST_C family, unknown subfamily 8; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_C_8; cd03207
688245001958 putative N-terminal domain interface; other site
688245001959 putative dimer interface; other site
688245001960 putative substrate binding pocket (H-site); other site
688245001961 Predicted transcriptional regulator [Transcription]; Region: COG2378
688245001962 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245001963 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
688245001964 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
688245001965 general secretory pathway protein E; Region: type_II_gspE; TIGR02533
688245001966 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
688245001967 Walker A motif; other site
688245001968 ATP binding site; other site
688245001969 Walker B motif; other site
688245001970 general secretion pathway protein D; Region: type_II_gspD; TIGR02517
688245001971 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
688245001972 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
688245001973 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
688245001974 Bacterial type II and III secretion system protein; Region: Secretin; cl02829
688245001975 General secretion pathway protein L (GspL); Region: GspL; cl11448
688245001976 General secretion pathway protein K; Region: GspK; pfam03934
688245001977 general secretion pathway protein J; Region: gspJ; TIGR01711
688245001978 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830
688245001979 general secretion pathway protein I; Region: gspI; TIGR01707
688245001980 Bacterial type II secretion system protein I/J; Region: GSPII_IJ; pfam02501
688245001981 Type II transport protein GspH; Region: GspH; pfam12019
688245001982 Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334
688245001983 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
688245001984 Cobalamin-5-phosphate synthase; Region: CobS; cl00415
688245001985 threonine dehydratase; Reviewed; Region: PRK09224
688245001986 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
688245001987 tetramer interface; other site
688245001988 pyridoxal 5'-phosphate binding site; other site
688245001989 catalytic residue; other site
688245001990 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
688245001991 putative Ile/Val binding site; other site
688245001992 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
688245001993 putative Ile/Val binding site; other site
688245001994 OsmC-like protein; Region: OsmC; cl00767
688245001995 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
688245001996 diiron binding motif; other site
688245001997 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342
688245001998 eyelet of channel; other site
688245001999 trimer interface; other site
688245002000 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342
688245002001 trimer interface; other site
688245002002 eyelet of channel; other site
688245002003 chaperonin GroEL; Reviewed; Region: groEL; PRK12849
688245002004 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
688245002005 ring oligomerisation interface; other site
688245002006 ATP/Mg binding site; other site
688245002007 stacking interactions; other site
688245002008 hinge regions; other site
688245002009 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320
688245002010 oligomerisation interface; other site
688245002011 mobile loop; other site
688245002012 roof hairpin; other site
688245002013 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
688245002014 H-NS histone family; Region: Histone_HNS; pfam00816
688245002015 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
688245002016 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00443
688245002017 Coenzyme A binding pocket; other site
688245002018 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
688245002019 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
688245002020 active site
688245002021 nucleotide binding site; other site
688245002022 HIGH motif; other site
688245002023 KMSKS motif; other site
688245002024 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447
688245002025 nudix motif; other site
688245002026 NAD synthetase; Provisional; Region: PRK13981
688245002027 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
688245002028 multimer interface; other site
688245002029 active site
688245002030 catalytic triad; other site
688245002031 protein interface 1; other site
688245002032 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553
688245002033 homodimer interface; other site
688245002034 NAD binding pocket; other site
688245002035 ATP binding pocket; other site
688245002036 Mg binding site; other site
688245002037 active-site loop
688245002038 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
688245002039 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: PncB_like; cd01401
688245002040 active site
688245002041 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
688245002042 catalytic triad; other site
688245002043 conserved cis-peptide bond; other site
688245002044 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883
688245002045 nudix motif; other site
688245002046 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447
688245002047 S-adenosylmethionine synthetase; Validated; Region: PRK05250
688245002048 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
688245002049 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
688245002050 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
688245002051 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
688245002052 putative acyl-acceptor binding pocket; other site
688245002053 lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK08734
688245002054 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
688245002055 putative acyl-acceptor binding pocket; other site
688245002056 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
688245002057 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245002058 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876
688245002059 G1 box; other site
688245002060 GTP/Mg2+ binding site; other site
688245002061 Switch I region; other site
688245002062 G2 box; other site
688245002063 G3 box; other site
688245002064 Switch II region; other site
688245002065 G4 box; other site
688245002066 G5 box; other site
688245002067 Cytochrome c; Region: Cytochrom_C; cl11414
688245002068 Cytochrome c; Region: Cytochrom_C; cl11414
688245002069 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
688245002070 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
688245002071 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
688245002072 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
688245002073 Moco binding site; other site
688245002074 metal coordination site; other site
688245002075 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043
688245002076 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
688245002077 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in...; Region: Frataxin; cl00238
688245002078 putative iron binding site; other site
688245002079 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
688245002080 Transglycosylase; Region: Transgly; cl07896
688245002081 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
688245002082 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
688245002083 Cell division protein FtsA; Region: FtsA; cl11496
688245002084 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
688245002085 Fimbrial assembly protein (PilN); Region: PilN; pfam05137
688245002086 Pilus assembly protein, PilO; Region: PilO; cl01234
688245002087 Pilus assembly protein, PilP; Region: PilP; cl01235
688245002088 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
688245002089 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
688245002090 Bacterial type II and III secretion system protein; Region: Secretin; cl02829
688245002091 shikimate kinase; Reviewed; Region: aroK; PRK00131
688245002092 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464
688245002093 ADP binding site; other site
688245002094 magnesium binding site; other site
688245002095 putative shikimate binding site; other site
688245002096 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
688245002097 active site
688245002098 dimer interface; other site
688245002099 metal-binding site
688245002100 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926
688245002101 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
688245002102 Zn2+ binding site; other site
688245002103 Mg2+ binding site; other site
688245002104 Protein of unknown function (DUF1415); Region: DUF1415; cl01301
688245002105 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
688245002106 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
688245002107 active site
688245002108 dimer interface; other site
688245002109 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
688245002110 dimer interface; other site
688245002111 active site
688245002112 Transaldolases including both TalA and TalB. The enzyme catalyses the reversible transfer of a dyhydroxyacetone moiety, derived from fructose-6-phosphate to erythrose-4-phosphate yielding sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate. The...; Region: Transaldolase_TalAB; cd00957
688245002113 active site
688245002114 dimer interface; other site
688245002115 catalytic residue; other site
688245002116 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
688245002117 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013
688245002118 putative active site; other site
688245002119 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
688245002120 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245002121 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245002122 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
688245002123 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
688245002124 dimer interface; other site
688245002125 active site
688245002126 Coenzyme A transferase; Region: CoA_trans; cl00773
688245002127 Coenzyme A transferase; Region: CoA_trans; cl00773
688245002128 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
688245002129 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245002130 Bacterial transcriptional regulator; Region: IclR; pfam01614
688245002131 Transposase IS200 like; Region: Transposase_17; cl00848
688245002132 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
688245002133 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713
688245002134 active site
688245002135 dimer interface; other site
688245002136 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
688245002137 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808
688245002138 active site
688245002139 FMN binding site; other site
688245002140 substrate binding site; other site
688245002141 3Fe-4S cluster binding site; other site
688245002142 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
688245002143 domain interface; other site
688245002144 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
688245002145 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245002146 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697
688245002147 TM1410 hypothetical-related protein; Region: DUF297; cl00997
688245002148 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061
688245002149 Predicted integral membrane protein [Function unknown]; Region: COG5616
688245002150 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_3; cd03813
688245002151 Predicted membrane protein [Function unknown]; Region: COG4267
688245002152 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
688245002153 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
688245002154 substrate binding pocket; other site
688245002155 membrane-bound complex binding site; other site
688245002156 hinge residues; other site
688245002157 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
688245002158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245002159 dimer interface; other site
688245002160 conserved gate region; other site
688245002161 putative PBP binding loops; other site
688245002162 ABC-ATPase subunit interface; other site
688245002163 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
688245002164 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
688245002165 Walker A/P-loop; other site
688245002166 ATP binding site; other site
688245002167 Q-loop/lid; other site
688245002168 ABC transporter signature motif; other site
688245002169 Walker B; other site
688245002170 D-loop; other site
688245002171 H-loop/switch region; other site
688245002172 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
688245002173 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
688245002174 Walker A/P-loop; other site
688245002175 ATP binding site; other site
688245002176 Q-loop/lid; other site
688245002177 ABC transporter signature motif; other site
688245002178 Walker B; other site
688245002179 D-loop; other site
688245002180 H-loop/switch region; other site
688245002181 Domain of unknown function DUF140; Region: DUF140; cl00510
688245002182 mce related protein; Region: MCE; pfam02470
688245002183 VacJ like lipoprotein; Region: VacJ; cl01073
688245002184 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; cl01074
688245002185 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
688245002186 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
688245002187 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263
688245002188 Walker A/P-loop; other site
688245002189 ATP binding site; other site
688245002190 Q-loop/lid; other site
688245002191 ABC transporter signature motif; other site
688245002192 Walker B; other site
688245002193 D-loop; other site
688245002194 H-loop/switch region; other site
688245002195 ABC-2 type transporter; Region: ABC2_membrane; cl11417
688245002196 BolA-like protein; Region: BolA; cl00386
688245002197 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
688245002198 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
688245002199 hinge; other site
688245002200 active site
688245002201 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245002202 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L...; Region: Histidinol_dh; cd06572
688245002203 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
688245002204 NAD binding site; other site
688245002205 dimerization interface; other site
688245002206 product binding site; other site
688245002207 substrate binding site; other site
688245002208 zinc binding site; other site
688245002209 catalytic residues; other site
688245002210 Beta-lactamase; Region: Beta-lactamase; cl01009
688245002211 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
688245002212 PIN domain; Region: PIN; cl09128
688245002213 histidinol-phosphate aminotransferase; Validated; Region: PRK00950
688245002214 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688245002215 pyridoxal 5'-phosphate binding site; other site
688245002216 homodimer interface; other site
688245002217 catalytic residue; other site
688245002218 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
688245002219 putative active site pocket; other site
688245002220 4-fold oligomerization interface; other site
688245002221 metal binding residues; metal-binding site
688245002222 3-fold/trimer interface; other site
688245002223 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
688245002224 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
688245002225 putative active site; other site
688245002226 oxyanion strand; other site
688245002227 catalytic triad; other site
688245002228 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106
688245002229 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732
688245002230 catalytic residues; other site
688245002231 Aldose 1-epimerase; Region: Aldose_epim; cl00476
688245002232 hypothetical protein; Provisional; Region: PRK09936
688245002233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5298
688245002234 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
688245002235 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
688245002236 binding surface
688245002237 TPR motif; other site
688245002238 cellulose synthase subunit BcsC; Provisional; Region: PRK11447
688245002239 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782
688245002240 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234
688245002241 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157
688245002242 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234
688245002243 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
688245002244 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
688245002245 active site
688245002246 homodimer interface; other site
688245002247 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802
688245002248 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
688245002249 active site
688245002250 substrate binding site; other site
688245002251 metal-binding site
688245002252 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731
688245002253 Histidine biosynthesis protein; Region: His_biosynth; pfam00977
688245002254 substrate binding site; other site
688245002255 glutamase interaction surface; other site
688245002256 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
688245002257 Phosphoribosyl-ATP pyrophosphohydrolase; Region: PRA-PH; cl00345
688245002258 Predicted membrane protein [Function unknown]; Region: COG3671
688245002259 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
688245002260 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
688245002261 active site
688245002262 nucleophile elbow; other site
688245002263 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
688245002264 nucleotide binding site/active site; other site
688245002265 HIT family signature motif; other site
688245002266 catalytic residue; other site
688245002267 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
688245002268 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
688245002269 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
688245002270 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
688245002271 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149
688245002272 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
688245002273 protein binding site; other site
688245002274 metabolite-proton symporter; Region: 2A0106; TIGR00883
688245002275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245002276 putative substrate translocation pore; other site
688245002277 Transcriptional regulators [Transcription]; Region: FadR; COG2186
688245002278 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245002279 DNA binding site
688245002280 FCD domain; Region: FCD; cl11656
688245002281 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
688245002282 enoyl-CoA hydratase; Provisional; Region: PRK06142
688245002283 substrate binding site; other site
688245002284 oxyanion hole (OAH) forming residues; other site
688245002285 trimer interface; other site
688245002286 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245002287 malonyl-CoA synthase; Validated; Region: PRK07514
688245002288 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245002289 Uncharacterized conserved protein [Function unknown]; Region: COG0327
688245002290 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309
688245002291 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
688245002292 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
688245002293 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
688245002294 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
688245002295 [2Fe-2S] cluster binding site; other site
688245002296 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
688245002297 Qi binding site; other site
688245002298 intrachain domain interface; other site
688245002299 interchain domain interface; other site
688245002300 cytochrome b; Provisional; Region: CYTB; MTH00145
688245002301 heme bH binding site; other site
688245002302 heme bL binding site; other site
688245002303 Qo binding site; other site
688245002304 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: cytochrome_b_C; cl00193
688245002305 interchain domain interface; other site
688245002306 intrachain domain interface; other site
688245002307 Qi binding site; other site
688245002308 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: cytochrome_b_C; cl00193
688245002309 Qo binding site; other site
688245002310 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
688245002311 stringent starvation protein A; Provisional; Region: sspA; PRK09481
688245002312 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
688245002313 C-terminal domain interface; other site
688245002314 putative GSH binding site (G-site); other site
688245002315 dimer interface; other site
688245002316 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_C_SspA; cd03186
688245002317 dimer interface; other site
688245002318 N-terminal domain interface; other site
688245002319 Stringent starvation protein B; Region: SspB; cl01120
688245002320 SecA DEAD-like domain; Region: SecA_DEAD; pfam07517
688245002321 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
688245002322 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899
688245002323 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516
688245002324 hypothetical protein; Provisional; Region: PRK10396
688245002325 SEC-C motif; Region: SEC-C; cl12132
688245002326 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152
688245002327 heterotetramer interface; other site
688245002328 active site pocket
688245002329 cleavage site
688245002330 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
688245002331 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245002332 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
688245002333 active site
688245002334 8-oxo-dGMP binding site; other site
688245002335 nudix motif; other site
688245002336 metal-binding site
688245002337 Domain of unknown function (DUF329); Region: DUF329; cl01144
688245002338 Protein of unknown function (DUF1342); Region: DUF1342; cl01892
688245002339 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
688245002340 CoA-binding site; other site
688245002341 ATP-binding; other site
688245002342 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
688245002343 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
688245002344 Type IV leader peptidase family; Region: Peptidase_A24; cl02077
688245002345 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
688245002346 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
688245002347 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
688245002348 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
688245002349 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157
688245002350 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
688245002351 Walker A motif; other site
688245002352 ATP binding site; other site
688245002353 Walker B motif; other site
688245002354 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
688245002355 substrate binding pocket; other site
688245002356 chain length determination region; other site
688245002357 substrate-Mg2+ binding site; other site
688245002358 catalytic residues; other site
688245002359 aspartate-rich region 1; other site
688245002360 active site lid residues
688245002361 aspartate-rich region 2; other site
688245002362 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
688245002363 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
688245002364 GTPase ObgE; Reviewed; Region: obgE; PRK12299
688245002365 GTP1/OBG; Region: GTP1_OBG; pfam01018
688245002366 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898
688245002367 G1 box; other site
688245002368 GTP/Mg2+ binding site; other site
688245002369 Switch I region; other site
688245002370 G2 box; other site
688245002371 G3 box; other site
688245002372 Switch II region; other site
688245002373 G4 box; other site
688245002374 G5 box; other site
688245002375 gamma-glutamyl kinase; Provisional; Region: PRK05429
688245002376 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
688245002377 nucleotide binding site; other site
688245002378 homotetrameric interface; other site
688245002379 putative phosphate binding site; other site
688245002380 putative allosteric binding site; other site
688245002381 PUA domain; Region: PUA; cl00607
688245002382 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where...; Region: Ap4A_hydrolase_plant_like; cd03671
688245002383 putative active site; other site
688245002384 Ap4A binding site; other site
688245002385 nudix motif; other site
688245002386 putative metal binding site; other site
688245002387 prolyl-tRNA synthetase; Provisional; Region: PRK09194
688245002388 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779
688245002389 dimer interface; other site
688245002390 motif 1; other site
688245002391 active site
688245002392 motif 2; other site
688245002393 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334
688245002394 putative deacylase active site; other site
688245002395 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
688245002396 active site
688245002397 motif 3; other site
688245002398 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861
688245002399 anticodon binding site; other site
688245002400 murein transglycosylase C; Provisional; Region: mltC; PRK11671
688245002401 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254
688245002402 N-acetyl-D-glucosamine binding site; other site
688245002403 catalytic residue; other site
688245002404 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
688245002405 Domain of unknown function DUF21; Region: DUF21; pfam01595
688245002406 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
688245002407 Transporter associated domain; Region: CorC_HlyC; pfam03471
688245002408 RNase H (RNase HI) is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a not sequence-specific manner. One of the important functions of RNase H is to remove Okazaki fragments during DNA replication. RNase H knockout mice lack...; Region: RnaseH; cd06222
688245002409 RNA/DNA hybrid binding site; other site
688245002410 active site
688245002411 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
688245002412 putative GSH binding site; other site
688245002413 catalytic residues; other site
688245002414 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
688245002415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
688245002416 S-adenosylmethionine binding site; other site
688245002417 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
688245002418 peptide chain release factor 1; Validated; Region: prfA; PRK00591
688245002419 RF-1 domain; Region: RF-1; cl02875
688245002420 RF-1 domain; Region: RF-1; cl02875
688245002421 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
688245002422 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
688245002423 tRNA; other site
688245002424 putative tRNA binding site; other site
688245002425 putative NADP binding site; other site
688245002426 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745
688245002427 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
688245002428 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245002429 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245002430 dimerization interface; other site
688245002431 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245002432 N-formylglutamate amidohydrolase; Region: FGase; cl01522
688245002433 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
688245002434 Sel1 repeat; Region: Sel1; cl02723
688245002435 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
688245002436 Sel1 repeat; Region: Sel1; cl02723
688245002437 Sel1 repeat; Region: Sel1; cl02723
688245002438 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
688245002439 Sel1 repeat; Region: Sel1; cl02723
688245002440 Sel1 repeat; Region: Sel1; cl02723
688245002441 Sel1 repeat; Region: Sel1; cl02723
688245002442 Sel1 repeat; Region: Sel1; cl02723
688245002443 Sel1 repeat; Region: Sel1; cl02723
688245002444 Sel1 repeat; Region: Sel1; cl02723
688245002445 Sel1 repeat; Region: Sel1; cl02723
688245002446 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245002447 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
688245002448 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
688245002449 putative active site; other site
688245002450 catalytic site; other site
688245002451 putative metal binding site; other site
688245002452 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
688245002453 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301
688245002454 Walker A/P-loop; other site
688245002455 ATP binding site; other site
688245002456 Q-loop/lid; other site
688245002457 ABC transporter signature motif; other site
688245002458 Walker B; other site
688245002459 D-loop; other site
688245002460 H-loop/switch region; other site
688245002461 TOBE domain; Region: TOBE_2; cl01440
688245002462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245002463 dimer interface; other site
688245002464 conserved gate region; other site
688245002465 putative PBP binding loops; other site
688245002466 ABC-ATPase subunit interface; other site
688245002467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245002468 dimer interface; other site
688245002469 conserved gate region; other site
688245002470 ABC-ATPase subunit interface; other site
688245002471 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245002472 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
688245002473 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
688245002474 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
688245002475 FAD binding domain; Region: FAD_binding_4; cl10516
688245002476 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
688245002477 Heterodisulfide reductase, subunit C [Energy production and conversion]; Region: HdrC; COG1150
688245002478 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
688245002479 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880
688245002480 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228
688245002481 nucleotide binding site/active site; other site
688245002482 HIT family signature motif; other site
688245002483 catalytic residue; other site
688245002484 Protein of unknown function (DUF971); Region: DUF971; cl01414
688245002485 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
688245002486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
688245002487 S-adenosylmethionine binding site; other site
688245002488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245002489 Tim44-like domain; Region: Tim44; cl09208
688245002490 SCP-2 sterol transfer family; Region: SCP2; cl01225
688245002491 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
688245002492 Protein Kinases, catalytic domain; Region: PKc_like; cl09925
688245002493 Sodium:solute symporter family; Region: SSF; cl00456
688245002494 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
688245002495 Protein of unknown function (DUF502); Region: DUF502; cl01107
688245002496 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
688245002497 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
688245002498 dimer interface; other site
688245002499 anticodon binding site; other site
688245002500 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
688245002501 homodimer interface; other site
688245002502 motif 1; other site
688245002503 active site
688245002504 motif 2; other site
688245002505 GAD domain; Region: GAD; pfam02938
688245002506 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
688245002507 motif 3; other site
688245002508 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447
688245002509 nudix motif; other site
688245002510 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; cl00490
688245002511 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263
688245002512 active site
688245002513 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
688245002514 EamA-like transporter family; Region: EamA; cl01037
688245002515 LysE type translocator; Region: LysE; cl00565
688245002516 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
688245002517 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
688245002518 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
688245002519 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
688245002520 Walker A/P-loop; other site
688245002521 ATP binding site; other site
688245002522 Q-loop/lid; other site
688245002523 ABC transporter signature motif; other site
688245002524 Walker B; other site
688245002525 D-loop; other site
688245002526 H-loop/switch region; other site
688245002527 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
688245002528 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
688245002529 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
688245002530 Walker A/P-loop; other site
688245002531 ATP binding site; other site
688245002532 Q-loop/lid; other site
688245002533 ABC transporter signature motif; other site
688245002534 Walker B; other site
688245002535 D-loop; other site
688245002536 H-loop/switch region; other site
688245002537 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
688245002538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245002539 dimer interface; other site
688245002540 conserved gate region; other site
688245002541 putative PBP binding loops; other site
688245002542 ABC-ATPase subunit interface; other site
688245002543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245002544 dimer interface; other site
688245002545 conserved gate region; other site
688245002546 putative PBP binding loops; other site
688245002547 ABC-ATPase subunit interface; other site
688245002548 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143
688245002549 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
688245002550 putative active site; other site
688245002551 catalytic residue; other site
688245002552 Ribosomal_L25_TL5_CTC: Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain. L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC, which each contain two domains. CTC is a known stress protein, and proteins of this...; Region: Ribosomal_L25_TL5_CTC; cd00495
688245002553 5S rRNA interface; other site
688245002554 CTC domain interface; other site
688245002555 L16 interface; other site
688245002556 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462
688245002557 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
688245002558 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
688245002559 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256
688245002560 Outer membrane lipoprotein LolB; Region: LolB; pfam03550
688245002561 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
688245002562 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
688245002563 binding surface
688245002564 TPR motif; other site
688245002565 formamidopyrimidine-DNA glycosylase; Validated; Region: PRK01103
688245002566 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119
688245002567 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
688245002568 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
688245002569 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras; Region: Ras_like_GTPase; cl10444
688245002570 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
688245002571 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
688245002572 minor groove reading motif; other site
688245002573 helix-hairpin-helix signature motif; other site
688245002574 substrate binding pocket; other site
688245002575 active site
688245002576 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
688245002577 DNA binding and oxoG recognition site
688245002578 Inner membrane protein CreD; Region: CreD; cl01844
688245002579 sensory histidine kinase CreC; Provisional; Region: PRK11100
688245002580 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
688245002581 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080
688245002582 Domain of unknown function DUF37; Region: DUF37; cl00506
688245002583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245002584 ATP binding site; other site
688245002585 Mg2+ binding site; other site
688245002586 G-X-G motif; other site
688245002587 DNA-binding response regulator CreB; Provisional; Region: PRK11083
688245002588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245002589 active site
688245002590 phosphorylation site
688245002591 intermolecular recognition site; other site
688245002592 dimerization interface; other site
688245002593 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
688245002594 DNA binding site
688245002595 P-loop ATPase protein family; Region: ATP_bind_2; cl10035
688245002596 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
688245002597 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241
688245002598 Walker A/P-loop; other site
688245002599 ATP binding site; other site
688245002600 Q-loop/lid; other site
688245002601 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241
688245002602 ABC transporter signature motif; other site
688245002603 Walker B; other site
688245002604 D-loop; other site
688245002605 H-loop/switch region; other site
688245002606 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
688245002607 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
688245002608 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245002609 HrcA protein C terminal domain; Region: HrcA; pfam01628
688245002610 CHASE2 domain; Region: CHASE2; cl01732
688245002611 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
688245002612 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080
688245002613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245002614 ATP binding site; other site
688245002615 Mg2+ binding site; other site
688245002616 G-X-G motif; other site
688245002617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254
688245002618 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
688245002619 FecR protein; Region: FecR; pfam04773
688245002620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245002621 active site
688245002622 phosphorylation site
688245002623 intermolecular recognition site; other site
688245002624 dimerization interface; other site
688245002625 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
688245002626 DNA binding site
688245002627 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284
688245002628 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
688245002629 active site
688245002630 HIGH motif; other site
688245002631 dimer interface; other site
688245002632 KMSKS motif; other site
688245002633 Domain of unknown function (DUF1508); Region: DUF1508; cl01356
688245002634 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
688245002635 active site
688245002636 putative substrate binding region; other site
688245002637 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
688245002638 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
688245002639 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144
688245002640 yrdC domain; Region: Sua5_yciO_yrdC; cl00305
688245002641 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
688245002642 DNA polymerase alpha chain like domain; Region: POLIIIAc; cl02625
688245002643 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956
688245002644 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
688245002645 dimerization interface; other site
688245002646 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
688245002647 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144
688245002648 ssDNA exonuclease RecJ; Provisional; Region: PRK11070
688245002649 DHH family; Region: DHH; pfam01368
688245002650 DHHA1 domain; Region: DHHA1; pfam02272
688245002651 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl12023
688245002652 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
688245002653 Sulfatase; Region: Sulfatase; cl10460
688245002654 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245002655 Transcriptional regulators [Transcription]; Region: MarR; COG1846
688245002656 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245002657 LolC/E family; Region: lolCE; TIGR02212
688245002658 Predicted permease; Region: FtsX; cl11418
688245002659 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
688245002660 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
688245002661 Walker A/P-loop; other site
688245002662 ATP binding site; other site
688245002663 Q-loop/lid; other site
688245002664 ABC transporter signature motif; other site
688245002665 Walker B; other site
688245002666 D-loop; other site
688245002667 H-loop/switch region; other site
688245002668 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
688245002669 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
688245002670 putative active site; other site
688245002671 heme pocket; other site
688245002672 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
688245002673 putative active site; other site
688245002674 heme pocket; other site
688245002675 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144
688245002676 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
688245002677 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449
688245002678 active site
688245002679 Uracil DNA glycosylase superfamily; Region: UDG; cl00483
688245002680 spermidine synthase; Provisional; Region: PRK04457
688245002681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245002682 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157
688245002683 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
688245002684 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
688245002685 Walker A motif; other site
688245002686 ATP binding site; other site
688245002687 Walker B motif; other site
688245002688 Tripartite tricarboxylate transporter TctB family; Region: DUF1468; pfam07331
688245002689 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
688245002690 Protein of unknown function (DUF3422); Region: DUF3422; cl02073
688245002691 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245002692 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
688245002693 EamA-like transporter family; Region: EamA; cl01037
688245002694 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
688245002695 EamA-like transporter family; Region: EamA; cl01037
688245002696 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447
688245002697 nudix motif; other site
688245002698 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
688245002699 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
688245002700 PhoU domain; Region: PhoU; pfam01895
688245002701 PhoU domain; Region: PhoU; pfam01895
688245002702 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
688245002703 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
688245002704 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
688245002705 HIGH motif; other site
688245002706 active site
688245002707 nucleotide binding site; other site
688245002708 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
688245002709 active site
688245002710 KMSKS motif; other site
688245002711 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
688245002712 tRNA binding surface; other site
688245002713 anticodon binding site; other site
688245002714 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
688245002715 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
688245002716 riboflavin kinase, C-terminal domain of the bifunctional riboflavin biosynthesis protein; Region: Flavokinase_C; cd02064
688245002717 active site
688245002718 Riboflavin kinase; Region: Flavokinase; pfam01687
688245002719 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085
688245002720 active site
688245002721 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
688245002722 nucleoside/Zn binding site; other site
688245002723 dimer interface; other site
688245002724 catalytic motif; other site
688245002725 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU)...; Region: TLP_HIUase; cd05822
688245002726 active site
688245002727 homotetramer interface; other site
688245002728 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl01000
688245002729 active site
688245002730 homotetramer interface; other site
688245002731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245002732 d-galactonate transporter; Region: 2A0114; TIGR00893
688245002733 putative substrate translocation pore; other site
688245002734 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245002735 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245002736 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245002737 dimerization interface; other site
688245002738 OHCU decarboxylase; Region: OHCU_decarbox; cl01251
688245002739 Bestrophin; Region: Bestrophin; cl01544
688245002740 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
688245002741 nucleoside/Zn binding site; other site
688245002742 dimer interface; other site
688245002743 catalytic motif; other site
688245002744 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
688245002745 Acyl-CoA dehydrogenase; Region: ACAD; cd00567
688245002746 active site
688245002747 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
688245002748 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245002749 active site
688245002750 hypothetical protein; Provisional; Region: PRK11239
688245002751 Protein of unknown function, DUF480; Region: DUF480; cl01209
688245002752 Formyl transferase; Region: Formyl_trans_N; cl00395
688245002753 phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent; Region: PurN; TIGR00639
688245002754 Protein of unknown function (DUF1653); Region: DUF1653; cl01949
688245002755 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
688245002756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245002757 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
688245002758 Di-iron ligands; other site
688245002759 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
688245002760 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245002761 DNA binding site
688245002762 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688245002763 pyridoxal 5'-phosphate binding site; other site
688245002764 homodimer interface; other site
688245002765 catalytic residue; other site
688245002766 Ribosomal protein L33; Region: Ribosomal_L33; cl00383
688245002767 Ribosomal L28 family; Region: Ribosomal_L28; cl00367
688245002768 thioredoxin reductase; Provisional; Region: PRK10262
688245002769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245002770 DNA translocase FtsK; Provisional; Region: PRK10263
688245002771 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
688245002772 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245002773 Ftsk gamma domain; Region: Ftsk_gamma; cl09645
688245002774 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
688245002775 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
688245002776 recombination factor protein RarA; Reviewed; Region: PRK13342
688245002777 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245002778 Walker A motif; other site
688245002779 ATP binding site; other site
688245002780 Walker B motif; other site
688245002781 arginine finger; other site
688245002782 MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440
688245002783 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
688245002784 TM-ABC transporter signature motif; other site
688245002785 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
688245002786 TM-ABC transporter signature motif; other site
688245002787 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
688245002788 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219
688245002789 Walker A/P-loop; other site
688245002790 ATP binding site; other site
688245002791 Q-loop/lid; other site
688245002792 ABC transporter signature motif; other site
688245002793 Walker B; other site
688245002794 D-loop; other site
688245002795 H-loop/switch region; other site
688245002796 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
688245002797 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
688245002798 Walker A/P-loop; other site
688245002799 ATP binding site; other site
688245002800 Q-loop/lid; other site
688245002801 ABC transporter signature motif; other site
688245002802 Walker B; other site
688245002803 D-loop; other site
688245002804 H-loop/switch region; other site
688245002805 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
688245002806 Phosphate transporter family; Region: PHO4; cl00396
688245002807 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245002808 metal-binding site
688245002809 active site
688245002810 I-site; other site
688245002811 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
688245002812 Ribosomal protein S16; Region: Ribosomal_S16; cl00368
688245002813 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
688245002814 RimM N-terminal domain; Region: RimM; pfam01782
688245002815 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959
688245002816 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
688245002817 Ribosomal protein L19; Region: Ribosomal_L19; cl00406
688245002818 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
688245002819 putative active site; other site
688245002820 putative CoA binding site; other site
688245002821 nudix motif; other site
688245002822 metal-binding site
688245002823 CobD/Cbib protein; Region: CobD_Cbib; cl00561
688245002824 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254
688245002825 N-acetyl-D-glucosamine binding site; other site
688245002826 catalytic residue; other site
688245002827 ribosome-associated GTPase; Reviewed; Region: PRK00098
688245002828 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854
688245002829 GTPase/OB domain interface; other site
688245002830 GTPase/Zn-binding domain interface; other site
688245002831 GTP/Mg2+ binding site; other site
688245002832 G4 box; other site
688245002833 G5 box; other site
688245002834 G1 box; other site
688245002835 Switch I region; other site
688245002836 G2 box; other site
688245002837 G3 box; other site
688245002838 Switch II region; other site
688245002839 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
688245002840 aromatic arch; other site
688245002841 DCoH dimer interaction site; other site
688245002842 DCoH /HNF-1 dimer interaction site; other site
688245002843 DCoH tetramer interaction site; other site
688245002844 substrate binding site; other site
688245002845 Peptidase family M48; Region: Peptidase_M48; cl12018
688245002846 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
688245002847 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268
688245002848 ATP binding site; other site
688245002849 Mg++ binding site; other site
688245002850 motif III; other site
688245002851 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
688245002852 nucleotide binding region; other site
688245002853 ATP-binding site; other site
688245002854 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
688245002855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245002856 putative substrate translocation pore; other site
688245002857 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
688245002858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245002859 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
688245002860 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381
688245002861 active site
688245002862 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
688245002863 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
688245002864 NodT family; Region: outer_NodT; TIGR01845
688245002865 Outer membrane efflux protein; Region: OEP; pfam02321
688245002866 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
688245002867 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404
688245002868 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
688245002869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245002870 putative substrate translocation pore; other site
688245002871 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
688245002872 UvrD/REP helicase; Region: UvrD-helicase; cl14126
688245002873 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
688245002874 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
688245002875 Phosphotransferase enzyme family; Region: APH; pfam01636
688245002876 putative active site; other site
688245002877 putative substrate binding site; other site
688245002878 ATP binding site; other site
688245002879 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
688245002880 DNA polymerase I; Provisional; Region: PRK05755
688245002881 5'-3' exonuclease; T5 type 5'-3' exonuclease domains may co-occur with DNA polymerase I (Pol I) domains, or be part of Pol I containing complexes. They digest dsDNA and ssDNA, releasing mono-,di- and tri-nucleotides, as well as oligonucleotides, and...; Region: 53EXOc; cd00008
688245002882 metal binding site I; metal-binding site
688245002883 putative ssDNA interaction site; other site
688245002884 metal binding site II; metal-binding site
688245002885 3'-5' exonuclease. The 35EXOc domain is responsible for the 3'-5' exonuclease proofreading activity of prokaryotic DNA polymerase I (pol I) and other enzymes, it catalyses the hydrolysis of unpaired or mismatched nucleotides. This domain consists of...; Region: 35EXOc; cd00007
688245002886 active site
688245002887 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
688245002888 active site
688245002889 DNA binding site
688245002890 catalytic site; other site
688245002891 AzlC protein; Region: AzlC; cl00570
688245002892 Dienelactone hydrolase family; Region: DLH; pfam01738
688245002893 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
688245002894 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
688245002895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245002896 active site
688245002897 phosphorylation site
688245002898 intermolecular recognition site; other site
688245002899 dimerization interface; other site
688245002900 LytTr DNA-binding domain; Region: LytTR; cl04498
688245002901 Histidine kinase; Region: His_kinase; pfam06580
688245002902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
688245002903 argininosuccinate lyase; Provisional; Region: PRK00855
688245002904 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
688245002905 active sites
688245002906 tetramer interface; other site
688245002907 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245002908 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
688245002909 MG2 domain; Region: A2M_N; pfam01835
688245002910 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
688245002911 Alpha-2-macroglobulin family; Region: A2M; pfam00207
688245002912 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
688245002913 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
688245002914 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245002915 Walker A/P-loop; other site
688245002916 ATP binding site; other site
688245002917 Q-loop/lid; other site
688245002918 ABC transporter signature motif; other site
688245002919 Walker B; other site
688245002920 D-loop; other site
688245002921 H-loop/switch region; other site
688245002922 TOBE domain; Region: TOBE_2; cl01440
688245002923 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245002924 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
688245002925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245002926 dimer interface; other site
688245002927 conserved gate region; other site
688245002928 putative PBP binding loops; other site
688245002929 ABC-ATPase subunit interface; other site
688245002930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245002931 putative PBP binding loops; other site
688245002932 ABC-ATPase subunit interface; other site
688245002933 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; cl00490
688245002934 Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277
688245002935 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
688245002936 Transglycosylase; Region: Transgly; cl07896
688245002937 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
688245002938 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
688245002939 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245002940 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245002941 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
688245002942 putative effector binding pocket; other site
688245002943 dimerization interface; other site
688245002944 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
688245002945 dimer interface; other site
688245002946 FMN binding site; other site
688245002947 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
688245002948 EamA-like transporter family; Region: EamA; cl01037
688245002949 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
688245002950 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
688245002951 phosphate binding site; other site
688245002952 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421
688245002953 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245002954 DNA binding site
688245002955 FCD domain; Region: FCD; cl11656
688245002956 L-lactate permease; Region: Lactate_perm; cl00701
688245002957 L-lactate permease; Region: Lactate_perm; cl00701
688245002958 L-lactate permease; Provisional; Region: PRK10420
688245002959 L-lactate permease; Region: Lactate_perm; cl00701
688245002960 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
688245002961 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
688245002962 phosphate binding site; other site
688245002963 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
688245002964 EamA-like transporter family; Region: EamA; cl01037
688245002965 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
688245002966 Amino acid permease; Region: AA_permease; pfam00324
688245002967 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245002968 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409
688245002969 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
688245002970 Amino acid permease; Region: AA_permease; pfam00324
688245002971 DNA polymerase IV; Validated; Region: PRK02406
688245002972 DNA Polymerase IV/Kappa; Region: Pol_IV_kappa; cd03586
688245002973 active site
688245002974 DNA binding site
688245002975 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
688245002976 PAS fold; Region: PAS_3; pfam08447
688245002977 putative active site; other site
688245002978 heme pocket; other site
688245002979 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
688245002980 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144
688245002981 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
688245002982 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
688245002983 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263
688245002984 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206
688245002985 Protein of unknown function (DUF328); Region: DUF328; cl01143
688245002986 ribonuclease E; Reviewed; Region: rne; PRK10811
688245002987 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
688245002988 homodimer interface; other site
688245002989 oligonucleotide binding site; other site
688245002990 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
688245002991 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
688245002992 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
688245002993 active site
688245002994 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
688245002995 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
688245002996 motif II; other site
688245002997 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467
688245002998 iron-sulfur cluster; other site
688245002999 [2Fe-2S] cluster binding site; other site
688245003000 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
688245003001 tandem repeat interface; other site
688245003002 oligomer interface; other site
688245003003 active site residues
688245003004 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
688245003005 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
688245003006 active site
688245003007 dimer interface; other site
688245003008 Uncharacterized ACR, COG1399; Region: DUF177; cl00616
688245003009 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
688245003010 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
688245003011 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
688245003012 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
688245003013 dimer interface; other site
688245003014 active site
688245003015 CoA binding pocket; other site
688245003016 Acyl transferase domain; Region: Acyl_transf_1; cl08282
688245003017 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
688245003018 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245003019 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
688245003020 Phosphopantetheine attachment site; Region: PP-binding; cl09936
688245003021 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
688245003022 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
688245003023 dimer interface; other site
688245003024 active site
688245003025 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
688245003026 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
688245003027 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
688245003028 DNA binding residues
688245003029 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
688245003030 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
688245003031 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149
688245003032 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
688245003033 protein binding site; other site
688245003034 GTP-binding protein LepA; Provisional; Region: PRK05433
688245003035 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890
688245003036 G1 box; other site
688245003037 putative GEF interaction site; other site
688245003038 GTP/Mg2+ binding site; other site
688245003039 Switch I region; other site
688245003040 G2 box; other site
688245003041 G3 box; other site
688245003042 Switch II region; other site
688245003043 G4 box; other site
688245003044 G5 box; other site
688245003045 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699
688245003046 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
688245003047 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
688245003048 signal peptidase I; Provisional; Region: PRK10861
688245003049 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
688245003050 Catalytic site; other site
688245003051 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
688245003052 ribonuclease III; Reviewed; Region: rnc; PRK00102
688245003053 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593
688245003054 dimerization interface; other site
688245003055 active site
688245003056 metal-binding site
688245003057 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048
688245003058 dsRNA binding site; other site
688245003059 GTP-binding protein Era; Reviewed; Region: era; PRK00089
688245003060 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163
688245003061 G1 box; other site
688245003062 GTP/Mg2+ binding site; other site
688245003063 Switch I region; other site
688245003064 G2 box; other site
688245003065 Switch II region; other site
688245003066 G3 box; other site
688245003067 G4 box; other site
688245003068 G5 box; other site
688245003069 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098
688245003070 Recombination protein O N terminal; Region: RecO_N; pfam11967
688245003071 Recombination protein O C terminal; Region: RecO_C; pfam02565
688245003072 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003
688245003073 active site
688245003074 hydrophilic channel; other site
688245003075 dimerization interface; other site
688245003076 catalytic residues; other site
688245003077 active site lid
688245003078 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
688245003079 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
688245003080 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
688245003081 ABC transporter transmembrane region; Region: ABC_membrane; cl00549
688245003082 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223
688245003083 6-phosphofructokinase; Provisional; Region: PRK03202
688245003084 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204
688245003085 active site
688245003086 ADP/pyrophosphate binding site; other site
688245003087 dimerization interface; other site
688245003088 allosteric effector site; other site
688245003089 fructose-1,6-bisphosphate binding site; other site
688245003090 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
688245003091 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
688245003092 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
688245003093 Mechanosensitive ion channel; Region: MS_channel; pfam00924
688245003094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245003095 active site
688245003096 phosphorylation site
688245003097 intermolecular recognition site; other site
688245003098 dimerization interface; other site
688245003099 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245003100 metal-binding site
688245003101 active site
688245003102 I-site; other site
688245003103 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
688245003104 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322
688245003105 dimer interface; other site
688245003106 putative anticodon binding site; other site
688245003107 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
688245003108 motif 1; other site
688245003109 active site
688245003110 motif 2; other site
688245003111 motif 3; other site
688245003112 Found in ATP-dependent protease La (LON); Region: LON; cl01056
688245003113 ATP-dependent protease La (LON) domain; Region: LON; pfam02190
688245003114 YGGT family; Region: YGGT; cl00508
688245003115 YGGT family; Region: YGGT; cl00508
688245003116 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
688245003117 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513
688245003118 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
688245003119 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724
688245003120 substrate binding site; other site
688245003121 active site
688245003122 catalytic residues; other site
688245003123 heterodimer interface; other site
688245003124 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
688245003125 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
688245003126 pyridoxal 5'-phosphate binding site; other site
688245003127 catalytic residue; other site
688245003128 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405
688245003129 active site
688245003130 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
688245003131 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570
688245003132 dimerization interface 3.5A; other site
688245003133 active site
688245003134 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170
688245003135 FimV N-terminal domain; Region: FimV_core; TIGR03505
688245003136 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170
688245003137 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
688245003138 aspartate-semialdehyde dehydrogenase, gamma-proteobacterial; Region: asd_gamma; TIGR01745
688245003139 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245003140 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
688245003141 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
688245003142 isocitrate dehydrogenase; Validated; Region: PRK06451
688245003143 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577
688245003144 substrate binding site; other site
688245003145 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
688245003146 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
688245003147 substrate binding site; other site
688245003148 ligand binding site; other site
688245003149 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245003150 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245003151 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
688245003152 putative dimerization interface; other site
688245003153 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
688245003154 Sel1 repeat; Region: Sel1; cl02723
688245003155 Sel1 repeat; Region: Sel1; cl02723
688245003156 Sel1 repeat; Region: Sel1; cl02723
688245003157 Sel1 repeat; Region: Sel1; cl02723
688245003158 Sel1 repeat; Region: Sel1; cl02723
688245003159 chaperone protein DnaJ; Provisional; Region: PRK10767
688245003160 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257
688245003161 DnaJ C terminal region; Region: DnaJ_C; pfam01556
688245003162 DnaJ C terminal region; Region: DnaJ_C; pfam01556
688245003163 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
688245003164 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446
688245003165 dimer interface; other site
688245003166 hsp70 (ATPase domain) interactions; other site
688245003167 Ribosomal protein S6; Region: Ribosomal_S6; cl00414
688245003168 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
688245003169 Ribosomal protein S18; Region: Ribosomal_S18; cl00373
688245003170 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
688245003171 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
688245003172 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
688245003173 replicative DNA helicase; Region: DnaB; TIGR00665
688245003174 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
688245003175 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
688245003176 Walker A motif; other site
688245003177 ATP binding site; other site
688245003178 Walker B motif; other site
688245003179 DNA binding loops
688245003180 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875
688245003181 PIN domain; Region: PIN; cl09128
688245003182 PhoH-like protein; Region: PhoH; cl12134
688245003183 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017
688245003184 catalytic triad; other site
688245003185 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome...; Region: Xcc1710_like; cd05560
688245003186 alanine aminotransferase; Provisional; Region: PTZ00377
688245003187 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688245003188 pyridoxal 5'-phosphate binding site; other site
688245003189 homodimer interface; other site
688245003190 catalytic residue; other site
688245003191 homoserine dehydrogenase; Provisional; Region: PRK06349
688245003192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245003193 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
688245003194 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
688245003195 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
688245003196 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants...; Region: Thr-synth_2; cd01560
688245003197 pyridoxal 5'-phosphate binding site; other site
688245003198 catalytic residue; other site
688245003199 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa...; Region: MobB; cd03116
688245003200 Walker A motif; other site
688245003201 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
688245003202 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
688245003203 dimer interface; other site
688245003204 putative functional site; other site
688245003205 putative MPT binding site; other site
688245003206 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
688245003207 MoaE interaction surface; other site
688245003208 MoeB interaction surface; other site
688245003209 thiocarboxylated glycine; other site
688245003210 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688245003211 Recombinase; Region: Recombinase; pfam07508
688245003212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245003213 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
688245003214 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
688245003215 MoaE homodimer interface; other site
688245003216 MoaD interaction; other site
688245003217 active site residues
688245003218 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
688245003219 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
688245003220 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
688245003221 Clp amino terminal domain; Region: Clp_N; pfam02861
688245003222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245003223 Walker A motif; other site
688245003224 ATP binding site; other site
688245003225 Walker B motif; other site
688245003226 arginine finger; other site
688245003227 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245003228 Walker A motif; other site
688245003229 ATP binding site; other site
688245003230 Walker B motif; other site
688245003231 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
688245003232 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
688245003233 NAD(P) binding site; other site
688245003234 catalytic residues; other site
688245003235 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
688245003236 Coenzyme A binding pocket; other site
688245003237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
688245003238 S-adenosylmethionine binding site; other site
688245003239 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
688245003240 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801
688245003241 FMN binding site; other site
688245003242 active site
688245003243 catalytic residues; other site
688245003244 substrate binding site; other site
688245003245 Phospholipase D. Active site motifs; The PLD superfamily includes enzymes involved in signal transduction, lipid biosynthesis, endonucleases and open reading frames in pathogenic viruses and bacteria. PLD hydrolyzes the terminal phosphodiester bond of...; Region: PLDc; cd00138
688245003246 active site
688245003247 signature motif; other site
688245003248 Phospholipase D. Active site motifs; The PLD superfamily includes enzymes involved in signal transduction, lipid biosynthesis, endonucleases and open reading frames in pathogenic viruses and bacteria. PLD hydrolyzes the terminal phosphodiester bond of...; Region: PLDc; cd00138
688245003249 active site
688245003250 signature motif; other site
688245003251 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
688245003252 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
688245003253 catalytic motif; other site
688245003254 Zn binding site; other site
688245003255 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161
688245003256 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
688245003257 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830
688245003258 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
688245003259 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
688245003260 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
688245003261 Type II transport protein GspH; Region: GspH; pfam12019
688245003262 Type II transport protein GspH; Region: GspH; pfam12019
688245003263 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353
688245003264 16S/18S rRNA binding site; other site
688245003265 S13e-L30e interaction site; other site
688245003266 25S rRNA binding site; other site
688245003267 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
688245003268 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
688245003269 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
688245003270 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
688245003271 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
688245003272 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
688245003273 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
688245003274 putative nucleic acid binding region; other site
688245003275 G-X-X-G motif; other site
688245003276 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472
688245003277 RNA binding site; other site
688245003278 domain interface; other site
688245003279 potential frameshift: common BLAST hit: gi|160900615|ref|YP_001566197.1| PIG3 family NAD(P)H quinone oxidoreductase
688245003280 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
688245003281 NAD(P) binding site; other site
688245003282 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
688245003283 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
688245003284 substrate binding site; other site
688245003285 dimer interface; other site
688245003286 catalytic triad; other site
688245003287 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
688245003288 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419
688245003289 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539
688245003290 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417
688245003291 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958
688245003292 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064
688245003293 putative dimer interface; other site
688245003294 [2Fe-2S] cluster binding site; other site
688245003295 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
688245003296 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
688245003297 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl11430
688245003298 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
688245003299 NADH dehydrogenase subunit G; Validated; Region: PRK09129
688245003300 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
688245003301 catalytic loop; other site
688245003302 iron binding site; other site
688245003303 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
688245003304 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions...; Region: MopB_NDH-1_NuoG2; cd02772
688245003305 NADH dehydrogenase; Region: NADHdh; cl00469
688245003306 NADH dehydrogenase subunit I; Provisional; Region: PRK05888
688245003307 4Fe-4S binding domain; Region: Fer4; pfam00037
688245003308 4Fe-4S binding domain; Region: Fer4; pfam00037
688245003309 NADH dehydrogenase subunit J; Provisional; Region: PRK06638
688245003310 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676
688245003311 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
688245003312 NADH dehydrogenase subunit L; Reviewed; Region: PRK06590
688245003313 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
688245003314 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
688245003315 NADH dehydrogenase subunit M; Reviewed; Region: PRK05846
688245003316 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
688245003317 NADH dehydrogenase subunit N; Provisional; Region: PRK05777
688245003318 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
688245003319 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993
688245003320 Protein of unknown function (DUF1178); Region: DUF1178; cl02196
688245003321 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
688245003322 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
688245003323 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
688245003324 DNA binding residues
688245003325 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
688245003326 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
688245003327 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
688245003328 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219
688245003329 Walker A/P-loop; other site
688245003330 ATP binding site; other site
688245003331 Q-loop/lid; other site
688245003332 ABC transporter signature motif; other site
688245003333 Walker B; other site
688245003334 D-loop; other site
688245003335 H-loop/switch region; other site
688245003336 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
688245003337 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
688245003338 Walker A/P-loop; other site
688245003339 ATP binding site; other site
688245003340 Q-loop/lid; other site
688245003341 ABC transporter signature motif; other site
688245003342 Walker B; other site
688245003343 D-loop; other site
688245003344 H-loop/switch region; other site
688245003345 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
688245003346 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
688245003347 putative ligand binding site; other site
688245003348 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
688245003349 TM-ABC transporter signature motif; other site
688245003350 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
688245003351 TM-ABC transporter signature motif; other site
688245003352 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
688245003353 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493
688245003354 Trp docking motif; other site
688245003355 active site
688245003356 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493
688245003357 Trp docking motif; other site
688245003358 active site
688245003359 'Velcro' closure; other site
688245003360 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
688245003361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
688245003362 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
688245003363 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
688245003364 Predicted permease; Region: FtsX; cl11418
688245003365 Predicted permease; Region: FtsX; cl11418
688245003366 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
688245003367 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
688245003368 Walker A/P-loop; other site
688245003369 ATP binding site; other site
688245003370 Q-loop/lid; other site
688245003371 ABC transporter signature motif; other site
688245003372 Walker B; other site
688245003373 D-loop; other site
688245003374 H-loop/switch region; other site
688245003375 IPP transferase; Region: IPPT; cl00403
688245003376 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
688245003377 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
688245003378 Sulfatase; Region: Sulfatase; cl10460
688245003379 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245003380 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
688245003381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245003382 putative substrate translocation pore; other site
688245003383 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245003384 Esterase/lipase [General function prediction only]; Region: COG1647
688245003385 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245003386 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
688245003387 substrate binding site; other site
688245003388 hypothetical protein; Provisional; Region: PRK10318
688245003389 Cupin domain; Region: Cupin_2; cl09118
688245003390 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245003391 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
688245003392 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
688245003393 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
688245003394 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
688245003395 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
688245003396 glutamate dehydrogenase; Provisional; Region: PRK09414
688245003397 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812
688245003398 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
688245003399 NAD(P) binding site; other site
688245003400 benzoate transport; Region: 2A0115; TIGR00895
688245003401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245003402 putative substrate translocation pore; other site
688245003403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245003404 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
688245003405 Transcriptional regulators [Transcription]; Region: RpiR; COG1737
688245003406 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013
688245003407 putative active site; other site
688245003408 DNA mismatch repair protein MutL; Region: mutl; TIGR00585
688245003409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245003410 ATP binding site; other site
688245003411 Mg2+ binding site; other site
688245003412 G-X-G motif; other site
688245003413 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
688245003414 ATP binding site; other site
688245003415 MutL C terminal dimerization domain; Region: MutL_C; cl07336
688245003416 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
688245003417 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
688245003418 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741
688245003419 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
688245003420 active site
688245003421 metal-binding site
688245003422 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
688245003423 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
688245003424 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
688245003425 Membrane transport protein; Region: Mem_trans; cl09117
688245003426 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245003427 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
688245003428 N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798
688245003429 Int/Topo IB signature motif; other site
688245003430 active site
688245003431 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
688245003432 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245003433 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
688245003434 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
688245003435 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
688245003436 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
688245003437 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
688245003438 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
688245003439 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
688245003440 dinuclear metal binding motif; other site
688245003441 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
688245003442 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
688245003443 trimer interface; other site
688245003444 putative metal binding site; other site
688245003445 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
688245003446 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
688245003447 dimerization interface; other site
688245003448 domain crossover interface; other site
688245003449 redox-dependent activation switch; other site
688245003450 Septum formation initiator; Region: DivIC; cl11433
688245003451 phosphopyruvate hydratase; Provisional; Region: eno; PRK00077
688245003452 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
688245003453 dimer interface; other site
688245003454 metal-binding site
688245003455 substrate binding pocket; other site
688245003456 NeuB family; Region: NeuB; cl00496
688245003457 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
688245003458 CTP synthetase; Validated; Region: pyrG; PRK05380
688245003459 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113
688245003460 UTP binding site; other site
688245003461 active site
688245003462 Catalytic site; other site
688245003463 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
688245003464 active site
688245003465 putative oxyanion hole; other site
688245003466 catalytic triad; other site
688245003467 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
688245003468 Flavoprotein; Region: Flavoprotein; cl08021
688245003469 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
688245003470 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
688245003471 trimer interface; other site
688245003472 active site
688245003473 sensor protein PhoQ; Provisional; Region: PRK10815
688245003474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245003475 ATP binding site; other site
688245003476 Mg2+ binding site; other site
688245003477 G-X-G motif; other site
688245003478 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
688245003479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245003480 active site
688245003481 phosphorylation site
688245003482 intermolecular recognition site; other site
688245003483 dimerization interface; other site
688245003484 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
688245003485 DNA binding site
688245003486 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
688245003487 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
688245003488 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; cl01353
688245003489 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
688245003490 NAD(P) binding site; other site
688245003491 catalytic residues; other site
688245003492 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
688245003493 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
688245003494 Walker A/P-loop; other site
688245003495 ATP binding site; other site
688245003496 Q-loop/lid; other site
688245003497 ABC transporter signature motif; other site
688245003498 Walker B; other site
688245003499 D-loop; other site
688245003500 H-loop/switch region; other site
688245003501 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
688245003502 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219
688245003503 Walker A/P-loop; other site
688245003504 ATP binding site; other site
688245003505 Q-loop/lid; other site
688245003506 ABC transporter signature motif; other site
688245003507 Walker B; other site
688245003508 D-loop; other site
688245003509 H-loop/switch region; other site
688245003510 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
688245003511 TM-ABC transporter signature motif; other site
688245003512 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
688245003513 TM-ABC transporter signature motif; other site
688245003514 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
688245003515 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338
688245003516 putative ligand binding site; other site
688245003517 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
688245003518 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
688245003519 FAD binding domain; Region: FAD_binding_4; cl10516
688245003520 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
688245003521 Cytochrome c; Region: Cytochrom_C; cl11414
688245003522 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
688245003523 NAD(P) binding site; other site
688245003524 catalytic residues; other site
688245003525 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
688245003526 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
688245003527 Uncharacterized conserved protein [Function unknown]; Region: COG2850
688245003528 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
688245003529 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
688245003530 Dihydrodipicolinate synthase (DHDPS) is a key enzyme in lysine biosynthesis. It catalyzes the aldol condensation of L-aspartate-beta- semialdehyde and pyruvate to dihydropicolinic acid via a Schiff base formation between pyruvate and a lysine residue...; Region: DHDPS; cd00950
688245003531 dihydrodipicolinate synthase; Region: dapA; TIGR00674
688245003532 dimer interface; other site
688245003533 active site
688245003534 catalytic residue; other site
688245003535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245003536 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
688245003537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245003538 Major Facilitator Superfamily; Region: MFS_1; pfam07690
688245003539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245003540 putative substrate translocation pore; other site
688245003541 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
688245003542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245003543 ATP binding site; other site
688245003544 Mg2+ binding site; other site
688245003545 G-X-G motif; other site
688245003546 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822
688245003547 anchoring element; other site
688245003548 dimer interface; other site
688245003549 ATP binding site; other site
688245003550 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
688245003551 active site
688245003552 metal-binding site
688245003553 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
688245003554 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254
688245003555 N-acetyl-D-glucosamine binding site; other site
688245003556 catalytic residue; other site
688245003557 DNA topoisomerase IV subunit A; Validated; Region: PRK05561
688245003558 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187
688245003559 CAP-like domain; other site
688245003560 active site
688245003561 primary dimer interface; other site
688245003562 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
688245003563 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245003564 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245003565 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
688245003566 dimerization interface; other site
688245003567 Bacterial Transmembrane Pair family; Region: BTP; pfam05232
688245003568 Bacterial Transmembrane Pair family; Region: BTP; pfam05232
688245003569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245003570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245003571 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
688245003572 pyridoxal binding site; other site
688245003573 dimer interface; other site
688245003574 ATP binding site; other site
688245003575 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
688245003576 homotrimer interaction site; other site
688245003577 putative active site; other site
688245003578 Competence protein; Region: Competence; cl00471
688245003579 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
688245003580 Uncharacterized conserved protein [Function unknown]; Region: COG2308
688245003581 Domain of unknown function (DUF404); Region: DUF404; pfam04169
688245003582 Domain of unknown function (DUF407); Region: DUF407; pfam04174
688245003583 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980
688245003584 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
688245003585 Ferritin-like domain; Region: Ferritin; pfam00210
688245003586 heme binding site; other site
688245003587 ferroxidase pore; other site
688245003588 ferroxidase diiron center; other site
688245003589 peroxiredoxin; Region: AhpC; TIGR03137
688245003590 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015
688245003591 dimer interface; other site
688245003592 decamer (pentamer of dimers) interface; other site
688245003593 catalytic triad; other site
688245003594 peroxidatic and resolving cysteines; other site
688245003595 Alkyl hydroperoxide reductase, large subunit [Posttranslational modification, protein turnover, chaperones]; Region: AhpF; COG3634
688245003596 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the...; Region: AhpF_NTD_N; cd02974
688245003597 catalytic residue; other site
688245003598 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
688245003599 catalytic residues; other site
688245003600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245003601 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
688245003602 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245003603 N-terminal plug; other site
688245003604 ligand-binding site; other site
688245003605 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720
688245003606 ChuX-like family; Region: DUF1008; cl01509
688245003607 ChuX-like family; Region: DUF1008; cl01509
688245003608 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262
688245003609 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
688245003610 intersubunit interface; other site
688245003611 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462
688245003612 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
688245003613 ABC-ATPase subunit interface; other site
688245003614 dimer interface; other site
688245003615 putative PBP binding regions; other site
688245003616 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
688245003617 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
688245003618 Walker A/P-loop; other site
688245003619 ATP binding site; other site
688245003620 Q-loop/lid; other site
688245003621 ABC transporter signature motif; other site
688245003622 Walker B; other site
688245003623 D-loop; other site
688245003624 H-loop/switch region; other site
688245003625 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
688245003626 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10632
688245003627 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245003628 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
688245003629 putative effector binding pocket; other site
688245003630 dimerization interface; other site
688245003631 Domain of unknown function (DUF299); Region: DUF299; cl00780
688245003632 phosphoenolpyruvate synthase; Validated; Region: PRK06464
688245003633 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
688245003634 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
688245003635 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl09155
688245003636 Predicted membrane protein [Function unknown]; Region: COG4327; cl01781
688245003637 Sodium:solute symporter family; Region: SSF; cl00456
688245003638 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
688245003639 Sodium:solute symporter family; Region: SSF; cl00456
688245003640 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
688245003641 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245003642 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
688245003643 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245003644 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
688245003645 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245003646 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
688245003647 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
688245003648 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
688245003649 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
688245003650 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
688245003651 Sigma-70 region 3; Region: Sigma70_r3; pfam04539
688245003652 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
688245003653 DNA binding residues
688245003654 DNA primase, catalytic core; Region: dnaG; TIGR01391
688245003655 CHC2 zinc finger; Region: zf-CHC2; cl02597
688245003656 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
688245003657 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
688245003658 active site
688245003659 metal-binding site
688245003660 interdomain interaction site; other site
688245003661 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
688245003662 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879
688245003663 acyl-CoA synthetase; Validated; Region: PRK08162
688245003664 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245003665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2908
688245003666 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
688245003667 putative active site; other site
688245003668 putative metal binding site; other site
688245003669 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
688245003670 active site
688245003671 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
688245003672 active site
688245003673 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
688245003674 TPR motif; other site
688245003675 binding surface
688245003676 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
688245003677 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
688245003678 active site
688245003679 HIGH motif; other site
688245003680 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
688245003681 KMSKS motif; other site
688245003682 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
688245003683 tRNA binding surface; other site
688245003684 anticodon binding site; other site
688245003685 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
688245003686 endonuclease III; Region: ENDO3c; smart00478
688245003687 minor groove reading motif; other site
688245003688 helix-hairpin-helix signature motif; other site
688245003689 substrate binding pocket; other site
688245003690 active site
688245003691 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513
688245003692 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
688245003693 Ligand Binding Site; other site
688245003694 aspartate kinase; Reviewed; Region: PRK06635
688245003695 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
688245003696 putative nucleotide binding site; other site
688245003697 putative catalytic residues; other site
688245003698 putative Mg ion binding site; other site
688245003699 putative aspartate binding site; other site
688245003700 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
688245003701 putative allosteric regulatory site; other site
688245003702 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
688245003703 putative allosteric regulatory residue; other site
688245003704 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
688245003705 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553
688245003706 active site
688245003707 uracil binding; other site
688245003708 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091
688245003709 active site
688245003710 substrate binding site; other site
688245003711 Mg2+ binding site; other site
688245003712 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
688245003713 RNA binding surface; other site
688245003714 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
688245003715 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
688245003716 dimer interface; other site
688245003717 phosphorylation site
688245003718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245003719 ATP binding site; other site
688245003720 Mg2+ binding site; other site
688245003721 G-X-G motif; other site
688245003722 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
688245003723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245003724 active site
688245003725 phosphorylation site
688245003726 intermolecular recognition site; other site
688245003727 dimerization interface; other site
688245003728 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
688245003729 DNA binding site
688245003730 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245003731 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
688245003732 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
688245003733 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245003734 Walker A motif; other site
688245003735 ATP binding site; other site
688245003736 Walker B motif; other site
688245003737 arginine finger; other site
688245003738 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
688245003739 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
688245003740 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
688245003741 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245003742 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
688245003743 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
688245003744 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328
688245003745 putative ligand binding site; other site
688245003746 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
688245003747 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219
688245003748 Walker A/P-loop; other site
688245003749 ATP binding site; other site
688245003750 Q-loop/lid; other site
688245003751 ABC transporter signature motif; other site
688245003752 Walker B; other site
688245003753 D-loop; other site
688245003754 H-loop/switch region; other site
688245003755 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
688245003756 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
688245003757 Walker A/P-loop; other site
688245003758 ATP binding site; other site
688245003759 Q-loop/lid; other site
688245003760 ABC transporter signature motif; other site
688245003761 Walker B; other site
688245003762 D-loop; other site
688245003763 H-loop/switch region; other site
688245003764 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
688245003765 TM-ABC transporter signature motif; other site
688245003766 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
688245003767 TM-ABC transporter signature motif; other site
688245003768 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605
688245003769 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
688245003770 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245003771 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245003772 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
688245003773 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
688245003774 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
688245003775 active site residue
688245003776 putative inner membrane protein; Provisional; Region: PRK11099
688245003777 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
688245003778 active site residue
688245003779 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
688245003780 active site residue
688245003781 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
688245003782 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799
688245003783 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196
688245003784 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315
688245003785 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
688245003786 FAD binding domain; Region: FAD_binding_4; cl10516
688245003787 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
688245003788 nucleoside/Zn binding site; other site
688245003789 dimer interface; other site
688245003790 catalytic motif; other site
688245003791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
688245003792 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
688245003793 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293
688245003794 Walker A/P-loop; other site
688245003795 ATP binding site; other site
688245003796 Q-loop/lid; other site
688245003797 ABC transporter signature motif; other site
688245003798 Walker B; other site
688245003799 D-loop; other site
688245003800 H-loop/switch region; other site
688245003801 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
688245003802 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
688245003803 substrate binding pocket; other site
688245003804 membrane-bound complex binding site; other site
688245003805 hinge residues; other site
688245003806 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
688245003807 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245003808 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
688245003809 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206
688245003810 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245003811 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245003812 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245003813 dimerization interface; other site
688245003814 ferrochelatase; Reviewed; Region: hemH; PRK00035
688245003815 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
688245003816 C-terminal domain interface; other site
688245003817 active site
688245003818 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
688245003819 active site
688245003820 N-terminal domain interface; other site
688245003821 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
688245003822 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
688245003823 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
688245003824 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245003825 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245003826 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
688245003827 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
688245003828 catalytic residues; other site
688245003829 substrate binding pocket; other site
688245003830 substrate-Mg2+ binding site; other site
688245003831 aspartate-rich region 1; other site
688245003832 aspartate-rich region 2; other site
688245003833 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
688245003834 active site lid residues
688245003835 substrate binding pocket; other site
688245003836 catalytic residues; other site
688245003837 substrate-Mg2+ binding site; other site
688245003838 aspartate-rich region 1; other site
688245003839 aspartate-rich region 2; other site
688245003840 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
688245003841 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
688245003842 trigger factor; Provisional; Region: tig; PRK01490
688245003843 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
688245003844 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
688245003845 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
688245003846 oligomer interface; other site
688245003847 active site residues
688245003848 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
688245003849 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
688245003850 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245003851 Walker A motif; other site
688245003852 ATP binding site; other site
688245003853 Walker B motif; other site
688245003854 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
688245003855 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
688245003856 Found in ATP-dependent protease La (LON); Region: LON; cl01056
688245003857 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245003858 Walker A motif; other site
688245003859 ATP binding site; other site
688245003860 Walker B motif; other site
688245003861 arginine finger; other site
688245003862 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
688245003863 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
688245003864 N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_N_terminal_like; cd03312
688245003865 THF binding site; other site
688245003866 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311
688245003867 substrate binding site; other site
688245003868 THF binding site; other site
688245003869 zinc-binding site; other site
688245003870 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245003871 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245003872 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
688245003873 putative dimerization interface; other site
688245003874 Major Facilitator Superfamily; Region: MFS_1; pfam07690
688245003875 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
688245003876 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
688245003877 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
688245003878 conserved cys residue; other site
688245003879 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
688245003880 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245003881 DNA binding site
688245003882 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688245003883 pyridoxal 5'-phosphate binding site; other site
688245003884 homodimer interface; other site
688245003885 catalytic residue; other site
688245003886 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513
688245003887 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
688245003888 tetramer interface; other site
688245003889 active site
688245003890 Mg2+/Mn2+ binding site; other site
688245003891 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245003892 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245003893 Propionate catabolism activator; Region: PrpR_N; pfam06506
688245003894 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
688245003895 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
688245003896 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245003897 Walker A motif; other site
688245003898 ATP binding site; other site
688245003899 Walker B motif; other site
688245003900 arginine finger; other site
688245003901 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
688245003902 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
688245003903 PAS fold; Region: PAS_3; pfam08447
688245003904 putative active site; other site
688245003905 heme pocket; other site
688245003906 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245003907 metal-binding site
688245003908 active site
688245003909 I-site; other site
688245003910 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
688245003911 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
688245003912 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
688245003913 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
688245003914 substrate binding site; other site
688245003915 ligand binding site; other site
688245003916 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
688245003917 substrate binding site; other site
688245003918 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245003919 DNA binding site
688245003920 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (...; Region: Ec2MCS_like_1; cd06117
688245003921 dimer interface; other site
688245003922 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
688245003923 active site
688245003924 oxalacetate/citrate binding site; other site
688245003925 citrylCoA binding site; other site
688245003926 coenzyme A binding site; other site
688245003927 catalytic triad; other site
688245003928 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
688245003929 Predicted transcriptional regulator [General function prediction only]; Region: COG3800
688245003930 Domain of unknown function (DUF955); Region: DUF955; cl01076
688245003931 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
688245003932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245003933 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
688245003934 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245003935 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
688245003936 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
688245003937 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
688245003938 FMN binding site; other site
688245003939 active site
688245003940 substrate binding site; other site
688245003941 catalytic residue; other site
688245003942 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
688245003943 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
688245003944 Coenzyme A transferase; Region: CoA_trans; cl00773
688245003945 Coenzyme A transferase; Region: CoA_trans; cl00773
688245003946 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
688245003947 substrate binding site; other site
688245003948 oxyanion hole (OAH) forming residues; other site
688245003949 trimer interface; other site
688245003950 2-nitropropane dioxygenase; Region: NPD; pfam03060
688245003951 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730
688245003952 FMN binding site; other site
688245003953 substrate binding site; other site
688245003954 putative catalytic residue; other site
688245003955 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
688245003956 enoyl-CoA hydratase; Provisional; Region: PRK06142
688245003957 substrate binding site; other site
688245003958 oxyanion hole (OAH) forming residues; other site
688245003959 trimer interface; other site
688245003960 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
688245003961 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
688245003962 FAD binding site; other site
688245003963 substrate binding site; other site
688245003964 catalytic base; other site
688245003965 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245003966 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245003967 active site
688245003968 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
688245003969 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
688245003970 dimer interface; other site
688245003971 active site
688245003972 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
688245003973 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
688245003974 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
688245003975 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
688245003976 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245003977 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
688245003978 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
688245003979 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
688245003980 Acyl-CoA dehydrogenase; Region: ACAD; cd00567
688245003981 active site
688245003982 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
688245003983 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245003984 active site
688245003985 short chain dehydrogenase; Provisional; Region: PRK07831
688245003986 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245003987 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
688245003988 putative active site; other site
688245003989 putative catalytic site; other site
688245003990 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
688245003991 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
688245003992 dimer interface; other site
688245003993 active site
688245003994 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
688245003995 DNA binding residues
688245003996 dimerization interface; other site
688245003997 Cache domain; Region: Cache_1; pfam02743
688245003998 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245003999 metal-binding site
688245004000 active site
688245004001 I-site; other site
688245004002 CoA-transferase family III; Region: CoA_transf_3; cl00778
688245004003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245004004 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
688245004005 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
688245004006 acetyl-CoA acetyltransferase; Validated; Region: PRK08242
688245004007 dimer interface; other site
688245004008 active site
688245004009 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
688245004010 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
688245004011 substrate binding site; other site
688245004012 oxyanion hole (OAH) forming residues; other site
688245004013 trimer interface; other site
688245004014 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245004015 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
688245004016 choline dehydrogenase; Validated; Region: PRK02106
688245004017 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
688245004018 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
688245004019 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
688245004020 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245004021 active site
688245004022 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
688245004023 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245004024 active site
688245004025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245004026 putative substrate translocation pore; other site
688245004027 Major Facilitator Superfamily; Region: MFS_1; pfam07690
688245004028 acyl-CoA synthetase; Validated; Region: PRK07798
688245004029 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245004030 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245004031 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
688245004032 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
688245004033 active site
688245004034 putative substrate binding pocket; other site
688245004035 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
688245004036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245004037 Major Facilitator Superfamily; Region: MFS_1; pfam07690
688245004038 putative substrate translocation pore; other site
688245004039 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
688245004040 [2Fe-2S] cluster binding site; other site
688245004041 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245004042 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
688245004043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245004044 putative substrate translocation pore; other site
688245004045 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
688245004046 NAD(P) binding site; other site
688245004047 catalytic residues; other site
688245004048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245004049 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
688245004050 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245004051 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245004052 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
688245004053 putative effector binding pocket; other site
688245004054 dimerization interface; other site
688245004055 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
688245004056 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
688245004057 catalytic residues; other site
688245004058 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
688245004059 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
688245004060 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl10490
688245004061 Acetyltransferases [General function prediction only]; Region: RimI; COG0456
688245004062 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
688245004063 Coenzyme A binding pocket; other site
688245004064 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435
688245004065 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
688245004066 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as...; Region: OYE_like_FMN_family; cd02803
688245004067 active site
688245004068 FMN binding site; other site
688245004069 substrate binding site; other site
688245004070 putative catalytic residue; other site
688245004071 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
688245004072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245004073 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245004074 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
688245004075 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
688245004076 active site
688245004077 FMN binding site; other site
688245004078 2,4-decadienoyl-CoA binding site; other site
688245004079 catalytic residue; other site
688245004080 4Fe-4S cluster binding site; other site
688245004081 putative oxidoreductase; Provisional; Region: PRK11749
688245004082 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245004083 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
688245004084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245004085 ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon...; Region: ketosteroid_isomerase; cd00781
688245004086 dimer interface; other site
688245004087 active site/substrate binding site
688245004088 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00443
688245004089 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
688245004090 C-term; Region: GreA_GreB; pfam01272
688245004091 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00443
688245004092 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245004093 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245004094 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
688245004095 putative effector binding pocket; other site
688245004096 putative dimerization interface; other site
688245004097 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245004098 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
688245004099 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
688245004100 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
688245004101 enoyl-CoA hydratase; Provisional; Region: PRK05980
688245004102 substrate binding site; other site
688245004103 oxyanion hole (OAH) forming residues; other site
688245004104 trimer interface; other site
688245004105 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245004106 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
688245004107 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
688245004108 DUF35 OB-fold domain; Region: DUF35; pfam01796
688245004109 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
688245004110 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
688245004111 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245004112 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455
688245004113 putative active site; other site
688245004114 putative catalytic site; other site
688245004115 lipid-transfer protein; Provisional; Region: PRK07855
688245004116 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829
688245004117 active site
688245004118 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
688245004119 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245004120 active site
688245004121 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
688245004122 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245004123 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
688245004124 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245004125 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
688245004126 active site
688245004127 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
688245004128 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
688245004129 Acyl-CoA dehydrogenase; Region: ACAD; cd00567
688245004130 active site
688245004131 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
688245004132 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245004133 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
688245004134 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
688245004135 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
688245004136 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
688245004137 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
688245004138 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
688245004139 Ycf48-like protein; Provisional; Region: PRK13684
688245004140 thiolase; Provisional; Region: PRK06158
688245004141 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829
688245004142 active site
688245004143 DUF35 OB-fold domain; Region: DUF35; pfam01796
688245004144 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
688245004145 active site 2
688245004146 active site 1
688245004147 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
688245004148 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245004149 N-terminal plug; other site
688245004150 ligand-binding site; other site
688245004151 4-hydroxy-2-ketovalerate aldolase; Validated; Region: PRK08195
688245004152 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
688245004153 active site
688245004154 catalytic residues; other site
688245004155 metal-binding site
688245004156 DmpG-like communication domain; Region: DmpG_comm; pfam07836
688245004157 acetaldehyde dehydrogenase; Validated; Region: PRK08300
688245004158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245004159 Prokaryotic acetaldehyde dehydrogenase, dimerization; Region: AcetDehyd-dimer; pfam09290
688245004160 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
688245004161 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
688245004162 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245004163 Flavin Reductases; Region: FlaRed; cl00801
688245004164 Transcriptional regulators [Transcription]; Region: MarR; COG1846
688245004165 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245004166 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245004167 active site
688245004168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245004169 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835
688245004170 hypothetical protein; Validated; Region: PRK07121
688245004171 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245004172 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
688245004173 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase...; Region: PA_degradation_oxidoreductase_like; cd06214
688245004174 FAD binding pocket; other site
688245004175 FAD binding motif; other site
688245004176 phosphate binding motif; other site
688245004177 beta-alpha-beta structure motif; other site
688245004178 NAD(p) ribose binding residues; other site
688245004179 NAD binding pocket; other site
688245004180 NAD(P)-pyrophosphate-nicotinamide binding residues; other site
688245004181 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
688245004182 catalytic loop; other site
688245004183 iron binding site; other site
688245004184 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
688245004185 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245004186 Protein of unknown function DUF45; Region: DUF45; cl00636
688245004187 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
688245004188 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
688245004189 Coenzyme A binding pocket; other site
688245004190 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
688245004191 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
688245004192 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676
688245004193 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676
688245004194 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
688245004195 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
688245004196 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
688245004197 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
688245004198 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
688245004199 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
688245004200 CrcB-like protein; Region: CRCB; cl09114
688245004201 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
688245004202 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048
688245004203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245004204 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
688245004205 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
688245004206 Coenzyme A binding pocket; other site
688245004207 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851
688245004208 Fumarase C-terminus; Region: Fumerase_C; cl00795
688245004209 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
688245004210 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
688245004211 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
688245004212 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245004213 metal-binding site
688245004214 active site
688245004215 I-site; other site
688245004216 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
688245004217 fumarate hydratase; Reviewed; Region: fumC; PRK00485
688245004218 Class II fumarases; Region: Fumarase_classII; cd01362
688245004219 active site
688245004220 tetramer interface; other site
688245004221 Putative ParB-like nuclease; Region: ParBc_2; cl01772
688245004222 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
688245004223 Permease family; Region: Xan_ur_permease; cl00967
688245004224 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
688245004225 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747
688245004226 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
688245004227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245004228 putative substrate translocation pore; other site
688245004229 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245004230 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
688245004231 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cd00216
688245004232 Trp docking motif; other site
688245004233 'Velcro' closure; other site
688245004234 active site
688245004235 Cytochrome c; Region: Cytochrom_C; cl11414
688245004236 Protein of unknown function (DUF3334); Region: DUF3334; pfam11813
688245004237 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245004238 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
688245004239 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245004240 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
688245004241 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245004242 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
688245004243 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
688245004244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245004245 dimer interface; other site
688245004246 conserved gate region; other site
688245004247 putative PBP binding loops; other site
688245004248 ABC-ATPase subunit interface; other site
688245004249 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
688245004250 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294
688245004251 Walker A/P-loop; other site
688245004252 ATP binding site; other site
688245004253 Q-loop/lid; other site
688245004254 ABC transporter signature motif; other site
688245004255 Walker B; other site
688245004256 D-loop; other site
688245004257 H-loop/switch region; other site
688245004258 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
688245004259 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078
688245004260 acetyl-CoA synthetase; Provisional; Region: PRK00174
688245004261 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
688245004262 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245004263 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245004264 argininosuccinate synthase; Validated; Region: PRK05370
688245004265 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292
688245004266 Ligand Binding Site; other site
688245004267 Protein of unknown function (DUF1255); Region: DUF1255; cl01202
688245004268 Rickettsia 17 kDa surface antigen; Region: Rick_17kDa_Anti; cl10470
688245004269 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
688245004270 putative catalytic residues; other site
688245004271 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
688245004272 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
688245004273 Sporulation related domain; Region: SPOR; cl10051
688245004274 Colicin V production protein; Region: Colicin_V; cl00567
688245004275 amidophosphoribosyltransferase; Provisional; Region: PRK09246
688245004276 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
688245004277 tetramer interface; other site
688245004278 active site
688245004279 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
688245004280 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
688245004281 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
688245004282 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
688245004283 homodimer interface; other site
688245004284 substrate-cofactor binding pocket; other site
688245004285 pyridoxal 5'-phosphate binding site; other site
688245004286 catalytic residue; other site
688245004287 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
688245004288 catalytic core domain of descriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
688245004289 active site
688245004290 HIGH motif; other site
688245004291 catalytic core domain of descriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
688245004292 KMSKS motif; other site
688245004293 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
688245004294 Outer membrane efflux protein; Region: OEP; pfam02321
688245004295 Outer membrane efflux protein; Region: OEP; pfam02321
688245004296 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
688245004297 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
688245004298 Nitrogen regulatory protein P-II; Region: P-II; cl00412
688245004299 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245004300 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
688245004301 Phasin protein; Region: Phasin_2; cl11491
688245004302 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586
688245004303 active site
688245004304 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
688245004305 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: PncB_like; cd01401
688245004306 active site
688245004307 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688245004308 glyoxylate reductase; Reviewed; Region: PRK13243
688245004309 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245004310 macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397
688245004311 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
688245004312 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
688245004313 RmuC family; Region: RmuC; pfam02646
688245004314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245004315 Major Facilitator Superfamily; Region: MFS_1; pfam07690
688245004316 putative substrate translocation pore; other site
688245004317 tetratricopeptide repeat protein; Provisional; Region: PRK11788
688245004318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
688245004319 binding surface
688245004320 TPR motif; other site
688245004321 Protein of unknown function (DUF1049); Region: DUF1049; cl01539
688245004322 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591
688245004323 IHF dimer interface; other site
688245004324 IHF - DNA interface; other site
688245004325 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
688245004326 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
688245004327 RNA binding site; other site
688245004328 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
688245004329 RNA binding site; other site
688245004330 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
688245004331 RNA binding site; other site
688245004332 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec4; cd05689
688245004333 RNA binding site; other site
688245004334 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690
688245004335 RNA binding site; other site
688245004336 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691
688245004337 RNA binding site; other site
688245004338 bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidine monophosphate kinase; Provisional; Region: PRK11860
688245004339 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556
688245004340 hinge; other site
688245004341 active site
688245004342 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
688245004343 CMP-binding site; other site
688245004344 The sites determining sugar specificity; other site
688245004345 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
688245004346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245004347 Chorismate mutase type II; Region: CM_2; cl00693
688245004348 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
688245004349 Prephenate dehydratase; Region: PDT; pfam00800
688245004350 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
688245004351 putative L-Phe binding site; other site
688245004352 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
688245004353 pyridoxal 5'-phosphate binding pocket; other site
688245004354 catalytic residue; other site
688245004355 DNA gyrase subunit A; Validated; Region: PRK05560
688245004356 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187
688245004357 CAP-like domain; other site
688245004358 active site
688245004359 primary dimer interface; other site
688245004360 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
688245004361 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
688245004362 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
688245004363 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
688245004364 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
688245004365 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
688245004366 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
688245004367 ligand binding site; other site
688245004368 3-demethylubiquinone-9 3-methyltransferase; Provisional; Region: PRK05134
688245004369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
688245004370 S-adenosylmethionine binding site; other site
688245004371 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
688245004372 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
688245004373 motif II; other site
688245004374 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
688245004375 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
688245004376 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
688245004377 Phage integrase family; Region: Phage_integrase; pfam00589
688245004378 DNA binding site
688245004379 Int/Topo IB signature motif; other site
688245004380 active site
688245004381 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245004382 metal-binding site
688245004383 active site
688245004384 I-site; other site
688245004385 Putative exonuclease, RdgC; Region: RdgC; cl01122
688245004386 Sensors of blue-light using FAD; Region: BLUF; pfam04940
688245004387 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
688245004388 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
688245004389 non-specific DNA binding site; other site
688245004390 salt bridge; other site
688245004391 sequence-specific DNA binding site; other site
688245004392 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
688245004393 Poly(A) polymerase [RNA processing and modification]; Region: PAP1; COG5186
688245004394 Gas vesicle protein G; Region: GvpG; pfam05120
688245004395 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl01302
688245004396 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450
688245004397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245004398 active site
688245004399 phosphorylation site
688245004400 intermolecular recognition site; other site
688245004401 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
688245004402 DNA binding residues
688245004403 dimerization interface; other site
688245004404 integrase; Provisional; Region: PRK09692
688245004405 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
688245004406 Int/Topo IB signature motif; other site
688245004407 active site
688245004408 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868
688245004409 FAD binding pocket; other site
688245004410 phosphate binding motif; other site
688245004411 beta-alpha-beta structure motif; other site
688245004412 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342
688245004413 trimer interface; other site
688245004414 eyelet of channel; other site
688245004415 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245004416 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245004417 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
688245004418 Transposase DDE domain; Region: Transposase_11; pfam01609
688245004419 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
688245004420 Integrase core domain; Region: rve; cl01316
688245004421 cation-binding hemerythrin HHE family protein; Provisional; Region: PRK01917
688245004422 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl11605
688245004423 octamerization interface; other site
688245004424 diferric-oxygen binding site; other site
688245004425 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
688245004426 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron...; Region: PDR_like; cd06185
688245004427 FMN-binding pocket; other site
688245004428 flavin binding motif; other site
688245004429 phosphate binding motif; other site
688245004430 beta-alpha-beta structure motif; other site
688245004431 NAD binding pocket; other site
688245004432 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
688245004433 catalytic loop; other site
688245004434 iron binding site; other site
688245004435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245004436 d-galactonate transporter; Region: 2A0114; TIGR00893
688245004437 putative substrate translocation pore; other site
688245004438 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
688245004439 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245004440 Transcriptional regulators [Transcription]; Region: MarR; COG1846
688245004441 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245004442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245004443 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
688245004444 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3,4...; Region: Rieske_RO_Alpha_PhDO_like; cd03479
688245004445 putative transposase OrfB; Reviewed; Region: PHA02517
688245004446 Integrase core domain; Region: rve; cl01316
688245004447 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
688245004448 Transposase; Region: Transposase_9; pfam01548
688245004449 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
688245004450 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
688245004451 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245004452 Bacterial transcriptional regulator; Region: IclR; pfam01614
688245004453 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245004454 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938
688245004455 iron-sulfur cluster; other site
688245004456 [2Fe-2S] cluster binding site; other site
688245004457 Ring hydroxylating alpha subunit (catalytic domain). This CD includes the catalytic domain (alpha) of aromatic-ring-hydroxylating dioxygenase systems of eubacteria. Eubacterial ring hydroxylating dioxygenases are multicomponent 1,2-dioxygenase...; Region: Ring_hydroxylating_alpha; cd00680
688245004458 interface residues; other site
688245004459 active site
688245004460 substrate binding pocket; other site
688245004461 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
688245004462 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
688245004463 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
688245004464 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
688245004465 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
688245004466 catalytic loop; other site
688245004467 iron binding site; other site
688245004468 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD...; Region: flavin_oxioreductase; cd06189
688245004469 FAD binding pocket; other site
688245004470 FAD binding motif; other site
688245004471 phosphate binding motif; other site
688245004472 beta-alpha-beta structure motif; other site
688245004473 NAD binding pocket; other site
688245004474 potential frameshift: common BLAST hit: gi|76810996|ref|YP_333177.1| integrase core subunit
688245004475 Integrase core domain; Region: rve; cl01316
688245004476 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
688245004477 non-specific DNA binding site; other site
688245004478 salt bridge; other site
688245004479 sequence-specific DNA binding site; other site
688245004480 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
688245004481 Domain of unknown function (DUF932); Region: DUF932; cl12129
688245004482 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl01302
688245004483 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
688245004484 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
688245004485 HsdM N-terminal domain; Region: HsdM_N; pfam12161
688245004486 N-6 DNA Methylase; Region: N6_Mtase; pfam02384
688245004487 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245004488 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
688245004489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245004490 active site
688245004491 phosphorylation site
688245004492 intermolecular recognition site; other site
688245004493 dimerization interface; other site
688245004494 hypothetical protein; Provisional; Region: PRK13560
688245004495 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
688245004496 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245004497 metal-binding site
688245004498 active site
688245004499 I-site; other site
688245004500 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
688245004501 CHASE domain; Region: CHASE; cl01369
688245004502 PAS domain S-box; Region: sensory_box; TIGR00229
688245004503 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
688245004504 hypothetical protein; Provisional; Region: PRK13560
688245004505 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
688245004506 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
688245004507 putative active site; other site
688245004508 heme pocket; other site
688245004509 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
688245004510 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
688245004511 dimer interface; other site
688245004512 phosphorylation site
688245004513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245004514 ATP binding site; other site
688245004515 Mg2+ binding site; other site
688245004516 G-X-G motif; other site
688245004517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245004518 active site
688245004519 phosphorylation site
688245004520 intermolecular recognition site; other site
688245004521 dimerization interface; other site
688245004522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245004523 active site
688245004524 phosphorylation site
688245004525 intermolecular recognition site; other site
688245004526 dimerization interface; other site
688245004527 Transposase DDE domain; Region: Transposase_11; pfam01609
688245004528 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
688245004529 Transposase; Region: Transposase_9; pfam01548
688245004530 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
688245004531 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
688245004532 Transposase DDE domain; Region: Transposase_11; pfam01609
688245004533 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
688245004534 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245004535 CHASE domain; Region: CHASE; cl01369
688245004536 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
688245004537 putative active site; other site
688245004538 PAS fold; Region: PAS_3; pfam08447
688245004539 heme pocket; other site
688245004540 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245004541 metal-binding site
688245004542 active site
688245004543 I-site; other site
688245004544 potential frameshift: common BLAST hit: gi|110639316|ref|YP_679525.1| restriction/modification methyltransferase
688245004545 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
688245004546 HsdM N-terminal domain; Region: HsdM_N; pfam12161
688245004547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245004548 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
688245004549 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
688245004550 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
688245004551 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
688245004552 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl01057
688245004553 Transposase DDE domain; Region: Transposase_11; pfam01609
688245004554 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
688245004555 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
688245004556 Phage integrase family; Region: Phage_integrase; pfam00589
688245004557 DNA binding site
688245004558 Int/Topo IB signature motif; other site
688245004559 active site
688245004560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245004561 Putative exonuclease, RdgC; Region: RdgC; cl01122
688245004562 Sensors of blue-light using FAD; Region: BLUF; pfam04940
688245004563 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
688245004564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245004565 Walker A motif; other site
688245004566 ATP binding site; other site
688245004567 Walker B motif; other site
688245004568 arginine finger; other site
688245004569 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393
688245004570 active site
688245004571 Zn-binding site; other site
688245004572 helicase 45; Provisional; Region: PTZ00424
688245004573 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268
688245004574 ATP binding site; other site
688245004575 Mg++ binding site; other site
688245004576 motif III; other site
688245004577 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
688245004578 nucleotide binding region; other site
688245004579 ATP-binding site; other site
688245004580 Transcriptional regulatory protein LGE1; Region: Lge1; pfam11488
688245004581 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
688245004582 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245004583 Walker A/P-loop; other site
688245004584 ATP binding site; other site
688245004585 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245004586 Q-loop/lid; other site
688245004587 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
688245004588 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
688245004589 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
688245004590 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly...; Region: nylC_like; cd02252
688245004591 putative active site pocket; other site
688245004592 cleavage site
688245004593 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245004594 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245004595 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
688245004596 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
688245004597 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747
688245004598 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
688245004599 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363
688245004600 Protein of unknown function, DUF; Region: DUF411; cl01142
688245004601 Multicopper oxidase; Region: Cu-oxidase; cl11412
688245004602 Multicopper oxidase; Region: Cu-oxidase; cl11412
688245004603 Multicopper oxidase; Region: Cu-oxidase; cl11412
688245004604 Outer membrane efflux protein; Region: OEP; pfam02321
688245004605 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
688245004606 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
688245004607 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
688245004608 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
688245004609 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
688245004610 DNA binding residues
688245004611 dimer interface; other site
688245004612 putative metal binding site; other site
688245004613 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
688245004614 mce related protein; Region: MCE; pfam02470
688245004615 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342
688245004616 trimer interface; other site
688245004617 eyelet of channel; other site
688245004618 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
688245004619 ABC-ATPase subunit interface; other site
688245004620 dimer interface; other site
688245004621 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462
688245004622 dimer interface; other site
688245004623 putative PBP binding regions; other site
688245004624 ABC-ATPase subunit interface; other site
688245004625 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957
688245004626 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262
688245004627 intersubunit interface; other site
688245004628 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253
688245004629 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
688245004630 Walker A/P-loop; other site
688245004631 ATP binding site; other site
688245004632 Q-loop/lid; other site
688245004633 ABC transporter signature motif; other site
688245004634 Walker B; other site
688245004635 D-loop; other site
688245004636 H-loop/switch region; other site
688245004637 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245004638 Transcriptional regulator [Transcription]; Region: IclR; COG1414
688245004639 Bacterial transcriptional regulator; Region: IclR; pfam01614
688245004640 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
688245004641 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245004642 N-terminal plug; other site
688245004643 ligand-binding site; other site
688245004644 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
688245004645 active site
688245004646 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
688245004647 non-prolyl cis peptide bond; other site
688245004648 Protein of unknown function (DUF454); Region: DUF454; cl01063
688245004649 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
688245004650 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
688245004651 substrate binding site; other site
688245004652 oxyanion hole (OAH) forming residues; other site
688245004653 trimer interface; other site
688245004654 Protein of unknown function DUF72; Region: DUF72; cl00777
688245004655 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
688245004656 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl11430
688245004657 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685
688245004658 RNA binding site; other site
688245004659 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
688245004660 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
688245004661 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
688245004662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944
688245004663 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
688245004664 DNA binding residues
688245004665 dimerization interface; other site
688245004666 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
688245004667 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245004668 ATP binding site; other site
688245004669 Mg2+ binding site; other site
688245004670 G-X-G motif; other site
688245004671 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
688245004672 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
688245004673 Domain of unknown function DUF20; Region: UPF0118; cl00465
688245004674 Domain of unknown function DUF20; Region: UPF0118; cl00465
688245004675 GAF domain; Region: GAF; cl00853
688245004676 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
688245004677 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
688245004678 putative active site; other site
688245004679 metal-binding site
688245004680 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342
688245004681 trimer interface; other site
688245004682 eyelet of channel; other site
688245004683 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; cl10449
688245004684 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
688245004685 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799
688245004686 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
688245004687 FAD binding domain; Region: FAD_binding_4; cl10516
688245004688 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
688245004689 4-hydroxybenzoyl-CoA reductase, alpha subunit; Region: 4hydrxCoA_A; TIGR03194
688245004690 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315
688245004691 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
688245004692 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245004693 Transcriptional regulators [Transcription]; Region: MarR; COG1846
688245004694 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245004695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245004696 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
688245004697 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
688245004698 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
688245004699 ferrichrome outer membrane transporter; Provisional; Region: PRK10044
688245004700 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245004701 N-terminal plug; other site
688245004702 ligand-binding site; other site
688245004703 Nickel uptake substrate-specific transmembrane region; Region: NikM; pfam10670
688245004704 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
688245004705 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
688245004706 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245004707 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
688245004708 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586
688245004709 active site
688245004710 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00443
688245004711 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
688245004712 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
688245004713 YceG-like family; Region: YceG; pfam02618
688245004714 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
688245004715 dimerization interface; other site
688245004716 thymidylate kinase; Validated; Region: tmk; PRK00698
688245004717 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672
688245004718 TMP-binding site; other site
688245004719 ATP-binding site; other site
688245004720 DNA polymerase III, delta' subunit; Region: holB; TIGR00678
688245004721 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245004722 PilZ domain; Region: PilZ; cl01260
688245004723 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449
688245004724 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
688245004725 active site
688245004726 ankyrin repeat protein; Provisional; Region: PHA03100
688245004727 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
688245004728 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
688245004729 ABC transporter transmembrane region; Region: ABC_membrane; cl00549
688245004730 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
688245004731 Walker A/P-loop; other site
688245004732 ATP binding site; other site
688245004733 Q-loop/lid; other site
688245004734 ABC transporter signature motif; other site
688245004735 Walker B; other site
688245004736 D-loop; other site
688245004737 H-loop/switch region; other site
688245004738 translocation protein TolB; Provisional; Region: tolB; PRK02889
688245004739 TolB amino-terminal domain; Region: TolB_N; pfam04052
688245004740 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
688245004741 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
688245004742 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
688245004743 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
688245004744 ligand binding site; other site
688245004745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
688245004746 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429
688245004747 binding surface
688245004748 TPR motif; other site
688245004749 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
688245004750 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin...; Region: YgdL_like; cd00755
688245004751 putative ATP binding site; other site
688245004752 putative substrate interface; other site
688245004753 Cytochrome c; Region: Cytochrom_C; cl11414
688245004754 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
688245004755 dinuclear metal binding motif; other site
688245004756 RNA polymerase sigma factor; Provisional; Region: PRK11922
688245004757 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
688245004758 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
688245004759 DNA binding residues
688245004760 GAF domain; Region: GAF; cl00853
688245004761 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
688245004762 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
688245004763 DNA binding residues
688245004764 MiaB-like tRNA modifying enzyme YliG, TIGR01125; Region: TIGR01125
688245004765 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
688245004766 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
688245004767 FeS/SAM binding site; other site
688245004768 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323
688245004769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245004770 Walker A motif; other site
688245004771 ATP binding site; other site
688245004772 Walker B motif; other site
688245004773 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245004774 arginine finger; other site
688245004775 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
688245004776 Uncharacterized BCR, YbaB family COG0718; Region: DUF149; cl00494
688245004777 recombination protein RecR; Reviewed; Region: recR; PRK00076
688245004778 RecR protein; Region: RecR; pfam02132
688245004779 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
688245004780 putative active site; other site
688245004781 putative metal-binding site; other site
688245004782 tetramer interface; other site
688245004783 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
688245004784 MLTD_N; Region: MLTD_N; pfam06474
688245004785 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254
688245004786 N-acetyl-D-glucosamine binding site; other site
688245004787 catalytic residue; other site
688245004788 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
688245004789 putative peptidoglycan binding site; other site
688245004790 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
688245004791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245004792 RNase H (RNase HI) is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a not sequence-specific manner. One of the important functions of RNase H is to remove Okazaki fragments during DNA replication. RNase H knockout mice lack...; Region: RnaseH; cd06222
688245004793 RNA/DNA hybrid binding site; other site
688245004794 active site
688245004795 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
688245004796 catalytic residues; other site
688245004797 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
688245004798 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
688245004799 dimer interface; other site
688245004800 putative functional site; other site
688245004801 putative MPT binding site; other site
688245004802 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
688245004803 GTP binding site; other site
688245004804 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
688245004805 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
688245004806 FeS/SAM binding site; other site
688245004807 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
688245004808 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
688245004809 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
688245004810 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
688245004811 ligand binding site; other site
688245004812 flexible hinge region; other site
688245004813 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245004814 Protein of unknown function (DUF962); Region: DUF962; cl01879
688245004815 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
688245004816 dimer interface; other site
688245004817 substrate binding site; other site
688245004818 metal binding sites; metal-binding site
688245004819 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
688245004820 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
688245004821 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144
688245004822 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
688245004823 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
688245004824 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144
688245004825 FemAB family; Region: FemAB; cl11444
688245004826 NAD synthetase; Provisional; Region: PRK13981
688245004827 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
688245004828 multimer interface; other site
688245004829 active site
688245004830 catalytic triad; other site
688245004831 protein interface 1; other site
688245004832 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553
688245004833 homodimer interface; other site
688245004834 NAD binding pocket; other site
688245004835 ATP binding pocket; other site
688245004836 Mg binding site; other site
688245004837 active-site loop
688245004838 Nitrogen regulatory protein P-II; Region: P-II; cl00412
688245004839 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
688245004840 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526
688245004841 RDD family; Region: RDD; cl00746
688245004842 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
688245004843 Protein of unknown function (DUF3619); Region: DUF3619; pfam12279
688245004844 RNA polymerase factor sigma-70; Validated; Region: PRK09047
688245004845 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
688245004846 DNA binding residues
688245004847 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965
688245004848 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
688245004849 PYR/PP interface; other site
688245004850 dimer interface; other site
688245004851 TPP binding site; other site
688245004852 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
688245004853 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
688245004854 TPP-binding site; other site
688245004855 dimer interface; other site
688245004856 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
688245004857 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
688245004858 putative valine binding site; other site
688245004859 dimer interface; other site
688245004860 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
688245004861 ketol-acid reductoisomerase; Provisional; Region: PRK05479
688245004862 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245004863 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
688245004864 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
688245004865 2-isopropylmalate synthase; Validated; Region: PRK03739
688245004866 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
688245004867 active site
688245004868 catalytic residues; other site
688245004869 metal-binding site
688245004870 LeuA allosteric (dimerization) domain; Region: LeuA_dimer; pfam08502
688245004871 2-isopropylmalate synthase; Validated; Region: PRK00915
688245004872 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
688245004873 active site
688245004874 catalytic residues; other site
688245004875 metal-binding site
688245004876 LeuA allosteric (dimerization) domain; Region: LeuA_dimer; pfam08502
688245004877 Beta-lactamase; Region: Beta-lactamase; cl01009
688245004878 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
688245004879 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245004880 Transcriptional regulator [Transcription]; Region: IclR; COG1414
688245004881 Bacterial transcriptional regulator; Region: IclR; pfam01614
688245004882 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
688245004883 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
688245004884 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
688245004885 Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl01006
688245004886 elongation factor P; Validated; Region: PRK00529
688245004887 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
688245004888 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470
688245004889 RNA binding site; other site
688245004890 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794
688245004891 RNA binding site; other site
688245004892 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; cl01823
688245004893 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245004894 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
688245004895 putative dimerization interface; other site
688245004896 CoA-transferase family III; Region: CoA_transf_3; cl00778
688245004897 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
688245004898 active site
688245004899 catalytic residues; other site
688245004900 metal-binding site
688245004901 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245004902 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
688245004903 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061
688245004904 UvrB/uvrC motif; Region: UVR; pfam02151
688245004905 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
688245004906 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
688245004907 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591
688245004908 IHF dimer interface; other site
688245004909 IHF - DNA interface; other site
688245004910 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245004911 metal-binding site
688245004912 active site
688245004913 I-site; other site
688245004914 Putative exonuclease, RdgC; Region: RdgC; cl01122
688245004915 peptidyl-prolyl cis-trans isomerase (rotamase D); Provisional; Region: PRK10788
688245004916 PPIC-type PPIASE domain; Region: Rotamase; cl08278
688245004917 Protein of unknown function (DUF1641); Region: DUF1641; cl01025
688245004918 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
688245004919 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
688245004920 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
688245004921 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
688245004922 rRNA binding site; other site
688245004923 predicted 30S ribosome binding site; other site
688245004924 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
688245004925 PII uridylyl-transferase; Provisional; Region: PRK03059
688245004926 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
688245004927 metal binding triad; other site
688245004928 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
688245004929 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
688245004930 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
688245004931 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
688245004932 methionine aminopeptidase; Reviewed; Region: PRK07281
688245004933 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
688245004934 active site
688245004935 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
688245004936 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203
688245004937 dimerization interface; other site
688245004938 ATP binding site; other site
688245004939 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204
688245004940 dimerization interface; other site
688245004941 ATP binding site; other site
688245004942 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
688245004943 putative active site; other site
688245004944 catalytic triad; other site
688245004945 SWIM zinc finger; Region: SWIM; cl11618
688245004946 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
688245004947 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: VWA_YIEM_type; cd01462
688245004948 metal ion-dependent adhesion site (MIDAS); other site
688245004949 Protein of unknown function (DUF808); Region: DUF808; cl01002
688245004950 Surface antigen; Region: Surface_Ag_2; cl01155
688245004951 probable methyltransferase; Region: TIGR03438
688245004952 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
688245004953 conserved hypothetical protein TIGR03440; Region: unchr_TIGR03440
688245004954 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556
688245004955 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
688245004956 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
688245004957 homodimer interface; other site
688245004958 substrate-cofactor binding pocket; other site
688245004959 pyridoxal 5'-phosphate binding site; other site
688245004960 catalytic residue; other site
688245004961 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245004962 metal-binding site
688245004963 active site
688245004964 I-site; other site
688245004965 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
688245004966 active site
688245004967 enoyl-CoA hydratase; Provisional; Region: PRK05980
688245004968 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
688245004969 substrate binding site; other site
688245004970 oxyanion hole (OAH) forming residues; other site
688245004971 trimer interface; other site
688245004972 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
688245004973 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245004974 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245004975 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
688245004976 active site
688245004977 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245004978 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
688245004979 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
688245004980 active site
688245004981 catalytic site; other site
688245004982 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
688245004983 active site
688245004984 catalytic site; other site
688245004985 lipid-transfer protein; Provisional; Region: PRK08256
688245004986 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829
688245004987 active site
688245004988 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
688245004989 SurA N-terminal domain; Region: SurA_N; pfam09312
688245004990 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
688245004991 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
688245004992 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245004993 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
688245004994 3-methylcrotonyl-CoA carboxylase; Region: PLN02820
688245004995 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513
688245004996 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
688245004997 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245004998 active site
688245004999 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
688245005000 enoyl-CoA hydratase; Provisional; Region: PRK06142
688245005001 substrate binding site; other site
688245005002 oxyanion hole (OAH) forming residues; other site
688245005003 trimer interface; other site
688245005004 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cl11392
688245005005 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
688245005006 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
688245005007 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
688245005008 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
688245005009 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850
688245005010 carboxyltransferase (CT) interaction site; other site
688245005011 biotinylation site; other site
688245005012 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245005013 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
688245005014 active site
688245005015 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl01276
688245005016 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
688245005017 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245005018 short chain dehydrogenase; Provisional; Region: PRK07576
688245005019 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245005020 acyl-CoA synthetase; Validated; Region: PRK08316
688245005021 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245005022 hypothetical protein; Provisional; Region: PRK06194
688245005023 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245005024 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
688245005025 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245005026 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
688245005027 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245005028 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245005029 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
688245005030 substrate binding pocket; other site
688245005031 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
688245005032 Peptidase family U32; Region: Peptidase_U32; pfam01136
688245005033 Collagenase; Region: DUF3656; pfam12392
688245005034 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883
688245005035 nudix motif; other site
688245005036 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447
688245005037 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; cl00804
688245005038 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl01869
688245005039 Domain of unknown function (DUF1768); Region: DUF1768; cl01271
688245005040 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
688245005041 potential protein location (hypothetical protein) that overlaps protein (methyl-accepting chemotaxis protein)
688245005042 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
688245005043 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
688245005044 dimerization interface; other site
688245005045 ligand binding site; other site
688245005046 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
688245005047 nucleoside/Zn binding site; other site
688245005048 dimer interface; other site
688245005049 catalytic motif; other site
688245005050 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245005051 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
688245005052 dimer interface; other site
688245005053 catalytic triad; other site
688245005054 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
688245005055 elongation factor G; Reviewed; Region: PRK00007
688245005056 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886
688245005057 G1 box; other site
688245005058 putative GEF interaction site; other site
688245005059 GTP/Mg2+ binding site; other site
688245005060 Switch I region; other site
688245005061 G2 box; other site
688245005062 G3 box; other site
688245005063 Switch II region; other site
688245005064 G4 box; other site
688245005065 G5 box; other site
688245005066 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088
688245005067 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434
688245005068 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713
688245005069 Protein related to penicillin acylase [General function prediction only]; Region: COG2366
688245005070 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7...; Region: Ntn_PGA_like; cd03747
688245005071 active site
688245005072 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245005073 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
688245005074 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245005075 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
688245005076 active site
688245005077 catalytic tetrad; other site
688245005078 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS); Region: YbaK_deacylase; cd00002
688245005079 putative deacylase active site; other site
688245005080 Domain of unknown function (DUF205); Region: DUF205; cl00410
688245005081 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
688245005082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245005083 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262
688245005084 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
688245005085 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
688245005086 catalytic motif; other site
688245005087 Catalytic residue; other site
688245005088 Protein of unknown function (DUF520); Region: DUF520; cl00723
688245005089 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
688245005090 FAD binding domain; Region: FAD_binding_4; cl10516
688245005091 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
688245005092 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848
688245005093 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
688245005094 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
688245005095 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
688245005096 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
688245005097 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
688245005098 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245005099 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
688245005100 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
688245005101 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
688245005102 Sel1 repeat; Region: Sel1; cl02723
688245005103 Sel1 repeat; Region: Sel1; cl02723
688245005104 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
688245005105 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
688245005106 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
688245005107 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
688245005108 Protein export membrane protein; Region: SecD_SecF; cl14618
688245005109 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
688245005110 Outer membrane efflux protein; Region: OEP; pfam02321
688245005111 Outer membrane efflux protein; Region: OEP; pfam02321
688245005112 RNA polymerase sigma factor; Provisional; Region: PRK12528
688245005113 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
688245005114 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
688245005115 DNA binding residues
688245005116 fec operon regulator FecR; Reviewed; Region: PRK09774
688245005117 FecR protein; Region: FecR; pfam04773
688245005118 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
688245005119 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245005120 N-terminal plug; other site
688245005121 ligand-binding site; other site
688245005122 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
688245005123 NfeD-like; Region: NfeD; cl00686
688245005124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944
688245005125 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
688245005126 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
688245005127 pyridoxal 5'-phosphate binding pocket; other site
688245005128 catalytic residue; other site
688245005129 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
688245005130 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245005131 CoA-transferase family III; Region: CoA_transf_3; cl00778
688245005132 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
688245005133 active site
688245005134 catalytic residues; other site
688245005135 metal-binding site
688245005136 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245005137 Transcriptional regulator [Transcription]; Region: IclR; COG1414
688245005138 Bacterial transcriptional regulator; Region: IclR; pfam01614
688245005139 DNA ligase; Provisional; Region: PRK09125
688245005140 The Adenylation domain of kDNA ligase and similar proteins, which is involved in kDNA replication or repair, is a component of the catalytic core unit; Region: Adenylation_kDNA_ligase_like; cd07896
688245005141 DNA binding site
688245005142 active site
688245005143 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041
688245005144 DNA binding site
688245005145 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
688245005146 E-class dimer interface; other site
688245005147 P-class dimer interface; other site
688245005148 active site
688245005149 Cu2+ binding site; other site
688245005150 Zn2+ binding site; other site
688245005151 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997
688245005152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245005153 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
688245005154 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
688245005155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245005156 dimer interface; other site
688245005157 conserved gate region; other site
688245005158 ABC-ATPase subunit interface; other site
688245005159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245005160 dimer interface; other site
688245005161 conserved gate region; other site
688245005162 putative PBP binding loops; other site
688245005163 ABC-ATPase subunit interface; other site
688245005164 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
688245005165 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
688245005166 Walker A/P-loop; other site
688245005167 ATP binding site; other site
688245005168 Q-loop/lid; other site
688245005169 ABC transporter signature motif; other site
688245005170 Walker B; other site
688245005171 D-loop; other site
688245005172 H-loop/switch region; other site
688245005173 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
688245005174 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
688245005175 Walker A/P-loop; other site
688245005176 ATP binding site; other site
688245005177 Q-loop/lid; other site
688245005178 ABC transporter signature motif; other site
688245005179 Walker B; other site
688245005180 D-loop; other site
688245005181 H-loop/switch region; other site
688245005182 curved DNA-binding protein CbpA; Provisional; Region: PRK10266
688245005183 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257
688245005184 HSP70 interaction site; other site
688245005185 DnaJ C terminal region; Region: DnaJ_C; pfam01556
688245005186 DnaJ C terminal region; Region: DnaJ_C; pfam01556
688245005187 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
688245005188 catalytic residues; other site
688245005189 hypothetical protein; Reviewed; Region: PRK00092
688245005190 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259
688245005191 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259
688245005192 Sm1 motif; other site
688245005193 RNA binding pocket; other site
688245005194 transcription elongation factor NusA; Validated; Region: nusA; PRK09202
688245005195 NusA N-terminal domain; Region: NusA_N; pfam08529
688245005196 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455
688245005197 RNA binding site; other site
688245005198 homodimer interface; other site
688245005199 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
688245005200 G-X-X-G motif; other site
688245005201 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
688245005202 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
688245005203 translation initiation factor IF-2; Validated; Region: infB; PRK05306
688245005204 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
688245005205 translation initiation factor IF-2; Region: IF-2; TIGR00487
688245005206 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
688245005207 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887
688245005208 G1 box; other site
688245005209 putative GEF interaction site; other site
688245005210 GTP/Mg2+ binding site; other site
688245005211 Switch I region; other site
688245005212 G2 box; other site
688245005213 G3 box; other site
688245005214 Switch II region; other site
688245005215 G4 box; other site
688245005216 G5 box; other site
688245005217 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702
688245005218 Translation-initiation factor 2; Region: IF-2; pfam11987
688245005219 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692
688245005220 Ribosome-binding factor A; Region: RBFA; cl00542
688245005221 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851
688245005222 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573
688245005223 RNA binding site; other site
688245005224 active site
688245005225 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
688245005226 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891
688245005227 G1 box; other site
688245005228 putative GEF interaction site; other site
688245005229 GTP/Mg2+ binding site; other site
688245005230 Switch I region; other site
688245005231 G2 box; other site
688245005232 G3 box; other site
688245005233 Switch II region; other site
688245005234 G4 box; other site
688245005235 G5 box; other site
688245005236 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
688245005237 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710
688245005238 Cytochrome c; Region: Cytochrom_C; cl11414
688245005239 Dehydratase family; Region: ILVD_EDD; cl00340
688245005240 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110
688245005241 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245005242 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
688245005243 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292
688245005244 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245005245 malonyl-CoA synthase; Validated; Region: PRK07514
688245005246 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245005247 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245005248 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
688245005249 Ligand Binding Site; other site
688245005250 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
688245005251 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
688245005252 metal-binding site
688245005253 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
688245005254 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
688245005255 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253
688245005256 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the...; Region: cbb3_Oxidase_I; cd01661
688245005257 Putative water exit pathway; other site
688245005258 Binuclear center (active site); other site
688245005259 Putative proton exit pathway; other site
688245005260 Low-spin heme binding site; other site
688245005261 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
688245005262 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of...; Region: cbb3_Oxidase_CcoQ; cl00282
688245005263 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
688245005264 Cytochrome c; Region: Cytochrom_C; cl11414
688245005265 Cytochrome c; Region: Cytochrom_C; cl11414
688245005266 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
688245005267 Ubp3 associated protein Bre5; Region: Bre5; pfam11614
688245005268 FixH; Region: FixH; cl01254
688245005269 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
688245005270 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
688245005271 ligand binding site; other site
688245005272 flexible hinge region; other site
688245005273 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
688245005274 putative switch regulator; other site
688245005275 non-specific DNA interactions; other site
688245005276 DNA binding site
688245005277 sequence specific DNA binding site; other site
688245005278 putative cAMP binding site; other site
688245005279 coproporphyrinogen III oxidase; Provisional; Region: PRK09249
688245005280 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
688245005281 FeS/SAM binding site; other site
688245005282 HemN C-terminal region; Region: HemN_C; pfam06969
688245005283 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515
688245005284 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
688245005285 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
688245005286 Zn2+ binding site; other site
688245005287 Mg2+ binding site; other site
688245005288 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
688245005289 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
688245005290 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
688245005291 putative active site; other site
688245005292 heme pocket; other site
688245005293 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245005294 metal-binding site
688245005295 active site
688245005296 I-site; other site
688245005297 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
688245005298 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
688245005299 DNA binding residues
688245005300 dimerization interface; other site
688245005301 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245005302 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
688245005303 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
688245005304 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245005305 metal-binding site
688245005306 active site
688245005307 I-site; other site
688245005308 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245005309 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245005310 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
688245005311 putative dimerization interface; other site
688245005312 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
688245005313 conserved cys residue; other site
688245005314 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
688245005315 aspartate racemase; Region: asp_race; TIGR00035
688245005316 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
688245005317 hypothetical protein; Provisional; Region: PRK10281
688245005318 Transcriptional regulators [Transcription]; Region: MarR; COG1846
688245005319 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245005320 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron...; Region: PDR_like; cd06185
688245005321 beta-alpha-beta structure motif; other site
688245005322 NAD binding pocket; other site
688245005323 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
688245005324 catalytic loop; other site
688245005325 iron binding site; other site
688245005326 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
688245005327 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938
688245005328 iron-sulfur cluster; other site
688245005329 [2Fe-2S] cluster binding site; other site
688245005330 benzoate transport; Region: 2A0115; TIGR00895
688245005331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245005332 putative substrate translocation pore; other site
688245005333 Staphylococcal nuclease homologues; Region: SNc; smart00318
688245005334 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
688245005335 Catalytic site; other site
688245005336 Cell division protein ZapA; Region: ZapA; cl01146
688245005337 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
688245005338 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245005339 N-terminal plug; other site
688245005340 ligand-binding site; other site
688245005341 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
688245005342 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras; Region: Ras_like_GTPase; cl10444
688245005343 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
688245005344 catalytic triad; other site
688245005345 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is...; Region: CobU; cd00544
688245005346 homotrimer interface; other site
688245005347 Walker A motif; other site
688245005348 GTP binding site; other site
688245005349 Walker B motif; other site
688245005350 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
688245005351 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
688245005352 putative binding site residues; other site
688245005353 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462
688245005354 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462
688245005355 putative PBP binding regions; other site
688245005356 ABC-ATPase subunit interface; other site
688245005357 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
688245005358 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
688245005359 Walker A/P-loop; other site
688245005360 ATP binding site; other site
688245005361 Q-loop/lid; other site
688245005362 ABC transporter signature motif; other site
688245005363 Walker B; other site
688245005364 D-loop; other site
688245005365 H-loop/switch region; other site
688245005366 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a...; Region: CobA_CobO_BtuR; cd00561
688245005367 homodimer interface; other site
688245005368 Walker A motif; other site
688245005369 ATP binding site; other site
688245005370 hydroxycobalamin binding site; other site
688245005371 Walker B motif; other site
688245005372 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD...; Region: BluB; cd02145
688245005373 putative FMN binding site; other site
688245005374 CobD/Cbib protein; Region: CobD_Cbib; cl00561
688245005375 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
688245005376 pyridoxal 5'-phosphate binding pocket; other site
688245005377 catalytic residue; other site
688245005378 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236
688245005379 cobyric acid synthase; Provisional; Region: PRK00784
688245005380 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras; Region: Ras_like_GTPase; cl10444
688245005381 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
688245005382 catalytic triad; other site
688245005383 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
688245005384 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
688245005385 putative dimer interface; other site
688245005386 active site pocket
688245005387 putative cataytic base; other site
688245005388 endonuclease III; Provisional; Region: PRK10702
688245005389 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
688245005390 minor groove reading motif; other site
688245005391 helix-hairpin-helix signature motif; other site
688245005392 substrate binding pocket; other site
688245005393 active site
688245005394 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
688245005395 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
688245005396 putative aminotransferase; Validated; Region: PRK09082
688245005397 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688245005398 pyridoxal 5'-phosphate binding site; other site
688245005399 homodimer interface; other site
688245005400 catalytic residue; other site
688245005401 SlyX; Region: SlyX; cl01090
688245005402 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346
688245005403 amidohydrolase; Region: amidohydrolases; TIGR01891
688245005404 Peptidase dimerization domain; Region: M20_dimer; cl09126
688245005405 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245005406 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
688245005407 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
688245005408 substrate binding pocket; other site
688245005409 membrane-bound complex binding site; other site
688245005410 hinge residues; other site
688245005411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245005412 dimer interface; other site
688245005413 conserved gate region; other site
688245005414 putative PBP binding loops; other site
688245005415 ABC-ATPase subunit interface; other site
688245005416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245005417 dimer interface; other site
688245005418 conserved gate region; other site
688245005419 putative PBP binding loops; other site
688245005420 ABC-ATPase subunit interface; other site
688245005421 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245005422 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245005423 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245005424 dimerization interface; other site
688245005425 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
688245005426 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
688245005427 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
688245005428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245005429 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
688245005430 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
688245005431 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
688245005432 Precorrin-8X methylmutase; Region: CbiC; cl00913
688245005433 precorrin-3B synthase; Region: CobG; TIGR02435
688245005434 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
688245005435 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
688245005436 metal ion-dependent adhesion site (MIDAS); other site
688245005437 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245005438 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
688245005439 Walker A motif; other site
688245005440 ATP binding site; other site
688245005441 Walker B motif; other site
688245005442 arginine finger; other site
688245005443 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
688245005444 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
688245005445 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
688245005446 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras; Region: Ras_like_GTPase; cl10444
688245005447 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
688245005448 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_N; cd03416
688245005449 putative active site; other site
688245005450 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH...; Region: TRX_Fd_family; cd02980
688245005451 dimer interface; other site
688245005452 [2Fe-2S] cluster binding site; other site
688245005453 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
688245005454 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
688245005455 Walker A/P-loop; other site
688245005456 ATP binding site; other site
688245005457 Q-loop/lid; other site
688245005458 ABC transporter signature motif; other site
688245005459 Walker B; other site
688245005460 D-loop; other site
688245005461 H-loop/switch region; other site
688245005462 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
688245005463 ABC-ATPase subunit interface; other site
688245005464 dimer interface; other site
688245005465 putative PBP binding regions; other site
688245005466 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
688245005467 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
688245005468 putative ligand binding residues; other site
688245005469 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
688245005470 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245005471 N-terminal plug; other site
688245005472 ligand-binding site; other site
688245005473 Integrase core domain; Region: rve; cl01316
688245005474 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
688245005475 hypothetical protein; Provisional; Region: PRK09775
688245005476 HipA-like N-terminal domain; Region: HipA_N; pfam07805
688245005477 HipA-like C-terminal domain; Region: HipA_C; pfam07804
688245005478 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245005479 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245005480 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245005481 dimerization interface; other site
688245005482 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
688245005483 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
688245005484 conserved cys residue; other site
688245005485 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
688245005486 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
688245005487 active site residue
688245005488 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245005489 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245005490 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
688245005491 putative dimerization interface; other site
688245005492 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245005493 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
688245005494 Integrase core domain; Region: rve; cl01316
688245005495 Integrase core domain; Region: rve; cl01316
688245005496 putative transposase OrfB; Reviewed; Region: PHA02517
688245005497 Anti-sigma-K factor rskA; Region: RskA; cl02208
688245005498 RNA polymerase sigma factor; Provisional; Region: PRK12537
688245005499 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
688245005500 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055
688245005501 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937
688245005502 Predicted membrane protein [Function unknown]; Region: COG3174
688245005503 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
688245005504 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245005505 metal-binding site
688245005506 active site
688245005507 I-site; other site
688245005508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245005509 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150
688245005510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245005511 short chain dehydrogenase; Provisional; Region: PRK07024
688245005512 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
688245005513 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
688245005514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
688245005515 S-adenosylmethionine binding site; other site
688245005516 Protein of unknown function (DUF1365); Region: DUF1365; cl01388
688245005517 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
688245005518 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245005519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245005520 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
688245005521 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
688245005522 potential frameshift: common BLAST hit: gi|226945664|ref|YP_002800737.1| Bacterial regulatory protein, GntR
688245005523 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
688245005524 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245005525 DNA binding site
688245005526 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688245005527 pyridoxal 5'-phosphate binding site; other site
688245005528 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
688245005529 Sulfatase; Region: Sulfatase; cl10460
688245005530 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245005531 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
688245005532 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245005533 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
688245005534 NAD(P) binding site; other site
688245005535 catalytic residues; other site
688245005536 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
688245005537 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
688245005538 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
688245005539 shikimate binding site; other site
688245005540 NAD(P) binding site; other site
688245005541 choline dehydrogenase; Validated; Region: PRK02106
688245005542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245005543 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
688245005544 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
688245005545 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
688245005546 Ligand binding site; other site
688245005547 potential frameshift: common BLAST hit: gi|160897832|ref|YP_001563414.1| electron transfer flavoprotein alpha subunit
688245005548 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
688245005549 etfA (electron transfer flavoprotein alpha subunit); Provisional; Region: PLN00022
688245005550 Domain of unknown function DUF; Region: DUF202; cl09954
688245005551 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
688245005552 DNA binding site
688245005553 Int/Topo IB signature motif; other site
688245005554 active site
688245005555 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
688245005556 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
688245005557 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245005558 Walker A motif; other site
688245005559 ATP binding site; other site
688245005560 Walker B motif; other site
688245005561 arginine finger; other site
688245005562 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
688245005563 Integrase core domain; Region: rve; cl01316
688245005564 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
688245005565 non-specific DNA binding site; other site
688245005566 salt bridge; other site
688245005567 sequence-specific DNA binding site; other site
688245005568 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
688245005569 Phage integrase family; Region: Phage_integrase; pfam00589
688245005570 DNA binding site
688245005571 Int/Topo IB signature motif; other site
688245005572 active site
688245005573 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
688245005574 Phage integrase family; Region: Phage_integrase; pfam00589
688245005575 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182
688245005576 DNA binding site
688245005577 Int/Topo IB signature motif; other site
688245005578 active site
688245005579 catalytic residues; other site
688245005580 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
688245005581 chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348
688245005582 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245005583 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245005584 dimerization interface; other site
688245005585 LysE type translocator; Region: LysE; cl00565
688245005586 Transcriptional regulators [Transcription]; Region: Lrp; COG1522
688245005587 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245005588 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245005589 threonine and homoserine efflux system; Provisional; Region: PRK10532
688245005590 EamA-like transporter family; Region: EamA; cl01037
688245005591 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766
688245005592 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245005593 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
688245005594 Protein of unknown function (DUF444); Region: DUF444; pfam04285
688245005595 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
688245005596 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; cl01044
688245005597 SpoVR like protein; Region: SpoVR; pfam04293
688245005598 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245005599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530
688245005600 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245005601 metal-binding site
688245005602 active site
688245005603 I-site; other site
688245005604 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
688245005605 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
688245005606 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055
688245005607 fec operon regulator FecR; Reviewed; Region: PRK09774
688245005608 FecR protein; Region: FecR; pfam04773
688245005609 Secretin and TonB N terminus short domain; Region: STN; pfam07660
688245005610 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
688245005611 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245005612 N-terminal plug; other site
688245005613 ligand-binding site; other site
688245005614 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
688245005615 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055
688245005616 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
688245005617 FecR protein; Region: FecR; pfam04773
688245005618 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
688245005619 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245005620 N-terminal plug; other site
688245005621 ligand-binding site; other site
688245005622 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
688245005623 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
688245005624 NADPH-dependent FMN reductase; Region: FMN_red; cl00438
688245005625 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
688245005626 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
688245005627 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245005628 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397
688245005629 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
688245005630 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588
688245005631 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
688245005632 ATP binding site; other site
688245005633 putative Mg++ binding site; other site
688245005634 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
688245005635 nucleotide binding region; other site
688245005636 ATP-binding site; other site
688245005637 TRCF domain; Region: TRCF; pfam03461
688245005638 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
688245005639 substrate binding site; other site
688245005640 dimer interface; other site
688245005641 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554
688245005642 homotrimer interaction site; other site
688245005643 zinc binding site; other site
688245005644 CDP-binding sites; other site
688245005645 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
688245005646 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
688245005647 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080
688245005648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245005649 ATP binding site; other site
688245005650 Mg2+ binding site; other site
688245005651 G-X-G motif; other site
688245005652 osmolarity response regulator; Provisional; Region: ompR; PRK09468
688245005653 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245005654 active site
688245005655 phosphorylation site
688245005656 intermolecular recognition site; other site
688245005657 dimerization interface; other site
688245005658 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
688245005659 DNA binding site
688245005660 Protein of unknown function (DUF541); Region: SIMPL; cl01077
688245005661 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394
688245005662 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245005663 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
688245005664 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
688245005665 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
688245005666 synthetase active site; other site
688245005667 NTP binding site; other site
688245005668 metal-binding site
688245005669 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668
688245005670 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
688245005671 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
688245005672 Integrase core domain; Region: rve; cl01316
688245005673 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
688245005674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245005675 Walker A motif; other site
688245005676 ATP binding site; other site
688245005677 Walker B motif; other site
688245005678 arginine finger; other site
688245005679 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
688245005680 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182
688245005681 DNA binding site
688245005682 Int/Topo IB signature motif; other site
688245005683 active site
688245005684 catalytic residues; other site
688245005685 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl01302
688245005686 Anti-sigma-K factor rskA; Region: RskA; cl02208
688245005687 RNA polymerase sigma factor; Provisional; Region: PRK12514
688245005688 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
688245005689 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
688245005690 DNA binding residues
688245005691 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
688245005692 dinuclear metal binding motif; other site
688245005693 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937
688245005694 Transposase; Region: Transposase_12; pfam01610
688245005695 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
688245005696 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150
688245005697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245005698 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765
688245005699 DNA photolyase; Region: DNA_photolyase; pfam00875
688245005700 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
688245005701 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
688245005702 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
688245005703 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
688245005704 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245005705 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
688245005706 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
688245005707 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
688245005708 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
688245005709 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans...; Region: HisKA; cd00082
688245005710 dimer interface; other site
688245005711 phosphorylation site
688245005712 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245005713 ATP binding site; other site
688245005714 Mg2+ binding site; other site
688245005715 G-X-G motif; other site
688245005716 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
688245005717 substrate binding pocket; other site
688245005718 membrane-bound complex binding site; other site
688245005719 hinge residues; other site
688245005720 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
688245005721 Zn2+ binding site; other site
688245005722 Mg2+ binding site; other site
688245005723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245005724 active site
688245005725 phosphorylation site
688245005726 intermolecular recognition site; other site
688245005727 dimerization interface; other site
688245005728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944
688245005729 active site
688245005730 phosphorylation site
688245005731 intermolecular recognition site; other site
688245005732 dimerization interface; other site
688245005733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245005734 active site
688245005735 phosphorylation site
688245005736 intermolecular recognition site; other site
688245005737 dimerization interface; other site
688245005738 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
688245005739 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
688245005740 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
688245005741 dimerization interface; other site
688245005742 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
688245005743 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144
688245005744 potential frameshift: common BLAST hit: gi|160897199|ref|YP_001562781.1| integrase catalytic region
688245005745 Integrase core domain; Region: rve; cl01316
688245005746 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
688245005747 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
688245005748 heme-binding site; other site
688245005749 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
688245005750 PAS fold; Region: PAS_3; pfam08447
688245005751 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245005752 metal-binding site
688245005753 active site
688245005754 I-site; other site
688245005755 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
688245005756 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
688245005757 PAS fold; Region: PAS_3; pfam08447
688245005758 putative active site; other site
688245005759 heme pocket; other site
688245005760 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
688245005761 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
688245005762 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144
688245005763 Phage integrase family; Region: Phage_integrase; pfam00589
688245005764 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182
688245005765 DNA binding site
688245005766 Int/Topo IB signature motif; other site
688245005767 active site
688245005768 catalytic residues; other site
688245005769 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
688245005770 Cytochrome C biogenesis protein; Region: CcmH; cl01179
688245005771 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
688245005772 catalytic residues; other site
688245005773 central insert; other site
688245005774 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
688245005775 CcmE; Region: CcmE; cl00994
688245005776 Heme exporter protein D (CcmD); Region: CcmD; cl11475
688245005777 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
688245005778 CcmB protein; Region: CcmB; cl01016
688245005779 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245005780 Walker A/P-loop; other site
688245005781 ATP binding site; other site
688245005782 Q-loop/lid; other site
688245005783 ABC transporter signature motif; other site
688245005784 Walker B; other site
688245005785 D-loop; other site
688245005786 H-loop/switch region; other site
688245005787 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl09485
688245005788 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
688245005789 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153
688245005790 nitrate reductase catalytic subunit; Provisional; Region: PRK13532
688245005791 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_Nitrate-R-NapA-like; cd02754
688245005792 [4Fe-4S] binding site; other site
688245005793 molybdopterin cofactor binding site; other site
688245005794 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
688245005795 molybdopterin cofactor binding site; other site
688245005796 NapD protein; Region: NapD; cl01163
688245005797 Periplasmic nitrate reductase protein NapE; Region: NapE; cl01848
688245005798 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245005799 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
688245005800 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; cl10449
688245005801 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
688245005802 Protein of unknown function (DUF1214); Region: DUF1214; cl08447
688245005803 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
688245005804 CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which...; Region: CysN_ATPS; cd04166
688245005805 CysD dimerization site; other site
688245005806 G1 box; other site
688245005807 putative GEF interaction site; other site
688245005808 GTP/Mg2+ binding site; other site
688245005809 Switch I region; other site
688245005810 G2 box; other site
688245005811 G3 box; other site
688245005812 Switch II region; other site
688245005813 G4 box; other site
688245005814 G5 box; other site
688245005815 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695
688245005816 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NoDQ_III; cd04095
688245005817 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027
688245005818 ligand-binding site; other site
688245005819 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
688245005820 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
688245005821 Active Sites; active site
688245005822 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638
688245005823 active site
688245005824 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245005825 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245005826 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245005827 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
688245005828 putative effector binding pocket; other site
688245005829 putative dimerization interface; other site
688245005830 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
688245005831 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868
688245005832 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799
688245005833 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
688245005834 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
688245005835 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
688245005836 DNA polymerase type-B family; Region: POLBc; smart00486
688245005837 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
688245005838 DNA polymerase family B; Region: DNA_pol_B; pfam00136
688245005839 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
688245005840 active site
688245005841 metal-binding site
688245005842 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245005843 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245005844 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245005845 dimerization interface; other site
688245005846 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245005847 hypothetical protein; Provisional; Region: PRK06126
688245005848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245005849 allantoate amidohydrolase; Reviewed; Region: PRK09290
688245005850 Peptidase dimerization domain; Region: M20_dimer; cl09126
688245005851 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
688245005852 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245005853 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245005854 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
688245005855 putative dimerization interface; other site
688245005856 YeeE/YedE family (DUF395); Region: DUF395; cl01018
688245005857 YeeE/YedE family (DUF395); Region: DUF395; cl01018
688245005858 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
688245005859 dimerization interface; other site
688245005860 putative DNA binding site; other site
688245005861 putative Zn2+ binding site; other site
688245005862 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
688245005863 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
688245005864 Uncharacterized conserved protein [Function unknown]; Region: COG5361
688245005865 Protein of unknown function (DUF1254); Region: DUF1254; cl02257
688245005866 Protein of unknown function (DUF1214); Region: DUF1214; cl08447
688245005867 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
688245005868 Uncharacterized conserved protein [Function unknown]; Region: COG5361
688245005869 Protein of unknown function (DUF1254); Region: DUF1254; cl02257
688245005870 Protein of unknown function (DUF1214); Region: DUF1214; cl08447
688245005871 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
688245005872 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein...; Region: ABC_MetN_methionine_transporter; cd03258
688245005873 Walker A/P-loop; other site
688245005874 ATP binding site; other site
688245005875 Q-loop/lid; other site
688245005876 ABC transporter signature motif; other site
688245005877 Walker B; other site
688245005878 D-loop; other site
688245005879 H-loop/switch region; other site
688245005880 NIL domain; Region: NIL; pfam09383
688245005881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245005882 dimer interface; other site
688245005883 conserved gate region; other site
688245005884 ABC-ATPase subunit interface; other site
688245005885 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
688245005886 generic binding surface I; other site
688245005887 generic binding surface II; other site
688245005888 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245005889 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a...; Region: Nitroreductase; cd02136
688245005890 putative FMN binding site; other site
688245005891 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
688245005892 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
688245005893 dimer interface; other site
688245005894 active site
688245005895 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245005896 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
688245005897 BioY family; Region: BioY; cl00560
688245005898 Cobalt transport protein; Region: CbiQ; cl00463
688245005899 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225
688245005900 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
688245005901 Walker A/P-loop; other site
688245005902 ATP binding site; other site
688245005903 Q-loop/lid; other site
688245005904 ABC transporter signature motif; other site
688245005905 Walker B; other site
688245005906 D-loop; other site
688245005907 H-loop/switch region; other site
688245005908 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
688245005909 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245005910 N-terminal plug; other site
688245005911 ligand-binding site; other site
688245005912 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245005913 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080
688245005914 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893
688245005915 putative catalytic cysteine; other site
688245005916 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
688245005917 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245005918 Walker A/P-loop; other site
688245005919 ATP binding site; other site
688245005920 Q-loop/lid; other site
688245005921 ABC transporter signature motif; other site
688245005922 Walker B; other site
688245005923 D-loop; other site
688245005924 H-loop/switch region; other site
688245005925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
688245005926 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
688245005927 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245005928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245005929 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
688245005930 NADPH-dependent FMN reductase; Region: FMN_red; cl00438
688245005931 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245005932 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245005933 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
688245005934 putative effector binding pocket; other site
688245005935 putative dimerization interface; other site
688245005936 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245005937 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245005938 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245005939 dimer interface; other site
688245005940 conserved gate region; other site
688245005941 putative PBP binding loops; other site
688245005942 ABC-ATPase subunit interface; other site
688245005943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245005944 dimer interface; other site
688245005945 conserved gate region; other site
688245005946 putative PBP binding loops; other site
688245005947 ABC-ATPase subunit interface; other site
688245005948 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
688245005949 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a solute-...; Region: ABC_CysA_sulfate_importer; cd03296
688245005950 Walker A/P-loop; other site
688245005951 ATP binding site; other site
688245005952 Q-loop/lid; other site
688245005953 ABC transporter signature motif; other site
688245005954 Walker B; other site
688245005955 D-loop; other site
688245005956 H-loop/switch region; other site
688245005957 Disulfide bond formation protein DsbB; Region: DsbB; cl00649
688245005958 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
688245005959 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
688245005960 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cl02776
688245005961 N-terminal domain interface; other site
688245005962 dimer interface; other site
688245005963 substrate binding pocket (H-site); other site
688245005964 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
688245005965 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245005966 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245005967 dimerization interface; other site
688245005968 Beta-lactamase; Region: Beta-lactamase; cl01009
688245005969 RNA polymerase sigma factor; Reviewed; Region: PRK12527
688245005970 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055
688245005971 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
688245005972 FecR protein; Region: FecR; pfam04773
688245005973 Secretin and TonB N terminus short domain; Region: STN; pfam07660
688245005974 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
688245005975 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245005976 N-terminal plug; other site
688245005977 ligand-binding site; other site
688245005978 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
688245005979 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
688245005980 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
688245005981 putative ion selectivity filter; other site
688245005982 putative pore gating glutamate residue; other site
688245005983 putative H+/Cl- coupling transport residue; other site
688245005984 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161
688245005985 ribonucleotide reductase-like protein; Provisional; Region: PRK06948
688245005986 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
688245005987 dimer interface; other site
688245005988 active site
688245005989 effector binding site; other site
688245005990 2-isopropylmalate synthase; Validated; Region: PRK03739
688245005991 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
688245005992 active site
688245005993 catalytic residues; other site
688245005994 metal-binding site
688245005995 LeuA allosteric (dimerization) domain; Region: LeuA_dimer; pfam08502
688245005996 Cupin domain; Region: Cupin_2; cl09118
688245005997 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
688245005998 N-acetylglutamate synthase; Validated; Region: PRK05279
688245005999 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an N-...; Region: AAK_NAGS-ABP; cd04237
688245006000 putative feedback inhibition sensing region; other site
688245006001 putative nucleotide binding site; other site
688245006002 putative substrate binding site; other site
688245006003 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
688245006004 Coenzyme A binding pocket; other site
688245006005 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
688245006006 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
688245006007 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
688245006008 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130
688245006009 ATP binding site; other site
688245006010 Walker A motif; other site
688245006011 hexamer interface; other site
688245006012 Walker B motif; other site
688245006013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245006014 active site
688245006015 phosphorylation site
688245006016 intermolecular recognition site; other site
688245006017 dimerization interface; other site
688245006018 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
688245006019 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly...; Region: CpaE_like; cd03111
688245006020 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly...; Region: CpaE_like; cd03111
688245006021 TadE-like protein; Region: TadE; pfam07811
688245006022 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
688245006023 TadE-like protein; Region: TadE; pfam07811
688245006024 Flp/Fap pilin component; Region: Flp_Fap; cl01585
688245006025 Flp/Fap pilin component; Region: Flp_Fap; cl01585
688245006026 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
688245006027 Bacterial type II and III secretion system protein; Region: Secretin; cl02829
688245006028 SAF domain; Region: SAF; cl00555
688245006029 Type IV leader peptidase family; Region: Peptidase_A24; cl02077
688245006030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245006031 Major Facilitator Superfamily; Region: MFS_1; pfam07690
688245006032 putative substrate translocation pore; other site
688245006033 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
688245006034 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245006035 N-terminal plug; other site
688245006036 ligand-binding site; other site
688245006037 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439
688245006038 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
688245006039 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245006040 Predicted membrane protein [Function unknown]; Region: COG5373
688245006041 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
688245006042 active site
688245006043 metal-binding site
688245006044 DEAD-like helicases superfamily; Region: DEXDc; smart00487
688245006045 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
688245006046 ATP binding site; other site
688245006047 putative Mg++ binding site; other site
688245006048 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
688245006049 nucleotide binding region; other site
688245006050 ATP-binding site; other site
688245006051 Helicase associated domain (HA2); Region: HA2; cl04503
688245006052 Domain of unknown function (DUF1605); Region: DUF1605; pfam07717
688245006053 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
688245006054 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10632
688245006055 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245006056 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
688245006057 putative effector binding pocket; other site
688245006058 putative dimerization interface; other site
688245006059 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
688245006060 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245006061 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
688245006062 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
688245006063 NodT family; Region: outer_NodT; TIGR01845
688245006064 Outer membrane efflux protein; Region: OEP; pfam02321
688245006065 Outer membrane efflux protein; Region: OEP; pfam02321
688245006066 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
688245006067 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
688245006068 Beta-Casp domain; Region: Beta-Casp; pfam10996
688245006069 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
688245006070 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314
688245006071 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245006072 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
688245006073 SelB subfamily. SelB is an elongation factor needed for the co-translational incorporation of selenocysteine. Selenocysteine is coded by a UGA stop codon in combination with a specific downstream mRNA hairpin. In bacteria, the C-terminal part of...; Region: SelB; cd04171
688245006074 G1 box; other site
688245006075 putative GEF interaction site; other site
688245006076 GTP/Mg2+ binding site; other site
688245006077 Switch I region; other site
688245006078 G2 box; other site
688245006079 G3 box; other site
688245006080 Switch II region; other site
688245006081 G4 box; other site
688245006082 G5 box; other site
688245006083 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires...; Region: selB_II; cd03696
688245006084 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements...; Region: selB_III; cd04094
688245006085 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
688245006086 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
688245006087 selenocysteine synthase; Provisional; Region: PRK04311
688245006088 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
688245006089 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
688245006090 pyridoxal 5'-phosphate binding pocket; other site
688245006091 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
688245006092 catalytic residue; other site
688245006093 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564; cl11689
688245006094 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
688245006095 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
688245006096 Fe-S containing; Region: FDH-beta; TIGR01582
688245006097 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
688245006098 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928
688245006099 molybdopterin cofactor binding site; other site
688245006100 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928
688245006101 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
688245006102 molybdopterin cofactor binding site; other site
688245006103 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928
688245006104 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
688245006105 Domain of unknown function DUF20; Region: UPF0118; cl00465
688245006106 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
688245006107 TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016
688245006108 TPP-binding site; other site
688245006109 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
688245006110 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
688245006111 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
688245006112 E3 interaction surface; other site
688245006113 lipoyl attachment site; other site
688245006114 e3 binding domain; Region: E3_binding; pfam02817
688245006115 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
688245006116 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
688245006117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245006118 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
688245006119 Predicted ATPase [General function prediction only]; Region: COG1485
688245006120 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
688245006121 active site
688245006122 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
688245006123 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl12029
688245006124 helicase superfamily c-terminal domain; Region: HELICc2; cl09250
688245006125 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
688245006126 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
688245006127 DNA polymerase alpha chain like domain; Region: POLIIIAc; cl02625
688245006128 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
688245006129 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485
688245006130 generic binding surface II; other site
688245006131 generic binding surface I; other site
688245006132 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
688245006133 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
688245006134 Clp amino terminal domain; Region: Clp_N; pfam02861
688245006135 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245006136 Walker A motif; other site
688245006137 ATP binding site; other site
688245006138 Walker B motif; other site
688245006139 arginine finger; other site
688245006140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245006141 Walker A motif; other site
688245006142 ATP binding site; other site
688245006143 Walker B motif; other site
688245006144 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
688245006145 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
688245006146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245006147 active site
688245006148 phosphorylation site
688245006149 intermolecular recognition site; other site
688245006150 dimerization interface; other site
688245006151 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
688245006152 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
688245006153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245006154 ATP binding site; other site
688245006155 Mg2+ binding site; other site
688245006156 G-X-G motif; other site
688245006157 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
688245006158 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
688245006159 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
688245006160 Subunit I/III interface; other site
688245006161 Subunit III/IV interface; other site
688245006162 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
688245006163 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
688245006164 D-pathway; other site
688245006165 Putative ubiquinol binding site; other site
688245006166 Low-spin heme (heme b) binding site; other site
688245006167 Putative water exit pathway; other site
688245006168 Binuclear center (heme o3/CuB); other site
688245006169 K-pathway; other site
688245006170 Putative proton exit pathway; other site
688245006171 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
688245006172 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl10078
688245006173 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
688245006174 metabolite-proton symporter; Region: 2A0106; TIGR00883
688245006175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245006176 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245006177 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245006178 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245006179 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
688245006180 putative dimerization interface; other site
688245006181 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
688245006182 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245006183 Bacterial transcriptional regulator; Region: IclR; pfam01614
688245006184 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245006185 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
688245006186 Uncharacterized protein conserved in bacteria (DUF2257); Region: DUF2257; cl01794
688245006187 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
688245006188 Ligand Binding Site; other site
688245006189 hypothetical protein; Provisional; Region: PRK00808
688245006190 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl11605
688245006191 octamerization interface; other site
688245006192 diferric-oxygen binding site; other site
688245006193 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245006194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245006195 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
688245006196 Q-loop/lid; other site
688245006197 ABC transporter signature motif; other site
688245006198 Walker B; other site
688245006199 D-loop; other site
688245006200 H-loop/switch region; other site
688245006201 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
688245006202 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219
688245006203 Walker A/P-loop; other site
688245006204 ATP binding site; other site
688245006205 Q-loop/lid; other site
688245006206 ABC transporter signature motif; other site
688245006207 Walker B; other site
688245006208 D-loop; other site
688245006209 H-loop/switch region; other site
688245006210 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
688245006211 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
688245006212 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
688245006213 TM-ABC transporter signature motif; other site
688245006214 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
688245006215 TM-ABC transporter signature motif; other site
688245006216 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
688245006217 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
688245006218 dimerization interface; other site
688245006219 ligand binding site; other site
688245006220 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
688245006221 active site
688245006222 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
688245006223 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
688245006224 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans...; Region: HisKA; cd00082
688245006225 dimer interface; other site
688245006226 phosphorylation site
688245006227 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245006228 ATP binding site; other site
688245006229 Mg2+ binding site; other site
688245006230 G-X-G motif; other site
688245006231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245006232 active site
688245006233 phosphorylation site
688245006234 intermolecular recognition site; other site
688245006235 dimerization interface; other site
688245006236 glycine dehydrogenase; Provisional; Region: PRK05367
688245006237 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
688245006238 pyridoxal 5'-phosphate binding pocket; other site
688245006239 catalytic residue; other site
688245006240 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613
688245006241 tetramer interface; other site
688245006242 pyridoxal 5'-phosphate binding site; other site
688245006243 catalytic residue; other site
688245006244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884
688245006245 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L...; Region: GCS_H; cd06848
688245006246 lipoyl attachment site; other site
688245006247 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
688245006248 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
688245006249 Gram-negative bacterial tonB protein; Region: TonB; cl10048
688245006250 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
688245006251 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
688245006252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245006253 putative substrate translocation pore; other site
688245006254 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
688245006255 NodT family; Region: outer_NodT; TIGR01845
688245006256 Outer membrane efflux protein; Region: OEP; pfam02321
688245006257 Transcriptional regulators [Transcription]; Region: MarR; COG1846
688245006258 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245006259 Copper resistance protein D; Region: CopD; cl00563
688245006260 Catalase (peroxidase I) [Inorganic ion transport and metabolism]; Region: KatG; COG0376
688245006261 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
688245006262 dimer interface; other site
688245006263 active site
688245006264 heme binding site; other site
688245006265 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
688245006266 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
688245006267 PAS domain S-box; Region: sensory_box; TIGR00229
688245006268 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
688245006269 DNA binding residues
688245006270 dimerization interface; other site
688245006271 Coenzyme A transferase; Region: CoA_trans; cl00773
688245006272 Coenzyme A transferase; Region: CoA_trans; cl00773
688245006273 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
688245006274 Zn2+ binding site; other site
688245006275 Mg2+ binding site; other site
688245006276 Cell division inhibitor SulA; Region: SulA; cl01880
688245006277 DNA Polymerase Y-family; Region: Pol_Y_like; cd03468
688245006278 DNA binding site
688245006279 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
688245006280 DNA polymerase alpha chain like domain; Region: POLIIIAc; cl02625
688245006281 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
688245006282 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
688245006283 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485
688245006284 generic binding surface II; other site
688245006285 generic binding surface I; other site
688245006286 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
688245006287 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245006288 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
688245006289 dimerization interface; other site
688245006290 substrate binding pocket; other site
688245006291 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245006292 CoA-transferase family III; Region: CoA_transf_3; cl00778
688245006293 CoA-transferase family III; Region: CoA_transf_3; cl00778
688245006294 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
688245006295 active site 2
688245006296 active site 1
688245006297 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245006298 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
688245006299 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245006300 active site
688245006301 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245006302 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
688245006303 enoyl-CoA hydratase; Provisional; Region: PRK05980
688245006304 substrate binding site; other site
688245006305 oxyanion hole (OAH) forming residues; other site
688245006306 trimer interface; other site
688245006307 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
688245006308 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
688245006309 dimerization interface; other site
688245006310 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
688245006311 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144
688245006312 agmatine deiminase; Region: agmatine_aguA; TIGR03380
688245006313 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113
688245006314 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113
688245006315 agmatine deiminase; Region: agmatine_aguA; TIGR03380
688245006316 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
688245006317 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245006318 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245006319 dimerization interface; other site
688245006320 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
688245006321 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245006322 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245006323 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
688245006324 dimerization interface; other site
688245006325 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
688245006326 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245006327 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
688245006328 PSRA_1: Pseudouridine synthase, a subgroup of the RluA family. This group is comprised of bacterial proteins assigned to the RluA family of pseudouridine synthases. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PSRA_1; cd02558
688245006329 probable active site; other site
688245006330 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
688245006331 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
688245006332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245006333 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
688245006334 putative substrate translocation pore; other site
688245006335 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
688245006336 NodT family; Region: outer_NodT; TIGR01845
688245006337 Outer membrane efflux protein; Region: OEP; pfam02321
688245006338 Outer membrane efflux protein; Region: OEP; pfam02321
688245006339 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364
688245006340 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364
688245006341 Domain of unknown function (DUF1963); Region: DUF1963; cl01600
688245006342 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
688245006343 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
688245006344 catalytic triad; other site
688245006345 K+ potassium transporter; Region: K_trans; cl01227
688245006346 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
688245006347 VRR-NUC domain; Region: VRR_NUC; pfam08774
688245006348 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
688245006349 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl12029
688245006350 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
688245006351 helicase superfamily c-terminal domain; Region: HELICc2; cl09250
688245006352 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
688245006353 Uncharacterized protein family UPF0066; Region: UPF0066; cl00749
688245006354 TOBE domain; Region: TOBE_2; cl01440
688245006355 TOBE domain; Region: TOBE_2; cl01440
688245006356 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
688245006357 Coenzyme A binding pocket; other site
688245006358 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00443
688245006359 Protein of unknown function (DUF1232); Region: DUF1232; cl01318
688245006360 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
688245006361 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245006362 Walker A/P-loop; other site
688245006363 ATP binding site; other site
688245006364 ABC transporter signature motif; other site
688245006365 Walker B; other site
688245006366 D-loop; other site
688245006367 H-loop/switch region; other site
688245006368 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
688245006369 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
688245006370 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245006371 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
688245006372 dimerization interface; other site
688245006373 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
688245006374 active site
688245006375 metal-binding site
688245006376 Protein of unknown function DUF2625; Region: DUF2625; cl08177
688245006377 Protein of unknown function (DUF1697); Region: DUF1697; cl01557
688245006378 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928
688245006379 molybdopterin cofactor binding site; other site
688245006380 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928
688245006381 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
688245006382 putative molybdopterin cofactor binding site; other site
688245006383 Polysulphide reductase, NrfD; Region: NrfD; pfam03916
688245006384 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
688245006385 4Fe-4S binding domain; Region: Fer4; pfam00037
688245006386 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
688245006387 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738
688245006388 quinone interaction residues; other site
688245006389 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167
688245006390 active site
688245006391 catalytic residues; other site
688245006392 FMN binding site; other site
688245006393 substrate binding site; other site
688245006394 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
688245006395 tetramer (dimer of dimers) interface; other site
688245006396 active site
688245006397 dimer interface; other site
688245006398 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976
688245006399 catalytic residues; other site
688245006400 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
688245006401 Peptidase family M3 dipeptidyl carboxypeptidase (DCP; Dcp II; peptidyl dipeptidase; EC 3.4.15.5). This metal-binding M3A family also includes oligopeptidase A (OpdA; EC 3.4.24.70) enzyme. DCP cleaves dipeptides off the C-termini of various peptides and...; Region: M3A_DCP_Oligopeptidase_A; cd06456
688245006402 active site
688245006403 zinc binding site; other site
688245006404 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189
688245006405 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
688245006406 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
688245006407 homodimer interface; other site
688245006408 NADP binding site; other site
688245006409 substrate binding site; other site
688245006410 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
688245006411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245006412 active site
688245006413 phosphorylation site
688245006414 intermolecular recognition site; other site
688245006415 dimerization interface; other site
688245006416 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
688245006417 DNA binding residues
688245006418 dimerization interface; other site
688245006419 PAS domain S-box; Region: sensory_box; TIGR00229
688245006420 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
688245006421 putative active site; other site
688245006422 heme pocket; other site
688245006423 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080
688245006424 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245006425 ATP binding site; other site
688245006426 Mg2+ binding site; other site
688245006427 G-X-G motif; other site
688245006428 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
688245006429 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
688245006430 dimer interface; other site
688245006431 TPP-binding site; other site
688245006432 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
688245006433 E3 interaction surface; other site
688245006434 lipoyl attachment site; other site
688245006435 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508
688245006436 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
688245006437 E3 interaction surface; other site
688245006438 lipoyl attachment site; other site
688245006439 e3 binding domain; Region: E3_binding; pfam02817
688245006440 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
688245006441 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
688245006442 E3 interaction surface; other site
688245006443 lipoyl attachment site; other site
688245006444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245006445 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
688245006446 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
688245006447 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
688245006448 non-specific DNA binding site; other site
688245006449 salt bridge; other site
688245006450 sequence-specific DNA binding site; other site
688245006451 HipA N-terminal domain; Region: couple_hipA; TIGR03071
688245006452 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
688245006453 HipA-like N-terminal domain; Region: HipA_N; pfam07805
688245006454 HipA-like C-terminal domain; Region: HipA_C; pfam07804
688245006455 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
688245006456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245006457 d-galactonate transporter; Region: 2A0114; TIGR00893
688245006458 putative substrate translocation pore; other site
688245006459 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
688245006460 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
688245006461 PhnA protein; Region: PhnA; pfam03831
688245006462 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
688245006463 MoxR-like ATPases [General function prediction only]; Region: COG0714
688245006464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245006465 Walker A motif; other site
688245006466 ATP binding site; other site
688245006467 Walker B motif; other site
688245006468 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245006469 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245006470 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245006471 dimerization interface; other site
688245006472 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299
688245006473 Peptidase dimerization domain; Region: M20_dimer; cl09126
688245006474 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
688245006475 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
688245006476 uncharacterized enzyme; Region: gshA_cyan_rel; TIGR02050
688245006477 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245006478 metal-binding site
688245006479 active site
688245006480 I-site; other site
688245006481 Protein of unknown function (DUF2167); Region: DUF2167; cl01938
688245006482 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
688245006483 active site
688245006484 catalytic tetrad; other site
688245006485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245006486 putative substrate translocation pore; other site
688245006487 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
688245006488 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
688245006489 active site
688245006490 Predicted membrane protein [Function unknown]; Region: COG4129
688245006491 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
688245006492 ethanolamine permease; Region: 2A0305; TIGR00908
688245006493 Protein of unknown function DUF55; Region: DUF55; cl00728
688245006494 Transglycosylase associated protein; Region: Transgly_assoc; cl00978
688245006495 NlpC/P60 family; Region: NLPC_P60; cl11438
688245006496 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012
688245006497 Isochorismatase family; Region: Isochorismatase; pfam00857
688245006498 catalytic triad; other site
688245006499 dimer interface; other site
688245006500 conserved cis-peptide bond; other site
688245006501 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
688245006502 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
688245006503 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245006504 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
688245006505 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
688245006506 active site
688245006507 substrate binding site; other site
688245006508 metal-binding site
688245006509 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
688245006510 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
688245006511 outer membrane channel protein; Reviewed; Region: tolC; PRK09465
688245006512 Outer membrane efflux protein; Region: OEP; pfam02321
688245006513 Outer membrane efflux protein; Region: OEP; pfam02321
688245006514 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
688245006515 active site residue
688245006516 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
688245006517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
688245006518 S-adenosylmethionine binding site; other site
688245006519 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
688245006520 Protein export membrane protein; Region: SecD_SecF; cl14618
688245006521 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
688245006522 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
688245006523 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
688245006524 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245006525 N-terminal plug; other site
688245006526 ligand-binding site; other site
688245006527 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
688245006528 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182
688245006529 DNA binding site
688245006530 Int/Topo IB signature motif; other site
688245006531 active site
688245006532 catalytic residues; other site
688245006533 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
688245006534 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
688245006535 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590
688245006536 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
688245006537 Ligand binding site; other site
688245006538 metal-binding site
688245006539 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
688245006540 E-class dimer interface; other site
688245006541 P-class dimer interface; other site
688245006542 active site
688245006543 Cu2+ binding site; other site
688245006544 Zn2+ binding site; other site
688245006545 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
688245006546 putative active site pocket; other site
688245006547 dimerization interface; other site
688245006548 putative catalytic residue; other site
688245006549 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
688245006550 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
688245006551 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245006552 putative acyl-CoA synthetase; Provisional; Region: PRK06018
688245006553 enoyl-CoA hydratase; Provisional; Region: PRK05980
688245006554 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
688245006555 substrate binding site; other site
688245006556 oxyanion hole (OAH) forming residues; other site
688245006557 trimer interface; other site
688245006558 Protein of unknown function, DUF485; Region: DUF485; cl01231
688245006559 Sodium:solute symporter family; Region: SSF; cl00456
688245006560 Predicted symporter [General function prediction only]; Region: DhlC; COG4147
688245006561 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
688245006562 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245006563 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
688245006564 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
688245006565 tetrameric interface; other site
688245006566 NAD binding site; other site
688245006567 catalytic residues; other site
688245006568 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
688245006569 dimer interface; other site
688245006570 active site
688245006571 glutathione binding site; other site
688245006572 metal-binding site
688245006573 putative replication initiation protein; Region: PHA00330
688245006574 Zonular occludens toxin (Zot); Region: Zot; cl01706
688245006575 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245006576 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
688245006577 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245006578 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245006579 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
688245006580 putative dimerization interface; other site
688245006581 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688245006582 pyridoxal 5'-phosphate binding site; other site
688245006583 homodimer interface; other site
688245006584 catalytic residue; other site
688245006585 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802
688245006586 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
688245006587 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688245006588 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688245006589 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
688245006590 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
688245006591 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
688245006592 Phage integrase family; Region: Phage_integrase; pfam00589
688245006593 DNA binding site
688245006594 Int/Topo IB signature motif; other site
688245006595 active site
688245006596 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
688245006597 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245006598 substrate binding pocket; other site
688245006599 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488
688245006600 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
688245006601 dimer interface; other site
688245006602 substrate binding site; other site
688245006603 metal-binding site
688245006604 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
688245006605 putative active site; other site
688245006606 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
688245006607 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
688245006608 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
688245006609 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
688245006610 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850
688245006611 carboxyltransferase (CT) interaction site; other site
688245006612 biotinylation site; other site
688245006613 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
688245006614 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513
688245006615 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513
688245006616 arginine/ornithine transport system ATPase; Provisional; Region: PRK09435
688245006617 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
688245006618 Walker A; other site
688245006619 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
688245006620 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily...; Region: MM_CoA_mutase_alpha_like; cd03679
688245006621 active site
688245006622 substrate binding site; other site
688245006623 coenzyme B12 binding site; other site
688245006624 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen...; Region: MM_CoA_mut_B12_BD; cd02071
688245006625 B12 binding site; other site
688245006626 cobalt ligand; other site
688245006627 Transcriptional regulators [Transcription]; Region: GntR; COG1802
688245006628 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245006629 DNA binding site
688245006630 FCD domain; Region: FCD; cl11656
688245006631 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
688245006632 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
688245006633 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
688245006634 PAS domain S-box; Region: sensory_box; TIGR00229
688245006635 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
688245006636 putative active site; other site
688245006637 heme pocket; other site
688245006638 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
688245006639 PAS fold; Region: PAS_4; pfam08448
688245006640 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
688245006641 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245006642 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245006643 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
688245006644 Cache domain; Region: Cache_1; pfam02743
688245006645 insertion element IS2 transposase InsD; Reviewed; Region: PRK09409
688245006646 Integrase core domain; Region: rve; cl01316
688245006647 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
688245006648 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245006649 metal-binding site
688245006650 active site
688245006651 I-site; other site
688245006652 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801
688245006653 Dihydrouridine synthase (Dus); Region: Dus; pfam01207
688245006654 FMN binding site; other site
688245006655 active site
688245006656 catalytic residues; other site
688245006657 substrate binding site; other site
688245006658 potential frameshift: common BLAST hit: gi|160899057|ref|YP_001564639.1| polyhydroxyalkanoate depolymerase, intracellular
688245006659 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
688245006660 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245006661 ferredoxin; Provisional; Region: PRK06991
688245006662 Putative Fe-S cluster; Region: FeS; pfam04060
688245006663 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
688245006664 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144
688245006665 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
688245006666 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688245006667 putative aminotransferase; Validated; Region: PRK09082
688245006668 pyridoxal 5'-phosphate binding site; other site
688245006669 homodimer interface; other site
688245006670 catalytic residue; other site
688245006671 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
688245006672 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA...; Region: LbH_THP_succinylT; cd03350
688245006673 active site
688245006674 substrate binding site; other site
688245006675 trimer interface; other site
688245006676 CoA binding site; other site
688245006677 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
688245006678 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245006679 Walker A motif; other site
688245006680 ATP binding site; other site
688245006681 Walker B motif; other site
688245006682 succinyl-diaminopimelate desuccinylase, proteobacterial clade; Region: dapE_proteo; TIGR01246
688245006683 Peptidase dimerization domain; Region: M20_dimer; cl09126
688245006684 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
688245006685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
688245006686 S-adenosylmethionine binding site; other site
688245006687 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
688245006688 dinuclear metal binding motif; other site
688245006689 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
688245006690 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245006691 Walker A/P-loop; other site
688245006692 ATP binding site; other site
688245006693 Q-loop/lid; other site
688245006694 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
688245006695 ABC transporter signature motif; other site
688245006696 Walker B; other site
688245006697 D-loop; other site
688245006698 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
688245006699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245006700 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
688245006701 acetyl-CoA acetyltransferase; Provisional; Region: PRK05790
688245006702 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
688245006703 dimer interface; other site
688245006704 active site
688245006705 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
688245006706 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
688245006707 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245006708 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
688245006709 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
688245006710 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Zeta; cd03042
688245006711 maleylacetoacetate isomerase; Region: maiA; TIGR01262
688245006712 C-terminal domain interface; other site
688245006713 GSH binding site (G-site); other site
688245006714 putative dimer interface; other site
688245006715 GST_C family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_C_Zeta; cd03191
688245006716 dimer interface; other site
688245006717 N-terminal domain interface; other site
688245006718 putative maleylacetoacetate (MAA) substrate binding site (H site); other site
688245006719 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
688245006720 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
688245006721 nudix motif; other site
688245006722 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
688245006723 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
688245006724 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245006725 metal-binding site
688245006726 active site
688245006727 I-site; other site
688245006728 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
688245006729 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
688245006730 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
688245006731 FAD-dependent oxidoreductase; Provisional; Region: PRK08132
688245006732 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245006733 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245006734 Uncharacterized conserved protein [Function unknown]; Region: COG1739
688245006735 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
688245006736 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
688245006737 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245006738 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
688245006739 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245006740 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245006741 dimerization interface; other site
688245006742 LysE type translocator; Region: LysE; cl00565
688245006743 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
688245006744 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
688245006745 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
688245006746 YceI-like domain; Region: YceI; cl01001
688245006747 YceI-like domain; Region: YceI; cl01001
688245006748 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; cl10449
688245006749 hypothetical protein; Reviewed; Region: PRK09588
688245006750 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032
688245006751 Protein of unknown function, DUF393; Region: DUF393; cl01136
688245006752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245006753 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
688245006754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245006755 active site
688245006756 phosphorylation site
688245006757 intermolecular recognition site; other site
688245006758 dimerization interface; other site
688245006759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245006760 Walker A motif; other site
688245006761 ATP binding site; other site
688245006762 Walker B motif; other site
688245006763 arginine finger; other site
688245006764 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
688245006765 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
688245006766 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080
688245006767 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245006768 ATP binding site; other site
688245006769 Mg2+ binding site; other site
688245006770 G-X-G motif; other site
688245006771 Sodium:dicarboxylate symporter family; Region: SDF; cl00573
688245006772 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586
688245006773 active site
688245006774 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
688245006775 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245006776 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
688245006777 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
688245006778 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG2984
688245006779 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
688245006780 zinc binding site; other site
688245006781 putative ligand binding site; other site
688245006782 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
688245006783 TM-ABC transporter signature motif; other site
688245006784 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
688245006785 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245006786 Walker A/P-loop; other site
688245006787 ATP binding site; other site
688245006788 Q-loop/lid; other site
688245006789 ABC transporter signature motif; other site
688245006790 Walker B; other site
688245006791 D-loop; other site
688245006792 H-loop/switch region; other site
688245006793 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
688245006794 Amino acid permease; Region: AA_permease; pfam00324
688245006795 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
688245006796 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
688245006797 Permease family; Region: Xan_ur_permease; cl00967
688245006798 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
688245006799 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245006800 metal-binding site
688245006801 active site
688245006802 I-site; other site
688245006803 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
688245006804 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a...; Region: MinD; cd02036
688245006805 P-loop; other site
688245006806 ADP binding residues; other site
688245006807 Switch I; other site
688245006808 Switch II; other site
688245006809 rhodanese superfamily protein; Provisional; Region: PRK05320
688245006810 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
688245006811 active site residue
688245006812 NADPH-dependent FMN reductase; Region: FMN_red; cl00438
688245006813 DoxX; Region: DoxX; cl00976
688245006814 Cupin domain; Region: Cupin_2; cl09118
688245006815 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245006816 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245006817 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245006818 dimerization interface; other site
688245006819 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245006820 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
688245006821 HIGH motif; other site
688245006822 active site
688245006823 nucleotide binding site; other site
688245006824 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
688245006825 KMSKS motif; other site
688245006826 active site
688245006827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245006828 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
688245006829 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673
688245006830 active site
688245006831 motif 2; other site
688245006832 motif 3; other site
688245006833 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
688245006834 SmpB protein; Region: SmpB; cl00482
688245006835 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; cl10449
688245006836 Uncharacterized protein family (UPF0125); Region: UPF0125; cl01096
688245006837 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
688245006838 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
688245006839 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
688245006840 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381
688245006841 active site
688245006842 Phd_YefM; Region: PhdYeFM; cl09153
688245006843 PIN domain; Region: PIN; cl09128
688245006844 GMP synthase; Reviewed; Region: guaA; PRK00074
688245006845 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
688245006846 AMP/PPi binding site; other site
688245006847 candidate oxyanion hole; other site
688245006848 catalytic triad; other site
688245006849 potential glutamine specificity residues; other site
688245006850 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
688245006851 ATP Binding subdomain; other site
688245006852 Ligand Binding sites; other site
688245006853 Dimerization subdomain; other site
688245006854 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245006855 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245006856 Subunit B of the Class III extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of protocatechuate; Region: PCA_45_Dioxygenase_B; cd07364
688245006857 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
688245006858 active site
688245006859 Fe(II) binding site; other site
688245006860 dimer interface; other site
688245006861 tetramer interface; other site
688245006862 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673
688245006863 dimer interface; other site
688245006864 tetramer interface; other site
688245006865 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
688245006866 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245006867 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791
688245006868 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245006869 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245006870 dimerization interface; other site
688245006871 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454
688245006872 apolar tunnel; other site
688245006873 heme binding site; other site
688245006874 dimerization interface; other site
688245006875 NnrS protein; Region: NnrS; cl01258
688245006876 Predicted transcriptional regulator [Transcription]; Region: COG1959
688245006877 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245006878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399
688245006879 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cd00322
688245006880 FAD binding pocket; other site
688245006881 conserved FAD binding motif; other site
688245006882 phosphate binding motif; other site
688245006883 beta-alpha-beta structure motif; other site
688245006884 NAD binding pocket; other site
688245006885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4694
688245006886 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245006887 Phage portal protein; Region: Phage_portal; cl01923
688245006888 terminase ATPase subunit; Provisional; Region: P; PHA02535
688245006889 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
688245006890 DNA binding site
688245006891 Int/Topo IB signature motif; other site
688245006892 active site
688245006893 Transposase DDE domain; Region: Transposase_11; pfam01609
688245006894 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
688245006895 synthetase active site; other site
688245006896 NTP binding site; other site
688245006897 metal-binding site
688245006898 integron integrase; Region: integrase_gron; TIGR02249
688245006899 DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and a secondary target called the attC (or 59-base element)...; Region: INT_IntI; cd01193
688245006900 Int/Topo IB signature motif; other site
688245006901 conserved hypothetical protein TIGR02646; Region: TIGR02646
688245006902 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267
688245006903 Q-loop/lid; other site
688245006904 ABC transporter signature motif; other site
688245006905 Walker B; other site
688245006906 D-loop; other site
688245006907 H-loop/switch region; other site
688245006908 haemagglutination activity domain; Region: Haemagg_act; cl05436
688245006909 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
688245006910 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
688245006911 Surface antigen; Region: Bac_surface_Ag; cl03097
688245006912 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763
688245006913 short chain dehydrogenase; Provisional; Region: PRK06123
688245006914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245006915 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
688245006916 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
688245006917 FAD binding pocket; other site
688245006918 FAD binding motif; other site
688245006919 phosphate binding motif; other site
688245006920 NAD binding pocket; other site
688245006921 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
688245006922 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
688245006923 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
688245006924 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245006925 N-terminal plug; other site
688245006926 ligand-binding site; other site
688245006927 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
688245006928 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
688245006929 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245006930 Walker A motif; other site
688245006931 ATP binding site; other site
688245006932 Walker B motif; other site
688245006933 arginine finger; other site
688245006934 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
688245006935 Integrase core domain; Region: rve; cl01316
688245006936 potential frameshift: common BLAST hit: gi|168998487|ref|YP_001687757.1| transposase, IS4 family protein
688245006937 Transposase DDE domain; Region: Transposase_11; pfam01609
688245006938 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
688245006939 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
688245006940 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
688245006941 DNA binding residues
688245006942 dimer interface; other site
688245006943 putative metal binding site; other site
688245006944 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
688245006945 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
688245006946 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
688245006947 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480
688245006948 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
688245006949 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
688245006950 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
688245006951 Bacitracin resistance protein BacA; Region: BacA; cl00858
688245006952 Cytochrome c; Region: Cytochrom_C; cl11414
688245006953 Iron permease FTR1 family; Region: FTR1; cl00475
688245006954 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
688245006955 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
688245006956 Sulfatase; Region: Sulfatase; cl10460
688245006957 heavy metal efflux pump (cobalt-zinc-cadmium); Region: 2A0601; TIGR00914
688245006958 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
688245006959 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
688245006960 Outer membrane efflux protein; Region: OEP; pfam02321
688245006961 Outer membrane efflux protein; Region: OEP; pfam02321
688245006962 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
688245006963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245006964 active site
688245006965 phosphorylation site
688245006966 intermolecular recognition site; other site
688245006967 dimerization interface; other site
688245006968 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
688245006969 DNA binding site
688245006970 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
688245006971 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
688245006972 dimer interface; other site
688245006973 phosphorylation site
688245006974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245006975 ATP binding site; other site
688245006976 Mg2+ binding site; other site
688245006977 G-X-G motif; other site
688245006978 potential frameshift: common BLAST hit: gi|160898113|ref|YP_001563695.1| integrase catalytic region
688245006979 Integrase core domain; Region: rve; cl01316
688245006980 Domain of unknown function DUF; Region: DUF204; pfam02659
688245006981 Domain of unknown function DUF; Region: DUF204; pfam02659
688245006982 insertion element IS2 transposase InsD; Reviewed; Region: PRK09409
688245006983 Integrase core domain; Region: rve; cl01316
688245006984 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
688245006985 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526
688245006986 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
688245006987 active site
688245006988 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl09471
688245006989 potential frameshift: common BLAST hit: gi|121593734|ref|YP_985630.1| heavy metal translocating P-type ATPase
688245006990 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
688245006991 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
688245006992 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
688245006993 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
688245006994 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
688245006995 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
688245006996 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
688245006997 DNA binding residues
688245006998 Sulfatase; Region: Sulfatase; cl10460
688245006999 potential frameshift: common BLAST hit: gi|91788706|ref|YP_549658.1| transposase IS116/IS110/IS902
688245007000 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
688245007001 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363
688245007002 heavy metal efflux pump (cobalt-zinc-cadmium); Region: 2A0601; TIGR00914
688245007003 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
688245007004 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363
688245007005 Outer membrane efflux protein; Region: OEP; pfam02321
688245007006 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
688245007007 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
688245007008 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
688245007009 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
688245007010 dimer interface; other site
688245007011 phosphorylation site
688245007012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245007013 ATP binding site; other site
688245007014 Mg2+ binding site; other site
688245007015 G-X-G motif; other site
688245007016 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
688245007017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245007018 active site
688245007019 phosphorylation site
688245007020 intermolecular recognition site; other site
688245007021 dimerization interface; other site
688245007022 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
688245007023 DNA binding site
688245007024 Multicopper oxidase; Region: Cu-oxidase; cl11412
688245007025 Multicopper oxidase; Region: Cu-oxidase; cl11412
688245007026 Multicopper oxidase; Region: Cu-oxidase; cl11412
688245007027 Copper resistance protein B precursor (CopB); Region: CopB; cl01476
688245007028 Copper resistance protein CopC; Region: CopC; cl01012
688245007029 Copper resistance protein D; Region: CopD; cl00563
688245007030 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
688245007031 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
688245007032 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
688245007033 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
688245007034 Low molecular weight phosphatase family; Region: LMWPc; cd00115
688245007035 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
688245007036 active site
688245007037 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
688245007038 transmembrane helices; other site
688245007039 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
688245007040 catalytic residues; other site
688245007041 NADPH-dependent FMN reductase; Region: FMN_red; cl00438
688245007042 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292
688245007043 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
688245007044 Ligand Binding Site; other site
688245007045 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
688245007046 Permease family; Region: Xan_ur_permease; cl00967
688245007047 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
688245007048 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
688245007049 multiple promoter invertase; Provisional; Region: mpi; PRK13413
688245007050 catalytic residues; other site
688245007051 catalytic nucleophile; other site
688245007052 Presynaptic Site I dimer interface; other site
688245007053 Synaptic Antiparallel dimer interface; other site
688245007054 Synaptic Flat tetramer interface; other site
688245007055 Synaptic Site I dimer interface; other site
688245007056 DNA binding site
688245007057 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
688245007058 DNA-binding interface; DNA binding site
688245007059 Transposase; Region: Transposase_7; pfam01526
688245007060 Transposase and inactivated derivatives, TnpA family [DNA replication, recombination, and repair]; Region: COG4644
688245007061 Transposase and inactivated derivatives, TnpA family [DNA replication, recombination, and repair]; Region: COG4644
688245007062 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
688245007063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245007064 Walker A motif; other site
688245007065 ATP binding site; other site
688245007066 Walker B motif; other site
688245007067 arginine finger; other site
688245007068 potential frameshift: common BLAST hit: gi|58616638|ref|YP_195847.1| transposase
688245007069 methyl-accepting protein IV; Provisional; Region: PRK09793
688245007070 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
688245007071 putative active site; other site
688245007072 heme pocket; other site
688245007073 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
688245007074 Sensors of blue-light using FAD; Region: BLUF; pfam04940
688245007075 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
688245007076 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245007077 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245007078 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
688245007079 dimerization interface; other site
688245007080 allantoate amidohydrolase; Reviewed; Region: PRK12890
688245007081 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908
688245007082 putative ADP-ribose binding site; other site
688245007083 putative active site; other site
688245007084 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342
688245007085 trimer interface; other site
688245007086 eyelet of channel; other site
688245007087 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
688245007088 DinB family; Region: DinB; cl00986
688245007089 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
688245007090 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245007091 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
688245007092 DNA binding site
688245007093 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688245007094 pyridoxal 5'-phosphate binding site; other site
688245007095 homodimer interface; other site
688245007096 catalytic residue; other site
688245007097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245007098 putative substrate translocation pore; other site
688245007099 Beta-lactamase; Region: Beta-lactamase; cl01009
688245007100 potential frameshift: common BLAST hit: gi|226945638|ref|YP_002800711.1| Regulatory protein, LysR family
688245007101 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245007102 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245007103 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245007104 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245007105 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245007106 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245007107 dimerization interface; other site
688245007108 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245007109 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
688245007110 Protein of unknown function (DUF1232); Region: DUF1232; cl01318
688245007111 Major Facilitator Superfamily; Region: MFS_1; pfam07690
688245007112 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245007113 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245007114 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245007115 dimerization interface; other site
688245007116 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside...; Region: NK; cl11962
688245007117 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00443
688245007118 potential frameshift: common BLAST hit: gi|167034315|ref|YP_001669546.1| luciferase family protein
688245007119 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
688245007120 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
688245007121 glutathione S-transferase; Provisional; Region: PRK13972
688245007122 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048
688245007123 C-terminal domain interface; other site
688245007124 GSH binding site (G-site); other site
688245007125 dimer interface; other site
688245007126 GST_C family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_C_Ure2p_like; cd03178
688245007127 dimer interface; other site
688245007128 N-terminal domain interface; other site
688245007129 putative substrate binding pocket (H-site); other site
688245007130 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
688245007131 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245007132 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
688245007133 dimerization interface; other site
688245007134 substrate binding pocket; other site
688245007135 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
688245007136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245007137 active site
688245007138 phosphorylation site
688245007139 intermolecular recognition site; other site
688245007140 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
688245007141 DNA binding residues
688245007142 dimerization interface; other site
688245007143 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
688245007144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245007145 ATP binding site; other site
688245007146 Mg2+ binding site; other site
688245007147 G-X-G motif; other site
688245007148 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
688245007149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245007150 active site
688245007151 phosphorylation site
688245007152 intermolecular recognition site; other site
688245007153 dimerization interface; other site
688245007154 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
688245007155 DNA binding residues
688245007156 dimerization interface; other site
688245007157 Fimbrial protein; Region: Fimbrial; cl01416
688245007158 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
688245007159 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
688245007160 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
688245007161 Fimbrial Usher protein; Region: Usher; pfam00577
688245007162 Fimbrial protein; Region: Fimbrial; cl01416
688245007163 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
688245007164 Mannitol repressor; Region: MtlR; cl11450
688245007165 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259
688245007166 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
688245007167 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590
688245007168 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245007169 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245007170 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245007171 dimerization interface; other site
688245007172 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
688245007173 Coenzyme A binding pocket; other site
688245007174 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987
688245007175 Transposase DDE domain; Region: Transposase_11; pfam01609
688245007176 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
688245007177 homotrimer interaction site; other site
688245007178 putative active site; other site
688245007179 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
688245007180 CorA-like Mg2+ transporter protein; Region: CorA; cl00459
688245007181 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245007182 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245007183 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
688245007184 putative effector binding pocket; other site
688245007185 putative dimerization interface; other site
688245007186 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
688245007187 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245007188 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
688245007189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245007190 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
688245007191 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
688245007192 putative active site; other site
688245007193 putative FMN binding site; other site
688245007194 putative substrate binding site; other site
688245007195 putative catalytic residue; other site
688245007196 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
688245007197 putative NAD(P) binding site; other site
688245007198 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
688245007199 NAD(P) binding site; other site
688245007200 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342
688245007201 trimer interface; other site
688245007202 eyelet of channel; other site
688245007203 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245007204 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
688245007205 Integrase core domain; Region: rve; cl01316
688245007206 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
688245007207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245007208 Walker A motif; other site
688245007209 ATP binding site; other site
688245007210 Walker B motif; other site
688245007211 arginine finger; other site
688245007212 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
688245007213 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
688245007214 substrate binding pocket; other site
688245007215 membrane-bound complex binding site; other site
688245007216 hinge residues; other site
688245007217 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841
688245007218 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
688245007219 dimer interface; other site
688245007220 phosphorylation site
688245007221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245007222 ATP binding site; other site
688245007223 Mg2+ binding site; other site
688245007224 G-X-G motif; other site
688245007225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245007226 active site
688245007227 phosphorylation site
688245007228 intermolecular recognition site; other site
688245007229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245007230 active site
688245007231 phosphorylation site
688245007232 intermolecular recognition site; other site
688245007233 dimerization interface; other site
688245007234 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
688245007235 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841
688245007236 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
688245007237 dimer interface; other site
688245007238 phosphorylation site
688245007239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245007240 ATP binding site; other site
688245007241 Mg2+ binding site; other site
688245007242 G-X-G motif; other site
688245007243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245007244 active site
688245007245 phosphorylation site
688245007246 intermolecular recognition site; other site
688245007247 dimerization interface; other site
688245007248 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
688245007249 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245007250 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
688245007251 Coenzyme A binding pocket; other site
688245007252 LysE type translocator; Region: LysE; cl00565
688245007253 EamA-like transporter family; Region: EamA; cl01037
688245007254 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245007255 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245007256 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
688245007257 dimerization interface; other site
688245007258 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
688245007259 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245007260 DNA binding site
688245007261 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688245007262 pyridoxal 5'-phosphate binding site; other site
688245007263 homodimer interface; other site
688245007264 catalytic residue; other site
688245007265 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
688245007266 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245007267 metal-binding site
688245007268 active site
688245007269 I-site; other site
688245007270 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
688245007271 conserved cys residue; other site
688245007272 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541
688245007273 Autoinducer binding domain; Region: Autoind_bind; pfam03472
688245007274 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
688245007275 DNA binding residues
688245007276 dimerization interface; other site
688245007277 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
688245007278 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
688245007279 Protein of unknown function, DUF606; Region: DUF606; cl01273
688245007280 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245007281 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245007282 The C-terminal substrate binding domain of LysR-type transcriptional regulator ToxR regulates the expression of the toxoflavin biosynthesis genes; contains the type 2 periplasmic bindinig fold; Region: PBP2_ToxR; cd08465
688245007283 putative substrate binding pocket; other site
688245007284 putative dimerization interface; other site
688245007285 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
688245007286 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00443
688245007287 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245007288 A new structural DNA glycosylase; Region: AlkD_like; cl11434
688245007289 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA...; Region: S24_LexA-like; cd06529
688245007290 Catalytic site; other site
688245007291 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
688245007292 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245007293 Q-loop/lid; other site
688245007294 ABC transporter signature motif; other site
688245007295 Walker B; other site
688245007296 D-loop; other site
688245007297 H-loop/switch region; other site
688245007298 Protein of unknown function (DUF1003); Region: DUF1003; cl01831
688245007299 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
688245007300 Ligand Binding Site; other site
688245007301 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
688245007302 Ligand Binding Site; other site
688245007303 Fimbrial protein; Region: Fimbrial; cl01416
688245007304 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245007305 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245007306 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
688245007307 dimerization interface; other site
688245007308 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00443
688245007309 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
688245007310 non-specific DNA binding site; other site
688245007311 salt bridge; other site
688245007312 sequence-specific DNA binding site; other site
688245007313 HipA-like N-terminal domain; Region: HipA_N; pfam07805
688245007314 HipA-like C-terminal domain; Region: HipA_C; pfam07804
688245007315 Fic/DOC family; Region: Fic; cl00960
688245007316 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
688245007317 Int/Topo IB signature motif; other site
688245007318 active site
688245007319 DNA binding site
688245007320 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
688245007321 Catalytic site; other site
688245007322 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590
688245007323 RNA/DNA binding site; other site
688245007324 RRM dimerization site; other site
688245007325 Uncharacterized ACR, COG2135; Region: DUF159; cl03646
688245007326 Predicted membrane protein [Function unknown]; Region: COG4129
688245007327 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
688245007328 Gas vesicle protein G; Region: GvpG; pfam05120
688245007329 Phage terminase large subunit; Region: Terminase_3; cl12054
688245007330 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
688245007331 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222
688245007332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
688245007333 S-adenosylmethionine binding site; other site
688245007334 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
688245007335 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356
688245007336 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
688245007337 Phage antirepressor protein KilAC domain; Region: ANT; cl01462
688245007338 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529
688245007339 Catalytic site; other site
688245007340 Putative exonuclease, RdgC; Region: RdgC; cl01122
688245007341 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
688245007342 Phage integrase family; Region: Phage_integrase; pfam00589
688245007343 DNA binding site
688245007344 Int/Topo IB signature motif; other site
688245007345 active site
688245007346 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl00696
688245007347 UbiA prenyltransferase family; Region: UbiA; cl00337
688245007348 Cytochrome c [Energy production and conversion]; Region: COG3258
688245007349 Cytochrome c; Region: Cytochrom_C; cl11414
688245007350 Cytochrome c; Region: Cytochrom_C; cl11414
688245007351 Cytochrome c; Region: Cytochrom_C; cl11414
688245007352 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
688245007353 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
688245007354 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
688245007355 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
688245007356 dimer interface; other site
688245007357 phosphorylation site
688245007358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245007359 ATP binding site; other site
688245007360 Mg2+ binding site; other site
688245007361 G-X-G motif; other site
688245007362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245007363 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
688245007364 active site
688245007365 phosphorylation site
688245007366 intermolecular recognition site; other site
688245007367 dimerization interface; other site
688245007368 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
688245007369 DNA binding site
688245007370 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
688245007371 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966
688245007372 catalytic residues; other site
688245007373 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
688245007374 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide...; Region: DsbA_DsbC_DsbG; cd03020
688245007375 dimer interface; other site
688245007376 catalytic residues; other site
688245007377 DsrE/DsrF-like family; Region: DrsE; cl00672
688245007378 hypothetical protein; Provisional; Region: PRK10279
688245007379 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
688245007380 active site
688245007381 nucleophile elbow; other site
688245007382 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
688245007383 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
688245007384 nucleotide binding pocket; other site
688245007385 K-X-D-G motif; other site
688245007386 catalytic site; other site
688245007387 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
688245007388 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
688245007389 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl11430
688245007390 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027
688245007391 Dimer interface; other site
688245007392 BRCT sequence motif; other site
688245007393 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
688245007394 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
688245007395 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278
688245007396 Walker A/P-loop; other site
688245007397 ATP binding site; other site
688245007398 Q-loop/lid; other site
688245007399 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278
688245007400 ABC transporter signature motif; other site
688245007401 Walker B; other site
688245007402 D-loop; other site
688245007403 H-loop/switch region; other site
688245007404 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757
688245007405 CHASE domain; Region: CHASE; cl01369
688245007406 PAS domain S-box; Region: sensory_box; TIGR00229
688245007407 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
688245007408 putative active site; other site
688245007409 heme pocket; other site
688245007410 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245007411 metal-binding site
688245007412 active site
688245007413 I-site; other site
688245007414 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
688245007415 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
688245007416 NADPH-dependent FMN reductase; Region: FMN_red; cl00438
688245007417 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
688245007418 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
688245007419 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
688245007420 Outer membrane efflux protein; Region: OEP; pfam02321
688245007421 Outer membrane efflux protein; Region: OEP; pfam02321
688245007422 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
688245007423 Protein export membrane protein; Region: SecD_SecF; cl14618
688245007424 multidrug efflux system protein MdtE; Provisional; Region: PRK09859
688245007425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245007426 putative substrate translocation pore; other site
688245007427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245007428 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
688245007429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245007430 putative substrate translocation pore; other site
688245007431 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
688245007432 hypothetical protein; Provisional; Region: PRK06194
688245007433 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245007434 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
688245007435 Prostaglandin dehydrogenases; Region: PGDH; cd05288
688245007436 NAD(P) binding site; other site
688245007437 substrate binding site; other site
688245007438 dimer interface; other site
688245007439 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
688245007440 CoenzymeA binding site; other site
688245007441 subunit interaction site; other site
688245007442 PHB binding site; other site
688245007443 gluconate 5-dehydrogenase; Provisional; Region: PRK08213
688245007444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245007445 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
688245007446 DNA binding site
688245007447 active site
688245007448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245007449 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245007450 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
688245007451 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
688245007452 nucleoside/Zn binding site; other site
688245007453 dimer interface; other site
688245007454 catalytic motif; other site
688245007455 putative cyanate transporter; Provisional; Region: cynX; PRK09705
688245007456 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
688245007457 Zn2+ binding site; other site
688245007458 UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: GlnD; COG2844
688245007459 Mg2+ binding site; other site
688245007460 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside...; Region: NK; cl11962
688245007461 The Adenylation domain of proteins from the ATP-dependent polynucleotide ligase family is the minimal catalytic unit that is common to all family members; Region: Adenylation_DNA_ligase_family; cl12015
688245007462 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
688245007463 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431
688245007464 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245007465 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
688245007466 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256
688245007467 Walker A/P-loop; other site
688245007468 ATP binding site; other site
688245007469 Q-loop/lid; other site
688245007470 ABC transporter signature motif; other site
688245007471 Walker B; other site
688245007472 D-loop; other site
688245007473 H-loop/switch region; other site
688245007474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
688245007475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
688245007476 Transcriptional regulators [Transcription]; Region: Lrp; COG1522
688245007477 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245007478 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
688245007479 Cytochrome c; Region: Cytochrom_C; cl11414
688245007480 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
688245007481 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
688245007482 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
688245007483 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
688245007484 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
688245007485 dimer interface; other site
688245007486 phosphorylation site
688245007487 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245007488 ATP binding site; other site
688245007489 Mg2+ binding site; other site
688245007490 G-X-G motif; other site
688245007491 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
688245007492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245007493 active site
688245007494 phosphorylation site
688245007495 intermolecular recognition site; other site
688245007496 dimerization interface; other site
688245007497 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
688245007498 DNA binding site
688245007499 SelR domain; Region: SelR; cl00369
688245007500 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515
688245007501 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
688245007502 catalytic residues; other site
688245007503 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
688245007504 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
688245007505 Proteobacterial; Region: dnaQ_proteo; TIGR01406
688245007506 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
688245007507 catalytic loop; other site
688245007508 iron binding site; other site
688245007509 chaperone protein HscA; Provisional; Region: hscA; PRK05183
688245007510 co-chaperone HscB; Provisional; Region: hscB; PRK03578
688245007511 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542
688245007512 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
688245007513 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
688245007514 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
688245007515 trimerization site; other site
688245007516 active site
688245007517 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
688245007518 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
688245007519 pyridoxal 5'-phosphate binding pocket; other site
688245007520 catalytic residue; other site
688245007521 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245007522 rrf2 family protein (putative transcriptional regulator); Region: rrf2_super; TIGR00738
688245007523 excinuclease ABC subunit B; Provisional; Region: PRK05298
688245007524 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
688245007525 ATP binding site; other site
688245007526 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
688245007527 nucleotide binding region; other site
688245007528 ATP-binding site; other site
688245007529 Ultra-violet resistance protein B; Region: UvrB; pfam12344
688245007530 UvrB/uvrC motif; Region: UVR; pfam02151
688245007531 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688245007532 pyridoxal 5'-phosphate binding site; other site
688245007533 homodimer interface; other site
688245007534 catalytic residue; other site
688245007535 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
688245007536 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
688245007537 putative active site; other site
688245007538 metal-binding site
688245007539 CoA-transferase family III; Region: CoA_transf_3; cl00778
688245007540 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
688245007541 active site
688245007542 catalytic tetrad; other site
688245007543 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
688245007544 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245007545 Subunit B of the Class III extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of protocatechuate; Region: PCA_45_Dioxygenase_B; cd07364
688245007546 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
688245007547 active site
688245007548 Fe(II) binding site; other site
688245007549 dimer interface; other site
688245007550 tetramer interface; other site
688245007551 The A subunit of Protocatechuate 4,5-dioxygenase (LigAB) is the smaller, non-catalytic subunit; Region: PCA_45_Doxase_A; cd07924
688245007552 tetramer interface; other site
688245007553 dimer interface; other site
688245007554 active site
688245007555 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
688245007556 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311
688245007557 active site
688245007558 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
688245007559 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
688245007560 benzoate transport; Region: 2A0115; TIGR00895
688245007561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245007562 putative substrate translocation pore; other site
688245007563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245007564 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245007565 Cytochrome P450; Region: p450; cl12078
688245007566 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
688245007567 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563
688245007568 Glycosyltransferase family 29 (sialyltransferase); Region: Glyco_transf_29; pfam00777
688245007569 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
688245007570 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
688245007571 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
688245007572 active site
688245007573 dimer interface; other site
688245007574 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
688245007575 dimer interface; other site
688245007576 active site
688245007577 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
688245007578 active site
688245007579 tetramer interface; other site
688245007580 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245007581 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
688245007582 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
688245007583 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
688245007584 Cupin domain; Region: Cupin_2; cl09118
688245007585 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
688245007586 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
688245007587 substrate binding site; other site
688245007588 tetramer interface; other site
688245007589 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987
688245007590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245007591 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
688245007592 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245007593 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
688245007594 Rhamnan synthesis protein F; Region: RgpF; cl01529
688245007595 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
688245007596 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
688245007597 active site
688245007598 Transposase DDE domain; Region: Transposase_11; pfam01609
688245007599 Rhamnan synthesis protein F; Region: RgpF; cl01529
688245007600 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
688245007601 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
688245007602 Probable Catalytic site; other site
688245007603 metal-binding site
688245007604 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
688245007605 Probable Catalytic site; other site
688245007606 metal-binding site
688245007607 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
688245007608 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
688245007609 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
688245007610 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010
688245007611 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245007612 Q-loop/lid; other site
688245007613 ABC transporter signature motif; other site
688245007614 Walker B; other site
688245007615 D-loop; other site
688245007616 H-loop/switch region; other site
688245007617 ABC-2 type transporter; Region: ABC2_membrane; cl11417
688245007618 selenophosphate synthetase; Provisional; Region: PRK00943
688245007619 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
688245007620 dimerization interface; other site
688245007621 putative ATP binding site; other site
688245007622 Transcriptional regulators [Transcription]; Region: Lrp; COG1522
688245007623 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245007624 Domain of unknown function (DUF74); Region: DUF74; cl00426
688245007625 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245007626 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245007627 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245007628 dimerization interface; other site
688245007629 Transcriptional regulators [Transcription]; Region: MarR; COG1846
688245007630 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245007631 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435
688245007632 Cupin domain; Region: Cupin_2; cl09118
688245007633 Cupin domain; Region: Cupin_2; cl09118
688245007634 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
688245007635 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Zeta; cd03042
688245007636 maleylacetoacetate isomerase; Region: maiA; TIGR01262
688245007637 C-terminal domain interface; other site
688245007638 GSH binding site (G-site); other site
688245007639 putative dimer interface; other site
688245007640 GST_C family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_C_Zeta; cd03191
688245007641 dimer interface; other site
688245007642 N-terminal domain interface; other site
688245007643 putative maleylacetoacetate (MAA) substrate binding site (H site); other site
688245007644 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245007645 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
688245007646 tetrameric interface; other site
688245007647 NAD binding site; other site
688245007648 catalytic residues; other site
688245007649 Protein of unknown function (DUF1311); Region: DUF1311; cl01530
688245007650 Protein of unknown function (DUF1311); Region: DUF1311; cl01530
688245007651 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
688245007652 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245007653 active site
688245007654 Protein of unknown function, DUF488; Region: DUF488; cl01246
688245007655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245007656 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
688245007657 Cupin domain; Region: Cupin_2; cl09118
688245007658 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245007659 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
688245007660 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
688245007661 tetrameric interface; other site
688245007662 NAD binding site; other site
688245007663 catalytic residues; other site
688245007664 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245007665 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
688245007666 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245007667 dimerization interface; other site
688245007668 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
688245007669 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245007670 active site
688245007671 Cupin domain; Region: Cupin_2; cl09118
688245007672 CoA-transferase family III; Region: CoA_transf_3; cl00778
688245007673 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245007674 Cupin domain; Region: Cupin_2; cl09118
688245007675 potential frameshift: common BLAST hit: gi|160899103|ref|YP_001564685.1| transcriptional regulator
688245007676 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
688245007677 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245007678 DNA binding site
688245007679 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688245007680 pyridoxal 5'-phosphate binding site; other site
688245007681 LysE type translocator; Region: LysE; cl00565
688245007682 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00443
688245007683 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
688245007684 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
688245007685 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
688245007686 active site residue
688245007687 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
688245007688 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
688245007689 catalytic motif; other site
688245007690 Catalytic residue; other site
688245007691 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
688245007692 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
688245007693 catalytic residues; other site
688245007694 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
688245007695 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493
688245007696 Trp docking motif; other site
688245007697 active site
688245007698 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493
688245007699 'Velcro' closure; other site
688245007700 isocitrate dehydrogenase; Validated; Region: PRK07362
688245007701 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
688245007702 Uncharacterized ACR, COG1430; Region: DUF192; cl00627
688245007703 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245007704 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
688245007705 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
688245007706 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
688245007707 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
688245007708 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971
688245007709 H-NS histone family; Region: Histone_HNS; pfam00816
688245007710 Domain in histone-like proteins of HNS family; Region: HNS; cl09251
688245007711 CHASE3 domain; Region: CHASE3; cl05000
688245007712 PAS fold; Region: PAS_4; pfam08448
688245007713 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
688245007714 putative active site; other site
688245007715 heme pocket; other site
688245007716 PAS fold; Region: PAS_4; pfam08448
688245007717 GAF domain; Region: GAF; cl00853
688245007718 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245007719 metal-binding site
688245007720 active site
688245007721 I-site; other site
688245007722 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
688245007723 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747
688245007724 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
688245007725 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
688245007726 putative active site; other site
688245007727 metal-binding site
688245007728 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
688245007729 superoxide dismutase; Provisional; Region: PRK10543
688245007730 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
688245007731 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
688245007732 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489
688245007733 generic binding surface II; other site
688245007734 generic binding surface I; other site
688245007735 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
688245007736 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
688245007737 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
688245007738 Dyp-type peroxidase family; Region: Dyp_perox; cl01067
688245007739 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; cl10449
688245007740 CHAD domain; Region: CHAD; cl10506
688245007741 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
688245007742 active site
688245007743 catalytic tetrad; other site
688245007744 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245007745 dimerization interface; other site
688245007746 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688245007747 Citrate transporter; Region: CitMHS; pfam03600
688245007748 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652
688245007749 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
688245007750 Trm112p-like protein; Region: Trm112p; cl01066
688245007751 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
688245007752 Ligand binding site; other site
688245007753 oligomer interface; other site
688245007754 adenylate kinase; Reviewed; Region: adk; PRK00279
688245007755 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
688245007756 AMP-binding site; other site
688245007757 ATP-AMP (Ap5A)-binding site; other site
688245007758 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216
688245007759 active site/substrate binding site
688245007760 tetramer interface; other site
688245007761 LexA repressor; Validated; Region: PRK00215
688245007762 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245007763 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529
688245007764 Catalytic site; other site
688245007765 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
688245007766 Ligand Binding Site; other site
688245007767 nitrobindin heme-binding domain; Region: nitrobindin; cd07828
688245007768 heme-binding site; other site
688245007769 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
688245007770 Ligand Binding Site; other site
688245007771 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
688245007772 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
688245007773 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
688245007774 active site
688245007775 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959
688245007776 Cupin domain; Region: Cupin_2; cl09118
688245007777 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
688245007778 Domain of unknown function (DUF333); Region: DUF333; pfam03891
688245007779 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245007780 metal-binding site
688245007781 active site
688245007782 I-site; other site
688245007783 Protein of unknown function (DUF1275); Region: DUF1275; cl01453
688245007784 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245007785 metal-binding site
688245007786 active site
688245007787 I-site; other site
688245007788 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
688245007789 PAS fold; Region: PAS_4; pfam08448
688245007790 putative active site; other site
688245007791 heme pocket; other site
688245007792 PAS domain S-box; Region: sensory_box; TIGR00229
688245007793 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
688245007794 putative active site; other site
688245007795 heme pocket; other site
688245007796 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245007797 metal-binding site
688245007798 active site
688245007799 I-site; other site
688245007800 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
688245007801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245007802 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106
688245007803 leucyl aminopeptidase; Provisional; Region: PRK00913
688245007804 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433
688245007805 interface (dimer of trimers); other site
688245007806 Substrate-binding/catalytic site; other site
688245007807 Zn-binding sites; other site
688245007808 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; cl12074
688245007809 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; cl12074
688245007810 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_N; cd03416
688245007811 putative active site; other site
688245007812 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12682
688245007813 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245007814 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
688245007815 substrate binding site; other site
688245007816 dimerization interface; other site
688245007817 putative aminotransferase; Validated; Region: PRK09082
688245007818 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688245007819 pyridoxal 5'-phosphate binding site; other site
688245007820 homodimer interface; other site
688245007821 catalytic residue; other site
688245007822 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411
688245007823 active site
688245007824 metal-binding site
688245007825 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
688245007826 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
688245007827 Predicted secreted protein [Function unknown]; Region: COG5501; cl02313
688245007828 Cytochrome c; Region: Cytochrom_C; cl11414
688245007829 Cytochrome c; Region: Cytochrom_C; cl11414
688245007830 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
688245007831 Moco binding site; other site
688245007832 metal coordination site; other site
688245007833 Cytochrome c; Region: Cytochrom_C; cl11414
688245007834 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
688245007835 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
688245007836 DsrE/DsrF-like family; Region: DrsE; cl00672
688245007837 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
688245007838 dimerization interface; other site
688245007839 putative DNA binding site; other site
688245007840 putative Zn2+ binding site; other site
688245007841 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424
688245007842 dimer interface; other site
688245007843 ADP-ribose binding site; other site
688245007844 active site
688245007845 nudix motif; other site
688245007846 metal-binding site
688245007847 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
688245007848 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl01276
688245007849 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245007850 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
688245007851 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
688245007852 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184
688245007853 substrate binding pocket; other site
688245007854 active site
688245007855 iron coordination sites; other site
688245007856 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245007857 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245007858 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342
688245007859 trimer interface; other site
688245007860 eyelet of channel; other site
688245007861 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938
688245007862 iron-sulfur cluster; other site
688245007863 [2Fe-2S] cluster binding site; other site
688245007864 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
688245007865 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
688245007866 catalytic residues; other site
688245007867 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
688245007868 Quinone oxidoreductase (QOR); Region: QOR2; cd05286
688245007869 NADP binding site; other site
688245007870 dimer interface; other site
688245007871 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
688245007872 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
688245007873 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245007874 active site
688245007875 ribonuclease G; Provisional; Region: PRK11712
688245007876 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
688245007877 homodimer interface; other site
688245007878 oligonucleotide binding site; other site
688245007879 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
688245007880 active site
688245007881 dimer interface; other site
688245007882 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679
688245007883 Domain of unknown function DUF143; Region: DUF143; cl00519
688245007884 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433
688245007885 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
688245007886 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
688245007887 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
688245007888 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
688245007889 Domain of unknown function DUF28; Region: DUF28; cl00361
688245007890 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245007891 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
688245007892 Walker A motif; other site
688245007893 ATP binding site; other site
688245007894 potential frameshift: common BLAST hit: gi|160898914|ref|YP_001564496.1| methyl-accepting chemotaxis sensory transducer
688245007895 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
688245007896 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144
688245007897 enoyl-CoA hydratase; Provisional; Region: PRK06142
688245007898 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
688245007899 substrate binding site; other site
688245007900 oxyanion hole (OAH) forming residues; other site
688245007901 trimer interface; other site
688245007902 serine racemase; Region: PLN02970
688245007903 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
688245007904 tetramer interface; other site
688245007905 pyridoxal 5'-phosphate binding site; other site
688245007906 catalytic residue; other site
688245007907 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
688245007908 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245007909 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
688245007910 potential catalytic triad; other site
688245007911 conserved cys residue; other site
688245007912 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
688245007913 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
688245007914 DNA binding residues
688245007915 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
688245007916 Domain of unknown function DUF28; Region: DUF28; cl00361
688245007917 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
688245007918 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
688245007919 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
688245007920 Nucleoside recognition; Region: Gate; cl00486
688245007921 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
688245007922 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
688245007923 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
688245007924 substrate binding pocket; other site
688245007925 membrane-bound complex binding site; other site
688245007926 hinge residues; other site
688245007927 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
688245007928 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245007929 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245007930 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
688245007931 putative dimerization interface; other site
688245007932 exonuclease I; Provisional; Region: sbcB; PRK11779
688245007933 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
688245007934 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
688245007935 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032
688245007936 Membrane transport protein; Region: Mem_trans; cl09117
688245007937 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
688245007938 dimerization interface; other site
688245007939 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
688245007940 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144
688245007941 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
688245007942 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
688245007943 conserved cys residue; other site
688245007944 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
688245007945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245007946 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
688245007947 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
688245007948 dimer interface; other site
688245007949 active site
688245007950 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
688245007951 CoenzymeA binding site; other site
688245007952 subunit interaction site; other site
688245007953 PHB binding site; other site
688245007954 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409
688245007955 NAD+ binding site; other site
688245007956 substrate binding site; other site
688245007957 Zn binding site; other site
688245007958 cardiolipin synthetase; Reviewed; Region: cls; PRK01642
688245007959 Phospholipase D. Active site motifs; The PLD superfamily includes enzymes involved in signal transduction, lipid biosynthesis, endonucleases and open reading frames in pathogenic viruses and bacteria. PLD hydrolyzes the terminal phosphodiester bond of...; Region: PLDc; cd00138
688245007960 active site
688245007961 signature motif; other site
688245007962 Phospholipase D. Active site motifs; The PLD superfamily includes enzymes involved in signal transduction, lipid biosynthesis, endonucleases and open reading frames in pathogenic viruses and bacteria. PLD hydrolyzes the terminal phosphodiester bond of...; Region: PLDc; cd00138
688245007963 active site
688245007964 signature motif; other site
688245007965 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
688245007966 non-specific DNA binding site; other site
688245007967 salt bridge; other site
688245007968 sequence-specific DNA binding site; other site
688245007969 GAF domain; Region: GAF; cl00853
688245007970 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
688245007971 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
688245007972 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
688245007973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245007974 d-galactonate transporter; Region: 2A0114; TIGR00893
688245007975 putative substrate translocation pore; other site
688245007976 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
688245007977 Beta-lactamase; Region: Beta-lactamase; cl01009
688245007978 dihydropyrimidinase; Provisional; Region: PRK13404
688245007979 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like...; Region: D-HYD; cd01314
688245007980 tetramer interface; other site
688245007981 active site
688245007982 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
688245007983 Transcriptional regulators [Transcription]; Region: FadR; COG2186
688245007984 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245007985 DNA binding site
688245007986 FCD domain; Region: FCD; cl11656
688245007987 Chromate transporter; Region: Chromate_transp; cl00902
688245007988 Chromate transporter; Region: Chromate_transp; cl00902
688245007989 NAD-dependent deacetylase; Provisional; Region: PRK14138
688245007990 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes...; Region: SIRT5_Af1_CobB; cd01412
688245007991 NAD+ binding site; other site
688245007992 substrate binding site; other site
688245007993 Zn binding site; other site
688245007994 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
688245007995 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
688245007996 putative active site; other site
688245007997 heme pocket; other site
688245007998 sensory histidine kinase AtoS; Provisional; Region: PRK11360
688245007999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245008000 ATP binding site; other site
688245008001 Mg2+ binding site; other site
688245008002 G-X-G motif; other site
688245008003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245008004 active site
688245008005 phosphorylation site
688245008006 intermolecular recognition site; other site
688245008007 dimerization interface; other site
688245008008 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
688245008009 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
688245008010 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
688245008011 Sodium:dicarboxylate symporter family; Region: SDF; cl00573
688245008012 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
688245008013 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
688245008014 Walker A/P-loop; other site
688245008015 ATP binding site; other site
688245008016 Q-loop/lid; other site
688245008017 ABC transporter signature motif; other site
688245008018 Walker B; other site
688245008019 D-loop; other site
688245008020 H-loop/switch region; other site
688245008021 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
688245008022 active site
688245008023 catalytic triad; other site
688245008024 oxyanion hole; other site
688245008025 switch loop; other site
688245008026 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
688245008027 cystathionine beta-lyase; Provisional; Region: PRK07050
688245008028 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
688245008029 pyridoxal 5'-phosphate binding pocket; other site
688245008030 catalytic residue; other site
688245008031 Putative phospholipid-binding domain; Region: BON; cl02771
688245008032 Major Facilitator Superfamily; Region: MFS_1; pfam07690
688245008033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245008034 putative substrate translocation pore; other site
688245008035 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
688245008036 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
688245008037 nucleophile elbow; other site
688245008038 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
688245008039 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
688245008040 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245008041 active site
688245008042 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
688245008043 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
688245008044 dimer interface; other site
688245008045 active site
688245008046 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
688245008047 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
688245008048 substrate binding site; other site
688245008049 oxyanion hole (OAH) forming residues; other site
688245008050 trimer interface; other site
688245008051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245008052 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
688245008053 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
688245008054 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
688245008055 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
688245008056 Walker A/P-loop; other site
688245008057 ATP binding site; other site
688245008058 Q-loop/lid; other site
688245008059 ABC transporter signature motif; other site
688245008060 Walker B; other site
688245008061 D-loop; other site
688245008062 H-loop/switch region; other site
688245008063 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
688245008064 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219
688245008065 Walker A/P-loop; other site
688245008066 ATP binding site; other site
688245008067 Q-loop/lid; other site
688245008068 ABC transporter signature motif; other site
688245008069 Walker B; other site
688245008070 D-loop; other site
688245008071 H-loop/switch region; other site
688245008072 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
688245008073 TM-ABC transporter signature motif; other site
688245008074 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
688245008075 TM-ABC transporter signature motif; other site
688245008076 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
688245008077 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
688245008078 putative ligand binding site; other site
688245008079 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
688245008080 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
688245008081 putative ligand binding site; other site
688245008082 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245008083 putative acyl-CoA synthetase; Provisional; Region: PRK06018
688245008084 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; cl00428
688245008085 SelR domain; Region: SelR; cl00369
688245008086 Intracellular septation protein A; Region: IspA; cl01098
688245008087 BolA-like protein; Region: BolA; cl00386
688245008088 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
688245008089 PPIC-type PPIASE domain; Region: Rotamase; cl08278
688245008090 RNA polymerase sigma factor; Provisional; Region: PRK12513
688245008091 Sodium:solute symporter family; Region: SSF; cl00456
688245008092 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
688245008093 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
688245008094 Bacterial SH3 domain; Region: SH3_3; cl02551
688245008095 Bacterial SH3 domain; Region: SH3_3; cl02551
688245008096 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
688245008097 dimer interface; other site
688245008098 substrate binding site; other site
688245008099 ATP binding site; other site
688245008100 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245008101 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
688245008102 thiS-thiF/thiG interaction site; other site
688245008103 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
688245008104 ThiS interaction site; other site
688245008105 putative active site; other site
688245008106 tetramer interface; other site
688245008107 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta...; Region: TMP_TenI; cd00564
688245008108 active site
688245008109 thiamine phosphate binding site; other site
688245008110 pyrophosphate binding site; other site
688245008111 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
688245008112 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
688245008113 ligand binding site; other site
688245008114 flexible hinge region; other site
688245008115 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
688245008116 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154
688245008117 putative active site; other site
688245008118 putative substrate binding site; other site
688245008119 ATP binding site; other site
688245008120 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
688245008121 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245008122 active site
688245008123 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
688245008124 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
688245008125 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144
688245008126 peptide chain release factor 2; Provisional; Region: PRK08787
688245008127 RF-1 domain; Region: RF-1; cl02875
688245008128 RF-1 domain; Region: RF-1; cl02875
688245008129 aminopeptidase N; Provisional; Region: pepN; PRK14015
688245008130 Peptidase family M1; Region: Peptidase_M1; pfam01433
688245008131 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1,7-...; Region: FBPase; cd00354
688245008132 AMP binding site; other site
688245008133 metal-binding site
688245008134 active site
688245008135 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222
688245008136 catalytic residue; other site
688245008137 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
688245008138 Domain of unknown function (DUF927); Region: DUF927; cl12098
688245008139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
688245008140 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
688245008141 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
688245008142 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
688245008143 Int/Topo IB signature motif; other site
688245008144 active site
688245008145 DNA binding site
688245008146 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
688245008147 rRNA binding site; other site
688245008148 predicted 30S ribosome binding site; other site
688245008149 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
688245008150 Cache domain; Region: Cache_1; pfam02743
688245008151 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245008152 metal-binding site
688245008153 active site
688245008154 I-site; other site
688245008155 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245008156 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245008157 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
688245008158 putative dimerization interface; other site
688245008159 Membrane transport protein; Region: Mem_trans; cl09117
688245008160 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245008161 active site
688245008162 I-site; other site
688245008163 metal-binding site
688245008164 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
688245008165 Bacterial protein of unknown function (DUF920); Region: DUF920; cl01479
688245008166 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
688245008167 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
688245008168 metal ion-dependent adhesion site (MIDAS); other site
688245008169 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108
688245008170 VCBS repeat; Region: VCBS_repeat; TIGR01965
688245008171 VCBS repeat; Region: VCBS_repeat; TIGR01965
688245008172 Cadherin repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion; these domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium; plays a role in cell...; Region: CA; cl02468
688245008173 Ca2+ binding site; other site
688245008174 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
688245008175 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
688245008176 DNA binding residues
688245008177 dimerization interface; other site
688245008178 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
688245008179 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421
688245008180 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
688245008181 ABC transporter transmembrane region; Region: ABC_membrane; cl00549
688245008182 ABC-type bacteriocin exporters. Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two...; Region: ABCC_bacteriocin_exporters; cd03245
688245008183 Walker A/P-loop; other site
688245008184 ATP binding site; other site
688245008185 Q-loop/lid; other site
688245008186 ABC transporter signature motif; other site
688245008187 Walker B; other site
688245008188 D-loop; other site
688245008189 H-loop/switch region; other site
688245008190 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
688245008191 Outer membrane efflux protein; Region: OEP; pfam02321
688245008192 Outer membrane efflux protein; Region: OEP; pfam02321
688245008193 Transposase DDE domain; Region: Transposase_11; pfam01609
688245008194 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
688245008195 DNA binding residues
688245008196 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher...; Region: HU_IHF; cd00591
688245008197 IHF dimer interface; other site
688245008198 IHF - DNA interface; other site
688245008199 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
688245008200 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
688245008201 putative tRNA-binding site; other site
688245008202 B3/4 domain; Region: B3_4; cl11458
688245008203 tRNA synthetase B5 domain; Region: B5; cl08394
688245008204 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769
688245008205 dimer interface; other site
688245008206 motif 1; other site
688245008207 motif 3; other site
688245008208 motif 2; other site
688245008209 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
688245008210 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
688245008211 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
688245008212 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
688245008213 dimer interface; other site
688245008214 motif 1; other site
688245008215 active site
688245008216 motif 2; other site
688245008217 motif 3; other site
688245008218 Ribosomal protein L20; Region: Ribosomal_L20; cl00393
688245008219 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
688245008220 translation initiation factor IF-3; Region: infC; TIGR00168
688245008221 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
688245008222 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
688245008223 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
688245008224 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667
688245008225 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
688245008226 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
688245008227 active site
688245008228 dimer interface; other site
688245008229 motif 1; other site
688245008230 motif 2; other site
688245008231 motif 3; other site
688245008232 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
688245008233 anticodon binding site; other site
688245008234 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
688245008235 tetramer interface; other site
688245008236 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513
688245008237 active site
688245008238 Mg2+/Mn2+ binding site; other site
688245008239 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
688245008240 EamA-like transporter family; Region: EamA; cl01037
688245008241 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
688245008242 SWIB/MDM2 domain; Region: SWIB; cl02489
688245008243 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
688245008244 non-specific DNA binding site; other site
688245008245 salt bridge; other site
688245008246 sequence-specific DNA binding site; other site
688245008247 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
688245008248 NADPH-dependent FMN reductase; Region: FMN_red; cl00438
688245008249 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200
688245008250 FAD binding pocket; other site
688245008251 FAD binding motif; other site
688245008252 catalytic residues; other site
688245008253 NAD binding pocket; other site
688245008254 phosphate binding motif; other site
688245008255 beta-alpha-beta structure motif; other site
688245008256 ApbE family; Region: ApbE; cl00643
688245008257 Nickel uptake substrate-specific transmembrane region; Region: NikM; pfam10670
688245008258 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266
688245008259 Predicted periplasmic protein (DUF2271); Region: DUF2271; cl01469
688245008260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
688245008261 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
688245008262 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245008263 N-terminal plug; other site
688245008264 ligand-binding site; other site
688245008265 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206
688245008266 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
688245008267 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
688245008268 active site
688245008269 substrate binding site; other site
688245008270 FMN binding site; other site
688245008271 putative catalytic residues; other site
688245008272 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
688245008273 Gram-negative bacterial tonB protein; Region: TonB; cl10048
688245008274 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
688245008275 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
688245008276 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
688245008277 Hemin uptake protein hemP; Region: hemP; cl10043
688245008278 Domain of unknown function (DUF336); Region: DUF336; cl01249
688245008279 BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cd06181
688245008280 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811
688245008281 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
688245008282 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
688245008283 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
688245008284 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
688245008285 23S rRNA 5-methyluridine methyltransferase; Reviewed; Region: rumA; PRK13168
688245008286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245008287 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245008288 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
688245008289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245008290 Predicted integral membrane protein (DUF2269); Region: DUF2269; cl02335
688245008291 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
688245008292 putative active site; other site
688245008293 heme pocket; other site
688245008294 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
688245008295 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144
688245008296 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
688245008297 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245008298 Proline dehydrogenase; Region: Pro_dh; cl03282
688245008299 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
688245008300 NAD(P) binding site; other site
688245008301 catalytic residues; other site
688245008302 TOBE domain; Region: TOBE_2; cl01440
688245008303 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684
688245008304 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245008305 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
688245008306 substrate binding site; other site
688245008307 dimerization interface; other site
688245008308 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
688245008309 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
688245008310 Walker A/P-loop; other site
688245008311 ATP binding site; other site
688245008312 Q-loop/lid; other site
688245008313 ABC transporter signature motif; other site
688245008314 Walker B; other site
688245008315 D-loop; other site
688245008316 H-loop/switch region; other site
688245008317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245008318 putative PBP binding loops; other site
688245008319 dimer interface; other site
688245008320 ABC-ATPase subunit interface; other site
688245008321 potential frameshift: common BLAST hit: gi|160900070|ref|YP_001565652.1| alkanesulfonate monooxygenase
688245008322 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
688245008323 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
688245008324 active site
688245008325 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
688245008326 dimer interface; other site
688245008327 non-prolyl cis peptide bond; other site
688245008328 insertion regions; other site
688245008329 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
688245008330 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
688245008331 substrate binding pocket; other site
688245008332 membrane-bound complex binding site; other site
688245008333 hinge residues; other site
688245008334 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
688245008335 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
688245008336 substrate binding pocket; other site
688245008337 membrane-bound complex binding site; other site
688245008338 NADPH-dependent FMN reductase; Region: FMN_red; cl00438
688245008339 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245008340 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104
688245008341 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245008342 metal-binding site
688245008343 active site
688245008344 I-site; other site
688245008345 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
688245008346 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245008347 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
688245008348 dimerization interface; other site
688245008349 substrate binding pocket; other site
688245008350 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
688245008351 active site
688245008352 catalytic tetrad; other site
688245008353 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; cl10449
688245008354 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
688245008355 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245008356 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
688245008357 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
688245008358 phosphate binding site; other site
688245008359 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
688245008360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245008361 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
688245008362 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
688245008363 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245008364 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
688245008365 enoyl-CoA hydratase; Provisional; Region: PRK06142
688245008366 substrate binding site; other site
688245008367 oxyanion hole (OAH) forming residues; other site
688245008368 trimer interface; other site
688245008369 CoA-transferase family III; Region: CoA_transf_3; cl00778
688245008370 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
688245008371 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
688245008372 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
688245008373 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245008374 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
688245008375 dimerization interface; other site
688245008376 substrate binding pocket; other site
688245008377 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
688245008378 dimer interface; other site
688245008379 NADP binding site; other site
688245008380 catalytic residues; other site
688245008381 metabolite-proton symporter; Region: 2A0106; TIGR00883
688245008382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245008383 putative substrate translocation pore; other site
688245008384 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
688245008385 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
688245008386 putative active site; other site
688245008387 metal-binding site
688245008388 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245008389 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710
688245008390 DctM-like transporters; Region: DctM; pfam06808
688245008391 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688245008392 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
688245008393 NIPSNAP; Region: NIPSNAP; pfam07978
688245008394 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
688245008395 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
688245008396 active site
688245008397 NAD binding site; other site
688245008398 metal-binding site
688245008399 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245008400 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245008401 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245008402 dimerization interface; other site
688245008403 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382
688245008404 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
688245008405 active site
688245008406 catalytic tetrad; other site
688245008407 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
688245008408 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
688245008409 FMN binding site; other site
688245008410 active site
688245008411 substrate binding site; other site
688245008412 catalytic residue; other site
688245008413 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
688245008414 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
688245008415 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
688245008416 active site
688245008417 catalytic tetrad; other site
688245008418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245008419 putative substrate translocation pore; other site
688245008420 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245008421 putative substrate translocation pore; other site
688245008422 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245008423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245008424 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478
688245008425 putative effector binding pocket; other site
688245008426 dimerization interface; other site
688245008427 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
688245008428 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
688245008429 DNA binding residues
688245008430 dimer interface; other site
688245008431 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
688245008432 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245008433 Uncharacterized conserved protein [Function unknown]; Region: COG2128
688245008434 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245008435 C-term; Region: GreA_GreB; pfam01272
688245008436 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245008437 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
688245008438 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245008439 DNA binding site
688245008440 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688245008441 pyridoxal 5'-phosphate binding site; other site
688245008442 homodimer interface; other site
688245008443 catalytic residue; other site
688245008444 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
688245008445 homodimer interface; other site
688245008446 NAD binding site; other site
688245008447 catalytic residues; other site
688245008448 substrate binding pocket; other site
688245008449 flexible flap; other site
688245008450 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
688245008451 active site
688245008452 catalytic residues; other site
688245008453 metal-binding site
688245008454 Nickel uptake substrate-specific transmembrane region; Region: NikM; pfam10670
688245008455 Secretin and TonB N terminus short domain; Region: STN; pfam07660
688245008456 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
688245008457 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245008458 N-terminal plug; other site
688245008459 ligand-binding site; other site
688245008460 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
688245008461 FecR protein; Region: FecR; pfam04773
688245008462 RNA polymerase sigma factor; Reviewed; Region: PRK12527
688245008463 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055
688245008464 Cupin domain; Region: Cupin_2; cl09118
688245008465 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
688245008466 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
688245008467 Sulfite exporter TauE/SafE; Region: TauE; cl00498
688245008468 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333
688245008469 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
688245008470 dimer interface; other site
688245008471 active site
688245008472 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
688245008473 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
688245008474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
688245008475 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342
688245008476 trimer interface; other site
688245008477 eyelet of channel; other site
688245008478 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245008479 FAD binding domain; Region: FAD_binding_3; pfam01494
688245008480 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245008481 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245008482 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
688245008483 dimerization interface; other site
688245008484 putative effector binding pocket; other site
688245008485 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
688245008486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245008487 Major Facilitator Superfamily; Region: MFS_1; pfam07690
688245008488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245008489 NADPH-dependent FMN reductase; Region: FMN_red; cl00438
688245008490 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
688245008491 catalytic residues; other site
688245008492 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
688245008493 transmembrane helices; other site
688245008494 Low molecular weight phosphatase family; Region: LMWPc; cd00115
688245008495 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
688245008496 active site
688245008497 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
688245008498 dimerization interface; other site
688245008499 putative DNA binding site; other site
688245008500 putative Zn2+ binding site; other site
688245008501 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
688245008502 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
688245008503 active site 1
688245008504 dimer interface; other site
688245008505 hexamer interface; other site
688245008506 active site 2
688245008507 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245008508 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
688245008509 4-hydroxy-2-ketovalerate aldolase; Validated; Region: PRK08195
688245008510 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
688245008511 active site
688245008512 catalytic residues; other site
688245008513 metal-binding site
688245008514 DmpG-like communication domain; Region: DmpG_comm; pfam07836
688245008515 acetaldehyde dehydrogenase; Validated; Region: PRK08300
688245008516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245008517 Prokaryotic acetaldehyde dehydrogenase, dimerization; Region: AcetDehyd-dimer; pfam09290
688245008518 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
688245008519 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
688245008520 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245008521 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
688245008522 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
688245008523 NAD binding site; other site
688245008524 catalytic residues; other site
688245008525 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
688245008526 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245008527 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the chlorocatechol catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_Chlorocatechol; cd08446
688245008528 dimerization interface; other site
688245008529 putative substrate binding pocket; other site
688245008530 Domain of unknown function (DUF336); Region: DUF336; cl01249
688245008531 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313
688245008532 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211
688245008533 N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265
688245008534 tetramer interface; other site
688245008535 C-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_C; cd07243
688245008536 tetramer interface; other site
688245008537 active site
688245008538 Fe binding site; other site
688245008539 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
688245008540 catalytic loop; other site
688245008541 iron binding site; other site
688245008542 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
688245008543 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
688245008544 catalytic loop; other site
688245008545 iron binding site; other site
688245008546 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868
688245008547 FAD binding pocket; other site
688245008548 conserved FAD binding motif; other site
688245008549 phosphate binding motif; other site
688245008550 beta-alpha-beta structure motif; other site
688245008551 NAD binding pocket; other site
688245008552 Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663
688245008553 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057
688245008554 dimerization interface; other site
688245008555 putative path to active site cavity; other site
688245008556 diiron center; other site
688245008557 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406
688245008558 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058
688245008559 dimerization interface; other site
688245008560 Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099
688245008561 Activator of aromatic catabolism; Region: XylR_N; pfam06505
688245008562 V4R domain; Region: V4R; cl08369
688245008563 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
688245008564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245008565 Walker A motif; other site
688245008566 ATP binding site; other site
688245008567 Walker B motif; other site
688245008568 arginine finger; other site
688245008569 Transcriptional regulators [Transcription]; Region: GntR; COG1802
688245008570 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245008571 DNA binding site
688245008572 FCD domain; Region: FCD; cl11656
688245008573 Predicted membrane protein [Function unknown]; Region: COG2860
688245008574 UPF0126 domain; Region: UPF0126; pfam03458
688245008575 UPF0126 domain; Region: UPF0126; pfam03458
688245008576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245008577 5-methylaminomethyl-2-thiouridine methyltransferase; Reviewed; Region: mnmC; PRK01747
688245008578 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245008579 Domain of unknown function DUF21; Region: DUF21; pfam01595
688245008580 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
688245008581 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
688245008582 Transporter associated domain; Region: CorC_HlyC; pfam03471
688245008583 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
688245008584 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
688245008585 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
688245008586 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526
688245008587 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
688245008588 Active Sites; active site
688245008589 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
688245008590 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
688245008591 Active Sites; active site
688245008592 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
688245008593 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras; Region: Ras_like_GTPase; cl10444
688245008594 G1 box; other site
688245008595 GTP/Mg2+ binding site; other site
688245008596 G2 box; other site
688245008597 Switch I region; other site
688245008598 G3 box; other site
688245008599 Switch II region; other site
688245008600 G4 box; other site
688245008601 G5 box; other site
688245008602 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695
688245008603 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NoDQ_III; cd04095
688245008604 Ferredoxin [Energy production and conversion]; Region: COG1146
688245008605 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
688245008606 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
688245008607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245008608 Permease family; Region: Xan_ur_permease; cl00967
688245008609 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe...; Region: Pep_deformylase; cd00487
688245008610 active site
688245008611 catalytic residues; other site
688245008612 metal-binding site
688245008613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245008614 Predicted flavoproteins [General function prediction only]; Region: COG2081
688245008615 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245008616 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
688245008617 catalytic residues; other site
688245008618 transcription termination factor Rho; Provisional; Region: rho; PRK09376
688245008619 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
688245008620 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459
688245008621 RNA binding site; other site
688245008622 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128
688245008623 multimer interface; other site
688245008624 Walker A motif; other site
688245008625 ATP binding site; other site
688245008626 Walker B motif; other site
688245008627 NodT family; Region: outer_NodT; TIGR01845
688245008628 Outer membrane efflux protein; Region: OEP; pfam02321
688245008629 Outer membrane efflux protein; Region: OEP; pfam02321
688245008630 hypothetical protein; Provisional; Region: PRK03598
688245008631 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404
688245008632 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
688245008633 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245008634 Walker A/P-loop; other site
688245008635 ATP binding site; other site
688245008636 Q-loop/lid; other site
688245008637 ABC transporter signature motif; other site
688245008638 Walker B; other site
688245008639 D-loop; other site
688245008640 H-loop/switch region; other site
688245008641 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245008642 Walker A/P-loop; other site
688245008643 ATP binding site; other site
688245008644 Q-loop/lid; other site
688245008645 ABC transporter signature motif; other site
688245008646 Walker B; other site
688245008647 D-loop; other site
688245008648 H-loop/switch region; other site
688245008649 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
688245008650 ABC-2 type transporter; Region: ABC2_membrane; cl11417
688245008651 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
688245008652 ABC-2 type transporter; Region: ABC2_membrane; cl11417
688245008653 acetate kinase; Reviewed; Region: PRK12440
688245008654 Acetokinase family; Region: Acetate_kinase; cl01029
688245008655 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
688245008656 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245008657 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
688245008658 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
688245008659 Ribosomal protein L31; Region: Ribosomal_L31; cl00377
688245008660 putative efflux protein, MATE family; Region: matE; TIGR00797
688245008661 MatE; Region: MatE; pfam01554
688245008662 MatE; Region: MatE; pfam01554
688245008663 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
688245008664 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
688245008665 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
688245008666 dimer interface; other site
688245008667 phosphorylation site
688245008668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245008669 ATP binding site; other site
688245008670 Mg2+ binding site; other site
688245008671 G-X-G motif; other site
688245008672 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
688245008673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245008674 active site
688245008675 phosphorylation site
688245008676 intermolecular recognition site; other site
688245008677 dimerization interface; other site
688245008678 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
688245008679 DNA binding site
688245008680 transcriptional regulator PhoU; Provisional; Region: PRK11115
688245008681 PhoU domain; Region: PhoU; pfam01895
688245008682 PhoU domain; Region: PhoU; pfam01895
688245008683 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
688245008684 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
688245008685 Walker A/P-loop; other site
688245008686 ATP binding site; other site
688245008687 Q-loop/lid; other site
688245008688 ABC transporter signature motif; other site
688245008689 Walker B; other site
688245008690 D-loop; other site
688245008691 H-loop/switch region; other site
688245008692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
688245008693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245008694 dimer interface; other site
688245008695 conserved gate region; other site
688245008696 putative PBP binding loops; other site
688245008697 ABC-ATPase subunit interface; other site
688245008698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
688245008699 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245008700 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
688245008701 exopolyphosphatase; Region: exo_poly_only; TIGR03706
688245008702 polyphosphate kinase; Provisional; Region: PRK05443
688245008703 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
688245008704 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802
688245008705 active site
688245008706 substrate binding site; other site
688245008707 metal-binding site
688245008708 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
688245008709 substrate binding pocket; other site
688245008710 dimer interface; other site
688245008711 inhibitor binding site; inhibition site
688245008712 FtsH Extracellular; Region: FtsH_ext; pfam06480
688245008713 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
688245008714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245008715 Walker A motif; other site
688245008716 ATP binding site; other site
688245008717 Walker B motif; other site
688245008718 arginine finger; other site
688245008719 Peptidase family M41; Region: Peptidase_M41; pfam01434
688245008720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245008721 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
688245008722 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
688245008723 Protein of unknown function (DUF2843); Region: DUF2843; pfam11004
688245008724 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
688245008725 domain; Region: GreA_GreB_N; pfam03449
688245008726 C-term; Region: GreA_GreB; pfam01272
688245008727 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
688245008728 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
688245008729 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
688245008730 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
688245008731 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
688245008732 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
688245008733 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
688245008734 IMP binding site; other site
688245008735 dimer interface; other site
688245008736 interdomain contacts; other site
688245008737 partial ornithine binding site; other site
688245008738 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
688245008739 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
688245008740 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
688245008741 catalytic site; other site
688245008742 subunit interface; other site
688245008743 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
688245008744 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
688245008745 bacterial Ribonuclease HII-like; Region: RNaseH_typeII_bacteria_HII_like; cd07182
688245008746 active site
688245008747 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
688245008748 ipid-A-disaccharide synthase; Provisional; Region: PRK14089
688245008749 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
688245008750 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A...; Region: LbH_UDP-GlcNAc_AT; cd03351
688245008751 active site
688245008752 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
688245008753 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
688245008754 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
688245008755 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2,3-...; Region: LbH_LpxD; cd03352
688245008756 trimer interface; other site
688245008757 active site
688245008758 UDP-GlcNAc binding site; other site
688245008759 lipid-binding site
688245008760 Outer membrane protein (OmpH-like); Region: OmpH; cl08146
688245008761 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
688245008762 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
688245008763 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
688245008764 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
688245008765 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
688245008766 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
688245008767 Surface antigen; Region: Bac_surface_Ag; cl03097
688245008768 zinc metallopeptidase RseP; Provisional; Region: PRK10779
688245008769 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
688245008770 active site
688245008771 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989
688245008772 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
688245008773 putative substrate binding region; other site
688245008774 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
688245008775 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
688245008776 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
688245008777 Cytidylyltransferase family; Region: CTP_transf_1; cl00347
688245008778 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
688245008779 catalytic residue; other site
688245008780 putative FPP diphosphate binding site; other site
688245008781 putative FPP binding hydrophobic cleft; other site
688245008782 dimer interface; other site
688245008783 putative IPP diphosphate binding site; other site
688245008784 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
688245008785 hinge region; other site
688245008786 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254
688245008787 putative nucleotide binding site; other site
688245008788 uridine monophosphate binding site; other site
688245008789 homohexameric interface; other site
688245008790 elongation factor Ts; Provisional; Region: tsf; PRK09377
688245008791 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
688245008792 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
688245008793 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
688245008794 rRNA interaction site; other site
688245008795 S8 interaction site; other site
688245008796 putative laminin-1 binding site; other site
688245008797 amidase; Provisional; Region: PRK07056
688245008798 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
688245008799 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
688245008800 putative substrate binding site; other site
688245008801 putative ATP binding site; other site
688245008802 ribonuclease R; Region: RNase_R; TIGR02063
688245008803 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
688245008804 RNB domain; Region: RNB; pfam00773
688245008805 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471
688245008806 RNA binding site; other site
688245008807 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
688245008808 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
688245008809 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
688245008810 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
688245008811 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
688245008812 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
688245008813 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254
688245008814 N-acetyl-D-glucosamine binding site; other site
688245008815 catalytic residue; other site
688245008816 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378
688245008817 dimer interface; other site
688245008818 glycine-pyridoxal phosphate binding site; other site
688245008819 active site
688245008820 folate binding site; other site
688245008821 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
688245008822 ATP cone domain; Region: ATP-cone; pfam03477
688245008823 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
688245008824 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
688245008825 putative active site; other site
688245008826 putative metal binding site; other site
688245008827 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
688245008828 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
688245008829 Tetramer interface; other site
688245008830 active site
688245008831 FMN-binding site; other site
688245008832 FOG: CBS domain [General function prediction only]; Region: COG0517
688245008833 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010
688245008834 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134
688245008835 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
688245008836 homodimer interface; other site
688245008837 substrate-cofactor binding pocket; other site
688245008838 pyridoxal 5'-phosphate binding site; other site
688245008839 catalytic residue; other site
688245008840 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
688245008841 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245008842 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245008843 nucleophilic elbow; other site
688245008844 catalytic triad; other site
688245008845 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929
688245008846 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929
688245008847 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
688245008848 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245008849 Protein of unknown function (DUF962); Region: DUF962; cl01879
688245008850 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918
688245008851 Predicted membrane protein (DUF2069); Region: DUF2069; cl01299
688245008852 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245008853 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245008854 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245008855 dimerization interface; other site
688245008856 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
688245008857 FAD binding domain; Region: FAD_binding_4; cl10516
688245008858 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
688245008859 dimerization interface; other site
688245008860 active site
688245008861 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10...; Region: DHFR; cd00209
688245008862 folate binding site; other site
688245008863 NADP+ binding site; other site
688245008864 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
688245008865 active site
688245008866 metal-binding site
688245008867 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
688245008868 Domain of unknown function (DUF333); Region: DUF333; pfam03891
688245008869 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245008870 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245008871 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
688245008872 putative effector binding pocket; other site
688245008873 dimerization interface; other site
688245008874 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245008875 Sulfatase; Region: Sulfatase; cl10460
688245008876 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
688245008877 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342
688245008878 trimer interface; other site
688245008879 eyelet of channel; other site
688245008880 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; cl00490
688245008881 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
688245008882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245008883 active site
688245008884 phosphorylation site
688245008885 intermolecular recognition site; other site
688245008886 dimerization interface; other site
688245008887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245008888 Walker A motif; other site
688245008889 ATP binding site; other site
688245008890 Walker B motif; other site
688245008891 arginine finger; other site
688245008892 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
688245008893 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
688245008894 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans...; Region: HisKA; cd00082
688245008895 dimer interface; other site
688245008896 phosphorylation site
688245008897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245008898 ATP binding site; other site
688245008899 Mg2+ binding site; other site
688245008900 G-X-G motif; other site
688245008901 glutamine synthetase; Provisional; Region: glnA; PRK09469
688245008902 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
688245008903 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
688245008904 Protein of unknown function (DUF540); Region: DUF540; cl01126
688245008905 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
688245008906 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061
688245008907 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567
688245008908 structural tetrad; other site
688245008909 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
688245008910 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
688245008911 adenylosuccinate synthetase; Provisional; Region: PRK01117
688245008912 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras; Region: Ras_like_GTPase; cl10444
688245008913 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras; Region: Ras_like_GTPase; cl10444
688245008914 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
688245008915 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
688245008916 dimer interface; other site
688245008917 motif 1; other site
688245008918 active site
688245008919 motif 2; other site
688245008920 motif 3; other site
688245008921 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; cl01275
688245008922 FtsH protease regulator HflC; Provisional; Region: PRK11029
688245008923 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
688245008924 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
688245008925 HflK protein; Region: hflK; TIGR01933
688245008926 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
688245008927 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878
688245008928 G1 box; other site
688245008929 GTP/Mg2+ binding site; other site
688245008930 Switch I region; other site
688245008931 G2 box; other site
688245008932 G3 box; other site
688245008933 Switch II region; other site
688245008934 G4 box; other site
688245008935 G5 box; other site
688245008936 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716
688245008937 Sm1 motif; other site
688245008938 intra - hexamer interaction site; other site
688245008939 inter - hexamer interaction site; other site
688245008940 nucleotide binding pocket; other site
688245008941 Sm2 motif; other site
688245008942 GTP-binding protein EngA; Reviewed; Region: engA; PRK00093
688245008943 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894
688245008944 G1 box; other site
688245008945 GTP/Mg2+ binding site; other site
688245008946 Switch I region; other site
688245008947 G2 box; other site
688245008948 Switch II region; other site
688245008949 G3 box; other site
688245008950 G4 box; other site
688245008951 G5 box; other site
688245008952 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895
688245008953 G1 box; other site
688245008954 GTP/Mg2+ binding site; other site
688245008955 Switch I region; other site
688245008956 G2 box; other site
688245008957 G3 box; other site
688245008958 Switch II region; other site
688245008959 G4 box; other site
688245008960 G5 box; other site
688245008961 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
688245008962 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493
688245008963 active site
688245008964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
688245008965 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
688245008966 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
688245008967 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
688245008968 dimer interface; other site
688245008969 motif 1; other site
688245008970 active site
688245008971 motif 2; other site
688245008972 motif 3; other site
688245008973 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
688245008974 anticodon binding site; other site
688245008975 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
688245008976 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612
688245008977 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
688245008978 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063
688245008979 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
688245008980 binding surface
688245008981 TPR motif; other site
688245008982 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
688245008983 binding surface
688245008984 TPR motif; other site
688245008985 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
688245008986 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056
688245008987 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
688245008988 active site
688245008989 multimer interface; other site
688245008990 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
688245008991 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
688245008992 RNA binding surface; other site
688245008993 PseudoU_synth_RluB: Pseudouridine synthase, Escherichia coli RluB like. This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluB; cd02556
688245008994 probable active site; other site
688245008995 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
688245008996 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108
688245008997 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
688245008998 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
688245008999 RNA binding surface; other site
688245009000 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
688245009001 active site
688245009002 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
688245009003 Peptidase family M23; Region: Peptidase_M23; pfam01551
688245009004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245009005 Survival protein SurE; Region: SurE; cl00448
688245009006 Quinone oxidoreductase (QOR); Region: QOR1; cd08241
688245009007 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
688245009008 NAD(P) binding site; other site
688245009009 PhoD-like phosphatase; Region: PhoD; pfam09423
688245009010 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
688245009011 putative active site; other site
688245009012 putative metal binding site; other site
688245009013 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
688245009014 Phospholipase D. Active site motifs; The PLD superfamily includes enzymes involved in signal transduction, lipid biosynthesis, endonucleases and open reading frames in pathogenic viruses and bacteria. PLD hydrolyzes the terminal phosphodiester bond of...; Region: PLDc; cd00138
688245009015 active site
688245009016 signature motif; other site
688245009017 Phospholipase D. Active site motifs; The PLD superfamily includes enzymes involved in signal transduction, lipid biosynthesis, endonucleases and open reading frames in pathogenic viruses and bacteria. PLD hydrolyzes the terminal phosphodiester bond of...; Region: PLDc; cd00138
688245009018 active site
688245009019 signature motif; other site
688245009020 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
688245009021 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245009022 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
688245009023 methionine aminopeptidase; Reviewed; Region: PRK07281
688245009024 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
688245009025 active site
688245009026 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
688245009027 Predicted esterase [General function prediction only]; Region: COG0400
688245009028 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245009029 RF-1 domain; Region: RF-1; cl02875
688245009030 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
688245009031 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245009032 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
688245009033 trimer interface; other site
688245009034 active site
688245009035 dimer interface; other site
688245009036 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
688245009037 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
688245009038 HIGH motif; other site
688245009039 active site
688245009040 nucleotide binding site; other site
688245009041 catalytic core domain of non-descriminating glutamyl-tRNA and glutaminyl-tRNA synthetase; Region: Gln_GluRS_non_core; cd00807
688245009042 KMSKS motif; other site
688245009043 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
688245009044 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
688245009045 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
688245009046 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
688245009047 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
688245009048 Peptidase family M23; Region: Peptidase_M23; pfam01551
688245009049 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001
688245009050 META domain; Region: META; cl01245
688245009051 enterobactin exporter EntS; Provisional; Region: PRK10489
688245009052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245009053 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921
688245009054 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl12058
688245009055 Predicted permeases [General function prediction only]; Region: RarD; COG2962
688245009056 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130
688245009057 active site
688245009058 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404
688245009059 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
688245009060 Peptidase dimerization domain; Region: M20_dimer; cl09126
688245009061 PAS domain S-box; Region: sensory_box; TIGR00229
688245009062 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
688245009063 putative active site; other site
688245009064 heme pocket; other site
688245009065 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245009066 metal-binding site
688245009067 active site
688245009068 I-site; other site
688245009069 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
688245009070 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
688245009071 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases...; Region: YlqF; cd01856
688245009072 GTP/Mg2+ binding site; other site
688245009073 G4 box; other site
688245009074 G5 box; other site
688245009075 G1 box; other site
688245009076 Switch I region; other site
688245009077 G2 box; other site
688245009078 G3 box; other site
688245009079 Switch II region; other site
688245009080 Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791
688245009081 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
688245009082 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144
688245009083 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl01099
688245009084 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
688245009085 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245009086 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
688245009087 catalytic loop; other site
688245009088 iron binding site; other site
688245009089 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
688245009090 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
688245009091 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522
688245009092 dimerization interface; other site
688245009093 active site
688245009094 6,7-dimethyl-8-ribityllumazine synthase; Region: DMRL_synthase; cl00317
688245009095 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223
688245009096 putative RNA binding site; other site
688245009097 aspartate aminotransferase; Provisional; Region: PRK06108
688245009098 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688245009099 pyridoxal 5'-phosphate binding site; other site
688245009100 homodimer interface; other site
688245009101 catalytic residue; other site
688245009102 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586
688245009103 active site
688245009104 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
688245009105 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
688245009106 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
688245009107 Gram-negative bacterial tonB protein; Region: TonB; cl10048
688245009108 hypothetical protein; Reviewed; Region: PRK09588
688245009109 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032
688245009110 RF-1 domain; Region: RF-1; cl02875
688245009111 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245009112 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245009113 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245009114 dimerization interface; other site
688245009115 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
688245009116 Peptidase family U32; Region: Peptidase_U32; pfam01136
688245009117 Transcriptional regulator [Transcription]; Region: IclR; COG1414
688245009118 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245009119 Bacterial transcriptional regulator; Region: IclR; pfam01614
688245009120 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245009121 acyl-CoA synthetase; Validated; Region: PRK06188
688245009122 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245009123 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA)...; Region: CCL_ACL-C; cd06100
688245009124 active site
688245009125 oxalacetate binding site; other site
688245009126 citrylCoA binding site; other site
688245009127 coenzyme A binding site; other site
688245009128 catalytic triad; other site
688245009129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245009130 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
688245009131 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
688245009132 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245009133 N-terminal plug; other site
688245009134 ligand-binding site; other site
688245009135 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
688245009136 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
688245009137 potential frameshift: common BLAST hit: gi|160897882|ref|YP_001563464.1| aconitate hydratase
688245009138 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
688245009139 ligand binding site; other site
688245009140 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
688245009141 substrate binding site; other site
688245009142 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
688245009143 substrate binding site; other site
688245009144 CoA-transferase family III; Region: CoA_transf_3; cl00778
688245009145 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245009146 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
688245009147 Peptidase dimerization domain; Region: M20_dimer; cl09126
688245009148 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245009149 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245009150 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245009151 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
688245009152 active site
688245009153 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
688245009154 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245009155 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245009156 dimerization interface; other site
688245009157 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
688245009158 Sodium:solute symporter family; Region: SSF; cl00456
688245009159 Transcriptional regulators [Transcription]; Region: GntR; COG1802
688245009160 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245009161 DNA binding site
688245009162 FCD domain; Region: FCD; cl11656
688245009163 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
688245009164 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245009165 DNA binding site
688245009166 FCD domain; Region: FCD; cl11656
688245009167 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
688245009168 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061
688245009169 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
688245009170 Ferritin-like domain; Region: Ferritin; pfam00210
688245009171 heme binding site; other site
688245009172 ferroxidase pore; other site
688245009173 ferroxidase diiron center; other site
688245009174 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
688245009175 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
688245009176 non-specific DNA binding site; other site
688245009177 salt bridge; other site
688245009178 sequence-specific DNA binding site; other site
688245009179 FCD domain; Region: FCD; cl11656
688245009180 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342
688245009181 trimer interface; other site
688245009182 eyelet of channel; other site
688245009183 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245009184 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
688245009185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245009186 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245009187 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
688245009188 homotrimer interaction site; other site
688245009189 putative active site; other site
688245009190 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
688245009191 FAD binding domain; Region: FAD_binding_4; cl10516
688245009192 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245009193 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
688245009194 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change...; Region: AcnB_Swivel; cd01576
688245009195 substrate binding site; other site
688245009196 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
688245009197 substrate binding site; other site
688245009198 ligand binding site; other site
688245009199 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl09155
688245009200 trans-aconitate 2-methyltransferase; Provisional; Region: PRK01683
688245009201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
688245009202 S-adenosylmethionine binding site; other site
688245009203 malate dehydrogenase; Provisional; Region: PRK05442
688245009204 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
688245009205 NAD(P) binding site; other site
688245009206 dimer interface; other site
688245009207 malate binding site; other site
688245009208 Transcriptional regulators [Transcription]; Region: PhnF; COG2188
688245009209 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245009210 DNA binding site
688245009211 UTRA domain; Region: UTRA; cl06649
688245009212 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
688245009213 Iron-sulfur protein interface; other site
688245009214 proximal quinone binding site; other site
688245009215 SdhD (CybS) interface; other site
688245009216 proximal heme binding site; other site
688245009217 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
688245009218 SdhC subunit interface; other site
688245009219 proximal heme binding site; other site
688245009220 cardiolipin binding site; other site
688245009221 Iron-sulfur protein interface; other site
688245009222 proximal quinone binding site; other site
688245009223 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
688245009224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245009225 domain; Region: Succ_DH_flav_C; pfam02910
688245009226 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
688245009227 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
688245009228 dimer interface; other site
688245009229 Citrate synthase; Region: Citrate_synt; pfam00285
688245009230 active site
688245009231 citrylCoA binding site; other site
688245009232 NADH binding; other site
688245009233 cationic pore residues; other site
688245009234 oxalacetate/citrate binding site; other site
688245009235 coenzyme A binding site; other site
688245009236 catalytic triad; other site
688245009237 Quinone oxidoreductase (QOR); Region: QOR2; cd05286
688245009238 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
688245009239 NADP binding site; other site
688245009240 dimer interface; other site
688245009241 helicase 45; Provisional; Region: PTZ00424
688245009242 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268
688245009243 ATP binding site; other site
688245009244 Mg++ binding site; other site
688245009245 motif III; other site
688245009246 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
688245009247 nucleotide binding region; other site
688245009248 ATP-binding site; other site
688245009249 DNA helicase, putative; Region: TIGR00376
688245009250 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245009251 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
688245009252 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
688245009253 putative active site; other site
688245009254 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784
688245009255 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
688245009256 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
688245009257 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
688245009258 conserved cys residue; other site
688245009259 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
688245009260 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
688245009261 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
688245009262 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
688245009263 substrate binding site; other site
688245009264 catalytic Zn binding site; other site
688245009265 NAD binding site; other site
688245009266 structural Zn binding site; other site
688245009267 dimer interface; other site
688245009268 Predicted esterase [General function prediction only]; Region: COG0627
688245009269 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245009270 Uncharacterized conserved protein (DUF2132); Region: DUF2132; cl01894
688245009271 Cupin domain; Region: Cupin_2; cl09118
688245009272 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
688245009273 phenol 2-monooxygenase; Provisional; Region: PRK08294
688245009274 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245009275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245009276 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979
688245009277 dimer interface; other site
688245009278 Transcriptional regulators [Transcription]; Region: MarR; COG1846
688245009279 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245009280 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
688245009281 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
688245009282 motif II; other site
688245009283 phosphonate metabolism-associated iron-containing alcohol dehydrogenase; Region: Phn_Fe-ADH; TIGR03405
688245009284 Hydroxyethylphosphoate dehydrogenase (HEPD) catalyzes the reduction of phosphonoacetaldehyde (PnAA) to hydroxyethylphosphoate (HEP); Region: HEPD; cd08182
688245009285 putative active site; other site
688245009286 metal-binding site
688245009287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245009288 dimer interface; other site
688245009289 conserved gate region; other site
688245009290 putative PBP binding loops; other site
688245009291 ABC-ATPase subunit interface; other site
688245009292 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
688245009293 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256
688245009294 Walker A/P-loop; other site
688245009295 ATP binding site; other site
688245009296 Q-loop/lid; other site
688245009297 ABC transporter signature motif; other site
688245009298 Walker B; other site
688245009299 D-loop; other site
688245009300 H-loop/switch region; other site
688245009301 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245009302 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431
688245009303 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
688245009304 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245009305 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
688245009306 dimerization interface; other site
688245009307 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245009308 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
688245009309 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
688245009310 FeS/SAM binding site; other site
688245009311 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
688245009312 C-term; Region: GreA_GreB; pfam01272
688245009313 Predicted acyltransferases [Lipid metabolism]; Region: COG1835; cl00792
688245009314 Acyltransferase family; Region: Acyl_transf_3; pfam01757
688245009315 Predicted transcriptional regulators [Transcription]; Region: COG1510
688245009316 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
688245009317 dimerization interface; other site
688245009318 putative DNA binding site; other site
688245009319 putative Zn2+ binding site; other site
688245009320 Transcriptional regulators [Transcription]; Region: PurR; COG1609
688245009321 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
688245009322 DNA binding site
688245009323 domain linker motif; other site
688245009324 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
688245009325 putative ligand binding site; other site
688245009326 putative dimerization interface; other site
688245009327 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
688245009328 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265
688245009329 ATP-binding site; other site
688245009330 Gluconate-6-phosphate binding site; other site
688245009331 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
688245009332 DctM-like transporters; Region: DctM; pfam06808
688245009333 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688245009334 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710
688245009335 Dehydratase family; Region: ILVD_EDD; cl00340
688245009336 6-phosphogluconate dehydratase; Region: edd; TIGR01196
688245009337 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
688245009338 KDPG and KHG aldolase. This family belongs to the class I adolases whose reaction mechanism involves Schiff base formation between a substrate carbonyl and lysine residue in the active site. 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase, is best...; Region: KDPG_aldolase; cd00452
688245009339 active site
688245009340 intersubunit interface; other site
688245009341 catalytic residue; other site
688245009342 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
688245009343 cytochrome d oxidase, subunit II (cydB); Region: cydB; TIGR00203
688245009344 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
688245009345 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
688245009346 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
688245009347 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
688245009348 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245009349 Walker A/P-loop; other site
688245009350 ATP binding site; other site
688245009351 Q-loop/lid; other site
688245009352 ABC transporter signature motif; other site
688245009353 Walker B; other site
688245009354 D-loop; other site
688245009355 H-loop/switch region; other site
688245009356 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
688245009357 ABC transporter transmembrane region; Region: ABC_membrane; cl00549
688245009358 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with...; Region: ABCC_MRP_Like; cd03228
688245009359 Walker A/P-loop; other site
688245009360 ATP binding site; other site
688245009361 Q-loop/lid; other site
688245009362 ABC transporter signature motif; other site
688245009363 Walker B; other site
688245009364 D-loop; other site
688245009365 H-loop/switch region; other site
688245009366 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
688245009367 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730
688245009368 FMN binding site; other site
688245009369 substrate binding site; other site
688245009370 putative catalytic residue; other site
688245009371 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
688245009372 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
688245009373 putative ligand binding site; other site
688245009374 etfA (electron transfer flavoprotein alpha subunit); Provisional; Region: PLN00022
688245009375 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
688245009376 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
688245009377 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
688245009378 Ligand binding site; other site
688245009379 enoyl-CoA hydratase; Provisional; Region: PRK05980
688245009380 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
688245009381 substrate binding site; other site
688245009382 oxyanion hole (OAH) forming residues; other site
688245009383 trimer interface; other site
688245009384 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
688245009385 Histone deacetylase domain; Region: Hist_deacetyl; cl02986
688245009386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245009387 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
688245009388 Walker A motif; other site
688245009389 ATP binding site; other site
688245009390 Walker B motif; other site
688245009391 arginine finger; other site
688245009392 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245009393 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
688245009394 Protein of unknown function DUF58; Region: DUF58; pfam01882
688245009395 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
688245009396 Transglutaminase-like superfamily; Region: Transglut_core; cl10469
688245009397 lytic murein transglycosylase; Region: MltB_2; TIGR02283
688245009398 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254
688245009399 N-acetyl-D-glucosamine binding site; other site
688245009400 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
688245009401 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
688245009402 putative ligand binding site; other site
688245009403 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa...; Region: ACD_sHsps_p23-like; cd00298
688245009404 NADPH-dependent FMN reductase; Region: FMN_red; cl00438
688245009405 putative DNA-binding/iron metalloprotein/AP endonuclease; Reviewed; Region: PRK09604
688245009406 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
688245009407 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_10; cd04623
688245009408 FOG: CBS domain [General function prediction only]; Region: COG0517
688245009409 Uncharacterized conserved protein (DUF2302); Region: DUF2302; cl02237
688245009410 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342
688245009411 eyelet of channel; other site
688245009412 trimer interface; other site
688245009413 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245009414 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
688245009415 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
688245009416 NAD(P) binding site; other site
688245009417 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
688245009418 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245009419 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
688245009420 dimerization interface; other site
688245009421 substrate binding pocket; other site
688245009422 glycosyl transferase family protein; Provisional; Region: PRK08136
688245009423 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
688245009424 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
688245009425 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442
688245009426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245009427 flavoprotein, HI0933 family; Region: TIGR00275
688245009428 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
688245009429 putative ligand binding site; other site
688245009430 Ribosomal protein S21; Region: Ribosomal_S21; cl00529
688245009431 GatB domain; Region: GatB_Yqey; cl11497
688245009432 transcriptional activator TtdR; Provisional; Region: PRK09801
688245009433 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245009434 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
688245009435 putative effector binding pocket; other site
688245009436 putative dimerization interface; other site
688245009437 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
688245009438 Domain of unknown function (DU1801); Region: DUF1801; cl01838
688245009439 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
688245009440 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245009441 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245009442 dimerization interface; other site
688245009443 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245009444 galactarate dehydratase; Region: galactar-dH20; TIGR03248
688245009445 SAF domain; Region: SAF; cl00555
688245009446 SAF domain; Region: SAF; cl00555
688245009447 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
688245009448 tetramerization interface; other site
688245009449 NAD(P) binding site; other site
688245009450 catalytic residues; other site
688245009451 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
688245009452 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl09155
688245009453 cAMP phosphodiesterase; Provisional; Region: PRK11359
688245009454 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
688245009455 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
688245009456 putative active site; other site
688245009457 heme pocket; other site
688245009458 GAF domain; Region: GAF; cl00853
688245009459 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245009460 metal-binding site
688245009461 active site
688245009462 I-site; other site
688245009463 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
688245009464 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
688245009465 EamA-like transporter family; Region: EamA; cl01037
688245009466 Putative modulator of DNA gyrase; Region: PmbA_TldD; cl00398
688245009467 Protein of unknown function (DUF615); Region: DUF615; cl01147
688245009468 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886
688245009469 MPT binding site; other site
688245009470 trimer interface; other site
688245009471 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
688245009472 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
688245009473 putative ligand binding site; other site
688245009474 ThiC family; Region: ThiC; cl08031
688245009475 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a...; Region: Nitroreductase; cd02136
688245009476 putative FMN binding site; other site
688245009477 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
688245009478 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
688245009479 putative ligand binding site; other site
688245009480 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a...; Region: Nitroreductase; cd02136
688245009481 putative FMN binding site; other site
688245009482 serine O-acetyltransferase; Region: cysE; TIGR01172
688245009483 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L...; Region: LbH_SAT; cd03354
688245009484 trimer interface; other site
688245009485 active site
688245009486 substrate binding site; other site
688245009487 CoA binding site; other site
688245009488 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
688245009489 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
688245009490 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
688245009491 dimerization interface; other site
688245009492 active site
688245009493 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
688245009494 DNA mismatch repair protein MutS; Provisional; Region: PRK05399
688245009495 MutS domain I; Region: MutS_I; pfam01624
688245009496 MutS domain II; Region: MutS_II; pfam05188
688245009497 MutS domain III; Region: MutS_III; cl04977
688245009498 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245009499 Walker A/P-loop; other site
688245009500 ATP binding site; other site
688245009501 Q-loop/lid; other site
688245009502 ABC transporter signature motif; other site
688245009503 Walker B; other site
688245009504 D-loop; other site
688245009505 H-loop/switch region; other site
688245009506 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
688245009507 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
688245009508 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144
688245009509 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
688245009510 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings...; Region: proteasome_beta_bacterial; cd03765
688245009511 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
688245009512 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245009513 Bacitracin resistance protein BacA; Region: BacA; cl00858
688245009514 psiF repeat; Region: PsiF_repeat; pfam07769
688245009515 psiF repeat; Region: PsiF_repeat; pfam07769
688245009516 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
688245009517 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
688245009518 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245009519 N-terminal plug; other site
688245009520 ligand-binding site; other site
688245009521 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232
688245009522 Histidine kinase; Region: His_kinase; pfam06580
688245009523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
688245009524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245009525 active site
688245009526 phosphorylation site
688245009527 intermolecular recognition site; other site
688245009528 dimerization interface; other site
688245009529 LytTr DNA-binding domain; Region: LytTR; cl04498
688245009530 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245009531 Walker A/P-loop; other site
688245009532 ATP binding site; other site
688245009533 Q-loop/lid; other site
688245009534 ABC transporter signature motif; other site
688245009535 Walker B; other site
688245009536 D-loop; other site
688245009537 H-loop/switch region; other site
688245009538 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; cl10449
688245009539 NodT family; Region: outer_NodT; TIGR01845
688245009540 Outer membrane efflux protein; Region: OEP; pfam02321
688245009541 Outer membrane efflux protein; Region: OEP; pfam02321
688245009542 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
688245009543 Protein export membrane protein; Region: SecD_SecF; cl14618
688245009544 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
688245009545 Protein export membrane protein; Region: SecD_SecF; cl14618
688245009546 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
688245009547 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
688245009548 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; cl10449
688245009549 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370
688245009550 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
688245009551 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
688245009552 metal ion-dependent adhesion site (MIDAS); other site
688245009553 MoxR-like ATPases [General function prediction only]; Region: COG0714
688245009554 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
688245009555 FAD binding domain; Region: FAD_binding_4; cl10516
688245009556 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416
688245009557 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315
688245009558 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
688245009559 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
688245009560 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
688245009561 catalytic loop; other site
688245009562 iron binding site; other site
688245009563 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799
688245009564 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
688245009565 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
688245009566 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
688245009567 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
688245009568 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688245009569 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688245009570 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710
688245009571 potential frameshift: common BLAST hit: gi|89901645|ref|YP_524116.1| twin-arginine translocation pathway signal
688245009572 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710
688245009573 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710
688245009574 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
688245009575 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007
688245009576 TPP-binding site; other site
688245009577 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
688245009578 PYR/PP interface; other site
688245009579 dimer interface; other site
688245009580 TPP binding site; other site
688245009581 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
688245009582 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
688245009583 substrate binding pocket; other site
688245009584 chain length determination region; other site
688245009585 substrate-Mg2+ binding site; other site
688245009586 catalytic residues; other site
688245009587 aspartate-rich region 1; other site
688245009588 active site lid residues
688245009589 aspartate-rich region 2; other site
688245009590 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
688245009591 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
688245009592 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
688245009593 [2Fe-2S] cluster binding site; other site
688245009594 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
688245009595 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448
688245009596 active site residue
688245009597 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
688245009598 active site residue
688245009599 Flagellar transcriptional activator (FlhD); Region: FlhD; cl05012
688245009600 Flagellar transcriptional activator (FlhC); Region: FlhC; cl05036
688245009601 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
688245009602 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
688245009603 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
688245009604 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
688245009605 domain interfaces; other site
688245009606 active site
688245009607 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578
688245009608 active site
688245009609 HemX; Region: HemX; pfam04375
688245009610 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071
688245009611 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
688245009612 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
688245009613 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799
688245009614 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
688245009615 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
688245009616 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
688245009617 YceI-like domain; Region: YceI; cl01001
688245009618 YceI-like domain; Region: YceI; cl01001
688245009619 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
688245009620 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
688245009621 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
688245009622 HIGH motif; other site
688245009623 active site
688245009624 nucleotide binding site; other site
688245009625 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
688245009626 active site
688245009627 KMSKS motif; other site
688245009628 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
688245009629 tRNA binding surface; other site
688245009630 anticodon binding site; other site
688245009631 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
688245009632 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
688245009633 active site
688245009634 tetramer interface; other site
688245009635 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two...; Region: SirA_YedF_YeeD; cd00291
688245009636 CPxP motif; other site
688245009637 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
688245009638 putative NADH binding site; other site
688245009639 putative active site; other site
688245009640 nudix motif; other site
688245009641 putative metal binding site; other site
688245009642 cysteine synthases; Region: cysKM; TIGR01136
688245009643 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561
688245009644 dimer interface; other site
688245009645 pyridoxal 5'-phosphate binding site; other site
688245009646 catalytic residue; other site
688245009647 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA...; Region: S24_LexA-like; cd06529
688245009648 Catalytic site; other site
688245009649 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
688245009650 umuC subunit of DNA Polymerase V; Region: Pol_V_umuC; cd01700
688245009651 active site
688245009652 DNA binding site
688245009653 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
688245009654 catalytic residues; other site
688245009655 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
688245009656 NlpC/P60 family; Region: NLPC_P60; cl11438
688245009657 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
688245009658 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218
688245009659 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
688245009660 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268
688245009661 Phage-related minor tail protein [Function unknown]; Region: COG5281
688245009662 Prophage tail length tape measure protein; Region: TMP_2; pfam06791
688245009663 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541
688245009664 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
688245009665 Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809
688245009666 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl00287
688245009667 Uncharacterized conserved protein (DUF2190); Region: DUF2190; cl02289
688245009668 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
688245009669 oligomer interface; other site
688245009670 active site residues
688245009671 Bacteriophage capsid protein [General function prediction only]; Region: COG5511
688245009672 Protein of unknown function (DUF2610); Region: DUF2610; pfam11020
688245009673 Mor transcription activator family; Region: Mor; cl02360
688245009674 Protein of unknown function (DUF2481); Region: DUF2481; cl05448
688245009675 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
688245009676 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720
688245009677 Protein of unknown function (DUF1376); Region: DUF1376; cl01531
688245009678 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892
688245009679 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
688245009680 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
688245009681 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88)...; Region: Peptidase_S24_S26; cd06462
688245009682 Catalytic site; other site
688245009683 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
688245009684 Core-2/I-Branching enzyme; Region: Branch; pfam02485
688245009685 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside...; Region: NK; cl11962
688245009686 active site
688245009687 restriction alleviation and modification protein; Reviewed; Region: lar; cl08047
688245009688 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
688245009689 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl01302
688245009690 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450
688245009691 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
688245009692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245009693 active site
688245009694 phosphorylation site
688245009695 intermolecular recognition site; other site
688245009696 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
688245009697 DNA binding residues
688245009698 dimerization interface; other site
688245009699 LrgA family; Region: LrgA; cl00608
688245009700 LrgB-like family; Region: LrgB; cl00596
688245009701 EamA-like transporter family; Region: EamA; cl01037
688245009702 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245009703 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245009704 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
688245009705 putative effector binding pocket; other site
688245009706 dimerization interface; other site
688245009707 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl00527
688245009708 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
688245009709 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245009710 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245009711 dimerization interface; other site
688245009712 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
688245009713 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
688245009714 FAD binding site; other site
688245009715 substrate binding pocket; other site
688245009716 catalytic base; other site
688245009717 CoA-transferase family III; Region: CoA_transf_3; cl00778
688245009718 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245009719 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342
688245009720 eyelet of channel; other site
688245009721 trimer interface; other site
688245009722 sugar efflux transporter; Provisional; Region: PRK03545
688245009723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245009724 putative substrate translocation pore; other site
688245009725 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245009726 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10632
688245009727 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245009728 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
688245009729 putative effector binding pocket; other site
688245009730 dimerization interface; other site
688245009731 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
688245009732 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
688245009733 dimerization interface; other site
688245009734 ligand binding site; other site
688245009735 6,7-dimethyl-8-ribityllumazine synthase; Region: DMRL_synthase; cl00317
688245009736 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
688245009737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245009738 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
688245009739 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
688245009740 catalytic loop; other site
688245009741 iron binding site; other site
688245009742 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD...; Region: flavin_oxioreductase; cd06189
688245009743 FAD binding pocket; other site
688245009744 FAD binding motif; other site
688245009745 phosphate binding motif; other site
688245009746 beta-alpha-beta structure motif; other site
688245009747 NAD binding pocket; other site
688245009748 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245009749 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
688245009750 catalytic center binding site; other site
688245009751 ATP binding site; other site
688245009752 poly(A) polymerase; Region: pcnB; TIGR01942
688245009753 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
688245009754 active site
688245009755 NTP binding site; other site
688245009756 metal binding triad; metal-binding site
688245009757 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
688245009758 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245009759 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
688245009760 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196
688245009761 dimerization interface; other site
688245009762 putative ATP binding site; other site
688245009763 Domain of unknown function DUF20; Region: UPF0118; cl00465
688245009764 putative transcriptional regulator; Provisional; Region: PRK10941
688245009765 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
688245009766 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
688245009767 Predicted dehydrogenase [General function prediction only]; Region: COG0579
688245009768 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245009769 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
688245009770 MatE; Region: MatE; pfam01554
688245009771 MatE; Region: MatE; pfam01554
688245009772 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
688245009773 acetylornithine aminotransferase; Provisional; Region: PRK02627
688245009774 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
688245009775 inhibitor-cofactor binding pocket; inhibition site
688245009776 pyridoxal 5'-phosphate binding site; other site
688245009777 catalytic residue; other site
688245009778 ornithine carbamoyltransferase; Provisional; Region: PRK00779
688245009779 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
688245009780 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
688245009781 Uncharacterized protein family (UPF0153); Region: UPF0153; cl00497
688245009782 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
688245009783 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879
688245009784 G1 box; other site
688245009785 GTP/Mg2+ binding site; other site
688245009786 Switch I region; other site
688245009787 G2 box; other site
688245009788 G3 box; other site
688245009789 Switch II region; other site
688245009790 G4 box; other site
688245009791 G5 box; other site
688245009792 Nucleoside recognition; Region: Gate; cl00486
688245009793 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
688245009794 Nucleoside recognition; Region: Gate; cl00486
688245009795 FeoA domain; Region: FeoA; cl00838
688245009796 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
688245009797 Protein phosphatase 2C; Region: PP2C; pfam00481
688245009798 active site
688245009799 LysE type translocator; Region: LysE; cl00565
688245009800 Cupin domain; Region: Cupin_2; cl09118
688245009801 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
688245009802 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
688245009803 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
688245009804 ethanolamine permease; Region: 2A0305; TIGR00908
688245009805 Putative cyclase; Region: Cyclase; cl00814
688245009806 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
688245009807 kynureninase; Region: kynureninase; TIGR01814
688245009808 L-lactate permease; Region: Lactate_perm; cl00701
688245009809 L-lactate permease; Region: Lactate_perm; cl00701
688245009810 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
688245009811 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
688245009812 non-specific DNA binding site; other site
688245009813 salt bridge; other site
688245009814 sequence-specific DNA binding site; other site
688245009815 Cupin domain; Region: Cupin_2; cl09118
688245009816 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl11430
688245009817 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl11430
688245009818 helix-hairpin-helix signature motif; other site
688245009819 substrate binding pocket; other site
688245009820 active site
688245009821 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
688245009822 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
688245009823 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
688245009824 DNA binding site
688245009825 active site
688245009826 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994
688245009827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245009828 Major Facilitator Superfamily; Region: MFS_1; pfam07690
688245009829 putative substrate translocation pore; other site
688245009830 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
688245009831 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245009832 H-NS histone family; Region: Histone_HNS; pfam00816
688245009833 Domain in histone-like proteins of HNS family; Region: HNS; cl09251
688245009834 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
688245009835 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
688245009836 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
688245009837 active site
688245009838 metal-binding site
688245009839 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268
688245009840 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
688245009841 ATP binding site; other site
688245009842 Mg++ binding site; other site
688245009843 motif III; other site
688245009844 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
688245009845 nucleotide binding region; other site
688245009846 ATP-binding site; other site
688245009847 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988
688245009848 ornithine cyclodeaminase; Validated; Region: PRK07340
688245009849 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
688245009850 NAD(P) binding site; other site
688245009851 Quinolinate synthetase A protein; Region: NadA; cl00420
688245009852 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245009853 domain; Region: Succ_DH_flav_C; pfam02910
688245009854 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
688245009855 trimer interface; other site
688245009856 active site
688245009857 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
688245009858 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
688245009859 active site
688245009860 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
688245009861 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
688245009862 dimerization interface; other site
688245009863 substrate binding pocket; other site
688245009864 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184
688245009865 substrate binding pocket; other site
688245009866 active site
688245009867 iron coordination sites; other site
688245009868 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
688245009869 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
688245009870 phosphate binding site; other site
688245009871 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life...; Region: HINT_subgroup; cd01277
688245009872 HIT family signature motif; other site
688245009873 catalytic residue; other site
688245009874 adenosine deaminase; Provisional; Region: PRK09358
688245009875 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
688245009876 active site
688245009877 purine riboside binding site; other site
688245009878 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
688245009879 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
688245009880 [2Fe-2S] cluster binding site; other site
688245009881 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
688245009882 putative ligand binding site; other site
688245009883 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
688245009884 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
688245009885 putative ligand binding site; other site
688245009886 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette...; Region: TM_PBP1_transp_TpRbsC_like; cd06580
688245009887 TM-ABC transporter signature motif; other site
688245009888 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette...; Region: TM_PBP1_transp_TpRbsC_like; cd06580
688245009889 TM-ABC transporter signature motif; other site
688245009890 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
688245009891 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216
688245009892 Walker A/P-loop; other site
688245009893 ATP binding site; other site
688245009894 Q-loop/lid; other site
688245009895 ABC transporter signature motif; other site
688245009896 Walker B; other site
688245009897 D-loop; other site
688245009898 H-loop/switch region; other site
688245009899 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_II; cd03215
688245009900 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
688245009901 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245009902 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245009903 dimerization interface; other site
688245009904 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
688245009905 putative active site; other site
688245009906 heme pocket; other site
688245009907 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245009908 metal-binding site
688245009909 active site
688245009910 I-site; other site
688245009911 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
688245009912 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245009913 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
688245009914 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245009915 N-terminal plug; other site
688245009916 ligand-binding site; other site
688245009917 fec operon regulator FecR; Reviewed; Region: PRK09774
688245009918 FecR protein; Region: FecR; pfam04773
688245009919 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
688245009920 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
688245009921 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055
688245009922 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
688245009923 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245009924 N-terminal plug; other site
688245009925 ligand-binding site; other site
688245009926 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
688245009927 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
688245009928 putative ligand binding residues; other site
688245009929 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
688245009930 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
688245009931 Walker A/P-loop; other site
688245009932 ATP binding site; other site
688245009933 Q-loop/lid; other site
688245009934 ABC transporter signature motif; other site
688245009935 Walker B; other site
688245009936 D-loop; other site
688245009937 H-loop/switch region; other site
688245009938 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462
688245009939 ABC-ATPase subunit interface; other site
688245009940 dimer interface; other site
688245009941 putative PBP binding regions; other site
688245009942 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
688245009943 ABC-ATPase subunit interface; other site
688245009944 dimer interface; other site
688245009945 putative PBP binding regions; other site
688245009946 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
688245009947 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245009948 Walker A/P-loop; other site
688245009949 ATP binding site; other site
688245009950 Q-loop/lid; other site
688245009951 ABC transporter signature motif; other site
688245009952 Walker B; other site
688245009953 D-loop; other site
688245009954 H-loop/switch region; other site
688245009955 potential frameshift: common BLAST hit: gi|26989315|ref|NP_744740.1| ABC transporter, permease/ATP-binding protein, putative
688245009956 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245009957 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
688245009958 Walker A/P-loop; other site
688245009959 ATP binding site; other site
688245009960 Q-loop/lid; other site
688245009961 ABC transporter signature motif; other site
688245009962 Walker B; other site
688245009963 D-loop; other site
688245009964 H-loop/switch region; other site
688245009965 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
688245009966 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
688245009967 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
688245009968 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
688245009969 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
688245009970 Protein of unknown function (DUF989); Region: DUF989; pfam06181
688245009971 Cytochrome c; Region: Cytochrom_C; cl11414
688245009972 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
688245009973 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
688245009974 Family of unknown function (DUF500); Region: DUF500; cl01109
688245009975 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU)...; Region: TLP_HIUase; cd05822
688245009976 active site
688245009977 homotetramer interface; other site
688245009978 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
688245009979 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
688245009980 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505
688245009981 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
688245009982 glyoxylate carboligase; Provisional; Region: PRK11269
688245009983 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
688245009984 PYR/PP interface; other site
688245009985 dimer interface; other site
688245009986 TPP binding site; other site
688245009987 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
688245009988 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629
688245009989 TPP-binding site; other site
688245009990 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10632
688245009991 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245009992 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
688245009993 putative effector binding pocket; other site
688245009994 dimerization interface; other site
688245009995 MOFRL family; Region: MOFRL; cl01013
688245009996 potential frameshift: common BLAST hit: gi|160897554|ref|YP_001563136.1| GntR family transcriptional regulator
688245009997 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245009998 DNA binding site
688245009999 FCD domain; Region: FCD; cl11656
688245010000 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
688245010001 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061
688245010002 putative bifunctional OHCU decarboxylase/allantoate amidohydrolase; Provisional; Region: PRK13590
688245010003 OHCU decarboxylase; Region: OHCU_decarbox; cl01251
688245010004 Peptidase dimerization domain; Region: M20_dimer; cl09126
688245010005 Peptidase dimerization domain; Region: M20_dimer; cl09126
688245010006 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651
688245010007 Peptidase dimerization domain; Region: M20_dimer; cl09126
688245010008 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10632
688245010009 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245010010 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245010011 dimerization interface; other site
688245010012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245010013 putative substrate translocation pore; other site
688245010014 Major Facilitator Superfamily; Region: MFS_1; pfam07690
688245010015 Permease family; Region: Xan_ur_permease; cl00967
688245010016 malic enzyme; Reviewed; Region: PRK07232
688245010017 Malic enzyme, N-terminal domain; Region: malic; pfam00390
688245010018 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
688245010019 putative NAD(P) binding site; other site
688245010020 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
688245010021 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
688245010022 Sel1 repeat; Region: Sel1; cl02723
688245010023 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
688245010024 non-specific DNA binding site; other site
688245010025 salt bridge; other site
688245010026 sequence-specific DNA binding site; other site
688245010027 insertion element IS2 transposase InsD; Reviewed; Region: PRK09409
688245010028 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
688245010029 alanyl-tRNA synthetase; Region: PLN02900
688245010030 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
688245010031 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245010032 Walker A motif; other site
688245010033 ATP binding site; other site
688245010034 Walker B motif; other site
688245010035 arginine finger; other site
688245010036 DoxX; Region: DoxX; cl00976
688245010037 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
688245010038 EamA-like transporter family; Region: EamA; cl01037
688245010039 Pirin-related protein [General function prediction only]; Region: COG1741
688245010040 Cupin domain; Region: Cupin_2; cl09118
688245010041 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
688245010042 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245010043 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245010044 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
688245010045 putative effector binding pocket; other site
688245010046 putative dimerization interface; other site
688245010047 NodT family; Region: outer_NodT; TIGR01845
688245010048 Outer membrane efflux protein; Region: OEP; pfam02321
688245010049 Outer membrane efflux protein; Region: OEP; pfam02321
688245010050 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
688245010051 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
688245010052 Walker A/P-loop; other site
688245010053 ATP binding site; other site
688245010054 Q-loop/lid; other site
688245010055 ABC transporter signature motif; other site
688245010056 Walker B; other site
688245010057 D-loop; other site
688245010058 H-loop/switch region; other site
688245010059 Predicted permease; Region: FtsX; cl11418
688245010060 macrolide transporter subunit MacA; Provisional; Region: PRK11578
688245010061 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
688245010062 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
688245010063 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
688245010064 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245010065 N-terminal plug; other site
688245010066 ligand-binding site; other site
688245010067 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245010068 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
688245010069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245010070 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214
688245010071 intersubunit interface; other site
688245010072 active site
688245010073 Zn2+ binding site; other site
688245010074 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
688245010075 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245010076 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245010077 etfA (electron transfer flavoprotein alpha subunit); Provisional; Region: PLN00022
688245010078 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
688245010079 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
688245010080 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
688245010081 Ligand binding site; other site
688245010082 putative enoyl-(acyl-carrier-protein) reductase II; Region: enACPred_II; TIGR03151
688245010083 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730
688245010084 FMN binding site; other site
688245010085 substrate binding site; other site
688245010086 putative catalytic residue; other site
688245010087 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245010088 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245010089 CoA-transferase family III; Region: CoA_transf_3; cl00778
688245010090 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
688245010091 enoyl-CoA hydratase; Provisional; Region: PRK06142
688245010092 substrate binding site; other site
688245010093 oxyanion hole (OAH) forming residues; other site
688245010094 trimer interface; other site
688245010095 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
688245010096 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
688245010097 Acyl-CoA dehydrogenase; Region: ACAD; cd00567
688245010098 active site
688245010099 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
688245010100 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245010101 active site
688245010102 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
688245010103 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
688245010104 dimer interface; other site
688245010105 active site
688245010106 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
688245010107 substrate binding site; other site
688245010108 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
688245010109 oxyanion hole (OAH) forming residues; other site
688245010110 trimer interface; other site
688245010111 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245010112 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
688245010113 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
688245010114 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245010115 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245010116 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
688245010117 putative effector binding pocket; other site
688245010118 dimerization interface; other site
688245010119 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
688245010120 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184
688245010121 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
688245010122 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl01276
688245010123 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
688245010124 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
688245010125 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
688245010126 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799
688245010127 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
688245010128 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
688245010129 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
688245010130 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
688245010131 potential frameshift: common BLAST hit: gi|160899363|ref|YP_001564945.1| gluconate 2-dehydrogenase (acceptor)
688245010132 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
688245010133 Cytochrome c; Region: Cytochrom_C; cl11414
688245010134 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
688245010135 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
688245010136 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
688245010137 aspartate racemase; Region: asp_race; TIGR00035
688245010138 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
688245010139 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
688245010140 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091
688245010141 active site
688245010142 substrate binding site; other site
688245010143 Mg2+ binding site; other site
688245010144 Transcriptional regulators [Transcription]; Region: PhnF; COG2188
688245010145 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245010146 DNA binding site
688245010147 UTRA domain; Region: UTRA; cl06649
688245010148 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245010149 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394
688245010150 fumarylacetoacetase; Region: PLN02856
688245010151 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
688245010152 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
688245010153 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
688245010154 Sporulation related domain; Region: SPOR; cl10051
688245010155 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
688245010156 coproporphyrinogen III oxidase; Provisional; Region: PRK08898
688245010157 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
688245010158 FeS/SAM binding site; other site
688245010159 HemN C-terminal region; Region: HemN_C; pfam06969
688245010160 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515
688245010161 active site
688245010162 dimerization interface; other site
688245010163 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
688245010164 Protein phosphatase 2C; Region: PP2C; pfam00481
688245010165 active site
688245010166 Protein kinase domain; Region: Pkinase; pfam00069
688245010167 Catalytic domain of Protein Kinases; Region: PKc; cd00180
688245010168 active site
688245010169 ATP binding site; other site
688245010170 substrate binding site; other site
688245010171 activation loop (A-loop); other site
688245010172 hypothetical protein; Provisional; Region: PRK11820
688245010173 YicC-like family, N-terminal region; Region: YicC_N; pfam03755
688245010174 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
688245010175 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071
688245010176 catalytic site; other site
688245010177 G-X2-G-X-G-K; other site
688245010178 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl00765
688245010179 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
688245010180 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
688245010181 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
688245010182 synthetase active site; other site
688245010183 NTP binding site; other site
688245010184 metal-binding site
688245010185 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668
688245010186 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
688245010187 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222
688245010188 lytic murein transglycosylase; Region: MltB_2; TIGR02283
688245010189 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
688245010190 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
688245010191 domain; Region: GreA_GreB_N; pfam03449
688245010192 C-term; Region: GreA_GreB; pfam01272
688245010193 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245010194 DNA binding site
688245010195 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
688245010196 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688245010197 pyridoxal 5'-phosphate binding site; other site
688245010198 homodimer interface; other site
688245010199 catalytic residue; other site
688245010200 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
688245010201 Amino acid permease; Region: AA_permease; pfam00324
688245010202 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
688245010203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245010204 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
688245010205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245010206 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
688245010207 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
688245010208 substrate binding pocket; other site
688245010209 membrane-bound complex binding site; other site
688245010210 hinge residues; other site
688245010211 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525
688245010212 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
688245010213 Walker A/P-loop; other site
688245010214 ATP binding site; other site
688245010215 Q-loop/lid; other site
688245010216 ABC transporter signature motif; other site
688245010217 Walker B; other site
688245010218 D-loop; other site
688245010219 H-loop/switch region; other site
688245010220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245010221 dimer interface; other site
688245010222 conserved gate region; other site
688245010223 putative PBP binding loops; other site
688245010224 ABC-ATPase subunit interface; other site
688245010225 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
688245010226 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
688245010227 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
688245010228 metal ion-dependent adhesion site (MIDAS); other site
688245010229 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
688245010230 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
688245010231 Transcriptional regulator [Transcription]; Region: IclR; COG1414
688245010232 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245010233 Bacterial transcriptional regulator; Region: IclR; pfam01614
688245010234 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525
688245010235 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
688245010236 PYR/PP interface; other site
688245010237 dimer interface; other site
688245010238 TPP binding site; other site
688245010239 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
688245010240 TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the desulfonation of 2-sulfoacetaldehyde into sulfite and acetyl...; Region: TPP_Xsc_like; cd02013
688245010241 TPP-binding site; other site
688245010242 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
688245010243 insertion element IS2 transposase InsD; Reviewed; Region: PRK09409
688245010244 Integrase core domain; Region: rve; cl01316
688245010245 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
688245010246 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
688245010247 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
688245010248 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
688245010249 catalytic residues; other site
688245010250 catalytic nucleophile; other site
688245010251 Presynaptic Site I dimer interface; other site
688245010252 Synaptic Antiparallel dimer interface; other site
688245010253 Synaptic Flat tetramer interface; other site
688245010254 Synaptic Site I dimer interface; other site
688245010255 DNA binding site
688245010256 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
688245010257 Int/Topo IB signature motif; other site
688245010258 active site
688245010259 DNA binding site
688245010260 seryl-tRNA synthetase; Provisional; Region: PRK05431
688245010261 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
688245010262 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
688245010263 dimer interface; other site
688245010264 active site
688245010265 motif 1; other site
688245010266 motif 2; other site
688245010267 motif 3; other site
688245010268 LytB protein; Region: LYTB; cl00507
688245010269 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
688245010270 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
688245010271 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
688245010272 DNA repair protein RadC; Reviewed; Region: radC; PRK00024
688245010273 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
688245010274 MPN+ (JAMM) motif; other site
688245010275 Zinc-binding site; other site
688245010276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
688245010277 Smr domain; Region: Smr; cl02619
688245010278 Peptidase family M48; Region: Peptidase_M48; cl12018
688245010279 LemA family; Region: LemA; cl00742
688245010280 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
688245010281 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
688245010282 active site
688245010283 metal-binding site
688245010284 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
688245010285 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454
688245010286 apolar tunnel; other site
688245010287 heme binding site; other site
688245010288 dimerization interface; other site
688245010289 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
688245010290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245010291 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10632
688245010292 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245010293 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476
688245010294 putative effector binding pocket; other site
688245010295 putative dimerization interface; other site
688245010296 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
688245010297 Predicted permease; Region: FtsX; cl11418
688245010298 Sulfite exporter TauE/SafE; Region: TauE; cl00498
688245010299 adenosine deaminase; Provisional; Region: PRK09358
688245010300 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
688245010301 active site
688245010302 Low molecular weight phosphatase family; Region: LMWPc; cd00115
688245010303 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
688245010304 active site
688245010305 Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252
688245010306 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
688245010307 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
688245010308 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
688245010309 homotrimer interaction site; other site
688245010310 putative active site; other site
688245010311 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
688245010312 Amino acid permease; Region: AA_permease; pfam00324
688245010313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245010314 FAD dependent oxidoreductase; Region: DAO; pfam01266
688245010315 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
688245010316 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
688245010317 EamA-like transporter family; Region: EamA; cl01037
688245010318 EamA-like transporter family; Region: EamA; cl01037
688245010319 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
688245010320 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
688245010321 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
688245010322 catalytic loop; other site
688245010323 iron binding site; other site
688245010324 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
688245010325 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl00255
688245010326 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H)...; Region: MopB_Formate-Dh-H; cd02753
688245010327 [4Fe-4S] binding site; other site
688245010328 molybdopterin cofactor binding site; other site
688245010329 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of...; Region: MopB_CT_Fdh-Nap-like; cd00508
688245010330 molybdopterin cofactor binding site; other site
688245010331 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958
688245010332 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
688245010333 putative dimer interface; other site
688245010334 [2Fe-2S] cluster binding site; other site
688245010335 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
688245010336 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
688245010337 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
688245010338 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl11430
688245010339 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
688245010340 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245010341 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245010342 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
688245010343 dimerization interface; other site
688245010344 putative ATPase; Provisional; Region: PRK11670
688245010345 Domain of unknown function DUF59; Region: DUF59; cl00941
688245010346 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
688245010347 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
688245010348 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
688245010349 nucleophile elbow; other site
688245010350 Cache domain; Region: Cache_1; pfam02743
688245010351 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
688245010352 dimerization interface; other site
688245010353 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245010354 metal-binding site
688245010355 active site
688245010356 I-site; other site
688245010357 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
688245010358 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
688245010359 active site
688245010360 HIGH motif; other site
688245010361 KMSKS motif; other site
688245010362 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
688245010363 tRNA binding surface; other site
688245010364 anticodon binding site; other site
688245010365 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
688245010366 dimer interface; other site
688245010367 putative tRNA-binding site; other site
688245010368 Cytochrome c; Region: Cytochrom_C; cl11414
688245010369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245010370 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
688245010371 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
688245010372 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
688245010373 Predicted secreted protein [Function unknown]; Region: COG5501; cl02313
688245010374 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
688245010375 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
688245010376 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
688245010377 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943
688245010378 ScpA/B protein; Region: ScpA_ScpB; cl00598
688245010379 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
688245010380 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
688245010381 FeS/SAM binding site; other site
688245010382 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263
688245010383 active site
688245010384 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342
688245010385 trimer interface; other site
688245010386 eyelet of channel; other site
688245010387 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
688245010388 tetramerization interface; other site
688245010389 active site
688245010390 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
688245010391 putative substrate binding pocket; other site
688245010392 trimer interface; other site
688245010393 DTW domain; Region: DTW; cl01221
688245010394 Predicted membrane protein [Function unknown]; Region: COG4682
688245010395 yiaA/B two helix domain; Region: YiaAB; cl01759
688245010396 yiaA/B two helix domain; Region: YiaAB; cl01759
688245010397 potential frameshift: common BLAST hit: gi|120612490|ref|YP_972168.1| para-aminobenzoate synthase, subunit I
688245010398 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224
688245010399 substrate-cofactor binding pocket; other site
688245010400 homodimer interface; other site
688245010401 pyridoxal 5'-phosphate binding site; other site
688245010402 catalytic residue; other site
688245010403 aminodeoxychorismate synthase; Provisional; Region: PRK07508
688245010404 chorismate binding enzyme; Region: Chorismate_bind; cl10555
688245010405 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
688245010406 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
688245010407 active site
688245010408 oligomerization interface; other site
688245010409 metal-binding site
688245010410 Pantoate-beta-alanine ligase; Region: PanC; cd00560
688245010411 pantoate--beta-alanine ligase; Region: panC; TIGR00018
688245010412 active site
688245010413 ATP-binding site; other site
688245010414 pantoate-binding site; other site
688245010415 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
688245010416 putative active site; other site
688245010417 putative catalytic site; other site
688245010418 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
688245010419 Permease family; Region: Xan_ur_permease; cl00967
688245010420 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
688245010421 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
688245010422 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245010423 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245010424 dimerization interface; other site
688245010425 diaminopimelate decarboxylase; Provisional; Region: PRK11165
688245010426 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
688245010427 active site
688245010428 pyridoxal 5'-phosphate (PLP) binding site; other site
688245010429 substrate binding site; other site
688245010430 catalytic residues; other site
688245010431 dimer interface; other site
688245010432 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
688245010433 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
688245010434 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245010435 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
688245010436 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251
688245010437 SecA binding site; other site
688245010438 Preprotein binding site; other site
688245010439 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
688245010440 GSH binding site; other site
688245010441 catalytic residues; other site
688245010442 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
688245010443 active site residue
688245010444 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
688245010445 catalytic core; other site
688245010446 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
688245010447 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
688245010448 C-terminal peptidase (prc); Region: prc; TIGR00225
688245010449 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
688245010450 protein binding site; other site
688245010451 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
688245010452 Catalytic dyad; other site
688245010453 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
688245010454 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757
688245010455 ATP binding site; other site
688245010456 substrate interface; other site
688245010457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245010458 active site
688245010459 phosphorylation site
688245010460 intermolecular recognition site; other site
688245010461 dimerization interface; other site
688245010462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245010463 active site
688245010464 phosphorylation site
688245010465 intermolecular recognition site; other site
688245010466 dimerization interface; other site
688245010467 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
688245010468 DNA binding residues
688245010469 dimerization interface; other site
688245010470 CHASE3 domain; Region: CHASE3; cl05000
688245010471 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
688245010472 Histidine kinase; Region: HisKA_3; pfam07730
688245010473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245010474 ATP binding site; other site
688245010475 Mg2+ binding site; other site
688245010476 G-X-G motif; other site
688245010477 Putative phospholipid-binding domain; Region: BON; cl02771
688245010478 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; cl09206
688245010479 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057
688245010480 Phosphopantetheine adenylyltransferase; Region: PPAT_a; cd02163
688245010481 active site
688245010482 substrate binding site; other site
688245010483 active site motif
688245010484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245010485 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
688245010486 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
688245010487 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
688245010488 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
688245010489 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
688245010490 Signal recognition particle GTPase [Intracellular trafficking and secretion]; Region: FtsY; COG0552
688245010491 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
688245010492 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras; Region: Ras_like_GTPase; cl10444
688245010493 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
688245010494 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
688245010495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245010496 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
688245010497 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
688245010498 NAD(P) binding site; other site
688245010499 catalytic residues; other site
688245010500 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
688245010501 Dihydrodipicolinate synthase family. A member of the class I aldolases, which use an active-site lysine which stablilzes a reaction intermediate via Schiff base formation, and have TIM beta/alpha barrel fold. The dihydrodipicolinate synthase family...; Region: DHDPS-like; cd00408
688245010502 inhibitor site; inhibition site
688245010503 active site
688245010504 dimer interface; other site
688245010505 catalytic residue; other site
688245010506 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
688245010507 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved...; Region: MR_like_2; cd03327
688245010508 putative active site pocket; other site
688245010509 putative metal binding site; other site
688245010510 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
688245010511 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
688245010512 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245010513 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
688245010514 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245010515 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245010516 dimerization interface; other site
688245010517 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10632
688245010518 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245010519 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475
688245010520 putative effector binding pocket; other site
688245010521 putative dimerization interface; other site
688245010522 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
688245010523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245010524 putative substrate translocation pore; other site
688245010525 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245010526 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
688245010527 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl01276
688245010528 Transcriptional regulators [Transcription]; Region: GntR; COG1802
688245010529 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245010530 DNA binding site
688245010531 FCD domain; Region: FCD; cl11656
688245010532 Dehydratase family; Region: ILVD_EDD; cl00340
688245010533 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110
688245010534 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474
688245010535 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245010536 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245010537 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245010538 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
688245010539 putative dimerization interface; other site
688245010540 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
688245010541 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
688245010542 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055
688245010543 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245010544 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
688245010545 Fatty acid desaturase; Region: FA_desaturase; pfam00487
688245010546 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816
688245010547 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by...; Region: init_cond_enzymes; cd00827
688245010548 dimer interface; other site
688245010549 active site
688245010550 Protein of unknown function (DUF3532); Region: DUF3532; pfam12050
688245010551 PAS domain S-box; Region: sensory_box; TIGR00229
688245010552 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
688245010553 putative active site; other site
688245010554 heme pocket; other site
688245010555 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245010556 metal-binding site
688245010557 active site
688245010558 I-site; other site
688245010559 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
688245010560 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
688245010561 Cu(I) binding site; other site
688245010562 UbiA prenyltransferase family; Region: UbiA; cl00337
688245010563 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
688245010564 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
688245010565 Subunit III/VIIa interface; other site
688245010566 Phospholipid binding site; other site
688245010567 Subunit I/III interface; other site
688245010568 Subunit III/VIb interface; other site
688245010569 Subunit III/VIa interface; other site
688245010570 Subunit III/Vb interface; other site
688245010571 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
688245010572 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240
688245010573 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
688245010574 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
688245010575 Subunit I/III interface; other site
688245010576 D-pathway; other site
688245010577 Subunit I/VIIc interface; other site
688245010578 Subunit I/IV interface; other site
688245010579 Subunit I/II interface; other site
688245010580 Low-spin heme (heme a) binding site; other site
688245010581 Subunit I/VIIa interface; other site
688245010582 Subunit I/VIa interface; other site
688245010583 Dimer interface; other site
688245010584 Putative water exit pathway; other site
688245010585 Binuclear center (heme a3/CuB); other site
688245010586 K-pathway; other site
688245010587 Subunit I/Vb interface; other site
688245010588 Putative proton exit pathway; other site
688245010589 Subunit I/VIb interface; other site
688245010590 Subunit I/VIc interface; other site
688245010591 Electron transfer pathway; other site
688245010592 Subunit I/VIIIb interface; other site
688245010593 Subunit I/VIIb interface; other site
688245010594 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140
688245010595 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
688245010596 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl10078
688245010597 Cytochrome c [Energy production and conversion]; Region: COG3258
688245010598 Cytochrome c; Region: Cytochrom_C; cl11414
688245010599 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
688245010600 ligand binding site; other site
688245010601 biotin biosynthesis protein BioC; Region: BioC; TIGR02072
688245010602 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245010603 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
688245010604 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
688245010605 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
688245010606 putative active site; other site
688245010607 putative catalytic site; other site
688245010608 LysE type translocator; Region: LysE; cl00565
688245010609 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
688245010610 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
688245010611 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245010612 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
688245010613 Cytochrome c; Region: Cytochrom_C; cl11414
688245010614 Cytochrome c; Region: Cytochrom_C; cl11414
688245010615 ATPases associated with a variety of cellular activities; Region: AAA; smart00382
688245010616 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245010617 Walker A motif; other site
688245010618 ATP binding site; other site
688245010619 Walker B motif; other site
688245010620 arginine finger; other site
688245010621 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
688245010622 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
688245010623 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
688245010624 Surface antigen; Region: Bac_surface_Ag; cl03097
688245010625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
688245010626 Family of unknown function (DUF490); Region: DUF490; pfam04357
688245010627 Uncharacterized BCR, COG1937; Region: DUF156; cl00846
688245010628 Cation efflux family; Region: Cation_efflux; cl00316
688245010629 Domain of unknown function (DU1801); Region: DUF1801; cl01838
688245010630 Chromate transporter; Region: Chromate_transp; cl00902
688245010631 Chromate transporter; Region: Chromate_transp; cl00902
688245010632 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245010633 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
688245010634 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415
688245010635 putative dimerization interface; other site
688245010636 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604
688245010637 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
688245010638 putative active site; other site
688245010639 heme pocket; other site
688245010640 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245010641 metal-binding site
688245010642 active site
688245010643 I-site; other site
688245010644 cAMP phosphodiesterase; Provisional; Region: PRK11359
688245010645 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245010646 metal-binding site
688245010647 active site
688245010648 I-site; other site
688245010649 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
688245010650 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080
688245010651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245010652 Mg2+ binding site; other site
688245010653 G-X-G motif; other site
688245010654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245010655 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
688245010656 active site
688245010657 phosphorylation site
688245010658 intermolecular recognition site; other site
688245010659 dimerization interface; other site
688245010660 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
688245010661 DNA binding site
688245010662 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
688245010663 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245010664 Walker A/P-loop; other site
688245010665 ATP binding site; other site
688245010666 Q-loop/lid; other site
688245010667 ABC transporter signature motif; other site
688245010668 Walker B; other site
688245010669 D-loop; other site
688245010670 H-loop/switch region; other site
688245010671 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053
688245010672 active site
688245010673 catalytic residues; other site
688245010674 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
688245010675 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149
688245010676 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
688245010677 protein binding site; other site
688245010678 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
688245010679 catalytic residues; other site
688245010680 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245010681 Permease family; Region: Xan_ur_permease; cl00967
688245010682 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
688245010683 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
688245010684 active site
688245010685 putative substrate binding pocket; other site
688245010686 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245010687 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245010688 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245010689 dimerization interface; other site
688245010690 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
688245010691 putative acyl-acceptor binding pocket; other site
688245010692 dihydroorotase; Provisional; Region: PRK07627
688245010693 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
688245010694 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317
688245010695 active site
688245010696 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
688245010697 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
688245010698 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
688245010699 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
688245010700 Uncharacterized protein family (UPF0081); Region: UPF0081; cl00525
688245010701 Uncharacterized ACR, COG1678; Region: DUF179; cl00731
688245010702 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
688245010703 DNA photolyase; Region: DNA_photolyase; pfam00875
688245010704 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
688245010705 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
688245010706 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
688245010707 putative binding surface; other site
688245010708 active site
688245010709 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
688245010710 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
688245010711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245010712 ATP binding site; other site
688245010713 Mg2+ binding site; other site
688245010714 G-X-G motif; other site
688245010715 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
688245010716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245010717 active site
688245010718 phosphorylation site
688245010719 intermolecular recognition site; other site
688245010720 dimerization interface; other site
688245010721 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
688245010722 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144
688245010723 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
688245010724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245010725 active site
688245010726 phosphorylation site
688245010727 intermolecular recognition site; other site
688245010728 dimerization interface; other site
688245010729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245010730 active site
688245010731 phosphorylation site
688245010732 intermolecular recognition site; other site
688245010733 dimerization interface; other site
688245010734 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730
688245010735 iron binding site; other site
688245010736 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192
688245010737 substrate binding site; other site
688245010738 ATP binding site; other site
688245010739 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
688245010740 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
688245010741 inhibitor-cofactor binding pocket; inhibition site
688245010742 pyridoxal 5'-phosphate binding site; other site
688245010743 catalytic residue; other site
688245010744 PhoD-like phosphatase; Region: PhoD; pfam09423
688245010745 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
688245010746 putative active site; other site
688245010747 putative metal binding site; other site
688245010748 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
688245010749 Methyladenine glycosylase; Region: Adenine_glyco; cl01059
688245010750 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
688245010751 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
688245010752 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
688245010753 active site
688245010754 Cytochrome c; Region: Cytochrom_C; cl11414
688245010755 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
688245010756 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421
688245010757 purine monophosphate binding site; other site
688245010758 dimer interface; other site
688245010759 putative catalytic residues; other site
688245010760 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
688245010761 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
688245010762 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
688245010763 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
688245010764 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801
688245010765 FMN binding site; other site
688245010766 active site
688245010767 catalytic residues; other site
688245010768 substrate binding site; other site
688245010769 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813
688245010770 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
688245010771 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
688245010772 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659
688245010773 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
688245010774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245010775 active site
688245010776 phosphorylation site
688245010777 intermolecular recognition site; other site
688245010778 dimerization interface; other site
688245010779 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
688245010780 DNA binding residues
688245010781 dimerization interface; other site
688245010782 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080
688245010783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245010784 ATP binding site; other site
688245010785 Mg2+ binding site; other site
688245010786 G-X-G motif; other site
688245010787 Outer membrane efflux protein; Region: OEP; pfam02321
688245010788 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
688245010789 Outer membrane efflux protein; Region: OEP; pfam02321
688245010790 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
688245010791 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
688245010792 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245010793 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106
688245010794 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572
688245010795 dimerization interface; other site
688245010796 active site
688245010797 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447
688245010798 PAS fold; Region: PAS_4; pfam08448
688245010799 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
688245010800 putative active site; other site
688245010801 heme pocket; other site
688245010802 PAS domain S-box; Region: sensory_box; TIGR00229
688245010803 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
688245010804 putative active site; other site
688245010805 heme pocket; other site
688245010806 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245010807 metal-binding site
688245010808 active site
688245010809 I-site; other site
688245010810 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937
688245010811 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
688245010812 dinuclear metal binding motif; other site
688245010813 RNA polymerase sigma factor; Provisional; Region: PRK12514
688245010814 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
688245010815 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055
688245010816 Anti-sigma-K factor rskA; Region: RskA; cl02208
688245010817 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
688245010818 Moco binding site; other site
688245010819 metal coordination site; other site
688245010820 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
688245010821 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
688245010822 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
688245010823 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
688245010824 putative heme binding pocket; other site
688245010825 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
688245010826 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a beta...; Region: Arsenite_oxidase; cd02135
688245010827 putative FMN binding site; other site
688245010828 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245010829 Integral membrane protein TerC family; Region: TerC; cl10468
688245010830 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
688245010831 Ligand Binding Site; other site
688245010832 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245010833 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
688245010834 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245010835 dimerization interface; other site
688245010836 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245010837 metal-binding site
688245010838 active site
688245010839 I-site; other site
688245010840 Protein of unknown function (DUF1428); Region: DUF1428; cl02319
688245010841 GTP-dependent nucleic acid-binding protein EngD; Reviewed; Region: PRK09601
688245010842 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900
688245010843 G1 box; other site
688245010844 GTP/Mg2+ binding site; other site
688245010845 Switch I region; other site
688245010846 G2 box; other site
688245010847 Switch II region; other site
688245010848 G3 box; other site
688245010849 G4 box; other site
688245010850 G5 box; other site
688245010851 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
688245010852 insertion element IS2 transposase InsD; Reviewed; Region: PRK09409
688245010853 Integrase core domain; Region: rve; cl01316
688245010854 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
688245010855 C-terminal domain; Region: primase_Cterm; TIGR01613
688245010856 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323
688245010857 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358
688245010858 Restriction endonuclease; Region: Mrr_cat; cl00747
688245010859 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
688245010860 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
688245010861 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
688245010862 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408
688245010863 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
688245010864 ATP binding site; other site
688245010865 putative Mg++ binding site; other site
688245010866 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
688245010867 nucleotide binding region; other site
688245010868 ATP-binding site; other site
688245010869 Predicted transcriptional regulator [Transcription]; Region: COG2378
688245010870 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
688245010871 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
688245010872 MOSC domain; Region: MOSC; pfam03473
688245010873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245010874 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
688245010875 thiol:disulfide interchange protein DsbC; Provisional; Region: PRK10877
688245010876 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide...; Region: DsbA_DsbC_DsbG; cd03020
688245010877 dimerization domain; other site
688245010878 dimer interface; other site
688245010879 catalytic residues; other site
688245010880 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
688245010881 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
688245010882 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
688245010883 enoyl-CoA hydratase; Provisional; Region: PRK05980
688245010884 substrate binding site; other site
688245010885 oxyanion hole (OAH) forming residues; other site
688245010886 trimer interface; other site
688245010887 potential protein location (hypothetical protein CtCNB1_4057 [Comamonas testosteroni CNB-2]) that overlaps RNA (tRNA-M)
688245010888 benzoate transport; Region: 2A0115; TIGR00895
688245010889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245010890 putative substrate translocation pore; other site
688245010891 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245010892 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245010893 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
688245010894 substrate binding pocket; other site
688245010895 dimerization interface; other site
688245010896 benzoylformate decarboxylase; Reviewed; Region: PRK07092
688245010897 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
688245010898 PYR/PP interface; other site
688245010899 dimer interface; other site
688245010900 TPP binding site; other site
688245010901 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
688245010902 TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of benzoylformate to benzaldehyde and carbon dioxide. This...; Region: TPP_BFDC; cd02002
688245010903 TPP-binding site; other site
688245010904 dimer interface; other site
688245010905 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
688245010906 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245010907 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
688245010908 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245010909 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245010910 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245010911 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245010912 TOBE domain; Region: TOBE_2; cl01440
688245010913 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245010914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245010915 dimer interface; other site
688245010916 conserved gate region; other site
688245010917 putative PBP binding loops; other site
688245010918 ABC-ATPase subunit interface; other site
688245010919 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
688245010920 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245010921 Walker A/P-loop; other site
688245010922 ATP binding site; other site
688245010923 Q-loop/lid; other site
688245010924 ABC transporter signature motif; other site
688245010925 Walker B; other site
688245010926 D-loop; other site
688245010927 H-loop/switch region; other site
688245010928 TOBE domain; Region: TOBE_2; cl01440
688245010929 FdhD/NarQ family; Region: FdhD-NarQ; cl00659
688245010930 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
688245010931 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
688245010932 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
688245010933 FeS/SAM binding site; other site
688245010934 TRAM domain; Region: TRAM; cl01282
688245010935 NlpC/P60 family; Region: NLPC_P60; cl11438
688245010936 signal recognition particle protein; Provisional; Region: PRK10867
688245010937 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
688245010938 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
688245010939 GTP binding site; other site
688245010940 Signal peptide binding domain; Region: SRP_SPB; pfam02978
688245010941 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
688245010942 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
688245010943 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans...; Region: HisKA; cd00082
688245010944 dimer interface; other site
688245010945 phosphorylation site
688245010946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245010947 ATP binding site; other site
688245010948 Mg2+ binding site; other site
688245010949 G-X-G motif; other site
688245010950 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
688245010951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245010952 active site
688245010953 phosphorylation site
688245010954 intermolecular recognition site; other site
688245010955 dimerization interface; other site
688245010956 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245010957 Walker A motif; other site
688245010958 ATP binding site; other site
688245010959 Walker B motif; other site
688245010960 arginine finger; other site
688245010961 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
688245010962 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
688245010963 amidase catalytic site; other site
688245010964 Zn binding residues; other site
688245010965 substrate binding site; other site
688245010966 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
688245010967 ATP cone domain; Region: ATP-cone; pfam03477
688245010968 Class I ribonucleotide reductase; Region: RNR_I; cd01679
688245010969 active site
688245010970 dimer interface; other site
688245010971 catalytic residues; other site
688245010972 effector binding site; other site
688245010973 R2 peptide binding site; other site
688245010974 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
688245010975 dimer interface; other site
688245010976 putative radical transfer pathway; other site
688245010977 diiron center; other site
688245010978 tyrosyl radical; other site
688245010979 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
688245010980 substrate binding site; other site
688245010981 ATP binding site; other site
688245010982 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
688245010983 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
688245010984 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
688245010985 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
688245010986 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
688245010987 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
688245010988 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
688245010989 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850
688245010990 carboxyltransferase (CT) interaction site; other site
688245010991 biotinylation site; other site
688245010992 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966
688245010993 catalytic residues; other site
688245010994 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
688245010995 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
688245010996 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
688245010997 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
688245010998 Domain of unknown function, DUF446; Region: DUF446; cl01187
688245010999 NeuB family; Region: NeuB; cl00496
688245011000 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
688245011001 Putative modulator of DNA gyrase; Region: PmbA_TldD; cl00398
688245011002 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
688245011003 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245011004 Exoribonuclease R [Transcription]; Region: VacB; COG0557
688245011005 RNB domain; Region: RNB; pfam00773
688245011006 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
688245011007 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
688245011008 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
688245011009 shikimate binding site; other site
688245011010 NAD(P) binding site; other site
688245011011 Transglycosylase; Region: Transgly; cl07896
688245011012 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529
688245011013 active site
688245011014 putative DNA-binding cleft; other site
688245011015 dimer interface; other site
688245011016 Domain of unknown function (DUF3315); Region: DUF3315; cl02275
688245011017 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512
688245011018 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
688245011019 cell division protein FtsZ; Validated; Region: PRK09330
688245011020 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201
688245011021 nucleotide binding site; other site
688245011022 SulA interaction site; other site
688245011023 cell division protein FtsA; Region: ftsA; TIGR01174
688245011024 Cell division protein FtsA; Region: FtsA; cl11496
688245011025 Cell division protein FtsA; Region: FtsA; cl11496
688245011026 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
688245011027 Cell division protein FtsQ; Region: FtsQ; pfam03799
688245011028 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
688245011029 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
688245011030 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
688245011031 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
688245011032 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
688245011033 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
688245011034 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
688245011035 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
688245011036 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785
688245011037 active site
688245011038 homodimer interface; other site
688245011039 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
688245011040 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006
688245011041 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
688245011042 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
688245011043 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
688245011044 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852
688245011045 Mg++ binding site; other site
688245011046 putative catalytic motif; other site
688245011047 putative substrate binding site; other site
688245011048 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
688245011049 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
688245011050 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
688245011051 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
688245011052 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
688245011053 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
688245011054 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
688245011055 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
688245011056 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
688245011057 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
688245011058 Septum formation initiator; Region: DivIC; cl11433
688245011059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245011060 MraZ protein; Region: MraZ; pfam02381
688245011061 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
688245011062 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245011063 Walker A motif; other site
688245011064 ATP binding site; other site
688245011065 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245011066 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
688245011067 active site
688245011068 HslU subunit interaction site; other site
688245011069 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
688245011070 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
688245011071 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
688245011072 P-loop, Walker A motif; other site
688245011073 Base recognition motif; other site
688245011074 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
688245011075 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
688245011076 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
688245011077 DNA binding site
688245011078 Int/Topo IB signature motif; other site
688245011079 active site
688245011080 potential frameshift: common BLAST hit: gi|222112166|ref|YP_002554430.1| protein of unknown function DUF484
688245011081 Protein of unknown function, DUF484; Region: DUF484; cl01228
688245011082 Protein of unknown function, DUF484; Region: DUF484; cl01228
688245011083 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
688245011084 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
688245011085 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
688245011086 Transcriptional regulators [Transcription]; Region: MarR; COG1846
688245011087 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245011088 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245011089 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341
688245011090 active site
688245011091 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245011092 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
688245011093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245011094 feruloyl-CoA synthase; Reviewed; Region: PRK08180
688245011095 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245011096 enoyl-CoA hydratase; Provisional; Region: PRK06142
688245011097 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
688245011098 substrate binding site; other site
688245011099 oxyanion hole (OAH) forming residues; other site
688245011100 trimer interface; other site
688245011101 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cl11392
688245011102 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447
688245011103 nudix motif; other site
688245011104 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
688245011105 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
688245011106 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
688245011107 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130
688245011108 active site
688245011109 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
688245011110 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
688245011111 FAD binding pocket; other site
688245011112 FAD binding motif; other site
688245011113 phosphate binding motif; other site
688245011114 NAD binding pocket; other site
688245011115 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718
688245011116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
688245011117 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
688245011118 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245011119 N-terminal plug; other site
688245011120 ligand-binding site; other site
688245011121 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
688245011122 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
688245011123 Cupin domain; Region: Cupin_2; cl09118
688245011124 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
688245011125 EamA-like transporter family; Region: EamA; cl01037
688245011126 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
688245011127 EamA-like transporter family; Region: EamA; cl01037
688245011128 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
688245011129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245011130 putative substrate translocation pore; other site
688245011131 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010
688245011132 amidase; Provisional; Region: PRK07056
688245011133 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
688245011134 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245011135 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245011136 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
688245011137 dimerization interface; other site
688245011138 cysteine synthases; Region: cysKM; TIGR01136
688245011139 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561
688245011140 dimer interface; other site
688245011141 pyridoxal 5'-phosphate binding site; other site
688245011142 catalytic residue; other site
688245011143 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
688245011144 ABC transporter transmembrane region; Region: ABC_membrane; cl00549
688245011145 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245011146 Walker A/P-loop; other site
688245011147 ATP binding site; other site
688245011148 Q-loop/lid; other site
688245011149 ABC transporter signature motif; other site
688245011150 Walker B; other site
688245011151 D-loop; other site
688245011152 H-loop/switch region; other site
688245011153 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
688245011154 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
688245011155 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457
688245011156 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245011157 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245011158 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
688245011159 putative effector binding pocket; other site
688245011160 dimerization interface; other site
688245011161 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
688245011162 Quinone oxidoreductase (QOR); Region: QOR2; cd05286
688245011163 NADP binding site; other site
688245011164 dimer interface; other site
688245011165 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278
688245011166 exonuclease subunit SbcD; Provisional; Region: PRK10966
688245011167 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
688245011168 active site
688245011169 metal-binding site
688245011170 DNA binding site
688245011171 Type 5 capsule protein repressor C terminal; Region: SbcD_C; pfam12320
688245011172 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245011173 Walker A/P-loop; other site
688245011174 ATP binding site; other site
688245011175 Q-loop/lid; other site
688245011176 exonuclease subunit SbcC; Provisional; Region: PRK10246
688245011177 exonuclease subunit SbcC; Provisional; Region: PRK10246
688245011178 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245011179 ABC transporter signature motif; other site
688245011180 Walker B; other site
688245011181 D-loop; other site
688245011182 H-loop/switch region; other site
688245011183 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457
688245011184 putative active site; other site
688245011185 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710
688245011186 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
688245011187 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688245011188 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688245011189 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
688245011190 enoyl-CoA hydratase; Provisional; Region: PRK05980
688245011191 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
688245011192 substrate binding site; other site
688245011193 oxyanion hole (OAH) forming residues; other site
688245011194 trimer interface; other site
688245011195 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cl11392
688245011196 Peptidase family M48; Region: Peptidase_M48; cl12018
688245011197 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227
688245011198 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167
688245011199 putative metal binding site; other site
688245011200 Dihydroorotase [Nucleotide transport and metabolism]; Region: PyrC; COG0418
688245011201 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
688245011202 active site
688245011203 substrate binding pocket; other site
688245011204 dimer interface; other site
688245011205 ornithine cyclodeaminase; Validated; Region: PRK07589
688245011206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245011207 Arginase family; Region: Arginase; cl00306
688245011208 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
688245011209 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
688245011210 Walker A/P-loop; other site
688245011211 ATP binding site; other site
688245011212 Q-loop/lid; other site
688245011213 ABC transporter signature motif; other site
688245011214 Walker B; other site
688245011215 D-loop; other site
688245011216 H-loop/switch region; other site
688245011217 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
688245011218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245011219 dimer interface; other site
688245011220 conserved gate region; other site
688245011221 putative PBP binding loops; other site
688245011222 ABC-ATPase subunit interface; other site
688245011223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245011224 dimer interface; other site
688245011225 conserved gate region; other site
688245011226 putative PBP binding loops; other site
688245011227 ABC-ATPase subunit interface; other site
688245011228 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
688245011229 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
688245011230 substrate binding pocket; other site
688245011231 membrane-bound complex binding site; other site
688245011232 hinge residues; other site
688245011233 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245011234 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245011235 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
688245011236 dimerization interface; other site
688245011237 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
688245011238 DctM-like transporters; Region: DctM; pfam06808
688245011239 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688245011240 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710
688245011241 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
688245011242 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245011243 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
688245011244 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron...; Region: PDR_like; cd06185
688245011245 FMN-binding pocket; other site
688245011246 flavin binding motif; other site
688245011247 phosphate binding motif; other site
688245011248 beta-alpha-beta structure motif; other site
688245011249 NAD binding pocket; other site
688245011250 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
688245011251 catalytic loop; other site
688245011252 iron binding site; other site
688245011253 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
688245011254 N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to tolerate and utilize aromatic compounds for growth. The oxygenase alpha subunit contains an N...; Region: Rieske_RO_Alpha_VanA_DdmC; cd03532
688245011255 benzoate transport; Region: 2A0115; TIGR00895
688245011256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245011257 putative substrate translocation pore; other site
688245011258 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245011259 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938
688245011260 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
688245011261 iron-sulfur cluster; other site
688245011262 [2Fe-2S] cluster binding site; other site
688245011263 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
688245011264 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245011265 DNA binding site
688245011266 FCD domain; Region: FCD; cl11656
688245011267 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
688245011268 ABC transporter transmembrane region; Region: ABC_membrane; cl00549
688245011269 ATM1 is an ABC transporter that is expressed in the mitochondria. Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to...; Region: ABCC_ATM1_transporter; cd03253
688245011270 Walker A/P-loop; other site
688245011271 ATP binding site; other site
688245011272 Q-loop/lid; other site
688245011273 ABC transporter signature motif; other site
688245011274 Walker B; other site
688245011275 D-loop; other site
688245011276 H-loop/switch region; other site
688245011277 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442
688245011278 Protein of unknown function, DUF583; Region: DUF583; cl09137
688245011279 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
688245011280 CoenzymeA binding site; other site
688245011281 subunit interaction site; other site
688245011282 PHB binding site; other site
688245011283 enoyl-CoA hydratase; Provisional; Region: PRK05980
688245011284 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
688245011285 substrate binding site; other site
688245011286 oxyanion hole (OAH) forming residues; other site
688245011287 trimer interface; other site
688245011288 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
688245011289 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245011290 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245011291 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
688245011292 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
688245011293 dimer interface; other site
688245011294 active site
688245011295 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
688245011296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245011297 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
688245011298 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
688245011299 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
688245011300 substrate binding site; other site
688245011301 oxyanion hole (OAH) forming residues; other site
688245011302 trimer interface; other site
688245011303 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951
688245011304 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
688245011305 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
688245011306 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245011307 active site
688245011308 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
688245011309 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
688245011310 nucleoid occlusion protein; Provisional; Region: slmA; PRK09480
688245011311 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
688245011312 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
688245011313 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
688245011314 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
688245011315 dimer interface; other site
688245011316 phosphorylation site
688245011317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245011318 ATP binding site; other site
688245011319 Mg2+ binding site; other site
688245011320 G-X-G motif; other site
688245011321 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
688245011322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245011323 active site
688245011324 phosphorylation site
688245011325 intermolecular recognition site; other site
688245011326 dimerization interface; other site
688245011327 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
688245011328 DNA binding site
688245011329 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250
688245011330 feedback inhibition sensing region; other site
688245011331 homohexameric interface; other site
688245011332 nucleotide binding site; other site
688245011333 N-acetyl-L-glutamate binding site; other site
688245011334 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases...; Region: GT_MraY_like; cd06912
688245011335 Mg++ binding site; other site
688245011336 putative catalytic motif; other site
688245011337 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
688245011338 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
688245011339 putative ADP-binding pocket; other site
688245011340 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513
688245011341 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
688245011342 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
688245011343 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
688245011344 active site
688245011345 homodimer interface; other site
688245011346 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
688245011347 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092
688245011348 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
688245011349 glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388
688245011350 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
688245011351 dimer interface; other site
688245011352 motif 1; other site
688245011353 active site
688245011354 motif 2; other site
688245011355 motif 3; other site
688245011356 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408
688245011357 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
688245011358 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
688245011359 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271
688245011360 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed
688245011361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245011362 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
688245011363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245011364 dimer interface; other site
688245011365 conserved gate region; other site
688245011366 putative PBP binding loops; other site
688245011367 ABC-ATPase subunit interface; other site
688245011368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245011369 dimer interface; other site
688245011370 conserved gate region; other site
688245011371 putative PBP binding loops; other site
688245011372 ABC-ATPase subunit interface; other site
688245011373 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
688245011374 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245011375 Walker A/P-loop; other site
688245011376 ATP binding site; other site
688245011377 Q-loop/lid; other site
688245011378 ABC transporter signature motif; other site
688245011379 Walker B; other site
688245011380 D-loop; other site
688245011381 H-loop/switch region; other site
688245011382 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
688245011383 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245011384 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
688245011385 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245011386 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
688245011387 dimerization interface; other site
688245011388 Cupin domain; Region: Cupin_2; cl09118
688245011389 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
688245011390 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
688245011391 substrate binding site; other site
688245011392 tetramer interface; other site
688245011393 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987
688245011394 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987
688245011395 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
688245011396 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245011397 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130
688245011398 LysM domain/BON superfamily protein; Provisional; Region: PRK11198
688245011399 Putative phospholipid-binding domain; Region: BON; cl02771
688245011400 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
688245011401 putative peptidoglycan binding site; other site
688245011402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245011403 UDP-glucose 4-epimerase; Region: PLN02240
688245011404 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
688245011405 active site residue
688245011406 Protein of unknown function DUF45; Region: DUF45; cl00636
688245011407 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
688245011408 putative acyl-acceptor binding pocket; other site
688245011409 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
688245011410 active site
688245011411 motif I; other site
688245011412 motif II; other site
688245011413 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
688245011414 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
688245011415 dimer interface; other site
688245011416 active site
688245011417 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
688245011418 dimer interface; other site
688245011419 active site 1
688245011420 active site 2
688245011421 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
688245011422 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
688245011423 putative active site; other site
688245011424 catalytic triad; other site
688245011425 putative dimer interface; other site
688245011426 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
688245011427 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
688245011428 Transporter associated domain; Region: CorC_HlyC; pfam03471
688245011429 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00443
688245011430 Transcriptional regulators [Transcription]; Region: Lrp; COG1522
688245011431 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245011432 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
688245011433 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
688245011434 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245011435 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH)...; Region: pro_PheOH; cd03348
688245011436 cofactor binding site; other site
688245011437 metal-binding site
688245011438 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
688245011439 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
688245011440 Mechanosensitive ion channel; Region: MS_channel; pfam00924
688245011441 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
688245011442 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245011443 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl11605
688245011444 hemerythrin-like metal-binding domain; Region: hemeryth_dom; TIGR02481
688245011445 octamerization interface; other site
688245011446 diferric-oxygen binding site; other site
688245011447 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
688245011448 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
688245011449 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
688245011450 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
688245011451 FAD binding pocket; other site
688245011452 FAD binding motif; other site
688245011453 phosphate binding motif; other site
688245011454 NAD binding pocket; other site
688245011455 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245011456 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840
688245011457 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245011458 N-terminal plug; other site
688245011459 ligand-binding site; other site
688245011460 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206
688245011461 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486
688245011462 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245011463 N-terminal plug; other site
688245011464 ligand-binding site; other site
688245011465 lytic murein transglycosylase; Provisional; Region: PRK11619
688245011466 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254
688245011467 N-acetyl-D-glucosamine binding site; other site
688245011468 catalytic residue; other site
688245011469 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
688245011470 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
688245011471 Ligand Binding Site; other site
688245011472 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
688245011473 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH)...; Region: GST_N_1; cd03043
688245011474 putative C-terminal domain interface; other site
688245011475 putative GSH binding site (G-site); other site
688245011476 putative dimer interface; other site
688245011477 GST_C family, unknown subfamily 3; composed of uncharacterized proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous...; Region: GST_C_3; cd03194
688245011478 putative N-terminal domain interface; other site
688245011479 putative dimer interface; other site
688245011480 putative substrate binding pocket (H-site); other site
688245011481 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
688245011482 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
688245011483 active site
688245011484 NTP binding site; other site
688245011485 metal binding triad; metal-binding site
688245011486 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
688245011487 Zn2+ binding site; other site
688245011488 Mg2+ binding site; other site
688245011489 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
688245011490 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
688245011491 NAD binding site; other site
688245011492 substrate binding site; other site
688245011493 catalytic Zn binding site; other site
688245011494 tetramer interface; other site
688245011495 structural Zn binding site; other site
688245011496 thioredoxin 2; Provisional; Region: PRK10996
688245011497 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
688245011498 catalytic residues; other site
688245011499 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
688245011500 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245011501 Uncharacterized conserved protein [Function unknown]; Region: COG1565
688245011502 Uncharacterized ACR, COG1565; Region: DUF185; pfam02636
688245011503 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245011504 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
688245011505 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263
688245011506 active site
688245011507 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This...; Region: Alpha_ANH_like_II; cd01993
688245011508 Ligand Binding Site; other site
688245011509 Protein of unknown function (DUF2501); Region: DUF2501; cl08197
688245011510 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
688245011511 catalytic core; other site
688245011512 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
688245011513 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819
688245011514 dimer interface; other site
688245011515 active site
688245011516 pyridoxal 5'-phosphate (PLP) binding site; other site
688245011517 substrate binding site; other site
688245011518 catalytic residue; other site
688245011519 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
688245011520 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
688245011521 Peptidase dimerization domain; Region: M20_dimer; cl09126
688245011522 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245011523 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
688245011524 YhhN-like protein; Region: YhhN; cl01505
688245011525 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
688245011526 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
688245011527 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
688245011528 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
688245011529 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
688245011530 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
688245011531 MgtC family; Region: MgtC; pfam02308
688245011532 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
688245011533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245011534 Walker A motif; other site
688245011535 ATP binding site; other site
688245011536 Walker B motif; other site
688245011537 arginine finger; other site
688245011538 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
688245011539 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017
688245011540 catalytic triad; other site
688245011541 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
688245011542 RuvA N terminal domain; Region: RuvA_N; pfam01330
688245011543 RuvA, C-terminal domain; Region: RuvA_C; pfam07499
688245011544 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
688245011545 PhoH-like protein; Region: PhoH; cl12134
688245011546 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
688245011547 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
688245011548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245011549 ATP binding site; other site
688245011550 Mg2+ binding site; other site
688245011551 G-X-G motif; other site
688245011552 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
688245011553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245011554 active site
688245011555 phosphorylation site
688245011556 intermolecular recognition site; other site
688245011557 dimerization interface; other site
688245011558 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
688245011559 DNA binding residues
688245011560 dimerization interface; other site
688245011561 Domain of unknown function (DUF336); Region: DUF336; cl01249
688245011562 Surface antigen; Region: Surface_Ag_2; cl01155
688245011563 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245011564 Sulfite exporter TauE/SafE; Region: TauE; cl00498
688245011565 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
688245011566 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268
688245011567 ATP binding site; other site
688245011568 Mg++ binding site; other site
688245011569 motif III; other site
688245011570 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
688245011571 nucleotide binding region; other site
688245011572 ATP-binding site; other site
688245011573 DbpA RNA binding domain; Region: DbpA; pfam03880
688245011574 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
688245011575 Peptidase dimerization domain; Region: M20_dimer; cl09126
688245011576 Peptidase dimerization domain; Region: M20_dimer; cl09126
688245011577 dipeptidase PepV; Reviewed; Region: PRK07318
688245011578 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563
688245011579 putative active site; other site
688245011580 dimerization interface; other site
688245011581 putative tRNAtyr binding site; other site
688245011582 Cation efflux family; Region: Cation_efflux; cl00316
688245011583 PAS fold; Region: PAS_4; pfam08448
688245011584 PAS domain S-box; Region: sensory_box; TIGR00229
688245011585 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
688245011586 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245011587 metal-binding site
688245011588 active site
688245011589 I-site; other site
688245011590 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
688245011591 AMP nucleosidase; Provisional; Region: PRK08292
688245011592 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
688245011593 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
688245011594 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245011595 metal-binding site
688245011596 active site
688245011597 I-site; other site
688245011598 choline dehydrogenase; Validated; Region: PRK02106
688245011599 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
688245011600 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
688245011601 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
688245011602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245011603 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
688245011604 enoyl-CoA hydratase; Provisional; Region: PRK05980
688245011605 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
688245011606 substrate binding site; other site
688245011607 oxyanion hole (OAH) forming residues; other site
688245011608 trimer interface; other site
688245011609 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cl11392
688245011610 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
688245011611 Beta-lactamase; Region: Beta-lactamase; cl01009
688245011612 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245011613 OsmC-like protein; Region: OsmC; cl00767
688245011614 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
688245011615 Protein Kinases, catalytic domain; Region: PKc_like; cl09925
688245011616 Phosphotransferase enzyme family; Region: APH; pfam01636
688245011617 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
688245011618 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
688245011619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245011620 Major Facilitator Superfamily; Region: MFS_1; pfam07690
688245011621 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
688245011622 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
688245011623 DNA binding residues
688245011624 dimer interface; other site
688245011625 [2Fe-2S] cluster binding site; other site
688245011626 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
688245011627 homotrimer interaction site; other site
688245011628 putative active site; other site
688245011629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245011630 heat shock protein 90; Provisional; Region: PRK05218
688245011631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
688245011632 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
688245011633 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
688245011634 RNA binding surface; other site
688245011635 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130
688245011636 active site
688245011637 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
688245011638 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
688245011639 ligand binding site; other site
688245011640 flexible hinge region; other site
688245011641 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245011642 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
688245011643 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245011644 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245011645 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
688245011646 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219
688245011647 Walker A/P-loop; other site
688245011648 ATP binding site; other site
688245011649 Q-loop/lid; other site
688245011650 ABC transporter signature motif; other site
688245011651 Walker B; other site
688245011652 D-loop; other site
688245011653 H-loop/switch region; other site
688245011654 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
688245011655 TM-ABC transporter signature motif; other site
688245011656 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
688245011657 TM-ABC transporter signature motif; other site
688245011658 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
688245011659 putative ligand binding site; other site
688245011660 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
688245011661 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
688245011662 Walker A/P-loop; other site
688245011663 ATP binding site; other site
688245011664 Q-loop/lid; other site
688245011665 ABC transporter signature motif; other site
688245011666 Walker B; other site
688245011667 D-loop; other site
688245011668 H-loop/switch region; other site
688245011669 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245011670 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245011671 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895
688245011672 Cyclopropane-fatty-acyl-phospholipid synthase; Region: CMAS; pfam02353
688245011673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
688245011674 S-adenosylmethionine binding site; other site
688245011675 Protein Kinases, catalytic domain; Region: PKc_like; cl09925
688245011676 Predicted aminopeptidase (DUF2265); Region: DUF2265; cl01778
688245011677 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
688245011678 Sulfatase; Region: Sulfatase; cl10460
688245011679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245011680 dimer interface; other site
688245011681 conserved gate region; other site
688245011682 putative PBP binding loops; other site
688245011683 ABC-ATPase subunit interface; other site
688245011684 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
688245011685 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293
688245011686 Walker A/P-loop; other site
688245011687 ATP binding site; other site
688245011688 Q-loop/lid; other site
688245011689 ABC transporter signature motif; other site
688245011690 Walker B; other site
688245011691 D-loop; other site
688245011692 H-loop/switch region; other site
688245011693 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245011694 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
688245011695 nucleoside/Zn binding site; other site
688245011696 dimer interface; other site
688245011697 catalytic motif; other site
688245011698 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
688245011699 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245011700 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
688245011701 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206
688245011702 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221
688245011703 acyl-CoA binding pocket; other site
688245011704 CoA binding site; other site
688245011705 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342
688245011706 trimer interface; other site
688245011707 eyelet of channel; other site
688245011708 Quinone oxidoreductase (QOR); Region: QOR2; cd05286
688245011709 NADP binding site; other site
688245011710 dimer interface; other site
688245011711 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245011712 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl01276
688245011713 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184
688245011714 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
688245011715 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
688245011716 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
688245011717 Peptidase dimerization domain; Region: M20_dimer; cl09126
688245011718 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
688245011719 putative ligand binding site; other site
688245011720 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These...; Region: MopB_3; cd02766
688245011721 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
688245011722 putative [4Fe-4S] binding site; other site
688245011723 putative molybdopterin cofactor binding site; other site
688245011724 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-; Region: MopB_CT; cl09929
688245011725 molybdopterin cofactor binding site; other site
688245011726 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
688245011727 Cache domain; Region: Cache_1; pfam02743
688245011728 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245011729 metal-binding site
688245011730 active site
688245011731 I-site; other site
688245011732 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
688245011733 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245011734 Cytochrome c; Region: Cytochrom_C; cl11414
688245011735 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151
688245011736 homotrimer interaction site; other site
688245011737 putative active site; other site
688245011738 Bacterial protein of unknown function (DUF894); Region: DUF894; pfam05977
688245011739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245011740 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
688245011741 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012
688245011742 Isochorismatase family; Region: Isochorismatase; pfam00857
688245011743 catalytic triad; other site
688245011744 dimer interface; other site
688245011745 conserved cis-peptide bond; other site
688245011746 Pirin-related protein [General function prediction only]; Region: COG1741
688245011747 Cupin domain; Region: Cupin_2; cl09118
688245011748 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
688245011749 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245011750 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245011751 dimerization interface; other site
688245011752 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245011753 GumN protein; Region: GumN; cl12050
688245011754 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
688245011755 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245011756 Transcriptional regulator [Transcription]; Region: IclR; COG1414
688245011757 Bacterial transcriptional regulator; Region: IclR; pfam01614
688245011758 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
688245011759 Protein of unknown function (DUF3567); Region: DUF3567; pfam12091
688245011760 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
688245011761 Putative ammonia monooxygenase; Region: AmoA; pfam05145
688245011762 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
688245011763 Protein of unknown function, DUF399; Region: DUF399; cl01139
688245011764 PAS domain S-box; Region: sensory_box; TIGR00229
688245011765 PAS fold; Region: PAS_3; pfam08447
688245011766 PAS domain S-box; Region: sensory_box; TIGR00229
688245011767 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
688245011768 putative active site; other site
688245011769 heme pocket; other site
688245011770 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688245011771 metal-binding site
688245011772 active site
688245011773 I-site; other site
688245011774 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
688245011775 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
688245011776 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
688245011777 Formyl transferase; Region: Formyl_trans_N; cl00395
688245011778 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
688245011779 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245011780 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
688245011781 dimerization interface; other site
688245011782 substrate binding pocket; other site
688245011783 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
688245011784 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
688245011785 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
688245011786 putative ligand binding site; other site
688245011787 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
688245011788 FAD binding domain; Region: FAD_binding_4; cl10516
688245011789 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
688245011790 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342
688245011791 pyridoxal 5'-phosphate binding pocket; other site
688245011792 catalytic residue; other site
688245011793 Pseudomonas-type; Region: PC_PLC; TIGR03396
688245011794 Phosphoesterase family; Region: Phosphoesterase; cl10627
688245011795 Domain of unknown function (DUF756); Region: DUF756; pfam05506
688245011796 Domain of unknown function (DUF756); Region: DUF756; pfam05506
688245011797 heavy metal efflux pump (cobalt-zinc-cadmium); Region: 2A0601; TIGR00914
688245011798 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
688245011799 Outer membrane efflux protein; Region: OEP; pfam02321
688245011800 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
688245011801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245011802 active site
688245011803 phosphorylation site
688245011804 intermolecular recognition site; other site
688245011805 dimerization interface; other site
688245011806 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
688245011807 DNA binding site
688245011808 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
688245011809 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
688245011810 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
688245011811 dimer interface; other site
688245011812 phosphorylation site
688245011813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245011814 ATP binding site; other site
688245011815 G-X-G motif; other site
688245011816 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
688245011817 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
688245011818 putative ligand binding residues; other site
688245011819 enterobactin receptor protein; Provisional; Region: PRK13483
688245011820 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245011821 N-terminal plug; other site
688245011822 ligand-binding site; other site
688245011823 Protein of unknown function (DUF445); Region: DUF445; pfam04286
688245011824 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
688245011825 Outer membrane efflux protein; Region: OEP; pfam02321
688245011826 Predicted glycosyltransferases [General function prediction only]; Region: COG1216
688245011827 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423
688245011828 DXD motif; other site
688245011829 DNA polymerase II large subunit; Provisional; Region: PRK14714
688245011830 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191
688245011831 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
688245011832 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
688245011833 nitric oxide dioxygenase; Provisional; Region: PRK13289
688245011834 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
688245011835 heme-binding site; other site
688245011836 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
688245011837 FAD binding pocket; other site
688245011838 FAD binding motif; other site
688245011839 phosphate binding motif; other site
688245011840 beta-alpha-beta structure motif; other site
688245011841 NAD binding pocket; other site
688245011842 Heme binding pocket; other site
688245011843 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
688245011844 GAF domain; Region: GAF; cl00853
688245011845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688245011846 Walker A motif; other site
688245011847 ATP binding site; other site
688245011848 Walker B motif; other site
688245011849 arginine finger; other site
688245011850 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
688245011851 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
688245011852 pyridoxal 5'-phosphate binding pocket; other site
688245011853 catalytic residue; other site
688245011854 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
688245011855 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
688245011856 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
688245011857 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
688245011858 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850
688245011859 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); Region: sucB; TIGR01347
688245011860 carboxyltransferase (CT) interaction site; other site
688245011861 biotinylation site; other site
688245011862 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
688245011863 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513
688245011864 acyl-CoA synthetase; Validated; Region: PRK06178
688245011865 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245011866 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
688245011867 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
688245011868 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
688245011869 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
688245011870 putative ligand binding site; other site
688245011871 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
688245011872 pyridoxal 5'-phosphate (PLP) binding site; other site
688245011873 catalytic residue; other site
688245011874 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
688245011875 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
688245011876 Walker A motif; other site
688245011877 ATP binding site; other site
688245011878 Walker B motif; other site
688245011879 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
688245011880 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688245011881 Walker A motif; other site
688245011882 ATP binding site; other site
688245011883 Walker B motif; other site
688245011884 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
688245011885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245011886 Putative phospholipid-binding domain; Region: BON; cl02771
688245011887 Putative phospholipid-binding domain; Region: BON; cl02771
688245011888 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
688245011889 dimer interface; other site
688245011890 active site
688245011891 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516
688245011892 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
688245011893 putative chaperone; Provisional; Region: PRK11678
688245011894 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
688245011895 OsmC-like protein; Region: OsmC; cl00767
688245011896 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
688245011897 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
688245011898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245011899 dimer interface; other site
688245011900 conserved gate region; other site
688245011901 putative PBP binding loops; other site
688245011902 ABC-ATPase subunit interface; other site
688245011903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
688245011904 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
688245011905 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
688245011906 Walker A/P-loop; other site
688245011907 ATP binding site; other site
688245011908 Q-loop/lid; other site
688245011909 ABC transporter signature motif; other site
688245011910 Walker B; other site
688245011911 D-loop; other site
688245011912 H-loop/switch region; other site
688245011913 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
688245011914 Walker A/P-loop; other site
688245011915 ATP binding site; other site
688245011916 Q-loop/lid; other site
688245011917 ABC transporter signature motif; other site
688245011918 Walker B; other site
688245011919 D-loop; other site
688245011920 H-loop/switch region; other site
688245011921 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
688245011922 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
688245011923 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
688245011924 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
688245011925 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
688245011926 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688245011927 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
688245011928 Ribosomal protein L17; Region: Ribosomal_L17; cl00356
688245011929 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
688245011930 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
688245011931 alphaNTD homodimer interface; other site
688245011932 alphaNTD - beta interaction site; other site
688245011933 alphaNTD - beta' interaction site; other site
688245011934 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
688245011935 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
688245011936 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
688245011937 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
688245011938 RNA binding surface; other site
688245011939 Ribosomal protein S11; Region: Ribosomal_S11; cl00332
688245011940 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
688245011941 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
688245011942 Ribosomal protein L36; Region: Ribosomal_L36; cl00380
688245011943 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
688245011944 eubacterial secY protein; Region: SecY; pfam00344
688245011945 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
688245011946 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658
688245011947 23S rRNA binding site; other site
688245011948 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
688245011949 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
688245011950 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
688245011951 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
688245011952 5S rRNA interface; other site
688245011953 23S rRNA interface; other site
688245011954 L5 interface; other site
688245011955 50S ribosomal protein L6; Validated; Region: rplF; PRK05498
688245011956 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
688245011957 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
688245011958 Ribosomal protein S8; Region: Ribosomal_S8; cl00330
688245011959 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
688245011960 50S ribosomal protein L5; Validated; Region: rplE; PRK00010
688245011961 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
688245011962 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
688245011963 KOW motif; Region: KOW; cl00354
688245011964 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
688245011965 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
688245011966 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
688245011967 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245011968 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
688245011969 Acetyltransferases [General function prediction only]; Region: RimI; COG0456
688245011970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
688245011971 Coenzyme A binding pocket; other site
688245011972 glycerol kinase; Provisional; Region: glpK; PRK00047
688245011973 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; pfam00370
688245011974 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782
688245011975 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cl00200
688245011976 amphipathic channel; other site
688245011977 Asn-Pro-Ala signature motifs; other site
688245011978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
688245011979 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
688245011980 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245011981 UbiA prenyltransferase family; Region: UbiA; cl00337
688245011982 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
688245011983 active site
688245011984 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
688245011985 dimerization interface; other site
688245011986 DPS ferroxidase diiron center; other site
688245011987 ion pore; other site
688245011988 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
688245011989 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245011990 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
688245011991 dimerization interface; other site
688245011992 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
688245011993 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488
688245011994 generic binding surface II; other site
688245011995 ssDNA binding site; other site
688245011996 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
688245011997 ATP binding site; other site
688245011998 putative Mg++ binding site; other site
688245011999 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
688245012000 nucleotide binding region; other site
688245012001 ATP-binding site; other site
688245012002 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
688245012003 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
688245012004 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
688245012005 Zn2+ binding site; other site
688245012006 Mg2+ binding site; other site
688245012007 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
688245012008 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
688245012009 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
688245012010 Uracil DNA glycosylase superfamily; Region: UDG; cl00483
688245012011 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
688245012012 DNA binding site
688245012013 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
688245012014 active site
688245012015 ribulose/triose binding site; other site
688245012016 phosphate binding site; other site
688245012017 substrate (anthranilate) binding pocket; other site
688245012018 product (indole) binding pocket; other site
688245012019 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
688245012020 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
688245012021 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
688245012022 para-aminobenzoate synthase component II; Provisional; Region: PRK08857
688245012023 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
688245012024 glutamine binding; other site
688245012025 catalytic triad; other site
688245012026 Chorismate mutase type II; Region: CM_2; cl00693
688245012027 anthranilate synthase component I; Provisional; Region: PRK13565
688245012028 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
688245012029 chorismate binding enzyme; Region: Chorismate_bind; cl10555
688245012030 Chalcone-flavanone isomerase; Region: Chalcone; cl03589
688245012031 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687
688245012032 spermidine synthase; Provisional; Region: PRK00811
688245012033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245012034 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
688245012035 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
688245012036 motif II; other site
688245012037 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429
688245012038 substrate binding site; other site
688245012039 hexamer interface; other site
688245012040 metal-binding site
688245012041 Protein of unknown function (DUF525); Region: DUF525; cl01119
688245012042 Site-specific recombinase [DNA replication, recombination, and repair]; Region: COG4389
688245012043 Site-specific recombinase; Region: SpecificRecomb; pfam10136
688245012044 thiamine monophosphate kinase; Provisional; Region: PRK05731
688245012045 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
688245012046 ATP binding site; other site
688245012047 dimerization interface; other site
688245012048 conserved hypothetical protein; Region: TIGR02231
688245012049 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
688245012050 tetramer interfaces; other site
688245012051 binuclear metal-binding site; other site
688245012052 Competence-damaged protein; Region: CinA; cl00666
688245012053 Predicted membrane protein [Function unknown]; Region: COG4655
688245012054 Predicted membrane protein (DUF2134); Region: DUF2134; pfam09977
688245012055 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266
688245012056 cellulose synthase subunit BcsC; Provisional; Region: PRK11447
688245012057 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
688245012058 binding surface
688245012059 TPR motif; other site
688245012060 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
688245012061 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
688245012062 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
688245012063 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130
688245012064 ATP binding site; other site
688245012065 Walker A motif; other site
688245012066 hexamer interface; other site
688245012067 Walker B motif; other site
688245012068 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
688245012069 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
688245012070 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
688245012071 Bacterial type II and III secretion system protein; Region: Secretin; cl02829
688245012072 SAF domain; Region: SAF; cl00555
688245012073 TadE-like protein; Region: TadE; pfam07811
688245012074 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
688245012075 non-specific DNA binding site; other site
688245012076 salt bridge; other site
688245012077 sequence-specific DNA binding site; other site
688245012078 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
688245012079 SEC-C motif; Region: SEC-C; cl12132
688245012080 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
688245012081 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808
688245012082 active site
688245012083 FMN binding site; other site
688245012084 substrate binding site; other site
688245012085 3Fe-4S cluster binding site; other site
688245012086 Protein Kinases, catalytic domain; Region: PKc_like; cl09925
688245012087 Sodium:dicarboxylate symporter family; Region: SDF; cl00573
688245012088 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
688245012089 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
688245012090 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
688245012091 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080
688245012092 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245012093 ATP binding site; other site
688245012094 Mg2+ binding site; other site
688245012095 G-X-G motif; other site
688245012096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245012097 active site
688245012098 phosphorylation site
688245012099 intermolecular recognition site; other site
688245012100 dimerization interface; other site
688245012101 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
688245012102 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
688245012103 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
688245012104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245012105 active site
688245012106 phosphorylation site
688245012107 intermolecular recognition site; other site
688245012108 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
688245012109 DNA binding residues
688245012110 dimerization interface; other site
688245012111 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245012112 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932
688245012113 FAD-dependent oxidoreductase; Provisional; Region: PRK08132
688245012114 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245012115 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245012116 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
688245012117 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245012118 Transcriptional regulator [Transcription]; Region: IclR; COG1414
688245012119 Bacterial transcriptional regulator; Region: IclR; pfam01614
688245012120 Transcriptional regulator [Transcription]; Region: IclR; COG1414
688245012121 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245012122 Bacterial transcriptional regulator; Region: IclR; pfam01614
688245012123 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245012124 Cytochrome P450; Region: p450; cl12078
688245012125 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
688245012126 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185
688245012127 FMN-binding pocket; other site
688245012128 flavin binding motif; other site
688245012129 phosphate binding motif; other site
688245012130 beta-alpha-beta structure motif; other site
688245012131 NAD binding pocket; other site
688245012132 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
688245012133 catalytic loop; other site
688245012134 iron binding site; other site
688245012135 UreD urease accessory protein; Region: UreD; cl00530
688245012136 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245012137 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
688245012138 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184
688245012139 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
688245012140 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
688245012141 Walker A/P-loop; other site
688245012142 ATP binding site; other site
688245012143 Q-loop/lid; other site
688245012144 ABC transporter signature motif; other site
688245012145 Walker B; other site
688245012146 D-loop; other site
688245012147 H-loop/switch region; other site
688245012148 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
688245012149 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219
688245012150 Walker A/P-loop; other site
688245012151 ATP binding site; other site
688245012152 Q-loop/lid; other site
688245012153 ABC transporter signature motif; other site
688245012154 Walker B; other site
688245012155 D-loop; other site
688245012156 H-loop/switch region; other site
688245012157 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
688245012158 TM-ABC transporter signature motif; other site
688245012159 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
688245012160 TM-ABC transporter signature motif; other site
688245012161 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
688245012162 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
688245012163 putative ligand binding site; other site
688245012164 Nickel uptake substrate-specific transmembrane region; Region: NikM; pfam10670
688245012165 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266
688245012166 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
688245012167 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel...; Region: ligand_gated_channel; cd01347
688245012168 N-terminal plug; other site
688245012169 ligand-binding site; other site
688245012170 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
688245012171 alpha-gamma subunit interface; other site
688245012172 beta-gamma subunit interface; other site
688245012173 HupE / UreJ protein; Region: HupE_UreJ; cl01011
688245012174 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_beta; cd00407
688245012175 gamma-beta subunit interface; other site
688245012176 alpha-beta subunit interface; other site
688245012177 LysE type translocator; Region: LysE; cl00565
688245012178 urease subunit alpha; Reviewed; Region: ureC; PRK13207
688245012179 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
688245012180 subunit interactions; other site
688245012181 active site
688245012182 flap region; other site
688245012183 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
688245012184 putative active site pocket; other site
688245012185 dimerization interface; other site
688245012186 putative catalytic residue; other site
688245012187 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The C...; Region: UreE; cd00571
688245012188 dimer interface; other site
688245012189 catalytic residues; other site
688245012190 UreF; Region: UreF; cl00531
688245012191 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
688245012192 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras; Region: Ras_like_GTPase; cl10444
688245012193 Acetyltransferases [General function prediction only]; Region: RimI; COG0456
688245012194 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
688245012195 Coenzyme A binding pocket; other site
688245012196 NeuB family; Region: NeuB; cl00496
688245012197 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
688245012198 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
688245012199 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
688245012200 PIN domain; Region: PIN; cl09128
688245012201 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
688245012202 THUMP domain; Region: THUMP; cl12076
688245012203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245012204 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
688245012205 dimer interface; other site
688245012206 putative tRNA-binding site; other site
688245012207 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
688245012208 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl01426
688245012209 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
688245012210 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
688245012211 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
688245012212 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
688245012213 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218
688245012214 Walker A/P-loop; other site
688245012215 ATP binding site; other site
688245012216 Q-loop/lid; other site
688245012217 ABC transporter signature motif; other site
688245012218 Walker B; other site
688245012219 D-loop; other site
688245012220 H-loop/switch region; other site
688245012221 OstA-like protein; Region: OstA; cl00844
688245012222 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
688245012223 catalytic residues; other site
688245012224 hinge region; other site
688245012225 alpha helical domain; other site
688245012226 Sporulation related domain; Region: SPOR; cl10051
688245012227 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
688245012228 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
688245012229 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
688245012230 active site
688245012231 HIGH motif; other site
688245012232 KMSK motif region; other site
688245012233 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
688245012234 tRNA binding surface; other site
688245012235 anticodon binding site; other site
688245012236 Predicted membrane protein (DUF2214); Region: DUF2214; cl01427
688245012237 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245012238 transcriptional activator TtdR; Provisional; Region: PRK09801
688245012239 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
688245012240 putative effector binding pocket; other site
688245012241 dimerization interface; other site
688245012242 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
688245012243 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245012244 ATP binding site; other site
688245012245 G-X-G motif; other site
688245012246 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
688245012247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245012248 active site
688245012249 phosphorylation site
688245012250 intermolecular recognition site; other site
688245012251 dimerization interface; other site
688245012252 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
688245012253 DNA binding site
688245012254 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl09155
688245012255 active site
688245012256 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
688245012257 active site 1
688245012258 dimer interface; other site
688245012259 hexamer interface; other site
688245012260 active site 2
688245012261 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
688245012262 active site 1
688245012263 dimer interface; other site
688245012264 hexamer interface; other site
688245012265 active site 2
688245012266 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
688245012267 putative active site; other site
688245012268 putative dimer interface; other site
688245012269 glutathione synthetase; Provisional; Region: PRK05246
688245012270 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
688245012271 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
688245012272 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
688245012273 Permease family; Region: Xan_ur_permease; cl00967
688245012274 K+ potassium transporter; Region: K_trans; cl01227
688245012275 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049
688245012276 Glutamate-cysteine ligase; Region: GshA; pfam08886
688245012277 Cation transport protein; Region: TrkH; cl10514
688245012278 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
688245012279 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
688245012280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245012281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245012282 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688245012283 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
688245012284 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
688245012285 putative catalytic cysteine; other site
688245012286 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
688245012287 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
688245012288 Rare lipoprotein B family; Region: RplB; cl01125
688245012289 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
688245012290 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
688245012291 HIGH motif; other site
688245012292 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
688245012293 KMSKS motif; other site
688245012294 active site
688245012295 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
688245012296 tRNA binding surface; other site
688245012297 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
688245012298 Mechanosensitive ion channel; Region: MS_channel; pfam00924
688245012299 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
688245012300 conserved cys residue; other site
688245012301 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321
688245012302 META domain; Region: META; cl01245
688245012303 Nuclease-related domain; Region: NERD; pfam08378
688245012304 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
688245012305 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
688245012306 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
688245012307 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
688245012308 Walker A/P-loop; other site
688245012309 ATP binding site; other site
688245012310 Q-loop/lid; other site
688245012311 ABC transporter signature motif; other site
688245012312 Walker B; other site
688245012313 D-loop; other site
688245012314 H-loop/switch region; other site
688245012315 AIR carboxylase; Region: AIRC; cl00310
688245012316 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
688245012317 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
688245012318 yrdC domain; Region: Sua5_yciO_yrdC; cl00305
688245012319 SUA5 domain; Region: SUA5; pfam03481
688245012320 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245012321 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
688245012322 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293
688245012323 Walker A/P-loop; other site
688245012324 ATP binding site; other site
688245012325 Q-loop/lid; other site
688245012326 ABC transporter signature motif; other site
688245012327 Walker B; other site
688245012328 D-loop; other site
688245012329 H-loop/switch region; other site
688245012330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688245012331 ABC-ATPase subunit interface; other site
688245012332 putative PBP binding loops; other site
688245012333 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245012334 active site
688245012335 Surface antigen; Region: Surface_Ag_2; cl01155
688245012336 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
688245012337 active site
688245012338 catalytic triad; other site
688245012339 oxyanion hole; other site
688245012340 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl03453
688245012341 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
688245012342 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00443
688245012343 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
688245012344 Uracil DNA glycosylase superfamily; Region: UDG; cl00483
688245012345 CorA-like Mg2+ transporter protein; Region: CorA; cl00459
688245012346 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
688245012347 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
688245012348 dimer interface; other site
688245012349 NADP binding site; other site
688245012350 catalytic residues; other site
688245012351 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
688245012352 Transcriptional regulators [Transcription]; Region: GntR; COG1802
688245012353 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688245012354 DNA binding site
688245012355 FCD domain; Region: FCD; cl11656
688245012356 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710
688245012357 DctM-like transporters; Region: DctM; pfam06808
688245012358 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688245012359 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
688245012360 potential frameshift: common BLAST hit: gi|115360848|ref|YP_777985.1| dihydrodipicolinate synthetase
688245012361 Dihydrodipicolinate synthase family. A member of the class I aldolases, which use an active-site lysine which stablilzes a reaction intermediate via Schiff base formation, and have TIM beta/alpha barrel fold. The dihydrodipicolinate synthase family...; Region: DHDPS-like; cd00408
688245012362 inhibitor site; inhibition site
688245012363 active site
688245012364 dimer interface; other site
688245012365 catalytic residue; other site
688245012366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245012367 Major Facilitator Superfamily; Region: MFS_1; pfam07690
688245012368 putative substrate translocation pore; other site
688245012369 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342
688245012370 trimer interface; other site
688245012371 eyelet of channel; other site
688245012372 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
688245012373 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron...; Region: PDR_like; cd06185
688245012374 FMN-binding pocket; other site
688245012375 flavin binding motif; other site
688245012376 phosphate binding motif; other site
688245012377 beta-alpha-beta structure motif; other site
688245012378 NAD binding pocket; other site
688245012379 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
688245012380 catalytic loop; other site
688245012381 iron binding site; other site
688245012382 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
688245012383 homotrimer interaction site; other site
688245012384 putative active site; other site
688245012385 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
688245012386 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
688245012387 [2Fe-2S] cluster binding site; other site
688245012388 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245012389 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
688245012390 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
688245012391 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
688245012392 NAD(P) binding site; other site
688245012393 catalytic residues; other site
688245012394 hypothetical protein; Provisional; Region: PRK07064
688245012395 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
688245012396 PYR/PP interface; other site
688245012397 dimer interface; other site
688245012398 TPP binding site; other site
688245012399 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
688245012400 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cd00568
688245012401 TPP-binding site; other site
688245012402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245012403 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
688245012404 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245012405 Transcriptional regulator [Transcription]; Region: IclR; COG1414
688245012406 Bacterial transcriptional regulator; Region: IclR; pfam01614
688245012407 short chain dehydrogenase; Provisional; Region: PRK12939
688245012408 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245012409 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
688245012410 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245012411 L-aspartate dehydrogenase; Provisional; Region: PRK13303
688245012412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245012413 Domain of unknown function DUF108; Region: DUF108; pfam01958
688245012414 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245012415 Transcriptional regulator [Transcription]; Region: IclR; COG1414
688245012416 Bacterial transcriptional regulator; Region: IclR; pfam01614
688245012417 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
688245012418 Cupin domain; Region: Cupin_2; cl09118
688245012419 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
688245012420 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245012421 tagatose-bisphosphate aldolase; Reviewed; Region: gatY; PRK09195
688245012422 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947
688245012423 intersubunit interface; other site
688245012424 active site
688245012425 zinc binding site; other site
688245012426 Na+ binding site; other site
688245012427 sensor protein QseC; Provisional; Region: PRK10337
688245012428 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
688245012429 dimer interface; other site
688245012430 phosphorylation site
688245012431 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245012432 ATP binding site; other site
688245012433 Mg2+ binding site; other site
688245012434 G-X-G motif; other site
688245012435 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
688245012436 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245012437 active site
688245012438 phosphorylation site
688245012439 intermolecular recognition site; other site
688245012440 dimerization interface; other site
688245012441 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
688245012442 DNA binding site
688245012443 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
688245012444 active site
688245012445 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
688245012446 active site
688245012447 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
688245012448 active site
688245012449 pyruvate kinase; Provisional; Region: PRK05826
688245012450 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl10032
688245012451 domain interfaces; other site
688245012452 active site
688245012453 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
688245012454 proline aminopeptidase P II; Provisional; Region: PRK10879
688245012455 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087
688245012456 active site
688245012457 Sulfite exporter TauE/SafE; Region: TauE; cl00498
688245012458 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
688245012459 Substrate binding site; other site
688245012460 metal-binding site
688245012461 transketolase; Reviewed; Region: PRK05899
688245012462 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
688245012463 TPP-binding site; other site
688245012464 dimer interface; other site
688245012465 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
688245012466 PYR/PP interface; other site
688245012467 dimer interface; other site
688245012468 TPP binding site; other site
688245012469 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
688245012470 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl12058
688245012471 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
688245012472 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
688245012473 Rhomboid family; Region: Rhomboid; cl11446
688245012474 OsmC-like protein; Region: OsmC; cl00767
688245012475 Pirin-related protein [General function prediction only]; Region: COG1741
688245012476 Cupin domain; Region: Cupin_2; cl09118
688245012477 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
688245012478 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
688245012479 Aspartase; Region: Aspartase; cd01357
688245012480 active sites
688245012481 tetramer interface; other site
688245012482 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
688245012483 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
688245012484 dihydrodipicolinate reductase; Provisional; Region: PRK00048
688245012485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245012486 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
688245012487 SmpA / OmlA family; Region: SmpA_OmlA; cl01095
688245012488 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
688245012489 metal binding site 2; metal-binding site
688245012490 putative DNA binding helix; other site
688245012491 metal binding site 1; metal-binding site
688245012492 dimer interface; other site
688245012493 structural Zn2+ binding site; other site
688245012494 Protein of unknown function (DUF1800); Region: DUF1800; cl02181
688245012495 Protein of unknown function (DUF1501); Region: DUF1501; cl01699
688245012496 HPr kinase/phosphorylase; Provisional; Region: PRK05428
688245012497 DRTGG domain; Region: DRTGG; cl12147
688245012498 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918
688245012499 Hpr binding site; other site
688245012500 active site
688245012501 homohexamer subunit interaction site; other site
688245012502 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
688245012503 active site
688245012504 phosphorylation site
688245012505 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552
688245012506 30S subunit binding site; other site
688245012507 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
688245012508 ATP binding site; other site
688245012509 active site
688245012510 phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959
688245012511 substrate binding site; other site
688245012512 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
688245012513 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245012514 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
688245012515 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10632
688245012516 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245012517 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
688245012518 putative effector binding pocket; other site
688245012519 dimerization interface; other site
688245012520 Pirin-related protein [General function prediction only]; Region: COG1741
688245012521 Cupin domain; Region: Cupin_2; cl09118
688245012522 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
688245012523 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
688245012524 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048
688245012525 C-terminal domain interface; other site
688245012526 GSH binding site (G-site); other site
688245012527 dimer interface; other site
688245012528 GST_C family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_C_Ure2p_like; cd03178
688245012529 dimer interface; other site
688245012530 N-terminal domain interface; other site
688245012531 putative substrate binding pocket (H-site); other site
688245012532 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245012533 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
688245012534 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245012535 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
688245012536 dimerization interface; other site
688245012537 substrate binding pocket; other site
688245012538 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245012539 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561
688245012540 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
688245012541 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
688245012542 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
688245012543 substrate binding pocket; other site
688245012544 membrane-bound complex binding site; other site
688245012545 hinge residues; other site
688245012546 DTW domain; Region: DTW; cl01221
688245012547 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451
688245012548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
688245012549 S-adenosylmethionine binding site; other site
688245012550 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
688245012551 Flavin Reductases; Region: FlaRed; cl00801
688245012552 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
688245012553 PAS fold; Region: PAS_3; pfam08447
688245012554 putative active site; other site
688245012555 heme pocket; other site
688245012556 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
688245012557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245012558 ATP binding site; other site
688245012559 Mg2+ binding site; other site
688245012560 G-X-G motif; other site
688245012561 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
688245012562 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
688245012563 putative NAD(P) binding site; other site
688245012564 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245012565 Isochorismatase family; Region: Isochorismatase; pfam00857
688245012566 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012
688245012567 catalytic triad; other site
688245012568 dimer interface; other site
688245012569 conserved cis-peptide bond; other site
688245012570 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012
688245012571 Isochorismatase family; Region: Isochorismatase; pfam00857
688245012572 catalytic triad; other site
688245012573 dimer interface; other site
688245012574 conserved cis-peptide bond; other site
688245012575 Pirin-related protein [General function prediction only]; Region: COG1741
688245012576 Cupin domain; Region: Cupin_2; cl09118
688245012577 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
688245012578 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245012579 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10632
688245012580 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
688245012581 putative effector binding pocket; other site
688245012582 putative dimerization interface; other site
688245012583 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340
688245012584 catalytic residues; other site
688245012585 dimer interface; other site
688245012586 Transglycosylase; Region: Transgly; cl07896
688245012587 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
688245012588 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
688245012589 Sodium:solute symporter family; Region: SSF; cl00456
688245012590 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a...; Region: RNase_Sa; cd00607
688245012591 active site
688245012592 barstar interaction site; other site
688245012593 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141
688245012594 putative RNAase interaction site; other site
688245012595 Integral membrane protein TerC family; Region: TerC; cl10468
688245012596 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
688245012597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245012598 active site
688245012599 phosphorylation site
688245012600 intermolecular recognition site; other site
688245012601 dimerization interface; other site
688245012602 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
688245012603 DNA binding residues
688245012604 dimerization interface; other site
688245012605 Histidine kinase; Region: HisKA_3; pfam07730
688245012606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245012607 ATP binding site; other site
688245012608 Mg2+ binding site; other site
688245012609 G-X-G motif; other site
688245012610 tRNA-specific 2-thiouridylase MnmA; Reviewed; Region: mnmA; PRK00143
688245012611 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998
688245012612 Ligand Binding Site; other site
688245012613 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
688245012614 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245012615 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
688245012616 putative dimerization interface; other site
688245012617 gluconate transporter; Region: gntP; TIGR00791
688245012618 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688245012619 tricarballylate dehydrogenase; Validated; Region: PRK08274
688245012620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245012621 CitB domain protein; Region: CitB; TIGR02484
688245012622 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245012623 Uncharacterized conserved protein [Function unknown]; Region: COG2128
688245012624 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
688245012625 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
688245012626 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
688245012627 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055
688245012628 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
688245012629 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
688245012630 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245012631 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245012632 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245012633 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245012634 dimerization interface; other site
688245012635 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
688245012636 EamA-like transporter family; Region: EamA; cl01037
688245012637 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X...; Region: Nudix_Hydrolase_2; cd03675
688245012638 nudix motif; other site
688245012639 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
688245012640 Coenzyme A binding pocket; other site
688245012641 Predicted membrane protein (DUF2061); Region: DUF2061; cl01257
688245012642 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
688245012643 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
688245012644 inhibitor-cofactor binding pocket; inhibition site
688245012645 pyridoxal 5'-phosphate binding site; other site
688245012646 catalytic residue; other site
688245012647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688245012648 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
688245012649 SurA N-terminal domain; Region: SurA_N; pfam09312
688245012650 PPIC-type PPIASE domain; Region: Rotamase; cl08278
688245012651 PPIC-type PPIASE domain; Region: Rotamase; cl08278
688245012652 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
688245012653 OstA-like protein; Region: OstA; cl00844
688245012654 Organic solvent tolerance protein; Region: OstA_C; pfam04453
688245012655 Protein Kinases, catalytic domain; Region: PKc_like; cl09925
688245012656 Phosphotransferase enzyme family; Region: APH; pfam01636
688245012657 RNA methyltransferase; Region: Methyltrans_RNA; cl00611
688245012658 Uncharacterized ACR, COG2135; Region: DUF159; cl03646
688245012659 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
688245012660 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245012661 Peptidase dimerization domain; Region: M20_dimer; cl09126
688245012662 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
688245012663 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
688245012664 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144
688245012665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
688245012666 S-adenosylmethionine binding site; other site
688245012667 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688245012668 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
688245012669 Predicted membrane protein [Function unknown]; Region: COG2119
688245012670 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
688245012671 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
688245012672 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590
688245012673 RNA/DNA binding site; other site
688245012674 RRM dimerization site; other site
688245012675 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590
688245012676 RNA/DNA binding site; other site
688245012677 RRM dimerization site; other site
688245012678 short chain dehydrogenase; Provisional; Region: PRK07024
688245012679 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245012680 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
688245012681 Protein of unknown function (DUF1239); Region: DUF1239; pfam06835
688245012682 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
688245012683 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
688245012684 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-...; Region: SIS_Kpsf; cd05014
688245012685 putative active site; other site
688245012686 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
688245012687 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
688245012688 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
688245012689 ligand binding site; other site
688245012690 flexible hinge region; other site
688245012691 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198
688245012692 substrate binding site; other site
688245012693 hinge regions; other site
688245012694 ADP binding site; other site
688245012695 catalytic site; other site
688245012696 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
688245012697 AzlC protein; Region: AzlC; cl00570
688245012698 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
688245012699 Formyl transferase; Region: Formyl_trans_N; cl00395
688245012700 Formyl transferase, C-terminal domain; Region: Formyl_trans_C; pfam02911
688245012701 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe...; Region: Pep_deformylase; cd00487
688245012702 active site
688245012703 catalytic residues; other site
688245012704 metal-binding site
688245012705 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
688245012706 putative peptidoglycan binding site; other site
688245012707 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
688245012708 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
688245012709 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
688245012710 Protein export membrane protein; Region: SecD_SecF; cl14618
688245012711 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
688245012712 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
688245012713 Protein export membrane protein; Region: SecD_SecF; cl14618
688245012714 Preprotein translocase subunit; Region: YajC; cl00806
688245012715 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
688245012716 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
688245012717 dimer interface; other site
688245012718 PYR/PP interface; other site
688245012719 TPP binding site; other site
688245012720 substrate binding site; other site
688245012721 TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as indolepyruvate or phenylpyruvate, which are generated by the...; Region: TPP_IOR_alpha; cd02008
688245012722 TPP-binding site; other site
688245012723 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
688245012724 Transcriptional regulators [Transcription]; Region: Lrp; COG1522
688245012725 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245012726 Bacterial protein of unknown function (DUF894); Region: DUF894; pfam05977
688245012727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245012728 putative substrate translocation pore; other site
688245012729 MltA specific insert domain; Region: MltA; pfam03562
688245012730 3D domain; Region: 3D; cl01439
688245012731 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
688245012732 ligand binding site; other site
688245012733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245012734 active site
688245012735 phosphorylation site
688245012736 intermolecular recognition site; other site
688245012737 dimerization interface; other site
688245012738 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
688245012739 DNA binding residues
688245012740 dimerization interface; other site
688245012741 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
688245012742 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
688245012743 putative active site; other site
688245012744 heme pocket; other site
688245012745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080
688245012746 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245012747 ATP binding site; other site
688245012748 Mg2+ binding site; other site
688245012749 G-X-G motif; other site
688245012750 Predicted amidohydrolase [General function prediction only]; Region: COG0388
688245012751 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
688245012752 putative active site; other site
688245012753 catalytic triad; other site
688245012754 dimer interface; other site
688245012755 conserved hypothetical protein TIGR02099; Region: TIGR02099
688245012756 hypothetical protein; Provisional; Region: PRK10899
688245012757 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
688245012758 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
688245012759 metal binding triad; other site
688245012760 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
688245012761 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
688245012762 metal binding triad; other site
688245012763 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
688245012764 putative glutathione S-transferase; Provisional; Region: PRK10357
688245012765 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
688245012766 putative C-terminal domain interface; other site
688245012767 putative GSH binding site (G-site); other site
688245012768 putative dimer interface; other site
688245012769 GST_C family, unknown subfamily 6; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_C_6; cd03205
688245012770 putative N-terminal domain interface; other site
688245012771 putative dimer interface; other site
688245012772 putative substrate binding pocket (H-site); other site
688245012773 adenylosuccinate lyase; Provisional; Region: PRK09285
688245012774 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
688245012775 tetramer interface; other site
688245012776 active site
688245012777 YaeQ protein; Region: YaeQ; cl01913
688245012778 Protein of unknown function (DUF3717); Region: DUF3717; pfam12512
688245012779 Protein of unknown function (DUF1289); Region: DUF1289; cl01304
688245012780 Integral membrane protein TerC family; Region: TerC; cl10468
688245012781 Membrane protein of unknown function; Region: DUF360; cl00850
688245012782 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
688245012783 Peptidase family M48; Region: Peptidase_M48; cl12018
688245012784 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420
688245012785 trimer interface; other site
688245012786 dimer interface; other site
688245012787 putative active site; other site
688245012788 O-Antigen ligase; Region: Wzy_C; cl04850
688245012789 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
688245012790 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
688245012791 Pilin (bacterial filament); Region: Pilin; pfam00114
688245012792 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
688245012793 phosphopeptide binding site; other site
688245012794 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
688245012795 dimer interface; other site
688245012796 ssDNA binding site; other site
688245012797 tetramer (dimer of dimers) interface; other site
688245012798 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245012799 putative substrate translocation pore; other site
688245012800 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
688245012801 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
688245012802 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
688245012803 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
688245012804 FAD dependent oxidoreductase; Region: DAO; pfam01266
688245012805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245012806 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245012807 Transcriptional regulator [Transcription]; Region: LysR; COG0583
688245012808 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245012809 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
688245012810 dimerization interface; other site
688245012811 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
688245012812 active site
688245012813 dimer interface; other site
688245012814 hypothetical protein; Provisional; Region: PRK11272
688245012815 EamA-like transporter family; Region: EamA; cl01037
688245012816 EamA-like transporter family; Region: EamA; cl01037
688245012817 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161
688245012818 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
688245012819 CoenzymeA binding site; other site
688245012820 subunit interaction site; other site
688245012821 PHB binding site; other site
688245012822 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
688245012823 DNA binding residues
688245012824 Integral membrane protein TerC family; Region: TerC; cl10468
688245012825 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
688245012826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245012827 CoA-ligase; Region: Ligase_CoA; pfam00549
688245012828 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
688245012829 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
688245012830 CoA-ligase; Region: Ligase_CoA; pfam00549
688245012831 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
688245012832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688245012833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688245012834 d-galactonate transporter; Region: 2A0114; TIGR00893
688245012835 putative substrate translocation pore; other site
688245012836 hypothetical protein; Provisional; Region: PRK11689
688245012837 EamA-like transporter family; Region: EamA; cl01037
688245012838 RecX family; Region: RecX; cl00936
688245012839 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
688245012840 recombinase A; Provisional; Region: recA; PRK09354
688245012841 hexamer interface; other site
688245012842 Walker A motif; other site
688245012843 ATP binding site; other site
688245012844 Walker B motif; other site
688245012845 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688245012846 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
688245012847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688245012848 active site
688245012849 phosphorylation site
688245012850 intermolecular recognition site; other site
688245012851 dimerization interface; other site
688245012852 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
688245012853 DNA binding site
688245012854 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
688245012855 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
688245012856 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
688245012857 dimer interface; other site
688245012858 phosphorylation site
688245012859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688245012860 ATP binding site; other site
688245012861 Mg2+ binding site; other site
688245012862 G-X-G motif; other site
688245012863 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688245012864 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
688245012865 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
688245012866 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
688245012867 SET domain; Region: SET; cl02566
688245012868 DNA topoisomerase III; Provisional; Region: PRK14724
688245012869 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by...; Region: TOPRIM_TopoIA_TopoIII; cd03362
688245012870 active site
688245012871 putative interdomain interaction site; other site
688245012872 putative metal-binding site; other site
688245012873 putative nucleotide binding site; other site
688245012874 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186
688245012875 domain I; other site
688245012876 DNA binding groove
688245012877 phosphate binding site; other site
688245012878 domain II; other site
688245012879 domain III; other site
688245012880 nucleotide binding site; other site
688245012881 catalytic site; other site
688245012882 domain IV; other site
688245012883 SWIB/MDM2 domain; Region: SWIB; cl02489
688245012884 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
688245012885 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
688245012886 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
688245012887 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
688245012888 putative ligand binding site; other site
688245012889 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
688245012890 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
688245012891 active site
688245012892 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
688245012893 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
688245012894 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053
688245012895 malic enzyme; Reviewed; Region: PRK12862
688245012896 Malic enzyme, N-terminal domain; Region: malic; pfam00390
688245012897 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
688245012898 putative NAD(P) binding site; other site
688245012899 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
688245012900 Sulfatase; Region: Sulfatase; cl10460
688245012901 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
688245012902 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
688245012903 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164
688245012904 G1 box; other site
688245012905 GTP/Mg2+ binding site; other site
688245012906 Switch I region; other site
688245012907 G2 box; other site
688245012908 Switch II region; other site
688245012909 G3 box; other site
688245012910 G4 box; other site
688245012911 G5 box; other site
688245012912 Uncharacterized conserved protein [Function unknown]; Region: COG4127
688245012913 Restriction endonuclease; Region: Mrr_cat; cl00747
688245012914 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01318
688245012915 60Kd inner membrane protein; Region: 60KD_IMP; cl00489
688245012916 Domain of unknown function DUF37; Region: DUF37; cl00506
688245012917 Ribonuclease P; Region: Ribonuclease_P; cl00457
688245012918 Ribosomal protein L34; Region: Ribosomal_L34; cl00370