-- dump date 20140619_030618 -- class Genbank::misc_feature -- table misc_feature_note -- id note 867900000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 867900000002 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 867900000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 867900000004 Walker A motif; other site 867900000005 ATP binding site [chemical binding]; other site 867900000006 Walker B motif; other site 867900000007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 867900000008 arginine finger; other site 867900000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 867900000010 DnaA box-binding interface [nucleotide binding]; other site 867900000011 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 867900000012 Low molecular weight phosphatase family; Region: LMWPc; cd00115 867900000013 active site 867900000014 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 867900000015 putative SAM binding site [chemical binding]; other site 867900000016 homodimer interface [polypeptide binding]; other site 867900000017 YceG-like family; Region: YceG; pfam02618 867900000018 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 867900000019 dimerization interface [polypeptide binding]; other site 867900000020 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 867900000021 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 867900000022 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 867900000023 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 867900000024 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 867900000025 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 867900000026 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 867900000027 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 867900000028 protein binding site [polypeptide binding]; other site 867900000029 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 867900000030 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 867900000031 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 867900000032 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 867900000033 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 867900000034 Coenzyme A binding pocket [chemical binding]; other site 867900000035 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 867900000036 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 867900000037 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 867900000038 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 867900000039 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900000040 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900000041 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 867900000042 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 867900000043 phosphodiesterase; Provisional; Region: PRK12704 867900000044 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 867900000045 Zn2+ binding site [ion binding]; other site 867900000046 Mg2+ binding site [ion binding]; other site 867900000047 Cell division protein ZapA; Region: ZapA; pfam05164 867900000048 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 867900000049 Peptidase family M23; Region: Peptidase_M23; pfam01551 867900000050 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 867900000051 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 867900000052 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 867900000053 catalytic residue [active] 867900000054 Smr domain; Region: Smr; pfam01713 867900000055 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 867900000056 Interferon-induced transmembrane protein; Region: CD225; pfam04505 867900000057 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 867900000058 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 867900000059 ATP binding site [chemical binding]; other site 867900000060 putative Mg++ binding site [ion binding]; other site 867900000061 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 867900000062 nucleotide binding region [chemical binding]; other site 867900000063 ATP-binding site [chemical binding]; other site 867900000064 RQC domain; Region: RQC; pfam09382 867900000065 HRDC domain; Region: HRDC; pfam00570 867900000066 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 867900000067 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 867900000068 putative active site [active] 867900000069 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 867900000070 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 867900000071 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 867900000072 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 867900000073 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 867900000074 Walker A/P-loop; other site 867900000075 ATP binding site [chemical binding]; other site 867900000076 Q-loop/lid; other site 867900000077 ABC transporter signature motif; other site 867900000078 Walker B; other site 867900000079 D-loop; other site 867900000080 H-loop/switch region; other site 867900000081 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 867900000082 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 867900000083 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 867900000084 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 867900000085 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 867900000086 Walker A/P-loop; other site 867900000087 ATP binding site [chemical binding]; other site 867900000088 Q-loop/lid; other site 867900000089 ABC transporter signature motif; other site 867900000090 Walker B; other site 867900000091 D-loop; other site 867900000092 H-loop/switch region; other site 867900000093 ABC transporter; Region: ABC_tran_2; pfam12848 867900000094 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 867900000095 SdpI/YhfL protein family; Region: SdpI; pfam13630 867900000096 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 867900000097 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 867900000098 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 867900000099 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 867900000100 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 867900000101 nucleotide binding region [chemical binding]; other site 867900000102 ATP-binding site [chemical binding]; other site 867900000103 Peptidase family M23; Region: Peptidase_M23; pfam01551 867900000104 methionine sulfoxide reductase A; Provisional; Region: PRK14054 867900000105 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 867900000106 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 867900000107 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 867900000108 DNA binding residues [nucleotide binding] 867900000109 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 867900000110 membrane ATPase/protein kinase; Provisional; Region: PRK09435 867900000111 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 867900000112 Walker A; other site 867900000113 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 867900000114 active site 867900000115 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 867900000116 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 867900000117 active site 867900000118 multidrug efflux protein; Reviewed; Region: PRK01766 867900000119 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 867900000120 cation binding site [ion binding]; other site 867900000121 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 867900000122 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 867900000123 homodimer interface [polypeptide binding]; other site 867900000124 metal binding site [ion binding]; metal-binding site 867900000125 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 867900000126 homodimer interface [polypeptide binding]; other site 867900000127 active site 867900000128 putative chemical substrate binding site [chemical binding]; other site 867900000129 metal binding site [ion binding]; metal-binding site 867900000130 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 867900000131 helicase 45; Provisional; Region: PTZ00424 867900000132 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 867900000133 ATP binding site [chemical binding]; other site 867900000134 Mg++ binding site [ion binding]; other site 867900000135 motif III; other site 867900000136 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 867900000137 nucleotide binding region [chemical binding]; other site 867900000138 ATP-binding site [chemical binding]; other site 867900000139 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 867900000140 active site 867900000141 catalytic triad [active] 867900000142 oxyanion hole [active] 867900000143 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 867900000144 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 867900000145 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 867900000146 active site 867900000147 Response regulator receiver domain; Region: Response_reg; pfam00072 867900000148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900000149 active site 867900000150 phosphorylation site [posttranslational modification] 867900000151 intermolecular recognition site; other site 867900000152 dimerization interface [polypeptide binding]; other site 867900000153 PAS fold; Region: PAS; pfam00989 867900000154 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 867900000155 putative active site [active] 867900000156 heme pocket [chemical binding]; other site 867900000157 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 867900000158 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 867900000159 dimer interface [polypeptide binding]; other site 867900000160 phosphorylation site [posttranslational modification] 867900000161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900000162 ATP binding site [chemical binding]; other site 867900000163 Mg2+ binding site [ion binding]; other site 867900000164 G-X-G motif; other site 867900000165 MORN repeat; Region: MORN; cl14787 867900000166 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900000167 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900000168 binding surface 867900000169 TPR motif; other site 867900000170 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900000171 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900000172 binding surface 867900000173 TPR motif; other site 867900000174 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900000175 Histidine kinase; Region: His_kinase; pfam06580 867900000176 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 867900000177 ATP binding site [chemical binding]; other site 867900000178 Mg2+ binding site [ion binding]; other site 867900000179 G-X-G motif; other site 867900000180 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 867900000181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900000182 active site 867900000183 phosphorylation site [posttranslational modification] 867900000184 intermolecular recognition site; other site 867900000185 dimerization interface [polypeptide binding]; other site 867900000186 LytTr DNA-binding domain; Region: LytTR; smart00850 867900000187 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 867900000188 active site 867900000189 catalytic residues [active] 867900000190 metal binding site [ion binding]; metal-binding site 867900000191 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 867900000192 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 867900000193 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 867900000194 trimer interface [polypeptide binding]; other site 867900000195 active site 867900000196 substrate binding site [chemical binding]; other site 867900000197 CoA binding site [chemical binding]; other site 867900000198 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 867900000199 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 867900000200 Substrate binding site; other site 867900000201 metal-binding site 867900000202 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 867900000203 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 867900000204 active site 867900000205 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 867900000206 active site 867900000207 metal-binding site 867900000208 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 867900000209 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 867900000210 putative metal binding site; other site 867900000211 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 867900000212 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 867900000213 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 867900000214 active site 867900000215 NTP binding site [chemical binding]; other site 867900000216 metal binding triad [ion binding]; metal-binding site 867900000217 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 867900000218 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 867900000219 Zn2+ binding site [ion binding]; other site 867900000220 Mg2+ binding site [ion binding]; other site 867900000221 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 867900000222 Domain of unknown function DUF11; Region: DUF11; cl17728 867900000223 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 867900000224 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 867900000225 TPR repeat; Region: TPR_11; pfam13414 867900000226 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 867900000227 TPR motif; other site 867900000228 binding surface 867900000229 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 867900000230 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 867900000231 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 867900000232 ligand binding site [chemical binding]; other site 867900000233 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 867900000234 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 867900000235 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 867900000236 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 867900000237 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 867900000238 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 867900000239 conserved repeat domain; Region: B_ant_repeat; TIGR01451 867900000240 Domain of unknown function DUF11; Region: DUF11; cl17728 867900000241 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 867900000242 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 867900000243 Walker A/P-loop; other site 867900000244 ATP binding site [chemical binding]; other site 867900000245 Q-loop/lid; other site 867900000246 ABC transporter signature motif; other site 867900000247 Walker B; other site 867900000248 D-loop; other site 867900000249 H-loop/switch region; other site 867900000250 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 867900000251 Immunoglobulin domain; Region: Ig_2; pfam13895 867900000252 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 867900000253 excinuclease ABC subunit B; Provisional; Region: PRK05298 867900000254 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 867900000255 ATP binding site [chemical binding]; other site 867900000256 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 867900000257 nucleotide binding region [chemical binding]; other site 867900000258 ATP-binding site [chemical binding]; other site 867900000259 Ultra-violet resistance protein B; Region: UvrB; pfam12344 867900000260 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 867900000261 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 867900000262 putative dimer interface [polypeptide binding]; other site 867900000263 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 867900000264 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 867900000265 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 867900000266 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 867900000267 CoA-ligase; Region: Ligase_CoA; pfam00549 867900000268 diaminopimelate decarboxylase; Region: lysA; TIGR01048 867900000269 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 867900000270 active site 867900000271 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 867900000272 substrate binding site [chemical binding]; other site 867900000273 catalytic residues [active] 867900000274 dimer interface [polypeptide binding]; other site 867900000275 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 867900000276 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 867900000277 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 867900000278 arsenical-resistance protein; Region: acr3; TIGR00832 867900000279 Low molecular weight phosphatase family; Region: LMWPc; cl00105 867900000280 active site 867900000281 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 867900000282 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 867900000283 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 867900000284 dimerization interface [polypeptide binding]; other site 867900000285 putative DNA binding site [nucleotide binding]; other site 867900000286 putative Zn2+ binding site [ion binding]; other site 867900000287 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 867900000288 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 867900000289 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 867900000290 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 867900000291 active site 867900000292 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900000293 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900000294 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 867900000295 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 867900000296 Imelysin; Region: Peptidase_M75; pfam09375 867900000297 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 867900000298 active site 867900000299 catalytic residues [active] 867900000300 metal binding site [ion binding]; metal-binding site 867900000301 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 867900000302 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 867900000303 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 867900000304 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 867900000305 quinone interaction residues [chemical binding]; other site 867900000306 active site 867900000307 catalytic residues [active] 867900000308 FMN binding site [chemical binding]; other site 867900000309 substrate binding site [chemical binding]; other site 867900000310 peptidase T; Region: peptidase-T; TIGR01882 867900000311 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 867900000312 metal binding site [ion binding]; metal-binding site 867900000313 dimer interface [polypeptide binding]; other site 867900000314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 867900000315 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 867900000316 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 867900000317 Preprotein translocase subunit; Region: YajC; pfam02699 867900000318 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 867900000319 transcription antitermination factor NusB; Region: nusB; TIGR01951 867900000320 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 867900000321 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 867900000322 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 867900000323 Walker A/P-loop; other site 867900000324 ATP binding site [chemical binding]; other site 867900000325 Q-loop/lid; other site 867900000326 ABC transporter signature motif; other site 867900000327 Walker B; other site 867900000328 D-loop; other site 867900000329 H-loop/switch region; other site 867900000330 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 867900000331 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 867900000332 putative active site [active] 867900000333 Zn binding site [ion binding]; other site 867900000334 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 867900000335 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 867900000336 dimer interface [polypeptide binding]; other site 867900000337 putative tRNA-binding site [nucleotide binding]; other site 867900000338 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 867900000339 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 867900000340 putative catalytic residue [active] 867900000341 metal-dependent hydrolase; Provisional; Region: PRK13291 867900000342 DinB superfamily; Region: DinB_2; pfam12867 867900000343 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 867900000344 active site 867900000345 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 867900000346 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 867900000347 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 867900000348 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 867900000349 PA/protease or protease-like domain interface [polypeptide binding]; other site 867900000350 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 867900000351 Peptidase family M28; Region: Peptidase_M28; pfam04389 867900000352 metal binding site [ion binding]; metal-binding site 867900000353 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 867900000354 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 867900000355 putative hydrophobic ligand binding site [chemical binding]; other site 867900000356 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 867900000357 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 867900000358 NAD-dependent deacetylase; Provisional; Region: PRK00481 867900000359 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 867900000360 NAD+ binding site [chemical binding]; other site 867900000361 substrate binding site [chemical binding]; other site 867900000362 Zn binding site [ion binding]; other site 867900000363 Haem-binding domain; Region: Haem_bd; pfam14376 867900000364 adenylosuccinate lyase; Provisional; Region: PRK09285 867900000365 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 867900000366 tetramer interface [polypeptide binding]; other site 867900000367 active site 867900000368 Endonuclease I; Region: Endonuclease_1; pfam04231 867900000369 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 867900000370 Interdomain contacts; other site 867900000371 Cytokine receptor motif; other site 867900000372 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 867900000373 putative catalytic site [active] 867900000374 putative metal binding site [ion binding]; other site 867900000375 putative phosphate binding site [ion binding]; other site 867900000376 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 867900000377 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 867900000378 mechanosensitive channel MscS; Provisional; Region: PRK10334 867900000379 Conserved TM helix; Region: TM_helix; pfam05552 867900000380 Mechanosensitive ion channel; Region: MS_channel; pfam00924 867900000381 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 867900000382 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 867900000383 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 867900000384 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 867900000385 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 867900000386 DNA binding residues [nucleotide binding] 867900000387 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 867900000388 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 867900000389 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 867900000390 Catalytic dyad [active] 867900000391 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 867900000392 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900000393 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 867900000394 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 867900000395 putative ligand binding site [chemical binding]; other site 867900000396 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 867900000397 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 867900000398 ABC-ATPase subunit interface; other site 867900000399 dimer interface [polypeptide binding]; other site 867900000400 putative PBP binding regions; other site 867900000401 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 867900000402 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 867900000403 Walker A/P-loop; other site 867900000404 ATP binding site [chemical binding]; other site 867900000405 Q-loop/lid; other site 867900000406 ABC transporter signature motif; other site 867900000407 Walker B; other site 867900000408 D-loop; other site 867900000409 H-loop/switch region; other site 867900000410 RmuC family; Region: RmuC; pfam02646 867900000411 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 867900000412 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900000413 TPR motif; other site 867900000414 binding surface 867900000415 Histidine kinase; Region: His_kinase; pfam06580 867900000416 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 867900000417 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 867900000418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900000419 active site 867900000420 phosphorylation site [posttranslational modification] 867900000421 intermolecular recognition site; other site 867900000422 dimerization interface [polypeptide binding]; other site 867900000423 LytTr DNA-binding domain; Region: LytTR; pfam04397 867900000424 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 867900000425 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 867900000426 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 867900000427 ATP-grasp domain; Region: ATP-grasp_4; cl17255 867900000428 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 867900000429 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 867900000430 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 867900000431 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 867900000432 ATP-grasp domain; Region: ATP-grasp_4; cl17255 867900000433 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 867900000434 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 867900000435 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 867900000436 N-acetyl-D-glucosamine binding site [chemical binding]; other site 867900000437 catalytic residue [active] 867900000438 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 867900000439 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 867900000440 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 867900000441 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 867900000442 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 867900000443 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 867900000444 EamA-like transporter family; Region: EamA; pfam00892 867900000445 EamA-like transporter family; Region: EamA; pfam00892 867900000446 ribonuclease Z; Reviewed; Region: PRK00055 867900000447 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 867900000448 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 867900000449 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 867900000450 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 867900000451 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 867900000452 active site 867900000453 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 867900000454 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 867900000455 RNA binding site [nucleotide binding]; other site 867900000456 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 867900000457 RNA binding site [nucleotide binding]; other site 867900000458 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 867900000459 RNA binding site [nucleotide binding]; other site 867900000460 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 867900000461 RNA binding site [nucleotide binding]; other site 867900000462 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 867900000463 RNA binding site [nucleotide binding]; other site 867900000464 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 867900000465 RNA binding site [nucleotide binding]; other site 867900000466 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 867900000467 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 867900000468 cytidylate kinase; Provisional; Region: cmk; PRK00023 867900000469 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 867900000470 CMP-binding site; other site 867900000471 The sites determining sugar specificity; other site 867900000472 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 867900000473 Found in ATP-dependent protease La (LON); Region: LON; smart00464 867900000474 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 867900000475 Walker A motif; other site 867900000476 ATP binding site [chemical binding]; other site 867900000477 Walker B motif; other site 867900000478 arginine finger; other site 867900000479 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 867900000480 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 867900000481 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 867900000482 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 867900000483 DNA binding residues [nucleotide binding] 867900000484 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 867900000485 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 867900000486 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 867900000487 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 867900000488 Peptidase family M48; Region: Peptidase_M48; pfam01435 867900000489 methionine sulfoxide reductase B; Provisional; Region: PRK00222 867900000490 SelR domain; Region: SelR; pfam01641 867900000491 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 867900000492 SelR domain; Region: SelR; pfam01641 867900000493 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 867900000494 DinB superfamily; Region: DinB_2; pfam12867 867900000495 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 867900000496 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 867900000497 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 867900000498 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 867900000499 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 867900000500 integral membrane protein; Region: integ_memb_HG; TIGR03954 867900000501 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 867900000502 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 867900000503 Ligand Binding Site [chemical binding]; other site 867900000504 Dehydroquinase class II; Region: DHquinase_II; pfam01220 867900000505 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 867900000506 active site 867900000507 trimer interface [polypeptide binding]; other site 867900000508 dimer interface [polypeptide binding]; other site 867900000509 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 867900000510 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 867900000511 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 867900000512 active site 867900000513 Int/Topo IB signature motif; other site 867900000514 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 867900000515 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 867900000516 DNA binding residues [nucleotide binding] 867900000517 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 867900000518 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 867900000519 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 867900000520 putative acyl-acceptor binding pocket; other site 867900000521 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 867900000522 putative active site [active] 867900000523 putative CoA binding site [chemical binding]; other site 867900000524 nudix motif; other site 867900000525 metal binding site [ion binding]; metal-binding site 867900000526 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 867900000527 active site 867900000528 Predicted membrane protein [Function unknown]; Region: COG2860 867900000529 UPF0126 domain; Region: UPF0126; pfam03458 867900000530 UPF0126 domain; Region: UPF0126; pfam03458 867900000531 RDD family; Region: RDD; pfam06271 867900000532 Integral membrane protein DUF95; Region: DUF95; pfam01944 867900000533 Uncharacterized protein family (UPF0259); Region: UPF0259; cl11642 867900000534 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 867900000535 MoxR-like ATPases [General function prediction only]; Region: COG0714 867900000536 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 867900000537 Walker A motif; other site 867900000538 ATP binding site [chemical binding]; other site 867900000539 Walker B motif; other site 867900000540 arginine finger; other site 867900000541 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 867900000542 Protein of unknown function DUF58; Region: DUF58; pfam01882 867900000543 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 867900000544 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 867900000545 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 867900000546 dimer interface [polypeptide binding]; other site 867900000547 phosphorylation site [posttranslational modification] 867900000548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900000549 ATP binding site [chemical binding]; other site 867900000550 Mg2+ binding site [ion binding]; other site 867900000551 G-X-G motif; other site 867900000552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900000553 Response regulator receiver domain; Region: Response_reg; pfam00072 867900000554 active site 867900000555 phosphorylation site [posttranslational modification] 867900000556 intermolecular recognition site; other site 867900000557 dimerization interface [polypeptide binding]; other site 867900000558 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 867900000559 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 867900000560 intersubunit interface [polypeptide binding]; other site 867900000561 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 867900000562 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 867900000563 FMN binding site [chemical binding]; other site 867900000564 substrate binding site [chemical binding]; other site 867900000565 putative catalytic residue [active] 867900000566 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 867900000567 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 867900000568 membrane protein insertase; Provisional; Region: PRK01318 867900000569 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 867900000570 CTP synthetase; Validated; Region: pyrG; PRK05380 867900000571 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 867900000572 Catalytic site [active] 867900000573 active site 867900000574 UTP binding site [chemical binding]; other site 867900000575 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 867900000576 active site 867900000577 putative oxyanion hole; other site 867900000578 catalytic triad [active] 867900000579 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 867900000580 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 867900000581 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 867900000582 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 867900000583 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 867900000584 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 867900000585 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 867900000586 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 867900000587 ligand binding site [chemical binding]; other site 867900000588 GMP synthase; Reviewed; Region: guaA; PRK00074 867900000589 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 867900000590 AMP/PPi binding site [chemical binding]; other site 867900000591 candidate oxyanion hole; other site 867900000592 catalytic triad [active] 867900000593 potential glutamine specificity residues [chemical binding]; other site 867900000594 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 867900000595 ATP Binding subdomain [chemical binding]; other site 867900000596 Ligand Binding sites [chemical binding]; other site 867900000597 Dimerization subdomain; other site 867900000598 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 867900000599 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 867900000600 catalytic residue [active] 867900000601 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 867900000602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 867900000603 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900000604 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 867900000605 dimer interface [polypeptide binding]; other site 867900000606 catalytic triad [active] 867900000607 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 867900000608 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 867900000609 inhibitor-cofactor binding pocket; inhibition site 867900000610 pyridoxal 5'-phosphate binding site [chemical binding]; other site 867900000611 catalytic residue [active] 867900000612 TRAM domain; Region: TRAM; pfam01938 867900000613 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 867900000614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 867900000615 S-adenosylmethionine binding site [chemical binding]; other site 867900000616 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 867900000617 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 867900000618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 867900000619 ZIP Zinc transporter; Region: Zip; pfam02535 867900000620 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 867900000621 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 867900000622 Haemolysin-III related; Region: HlyIII; cl03831 867900000623 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 867900000624 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 867900000625 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 867900000626 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 867900000627 putative active site [active] 867900000628 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 867900000629 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 867900000630 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 867900000631 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 867900000632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 867900000633 putative substrate translocation pore; other site 867900000634 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 867900000635 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 867900000636 ATP-binding site [chemical binding]; other site 867900000637 Sugar specificity; other site 867900000638 Pyrimidine base specificity; other site 867900000639 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 867900000640 Septum formation initiator; Region: DivIC; cl17659 867900000641 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 867900000642 heterodimer interface [polypeptide binding]; other site 867900000643 substrate interaction site [chemical binding]; other site 867900000644 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 867900000645 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 867900000646 active site 867900000647 substrate binding site [chemical binding]; other site 867900000648 coenzyme B12 binding site [chemical binding]; other site 867900000649 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 867900000650 B12 binding site [chemical binding]; other site 867900000651 cobalt ligand [ion binding]; other site 867900000652 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 867900000653 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 867900000654 P-loop; other site 867900000655 Magnesium ion binding site [ion binding]; other site 867900000656 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 867900000657 Magnesium ion binding site [ion binding]; other site 867900000658 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 867900000659 ParB-like nuclease domain; Region: ParBc; pfam02195 867900000660 dihydrodipicolinate reductase; Provisional; Region: PRK00048 867900000661 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 867900000662 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 867900000663 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 867900000664 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 867900000665 Catalytic site [active] 867900000666 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 867900000667 WbqC-like protein family; Region: WbqC; pfam08889 867900000668 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 867900000669 putative catalytic site [active] 867900000670 putative metal binding site [ion binding]; other site 867900000671 putative phosphate binding site [ion binding]; other site 867900000672 Rhomboid family; Region: Rhomboid; pfam01694 867900000673 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 867900000674 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 867900000675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900000676 ATP binding site [chemical binding]; other site 867900000677 Mg2+ binding site [ion binding]; other site 867900000678 G-X-G motif; other site 867900000679 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 867900000680 ATP binding site [chemical binding]; other site 867900000681 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 867900000682 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 867900000683 homopentamer interface [polypeptide binding]; other site 867900000684 active site 867900000685 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 867900000686 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900000687 binding surface 867900000688 TPR motif; other site 867900000689 recombination protein F; Reviewed; Region: recF; PRK00064 867900000690 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 867900000691 Walker A/P-loop; other site 867900000692 ATP binding site [chemical binding]; other site 867900000693 Q-loop/lid; other site 867900000694 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 867900000695 ABC transporter signature motif; other site 867900000696 Walker B; other site 867900000697 D-loop; other site 867900000698 H-loop/switch region; other site 867900000699 Protein of unknown function (DUF721); Region: DUF721; pfam05258 867900000700 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 867900000701 active site 867900000702 multimer interface [polypeptide binding]; other site 867900000703 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 867900000704 putative active site [active] 867900000705 putative metal binding site [ion binding]; other site 867900000706 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 867900000707 DHH family; Region: DHH; pfam01368 867900000708 DHHA1 domain; Region: DHHA1; pfam02272 867900000709 peptidyl-prolyl isomerase, gliding motility-associated; Region: ppisom_GldI; TIGR03516 867900000710 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 867900000711 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 867900000712 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 867900000713 active site 867900000714 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 867900000715 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 867900000716 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 867900000717 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 867900000718 metal binding site [ion binding]; metal-binding site 867900000719 dimer interface [polypeptide binding]; other site 867900000720 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 867900000721 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 867900000722 active site 867900000723 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 867900000724 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 867900000725 Amidohydrolase; Region: Amidohydro_4; pfam13147 867900000726 active site 867900000727 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 867900000728 Amidohydrolase; Region: Amidohydro_4; pfam13147 867900000729 active site 867900000730 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 867900000731 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 867900000732 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 867900000733 Peptidase family M48; Region: Peptidase_M48; pfam01435 867900000734 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 867900000735 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 867900000736 Zn2+ binding site [ion binding]; other site 867900000737 Mg2+ binding site [ion binding]; other site 867900000738 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 867900000739 synthetase active site [active] 867900000740 NTP binding site [chemical binding]; other site 867900000741 metal binding site [ion binding]; metal-binding site 867900000742 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 867900000743 ACT domain; Region: ACT_4; pfam13291 867900000744 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 867900000745 metal binding site 2 [ion binding]; metal-binding site 867900000746 putative DNA binding helix; other site 867900000747 metal binding site 1 [ion binding]; metal-binding site 867900000748 dimer interface [polypeptide binding]; other site 867900000749 structural Zn2+ binding site [ion binding]; other site 867900000750 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 867900000751 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 867900000752 GDP-binding site [chemical binding]; other site 867900000753 ACT binding site; other site 867900000754 IMP binding site; other site 867900000755 OstA-like protein; Region: OstA_2; pfam13100 867900000756 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 867900000757 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 867900000758 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 867900000759 inhibitor-cofactor binding pocket; inhibition site 867900000760 pyridoxal 5'-phosphate binding site [chemical binding]; other site 867900000761 catalytic residue [active] 867900000762 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 867900000763 binding surface 867900000764 TPR motif; other site 867900000765 TPR repeat; Region: TPR_11; pfam13414 867900000766 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900000767 binding surface 867900000768 TPR motif; other site 867900000769 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900000770 binding surface 867900000771 TPR motif; other site 867900000772 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900000773 TPR motif; other site 867900000774 binding surface 867900000775 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900000776 TPR repeat; Region: TPR_11; pfam13414 867900000777 binding surface 867900000778 TPR motif; other site 867900000779 Domain of unknown function (DUF368); Region: DUF368; pfam04018 867900000780 Domain of unknown function (DUF368); Region: DUF368; pfam04018 867900000781 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 867900000782 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 867900000783 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 867900000784 shikimate binding site; other site 867900000785 NAD(P) binding site [chemical binding]; other site 867900000786 threonine synthase; Validated; Region: PRK09225 867900000787 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 867900000788 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 867900000789 catalytic residue [active] 867900000790 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 867900000791 NADH(P)-binding; Region: NAD_binding_10; pfam13460 867900000792 NAD(P) binding site [chemical binding]; other site 867900000793 putative active site [active] 867900000794 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 867900000795 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 867900000796 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 867900000797 Glutaminase; Region: Glutaminase; cl00907 867900000798 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 867900000799 NAD(P) binding site [chemical binding]; other site 867900000800 active site 867900000801 Pterin 4 alpha carbinolamine dehydratase; Region: Pterin_4a; pfam01329 867900000802 DCoH dimer interaction site [polypeptide binding]; other site 867900000803 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 867900000804 DCoH tetramer interaction site [polypeptide binding]; other site 867900000805 substrate binding site [chemical binding]; other site 867900000806 aromatic arch; other site 867900000807 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 867900000808 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 867900000809 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 867900000810 active site 867900000811 putative catalytic site [active] 867900000812 DNA binding site [nucleotide binding] 867900000813 putative phosphate binding site [ion binding]; other site 867900000814 metal binding site A [ion binding]; metal-binding site 867900000815 AP binding site [nucleotide binding]; other site 867900000816 metal binding site B [ion binding]; metal-binding site 867900000817 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 867900000818 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 867900000819 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 867900000820 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 867900000821 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900000822 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 867900000823 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 867900000824 starch binding outer membrane protein SusD; Region: SusD; cd08977 867900000825 PKD domain; Region: PKD; pfam00801 867900000826 Alginate lyase; Region: Alginate_lyase2; pfam08787 867900000827 Transcriptional regulators [Transcription]; Region: FadR; COG2186 867900000828 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 867900000829 DNA-binding site [nucleotide binding]; DNA binding site 867900000830 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 867900000831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 867900000832 putative substrate translocation pore; other site 867900000833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 867900000834 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 867900000835 classical (c) SDRs; Region: SDR_c; cd05233 867900000836 NAD(P) binding site [chemical binding]; other site 867900000837 active site 867900000838 Domain of unknown function (DUF4294); Region: DUF4294; pfam14127 867900000839 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 867900000840 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 867900000841 oligomer interface [polypeptide binding]; other site 867900000842 active site 867900000843 metal binding site [ion binding]; metal-binding site 867900000844 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 867900000845 nudix motif; other site 867900000846 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 867900000847 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 867900000848 dimer interface [polypeptide binding]; other site 867900000849 motif 1; other site 867900000850 active site 867900000851 motif 2; other site 867900000852 motif 3; other site 867900000853 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 867900000854 anticodon binding site; other site 867900000855 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 867900000856 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 867900000857 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900000858 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 867900000859 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 867900000860 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 867900000861 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 867900000862 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 867900000863 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 867900000864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900000865 active site 867900000866 phosphorylation site [posttranslational modification] 867900000867 intermolecular recognition site; other site 867900000868 dimerization interface [polypeptide binding]; other site 867900000869 LytTr DNA-binding domain; Region: LytTR; smart00850 867900000870 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 867900000871 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 867900000872 ATP binding site [chemical binding]; other site 867900000873 putative Mg++ binding site [ion binding]; other site 867900000874 helicase superfamily c-terminal domain; Region: HELICc; smart00490 867900000875 nucleotide binding region [chemical binding]; other site 867900000876 ATP-binding site [chemical binding]; other site 867900000877 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 867900000878 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 867900000879 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 867900000880 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 867900000881 dimerization interface [polypeptide binding]; other site 867900000882 active site 867900000883 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 867900000884 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 867900000885 phosphoserine phosphatase SerB; Region: serB; TIGR00338 867900000886 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 867900000887 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 867900000888 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 867900000889 ligand binding site [chemical binding]; other site 867900000890 NAD binding site [chemical binding]; other site 867900000891 tetramer interface [polypeptide binding]; other site 867900000892 catalytic site [active] 867900000893 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 867900000894 L-serine binding site [chemical binding]; other site 867900000895 ACT domain interface; other site 867900000896 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 867900000897 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 867900000898 active site 867900000899 dimerization interface [polypeptide binding]; other site 867900000900 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 867900000901 helicase 45; Provisional; Region: PTZ00424 867900000902 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 867900000903 ATP binding site [chemical binding]; other site 867900000904 Mg++ binding site [ion binding]; other site 867900000905 motif III; other site 867900000906 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 867900000907 nucleotide binding region [chemical binding]; other site 867900000908 ATP-binding site [chemical binding]; other site 867900000909 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 867900000910 RNA binding site [nucleotide binding]; other site 867900000911 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900000912 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 867900000913 pentamer interface [polypeptide binding]; other site 867900000914 dodecaamer interface [polypeptide binding]; other site 867900000915 Response regulator receiver domain; Region: Response_reg; pfam00072 867900000916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900000917 active site 867900000918 phosphorylation site [posttranslational modification] 867900000919 intermolecular recognition site; other site 867900000920 dimerization interface [polypeptide binding]; other site 867900000921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 867900000922 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 867900000923 Walker A motif; other site 867900000924 ATP binding site [chemical binding]; other site 867900000925 Walker B motif; other site 867900000926 arginine finger; other site 867900000927 Mechanosensitive ion channel; Region: MS_channel; pfam00924 867900000928 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 867900000929 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 867900000930 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 867900000931 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 867900000932 Walker A/P-loop; other site 867900000933 ATP binding site [chemical binding]; other site 867900000934 Q-loop/lid; other site 867900000935 ABC transporter signature motif; other site 867900000936 Walker B; other site 867900000937 D-loop; other site 867900000938 H-loop/switch region; other site 867900000939 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 867900000940 chaperone protein DnaJ; Provisional; Region: PRK14289 867900000941 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 867900000942 HSP70 interaction site [polypeptide binding]; other site 867900000943 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 867900000944 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 867900000945 dimer interface [polypeptide binding]; other site 867900000946 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 867900000947 dimer interface [polypeptide binding]; other site 867900000948 GrpE; Region: GrpE; pfam01025 867900000949 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 867900000950 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 867900000951 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 867900000952 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 867900000953 homodimer interface [polypeptide binding]; other site 867900000954 substrate-cofactor binding pocket; other site 867900000955 catalytic residue [active] 867900000956 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 867900000957 metal binding site [ion binding]; metal-binding site 867900000958 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 867900000959 Nitrogen regulatory protein P-II; Region: P-II; smart00938 867900000960 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 867900000961 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 867900000962 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 867900000963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 867900000964 Major Facilitator Superfamily; Region: MFS_1; pfam07690 867900000965 putative substrate translocation pore; other site 867900000966 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 867900000967 DJ-1 family protein; Region: not_thiJ; TIGR01383 867900000968 conserved cys residue [active] 867900000969 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 867900000970 Mechanosensitive ion channel; Region: MS_channel; pfam00924 867900000971 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 867900000972 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 867900000973 dimerization interface [polypeptide binding]; other site 867900000974 putative Zn2+ binding site [ion binding]; other site 867900000975 putative DNA binding site [nucleotide binding]; other site 867900000976 AsnC family; Region: AsnC_trans_reg; pfam01037 867900000977 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 867900000978 B12 binding site [chemical binding]; other site 867900000979 cobalt ligand [ion binding]; other site 867900000980 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 867900000981 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 867900000982 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 867900000983 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 867900000984 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 867900000985 putative active site [active] 867900000986 putative substrate binding site [chemical binding]; other site 867900000987 putative cosubstrate binding site; other site 867900000988 catalytic site [active] 867900000989 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 867900000990 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 867900000991 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 867900000992 active site 867900000993 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 867900000994 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 867900000995 Beta-lactamase; Region: Beta-lactamase; pfam00144 867900000996 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_27; cd04686 867900000997 nudix motif; other site 867900000998 Predicted transcriptional regulators [Transcription]; Region: COG1733 867900000999 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 867900001000 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 867900001001 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 867900001002 active site 867900001003 metal binding site [ion binding]; metal-binding site 867900001004 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 867900001005 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 867900001006 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 867900001007 active site 867900001008 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 867900001009 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 867900001010 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 867900001011 Uncharacterized conserved protein [Function unknown]; Region: COG2128 867900001012 EthD domain; Region: EthD; cl17553 867900001013 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 867900001014 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 867900001015 catalytic residues [active] 867900001016 Major royal jelly protein; Region: MRJP; pfam03022 867900001017 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 867900001018 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 867900001019 motif II; other site 867900001020 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 867900001021 aspartate racemase; Region: asp_race; TIGR00035 867900001022 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 867900001023 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 867900001024 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 867900001025 dimerization interface [polypeptide binding]; other site 867900001026 putative DNA binding site [nucleotide binding]; other site 867900001027 putative Zn2+ binding site [ion binding]; other site 867900001028 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 867900001029 putative NAD(P) binding site [chemical binding]; other site 867900001030 homodimer interface [polypeptide binding]; other site 867900001031 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 867900001032 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 867900001033 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 867900001034 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 867900001035 active site 867900001036 dimer interface [polypeptide binding]; other site 867900001037 peptide chain release factor 1; Validated; Region: prfA; PRK00591 867900001038 This domain is found in peptide chain release factors; Region: PCRF; smart00937 867900001039 RF-1 domain; Region: RF-1; pfam00472 867900001040 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 867900001041 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 867900001042 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 867900001043 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 867900001044 ApbE family; Region: ApbE; pfam02424 867900001045 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 867900001046 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 867900001047 iron-sulfur cluster [ion binding]; other site 867900001048 [2Fe-2S] cluster binding site [ion binding]; other site 867900001049 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 867900001050 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 867900001051 dimerization interface [polypeptide binding]; other site 867900001052 ATP binding site [chemical binding]; other site 867900001053 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 867900001054 EamA-like transporter family; Region: EamA; pfam00892 867900001055 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 867900001056 Predicted permeases [General function prediction only]; Region: COG0795 867900001057 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 867900001058 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 867900001059 transketolase; Reviewed; Region: PRK05899 867900001060 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 867900001061 TPP-binding site [chemical binding]; other site 867900001062 dimer interface [polypeptide binding]; other site 867900001063 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 867900001064 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 867900001065 PYR/PP interface [polypeptide binding]; other site 867900001066 dimer interface [polypeptide binding]; other site 867900001067 TPP binding site [chemical binding]; other site 867900001068 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 867900001069 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 867900001070 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 867900001071 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 867900001072 RNA binding surface [nucleotide binding]; other site 867900001073 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 867900001074 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 867900001075 active site 867900001076 shikimate kinase; Reviewed; Region: aroK; PRK00131 867900001077 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 867900001078 ADP binding site [chemical binding]; other site 867900001079 magnesium binding site [ion binding]; other site 867900001080 putative shikimate binding site; other site 867900001081 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 867900001082 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 867900001083 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 867900001084 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 867900001085 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 867900001086 active site 867900001087 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 867900001088 Transcriptional regulator [Transcription]; Region: IclR; COG1414 867900001089 Bacterial transcriptional regulator; Region: IclR; pfam01614 867900001090 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 867900001091 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 867900001092 NAD(P) binding site [chemical binding]; other site 867900001093 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 867900001094 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 867900001095 NADP binding site [chemical binding]; other site 867900001096 homodimer interface [polypeptide binding]; other site 867900001097 active site 867900001098 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 867900001099 Sulfatase; Region: Sulfatase; pfam00884 867900001100 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 867900001101 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 867900001102 NAD binding site [chemical binding]; other site 867900001103 catalytic residues [active] 867900001104 substrate binding site [chemical binding]; other site 867900001105 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 867900001106 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 867900001107 active site pocket [active] 867900001108 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 867900001109 active site 867900001110 catalytic residues [active] 867900001111 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 867900001112 Domain of unknown function (DUF718); Region: DUF718; pfam05336 867900001113 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 867900001114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 867900001115 putative substrate translocation pore; other site 867900001116 short chain dehydrogenase; Provisional; Region: PRK08628 867900001117 classical (c) SDRs; Region: SDR_c; cd05233 867900001118 NAD(P) binding site [chemical binding]; other site 867900001119 active site 867900001120 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 867900001121 Amidohydrolase; Region: Amidohydro_2; pfam04909 867900001122 altronate oxidoreductase; Provisional; Region: PRK03643 867900001123 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 867900001124 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 867900001125 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 867900001126 galactarate dehydratase; Region: galactar-dH20; TIGR03248 867900001127 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 867900001128 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 867900001129 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 867900001130 putative NAD(P) binding site [chemical binding]; other site 867900001131 catalytic Zn binding site [ion binding]; other site 867900001132 structural Zn binding site [ion binding]; other site 867900001133 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 867900001134 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 867900001135 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 867900001136 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 867900001137 dimer interface [polypeptide binding]; other site 867900001138 phosphorylation site [posttranslational modification] 867900001139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900001140 ATP binding site [chemical binding]; other site 867900001141 Mg2+ binding site [ion binding]; other site 867900001142 G-X-G motif; other site 867900001143 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 867900001144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900001145 active site 867900001146 phosphorylation site [posttranslational modification] 867900001147 intermolecular recognition site; other site 867900001148 dimerization interface [polypeptide binding]; other site 867900001149 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 867900001150 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 867900001151 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 867900001152 Sulfatase; Region: Sulfatase; cl17466 867900001153 Sulfatase; Region: Sulfatase; cl17466 867900001154 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 867900001155 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 867900001156 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 867900001157 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 867900001158 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 867900001159 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 867900001160 Sulfatase; Region: Sulfatase; pfam00884 867900001161 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 867900001162 Sulfatase; Region: Sulfatase; pfam00884 867900001163 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 867900001164 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 867900001165 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 867900001166 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 867900001167 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 867900001168 Sulfatase; Region: Sulfatase; pfam00884 867900001169 Sulfatase; Region: Sulfatase; cl17466 867900001170 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 867900001171 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 867900001172 active site 867900001173 catalytic residues [active] 867900001174 Sulfatase; Region: Sulfatase; cl17466 867900001175 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 867900001176 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 867900001177 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 867900001178 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 867900001179 Sulfatase; Region: Sulfatase; pfam00884 867900001180 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 867900001181 active site 867900001182 catalytic residues [active] 867900001183 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 867900001184 active site 867900001185 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 867900001186 Sulfatase; Region: Sulfatase; pfam00884 867900001187 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 867900001188 substrate binding site [chemical binding]; other site 867900001189 active site 867900001190 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 867900001191 metal binding site [ion binding]; metal-binding site 867900001192 ligand binding site [chemical binding]; other site 867900001193 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 867900001194 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 867900001195 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 867900001196 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 867900001197 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 867900001198 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 867900001199 Sulfatase; Region: Sulfatase; cl17466 867900001200 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 867900001201 Beta-agarase, member of glycosyl hydrolase family 16; Region: GH16_beta_agarase; cd02178 867900001202 calcium binding site [ion binding]; other site 867900001203 active site 867900001204 catalytic residues [active] 867900001205 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 867900001206 starch binding outer membrane protein SusD; Region: SusD; cl17845 867900001207 SusD family; Region: SusD; pfam07980 867900001208 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 867900001209 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900001210 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 867900001211 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900001212 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 867900001213 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 867900001214 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 867900001215 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 867900001216 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 867900001217 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 867900001218 Protein of unknown function (DUF2540); Region: DUF2540; pfam10802 867900001219 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 867900001220 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 867900001221 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 867900001222 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 867900001223 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 867900001224 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 867900001225 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 867900001226 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 867900001227 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 867900001228 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 867900001229 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 867900001230 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 867900001231 DNA binding residues [nucleotide binding] 867900001232 B12 binding domain; Region: B12-binding_2; pfam02607 867900001233 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 867900001234 Fasciclin domain; Region: Fasciclin; pfam02469 867900001235 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 867900001236 Fasciclin domain; Region: Fasciclin; pfam02469 867900001237 Fasciclin domain; Region: Fasciclin; pfam02469 867900001238 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 867900001239 Fasciclin domain; Region: Fasciclin; pfam02469 867900001240 phytoene desaturase; Region: crtI_fam; TIGR02734 867900001241 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 867900001242 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 867900001243 active site lid residues [active] 867900001244 substrate binding pocket [chemical binding]; other site 867900001245 catalytic residues [active] 867900001246 substrate-Mg2+ binding site; other site 867900001247 aspartate-rich region 1; other site 867900001248 aspartate-rich region 2; other site 867900001249 beta-carotene hydroxylase; Region: PLN02601 867900001250 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 867900001251 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 867900001252 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 867900001253 DNA photolyase; Region: DNA_photolyase; pfam00875 867900001254 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 867900001255 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 867900001256 catalytic residues [active] 867900001257 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 867900001258 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 867900001259 catalytic residues [active] 867900001260 aconitate hydratase; Validated; Region: PRK07229 867900001261 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Mitochondrial; cd01584 867900001262 substrate binding site [chemical binding]; other site 867900001263 ligand binding site [chemical binding]; other site 867900001264 Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes...; Region: AcnA_Mitochon_Swivel; cd01578 867900001265 substrate binding site [chemical binding]; other site 867900001266 MoxR-like ATPases [General function prediction only]; Region: COG0714 867900001267 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 867900001268 Walker A motif; other site 867900001269 ATP binding site [chemical binding]; other site 867900001270 Walker B motif; other site 867900001271 arginine finger; other site 867900001272 SurA N-terminal domain; Region: SurA_N; pfam09312 867900001273 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 867900001274 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 867900001275 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 867900001276 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 867900001277 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 867900001278 amphipathic channel; other site 867900001279 Asn-Pro-Ala signature motifs; other site 867900001280 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 867900001281 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 867900001282 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 867900001283 Beta-lactamase; Region: Beta-lactamase; pfam00144 867900001284 amidase; Provisional; Region: PRK06707 867900001285 Amidase; Region: Amidase; cl11426 867900001286 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 867900001287 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 867900001288 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 867900001289 Domain of unknown function (DUF4295); Region: DUF4295; pfam14128 867900001290 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 867900001291 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 867900001292 competence damage-inducible protein A; Provisional; Region: PRK00549 867900001293 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 867900001294 putative MPT binding site; other site 867900001295 Competence-damaged protein; Region: CinA; pfam02464 867900001296 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 867900001297 putative binding surface; other site 867900001298 active site 867900001299 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 867900001300 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 867900001301 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900001302 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 867900001303 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 867900001304 active site 867900001305 catalytic site [active] 867900001306 substrate binding site [chemical binding]; other site 867900001307 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 867900001308 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 867900001309 E3 interaction surface; other site 867900001310 lipoyl attachment site [posttranslational modification]; other site 867900001311 e3 binding domain; Region: E3_binding; pfam02817 867900001312 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 867900001313 recombination protein RecR; Reviewed; Region: recR; PRK00076 867900001314 RecR protein; Region: RecR; pfam02132 867900001315 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 867900001316 putative active site [active] 867900001317 putative metal-binding site [ion binding]; other site 867900001318 tetramer interface [polypeptide binding]; other site 867900001319 Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326 867900001320 Na binding site [ion binding]; other site 867900001321 CoA binding domain; Region: CoA_binding_2; pfam13380 867900001322 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 867900001323 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 867900001324 dimer interface [polypeptide binding]; other site 867900001325 active site 867900001326 CoA binding pocket [chemical binding]; other site 867900001327 heat shock protein 90; Provisional; Region: PRK05218 867900001328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900001329 ATP binding site [chemical binding]; other site 867900001330 Mg2+ binding site [ion binding]; other site 867900001331 G-X-G motif; other site 867900001332 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 867900001333 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 867900001334 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 867900001335 DNA binding residues [nucleotide binding] 867900001336 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 867900001337 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 867900001338 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 867900001339 DNA binding residues [nucleotide binding] 867900001340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 867900001341 MOSC domain; Region: MOSC; pfam03473 867900001342 Cupin domain; Region: Cupin_2; pfam07883 867900001343 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 867900001344 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 867900001345 active site 867900001346 Zn binding site [ion binding]; other site 867900001347 Transglycosylase; Region: Transgly; pfam00912 867900001348 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 867900001349 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 867900001350 PGAP1-like protein; Region: PGAP1; pfam07819 867900001351 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 867900001352 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 867900001353 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 867900001354 active site 867900001355 motif I; other site 867900001356 motif II; other site 867900001357 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 867900001358 Protein of unknown function (DUF819); Region: DUF819; cl02317 867900001359 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 867900001360 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 867900001361 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cd12213 867900001362 ligand binding site [chemical binding]; other site 867900001363 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 867900001364 active site 867900001365 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 867900001366 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 867900001367 active site 867900001368 metal binding site [ion binding]; metal-binding site 867900001369 nudix motif; other site 867900001370 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 867900001371 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 867900001372 Calx-beta domain; Region: Calx-beta; pfam03160 867900001373 CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041 867900001374 heterodimerization interface [polypeptide binding]; other site 867900001375 Calx-beta domain; Region: Calx-beta; pfam03160 867900001376 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 867900001377 Right handed beta helix region; Region: Beta_helix; pfam13229 867900001378 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 867900001379 binding surface 867900001380 TPR motif; other site 867900001381 Tetratricopeptide repeat; Region: TPR_16; pfam13432 867900001382 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 867900001383 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 867900001384 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 867900001385 ligand binding site [chemical binding]; other site 867900001386 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 867900001387 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 867900001388 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 867900001389 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 867900001390 G1 box; other site 867900001391 putative GEF interaction site [polypeptide binding]; other site 867900001392 GTP/Mg2+ binding site [chemical binding]; other site 867900001393 Switch I region; other site 867900001394 G2 box; other site 867900001395 G3 box; other site 867900001396 Switch II region; other site 867900001397 G4 box; other site 867900001398 G5 box; other site 867900001399 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 867900001400 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 867900001401 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 867900001402 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 867900001403 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 867900001404 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 867900001405 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 867900001406 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 867900001407 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 867900001408 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 867900001409 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 867900001410 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 867900001411 DNA binding site [nucleotide binding] 867900001412 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 867900001413 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 867900001414 DNA-directed RNA polymerase subunit B''; Validated; Region: PRK09606 867900001415 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 867900001416 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 867900001417 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 867900001418 RPB12 interaction site [polypeptide binding]; other site 867900001419 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 867900001420 RPB3 interaction site [polypeptide binding]; other site 867900001421 RPB1 interaction site [polypeptide binding]; other site 867900001422 RPB11 interaction site [polypeptide binding]; other site 867900001423 RPB10 interaction site [polypeptide binding]; other site 867900001424 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 867900001425 core dimer interface [polypeptide binding]; other site 867900001426 peripheral dimer interface [polypeptide binding]; other site 867900001427 L10 interface [polypeptide binding]; other site 867900001428 L11 interface [polypeptide binding]; other site 867900001429 putative EF-Tu interaction site [polypeptide binding]; other site 867900001430 putative EF-G interaction site [polypeptide binding]; other site 867900001431 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 867900001432 23S rRNA interface [nucleotide binding]; other site 867900001433 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 867900001434 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 867900001435 mRNA/rRNA interface [nucleotide binding]; other site 867900001436 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 867900001437 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 867900001438 23S rRNA interface [nucleotide binding]; other site 867900001439 L7/L12 interface [polypeptide binding]; other site 867900001440 putative thiostrepton binding site; other site 867900001441 L25 interface [polypeptide binding]; other site 867900001442 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 867900001443 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 867900001444 putative homodimer interface [polypeptide binding]; other site 867900001445 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 867900001446 heterodimer interface [polypeptide binding]; other site 867900001447 homodimer interface [polypeptide binding]; other site 867900001448 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 867900001449 elongation factor Tu; Reviewed; Region: PRK12735 867900001450 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 867900001451 G1 box; other site 867900001452 GEF interaction site [polypeptide binding]; other site 867900001453 GTP/Mg2+ binding site [chemical binding]; other site 867900001454 Switch I region; other site 867900001455 G2 box; other site 867900001456 G3 box; other site 867900001457 Switch II region; other site 867900001458 G4 box; other site 867900001459 G5 box; other site 867900001460 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 867900001461 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 867900001462 Antibiotic Binding Site [chemical binding]; other site 867900001463 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 867900001464 30S subunit binding site; other site 867900001465 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 867900001466 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 867900001467 active site 867900001468 DNA binding site [nucleotide binding] 867900001469 Int/Topo IB signature motif; other site 867900001470 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 867900001471 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 867900001472 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 867900001473 active site 867900001474 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 867900001475 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 867900001476 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 867900001477 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 867900001478 lipoyl-biotinyl attachment site [posttranslational modification]; other site 867900001479 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 867900001480 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 867900001481 Ion channel; Region: Ion_trans_2; pfam07885 867900001482 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 867900001483 TrkA-N domain; Region: TrkA_N; pfam02254 867900001484 TrkA-C domain; Region: TrkA_C; pfam02080 867900001485 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 867900001486 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 867900001487 active site residue [active] 867900001488 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 867900001489 MarR family; Region: MarR_2; cl17246 867900001490 YceI-like domain; Region: YceI; pfam04264 867900001491 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 867900001492 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 867900001493 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 867900001494 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 867900001495 Glutamine amidotransferase class-I; Region: GATase; pfam00117 867900001496 glutamine binding [chemical binding]; other site 867900001497 catalytic triad [active] 867900001498 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 867900001499 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 867900001500 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 867900001501 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 867900001502 active site 867900001503 ribulose/triose binding site [chemical binding]; other site 867900001504 phosphate binding site [ion binding]; other site 867900001505 substrate (anthranilate) binding pocket [chemical binding]; other site 867900001506 product (indole) binding pocket [chemical binding]; other site 867900001507 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 867900001508 active site 867900001509 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 867900001510 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 867900001511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 867900001512 catalytic residue [active] 867900001513 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 867900001514 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 867900001515 substrate binding site [chemical binding]; other site 867900001516 active site 867900001517 catalytic residues [active] 867900001518 heterodimer interface [polypeptide binding]; other site 867900001519 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 867900001520 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 867900001521 active site 867900001522 catalytic site [active] 867900001523 Esterase/lipase [General function prediction only]; Region: COG1647 867900001524 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900001525 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 867900001526 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 867900001527 N-terminal plug; other site 867900001528 ligand-binding site [chemical binding]; other site 867900001529 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 867900001530 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 867900001531 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 867900001532 ABC transporter; Region: ABC_tran_2; pfam12848 867900001533 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 867900001534 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 867900001535 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 867900001536 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 867900001537 N-terminal plug; other site 867900001538 ligand-binding site [chemical binding]; other site 867900001539 pyruvate carboxylase; Reviewed; Region: PRK12999 867900001540 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 867900001541 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 867900001542 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 867900001543 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 867900001544 active site 867900001545 catalytic residues [active] 867900001546 metal binding site [ion binding]; metal-binding site 867900001547 homodimer binding site [polypeptide binding]; other site 867900001548 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 867900001549 carboxyltransferase (CT) interaction site; other site 867900001550 biotinylation site [posttranslational modification]; other site 867900001551 hypothetical protein; Validated; Region: PRK02101 867900001552 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 867900001553 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 867900001554 RNA binding surface [nucleotide binding]; other site 867900001555 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 867900001556 active site 867900001557 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 867900001558 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 867900001559 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 867900001560 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 867900001561 ATP-grasp domain; Region: ATP-grasp_4; cl17255 867900001562 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 867900001563 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 867900001564 active site 867900001565 (T/H)XGH motif; other site 867900001566 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 867900001567 putative active site [active] 867900001568 Zn binding site [ion binding]; other site 867900001569 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 867900001570 active site 867900001571 Ap6A binding site [chemical binding]; other site 867900001572 nudix motif; other site 867900001573 metal binding site [ion binding]; metal-binding site 867900001574 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 867900001575 active site 867900001576 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 867900001577 hydrophobic ligand binding site; other site 867900001578 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 867900001579 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 867900001580 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 867900001581 FtsH Extracellular; Region: FtsH_ext; pfam06480 867900001582 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 867900001583 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 867900001584 Walker A motif; other site 867900001585 ATP binding site [chemical binding]; other site 867900001586 Walker B motif; other site 867900001587 arginine finger; other site 867900001588 Peptidase family M41; Region: Peptidase_M41; pfam01434 867900001589 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 867900001590 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 867900001591 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 867900001592 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 867900001593 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 867900001594 acyl-CoA binding pocket [chemical binding]; other site 867900001595 CoA binding site [chemical binding]; other site 867900001596 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 867900001597 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 867900001598 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 867900001599 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 867900001600 active site 867900001601 HIGH motif; other site 867900001602 nucleotide binding site [chemical binding]; other site 867900001603 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 867900001604 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 867900001605 active site 867900001606 KMSKS motif; other site 867900001607 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 867900001608 tRNA binding surface [nucleotide binding]; other site 867900001609 anticodon binding site; other site 867900001610 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 867900001611 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 867900001612 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 867900001613 catalytic motif [active] 867900001614 Catalytic residue [active] 867900001615 Aspartyl protease; Region: Asp_protease_2; pfam13650 867900001616 inhibitor binding site; inhibition site 867900001617 catalytic motif [active] 867900001618 Catalytic residue [active] 867900001619 Active site flap [active] 867900001620 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 867900001621 aspartate aminotransferase; Provisional; Region: PRK07568 867900001622 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 867900001623 pyridoxal 5'-phosphate binding site [chemical binding]; other site 867900001624 homodimer interface [polypeptide binding]; other site 867900001625 catalytic residue [active] 867900001626 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 867900001627 FAD binding domain; Region: FAD_binding_4; pfam01565 867900001628 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 867900001629 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 867900001630 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 867900001631 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 867900001632 DNA binding residues [nucleotide binding] 867900001633 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 867900001634 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 867900001635 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 867900001636 DNA binding residues [nucleotide binding] 867900001637 lipoyl synthase; Provisional; Region: PRK05481 867900001638 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 867900001639 FeS/SAM binding site; other site 867900001640 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 867900001641 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 867900001642 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 867900001643 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 867900001644 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 867900001645 dimer interface [polypeptide binding]; other site 867900001646 phosphorylation site [posttranslational modification] 867900001647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900001648 ATP binding site [chemical binding]; other site 867900001649 Mg2+ binding site [ion binding]; other site 867900001650 G-X-G motif; other site 867900001651 Response regulator receiver domain; Region: Response_reg; pfam00072 867900001652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900001653 active site 867900001654 phosphorylation site [posttranslational modification] 867900001655 intermolecular recognition site; other site 867900001656 dimerization interface [polypeptide binding]; other site 867900001657 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 867900001658 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 867900001659 Uncharacterized conserved protein [Function unknown]; Region: COG0327 867900001660 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 867900001661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 867900001662 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 867900001663 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 867900001664 Putative zinc ribbon domain; Region: DUF164; pfam02591 867900001665 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 867900001666 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 867900001667 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 867900001668 Clp protease; Region: CLP_protease; pfam00574 867900001669 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 867900001670 oligomer interface [polypeptide binding]; other site 867900001671 active site residues [active] 867900001672 kynureninase; Region: kynureninase; TIGR01814 867900001673 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 867900001674 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 867900001675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 867900001676 S-adenosylmethionine binding site [chemical binding]; other site 867900001677 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 867900001678 active site 867900001679 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 867900001680 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 867900001681 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 867900001682 Zn binding site [ion binding]; other site 867900001683 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900001684 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900001685 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900001686 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900001687 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900001688 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 867900001689 active site pocket [active] 867900001690 oxyanion hole [active] 867900001691 catalytic triad [active] 867900001692 active site nucleophile [active] 867900001693 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 867900001694 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 867900001695 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 867900001696 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 867900001697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 867900001698 Coenzyme A binding pocket [chemical binding]; other site 867900001699 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 867900001700 Peptidase family M48; Region: Peptidase_M48; pfam01435 867900001701 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 867900001702 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 867900001703 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 867900001704 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 867900001705 phosphoglyceromutase; Provisional; Region: PRK05434 867900001706 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 867900001707 active site 867900001708 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 867900001709 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 867900001710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 867900001711 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 867900001712 ApbE family; Region: ApbE; pfam02424 867900001713 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 867900001714 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 867900001715 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 867900001716 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 867900001717 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 867900001718 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 867900001719 catalytic loop [active] 867900001720 iron binding site [ion binding]; other site 867900001721 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 867900001722 FAD binding pocket [chemical binding]; other site 867900001723 FAD binding motif [chemical binding]; other site 867900001724 phosphate binding motif [ion binding]; other site 867900001725 beta-alpha-beta structure motif; other site 867900001726 NAD binding pocket [chemical binding]; other site 867900001727 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 867900001728 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 867900001729 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 867900001730 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 867900001731 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 867900001732 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 867900001733 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 867900001734 lipoyl-biotinyl attachment site [posttranslational modification]; other site 867900001735 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 867900001736 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 867900001737 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 867900001738 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 867900001739 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 867900001740 Glutamate binding site [chemical binding]; other site 867900001741 NAD binding site [chemical binding]; other site 867900001742 catalytic residues [active] 867900001743 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 867900001744 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 867900001745 Fatty acid desaturase; Region: FA_desaturase; pfam00487 867900001746 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 867900001747 putative di-iron ligands [ion binding]; other site 867900001748 aspartate aminotransferase; Provisional; Region: PRK05764 867900001749 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 867900001750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 867900001751 homodimer interface [polypeptide binding]; other site 867900001752 catalytic residue [active] 867900001753 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 867900001754 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 867900001755 active site 867900001756 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 867900001757 YhhN-like protein; Region: YhhN; pfam07947 867900001758 Protein of unknown function, DUF399; Region: DUF399; pfam04187 867900001759 SnoaL-like domain; Region: SnoaL_2; pfam12680 867900001760 Cation transport protein; Region: TrkH; cl17365 867900001761 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 867900001762 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 867900001763 TrkA-N domain; Region: TrkA_N; pfam02254 867900001764 TrkA-C domain; Region: TrkA_C; pfam02080 867900001765 TrkA-N domain; Region: TrkA_N; pfam02254 867900001766 TrkA-C domain; Region: TrkA_C; pfam02080 867900001767 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 867900001768 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 867900001769 S-adenosylmethionine binding site [chemical binding]; other site 867900001770 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 867900001771 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 867900001772 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 867900001773 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 867900001774 Surface antigen; Region: Bac_surface_Ag; pfam01103 867900001775 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 867900001776 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 867900001777 active site 867900001778 intersubunit interface [polypeptide binding]; other site 867900001779 zinc binding site [ion binding]; other site 867900001780 Na+ binding site [ion binding]; other site 867900001781 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 867900001782 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 867900001783 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 867900001784 16S/18S rRNA binding site [nucleotide binding]; other site 867900001785 S13e-L30e interaction site [polypeptide binding]; other site 867900001786 25S rRNA binding site [nucleotide binding]; other site 867900001787 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 867900001788 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 867900001789 RNase E interface [polypeptide binding]; other site 867900001790 trimer interface [polypeptide binding]; other site 867900001791 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 867900001792 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 867900001793 RNase E interface [polypeptide binding]; other site 867900001794 trimer interface [polypeptide binding]; other site 867900001795 active site 867900001796 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 867900001797 putative nucleic acid binding region [nucleotide binding]; other site 867900001798 G-X-X-G motif; other site 867900001799 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 867900001800 RNA binding site [nucleotide binding]; other site 867900001801 domain interface; other site 867900001802 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 867900001803 metal ion-dependent adhesion site (MIDAS); other site 867900001804 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 867900001805 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 867900001806 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 867900001807 nucleotide binding site [chemical binding]; other site 867900001808 homotetrameric interface [polypeptide binding]; other site 867900001809 putative phosphate binding site [ion binding]; other site 867900001810 putative allosteric binding site; other site 867900001811 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 867900001812 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 867900001813 putative catalytic cysteine [active] 867900001814 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 867900001815 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 867900001816 DXD motif; other site 867900001817 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 867900001818 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 867900001819 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 867900001820 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 867900001821 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 867900001822 DNA binding residues [nucleotide binding] 867900001823 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 867900001824 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 867900001825 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 867900001826 SusD family; Region: SusD; pfam07980 867900001827 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 867900001828 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 867900001829 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 867900001830 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900001831 starch binding outer membrane protein SusD; Region: SusD; cl17845 867900001832 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 867900001833 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900001834 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 867900001835 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900001836 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 867900001837 starch binding outer membrane protein SusD; Region: SusD; cd08977 867900001838 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 867900001839 starch binding outer membrane protein SusD; Region: SusD; cl17845 867900001840 SusD family; Region: SusD; pfam07980 867900001841 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 867900001842 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900001843 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 867900001844 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900001845 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 867900001846 RNA/DNA hybrid binding site [nucleotide binding]; other site 867900001847 active site 867900001848 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 867900001849 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 867900001850 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 867900001851 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 867900001852 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 867900001853 dimer interface [polypeptide binding]; other site 867900001854 putative anticodon binding site; other site 867900001855 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 867900001856 motif 1; other site 867900001857 active site 867900001858 motif 2; other site 867900001859 motif 3; other site 867900001860 Predicted membrane protein [Function unknown]; Region: COG4682 867900001861 yiaA/B two helix domain; Region: YiaAB; pfam05360 867900001862 yiaA/B two helix domain; Region: YiaAB; pfam05360 867900001863 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 867900001864 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 867900001865 transmembrane helices; other site 867900001866 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 867900001867 active site 867900001868 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 867900001869 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 867900001870 inhibitor-cofactor binding pocket; inhibition site 867900001871 pyridoxal 5'-phosphate binding site [chemical binding]; other site 867900001872 catalytic residue [active] 867900001873 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 867900001874 LysM domain; Region: LysM; pfam01476 867900001875 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 867900001876 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 867900001877 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 867900001878 catalytic residue [active] 867900001879 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 867900001880 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 867900001881 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 867900001882 cofactor binding site; other site 867900001883 metal binding site [ion binding]; metal-binding site 867900001884 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 867900001885 GSCFA family; Region: GSCFA; pfam08885 867900001886 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 867900001887 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 867900001888 motif 1; other site 867900001889 active site 867900001890 motif 2; other site 867900001891 motif 3; other site 867900001892 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 867900001893 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 867900001894 Peptidase family M23; Region: Peptidase_M23; pfam01551 867900001895 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 867900001896 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 867900001897 DNA binding residues [nucleotide binding] 867900001898 LemA family; Region: LemA; cl00742 867900001899 Repair protein; Region: Repair_PSII; pfam04536 867900001900 Repair protein; Region: Repair_PSII; pfam04536 867900001901 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900001902 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 867900001903 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900001904 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 867900001905 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 867900001906 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 867900001907 Na binding site [ion binding]; other site 867900001908 Trehalase; Region: Trehalase; cl17346 867900001909 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900001910 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 867900001911 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900001912 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900001913 Transcriptional regulators [Transcription]; Region: PurR; COG1609 867900001914 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 867900001915 DNA binding site [nucleotide binding] 867900001916 domain linker motif; other site 867900001917 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 867900001918 dimerization interface [polypeptide binding]; other site 867900001919 ligand binding site [chemical binding]; other site 867900001920 GTP-binding protein Der; Reviewed; Region: PRK00093 867900001921 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 867900001922 G1 box; other site 867900001923 GTP/Mg2+ binding site [chemical binding]; other site 867900001924 Switch I region; other site 867900001925 G2 box; other site 867900001926 Switch II region; other site 867900001927 G3 box; other site 867900001928 G4 box; other site 867900001929 G5 box; other site 867900001930 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 867900001931 G1 box; other site 867900001932 GTP/Mg2+ binding site [chemical binding]; other site 867900001933 Switch I region; other site 867900001934 G2 box; other site 867900001935 G3 box; other site 867900001936 Switch II region; other site 867900001937 G4 box; other site 867900001938 G5 box; other site 867900001939 Uncharacterized conserved protein [Function unknown]; Region: COG3391 867900001940 Biotin synthase-related enzyme [General function prediction only]; Region: COG2516 867900001941 GTPase Era; Reviewed; Region: era; PRK00089 867900001942 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 867900001943 G1 box; other site 867900001944 GTP/Mg2+ binding site [chemical binding]; other site 867900001945 Switch I region; other site 867900001946 G2 box; other site 867900001947 Switch II region; other site 867900001948 G3 box; other site 867900001949 G4 box; other site 867900001950 G5 box; other site 867900001951 KH domain; Region: KH_2; pfam07650 867900001952 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 867900001953 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 867900001954 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 867900001955 ligand binding site [chemical binding]; other site 867900001956 flexible hinge region; other site 867900001957 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 867900001958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 867900001959 putative substrate translocation pore; other site 867900001960 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 867900001961 PQQ-like domain; Region: PQQ_2; pfam13360 867900001962 Trp docking motif [polypeptide binding]; other site 867900001963 active site 867900001964 short chain dehydrogenase; Provisional; Region: PRK07326 867900001965 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 867900001966 NAD(P) binding site [chemical binding]; other site 867900001967 active site 867900001968 CARDB; Region: CARDB; pfam07705 867900001969 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 867900001970 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 867900001971 Histidine kinase; Region: His_kinase; pfam06580 867900001972 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 867900001973 Mg2+ binding site [ion binding]; other site 867900001974 G-X-G motif; other site 867900001975 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 867900001976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900001977 active site 867900001978 phosphorylation site [posttranslational modification] 867900001979 intermolecular recognition site; other site 867900001980 dimerization interface [polypeptide binding]; other site 867900001981 LytTr DNA-binding domain; Region: LytTR; smart00850 867900001982 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 867900001983 Domain of unknown function (DUF336); Region: DUF336; pfam03928 867900001984 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 867900001985 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 867900001986 ligand binding site [chemical binding]; other site 867900001987 flexible hinge region; other site 867900001988 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 867900001989 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 867900001990 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 867900001991 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 867900001992 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 867900001993 Protein of unknown function (DUF2452); Region: DUF2452; pfam10504 867900001994 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 867900001995 Rubredoxin; Region: Rubredoxin; pfam00301 867900001996 iron binding site [ion binding]; other site 867900001997 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 867900001998 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 867900001999 molybdopterin cofactor binding site; other site 867900002000 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 867900002001 molybdopterin cofactor binding site; other site 867900002002 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 867900002003 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 867900002004 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 867900002005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900002006 active site 867900002007 phosphorylation site [posttranslational modification] 867900002008 intermolecular recognition site; other site 867900002009 dimerization interface [polypeptide binding]; other site 867900002010 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 867900002011 DNA binding residues [nucleotide binding] 867900002012 dimerization interface [polypeptide binding]; other site 867900002013 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 867900002014 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 867900002015 Walker A/P-loop; other site 867900002016 ATP binding site [chemical binding]; other site 867900002017 Q-loop/lid; other site 867900002018 ABC transporter signature motif; other site 867900002019 Walker B; other site 867900002020 D-loop; other site 867900002021 H-loop/switch region; other site 867900002022 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 867900002023 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 867900002024 Walker A/P-loop; other site 867900002025 ATP binding site [chemical binding]; other site 867900002026 Q-loop/lid; other site 867900002027 ABC transporter signature motif; other site 867900002028 Walker B; other site 867900002029 D-loop; other site 867900002030 H-loop/switch region; other site 867900002031 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 867900002032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 867900002033 dimer interface [polypeptide binding]; other site 867900002034 conserved gate region; other site 867900002035 putative PBP binding loops; other site 867900002036 ABC-ATPase subunit interface; other site 867900002037 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 867900002038 NMT1-like family; Region: NMT1_2; pfam13379 867900002039 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 867900002040 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 867900002041 ligand binding site [chemical binding]; other site 867900002042 flexible hinge region; other site 867900002043 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 867900002044 putative switch regulator; other site 867900002045 non-specific DNA interactions [nucleotide binding]; other site 867900002046 DNA binding site [nucleotide binding] 867900002047 sequence specific DNA binding site [nucleotide binding]; other site 867900002048 putative cAMP binding site [chemical binding]; other site 867900002049 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 867900002050 active site 867900002051 SAM binding site [chemical binding]; other site 867900002052 homodimer interface [polypeptide binding]; other site 867900002053 nitrite reductase subunit NirD; Provisional; Region: PRK14989 867900002054 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 867900002055 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 867900002056 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 867900002057 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 867900002058 Domain of unknown function (DUF4202); Region: DUF4202; pfam13875 867900002059 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 867900002060 PAS domain; Region: PAS_9; pfam13426 867900002061 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 867900002062 Histidine kinase; Region: HisKA_3; pfam07730 867900002063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900002064 ATP binding site [chemical binding]; other site 867900002065 Mg2+ binding site [ion binding]; other site 867900002066 G-X-G motif; other site 867900002067 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 867900002068 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 867900002069 putative active site [active] 867900002070 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 867900002071 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 867900002072 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 867900002073 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 867900002074 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900002075 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 867900002076 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900002077 SusD family; Region: SusD; pfam07980 867900002078 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 867900002079 Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326 867900002080 Na binding site [ion binding]; other site 867900002081 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 867900002082 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 867900002083 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 867900002084 Beta-lactamase; Region: Beta-lactamase; cl17358 867900002085 Leucine rich repeat; Region: LRR_8; pfam13855 867900002086 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 867900002087 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 867900002088 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 867900002089 ABC transporter; Region: ABC_tran_2; pfam12848 867900002090 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 867900002091 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 867900002092 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 867900002093 gliding motility associated protien GldN; Region: GldN; TIGR03523 867900002094 gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517 867900002095 GldM N-terminal domain; Region: GldM_N; pfam12081 867900002096 GldM C-terminal domain; Region: GldM_C; pfam12080 867900002097 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 867900002098 gliding motility-associated lipoprotein GldK; Region: GldK; TIGR03525 867900002099 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 867900002100 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 867900002101 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 867900002102 putative active site [active] 867900002103 putative metal binding site [ion binding]; other site 867900002104 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 867900002105 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 867900002106 active site 867900002107 interdomain interaction site; other site 867900002108 putative metal-binding site [ion binding]; other site 867900002109 nucleotide binding site [chemical binding]; other site 867900002110 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 867900002111 domain I; other site 867900002112 DNA binding groove [nucleotide binding] 867900002113 phosphate binding site [ion binding]; other site 867900002114 domain II; other site 867900002115 domain III; other site 867900002116 nucleotide binding site [chemical binding]; other site 867900002117 catalytic site [active] 867900002118 domain IV; other site 867900002119 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 867900002120 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 867900002121 Uncharacterized conserved protein [Function unknown]; Region: COG5276 867900002122 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 867900002123 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 867900002124 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 867900002125 FeS/SAM binding site; other site 867900002126 TRAM domain; Region: TRAM; pfam01938 867900002127 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 867900002128 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 867900002129 Walker A motif; other site 867900002130 ATP binding site [chemical binding]; other site 867900002131 Walker B motif; other site 867900002132 arginine finger; other site 867900002133 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 867900002134 Lipopolysaccharide-assembly; Region: LptE; pfam04390 867900002135 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 867900002136 oligomerisation interface [polypeptide binding]; other site 867900002137 mobile loop; other site 867900002138 roof hairpin; other site 867900002139 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 867900002140 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 867900002141 ring oligomerisation interface [polypeptide binding]; other site 867900002142 ATP/Mg binding site [chemical binding]; other site 867900002143 stacking interactions; other site 867900002144 hinge regions; other site 867900002145 Heavy-metal-associated domain; Region: HMA; pfam00403 867900002146 metal-binding site [ion binding] 867900002147 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900002148 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 867900002149 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900002150 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 867900002151 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 867900002152 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 867900002153 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 867900002154 purine monophosphate binding site [chemical binding]; other site 867900002155 dimer interface [polypeptide binding]; other site 867900002156 putative catalytic residues [active] 867900002157 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 867900002158 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 867900002159 rod shape-determining protein MreB; Provisional; Region: PRK13927 867900002160 MreB and similar proteins; Region: MreB_like; cd10225 867900002161 nucleotide binding site [chemical binding]; other site 867900002162 Mg binding site [ion binding]; other site 867900002163 putative protofilament interaction site [polypeptide binding]; other site 867900002164 RodZ interaction site [polypeptide binding]; other site 867900002165 rod shape-determining protein MreC; Provisional; Region: PRK13922 867900002166 rod shape-determining protein MreC; Region: MreC; pfam04085 867900002167 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 867900002168 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 867900002169 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 867900002170 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 867900002171 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 867900002172 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 867900002173 active site 867900002174 substrate binding site [chemical binding]; other site 867900002175 Mg2+ binding site [ion binding]; other site 867900002176 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 867900002177 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 867900002178 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 867900002179 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 867900002180 protein binding site [polypeptide binding]; other site 867900002181 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 867900002182 Catalytic dyad [active] 867900002183 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 867900002184 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 867900002185 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 867900002186 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 867900002187 NlpC/P60 family; Region: NLPC_P60; pfam00877 867900002188 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 867900002189 Competence protein; Region: Competence; pfam03772 867900002190 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 867900002191 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 867900002192 DNA-binding site [nucleotide binding]; DNA binding site 867900002193 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 867900002194 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 867900002195 glycerol kinase; Provisional; Region: glpK; PRK00047 867900002196 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 867900002197 N- and C-terminal domain interface [polypeptide binding]; other site 867900002198 active site 867900002199 MgATP binding site [chemical binding]; other site 867900002200 catalytic site [active] 867900002201 metal binding site [ion binding]; metal-binding site 867900002202 glycerol binding site [chemical binding]; other site 867900002203 homotetramer interface [polypeptide binding]; other site 867900002204 homodimer interface [polypeptide binding]; other site 867900002205 FBP binding site [chemical binding]; other site 867900002206 protein IIAGlc interface [polypeptide binding]; other site 867900002207 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 867900002208 amphipathic channel; other site 867900002209 Asn-Pro-Ala signature motifs; other site 867900002210 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 867900002211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 867900002212 putative substrate translocation pore; other site 867900002213 POT family; Region: PTR2; cl17359 867900002214 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 867900002215 homodimer interface [polypeptide binding]; other site 867900002216 catalytic residues [active] 867900002217 NAD binding site [chemical binding]; other site 867900002218 substrate binding pocket [chemical binding]; other site 867900002219 flexible flap; other site 867900002220 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 867900002221 SurA N-terminal domain; Region: SurA_N_3; cl07813 867900002222 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 867900002223 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 867900002224 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 867900002225 Domain of unknown function DUF21; Region: DUF21; pfam01595 867900002226 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 867900002227 Transporter associated domain; Region: CorC_HlyC; smart01091 867900002228 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 867900002229 pantothenate kinase; Reviewed; Region: PRK13320 867900002230 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 867900002231 GIY-YIG motif/motif A; other site 867900002232 putative active site [active] 867900002233 putative metal binding site [ion binding]; other site 867900002234 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 867900002235 GIY-YIG motif/motif A; other site 867900002236 active site 867900002237 catalytic site [active] 867900002238 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 867900002239 active site residue [active] 867900002240 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 867900002241 purine nucleoside phosphorylase; Provisional; Region: PRK08202 867900002242 Protein of unknown function, DUF547; Region: DUF547; pfam04784 867900002243 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 867900002244 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 867900002245 Probable Catalytic site; other site 867900002246 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 867900002247 active site 867900002248 metal binding site [ion binding]; metal-binding site 867900002249 Surface antigen; Region: Bac_surface_Ag; pfam01103 867900002250 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 867900002251 Protein of unknown function, DUF547; Region: DUF547; pfam04784 867900002252 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 867900002253 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 867900002254 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 867900002255 4Fe-4S binding domain; Region: Fer4_5; pfam12801 867900002256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 867900002257 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 867900002258 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 867900002259 Ligand binding site; other site 867900002260 Putative Catalytic site; other site 867900002261 DXD motif; other site 867900002262 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 867900002263 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 867900002264 DXD motif; other site 867900002265 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 867900002266 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 867900002267 Coenzyme A binding pocket [chemical binding]; other site 867900002268 argininosuccinate synthase; Provisional; Region: PRK13820 867900002269 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 867900002270 Ligand Binding Site [chemical binding]; other site 867900002271 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 867900002272 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 867900002273 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 867900002274 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 867900002275 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 867900002276 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 867900002277 inhibitor-cofactor binding pocket; inhibition site 867900002278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 867900002279 catalytic residue [active] 867900002280 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 867900002281 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 867900002282 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 867900002283 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 867900002284 nucleotide binding site [chemical binding]; other site 867900002285 N-acetyl-L-glutamate binding site [chemical binding]; other site 867900002286 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 867900002287 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651 867900002288 metal binding site [ion binding]; metal-binding site 867900002289 dimer interface [polypeptide binding]; other site 867900002290 Lyase; Region: Lyase_1; pfam00206 867900002291 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 867900002292 active sites [active] 867900002293 tetramer interface [polypeptide binding]; other site 867900002294 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 867900002295 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 867900002296 RNA binding surface [nucleotide binding]; other site 867900002297 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 867900002298 active site 867900002299 PQQ-like domain; Region: PQQ_2; pfam13360 867900002300 Predicted amidohydrolase [General function prediction only]; Region: COG0388 867900002301 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 867900002302 putative active site [active] 867900002303 catalytic triad [active] 867900002304 putative dimer interface [polypeptide binding]; other site 867900002305 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 867900002306 UbiA prenyltransferase family; Region: UbiA; pfam01040 867900002307 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 867900002308 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 867900002309 diphosphomevalonate decarboxylase; Region: PLN02407 867900002310 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 867900002311 flavoprotein, HI0933 family; Region: TIGR00275 867900002312 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 867900002313 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 867900002314 active site 867900002315 catalytic site [active] 867900002316 Transcriptional regulators [Transcription]; Region: PurR; COG1609 867900002317 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 867900002318 DNA binding site [nucleotide binding] 867900002319 domain linker motif; other site 867900002320 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 867900002321 dimerization interface [polypeptide binding]; other site 867900002322 ligand binding site [chemical binding]; other site 867900002323 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900002324 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900002325 binding surface 867900002326 TPR motif; other site 867900002327 TPR repeat; Region: TPR_11; pfam13414 867900002328 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900002329 TPR motif; other site 867900002330 binding surface 867900002331 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 867900002332 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 867900002333 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 867900002334 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 867900002335 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 867900002336 Penicillinase repressor; Region: Pencillinase_R; pfam03965 867900002337 Protein of unknown function (DUF456); Region: DUF456; pfam04306 867900002338 M28 Zn-Peptidases; Region: M28_like_1; cd05640 867900002339 Peptidase family M28; Region: Peptidase_M28; pfam04389 867900002340 metal binding site [ion binding]; metal-binding site 867900002341 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 867900002342 putative FMN binding site [chemical binding]; other site 867900002343 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 867900002344 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 867900002345 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 867900002346 dimerization interface [polypeptide binding]; other site 867900002347 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 867900002348 active sites [active] 867900002349 tetramer interface [polypeptide binding]; other site 867900002350 imidazolonepropionase; Validated; Region: PRK09356 867900002351 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 867900002352 active site 867900002353 urocanate hydratase; Provisional; Region: PRK05414 867900002354 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 867900002355 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 867900002356 catalytic residues [active] 867900002357 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 867900002358 Zn binding site [ion binding]; other site 867900002359 Protein of unknown function DUF58; Region: DUF58; pfam01882 867900002360 von Willebrand factor type A domain; Region: VWA_2; pfam13519 867900002361 Protein of unknown function (DUF808); Region: DUF808; cl01002 867900002362 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 867900002363 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 867900002364 non-specific DNA binding site [nucleotide binding]; other site 867900002365 salt bridge; other site 867900002366 sequence-specific DNA binding site [nucleotide binding]; other site 867900002367 Cupin domain; Region: Cupin_2; pfam07883 867900002368 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 867900002369 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 867900002370 Walker A/P-loop; other site 867900002371 ATP binding site [chemical binding]; other site 867900002372 Q-loop/lid; other site 867900002373 ABC transporter signature motif; other site 867900002374 Walker B; other site 867900002375 D-loop; other site 867900002376 H-loop/switch region; other site 867900002377 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 867900002378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 867900002379 dimer interface [polypeptide binding]; other site 867900002380 conserved gate region; other site 867900002381 putative PBP binding loops; other site 867900002382 ABC-ATPase subunit interface; other site 867900002383 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 867900002384 substrate binding pocket [chemical binding]; other site 867900002385 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 867900002386 membrane-bound complex binding site; other site 867900002387 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 867900002388 putative active site [active] 867900002389 putative metal binding site [ion binding]; other site 867900002390 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 867900002391 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 867900002392 active site 867900002393 Phosphotransferase enzyme family; Region: APH; pfam01636 867900002394 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 867900002395 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 867900002396 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 867900002397 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 867900002398 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 867900002399 trimer interface [polypeptide binding]; other site 867900002400 active site 867900002401 UDP-GlcNAc binding site [chemical binding]; other site 867900002402 lipid binding site [chemical binding]; lipid-binding site 867900002403 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 867900002404 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 867900002405 EamA-like transporter family; Region: EamA; pfam00892 867900002406 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 867900002407 PIF1-like helicase; Region: PIF1; pfam05970 867900002408 Walker A motif; other site 867900002409 ATP binding site [chemical binding]; other site 867900002410 Walker B motif; other site 867900002411 Repair protein; Region: Repair_PSII; pfam04536 867900002412 Penicillin amidase; Region: Penicil_amidase; pfam01804 867900002413 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 867900002414 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 867900002415 active site 867900002416 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 867900002417 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 867900002418 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 867900002419 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 867900002420 Walker A/P-loop; other site 867900002421 ATP binding site [chemical binding]; other site 867900002422 Q-loop/lid; other site 867900002423 ABC transporter signature motif; other site 867900002424 Walker B; other site 867900002425 D-loop; other site 867900002426 H-loop/switch region; other site 867900002427 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 867900002428 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 867900002429 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 867900002430 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 867900002431 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 867900002432 NifU-like domain; Region: NifU; pfam01106 867900002433 Domain of unknown function DUF59; Region: DUF59; cl00941 867900002434 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 867900002435 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 867900002436 Walker A motif; other site 867900002437 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 867900002438 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 867900002439 DNA binding site [nucleotide binding] 867900002440 active site 867900002441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 867900002442 S-adenosylmethionine binding site [chemical binding]; other site 867900002443 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 867900002444 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 867900002445 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 867900002446 dimer interface [polypeptide binding]; other site 867900002447 phosphorylation site [posttranslational modification] 867900002448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900002449 ATP binding site [chemical binding]; other site 867900002450 Mg2+ binding site [ion binding]; other site 867900002451 G-X-G motif; other site 867900002452 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 867900002453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900002454 active site 867900002455 phosphorylation site [posttranslational modification] 867900002456 intermolecular recognition site; other site 867900002457 dimerization interface [polypeptide binding]; other site 867900002458 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 867900002459 DNA binding site [nucleotide binding] 867900002460 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 867900002461 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 867900002462 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900002463 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 867900002464 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 867900002465 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 867900002466 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 867900002467 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 867900002468 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900002469 Uncharacterized conserved protein [Function unknown]; Region: COG3379 867900002470 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 867900002471 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 867900002472 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 867900002473 ligand binding site [chemical binding]; other site 867900002474 flexible hinge region; other site 867900002475 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 867900002476 Gram-negative bacterial tonB protein; Region: TonB; cl10048 867900002477 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 867900002478 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 867900002479 RNA binding site [nucleotide binding]; other site 867900002480 active site 867900002481 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 867900002482 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 867900002483 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 867900002484 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 867900002485 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 867900002486 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 867900002487 active site 867900002488 HIGH motif; other site 867900002489 nucleotide binding site [chemical binding]; other site 867900002490 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 867900002491 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 867900002492 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 867900002493 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 867900002494 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 867900002495 active site 867900002496 KMSKS motif; other site 867900002497 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 867900002498 tRNA binding surface [nucleotide binding]; other site 867900002499 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 867900002500 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 867900002501 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 867900002502 hexamer interface [polypeptide binding]; other site 867900002503 ligand binding site [chemical binding]; other site 867900002504 putative active site [active] 867900002505 NAD(P) binding site [chemical binding]; other site 867900002506 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 867900002507 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 867900002508 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 867900002509 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 867900002510 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 867900002511 putative DNA binding site [nucleotide binding]; other site 867900002512 putative Zn2+ binding site [ion binding]; other site 867900002513 AsnC family; Region: AsnC_trans_reg; pfam01037 867900002514 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 867900002515 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 867900002516 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 867900002517 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 867900002518 active site 867900002519 substrate-binding site [chemical binding]; other site 867900002520 metal-binding site [ion binding] 867900002521 ATP binding site [chemical binding]; other site 867900002522 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 867900002523 Helix-turn-helix domain; Region: HTH_18; pfam12833 867900002524 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 867900002525 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 867900002526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 867900002527 putative substrate translocation pore; other site 867900002528 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 867900002529 putative catalytic residues [active] 867900002530 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 867900002531 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 867900002532 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 867900002533 Coenzyme A binding pocket [chemical binding]; other site 867900002534 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 867900002535 putative DNA binding helix; other site 867900002536 metal binding site 2 [ion binding]; metal-binding site 867900002537 metal binding site 1 [ion binding]; metal-binding site 867900002538 dimer interface [polypeptide binding]; other site 867900002539 structural Zn2+ binding site [ion binding]; other site 867900002540 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 867900002541 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 867900002542 ATP-grasp domain; Region: ATP-grasp_4; cl17255 867900002543 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 867900002544 CAAX protease self-immunity; Region: Abi; pfam02517 867900002545 DNA topoisomerase III; Provisional; Region: PRK07726 867900002546 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 867900002547 active site 867900002548 putative interdomain interaction site [polypeptide binding]; other site 867900002549 putative metal-binding site [ion binding]; other site 867900002550 putative nucleotide binding site [chemical binding]; other site 867900002551 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 867900002552 domain I; other site 867900002553 DNA binding groove [nucleotide binding] 867900002554 phosphate binding site [ion binding]; other site 867900002555 domain II; other site 867900002556 domain III; other site 867900002557 nucleotide binding site [chemical binding]; other site 867900002558 catalytic site [active] 867900002559 domain IV; other site 867900002560 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 867900002561 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 867900002562 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 867900002563 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 867900002564 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 867900002565 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 867900002566 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 867900002567 extended (e) SDRs; Region: SDR_e; cd08946 867900002568 NAD(P) binding site [chemical binding]; other site 867900002569 active site 867900002570 substrate binding site [chemical binding]; other site 867900002571 RDD family; Region: RDD; pfam06271 867900002572 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 867900002573 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 867900002574 putative active site [active] 867900002575 putative metal binding site [ion binding]; other site 867900002576 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 867900002577 Right handed beta helix region; Region: Beta_helix; pfam13229 867900002578 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 867900002579 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 867900002580 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 867900002581 Coenzyme A binding pocket [chemical binding]; other site 867900002582 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 867900002583 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 867900002584 potential catalytic triad [active] 867900002585 conserved cys residue [active] 867900002586 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 867900002587 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 867900002588 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 867900002589 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 867900002590 Predicted membrane protein [Function unknown]; Region: COG4270 867900002591 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 867900002592 Bacterial SH3 domain; Region: SH3_3; cl17532 867900002593 DinB family; Region: DinB; cl17821 867900002594 DinB superfamily; Region: DinB_2; pfam12867 867900002595 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 867900002596 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 867900002597 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 867900002598 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 867900002599 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 867900002600 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 867900002601 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 867900002602 active site 867900002603 Domain of unknown function (DUF4271); Region: DUF4271; pfam14093 867900002604 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 867900002605 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 867900002606 Ligand binding site; other site 867900002607 Putative Catalytic site; other site 867900002608 DXD motif; other site 867900002609 dihydroorotase; Reviewed; Region: PRK09236 867900002610 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 867900002611 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 867900002612 active site 867900002613 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 867900002614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 867900002615 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 867900002616 NAD(P) binding site [chemical binding]; other site 867900002617 active site 867900002618 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 867900002619 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 867900002620 active site 867900002621 HIGH motif; other site 867900002622 dimer interface [polypeptide binding]; other site 867900002623 KMSKS motif; other site 867900002624 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 867900002625 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 867900002626 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 867900002627 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 867900002628 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 867900002629 DNA binding residues [nucleotide binding] 867900002630 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 867900002631 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 867900002632 cofactor binding site; other site 867900002633 DNA binding site [nucleotide binding] 867900002634 substrate interaction site [chemical binding]; other site 867900002635 Eco47II restriction endonuclease; Region: RE_Eco47II; pfam09553 867900002636 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 867900002637 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 867900002638 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 867900002639 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 867900002640 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 867900002641 phosphorylation site [posttranslational modification] 867900002642 dimer interface [polypeptide binding]; other site 867900002643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900002644 ATP binding site [chemical binding]; other site 867900002645 Mg2+ binding site [ion binding]; other site 867900002646 G-X-G motif; other site 867900002647 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 867900002648 nucleotide binding site/active site [active] 867900002649 HIT family signature motif; other site 867900002650 catalytic residue [active] 867900002651 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 867900002652 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 867900002653 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 867900002654 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 867900002655 iron-sulfur cluster [ion binding]; other site 867900002656 [2Fe-2S] cluster binding site [ion binding]; other site 867900002657 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 867900002658 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900002659 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 867900002660 active site 867900002661 metal binding site [ion binding]; metal-binding site 867900002662 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 867900002663 Domain of unknown function (DUF4301); Region: DUF4301; pfam14134 867900002664 AAA domain; Region: AAA_28; pfam13521 867900002665 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 867900002666 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 867900002667 Domain of unknown function DUF77; Region: DUF77; cl00307 867900002668 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 867900002669 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 867900002670 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 867900002671 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 867900002672 homotetramer interface [polypeptide binding]; other site 867900002673 ligand binding site [chemical binding]; other site 867900002674 catalytic site [active] 867900002675 NAD binding site [chemical binding]; other site 867900002676 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 867900002677 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 867900002678 NAD(P) binding site [chemical binding]; other site 867900002679 active site 867900002680 Phytase; Region: Phytase; cl17685 867900002681 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 867900002682 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 867900002683 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900002684 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900002685 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900002686 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900002687 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900002688 binding surface 867900002689 TPR motif; other site 867900002690 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900002691 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900002692 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900002693 binding surface 867900002694 TPR motif; other site 867900002695 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900002696 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 867900002697 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 867900002698 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 867900002699 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 867900002700 Uncharacterized conserved protein [Function unknown]; Region: COG3743 867900002701 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 867900002702 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 867900002703 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 867900002704 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 867900002705 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 867900002706 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 867900002707 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 867900002708 metal-binding site [ion binding] 867900002709 gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512 867900002710 gliding motility-associated protein GldE; Region: GldE; TIGR03520 867900002711 Domain of unknown function DUF21; Region: DUF21; pfam01595 867900002712 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 867900002713 Transporter associated domain; Region: CorC_HlyC; smart01091 867900002714 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 867900002715 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 867900002716 dimer interface [polypeptide binding]; other site 867900002717 ssDNA binding site [nucleotide binding]; other site 867900002718 tetramer (dimer of dimers) interface [polypeptide binding]; other site 867900002719 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 867900002720 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 867900002721 minor groove reading motif; other site 867900002722 helix-hairpin-helix signature motif; other site 867900002723 substrate binding pocket [chemical binding]; other site 867900002724 active site 867900002725 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 867900002726 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 867900002727 DNA binding and oxoG recognition site [nucleotide binding] 867900002728 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 867900002729 IHF - DNA interface [nucleotide binding]; other site 867900002730 IHF dimer interface [polypeptide binding]; other site 867900002731 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 867900002732 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 867900002733 homodimer interface [polypeptide binding]; other site 867900002734 oligonucleotide binding site [chemical binding]; other site 867900002735 RecX family; Region: RecX; pfam02631 867900002736 Cupin-like domain; Region: Cupin_8; pfam13621 867900002737 biotin synthase; Region: bioB; TIGR00433 867900002738 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 867900002739 FeS/SAM binding site; other site 867900002740 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 867900002741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 867900002742 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 867900002743 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 867900002744 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 867900002745 active site 867900002746 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 867900002747 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 867900002748 inhibitor-cofactor binding pocket; inhibition site 867900002749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 867900002750 catalytic residue [active] 867900002751 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 867900002752 AAA domain; Region: AAA_26; pfam13500 867900002753 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 867900002754 Uncharacterized conserved protein (DUF2367); Region: DUF2367; pfam10164 867900002755 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 867900002756 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 867900002757 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 867900002758 catalytic residue [active] 867900002759 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 867900002760 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 867900002761 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 867900002762 active site 867900002763 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 867900002764 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 867900002765 active site 867900002766 DNA binding site [nucleotide binding] 867900002767 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 867900002768 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 867900002769 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 867900002770 Catalytic site [active] 867900002771 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 867900002772 gamma subunit interface [polypeptide binding]; other site 867900002773 LBP interface [polypeptide binding]; other site 867900002774 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 867900002775 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 867900002776 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 867900002777 alpha subunit interaction interface [polypeptide binding]; other site 867900002778 Walker A motif; other site 867900002779 ATP binding site [chemical binding]; other site 867900002780 Walker B motif; other site 867900002781 inhibitor binding site; inhibition site 867900002782 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 867900002783 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 867900002784 catalytic triad [active] 867900002785 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900002786 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 867900002787 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 867900002788 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900002789 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900002790 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 867900002791 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 867900002792 glutaminase active site [active] 867900002793 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 867900002794 dimer interface [polypeptide binding]; other site 867900002795 active site 867900002796 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 867900002797 dimer interface [polypeptide binding]; other site 867900002798 active site 867900002799 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 867900002800 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 867900002801 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 867900002802 pantoate--beta-alanine ligase; Region: panC; TIGR00018 867900002803 Pantoate-beta-alanine ligase; Region: PanC; cd00560 867900002804 active site 867900002805 ATP-binding site [chemical binding]; other site 867900002806 pantoate-binding site; other site 867900002807 HXXH motif; other site 867900002808 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 867900002809 tetramerization interface [polypeptide binding]; other site 867900002810 active site 867900002811 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 867900002812 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 867900002813 Putative esterase; Region: Esterase; pfam00756 867900002814 DNA repair protein RadA; Provisional; Region: PRK11823 867900002815 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 867900002816 Walker A motif/ATP binding site; other site 867900002817 ATP binding site [chemical binding]; other site 867900002818 Walker B motif; other site 867900002819 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 867900002820 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 867900002821 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 867900002822 active site 867900002823 catalytic tetrad [active] 867900002824 Cytochrome c; Region: Cytochrom_C; pfam00034 867900002825 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 867900002826 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 867900002827 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 867900002828 FMN binding site [chemical binding]; other site 867900002829 substrate binding site [chemical binding]; other site 867900002830 putative catalytic residue [active] 867900002831 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 867900002832 active site 867900002833 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 867900002834 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 867900002835 ArsC family; Region: ArsC; pfam03960 867900002836 catalytic residue [active] 867900002837 DinB superfamily; Region: DinB_2; pfam12867 867900002838 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 867900002839 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 867900002840 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 867900002841 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 867900002842 homodimer interface [polypeptide binding]; other site 867900002843 substrate-cofactor binding pocket; other site 867900002844 pyridoxal 5'-phosphate binding site [chemical binding]; other site 867900002845 catalytic residue [active] 867900002846 glutamate dehydrogenase; Provisional; Region: PRK09414 867900002847 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 867900002848 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 867900002849 NAD(P) binding site [chemical binding]; other site 867900002850 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 867900002851 Recombination protein O N terminal; Region: RecO_N; pfam11967 867900002852 Recombination protein O C terminal; Region: RecO_C; pfam02565 867900002853 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900002854 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 867900002855 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 867900002856 N-terminal plug; other site 867900002857 ligand-binding site [chemical binding]; other site 867900002858 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 867900002859 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 867900002860 HIGH motif; other site 867900002861 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 867900002862 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 867900002863 active site 867900002864 KMSKS motif; other site 867900002865 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 867900002866 tRNA binding surface [nucleotide binding]; other site 867900002867 anticodon binding site; other site 867900002868 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 867900002869 lipoprotein signal peptidase; Provisional; Region: PRK14788 867900002870 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 867900002871 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 867900002872 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 867900002873 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 867900002874 GIY-YIG motif/motif A; other site 867900002875 active site 867900002876 catalytic site [active] 867900002877 putative DNA binding site [nucleotide binding]; other site 867900002878 metal binding site [ion binding]; metal-binding site 867900002879 Y-family of DNA polymerases; Region: PolY; cl12025 867900002880 DNA binding site [nucleotide binding] 867900002881 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 867900002882 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 867900002883 DNA binding site [nucleotide binding] 867900002884 hypothetical protein; Provisional; Region: PRK10279 867900002885 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 867900002886 nucleophile elbow; other site 867900002887 Surface antigen; Region: Bac_surface_Ag; pfam01103 867900002888 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 867900002889 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 867900002890 dimer interface [polypeptide binding]; other site 867900002891 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 867900002892 active site 867900002893 Fe binding site [ion binding]; other site 867900002894 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 867900002895 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 867900002896 putative peptidase; Provisional; Region: PRK11649 867900002897 Peptidase family M23; Region: Peptidase_M23; pfam01551 867900002898 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 867900002899 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 867900002900 active site 867900002901 dimer interface [polypeptide binding]; other site 867900002902 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 867900002903 dimer interface [polypeptide binding]; other site 867900002904 active site 867900002905 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900002906 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 867900002907 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900002908 Endonuclease I; Region: Endonuclease_1; pfam04231 867900002909 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 867900002910 putative catalytic site [active] 867900002911 putative metal binding site [ion binding]; other site 867900002912 putative phosphate binding site [ion binding]; other site 867900002913 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900002914 Lamin Tail Domain; Region: LTD; pfam00932 867900002915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900002916 Response regulator receiver domain; Region: Response_reg; pfam00072 867900002917 active site 867900002918 phosphorylation site [posttranslational modification] 867900002919 intermolecular recognition site; other site 867900002920 dimerization interface [polypeptide binding]; other site 867900002921 PAS domain S-box; Region: sensory_box; TIGR00229 867900002922 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 867900002923 PAS fold; Region: PAS_3; pfam08447 867900002924 putative active site [active] 867900002925 heme pocket [chemical binding]; other site 867900002926 PAS domain S-box; Region: sensory_box; TIGR00229 867900002927 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 867900002928 putative active site [active] 867900002929 heme pocket [chemical binding]; other site 867900002930 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 867900002931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900002932 ATP binding site [chemical binding]; other site 867900002933 Mg2+ binding site [ion binding]; other site 867900002934 G-X-G motif; other site 867900002935 metal-dependent hydrolase; Provisional; Region: PRK13291 867900002936 DinB superfamily; Region: DinB_2; pfam12867 867900002937 Predicted amidohydrolase [General function prediction only]; Region: COG0388 867900002938 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 867900002939 putative active site [active] 867900002940 catalytic triad [active] 867900002941 dimer interface [polypeptide binding]; other site 867900002942 multimer interface [polypeptide binding]; other site 867900002943 Bacterial Ig-like domain; Region: Big_5; pfam13205 867900002944 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930 867900002945 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 867900002946 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 867900002947 active site 867900002948 glycyl-tRNA synthetase; Provisional; Region: PRK04173 867900002949 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 867900002950 motif 1; other site 867900002951 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 867900002952 active site 867900002953 motif 2; other site 867900002954 motif 3; other site 867900002955 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 867900002956 anticodon binding site; other site 867900002957 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 867900002958 putative active site [active] 867900002959 putative catalytic site [active] 867900002960 putative DNA binding site [nucleotide binding]; other site 867900002961 putative phosphate binding site [ion binding]; other site 867900002962 metal binding site A [ion binding]; metal-binding site 867900002963 putative AP binding site [nucleotide binding]; other site 867900002964 putative metal binding site B [ion binding]; other site 867900002965 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 867900002966 active site 867900002967 catalytic residues [active] 867900002968 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 867900002969 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 867900002970 Sulfate transporter family; Region: Sulfate_transp; pfam00916 867900002971 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 867900002972 malate:quinone oxidoreductase; Validated; Region: PRK05257 867900002973 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 867900002974 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 867900002975 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 867900002976 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 867900002977 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 867900002978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 867900002979 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 867900002980 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 867900002981 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 867900002982 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 867900002983 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 867900002984 Transglycosylase; Region: Transgly; pfam00912 867900002985 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 867900002986 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 867900002987 Colicin V production protein; Region: Colicin_V; pfam02674 867900002988 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 867900002989 MG2 domain; Region: A2M_N; pfam01835 867900002990 Alpha-2-macroglobulin family; Region: A2M; pfam00207 867900002991 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 867900002992 surface patch; other site 867900002993 thioester region; other site 867900002994 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 867900002995 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 867900002996 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 867900002997 aldehyde dehydrogenase family 7 member; Region: PLN02315 867900002998 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 867900002999 tetrameric interface [polypeptide binding]; other site 867900003000 NAD binding site [chemical binding]; other site 867900003001 catalytic residues [active] 867900003002 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 867900003003 ligand binding site [chemical binding]; other site 867900003004 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 867900003005 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 867900003006 ligand binding site [chemical binding]; other site 867900003007 Uncharacterized conserved protein [Function unknown]; Region: COG3743 867900003008 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 867900003009 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 867900003010 homodimer interface [polypeptide binding]; other site 867900003011 putative substrate binding pocket [chemical binding]; other site 867900003012 diiron center [ion binding]; other site 867900003013 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 867900003014 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 867900003015 active site 867900003016 metal binding site [ion binding]; metal-binding site 867900003017 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 867900003018 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 867900003019 Divergent AAA domain; Region: AAA_4; pfam04326 867900003020 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 867900003021 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 867900003022 putative NAD(P) binding site [chemical binding]; other site 867900003023 homotetramer interface [polypeptide binding]; other site 867900003024 homodimer interface [polypeptide binding]; other site 867900003025 active site 867900003026 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 867900003027 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 867900003028 active site 867900003029 catalytic tetrad [active] 867900003030 MoxR-like ATPases [General function prediction only]; Region: COG0714 867900003031 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 867900003032 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 867900003033 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 867900003034 metal ion-dependent adhesion site (MIDAS); other site 867900003035 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 867900003036 metal ion-dependent adhesion site (MIDAS); other site 867900003037 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 867900003038 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 867900003039 metal ion-dependent adhesion site (MIDAS); other site 867900003040 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900003041 TPR repeat; Region: TPR_11; pfam13414 867900003042 TPR motif; other site 867900003043 binding surface 867900003044 Oxygen tolerance; Region: BatD; pfam13584 867900003045 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900003046 binding surface 867900003047 Tetratricopeptide repeat; Region: TPR_16; pfam13432 867900003048 TPR motif; other site 867900003049 Bacterial SH3 domain; Region: SH3_3; pfam08239 867900003050 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 867900003051 active site clefts [active] 867900003052 zinc binding site [ion binding]; other site 867900003053 dimer interface [polypeptide binding]; other site 867900003054 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 867900003055 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 867900003056 Sulfate transporter family; Region: Sulfate_transp; pfam00916 867900003057 Sulfate transporter family; Region: Sulfate_transp; pfam00916 867900003058 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 867900003059 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 867900003060 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 867900003061 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 867900003062 dimer interface [polypeptide binding]; other site 867900003063 motif 1; other site 867900003064 active site 867900003065 motif 2; other site 867900003066 motif 3; other site 867900003067 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 867900003068 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 867900003069 ATP-grasp domain; Region: ATP-grasp_4; cl17255 867900003070 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 867900003071 putative active site [active] 867900003072 putative metal binding residues [ion binding]; other site 867900003073 signature motif; other site 867900003074 putative dimer interface [polypeptide binding]; other site 867900003075 putative phosphate binding site [ion binding]; other site 867900003076 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 867900003077 NADH(P)-binding; Region: NAD_binding_10; pfam13460 867900003078 NAD binding site [chemical binding]; other site 867900003079 active site 867900003080 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 867900003081 active site 867900003082 DNA polymerase IV; Validated; Region: PRK02406 867900003083 DNA binding site [nucleotide binding] 867900003084 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 867900003085 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 867900003086 dimer interface [polypeptide binding]; other site 867900003087 decamer (pentamer of dimers) interface [polypeptide binding]; other site 867900003088 catalytic triad [active] 867900003089 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 867900003090 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 867900003091 dimer interface [polypeptide binding]; other site 867900003092 phosphorylation site [posttranslational modification] 867900003093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900003094 ATP binding site [chemical binding]; other site 867900003095 Mg2+ binding site [ion binding]; other site 867900003096 G-X-G motif; other site 867900003097 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 867900003098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900003099 active site 867900003100 phosphorylation site [posttranslational modification] 867900003101 intermolecular recognition site; other site 867900003102 dimerization interface [polypeptide binding]; other site 867900003103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 867900003104 Walker A motif; other site 867900003105 ATP binding site [chemical binding]; other site 867900003106 Walker B motif; other site 867900003107 arginine finger; other site 867900003108 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 867900003109 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 867900003110 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 867900003111 NAD(P) binding site [chemical binding]; other site 867900003112 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 867900003113 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 867900003114 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 867900003115 Walker A/P-loop; other site 867900003116 ATP binding site [chemical binding]; other site 867900003117 Q-loop/lid; other site 867900003118 ABC transporter signature motif; other site 867900003119 Walker B; other site 867900003120 D-loop; other site 867900003121 H-loop/switch region; other site 867900003122 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 867900003123 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 867900003124 FtsX-like permease family; Region: FtsX; pfam02687 867900003125 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 867900003126 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 867900003127 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 867900003128 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 867900003129 FtsX-like permease family; Region: FtsX; pfam02687 867900003130 FtsX-like permease family; Region: FtsX; pfam02687 867900003131 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 867900003132 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 867900003133 FtsX-like permease family; Region: FtsX; pfam02687 867900003134 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 867900003135 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 867900003136 FtsX-like permease family; Region: FtsX; pfam02687 867900003137 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 867900003138 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 867900003139 FtsX-like permease family; Region: FtsX; pfam02687 867900003140 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 867900003141 FtsX-like permease family; Region: FtsX; pfam02687 867900003142 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 867900003143 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 867900003144 FtsX-like permease family; Region: FtsX; pfam02687 867900003145 FtsX-like permease family; Region: FtsX; pfam02687 867900003146 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 867900003147 FtsX-like permease family; Region: FtsX; pfam02687 867900003148 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 867900003149 FtsX-like permease family; Region: FtsX; pfam02687 867900003150 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 867900003151 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 867900003152 Walker A/P-loop; other site 867900003153 ATP binding site [chemical binding]; other site 867900003154 Q-loop/lid; other site 867900003155 ABC transporter signature motif; other site 867900003156 Walker B; other site 867900003157 D-loop; other site 867900003158 H-loop/switch region; other site 867900003159 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 867900003160 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 867900003161 HlyD family secretion protein; Region: HlyD_3; pfam13437 867900003162 Outer membrane efflux protein; Region: OEP; pfam02321 867900003163 Outer membrane efflux protein; Region: OEP; pfam02321 867900003164 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 867900003165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900003166 active site 867900003167 phosphorylation site [posttranslational modification] 867900003168 intermolecular recognition site; other site 867900003169 dimerization interface [polypeptide binding]; other site 867900003170 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 867900003171 Walker A motif; other site 867900003172 ATP binding site [chemical binding]; other site 867900003173 Walker B motif; other site 867900003174 arginine finger; other site 867900003175 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 867900003176 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 867900003177 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 867900003178 putative active site [active] 867900003179 heme pocket [chemical binding]; other site 867900003180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900003181 ATP binding site [chemical binding]; other site 867900003182 Mg2+ binding site [ion binding]; other site 867900003183 G-X-G motif; other site 867900003184 hypothetical protein; Provisional; Region: PRK09256 867900003185 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 867900003186 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 867900003187 Walker A/P-loop; other site 867900003188 ATP binding site [chemical binding]; other site 867900003189 Q-loop/lid; other site 867900003190 ABC transporter signature motif; other site 867900003191 Walker B; other site 867900003192 D-loop; other site 867900003193 H-loop/switch region; other site 867900003194 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 867900003195 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 867900003196 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 867900003197 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 867900003198 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 867900003199 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 867900003200 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 867900003201 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 867900003202 alanine racemase; Reviewed; Region: alr; PRK00053 867900003203 active site 867900003204 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 867900003205 dimer interface [polypeptide binding]; other site 867900003206 substrate binding site [chemical binding]; other site 867900003207 catalytic residues [active] 867900003208 thymidine kinase; Provisional; Region: PRK04296 867900003209 DoxX-like family; Region: DoxX_2; pfam13564 867900003210 Predicted methyltransferases [General function prediction only]; Region: COG0313 867900003211 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 867900003212 putative SAM binding site [chemical binding]; other site 867900003213 putative homodimer interface [polypeptide binding]; other site 867900003214 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 867900003215 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 867900003216 M28 Zn-Peptidases; Region: M28_like_7; cd05643 867900003217 Peptidase family M28; Region: Peptidase_M28; pfam04389 867900003218 putative metal binding site [ion binding]; other site 867900003219 HopJ type III effector protein; Region: HopJ; pfam08888 867900003220 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 867900003221 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 867900003222 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 867900003223 four helix bundle protein; Region: TIGR02436 867900003224 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 867900003225 DHH family; Region: DHH; pfam01368 867900003226 DHHA1 domain; Region: DHHA1; pfam02272 867900003227 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 867900003228 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 867900003229 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 867900003230 N-terminal plug; other site 867900003231 ligand-binding site [chemical binding]; other site 867900003232 FMN-binding domain; Region: FMN_bind; pfam04205 867900003233 enterobactin exporter EntS; Provisional; Region: PRK10489 867900003234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 867900003235 putative substrate translocation pore; other site 867900003236 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 867900003237 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 867900003238 ligand binding site [chemical binding]; other site 867900003239 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 867900003240 putative active site [active] 867900003241 putative metal binding site [ion binding]; other site 867900003242 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 867900003243 active site 867900003244 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 867900003245 active site clefts [active] 867900003246 zinc binding site [ion binding]; other site 867900003247 dimer interface [polypeptide binding]; other site 867900003248 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 867900003249 Ligand Binding Site [chemical binding]; other site 867900003250 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 867900003251 Sulfate transporter family; Region: Sulfate_transp; pfam00916 867900003252 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 867900003253 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 867900003254 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 867900003255 substrate binding site [chemical binding]; other site 867900003256 oxyanion hole (OAH) forming residues; other site 867900003257 trimer interface [polypeptide binding]; other site 867900003258 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 867900003259 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 867900003260 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 867900003261 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 867900003262 Coenzyme A binding pocket [chemical binding]; other site 867900003263 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 867900003264 Ligand Binding Site [chemical binding]; other site 867900003265 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 867900003266 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 867900003267 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 867900003268 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 867900003269 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 867900003270 starch binding outer membrane protein SusD; Region: SusD; cd08977 867900003271 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 867900003272 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900003273 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900003274 FecR protein; Region: FecR; pfam04773 867900003275 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 867900003276 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 867900003277 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 867900003278 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 867900003279 DNA binding residues [nucleotide binding] 867900003280 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 867900003281 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 867900003282 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 867900003283 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 867900003284 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900003285 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 867900003286 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 867900003287 starch binding outer membrane protein SusD; Region: SusD; cl17845 867900003288 SusD family; Region: SusD; pfam07980 867900003289 Domain of unknown function (DUF377); Region: DUF377; pfam04041 867900003290 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 867900003291 active site 867900003292 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 867900003293 Na binding site [ion binding]; other site 867900003294 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 867900003295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900003296 active site 867900003297 phosphorylation site [posttranslational modification] 867900003298 intermolecular recognition site; other site 867900003299 dimerization interface [polypeptide binding]; other site 867900003300 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 867900003301 Ligand binding site; other site 867900003302 Ligand binding site; other site 867900003303 Ligand binding site; other site 867900003304 Putative Catalytic site; other site 867900003305 DXD motif; other site 867900003306 Predicted integral membrane protein [Function unknown]; Region: COG5617 867900003307 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 867900003308 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 867900003309 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 867900003310 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 867900003311 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 867900003312 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 867900003313 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 867900003314 TPR repeat; Region: TPR_11; pfam13414 867900003315 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900003316 binding surface 867900003317 TPR motif; other site 867900003318 Tetratricopeptide repeat; Region: TPR_16; pfam13432 867900003319 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 867900003320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900003321 active site 867900003322 phosphorylation site [posttranslational modification] 867900003323 intermolecular recognition site; other site 867900003324 dimerization interface [polypeptide binding]; other site 867900003325 LytTr DNA-binding domain; Region: LytTR; smart00850 867900003326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900003327 ATP binding site [chemical binding]; other site 867900003328 Mg2+ binding site [ion binding]; other site 867900003329 G-X-G motif; other site 867900003330 Uncharacterized conserved protein [Function unknown]; Region: COG3287 867900003331 FIST N domain; Region: FIST; pfam08495 867900003332 FIST C domain; Region: FIST_C; pfam10442 867900003333 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 867900003334 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 867900003335 putative active site [active] 867900003336 heme pocket [chemical binding]; other site 867900003337 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 867900003338 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 867900003339 putative active site [active] 867900003340 heme pocket [chemical binding]; other site 867900003341 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 867900003342 putative active site [active] 867900003343 heme pocket [chemical binding]; other site 867900003344 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 867900003345 dimer interface [polypeptide binding]; other site 867900003346 phosphorylation site [posttranslational modification] 867900003347 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900003348 ATP binding site [chemical binding]; other site 867900003349 Mg2+ binding site [ion binding]; other site 867900003350 G-X-G motif; other site 867900003351 Heme NO binding; Region: HNOB; pfam07700 867900003352 Response regulator receiver domain; Region: Response_reg; pfam00072 867900003353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900003354 active site 867900003355 phosphorylation site [posttranslational modification] 867900003356 intermolecular recognition site; other site 867900003357 dimerization interface [polypeptide binding]; other site 867900003358 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 867900003359 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 867900003360 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 867900003361 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 867900003362 ligand binding site [chemical binding]; other site 867900003363 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 867900003364 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 867900003365 substrate-cofactor binding pocket; other site 867900003366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 867900003367 catalytic residue [active] 867900003368 Part of AAA domain; Region: AAA_19; pfam13245 867900003369 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 867900003370 Family description; Region: UvrD_C_2; pfam13538 867900003371 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 867900003372 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 867900003373 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 867900003374 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 867900003375 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 867900003376 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 867900003377 active site 867900003378 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 867900003379 active site 867900003380 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 867900003381 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 867900003382 substrate binding site [chemical binding]; other site 867900003383 ATP binding site [chemical binding]; other site 867900003384 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 867900003385 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 867900003386 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 867900003387 active site 867900003388 RNA/DNA hybrid binding site [nucleotide binding]; other site 867900003389 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 867900003390 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 867900003391 active site 867900003392 substrate binding site [chemical binding]; other site 867900003393 cosubstrate binding site; other site 867900003394 catalytic site [active] 867900003395 acyl carrier protein; Provisional; Region: acpP; PRK00982 867900003396 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 867900003397 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 867900003398 dimer interface [polypeptide binding]; other site 867900003399 active site 867900003400 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 867900003401 dimerization interface [polypeptide binding]; other site 867900003402 active site 867900003403 metal binding site [ion binding]; metal-binding site 867900003404 Double-stranded RNA binding motif; Region: dsrm; pfam00035 867900003405 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 867900003406 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 867900003407 domain interfaces; other site 867900003408 active site 867900003409 Helix-turn-helix domain; Region: HTH_18; pfam12833 867900003410 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 867900003411 Uncharacterized conserved protein [Function unknown]; Region: COG2128 867900003412 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 867900003413 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 867900003414 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 867900003415 hydroxyglutarate oxidase; Provisional; Region: PRK11728 867900003416 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 867900003417 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 867900003418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 867900003419 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 867900003420 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 867900003421 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 867900003422 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 867900003423 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 867900003424 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 867900003425 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 867900003426 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 867900003427 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 867900003428 carboxyltransferase (CT) interaction site; other site 867900003429 biotinylation site [posttranslational modification]; other site 867900003430 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 867900003431 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 867900003432 dimer interface [polypeptide binding]; other site 867900003433 active site 867900003434 CoA binding pocket [chemical binding]; other site 867900003435 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 867900003436 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 867900003437 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 867900003438 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 867900003439 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 867900003440 Lumazine binding domain; Region: Lum_binding; pfam00677 867900003441 Lumazine binding domain; Region: Lum_binding; pfam00677 867900003442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 867900003443 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 867900003444 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 867900003445 Na binding site [ion binding]; other site 867900003446 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 867900003447 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 867900003448 DNA binding residues [nucleotide binding] 867900003449 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 867900003450 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900003451 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 867900003452 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 867900003453 starch binding outer membrane protein SusD; Region: SusD; cl17845 867900003454 SusD family; Region: SusD; pfam07980 867900003455 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 867900003456 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 867900003457 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 867900003458 Putative glucoamylase; Region: Glycoamylase; pfam10091 867900003459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 867900003460 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 867900003461 Putative glucoamylase; Region: Glycoamylase; pfam10091 867900003462 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 867900003463 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 867900003464 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 867900003465 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 867900003466 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 867900003467 substrate binding pocket [chemical binding]; other site 867900003468 Sulfatase; Region: Sulfatase; cl17466 867900003469 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 867900003470 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 867900003471 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 867900003472 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 867900003473 putative active site [active] 867900003474 putative metal binding site [ion binding]; other site 867900003475 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 867900003476 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 867900003477 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 867900003478 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 867900003479 Predicted transcriptional regulator [Transcription]; Region: COG2378 867900003480 WYL domain; Region: WYL; pfam13280 867900003481 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 867900003482 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 867900003483 dimer interface [polypeptide binding]; other site 867900003484 substrate binding site [chemical binding]; other site 867900003485 metal binding site [ion binding]; metal-binding site 867900003486 Ribosome-binding factor A; Region: RBFA; pfam02033 867900003487 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 867900003488 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 867900003489 FtsX-like permease family; Region: FtsX; pfam02687 867900003490 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 867900003491 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 867900003492 FMN binding site [chemical binding]; other site 867900003493 active site 867900003494 catalytic residues [active] 867900003495 substrate binding site [chemical binding]; other site 867900003496 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 867900003497 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 867900003498 ligand binding site [chemical binding]; other site 867900003499 GTP-binding protein LepA; Provisional; Region: PRK05433 867900003500 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 867900003501 G1 box; other site 867900003502 putative GEF interaction site [polypeptide binding]; other site 867900003503 GTP/Mg2+ binding site [chemical binding]; other site 867900003504 Switch I region; other site 867900003505 G2 box; other site 867900003506 G3 box; other site 867900003507 Switch II region; other site 867900003508 G4 box; other site 867900003509 G5 box; other site 867900003510 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 867900003511 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 867900003512 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 867900003513 Histidine kinase; Region: His_kinase; pfam06580 867900003514 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 867900003515 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900003516 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 867900003517 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 867900003518 TrkA-N domain; Region: TrkA_N; pfam02254 867900003519 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 867900003520 Ligand Binding Site [chemical binding]; other site 867900003521 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 867900003522 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 867900003523 Sulfate transporter family; Region: Sulfate_transp; pfam00916 867900003524 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 867900003525 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 867900003526 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 867900003527 Peptidase S8 family domain in Subtilisin_Novo-like proteins; Region: Peptidases_S8_Subtilisin_Novo-like; cd07483 867900003528 active site 867900003529 catalytic triad [active] 867900003530 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 867900003531 Zn binding site [ion binding]; other site 867900003532 ribonuclease P; Reviewed; Region: rnpA; PRK01903 867900003533 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 867900003534 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 867900003535 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 867900003536 protein binding site [polypeptide binding]; other site 867900003537 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 867900003538 Catalytic dyad [active] 867900003539 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 867900003540 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 867900003541 NlpC/P60 family; Region: NLPC_P60; pfam00877 867900003542 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 867900003543 Coenzyme A binding pocket [chemical binding]; other site 867900003544 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 867900003545 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 867900003546 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 867900003547 Clp amino terminal domain; Region: Clp_N; pfam02861 867900003548 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 867900003549 active site 867900003550 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 867900003551 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 867900003552 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 867900003553 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 867900003554 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 867900003555 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 867900003556 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 867900003557 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 867900003558 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 867900003559 active site 867900003560 HIGH motif; other site 867900003561 nucleotide binding site [chemical binding]; other site 867900003562 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 867900003563 active site 867900003564 KMSKS motif; other site 867900003565 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 867900003566 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 867900003567 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 867900003568 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 867900003569 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 867900003570 active site 867900003571 HIGH motif; other site 867900003572 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 867900003573 active site 867900003574 KMSKS motif; other site 867900003575 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 867900003576 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 867900003577 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 867900003578 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 867900003579 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 867900003580 Methyltransferase domain; Region: Methyltransf_23; pfam13489 867900003581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 867900003582 S-adenosylmethionine binding site [chemical binding]; other site 867900003583 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 867900003584 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 867900003585 dimer interface [polypeptide binding]; other site 867900003586 phosphorylation site [posttranslational modification] 867900003587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900003588 ATP binding site [chemical binding]; other site 867900003589 Mg2+ binding site [ion binding]; other site 867900003590 G-X-G motif; other site 867900003591 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 867900003592 dimer interface [polypeptide binding]; other site 867900003593 phosphorylation site [posttranslational modification] 867900003594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900003595 ATP binding site [chemical binding]; other site 867900003596 Mg2+ binding site [ion binding]; other site 867900003597 G-X-G motif; other site 867900003598 YCII-related domain; Region: YCII; cl00999 867900003599 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 867900003600 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 867900003601 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 867900003602 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 867900003603 active site 867900003604 substrate binding site [chemical binding]; other site 867900003605 ATP binding site [chemical binding]; other site 867900003606 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 867900003607 DNA polymerase III subunit delta'; Validated; Region: PRK08485 867900003608 Phosphoglycerate kinase; Region: PGK; pfam00162 867900003609 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 867900003610 substrate binding site [chemical binding]; other site 867900003611 hinge regions; other site 867900003612 ADP binding site [chemical binding]; other site 867900003613 catalytic site [active] 867900003614 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 867900003615 N-acetyl-D-glucosamine binding site [chemical binding]; other site 867900003616 catalytic residue [active] 867900003617 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 867900003618 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 867900003619 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 867900003620 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 867900003621 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 867900003622 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 867900003623 ligand binding site [chemical binding]; other site 867900003624 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 867900003625 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 867900003626 Peptidase family M23; Region: Peptidase_M23; pfam01551 867900003627 GH3 auxin-responsive promoter; Region: GH3; pfam03321 867900003628 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 867900003629 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 867900003630 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 867900003631 NAD binding site [chemical binding]; other site 867900003632 substrate binding site [chemical binding]; other site 867900003633 homodimer interface [polypeptide binding]; other site 867900003634 active site 867900003635 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 867900003636 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 867900003637 substrate binding site; other site 867900003638 tetramer interface; other site 867900003639 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 867900003640 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 867900003641 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 867900003642 NADP binding site [chemical binding]; other site 867900003643 active site 867900003644 putative substrate binding site [chemical binding]; other site 867900003645 probable UDP-glucose 6-dehydrogenase; Region: PLN02353 867900003646 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 867900003647 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 867900003648 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 867900003649 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 867900003650 active site 867900003651 homodimer interface [polypeptide binding]; other site 867900003652 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 867900003653 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 867900003654 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 867900003655 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 867900003656 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 867900003657 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 867900003658 O-Antigen ligase; Region: Wzy_C; pfam04932 867900003659 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 867900003660 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 867900003661 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 867900003662 NAD binding site [chemical binding]; other site 867900003663 putative substrate binding site 2 [chemical binding]; other site 867900003664 putative substrate binding site 1 [chemical binding]; other site 867900003665 active site 867900003666 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 867900003667 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 867900003668 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 867900003669 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 867900003670 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 867900003671 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 867900003672 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 867900003673 putative active site [active] 867900003674 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 867900003675 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 867900003676 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; pfam09837 867900003677 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 867900003678 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900003679 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 867900003680 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900003681 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 867900003682 starch binding outer membrane protein SusD; Region: SusD; cl17845 867900003683 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 867900003684 active site 867900003685 Predicted kinase [General function prediction only]; Region: COG4857; cl17281 867900003686 Phosphotransferase enzyme family; Region: APH; pfam01636 867900003687 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 867900003688 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 867900003689 active site 867900003690 nucleophile elbow; other site 867900003691 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 867900003692 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 867900003693 FAD binding pocket [chemical binding]; other site 867900003694 FAD binding motif [chemical binding]; other site 867900003695 phosphate binding motif [ion binding]; other site 867900003696 beta-alpha-beta structure motif; other site 867900003697 NAD(p) ribose binding residues [chemical binding]; other site 867900003698 NAD binding pocket [chemical binding]; other site 867900003699 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 867900003700 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 867900003701 catalytic loop [active] 867900003702 iron binding site [ion binding]; other site 867900003703 Predicted transcriptional regulators [Transcription]; Region: COG1695 867900003704 Transcriptional regulator PadR-like family; Region: PadR; cl17335 867900003705 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 867900003706 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 867900003707 Walker A/P-loop; other site 867900003708 ATP binding site [chemical binding]; other site 867900003709 Q-loop/lid; other site 867900003710 ABC transporter signature motif; other site 867900003711 Walker B; other site 867900003712 D-loop; other site 867900003713 H-loop/switch region; other site 867900003714 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900003715 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 867900003716 ATP synthase A chain; Region: ATP-synt_A; cl00413 867900003717 ATP synthase subunit C; Region: ATP-synt_C; cl00466 867900003718 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471 867900003719 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 867900003720 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 867900003721 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 867900003722 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 867900003723 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 867900003724 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 867900003725 beta subunit interaction interface [polypeptide binding]; other site 867900003726 Walker A motif; other site 867900003727 ATP binding site [chemical binding]; other site 867900003728 Walker B motif; other site 867900003729 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 867900003730 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 867900003731 core domain interface [polypeptide binding]; other site 867900003732 delta subunit interface [polypeptide binding]; other site 867900003733 epsilon subunit interface [polypeptide binding]; other site 867900003734 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 867900003735 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 867900003736 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 867900003737 trimer interface [polypeptide binding]; other site 867900003738 active site 867900003739 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 867900003740 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 867900003741 active site 867900003742 Substrate binding site; other site 867900003743 Mg++ binding site; other site 867900003744 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 867900003745 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 867900003746 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 867900003747 ligand binding site [chemical binding]; other site 867900003748 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 867900003749 proline aminopeptidase P II; Provisional; Region: PRK10879 867900003750 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 867900003751 active site 867900003752 VPS10 domain; Region: VPS10; smart00602 867900003753 VPS10 domain; Region: VPS10; smart00602 867900003754 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 867900003755 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 867900003756 Predicted deacylase [General function prediction only]; Region: COG3608 867900003757 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 867900003758 putative active site [active] 867900003759 Zn binding site [ion binding]; other site 867900003760 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 867900003761 ATP-grasp domain; Region: ATP-grasp_4; cl17255 867900003762 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 867900003763 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 867900003764 distal heme binding site [chemical binding]; other site 867900003765 proximal heme binding site [chemical binding]; other site 867900003766 putative dimer interface [polypeptide binding]; other site 867900003767 putative Iron-sulfur protein interface [polypeptide binding]; other site 867900003768 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 867900003769 L-aspartate oxidase; Provisional; Region: PRK06175 867900003770 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 867900003771 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 867900003772 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 867900003773 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 867900003774 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 867900003775 catalytic residues [active] 867900003776 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 867900003777 Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protei; Region: 3a01203; TIGR00954 867900003778 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 867900003779 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 867900003780 Transglycosylase; Region: Transgly; pfam00912 867900003781 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 867900003782 GldH lipoprotein; Region: GldH_lipo; pfam14109 867900003783 PSP1 C-terminal conserved region; Region: PSP1; cl00770 867900003784 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 867900003785 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 867900003786 active site residue [active] 867900003787 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 867900003788 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 867900003789 hexamer interface [polypeptide binding]; other site 867900003790 Walker A motif; other site 867900003791 ATP binding site [chemical binding]; other site 867900003792 Walker B motif; other site 867900003793 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 867900003794 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 867900003795 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 867900003796 DNA binding residues [nucleotide binding] 867900003797 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 867900003798 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 867900003799 putative acyl-acceptor binding pocket; other site 867900003800 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 867900003801 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 867900003802 active site 867900003803 HIGH motif; other site 867900003804 dimer interface [polypeptide binding]; other site 867900003805 KMSKS motif; other site 867900003806 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 867900003807 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 867900003808 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 867900003809 DNA protecting protein DprA; Region: dprA; TIGR00732 867900003810 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 867900003811 Sporulation related domain; Region: SPOR; pfam05036 867900003812 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 867900003813 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 867900003814 classical (c) SDRs; Region: SDR_c; cd05233 867900003815 NAD(P) binding site [chemical binding]; other site 867900003816 active site 867900003817 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 867900003818 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 867900003819 short chain dehydrogenase; Provisional; Region: PRK05993 867900003820 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 867900003821 NAD(P) binding site [chemical binding]; other site 867900003822 active site 867900003823 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 867900003824 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 867900003825 Uncharacterized conserved protein [Function unknown]; Region: COG1359 867900003826 Predicted membrane protein [Function unknown]; Region: COG2855 867900003827 Transcriptional regulator [Transcription]; Region: LysR; COG0583 867900003828 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 867900003829 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 867900003830 putative dimerization interface [polypeptide binding]; other site 867900003831 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 867900003832 Helix-turn-helix domain; Region: HTH_18; pfam12833 867900003833 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 867900003834 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 867900003835 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 867900003836 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 867900003837 classical (c) SDRs; Region: SDR_c; cd05233 867900003838 NAD(P) binding site [chemical binding]; other site 867900003839 active site 867900003840 Cache domain; Region: Cache_1; pfam02743 867900003841 Histidine kinase; Region: His_kinase; pfam06580 867900003842 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 867900003843 active site 867900003844 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 867900003845 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900003846 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 867900003847 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 867900003848 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900003849 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 867900003850 starch binding outer membrane protein SusD; Region: SusD; cd08977 867900003851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900003852 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 867900003853 active site 867900003854 phosphorylation site [posttranslational modification] 867900003855 intermolecular recognition site; other site 867900003856 dimerization interface [polypeptide binding]; other site 867900003857 LytTr DNA-binding domain; Region: LytTR; smart00850 867900003858 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 867900003859 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 867900003860 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 867900003861 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 867900003862 NADH(P)-binding; Region: NAD_binding_10; pfam13460 867900003863 NAD(P) binding site [chemical binding]; other site 867900003864 active site 867900003865 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 867900003866 Helix-turn-helix domain; Region: HTH_18; pfam12833 867900003867 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 867900003868 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 867900003869 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 867900003870 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 867900003871 NAD(P) binding site [chemical binding]; other site 867900003872 catalytic residues [active] 867900003873 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 867900003874 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 867900003875 RDD family; Region: RDD; pfam06271 867900003876 TPR repeat; Region: TPR_11; pfam13414 867900003877 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900003878 binding surface 867900003879 TPR motif; other site 867900003880 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 867900003881 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 867900003882 Family of unknown function (DUF695); Region: DUF695; pfam05117 867900003883 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 867900003884 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 867900003885 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 867900003886 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 867900003887 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 867900003888 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 867900003889 putative active site [active] 867900003890 catalytic site [active] 867900003891 putative metal binding site [ion binding]; other site 867900003892 oligomer interface [polypeptide binding]; other site 867900003893 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 867900003894 Beta-lactamase; Region: Beta-lactamase; pfam00144 867900003895 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 867900003896 Helix-turn-helix domain; Region: HTH_18; pfam12833 867900003897 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 867900003898 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 867900003899 CHAP domain; Region: CHAP; pfam05257 867900003900 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 867900003901 hydrophobic ligand binding site; other site 867900003902 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 867900003903 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 867900003904 ligand binding site [chemical binding]; other site 867900003905 flexible hinge region; other site 867900003906 Repair protein; Region: Repair_PSII; pfam04536 867900003907 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 867900003908 unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional; Region: PRK14966 867900003909 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 867900003910 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 867900003911 Protein of unknown function (DUF3732); Region: DUF3732; pfam12532 867900003912 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 867900003913 integron integrase; Region: integrase_gron; TIGR02249 867900003914 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 867900003915 active site 867900003916 DNA binding site [nucleotide binding] 867900003917 Int/Topo IB signature motif; other site 867900003918 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 867900003919 Peptidase family M23; Region: Peptidase_M23; pfam01551 867900003920 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 867900003921 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 867900003922 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 867900003923 thiamine-monophosphate kinase; Region: thiL; TIGR01379 867900003924 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 867900003925 ATP binding site [chemical binding]; other site 867900003926 dimerization interface [polypeptide binding]; other site 867900003927 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 867900003928 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 867900003929 putative ABC transporter; Region: ycf24; CHL00085 867900003930 FeS assembly ATPase SufC; Region: sufC; TIGR01978 867900003931 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 867900003932 Walker A/P-loop; other site 867900003933 ATP binding site [chemical binding]; other site 867900003934 Q-loop/lid; other site 867900003935 ABC transporter signature motif; other site 867900003936 Walker B; other site 867900003937 D-loop; other site 867900003938 H-loop/switch region; other site 867900003939 FeS assembly protein SufD; Region: sufD; TIGR01981 867900003940 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 867900003941 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 867900003942 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 867900003943 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 867900003944 catalytic residue [active] 867900003945 Fe-S metabolism associated domain; Region: SufE; cl00951 867900003946 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 867900003947 Protein of unknown function (DUF2480); Region: DUF2480; pfam10652 867900003948 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 867900003949 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 867900003950 putative NAD(P) binding site [chemical binding]; other site 867900003951 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 867900003952 M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1; Region: M28_Fxna_like; cd03875 867900003953 Peptidase family M28; Region: Peptidase_M28; pfam04389 867900003954 metal binding site [ion binding]; metal-binding site 867900003955 FOG: CBS domain [General function prediction only]; Region: COG0517 867900003956 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629 867900003957 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 867900003958 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 867900003959 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 867900003960 Leucine-rich repeats, typical (most populated) subfamily; Region: LRR_TYP; cl15310 867900003961 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 867900003962 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 867900003963 YaaC-like Protein; Region: YaaC; pfam14175 867900003964 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 867900003965 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 867900003966 active site 867900003967 metal binding site [ion binding]; metal-binding site 867900003968 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 867900003969 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 867900003970 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 867900003971 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 867900003972 Asp-box motif; other site 867900003973 VPS10 domain; Region: VPS10; smart00602 867900003974 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 867900003975 ferrochelatase; Reviewed; Region: hemH; PRK00035 867900003976 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 867900003977 C-terminal domain interface [polypeptide binding]; other site 867900003978 active site 867900003979 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 867900003980 active site 867900003981 N-terminal domain interface [polypeptide binding]; other site 867900003982 TraB family; Region: TraB; pfam01963 867900003983 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 867900003984 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 867900003985 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 867900003986 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 867900003987 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 867900003988 tRNA; other site 867900003989 putative tRNA binding site [nucleotide binding]; other site 867900003990 putative NADP binding site [chemical binding]; other site 867900003991 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 867900003992 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 867900003993 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 867900003994 domain interfaces; other site 867900003995 active site 867900003996 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 867900003997 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 867900003998 active site 867900003999 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 867900004000 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 867900004001 substrate binding site [chemical binding]; other site 867900004002 active site 867900004003 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 867900004004 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 867900004005 putative substrate binding pocket [chemical binding]; other site 867900004006 trimer interface [polypeptide binding]; other site 867900004007 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 867900004008 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 867900004009 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 867900004010 Fasciclin domain; Region: Fasciclin; pfam02469 867900004011 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 867900004012 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 867900004013 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 867900004014 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 867900004015 Zn binding site [ion binding]; other site 867900004016 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 867900004017 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 867900004018 Walker A/P-loop; other site 867900004019 ATP binding site [chemical binding]; other site 867900004020 Q-loop/lid; other site 867900004021 ABC transporter signature motif; other site 867900004022 Walker B; other site 867900004023 D-loop; other site 867900004024 H-loop/switch region; other site 867900004025 DEAD-like helicases superfamily; Region: DEXDc; smart00487 867900004026 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 867900004027 ATP binding site [chemical binding]; other site 867900004028 putative Mg++ binding site [ion binding]; other site 867900004029 helicase superfamily c-terminal domain; Region: HELICc; smart00490 867900004030 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 867900004031 dimer interface [polypeptide binding]; other site 867900004032 allosteric magnesium binding site [ion binding]; other site 867900004033 active site 867900004034 aspartate-rich active site metal binding site; other site 867900004035 Schiff base residues; other site 867900004036 Domain of unknown function (DUF303); Region: DUF303; pfam03629 867900004037 Helix-turn-helix domain; Region: HTH_18; pfam12833 867900004038 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 867900004039 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 867900004040 Domain of unknown function DUF21; Region: DUF21; pfam01595 867900004041 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 867900004042 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 867900004043 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 867900004044 DNA binding site [nucleotide binding] 867900004045 active site 867900004046 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 867900004047 active site 867900004048 catalytic site [active] 867900004049 substrate binding site [chemical binding]; other site 867900004050 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 867900004051 putative catalytic site [active] 867900004052 putative metal binding site [ion binding]; other site 867900004053 putative phosphate binding site [ion binding]; other site 867900004054 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 867900004055 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 867900004056 HflX GTPase family; Region: HflX; cd01878 867900004057 G1 box; other site 867900004058 GTP/Mg2+ binding site [chemical binding]; other site 867900004059 Switch I region; other site 867900004060 G2 box; other site 867900004061 G3 box; other site 867900004062 Switch II region; other site 867900004063 G4 box; other site 867900004064 G5 box; other site 867900004065 SnoaL-like domain; Region: SnoaL_3; pfam13474 867900004066 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 867900004067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 867900004068 NAD(P) binding site [chemical binding]; other site 867900004069 active site 867900004070 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 867900004071 trimer interface [polypeptide binding]; other site 867900004072 dimer interface [polypeptide binding]; other site 867900004073 putative active site [active] 867900004074 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 867900004075 MoaE homodimer interface [polypeptide binding]; other site 867900004076 MoaD interaction [polypeptide binding]; other site 867900004077 active site residues [active] 867900004078 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 867900004079 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 867900004080 active site 867900004081 Zn binding site [ion binding]; other site 867900004082 Penicillinase repressor; Region: Pencillinase_R; pfam03965 867900004083 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 867900004084 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 867900004085 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 867900004086 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 867900004087 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 867900004088 catalytic residues [active] 867900004089 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 867900004090 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 867900004091 NAD(P) binding site [chemical binding]; other site 867900004092 catalytic residues [active] 867900004093 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 867900004094 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 867900004095 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 867900004096 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 867900004097 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 867900004098 FtsX-like permease family; Region: FtsX; pfam02687 867900004099 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 867900004100 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 867900004101 Walker A/P-loop; other site 867900004102 ATP binding site [chemical binding]; other site 867900004103 Q-loop/lid; other site 867900004104 ABC transporter signature motif; other site 867900004105 Walker B; other site 867900004106 D-loop; other site 867900004107 H-loop/switch region; other site 867900004108 mechanosensitive channel MscS; Provisional; Region: PRK10334 867900004109 Conserved TM helix; Region: TM_helix; pfam05552 867900004110 Mechanosensitive ion channel; Region: MS_channel; pfam00924 867900004111 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 867900004112 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 867900004113 dimerization interface [polypeptide binding]; other site 867900004114 DPS ferroxidase diiron center [ion binding]; other site 867900004115 ion pore; other site 867900004116 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 867900004117 NAD(P) binding site [chemical binding]; other site 867900004118 catalytic residues [active] 867900004119 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 867900004120 protein binding site [polypeptide binding]; other site 867900004121 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 867900004122 Catalytic dyad [active] 867900004123 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 867900004124 catalytic motif [active] 867900004125 Zn binding site [ion binding]; other site 867900004126 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 867900004127 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 867900004128 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 867900004129 putative metal binding site [ion binding]; other site 867900004130 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 867900004131 HSP70 interaction site [polypeptide binding]; other site 867900004132 Disulphide isomerase; Region: Disulph_isomer; pfam06491 867900004133 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 867900004134 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 867900004135 putative acyl-acceptor binding pocket; other site 867900004136 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 867900004137 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 867900004138 Zn2+ binding site [ion binding]; other site 867900004139 Mg2+ binding site [ion binding]; other site 867900004140 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 867900004141 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 867900004142 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 867900004143 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 867900004144 catalytic residues [active] 867900004145 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 867900004146 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 867900004147 FeS/SAM binding site; other site 867900004148 putative transporter; Provisional; Region: PRK10484 867900004149 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 867900004150 Na binding site [ion binding]; other site 867900004151 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 867900004152 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 867900004153 Penicillinase repressor; Region: Pencillinase_R; pfam03965 867900004154 hypothetical protein; Provisional; Region: PRK08201 867900004155 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 867900004156 metal binding site [ion binding]; metal-binding site 867900004157 putative dimer interface [polypeptide binding]; other site 867900004158 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 867900004159 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 867900004160 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 867900004161 HlyD family secretion protein; Region: HlyD_3; pfam13437 867900004162 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 867900004163 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 867900004164 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 867900004165 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 867900004166 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 867900004167 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 867900004168 inhibitor-cofactor binding pocket; inhibition site 867900004169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 867900004170 catalytic residue [active] 867900004171 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 867900004172 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 867900004173 NAD binding site [chemical binding]; other site 867900004174 homodimer interface [polypeptide binding]; other site 867900004175 active site 867900004176 substrate binding site [chemical binding]; other site 867900004177 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 867900004178 HAMP domain; Region: HAMP; pfam00672 867900004179 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 867900004180 dimer interface [polypeptide binding]; other site 867900004181 phosphorylation site [posttranslational modification] 867900004182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900004183 ATP binding site [chemical binding]; other site 867900004184 Mg2+ binding site [ion binding]; other site 867900004185 G-X-G motif; other site 867900004186 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 867900004187 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 867900004188 substrate binding site [chemical binding]; other site 867900004189 oxyanion hole (OAH) forming residues; other site 867900004190 trimer interface [polypeptide binding]; other site 867900004191 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 867900004192 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 867900004193 active site 867900004194 metal binding site [ion binding]; metal-binding site 867900004195 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 867900004196 Zn2+ binding site [ion binding]; other site 867900004197 Mg2+ binding site [ion binding]; other site 867900004198 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 867900004199 putative active site [active] 867900004200 putative metal binding site [ion binding]; other site 867900004201 Helix-turn-helix domain; Region: HTH_17; pfam12728 867900004202 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 867900004203 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 867900004204 cofactor binding site; other site 867900004205 DNA binding site [nucleotide binding] 867900004206 substrate interaction site [chemical binding]; other site 867900004207 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 867900004208 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 867900004209 G1 box; other site 867900004210 GTP/Mg2+ binding site [chemical binding]; other site 867900004211 Switch I region; other site 867900004212 G2 box; other site 867900004213 G3 box; other site 867900004214 Switch II region; other site 867900004215 G4 box; other site 867900004216 G5 box; other site 867900004217 Nucleoside recognition; Region: Gate; pfam07670 867900004218 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 867900004219 Nucleoside recognition; Region: Gate; pfam07670 867900004220 FeoA domain; Region: FeoA; pfam04023 867900004221 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 867900004222 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 867900004223 Cu(I) binding site [ion binding]; other site 867900004224 RIP metalloprotease RseP; Region: TIGR00054 867900004225 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 867900004226 active site 867900004227 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 867900004228 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 867900004229 protein binding site [polypeptide binding]; other site 867900004230 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 867900004231 putative substrate binding region [chemical binding]; other site 867900004232 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 867900004233 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 867900004234 Sulfatase; Region: Sulfatase; cl17466 867900004235 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 867900004236 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900004237 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 867900004238 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900004239 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 867900004240 starch binding outer membrane protein SusD; Region: SusD; cd08977 867900004241 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 867900004242 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900004243 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 867900004244 N-terminal plug; other site 867900004245 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 867900004246 ligand-binding site [chemical binding]; other site 867900004247 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 867900004248 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 867900004249 dimer interface [polypeptide binding]; other site 867900004250 anticodon binding site; other site 867900004251 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 867900004252 homodimer interface [polypeptide binding]; other site 867900004253 motif 1; other site 867900004254 active site 867900004255 motif 2; other site 867900004256 GAD domain; Region: GAD; pfam02938 867900004257 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 867900004258 active site 867900004259 motif 3; other site 867900004260 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 867900004261 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 867900004262 Cl- selectivity filter; other site 867900004263 Cl- binding residues [ion binding]; other site 867900004264 pore gating glutamate residue; other site 867900004265 dimer interface [polypeptide binding]; other site 867900004266 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 867900004267 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 867900004268 DNA-binding site [nucleotide binding]; DNA binding site 867900004269 RNA-binding motif; other site 867900004270 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 867900004271 nucleoside/Zn binding site; other site 867900004272 dimer interface [polypeptide binding]; other site 867900004273 catalytic motif [active] 867900004274 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 867900004275 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 867900004276 TPP-binding site; other site 867900004277 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 867900004278 PYR/PP interface [polypeptide binding]; other site 867900004279 dimer interface [polypeptide binding]; other site 867900004280 TPP binding site [chemical binding]; other site 867900004281 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 867900004282 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 867900004283 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 867900004284 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 867900004285 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 867900004286 Phosphate transporter family; Region: PHO4; pfam01384 867900004287 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 867900004288 active site 867900004289 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 867900004290 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 867900004291 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 867900004292 active site 867900004293 (T/H)XGH motif; other site 867900004294 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 867900004295 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 867900004296 catalytic site [active] 867900004297 G-X2-G-X-G-K; other site 867900004298 hypothetical protein; Provisional; Region: PRK11820 867900004299 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 867900004300 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 867900004301 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 867900004302 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 867900004303 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 867900004304 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 867900004305 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 867900004306 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 867900004307 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 867900004308 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 867900004309 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 867900004310 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 867900004311 Predicted oxidoreductase [General function prediction only]; Region: COG3573 867900004312 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 867900004313 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 867900004314 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 867900004315 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 867900004316 ATP cone domain; Region: ATP-cone; pfam03477 867900004317 Class I ribonucleotide reductase; Region: RNR_I; cd01679 867900004318 active site 867900004319 dimer interface [polypeptide binding]; other site 867900004320 catalytic residues [active] 867900004321 effector binding site; other site 867900004322 R2 peptide binding site; other site 867900004323 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 867900004324 dimer interface [polypeptide binding]; other site 867900004325 putative radical transfer pathway; other site 867900004326 diiron center [ion binding]; other site 867900004327 tyrosyl radical; other site 867900004328 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 867900004329 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900004330 active site 867900004331 phosphorylation site [posttranslational modification] 867900004332 intermolecular recognition site; other site 867900004333 dimerization interface [polypeptide binding]; other site 867900004334 LytTr DNA-binding domain; Region: LytTR; smart00850 867900004335 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900004336 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900004337 binding surface 867900004338 TPR motif; other site 867900004339 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900004340 TPR repeat; Region: TPR_11; pfam13414 867900004341 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900004342 binding surface 867900004343 TPR motif; other site 867900004344 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900004345 Histidine kinase; Region: His_kinase; pfam06580 867900004346 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 867900004347 ATP binding site [chemical binding]; other site 867900004348 Mg2+ binding site [ion binding]; other site 867900004349 G-X-G motif; other site 867900004350 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 867900004351 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 867900004352 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 867900004353 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 867900004354 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 867900004355 HlyD family secretion protein; Region: HlyD_3; pfam13437 867900004356 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 867900004357 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 867900004358 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 867900004359 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 867900004360 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 867900004361 substrate binding pocket [chemical binding]; other site 867900004362 chain length determination region; other site 867900004363 substrate-Mg2+ binding site; other site 867900004364 catalytic residues [active] 867900004365 aspartate-rich region 1; other site 867900004366 active site lid residues [active] 867900004367 aspartate-rich region 2; other site 867900004368 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 867900004369 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900004370 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 867900004371 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 867900004372 N-terminal plug; other site 867900004373 ligand-binding site [chemical binding]; other site 867900004374 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 867900004375 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 867900004376 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 867900004377 FeoA domain; Region: FeoA; pfam04023 867900004378 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 867900004379 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 867900004380 intersubunit interface [polypeptide binding]; other site 867900004381 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 867900004382 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 867900004383 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 867900004384 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 867900004385 ABC-ATPase subunit interface; other site 867900004386 dimer interface [polypeptide binding]; other site 867900004387 putative PBP binding regions; other site 867900004388 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 867900004389 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 867900004390 ABC-ATPase subunit interface; other site 867900004391 dimer interface [polypeptide binding]; other site 867900004392 putative PBP binding regions; other site 867900004393 Protein of unknown function (DUF423); Region: DUF423; pfam04241 867900004394 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900004395 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 867900004396 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 867900004397 active site 867900004398 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 867900004399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 867900004400 S-adenosylmethionine binding site [chemical binding]; other site 867900004401 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 867900004402 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 867900004403 active site 867900004404 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 867900004405 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 867900004406 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 867900004407 active site 867900004408 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 867900004409 nudix motif; other site 867900004410 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 867900004411 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 867900004412 RimM N-terminal domain; Region: RimM; pfam01782 867900004413 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521 867900004414 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 867900004415 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 867900004416 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 867900004417 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 867900004418 active site 867900004419 catalytic site [active] 867900004420 substrate binding site [chemical binding]; other site 867900004421 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 867900004422 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 867900004423 active site 867900004424 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 867900004425 generic binding surface I; other site 867900004426 generic binding surface II; other site 867900004427 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900004428 Kelch motif; Region: Kelch_1; pfam01344 867900004429 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 867900004430 active site 867900004431 catalytic site [active] 867900004432 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 867900004433 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 867900004434 short chain dehydrogenase; Provisional; Region: PRK06197 867900004435 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 867900004436 putative NAD(P) binding site [chemical binding]; other site 867900004437 active site 867900004438 Leucine rich repeat; Region: LRR_8; pfam13855 867900004439 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 867900004440 Domain of unknown function (DUF4297); Region: DUF4297; pfam14130 867900004441 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 867900004442 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 867900004443 dimer interface [polypeptide binding]; other site 867900004444 ssDNA binding site [nucleotide binding]; other site 867900004445 tetramer (dimer of dimers) interface [polypeptide binding]; other site 867900004446 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 867900004447 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 867900004448 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 867900004449 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 867900004450 RNA binding site [nucleotide binding]; other site 867900004451 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 867900004452 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 867900004453 ligand binding site [chemical binding]; other site 867900004454 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 867900004455 Ferritin-like domain; Region: Ferritin; pfam00210 867900004456 ferroxidase diiron center [ion binding]; other site 867900004457 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 867900004458 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 867900004459 active site 867900004460 HIGH motif; other site 867900004461 KMSKS motif; other site 867900004462 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 867900004463 tRNA binding surface [nucleotide binding]; other site 867900004464 anticodon binding site; other site 867900004465 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 867900004466 dimer interface [polypeptide binding]; other site 867900004467 putative tRNA-binding site [nucleotide binding]; other site 867900004468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 867900004469 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 867900004470 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 867900004471 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 867900004472 Family description; Region: ACT_7; pfam13840 867900004473 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 867900004474 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 867900004475 catalytic residues [active] 867900004476 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 867900004477 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 867900004478 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 867900004479 ATP binding site [chemical binding]; other site 867900004480 putative Mg++ binding site [ion binding]; other site 867900004481 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 867900004482 nucleotide binding region [chemical binding]; other site 867900004483 ATP-binding site [chemical binding]; other site 867900004484 TRCF domain; Region: TRCF; pfam03461 867900004485 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900004486 GLPGLI family protein; Region: GLPGLI; TIGR01200 867900004487 Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903 867900004488 Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903 867900004489 GLPGLI family protein; Region: GLPGLI; TIGR01200 867900004490 GLPGLI family protein; Region: GLPGLI; TIGR01200 867900004491 Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903 867900004492 tellurium resistance terB-like protein; Region: terB_like; cd07177 867900004493 metal binding site [ion binding]; metal-binding site 867900004494 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 867900004495 AMP binding site [chemical binding]; other site 867900004496 metal binding site [ion binding]; metal-binding site 867900004497 active site 867900004498 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 867900004499 Coenzyme A binding pocket [chemical binding]; other site 867900004500 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 867900004501 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 867900004502 nucleotide binding site [chemical binding]; other site 867900004503 substrate binding site [chemical binding]; other site 867900004504 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 867900004505 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 867900004506 putative acyl-acceptor binding pocket; other site 867900004507 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 867900004508 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900004509 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 867900004510 active site 867900004511 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 867900004512 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 867900004513 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_14; cd12179 867900004514 putative ligand binding site [chemical binding]; other site 867900004515 putative NAD binding site [chemical binding]; other site 867900004516 catalytic site [active] 867900004517 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 867900004518 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 867900004519 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 867900004520 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 867900004521 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 867900004522 histidine decarboxylase; Provisional; Region: PRK02769 867900004523 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 867900004524 catalytic residue [active] 867900004525 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 867900004526 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 867900004527 putative DNA binding site [nucleotide binding]; other site 867900004528 putative Zn2+ binding site [ion binding]; other site 867900004529 AsnC family; Region: AsnC_trans_reg; pfam01037 867900004530 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 867900004531 MgtE intracellular N domain; Region: MgtE_N; pfam03448 867900004532 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 867900004533 Divalent cation transporter; Region: MgtE; pfam01769 867900004534 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 867900004535 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 867900004536 S-adenosylmethionine binding site [chemical binding]; other site 867900004537 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 867900004538 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900004539 TPR motif; other site 867900004540 binding surface 867900004541 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900004542 binding surface 867900004543 TPR motif; other site 867900004544 seryl-tRNA synthetase; Provisional; Region: PRK05431 867900004545 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 867900004546 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 867900004547 dimer interface [polypeptide binding]; other site 867900004548 active site 867900004549 motif 1; other site 867900004550 motif 2; other site 867900004551 motif 3; other site 867900004552 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 867900004553 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 867900004554 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 867900004555 active site 867900004556 Riboflavin kinase; Region: Flavokinase; pfam01687 867900004557 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 867900004558 putative active site [active] 867900004559 catalytic residue [active] 867900004560 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 867900004561 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 867900004562 5S rRNA interface [nucleotide binding]; other site 867900004563 CTC domain interface [polypeptide binding]; other site 867900004564 L16 interface [polypeptide binding]; other site 867900004565 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 867900004566 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 867900004567 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 867900004568 active site 867900004569 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 867900004570 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 867900004571 homotrimer interaction site [polypeptide binding]; other site 867900004572 putative active site [active] 867900004573 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 867900004574 VanW like protein; Region: VanW; pfam04294 867900004575 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 867900004576 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 867900004577 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 867900004578 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 867900004579 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 867900004580 GAF domain; Region: GAF; pfam01590 867900004581 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 867900004582 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 867900004583 dimer interface [polypeptide binding]; other site 867900004584 phosphorylation site [posttranslational modification] 867900004585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900004586 ATP binding site [chemical binding]; other site 867900004587 Mg2+ binding site [ion binding]; other site 867900004588 G-X-G motif; other site 867900004589 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900004590 TPR motif; other site 867900004591 binding surface 867900004592 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900004593 binding surface 867900004594 TPR motif; other site 867900004595 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 867900004596 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 867900004597 Sulfatase; Region: Sulfatase; pfam00884 867900004598 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900004599 starch binding outer membrane protein SusD; Region: SusD; cd08977 867900004600 SusD family; Region: SusD; pfam07980 867900004601 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 867900004602 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900004603 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 867900004604 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 867900004605 Sulfatase; Region: Sulfatase; pfam00884 867900004606 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 867900004607 Sulfatase; Region: Sulfatase; cl17466 867900004608 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 867900004609 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 867900004610 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 867900004611 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 867900004612 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 867900004613 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 867900004614 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 867900004615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 867900004616 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 867900004617 Sulfatase; Region: Sulfatase; pfam00884 867900004618 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 867900004619 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 867900004620 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 867900004621 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 867900004622 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 867900004623 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 867900004624 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 867900004625 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 867900004626 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 867900004627 active site 867900004628 intersubunit interface [polypeptide binding]; other site 867900004629 catalytic residue [active] 867900004630 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 867900004631 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 867900004632 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 867900004633 tetramerization interface [polypeptide binding]; other site 867900004634 NAD(P) binding site [chemical binding]; other site 867900004635 catalytic residues [active] 867900004636 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 867900004637 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 867900004638 active site pocket [active] 867900004639 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 867900004640 fructuronate transporter; Provisional; Region: PRK10034; cl15264 867900004641 GntP family permease; Region: GntP_permease; pfam02447 867900004642 Cupin domain; Region: Cupin_2; cl17218 867900004643 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 867900004644 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 867900004645 active site 867900004646 putative DNA-binding cleft [nucleotide binding]; other site 867900004647 dimer interface [polypeptide binding]; other site 867900004648 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 867900004649 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 867900004650 FeS/SAM binding site; other site 867900004651 HemN C-terminal domain; Region: HemN_C; pfam06969 867900004652 Putative cyclase; Region: Cyclase; pfam04199 867900004653 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 867900004654 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 867900004655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 867900004656 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 867900004657 Walker A/P-loop; other site 867900004658 ATP binding site [chemical binding]; other site 867900004659 Q-loop/lid; other site 867900004660 ABC transporter signature motif; other site 867900004661 Walker B; other site 867900004662 D-loop; other site 867900004663 H-loop/switch region; other site 867900004664 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 867900004665 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 867900004666 TPP-binding site [chemical binding]; other site 867900004667 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 867900004668 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 867900004669 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 867900004670 E3 interaction surface; other site 867900004671 lipoyl attachment site [posttranslational modification]; other site 867900004672 e3 binding domain; Region: E3_binding; pfam02817 867900004673 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 867900004674 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 867900004675 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 867900004676 catalytic motif [active] 867900004677 Catalytic residue [active] 867900004678 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 867900004679 active site 867900004680 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 867900004681 active site 867900004682 homodimer interface [polypeptide binding]; other site 867900004683 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 867900004684 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 867900004685 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 867900004686 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 867900004687 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 867900004688 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 867900004689 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 867900004690 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 867900004691 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 867900004692 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 867900004693 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 867900004694 putative dimer interface [polypeptide binding]; other site 867900004695 putative anticodon binding site; other site 867900004696 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 867900004697 homodimer interface [polypeptide binding]; other site 867900004698 motif 1; other site 867900004699 motif 2; other site 867900004700 active site 867900004701 motif 3; other site 867900004702 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 867900004703 Protein export membrane protein; Region: SecD_SecF; cl14618 867900004704 ribosome recycling factor; Reviewed; Region: frr; PRK00083 867900004705 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 867900004706 hinge region; other site 867900004707 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 867900004708 putative nucleotide binding site [chemical binding]; other site 867900004709 uridine monophosphate binding site [chemical binding]; other site 867900004710 homohexameric interface [polypeptide binding]; other site 867900004711 elongation factor Ts; Provisional; Region: tsf; PRK09377 867900004712 UBA/TS-N domain; Region: UBA; pfam00627 867900004713 Elongation factor TS; Region: EF_TS; pfam00889 867900004714 Elongation factor TS; Region: EF_TS; pfam00889 867900004715 30S ribosomal protein S2/unknown domain fusion protein; Provisional; Region: rpsB; PRK12311 867900004716 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 867900004717 rRNA interaction site [nucleotide binding]; other site 867900004718 S8 interaction site; other site 867900004719 putative laminin-1 binding site; other site 867900004720 Uncharacterized conserved protein [Function unknown]; Region: COG3743 867900004721 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 867900004722 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 867900004723 23S rRNA interface [nucleotide binding]; other site 867900004724 L3 interface [polypeptide binding]; other site 867900004725 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 867900004726 putative ligand binding site [chemical binding]; other site 867900004727 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 867900004728 DNA polymerase I; Provisional; Region: PRK05755 867900004729 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 867900004730 active site 867900004731 metal binding site 1 [ion binding]; metal-binding site 867900004732 putative 5' ssDNA interaction site; other site 867900004733 metal binding site 3; metal-binding site 867900004734 metal binding site 2 [ion binding]; metal-binding site 867900004735 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 867900004736 putative DNA binding site [nucleotide binding]; other site 867900004737 putative metal binding site [ion binding]; other site 867900004738 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 867900004739 active site 867900004740 catalytic site [active] 867900004741 substrate binding site [chemical binding]; other site 867900004742 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 867900004743 active site 867900004744 DNA binding site [nucleotide binding] 867900004745 catalytic site [active] 867900004746 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 867900004747 active site 867900004748 dimer interface [polypeptide binding]; other site 867900004749 catalytic nucleophile [active] 867900004750 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 867900004751 phosphodiesterase YaeI; Provisional; Region: PRK11340 867900004752 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 867900004753 putative active site [active] 867900004754 putative metal binding site [ion binding]; other site 867900004755 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 867900004756 catalytic residues [active] 867900004757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 867900004758 Predicted permeases [General function prediction only]; Region: COG0730 867900004759 putative substrate translocation pore; other site 867900004760 hypothetical protein; Validated; Region: PRK02001 867900004761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 867900004762 heptamer interface [polypeptide binding]; other site 867900004763 Sm1 motif; other site 867900004764 hexamer interface [polypeptide binding]; other site 867900004765 RNA binding site [nucleotide binding]; other site 867900004766 Sm2 motif; other site 867900004767 transcription termination factor NusA; Region: NusA; TIGR01953 867900004768 NusA N-terminal domain; Region: NusA_N; pfam08529 867900004769 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 867900004770 RNA binding site [nucleotide binding]; other site 867900004771 homodimer interface [polypeptide binding]; other site 867900004772 NusA-like KH domain; Region: KH_5; pfam13184 867900004773 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 867900004774 G-X-X-G motif; other site 867900004775 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 867900004776 translation initiation factor IF-2; Region: IF-2; TIGR00487 867900004777 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 867900004778 G1 box; other site 867900004779 putative GEF interaction site [polypeptide binding]; other site 867900004780 GTP/Mg2+ binding site [chemical binding]; other site 867900004781 Switch I region; other site 867900004782 G2 box; other site 867900004783 G3 box; other site 867900004784 Switch II region; other site 867900004785 G4 box; other site 867900004786 G5 box; other site 867900004787 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 867900004788 Translation-initiation factor 2; Region: IF-2; pfam11987 867900004789 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 867900004790 Sporulation related domain; Region: SPOR; pfam05036 867900004791 Sporulation related domain; Region: SPOR; pfam05036 867900004792 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 867900004793 Cytochrome c; Region: Cytochrom_C; pfam00034 867900004794 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 867900004795 heme-binding residues [chemical binding]; other site 867900004796 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 867900004797 heme-binding residues [chemical binding]; other site 867900004798 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 867900004799 molybdopterin cofactor binding site; other site 867900004800 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 867900004801 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 867900004802 4Fe-4S binding domain; Region: Fer4; cl02805 867900004803 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 867900004804 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 867900004805 Uncharacterized conserved protein [Function unknown]; Region: COG3743 867900004806 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 867900004807 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 867900004808 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 867900004809 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 867900004810 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 867900004811 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 867900004812 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 867900004813 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 867900004814 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 867900004815 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 867900004816 Walker A motif; other site 867900004817 ATP binding site [chemical binding]; other site 867900004818 Walker B motif; other site 867900004819 arginine finger; other site 867900004820 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 867900004821 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 867900004822 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 867900004823 FeS/SAM binding site; other site 867900004824 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 867900004825 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 867900004826 ThiS interaction site; other site 867900004827 putative active site [active] 867900004828 tetramer interface [polypeptide binding]; other site 867900004829 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 867900004830 thiamine phosphate binding site [chemical binding]; other site 867900004831 active site 867900004832 pyrophosphate binding site [ion binding]; other site 867900004833 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 867900004834 thiamine phosphate binding site [chemical binding]; other site 867900004835 active site 867900004836 pyrophosphate binding site [ion binding]; other site 867900004837 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 867900004838 ThiC-associated domain; Region: ThiC-associated; pfam13667 867900004839 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 867900004840 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 867900004841 thiS-thiF/thiG interaction site; other site 867900004842 polyphosphate kinase; Provisional; Region: PRK05443 867900004843 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 867900004844 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 867900004845 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 867900004846 putative active site [active] 867900004847 catalytic site [active] 867900004848 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 867900004849 domain interface [polypeptide binding]; other site 867900004850 active site 867900004851 catalytic site [active] 867900004852 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 867900004853 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 867900004854 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 867900004855 Malic enzyme, N-terminal domain; Region: malic; pfam00390 867900004856 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 867900004857 putative NAD(P) binding site [chemical binding]; other site 867900004858 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 867900004859 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 867900004860 RuvA N terminal domain; Region: RuvA_N; pfam01330 867900004861 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 867900004862 cell surface protein SprA; Region: surface_SprA; TIGR04189 867900004863 Motility related/secretion protein; Region: SprA_N; pfam14349 867900004864 Motility related/secretion protein; Region: SprA_N; pfam14349 867900004865 Motility related/secretion protein; Region: SprA_N; pfam14349 867900004866 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 867900004867 lipoyl attachment site [posttranslational modification]; other site 867900004868 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 867900004869 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 867900004870 protoheme IX farnesyltransferase; Region: cyoE_ctaB; TIGR01473 867900004871 UbiA prenyltransferase family; Region: UbiA; pfam01040 867900004872 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 867900004873 Subunit I/III interface [polypeptide binding]; other site 867900004874 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 867900004875 Subunit I/III interface [polypeptide binding]; other site 867900004876 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 867900004877 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 867900004878 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 867900004879 Cu(I) binding site [ion binding]; other site 867900004880 Protein of unknown function (DUF420); Region: DUF420; pfam04238 867900004881 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 867900004882 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 867900004883 Walker A/P-loop; other site 867900004884 ATP binding site [chemical binding]; other site 867900004885 Q-loop/lid; other site 867900004886 ABC transporter signature motif; other site 867900004887 Walker B; other site 867900004888 D-loop; other site 867900004889 H-loop/switch region; other site 867900004890 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 867900004891 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 867900004892 FtsX-like permease family; Region: FtsX; pfam02687 867900004893 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 867900004894 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 867900004895 FtsX-like permease family; Region: FtsX; pfam02687 867900004896 macrolide transporter subunit MacA; Provisional; Region: PRK11578 867900004897 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 867900004898 HlyD family secretion protein; Region: HlyD_3; pfam13437 867900004899 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 867900004900 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 867900004901 Glycoprotease family; Region: Peptidase_M22; pfam00814 867900004902 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 867900004903 Mechanosensitive ion channel; Region: MS_channel; pfam00924 867900004904 Dodecin; Region: Dodecin; pfam07311 867900004905 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 867900004906 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 867900004907 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 867900004908 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 867900004909 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 867900004910 metal ion-dependent adhesion site (MIDAS); other site 867900004911 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900004912 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900004913 TPR motif; other site 867900004914 binding surface 867900004915 Histidine kinase; Region: His_kinase; pfam06580 867900004916 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 867900004917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900004918 active site 867900004919 phosphorylation site [posttranslational modification] 867900004920 intermolecular recognition site; other site 867900004921 dimerization interface [polypeptide binding]; other site 867900004922 LytTr DNA-binding domain; Region: LytTR; smart00850 867900004923 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 867900004924 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 867900004925 trimer interface [polypeptide binding]; other site 867900004926 putative metal binding site [ion binding]; other site 867900004927 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 867900004928 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 867900004929 Calx-beta domain; Region: Calx-beta; cl02522 867900004930 Domain of unknown function DUF11; Region: DUF11; cl17728 867900004931 Domain of unknown function DUF11; Region: DUF11; pfam01345 867900004932 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 867900004933 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 867900004934 TPR repeat; Region: TPR_11; pfam13414 867900004935 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 867900004936 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 867900004937 ligand binding site [chemical binding]; other site 867900004938 acetyl-CoA synthetase; Provisional; Region: PRK00174 867900004939 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 867900004940 active site 867900004941 CoA binding site [chemical binding]; other site 867900004942 acyl-activating enzyme (AAE) consensus motif; other site 867900004943 AMP binding site [chemical binding]; other site 867900004944 acetate binding site [chemical binding]; other site 867900004945 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 867900004946 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 867900004947 putative active site [active] 867900004948 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 867900004949 active site triad [active] 867900004950 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 867900004951 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 867900004952 AsnC family; Region: AsnC_trans_reg; pfam01037 867900004953 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 867900004954 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 867900004955 THF binding site; other site 867900004956 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 867900004957 substrate binding site [chemical binding]; other site 867900004958 THF binding site; other site 867900004959 zinc-binding site [ion binding]; other site 867900004960 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 867900004961 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 867900004962 active site 867900004963 catalytic triad [active] 867900004964 oxyanion hole [active] 867900004965 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 867900004966 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 867900004967 catalytic residue [active] 867900004968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 867900004969 Major Facilitator Superfamily; Region: MFS_1; pfam07690 867900004970 putative substrate translocation pore; other site 867900004971 Helix-turn-helix domain; Region: HTH_18; pfam12833 867900004972 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 867900004973 Uncharacterized protein domain similar to Clostridium thermocellum 2751; Region: Cthe_2751_like; cd11743 867900004974 dimer interface [polypeptide binding]; other site 867900004975 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 867900004976 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 867900004977 MutS domain I; Region: MutS_I; pfam01624 867900004978 MutS domain II; Region: MutS_II; pfam05188 867900004979 MutS domain III; Region: MutS_III; pfam05192 867900004980 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 867900004981 Walker A/P-loop; other site 867900004982 ATP binding site [chemical binding]; other site 867900004983 Q-loop/lid; other site 867900004984 ABC transporter signature motif; other site 867900004985 Walker B; other site 867900004986 D-loop; other site 867900004987 H-loop/switch region; other site 867900004988 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 867900004989 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 867900004990 catalytic center binding site [active] 867900004991 ATP binding site [chemical binding]; other site 867900004992 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 867900004993 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 867900004994 Substrate-binding site [chemical binding]; other site 867900004995 Substrate specificity [chemical binding]; other site 867900004996 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 867900004997 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 867900004998 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 867900004999 GH3 auxin-responsive promoter; Region: GH3; pfam03321 867900005000 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 867900005001 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 867900005002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 867900005003 Walker A motif; other site 867900005004 ATP binding site [chemical binding]; other site 867900005005 Walker B motif; other site 867900005006 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 867900005007 Clp protease; Region: CLP_protease; pfam00574 867900005008 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 867900005009 oligomer interface [polypeptide binding]; other site 867900005010 active site residues [active] 867900005011 Membrane protein of unknown function; Region: DUF360; pfam04020 867900005012 PGAP1-like protein; Region: PGAP1; pfam07819 867900005013 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 867900005014 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 867900005015 active site 867900005016 hydrophilic channel; other site 867900005017 dimerization interface [polypeptide binding]; other site 867900005018 catalytic residues [active] 867900005019 active site lid [active] 867900005020 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 867900005021 FOG: CBS domain [General function prediction only]; Region: COG0517 867900005022 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01911 867900005023 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 867900005024 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 867900005025 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 867900005026 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 867900005027 catalytic residue [active] 867900005028 putative FPP diphosphate binding site; other site 867900005029 putative FPP binding hydrophobic cleft; other site 867900005030 dimer interface [polypeptide binding]; other site 867900005031 putative IPP diphosphate binding site; other site 867900005032 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 867900005033 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 867900005034 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 867900005035 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 867900005036 Surface antigen; Region: Bac_surface_Ag; pfam01103 867900005037 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 867900005038 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 867900005039 periplasmic chaperone; Provisional; Region: PRK10780 867900005040 glutamate racemase; Provisional; Region: PRK00865 867900005041 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 867900005042 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 867900005043 NADP+ binding site [chemical binding]; other site 867900005044 folate binding site [chemical binding]; other site 867900005045 thymidylate synthase; Reviewed; Region: thyA; PRK01827 867900005046 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 867900005047 dimerization interface [polypeptide binding]; other site 867900005048 active site 867900005049 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 867900005050 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 867900005051 Nucleoside recognition; Region: Gate; pfam07670 867900005052 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 867900005053 Bifunctional nuclease; Region: DNase-RNase; pfam02577 867900005054 UvrB/uvrC motif; Region: UVR; pfam02151 867900005055 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 867900005056 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 867900005057 Ligand Binding Site [chemical binding]; other site 867900005058 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 867900005059 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 867900005060 Ligand binding site [chemical binding]; other site 867900005061 Electron transfer flavoprotein domain; Region: ETF; pfam01012 867900005062 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 867900005063 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 867900005064 alpha subunit interface [polypeptide binding]; other site 867900005065 TPP binding site [chemical binding]; other site 867900005066 heterodimer interface [polypeptide binding]; other site 867900005067 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 867900005068 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900005069 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 867900005070 dimer interface [polypeptide binding]; other site 867900005071 substrate binding site [chemical binding]; other site 867900005072 metal binding sites [ion binding]; metal-binding site 867900005073 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 867900005074 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 867900005075 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 867900005076 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 867900005077 Substrate-binding site [chemical binding]; other site 867900005078 Substrate specificity [chemical binding]; other site 867900005079 GLPGLI family protein; Region: GLPGLI; TIGR01200 867900005080 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 867900005081 S-adenosylmethionine synthetase; Validated; Region: PRK05250 867900005082 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 867900005083 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 867900005084 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 867900005085 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 867900005086 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 867900005087 homodimer interface [polypeptide binding]; other site 867900005088 substrate-cofactor binding pocket; other site 867900005089 pyridoxal 5'-phosphate binding site [chemical binding]; other site 867900005090 catalytic residue [active] 867900005091 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 867900005092 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 867900005093 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 867900005094 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 867900005095 nucleotide binding site [chemical binding]; other site 867900005096 substrate binding site [chemical binding]; other site 867900005097 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 867900005098 dimer interface [polypeptide binding]; other site 867900005099 putative threonine allosteric regulatory site; other site 867900005100 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 867900005101 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 867900005102 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 867900005103 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 867900005104 homodimer interface [polypeptide binding]; other site 867900005105 substrate-cofactor binding pocket; other site 867900005106 pyridoxal 5'-phosphate binding site [chemical binding]; other site 867900005107 catalytic residue [active] 867900005108 Rrf2 family protein; Region: rrf2_super; TIGR00738 867900005109 Transcriptional regulator; Region: Rrf2; pfam02082 867900005110 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 867900005111 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 867900005112 Active Sites [active] 867900005113 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 867900005114 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 867900005115 Active Sites [active] 867900005116 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 867900005117 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 867900005118 CysD dimerization site [polypeptide binding]; other site 867900005119 G1 box; other site 867900005120 putative GEF interaction site [polypeptide binding]; other site 867900005121 GTP/Mg2+ binding site [chemical binding]; other site 867900005122 Switch I region; other site 867900005123 G2 box; other site 867900005124 G3 box; other site 867900005125 Switch II region; other site 867900005126 G4 box; other site 867900005127 G5 box; other site 867900005128 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 867900005129 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 867900005130 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 867900005131 precorrin-3B synthase; Region: CobG; TIGR02435 867900005132 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 867900005133 HEPN domain; Region: HEPN; pfam05168 867900005134 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 867900005135 active site 867900005136 SAM binding site [chemical binding]; other site 867900005137 homodimer interface [polypeptide binding]; other site 867900005138 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 867900005139 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 867900005140 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 867900005141 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 867900005142 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 867900005143 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 867900005144 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 867900005145 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 867900005146 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 867900005147 substrate binding pocket [chemical binding]; other site 867900005148 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 867900005149 B12 binding site [chemical binding]; other site 867900005150 cobalt ligand [ion binding]; other site 867900005151 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 867900005152 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 867900005153 FAD binding site [chemical binding]; other site 867900005154 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 867900005155 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 867900005156 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 867900005157 Beta-lactamase; Region: Beta-lactamase; pfam00144 867900005158 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 867900005159 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 867900005160 Walker A/P-loop; other site 867900005161 ATP binding site [chemical binding]; other site 867900005162 Q-loop/lid; other site 867900005163 ABC transporter signature motif; other site 867900005164 Walker B; other site 867900005165 D-loop; other site 867900005166 H-loop/switch region; other site 867900005167 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 867900005168 Prephenate dehydratase; Region: PDT; pfam00800 867900005169 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 867900005170 putative L-Phe binding site [chemical binding]; other site 867900005171 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 867900005172 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 867900005173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 867900005174 homodimer interface [polypeptide binding]; other site 867900005175 catalytic residue [active] 867900005176 prephenate dehydrogenase; Validated; Region: PRK08507 867900005177 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 867900005178 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 867900005179 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 867900005180 Chorismate mutase type II; Region: CM_2; smart00830 867900005181 GTPase RsgA; Reviewed; Region: PRK00098 867900005182 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 867900005183 RNA binding site [nucleotide binding]; other site 867900005184 homodimer interface [polypeptide binding]; other site 867900005185 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 867900005186 GTPase/Zn-binding domain interface [polypeptide binding]; other site 867900005187 GTP/Mg2+ binding site [chemical binding]; other site 867900005188 G4 box; other site 867900005189 G5 box; other site 867900005190 G1 box; other site 867900005191 Switch I region; other site 867900005192 G2 box; other site 867900005193 G3 box; other site 867900005194 Switch II region; other site 867900005195 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 867900005196 putative active site [active] 867900005197 dimerization interface [polypeptide binding]; other site 867900005198 putative tRNAtyr binding site [nucleotide binding]; other site 867900005199 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 867900005200 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 867900005201 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 867900005202 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 867900005203 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 867900005204 Domain of Unknown Function with PDB structure (DUF3858); Region: DUF3858; pfam12970 867900005205 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 867900005206 homodimer interface [polypeptide binding]; other site 867900005207 metal binding site [ion binding]; metal-binding site 867900005208 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 867900005209 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 867900005210 hinge; other site 867900005211 active site 867900005212 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 867900005213 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 867900005214 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 867900005215 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 867900005216 FeS/SAM binding site; other site 867900005217 Surface lipoprotein of Spirochaetales order; Region: Lipl32; pfam12103 867900005218 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 867900005219 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 867900005220 substrate binding pocket [chemical binding]; other site 867900005221 chain length determination region; other site 867900005222 substrate-Mg2+ binding site; other site 867900005223 catalytic residues [active] 867900005224 aspartate-rich region 1; other site 867900005225 active site lid residues [active] 867900005226 aspartate-rich region 2; other site 867900005227 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 867900005228 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 867900005229 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 867900005230 DNA binding residues [nucleotide binding] 867900005231 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 867900005232 DNA primase, catalytic core; Region: dnaG; TIGR01391 867900005233 CHC2 zinc finger; Region: zf-CHC2; cl17510 867900005234 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 867900005235 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 867900005236 active site 867900005237 metal binding site [ion binding]; metal-binding site 867900005238 interdomain interaction site; other site 867900005239 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 867900005240 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 867900005241 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 867900005242 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 867900005243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900005244 active site 867900005245 phosphorylation site [posttranslational modification] 867900005246 intermolecular recognition site; other site 867900005247 dimerization interface [polypeptide binding]; other site 867900005248 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 867900005249 DNA binding residues [nucleotide binding] 867900005250 dimerization interface [polypeptide binding]; other site 867900005251 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 867900005252 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 867900005253 homodimer interface [polypeptide binding]; other site 867900005254 NAD binding pocket [chemical binding]; other site 867900005255 ATP binding pocket [chemical binding]; other site 867900005256 Mg binding site [ion binding]; other site 867900005257 active-site loop [active] 867900005258 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 867900005259 gliding motility-associated protein GldC; Region: GldC; TIGR03515 867900005260 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900005261 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 867900005262 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900005263 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 867900005264 G1 box; other site 867900005265 GTP/Mg2+ binding site [chemical binding]; other site 867900005266 Switch I region; other site 867900005267 G2 box; other site 867900005268 G3 box; other site 867900005269 Switch II region; other site 867900005270 G4 box; other site 867900005271 G5 box; other site 867900005272 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 867900005273 cell division protein MraZ; Reviewed; Region: PRK00326 867900005274 MraZ protein; Region: MraZ; pfam02381 867900005275 MraZ protein; Region: MraZ; pfam02381 867900005276 MraW methylase family; Region: Methyltransf_5; cl17771 867900005277 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 867900005278 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 867900005279 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 867900005280 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 867900005281 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 867900005282 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 867900005283 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 867900005284 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 867900005285 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 867900005286 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 867900005287 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 867900005288 Mg++ binding site [ion binding]; other site 867900005289 putative catalytic motif [active] 867900005290 putative substrate binding site [chemical binding]; other site 867900005291 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 867900005292 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 867900005293 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 867900005294 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 867900005295 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 867900005296 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 867900005297 active site 867900005298 homodimer interface [polypeptide binding]; other site 867900005299 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 867900005300 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 867900005301 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 867900005302 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 867900005303 cell division protein FtsQ; Provisional; Region: PRK05529 867900005304 cell division protein FtsA; Region: ftsA; TIGR01174 867900005305 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 867900005306 nucleotide binding site [chemical binding]; other site 867900005307 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 867900005308 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 867900005309 Cell division protein FtsA; Region: FtsA; pfam14450 867900005310 cell division protein FtsZ; Validated; Region: PRK09330 867900005311 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 867900005312 nucleotide binding site [chemical binding]; other site 867900005313 SulA interaction site; other site 867900005314 Yqey-like protein; Region: YqeY; cl17540 867900005315 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 867900005316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900005317 active site 867900005318 phosphorylation site [posttranslational modification] 867900005319 intermolecular recognition site; other site 867900005320 dimerization interface [polypeptide binding]; other site 867900005321 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 867900005322 DNA binding residues [nucleotide binding] 867900005323 dimerization interface [polypeptide binding]; other site 867900005324 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900005325 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900005326 TPR motif; other site 867900005327 binding surface 867900005328 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 867900005329 Histidine kinase; Region: HisKA_3; pfam07730 867900005330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900005331 ATP binding site [chemical binding]; other site 867900005332 Mg2+ binding site [ion binding]; other site 867900005333 G-X-G motif; other site 867900005334 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 867900005335 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 867900005336 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 867900005337 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 867900005338 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 867900005339 substrate binding site [chemical binding]; other site 867900005340 hexamer interface [polypeptide binding]; other site 867900005341 metal binding site [ion binding]; metal-binding site 867900005342 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 867900005343 DNA-binding site [nucleotide binding]; DNA binding site 867900005344 RNA-binding motif; other site 867900005345 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 867900005346 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 867900005347 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 867900005348 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 867900005349 active site 867900005350 dimer interface [polypeptide binding]; other site 867900005351 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 867900005352 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 867900005353 active site 867900005354 FMN binding site [chemical binding]; other site 867900005355 substrate binding site [chemical binding]; other site 867900005356 3Fe-4S cluster binding site [ion binding]; other site 867900005357 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 867900005358 domain interface; other site 867900005359 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 867900005360 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 867900005361 FAD binding site [chemical binding]; other site 867900005362 homotetramer interface [polypeptide binding]; other site 867900005363 substrate binding pocket [chemical binding]; other site 867900005364 catalytic base [active] 867900005365 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 867900005366 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 867900005367 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 867900005368 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 867900005369 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 867900005370 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 867900005371 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 867900005372 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 867900005373 Gram-negative bacterial tonB protein; Region: TonB; cl10048 867900005374 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 867900005375 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 867900005376 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 867900005377 glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122 867900005378 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 867900005379 active site 867900005380 trimer interface [polypeptide binding]; other site 867900005381 allosteric site; other site 867900005382 active site lid [active] 867900005383 hexamer (dimer of trimers) interface [polypeptide binding]; other site 867900005384 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 867900005385 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 867900005386 Ligand Binding Site [chemical binding]; other site 867900005387 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 867900005388 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 867900005389 ligand binding site [chemical binding]; other site 867900005390 flexible hinge region; other site 867900005391 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 867900005392 putative switch regulator; other site 867900005393 non-specific DNA interactions [nucleotide binding]; other site 867900005394 DNA binding site [nucleotide binding] 867900005395 sequence specific DNA binding site [nucleotide binding]; other site 867900005396 putative cAMP binding site [chemical binding]; other site 867900005397 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 867900005398 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 867900005399 Heavy-metal-associated domain; Region: HMA; pfam00403 867900005400 metal-binding site [ion binding] 867900005401 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 867900005402 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 867900005403 motif II; other site 867900005404 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 867900005405 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 867900005406 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 867900005407 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 867900005408 Low-spin heme binding site [chemical binding]; other site 867900005409 Putative water exit pathway; other site 867900005410 Binuclear center (active site) [active] 867900005411 Putative proton exit pathway; other site 867900005412 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 867900005413 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 867900005414 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 867900005415 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 867900005416 4Fe-4S binding domain; Region: Fer4_5; pfam12801 867900005417 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 867900005418 FixH; Region: FixH; pfam05751 867900005419 Family description; Region: DsbD_2; pfam13386 867900005420 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 867900005421 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 867900005422 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 867900005423 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 867900005424 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 867900005425 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 867900005426 metal-binding site [ion binding] 867900005427 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 867900005428 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 867900005429 Soluble P-type ATPase [General function prediction only]; Region: COG4087 867900005430 Heavy-metal-associated domain; Region: HMA; pfam00403 867900005431 metal-binding site [ion binding] 867900005432 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 867900005433 active site 867900005434 catalytic site [active] 867900005435 substrate binding site [chemical binding]; other site 867900005436 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 867900005437 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 867900005438 ligand binding site [chemical binding]; other site 867900005439 flexible hinge region; other site 867900005440 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 867900005441 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 867900005442 metal binding triad; other site 867900005443 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 867900005444 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 867900005445 dimer interface [polypeptide binding]; other site 867900005446 active site 867900005447 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 867900005448 catalytic residues [active] 867900005449 substrate binding site [chemical binding]; other site 867900005450 agmatinase; Region: agmatinase; TIGR01230 867900005451 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 867900005452 putative active site [active] 867900005453 Mn binding site [ion binding]; other site 867900005454 deoxyhypusine synthase; Region: dhys; TIGR00321 867900005455 Deoxyhypusine synthase; Region: DS; cl00826 867900005456 Deoxyhypusine synthase; Region: DS; cl00826 867900005457 Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582 867900005458 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 867900005459 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 867900005460 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 867900005461 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 867900005462 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 867900005463 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 867900005464 active site 867900005465 catalytic motif [active] 867900005466 Zn binding site [ion binding]; other site 867900005467 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 867900005468 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 867900005469 tetramer interface [polypeptide binding]; other site 867900005470 TPP-binding site [chemical binding]; other site 867900005471 heterodimer interface [polypeptide binding]; other site 867900005472 phosphorylation loop region [posttranslational modification] 867900005473 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 867900005474 E3 interaction surface; other site 867900005475 lipoyl attachment site [posttranslational modification]; other site 867900005476 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 867900005477 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 867900005478 E3 interaction surface; other site 867900005479 lipoyl attachment site [posttranslational modification]; other site 867900005480 e3 binding domain; Region: E3_binding; pfam02817 867900005481 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 867900005482 M28 Zn-Peptidase IAP aminopeptidase may contain PA domain insert; Region: M28_like_5; cd08021 867900005483 Peptidase family M28; Region: Peptidase_M28; pfam04389 867900005484 metal binding site [ion binding]; metal-binding site 867900005485 short chain dehydrogenase; Provisional; Region: PRK12828 867900005486 classical (c) SDRs; Region: SDR_c; cd05233 867900005487 NAD(P) binding site [chemical binding]; other site 867900005488 active site 867900005489 SprT homologues; Region: SprT; cl01182 867900005490 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 867900005491 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 867900005492 Substrate binding site; other site 867900005493 Major Facilitator Superfamily; Region: MFS_1; pfam07690 867900005494 Domain of unknown function (DUF389); Region: DUF389; pfam04087 867900005495 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 867900005496 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 867900005497 Walker A/P-loop; other site 867900005498 ATP binding site [chemical binding]; other site 867900005499 Q-loop/lid; other site 867900005500 ABC transporter signature motif; other site 867900005501 Walker B; other site 867900005502 D-loop; other site 867900005503 H-loop/switch region; other site 867900005504 Permease; Region: Permease; pfam02405 867900005505 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 867900005506 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 867900005507 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 867900005508 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 867900005509 DXD motif; other site 867900005510 Methyltransferase domain; Region: Methyltransf_23; pfam13489 867900005511 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 867900005512 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 867900005513 dimer interface [polypeptide binding]; other site 867900005514 active site 867900005515 CoA binding pocket [chemical binding]; other site 867900005516 glycine dehydrogenase; Provisional; Region: PRK05367 867900005517 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 867900005518 tetramer interface [polypeptide binding]; other site 867900005519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 867900005520 catalytic residue [active] 867900005521 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 867900005522 tetramer interface [polypeptide binding]; other site 867900005523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 867900005524 catalytic residue [active] 867900005525 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 867900005526 RNA polymerase sigma-70 factor, TIGR02943 family; Region: Sig70_famx1 867900005527 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 867900005528 DNA binding residues [nucleotide binding] 867900005529 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 867900005530 active site residue [active] 867900005531 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 867900005532 TIGR01777 family protein; Region: yfcH 867900005533 NAD(P) binding site [chemical binding]; other site 867900005534 active site 867900005535 Methyltransferase domain; Region: Methyltransf_11; pfam08241 867900005536 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 867900005537 DoxX-like family; Region: DoxX_3; pfam13781 867900005538 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 867900005539 dimerization interface [polypeptide binding]; other site 867900005540 putative Zn2+ binding site [ion binding]; other site 867900005541 putative DNA binding site [nucleotide binding]; other site 867900005542 Resistant to P. syringae 6; Provisional; Region: PLN03210 867900005543 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 867900005544 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cl00653 867900005545 Active_site [active] 867900005546 Leucine rich repeat; Region: LRR_8; pfam13855 867900005547 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 867900005548 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 867900005549 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 867900005550 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 867900005551 active site 867900005552 Zn binding site [ion binding]; other site 867900005553 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 867900005554 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 867900005555 ligand binding site [chemical binding]; other site 867900005556 flexible hinge region; other site 867900005557 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 867900005558 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 867900005559 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 867900005560 Leucine rich repeat; Region: LRR_8; pfam13855 867900005561 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 867900005562 active site 867900005563 AIR carboxylase; Region: AIRC; pfam00731 867900005564 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 867900005565 ATP-grasp domain; Region: ATP-grasp_4; cl17255 867900005566 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 867900005567 active site 867900005568 adenylate kinase; Reviewed; Region: adk; PRK00279 867900005569 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 867900005570 AMP-binding site [chemical binding]; other site 867900005571 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 867900005572 GTPase CgtA; Reviewed; Region: obgE; PRK12299 867900005573 GTP1/OBG; Region: GTP1_OBG; pfam01018 867900005574 Obg GTPase; Region: Obg; cd01898 867900005575 G1 box; other site 867900005576 GTP/Mg2+ binding site [chemical binding]; other site 867900005577 Switch I region; other site 867900005578 G2 box; other site 867900005579 G3 box; other site 867900005580 Switch II region; other site 867900005581 G4 box; other site 867900005582 G5 box; other site 867900005583 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 867900005584 Histidine kinase; Region: His_kinase; pfam06580 867900005585 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 867900005586 Mg2+ binding site [ion binding]; other site 867900005587 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 867900005588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900005589 active site 867900005590 phosphorylation site [posttranslational modification] 867900005591 intermolecular recognition site; other site 867900005592 dimerization interface [polypeptide binding]; other site 867900005593 LytTr DNA-binding domain; Region: LytTR; smart00850 867900005594 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 867900005595 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 867900005596 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 867900005597 putative active site [active] 867900005598 catalytic site [active] 867900005599 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 867900005600 putative active site [active] 867900005601 catalytic site [active] 867900005602 MG2 domain; Region: A2M_N; pfam01835 867900005603 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 867900005604 Alpha-2-macroglobulin family; Region: A2M; pfam00207 867900005605 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 867900005606 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 867900005607 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 867900005608 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 867900005609 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 867900005610 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 867900005611 nucleotide binding site [chemical binding]; other site 867900005612 putative NEF/HSP70 interaction site [polypeptide binding]; other site 867900005613 SBD interface [polypeptide binding]; other site 867900005614 hypothetical protein; Reviewed; Region: PRK00024 867900005615 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 867900005616 MPN+ (JAMM) motif; other site 867900005617 Zinc-binding site [ion binding]; other site 867900005618 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931 867900005619 putative active site [active] 867900005620 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 867900005621 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 867900005622 motif II; other site 867900005623 Uncharacterized protein conserved in Bacteroidetes; Region: DUF4425; cl16901 867900005624 recombination factor protein RarA; Reviewed; Region: PRK13342 867900005625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 867900005626 Walker A motif; other site 867900005627 ATP binding site [chemical binding]; other site 867900005628 Walker B motif; other site 867900005629 arginine finger; other site 867900005630 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 867900005631 Rhomboid family; Region: Rhomboid; pfam01694 867900005632 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 867900005633 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 867900005634 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 867900005635 starch binding outer membrane protein SusD; Region: SusD; cl17845 867900005636 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 867900005637 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900005638 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 867900005639 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900005640 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 867900005641 starch binding outer membrane protein SusD; Region: SusD; cd08977 867900005642 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 867900005643 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900005644 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 867900005645 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900005646 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 867900005647 starch binding outer membrane protein SusD; Region: SusD; cl17845 867900005648 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 867900005649 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900005650 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 867900005651 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900005652 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 867900005653 S17 interaction site [polypeptide binding]; other site 867900005654 S8 interaction site; other site 867900005655 16S rRNA interaction site [nucleotide binding]; other site 867900005656 streptomycin interaction site [chemical binding]; other site 867900005657 23S rRNA interaction site [nucleotide binding]; other site 867900005658 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 867900005659 30S ribosomal protein S7; Validated; Region: PRK05302 867900005660 elongation factor G; Reviewed; Region: PRK12739 867900005661 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 867900005662 G1 box; other site 867900005663 putative GEF interaction site [polypeptide binding]; other site 867900005664 GTP/Mg2+ binding site [chemical binding]; other site 867900005665 Switch I region; other site 867900005666 G2 box; other site 867900005667 G3 box; other site 867900005668 Switch II region; other site 867900005669 G4 box; other site 867900005670 G5 box; other site 867900005671 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 867900005672 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 867900005673 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 867900005674 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 867900005675 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 867900005676 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 867900005677 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 867900005678 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 867900005679 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 867900005680 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 867900005681 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 867900005682 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 867900005683 protein-rRNA interface [nucleotide binding]; other site 867900005684 putative translocon binding site; other site 867900005685 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 867900005686 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 867900005687 G-X-X-G motif; other site 867900005688 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 867900005689 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 867900005690 23S rRNA interface [nucleotide binding]; other site 867900005691 5S rRNA interface [nucleotide binding]; other site 867900005692 putative antibiotic binding site [chemical binding]; other site 867900005693 L25 interface [polypeptide binding]; other site 867900005694 L27 interface [polypeptide binding]; other site 867900005695 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 867900005696 23S rRNA interface [nucleotide binding]; other site 867900005697 putative translocon interaction site; other site 867900005698 signal recognition particle (SRP54) interaction site; other site 867900005699 L23 interface [polypeptide binding]; other site 867900005700 trigger factor interaction site; other site 867900005701 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 867900005702 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 867900005703 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 867900005704 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 867900005705 RNA binding site [nucleotide binding]; other site 867900005706 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 867900005707 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 867900005708 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 867900005709 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 867900005710 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 867900005711 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 867900005712 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 867900005713 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 867900005714 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 867900005715 5S rRNA interface [nucleotide binding]; other site 867900005716 L27 interface [polypeptide binding]; other site 867900005717 23S rRNA interface [nucleotide binding]; other site 867900005718 L5 interface [polypeptide binding]; other site 867900005719 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 867900005720 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 867900005721 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 867900005722 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 867900005723 23S rRNA binding site [nucleotide binding]; other site 867900005724 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 867900005725 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 867900005726 SecY translocase; Region: SecY; pfam00344 867900005727 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 867900005728 rRNA binding site [nucleotide binding]; other site 867900005729 predicted 30S ribosome binding site; other site 867900005730 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 867900005731 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 867900005732 30S ribosomal protein S13; Region: bact_S13; TIGR03631 867900005733 30S ribosomal protein S11; Validated; Region: PRK05309 867900005734 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 867900005735 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 867900005736 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 867900005737 RNA binding surface [nucleotide binding]; other site 867900005738 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 867900005739 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 867900005740 alphaNTD homodimer interface [polypeptide binding]; other site 867900005741 alphaNTD - beta interaction site [polypeptide binding]; other site 867900005742 alphaNTD - beta' interaction site [polypeptide binding]; other site 867900005743 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 867900005744 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 867900005745 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 867900005746 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 867900005747 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 867900005748 catalytic site [active] 867900005749 subunit interface [polypeptide binding]; other site 867900005750 enolase; Provisional; Region: eno; PRK00077 867900005751 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 867900005752 dimer interface [polypeptide binding]; other site 867900005753 metal binding site [ion binding]; metal-binding site 867900005754 substrate binding pocket [chemical binding]; other site 867900005755 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 867900005756 dimer interface [polypeptide binding]; other site 867900005757 Citrate synthase; Region: Citrate_synt; pfam00285 867900005758 active site 867900005759 citrylCoA binding site [chemical binding]; other site 867900005760 NADH binding [chemical binding]; other site 867900005761 cationic pore residues; other site 867900005762 oxalacetate/citrate binding site [chemical binding]; other site 867900005763 coenzyme A binding site [chemical binding]; other site 867900005764 catalytic triad [active] 867900005765 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 867900005766 Amidinotransferase; Region: Amidinotransf; cl12043 867900005767 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 867900005768 Amidinotransferase; Region: Amidinotransf; pfam02274 867900005769 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 867900005770 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 867900005771 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 867900005772 active site 867900005773 HIGH motif; other site 867900005774 nucleotide binding site [chemical binding]; other site 867900005775 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 867900005776 KMSK motif region; other site 867900005777 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 867900005778 tRNA binding surface [nucleotide binding]; other site 867900005779 anticodon binding site; other site 867900005780 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 867900005781 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900005782 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900005783 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 867900005784 FecR protein; Region: FecR; pfam04773 867900005785 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 867900005786 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 867900005787 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 867900005788 DNA binding residues [nucleotide binding] 867900005789 signal recognition particle protein; Provisional; Region: PRK10867 867900005790 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 867900005791 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 867900005792 P loop; other site 867900005793 GTP binding site [chemical binding]; other site 867900005794 Signal peptide binding domain; Region: SRP_SPB; pfam02978 867900005795 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185 867900005796 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 867900005797 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 867900005798 homodimer interface [polypeptide binding]; other site 867900005799 NADP binding site [chemical binding]; other site 867900005800 substrate binding site [chemical binding]; other site 867900005801 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 867900005802 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 867900005803 active site residue [active] 867900005804 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 867900005805 active site residue [active] 867900005806 Predicted transcriptional regulator [Transcription]; Region: COG2378 867900005807 HTH domain; Region: HTH_11; pfam08279 867900005808 WYL domain; Region: WYL; pfam13280 867900005809 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 867900005810 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 867900005811 Putative esterase; Region: Esterase; pfam00756 867900005812 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 867900005813 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 867900005814 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 867900005815 Zonular occludens toxin (Zot); Region: Zot; cl17485 867900005816 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 867900005817 Cupin domain; Region: Cupin_2; pfam07883 867900005818 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 867900005819 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 867900005820 nucleophilic elbow; other site 867900005821 catalytic triad; other site 867900005822 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 867900005823 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 867900005824 putative metal binding site [ion binding]; other site 867900005825 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 867900005826 S-adenosylmethionine binding site [chemical binding]; other site 867900005827 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 867900005828 Flagellin N-methylase; Region: FliB; pfam03692 867900005829 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 867900005830 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 867900005831 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 867900005832 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 867900005833 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 867900005834 FtsX-like permease family; Region: FtsX; pfam02687 867900005835 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 867900005836 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 867900005837 dimer interface [polypeptide binding]; other site 867900005838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 867900005839 catalytic residue [active] 867900005840 maltose O-acetyltransferase; Provisional; Region: PRK10092 867900005841 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 867900005842 active site 867900005843 substrate binding site [chemical binding]; other site 867900005844 trimer interface [polypeptide binding]; other site 867900005845 CoA binding site [chemical binding]; other site 867900005846 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 867900005847 active site 867900005848 catalytic residues [active] 867900005849 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 867900005850 high affinity sulphate transporter 1; Region: sulP; TIGR00815 867900005851 Sulfate transporter family; Region: Sulfate_transp; pfam00916 867900005852 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 867900005853 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 867900005854 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 867900005855 active site residue [active] 867900005856 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 867900005857 active site residue [active] 867900005858 L-fucose transporter; Provisional; Region: PRK10133; cl17665 867900005859 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 867900005860 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 867900005861 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 867900005862 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 867900005863 FeS/SAM binding site; other site 867900005864 HemN C-terminal domain; Region: HemN_C; pfam06969 867900005865 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 867900005866 Ligand Binding Site [chemical binding]; other site 867900005867 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 867900005868 Ligand Binding Site [chemical binding]; other site 867900005869 YtxH-like protein; Region: YtxH; pfam12732 867900005870 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 867900005871 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 867900005872 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 867900005873 ligand binding site [chemical binding]; other site 867900005874 flexible hinge region; other site 867900005875 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 867900005876 homotrimer interaction site [polypeptide binding]; other site 867900005877 putative active site [active] 867900005878 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 867900005879 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 867900005880 ligand binding site [chemical binding]; other site 867900005881 MerC mercury resistance protein; Region: MerC; pfam03203 867900005882 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 867900005883 GTP cyclohydrolase I; Provisional; Region: PLN03044 867900005884 active site 867900005885 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 867900005886 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 867900005887 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900005888 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 867900005889 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 867900005890 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 867900005891 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 867900005892 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 867900005893 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 867900005894 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 867900005895 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 867900005896 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 867900005897 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 867900005898 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 867900005899 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 867900005900 Flavodoxin; Region: Flavodoxin_1; pfam00258 867900005901 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 867900005902 FAD binding pocket [chemical binding]; other site 867900005903 conserved FAD binding motif [chemical binding]; other site 867900005904 phosphate binding motif [ion binding]; other site 867900005905 beta-alpha-beta structure motif; other site 867900005906 NAD binding pocket [chemical binding]; other site 867900005907 DNA Topoisomerase IV; Region: TOP4c; smart00434 867900005908 Protein kinase domain; Region: Pkinase; pfam00069 867900005909 Catalytic domain of Protein Kinases; Region: PKc; cd00180 867900005910 active site 867900005911 ATP binding site [chemical binding]; other site 867900005912 substrate binding site [chemical binding]; other site 867900005913 activation loop (A-loop); other site 867900005914 AAA domain; Region: AAA_11; pfam13086 867900005915 Part of AAA domain; Region: AAA_19; pfam13245 867900005916 AAA domain; Region: AAA_12; pfam13087 867900005917 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 867900005918 putative active site [active] 867900005919 catalytic site [active] 867900005920 RDD family; Region: RDD; pfam06271 867900005921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 867900005922 Nucleoporin protein Ndc1-Nup; Region: Ndc1_Nup; pfam09531 867900005923 LytTr DNA-binding domain; Region: LytTR; smart00850 867900005924 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 867900005925 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 867900005926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 867900005927 Saccharopine Dehydrogenase like proteins; Region: SDH_like; cd05199 867900005928 active site 867900005929 ligand binding site [chemical binding]; other site 867900005930 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; pfam01262 867900005931 NAD(P) binding site [chemical binding]; other site 867900005932 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 867900005933 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 867900005934 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 867900005935 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 867900005936 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 867900005937 catalytic residues [active] 867900005938 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 867900005939 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 867900005940 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 867900005941 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 867900005942 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 867900005943 G1 box; other site 867900005944 putative GEF interaction site [polypeptide binding]; other site 867900005945 GTP/Mg2+ binding site [chemical binding]; other site 867900005946 Switch I region; other site 867900005947 G2 box; other site 867900005948 G3 box; other site 867900005949 Switch II region; other site 867900005950 G4 box; other site 867900005951 G5 box; other site 867900005952 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 867900005953 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 867900005954 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 867900005955 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 867900005956 nucleotide binding site [chemical binding]; other site 867900005957 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 867900005958 active site 867900005959 catalytic residues [active] 867900005960 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 867900005961 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 867900005962 TrkA-C domain; Region: TrkA_C; pfam02080 867900005963 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 867900005964 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 867900005965 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 867900005966 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 867900005967 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 867900005968 Cation efflux family; Region: Cation_efflux; pfam01545 867900005969 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 867900005970 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 867900005971 Walker A/P-loop; other site 867900005972 ATP binding site [chemical binding]; other site 867900005973 Q-loop/lid; other site 867900005974 ABC transporter signature motif; other site 867900005975 Walker B; other site 867900005976 D-loop; other site 867900005977 H-loop/switch region; other site 867900005978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900005979 binding surface 867900005980 TPR motif; other site 867900005981 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900005982 TPR motif; other site 867900005983 binding surface 867900005984 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 867900005985 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 867900005986 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 867900005987 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900005988 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 867900005989 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 867900005990 active site 867900005991 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 867900005992 asparagine synthetase B; Provisional; Region: asnB; PRK09431 867900005993 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 867900005994 active site 867900005995 dimer interface [polypeptide binding]; other site 867900005996 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 867900005997 Ligand Binding Site [chemical binding]; other site 867900005998 Molecular Tunnel; other site 867900005999 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 867900006000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900006001 ATP binding site [chemical binding]; other site 867900006002 Mg2+ binding site [ion binding]; other site 867900006003 G-X-G motif; other site 867900006004 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 867900006005 anchoring element; other site 867900006006 dimer interface [polypeptide binding]; other site 867900006007 ATP binding site [chemical binding]; other site 867900006008 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 867900006009 active site 867900006010 putative metal-binding site [ion binding]; other site 867900006011 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 867900006012 malate dehydrogenase; Reviewed; Region: PRK06223 867900006013 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 867900006014 dimer interface [polypeptide binding]; other site 867900006015 NAD(P) binding site [chemical binding]; other site 867900006016 tetramer (dimer of dimers) interface [polypeptide binding]; other site 867900006017 substrate binding site [chemical binding]; other site 867900006018 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 867900006019 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 867900006020 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 867900006021 Protein export membrane protein; Region: SecD_SecF; cl14618 867900006022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 867900006023 ABC transporter signature motif; other site 867900006024 Walker B; other site 867900006025 D-loop; other site 867900006026 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 867900006027 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 867900006028 Walker A/P-loop; other site 867900006029 ATP binding site [chemical binding]; other site 867900006030 Q-loop/lid; other site 867900006031 ABC transporter signature motif; other site 867900006032 Walker B; other site 867900006033 D-loop; other site 867900006034 H-loop/switch region; other site 867900006035 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 867900006036 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 867900006037 Coenzyme A binding pocket [chemical binding]; other site 867900006038 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 867900006039 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 867900006040 Haemolytic domain; Region: Haemolytic; pfam01809 867900006041 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 867900006042 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 867900006043 active site 867900006044 HIGH motif; other site 867900006045 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 867900006046 KMSKS motif; other site 867900006047 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 867900006048 anticodon binding site; other site 867900006049 tRNA binding surface [nucleotide binding]; other site 867900006050 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 867900006051 GTP cyclohydrolase I; Provisional; Region: PLN03044 867900006052 active site 867900006053 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 867900006054 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 867900006055 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 867900006056 prolyl-tRNA synthetase; Provisional; Region: PRK08661 867900006057 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 867900006058 dimer interface [polypeptide binding]; other site 867900006059 motif 1; other site 867900006060 active site 867900006061 motif 2; other site 867900006062 motif 3; other site 867900006063 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 867900006064 anticodon binding site; other site 867900006065 zinc-binding site [ion binding]; other site 867900006066 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 867900006067 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 867900006068 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 867900006069 transcription termination factor Rho; Provisional; Region: PRK12608 867900006070 RNA binding site [nucleotide binding]; other site 867900006071 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 867900006072 multimer interface [polypeptide binding]; other site 867900006073 Walker A motif; other site 867900006074 ATP binding site [chemical binding]; other site 867900006075 Walker B motif; other site 867900006076 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 867900006077 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 867900006078 Helix-turn-helix domain; Region: HTH_18; pfam12833 867900006079 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 867900006080 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 867900006081 active site 867900006082 metal binding site [ion binding]; metal-binding site 867900006083 homotetramer interface [polypeptide binding]; other site 867900006084 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 867900006085 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 867900006086 dimerization interface 3.5A [polypeptide binding]; other site 867900006087 active site 867900006088 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 867900006089 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 867900006090 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 867900006091 Walker A/P-loop; other site 867900006092 ATP binding site [chemical binding]; other site 867900006093 Q-loop/lid; other site 867900006094 ABC transporter signature motif; other site 867900006095 Walker B; other site 867900006096 D-loop; other site 867900006097 H-loop/switch region; other site 867900006098 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 867900006099 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 867900006100 TIGR00159 family protein; Region: TIGR00159 867900006101 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 867900006102 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 867900006103 dihydropteroate synthase; Region: DHPS; TIGR01496 867900006104 substrate binding pocket [chemical binding]; other site 867900006105 dimer interface [polypeptide binding]; other site 867900006106 inhibitor binding site; inhibition site 867900006107 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 867900006108 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 867900006109 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 867900006110 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 867900006111 triosephosphate isomerase; Provisional; Region: PRK14567 867900006112 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 867900006113 substrate binding site [chemical binding]; other site 867900006114 dimer interface [polypeptide binding]; other site 867900006115 catalytic triad [active] 867900006116 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 867900006117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 867900006118 S-adenosylmethionine binding site [chemical binding]; other site 867900006119 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 867900006120 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 867900006121 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 867900006122 Fn3 associated; Region: Fn3_assoc; pfam13287 867900006123 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 867900006124 Sulfatase; Region: Sulfatase; cl17466 867900006125 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 867900006126 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 867900006127 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 867900006128 two-component response regulator; Provisional; Region: PRK14084 867900006129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900006130 active site 867900006131 phosphorylation site [posttranslational modification] 867900006132 intermolecular recognition site; other site 867900006133 dimerization interface [polypeptide binding]; other site 867900006134 LytTr DNA-binding domain; Region: LytTR; smart00850 867900006135 Histidine kinase; Region: His_kinase; pfam06580 867900006136 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 867900006137 putative ligand binding site [chemical binding]; other site 867900006138 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 867900006139 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 867900006140 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 867900006141 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 867900006142 active site 867900006143 Fn3 associated; Region: Fn3_assoc; pfam13287 867900006144 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 867900006145 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 867900006146 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 867900006147 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 867900006148 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900006149 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 867900006150 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900006151 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 867900006152 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 867900006153 starch binding outer membrane protein SusD; Region: SusD; cl17845 867900006154 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 867900006155 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 867900006156 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 867900006157 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 867900006158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900006159 active site 867900006160 phosphorylation site [posttranslational modification] 867900006161 intermolecular recognition site; other site 867900006162 dimerization interface [polypeptide binding]; other site 867900006163 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 867900006164 DNA binding site [nucleotide binding] 867900006165 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 867900006166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 867900006167 dimer interface [polypeptide binding]; other site 867900006168 phosphorylation site [posttranslational modification] 867900006169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900006170 ATP binding site [chemical binding]; other site 867900006171 Mg2+ binding site [ion binding]; other site 867900006172 G-X-G motif; other site 867900006173 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 867900006174 putative ligand binding site [chemical binding]; other site 867900006175 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 867900006176 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 867900006177 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 867900006178 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 867900006179 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 867900006180 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 867900006181 HlyD family secretion protein; Region: HlyD_3; pfam13437 867900006182 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 867900006183 starch binding outer membrane protein SusD; Region: SusD; cd08977 867900006184 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 867900006185 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900006186 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 867900006187 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900006188 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 867900006189 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 867900006190 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 867900006191 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 867900006192 dimer interface [polypeptide binding]; other site 867900006193 phosphorylation site [posttranslational modification] 867900006194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900006195 ATP binding site [chemical binding]; other site 867900006196 Mg2+ binding site [ion binding]; other site 867900006197 G-X-G motif; other site 867900006198 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 867900006199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900006200 active site 867900006201 phosphorylation site [posttranslational modification] 867900006202 intermolecular recognition site; other site 867900006203 dimerization interface [polypeptide binding]; other site 867900006204 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 867900006205 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 867900006206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 867900006207 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 867900006208 NAD(P) binding site [chemical binding]; other site 867900006209 active site 867900006210 Transcriptional regulators [Transcription]; Region: PurR; COG1609 867900006211 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 867900006212 DNA binding site [nucleotide binding] 867900006213 domain linker motif; other site 867900006214 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 867900006215 dimerization interface [polypeptide binding]; other site 867900006216 ligand binding site [chemical binding]; other site 867900006217 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 867900006218 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 867900006219 NAD binding site [chemical binding]; other site 867900006220 homodimer interface [polypeptide binding]; other site 867900006221 active site 867900006222 substrate binding site [chemical binding]; other site 867900006223 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 867900006224 DNA-binding site [nucleotide binding]; DNA binding site 867900006225 Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276 867900006226 putative dimerization interface [polypeptide binding]; other site 867900006227 putative ligand binding site [chemical binding]; other site 867900006228 Transcriptional regulators [Transcription]; Region: PurR; COG1609 867900006229 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 867900006230 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 867900006231 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 867900006232 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 867900006233 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 867900006234 dimer interface [polypeptide binding]; other site 867900006235 active site 867900006236 Chloramphenicol acetyltransferase; Region: CAT; smart01059 867900006237 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 867900006238 Transcriptional regulators [Transcription]; Region: PurR; COG1609 867900006239 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 867900006240 DNA binding site [nucleotide binding] 867900006241 domain linker motif; other site 867900006242 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 867900006243 dimerization interface [polypeptide binding]; other site 867900006244 ligand binding site [chemical binding]; other site 867900006245 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 867900006246 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 867900006247 substrate binding site [chemical binding]; other site 867900006248 ATP binding site [chemical binding]; other site 867900006249 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 867900006250 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 867900006251 active site 867900006252 intersubunit interface [polypeptide binding]; other site 867900006253 catalytic residue [active] 867900006254 AAA domain; Region: AAA_30; pfam13604 867900006255 Family description; Region: UvrD_C_2; pfam13538 867900006256 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 867900006257 catalytic motif [active] 867900006258 Catalytic residue [active] 867900006259 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 867900006260 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 867900006261 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 867900006262 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 867900006263 Radical SAM superfamily; Region: Radical_SAM; pfam04055 867900006264 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 867900006265 non-specific DNA binding site [nucleotide binding]; other site 867900006266 salt bridge; other site 867900006267 sequence-specific DNA binding site [nucleotide binding]; other site 867900006268 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 867900006269 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 867900006270 ATP binding site [chemical binding]; other site 867900006271 putative Mg++ binding site [ion binding]; other site 867900006272 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 867900006273 nucleotide binding region [chemical binding]; other site 867900006274 ATP-binding site [chemical binding]; other site 867900006275 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 867900006276 Divergent AAA domain; Region: AAA_4; pfam04326 867900006277 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 867900006278 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 867900006279 putative DNA binding site [nucleotide binding]; other site 867900006280 putative Zn2+ binding site [ion binding]; other site 867900006281 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 867900006282 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 867900006283 ATP binding site [chemical binding]; other site 867900006284 putative Mg++ binding site [ion binding]; other site 867900006285 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 867900006286 ATP-binding site [chemical binding]; other site 867900006287 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 867900006288 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 867900006289 Part of AAA domain; Region: AAA_19; pfam13245 867900006290 hypothetical protein; Validated; Region: PRK08116 867900006291 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 867900006292 Walker A motif; other site 867900006293 ATP binding site [chemical binding]; other site 867900006294 Helix-turn-helix domain; Region: HTH_17; pfam12728 867900006295 RteC protein; Region: RteC; pfam09357 867900006296 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 867900006297 active site 867900006298 DNA binding site [nucleotide binding] 867900006299 Int/Topo IB signature motif; other site 867900006300 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 867900006301 active site 867900006302 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 867900006303 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 867900006304 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 867900006305 glutamine synthetase; Region: PLN02284 867900006306 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 867900006307 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 867900006308 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 867900006309 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 867900006310 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 867900006311 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 867900006312 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 867900006313 replicative DNA helicase; Region: DnaB; TIGR00665 867900006314 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 867900006315 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 867900006316 Walker A motif; other site 867900006317 ATP binding site [chemical binding]; other site 867900006318 Walker B motif; other site 867900006319 DNA binding loops [nucleotide binding] 867900006320 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 867900006321 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 867900006322 active site 867900006323 motif I; other site 867900006324 motif II; other site 867900006325 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 867900006326 Tic20-like protein; Region: Tic20; pfam09685 867900006327 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 867900006328 23S rRNA binding site [nucleotide binding]; other site 867900006329 L21 binding site [polypeptide binding]; other site 867900006330 L13 binding site [polypeptide binding]; other site 867900006331 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 867900006332 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 867900006333 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 867900006334 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 867900006335 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 867900006336 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 867900006337 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 867900006338 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 867900006339 active site 867900006340 dimer interface [polypeptide binding]; other site 867900006341 motif 1; other site 867900006342 motif 2; other site 867900006343 motif 3; other site 867900006344 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 867900006345 anticodon binding site; other site 867900006346 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 867900006347 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 867900006348 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 867900006349 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 867900006350 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 867900006351 homoserine kinase; Provisional; Region: PRK01212 867900006352 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 867900006353 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 867900006354 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 867900006355 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 867900006356 putative catalytic residues [active] 867900006357 putative nucleotide binding site [chemical binding]; other site 867900006358 putative aspartate binding site [chemical binding]; other site 867900006359 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 867900006360 dimer interface [polypeptide binding]; other site 867900006361 putative threonine allosteric regulatory site; other site 867900006362 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 867900006363 putative threonine allosteric regulatory site; other site 867900006364 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 867900006365 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 867900006366 putative carbohydrate kinase; Provisional; Region: PRK10565 867900006367 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 867900006368 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 867900006369 putative substrate binding site [chemical binding]; other site 867900006370 putative ATP binding site [chemical binding]; other site 867900006371 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 867900006372 Clp amino terminal domain; Region: Clp_N; pfam02861 867900006373 Clp amino terminal domain; Region: Clp_N; pfam02861 867900006374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 867900006375 Walker A motif; other site 867900006376 ATP binding site [chemical binding]; other site 867900006377 Walker B motif; other site 867900006378 arginine finger; other site 867900006379 UvrB/uvrC motif; Region: UVR; pfam02151 867900006380 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 867900006381 Walker A motif; other site 867900006382 ATP binding site [chemical binding]; other site 867900006383 Walker B motif; other site 867900006384 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 867900006385 DNA gyrase subunit A; Validated; Region: PRK05560 867900006386 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 867900006387 CAP-like domain; other site 867900006388 active site 867900006389 primary dimer interface [polypeptide binding]; other site 867900006390 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 867900006391 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 867900006392 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 867900006393 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 867900006394 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 867900006395 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 867900006396 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900006397 binding surface 867900006398 TPR motif; other site 867900006399 Tetratricopeptide repeat; Region: TPR_16; pfam13432 867900006400 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 867900006401 NlpC/P60 family; Region: NLPC_P60; cl17555 867900006402 acetyl-CoA C-acetyltransferase; Region: PLN02644 867900006403 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 867900006404 dimer interface [polypeptide binding]; other site 867900006405 active site 867900006406 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 867900006407 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 867900006408 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 867900006409 Zn2+ binding site [ion binding]; other site 867900006410 Mg2+ binding site [ion binding]; other site 867900006411 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 867900006412 carboxyltransferase (CT) interaction site; other site 867900006413 biotinylation site [posttranslational modification]; other site 867900006414 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 867900006415 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 867900006416 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 867900006417 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 867900006418 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 867900006419 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 867900006420 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 867900006421 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 867900006422 trehalose synthase; Region: treS_nterm; TIGR02456 867900006423 active site 867900006424 catalytic site [active] 867900006425 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 867900006426 Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087 867900006427 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340 867900006428 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 867900006429 Ca binding site [ion binding]; other site 867900006430 active site 867900006431 homodimer interface [polypeptide binding]; other site 867900006432 catalytic site [active] 867900006433 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 867900006434 maltose phosphorylase; Provisional; Region: PRK13807 867900006435 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 867900006436 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 867900006437 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 867900006438 beta-phosphoglucomutase; Region: bPGM; TIGR01990 867900006439 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 867900006440 motif II; other site 867900006441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 867900006442 Major Facilitator Superfamily; Region: MFS_1; pfam07690 867900006443 putative substrate translocation pore; other site 867900006444 Transcriptional regulators [Transcription]; Region: PurR; COG1609 867900006445 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 867900006446 DNA binding site [nucleotide binding] 867900006447 domain linker motif; other site 867900006448 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 867900006449 dimerization interface [polypeptide binding]; other site 867900006450 ligand binding site [chemical binding]; other site 867900006451 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 867900006452 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900006453 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 867900006454 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900006455 starch binding outer membrane protein SusD; Region: SusD; cd08977 867900006456 SusE outer membrane protein; Region: SusE; pfam14292 867900006457 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cd12956 867900006458 starch binding site [chemical binding]; other site 867900006459 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cd12956 867900006460 starch binding site [chemical binding]; other site 867900006461 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cd12956 867900006462 starch binding site [chemical binding]; other site 867900006463 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 867900006464 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 867900006465 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 867900006466 active site 867900006467 catalytic site [active] 867900006468 TPR repeat; Region: TPR_11; pfam13414 867900006469 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900006470 TPR motif; other site 867900006471 binding surface 867900006472 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 867900006473 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 867900006474 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 867900006475 ligand binding site [chemical binding]; other site 867900006476 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 867900006477 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 867900006478 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 867900006479 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 867900006480 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 867900006481 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 867900006482 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 867900006483 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 867900006484 catalytic residue [active] 867900006485 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 867900006486 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 867900006487 active site 867900006488 catalytic site [active] 867900006489 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 867900006490 active site 867900006491 catalytic residues [active] 867900006492 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 867900006493 starch binding outer membrane protein SusD; Region: SusD; cl17845 867900006494 SusD family; Region: SusD; pfam07980 867900006495 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 867900006496 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900006497 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 867900006498 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 867900006499 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 867900006500 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 867900006501 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 867900006502 dimerization interface [polypeptide binding]; other site 867900006503 DNA binding residues [nucleotide binding] 867900006504 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 867900006505 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 867900006506 Helix-turn-helix domain; Region: HTH_18; pfam12833 867900006507 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 867900006508 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 867900006509 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900006510 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900006511 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 867900006512 starch binding outer membrane protein SusD; Region: SusD; cd08977 867900006513 SusD family; Region: SusD; pfam07980 867900006514 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577 867900006515 putative active site [active] 867900006516 catalytic site [active] 867900006517 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 867900006518 Alkaline phosphatase homologues; Region: alkPPc; smart00098 867900006519 active site 867900006520 dimer interface [polypeptide binding]; other site 867900006521 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 867900006522 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 867900006523 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 867900006524 DNA binding residues [nucleotide binding] 867900006525 FecR protein; Region: FecR; pfam04773 867900006526 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 867900006527 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 867900006528 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900006529 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 867900006530 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 867900006531 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900006532 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 867900006533 starch binding outer membrane protein SusD; Region: SusD; cl17845 867900006534 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 867900006535 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 867900006536 catalytic residues [active] 867900006537 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 867900006538 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 867900006539 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 867900006540 catalytic residues [active] 867900006541 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 867900006542 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 867900006543 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 867900006544 catalytic residues [active] 867900006545 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 867900006546 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 867900006547 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 867900006548 catalytic residues [active] 867900006549 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 867900006550 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 867900006551 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 867900006552 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 867900006553 catalytic residues [active] 867900006554 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 867900006555 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 867900006556 starch binding outer membrane protein SusD; Region: SusD; cl17845 867900006557 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 867900006558 SusD family; Region: SusD; pfam07980 867900006559 Secretin and TonB N terminus short domain; Region: STN; pfam07660 867900006560 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 867900006561 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900006562 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 867900006563 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900006564 FecR protein; Region: FecR; pfam04773 867900006565 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 867900006566 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 867900006567 DNA binding residues [nucleotide binding] 867900006568 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 867900006569 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 867900006570 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 867900006571 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 867900006572 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 867900006573 dimer interface [polypeptide binding]; other site 867900006574 phosphorylation site [posttranslational modification] 867900006575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900006576 ATP binding site [chemical binding]; other site 867900006577 Mg2+ binding site [ion binding]; other site 867900006578 G-X-G motif; other site 867900006579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900006580 active site 867900006581 phosphorylation site [posttranslational modification] 867900006582 intermolecular recognition site; other site 867900006583 dimerization interface [polypeptide binding]; other site 867900006584 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 867900006585 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 867900006586 GH3 auxin-responsive promoter; Region: GH3; pfam03321 867900006587 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 867900006588 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 867900006589 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 867900006590 putative active site [active] 867900006591 catalytic site [active] 867900006592 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 867900006593 putative active site [active] 867900006594 catalytic site [active] 867900006595 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 867900006596 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 867900006597 dimerization interface [polypeptide binding]; other site 867900006598 DPS ferroxidase diiron center [ion binding]; other site 867900006599 ion pore; other site 867900006600 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 867900006601 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 867900006602 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 867900006603 CHASE3 domain; Region: CHASE3; pfam05227 867900006604 PAS domain; Region: PAS_9; pfam13426 867900006605 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 867900006606 PAS fold; Region: PAS_3; pfam08447 867900006607 putative active site [active] 867900006608 heme pocket [chemical binding]; other site 867900006609 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 867900006610 dimer interface [polypeptide binding]; other site 867900006611 phosphorylation site [posttranslational modification] 867900006612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900006613 ATP binding site [chemical binding]; other site 867900006614 Mg2+ binding site [ion binding]; other site 867900006615 G-X-G motif; other site 867900006616 Response regulator receiver domain; Region: Response_reg; pfam00072 867900006617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900006618 active site 867900006619 phosphorylation site [posttranslational modification] 867900006620 intermolecular recognition site; other site 867900006621 dimerization interface [polypeptide binding]; other site 867900006622 Helix-turn-helix domain; Region: HTH_18; pfam12833 867900006623 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 867900006624 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 867900006625 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 867900006626 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 867900006627 NAD(P) binding site [chemical binding]; other site 867900006628 catalytic residues [active] 867900006629 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 867900006630 30S subunit binding site; other site 867900006631 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 867900006632 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 867900006633 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 867900006634 Domain of unknown function DUF20; Region: UPF0118; pfam01594 867900006635 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 867900006636 Cupin domain; Region: Cupin_2; pfam07883 867900006637 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 867900006638 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 867900006639 Cytochrome P450; Region: p450; cl12078 867900006640 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 867900006641 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 867900006642 catalytic loop [active] 867900006643 iron binding site [ion binding]; other site 867900006644 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 867900006645 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 867900006646 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 867900006647 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 867900006648 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 867900006649 starch binding outer membrane protein SusD; Region: SusD; cl17845 867900006650 SusD family; Region: SusD; pfam07980 867900006651 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900006652 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 867900006653 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 867900006654 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900006655 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900006656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 867900006657 Major Facilitator Superfamily; Region: MFS_1; pfam07690 867900006658 putative substrate translocation pore; other site 867900006659 Uncharacterized conserved protein [Function unknown]; Region: COG1262 867900006660 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 867900006661 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 867900006662 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 867900006663 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 867900006664 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 867900006665 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900006666 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 867900006667 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900006668 starch binding outer membrane protein SusD; Region: SusD; cd08977 867900006669 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 867900006670 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 867900006671 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 867900006672 catalytic residue [active] 867900006673 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 867900006674 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 867900006675 active site 867900006676 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 867900006677 PspC domain; Region: PspC; pfam04024 867900006678 Domain of unknown function (DUF4203); Region: DUF4203; pfam13886 867900006679 Predicted transcriptional regulators [Transcription]; Region: COG1695 867900006680 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 867900006681 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 867900006682 active site 2 [active] 867900006683 active site 1 [active] 867900006684 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 867900006685 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 867900006686 Transcriptional regulator [Transcription]; Region: LysR; COG0583 867900006687 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 867900006688 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 867900006689 dimerization interface [polypeptide binding]; other site 867900006690 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 867900006691 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 867900006692 dimerization interface [polypeptide binding]; other site 867900006693 DPS ferroxidase diiron center [ion binding]; other site 867900006694 ion pore; other site 867900006695 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 867900006696 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 867900006697 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 867900006698 putative catalytic site [active] 867900006699 putative metal binding site [ion binding]; other site 867900006700 putative phosphate binding site [ion binding]; other site 867900006701 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 867900006702 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 867900006703 RNA binding surface [nucleotide binding]; other site 867900006704 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 867900006705 probable active site [active] 867900006706 Histidine kinase; Region: His_kinase; pfam06580 867900006707 2TM domain; Region: 2TM; pfam13239 867900006708 2TM domain; Region: 2TM; pfam13239 867900006709 2TM domain; Region: 2TM; pfam13239 867900006710 2TM domain; Region: 2TM; pfam13239 867900006711 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 867900006712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900006713 active site 867900006714 phosphorylation site [posttranslational modification] 867900006715 intermolecular recognition site; other site 867900006716 dimerization interface [polypeptide binding]; other site 867900006717 LytTr DNA-binding domain; Region: LytTR; smart00850 867900006718 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 867900006719 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 867900006720 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900006721 binding surface 867900006722 TPR motif; other site 867900006723 Anti-sigma-K factor rskA; Region: RskA; pfam10099 867900006724 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 867900006725 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 867900006726 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 867900006727 DNA binding residues [nucleotide binding] 867900006728 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 867900006729 E-class dimer interface [polypeptide binding]; other site 867900006730 P-class dimer interface [polypeptide binding]; other site 867900006731 active site 867900006732 Cu2+ binding site [ion binding]; other site 867900006733 Zn2+ binding site [ion binding]; other site 867900006734 YceI-like domain; Region: YceI; cl01001 867900006735 VPS10 domain; Region: VPS10; smart00602 867900006736 VPS10 domain; Region: VPS10; smart00602 867900006737 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 867900006738 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 867900006739 metal ion-dependent adhesion site (MIDAS); other site 867900006740 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 867900006741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 867900006742 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 867900006743 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 867900006744 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 867900006745 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 867900006746 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 867900006747 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 867900006748 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 867900006749 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 867900006750 Peptidase family M1; Region: Peptidase_M1; pfam01433 867900006751 Zn binding site [ion binding]; other site 867900006752 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 867900006753 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 867900006754 putative metal binding site [ion binding]; other site 867900006755 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 867900006756 Interdomain contacts; other site 867900006757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 867900006758 Major Facilitator Superfamily; Region: MFS_1; pfam07690 867900006759 putative substrate translocation pore; other site 867900006760 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 867900006761 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 867900006762 active site 867900006763 homotetramer interface [polypeptide binding]; other site 867900006764 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 867900006765 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 867900006766 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 867900006767 tyrosine decarboxylase; Region: PLN02880 867900006768 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 867900006769 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 867900006770 catalytic residue [active] 867900006771 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 867900006772 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 867900006773 active site 867900006774 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 867900006775 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 867900006776 dimer interface [polypeptide binding]; other site 867900006777 active site 867900006778 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 867900006779 3-hydroxybutyryl-CoA dehydrogenase; Region: PLN02545 867900006780 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 867900006781 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 867900006782 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 867900006783 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 867900006784 substrate binding site [chemical binding]; other site 867900006785 oxyanion hole (OAH) forming residues; other site 867900006786 trimer interface [polypeptide binding]; other site 867900006787 MarR family; Region: MarR; pfam01047 867900006788 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 867900006789 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 867900006790 acyl-activating enzyme (AAE) consensus motif; other site 867900006791 putative AMP binding site [chemical binding]; other site 867900006792 putative active site [active] 867900006793 putative CoA binding site [chemical binding]; other site 867900006794 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 867900006795 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 867900006796 DinB superfamily; Region: DinB_2; pfam12867 867900006797 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 867900006798 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 867900006799 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 867900006800 dimerization interface [polypeptide binding]; other site 867900006801 ATP binding site [chemical binding]; other site 867900006802 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 867900006803 dimerization interface [polypeptide binding]; other site 867900006804 ATP binding site [chemical binding]; other site 867900006805 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 867900006806 putative active site [active] 867900006807 catalytic triad [active] 867900006808 16S rRNA methyltransferase B; Provisional; Region: PRK14902 867900006809 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 867900006810 S-adenosylmethionine binding site [chemical binding]; other site 867900006811 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 867900006812 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 867900006813 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 867900006814 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 867900006815 DNA binding residues [nucleotide binding] 867900006816 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 867900006817 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 867900006818 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 867900006819 Walker A/P-loop; other site 867900006820 ATP binding site [chemical binding]; other site 867900006821 Q-loop/lid; other site 867900006822 ABC transporter signature motif; other site 867900006823 Walker B; other site 867900006824 D-loop; other site 867900006825 H-loop/switch region; other site 867900006826 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 867900006827 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 867900006828 active site 867900006829 substrate binding site [chemical binding]; other site 867900006830 metal binding site [ion binding]; metal-binding site 867900006831 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 867900006832 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 867900006833 Ligand binding site; other site 867900006834 Putative Catalytic site; other site 867900006835 DXD motif; other site 867900006836 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 867900006837 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 867900006838 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 867900006839 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 867900006840 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 867900006841 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 867900006842 catalytic core [active] 867900006843 polyphosphate kinase; Provisional; Region: PRK05443 867900006844 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 867900006845 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 867900006846 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 867900006847 domain interface [polypeptide binding]; other site 867900006848 active site 867900006849 catalytic site [active] 867900006850 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 867900006851 domain interface [polypeptide binding]; other site 867900006852 active site 867900006853 catalytic site [active] 867900006854 exopolyphosphatase; Region: exo_poly_only; TIGR03706 867900006855 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 867900006856 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 867900006857 active site 867900006858 dinuclear metal binding site [ion binding]; other site 867900006859 dimerization interface [polypeptide binding]; other site 867900006860 Trehalose utilisation; Region: ThuA; pfam06283 867900006861 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 867900006862 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 867900006863 Walker A motif; other site 867900006864 ATP binding site [chemical binding]; other site 867900006865 Walker B motif; other site 867900006866 arginine finger; other site 867900006867 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 867900006868 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 867900006869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 867900006870 S-adenosylmethionine binding site [chemical binding]; other site 867900006871 Protein of unknown function (DUF3822); Region: DUF3822; pfam12864 867900006872 AAA domain; Region: AAA_30; pfam13604 867900006873 Family description; Region: UvrD_C_2; pfam13538 867900006874 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 867900006875 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 867900006876 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 867900006877 Ligand binding site; other site 867900006878 oligomer interface; other site 867900006879 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 867900006880 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 867900006881 motif II; other site 867900006882 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 867900006883 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 867900006884 active site 867900006885 NAD binding site [chemical binding]; other site 867900006886 metal binding site [ion binding]; metal-binding site 867900006887 hypothetical protein; Provisional; Region: PRK06753 867900006888 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 867900006889 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 867900006890 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 867900006891 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 867900006892 putative acyl-acceptor binding pocket; other site 867900006893 hypothetical protein; Provisional; Region: PRK12378 867900006894 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 867900006895 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 867900006896 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 867900006897 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 867900006898 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 867900006899 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 867900006900 catalytic residues [active] 867900006901 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 867900006902 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 867900006903 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 867900006904 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 867900006905 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 867900006906 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 867900006907 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 867900006908 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 867900006909 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 867900006910 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 867900006911 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 867900006912 Domain of unknown function DUF20; Region: UPF0118; pfam01594 867900006913 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 867900006914 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 867900006915 UGMP family protein; Validated; Region: PRK09604 867900006916 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 867900006917 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 867900006918 Family of unknown function (DUF490); Region: DUF490; pfam04357 867900006919 Family of unknown function (DUF490); Region: DUF490; pfam04357 867900006920 6-phosphofructokinase; Provisional; Region: PRK03202 867900006921 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 867900006922 active site 867900006923 ADP/pyrophosphate binding site [chemical binding]; other site 867900006924 dimerization interface [polypeptide binding]; other site 867900006925 allosteric effector site; other site 867900006926 fructose-1,6-bisphosphate binding site; other site 867900006927 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 867900006928 glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PTZ00023 867900006929 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 867900006930 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 867900006931 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 867900006932 homotrimer interaction site [polypeptide binding]; other site 867900006933 putative active site [active] 867900006934 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 867900006935 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 867900006936 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 867900006937 active site 867900006938 metal binding site [ion binding]; metal-binding site 867900006939 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 867900006940 mce related protein; Region: MCE; pfam02470 867900006941 4Fe-4S binding domain; Region: Fer4; cl02805 867900006942 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 867900006943 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 867900006944 Cysteine-rich domain; Region: CCG; pfam02754 867900006945 Cysteine-rich domain; Region: CCG; pfam02754 867900006946 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 867900006947 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 867900006948 Beta-lactamase; Region: Beta-lactamase; cl17358 867900006949 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 867900006950 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 867900006951 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 867900006952 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 867900006953 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 867900006954 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 867900006955 ligand binding site [chemical binding]; other site 867900006956 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 867900006957 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 867900006958 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 867900006959 putative trimer interface [polypeptide binding]; other site 867900006960 putative CoA binding site [chemical binding]; other site 867900006961 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 867900006962 Bacterial sugar transferase; Region: Bac_transf; pfam02397 867900006963 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 867900006964 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 867900006965 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 867900006966 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 867900006967 CoA binding site [chemical binding]; other site 867900006968 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 867900006969 putative active site [active] 867900006970 putative metal binding site [ion binding]; other site 867900006971 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 867900006972 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 867900006973 NADP-binding site; other site 867900006974 homotetramer interface [polypeptide binding]; other site 867900006975 substrate binding site [chemical binding]; other site 867900006976 homodimer interface [polypeptide binding]; other site 867900006977 active site 867900006978 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 867900006979 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 867900006980 NADP binding site [chemical binding]; other site 867900006981 active site 867900006982 putative substrate binding site [chemical binding]; other site 867900006983 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 867900006984 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 867900006985 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 867900006986 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 867900006987 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 867900006988 active site 867900006989 dimer interface [polypeptide binding]; other site 867900006990 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 867900006991 Ligand Binding Site [chemical binding]; other site 867900006992 Molecular Tunnel; other site 867900006993 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 867900006994 trimer interface [polypeptide binding]; other site 867900006995 active site 867900006996 substrate binding site [chemical binding]; other site 867900006997 CoA binding site [chemical binding]; other site 867900006998 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 867900006999 active site 867900007000 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 867900007001 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 867900007002 active site 867900007003 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 867900007004 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 867900007005 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 867900007006 active site 867900007007 homodimer interface [polypeptide binding]; other site 867900007008 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 867900007009 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 867900007010 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 867900007011 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 867900007012 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 867900007013 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 867900007014 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 867900007015 trimer interface [polypeptide binding]; other site 867900007016 active site 867900007017 substrate binding site [chemical binding]; other site 867900007018 CoA binding site [chemical binding]; other site 867900007019 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 867900007020 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 867900007021 NAD(P) binding site [chemical binding]; other site 867900007022 homodimer interface [polypeptide binding]; other site 867900007023 substrate binding site [chemical binding]; other site 867900007024 active site 867900007025 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 867900007026 WxcM-like, C-terminal; Region: FdtA; pfam05523 867900007027 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 867900007028 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 867900007029 NAD(P) binding site [chemical binding]; other site 867900007030 active site 867900007031 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 867900007032 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 867900007033 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 867900007034 active site 867900007035 homodimer interface [polypeptide binding]; other site 867900007036 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 867900007037 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 867900007038 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 867900007039 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 867900007040 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 867900007041 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 867900007042 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 867900007043 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 867900007044 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 867900007045 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 867900007046 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 867900007047 NAD binding site [chemical binding]; other site 867900007048 substrate binding site [chemical binding]; other site 867900007049 homodimer interface [polypeptide binding]; other site 867900007050 active site 867900007051 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 867900007052 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 867900007053 inhibitor-cofactor binding pocket; inhibition site 867900007054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 867900007055 catalytic residue [active] 867900007056 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 867900007057 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 867900007058 NAD(P) binding site [chemical binding]; other site 867900007059 homodimer interface [polypeptide binding]; other site 867900007060 substrate binding site [chemical binding]; other site 867900007061 active site 867900007062 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 867900007063 SLBB domain; Region: SLBB; pfam10531 867900007064 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 867900007065 Chain length determinant protein; Region: Wzz; cl15801 867900007066 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 867900007067 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 867900007068 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 867900007069 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 867900007070 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782 867900007071 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 867900007072 PhnA protein; Region: PhnA; pfam03831 867900007073 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 867900007074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 867900007075 S-adenosylmethionine binding site [chemical binding]; other site 867900007076 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 867900007077 SmpB-tmRNA interface; other site 867900007078 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 867900007079 catalytic core [active] 867900007080 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 867900007081 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 867900007082 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 867900007083 Clp amino terminal domain; Region: Clp_N; pfam02861 867900007084 Clp amino terminal domain; Region: Clp_N; pfam02861 867900007085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 867900007086 Walker A motif; other site 867900007087 ATP binding site [chemical binding]; other site 867900007088 Walker B motif; other site 867900007089 arginine finger; other site 867900007090 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 867900007091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 867900007092 Walker A motif; other site 867900007093 ATP binding site [chemical binding]; other site 867900007094 Walker B motif; other site 867900007095 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 867900007096 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 867900007097 fumarylacetoacetase; Region: PLN02856 867900007098 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 867900007099 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 867900007100 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 867900007101 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 867900007102 dimer interface [polypeptide binding]; other site 867900007103 active site 867900007104 glycine-pyridoxal phosphate binding site [chemical binding]; other site 867900007105 folate binding site [chemical binding]; other site 867900007106 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 867900007107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900007108 active site 867900007109 phosphorylation site [posttranslational modification] 867900007110 intermolecular recognition site; other site 867900007111 dimerization interface [polypeptide binding]; other site 867900007112 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900007113 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900007114 binding surface 867900007115 TPR motif; other site 867900007116 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900007117 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 867900007118 Histidine kinase; Region: HisKA_3; pfam07730 867900007119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900007120 ATP binding site [chemical binding]; other site 867900007121 Mg2+ binding site [ion binding]; other site 867900007122 G-X-G motif; other site 867900007123 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 867900007124 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 867900007125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900007126 active site 867900007127 phosphorylation site [posttranslational modification] 867900007128 intermolecular recognition site; other site 867900007129 dimerization interface [polypeptide binding]; other site 867900007130 LytTr DNA-binding domain; Region: LytTR; smart00850 867900007131 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 867900007132 active site 867900007133 Glutamine cyclotransferase; Region: Glu_cyclase_2; pfam05096 867900007134 short chain dehydrogenase; Provisional; Region: PRK06179 867900007135 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 867900007136 NADP binding site [chemical binding]; other site 867900007137 active site 867900007138 steroid binding site; other site 867900007139 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 867900007140 active site 867900007141 intersubunit interactions; other site 867900007142 catalytic residue [active] 867900007143 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 867900007144 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 867900007145 Walker A/P-loop; other site 867900007146 ATP binding site [chemical binding]; other site 867900007147 Q-loop/lid; other site 867900007148 ABC transporter signature motif; other site 867900007149 Walker B; other site 867900007150 D-loop; other site 867900007151 H-loop/switch region; other site 867900007152 ABC transporter; Region: ABC_tran_2; pfam12848 867900007153 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 867900007154 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 867900007155 Fasciclin domain; Region: Fasciclin; pfam02469 867900007156 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 867900007157 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 867900007158 putative tRNA-binding site [nucleotide binding]; other site 867900007159 B3/4 domain; Region: B3_4; pfam03483 867900007160 tRNA synthetase B5 domain; Region: B5; pfam03484 867900007161 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 867900007162 dimer interface [polypeptide binding]; other site 867900007163 motif 1; other site 867900007164 motif 3; other site 867900007165 motif 2; other site 867900007166 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 867900007167 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 867900007168 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 867900007169 catalytic residues [active] 867900007170 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 867900007171 tartrate dehydrogenase; Region: TTC; TIGR02089 867900007172 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 867900007173 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 867900007174 active site 867900007175 catalytic residues [active] 867900007176 metal binding site [ion binding]; metal-binding site 867900007177 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 867900007178 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 867900007179 active site 867900007180 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 867900007181 oligomerization interface [polypeptide binding]; other site 867900007182 active site 867900007183 metal binding site [ion binding]; metal-binding site 867900007184 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 867900007185 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 867900007186 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 867900007187 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 867900007188 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 867900007189 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 867900007190 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 867900007191 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 867900007192 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 867900007193 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 867900007194 nucleotide binding site [chemical binding]; other site 867900007195 NEF interaction site [polypeptide binding]; other site 867900007196 SBD interface [polypeptide binding]; other site 867900007197 CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with...; Region: CIDE_N; cl02541 867900007198 putative heterodimer interaction sites [polypeptide binding]; other site 867900007199 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 867900007200 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 867900007201 Serine hydrolase (FSH1); Region: FSH1; pfam03959 867900007202 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 867900007203 CoenzymeA binding site [chemical binding]; other site 867900007204 subunit interaction site [polypeptide binding]; other site 867900007205 PHB binding site; other site 867900007206 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 867900007207 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 867900007208 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 867900007209 dimer interface [polypeptide binding]; other site 867900007210 tetramer interface [polypeptide binding]; other site 867900007211 PYR/PP interface [polypeptide binding]; other site 867900007212 TPP binding site [chemical binding]; other site 867900007213 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 867900007214 TPP-binding site; other site 867900007215 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 867900007216 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 867900007217 S1 domain; Region: S1_2; pfam13509 867900007218 Protein of unknown function (DUF2582); Region: DUF2582; pfam10771 867900007219 Sporulation related domain; Region: SPOR; cl10051 867900007220 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 867900007221 UbiA prenyltransferase family; Region: UbiA; pfam01040 867900007222 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 867900007223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900007224 active site 867900007225 phosphorylation site [posttranslational modification] 867900007226 intermolecular recognition site; other site 867900007227 dimerization interface [polypeptide binding]; other site 867900007228 LytTr DNA-binding domain; Region: LytTR; smart00850 867900007229 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 867900007230 binding surface 867900007231 TPR motif; other site 867900007232 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 867900007233 Histidine kinase; Region: HisKA_2; pfam07568 867900007234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900007235 ATP binding site [chemical binding]; other site 867900007236 Mg2+ binding site [ion binding]; other site 867900007237 G-X-G motif; other site 867900007238 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 867900007239 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 867900007240 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 867900007241 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 867900007242 active site 867900007243 CAAX protease self-immunity; Region: Abi; pfam02517 867900007244 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 867900007245 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 867900007246 acyl-activating enzyme (AAE) consensus motif; other site 867900007247 AMP binding site [chemical binding]; other site 867900007248 active site 867900007249 CoA binding site [chemical binding]; other site 867900007250 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 867900007251 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 867900007252 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900007253 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 867900007254 von Willebrand factor; Region: vWF_A; pfam12450 867900007255 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 867900007256 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 867900007257 metal ion-dependent adhesion site (MIDAS); other site 867900007258 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 867900007259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 867900007260 putative substrate translocation pore; other site 867900007261 Major Facilitator Superfamily; Region: MFS_1; pfam07690 867900007262 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 867900007263 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 867900007264 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 867900007265 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 867900007266 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 867900007267 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 867900007268 Walker A/P-loop; other site 867900007269 ATP binding site [chemical binding]; other site 867900007270 Q-loop/lid; other site 867900007271 ABC transporter signature motif; other site 867900007272 Walker B; other site 867900007273 D-loop; other site 867900007274 H-loop/switch region; other site 867900007275 ABC transporter; Region: ABC_tran_2; pfam12848 867900007276 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 867900007277 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 867900007278 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 867900007279 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 867900007280 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 867900007281 Coenzyme A binding pocket [chemical binding]; other site 867900007282 fumarate hydratase; Reviewed; Region: fumC; PRK00485 867900007283 Class II fumarases; Region: Fumarase_classII; cd01362 867900007284 active site 867900007285 tetramer interface [polypeptide binding]; other site 867900007286 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 867900007287 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 867900007288 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900007289 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 867900007290 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 867900007291 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900007292 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 867900007293 ArsC family; Region: ArsC; pfam03960 867900007294 catalytic residues [active] 867900007295 peptide chain release factor 2; Validated; Region: prfB; PRK00578 867900007296 PCRF domain; Region: PCRF; pfam03462 867900007297 RF-1 domain; Region: RF-1; pfam00472 867900007298 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 867900007299 active site 867900007300 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 867900007301 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 867900007302 tetramer interface [polypeptide binding]; other site 867900007303 pyridoxal 5'-phosphate binding site [chemical binding]; other site 867900007304 catalytic residue [active] 867900007305 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 867900007306 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 867900007307 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 867900007308 ligand binding site [chemical binding]; other site 867900007309 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 867900007310 hypothetical protein; Provisional; Region: PRK14623 867900007311 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 867900007312 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 867900007313 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 867900007314 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 867900007315 dimer interface [polypeptide binding]; other site 867900007316 pyridoxal 5'-phosphate binding site [chemical binding]; other site 867900007317 catalytic residue [active] 867900007318 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 867900007319 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 867900007320 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 867900007321 catalytic residue [active] 867900007322 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 867900007323 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 867900007324 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 867900007325 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 867900007326 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 867900007327 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 867900007328 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 867900007329 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 867900007330 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 867900007331 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 867900007332 Walker A/P-loop; other site 867900007333 ATP binding site [chemical binding]; other site 867900007334 Q-loop/lid; other site 867900007335 ABC transporter signature motif; other site 867900007336 Walker B; other site 867900007337 D-loop; other site 867900007338 H-loop/switch region; other site 867900007339 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 867900007340 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 867900007341 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 867900007342 DNA binding residues [nucleotide binding] 867900007343 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 867900007344 endonuclease III; Region: ENDO3c; smart00478 867900007345 minor groove reading motif; other site 867900007346 helix-hairpin-helix signature motif; other site 867900007347 substrate binding pocket [chemical binding]; other site 867900007348 active site 867900007349 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 867900007350 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 867900007351 catalytic triad [active] 867900007352 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 867900007353 putative hydrolase; Provisional; Region: PRK02113 867900007354 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 867900007355 Predicted esterase [General function prediction only]; Region: COG0400 867900007356 putative hydrolase; Provisional; Region: PRK11460 867900007357 dihydroorotase; Validated; Region: pyrC; PRK09357 867900007358 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 867900007359 active site 867900007360 von Willebrand factor type A domain; Region: VWA_2; pfam13519 867900007361 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 867900007362 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 867900007363 active site 867900007364 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 867900007365 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501 867900007366 active site 867900007367 catalytic triad [active] 867900007368 oxyanion hole [active] 867900007369 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 867900007370 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 867900007371 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 867900007372 PYR/PP interface [polypeptide binding]; other site 867900007373 dimer interface [polypeptide binding]; other site 867900007374 TPP binding site [chemical binding]; other site 867900007375 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 867900007376 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 867900007377 TPP-binding site [chemical binding]; other site 867900007378 dimer interface [polypeptide binding]; other site 867900007379 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 867900007380 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 867900007381 putative valine binding site [chemical binding]; other site 867900007382 dimer interface [polypeptide binding]; other site 867900007383 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 867900007384 ketol-acid reductoisomerase; Validated; Region: PRK05225 867900007385 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 867900007386 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 867900007387 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 867900007388 threonine dehydratase; Validated; Region: PRK08639 867900007389 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 867900007390 tetramer interface [polypeptide binding]; other site 867900007391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 867900007392 catalytic residue [active] 867900007393 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 867900007394 putative Ile/Val binding site [chemical binding]; other site 867900007395 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 867900007396 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 867900007397 tetrameric interface [polypeptide binding]; other site 867900007398 activator binding site; other site 867900007399 NADP binding site [chemical binding]; other site 867900007400 substrate binding site [chemical binding]; other site 867900007401 catalytic residues [active] 867900007402 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900007403 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 867900007404 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900007405 MFS transport protein AraJ; Provisional; Region: PRK10091 867900007406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 867900007407 putative substrate translocation pore; other site 867900007408 Repair protein; Region: Repair_PSII; pfam04536 867900007409 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 867900007410 tartrate dehydrogenase; Region: TTC; TIGR02089 867900007411 2-isopropylmalate synthase; Validated; Region: PRK00915 867900007412 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 867900007413 active site 867900007414 catalytic residues [active] 867900007415 metal binding site [ion binding]; metal-binding site 867900007416 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 867900007417 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 867900007418 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 867900007419 substrate binding site [chemical binding]; other site 867900007420 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 867900007421 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 867900007422 substrate binding site [chemical binding]; other site 867900007423 ligand binding site [chemical binding]; other site 867900007424 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 867900007425 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 867900007426 generic binding surface II; other site 867900007427 ssDNA binding site; other site 867900007428 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 867900007429 ATP binding site [chemical binding]; other site 867900007430 putative Mg++ binding site [ion binding]; other site 867900007431 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 867900007432 nucleotide binding region [chemical binding]; other site 867900007433 ATP-binding site [chemical binding]; other site 867900007434 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 867900007435 Zn binding site [ion binding]; other site 867900007436 Patatin-like phospholipase; Region: Patatin; pfam01734 867900007437 Patatin-like phospholipase; Region: Patatin; pfam01734 867900007438 active site 867900007439 nucleophile elbow; other site 867900007440 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 867900007441 active site 867900007442 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 867900007443 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 867900007444 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 867900007445 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 867900007446 active site 867900007447 FMN binding site [chemical binding]; other site 867900007448 substrate binding site [chemical binding]; other site 867900007449 3Fe-4S cluster binding site [ion binding]; other site 867900007450 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 867900007451 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 867900007452 metal binding site [ion binding]; metal-binding site 867900007453 putative dimer interface [polypeptide binding]; other site 867900007454 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 867900007455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 867900007456 Coenzyme A binding pocket [chemical binding]; other site 867900007457 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 867900007458 Part of AAA domain; Region: AAA_19; pfam13245 867900007459 Family description; Region: UvrD_C_2; pfam13538 867900007460 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 867900007461 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 867900007462 ligand binding site [chemical binding]; other site 867900007463 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 867900007464 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 867900007465 Probable Catalytic site; other site 867900007466 metal-binding site 867900007467 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 867900007468 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 867900007469 DNA polymerase III, delta subunit; Region: holA; TIGR01128 867900007470 DoxX; Region: DoxX; pfam07681 867900007471 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 867900007472 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 867900007473 tetramer interface [polypeptide binding]; other site 867900007474 TPP-binding site [chemical binding]; other site 867900007475 heterodimer interface [polypeptide binding]; other site 867900007476 phosphorylation loop region [posttranslational modification] 867900007477 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 867900007478 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 867900007479 PYR/PP interface [polypeptide binding]; other site 867900007480 dimer interface [polypeptide binding]; other site 867900007481 TPP binding site [chemical binding]; other site 867900007482 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 867900007483 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 867900007484 Zn binding site [ion binding]; other site 867900007485 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 867900007486 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 867900007487 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 867900007488 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 867900007489 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 867900007490 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 867900007491 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 867900007492 non-specific DNA binding site [nucleotide binding]; other site 867900007493 salt bridge; other site 867900007494 sequence-specific DNA binding site [nucleotide binding]; other site 867900007495 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 867900007496 Catalytic site [active] 867900007497 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 867900007498 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 867900007499 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 867900007500 Soluble P-type ATPase [General function prediction only]; Region: COG4087 867900007501 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 867900007502 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 867900007503 ligand binding site [chemical binding]; other site 867900007504 flexible hinge region; other site 867900007505 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 867900007506 Pirin-related protein [General function prediction only]; Region: COG1741 867900007507 Pirin; Region: Pirin; pfam02678 867900007508 Pirin-related protein [General function prediction only]; Region: COG1741 867900007509 Pirin; Region: Pirin; pfam02678 867900007510 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 867900007511 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 867900007512 EamA-like transporter family; Region: EamA; pfam00892 867900007513 EamA-like transporter family; Region: EamA; pfam00892 867900007514 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 867900007515 ATP binding site [chemical binding]; other site 867900007516 putative Mg++ binding site [ion binding]; other site 867900007517 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 867900007518 nucleotide binding region [chemical binding]; other site 867900007519 ATP-binding site [chemical binding]; other site 867900007520 Beta-lactamase; Region: Beta-lactamase; pfam00144 867900007521 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 867900007522 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 867900007523 putative active site [active] 867900007524 Zn binding site [ion binding]; other site 867900007525 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 867900007526 von Willebrand factor type A domain; Region: VWA_2; pfam13519 867900007527 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 867900007528 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 867900007529 catalytic loop [active] 867900007530 iron binding site [ion binding]; other site 867900007531 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 867900007532 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 867900007533 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 867900007534 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 867900007535 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 867900007536 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 867900007537 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 867900007538 MoaE interaction surface [polypeptide binding]; other site 867900007539 MoeB interaction surface [polypeptide binding]; other site 867900007540 thiocarboxylated glycine; other site 867900007541 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 867900007542 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 867900007543 FeS/SAM binding site; other site 867900007544 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 867900007545 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 867900007546 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 867900007547 GTP binding site; other site 867900007548 hypothetical protein; Validated; Region: PRK07411 867900007549 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 867900007550 ATP binding site [chemical binding]; other site 867900007551 substrate interface [chemical binding]; other site 867900007552 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 867900007553 active site residue [active] 867900007554 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 867900007555 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 867900007556 dimer interface [polypeptide binding]; other site 867900007557 putative functional site; other site 867900007558 putative MPT binding site; other site 867900007559 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 867900007560 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 867900007561 XdhC Rossmann domain; Region: XdhC_C; pfam13478 867900007562 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 867900007563 Ligand binding site; other site 867900007564 metal-binding site 867900007565 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 867900007566 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 867900007567 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 867900007568 putative uracil binding site [chemical binding]; other site 867900007569 putative active site [active] 867900007570 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 867900007571 DNA-binding site [nucleotide binding]; DNA binding site 867900007572 RNA-binding motif; other site 867900007573 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 867900007574 DEAD-like helicases superfamily; Region: DEXDc; smart00487 867900007575 ATP binding site [chemical binding]; other site 867900007576 Mg++ binding site [ion binding]; other site 867900007577 motif III; other site 867900007578 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 867900007579 nucleotide binding region [chemical binding]; other site 867900007580 ATP-binding site [chemical binding]; other site 867900007581 Protein of unknown function, DUF479; Region: DUF479; cl01203 867900007582 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 867900007583 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 867900007584 active site 867900007585 substrate binding site [chemical binding]; other site 867900007586 metal binding site [ion binding]; metal-binding site 867900007587 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 867900007588 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 867900007589 putative acyl-acceptor binding pocket; other site 867900007590 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 867900007591 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 867900007592 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 867900007593 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 867900007594 catalytic residues [active] 867900007595 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 867900007596 FAD binding domain; Region: FAD_binding_4; pfam01565 867900007597 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 867900007598 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 867900007599 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 867900007600 putative active site [active] 867900007601 putative metal binding site [ion binding]; other site 867900007602 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 867900007603 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 867900007604 Tetramer interface [polypeptide binding]; other site 867900007605 active site 867900007606 FMN-binding site [chemical binding]; other site 867900007607 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 867900007608 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 867900007609 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 867900007610 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 867900007611 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900007612 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 867900007613 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 867900007614 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 867900007615 Mechanosensitive ion channel; Region: MS_channel; pfam00924 867900007616 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 867900007617 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900007618 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900007619 binding surface 867900007620 TPR motif; other site 867900007621 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900007622 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900007623 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900007624 TPR motif; other site 867900007625 binding surface 867900007626 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900007627 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900007628 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 867900007629 MutS domain III; Region: MutS_III; pfam05192 867900007630 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 867900007631 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 867900007632 Walker A/P-loop; other site 867900007633 ATP binding site [chemical binding]; other site 867900007634 Q-loop/lid; other site 867900007635 ABC transporter signature motif; other site 867900007636 Walker B; other site 867900007637 D-loop; other site 867900007638 H-loop/switch region; other site 867900007639 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 867900007640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 867900007641 S-adenosylmethionine binding site [chemical binding]; other site 867900007642 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 867900007643 DEAD-like helicases superfamily; Region: DEXDc; smart00487 867900007644 ATP binding site [chemical binding]; other site 867900007645 Mg++ binding site [ion binding]; other site 867900007646 motif III; other site 867900007647 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 867900007648 nucleotide binding region [chemical binding]; other site 867900007649 ATP-binding site [chemical binding]; other site 867900007650 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 867900007651 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 867900007652 ATP binding site [chemical binding]; other site 867900007653 putative Mg++ binding site [ion binding]; other site 867900007654 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 867900007655 nucleotide binding region [chemical binding]; other site 867900007656 ATP-binding site [chemical binding]; other site 867900007657 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 867900007658 RNA binding site [nucleotide binding]; other site 867900007659 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 867900007660 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 867900007661 NAD(P) binding site [chemical binding]; other site 867900007662 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 867900007663 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 867900007664 active site 867900007665 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 867900007666 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 867900007667 putative catalytic residues [active] 867900007668 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 867900007669 DNA-binding site [nucleotide binding]; DNA binding site 867900007670 RNA-binding motif; other site 867900007671 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 867900007672 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 867900007673 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 867900007674 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 867900007675 HSP70 interaction site [polypeptide binding]; other site 867900007676 KTSC domain; Region: KTSC; pfam13619 867900007677 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 867900007678 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 867900007679 potential catalytic triad [active] 867900007680 conserved cys residue [active] 867900007681 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 867900007682 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 867900007683 dimer interface [polypeptide binding]; other site 867900007684 active site 867900007685 metal binding site [ion binding]; metal-binding site 867900007686 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 867900007687 Prostaglandin dehydrogenases; Region: PGDH; cd05288 867900007688 NAD(P) binding site [chemical binding]; other site 867900007689 substrate binding site [chemical binding]; other site 867900007690 dimer interface [polypeptide binding]; other site 867900007691 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 867900007692 dimer interface [polypeptide binding]; other site 867900007693 FMN binding site [chemical binding]; other site 867900007694 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 867900007695 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 867900007696 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 867900007697 pseudouridine synthase; Region: TIGR00093 867900007698 active site 867900007699 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 867900007700 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 867900007701 active site 867900007702 Zn binding site [ion binding]; other site 867900007703 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 867900007704 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 867900007705 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 867900007706 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 867900007707 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 867900007708 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900007709 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 867900007710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900007711 active site 867900007712 phosphorylation site [posttranslational modification] 867900007713 intermolecular recognition site; other site 867900007714 dimerization interface [polypeptide binding]; other site 867900007715 LytTr DNA-binding domain; Region: LytTR; smart00850 867900007716 Histidine kinase; Region: His_kinase; pfam06580 867900007717 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 867900007718 YHYH protein; Region: YHYH; pfam14240 867900007719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 867900007720 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 867900007721 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 867900007722 Cu(I) binding site [ion binding]; other site 867900007723 EamA-like transporter family; Region: EamA; pfam00892 867900007724 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 867900007725 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 867900007726 Domain of unknown function (DUF1853); Region: DUF1853; cl01545 867900007727 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 867900007728 active site 867900007729 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 867900007730 active site 867900007731 catalytic residues [active] 867900007732 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 867900007733 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 867900007734 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 867900007735 putative dimer interface [polypeptide binding]; other site 867900007736 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 867900007737 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 867900007738 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 867900007739 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 867900007740 dimer interface [polypeptide binding]; other site 867900007741 FMN binding site [chemical binding]; other site 867900007742 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 867900007743 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 867900007744 putative NAD(P) binding site [chemical binding]; other site 867900007745 dimer interface [polypeptide binding]; other site 867900007746 Cupin domain; Region: Cupin_2; pfam07883 867900007747 Cupin domain; Region: Cupin_2; cl17218 867900007748 Major royal jelly protein; Region: MRJP; pfam03022 867900007749 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 867900007750 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 867900007751 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 867900007752 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 867900007753 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 867900007754 substrate binding site [chemical binding]; other site 867900007755 oxyanion hole (OAH) forming residues; other site 867900007756 trimer interface [polypeptide binding]; other site 867900007757 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 867900007758 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 867900007759 putative NAD(P) binding site [chemical binding]; other site 867900007760 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 867900007761 short chain dehydrogenase; Provisional; Region: PRK12829 867900007762 NAD(P) binding site [chemical binding]; other site 867900007763 active site 867900007764 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 867900007765 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 867900007766 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 867900007767 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 867900007768 TrkA-N domain; Region: TrkA_N; pfam02254 867900007769 TfoX N-terminal domain; Region: TfoX_N; pfam04993 867900007770 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 867900007771 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 867900007772 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 867900007773 FMN binding site [chemical binding]; other site 867900007774 active site 867900007775 substrate binding site [chemical binding]; other site 867900007776 catalytic residue [active] 867900007777 CotH protein; Region: CotH; pfam08757 867900007778 O-Antigen ligase; Region: Wzy_C; cl04850 867900007779 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 867900007780 nudix motif; other site 867900007781 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 867900007782 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 867900007783 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 867900007784 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 867900007785 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 867900007786 Walker A/P-loop; other site 867900007787 ATP binding site [chemical binding]; other site 867900007788 Q-loop/lid; other site 867900007789 ABC transporter signature motif; other site 867900007790 Walker B; other site 867900007791 D-loop; other site 867900007792 H-loop/switch region; other site 867900007793 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 867900007794 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 867900007795 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 867900007796 TM-ABC transporter signature motif; other site 867900007797 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 867900007798 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 867900007799 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 867900007800 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 867900007801 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 867900007802 putative substrate binding site [chemical binding]; other site 867900007803 putative ATP binding site [chemical binding]; other site 867900007804 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 867900007805 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 867900007806 Bacterial transcriptional repressor; Region: TetR; pfam13972 867900007807 Protein of unknown function (DUF962); Region: DUF962; cl01879 867900007808 Outer membrane efflux protein; Region: OEP; pfam02321 867900007809 Outer membrane efflux protein; Region: OEP; pfam02321 867900007810 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 867900007811 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 867900007812 HlyD family secretion protein; Region: HlyD_3; pfam13437 867900007813 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 867900007814 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 867900007815 Walker A/P-loop; other site 867900007816 ATP binding site [chemical binding]; other site 867900007817 Q-loop/lid; other site 867900007818 ABC transporter signature motif; other site 867900007819 Walker B; other site 867900007820 D-loop; other site 867900007821 H-loop/switch region; other site 867900007822 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 867900007823 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 867900007824 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 867900007825 Fatty acid desaturase; Region: FA_desaturase; pfam00487 867900007826 putative di-iron ligands [ion binding]; other site 867900007827 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 867900007828 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 867900007829 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 867900007830 ligand binding site [chemical binding]; other site 867900007831 flexible hinge region; other site 867900007832 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 867900007833 DNA-binding site [nucleotide binding]; DNA binding site 867900007834 RNA-binding motif; other site 867900007835 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 867900007836 nucleoside/Zn binding site; other site 867900007837 dimer interface [polypeptide binding]; other site 867900007838 catalytic motif [active] 867900007839 Predicted membrane protein [Function unknown]; Region: COG2323 867900007840 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 867900007841 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 867900007842 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 867900007843 FeS/SAM binding site; other site 867900007844 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 867900007845 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 867900007846 non-specific DNA binding site [nucleotide binding]; other site 867900007847 salt bridge; other site 867900007848 sequence-specific DNA binding site [nucleotide binding]; other site 867900007849 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 867900007850 Catalytic site [active] 867900007851 AAA domain; Region: AAA_23; pfam13476 867900007852 P-loop containing region of AAA domain; Region: AAA_29; cl17516 867900007853 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 867900007854 putative active site [active] 867900007855 putative metal-binding site [ion binding]; other site 867900007856 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 867900007857 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 867900007858 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 867900007859 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 867900007860 Mrr N-terminal domain; Region: Mrr_N; pfam14338 867900007861 Restriction endonuclease; Region: Mrr_cat; pfam04471 867900007862 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 867900007863 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 867900007864 active site 867900007865 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 867900007866 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 867900007867 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 867900007868 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 867900007869 active site 867900007870 catalytic residues [active] 867900007871 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 867900007872 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 867900007873 active site 867900007874 Family description; Region: VCBS; pfam13517 867900007875 Family description; Region: VCBS; pfam13517 867900007876 Family description; Region: VCBS; pfam13517 867900007877 Family description; Region: VCBS; pfam13517 867900007878 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 867900007879 Family description; Region: VCBS; pfam13517 867900007880 Family description; Region: VCBS; pfam13517 867900007881 Family description; Region: VCBS; pfam13517 867900007882 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 867900007883 30S subunit binding site; other site 867900007884 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 867900007885 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 867900007886 tetramer interface [polypeptide binding]; other site 867900007887 TPP-binding site [chemical binding]; other site 867900007888 heterodimer interface [polypeptide binding]; other site 867900007889 phosphorylation loop region [posttranslational modification] 867900007890 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 867900007891 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 867900007892 alpha subunit interface [polypeptide binding]; other site 867900007893 TPP binding site [chemical binding]; other site 867900007894 heterodimer interface [polypeptide binding]; other site 867900007895 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 867900007896 oxidase reductase; Provisional; Region: PTZ00273 867900007897 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 867900007898 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 867900007899 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 867900007900 putative rRNA binding site [nucleotide binding]; other site 867900007901 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 867900007902 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 867900007903 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 867900007904 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 867900007905 ligand binding site [chemical binding]; other site 867900007906 active site 867900007907 UGI interface [polypeptide binding]; other site 867900007908 catalytic site [active] 867900007909 Predicted membrane protein [Function unknown]; Region: COG1288 867900007910 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 867900007911 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 867900007912 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 867900007913 ATP binding site [chemical binding]; other site 867900007914 putative Mg++ binding site [ion binding]; other site 867900007915 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 867900007916 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 867900007917 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 867900007918 substrate binding site [chemical binding]; other site 867900007919 oxyanion hole (OAH) forming residues; other site 867900007920 trimer interface [polypeptide binding]; other site 867900007921 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 867900007922 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 867900007923 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 867900007924 ATP binding site [chemical binding]; other site 867900007925 putative Mg++ binding site [ion binding]; other site 867900007926 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 867900007927 nucleotide binding region [chemical binding]; other site 867900007928 ATP-binding site [chemical binding]; other site 867900007929 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 867900007930 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 867900007931 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 867900007932 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 867900007933 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 867900007934 DNA binding residues [nucleotide binding] 867900007935 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 867900007936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900007937 ATP binding site [chemical binding]; other site 867900007938 Mg2+ binding site [ion binding]; other site 867900007939 G-X-G motif; other site 867900007940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900007941 active site 867900007942 phosphorylation site [posttranslational modification] 867900007943 intermolecular recognition site; other site 867900007944 dimerization interface [polypeptide binding]; other site 867900007945 Hpt domain; Region: Hpt; pfam01627 867900007946 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 867900007947 active site 2 [active] 867900007948 active site 1 [active] 867900007949 Protein of unknown function DUF72; Region: DUF72; pfam01904 867900007950 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 867900007951 serine O-acetyltransferase; Region: cysE; TIGR01172 867900007952 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 867900007953 trimer interface [polypeptide binding]; other site 867900007954 active site 867900007955 substrate binding site [chemical binding]; other site 867900007956 CoA binding site [chemical binding]; other site 867900007957 cysteine synthase B; Region: cysM; TIGR01138 867900007958 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 867900007959 dimer interface [polypeptide binding]; other site 867900007960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 867900007961 catalytic residue [active] 867900007962 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 867900007963 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 867900007964 active site 867900007965 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 867900007966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900007967 active site 867900007968 phosphorylation site [posttranslational modification] 867900007969 intermolecular recognition site; other site 867900007970 dimerization interface [polypeptide binding]; other site 867900007971 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 867900007972 DNA binding site [nucleotide binding] 867900007973 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 867900007974 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 867900007975 dimerization interface [polypeptide binding]; other site 867900007976 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 867900007977 dimer interface [polypeptide binding]; other site 867900007978 phosphorylation site [posttranslational modification] 867900007979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900007980 ATP binding site [chemical binding]; other site 867900007981 Mg2+ binding site [ion binding]; other site 867900007982 G-X-G motif; other site 867900007983 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 867900007984 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 867900007985 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 867900007986 metal binding site [ion binding]; metal-binding site 867900007987 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 867900007988 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 867900007989 substrate binding site [chemical binding]; other site 867900007990 glutamase interaction surface [polypeptide binding]; other site 867900007991 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 867900007992 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 867900007993 catalytic residues [active] 867900007994 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 867900007995 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 867900007996 putative active site [active] 867900007997 oxyanion strand; other site 867900007998 catalytic triad [active] 867900007999 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 867900008000 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 867900008001 active site 867900008002 motif I; other site 867900008003 motif II; other site 867900008004 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 867900008005 putative active site pocket [active] 867900008006 4-fold oligomerization interface [polypeptide binding]; other site 867900008007 metal binding residues [ion binding]; metal-binding site 867900008008 3-fold/trimer interface [polypeptide binding]; other site 867900008009 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 867900008010 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 867900008011 pyridoxal 5'-phosphate binding site [chemical binding]; other site 867900008012 homodimer interface [polypeptide binding]; other site 867900008013 catalytic residue [active] 867900008014 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 867900008015 histidinol dehydrogenase; Region: hisD; TIGR00069 867900008016 NAD binding site [chemical binding]; other site 867900008017 dimerization interface [polypeptide binding]; other site 867900008018 product binding site; other site 867900008019 substrate binding site [chemical binding]; other site 867900008020 zinc binding site [ion binding]; other site 867900008021 catalytic residues [active] 867900008022 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 867900008023 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 867900008024 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 867900008025 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 867900008026 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_1; cd03400 867900008027 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 867900008028 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 867900008029 metal ion-dependent adhesion site (MIDAS); other site 867900008030 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 867900008031 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 867900008032 NAD(P) binding site [chemical binding]; other site 867900008033 homotetramer interface [polypeptide binding]; other site 867900008034 homodimer interface [polypeptide binding]; other site 867900008035 active site 867900008036 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 867900008037 CoA binding domain; Region: CoA_binding; smart00881 867900008038 CoA-ligase; Region: Ligase_CoA; pfam00549 867900008039 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 867900008040 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 867900008041 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 867900008042 trimer interface [polypeptide binding]; other site 867900008043 active site 867900008044 UDP-GlcNAc binding site [chemical binding]; other site 867900008045 lipid binding site [chemical binding]; lipid-binding site 867900008046 elongation factor P; Validated; Region: PRK00529 867900008047 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 867900008048 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 867900008049 RNA binding site [nucleotide binding]; other site 867900008050 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 867900008051 RNA binding site [nucleotide binding]; other site 867900008052 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 867900008053 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 867900008054 active site 867900008055 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 867900008056 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 867900008057 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 867900008058 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 867900008059 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 867900008060 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 867900008061 trimer interface [polypeptide binding]; other site 867900008062 active site 867900008063 UDP-GlcNAc binding site [chemical binding]; other site 867900008064 lipid binding site [chemical binding]; lipid-binding site 867900008065 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 867900008066 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 867900008067 Zn2+ binding site [ion binding]; other site 867900008068 Mg2+ binding site [ion binding]; other site 867900008069 Response regulator receiver domain; Region: Response_reg; pfam00072 867900008070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900008071 active site 867900008072 phosphorylation site [posttranslational modification] 867900008073 intermolecular recognition site; other site 867900008074 dimerization interface [polypeptide binding]; other site 867900008075 PglZ domain; Region: PglZ; pfam08665 867900008076 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 867900008077 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 867900008078 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 867900008079 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 867900008080 hexamer interface [polypeptide binding]; other site 867900008081 ligand binding site [chemical binding]; other site 867900008082 putative active site [active] 867900008083 NAD(P) binding site [chemical binding]; other site 867900008084 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 867900008085 Proline dehydrogenase; Region: Pro_dh; cl03282 867900008086 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 867900008087 active site 867900008088 dimer interface [polypeptide binding]; other site 867900008089 metal binding site [ion binding]; metal-binding site 867900008090 DinB superfamily; Region: DinB_2; pfam12867 867900008091 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 867900008092 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 867900008093 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 867900008094 putative DNA binding site [nucleotide binding]; other site 867900008095 putative Zn2+ binding site [ion binding]; other site 867900008096 AsnC family; Region: AsnC_trans_reg; pfam01037 867900008097 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 867900008098 putative active site [active] 867900008099 Zn binding site [ion binding]; other site 867900008100 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 867900008101 non-specific DNA binding site [nucleotide binding]; other site 867900008102 salt bridge; other site 867900008103 sequence-specific DNA binding site [nucleotide binding]; other site 867900008104 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 867900008105 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 867900008106 DNA topoisomerase IV subunit A; Provisional; Region: PRK12758 867900008107 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 867900008108 CAP-like domain; other site 867900008109 active site 867900008110 primary dimer interface [polypeptide binding]; other site 867900008111 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 867900008112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900008113 ATP binding site [chemical binding]; other site 867900008114 Mg2+ binding site [ion binding]; other site 867900008115 G-X-G motif; other site 867900008116 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 867900008117 ATP binding site [chemical binding]; other site 867900008118 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 867900008119 active site 867900008120 putative metal-binding site [ion binding]; other site 867900008121 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 867900008122 GTP-binding protein YchF; Reviewed; Region: PRK09601 867900008123 YchF GTPase; Region: YchF; cd01900 867900008124 G1 box; other site 867900008125 GTP/Mg2+ binding site [chemical binding]; other site 867900008126 Switch I region; other site 867900008127 G2 box; other site 867900008128 Switch II region; other site 867900008129 G3 box; other site 867900008130 G4 box; other site 867900008131 G5 box; other site 867900008132 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 867900008133 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900008134 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 867900008135 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 867900008136 N-terminal plug; other site 867900008137 ligand-binding site [chemical binding]; other site 867900008138 4Fe-4S binding domain; Region: Fer4; pfam00037 867900008139 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 867900008140 NAD(P) binding site [chemical binding]; other site 867900008141 catalytic residues [active] 867900008142 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 867900008143 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 867900008144 catalytic residue [active] 867900008145 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 867900008146 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 867900008147 putative ligand binding site [chemical binding]; other site 867900008148 NAD binding site [chemical binding]; other site 867900008149 dimerization interface [polypeptide binding]; other site 867900008150 catalytic site [active] 867900008151 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 867900008152 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 867900008153 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 867900008154 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 867900008155 DNA binding residues [nucleotide binding] 867900008156 FecR protein; Region: FecR; pfam04773 867900008157 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 867900008158 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900008159 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 867900008160 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900008161 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 867900008162 starch binding outer membrane protein SusD; Region: SusD; cl17845 867900008163 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 867900008164 active site 867900008165 metal binding site [ion binding]; metal-binding site 867900008166 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 867900008167 sulfite oxidase; Provisional; Region: PLN00177 867900008168 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 867900008169 Moco binding site; other site 867900008170 metal coordination site [ion binding]; other site 867900008171 dimerization interface [polypeptide binding]; other site 867900008172 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 867900008173 homodecamer interface [polypeptide binding]; other site 867900008174 GTP cyclohydrolase I; Provisional; Region: PLN03044 867900008175 active site 867900008176 putative catalytic site residues [active] 867900008177 zinc binding site [ion binding]; other site 867900008178 GTP-CH-I/GFRP interaction surface; other site 867900008179 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 867900008180 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 867900008181 Walker A/P-loop; other site 867900008182 ATP binding site [chemical binding]; other site 867900008183 Q-loop/lid; other site 867900008184 ABC transporter signature motif; other site 867900008185 Walker B; other site 867900008186 D-loop; other site 867900008187 H-loop/switch region; other site 867900008188 CAAX protease self-immunity; Region: Abi; pfam02517 867900008189 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 867900008190 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 867900008191 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 867900008192 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 867900008193 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_1; cd10801 867900008194 putative active site [active] 867900008195 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 867900008196 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 867900008197 GLPGLI family protein; Region: GLPGLI; TIGR01200 867900008198 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 867900008199 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 867900008200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 867900008201 Walker A motif; other site 867900008202 ATP binding site [chemical binding]; other site 867900008203 Walker B motif; other site 867900008204 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 867900008205 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 867900008206 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 867900008207 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 867900008208 active site 867900008209 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 867900008210 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 867900008211 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 867900008212 Ligand Binding Site [chemical binding]; other site 867900008213 TilS substrate C-terminal domain; Region: TilS_C; smart00977 867900008214 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 867900008215 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 867900008216 Predicted flavoprotein [General function prediction only]; Region: COG0431 867900008217 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 867900008218 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 867900008219 Acyltransferase family; Region: Acyl_transf_3; pfam01757 867900008220 CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704 867900008221 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 867900008222 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 867900008223 substrate binding site [chemical binding]; other site 867900008224 dimer interface [polypeptide binding]; other site 867900008225 ATP binding site [chemical binding]; other site 867900008226 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 867900008227 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 867900008228 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 867900008229 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 867900008230 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 867900008231 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 867900008232 dimerization interface [polypeptide binding]; other site 867900008233 putative DNA binding site [nucleotide binding]; other site 867900008234 putative Zn2+ binding site [ion binding]; other site 867900008235 AsnC family; Region: AsnC_trans_reg; pfam01037 867900008236 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 867900008237 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 867900008238 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 867900008239 catalytic residue [active] 867900008240 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 867900008241 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 867900008242 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 867900008243 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 867900008244 dimer interface [polypeptide binding]; other site 867900008245 decamer (pentamer of dimers) interface [polypeptide binding]; other site 867900008246 catalytic triad [active] 867900008247 peroxidatic and resolving cysteines [active] 867900008248 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 867900008249 catalytic residues [active] 867900008250 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 867900008251 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 867900008252 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 867900008253 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 867900008254 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 867900008255 tetramer interface [polypeptide binding]; other site 867900008256 heme binding pocket [chemical binding]; other site 867900008257 NADPH binding site [chemical binding]; other site 867900008258 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 867900008259 dimer interface [polypeptide binding]; other site 867900008260 catalytic triad [active] 867900008261 peroxidatic and resolving cysteines [active] 867900008262 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 867900008263 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 867900008264 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 867900008265 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 867900008266 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 867900008267 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 867900008268 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 867900008269 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 867900008270 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 867900008271 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 867900008272 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 867900008273 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 867900008274 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 867900008275 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 867900008276 dimerization interface [polypeptide binding]; other site 867900008277 active site 867900008278 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 867900008279 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 867900008280 inhibitor-cofactor binding pocket; inhibition site 867900008281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 867900008282 catalytic residue [active] 867900008283 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 867900008284 dimer interface [polypeptide binding]; other site 867900008285 FMN binding site [chemical binding]; other site 867900008286 hypothetical protein; Provisional; Region: PRK10621 867900008287 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 867900008288 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900008289 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 867900008290 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 867900008291 N-terminal plug; other site 867900008292 ligand-binding site [chemical binding]; other site 867900008293 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 867900008294 metal binding site 2 [ion binding]; metal-binding site 867900008295 putative DNA binding helix; other site 867900008296 metal binding site 1 [ion binding]; metal-binding site 867900008297 dimer interface [polypeptide binding]; other site 867900008298 structural Zn2+ binding site [ion binding]; other site 867900008299 RDD family; Region: RDD; pfam06271 867900008300 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 867900008301 Alginate lyase; Region: Alginate_lyase2; pfam08787 867900008302 McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117 867900008303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 867900008304 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 867900008305 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 867900008306 HsdM N-terminal domain; Region: HsdM_N; pfam12161 867900008307 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 867900008308 Methyltransferase domain; Region: Methyltransf_26; pfam13659 867900008309 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 867900008310 DEAD-like helicases superfamily; Region: DEXDc; smart00487 867900008311 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 867900008312 ATP binding site [chemical binding]; other site 867900008313 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 867900008314 putative Mg++ binding site [ion binding]; other site 867900008315 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 867900008316 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 867900008317 Ligand Binding Site [chemical binding]; other site 867900008318 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 867900008319 Ligand Binding Site [chemical binding]; other site 867900008320 Universal stress protein UspA and related nucleotide-binding proteins [Signal transduction mechanisms]; Region: UspA; COG0589 867900008321 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 867900008322 ArsC family; Region: ArsC; pfam03960 867900008323 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 867900008324 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 867900008325 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 867900008326 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 867900008327 catalytic residue [active] 867900008328 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 867900008329 Domain of unknown function (DUF1287); Region: DUF1287; pfam06940 867900008330 Domain of unknown function (DUF3806); Region: DUF3806; pfam12713 867900008331 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 867900008332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900008333 active site 867900008334 phosphorylation site [posttranslational modification] 867900008335 intermolecular recognition site; other site 867900008336 dimerization interface [polypeptide binding]; other site 867900008337 LytTr DNA-binding domain; Region: LytTR; smart00850 867900008338 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900008339 TPR motif; other site 867900008340 binding surface 867900008341 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900008342 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900008343 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900008344 binding surface 867900008345 TPR motif; other site 867900008346 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900008347 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900008348 Histidine kinase; Region: His_kinase; pfam06580 867900008349 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 867900008350 Mg2+ binding site [ion binding]; other site 867900008351 G-X-G motif; other site 867900008352 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 867900008353 AAA domain; Region: AAA_33; pfam13671 867900008354 AAA domain; Region: AAA_17; pfam13207 867900008355 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 867900008356 potential frameshift: common BLAST hit: gi|320117016|ref|YP_004187175.1| phospholipase D/transphosphatidylase 867900008357 PLD-like domain; Region: PLDc_2; pfam13091 867900008358 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 867900008359 putative active site [active] 867900008360 catalytic site [active] 867900008361 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 867900008362 PLD-like domain; Region: PLDc_2; pfam13091 867900008363 conserved repeat domain; Region: B_ant_repeat; TIGR01451 867900008364 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 867900008365 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 867900008366 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 867900008367 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 867900008368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 867900008369 putative substrate translocation pore; other site 867900008370 xylose isomerase; Provisional; Region: PRK05474 867900008371 xylose isomerase; Region: xylose_isom_A; TIGR02630 867900008372 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 867900008373 nucleotide binding site [chemical binding]; other site 867900008374 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 867900008375 DNA-binding site [nucleotide binding]; DNA binding site 867900008376 Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276 867900008377 putative dimerization interface [polypeptide binding]; other site 867900008378 putative ligand binding site [chemical binding]; other site 867900008379 Transcriptional regulators [Transcription]; Region: PurR; COG1609 867900008380 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 867900008381 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 867900008382 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 867900008383 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 867900008384 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 867900008385 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 867900008386 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 867900008387 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 867900008388 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 867900008389 TANFOR domain; Region: T_forsyth_147; TIGR02542 867900008390 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 867900008391 Interdomain contacts; other site 867900008392 Cytokine receptor motif; other site 867900008393 FOG: WD40-like repeat [Function unknown]; Region: COG1520 867900008394 Right handed beta helix region; Region: Beta_helix; pfam13229 867900008395 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 867900008396 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 867900008397 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 867900008398 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 867900008399 Ca binding site [ion binding]; other site 867900008400 ligand binding site I [chemical binding]; other site 867900008401 homodimer interface [polypeptide binding]; other site 867900008402 ligand binding site II [chemical binding]; other site 867900008403 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 867900008404 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 867900008405 Histidine kinase; Region: HisKA_2; pfam07568 867900008406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900008407 ATP binding site [chemical binding]; other site 867900008408 Mg2+ binding site [ion binding]; other site 867900008409 G-X-G motif; other site 867900008410 Response regulator receiver domain; Region: Response_reg; pfam00072 867900008411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900008412 active site 867900008413 phosphorylation site [posttranslational modification] 867900008414 intermolecular recognition site; other site 867900008415 dimerization interface [polypeptide binding]; other site 867900008416 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 867900008417 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 867900008418 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 867900008419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 867900008420 active site 867900008421 phosphorylation site [posttranslational modification] 867900008422 intermolecular recognition site; other site 867900008423 dimerization interface [polypeptide binding]; other site 867900008424 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 867900008425 DNA binding residues [nucleotide binding] 867900008426 dimerization interface [polypeptide binding]; other site 867900008427 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 867900008428 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 867900008429 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900008430 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 867900008431 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 867900008432 3D domain; Region: 3D; cl01439 867900008433 methionine sulfoxide reductase B; Provisional; Region: PRK00222 867900008434 SelR domain; Region: SelR; pfam01641 867900008435 methionine sulfoxide reductase A; Provisional; Region: PRK14054 867900008436 Predicted acetyltransferase [General function prediction only]; Region: COG2388 867900008437 Uncharacterized conserved protein [Function unknown]; Region: COG0397 867900008438 hypothetical protein; Validated; Region: PRK00029 867900008439 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 867900008440 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 867900008441 Domain of unknown function (DUF427); Region: DUF427; pfam04248 867900008442 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 867900008443 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 867900008444 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 867900008445 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 867900008446 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 867900008447 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 867900008448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 867900008449 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 867900008450 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 867900008451 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 867900008452 active site 867900008453 catalytic tetrad [active] 867900008454 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 867900008455 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 867900008456 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 867900008457 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 867900008458 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 867900008459 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 867900008460 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 867900008461 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 867900008462 Peptidase family M28; Region: Peptidase_M28; pfam04389 867900008463 metal binding site [ion binding]; metal-binding site 867900008464 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900008465 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900008466 binding surface 867900008467 TPR motif; other site 867900008468 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900008469 binding surface 867900008470 TPR motif; other site 867900008471 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900008472 TPR repeat; Region: TPR_11; pfam13414 867900008473 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 867900008474 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 867900008475 dimer interface [polypeptide binding]; other site 867900008476 phosphorylation site [posttranslational modification] 867900008477 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900008478 ATP binding site [chemical binding]; other site 867900008479 Mg2+ binding site [ion binding]; other site 867900008480 G-X-G motif; other site 867900008481 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900008482 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 867900008483 binding surface 867900008484 TPR motif; other site 867900008485 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 867900008486 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 867900008487 dimer interface [polypeptide binding]; other site 867900008488 phosphorylation site [posttranslational modification] 867900008489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900008490 ATP binding site [chemical binding]; other site 867900008491 Mg2+ binding site [ion binding]; other site 867900008492 G-X-G motif; other site 867900008493 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 867900008494 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 867900008495 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 867900008496 homodimer interface [polypeptide binding]; other site 867900008497 substrate-cofactor binding pocket; other site 867900008498 pyridoxal 5'-phosphate binding site [chemical binding]; other site 867900008499 catalytic residue [active] 867900008500 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349 867900008501 active site 867900008502 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 867900008503 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 867900008504 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 867900008505 heme-binding site [chemical binding]; other site 867900008506 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 867900008507 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 867900008508 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 867900008509 active site 867900008510 motif I; other site 867900008511 motif II; other site 867900008512 Maf-like protein; Region: Maf; pfam02545 867900008513 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 867900008514 active site 867900008515 dimer interface [polypeptide binding]; other site 867900008516 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 867900008517 Mechanosensitive ion channel; Region: MS_channel; pfam00924 867900008518 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 867900008519 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 867900008520 oligomer interface [polypeptide binding]; other site 867900008521 metal binding site [ion binding]; metal-binding site 867900008522 metal binding site [ion binding]; metal-binding site 867900008523 Cl binding site [ion binding]; other site 867900008524 aspartate ring; other site 867900008525 basic sphincter; other site 867900008526 putative hydrophobic gate; other site 867900008527 periplasmic entrance; other site 867900008528 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 867900008529 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 867900008530 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 867900008531 Na binding site [ion binding]; other site 867900008532 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 867900008533 Tetratricopeptide repeat; Region: TPR_12; pfam13424 867900008534 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 867900008535 ABC1 family; Region: ABC1; cl17513 867900008536 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 867900008537 active site 867900008538 ATP binding site [chemical binding]; other site 867900008539 substrate binding site [chemical binding]; other site 867900008540 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 867900008541 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 867900008542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 867900008543 NAD(P) binding site [chemical binding]; other site 867900008544 active site 867900008545 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 867900008546 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 867900008547 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 867900008548 active site 867900008549 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 867900008550 classical (c) SDRs; Region: SDR_c; cd05233 867900008551 NAD(P) binding site [chemical binding]; other site 867900008552 active site 867900008553 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 867900008554 catalytic residues [active] 867900008555 dimer interface [polypeptide binding]; other site 867900008556 TspO/MBR family; Region: TspO_MBR; pfam03073 867900008557 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 867900008558 putative hydrophobic ligand binding site [chemical binding]; other site 867900008559 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 867900008560 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 867900008561 hinge; other site 867900008562 active site 867900008563 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 867900008564 Protein of unknown function (DUF493); Region: DUF493; pfam04359 867900008565 Predicted ATPase [General function prediction only]; Region: COG3911 867900008566 AAA domain; Region: AAA_28; pfam13521 867900008567 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 867900008568 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 867900008569 ATP binding site [chemical binding]; other site 867900008570 putative Mg++ binding site [ion binding]; other site 867900008571 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 867900008572 nucleotide binding region [chemical binding]; other site 867900008573 ATP-binding site [chemical binding]; other site 867900008574 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 867900008575 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 867900008576 putative active site [active] 867900008577 substrate binding site [chemical binding]; other site 867900008578 putative cosubstrate binding site; other site 867900008579 catalytic site [active] 867900008580 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 867900008581 substrate binding site [chemical binding]; other site 867900008582 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 867900008583 IHF - DNA interface [nucleotide binding]; other site 867900008584 IHF dimer interface [polypeptide binding]; other site 867900008585 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 867900008586 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 867900008587 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 867900008588 homodimer interface [polypeptide binding]; other site 867900008589 substrate-cofactor binding pocket; other site 867900008590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 867900008591 catalytic residue [active] 867900008592 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 867900008593 hydrophobic ligand binding site; other site 867900008594 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 867900008595 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 867900008596 catalytic residues [active] 867900008597 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 867900008598 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 867900008599 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 867900008600 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 867900008601 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 867900008602 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 867900008603 non-specific DNA binding site [nucleotide binding]; other site 867900008604 salt bridge; other site 867900008605 sequence-specific DNA binding site [nucleotide binding]; other site 867900008606 Predicted transcriptional regulator [Transcription]; Region: COG2932 867900008607 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 867900008608 Catalytic site [active] 867900008609 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 867900008610 active site 867900008611 catalytic site [active] 867900008612 substrate binding site [chemical binding]; other site 867900008613 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 867900008614 GIY-YIG motif/motif A; other site 867900008615 active site 867900008616 catalytic site [active] 867900008617 metal binding site [ion binding]; metal-binding site 867900008618 hypothetical protein; Provisional; Region: PRK04233 867900008619 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 867900008620 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 867900008621 putative active site [active] 867900008622 heme pocket [chemical binding]; other site 867900008623 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 867900008624 putative active site [active] 867900008625 heme pocket [chemical binding]; other site 867900008626 PAS domain S-box; Region: sensory_box; TIGR00229 867900008627 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 867900008628 putative active site [active] 867900008629 heme pocket [chemical binding]; other site 867900008630 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 867900008631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900008632 ATP binding site [chemical binding]; other site 867900008633 Mg2+ binding site [ion binding]; other site 867900008634 G-X-G motif; other site 867900008635 Response regulator receiver domain; Region: Response_reg; pfam00072 867900008636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900008637 active site 867900008638 phosphorylation site [posttranslational modification] 867900008639 intermolecular recognition site; other site 867900008640 dimerization interface [polypeptide binding]; other site 867900008641 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 867900008642 ATP binding site [chemical binding]; other site 867900008643 active site 867900008644 substrate binding site [chemical binding]; other site 867900008645 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 867900008646 PhoH-like protein; Region: PhoH; pfam02562 867900008647 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 867900008648 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 867900008649 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 867900008650 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 867900008651 DNA polymerase III subunit beta; Validated; Region: PRK05643 867900008652 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 867900008653 putative DNA binding surface [nucleotide binding]; other site 867900008654 dimer interface [polypeptide binding]; other site 867900008655 beta-clamp/clamp loader binding surface; other site 867900008656 beta-clamp/translesion DNA polymerase binding surface; other site 867900008657 Tic20-like protein; Region: Tic20; pfam09685 867900008658 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 867900008659 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 867900008660 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 867900008661 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 867900008662 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 867900008663 trmE is a tRNA modification GTPase; Region: trmE; cd04164 867900008664 G1 box; other site 867900008665 GTP/Mg2+ binding site [chemical binding]; other site 867900008666 Switch I region; other site 867900008667 G2 box; other site 867900008668 Switch II region; other site 867900008669 G3 box; other site 867900008670 G4 box; other site 867900008671 G5 box; other site 867900008672 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 867900008673 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 867900008674 Helix-turn-helix domain; Region: HTH_17; cl17695 867900008675 Protein of unknown function (DUF3946); Region: DUF3946; pfam13102 867900008676 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 867900008677 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 867900008678 Int/Topo IB signature motif; other site 867900008679 Helix-turn-helix domain; Region: HTH_17; pfam12728 867900008680 Helix-turn-helix domain; Region: HTH_17; pfam12728 867900008681 VirE N-terminal domain; Region: VirE_N; pfam08800 867900008682 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 867900008683 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 867900008684 Helix-turn-helix domain; Region: HTH_31; pfam13560 867900008685 sequence-specific DNA binding site [nucleotide binding]; other site 867900008686 salt bridge; other site 867900008687 Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628 867900008688 5' RNA guide strand anchoring site; other site 867900008689 active site 867900008690 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 867900008691 Outer membrane efflux protein; Region: OEP; pfam02321 867900008692 Outer membrane efflux protein; Region: OEP; pfam02321 867900008693 HlyD family secretion protein; Region: HlyD_2; pfam12700 867900008694 HlyD family secretion protein; Region: HlyD_3; pfam13437 867900008695 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 867900008696 metal binding site 2 [ion binding]; metal-binding site 867900008697 putative DNA binding helix; other site 867900008698 metal binding site 1 [ion binding]; metal-binding site 867900008699 dimer interface [polypeptide binding]; other site 867900008700 structural Zn2+ binding site [ion binding]; other site 867900008701 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 867900008702 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 867900008703 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 867900008704 Soluble P-type ATPase [General function prediction only]; Region: COG4087 867900008705 Helix-turn-helix domain; Region: HTH_17; pfam12728 867900008706 Protein of unknown function (DUF3946); Region: DUF3946; pfam13102 867900008707 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 867900008708 HsdM N-terminal domain; Region: HsdM_N; pfam12161 867900008709 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 867900008710 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 867900008711 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 867900008712 Helix-turn-helix domain; Region: HTH_18; pfam12833 867900008713 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 867900008714 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 867900008715 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 867900008716 inhibitor site; inhibition site 867900008717 active site 867900008718 dimer interface [polypeptide binding]; other site 867900008719 catalytic residue [active] 867900008720 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 867900008721 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 867900008722 dimer interface [polypeptide binding]; other site 867900008723 NADP binding site [chemical binding]; other site 867900008724 catalytic residues [active] 867900008725 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 867900008726 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 867900008727 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 867900008728 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 867900008729 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 867900008730 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 867900008731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900008732 active site 867900008733 phosphorylation site [posttranslational modification] 867900008734 intermolecular recognition site; other site 867900008735 dimerization interface [polypeptide binding]; other site 867900008736 LytTr DNA-binding domain; Region: LytTR; smart00850 867900008737 Histidine kinase; Region: His_kinase; pfam06580 867900008738 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 867900008739 dimer interface [polypeptide binding]; other site 867900008740 FMN binding site [chemical binding]; other site 867900008741 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 867900008742 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 867900008743 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 867900008744 FAD binding pocket [chemical binding]; other site 867900008745 FAD binding motif [chemical binding]; other site 867900008746 phosphate binding motif [ion binding]; other site 867900008747 beta-alpha-beta structure motif; other site 867900008748 NAD binding pocket [chemical binding]; other site 867900008749 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 867900008750 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 867900008751 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 867900008752 FMN binding site [chemical binding]; other site 867900008753 active site 867900008754 catalytic residues [active] 867900008755 substrate binding site [chemical binding]; other site 867900008756 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 867900008757 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 867900008758 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 867900008759 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 867900008760 active site 867900008761 catalytic residues [active] 867900008762 polycystin cation channel protein; Region: PCC; TIGR00864 867900008763 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 867900008764 starch binding outer membrane protein SusD; Region: SusD; cd08977 867900008765 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900008766 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 867900008767 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 867900008768 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 867900008769 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 867900008770 dimerization interface [polypeptide binding]; other site 867900008771 DNA binding residues [nucleotide binding] 867900008772 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 867900008773 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 867900008774 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 867900008775 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 867900008776 ligand binding site [chemical binding]; other site 867900008777 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 867900008778 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 867900008779 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 867900008780 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 867900008781 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 867900008782 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 867900008783 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 867900008784 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 867900008785 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 867900008786 Cna protein B-type domain; Region: Cna_B_2; pfam13715 867900008787 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 867900008788 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 867900008789 N-terminal plug; other site 867900008790 ligand-binding site [chemical binding]; other site 867900008791 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 867900008792 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 867900008793 ligand binding site [chemical binding]; other site 867900008794 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 867900008795 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 867900008796 active site residue [active] 867900008797 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 867900008798 active site residue [active] 867900008799 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 867900008800 Predicted transporter component [General function prediction only]; Region: COG2391 867900008801 Predicted transporter component [General function prediction only]; Region: COG2391 867900008802 Sulphur transport; Region: Sulf_transp; pfam04143 867900008803 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 867900008804 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 867900008805 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 867900008806 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 867900008807 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 867900008808 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 867900008809 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 867900008810 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 867900008811 Uncharacterized conserved protein [Function unknown]; Region: COG4198 867900008812 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 867900008813 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 867900008814 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 867900008815 catalytic residue [active] 867900008816 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 867900008817 active site 867900008818 catalytic site [active] 867900008819 substrate binding site [chemical binding]; other site 867900008820 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 867900008821 GIY-YIG motif/motif A; other site 867900008822 active site 867900008823 catalytic site [active] 867900008824 putative DNA binding site [nucleotide binding]; other site 867900008825 metal binding site [ion binding]; metal-binding site 867900008826 Ion transport protein; Region: Ion_trans; pfam00520 867900008827 Ion channel; Region: Ion_trans_2; pfam07885 867900008828 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 867900008829 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 867900008830 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 867900008831 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 867900008832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 867900008833 active site 867900008834 phosphorylation site [posttranslational modification] 867900008835 intermolecular recognition site; other site 867900008836 dimerization interface [polypeptide binding]; other site 867900008837 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 867900008838 DNA binding site [nucleotide binding] 867900008839 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 867900008840 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 867900008841 dimer interface [polypeptide binding]; other site 867900008842 phosphorylation site [posttranslational modification] 867900008843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 867900008844 ATP binding site [chemical binding]; other site 867900008845 Mg2+ binding site [ion binding]; other site 867900008846 G-X-G motif; other site 867900008847 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 867900008848 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 867900008849 CoA-binding site [chemical binding]; other site 867900008850 ATP-binding [chemical binding]; other site 867900008851 YbbR-like protein; Region: YbbR; pfam07949 867900008852 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 867900008853 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 867900008854 active site 867900008855 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 867900008856 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 867900008857 NAD(P) binding site [chemical binding]; other site 867900008858 active site 867900008859 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 867900008860 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 867900008861 Walker A/P-loop; other site 867900008862 ATP binding site [chemical binding]; other site 867900008863 Q-loop/lid; other site 867900008864 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 867900008865 ABC transporter signature motif; other site 867900008866 Walker B; other site 867900008867 D-loop; other site 867900008868 H-loop/switch region; other site 867900008869 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 867900008870 Flavoprotein; Region: Flavoprotein; pfam02441 867900008871 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 867900008872 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 867900008873 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 867900008874 dihydrodipicolinate synthase; Region: dapA; TIGR00674 867900008875 dimer interface [polypeptide binding]; other site 867900008876 active site 867900008877 catalytic residue [active] 867900008878 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 867900008879 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 867900008880 nucleotide binding pocket [chemical binding]; other site 867900008881 K-X-D-G motif; other site 867900008882 catalytic site [active] 867900008883 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 867900008884 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 867900008885 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 867900008886 Dimer interface [polypeptide binding]; other site 867900008887 BRCT sequence motif; other site 867900008888 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 867900008889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 867900008890 S-adenosylmethionine binding site [chemical binding]; other site 867900008891 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 867900008892 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 867900008893 Coenzyme A binding pocket [chemical binding]; other site 867900008894 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 867900008895 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 867900008896 catalytic motif [active] 867900008897 Zn binding site [ion binding]; other site 867900008898 RibD C-terminal domain; Region: RibD_C; pfam01872 867900008899 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 867900008900 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 867900008901 motif II; other site 867900008902 EamA-like transporter family; Region: EamA; pfam00892 867900008903 Uncharacterized conserved protein [Function unknown]; Region: COG1739 867900008904 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 867900008905 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 867900008906 active site