-- dump date   	20140619_031844
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
759363000001	Uncharacterized conserved protein [Function unknown]; Region: COG2155
759363000002	Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721
759363000003	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
759363000004	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
759363000005	Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) [Translation, ribosomal structure and biogenesis]; Region: GatB; COG0064
759363000006	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
759363000007	GatB domain; Region: GatB_Yqey; pfam02637
759363000008	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
759363000009	ribonuclease HIII; Region: rnhC; TIGR00716
759363000010	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
759363000011	RNA/DNA hybrid binding site [nucleotide binding]; other site
759363000012	active site
759363000013	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
759363000014	Helix-turn-helix domain; Region: HTH_25; pfam13413
759363000015	lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK05906
759363000016	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
759363000017	putative acyl-acceptor binding pocket; other site
759363000018	Uncharacterized conserved protein [Function unknown]; Region: COG1624
759363000019	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
759363000020	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
759363000021	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
759363000022	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
759363000023	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
759363000024	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
759363000025	putative active site [active]
759363000026	PhoH-like protein; Region: PhoH; pfam02562
759363000027	Bacterial SH3 domain homologues; Region: SH3b; smart00287
759363000028	Bacterial SH3 domain homologues; Region: SH3b; smart00287
759363000029	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
759363000030	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
759363000031	HIGH motif; other site
759363000032	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
759363000033	active site
759363000034	KMSKS motif; other site
759363000035	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
759363000036	tRNA binding surface [nucleotide binding]; other site
759363000037	anticodon binding site; other site
759363000038	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
759363000039	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
759363000040	Catalytic site [active]
759363000041	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
759363000042	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
759363000043	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
759363000044	peptide chain release factor 1; Validated; Region: prfA; PRK00591
759363000045	PCRF domain; Region: PCRF; pfam03462
759363000046	RF-1 domain; Region: RF-1; pfam00472
759363000047	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
759363000048	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
759363000049	S-adenosylmethionine binding site [chemical binding]; other site
759363000050	signal recognition particle protein; Provisional; Region: PRK10867
759363000051	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
759363000052	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
759363000053	P loop; other site
759363000054	GTP binding site [chemical binding]; other site
759363000055	Signal peptide binding domain; Region: SRP_SPB; pfam02978
759363000056	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14522
759363000057	tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Reviewed; Region: trmD; PRK01037
759363000058	tRNA-(guanine-N1)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmD; COG0336
759363000059	ribosomal protein L19, bacterial type; Region: rplS_bact; TIGR01024
759363000060	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
759363000061	RNA/DNA hybrid binding site [nucleotide binding]; other site
759363000062	active site
759363000063	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
759363000064	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
759363000065	catalytic site [active]
759363000066	G-X2-G-X-G-K; other site
759363000067	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
759363000068	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
759363000069	active site
759363000070	HIGH motif; other site
759363000071	KMSKS motif; other site
759363000072	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
759363000073	tRNA binding surface [nucleotide binding]; other site
759363000074	anticodon binding site; other site
759363000075	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
759363000076	AAA domain; Region: AAA_30; pfam13604
759363000077	Family description; Region: UvrD_C_2; pfam13538
759363000078	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
759363000079	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
759363000080	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
759363000081	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
759363000082	trimer interface [polypeptide binding]; other site
759363000083	active site
759363000084	Holliday junction resolvasome, helicase subunit [DNA replication, recombination, and repair]; Region: RuvB; COG2255
759363000085	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
759363000086	Walker A motif; other site
759363000087	ATP binding site [chemical binding]; other site
759363000088	Walker B motif; other site
759363000089	arginine finger; other site
759363000090	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
759363000091	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
759363000092	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
759363000093	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
759363000094	active site
759363000095	catalytic site [active]
759363000096	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
759363000097	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
759363000098	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
759363000099	dimer interface [polypeptide binding]; other site
759363000100	ssDNA binding site [nucleotide binding]; other site
759363000101	tetramer (dimer of dimers) interface [polypeptide binding]; other site
759363000102	multifunctional aminopeptidase A; Provisional; Region: PRK00913
759363000103	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
759363000104	interface (dimer of trimers) [polypeptide binding]; other site
759363000105	Substrate-binding/catalytic site; other site
759363000106	Zn-binding sites [ion binding]; other site
759363000107	hypothetical protein; Provisional; Region: PRK05907
759363000108	Predicted methyltransferases [General function prediction only]; Region: COG0313
759363000109	Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649
759363000110	putative SAM binding site [chemical binding]; other site
759363000111	homodimer interface [polypeptide binding]; other site
759363000112	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cl00322
759363000113	coproporphyrinogen III oxidase; Provisional; Region: PRK06294
759363000114	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
759363000115	FeS/SAM binding site; other site
759363000116	HemN C-terminal domain; Region: HemN_C; pfam06969
759363000117	2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; Region: SucA; COG0567
759363000118	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
759363000119	TPP-binding site [chemical binding]; other site
759363000120	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
759363000121	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
759363000122	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
759363000123	E3 interaction surface; other site
759363000124	lipoyl attachment site [posttranslational modification]; other site
759363000125	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
759363000126	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
759363000127	uncharacterized protein, YfiH family; Region: TIGR00726
759363000128	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
759363000129	1-hydroxy-2-methyl-2-(e)-butenyl 4-diphosphate synthase [Lipid metabolism]; Region: gcpE; COG0821
759363000130	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749
759363000131	ADP-ribose binding site [chemical binding]; other site
759363000132	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
759363000133	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
759363000134	catalytic loop [active]
759363000135	iron binding site [ion binding]; other site
759363000136	type III secretion system protein; Validated; Region: PRK05910
759363000137	FHIPEP family; Region: FHIPEP; pfam00771
759363000138	RNA polymerase sigma factor sigma-28; Reviewed; Region: PRK05911
759363000139	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
759363000140	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
759363000141	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
759363000142	DNA binding residues [nucleotide binding]
759363000143	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
759363000144	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
759363000145	active site
759363000146	HIGH motif; other site
759363000147	dimer interface [polypeptide binding]; other site
759363000148	KMSKS motif; other site
759363000149	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
759363000150	RNA binding surface [nucleotide binding]; other site
759363000151	6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873
759363000152	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
759363000153	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
759363000154	GTP-binding protein LepA; Provisional; Region: PRK05433
759363000155	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
759363000156	G1 box; other site
759363000157	putative GEF interaction site [polypeptide binding]; other site
759363000158	GTP/Mg2+ binding site [chemical binding]; other site
759363000159	Switch I region; other site
759363000160	G2 box; other site
759363000161	G3 box; other site
759363000162	Switch II region; other site
759363000163	G4 box; other site
759363000164	G5 box; other site
759363000165	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
759363000166	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
759363000167	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
759363000168	ADP/ATP carrier protein family; Region: AAA; TIGR00769
759363000169	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
759363000170	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
759363000171	intersubunit interface [polypeptide binding]; other site
759363000172	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
759363000173	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
759363000174	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
759363000175	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
759363000176	ABC-ATPase subunit  interface; other site
759363000177	dimer interface [polypeptide binding]; other site
759363000178	putative PBP binding regions; other site
759363000179	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
759363000180	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
759363000181	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
759363000182	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
759363000183	ABC-ATPase subunit  interface; other site
759363000184	dimer interface [polypeptide binding]; other site
759363000185	putative PBP binding regions; other site
759363000186	1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743
759363000187	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
759363000188	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
759363000189	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
759363000190	RIP metalloprotease RseP; Region: TIGR00054
759363000191	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
759363000192	active site
759363000193	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
759363000194	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
759363000195	putative substrate binding region [chemical binding]; other site
759363000196	recF protein; Region: recf; TIGR00611
759363000197	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
759363000198	Walker A/P-loop; other site
759363000199	ATP binding site [chemical binding]; other site
759363000200	Q-loop/lid; other site
759363000201	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
759363000202	ABC transporter signature motif; other site
759363000203	Walker B; other site
759363000204	DNA polymerase III subunit beta; Validated; Region: PRK05643
759363000205	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
759363000206	putative DNA binding surface [nucleotide binding]; other site
759363000207	dimer interface [polypeptide binding]; other site
759363000208	beta-clamp/clamp loader binding surface; other site
759363000209	beta-clamp/translesion DNA polymerase binding surface; other site
759363000210	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
759363000211	SmpB-tmRNA interface; other site
759363000212	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
759363000213	ApbE family; Region: ApbE; pfam02424
759363000214	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14181
759363000215	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
759363000216	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
759363000217	homodimer interface [polypeptide binding]; other site
759363000218	NADP binding site [chemical binding]; other site
759363000219	substrate binding site [chemical binding]; other site
759363000220	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
759363000221	PLD-like domain; Region: PLDc_2; pfam13091
759363000222	putative active site [active]
759363000223	catalytic site [active]
759363000224	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
759363000225	PLD-like domain; Region: PLDc_2; pfam13091
759363000226	putative active site [active]
759363000227	catalytic site [active]
759363000228	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
759363000229	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
759363000230	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
759363000231	4-alpha-glucanotransferase; Region: Glyco_hydro_77; pfam02446
759363000232	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
759363000233	HrpJ-like domain; Region: HrpJ; cl15454
759363000234	Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789
759363000235	FHIPEP family; Region: FHIPEP; pfam00771
759363000236	type III secretion system protein; Validated; Region: PRK06298
759363000237	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
759363000238	GTP-binding protein YchF; Reviewed; Region: PRK09601
759363000239	YchF GTPase; Region: YchF; cd01900
759363000240	G1 box; other site
759363000241	GTP/Mg2+ binding site [chemical binding]; other site
759363000242	Switch I region; other site
759363000243	G2 box; other site
759363000244	Switch II region; other site
759363000245	G3 box; other site
759363000246	G4 box; other site
759363000247	G5 box; other site
759363000248	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
759363000249	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
759363000250	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
759363000251	active site
759363000252	Riboflavin kinase; Region: Flavokinase; smart00904
759363000253	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00989
759363000254	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
759363000255	RNA binding site [nucleotide binding]; other site
759363000256	active site
759363000257	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
759363000258	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
759363000259	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
759363000260	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
759363000261	G1 box; other site
759363000262	putative GEF interaction site [polypeptide binding]; other site
759363000263	GTP/Mg2+ binding site [chemical binding]; other site
759363000264	Switch I region; other site
759363000265	G2 box; other site
759363000266	G3 box; other site
759363000267	Switch II region; other site
759363000268	G4 box; other site
759363000269	G5 box; other site
759363000270	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
759363000271	Translation-initiation factor 2; Region: IF-2; pfam11987
759363000272	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
759363000273	transcription termination factor NusA; Region: NusA; TIGR01953
759363000274	NusA N-terminal domain; Region: NusA_N; pfam08529
759363000275	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
759363000276	RNA binding site [nucleotide binding]; other site
759363000277	homodimer interface [polypeptide binding]; other site
759363000278	NusA-like KH domain; Region: KH_5; pfam13184
759363000279	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
759363000280	G-X-X-G motif; other site
759363000281	ribosomal protein S1; Region: rpsA; TIGR00717
759363000282	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
759363000283	RNA binding site [nucleotide binding]; other site
759363000284	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
759363000285	RNA binding site [nucleotide binding]; other site
759363000286	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
759363000287	RNA binding site [nucleotide binding]; other site
759363000288	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
759363000289	RNA binding site [nucleotide binding]; other site
759363000290	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
759363000291	RNA binding site [nucleotide binding]; other site
759363000292	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
759363000293	RNA binding site [nucleotide binding]; other site
759363000294	domain interface; other site
759363000295	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
759363000296	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
759363000297	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
759363000298	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
759363000299	Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190
759363000300	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
759363000301	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
759363000302	active site
759363000303	motif I; other site
759363000304	motif II; other site
759363000305	enoyl-[acyl-carrier-protein] reductase; Region: PLN02730
759363000306	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
759363000307	NAD binding site [chemical binding]; other site
759363000308	homotetramer interface [polypeptide binding]; other site
759363000309	homodimer interface [polypeptide binding]; other site
759363000310	substrate binding site [chemical binding]; other site
759363000311	active site
759363000312	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
759363000313	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
759363000314	RNA binding surface [nucleotide binding]; other site
759363000315	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
759363000316	active site
759363000317	A/G-specific adenine glycosylase; Region: mutY; TIGR01084
759363000318	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
759363000319	minor groove reading motif; other site
759363000320	helix-hairpin-helix signature motif; other site
759363000321	substrate binding pocket [chemical binding]; other site
759363000322	active site
759363000323	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
759363000324	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
759363000325	DNA binding and oxoG recognition site [nucleotide binding]
759363000326	Uncharacterized conserved protein [Function unknown]; Region: COG0327
759363000327	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
759363000328	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
759363000329	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
759363000330	ring oligomerisation interface [polypeptide binding]; other site
759363000331	ATP/Mg binding site [chemical binding]; other site
759363000332	stacking interactions; other site
759363000333	hinge regions; other site
759363000334	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
759363000335	oligomerisation interface [polypeptide binding]; other site
759363000336	mobile loop; other site
759363000337	roof hairpin; other site
759363000338	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
759363000339	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
759363000340	active site
759363000341	Zn binding site [ion binding]; other site
759363000342	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
759363000343	Clp amino terminal domain; Region: Clp_N; pfam02861
759363000344	Clp amino terminal domain; Region: Clp_N; pfam02861
759363000345	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
759363000346	Walker A motif; other site
759363000347	ATP binding site [chemical binding]; other site
759363000348	Walker B motif; other site
759363000349	arginine finger; other site
759363000350	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
759363000351	Walker A motif; other site
759363000352	ATP binding site [chemical binding]; other site
759363000353	Walker B motif; other site
759363000354	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
759363000355	Uncharacterized conserved protein [Function unknown]; Region: COG2912
759363000356	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
759363000357	IncA protein; Region: IncA; pfam04156
759363000358	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
759363000359	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
759363000360	substrate binding site [chemical binding]; other site
759363000361	hexamer interface [polypeptide binding]; other site
759363000362	metal binding site [ion binding]; metal-binding site
759363000363	elongation factor P; Provisional; Region: PRK12426
759363000364	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
759363000365	RNA binding site [nucleotide binding]; other site
759363000366	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
759363000367	RNA binding site [nucleotide binding]; other site
759363000368	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
759363000369	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
759363000370	carboxyltransferase (CT) interaction site; other site
759363000371	biotinylation site [posttranslational modification]; other site
759363000372	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
759363000373	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
759363000374	ATP-grasp domain; Region: ATP-grasp_4; cl17255
759363000375	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
759363000376	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
759363000377	23S rRNA interface [nucleotide binding]; other site
759363000378	L3 interface [polypeptide binding]; other site
759363000379	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
759363000380	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
759363000381	NlpC/P60 family; Region: NLPC_P60; cl17555
759363000382	adenylate kinase; Reviewed; Region: adk; PRK00279
759363000383	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
759363000384	AMP-binding site [chemical binding]; other site
759363000385	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
759363000386	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
759363000387	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
759363000388	dimer interface [polypeptide binding]; other site
759363000389	conserved gate region; other site
759363000390	putative PBP binding loops; other site
759363000391	ABC-ATPase subunit interface; other site
759363000392	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
759363000393	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
759363000394	Walker A/P-loop; other site
759363000395	ATP binding site [chemical binding]; other site
759363000396	Q-loop/lid; other site
759363000397	ABC transporter signature motif; other site
759363000398	Walker B; other site
759363000399	D-loop; other site
759363000400	H-loop/switch region; other site
759363000401	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
759363000402	Methyltransferase domain; Region: Methyltransf_23; pfam13489
759363000403	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
759363000404	S-adenosylmethionine binding site [chemical binding]; other site
759363000405	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
759363000406	Serine hydrolase (FSH1); Region: FSH1; pfam03959
759363000407	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
759363000408	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
759363000409	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
759363000410	active site
759363000411	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
759363000412	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
759363000413	conserved hypothetical integral membrane protein; Region: TIGR00697
759363000414	Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318
759363000415	SEC-C motif; Region: SEC-C; pfam02810
759363000416	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
759363000417	Catalytic domain of Protein Kinases; Region: PKc; cd00180
759363000418	active site
759363000419	ATP binding site [chemical binding]; other site
759363000420	substrate binding site [chemical binding]; other site
759363000421	activation loop (A-loop); other site
759363000422	Uncharacterized conserved protein [Function unknown]; Region: COG1262
759363000423	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
759363000424	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
759363000425	DNA ligase, NAD-dependent; Region: dnlj; TIGR00575
759363000426	nucleotide binding pocket [chemical binding]; other site
759363000427	K-X-D-G motif; other site
759363000428	catalytic site [active]
759363000429	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
759363000430	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
759363000431	Helix-hairpin-helix motif; Region: HHH; pfam00633
759363000432	helix-hairpin-helix signature motif; other site
759363000433	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
759363000434	Dimer interface [polypeptide binding]; other site
759363000435	BRCT sequence motif; other site
759363000436	hypothetical protein; Provisional; Region: PRK06184
759363000437	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
759363000438	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
759363000439	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
759363000440	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
759363000441	FtsX-like permease family; Region: FtsX; pfam02687
759363000442	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
759363000443	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
759363000444	Walker A/P-loop; other site
759363000445	ATP binding site [chemical binding]; other site
759363000446	Q-loop/lid; other site
759363000447	ABC transporter signature motif; other site
759363000448	Walker B; other site
759363000449	D-loop; other site
759363000450	H-loop/switch region; other site
759363000451	membrane-attack complex / perforin; Region: MACPF; smart00457
759363000452	Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases; Region: MIR; smart00472
759363000453	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
759363000454	PLD-like domain; Region: PLDc_2; pfam13091
759363000455	putative active site [active]
759363000456	catalytic site [active]
759363000457	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
759363000458	PLD-like domain; Region: PLDc_2; pfam13091
759363000459	putative active site [active]
759363000460	catalytic site [active]
759363000461	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
759363000462	PLD-like domain; Region: PLDc_2; pfam13091
759363000463	putative active site [active]
759363000464	catalytic site [active]
759363000465	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
759363000466	PLD-like domain; Region: PLDc_2; pfam13091
759363000467	putative active site [active]
759363000468	catalytic site [active]
759363000469	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
759363000470	PLD-like domain; Region: PLDc_2; pfam13091
759363000471	putative active site [active]
759363000472	catalytic site [active]
759363000473	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
759363000474	PLD-like domain; Region: PLDc_2; pfam13091
759363000475	putative active site [active]
759363000476	catalytic site [active]
759363000477	PLD-like domain; Region: PLDc_2; pfam13091
759363000478	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
759363000479	putative active site [active]
759363000480	catalytic site [active]
759363000481	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
759363000482	PLD-like domain; Region: PLDc_2; pfam13091
759363000483	putative active site [active]
759363000484	catalytic site [active]
759363000485	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
759363000486	TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918
759363000487	TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919
759363000488	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
759363000489	Protein of unknown function (DUF3491); Region: DUF3491; pfam11996
759363000490	trp operon repressor, proteobacterial; Region: TrpR; TIGR01321
759363000491	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
759363000492	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
759363000493	pyridoxal 5'-phosphate binding site [chemical binding]; other site
759363000494	catalytic residue [active]
759363000495	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
759363000496	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
759363000497	substrate binding site [chemical binding]; other site
759363000498	active site
759363000499	catalytic residues [active]
759363000500	heterodimer interface [polypeptide binding]; other site
759363000501	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
759363000502	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
759363000503	peptide binding site [polypeptide binding]; other site
759363000504	putative disulfide oxidoreductase; Provisional; Region: PRK00611
759363000505	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
759363000506	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
759363000507	Thioredoxin; Region: Thioredoxin_4; cl17273
759363000508	Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729
759363000509	putative active site [active]
759363000510	redox center [active]
759363000511	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
759363000512	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
759363000513	Walker A/P-loop; other site
759363000514	ATP binding site [chemical binding]; other site
759363000515	Q-loop/lid; other site
759363000516	ABC transporter signature motif; other site
759363000517	Walker B; other site
759363000518	D-loop; other site
759363000519	H-loop/switch region; other site
759363000520	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
759363000521	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
759363000522	Ligand binding site; other site
759363000523	oligomer interface; other site
759363000524	CTP synthetase; Validated; Region: pyrG; PRK05380
759363000525	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
759363000526	Catalytic site [active]
759363000527	active site
759363000528	UTP binding site [chemical binding]; other site
759363000529	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
759363000530	active site
759363000531	putative oxyanion hole; other site
759363000532	catalytic triad [active]
759363000533	Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816
759363000534	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
759363000535	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
759363000536	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
759363000537	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
759363000538	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
759363000539	putative active site [active]
759363000540	DNA polymerase III subunit delta'; Validated; Region: PRK05917
759363000541	DNA polymerase III subunit delta'; Validated; Region: PRK08485
759363000542	thymidylate kinase; Validated; Region: tmk; PRK00698
759363000543	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
759363000544	TMP-binding site; other site
759363000545	ATP-binding site [chemical binding]; other site
759363000546	DNA gyrase, A subunit; Region: gyrA; TIGR01063
759363000547	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
759363000548	CAP-like domain; other site
759363000549	active site
759363000550	primary dimer interface [polypeptide binding]; other site
759363000551	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
759363000552	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
759363000553	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
759363000554	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
759363000555	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
759363000556	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
759363000557	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
759363000558	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
759363000559	ATP binding site [chemical binding]; other site
759363000560	Mg2+ binding site [ion binding]; other site
759363000561	G-X-G motif; other site
759363000562	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
759363000563	anchoring element; other site
759363000564	dimer interface [polypeptide binding]; other site
759363000565	ATP binding site [chemical binding]; other site
759363000566	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
759363000567	active site
759363000568	putative metal-binding site [ion binding]; other site
759363000569	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
759363000570	Protein of unknown function (DUF721); Region: DUF721; pfam05258
759363000571	queuine tRNA-ribosyltransferase; Provisional; Region: PRK01008
759363000572	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
759363000573	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
759363000574	MgtE intracellular N domain; Region: MgtE_N; pfam03448
759363000575	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
759363000576	Divalent cation transporter; Region: MgtE; pfam01769
759363000577	Metal-dependent proteases with possible chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: QRI7; COG0533
759363000578	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
759363000579	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
759363000580	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
759363000581	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
759363000582	peptide binding site [polypeptide binding]; other site
759363000583	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
759363000584	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
759363000585	dimer interface [polypeptide binding]; other site
759363000586	conserved gate region; other site
759363000587	putative PBP binding loops; other site
759363000588	ABC-ATPase subunit interface; other site
759363000589	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
759363000590	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
759363000591	dimer interface [polypeptide binding]; other site
759363000592	conserved gate region; other site
759363000593	putative PBP binding loops; other site
759363000594	ABC-ATPase subunit interface; other site
759363000595	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
759363000596	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
759363000597	Walker A/P-loop; other site
759363000598	ATP binding site [chemical binding]; other site
759363000599	Q-loop/lid; other site
759363000600	ABC transporter signature motif; other site
759363000601	Walker B; other site
759363000602	D-loop; other site
759363000603	H-loop/switch region; other site
759363000604	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
759363000605	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
759363000606	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
759363000607	Walker A/P-loop; other site
759363000608	ATP binding site [chemical binding]; other site
759363000609	Q-loop/lid; other site
759363000610	ABC transporter signature motif; other site
759363000611	Walker B; other site
759363000612	D-loop; other site
759363000613	H-loop/switch region; other site
759363000614	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
759363000615	Protein of unknown function (DUF1186); Region: DUF1186; pfam06685
759363000616	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
759363000617	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
759363000618	transmembrane helices; other site
759363000619	diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085
759363000620	active site
759363000621	ADP/pyrophosphate binding site [chemical binding]; other site
759363000622	dimerization interface [polypeptide binding]; other site
759363000623	allosteric effector site; other site
759363000624	fructose-1,6-bisphosphate binding site; other site
759363000625	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
759363000626	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
759363000627	diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085
759363000628	pyrophosphate-dependent phosphofructokinase; Region: PLN02251
759363000629	active site
759363000630	ADP/pyrophosphate binding site [chemical binding]; other site
759363000631	dimerization interface [polypeptide binding]; other site
759363000632	allosteric effector site; other site
759363000633	fructose-1,6-bisphosphate binding site; other site
759363000634	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
759363000635	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
759363000636	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
759363000637	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
759363000638	HIGH motif; other site
759363000639	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
759363000640	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
759363000641	active site
759363000642	KMSKS motif; other site
759363000643	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
759363000644	tRNA binding surface [nucleotide binding]; other site
759363000645	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00615
759363000646	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
759363000647	inhibitor-cofactor binding pocket; inhibition site
759363000648	pyridoxal 5'-phosphate binding site [chemical binding]; other site
759363000649	catalytic residue [active]
759363000650	Putative transcriptional regulator [Transcription]; Region: COG1678
759363000651	Uncharacterized conserved protein [Function unknown]; Region: COG1259
759363000652	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
759363000653	tetramer (dimer of dimers) interface [polypeptide binding]; other site
759363000654	active site
759363000655	dimer interface [polypeptide binding]; other site
759363000656	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
759363000657	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
759363000658	putative active site; other site
759363000659	catalytic residue [active]
759363000660	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
759363000661	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
759363000662	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
759363000663	Ligand Binding Site [chemical binding]; other site
759363000664	Predicted acid phosphatase [General function prediction only]; Region: SurE; COG0496
759363000665	prenyltransferase; Reviewed; Region: ubiA; PRK12876
759363000666	UbiA prenyltransferase family; Region: UbiA; pfam01040
759363000667	aromatic acid decarboxylase; Validated; Region: PRK05920
759363000668	Flavoprotein; Region: Flavoprotein; pfam02441
759363000669	Uncharacterized conserved protein [Function unknown]; Region: COG1284
759363000670	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
759363000671	IncA protein; Region: IncA; pfam04156
759363000672	IncA protein; Region: IncA; pfam04156
759363000673	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
759363000674	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
759363000675	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
759363000676	Na2 binding site [ion binding]; other site
759363000677	putative substrate binding site 1 [chemical binding]; other site
759363000678	Na binding site 1 [ion binding]; other site
759363000679	putative substrate binding site 2 [chemical binding]; other site
759363000680	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
759363000681	putative substrate translocation pore; other site
759363000682	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
759363000683	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
759363000684	ligand binding site [chemical binding]; other site
759363000685	flexible hinge region; other site
759363000686	acyl carrier protein; Provisional; Region: acpP; PRK00982
759363000687	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
759363000688	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
759363000689	NAD(P) binding site [chemical binding]; other site
759363000690	homotetramer interface [polypeptide binding]; other site
759363000691	homodimer interface [polypeptide binding]; other site
759363000692	active site
759363000693	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
759363000694	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
759363000695	3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747
759363000696	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
759363000697	dimer interface [polypeptide binding]; other site
759363000698	active site
759363000699	CoA binding pocket [chemical binding]; other site
759363000700	recombination protein RecR; Region: recR; TIGR00615
759363000701	RecR protein; Region: RecR; pfam02132
759363000702	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
759363000703	putative active site [active]
759363000704	putative metal-binding site [ion binding]; other site
759363000705	tetramer interface [polypeptide binding]; other site
759363000706	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
759363000707	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
759363000708	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
759363000709	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
759363000710	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
759363000711	Surface antigen; Region: Bac_surface_Ag; pfam01103
759363000712	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825
759363000713	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853
759363000714	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
759363000715	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
759363000716	trimer interface [polypeptide binding]; other site
759363000717	active site
759363000718	UDP-GlcNAc binding site [chemical binding]; other site
759363000719	lipid binding site [chemical binding]; lipid-binding site
759363000720	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
759363000721	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
759363000722	tetramer interface [polypeptide binding]; other site
759363000723	TPP-binding site [chemical binding]; other site
759363000724	heterodimer interface [polypeptide binding]; other site
759363000725	phosphorylation loop region [posttranslational modification]
759363000726	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
759363000727	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
759363000728	alpha subunit interface [polypeptide binding]; other site
759363000729	TPP binding site [chemical binding]; other site
759363000730	heterodimer interface [polypeptide binding]; other site
759363000731	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
759363000732	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
759363000733	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
759363000734	E3 interaction surface; other site
759363000735	lipoyl attachment site [posttranslational modification]; other site
759363000736	e3 binding domain; Region: E3_binding; pfam02817
759363000737	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
759363000738	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
759363000739	homodimer interface [polypeptide binding]; other site
759363000740	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
759363000741	active site pocket [active]
759363000742	chromosomal replication initiation protein; Provisional; Region: PRK12422
759363000743	DnaA N-terminal domain; Region: DnaA_N; pfam11638
759363000744	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
759363000745	Walker A motif; other site
759363000746	ATP binding site [chemical binding]; other site
759363000747	Walker B motif; other site
759363000748	arginine finger; other site
759363000749	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
759363000750	DnaA box-binding interface [nucleotide binding]; other site
759363000751	putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001
759363000752	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
759363000753	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
759363000754	CAAX protease self-immunity; Region: Abi; pfam02517
759363000755	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
759363000756	homodimer interface [polypeptide binding]; other site
759363000757	metal binding site [ion binding]; metal-binding site
759363000758	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
759363000759	Domain of unknown function DUF21; Region: DUF21; pfam01595
759363000760	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
759363000761	Transporter associated domain; Region: CorC_HlyC; smart01091
759363000762	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
759363000763	Domain of unknown function DUF21; Region: DUF21; pfam01595
759363000764	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
759363000765	Transporter associated domain; Region: CorC_HlyC; smart01091
759363000766	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
759363000767	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
759363000768	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
759363000769	catalytic residue [active]
759363000770	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
759363000771	Protein phosphatase 2C; Region: PP2C; pfam00481
759363000772	active site
759363000773	Uncharacterized conserved protein [Function unknown]; Region: COG5465
759363000774	DNA polymerase III subunit epsilon; Validated; Region: PRK06309
759363000775	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
759363000776	active site
759363000777	catalytic site [active]
759363000778	substrate binding site [chemical binding]; other site
759363000779	Protein of unknown function (DUF3820); Region: DUF3820; cl01411
759363000780	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107
759363000781	nucleosidase; Provisional; Region: PRK05634
759363000782	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
759363000783	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
759363000784	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
759363000785	Walker A/P-loop; other site
759363000786	ATP binding site [chemical binding]; other site
759363000787	Q-loop/lid; other site
759363000788	ABC transporter signature motif; other site
759363000789	Walker B; other site
759363000790	D-loop; other site
759363000791	H-loop/switch region; other site
759363000792	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
759363000793	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
759363000794	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
759363000795	IHF - DNA interface [nucleotide binding]; other site
759363000796	IHF dimer interface [polypeptide binding]; other site
759363000797	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
759363000798	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
759363000799	active site
759363000800	metal binding site [ion binding]; metal-binding site
759363000801	UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085
759363000802	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
759363000803	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
759363000804	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
759363000805	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
759363000806	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
759363000807	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
759363000808	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
759363000809	MraW methylase family; Region: Methyltransf_5; pfam01795
759363000810	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
759363000811	TPR motif; other site
759363000812	binding surface
759363000813	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
759363000814	DnaA N-terminal domain; Region: DnaA_N; pfam11638
759363000815	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
759363000816	Walker A motif; other site
759363000817	ATP binding site [chemical binding]; other site
759363000818	Walker B motif; other site
759363000819	arginine finger; other site
759363000820	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
759363000821	DnaA box-binding interface [nucleotide binding]; other site
759363000822	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK01024
759363000823	Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869
759363000824	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
759363000825	Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD [Energy production and conversion]; Region: NqrD; COG1347
759363000826	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK01061
759363000827	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
759363000828	lipoyl attachment site [posttranslational modification]; other site
759363000829	Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076
759363000830	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
759363000831	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
759363000832	putative active site [active]
759363000833	catalytic site [active]
759363000834	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
759363000835	putative active site [active]
759363000836	catalytic site [active]
759363000837	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
759363000838	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
759363000839	Clp amino terminal domain; Region: Clp_N; pfam02861
759363000840	Clp amino terminal domain; Region: Clp_N; pfam02861
759363000841	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
759363000842	Walker A motif; other site
759363000843	ATP binding site [chemical binding]; other site
759363000844	Walker B motif; other site
759363000845	arginine finger; other site
759363000846	UvrB/uvrC motif; Region: UVR; pfam02151
759363000847	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
759363000848	Walker A motif; other site
759363000849	ATP binding site [chemical binding]; other site
759363000850	Walker B motif; other site
759363000851	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
759363000852	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
759363000853	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
759363000854	Ligand Binding Site [chemical binding]; other site
759363000855	Helix-turn-helix domain; Region: HTH_17; pfam12728
759363000856	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
759363000857	active site
759363000858	phosphorylation site [posttranslational modification]
759363000859	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
759363000860	active site
759363000861	phosphorylation site [posttranslational modification]
759363000862	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
759363000863	trimer interface [polypeptide binding]; other site
759363000864	active site
759363000865	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
759363000866	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
759363000867	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
759363000868	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
759363000869	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
759363000870	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
759363000871	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
759363000872	active site
759363000873	substrate binding site [chemical binding]; other site
759363000874	metal binding site [ion binding]; metal-binding site
759363000875	ribonuclease III; Reviewed; Region: rnc; PRK00102
759363000876	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
759363000877	dimerization interface [polypeptide binding]; other site
759363000878	active site
759363000879	metal binding site [ion binding]; metal-binding site
759363000880	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
759363000881	dsRNA binding site [nucleotide binding]; other site
759363000882	DNA repair protein RadA; Provisional; Region: PRK11823
759363000883	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
759363000884	Walker A motif/ATP binding site; other site
759363000885	ATP binding site [chemical binding]; other site
759363000886	Walker B motif; other site
759363000887	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
759363000888	porphobilinogen deaminase; Provisional; Region: PRK01066
759363000889	Porphobilinogen deaminase, dipyromethane cofactor binding domain; Region: Porphobil_deam; pfam01379
759363000890	serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184
759363000891	Catalytic domain of Protein Kinases; Region: PKc; cd00180
759363000892	active site
759363000893	ATP binding site [chemical binding]; other site
759363000894	substrate binding site [chemical binding]; other site
759363000895	activation loop (A-loop); other site
759363000896	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
759363000897	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
759363000898	HIGH motif; other site
759363000899	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
759363000900	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
759363000901	active site
759363000902	KMSKS motif; other site
759363000903	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
759363000904	tRNA binding surface [nucleotide binding]; other site
759363000905	anticodon binding site; other site
759363000906	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
759363000907	V-type ATP synthase subunit K; Provisional; Region: PRK09621
759363000908	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
759363000909	V-type ATP synthase subunit I; Validated; Region: PRK05771
759363000910	Protein of unknown function (DUF1319); Region: DUF1319; pfam07028
759363000911	V-type ATP synthase subunit D; Provisional; Region: PRK02195
759363000912	V-type ATP synthase subunit B; Provisional; Region: PRK02118
759363000913	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
759363000914	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
759363000915	Walker A motif homologous position; other site
759363000916	Walker B motif; other site
759363000917	V-type ATP synthase subunit A; Provisional; Region: PRK04192
759363000918	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
759363000919	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
759363000920	Walker A motif/ATP binding site; other site
759363000921	Walker B motif; other site
759363000922	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
759363000923	Protein of unknown function (DUF2764); Region: DUF2764; pfam10962
759363000924	V-type ATP synthase subunit E; Provisional; Region: PRK01005
759363000925	V-type ATP synthase subunit E; Provisional; Region: PRK01558
759363000926	transaldolase-like protein; Provisional; Region: PTZ00411
759363000927	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
759363000928	active site
759363000929	dimer interface [polypeptide binding]; other site
759363000930	catalytic residue [active]
759363000931	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
759363000932	DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386
759363000933	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
759363000934	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
759363000935	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
759363000936	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
759363000937	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
759363000938	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
759363000939	DNA binding site [nucleotide binding]
759363000940	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
759363000941	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563
759363000942	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
759363000943	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
759363000944	DNA-directed RNA polymerase, beta subunit; Region: rpoB; TIGR02013
759363000945	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
759363000946	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
759363000947	RPB12 interaction site [polypeptide binding]; other site
759363000948	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
759363000949	RPB3 interaction site [polypeptide binding]; other site
759363000950	RPB1 interaction site [polypeptide binding]; other site
759363000951	RPB11 interaction site [polypeptide binding]; other site
759363000952	RPB10 interaction site [polypeptide binding]; other site
759363000953	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
759363000954	L11 interface [polypeptide binding]; other site
759363000955	putative EF-Tu interaction site [polypeptide binding]; other site
759363000956	putative EF-G interaction site [polypeptide binding]; other site
759363000957	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
759363000958	23S rRNA interface [nucleotide binding]; other site
759363000959	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
759363000960	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
759363000961	mRNA/rRNA interface [nucleotide binding]; other site
759363000962	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
759363000963	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
759363000964	putative thiostrepton binding site; other site
759363000965	23S rRNA interface [nucleotide binding]; other site
759363000966	L7/L12 interface [polypeptide binding]; other site
759363000967	L25 interface [polypeptide binding]; other site
759363000968	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
759363000969	transcription termination/antitermination factor NusG; Region: nusG; TIGR00922
759363000970	putative homodimer interface [polypeptide binding]; other site
759363000971	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
759363000972	heterodimer interface [polypeptide binding]; other site
759363000973	homodimer interface [polypeptide binding]; other site
759363000974	Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690
759363000975	elongation factor Tu; Reviewed; Region: PRK12735
759363000976	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
759363000977	G1 box; other site
759363000978	GEF interaction site [polypeptide binding]; other site
759363000979	GTP/Mg2+ binding site [chemical binding]; other site
759363000980	Switch I region; other site
759363000981	G2 box; other site
759363000982	G3 box; other site
759363000983	Switch II region; other site
759363000984	G4 box; other site
759363000985	G5 box; other site
759363000986	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
759363000987	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
759363000988	Antibiotic Binding Site [chemical binding]; other site
759363000989	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
759363000990	rRNA binding site [nucleotide binding]; other site
759363000991	predicted 30S ribosome binding site; other site
759363000992	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
759363000993	Protein of unknown function (DUF687); Region: DUF687; pfam05095
759363000994	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
759363000995	active site
759363000996	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
759363000997	triosephosphate isomerase; Provisional; Region: PRK14565
759363000998	substrate binding site [chemical binding]; other site
759363000999	dimer interface [polypeptide binding]; other site
759363001000	catalytic triad [active]
759363001001	Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570
759363001002	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
759363001003	generic binding surface II; other site
759363001004	generic binding surface I; other site
759363001005	Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154
759363001006	1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292
759363001007	TPP-binding site [chemical binding]; other site
759363001008	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
759363001009	PYR/PP interface [polypeptide binding]; other site
759363001010	dimer interface [polypeptide binding]; other site
759363001011	TPP binding site [chemical binding]; other site
759363001012	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
759363001013	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
759363001014	pyruvate kinase; Region: pyruv_kin; TIGR01064
759363001015	domain interfaces; other site
759363001016	active site
759363001017	excinuclease ABC subunit A; Provisional; Region: PRK00635
759363001018	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
759363001019	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
759363001020	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
759363001021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
759363001022	Walker A/P-loop; other site
759363001023	ATP binding site [chemical binding]; other site
759363001024	Q-loop/lid; other site
759363001025	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
759363001026	ABC transporter signature motif; other site
759363001027	Walker B; other site
759363001028	D-loop; other site
759363001029	H-loop/switch region; other site
759363001030	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
759363001031	Walker A/P-loop; other site
759363001032	ATP binding site [chemical binding]; other site
759363001033	Q-loop/lid; other site
759363001034	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
759363001035	Q-loop/lid; other site
759363001036	ABC transporter signature motif; other site
759363001037	Walker B; other site
759363001038	D-loop; other site
759363001039	H-loop/switch region; other site
759363001040	DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305
759363001041	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
759363001042	Walker A motif; other site
759363001043	ATP binding site [chemical binding]; other site
759363001044	Walker B motif; other site
759363001045	arginine finger; other site
759363001046	hypothetical protein; Validated; Region: PRK00153
759363001047	phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417
759363001048	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
759363001049	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
759363001050	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
759363001051	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
759363001052	dimerization domain swap beta strand [polypeptide binding]; other site
759363001053	regulatory protein interface [polypeptide binding]; other site
759363001054	active site
759363001055	regulatory phosphorylation site [posttranslational modification]; other site
759363001056	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
759363001057	Competence protein; Region: Competence; pfam03772
759363001058	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
759363001059	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
759363001060	tetramer interface [polypeptide binding]; other site
759363001061	TPP-binding site [chemical binding]; other site
759363001062	heterodimer interface [polypeptide binding]; other site
759363001063	phosphorylation loop region [posttranslational modification]
759363001064	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
759363001065	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
759363001066	alpha subunit interface [polypeptide binding]; other site
759363001067	TPP binding site [chemical binding]; other site
759363001068	heterodimer interface [polypeptide binding]; other site
759363001069	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
759363001070	chaperone protein DnaJ; Provisional; Region: PRK14284
759363001071	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
759363001072	HSP70 interaction site [polypeptide binding]; other site
759363001073	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
759363001074	Zn binding sites [ion binding]; other site
759363001075	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
759363001076	dimer interface [polypeptide binding]; other site
759363001077	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
759363001078	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
759363001079	Glycoprotease family; Region: Peptidase_M22; pfam00814
759363001080	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
759363001081	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
759363001082	Walker A motif; other site
759363001083	ATP binding site [chemical binding]; other site
759363001084	Walker B motif; other site
759363001085	arginine finger; other site
759363001086	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
759363001087	ribonuclease Z; Region: RNase_Z; TIGR02651
759363001088	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
759363001089	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
759363001090	active site
759363001091	Int/Topo IB signature motif; other site
759363001092	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
759363001093	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
759363001094	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
759363001095	ABC transporter; Region: ABC_tran_2; pfam12848
759363001096	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
759363001097	Maf-like protein; Region: Maf; pfam02545
759363001098	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
759363001099	active site
759363001100	dimer interface [polypeptide binding]; other site
759363001101	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
759363001102	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
759363001103	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
759363001104	active site
759363001105	catalytic residues [active]
759363001106	metal binding site [ion binding]; metal-binding site
759363001107	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
759363001108	dimethyladenosine transferase; Region: ksgA; TIGR00755
759363001109	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
759363001110	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
759363001111	catalytic residues [active]
759363001112	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
759363001113	dihydrodipicolinate synthase; Region: dapA; TIGR00674
759363001114	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
759363001115	inhibitor site; inhibition site
759363001116	active site
759363001117	dimer interface [polypeptide binding]; other site
759363001118	catalytic residue [active]
759363001119	aspartate kinase; Provisional; Region: PRK05925
759363001120	AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243
759363001121	putative catalytic residues [active]
759363001122	nucleotide binding site [chemical binding]; other site
759363001123	aspartate binding site [chemical binding]; other site
759363001124	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
759363001125	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
759363001126	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
759363001127	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
759363001128	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
759363001129	5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128
759363001130	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
759363001131	hinge; other site
759363001132	active site
759363001133	shikimate kinase; Provisional; Region: PRK00625
759363001134	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
759363001135	ADP binding site [chemical binding]; other site
759363001136	magnesium binding site [ion binding]; other site
759363001137	putative shikimate binding site; other site
759363001138	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
759363001139	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
759363001140	Tetramer interface [polypeptide binding]; other site
759363001141	active site
759363001142	FMN-binding site [chemical binding]; other site
759363001143	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
759363001144	active site
759363001145	dimer interface [polypeptide binding]; other site
759363001146	metal binding site [ion binding]; metal-binding site
759363001147	bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein; Reviewed; Region: aroDE; PRK09310
759363001148	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
759363001149	active site
759363001150	catalytic residue [active]
759363001151	dimer interface [polypeptide binding]; other site
759363001152	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
759363001153	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
759363001154	shikimate binding site; other site
759363001155	NAD(P) binding site [chemical binding]; other site
759363001156	Protein of unknown function (DUF2608); Region: DUF2608; pfam11019
759363001157	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
759363001158	Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) [Amino acid    transport and metabolism]; Region: COG1945
759363001159	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
759363001160	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
759363001161	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
759363001162	malate dehydrogenase; Provisional; Region: PRK05442
759363001163	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
759363001164	NAD(P) binding site [chemical binding]; other site
759363001165	dimer interface [polypeptide binding]; other site
759363001166	malate binding site [chemical binding]; other site
759363001167	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095
759363001168	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
759363001169	active site
759363001170	dimer interface [polypeptide binding]; other site
759363001171	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
759363001172	dimer interface [polypeptide binding]; other site
759363001173	active site
759363001174	GTPases [General function prediction only]; Region: HflX; COG2262
759363001175	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
759363001176	HflX GTPase family; Region: HflX; cd01878
759363001177	G1 box; other site
759363001178	GTP/Mg2+ binding site [chemical binding]; other site
759363001179	Switch I region; other site
759363001180	G2 box; other site
759363001181	G3 box; other site
759363001182	Switch II region; other site
759363001183	G4 box; other site
759363001184	G5 box; other site
759363001185	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
759363001186	putative hydrolase; Provisional; Region: PRK02113
759363001187	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
759363001188	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
759363001189	substrate binding pocket [chemical binding]; other site
759363001190	membrane-bound complex binding site; other site
759363001191	hinge residues; other site
759363001192	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876
759363001193	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
759363001194	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
759363001195	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
759363001196	nucleotide binding site/active site [active]
759363001197	Uncharacterized conserved protein related to MYG1 family [Function unknown]; Region: COG4286
759363001198	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
759363001199	hypothetical protein; Validated; Region: PRK00647
759363001200	Protein of unknown function (DUF1207); Region: DUF1207; pfam06727
759363001201	LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542
759363001202	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
759363001203	pyridoxal 5'-phosphate binding site [chemical binding]; other site
759363001204	homodimer interface [polypeptide binding]; other site
759363001205	catalytic residue [active]
759363001206	ABC transporter substrate binding protein; Region: ABC_sub_bind; pfam04392
759363001207	prolyl-tRNA synthetase; Provisional; Region: PRK09194
759363001208	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
759363001209	dimer interface [polypeptide binding]; other site
759363001210	motif 1; other site
759363001211	active site
759363001212	motif 2; other site
759363001213	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
759363001214	putative deacylase active site [active]
759363001215	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
759363001216	active site
759363001217	motif 3; other site
759363001218	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
759363001219	anticodon binding site; other site
759363001220	Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420
759363001221	GrpE; Region: GrpE; pfam01025
759363001222	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
759363001223	dimer interface [polypeptide binding]; other site
759363001224	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
759363001225	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
759363001226	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
759363001227	nucleotide binding site [chemical binding]; other site
759363001228	NEF interaction site [polypeptide binding]; other site
759363001229	SBD interface [polypeptide binding]; other site
759363001230	Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811
759363001231	Exoribonuclease R [Transcription]; Region: VacB; COG0557
759363001232	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
759363001233	RNB domain; Region: RNB; pfam00773
759363001234	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
759363001235	Putative zinc ribbon domain; Region: DUF164; pfam02591
759363001236	KpsF/GutQ family protein; Region: kpsF; TIGR00393
759363001237	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
759363001238	putative active site [active]
759363001239	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
759363001240	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
759363001241	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
759363001242	E3 interaction surface; other site
759363001243	lipoyl attachment site [posttranslational modification]; other site
759363001244	e3 binding domain; Region: E3_binding; pfam02817
759363001245	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
759363001246	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
759363001247	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
759363001248	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
759363001249	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
759363001250	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
759363001251	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
759363001252	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
759363001253	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
759363001254	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
759363001255	S-adenosylmethionine binding site [chemical binding]; other site
759363001256	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
759363001257	Lumazine binding domain; Region: Lum_binding; pfam00677
759363001258	Lumazine binding domain; Region: Lum_binding; pfam00677
759363001259	Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327
759363001260	ATP cone domain; Region: ATP-cone; pfam03477
759363001261	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
759363001262	Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597
759363001263	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
759363001264	amino acid carrier protein; Region: agcS; TIGR00835
759363001265	poly(A) polymerase; Region: pcnB; TIGR01942
759363001266	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
759363001267	active site
759363001268	NTP binding site [chemical binding]; other site
759363001269	metal binding triad [ion binding]; metal-binding site
759363001270	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
759363001271	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK01021
759363001272	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578
759363001273	Predicted membrane protein [Function unknown]; Region: COG3952
759363001274	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
759363001275	Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376
759363001276	Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548
759363001277	Autotransporter beta-domain; Region: Autotransporter; pfam03797
759363001278	Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548
759363001279	Autotransporter beta-domain; Region: Autotransporter; pfam03797
759363001280	Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548
759363001281	Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548
759363001282	Autotransporter beta-domain; Region: Autotransporter; pfam03797
759363001283	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
759363001284	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
759363001285	intersubunit interface [polypeptide binding]; other site
759363001286	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
759363001287	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
759363001288	Walker A/P-loop; other site
759363001289	ATP binding site [chemical binding]; other site
759363001290	Q-loop/lid; other site
759363001291	ABC transporter signature motif; other site
759363001292	Walker B; other site
759363001293	D-loop; other site
759363001294	H-loop/switch region; other site
759363001295	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
759363001296	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
759363001297	ABC-ATPase subunit  interface; other site
759363001298	dimer interface [polypeptide binding]; other site
759363001299	putative PBP binding regions; other site
759363001300	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
759363001301	Ribosomal protein L21 [Translation, ribosomal structure and biogenesis]; Region: RplU; COG0261
759363001302	Uncharacterized conserved protein [Function unknown]; Region: COG2928
759363001303	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319
759363001304	FOG: CBS domain [General function prediction only]; Region: COG0517
759363001305	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
759363001306	Transporter associated domain; Region: CorC_HlyC; smart01091
759363001307	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
759363001308	anti sigma factor interaction site; other site
759363001309	regulatory phosphorylation site [posttranslational modification]; other site
759363001310	Protein of unknown function (DUF3604); Region: DUF3604; pfam12228
759363001311	hypothetical protein; Provisional; Region: PRK05926
759363001312	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
759363001313	FeS/SAM binding site; other site
759363001314	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427
759363001315	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
759363001316	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
759363001317	S-adenosylmethionine binding site [chemical binding]; other site
759363001318	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
759363001319	Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682
759363001320	diaminopimelate epimerase; Region: DapF; TIGR00652
759363001321	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
759363001322	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
759363001323	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
759363001324	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
759363001325	oligomer interface [polypeptide binding]; other site
759363001326	active site residues [active]
759363001327	serine hydroxymethyltransferase; Provisional; Region: PRK13580
759363001328	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
759363001329	dimer interface [polypeptide binding]; other site
759363001330	active site
759363001331	glycine-pyridoxal phosphate binding site [chemical binding]; other site
759363001332	folate binding site [chemical binding]; other site
759363001333	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
759363001334	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
759363001335	active site
759363001336	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
759363001337	homotrimer interaction site [polypeptide binding]; other site
759363001338	zinc binding site [ion binding]; other site
759363001339	CDP-binding sites; other site
759363001340	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
759363001341	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
759363001342	FAD binding pocket [chemical binding]; other site
759363001343	conserved FAD binding motif [chemical binding]; other site
759363001344	phosphate binding motif [ion binding]; other site
759363001345	beta-alpha-beta structure motif; other site
759363001346	NAD binding pocket [chemical binding]; other site
759363001347	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
759363001348	elongation factor G; Reviewed; Region: PRK12739
759363001349	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
759363001350	G1 box; other site
759363001351	putative GEF interaction site [polypeptide binding]; other site
759363001352	GTP/Mg2+ binding site [chemical binding]; other site
759363001353	Switch I region; other site
759363001354	G2 box; other site
759363001355	G3 box; other site
759363001356	Switch II region; other site
759363001357	G4 box; other site
759363001358	G5 box; other site
759363001359	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
759363001360	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
759363001361	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
759363001362	30S ribosomal protein S7; Validated; Region: PRK05302
759363001363	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
759363001364	S17 interaction site [polypeptide binding]; other site
759363001365	S8 interaction site; other site
759363001366	16S rRNA interaction site [nucleotide binding]; other site
759363001367	streptomycin interaction site [chemical binding]; other site
759363001368	23S rRNA interaction site [nucleotide binding]; other site
759363001369	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
759363001370	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
759363001371	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
759363001372	protein binding site [polypeptide binding]; other site
759363001373	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
759363001374	Catalytic dyad [active]
759363001375	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
759363001376	Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA); Region: CRPA; pfam05745
759363001377	Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504
759363001378	Domain of unknown function DUF11; Region: DUF11; pfam01345
759363001379	Domain of unknown function DUF11; Region: DUF11; pfam01345
759363001380	Chlamydia cysteine-rich outer membrane protein 3; Region: Chlam_OMP3; pfam03503
759363001381	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
759363001382	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
759363001383	HIGH motif; other site
759363001384	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
759363001385	active site
759363001386	KMSKS motif; other site
759363001387	Helix-turn-helix domain; Region: HTH_17; pfam12728
759363001388	Helix-turn-helix domain; Region: HTH_17; pfam12728
759363001389	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
759363001390	DHH family; Region: DHH; pfam01368
759363001391	DHHA1 domain; Region: DHHA1; pfam02272
759363001392	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK12911
759363001393	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
759363001394	Protein export membrane protein; Region: SecD_SecF; pfam02355
759363001395	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14840
759363001396	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
759363001397	catalytic residue [active]
759363001398	putative FPP diphosphate  binding site; other site
759363001399	putative FPP binding hydrophobic cleft; other site
759363001400	dimer interface [polypeptide binding]; other site
759363001401	putative IPP diphosphate binding site; other site
759363001402	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
759363001403	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
759363001404	Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283
759363001405	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
759363001406	CMP-binding site; other site
759363001407	The sites determining sugar specificity; other site
759363001408	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
759363001409	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
759363001410	putative acyl-acceptor binding pocket; other site
759363001411	arginine-tRNA ligase; Region: PLN02286
759363001412	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
759363001413	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
759363001414	active site
759363001415	HIGH motif; other site
759363001416	KMSK motif region; other site
759363001417	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
759363001418	tRNA binding surface [nucleotide binding]; other site
759363001419	anticodon binding site; other site
759363001420	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
759363001421	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
759363001422	hinge; other site
759363001423	active site
759363001424	Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577
759363001425	Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577
759363001426	Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577
759363001427	DNA-binding regulatory protein, YebC/PmpR family; Region: TIGR01033
759363001428	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
759363001429	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
759363001430	Coenzyme A binding pocket [chemical binding]; other site
759363001431	PCRF domain; Region: PCRF; pfam03462
759363001432	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
759363001433	RF-1 domain; Region: RF-1; pfam00472
759363001434	SWIB-domain-containing proteins implicated in chromatin remodeling [Chromatin structure and dynamics]; Region: COG5531
759363001435	SWI complex, BAF60b domains; Region: SWIB; smart00151
759363001436	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
759363001437	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
759363001438	putative active site [active]
759363001439	putative metal binding site [ion binding]; other site
759363001440	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
759363001441	substrate binding site; other site
759363001442	dimer interface; other site
759363001443	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
759363001444	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
759363001445	dimerization interface 3.5A [polypeptide binding]; other site
759363001446	active site
759363001447	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
759363001448	PAS domain; Region: PAS; smart00091
759363001449	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
759363001450	dimer interface [polypeptide binding]; other site
759363001451	phosphorylation site [posttranslational modification]
759363001452	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
759363001453	ATP binding site [chemical binding]; other site
759363001454	Mg2+ binding site [ion binding]; other site
759363001455	G-X-G motif; other site
759363001456	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
759363001457	Response regulator receiver domain; Region: Response_reg; pfam00072
759363001458	active site
759363001459	phosphorylation site [posttranslational modification]
759363001460	intermolecular recognition site; other site
759363001461	dimerization interface [polypeptide binding]; other site
759363001462	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
759363001463	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
759363001464	Walker A motif; other site
759363001465	ATP binding site [chemical binding]; other site
759363001466	Walker B motif; other site
759363001467	arginine finger; other site
759363001468	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588
759363001469	Recombination protein O N terminal; Region: RecO_N; pfam11967
759363001470	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381
759363001471	Recombination protein O C terminal; Region: RecO_C; pfam02565
759363001472	Uncharacterized conserved protein [Function unknown]; Region: COG1723
759363001473	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
759363001474	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
759363001475	putative tRNA-binding site [nucleotide binding]; other site
759363001476	B3/4 domain; Region: B3_4; pfam03483
759363001477	tRNA synthetase B5 domain; Region: B5; pfam03484
759363001478	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
759363001479	dimer interface [polypeptide binding]; other site
759363001480	motif 1; other site
759363001481	motif 3; other site
759363001482	motif 2; other site
759363001483	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
759363001484	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
759363001485	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
759363001486	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
759363001487	DNA binding site [nucleotide binding]
759363001488	active site
759363001489	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
759363001490	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
759363001491	dimer interface [polypeptide binding]; other site
759363001492	conserved gate region; other site
759363001493	putative PBP binding loops; other site
759363001494	ABC-ATPase subunit interface; other site
759363001495	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
759363001496	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
759363001497	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
759363001498	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
759363001499	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
759363001500	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
759363001501	putative active site [active]
759363001502	putative metal binding site [ion binding]; other site
759363001503	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
759363001504	binding surface
759363001505	TPR motif; other site
759363001506	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
759363001507	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
759363001508	C-terminal domain interface [polypeptide binding]; other site
759363001509	active site
759363001510	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
759363001511	active site
759363001512	N-terminal domain interface [polypeptide binding]; other site
759363001513	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
759363001514	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
759363001515	substrate binding pocket [chemical binding]; other site
759363001516	membrane-bound complex binding site; other site
759363001517	hinge residues; other site
759363001518	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
759363001519	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
759363001520	S-adenosylmethionine binding site [chemical binding]; other site
759363001521	Predicted phosphohydrolase [General function prediction only]; Region: COG1768
759363001522	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
759363001523	ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448
759363001524	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
759363001525	ligand binding site; other site
759363001526	oligomer interface; other site
759363001527	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
759363001528	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
759363001529	N-terminal domain interface [polypeptide binding]; other site
759363001530	sulfate 1 binding site; other site
759363001531	transcription termination factor Rho; Region: rho; TIGR00767
759363001532	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
759363001533	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
759363001534	RNA binding site [nucleotide binding]; other site
759363001535	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
759363001536	multimer interface [polypeptide binding]; other site
759363001537	Walker A motif; other site
759363001538	ATP binding site [chemical binding]; other site
759363001539	Walker B motif; other site
759363001540	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
759363001541	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
759363001542	CoA-binding site [chemical binding]; other site
759363001543	ATP-binding [chemical binding]; other site
759363001544	DNA polymerase I; Provisional; Region: PRK05755
759363001545	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
759363001546	active site
759363001547	metal binding site 1 [ion binding]; metal-binding site
759363001548	putative 5' ssDNA interaction site; other site
759363001549	metal binding site 3; metal-binding site
759363001550	metal binding site 2 [ion binding]; metal-binding site
759363001551	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
759363001552	putative DNA binding site [nucleotide binding]; other site
759363001553	putative metal binding site [ion binding]; other site
759363001554	3'-5' exonuclease; Region: 35EXOc; smart00474
759363001555	active site
759363001556	substrate binding site [chemical binding]; other site
759363001557	catalytic site [active]
759363001558	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
759363001559	active site
759363001560	DNA binding site [nucleotide binding]
759363001561	catalytic site [active]
759363001562	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
759363001563	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
759363001564	tandem repeat interface [polypeptide binding]; other site
759363001565	oligomer interface [polypeptide binding]; other site
759363001566	active site residues [active]
759363001567	TLC ATP/ADP transporter; Region: TLC; pfam03219
759363001568	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
759363001569	replicative DNA helicase; Provisional; Region: PRK06321
759363001570	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
759363001571	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
759363001572	Walker A motif; other site
759363001573	ATP binding site [chemical binding]; other site
759363001574	Walker B motif; other site
759363001575	DNA binding loops [nucleotide binding]
759363001576	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
759363001577	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
759363001578	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
759363001579	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
759363001580	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
759363001581	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
759363001582	active site
759363001583	multimer interface [polypeptide binding]; other site
759363001584	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
759363001585	RuvA N terminal domain; Region: RuvA_N; pfam01330
759363001586	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
759363001587	active site
759363001588	putative DNA-binding cleft [nucleotide binding]; other site
759363001589	dimer interface [polypeptide binding]; other site
759363001590	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
759363001591	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
759363001592	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
759363001593	Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203
759363001594	DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027
759363001595	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
759363001596	alphaNTD - beta interaction site [polypeptide binding]; other site
759363001597	alphaNTD homodimer interface [polypeptide binding]; other site
759363001598	alphaNTD - beta' interaction site [polypeptide binding]; other site
759363001599	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
759363001600	30S ribosomal protein S11; Validated; Region: PRK05309
759363001601	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
759363001602	30S ribosomal protein S13; Region: bact_S13; TIGR03631
759363001603	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
759363001604	SecY translocase; Region: SecY; pfam00344
759363001605	ribosomal protein L15, bacterial/organelle; Region: rplO_bact; TIGR01071
759363001606	ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021
759363001607	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
759363001608	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
759363001609	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
759363001610	5S rRNA interface [nucleotide binding]; other site
759363001611	23S rRNA interface [nucleotide binding]; other site
759363001612	L5 interface [polypeptide binding]; other site
759363001613	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
759363001614	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
759363001615	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
759363001616	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
759363001617	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
759363001618	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
759363001619	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
759363001620	Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Region: RplX; COG0198
759363001621	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
759363001622	RNA binding site [nucleotide binding]; other site
759363001623	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
759363001624	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
759363001625	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
759363001626	23S rRNA interface [nucleotide binding]; other site
759363001627	putative translocon interaction site; other site
759363001628	signal recognition particle (SRP54) interaction site; other site
759363001629	L23 interface [polypeptide binding]; other site
759363001630	trigger factor interaction site; other site
759363001631	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
759363001632	23S rRNA interface [nucleotide binding]; other site
759363001633	5S rRNA interface [nucleotide binding]; other site
759363001634	putative antibiotic binding site [chemical binding]; other site
759363001635	L25 interface [polypeptide binding]; other site
759363001636	L27 interface [polypeptide binding]; other site
759363001637	ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009
759363001638	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
759363001639	G-X-X-G motif; other site
759363001640	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
759363001641	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
759363001642	putative translocon binding site; other site
759363001643	protein-rRNA interface [nucleotide binding]; other site
759363001644	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
759363001645	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
759363001646	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
759363001647	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
759363001648	Ribosomal protein L23 [Translation, ribosomal structure and biogenesis]; Region: RplW; COG0089
759363001649	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
759363001650	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
759363001651	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
759363001652	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
759363001653	putative active site [active]
759363001654	substrate binding site [chemical binding]; other site
759363001655	putative cosubstrate binding site; other site
759363001656	catalytic site [active]
759363001657	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
759363001658	substrate binding site [chemical binding]; other site
759363001659	Acyl-[acyl carrier protein]; Region: LpxA; COG1043
759363001660	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
759363001661	active site
759363001662	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
759363001663	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774
759363001664	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
759363001665	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
759363001666	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
759363001667	putative active site [active]
759363001668	catalytic triad [active]
759363001669	putative dimer interface [polypeptide binding]; other site
759363001670	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
759363001671	DNA polymerase III subunit epsilon; Validated; Region: PRK06310
759363001672	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
759363001673	active site
759363001674	catalytic site [active]
759363001675	substrate binding site [chemical binding]; other site
759363001676	Protein of unknown function (DUF3820); Region: DUF3820; cl01411
759363001677	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367
759363001678	Protein of unknown function (DUF2709); Region: DUF2709; pfam10915
759363001679	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
759363001680	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
759363001681	catalytic residues [active]
759363001682	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
759363001683	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
759363001684	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
759363001685	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
759363001686	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
759363001687	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
759363001688	dimer interface [polypeptide binding]; other site
759363001689	anticodon binding site; other site
759363001690	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
759363001691	homodimer interface [polypeptide binding]; other site
759363001692	motif 1; other site
759363001693	active site
759363001694	motif 2; other site
759363001695	GAD domain; Region: GAD; pfam02938
759363001696	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
759363001697	active site
759363001698	motif 3; other site
759363001699	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
759363001700	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
759363001701	dimer interface [polypeptide binding]; other site
759363001702	motif 1; other site
759363001703	active site
759363001704	motif 2; other site
759363001705	motif 3; other site
759363001706	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
759363001707	anticodon binding site; other site
759363001708	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
759363001709	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
759363001710	putative substrate translocation pore; other site
759363001711	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
759363001712	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
759363001713	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
759363001714	active site
759363001715	PHP Thumb interface [polypeptide binding]; other site
759363001716	metal binding site [ion binding]; metal-binding site
759363001717	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
759363001718	generic binding surface I; other site
759363001719	generic binding surface II; other site
759363001720	TPR repeat; Region: TPR_11; pfam13414
759363001721	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
759363001722	binding surface
759363001723	TPR motif; other site
759363001724	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
759363001725	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
759363001726	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
759363001727	Mg2+ binding site [ion binding]; other site
759363001728	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
759363001729	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
759363001730	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
759363001731	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
759363001732	S-adenosylmethionine binding site [chemical binding]; other site
759363001733	branched-chain amino acid uptake carrier; Region: livcs; TIGR00796
759363001734	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
759363001735	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
759363001736	ATP binding site [chemical binding]; other site
759363001737	putative Mg++ binding site [ion binding]; other site
759363001738	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
759363001739	ATP-binding site [chemical binding]; other site
759363001740	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
759363001741	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
759363001742	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
759363001743	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
759363001744	lipoate synthase; Region: lipA; TIGR00510
759363001745	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
759363001746	FeS/SAM binding site; other site
759363001747	Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669
759363001748	type III secretion system protein; Validated; Region: PRK06328
759363001749	Flagellar assembly protein FliH; Region: FliH; pfam02108
759363001750	type III secretion system protein; Reviewed; Region: PRK09617
759363001751	Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794
759363001752	Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791
759363001753	Protein of unknown function (DUF1494); Region: DUF1494; pfam07379
759363001754	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
759363001755	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
759363001756	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
759363001757	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
759363001758	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
759363001759	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
759363001760	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
759363001761	Walker A motif; other site
759363001762	ATP binding site [chemical binding]; other site
759363001763	Walker B motif; other site
759363001764	Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450
759363001765	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
759363001766	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
759363001767	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
759363001768	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
759363001769	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
759363001770	active site
759363001771	DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323
759363001772	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
759363001773	ATP binding site [chemical binding]; other site
759363001774	Mg2+ binding site [ion binding]; other site
759363001775	G-X-G motif; other site
759363001776	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
759363001777	ATP binding site [chemical binding]; other site
759363001778	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
759363001779	type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552
759363001780	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
759363001781	binding surface
759363001782	TPR motif; other site
759363001783	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
759363001784	EamA-like transporter family; Region: EamA; pfam00892
759363001785	EamA-like transporter family; Region: EamA; pfam00892
759363001786	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
759363001787	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cd01616
759363001788	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
759363001789	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
759363001790	active site
759363001791	dimer interface [polypeptide binding]; other site
759363001792	motif 1; other site
759363001793	motif 2; other site
759363001794	motif 3; other site
759363001795	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
759363001796	anticodon binding site; other site
759363001797	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
759363001798	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
759363001799	Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677
759363001800	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
759363001801	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
759363001802	active site
759363001803	HIGH motif; other site
759363001804	dimer interface [polypeptide binding]; other site
759363001805	KMSKS motif; other site
759363001806	excinuclease ABC subunit B; Provisional; Region: PRK05298
759363001807	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
759363001808	ATP binding site [chemical binding]; other site
759363001809	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
759363001810	nucleotide binding region [chemical binding]; other site
759363001811	ATP-binding site [chemical binding]; other site
759363001812	Ultra-violet resistance protein B; Region: UvrB; pfam12344
759363001813	enolase; Provisional; Region: eno; PRK00077
759363001814	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
759363001815	dimer interface [polypeptide binding]; other site
759363001816	metal binding site [ion binding]; metal-binding site
759363001817	substrate binding pocket [chemical binding]; other site
759363001818	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
759363001819	HAMP domain; Region: HAMP; pfam00672
759363001820	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
759363001821	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
759363001822	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
759363001823	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
759363001824	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
759363001825	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
759363001826	L-aspartate oxidase; Provisional; Region: PRK06175
759363001827	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
759363001828	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
759363001829	Iron-sulfur protein interface; other site
759363001830	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
759363001831	proximal heme binding site [chemical binding]; other site
759363001832	Iron-sulfur protein interface; other site
759363001833	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
759363001834	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
759363001835	active site
759363001836	Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233
759363001837	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
759363001838	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
759363001839	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
759363001840	DsbD alpha interface [polypeptide binding]; other site
759363001841	catalytic residues [active]
759363001842	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
759363001843	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
759363001844	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
759363001845	translocation protein TolB; Provisional; Region: tolB; PRK01029
759363001846	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
759363001847	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
759363001848	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
759363001849	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
759363001850	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
759363001851	ligand binding site [chemical binding]; other site
759363001852	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
759363001853	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
759363001854	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
759363001855	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
759363001856	dimer interface [polypeptide binding]; other site
759363001857	decamer (pentamer of dimers) interface [polypeptide binding]; other site
759363001858	catalytic triad [active]
759363001859	peroxidatic and resolving cysteines [active]
759363001860	Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459
759363001861	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
759363001862	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876
759363001863	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
759363001864	active site
759363001865	dimerization interface [polypeptide binding]; other site
759363001866	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
759363001867	ligand binding site [chemical binding]; other site
759363001868	active site
759363001869	UGI interface [polypeptide binding]; other site
759363001870	catalytic site [active]
759363001871	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
759363001872	Part of AAA domain; Region: AAA_19; pfam13245
759363001873	Family description; Region: UvrD_C_2; pfam13538
759363001874	DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog [Transcription]; Region: RpoN; COG1508
759363001875	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
759363001876	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
759363001877	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
759363001878	Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424
759363001879	GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478
759363001880	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
759363001881	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
759363001882	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
759363001883	folate binding site [chemical binding]; other site
759363001884	NADP+ binding site [chemical binding]; other site
759363001885	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
759363001886	catalytic center binding site [active]
759363001887	ATP binding site [chemical binding]; other site
759363001888	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
759363001889	dihydropteroate synthase; Region: DHPS; TIGR01496
759363001890	substrate binding pocket [chemical binding]; other site
759363001891	dimer interface [polypeptide binding]; other site
759363001892	inhibitor binding site; inhibition site
759363001893	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
759363001894	homooctamer interface [polypeptide binding]; other site
759363001895	active site
759363001896	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
759363001897	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
759363001898	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
759363001899	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
759363001900	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
759363001901	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
759363001902	DNA binding residues [nucleotide binding]
759363001903	Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785
759363001904	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
759363001905	Effector from type III secretion system; Region: Effector_1; pfam04518
759363001906	Effector from type III secretion system; Region: Effector_1; pfam04518
759363001907	Effector from type III secretion system; Region: Effector_1; pfam04518
759363001908	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
759363001909	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
759363001910	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
759363001911	MviN-like protein; Region: MVIN; pfam03023
759363001912	endonuclease IV; Provisional; Region: PRK01060
759363001913	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
759363001914	AP (apurinic/apyrimidinic) site pocket; other site
759363001915	DNA interaction; other site
759363001916	Metal-binding active site; metal-binding site
759363001917	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
759363001918	ribosomal protein S4, bacterial/organelle type; Region: rpsD_bact; TIGR01017
759363001919	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
759363001920	RNA binding surface [nucleotide binding]; other site
759363001921	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
759363001922	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
759363001923	active site residue [active]
759363001924	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
759363001925	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
759363001926	substrate binding pocket [chemical binding]; other site
759363001927	chain length determination region; other site
759363001928	substrate-Mg2+ binding site; other site
759363001929	catalytic residues [active]
759363001930	aspartate-rich region 1; other site
759363001931	active site lid residues [active]
759363001932	aspartate-rich region 2; other site
759363001933	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
759363001934	putative trimer interface [polypeptide binding]; other site
759363001935	putative CoA binding site [chemical binding]; other site
759363001936	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
759363001937	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
759363001938	DNA binding site [nucleotide binding]
759363001939	Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351
759363001940	Thymidylate synthase complementing protein; Region: Thy1; cl03630
759363001941	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
759363001942	dimer interface [polypeptide binding]; other site
759363001943	active site
759363001944	aspartate-rich active site metal binding site; other site
759363001945	allosteric magnesium binding site [ion binding]; other site
759363001946	Schiff base residues; other site
759363001947	NADH:ubiquinone oxidoreductase, Na(+)-translocating, A subunit; Region: nqrA; TIGR01936
759363001948	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
759363001949	transcript cleavage factor/unknown domain fusion protein; Validated; Region: PRK06330
759363001950	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
759363001951	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
759363001952	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
759363001953	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
759363001954	pyridoxal 5'-phosphate binding site [chemical binding]; other site
759363001955	homodimer interface [polypeptide binding]; other site
759363001956	catalytic residue [active]
759363001957	rod shape-determining protein MreC; Provisional; Region: PRK14872
759363001958	rod shape-determining protein MreC; Region: MreC; pfam04085
759363001959	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
759363001960	Part of AAA domain; Region: AAA_19; pfam13245
759363001961	Family description; Region: UvrD_C_2; pfam13538
759363001962	Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330
759363001963	Major Facilitator Superfamily; Region: MFS_1; pfam07690
759363001964	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
759363001965	putative substrate translocation pore; other site
759363001966	DNA topoisomerase I/SWI domain fusion protein; Validated; Region: PRK06319
759363001967	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
759363001968	active site
759363001969	interdomain interaction site; other site
759363001970	putative metal-binding site [ion binding]; other site
759363001971	nucleotide binding site [chemical binding]; other site
759363001972	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
759363001973	domain I; other site
759363001974	DNA binding groove [nucleotide binding]
759363001975	phosphate binding site [ion binding]; other site
759363001976	domain II; other site
759363001977	domain III; other site
759363001978	nucleotide binding site [chemical binding]; other site
759363001979	catalytic site [active]
759363001980	domain IV; other site
759363001981	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
759363001982	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
759363001983	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
759363001984	SWI complex, BAF60b domains; Region: SWIB; smart00151
759363001985	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
759363001986	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
759363001987	FMN binding site [chemical binding]; other site
759363001988	active site
759363001989	catalytic residues [active]
759363001990	substrate binding site [chemical binding]; other site
759363001991	Predicted integral membrane protein [Function unknown]; Region: COG0762
759363001992	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
759363001993	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
759363001994	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
759363001995	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
759363001996	recombinase A; Provisional; Region: recA; PRK09354
759363001997	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
759363001998	hexamer interface [polypeptide binding]; other site
759363001999	Walker A motif; other site
759363002000	ATP binding site [chemical binding]; other site
759363002001	Walker B motif; other site
759363002002	Protein of unknown function (DUF1347); Region: DUF1347; pfam07079
759363002003	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
759363002004	AAA domain; Region: AAA_30; pfam13604
759363002005	Family description; Region: UvrD_C_2; pfam13538
759363002006	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
759363002007	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
759363002008	Walker A/P-loop; other site
759363002009	ATP binding site [chemical binding]; other site
759363002010	Q-loop/lid; other site
759363002011	ABC transporter signature motif; other site
759363002012	Walker B; other site
759363002013	D-loop; other site
759363002014	H-loop/switch region; other site
759363002015	Protein of unknown function (DUF1137); Region: DUF1137; pfam06587
759363002016	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877
759363002017	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
759363002018	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
759363002019	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
759363002020	RNA binding surface [nucleotide binding]; other site
759363002021	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
759363002022	active site
759363002023	hypothetical protein; Provisional; Region: PRK01064
759363002024	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
759363002025	DNA topoisomerase IV subunit A; Provisional; Region: PRK09630
759363002026	DNA Topoisomerase IV; Region: TOP4c; smart00434
759363002027	CAP-like domain; other site
759363002028	active site
759363002029	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
759363002030	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
759363002031	ATP binding site [chemical binding]; other site
759363002032	Mg2+ binding site [ion binding]; other site
759363002033	G-X-G motif; other site
759363002034	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783
759363002035	ATP binding site [chemical binding]; other site
759363002036	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
759363002037	active site
759363002038	putative metal-binding site [ion binding]; other site
759363002039	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
759363002040	glutamyl-tRNA reductase; Validated; Region: hemA; PRK00676
759363002041	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
759363002042	NAD(P) binding pocket [chemical binding]; other site
759363002043	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
759363002044	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
759363002045	phosphopeptide binding site; other site
759363002046	MARCKS family; Region: MARCKS; pfam02063
759363002047	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
759363002048	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
759363002049	phosphopeptide binding site; other site
759363002050	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
759363002051	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
759363002052	binding surface
759363002053	Tetratricopeptide repeat; Region: TPR_16; pfam13432
759363002054	TPR motif; other site
759363002055	type III secretion system ATPase; Provisional; Region: PRK06315
759363002056	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
759363002057	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
759363002058	Walker A motif/ATP binding site; other site
759363002059	Walker B motif; other site
759363002060	type III secretion system protein; Validated; Region: PRK05933
759363002061	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
759363002062	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
759363002063	Catalytic domain of Protein Kinases; Region: PKc; cd00180
759363002064	active site
759363002065	ATP binding site [chemical binding]; other site
759363002066	substrate binding site [chemical binding]; other site
759363002067	activation loop (A-loop); other site
759363002068	Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450
759363002069	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
759363002070	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
759363002071	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
759363002072	Arginine kinase [Amino acid transport and metabolism]; Region: COG3869
759363002073	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
759363002074	ADP binding site [chemical binding]; other site
759363002075	phosphagen binding site; other site
759363002076	substrate specificity loop; other site
759363002077	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
759363002078	UvrB/uvrC motif; Region: UVR; pfam02151
759363002079	ribosome recycling factor; Reviewed; Region: frr; PRK00083
759363002080	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
759363002081	hinge region; other site
759363002082	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
759363002083	putative nucleotide binding site [chemical binding]; other site
759363002084	uridine monophosphate binding site [chemical binding]; other site
759363002085	homohexameric interface [polypeptide binding]; other site
759363002086	Translation elongation factor Ts [Translation, ribosomal structure and biogenesis]; Region: Tsf; COG0264
759363002087	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
759363002088	Elongation factor TS; Region: EF_TS; pfam00889
759363002089	Elongation factor TS; Region: EF_TS; pfam00889
759363002090	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
759363002091	rRNA interaction site [nucleotide binding]; other site
759363002092	S8 interaction site; other site
759363002093	putative laminin-1 binding site; other site
759363002094	Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308
759363002095	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
759363002096	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
759363002097	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
759363002098	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
759363002099	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
759363002100	TPR motif; other site
759363002101	Tetratricopeptide repeat; Region: TPR_16; pfam13432
759363002102	binding surface
759363002103	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
759363002104	binding surface
759363002105	TPR motif; other site
759363002106	TPR repeat; Region: TPR_11; pfam13414
759363002107	TPR repeat; Region: TPR_11; pfam13414
759363002108	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
759363002109	binding surface
759363002110	TPR motif; other site
759363002111	TPR repeat; Region: TPR_11; pfam13414
759363002112	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
759363002113	putative ABC transporter; Region: ycf24; CHL00085
759363002114	FeS assembly ATPase SufC; Region: sufC; TIGR01978
759363002115	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
759363002116	Walker A/P-loop; other site
759363002117	ATP binding site [chemical binding]; other site
759363002118	Q-loop/lid; other site
759363002119	ABC transporter signature motif; other site
759363002120	Walker B; other site
759363002121	D-loop; other site
759363002122	H-loop/switch region; other site
759363002123	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
759363002124	FeS assembly protein SufD; Region: sufD; TIGR01981
759363002125	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
759363002126	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
759363002127	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
759363002128	catalytic residue [active]
759363002129	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
759363002130	ParB-like nuclease domain; Region: ParBc; pfam02195
759363002131	KorB domain; Region: KorB; pfam08535
759363002132	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
759363002133	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
759363002134	Walker A/P-loop; other site
759363002135	ATP binding site [chemical binding]; other site
759363002136	Q-loop/lid; other site
759363002137	ABC transporter signature motif; other site
759363002138	Walker B; other site
759363002139	D-loop; other site
759363002140	H-loop/switch region; other site
759363002141	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
759363002142	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
759363002143	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
759363002144	Walker A/P-loop; other site
759363002145	ATP binding site [chemical binding]; other site
759363002146	Q-loop/lid; other site
759363002147	ABC transporter signature motif; other site
759363002148	Walker B; other site
759363002149	D-loop; other site
759363002150	H-loop/switch region; other site
759363002151	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
759363002152	Protein of unknown function DUF47; Region: PhoU_div; pfam01865
759363002153	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
759363002154	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
759363002155	Phosphoglycerate kinase; Region: PGK; pfam00162
759363002156	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
759363002157	substrate binding site [chemical binding]; other site
759363002158	hinge regions; other site
759363002159	ADP binding site [chemical binding]; other site
759363002160	catalytic site [active]
759363002161	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
759363002162	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
759363002163	minor groove reading motif; other site
759363002164	helix-hairpin-helix signature motif; other site
759363002165	substrate binding pocket [chemical binding]; other site
759363002166	active site
759363002167	Predicted GTPase [General function prediction only]; Region: ThdF; COG0486
759363002168	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
759363002169	trmE is a tRNA modification GTPase; Region: trmE; cd04164
759363002170	G1 box; other site
759363002171	GTP/Mg2+ binding site [chemical binding]; other site
759363002172	Switch I region; other site
759363002173	G2 box; other site
759363002174	Switch II region; other site
759363002175	G3 box; other site
759363002176	G4 box; other site
759363002177	G5 box; other site
759363002178	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
759363002179	phosphatidylserine decarboxylase; Provisional; Region: PRK00723
759363002180	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
759363002181	binding surface
759363002182	TPR motif; other site
759363002183	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899
759363002184	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
759363002185	ATP binding site [chemical binding]; other site
759363002186	putative Mg++ binding site [ion binding]; other site
759363002187	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
759363002188	Predicted GTPases [General function prediction only]; Region: COG1160
759363002189	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
759363002190	G1 box; other site
759363002191	GTP/Mg2+ binding site [chemical binding]; other site
759363002192	Switch I region; other site
759363002193	G2 box; other site
759363002194	Switch II region; other site
759363002195	G3 box; other site
759363002196	G4 box; other site
759363002197	G5 box; other site
759363002198	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
759363002199	G1 box; other site
759363002200	GTP/Mg2+ binding site [chemical binding]; other site
759363002201	Switch I region; other site
759363002202	G2 box; other site
759363002203	G3 box; other site
759363002204	Switch II region; other site
759363002205	G4 box; other site
759363002206	G5 box; other site
759363002207	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
759363002208	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
759363002209	active site
759363002210	NTP binding site [chemical binding]; other site
759363002211	metal binding triad [ion binding]; metal-binding site
759363002212	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
759363002213	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
759363002214	ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994
759363002215	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
759363002216	Walker A motif; other site
759363002217	ATP binding site [chemical binding]; other site
759363002218	Walker B motif; other site
759363002219	arginine finger; other site
759363002220	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
759363002221	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
759363002222	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
759363002223	oligomer interface [polypeptide binding]; other site
759363002224	active site residues [active]
759363002225	FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544
759363002226	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
759363002227	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
759363002228	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
759363002229	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
759363002230	ATP binding site [chemical binding]; other site
759363002231	putative Mg++ binding site [ion binding]; other site
759363002232	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
759363002233	nucleotide binding region [chemical binding]; other site
759363002234	ATP-binding site [chemical binding]; other site
759363002235	rod shape-determining protein MreB; Provisional; Region: PRK13927
759363002236	MreB and similar proteins; Region: MreB_like; cd10225
759363002237	nucleotide binding site [chemical binding]; other site
759363002238	Mg binding site [ion binding]; other site
759363002239	putative protofilament interaction site [polypeptide binding]; other site
759363002240	RodZ interaction site [polypeptide binding]; other site
759363002241	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
759363002242	active site
759363002243	substrate-binding site [chemical binding]; other site
759363002244	metal-binding site [ion binding]
759363002245	GTP binding site [chemical binding]; other site
759363002246	Effector from type III secretion system; Region: Effector_1; pfam04518
759363002247	Effector from type III secretion system; Region: Effector_1; pfam04518
759363002248	Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308
759363002249	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240
759363002250	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
759363002251	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
759363002252	UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284
759363002253	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
759363002254	active site
759363002255	sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053
759363002256	type III secretion system ATPase; Validated; Region: PRK05922
759363002257	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
759363002258	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
759363002259	Walker A motif; other site
759363002260	ATP binding site [chemical binding]; other site
759363002261	Walker B motif; other site
759363002262	type III secretion system protein; Validated; Region: PRK05934
759363002263	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
759363002264	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
759363002265	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
759363002266	active site
759363002267	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
759363002268	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
759363002269	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
759363002270	catalytic residue [active]
759363002271	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
759363002272	catalytic core [active]
759363002273	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
759363002274	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
759363002275	RNA binding surface [nucleotide binding]; other site
759363002276	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
759363002277	active site
759363002278	biotin--protein ligase; Provisional; Region: PRK05935
759363002279	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
759363002280	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
759363002281	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
759363002282	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
759363002283	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
759363002284	motif II; other site
759363002285	CCC1-related protein family; Region: CCC1_like_1; cd02437
759363002286	seryl-tRNA synthetase; Provisional; Region: PRK05431
759363002287	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
759363002288	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
759363002289	dimer interface [polypeptide binding]; other site
759363002290	active site
759363002291	motif 1; other site
759363002292	motif 2; other site
759363002293	motif 3; other site
759363002294	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
759363002295	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
759363002296	catalytic motif [active]
759363002297	Zn binding site [ion binding]; other site
759363002298	RibD C-terminal domain; Region: RibD_C; pfam01872
759363002299	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
759363002300	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
759363002301	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
759363002302	dimerization interface [polypeptide binding]; other site
759363002303	active site
759363002304	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
759363002305	homopentamer interface [polypeptide binding]; other site
759363002306	active site
759363002307	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
759363002308	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
759363002309	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
759363002310	substrate binding site [chemical binding]; other site
759363002311	Proteins containing SET domain [General function prediction only]; Region: COG2940
759363002312	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317
759363002313	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
759363002314	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
759363002315	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
759363002316	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
759363002317	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
759363002318	Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Region: NqrF; COG2871
759363002319	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
759363002320	catalytic loop [active]
759363002321	iron binding site [ion binding]; other site
759363002322	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
759363002323	FAD binding pocket [chemical binding]; other site
759363002324	FAD binding motif [chemical binding]; other site
759363002325	phosphate binding motif [ion binding]; other site
759363002326	beta-alpha-beta structure motif; other site
759363002327	NAD binding pocket [chemical binding]; other site
759363002328	preprotein translocase, YajC subunit; Region: yajC; TIGR00739
759363002329	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
759363002330	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
759363002331	S-adenosylmethionine binding site [chemical binding]; other site
759363002332	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
759363002333	binding surface
759363002334	TPR motif; other site
759363002335	Tetratricopeptide repeat; Region: TPR_12; pfam13424
759363002336	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
759363002337	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
759363002338	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
759363002339	HemN C-terminal domain; Region: HemN_C; pfam06969
759363002340	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
759363002341	substrate binding site [chemical binding]; other site
759363002342	active site
759363002343	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
759363002344	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
759363002345	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
759363002346	ATP binding site [chemical binding]; other site
759363002347	putative Mg++ binding site [ion binding]; other site
759363002348	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
759363002349	nucleotide binding region [chemical binding]; other site
759363002350	ATP-binding site [chemical binding]; other site
759363002351	TRCF domain; Region: TRCF; pfam03461
759363002352	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
759363002353	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
759363002354	motif 1; other site
759363002355	active site
759363002356	motif 2; other site
759363002357	motif 3; other site
759363002358	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
759363002359	DHHA1 domain; Region: DHHA1; pfam02272
759363002360	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
759363002361	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
759363002362	TPP-binding site [chemical binding]; other site
759363002363	dimer interface [polypeptide binding]; other site
759363002364	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
759363002365	PYR/PP interface [polypeptide binding]; other site
759363002366	dimer interface [polypeptide binding]; other site
759363002367	TPP binding site [chemical binding]; other site
759363002368	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
759363002369	AMP nucleosidase, putative; Region: AMN-like; TIGR01721
759363002370	elongation factor P; Validated; Region: PRK00529
759363002371	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
759363002372	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
759363002373	RNA binding site [nucleotide binding]; other site
759363002374	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
759363002375	RNA binding site [nucleotide binding]; other site
759363002376	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
759363002377	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
759363002378	putative active site [active]
759363002379	putative metal binding site [ion binding]; other site
759363002380	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
759363002381	active site
759363002382	metal binding site [ion binding]; metal-binding site
759363002383	Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459
759363002384	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
759363002385	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
759363002386	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
759363002387	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
759363002388	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
759363002389	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
759363002390	Mg++ binding site [ion binding]; other site
759363002391	putative catalytic motif [active]
759363002392	putative substrate binding site [chemical binding]; other site
759363002393	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00683
759363002394	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
759363002395	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
759363002396	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
759363002397	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
759363002398	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
759363002399	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
759363002400	cell division protein FtsW; Region: ftsW; TIGR02614
759363002401	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133
759363002402	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
759363002403	active site
759363002404	homodimer interface [polypeptide binding]; other site
759363002405	bifunctional D-alanyl-alanine synthetase A/UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: PRK14573
759363002406	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
759363002407	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
759363002408	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
759363002409	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
759363002410	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
759363002411	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
759363002412	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cd02409
759363002413	G-X-X-G motif; other site
759363002414	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
759363002415	anti sigma factor interaction site; other site
759363002416	regulatory phosphorylation site [posttranslational modification]; other site
759363002417	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
759363002418	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
759363002419	hypothetical protein; Provisional; Region: PRK05927
759363002420	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
759363002421	FeS/SAM binding site; other site
759363002422	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
759363002423	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
759363002424	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333
759363002425	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
759363002426	dimer interface [polypeptide binding]; other site
759363002427	active site
759363002428	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428
759363002429	active site
759363002430	Ap4A binding cleft/pocket [chemical binding]; other site
759363002431	P4 phosphate binding site; other site
759363002432	nudix motif; other site
759363002433	putative P2/P3 phosphate binding site [ion binding]; other site
759363002434	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
759363002435	dimer interface [polypeptide binding]; other site
759363002436	substrate binding site [chemical binding]; other site
759363002437	metal binding sites [ion binding]; metal-binding site
759363002438	PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517
759363002439	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
759363002440	active site
759363002441	putative lithium-binding site [ion binding]; other site
759363002442	substrate binding site [chemical binding]; other site
759363002443	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
759363002444	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
759363002445	putative acyl-acceptor binding pocket; other site
759363002446	long chain fatty acid--[acyl-carrier-protein] ligase; Validated; Region: PRK06334
759363002447	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
759363002448	acyl-activating enzyme (AAE) consensus motif; other site
759363002449	AMP binding site [chemical binding]; other site
759363002450	active site
759363002451	CoA binding site [chemical binding]; other site
759363002452	8-amino-7-oxononanoate synthase; Provisional; Region: PRK05937
759363002453	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
759363002454	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
759363002455	catalytic residue [active]
759363002456	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
759363002457	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
759363002458	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
759363002459	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
759363002460	dimer interface [polypeptide binding]; other site
759363002461	putative anticodon binding site; other site
759363002462	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
759363002463	motif 1; other site
759363002464	dimer interface [polypeptide binding]; other site
759363002465	active site
759363002466	motif 2; other site
759363002467	motif 3; other site
759363002468	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
759363002469	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
759363002470	active site
759363002471	HIGH motif; other site
759363002472	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
759363002473	KMSKS motif; other site
759363002474	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
759363002475	tRNA binding surface [nucleotide binding]; other site
759363002476	anticodon binding site; other site
759363002477	Thioredoxin-like; Region: Thioredoxin_7; pfam13899
759363002478	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
759363002479	ribonuclease P; Reviewed; Region: rnpA; PRK00730
759363002480	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
759363002481	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
759363002482	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
759363002483	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
759363002484	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
759363002485	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
759363002486	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
759363002487	GIY-YIG motif/motif A; other site
759363002488	active site
759363002489	catalytic site [active]
759363002490	putative DNA binding site [nucleotide binding]; other site
759363002491	metal binding site [ion binding]; metal-binding site
759363002492	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
759363002493	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
759363002494	MutS domain I; Region: MutS_I; pfam01624
759363002495	MutS domain II; Region: MutS_II; pfam05188
759363002496	MutS domain III; Region: MutS_III; pfam05192
759363002497	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
759363002498	Walker A/P-loop; other site
759363002499	ATP binding site [chemical binding]; other site
759363002500	Q-loop/lid; other site
759363002501	ABC transporter signature motif; other site
759363002502	Walker B; other site
759363002503	D-loop; other site
759363002504	H-loop/switch region; other site
759363002505	DNA primase; Validated; Region: dnaG; PRK05667
759363002506	CHC2 zinc finger; Region: zf-CHC2; pfam01807
759363002507	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
759363002508	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
759363002509	active site
759363002510	metal binding site [ion binding]; metal-binding site
759363002511	interdomain interaction site; other site
759363002512	glycyl-tRNA synthetase; Provisional; Region: PRK14908
759363002513	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
759363002514	dimer interface [polypeptide binding]; other site
759363002515	motif 1; other site
759363002516	active site
759363002517	motif 2; other site
759363002518	motif 3; other site
759363002519	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
759363002520	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
759363002521	glycogen synthase; Provisional; Region: glgA; PRK00654
759363002522	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
759363002523	ADP-binding pocket [chemical binding]; other site
759363002524	homodimer interface [polypeptide binding]; other site
759363002525	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
759363002526	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
759363002527	5S rRNA interface [nucleotide binding]; other site
759363002528	CTC domain interface [polypeptide binding]; other site
759363002529	L16 interface [polypeptide binding]; other site
759363002530	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
759363002531	putative active site [active]
759363002532	catalytic residue [active]
759363002533	Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360
759363002534	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
759363002535	Ribosomal protein L9 [Translation, ribosomal structure and biogenesis]; Region: RplI; COG0359
759363002536	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
759363002537	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
759363002538	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK00650
759363002539	Protein of unknown function (DUF1504); Region: DUF1504; pfam07399
759363002540	Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025
759363002541	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
759363002542	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
759363002543	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
759363002544	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
759363002545	putative acyl-acceptor binding pocket; other site
759363002546	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
759363002547	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
759363002548	homodimer interface [polypeptide binding]; other site
759363002549	oligonucleotide binding site [chemical binding]; other site
759363002550	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
759363002551	putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13846
759363002552	Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548
759363002553	Autotransporter beta-domain; Region: Autotransporter; pfam03797
759363002554	IncA protein; Region: IncA; pfam04156
759363002555	YtxH-like protein; Region: YtxH; pfam12732
759363002556	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314
759363002557	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
759363002558	active site
759363002559	substrate binding site [chemical binding]; other site
759363002560	metal binding site [ion binding]; metal-binding site
759363002561	glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135
759363002562	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
759363002563	glutaminase active site [active]
759363002564	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
759363002565	dimer interface [polypeptide binding]; other site
759363002566	active site
759363002567	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
759363002568	dimer interface [polypeptide binding]; other site
759363002569	active site
759363002570	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222
759363002571	aromatic amino acid transport protein; Region: araaP; TIGR00837
759363002572	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222
759363002573	aromatic amino acid transport protein; Region: araaP; TIGR00837
759363002574	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
759363002575	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
759363002576	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
759363002577	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
759363002578	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
759363002579	succinyl-CoA synthetase, beta subunit; Region: sucCoAbeta; TIGR01016
759363002580	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
759363002581	CoA-ligase; Region: Ligase_CoA; pfam00549
759363002582	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
759363002583	CoA binding domain; Region: CoA_binding; smart00881
759363002584	CoA-ligase; Region: Ligase_CoA; pfam00549
759363002585	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
759363002586	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
759363002587	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
759363002588	protein binding site [polypeptide binding]; other site
759363002589	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
759363002590	protein binding site [polypeptide binding]; other site
759363002591	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
759363002592	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
759363002593	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
759363002594	Peptidase M16C associated; Region: M16C_assoc; pfam08367
759363002595	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
759363002596	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
759363002597	RmuC family; Region: RmuC; pfam02646
759363002598	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
759363002599	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
759363002600	ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12365
759363002601	ATP cone domain; Region: ATP-cone; pfam03477
759363002602	ATP cone domain; Region: ATP-cone; pfam03477
759363002603	Class I ribonucleotide reductase; Region: RNR_I; cd01679
759363002604	active site
759363002605	dimer interface [polypeptide binding]; other site
759363002606	catalytic residues [active]
759363002607	effector binding site; other site
759363002608	R2 peptide binding site; other site
759363002609	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
759363002610	dimer interface [polypeptide binding]; other site
759363002611	putative radical transfer pathway; other site
759363002612	diiron center [ion binding]; other site
759363002613	tyrosyl radical; other site
759363002614	Putative methyltransferase; Region: Methyltransf_4; pfam02390
759363002615	Methyltransferase domain; Region: Methyltransf_18; pfam12847
759363002616	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
759363002617	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
759363002618	FAD binding domain; Region: FAD_binding_4; pfam01565
759363002619	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
759363002620	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
759363002621	putative RNA binding site [nucleotide binding]; other site
759363002622	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
759363002623	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
759363002624	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
759363002625	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
759363002626	23S rRNA binding site [nucleotide binding]; other site
759363002627	L21 binding site [polypeptide binding]; other site
759363002628	L13 binding site [polypeptide binding]; other site
759363002629	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
759363002630	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
759363002631	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
759363002632	motif 1; other site
759363002633	dimer interface [polypeptide binding]; other site
759363002634	active site
759363002635	motif 2; other site
759363002636	motif 3; other site
759363002637	Predicted permeases [General function prediction only]; Region: COG0795
759363002638	Predicted permeases [General function prediction only]; Region: COG0795
759363002639	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
759363002640	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
759363002641	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
759363002642	Ligand Binding Site [chemical binding]; other site
759363002643	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
759363002644	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
759363002645	Walker A motif; other site
759363002646	ATP binding site [chemical binding]; other site
759363002647	Walker B motif; other site
759363002648	arginine finger; other site
759363002649	Peptidase family M41; Region: Peptidase_M41; pfam01434
759363002650	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
759363002651	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
759363002652	RNase E interface [polypeptide binding]; other site
759363002653	trimer interface [polypeptide binding]; other site
759363002654	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
759363002655	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
759363002656	RNase E interface [polypeptide binding]; other site
759363002657	trimer interface [polypeptide binding]; other site
759363002658	active site
759363002659	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
759363002660	putative nucleic acid binding region [nucleotide binding]; other site
759363002661	G-X-X-G motif; other site
759363002662	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
759363002663	RNA binding site [nucleotide binding]; other site
759363002664	domain interface; other site
759363002665	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
759363002666	16S/18S rRNA binding site [nucleotide binding]; other site
759363002667	S13e-L30e interaction site [polypeptide binding]; other site
759363002668	25S rRNA binding site [nucleotide binding]; other site
759363002669	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
759363002670	nucleoside/Zn binding site; other site
759363002671	dimer interface [polypeptide binding]; other site
759363002672	catalytic motif [active]
759363002673	Protein of unknown function (DUF720); Region: DUF720; pfam05302
759363002674	Protein of unknown function (DUF720); Region: DUF720; pfam05302
759363002675	Protein of unknown function (DUF720); Region: DUF720; pfam05302
759363002676	methionine aminopeptidase; Provisional; Region: PRK12318
759363002677	SEC-C motif; Region: SEC-C; pfam02810
759363002678	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
759363002679	active site
759363002680	MarC family integral membrane protein; Region: MarC; pfam01914
759363002681	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
759363002682	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
759363002683	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
759363002684	dimer interface [polypeptide binding]; other site
759363002685	conserved gate region; other site
759363002686	putative PBP binding loops; other site
759363002687	ABC-ATPase subunit interface; other site
759363002688	NMT1/THI5 like; Region: NMT1; pfam09084
759363002689	fumarate hydratase, class II; Region: fumC_II; TIGR00979
759363002690	Class II fumarases; Region: Fumarase_classII; cd01362
759363002691	active site
759363002692	tetramer interface [polypeptide binding]; other site
759363002693	high affinity sulphate transporter 1; Region: sulP; TIGR00815
759363002694	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
759363002695	Sulfate transporter family; Region: Sulfate_transp; pfam00916
759363002696	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
759363002697	Na+/H+ antiporter, NhaD family; Region: NhaD; TIGR00775
759363002698	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
759363002699	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
759363002700	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
759363002701	Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563
759363002702	active site triad [active]
759363002703	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
759363002704	LytB protein; Region: LYTB; pfam02401
759363002705	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
759363002706	type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552
759363002707	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
759363002708	binding surface
759363002709	TPR motif; other site
759363002710	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
759363002711	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
759363002712	active site
759363002713	DNA binding site [nucleotide binding]
759363002714	Int/Topo IB signature motif; other site
759363002715	glycogen branching enzyme; Provisional; Region: PRK05402
759363002716	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
759363002717	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
759363002718	active site
759363002719	catalytic site [active]
759363002720	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
759363002721	Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784
759363002722	Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784
759363002723	Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376
759363002724	Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548
759363002725	Autotransporter beta-domain; Region: Autotransporter; pfam03797
759363002726	Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376
759363002727	Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548
759363002728	Autotransporter beta-domain; Region: Autotransporter; pfam03797
759363002729	Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548
759363002730	Autotransporter beta-domain; Region: Autotransporter; pfam03797
759363002731	Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376
759363002732	Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548
759363002733	Autotransporter beta-domain; Region: Autotransporter; pfam03797
759363002734	Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376
759363002735	Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376
759363002736	Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376
759363002737	Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548
759363002738	Autotransporter beta-domain; Region: Autotransporter; pfam03797
759363002739	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
759363002740	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
759363002741	active site
759363002742	Int/Topo IB signature motif; other site
759363002743	catalytic residues [active]
759363002744	DNA binding site [nucleotide binding]
759363002745	Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677
759363002746	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
759363002747	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
759363002748	P-loop; other site
759363002749	Magnesium ion binding site [ion binding]; other site
759363002750	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
759363002751	Magnesium ion binding site [ion binding]; other site
759363002752	Chlamydia virulence protein PGP3-D; Region: Chlam_vir; pfam05475
759363002753	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
759363002754	DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
759363002755	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
759363002756	Walker A motif; other site
759363002757	ATP binding site [chemical binding]; other site
759363002758	Walker B motif; other site
759363002759	DNA binding loops [nucleotide binding]
759363002760	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
759363002761	active site
759363002762	catalytic residues [active]
759363002763	DNA binding site [nucleotide binding]
759363002764	Int/Topo IB signature motif; other site