-- dump date 20140619_031546 -- class Genbank::misc_feature -- table misc_feature_note -- id note 580047000001 Uncharacterized conserved protein [Function unknown]; Region: COG2155 580047000002 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 580047000003 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 580047000004 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 580047000005 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) [Translation, ribosomal structure and biogenesis]; Region: GatB; COG0064 580047000006 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 580047000007 GatB domain; Region: GatB_Yqey; pfam02637 580047000008 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 580047000009 ribonuclease HIII; Region: rnhC; TIGR00716 580047000010 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 580047000011 RNA/DNA hybrid binding site [nucleotide binding]; other site 580047000012 active site 580047000013 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 580047000014 Helix-turn-helix domain; Region: HTH_25; pfam13413 580047000015 lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK05906 580047000016 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 580047000017 putative acyl-acceptor binding pocket; other site 580047000018 Uncharacterized conserved protein [Function unknown]; Region: COG1624 580047000019 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 580047000020 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 580047000021 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 580047000022 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 580047000023 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 580047000024 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 580047000025 putative active site [active] 580047000026 PhoH-like protein; Region: PhoH; pfam02562 580047000027 Bacterial SH3 domain homologues; Region: SH3b; smart00287 580047000028 Bacterial SH3 domain homologues; Region: SH3b; smart00287 580047000029 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 580047000030 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 580047000031 HIGH motif; other site 580047000032 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 580047000033 active site 580047000034 KMSKS motif; other site 580047000035 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 580047000036 tRNA binding surface [nucleotide binding]; other site 580047000037 anticodon binding site; other site 580047000038 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 580047000039 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 580047000040 Catalytic site [active] 580047000041 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 580047000042 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 580047000043 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 580047000044 peptide chain release factor 1; Validated; Region: prfA; PRK00591 580047000045 PCRF domain; Region: PCRF; pfam03462 580047000046 RF-1 domain; Region: RF-1; pfam00472 580047000047 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 580047000048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 580047000049 S-adenosylmethionine binding site [chemical binding]; other site 580047000050 signal recognition particle protein; Provisional; Region: PRK10867 580047000051 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 580047000052 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 580047000053 P loop; other site 580047000054 GTP binding site [chemical binding]; other site 580047000055 Signal peptide binding domain; Region: SRP_SPB; pfam02978 580047000056 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14522 580047000057 tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Reviewed; Region: trmD; PRK01037 580047000058 tRNA-(guanine-N1)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmD; COG0336 580047000059 ribosomal protein L19, bacterial type; Region: rplS_bact; TIGR01024 580047000060 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 580047000061 RNA/DNA hybrid binding site [nucleotide binding]; other site 580047000062 active site 580047000063 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 580047000064 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 580047000065 catalytic site [active] 580047000066 G-X2-G-X-G-K; other site 580047000067 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 580047000068 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 580047000069 active site 580047000070 HIGH motif; other site 580047000071 KMSKS motif; other site 580047000072 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 580047000073 tRNA binding surface [nucleotide binding]; other site 580047000074 anticodon binding site; other site 580047000075 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 580047000076 AAA domain; Region: AAA_30; pfam13604 580047000077 Family description; Region: UvrD_C_2; pfam13538 580047000078 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 580047000079 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 580047000080 conserved cys residue [active] 580047000081 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 580047000082 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 580047000083 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 580047000084 trimer interface [polypeptide binding]; other site 580047000085 active site 580047000086 Holliday junction resolvasome, helicase subunit [DNA replication, recombination, and repair]; Region: RuvB; COG2255 580047000087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 580047000088 Walker A motif; other site 580047000089 ATP binding site [chemical binding]; other site 580047000090 Walker B motif; other site 580047000091 arginine finger; other site 580047000092 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 580047000093 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 580047000094 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 580047000095 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 580047000096 active site 580047000097 catalytic site [active] 580047000098 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 580047000099 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 580047000100 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 580047000101 dimer interface [polypeptide binding]; other site 580047000102 ssDNA binding site [nucleotide binding]; other site 580047000103 tetramer (dimer of dimers) interface [polypeptide binding]; other site 580047000104 multifunctional aminopeptidase A; Provisional; Region: PRK00913 580047000105 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 580047000106 interface (dimer of trimers) [polypeptide binding]; other site 580047000107 Substrate-binding/catalytic site; other site 580047000108 Zn-binding sites [ion binding]; other site 580047000109 hypothetical protein; Provisional; Region: PRK05907 580047000110 Predicted methyltransferases [General function prediction only]; Region: COG0313 580047000111 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 580047000112 putative SAM binding site [chemical binding]; other site 580047000113 homodimer interface [polypeptide binding]; other site 580047000114 coproporphyrinogen III oxidase; Provisional; Region: PRK06294 580047000115 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 580047000116 FeS/SAM binding site; other site 580047000117 HemN C-terminal domain; Region: HemN_C; pfam06969 580047000118 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; Region: SucA; COG0567 580047000119 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 580047000120 TPP-binding site [chemical binding]; other site 580047000121 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 580047000122 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 580047000123 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 580047000124 E3 interaction surface; other site 580047000125 lipoyl attachment site [posttranslational modification]; other site 580047000126 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 580047000127 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 580047000128 uncharacterized protein, YfiH family; Region: TIGR00726 580047000129 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 580047000130 1-hydroxy-2-methyl-2-(e)-butenyl 4-diphosphate synthase [Lipid metabolism]; Region: gcpE; COG0821 580047000132 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 580047000133 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 580047000134 catalytic loop [active] 580047000135 iron binding site [ion binding]; other site 580047000136 type III secretion system protein; Validated; Region: PRK05910 580047000137 FHIPEP family; Region: FHIPEP; pfam00771 580047000138 RNA polymerase sigma factor sigma-28; Reviewed; Region: PRK05911 580047000139 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 580047000140 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 580047000141 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 580047000142 DNA binding residues [nucleotide binding] 580047000143 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 580047000144 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 580047000145 active site 580047000146 HIGH motif; other site 580047000147 dimer interface [polypeptide binding]; other site 580047000148 KMSKS motif; other site 580047000149 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 580047000150 RNA binding surface [nucleotide binding]; other site 580047000151 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 580047000152 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 580047000153 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 580047000154 GTP-binding protein LepA; Provisional; Region: PRK05433 580047000155 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 580047000156 G1 box; other site 580047000157 putative GEF interaction site [polypeptide binding]; other site 580047000158 GTP/Mg2+ binding site [chemical binding]; other site 580047000159 Switch I region; other site 580047000160 G2 box; other site 580047000161 G3 box; other site 580047000162 Switch II region; other site 580047000163 G4 box; other site 580047000164 G5 box; other site 580047000165 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 580047000166 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 580047000167 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 580047000168 ADP/ATP carrier protein family; Region: AAA; TIGR00769 580047000169 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 580047000170 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 580047000171 intersubunit interface [polypeptide binding]; other site 580047000172 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 580047000173 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 580047000174 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 580047000175 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 580047000176 ABC-ATPase subunit interface; other site 580047000177 dimer interface [polypeptide binding]; other site 580047000178 putative PBP binding regions; other site 580047000179 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 580047000180 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 580047000181 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 580047000182 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 580047000183 ABC-ATPase subunit interface; other site 580047000184 dimer interface [polypeptide binding]; other site 580047000185 putative PBP binding regions; other site 580047000186 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 580047000187 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 580047000188 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 580047000189 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 580047000190 RIP metalloprotease RseP; Region: TIGR00054 580047000191 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 580047000192 active site 580047000193 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 580047000194 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 580047000195 putative substrate binding region [chemical binding]; other site 580047000196 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 580047000197 Putative serine esterase (DUF676); Region: DUF676; pfam05057 580047000198 recF protein; Region: recf; TIGR00611 580047000199 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580047000200 Walker A/P-loop; other site 580047000201 ATP binding site [chemical binding]; other site 580047000202 Q-loop/lid; other site 580047000203 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580047000204 ABC transporter signature motif; other site 580047000205 Walker B; other site 580047000206 DNA polymerase III subunit beta; Validated; Region: PRK05643 580047000207 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 580047000208 putative DNA binding surface [nucleotide binding]; other site 580047000209 dimer interface [polypeptide binding]; other site 580047000210 beta-clamp/clamp loader binding surface; other site 580047000211 beta-clamp/translesion DNA polymerase binding surface; other site 580047000212 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 580047000213 SmpB-tmRNA interface; other site 580047000214 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 580047000215 ApbE family; Region: ApbE; pfam02424 580047000216 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14181 580047000217 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 580047000218 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 580047000219 homodimer interface [polypeptide binding]; other site 580047000220 NADP binding site [chemical binding]; other site 580047000221 substrate binding site [chemical binding]; other site 580047000222 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 580047000223 PLD-like domain; Region: PLDc_2; pfam13091 580047000224 putative active site [active] 580047000225 catalytic site [active] 580047000226 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 580047000227 PLD-like domain; Region: PLDc_2; pfam13091 580047000228 putative active site [active] 580047000229 catalytic site [active] 580047000230 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 580047000231 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 580047000232 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 580047000233 4-alpha-glucanotransferase; Region: Glyco_hydro_77; pfam02446 580047000234 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 580047000235 HrpJ-like domain; Region: HrpJ; cl15454 580047000236 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 580047000237 FHIPEP family; Region: FHIPEP; pfam00771 580047000238 type III secretion system protein; Validated; Region: PRK06298 580047000239 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 580047000240 GTP-binding protein YchF; Reviewed; Region: PRK09601 580047000241 YchF GTPase; Region: YchF; cd01900 580047000242 G1 box; other site 580047000243 GTP/Mg2+ binding site [chemical binding]; other site 580047000244 Switch I region; other site 580047000245 G2 box; other site 580047000246 Switch II region; other site 580047000247 G3 box; other site 580047000248 G4 box; other site 580047000249 G5 box; other site 580047000250 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 580047000251 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 580047000252 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 580047000253 active site 580047000254 Riboflavin kinase; Region: Flavokinase; smart00904 580047000255 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00989 580047000256 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 580047000257 RNA binding site [nucleotide binding]; other site 580047000258 active site 580047000259 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 580047000260 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 580047000261 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 580047000262 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 580047000263 G1 box; other site 580047000264 putative GEF interaction site [polypeptide binding]; other site 580047000265 GTP/Mg2+ binding site [chemical binding]; other site 580047000266 Switch I region; other site 580047000267 G2 box; other site 580047000268 G3 box; other site 580047000269 Switch II region; other site 580047000270 G4 box; other site 580047000271 G5 box; other site 580047000272 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 580047000273 Translation-initiation factor 2; Region: IF-2; pfam11987 580047000274 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 580047000275 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 580047000276 NusA N-terminal domain; Region: NusA_N; pfam08529 580047000277 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 580047000278 RNA binding site [nucleotide binding]; other site 580047000279 homodimer interface [polypeptide binding]; other site 580047000280 NusA-like KH domain; Region: KH_5; pfam13184 580047000281 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 580047000282 G-X-X-G motif; other site 580047000283 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 580047000284 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 580047000285 RNA binding site [nucleotide binding]; other site 580047000286 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 580047000287 RNA binding site [nucleotide binding]; other site 580047000288 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 580047000289 RNA binding site [nucleotide binding]; other site 580047000290 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 580047000291 RNA binding site [nucleotide binding]; other site 580047000292 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 580047000293 RNA binding site [nucleotide binding]; other site 580047000294 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 580047000295 RNA binding site [nucleotide binding]; other site 580047000296 domain interface; other site 580047000297 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 580047000298 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 580047000299 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 580047000300 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 580047000301 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 580047000302 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 580047000303 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 580047000304 active site 580047000305 motif I; other site 580047000306 motif II; other site 580047000307 enoyl-[acyl-carrier-protein] reductase; Region: PLN02730 580047000308 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 580047000309 NAD binding site [chemical binding]; other site 580047000310 homotetramer interface [polypeptide binding]; other site 580047000311 homodimer interface [polypeptide binding]; other site 580047000312 substrate binding site [chemical binding]; other site 580047000313 active site 580047000315 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 580047000316 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 580047000317 RNA binding surface [nucleotide binding]; other site 580047000318 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 580047000319 active site 580047000320 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 580047000321 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 580047000322 minor groove reading motif; other site 580047000323 helix-hairpin-helix signature motif; other site 580047000324 substrate binding pocket [chemical binding]; other site 580047000325 active site 580047000326 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 580047000327 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 580047000328 DNA binding and oxoG recognition site [nucleotide binding] 580047000329 Uncharacterized conserved protein [Function unknown]; Region: COG0327 580047000330 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 580047000331 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 580047000332 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 580047000333 ring oligomerisation interface [polypeptide binding]; other site 580047000334 ATP/Mg binding site [chemical binding]; other site 580047000335 stacking interactions; other site 580047000336 hinge regions; other site 580047000337 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 580047000338 oligomerisation interface [polypeptide binding]; other site 580047000339 mobile loop; other site 580047000340 roof hairpin; other site 580047000341 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 580047000342 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 580047000343 active site 580047000344 Zn binding site [ion binding]; other site 580047000345 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 580047000346 Clp amino terminal domain; Region: Clp_N; pfam02861 580047000347 Clp amino terminal domain; Region: Clp_N; pfam02861 580047000348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 580047000349 Walker A motif; other site 580047000350 ATP binding site [chemical binding]; other site 580047000351 Walker B motif; other site 580047000352 arginine finger; other site 580047000353 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 580047000354 Walker A motif; other site 580047000355 ATP binding site [chemical binding]; other site 580047000356 Walker B motif; other site 580047000357 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 580047000358 Uncharacterized conserved protein [Function unknown]; Region: COG2912 580047000359 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 580047000360 IncA protein; Region: IncA; pfam04156 580047000362 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 580047000363 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 580047000364 substrate binding site [chemical binding]; other site 580047000365 hexamer interface [polypeptide binding]; other site 580047000366 metal binding site [ion binding]; metal-binding site 580047000367 elongation factor P; Provisional; Region: PRK12426 580047000368 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 580047000369 RNA binding site [nucleotide binding]; other site 580047000370 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 580047000371 RNA binding site [nucleotide binding]; other site 580047000372 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 580047000373 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 580047000374 carboxyltransferase (CT) interaction site; other site 580047000375 biotinylation site [posttranslational modification]; other site 580047000376 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 580047000377 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 580047000378 ATP-grasp domain; Region: ATP-grasp_4; cl17255 580047000379 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 580047000380 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 580047000381 23S rRNA interface [nucleotide binding]; other site 580047000382 L3 interface [polypeptide binding]; other site 580047000383 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 580047000384 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 580047000385 NlpC/P60 family; Region: NLPC_P60; cl17555 580047000386 adenylate kinase; Reviewed; Region: adk; PRK00279 580047000387 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 580047000388 AMP-binding site [chemical binding]; other site 580047000389 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 580047000390 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 580047000391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580047000392 dimer interface [polypeptide binding]; other site 580047000393 conserved gate region; other site 580047000394 putative PBP binding loops; other site 580047000395 ABC-ATPase subunit interface; other site 580047000396 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 580047000397 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580047000398 Walker A/P-loop; other site 580047000399 ATP binding site [chemical binding]; other site 580047000400 Q-loop/lid; other site 580047000401 ABC transporter signature motif; other site 580047000402 Walker B; other site 580047000403 D-loop; other site 580047000404 H-loop/switch region; other site 580047000405 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 580047000406 Methyltransferase domain; Region: Methyltransf_23; pfam13489 580047000407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 580047000408 S-adenosylmethionine binding site [chemical binding]; other site 580047000410 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 580047000411 Serine hydrolase (FSH1); Region: FSH1; pfam03959 580047000412 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 580047000413 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 580047000414 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 580047000415 active site 580047000416 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 580047000417 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 580047000418 conserved hypothetical integral membrane protein; Region: TIGR00697 580047000419 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 580047000420 SEC-C motif; Region: SEC-C; pfam02810 580047000421 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 580047000422 Catalytic domain of Protein Kinases; Region: PKc; cd00180 580047000423 active site 580047000424 ATP binding site [chemical binding]; other site 580047000425 substrate binding site [chemical binding]; other site 580047000426 activation loop (A-loop); other site 580047000427 Uncharacterized conserved protein [Function unknown]; Region: COG1262 580047000428 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 580047000429 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 580047000430 DNA ligase, NAD-dependent; Region: dnlj; TIGR00575 580047000431 nucleotide binding pocket [chemical binding]; other site 580047000432 K-X-D-G motif; other site 580047000433 catalytic site [active] 580047000434 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 580047000435 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 580047000436 Helix-hairpin-helix motif; Region: HHH; pfam00633 580047000437 helix-hairpin-helix signature motif; other site 580047000438 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 580047000439 Dimer interface [polypeptide binding]; other site 580047000440 BRCT sequence motif; other site 580047000441 hypothetical protein; Provisional; Region: PRK06184 580047000442 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 580047000443 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 580047000444 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 580047000445 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 580047000446 FtsX-like permease family; Region: FtsX; pfam02687 580047000447 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 580047000448 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 580047000449 Walker A/P-loop; other site 580047000450 ATP binding site [chemical binding]; other site 580047000451 Q-loop/lid; other site 580047000452 ABC transporter signature motif; other site 580047000453 Walker B; other site 580047000454 D-loop; other site 580047000455 H-loop/switch region; other site 580047000456 membrane-attack complex / perforin; Region: MACPF; smart00457 580047000457 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases; Region: MIR; smart00472 580047000458 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 580047000459 PLD-like domain; Region: PLDc_2; pfam13091 580047000460 putative active site [active] 580047000461 catalytic site [active] 580047000462 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 580047000463 PLD-like domain; Region: PLDc_2; pfam13091 580047000464 putative active site [active] 580047000465 catalytic site [active] 580047000466 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 580047000467 PLD-like domain; Region: PLDc_2; pfam13091 580047000468 putative active site [active] 580047000469 catalytic site [active] 580047000470 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 580047000471 PLD-like domain; Region: PLDc_2; pfam13091 580047000472 putative active site [active] 580047000473 catalytic site [active] 580047000476 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 580047000477 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 580047000478 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 580047000479 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 580047000480 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 580047000481 trp operon repressor, proteobacterial; Region: TrpR; TIGR01321 580047000482 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 580047000483 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 580047000484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 580047000485 catalytic residue [active] 580047000488 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 580047000489 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 580047000490 peptide binding site [polypeptide binding]; other site 580047000491 putative disulfide oxidoreductase; Provisional; Region: PRK00611 580047000492 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 580047000493 Thioredoxin; Region: Thioredoxin_4; cl17273 580047000494 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 580047000495 putative active site [active] 580047000496 redox center [active] 580047000497 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 580047000498 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580047000499 Walker A/P-loop; other site 580047000500 ATP binding site [chemical binding]; other site 580047000501 Q-loop/lid; other site 580047000502 ABC transporter signature motif; other site 580047000503 Walker B; other site 580047000504 D-loop; other site 580047000505 H-loop/switch region; other site 580047000506 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 580047000507 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 580047000508 Ligand binding site; other site 580047000509 oligomer interface; other site 580047000510 CTP synthetase; Validated; Region: pyrG; PRK05380 580047000511 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 580047000512 Catalytic site [active] 580047000513 active site 580047000514 UTP binding site [chemical binding]; other site 580047000515 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 580047000516 active site 580047000517 putative oxyanion hole; other site 580047000518 catalytic triad [active] 580047000519 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 580047000520 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 580047000521 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 580047000522 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 580047000523 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 580047000524 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 580047000525 putative active site [active] 580047000526 DNA polymerase III subunit delta'; Validated; Region: PRK05917 580047000527 DNA polymerase III subunit delta'; Validated; Region: PRK08485 580047000528 thymidylate kinase; Validated; Region: tmk; PRK00698 580047000529 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 580047000530 TMP-binding site; other site 580047000531 ATP-binding site [chemical binding]; other site 580047000532 DNA gyrase, A subunit; Region: gyrA; TIGR01063 580047000533 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 580047000534 CAP-like domain; other site 580047000535 active site 580047000536 primary dimer interface [polypeptide binding]; other site 580047000537 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 580047000538 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 580047000539 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 580047000540 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 580047000541 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 580047000542 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 580047000543 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 580047000544 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 580047000545 ATP binding site [chemical binding]; other site 580047000546 Mg2+ binding site [ion binding]; other site 580047000547 G-X-G motif; other site 580047000548 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 580047000549 anchoring element; other site 580047000550 dimer interface [polypeptide binding]; other site 580047000551 ATP binding site [chemical binding]; other site 580047000552 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 580047000553 active site 580047000554 putative metal-binding site [ion binding]; other site 580047000555 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 580047000556 Protein of unknown function (DUF721); Region: DUF721; pfam05258 580047000557 carries characteristic twin membrane spanning domains 580047000558 queuine tRNA-ribosyltransferase; Provisional; Region: PRK01008 580047000559 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 580047000560 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 580047000561 MgtE intracellular N domain; Region: MgtE_N; pfam03448 580047000562 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 580047000563 Divalent cation transporter; Region: MgtE; pfam01769 580047000564 Metal-dependent proteases with possible chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: QRI7; COG0533 580047000565 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 580047000566 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 580047000567 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 580047000568 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 580047000569 peptide binding site [polypeptide binding]; other site 580047000570 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 580047000571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580047000572 dimer interface [polypeptide binding]; other site 580047000573 conserved gate region; other site 580047000574 putative PBP binding loops; other site 580047000575 ABC-ATPase subunit interface; other site 580047000576 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 580047000577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580047000578 dimer interface [polypeptide binding]; other site 580047000579 conserved gate region; other site 580047000580 putative PBP binding loops; other site 580047000581 ABC-ATPase subunit interface; other site 580047000582 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 580047000583 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 580047000584 Walker A/P-loop; other site 580047000585 ATP binding site [chemical binding]; other site 580047000586 Q-loop/lid; other site 580047000587 ABC transporter signature motif; other site 580047000588 Walker B; other site 580047000589 D-loop; other site 580047000590 H-loop/switch region; other site 580047000591 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 580047000592 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 580047000593 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 580047000594 Walker A/P-loop; other site 580047000595 ATP binding site [chemical binding]; other site 580047000596 Q-loop/lid; other site 580047000597 ABC transporter signature motif; other site 580047000598 Walker B; other site 580047000599 D-loop; other site 580047000600 H-loop/switch region; other site 580047000601 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 580047000602 Protein of unknown function (DUF1186); Region: DUF1186; pfam06685 580047000603 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 580047000604 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 580047000605 transmembrane helices; other site 580047000606 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 580047000607 active site 580047000608 ADP/pyrophosphate binding site [chemical binding]; other site 580047000609 dimerization interface [polypeptide binding]; other site 580047000610 allosteric effector site; other site 580047000611 fructose-1,6-bisphosphate binding site; other site 580047000612 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 580047000613 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 580047000614 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 580047000615 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 580047000616 active site 580047000617 ADP/pyrophosphate binding site [chemical binding]; other site 580047000618 dimerization interface [polypeptide binding]; other site 580047000619 allosteric effector site; other site 580047000620 fructose-1,6-bisphosphate binding site; other site 580047000621 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 580047000622 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 580047000623 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 580047000624 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 580047000625 HIGH motif; other site 580047000626 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 580047000627 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 580047000628 active site 580047000629 KMSKS motif; other site 580047000630 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 580047000631 tRNA binding surface [nucleotide binding]; other site 580047000632 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00615 580047000633 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 580047000634 inhibitor-cofactor binding pocket; inhibition site 580047000635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 580047000636 catalytic residue [active] 580047000637 Putative transcriptional regulator [Transcription]; Region: COG1678 580047000638 Uncharacterized conserved protein [Function unknown]; Region: COG1259 580047000639 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 580047000640 tetramer (dimer of dimers) interface [polypeptide binding]; other site 580047000641 active site 580047000642 dimer interface [polypeptide binding]; other site 580047000643 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 580047000644 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 580047000645 putative active site; other site 580047000646 catalytic residue [active] 580047000647 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 580047000648 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 580047000649 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 580047000650 Ligand Binding Site [chemical binding]; other site 580047000651 Predicted acid phosphatase [General function prediction only]; Region: SurE; COG0496 580047000652 prenyltransferase; Reviewed; Region: ubiA; PRK12876 580047000653 UbiA prenyltransferase family; Region: UbiA; pfam01040 580047000654 aromatic acid decarboxylase; Validated; Region: PRK05920 580047000655 Flavoprotein; Region: Flavoprotein; pfam02441 580047000656 Uncharacterized conserved protein [Function unknown]; Region: COG1284 580047000657 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 580047000658 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 580047000659 IncA protein; Region: IncA; pfam04156 580047000660 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 580047000661 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 580047000662 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 580047000663 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 580047000664 Na2 binding site [ion binding]; other site 580047000665 putative substrate binding site 1 [chemical binding]; other site 580047000666 Na binding site 1 [ion binding]; other site 580047000667 putative substrate binding site 2 [chemical binding]; other site 580047000668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 580047000669 putative substrate translocation pore; other site 580047000670 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 580047000671 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 580047000672 ligand binding site [chemical binding]; other site 580047000673 flexible hinge region; other site 580047000674 acyl carrier protein; Provisional; Region: acpP; PRK00982 580047000675 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 580047000676 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 580047000677 NAD(P) binding site [chemical binding]; other site 580047000678 homotetramer interface [polypeptide binding]; other site 580047000679 homodimer interface [polypeptide binding]; other site 580047000680 active site 580047000681 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 580047000682 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 580047000683 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 580047000684 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 580047000685 dimer interface [polypeptide binding]; other site 580047000686 active site 580047000687 CoA binding pocket [chemical binding]; other site 580047000688 recombination protein RecR; Region: recR; TIGR00615 580047000689 RecR protein; Region: RecR; pfam02132 580047000690 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 580047000691 putative active site [active] 580047000692 putative metal-binding site [ion binding]; other site 580047000693 tetramer interface [polypeptide binding]; other site 580047000694 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 580047000695 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 580047000696 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 580047000697 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 580047000698 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 580047000699 Surface antigen; Region: Bac_surface_Ag; pfam01103 580047000700 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 580047000701 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 580047000702 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 580047000703 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 580047000704 trimer interface [polypeptide binding]; other site 580047000705 active site 580047000706 UDP-GlcNAc binding site [chemical binding]; other site 580047000707 lipid binding site [chemical binding]; lipid-binding site 580047000708 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 580047000709 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 580047000710 tetramer interface [polypeptide binding]; other site 580047000711 TPP-binding site [chemical binding]; other site 580047000712 heterodimer interface [polypeptide binding]; other site 580047000713 phosphorylation loop region [posttranslational modification] 580047000714 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 580047000715 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 580047000716 alpha subunit interface [polypeptide binding]; other site 580047000717 TPP binding site [chemical binding]; other site 580047000718 heterodimer interface [polypeptide binding]; other site 580047000719 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 580047000720 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 580047000721 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 580047000722 E3 interaction surface; other site 580047000723 lipoyl attachment site [posttranslational modification]; other site 580047000724 e3 binding domain; Region: E3_binding; pfam02817 580047000725 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 580047000726 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 580047000727 homodimer interface [polypeptide binding]; other site 580047000728 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 580047000729 active site pocket [active] 580047000730 chromosomal replication initiation protein; Provisional; Region: PRK12422 580047000731 DnaA N-terminal domain; Region: DnaA_N; pfam11638 580047000732 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 580047000733 Walker A motif; other site 580047000734 ATP binding site [chemical binding]; other site 580047000735 Walker B motif; other site 580047000736 arginine finger; other site 580047000737 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 580047000738 DnaA box-binding interface [nucleotide binding]; other site 580047000739 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001 580047000740 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 580047000741 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 580047000742 CAAX protease self-immunity; Region: Abi; pfam02517 580047000743 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 580047000744 homodimer interface [polypeptide binding]; other site 580047000745 metal binding site [ion binding]; metal-binding site 580047000746 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 580047000747 Domain of unknown function DUF21; Region: DUF21; pfam01595 580047000748 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 580047000749 Transporter associated domain; Region: CorC_HlyC; smart01091 580047000750 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 580047000751 Domain of unknown function DUF21; Region: DUF21; pfam01595 580047000752 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 580047000753 Transporter associated domain; Region: CorC_HlyC; smart01091 580047000754 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 580047000755 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 580047000756 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 580047000757 catalytic residue [active] 580047000758 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 580047000759 Protein phosphatase 2C; Region: PP2C; pfam00481 580047000760 active site 580047000761 Uncharacterized conserved protein [Function unknown]; Region: COG5465 580047000762 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 580047000763 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 580047000764 active site 580047000765 catalytic site [active] 580047000766 substrate binding site [chemical binding]; other site 580047000767 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 580047000768 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 580047000769 nucleosidase; Provisional; Region: PRK05634 580047000770 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 580047000771 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 580047000772 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580047000773 Walker A/P-loop; other site 580047000774 ATP binding site [chemical binding]; other site 580047000775 Q-loop/lid; other site 580047000776 ABC transporter signature motif; other site 580047000777 Walker B; other site 580047000778 D-loop; other site 580047000779 H-loop/switch region; other site 580047000780 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 580047000781 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 580047000782 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 580047000783 IHF - DNA interface [nucleotide binding]; other site 580047000784 IHF dimer interface [polypeptide binding]; other site 580047000785 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 580047000786 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 580047000787 active site 580047000788 metal binding site [ion binding]; metal-binding site 580047000789 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 580047000790 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 580047000791 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 580047000792 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 580047000793 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 580047000794 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 580047000795 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 580047000796 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 580047000797 MraW methylase family; Region: Methyltransf_5; pfam01795 580047000798 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 580047000799 TPR motif; other site 580047000800 binding surface 580047000801 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 580047000802 DnaA N-terminal domain; Region: DnaA_N; pfam11638 580047000803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 580047000804 Walker A motif; other site 580047000805 ATP binding site [chemical binding]; other site 580047000806 Walker B motif; other site 580047000807 arginine finger; other site 580047000808 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 580047000809 DnaA box-binding interface [nucleotide binding]; other site 580047000810 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 580047000811 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 580047000812 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK01024 580047000813 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 580047000814 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 580047000815 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD [Energy production and conversion]; Region: NqrD; COG1347 580047000816 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK01061 580047000817 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 580047000818 lipoyl attachment site [posttranslational modification]; other site 580047000819 Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076 580047000820 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 580047000821 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 580047000822 putative active site [active] 580047000823 catalytic site [active] 580047000824 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 580047000825 putative active site [active] 580047000826 catalytic site [active] 580047000827 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 580047000828 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 580047000829 Clp amino terminal domain; Region: Clp_N; pfam02861 580047000830 Clp amino terminal domain; Region: Clp_N; pfam02861 580047000831 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 580047000832 Walker A motif; other site 580047000833 ATP binding site [chemical binding]; other site 580047000834 Walker B motif; other site 580047000835 arginine finger; other site 580047000836 UvrB/uvrC motif; Region: UVR; pfam02151 580047000837 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 580047000838 Walker A motif; other site 580047000839 ATP binding site [chemical binding]; other site 580047000840 Walker B motif; other site 580047000841 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 580047000842 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 580047000843 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 580047000844 Ligand Binding Site [chemical binding]; other site 580047000845 Helix-turn-helix domain; Region: HTH_17; pfam12728 580047000846 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 580047000847 active site 580047000848 phosphorylation site [posttranslational modification] 580047000849 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 580047000850 active site 580047000851 phosphorylation site [posttranslational modification] 580047000852 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 580047000853 trimer interface [polypeptide binding]; other site 580047000854 active site 580047000855 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 580047000856 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 580047000857 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 580047000858 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 580047000859 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 580047000860 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 580047000861 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 580047000862 active site 580047000863 substrate binding site [chemical binding]; other site 580047000864 metal binding site [ion binding]; metal-binding site 580047000865 ribonuclease III; Reviewed; Region: rnc; PRK00102 580047000866 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 580047000867 dimerization interface [polypeptide binding]; other site 580047000868 active site 580047000869 metal binding site [ion binding]; metal-binding site 580047000870 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 580047000871 dsRNA binding site [nucleotide binding]; other site 580047000872 DNA repair protein RadA; Provisional; Region: PRK11823 580047000873 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 580047000874 Walker A motif/ATP binding site; other site 580047000875 ATP binding site [chemical binding]; other site 580047000876 Walker B motif; other site 580047000877 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 580047000878 porphobilinogen deaminase; Provisional; Region: PRK01066 580047000879 Porphobilinogen deaminase, dipyromethane cofactor binding domain; Region: Porphobil_deam; pfam01379 580047000880 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 580047000881 Catalytic domain of Protein Kinases; Region: PKc; cd00180 580047000882 active site 580047000883 ATP binding site [chemical binding]; other site 580047000884 substrate binding site [chemical binding]; other site 580047000885 activation loop (A-loop); other site 580047000886 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 580047000887 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 580047000888 HIGH motif; other site 580047000889 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 580047000890 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 580047000891 active site 580047000892 KMSKS motif; other site 580047000893 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 580047000894 tRNA binding surface [nucleotide binding]; other site 580047000895 anticodon binding site; other site 580047000896 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 580047000897 V-type ATP synthase subunit K; Provisional; Region: PRK09621 580047000898 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 580047000899 V-type ATP synthase subunit I; Validated; Region: PRK05771 580047000900 Protein of unknown function (DUF1319); Region: DUF1319; pfam07028 580047000901 V-type ATP synthase subunit D; Provisional; Region: PRK02195 580047000902 V-type ATP synthase subunit B; Provisional; Region: PRK02118 580047000903 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 580047000904 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 580047000905 Walker A motif homologous position; other site 580047000906 Walker B motif; other site 580047000907 V-type ATP synthase subunit A; Provisional; Region: PRK04192 580047000908 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 580047000909 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 580047000910 Walker A motif/ATP binding site; other site 580047000911 Walker B motif; other site 580047000912 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 580047000913 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 580047000914 V-type ATP synthase subunit E; Provisional; Region: PRK01005 580047000915 V-type ATP synthase subunit E; Provisional; Region: PRK01558 580047000916 transaldolase-like protein; Provisional; Region: PTZ00411 580047000917 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 580047000918 active site 580047000919 dimer interface [polypeptide binding]; other site 580047000920 catalytic residue [active] 580047000921 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 580047000922 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 580047000923 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 580047000924 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 580047000925 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 580047000926 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 580047000927 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 580047000928 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 580047000929 DNA binding site [nucleotide binding] 580047000930 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 580047000931 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 580047000932 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 580047000933 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 580047000934 DNA-directed RNA polymerase, beta subunit; Region: rpoB; TIGR02013 580047000935 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 580047000936 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 580047000937 RPB12 interaction site [polypeptide binding]; other site 580047000938 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 580047000939 RPB3 interaction site [polypeptide binding]; other site 580047000940 RPB1 interaction site [polypeptide binding]; other site 580047000941 RPB11 interaction site [polypeptide binding]; other site 580047000942 RPB10 interaction site [polypeptide binding]; other site 580047000943 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 580047000944 L11 interface [polypeptide binding]; other site 580047000945 putative EF-Tu interaction site [polypeptide binding]; other site 580047000946 putative EF-G interaction site [polypeptide binding]; other site 580047000947 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 580047000948 23S rRNA interface [nucleotide binding]; other site 580047000949 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 580047000950 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 580047000951 mRNA/rRNA interface [nucleotide binding]; other site 580047000952 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 580047000953 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 580047000954 putative thiostrepton binding site; other site 580047000955 23S rRNA interface [nucleotide binding]; other site 580047000956 L7/L12 interface [polypeptide binding]; other site 580047000957 L25 interface [polypeptide binding]; other site 580047000958 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 580047000959 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 580047000960 putative homodimer interface [polypeptide binding]; other site 580047000961 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 580047000962 heterodimer interface [polypeptide binding]; other site 580047000963 homodimer interface [polypeptide binding]; other site 580047000964 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 580047000965 elongation factor Tu; Reviewed; Region: PRK12735 580047000966 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 580047000967 G1 box; other site 580047000968 GEF interaction site [polypeptide binding]; other site 580047000969 GTP/Mg2+ binding site [chemical binding]; other site 580047000970 Switch I region; other site 580047000971 G2 box; other site 580047000972 G3 box; other site 580047000973 Switch II region; other site 580047000974 G4 box; other site 580047000975 G5 box; other site 580047000976 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 580047000977 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 580047000978 Antibiotic Binding Site [chemical binding]; other site 580047000979 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 580047000980 rRNA binding site [nucleotide binding]; other site 580047000981 predicted 30S ribosome binding site; other site 580047000982 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 580047000984 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 580047000985 active site 580047000986 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 580047000987 triosephosphate isomerase; Provisional; Region: PRK14565 580047000988 substrate binding site [chemical binding]; other site 580047000989 dimer interface [polypeptide binding]; other site 580047000990 catalytic triad [active] 580047000991 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 580047000992 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 580047000993 generic binding surface II; other site 580047000994 generic binding surface I; other site 580047000995 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 580047000996 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 580047000997 1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292 580047000998 TPP-binding site [chemical binding]; other site 580047000999 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 580047001000 PYR/PP interface [polypeptide binding]; other site 580047001001 dimer interface [polypeptide binding]; other site 580047001002 TPP binding site [chemical binding]; other site 580047001003 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 580047001004 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 580047001005 pyruvate kinase; Region: pyruv_kin; TIGR01064 580047001006 domain interfaces; other site 580047001007 active site 580047001008 excinuclease ABC subunit A; Provisional; Region: PRK00635 580047001009 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 580047001010 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 580047001011 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 580047001012 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580047001013 Walker A/P-loop; other site 580047001014 ATP binding site [chemical binding]; other site 580047001015 Q-loop/lid; other site 580047001016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580047001017 ABC transporter signature motif; other site 580047001018 Walker B; other site 580047001019 D-loop; other site 580047001020 H-loop/switch region; other site 580047001021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580047001022 Walker A/P-loop; other site 580047001023 ATP binding site [chemical binding]; other site 580047001024 Q-loop/lid; other site 580047001025 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580047001026 Q-loop/lid; other site 580047001027 ABC transporter signature motif; other site 580047001028 Walker B; other site 580047001029 D-loop; other site 580047001030 H-loop/switch region; other site 580047001031 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305 580047001032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 580047001033 Walker A motif; other site 580047001034 ATP binding site [chemical binding]; other site 580047001035 Walker B motif; other site 580047001036 arginine finger; other site 580047001037 hypothetical protein; Validated; Region: PRK00153 580047001038 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 580047001039 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 580047001040 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 580047001041 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 580047001042 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 580047001043 dimerization domain swap beta strand [polypeptide binding]; other site 580047001044 regulatory protein interface [polypeptide binding]; other site 580047001045 active site 580047001046 regulatory phosphorylation site [posttranslational modification]; other site 580047001047 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 580047001048 Competence protein; Region: Competence; pfam03772 580047001049 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 580047001050 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 580047001051 tetramer interface [polypeptide binding]; other site 580047001052 TPP-binding site [chemical binding]; other site 580047001053 heterodimer interface [polypeptide binding]; other site 580047001054 phosphorylation loop region [posttranslational modification] 580047001055 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 580047001056 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 580047001057 alpha subunit interface [polypeptide binding]; other site 580047001058 TPP binding site [chemical binding]; other site 580047001059 heterodimer interface [polypeptide binding]; other site 580047001060 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 580047001061 chaperone protein DnaJ; Provisional; Region: PRK14284 580047001062 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 580047001063 HSP70 interaction site [polypeptide binding]; other site 580047001064 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 580047001065 Zn binding sites [ion binding]; other site 580047001066 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 580047001067 dimer interface [polypeptide binding]; other site 580047001068 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 580047001069 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 580047001070 Glycoprotease family; Region: Peptidase_M22; pfam00814 580047001071 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 580047001072 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 580047001073 Walker A motif; other site 580047001074 ATP binding site [chemical binding]; other site 580047001075 Walker B motif; other site 580047001076 arginine finger; other site 580047001077 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 580047001078 ribonuclease Z; Region: RNase_Z; TIGR02651 580047001079 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 580047001080 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 580047001081 active site 580047001082 Int/Topo IB signature motif; other site 580047001083 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 580047001084 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 580047001085 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 580047001086 ABC transporter; Region: ABC_tran_2; pfam12848 580047001087 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 580047001088 Maf-like protein; Region: Maf; pfam02545 580047001089 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 580047001090 active site 580047001091 dimer interface [polypeptide binding]; other site 580047001092 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 580047001093 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 580047001094 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 580047001095 active site 580047001096 catalytic residues [active] 580047001097 metal binding site [ion binding]; metal-binding site 580047001098 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 580047001099 dimethyladenosine transferase; Region: ksgA; TIGR00755 580047001100 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 580047001101 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 580047001102 catalytic residues [active] 580047001103 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 580047001104 dihydrodipicolinate synthase; Region: dapA; TIGR00674 580047001105 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 580047001106 inhibitor site; inhibition site 580047001107 active site 580047001108 dimer interface [polypeptide binding]; other site 580047001109 catalytic residue [active] 580047001110 aspartate kinase; Provisional; Region: PRK05925 580047001111 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 580047001112 putative catalytic residues [active] 580047001113 nucleotide binding site [chemical binding]; other site 580047001114 aspartate binding site [chemical binding]; other site 580047001115 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 580047001116 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 580047001117 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 580047001118 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 580047001119 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 580047001120 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 580047001121 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 580047001122 hinge; other site 580047001123 active site 580047001124 shikimate kinase; Provisional; Region: PRK00625 580047001125 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 580047001126 ADP binding site [chemical binding]; other site 580047001127 magnesium binding site [ion binding]; other site 580047001128 putative shikimate binding site; other site 580047001129 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 580047001130 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 580047001131 Tetramer interface [polypeptide binding]; other site 580047001132 active site 580047001133 FMN-binding site [chemical binding]; other site 580047001134 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 580047001135 active site 580047001136 dimer interface [polypeptide binding]; other site 580047001137 metal binding site [ion binding]; metal-binding site 580047001138 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein; Reviewed; Region: aroDE; PRK09310 580047001139 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 580047001140 active site 580047001141 catalytic residue [active] 580047001142 dimer interface [polypeptide binding]; other site 580047001143 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 580047001144 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 580047001145 shikimate binding site; other site 580047001146 NAD(P) binding site [chemical binding]; other site 580047001147 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 580047001148 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 580047001149 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) [Amino acid transport and metabolism]; Region: COG1945 580047001151 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 580047001152 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 580047001153 malate dehydrogenase; Provisional; Region: PRK05442 580047001154 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 580047001155 NAD(P) binding site [chemical binding]; other site 580047001156 dimer interface [polypeptide binding]; other site 580047001157 malate binding site [chemical binding]; other site 580047001158 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 580047001159 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 580047001160 active site 580047001161 dimer interface [polypeptide binding]; other site 580047001162 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 580047001163 dimer interface [polypeptide binding]; other site 580047001164 active site 580047001165 GTPases [General function prediction only]; Region: HflX; COG2262 580047001166 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 580047001167 HflX GTPase family; Region: HflX; cd01878 580047001168 G1 box; other site 580047001169 GTP/Mg2+ binding site [chemical binding]; other site 580047001170 Switch I region; other site 580047001171 G2 box; other site 580047001172 G3 box; other site 580047001173 Switch II region; other site 580047001174 G4 box; other site 580047001175 G5 box; other site 580047001176 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 580047001177 putative hydrolase; Provisional; Region: PRK02113 580047001178 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 580047001179 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 580047001180 substrate binding pocket [chemical binding]; other site 580047001181 membrane-bound complex binding site; other site 580047001182 hinge residues; other site 580047001183 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 580047001184 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 580047001185 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 580047001186 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 580047001187 nucleotide binding site/active site [active] 580047001188 Uncharacterized conserved protein related to MYG1 family [Function unknown]; Region: COG4286 580047001189 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 580047001190 hypothetical protein; Validated; Region: PRK00647 580047001191 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 580047001192 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 580047001193 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 580047001194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 580047001195 homodimer interface [polypeptide binding]; other site 580047001196 catalytic residue [active] 580047001197 ABC transporter substrate binding protein; Region: ABC_sub_bind; pfam04392 580047001198 prolyl-tRNA synthetase; Provisional; Region: PRK09194 580047001199 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 580047001200 dimer interface [polypeptide binding]; other site 580047001201 motif 1; other site 580047001202 active site 580047001203 motif 2; other site 580047001204 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 580047001205 putative deacylase active site [active] 580047001206 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 580047001207 active site 580047001208 motif 3; other site 580047001209 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 580047001210 anticodon binding site; other site 580047001211 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 580047001212 GrpE; Region: GrpE; pfam01025 580047001213 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 580047001214 dimer interface [polypeptide binding]; other site 580047001215 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 580047001216 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 580047001217 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 580047001218 nucleotide binding site [chemical binding]; other site 580047001219 NEF interaction site [polypeptide binding]; other site 580047001220 SBD interface [polypeptide binding]; other site 580047001221 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 580047001222 Exoribonuclease R [Transcription]; Region: VacB; COG0557 580047001223 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 580047001224 RNB domain; Region: RNB; pfam00773 580047001225 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 580047001226 Putative zinc ribbon domain; Region: DUF164; pfam02591 580047001227 KpsF/GutQ family protein; Region: kpsF; TIGR00393 580047001228 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 580047001229 putative active site [active] 580047001230 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 580047001231 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 580047001232 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 580047001233 E3 interaction surface; other site 580047001234 lipoyl attachment site [posttranslational modification]; other site 580047001235 e3 binding domain; Region: E3_binding; pfam02817 580047001236 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 580047001237 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 580047001238 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 580047001239 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 580047001240 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 580047001241 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 580047001242 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 580047001243 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 580047001244 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 580047001245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 580047001246 S-adenosylmethionine binding site [chemical binding]; other site 580047001247 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 580047001248 Lumazine binding domain; Region: Lum_binding; pfam00677 580047001249 Lumazine binding domain; Region: Lum_binding; pfam00677 580047001250 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 580047001251 ATP cone domain; Region: ATP-cone; pfam03477 580047001252 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 580047001253 Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597 580047001254 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 580047001255 amino acid carrier protein; Region: agcS; TIGR00835 580047001256 poly(A) polymerase; Region: pcnB; TIGR01942 580047001257 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 580047001258 active site 580047001259 NTP binding site [chemical binding]; other site 580047001260 metal binding triad [ion binding]; metal-binding site 580047001261 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 580047001262 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK01021 580047001263 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 580047001264 Predicted membrane protein [Function unknown]; Region: COG3952 580047001265 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 580047001266 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 580047001267 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 580047001268 Autotransporter beta-domain; Region: Autotransporter; pfam03797 580047001269 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 580047001270 Autotransporter beta-domain; Region: Autotransporter; pfam03797 580047001271 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 580047001272 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 580047001273 Autotransporter beta-domain; Region: Autotransporter; pfam03797 580047001274 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 580047001275 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 580047001276 intersubunit interface [polypeptide binding]; other site 580047001277 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580047001278 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 580047001279 Walker A/P-loop; other site 580047001280 ATP binding site [chemical binding]; other site 580047001281 Q-loop/lid; other site 580047001282 ABC transporter signature motif; other site 580047001283 Walker B; other site 580047001284 D-loop; other site 580047001285 H-loop/switch region; other site 580047001286 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 580047001287 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 580047001288 ABC-ATPase subunit interface; other site 580047001289 dimer interface [polypeptide binding]; other site 580047001290 putative PBP binding regions; other site 580047001291 GTPase CgtA; Reviewed; Region: obgE; PRK12299 580047001292 GTP1/OBG; Region: GTP1_OBG; pfam01018 580047001293 Obg GTPase; Region: Obg; cd01898 580047001294 G1 box; other site 580047001295 GTP/Mg2+ binding site [chemical binding]; other site 580047001296 Switch I region; other site 580047001297 G2 box; other site 580047001298 G3 box; other site 580047001299 Switch II region; other site 580047001300 G4 box; other site 580047001301 G5 box; other site 580047001302 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 580047001303 Ribosomal protein L21 [Translation, ribosomal structure and biogenesis]; Region: RplU; COG0261 580047001304 Uncharacterized conserved protein [Function unknown]; Region: COG2928 580047001305 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 580047001306 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 580047001307 FOG: CBS domain [General function prediction only]; Region: COG0517 580047001308 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 580047001309 Transporter associated domain; Region: CorC_HlyC; smart01091 580047001310 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 580047001311 anti sigma factor interaction site; other site 580047001312 regulatory phosphorylation site [posttranslational modification]; other site 580047001313 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 580047001314 hypothetical protein; Provisional; Region: PRK05926 580047001315 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 580047001316 FeS/SAM binding site; other site 580047001317 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 580047001318 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 580047001319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 580047001320 S-adenosylmethionine binding site [chemical binding]; other site 580047001321 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 580047001322 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 580047001323 diaminopimelate epimerase; Region: DapF; TIGR00652 580047001324 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 580047001325 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 580047001326 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 580047001327 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 580047001328 oligomer interface [polypeptide binding]; other site 580047001329 active site residues [active] 580047001330 serine hydroxymethyltransferase; Provisional; Region: PRK13580 580047001331 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 580047001332 dimer interface [polypeptide binding]; other site 580047001333 active site 580047001334 glycine-pyridoxal phosphate binding site [chemical binding]; other site 580047001335 folate binding site [chemical binding]; other site 580047001336 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 580047001337 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 580047001338 active site 580047001339 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 580047001340 homotrimer interaction site [polypeptide binding]; other site 580047001341 zinc binding site [ion binding]; other site 580047001342 CDP-binding sites; other site 580047001343 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 580047001344 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 580047001345 FAD binding pocket [chemical binding]; other site 580047001346 conserved FAD binding motif [chemical binding]; other site 580047001347 phosphate binding motif [ion binding]; other site 580047001348 beta-alpha-beta structure motif; other site 580047001349 NAD binding pocket [chemical binding]; other site 580047001350 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 580047001351 elongation factor G; Reviewed; Region: PRK12739 580047001352 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 580047001353 G1 box; other site 580047001354 putative GEF interaction site [polypeptide binding]; other site 580047001355 GTP/Mg2+ binding site [chemical binding]; other site 580047001356 Switch I region; other site 580047001357 G2 box; other site 580047001358 G3 box; other site 580047001359 Switch II region; other site 580047001360 G4 box; other site 580047001361 G5 box; other site 580047001362 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 580047001363 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 580047001364 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 580047001365 30S ribosomal protein S7; Validated; Region: PRK05302 580047001366 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 580047001367 S17 interaction site [polypeptide binding]; other site 580047001368 S8 interaction site; other site 580047001369 16S rRNA interaction site [nucleotide binding]; other site 580047001370 streptomycin interaction site [chemical binding]; other site 580047001371 23S rRNA interaction site [nucleotide binding]; other site 580047001372 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 580047001373 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 580047001374 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 580047001375 protein binding site [polypeptide binding]; other site 580047001376 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 580047001377 Catalytic dyad [active] 580047001378 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 580047001379 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA); Region: CRPA; pfam05745 580047001380 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 580047001381 Domain of unknown function DUF11; Region: DUF11; pfam01345 580047001382 Domain of unknown function DUF11; Region: DUF11; pfam01345 580047001383 Chlamydia cysteine-rich outer membrane protein 3; Region: Chlam_OMP3; pfam03503 580047001384 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 580047001385 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 580047001386 HIGH motif; other site 580047001387 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 580047001388 active site 580047001389 KMSKS motif; other site 580047001390 Helix-turn-helix domain; Region: HTH_17; pfam12728 580047001391 Helix-turn-helix domain; Region: HTH_17; cl17695 580047001392 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 580047001393 DHH family; Region: DHH; pfam01368 580047001394 DHHA1 domain; Region: DHHA1; pfam02272 580047001395 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK12911 580047001396 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 580047001397 Protein export membrane protein; Region: SecD_SecF; pfam02355 580047001398 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14840 580047001399 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 580047001400 catalytic residue [active] 580047001401 putative FPP diphosphate binding site; other site 580047001402 putative FPP binding hydrophobic cleft; other site 580047001403 dimer interface [polypeptide binding]; other site 580047001404 putative IPP diphosphate binding site; other site 580047001405 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 580047001406 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 580047001407 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 580047001408 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 580047001409 CMP-binding site; other site 580047001410 The sites determining sugar specificity; other site 580047001411 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 580047001412 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 580047001413 putative acyl-acceptor binding pocket; other site 580047001414 arginine-tRNA ligase; Region: PLN02286 580047001415 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 580047001416 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 580047001417 active site 580047001418 HIGH motif; other site 580047001419 KMSK motif region; other site 580047001420 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 580047001421 tRNA binding surface [nucleotide binding]; other site 580047001422 anticodon binding site; other site 580047001423 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 580047001424 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 580047001425 hinge; other site 580047001426 active site 580047001427 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 580047001428 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 580047001429 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 580047001430 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 580047001431 DNA-binding regulatory protein, YebC/PmpR family; Region: TIGR01033 580047001432 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 580047001433 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 580047001434 Coenzyme A binding pocket [chemical binding]; other site 580047001435 peptide chain release factor 2; Validated; Region: prfB; PRK00578 580047001436 PCRF domain; Region: PCRF; pfam03462 580047001437 RF-1 domain; Region: RF-1; pfam00472 580047001438 SWIB-domain-containing proteins implicated in chromatin remodeling [Chromatin structure and dynamics]; Region: COG5531 580047001439 SWI complex, BAF60b domains; Region: SWIB; smart00151 580047001440 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 580047001441 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 580047001442 putative active site [active] 580047001443 putative metal binding site [ion binding]; other site 580047001444 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 580047001445 substrate binding site; other site 580047001446 dimer interface; other site 580047001447 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 580047001448 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 580047001449 dimerization interface 3.5A [polypeptide binding]; other site 580047001450 active site 580047001451 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 580047001452 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 580047001453 active site 580047001454 motif I; other site 580047001455 motif II; other site 580047001456 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 580047001457 PAS domain; Region: PAS; smart00091 580047001458 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 580047001459 dimer interface [polypeptide binding]; other site 580047001460 phosphorylation site [posttranslational modification] 580047001461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 580047001462 ATP binding site [chemical binding]; other site 580047001463 Mg2+ binding site [ion binding]; other site 580047001464 G-X-G motif; other site 580047001465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 580047001466 Response regulator receiver domain; Region: Response_reg; pfam00072 580047001467 active site 580047001468 phosphorylation site [posttranslational modification] 580047001469 intermolecular recognition site; other site 580047001470 dimerization interface [polypeptide binding]; other site 580047001471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 580047001472 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 580047001473 Walker A motif; other site 580047001474 ATP binding site [chemical binding]; other site 580047001475 Walker B motif; other site 580047001476 arginine finger; other site 580047001477 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 580047001478 Recombination protein O N terminal; Region: RecO_N; pfam11967 580047001479 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 580047001480 Recombination protein O C terminal; Region: RecO_C; pfam02565 580047001481 Uncharacterized conserved protein [Function unknown]; Region: COG1723 580047001482 hypothetical protein; Provisional; Region: PRK14377 580047001483 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 580047001484 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 580047001485 putative tRNA-binding site [nucleotide binding]; other site 580047001486 B3/4 domain; Region: B3_4; pfam03483 580047001487 tRNA synthetase B5 domain; Region: B5; pfam03484 580047001488 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 580047001489 dimer interface [polypeptide binding]; other site 580047001490 motif 1; other site 580047001491 motif 3; other site 580047001492 motif 2; other site 580047001493 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 580047001494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 580047001495 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 580047001496 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 580047001497 DNA binding site [nucleotide binding] 580047001498 active site 580047001499 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 580047001500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580047001501 dimer interface [polypeptide binding]; other site 580047001502 conserved gate region; other site 580047001503 putative PBP binding loops; other site 580047001504 ABC-ATPase subunit interface; other site 580047001505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 580047001506 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 580047001507 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 580047001508 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 580047001509 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 580047001510 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 580047001511 putative active site [active] 580047001512 putative metal binding site [ion binding]; other site 580047001513 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 580047001514 binding surface 580047001515 TPR motif; other site 580047001516 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 580047001517 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 580047001518 C-terminal domain interface [polypeptide binding]; other site 580047001519 active site 580047001520 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 580047001521 active site 580047001522 N-terminal domain interface [polypeptide binding]; other site 580047001523 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 580047001524 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 580047001525 substrate binding pocket [chemical binding]; other site 580047001526 membrane-bound complex binding site; other site 580047001527 hinge residues; other site 580047001528 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 580047001529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 580047001530 S-adenosylmethionine binding site [chemical binding]; other site 580047001531 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 580047001532 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 580047001533 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 580047001534 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 580047001535 ligand binding site; other site 580047001536 oligomer interface; other site 580047001537 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 580047001538 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 580047001539 N-terminal domain interface [polypeptide binding]; other site 580047001540 sulfate 1 binding site; other site 580047001541 transcription termination factor Rho; Region: rho; TIGR00767 580047001542 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 580047001543 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 580047001544 RNA binding site [nucleotide binding]; other site 580047001545 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 580047001546 multimer interface [polypeptide binding]; other site 580047001547 Walker A motif; other site 580047001548 ATP binding site [chemical binding]; other site 580047001549 Walker B motif; other site 580047001550 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 580047001551 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 580047001552 CoA-binding site [chemical binding]; other site 580047001553 ATP-binding [chemical binding]; other site 580047001554 DNA polymerase I; Provisional; Region: PRK05755 580047001555 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 580047001556 active site 580047001557 metal binding site 1 [ion binding]; metal-binding site 580047001558 putative 5' ssDNA interaction site; other site 580047001559 metal binding site 3; metal-binding site 580047001560 metal binding site 2 [ion binding]; metal-binding site 580047001561 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 580047001562 putative DNA binding site [nucleotide binding]; other site 580047001563 putative metal binding site [ion binding]; other site 580047001564 3'-5' exonuclease; Region: 35EXOc; smart00474 580047001565 active site 580047001566 substrate binding site [chemical binding]; other site 580047001567 catalytic site [active] 580047001568 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 580047001569 active site 580047001570 DNA binding site [nucleotide binding] 580047001571 catalytic site [active] 580047001572 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 580047001573 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 580047001574 tandem repeat interface [polypeptide binding]; other site 580047001575 oligomer interface [polypeptide binding]; other site 580047001576 active site residues [active] 580047001577 TLC ATP/ADP transporter; Region: TLC; pfam03219 580047001578 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 580047001579 replicative DNA helicase; Provisional; Region: PRK06321 580047001580 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 580047001581 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 580047001582 Walker A motif; other site 580047001583 ATP binding site [chemical binding]; other site 580047001584 Walker B motif; other site 580047001585 DNA binding loops [nucleotide binding] 580047001586 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 580047001587 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 580047001588 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 580047001589 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 580047001590 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 580047001591 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 580047001592 active site 580047001593 multimer interface [polypeptide binding]; other site 580047001594 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 580047001595 RuvA N terminal domain; Region: RuvA_N; pfam01330 580047001596 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 580047001597 active site 580047001598 putative DNA-binding cleft [nucleotide binding]; other site 580047001599 dimer interface [polypeptide binding]; other site 580047001600 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 580047001601 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 580047001602 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 580047001603 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 580047001604 DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027 580047001605 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 580047001606 alphaNTD - beta interaction site [polypeptide binding]; other site 580047001607 alphaNTD homodimer interface [polypeptide binding]; other site 580047001608 alphaNTD - beta' interaction site [polypeptide binding]; other site 580047001609 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 580047001610 30S ribosomal protein S11; Validated; Region: PRK05309 580047001611 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 580047001612 30S ribosomal protein S13; Region: bact_S13; TIGR03631 580047001613 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 580047001614 SecY translocase; Region: SecY; pfam00344 580047001615 ribosomal protein L15, bacterial/organelle; Region: rplO_bact; TIGR01071 580047001616 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 580047001617 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 580047001618 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 580047001619 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 580047001620 5S rRNA interface [nucleotide binding]; other site 580047001621 23S rRNA interface [nucleotide binding]; other site 580047001622 L5 interface [polypeptide binding]; other site 580047001623 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 580047001624 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 580047001625 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 580047001626 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 580047001627 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 580047001628 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 580047001629 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 580047001630 Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Region: RplX; COG0198 580047001631 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 580047001632 RNA binding site [nucleotide binding]; other site 580047001633 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 580047001634 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 580047001635 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 580047001636 23S rRNA interface [nucleotide binding]; other site 580047001637 putative translocon interaction site; other site 580047001638 signal recognition particle (SRP54) interaction site; other site 580047001639 L23 interface [polypeptide binding]; other site 580047001640 trigger factor interaction site; other site 580047001641 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 580047001642 23S rRNA interface [nucleotide binding]; other site 580047001643 5S rRNA interface [nucleotide binding]; other site 580047001644 putative antibiotic binding site [chemical binding]; other site 580047001645 L25 interface [polypeptide binding]; other site 580047001646 L27 interface [polypeptide binding]; other site 580047001647 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 580047001648 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 580047001649 G-X-X-G motif; other site 580047001650 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 580047001651 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 580047001652 putative translocon binding site; other site 580047001653 protein-rRNA interface [nucleotide binding]; other site 580047001654 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 580047001655 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 580047001656 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 580047001657 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 580047001658 Ribosomal protein L23 [Translation, ribosomal structure and biogenesis]; Region: RplW; COG0089 580047001659 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 580047001660 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 580047001661 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 580047001662 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 580047001663 putative active site [active] 580047001664 substrate binding site [chemical binding]; other site 580047001665 putative cosubstrate binding site; other site 580047001666 catalytic site [active] 580047001667 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 580047001668 substrate binding site [chemical binding]; other site 580047001669 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 580047001670 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 580047001671 active site 580047001672 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 580047001673 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774 580047001674 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 580047001675 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 580047001676 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 580047001677 putative active site [active] 580047001678 catalytic triad [active] 580047001679 putative dimer interface [polypeptide binding]; other site 580047001680 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 580047001681 DNA polymerase III subunit epsilon; Validated; Region: PRK06310 580047001682 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 580047001683 active site 580047001684 catalytic site [active] 580047001685 substrate binding site [chemical binding]; other site 580047001686 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 580047001687 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 580047001688 Protein of unknown function (DUF2709); Region: DUF2709; pfam10915 580047001689 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 580047001690 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 580047001691 catalytic residues [active] 580047001692 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 580047001693 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 580047001694 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 580047001695 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 580047001696 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 580047001697 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 580047001698 dimer interface [polypeptide binding]; other site 580047001699 anticodon binding site; other site 580047001700 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 580047001701 homodimer interface [polypeptide binding]; other site 580047001702 motif 1; other site 580047001703 active site 580047001704 motif 2; other site 580047001705 GAD domain; Region: GAD; pfam02938 580047001706 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 580047001707 active site 580047001708 motif 3; other site 580047001709 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 580047001710 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 580047001711 dimer interface [polypeptide binding]; other site 580047001712 motif 1; other site 580047001713 active site 580047001714 motif 2; other site 580047001715 motif 3; other site 580047001716 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 580047001717 anticodon binding site; other site 580047001718 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 580047001719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 580047001720 putative substrate translocation pore; other site 580047001721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 580047001722 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 580047001723 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 580047001724 active site 580047001725 PHP Thumb interface [polypeptide binding]; other site 580047001726 metal binding site [ion binding]; metal-binding site 580047001727 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 580047001728 generic binding surface I; other site 580047001729 generic binding surface II; other site 580047001730 TPR repeat; Region: TPR_11; pfam13414 580047001731 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 580047001732 binding surface 580047001733 TPR motif; other site 580047001734 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 580047001735 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 580047001736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 580047001737 Mg2+ binding site [ion binding]; other site 580047001738 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 580047001739 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 580047001740 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 580047001741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 580047001742 S-adenosylmethionine binding site [chemical binding]; other site 580047001743 branched-chain amino acid uptake carrier; Region: livcs; TIGR00796 580047001744 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 580047001745 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 580047001746 ATP binding site [chemical binding]; other site 580047001747 putative Mg++ binding site [ion binding]; other site 580047001748 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 580047001749 nucleotide binding region [chemical binding]; other site 580047001750 ATP-binding site [chemical binding]; other site 580047001751 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 580047001752 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 580047001753 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 580047001754 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 580047001755 lipoate synthase; Region: lipA; TIGR00510 580047001756 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 580047001757 FeS/SAM binding site; other site 580047001758 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 580047001759 type III secretion system protein; Validated; Region: PRK06328 580047001760 Flagellar assembly protein FliH; Region: FliH; pfam02108 580047001761 type III secretion system protein; Reviewed; Region: PRK09617 580047001762 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 580047001763 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 580047001764 Protein of unknown function (DUF1494); Region: DUF1494; pfam07379 580047001765 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 580047001766 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 580047001767 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 580047001768 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 580047001769 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 580047001770 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 580047001771 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 580047001772 Walker A motif; other site 580047001773 ATP binding site [chemical binding]; other site 580047001774 Walker B motif; other site 580047001775 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 580047001776 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 580047001777 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 580047001778 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 580047001779 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 580047001780 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 580047001781 active site 580047001782 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 580047001783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 580047001784 ATP binding site [chemical binding]; other site 580047001785 Mg2+ binding site [ion binding]; other site 580047001786 G-X-G motif; other site 580047001787 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 580047001788 ATP binding site [chemical binding]; other site 580047001789 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 580047001790 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 580047001791 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 580047001792 binding surface 580047001793 TPR motif; other site 580047001794 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 580047001795 EamA-like transporter family; Region: EamA; pfam00892 580047001796 EamA-like transporter family; Region: EamA; pfam00892 580047001797 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 580047001798 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cd01616 580047001799 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 580047001800 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 580047001801 active site 580047001802 dimer interface [polypeptide binding]; other site 580047001803 motif 1; other site 580047001804 motif 2; other site 580047001805 motif 3; other site 580047001806 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 580047001807 anticodon binding site; other site 580047001808 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 580047001809 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 580047001810 Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677 580047001811 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 580047001812 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 580047001813 active site 580047001814 HIGH motif; other site 580047001815 dimer interface [polypeptide binding]; other site 580047001816 KMSKS motif; other site 580047001817 excinuclease ABC subunit B; Provisional; Region: PRK05298 580047001818 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 580047001819 ATP binding site [chemical binding]; other site 580047001820 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 580047001821 nucleotide binding region [chemical binding]; other site 580047001822 ATP-binding site [chemical binding]; other site 580047001823 Ultra-violet resistance protein B; Region: UvrB; pfam12344 580047001824 enolase; Provisional; Region: eno; PRK00077 580047001825 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 580047001826 dimer interface [polypeptide binding]; other site 580047001827 metal binding site [ion binding]; metal-binding site 580047001828 substrate binding pocket [chemical binding]; other site 580047001829 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 580047001830 HAMP domain; Region: HAMP; pfam00672 580047001831 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 580047001832 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 580047001833 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 580047001834 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 580047001836 this CDS carries multiple frameshift mutations. The sequence has been checked and is believed to be correct. 580047001837 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 580047001838 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 580047001839 active site 580047001840 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 580047001841 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 580047001842 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 580047001843 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 580047001844 DsbD alpha interface [polypeptide binding]; other site 580047001845 catalytic residues [active] 580047001846 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 580047001847 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 580047001848 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 580047001849 translocation protein TolB; Provisional; Region: tolB; PRK01029 580047001850 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 580047001851 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 580047001852 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 580047001853 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 580047001854 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 580047001855 ligand binding site [chemical binding]; other site 580047001856 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 580047001857 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 580047001858 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 580047001859 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 580047001860 dimer interface [polypeptide binding]; other site 580047001861 decamer (pentamer of dimers) interface [polypeptide binding]; other site 580047001862 catalytic triad [active] 580047001863 peroxidatic and resolving cysteines [active] 580047001864 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 580047001865 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 580047001866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 580047001867 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 580047001868 active site 580047001869 dimerization interface [polypeptide binding]; other site 580047001870 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 580047001871 ligand binding site [chemical binding]; other site 580047001872 active site 580047001873 UGI interface [polypeptide binding]; other site 580047001874 catalytic site [active] 580047001875 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 580047001876 Part of AAA domain; Region: AAA_19; pfam13245 580047001877 Family description; Region: UvrD_C_2; pfam13538 580047001878 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog [Transcription]; Region: RpoN; COG1508 580047001879 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 580047001880 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 580047001881 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 580047001882 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 580047001883 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 580047001884 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 580047001885 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 580047001886 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 580047001887 folate binding site [chemical binding]; other site 580047001888 NADP+ binding site [chemical binding]; other site 580047001889 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 580047001890 catalytic center binding site [active] 580047001891 ATP binding site [chemical binding]; other site 580047001892 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 580047001893 dihydropteroate synthase; Region: DHPS; TIGR01496 580047001894 substrate binding pocket [chemical binding]; other site 580047001895 dimer interface [polypeptide binding]; other site 580047001896 inhibitor binding site; inhibition site 580047001897 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 580047001898 homooctamer interface [polypeptide binding]; other site 580047001899 active site 580047001900 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 580047001901 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 580047001902 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 580047001903 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 580047001904 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 580047001905 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 580047001906 DNA binding residues [nucleotide binding] 580047001907 Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785 580047001908 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 580047001909 Effector from type III secretion system; Region: Effector_1; pfam04518 580047001910 Effector from type III secretion system; Region: Effector_1; pfam04518 580047001911 Effector from type III secretion system; Region: Effector_1; pfam04518 580047001912 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 580047001913 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 580047001914 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 580047001915 MviN-like protein; Region: MVIN; pfam03023 580047001916 endonuclease IV; Provisional; Region: PRK01060 580047001917 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 580047001918 AP (apurinic/apyrimidinic) site pocket; other site 580047001919 DNA interaction; other site 580047001920 Metal-binding active site; metal-binding site 580047001921 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 580047001922 ribosomal protein S4, bacterial/organelle type; Region: rpsD_bact; TIGR01017 580047001923 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 580047001924 RNA binding surface [nucleotide binding]; other site 580047001925 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 580047001926 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 580047001927 active site residue [active] 580047001928 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 580047001929 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 580047001930 substrate binding pocket [chemical binding]; other site 580047001931 chain length determination region; other site 580047001932 substrate-Mg2+ binding site; other site 580047001933 catalytic residues [active] 580047001934 aspartate-rich region 1; other site 580047001935 active site lid residues [active] 580047001936 aspartate-rich region 2; other site 580047001937 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 580047001938 putative trimer interface [polypeptide binding]; other site 580047001939 putative CoA binding site [chemical binding]; other site 580047001940 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 580047001941 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 580047001942 DNA binding site [nucleotide binding] 580047001943 Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351 580047001944 Thymidylate synthase complementing protein; Region: Thy1; cl03630 580047001945 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 580047001946 dimer interface [polypeptide binding]; other site 580047001947 active site 580047001948 aspartate-rich active site metal binding site; other site 580047001949 allosteric magnesium binding site [ion binding]; other site 580047001950 Schiff base residues; other site 580047001951 NADH:ubiquinone oxidoreductase, Na(+)-translocating, A subunit; Region: nqrA; TIGR01936 580047001952 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 580047001953 transcript cleavage factor/unknown domain fusion protein; Validated; Region: PRK06330 580047001954 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 580047001955 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 580047001956 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 580047001957 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 580047001958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 580047001959 homodimer interface [polypeptide binding]; other site 580047001960 catalytic residue [active] 580047001961 rod shape-determining protein MreC; Provisional; Region: PRK14872 580047001962 rod shape-determining protein MreC; Region: MreC; pfam04085 580047001963 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 580047001964 Part of AAA domain; Region: AAA_19; pfam13245 580047001965 Family description; Region: UvrD_C_2; pfam13538 580047001966 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 580047001967 Major Facilitator Superfamily; Region: MFS_1; pfam07690 580047001968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 580047001969 putative substrate translocation pore; other site 580047001970 DNA topoisomerase I/SWI domain fusion protein; Validated; Region: PRK06319 580047001971 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 580047001972 active site 580047001973 interdomain interaction site; other site 580047001974 putative metal-binding site [ion binding]; other site 580047001975 nucleotide binding site [chemical binding]; other site 580047001976 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 580047001977 domain I; other site 580047001978 DNA binding groove [nucleotide binding] 580047001979 phosphate binding site [ion binding]; other site 580047001980 domain II; other site 580047001981 domain III; other site 580047001982 nucleotide binding site [chemical binding]; other site 580047001983 catalytic site [active] 580047001984 domain IV; other site 580047001985 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 580047001986 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 580047001987 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 580047001988 SWI complex, BAF60b domains; Region: SWIB; smart00151 580047001989 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 580047001990 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 580047001991 FMN binding site [chemical binding]; other site 580047001992 active site 580047001993 catalytic residues [active] 580047001994 substrate binding site [chemical binding]; other site 580047001995 Predicted integral membrane protein [Function unknown]; Region: COG0762 580047001996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 580047001997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 580047001998 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 580047001999 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 580047002000 recombinase A; Provisional; Region: recA; PRK09354 580047002001 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 580047002002 hexamer interface [polypeptide binding]; other site 580047002003 Walker A motif; other site 580047002004 ATP binding site [chemical binding]; other site 580047002005 Walker B motif; other site 580047002006 Protein of unknown function (DUF1347); Region: DUF1347; pfam07079 580047002007 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 580047002008 AAA domain; Region: AAA_30; pfam13604 580047002009 Family description; Region: UvrD_C_2; pfam13538 580047002010 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 580047002011 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 580047002012 Walker A/P-loop; other site 580047002013 ATP binding site [chemical binding]; other site 580047002014 Q-loop/lid; other site 580047002015 ABC transporter signature motif; other site 580047002016 Walker B; other site 580047002017 D-loop; other site 580047002018 H-loop/switch region; other site 580047002019 Protein of unknown function (DUF1137); Region: DUF1137; pfam06587 580047002020 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 580047002021 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 580047002022 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 580047002023 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 580047002024 RNA binding surface [nucleotide binding]; other site 580047002025 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 580047002026 active site 580047002027 hypothetical protein; Provisional; Region: PRK01064 580047002028 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 580047002029 DNA topoisomerase IV subunit A; Provisional; Region: PRK09630 580047002030 DNA Topoisomerase IV; Region: TOP4c; smart00434 580047002031 CAP-like domain; other site 580047002032 active site 580047002033 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 580047002034 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 580047002035 ATP binding site [chemical binding]; other site 580047002036 Mg2+ binding site [ion binding]; other site 580047002037 G-X-G motif; other site 580047002038 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 580047002039 ATP binding site [chemical binding]; other site 580047002040 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 580047002041 active site 580047002042 putative metal-binding site [ion binding]; other site 580047002043 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 580047002044 glutamyl-tRNA reductase; Validated; Region: hemA; PRK00676 580047002045 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 580047002046 NAD(P) binding pocket [chemical binding]; other site 580047002047 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 580047002048 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 580047002049 phosphopeptide binding site; other site 580047002050 MARCKS family; Region: MARCKS; pfam02063 580047002051 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 580047002052 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 580047002053 phosphopeptide binding site; other site 580047002054 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 580047002055 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 580047002056 binding surface 580047002057 Tetratricopeptide repeat; Region: TPR_16; pfam13432 580047002058 TPR motif; other site 580047002059 type III secretion system ATPase; Provisional; Region: PRK06315 580047002060 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 580047002061 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 580047002062 Walker A motif/ATP binding site; other site 580047002063 Walker B motif; other site 580047002064 type III secretion system protein; Validated; Region: PRK05933 580047002065 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 580047002066 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 580047002067 Catalytic domain of Protein Kinases; Region: PKc; cd00180 580047002068 active site 580047002069 ATP binding site [chemical binding]; other site 580047002070 substrate binding site [chemical binding]; other site 580047002071 activation loop (A-loop); other site 580047002072 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 580047002073 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 580047002074 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 580047002075 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 580047002076 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 580047002077 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 580047002078 ADP binding site [chemical binding]; other site 580047002079 phosphagen binding site; other site 580047002080 substrate specificity loop; other site 580047002081 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 580047002082 UvrB/uvrC motif; Region: UVR; pfam02151 580047002083 ribosome recycling factor; Reviewed; Region: frr; PRK00083 580047002084 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 580047002085 hinge region; other site 580047002086 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 580047002087 putative nucleotide binding site [chemical binding]; other site 580047002088 uridine monophosphate binding site [chemical binding]; other site 580047002089 homohexameric interface [polypeptide binding]; other site 580047002090 Translation elongation factor Ts [Translation, ribosomal structure and biogenesis]; Region: Tsf; COG0264 580047002091 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 580047002092 Elongation factor TS; Region: EF_TS; pfam00889 580047002093 Elongation factor TS; Region: EF_TS; pfam00889 580047002094 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 580047002095 rRNA interaction site [nucleotide binding]; other site 580047002096 S8 interaction site; other site 580047002097 putative laminin-1 binding site; other site 580047002098 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 580047002099 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 580047002100 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 580047002101 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 580047002102 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 580047002103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 580047002104 TPR motif; other site 580047002105 Tetratricopeptide repeat; Region: TPR_16; pfam13432 580047002106 binding surface 580047002107 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 580047002108 binding surface 580047002109 TPR motif; other site 580047002110 TPR repeat; Region: TPR_11; pfam13414 580047002111 TPR repeat; Region: TPR_11; pfam13414 580047002112 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 580047002113 binding surface 580047002114 TPR motif; other site 580047002115 TPR repeat; Region: TPR_11; pfam13414 580047002116 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 580047002117 putative ABC transporter; Region: ycf24; CHL00085 580047002118 FeS assembly ATPase SufC; Region: sufC; TIGR01978 580047002119 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 580047002120 Walker A/P-loop; other site 580047002121 ATP binding site [chemical binding]; other site 580047002122 Q-loop/lid; other site 580047002123 ABC transporter signature motif; other site 580047002124 Walker B; other site 580047002125 D-loop; other site 580047002126 H-loop/switch region; other site 580047002127 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 580047002128 FeS assembly protein SufD; Region: sufD; TIGR01981 580047002129 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 580047002130 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 580047002131 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 580047002132 catalytic residue [active] 580047002133 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 580047002134 ParB-like nuclease domain; Region: ParBc; pfam02195 580047002135 KorB domain; Region: KorB; pfam08535 580047002136 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 580047002137 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 580047002138 Walker A/P-loop; other site 580047002139 ATP binding site [chemical binding]; other site 580047002140 Q-loop/lid; other site 580047002141 ABC transporter signature motif; other site 580047002142 Walker B; other site 580047002143 D-loop; other site 580047002144 H-loop/switch region; other site 580047002145 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 580047002146 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 580047002147 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 580047002148 Walker A/P-loop; other site 580047002149 ATP binding site [chemical binding]; other site 580047002150 Q-loop/lid; other site 580047002151 ABC transporter signature motif; other site 580047002152 Walker B; other site 580047002153 D-loop; other site 580047002154 H-loop/switch region; other site 580047002155 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 580047002156 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 580047002157 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 580047002158 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 580047002159 Phosphoglycerate kinase; Region: PGK; pfam00162 580047002160 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 580047002161 substrate binding site [chemical binding]; other site 580047002162 hinge regions; other site 580047002163 ADP binding site [chemical binding]; other site 580047002164 catalytic site [active] 580047002165 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 580047002166 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 580047002167 minor groove reading motif; other site 580047002168 helix-hairpin-helix signature motif; other site 580047002169 substrate binding pocket [chemical binding]; other site 580047002170 active site 580047002171 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 580047002172 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 580047002173 trmE is a tRNA modification GTPase; Region: trmE; cd04164 580047002174 G1 box; other site 580047002175 GTP/Mg2+ binding site [chemical binding]; other site 580047002176 Switch I region; other site 580047002177 G2 box; other site 580047002178 Switch II region; other site 580047002179 G3 box; other site 580047002180 G4 box; other site 580047002181 G5 box; other site 580047002182 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 580047002183 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 580047002184 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 580047002185 binding surface 580047002186 TPR motif; other site 580047002187 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899 580047002188 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 580047002189 ATP binding site [chemical binding]; other site 580047002190 putative Mg++ binding site [ion binding]; other site 580047002191 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 580047002192 Predicted GTPases [General function prediction only]; Region: COG1160 580047002193 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 580047002194 G1 box; other site 580047002195 GTP/Mg2+ binding site [chemical binding]; other site 580047002196 Switch I region; other site 580047002197 G2 box; other site 580047002198 Switch II region; other site 580047002199 G3 box; other site 580047002200 G4 box; other site 580047002201 G5 box; other site 580047002202 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 580047002203 G1 box; other site 580047002204 GTP/Mg2+ binding site [chemical binding]; other site 580047002205 Switch I region; other site 580047002206 G2 box; other site 580047002207 G3 box; other site 580047002208 Switch II region; other site 580047002209 G4 box; other site 580047002210 G5 box; other site 580047002211 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 580047002212 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 580047002213 active site 580047002214 NTP binding site [chemical binding]; other site 580047002215 metal binding triad [ion binding]; metal-binding site 580047002216 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 580047002217 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 580047002218 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 580047002219 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 580047002220 Walker A motif; other site 580047002221 ATP binding site [chemical binding]; other site 580047002222 Walker B motif; other site 580047002223 arginine finger; other site 580047002224 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 580047002225 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 580047002226 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 580047002227 oligomer interface [polypeptide binding]; other site 580047002228 active site residues [active] 580047002229 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544 580047002230 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 580047002231 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 580047002232 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 580047002233 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 580047002234 ATP binding site [chemical binding]; other site 580047002235 putative Mg++ binding site [ion binding]; other site 580047002236 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 580047002237 nucleotide binding region [chemical binding]; other site 580047002238 ATP-binding site [chemical binding]; other site 580047002239 rod shape-determining protein MreB; Provisional; Region: PRK13927 580047002240 MreB and similar proteins; Region: MreB_like; cd10225 580047002241 nucleotide binding site [chemical binding]; other site 580047002242 Mg binding site [ion binding]; other site 580047002243 putative protofilament interaction site [polypeptide binding]; other site 580047002244 RodZ interaction site [polypeptide binding]; other site 580047002245 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 580047002246 active site 580047002247 substrate-binding site [chemical binding]; other site 580047002248 metal-binding site [ion binding] 580047002249 GTP binding site [chemical binding]; other site 580047002250 Effector from type III secretion system; Region: Effector_1; pfam04518 580047002251 Effector from type III secretion system; Region: Effector_1; pfam04518 580047002252 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 580047002253 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 580047002254 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 580047002255 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 580047002256 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 580047002257 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 580047002258 active site 580047002259 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 580047002260 type III secretion system ATPase; Validated; Region: PRK05922 580047002261 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 580047002262 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 580047002263 Walker A motif; other site 580047002264 ATP binding site [chemical binding]; other site 580047002265 Walker B motif; other site 580047002266 type III secretion system protein; Validated; Region: PRK05934 580047002267 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 580047002268 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 580047002269 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 580047002270 active site 580047002271 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 580047002272 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 580047002273 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 580047002274 catalytic residue [active] 580047002275 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 580047002276 catalytic core [active] 580047002277 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 580047002278 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 580047002279 RNA binding surface [nucleotide binding]; other site 580047002280 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 580047002281 active site 580047002282 biotin--protein ligase; Provisional; Region: PRK05935 580047002283 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 580047002284 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 580047002285 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 580047002286 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 580047002287 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 580047002288 motif II; other site 580047002289 CCC1-related protein family; Region: CCC1_like_1; cd02437 580047002290 seryl-tRNA synthetase; Provisional; Region: PRK05431 580047002291 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 580047002292 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 580047002293 dimer interface [polypeptide binding]; other site 580047002294 active site 580047002295 motif 1; other site 580047002296 motif 2; other site 580047002297 motif 3; other site 580047002298 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 580047002299 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 580047002300 catalytic motif [active] 580047002301 Zn binding site [ion binding]; other site 580047002302 RibD C-terminal domain; Region: RibD_C; pfam01872 580047002303 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 580047002304 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 580047002305 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 580047002306 dimerization interface [polypeptide binding]; other site 580047002307 active site 580047002308 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 580047002309 homopentamer interface [polypeptide binding]; other site 580047002310 active site 580047002311 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 580047002312 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 580047002313 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 580047002314 substrate binding site [chemical binding]; other site 580047002315 Proteins containing SET domain [General function prediction only]; Region: COG2940 580047002316 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 580047002317 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 580047002318 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 580047002319 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 580047002320 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 580047002321 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 580047002322 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Region: NqrF; COG2871 580047002323 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 580047002324 catalytic loop [active] 580047002325 iron binding site [ion binding]; other site 580047002326 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 580047002327 FAD binding pocket [chemical binding]; other site 580047002328 FAD binding motif [chemical binding]; other site 580047002329 phosphate binding motif [ion binding]; other site 580047002330 beta-alpha-beta structure motif; other site 580047002331 NAD binding pocket [chemical binding]; other site 580047002332 preprotein translocase, YajC subunit; Region: yajC; TIGR00739 580047002333 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 580047002334 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 580047002335 S-adenosylmethionine binding site [chemical binding]; other site 580047002336 Histone H1-like protein Hc1; Region: Hc1; pfam07432 580047002337 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 580047002338 binding surface 580047002339 TPR motif; other site 580047002340 Tetratricopeptide repeat; Region: TPR_12; pfam13424 580047002341 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 580047002342 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 580047002343 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 580047002344 HemN C-terminal domain; Region: HemN_C; pfam06969 580047002345 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 580047002346 substrate binding site [chemical binding]; other site 580047002347 active site 580047002348 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 580047002349 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 580047002350 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 580047002351 ATP binding site [chemical binding]; other site 580047002352 putative Mg++ binding site [ion binding]; other site 580047002353 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 580047002354 nucleotide binding region [chemical binding]; other site 580047002355 ATP-binding site [chemical binding]; other site 580047002356 TRCF domain; Region: TRCF; pfam03461 580047002357 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 580047002358 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 580047002359 motif 1; other site 580047002360 active site 580047002361 motif 2; other site 580047002362 motif 3; other site 580047002363 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 580047002364 DHHA1 domain; Region: DHHA1; pfam02272 580047002365 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 580047002366 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 580047002367 TPP-binding site [chemical binding]; other site 580047002368 dimer interface [polypeptide binding]; other site 580047002369 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 580047002370 PYR/PP interface [polypeptide binding]; other site 580047002371 dimer interface [polypeptide binding]; other site 580047002372 TPP binding site [chemical binding]; other site 580047002373 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 580047002374 AMP nucleosidase, putative; Region: AMN-like; TIGR01721 580047002375 elongation factor P; Validated; Region: PRK00529 580047002376 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 580047002377 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 580047002378 RNA binding site [nucleotide binding]; other site 580047002379 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 580047002380 RNA binding site [nucleotide binding]; other site 580047002381 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 580047002382 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 580047002383 putative active site [active] 580047002384 putative metal binding site [ion binding]; other site 580047002385 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 580047002386 active site 580047002387 metal binding site [ion binding]; metal-binding site 580047002388 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 580047002389 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 580047002390 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 580047002391 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 580047002392 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 580047002393 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 580047002394 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 580047002395 Mg++ binding site [ion binding]; other site 580047002396 putative catalytic motif [active] 580047002397 putative substrate binding site [chemical binding]; other site 580047002398 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00683 580047002399 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 580047002400 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 580047002401 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 580047002402 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 580047002403 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 580047002404 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 580047002405 cell division protein FtsW; Region: ftsW; TIGR02614 580047002406 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 580047002407 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 580047002408 active site 580047002409 homodimer interface [polypeptide binding]; other site 580047002410 bifunctional D-alanyl-alanine synthetase A/UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: PRK14573 580047002411 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 580047002412 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 580047002413 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 580047002414 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 580047002415 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 580047002416 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 580047002417 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cd02409 580047002418 G-X-X-G motif; other site 580047002419 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 580047002420 anti sigma factor interaction site; other site 580047002421 regulatory phosphorylation site [posttranslational modification]; other site 580047002422 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 580047002423 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 580047002424 hypothetical protein; Provisional; Region: PRK05927 580047002425 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 580047002426 FeS/SAM binding site; other site 580047002427 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 580047002428 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 580047002429 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 580047002430 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 580047002431 dimer interface [polypeptide binding]; other site 580047002432 active site 580047002433 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 580047002434 active site 580047002435 Ap4A binding cleft/pocket [chemical binding]; other site 580047002436 P4 phosphate binding site; other site 580047002437 nudix motif; other site 580047002438 putative P2/P3 phosphate binding site [ion binding]; other site 580047002439 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 580047002440 dimer interface [polypeptide binding]; other site 580047002441 substrate binding site [chemical binding]; other site 580047002442 metal binding sites [ion binding]; metal-binding site 580047002443 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 580047002444 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 580047002445 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 580047002446 NAD binding site [chemical binding]; other site 580047002447 Phe binding site; other site 580047002448 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 580047002449 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 580047002450 active site 580047002451 putative lithium-binding site [ion binding]; other site 580047002452 substrate binding site [chemical binding]; other site 580047002453 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 580047002454 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 580047002455 putative acyl-acceptor binding pocket; other site 580047002456 long chain fatty acid--[acyl-carrier-protein] ligase; Validated; Region: PRK06334 580047002457 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 580047002458 acyl-activating enzyme (AAE) consensus motif; other site 580047002459 AMP binding site [chemical binding]; other site 580047002460 active site 580047002461 CoA binding site [chemical binding]; other site 580047002462 8-amino-7-oxononanoate synthase; Provisional; Region: PRK05937 580047002463 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 580047002464 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 580047002465 catalytic residue [active] 580047002466 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 580047002467 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 580047002468 ATP binding site [chemical binding]; other site 580047002469 putative Mg++ binding site [ion binding]; other site 580047002470 helicase superfamily c-terminal domain; Region: HELICc; smart00490 580047002471 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 580047002472 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 580047002473 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 580047002474 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 580047002475 dimer interface [polypeptide binding]; other site 580047002476 putative anticodon binding site; other site 580047002477 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 580047002478 motif 1; other site 580047002479 dimer interface [polypeptide binding]; other site 580047002480 active site 580047002481 motif 2; other site 580047002482 motif 3; other site 580047002483 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 580047002484 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 580047002485 active site 580047002486 HIGH motif; other site 580047002487 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 580047002488 KMSKS motif; other site 580047002489 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 580047002490 tRNA binding surface [nucleotide binding]; other site 580047002491 anticodon binding site; other site 580047002492 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 580047002493 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 580047002494 ribonuclease P; Reviewed; Region: rnpA; PRK00730 580047002495 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 580047002496 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 580047002497 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 580047002498 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 580047002499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 580047002500 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 580047002501 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 580047002502 active site 580047002503 catalytic site [active] 580047002504 putative DNA binding site [nucleotide binding]; other site 580047002505 GIY-YIG motif/motif A; other site 580047002506 metal binding site [ion binding]; metal-binding site 580047002507 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 580047002508 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 580047002509 MutS domain I; Region: MutS_I; pfam01624 580047002510 MutS domain II; Region: MutS_II; pfam05188 580047002511 MutS domain III; Region: MutS_III; pfam05192 580047002512 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 580047002513 Walker A/P-loop; other site 580047002514 ATP binding site [chemical binding]; other site 580047002515 Q-loop/lid; other site 580047002516 ABC transporter signature motif; other site 580047002517 Walker B; other site 580047002518 D-loop; other site 580047002519 H-loop/switch region; other site 580047002520 DNA primase; Validated; Region: dnaG; PRK05667 580047002521 CHC2 zinc finger; Region: zf-CHC2; pfam01807 580047002522 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 580047002523 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 580047002524 active site 580047002525 metal binding site [ion binding]; metal-binding site 580047002526 interdomain interaction site; other site 580047002527 glycyl-tRNA synthetase; Provisional; Region: PRK14908 580047002528 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 580047002529 dimer interface [polypeptide binding]; other site 580047002530 motif 1; other site 580047002531 active site 580047002532 motif 2; other site 580047002533 motif 3; other site 580047002534 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 580047002535 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 580047002536 glycogen synthase; Provisional; Region: glgA; PRK00654 580047002537 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 580047002538 ADP-binding pocket [chemical binding]; other site 580047002539 homodimer interface [polypeptide binding]; other site 580047002540 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 580047002541 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 580047002542 5S rRNA interface [nucleotide binding]; other site 580047002543 CTC domain interface [polypeptide binding]; other site 580047002544 L16 interface [polypeptide binding]; other site 580047002545 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 580047002546 putative active site [active] 580047002547 catalytic residue [active] 580047002548 Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360 580047002549 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 580047002550 Ribosomal protein L9 [Translation, ribosomal structure and biogenesis]; Region: RplI; COG0359 580047002551 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 580047002552 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 580047002553 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK00650 580047002554 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 580047002555 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 580047002556 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 580047002557 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 580047002558 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 580047002559 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 580047002560 putative acyl-acceptor binding pocket; other site 580047002561 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 580047002562 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 580047002563 homodimer interface [polypeptide binding]; other site 580047002564 oligonucleotide binding site [chemical binding]; other site 580047002566 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 580047002567 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13846 580047002568 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 580047002569 Autotransporter beta-domain; Region: Autotransporter; pfam03797 580047002570 IncA protein; Region: IncA; pfam04156 580047002571 YtxH-like protein; Region: YtxH; cl02079 580047002572 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 580047002573 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 580047002574 active site 580047002575 substrate binding site [chemical binding]; other site 580047002576 metal binding site [ion binding]; metal-binding site 580047002577 glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135 580047002578 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 580047002579 glutaminase active site [active] 580047002580 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 580047002581 dimer interface [polypeptide binding]; other site 580047002582 active site 580047002583 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 580047002584 dimer interface [polypeptide binding]; other site 580047002585 active site 580047002586 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 580047002587 aromatic amino acid transport protein; Region: araaP; TIGR00837 580047002588 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 580047002589 aromatic amino acid transport protein; Region: araaP; TIGR00837 580047002590 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 580047002591 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 580047002592 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 580047002593 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 580047002594 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 580047002595 succinyl-CoA synthetase, beta subunit; Region: sucCoAbeta; TIGR01016 580047002596 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 580047002597 CoA-ligase; Region: Ligase_CoA; pfam00549 580047002598 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 580047002599 CoA binding domain; Region: CoA_binding; smart00881 580047002600 CoA-ligase; Region: Ligase_CoA; pfam00549 580047002601 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 580047002602 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 580047002603 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 580047002604 protein binding site [polypeptide binding]; other site 580047002605 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 580047002606 protein binding site [polypeptide binding]; other site 580047002607 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 580047002608 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 580047002609 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 580047002610 Peptidase M16C associated; Region: M16C_assoc; pfam08367 580047002611 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 580047002612 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 580047002613 RmuC family; Region: RmuC; pfam02646 580047002614 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 580047002615 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 580047002616 ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12365 580047002617 ATP cone domain; Region: ATP-cone; pfam03477 580047002618 ATP cone domain; Region: ATP-cone; pfam03477 580047002619 Class I ribonucleotide reductase; Region: RNR_I; cd01679 580047002620 active site 580047002621 dimer interface [polypeptide binding]; other site 580047002622 catalytic residues [active] 580047002623 effector binding site; other site 580047002624 R2 peptide binding site; other site 580047002625 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 580047002626 dimer interface [polypeptide binding]; other site 580047002627 putative radical transfer pathway; other site 580047002628 diiron center [ion binding]; other site 580047002629 tyrosyl radical; other site 580047002630 Putative methyltransferase; Region: Methyltransf_4; pfam02390 580047002631 Methyltransferase domain; Region: Methyltransf_18; pfam12847 580047002632 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 580047002633 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 580047002634 FAD binding domain; Region: FAD_binding_4; pfam01565 580047002635 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 580047002636 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 580047002637 putative RNA binding site [nucleotide binding]; other site 580047002638 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 580047002639 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 580047002640 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 580047002641 Ribosomal protein L35 [Translation, ribosomal structure and biogenesis]; Region: RpmI; COG0291 580047002642 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 580047002643 23S rRNA binding site [nucleotide binding]; other site 580047002644 L21 binding site [polypeptide binding]; other site 580047002645 L13 binding site [polypeptide binding]; other site 580047002646 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 580047002647 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 580047002648 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 580047002649 motif 1; other site 580047002650 dimer interface [polypeptide binding]; other site 580047002651 active site 580047002652 motif 2; other site 580047002653 motif 3; other site 580047002654 Predicted permeases [General function prediction only]; Region: COG0795 580047002655 Predicted permeases [General function prediction only]; Region: COG0795 580047002656 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 580047002657 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 580047002658 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 580047002659 Ligand Binding Site [chemical binding]; other site 580047002660 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 580047002661 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 580047002662 Walker A motif; other site 580047002663 ATP binding site [chemical binding]; other site 580047002664 Walker B motif; other site 580047002665 arginine finger; other site 580047002666 Peptidase family M41; Region: Peptidase_M41; pfam01434 580047002667 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 580047002668 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 580047002669 RNase E interface [polypeptide binding]; other site 580047002670 trimer interface [polypeptide binding]; other site 580047002671 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 580047002672 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 580047002673 RNase E interface [polypeptide binding]; other site 580047002674 trimer interface [polypeptide binding]; other site 580047002675 active site 580047002676 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 580047002677 putative nucleic acid binding region [nucleotide binding]; other site 580047002678 G-X-X-G motif; other site 580047002679 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 580047002680 RNA binding site [nucleotide binding]; other site 580047002681 domain interface; other site 580047002682 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 580047002683 16S/18S rRNA binding site [nucleotide binding]; other site 580047002684 S13e-L30e interaction site [polypeptide binding]; other site 580047002685 25S rRNA binding site [nucleotide binding]; other site 580047002686 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 580047002687 nucleoside/Zn binding site; other site 580047002688 dimer interface [polypeptide binding]; other site 580047002689 catalytic motif [active] 580047002690 Protein of unknown function (DUF720); Region: DUF720; pfam05302 580047002691 Protein of unknown function (DUF720); Region: DUF720; pfam05302 580047002692 Protein of unknown function (DUF720); Region: DUF720; pfam05302 580047002693 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 580047002694 methionine aminopeptidase; Provisional; Region: PRK12318 580047002695 SEC-C motif; Region: SEC-C; pfam02810 580047002696 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 580047002697 active site 580047002698 MarC family integral membrane protein; Region: MarC; pfam01914 580047002699 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 580047002700 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 580047002701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580047002702 dimer interface [polypeptide binding]; other site 580047002703 conserved gate region; other site 580047002704 putative PBP binding loops; other site 580047002705 ABC-ATPase subunit interface; other site 580047002706 NMT1/THI5 like; Region: NMT1; pfam09084 580047002708 high affinity sulphate transporter 1; Region: sulP; TIGR00815 580047002709 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 580047002710 Sulfate transporter family; Region: Sulfate_transp; pfam00916 580047002711 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 580047002712 Na+/H+ antiporter, NhaD family; Region: NhaD; TIGR00775 580047002713 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 580047002714 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 580047002715 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 580047002716 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 580047002717 active site triad [active] 580047002718 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 580047002719 LytB protein; Region: LYTB; pfam02401 580047002720 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 580047002721 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 580047002722 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 580047002723 binding surface 580047002724 TPR motif; other site 580047002725 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 580047002726 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 580047002727 active site 580047002728 DNA binding site [nucleotide binding] 580047002729 Int/Topo IB signature motif; other site 580047002730 glycogen branching enzyme; Provisional; Region: PRK05402 580047002731 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 580047002732 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 580047002733 active site 580047002734 catalytic site [active] 580047002735 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 580047002736 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 580047002737 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 580047002738 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 580047002739 Autotransporter beta-domain; Region: Autotransporter; pfam03797 580047002740 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 580047002741 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 580047002742 Autotransporter beta-domain; Region: Autotransporter; pfam03797 580047002743 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 580047002744 Autotransporter beta-domain; Region: Autotransporter; pfam03797 580047002745 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 580047002746 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 580047002747 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 580047002748 Autotransporter beta-domain; Region: Autotransporter; pfam03797 580047002749 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 580047002750 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 580047002751 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 580047002752 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 580047002753 Autotransporter beta-domain; Region: Autotransporter; pfam03797